Performance Engineering as an Expert System.

ERIC Educational Resources Information Center

Harmon, Paul

1984-01-01

Considers three powerful techniques--heuristics, context trees, and search via backward chaining--that a knowledge engineer might employ to develop an expert system to automate performance engineering, i.e., the branch of instructional technology that focuses on the problems of business and industry. (MBR)

Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals.

PubMed

Jullesson, David; David, Florian; Pfleger, Brian; Nielsen, Jens

2015-11-15

Industrial bio-processes for fine chemical production are increasingly relying on cell factories developed through metabolic engineering and synthetic biology. The use of high throughput techniques and automation for the design of cell factories, and especially platform strains, has played an important role in the transition from laboratory research to industrial production. Model organisms such as Saccharomyces cerevisiae and Escherichia coli remain widely used host strains for industrial production due to their robust and desirable traits. This review describes some of the bio-based fine chemicals that have reached the market, key metabolic engineering tools that have allowed this to happen and some of the companies that are currently utilizing these technologies for developing industrial production processes. Copyright © 2015 Elsevier Inc. All rights reserved.

Space Industry Commercialization: A Systems Engineering Evaluation of Alternatives

NASA Astrophysics Data System (ADS)

Dinally, Jihan

The Constellation Program cancellation reversed the government and commercial space industry's roles and relationships by dedicating the majority of the federal funding and opportunities to the commercial space industry and left the government space industry in search of an approach to collaborate with the dominant organization, the commercial space industry service providers. The space industry government agencies, Air Force Space Command (AFSPC) and National Aeronautics and Space Administration (NASA) had realized that to gain resources in the new commercially oriented economic environment, they had to work together and possess the capabilities aligned with the National Space Policy's documented goals. Multi-organizational collaboration in space industry programs is challenging, as NASA, AFSPC, and commercial providers, follow different [1] enterprise architecture guidance such as the NASA systems engineering Handbook, MIL-STD-499 and "A Guide to the systems engineering Body of Knowledge" by the International Council on systems engineering [2] [3]. A solution to streamline their enterprise architecture documentation and meet National Space Policy goals is the Multi-User Architecture Maturity Model Methodology (MAM3), which offers a tailored systems engineering technique the government agencies and private companies can implement for the program's maturity level. In order to demonstrate the MAM3, a CubeSat motivated study was conducted partnering a commercial provider with a government agency. A survey of the commercial space industry service providers' capabilities was performed to select the private companies for the study. Using the survey results, the commercial space industry service providers were ranked using the Analytic Hierarchy Process (AHP) [4]. The AHP is a structured technique for making complex decisions for representing and quantifying its weights, relating those weights to overall goals, and evaluating alternative solutions [5] - [8]. The weights applied to each of the alternatives [9] and criteria (i.e. goals) were based on the National Space Policy focused survey administered to United States owned commercial space industry service providers.

Biomedical Engineering Education in Perspective

ERIC Educational Resources Information Center

Gowen, Richard J.

1973-01-01

Discusses recent developments in the health care industry and their impact on the future of biomedical engineering education. Indicates that a more thorough understanding of the complex functions of the living organism can be acquired through the application of engineering techniques to problems of life sciences. (CC)

Ergonomics and design: its principles applied in the industry.

PubMed

Tavares, Ademario Santos; Silva, Francisco Nilson da

2012-01-01

Industrial Design encompasses both product development and optimization of production process. In this sense, Ergonomics plays a fundamental role, because its principles, methods and techniques can help operators to carry out their tasks most successfully. A case study carried out in an industry shows that the interaction among Design, Production Engineering and Materials Engineering departments may improve some aspects concerned security, comfort, efficiency and performance. In this process, Ergonomics had shown to be of essential importance to strategic decision making to the improvement of production section.

Metabolic Engineering VII Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kevin Korpics

The aims of this Metabolic Engineering conference are to provide a forum for academic and industrial researchers in the field; to bring together the different scientific disciplines that contribute to the design, analysis and optimization of metabolic pathways; and to explore the role of Metabolic Engineering in the areas of health and sustainability. Presentations, both written and oral, panel discussions, and workshops will focus on both applications and techniques used for pathway engineering. Various applications including bioenergy, industrial chemicals and materials, drug targets, health, agriculture, and nutrition will be discussed. Workshops focused on technology development for mathematical and experimental techniquesmore » important for metabolic engineering applications will be held for more in depth discussion. This 2008 meeting will celebrate our conference tradition of high quality and relevance to both industrial and academic participants, with topics ranging from the frontiers of fundamental science to the practical aspects of metabolic engineering.« less

Protein design in systems metabolic engineering for industrial strain development.

PubMed

Chen, Zhen; Zeng, An-Ping

2013-05-01

Accelerating the process of industrial bacterial host strain development, aimed at increasing productivity, generating new bio-products or utilizing alternative feedstocks, requires the integration of complementary approaches to manipulate cellular metabolism and regulatory networks. Systems metabolic engineering extends the concept of classical metabolic engineering to the systems level by incorporating the techniques used in systems biology and synthetic biology, and offers a framework for the development of the next generation of industrial strains. As one of the most useful tools of systems metabolic engineering, protein design allows us to design and optimize cellular metabolism at a molecular level. Here, we review the current strategies of protein design for engineering cellular synthetic pathways, metabolic control systems and signaling pathways, and highlight the challenges of this subfield within the context of systems metabolic engineering. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Recombinant organisms for production of industrial products

PubMed Central

Adrio, Jose-Luis

2010-01-01

A revolution in industrial microbiology was sparked by the discoveries of ther double-stranded structure of DNA and the development of recombinant DNA technology. Traditional industrial microbiology was merged with molecular biology to yield improved recombinant processes for the industrial production of primary and secondary metabolites, protein biopharmaceuticals and industrial enzymes. Novel genetic techniques such as metabolic engineering, combinatorial biosynthesis and molecular breeding techniques and their modifications are contributing greatly to the development of improved industrial processes. In addition, functional genomics, proteomics and metabolomics are being exploited for the discovery of novel valuable small molecules for medicine as well as enzymes for catalysis. The sequencing of industrial microbal genomes is being carried out which bodes well for future process improvement and discovery of new industrial products. PMID:21326937

The Transferability and Retraining of Defense Engineers.

ERIC Educational Resources Information Center

Rittenhouse, Carl H.

This study was undertaken to describe any special barriers to the transfer of engineers from defense to commercial work, and to evaluate retraining and reorientation techniques that might help ease the transfer. Interviews and questionnaires were used to obtain data from about 2,100 engineers and 100 managers in 14 industries. Characteristics,…

Teaching Applied Chemistry in a Pollution Control Context.

ERIC Educational Resources Information Center

Sell, Nancy J.

1982-01-01

Discusses rationale behind and content of a course (Industrial Pollution Control Techniques) combining knowledge from fields of industrial chemistry and chemical engineering and utilizing this knowledge in the context of understanding pollution problems and potential methods of pollution control. (Author/SK)

Recombinant organisms for production of industrial products.

PubMed

Adrio, Jose-Luis; Demain, Arnold L

2010-01-01

A revolution in industrial microbiology was sparked by the discoveries of ther double-stranded structure of DNA and the development of recombinant DNA technology. Traditional industrial microbiology was merged with molecular biology to yield improved recombinant processes for the industrial production of primary and secondary metabolites, protein biopharmaceuticals and industrial enzymes. Novel genetic techniques such as metabolic engineering, combinatorial biosynthesis and molecular breeding techniques and their modifications are contributing greatly to the development of improved industrial processes. In addition, functional genomics, proteomics and metabolomics are being exploited for the discovery of novel valuable small molecules for medicine as well as enzymes for catalysis. The sequencing of industrial microbal genomes is being carried out which bodes well for future process improvement and discovery of new industrial products. © 2010 Landes Bioscience

Computer program determines performance efficiency of remote measuring systems

NASA Technical Reports Server (NTRS)

Merewether, E. K.

1966-01-01

Computer programs control and evaluate instrumentation system performance for numerous rocket engine test facilities and prescribe calibration and maintenance techniques to maintain the systems within process specifications. Similar programs can be written for other test equipment in an industry such as the petrochemical industry.

Light-energy conversion in engineered microorganisms.

PubMed

Johnson, Ethan T; Schmidt-Dannert, Claudia

2008-12-01

Increasing interest in renewable resources by the energy and chemical industries has spurred new technologies both to capture solar energy and to develop biologically derived chemical feedstocks and fuels. Advances in molecular biology and metabolic engineering have provided new insights and techniques for increasing biomass and biohydrogen production, and recent efforts in synthetic biology have demonstrated that complex regulatory and metabolic networks can be designed and engineered in microorganisms. Here, we explore how light-driven processes may be incorporated into nonphotosynthetic microbes to boost metabolic capacity for the production of industrial and fine chemicals. Progress towards the introduction of light-driven proton pumping or anoxygenic photosynthesis into Escherichia coli to increase the efficiency of metabolically-engineered biosynthetic pathways is highlighted.

Metrics in method engineering

NASA Astrophysics Data System (ADS)

Brinkkemper, S.; Rossi, M.

1994-12-01

As customizable computer aided software engineering (CASE) tools, or CASE shells, have been introduced in academia and industry, there has been a growing interest into the systematic construction of methods and their support environments, i.e. method engineering. To aid the method developers and method selectors in their tasks, we propose two sets of metrics, which measure the complexity of diagrammatic specification techniques on the one hand, and of complete systems development methods on the other hand. Proposed metrics provide a relatively fast and simple way to analyze the technique (or method) properties, and when accompanied with other selection criteria, can be used for estimating the cost of learning the technique and the relative complexity of a technique compared to others. To demonstrate the applicability of the proposed metrics, we have applied them to 34 techniques and 15 methods.

Evolutionary engineering for industrial microbiology.

PubMed

Vanee, Niti; Fisher, Adam B; Fong, Stephen S

2012-01-01

Superficially, evolutionary engineering is a paradoxical field that balances competing interests. In natural settings, evolution iteratively selects and enriches subpopulations that are best adapted to a particular ecological niche using random processes such as genetic mutation. In engineering desired approaches utilize rational prospective design to address targeted problems. When considering details of evolutionary and engineering processes, more commonality can be found. Engineering relies on detailed knowledge of the problem parameters and design properties in order to predict design outcomes that would be an optimized solution. When detailed knowledge of a system is lacking, engineers often employ algorithmic search strategies to identify empirical solutions. Evolution epitomizes this iterative optimization by continuously diversifying design options from a parental design, and then selecting the progeny designs that represent satisfactory solutions. In this chapter, the technique of applying the natural principles of evolution to engineer microbes for industrial applications is discussed to highlight the challenges and principles of evolutionary engineering.

Applications of hybrid and digital computation methods in aerospace-related sciences and engineering. [problem solving methods at the University of Houston

NASA Technical Reports Server (NTRS)

Huang, C. J.; Motard, R. L.

1978-01-01

The computing equipment in the engineering systems simulation laboratory of the Houston University Cullen College of Engineering is described and its advantages are summarized. The application of computer techniques in aerospace-related research psychology and in chemical, civil, electrical, industrial, and mechanical engineering is described in abstracts of 84 individual projects and in reprints of published reports. Research supports programs in acoustics, energy technology, systems engineering, and environment management as well as aerospace engineering.

Protein engineering and its applications in food industry.

PubMed

Kapoor, Swati; Rafiq, Aasima; Sharma, Savita

2017-07-24

Protein engineering is a young discipline that has been branched out from the field of genetic engineering. Protein engineering is based on the available knowledge about the proteins structure/function(s), tools/instruments, software, bioinformatics database, available cloned gene, knowledge about available protein, vectors, recombinant strains and other materials that could lead to change in the protein backbone. Protein produced properly from genetic engineering process means a protein that is able to fold correctly and to do particular function(s) efficiently even after being subjected to engineering practices. Protein is modified through its gene or chemically. However, modification of protein through gene is easier. There is no specific limitation of Protein Engineering tools; any technique that can lead to change the protein constituent of amino acid and result in the modification of protein structure/function is in the frame of Protein Engineering. Meanwhile, there are some common tools used to reach a specific target. More active industrial and pharmaceutical based proteins have been invented by the field of Protein Engineering to introduce new function as well as to change its interaction with surrounding environment. A variety of protein engineering applications have been reported in the literature. These applications range from biocatalysis for food and industry to environmental, medical and nanobiotechnology applications. Successful combinations of various protein engineering methods had led to successful results in food industries and have created a scope to maintain the quality of finished product after processing.

Towards generating ECSS-compliant fault tree analysis results via ConcertoFLA

NASA Astrophysics Data System (ADS)

Gallina, B.; Haider, Z.; Carlsson, A.

2018-05-01

Attitude Control Systems (ACSs) maintain the orientation of the satellite in three-dimensional space. ACSs need to be engineered in compliance with ECSS standards and need to ensure a certain degree of dependability. Thus, dependability analysis is conducted at various levels and by using ECSS-compliant techniques. Fault Tree Analysis (FTA) is one of these techniques. FTA is being automated within various Model Driven Engineering (MDE)-based methodologies. The tool-supported CHESS-methodology is one of them. This methodology incorporates ConcertoFLA, a dependability analysis technique enabling failure behavior analysis and thus FTA-results generation. ConcertoFLA, however, similarly to other techniques, still belongs to the academic research niche. To promote this technique within the space industry, we apply it on an ACS and discuss about its multi-faceted potentialities in the context of ECSS-compliant engineering.

From protein engineering to immobilization: promising strategies for the upgrade of industrial enzymes.

PubMed

Singh, Raushan Kumar; Tiwari, Manish Kumar; Singh, Ranjitha; Lee, Jung-Kul

2013-01-10

Enzymes found in nature have been exploited in industry due to their inherent catalytic properties in complex chemical processes under mild experimental and environmental conditions. The desired industrial goal is often difficult to achieve using the native form of the enzyme. Recent developments in protein engineering have revolutionized the development of commercially available enzymes into better industrial catalysts. Protein engineering aims at modifying the sequence of a protein, and hence its structure, to create enzymes with improved functional properties such as stability, specific activity, inhibition by reaction products, and selectivity towards non-natural substrates. Soluble enzymes are often immobilized onto solid insoluble supports to be reused in continuous processes and to facilitate the economical recovery of the enzyme after the reaction without any significant loss to its biochemical properties. Immobilization confers considerable stability towards temperature variations and organic solvents. Multipoint and multisubunit covalent attachments of enzymes on appropriately functionalized supports via linkers provide rigidity to the immobilized enzyme structure, ultimately resulting in improved enzyme stability. Protein engineering and immobilization techniques are sequential and compatible approaches for the improvement of enzyme properties. The present review highlights and summarizes various studies that have aimed to improve the biochemical properties of industrially significant enzymes.

Looking ahead in systems engineering

NASA Technical Reports Server (NTRS)

Feigenbaum, Donald S.

1966-01-01

Five areas that are discussed in this paper are: (1) the technological characteristics of systems engineering; (2) the analytical techniques that are giving modern systems work its capability and power; (3) the management, economics, and effectiveness dimensions that now frame the modern systems field; (4) systems engineering's future impact upon automation, computerization and managerial decision-making in industry - and upon aerospace and weapons systems in government and the military; and (5) modern systems engineering's partnership with modern quality control and reliability.

Non-Genetic Engineering Approaches for Isolating and Generating Novel Yeasts for Industrial Applications

NASA Astrophysics Data System (ADS)

Chambers, P. J.; Bellon, J. R.; Schmidt, S. A.; Varela, C.; Pretorius, I. S.

Generating novel yeast strains for industrial applications should be quite straightforward; after all, research into the genetics, biochemistry and physiology of Baker's Yeast, Saccharomyces cerevisiae, has paved the way for many advances in the modern biological sciences. We probably know more about this humble eukaryote than any other, and it is the most tractable of organisms for manipulation using modern genetic engineering approaches. In many countries, however, there are restrictions on the use of genetically-modified organisms (GMOs), particularly in foods and beverages, and the level of consumer acceptance of GMOs is, at best, variable. Thus, many researchers working with industrial yeasts use genetic engineering techniques primarily as research tools, and strain development continues to rely on non-GM technologies. This chapter explores the non-GM tools and strategies available to such researchers.

Blasting Rocks and Blasting Cars Applied Engineering

ScienceCinema

LBNL

2017-12-09

June 30, 2004 Berkeley Lab lecture: Deb Hopkins works with industries like automobile, mining and paper to improve their evaluation and measuring techniques. For several years, she has coordinated ... June 30, 2004 Berkeley Lab lecture: Deb Hopkins works with industries like automobile, mining and paper to improve their evaluation and measuring techniques. For several years, she has coordinated a program at Berkeley Lab funded under the Partnership for a New Generation of Vehicles, a collaboration between the federal government and the U.S. Council for Automotive Research. Nondestructive evaluation techniques to test a car's structural integrity are being developed for auto assembly lines.

Industrial graphene metrology.

PubMed

Kyle, Jennifer Reiber; Ozkan, Cengiz S; Ozkan, Mihrimah

2012-07-07

Graphene is an allotrope of carbon whose structure is based on one-atom-thick planar sheets of carbon atoms that are densely packed in a honeycomb crystal lattice. Its unique electrical and optical properties raised worldwide interest towards the design and fabrication of future electronic and optical devices with unmatched performance. At the moment, extensive efforts are underway to evaluate the reliability and performance of a number of such devices. With the recent advances in synthesizing large-area graphene sheets, engineers have begun investigating viable methodologies for conducting graphene metrology and quality control at industrial scales to understand a variety of reliability issues including defects, patternability, electrical, and physical properties. This review summarizes the current state of industrial graphene metrology and provides an overview of graphene metrology techniques. In addition, a recently developed large-area graphene metrology technique based on fluorescence quenching is introduced. For each metrology technique, the industrial metrics it measures are identified--layer thickness, edge structure, defects, Fermi level, and thermal conductivity--and a detailed description is provided as to how the measurements are performed. Additionally, the potential advantages of each technique for industrial use are identified, including throughput, scalability, sensitivity to substrate/environment, and on their demonstrated ability to achieve quantified results. The recently developed fluorescence-quenching metrology technique is shown to meet all the necessary criteria for industrial applications, rendering it the first industry-ready graphene metrology technique.

Practical Techniques for Modeling Gas Turbine Engine Performance

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Lavelle, Thomas M.; Litt, Jonathan S.

2016-01-01

The cost and risk associated with the design and operation of gas turbine engine systems has led to an increasing dependence on mathematical models. In this paper, the fundamentals of engine simulation will be reviewed, an example performance analysis will be performed, and relationships useful for engine control system development will be highlighted. The focus will be on thermodynamic modeling utilizing techniques common in industry, such as: the Brayton cycle, component performance maps, map scaling, and design point criteria generation. In general, these topics will be viewed from the standpoint of an example turbojet engine model; however, demonstrated concepts may be adapted to other gas turbine systems, such as gas generators, marine engines, or high bypass aircraft engines. The purpose of this paper is to provide an example of gas turbine model generation and system performance analysis for educational uses, such as curriculum creation or student reference.

Genome-wide analytical approaches for reverse metabolic engineering of industrially relevant phenotypes in yeast

PubMed Central

Oud, Bart; Maris, Antonius J A; Daran, Jean-Marc; Pronk, Jack T

2012-01-01

Successful reverse engineering of mutants that have been obtained by nontargeted strain improvement has long presented a major challenge in yeast biotechnology. This paper reviews the use of genome-wide approaches for analysis of Saccharomyces cerevisiae strains originating from evolutionary engineering or random mutagenesis. On the basis of an evaluation of the strengths and weaknesses of different methods, we conclude that for the initial identification of relevant genetic changes, whole genome sequencing is superior to other analytical techniques, such as transcriptome, metabolome, proteome, or array-based genome analysis. Key advantages of this technique over gene expression analysis include the independency of genome sequences on experimental context and the possibility to directly and precisely reproduce the identified changes in naive strains. The predictive value of genome-wide analysis of strains with industrially relevant characteristics can be further improved by classical genetics or simultaneous analysis of strains derived from parallel, independent strain improvement lineages. PMID:22152095

Genome-wide analytical approaches for reverse metabolic engineering of industrially relevant phenotypes in yeast.

PubMed

Oud, Bart; van Maris, Antonius J A; Daran, Jean-Marc; Pronk, Jack T

2012-03-01

Successful reverse engineering of mutants that have been obtained by nontargeted strain improvement has long presented a major challenge in yeast biotechnology. This paper reviews the use of genome-wide approaches for analysis of Saccharomyces cerevisiae strains originating from evolutionary engineering or random mutagenesis. On the basis of an evaluation of the strengths and weaknesses of different methods, we conclude that for the initial identification of relevant genetic changes, whole genome sequencing is superior to other analytical techniques, such as transcriptome, metabolome, proteome, or array-based genome analysis. Key advantages of this technique over gene expression analysis include the independency of genome sequences on experimental context and the possibility to directly and precisely reproduce the identified changes in naive strains. The predictive value of genome-wide analysis of strains with industrially relevant characteristics can be further improved by classical genetics or simultaneous analysis of strains derived from parallel, independent strain improvement lineages. © 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

Breaking Ground: Improving Undergraduate Engineering Projects through Flipped Teaching of Literature Search Techniques

ERIC Educational Resources Information Center

Maddison, Tasha; Beneteau, Donna; Sokoloski, Brandy

2014-01-01

This case study describes the use of flipped teaching for information literacy instruction in a new course, "Drill, Blast, and Excavate GeoE 498," within the mining option for geological engineering (GeoE) students. These students will enter the mining industry with less discipline-specific knowledge than a student that graduated with a…

Aircraft Piston Engine Exhaust Emission Symposium

NASA Technical Reports Server (NTRS)

1976-01-01

A 2-day symposium on the reduction of exhaust emissions from aircraft piston engines was held on September 14 and 15, 1976, at the Lewis Research Center in Cleveland, Ohio. Papers were presented by both government organizations and the general aviation industry on the status of government contracts, emission measurement problems, data reduction procedures, flight testing, and emission reduction techniques.

The Bologna Process Implementation and its Consequent Changes in the Teaching/Learning Model—the Industrial Management and Engineering Degree Case

NASA Astrophysics Data System (ADS)

Luísa Soares, Ana; Costa, Elga; Ferreira, Luís Pinto

2009-11-01

The present paper aims to present a Project included in a diversified programme and consequent implementation of a new Teaching/Learning model adapted to the Industrial Management and Engineering Degree (IMED) of the Management and Industrial Studies School (O'Porto Polytechnic Institute). Owning particular and specific characteristics, this model is based on the graduates' professional profile as well as on the work market dynamics, placing the student in the centre of the Learning Process, in opposition to the `teacher centred' method (as conceived by the Bologna Treat). Diverse in the approach, the model includes differentiating factors when compared to the project based traditional model. Through the development and conception of practical Interdisciplinary Projects, centring knowledges and techniques from the different Industrial Management and Engineering areas, we seek a new way of implementing the `Project Led Education' (PLE) bases, according to the Active Learning paradigm. This teaching/learning model aims to contribute to the Industrial Management and Engineering graduates' formation focused on a high level of performance and professional rectitude, to induce students' enthusiasm and motivation for acquiring scientific and technical knowledge, as well as to satisfy the diverse interest groups' expectations and promote the regional development.

Molecular genetic improvements of cyanobacteria to enhance the industrial potential of the microbe: A review.

PubMed

Johnson, Tylor J; Gibbons, Jaimie L; Gu, Liping; Zhou, Ruanbao; Gibbons, William R

2016-11-01

The rapid increase in worldwide population coupled with the increasing demand for fossil fuels has led to an increased urgency to develop sustainable sources of energy and chemicals from renewable resources. Using microorganisms to produce high-value chemicals and next-generation biofuels is one sustainable option and is the focus of much current research. Cyanobacteria are ideal platform organisms for chemical and biofuel production because they can be genetically engineered to produce a broad range of products directly from CO 2 , H 2 O, and sunlight, and require minimal nutrient inputs. The purpose of this review is to provide an overview on advances that have been or could be made to improve strains of cyanobacteria for industrial purposes. First, the benefits of using cyanobacteria as a platform for chemical and biofuel production are discussed. Next, an overview of cyanobacterial strain improvements by genetic engineering is provided. Finally, mutagenesis techniques to improve the industrial potential of cyanobacteria are described. Along with providing an overview on various areas of research that are currently being investigated to improve the industrial potential of cyanobacteria, this review aims to elucidate potential targets for future research involving cyanobacteria as an industrial microorganism. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:1357-1371, 2016. © 2016 American Institute of Chemical Engineers.

From Protein Engineering to Immobilization: Promising Strategies for the Upgrade of Industrial Enzymes

PubMed Central

Singh, Raushan Kumar; Tiwari, Manish Kumar; Singh, Ranjitha; Lee, Jung-Kul

2013-01-01

Enzymes found in nature have been exploited in industry due to their inherent catalytic properties in complex chemical processes under mild experimental and environmental conditions. The desired industrial goal is often difficult to achieve using the native form of the enzyme. Recent developments in protein engineering have revolutionized the development of commercially available enzymes into better industrial catalysts. Protein engineering aims at modifying the sequence of a protein, and hence its structure, to create enzymes with improved functional properties such as stability, specific activity, inhibition by reaction products, and selectivity towards non-natural substrates. Soluble enzymes are often immobilized onto solid insoluble supports to be reused in continuous processes and to facilitate the economical recovery of the enzyme after the reaction without any significant loss to its biochemical properties. Immobilization confers considerable stability towards temperature variations and organic solvents. Multipoint and multisubunit covalent attachments of enzymes on appropriately functionalized supports via linkers provide rigidity to the immobilized enzyme structure, ultimately resulting in improved enzyme stability. Protein engineering and immobilization techniques are sequential and compatible approaches for the improvement of enzyme properties. The present review highlights and summarizes various studies that have aimed to improve the biochemical properties of industrially significant enzymes. PMID:23306150

13 CFR 120.331 - What devices or techniques are eligible for a loan?

Code of Federal Regulations, 2012 CFR

2012-01-01

... heating or production of energy from industrial waste; (f) Hydroelectric power equipment; (g) Wind energy conversion equipment; and (h) Engineering, architectural, consulting, or other professional services...

13 CFR 120.331 - What devices or techniques are eligible for a loan?

Code of Federal Regulations, 2011 CFR

2011-01-01

... heating or production of energy from industrial waste; (f) Hydroelectric power equipment; (g) Wind energy conversion equipment; and (h) Engineering, architectural, consulting, or other professional services...

13 CFR 120.331 - What devices or techniques are eligible for a loan?

Code of Federal Regulations, 2013 CFR

2013-01-01

... heating or production of energy from industrial waste; (f) Hydroelectric power equipment; (g) Wind energy conversion equipment; and (h) Engineering, architectural, consulting, or other professional services...

13 CFR 120.331 - What devices or techniques are eligible for a loan?

Code of Federal Regulations, 2010 CFR

2010-01-01

... heating or production of energy from industrial waste; (f) Hydroelectric power equipment; (g) Wind energy conversion equipment; and (h) Engineering, architectural, consulting, or other professional services...

13 CFR 120.331 - What devices or techniques are eligible for a loan?

Code of Federal Regulations, 2014 CFR

2014-01-01

... heating or production of energy from industrial waste; (f) Hydroelectric power equipment; (g) Wind energy conversion equipment; and (h) Engineering, architectural, consulting, or other professional services...

Computational aero-acoustics for fan duct propagation and radiation. Current status and application to turbofan liner optimisation

NASA Astrophysics Data System (ADS)

Astley, R. J.; Sugimoto, R.; Mustafi, P.

2011-08-01

Novel techniques are presented to reduce noise from turbofan aircraft engines by optimising the acoustic treatment in engine ducts. The application of Computational Aero-Acoustics (CAA) to predict acoustic propagation and absorption in turbofan ducts is reviewed and a critical assessment of performance indicates that validated and accurate techniques are now available for realistic engine predictions. A procedure for integrating CAA methods with state of the art optimisation techniques is proposed in the remainder of the article. This is achieved by embedding advanced computational methods for noise prediction within automated and semi-automated optimisation schemes. Two different strategies are described and applied to realistic nacelle geometries and fan sources to demonstrate the feasibility of this approach for industry scale problems.

Calibration Experiments for a Computer Vision Oyster Volume Estimation System

ERIC Educational Resources Information Center

Chang, G. Andy; Kerns, G. Jay; Lee, D. J.; Stanek, Gary L.

2009-01-01

Calibration is a technique that is commonly used in science and engineering research that requires calibrating measurement tools for obtaining more accurate measurements. It is an important technique in various industries. In many situations, calibration is an application of linear regression, and is a good topic to be included when explaining and…

Blasting Rocks and Blasting Cars Applied Engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

LBNL

2008-07-02

June 30, 2004 Berkeley Lab lecture: Deb Hopkins works with industries like automobile, mining and paper to improve their evaluation and measuring techniques. For several years, she has coordinated ... June 30, 2004 Berkeley Lab lecture: Deb Hopkins works with industries like automobile, mining and paper to improve their evaluation and measuring techniques. For several years, she has coordinated a program at Berkeley Lab funded under the Partnership for a New Generation of Vehicles, a collaboration between the federal government and the U.S. Council for Automotive Research. Nondestructive evaluation techniques to test a car's structural integrity are being developed formore » auto assembly lines.« less

Development and Experimental Study of Education Through the Synergetic Training for the Engineering Enhanced Medicine “ESTEEM” in Tohoku University

NASA Astrophysics Data System (ADS)

Yamano, Masahiro; Matsuki, Noriaki; Numayama, Keiko; Takeda, Motohiro; Hayasaka, Tomoaki; Ishikawa, Takuji; Yamaguchi, Takami

We developed new bio-medical engineering curriculum for industrial engineers, and we confirmed that the engineer's needs and the educative effects by holding a trail program. This study in Tohoku University was supported by the Ministry of Economy, Trade and Industry (METI) . We named the curriculum as “ESTEEM” which is acronym of project title “Education through the Synergetic Training for the Engineering Enhanced Medicine” . In Tohoku University, the “REDEEM” curriculum which is an entry level course of bio-medical engineering for engineers has been already held. The positioning of “ESTEEM” program is an advanced course to enhance knowledge and experience in clinical point of view. The program is consisted of the problem based learning (PBL) style lectures, practical training, and observation learning in hospital. It is a unique opportunity to have instruction by doctors, from diagnosis to surgical operation, from traditional technique to front-line medical equipment. In this paper, we report and discuss on the progress of the new bio-medical engineering curriculum.

Final-Year Projects as a Major Element in the IE Curriculum

ERIC Educational Resources Information Center

Vitner, G.; Rozenes, S.

2009-01-01

This paper presents a multi-perspective view of the final-year project of an industrial engineering and management (IEM) department. The final year project is a major element of a 4-year curriculum within any engineering discipline. Such a project gives the student an opportunity to use and implement methods, techniques and tools that he or she…

Green biocides, a promising technology: current and future applications to industry and industrial processes.

PubMed

Ashraf, Muhammad Aqeel; Ullah, Saleem; Ahmad, Irshad; Qureshi, Ahmad Kaleem; Balkhair, Khaled S; Abdur Rehman, Muhammad

2014-02-01

The study of biofilms has skyrocketed in recent years due to increased awareness of the pervasiveness and impact of biofilms. It costs the USA literally billions of dollars every year in energy losses, equipment damage, product contamination and medical infections. But biofilms also offer huge potential for cleaning up hazardous waste sites, filtering municipal and industrial water and wastewater, and forming biobarriers to protect soil and groundwater from contamination. The complexity of biofilm activity and behavior requires research contributions from many disciplines such as biochemistry, engineering, mathematics and microbiology. The aim of this review is to provide a comprehensive analysis of emerging novel antimicrobial techniques, including those using myriad organic and inorganic products as well as genetic engineering techniques, the use of coordination complex molecules, composite materials and antimicrobial peptides and the use of lasers as such or their modified use in combination treatments. This review also addresses advanced and recent modifications, including methodological changes, and biocide efficacy enhancing strategies. This review will provide future planners of biofilm control technologies with a broad understanding and perspective on the use of biocides in the field of green developments for a sustainable future. © 2013 Society of Chemical Industry.

Quality and management of wastewater in sugar industry

NASA Astrophysics Data System (ADS)

Poddar, Pradeep Kumar; Sahu, Omprakash

2017-03-01

Wastewater from sugar industries is one that has complex characteristics and is considered a challenge for environmental engineers in terms of treatment as well as utilization. Before treatment and recycling, determination of physicochemical parameter is an important mechanism. Many different types of techniques are introduced and modified for the purpose, but depend upon the water quality parameters. The main aim of this study is to determine the physicochemical characteristics of sugar industry waste water by the standard method and minimize the fresh water consumption in sugar industry by water pinch methodology.

Estimating Environmental Compliance Costs for Industry (1981)

EPA Pesticide Factsheets

The paper discusses the pros and cons of existing approaches to compliance cost estimation such as ex post survey estimation and ex ante estimation techniques (input cost accounting methods, engineering process models and, econometric models).

Artistic and Industrial Institutions in Russian Education Structure in First Quarter of XXth Century

NASA Astrophysics Data System (ADS)

Chernyh, D. G.

2017-11-01

The article tells about the formation of Russian design education in the XXth century. It focuses on the peculiar features and causes of its insufficient effectiveness in the historical context. It studies the dynamics of changes in the priorities related to the artistic and industrial education in Russia and the connection of these processes with socio-political transformations. The article identifies the role of constructivist artists in the formation and approbation of advanced design-engineering techniques. It emphasizes the interdisciplinary essence of the profession of a designer as a special kind of design activities, its organizing, consolidating and progressive origin in the sphere of industrial production and carrying out interdisciplinary studies. It discloses the essence of a new “engineer-artist” profession. It briefly describes the influence of the fundamental principle of design - projectivity, on engineering and design disciplines when the interaction of an artist, an engineer and an architect is achieved on the basis of design, arrangement and inventive art as well as production organization where science and technology form the basis for creative work.

3D Printing and Biofabrication for Load Bearing Tissue Engineering.

PubMed

Jeong, Claire G; Atala, Anthony

2015-01-01

Cell-based direct biofabrication and 3D bioprinting is becoming a dominant technological platform and is suggested as a new paradigm for twenty-first century tissue engineering. These techniques may be our next step in surpassing the hurdles and limitations of conventional scaffold-based tissue engineering, and may offer the industrial potential of tissue engineered products especially for load bearing tissues. Here we present a topically focused review regarding the fundamental concepts, state of the art, and perspectives of this new technology and field of biofabrication and 3D bioprinting, specifically focused on tissue engineering of load bearing tissues such as bone, cartilage, osteochondral and dental tissue engineering.

Designing primary health care teams for developing countries.

PubMed Central

Reisman, A; Duran, L

1983-01-01

A time-honored industrial engineering technique, job evaluation, which was developed to set rates for manual labor, was used in the design of new teams for delivering primary health care in Latin America. The technique was used both in writing job descriptions for new allied health personnel and in designing the curriculums needed to train the personnel. PMID:6856744

Bioinspiration: applying mechanical design to experimental biology.

PubMed

Flammang, Brooke E; Porter, Marianne E

2011-07-01

The production of bioinspired and biomimetic constructs has fostered much collaboration between biologists and engineers, although the extent of biological accuracy employed in the designs produced has not always been a priority. Even the exact definitions of "bioinspired" and "biomimetic" differ among biologists, engineers, and industrial designers, leading to confusion regarding the level of integration and replication of biological principles and physiology. By any name, biologically-inspired mechanical constructs have become an increasingly important research tool in experimental biology, offering the opportunity to focus research by creating model organisms that can be easily manipulated to fill a desired parameter space of structural and functional repertoires. Innovative researchers with both biological and engineering backgrounds have found ways to use bioinspired models to explore the biomechanics of organisms from all kingdoms to answer a variety of different questions. Bringing together these biologists and engineers will hopefully result in an open discourse of techniques and fruitful collaborations for experimental and industrial endeavors.

Readings in Systems Engineering

NASA Technical Reports Server (NTRS)

Hoban, Francis T. (Editor); Lawbaugh, William M. (Editor)

1993-01-01

This present collection was inspired by seven papers prepared by the NASA Alumni League, illustrating the members' systems engineering experience. These papers make up the heart of this collection. We have supplemented them with papers describing industry processes and other governmental practices to illustrate the diversity of systems engineering as it is formulated and practiced. This is one discipline that clearly benefits from cross-fertilization and infusion of new ideas. There is also a wide variety of tools and techniques described herein, some standard and some unique.

Teaching Separations: Why, What, When, and How?

ERIC Educational Resources Information Center

Wankat, Phillip C.

2001-01-01

Describes how and when to teach separation science to chemical engineering students. Separation science is important for industrial businesses involving the manufacture of adsorption systems, distillation columns, extractors, and other separation equipment and techniques. (Contains 13 references.) (YDS)

Assessment of the Autonomous Learning Competence in Engineering Degree Courses at the Universitat Politècnica De Catalunya

ERIC Educational Resources Information Center

Olmedo-Torre, Noelia; Farrerons Vidal, Oscar

2017-01-01

We present a strategy for the acquisition and assessment of autonomous learning conducted as part of the Graphic Expression in Engineering (GE) degree course during the first quarter at the Escola Universitària d'Enginyeria Tècnica Industrial de Barcelona (EUETIB). The strategy employed is the puzzle technique in the classroom and multiple-choice…

Industrial Relevance of Chromosomal Copy Number Variation in Saccharomyces Yeasts.

PubMed

Gorter de Vries, Arthur R; Pronk, Jack T; Daran, Jean-Marc G

2017-06-01

Chromosomal copy number variation (CCNV) plays a key role in evolution and health of eukaryotes. The unicellular yeast Saccharomyces cerevisiae is an important model for studying the generation, physiological impact, and evolutionary significance of CCNV. Fundamental studies of this yeast have contributed to an extensive set of methods for analyzing and introducing CCNV. Moreover, these studies provided insight into the balance between negative and positive impacts of CCNV in evolutionary contexts. A growing body of evidence indicates that CCNV not only frequently occurs in industrial strains of Saccharomyces yeasts but also is a key contributor to the diversity of industrially relevant traits. This notion is further supported by the frequent involvement of CCNV in industrially relevant traits acquired during evolutionary engineering. This review describes recent developments in genome sequencing and genome editing techniques and discusses how these offer opportunities to unravel contributions of CCNV in industrial Saccharomyce s strains as well as to rationally engineer yeast chromosomal copy numbers and karyotypes. Copyright © 2017 Gorter de Vries et al.

Industrial Relevance of Chromosomal Copy Number Variation in Saccharomyces Yeasts

PubMed Central

Gorter de Vries, Arthur R.; Pronk, Jack T.

2017-01-01

ABSTRACT Chromosomal copy number variation (CCNV) plays a key role in evolution and health of eukaryotes. The unicellular yeast Saccharomyces cerevisiae is an important model for studying the generation, physiological impact, and evolutionary significance of CCNV. Fundamental studies of this yeast have contributed to an extensive set of methods for analyzing and introducing CCNV. Moreover, these studies provided insight into the balance between negative and positive impacts of CCNV in evolutionary contexts. A growing body of evidence indicates that CCNV not only frequently occurs in industrial strains of Saccharomyces yeasts but also is a key contributor to the diversity of industrially relevant traits. This notion is further supported by the frequent involvement of CCNV in industrially relevant traits acquired during evolutionary engineering. This review describes recent developments in genome sequencing and genome editing techniques and discusses how these offer opportunities to unravel contributions of CCNV in industrial Saccharomyces strains as well as to rationally engineer yeast chromosomal copy numbers and karyotypes. PMID:28341679

Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery.

PubMed

Baritugo, Kei-Anne; Kim, Hee Taek; David, Yokimiko; Choi, Jong-Il; Hong, Soon Ho; Jeong, Ki Jun; Choi, Jong Hyun; Joo, Jeong Chan; Park, Si Jae

2018-05-01

Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for L-glutamate and L-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2-C6 platform chemicals using recombinant C. glutamicum.

White biotechnology: State of the art strategies for the development of biocatalysts for biorefining.

PubMed

Heux, S; Meynial-Salles, I; O'Donohue, M J; Dumon, C

2015-12-01

White biotechnology is a term that is now often used to describe the implementation of biotechnology in the industrial sphere. Biocatalysts (enzymes and microorganisms) are the key tools of white biotechnology, which is considered to be one of the key technological drivers for the growing bioeconomy. Biocatalysts are already present in sectors such as the chemical and agro-food industries, and are used to manufacture products as diverse as antibiotics, paper pulp, bread or advanced polymers. This review proposes an original and global overview of highly complementary fields of biotechnology at both enzyme and microorganism level. A certain number of state of the art approaches that are now being used to improve the industrial fitness of biocatalysts particularly focused on the biorefinery sector are presented. The first part deals with the technologies that underpin the development of industrial biocatalysts, notably the discovery of new enzymes and enzyme improvement using directed evolution techniques. The second part describes the toolbox available by the cell engineer to shape the metabolism of microorganisms. And finally the last part focuses on the 'omic' technologies that are vital for understanding and guide microbial engineering toward more efficient microbial biocatalysts. Altogether, these techniques and strategies will undoubtedly help to achieve the challenging task of developing consolidated bioprocessing (i.e. CBP) readily available for industrial purpose. Copyright © 2015 Elsevier Inc. All rights reserved.

Improving safety of aircraft engines: a consortium approach

NASA Astrophysics Data System (ADS)

Brasche, Lisa J. H.

1996-11-01

With over seven million departures per year, air transportation has become not a luxury, but a standard mode of transportation for the United States. A critical aspect of modern air transport is the jet engine, a complex engineered component that has enabled the rapid travel to which we have all become accustomed. One of the enabling technologies for safe air travel is nondestructive evaluation, or NDE, which includes various inspection techniques used to assess the health or integrity of a structure, component, or material. The Engine Titanium Consortium (ETC) was established in 1993 to respond to recommendations made by the Federal Aviation Administration (FAA) Titanium Rotating Components Review Team (TRCRT) for improvements in inspection of engine titanium. Several recent accomplishments of the ETC are detailed in this paper. The objective of the Engine Titanium Consortium is to provide the FAAand the manufacturers with reliable and costeffective new methods and/or improvements in mature methods for detecting cracks, inclusions, and imperfections in titanium. The consortium consists of a team of researchers from academia and industry-namely, Iowa State University, Allied Signal Propulsion Engines, General Electric Aircraft Engines, and Pratt & Whitney Engines-who work together to develop program priorities, organize a program plan, conduct the research, and implement the solutions. The true advantage of the consortium approach is that it brings together the research talents of academia and the engineering talents of industry to tackle a technology-base problem. In bringing industrial competitors together, the consortium ensures that the research results, which have safety implications and result from FAA funds, are shared and become part of the public domain.

Engine System Loads Analysis Compared to Hot-Fire Data

NASA Technical Reports Server (NTRS)

Frady, Gregory P.; Jennings, John M.; Mims, Katherine; Brunty, Joseph; Christensen, Eric R.; McConnaughey, Paul R. (Technical Monitor)

2002-01-01

Early implementation of structural dynamics finite element analyses for calculation of design loads is considered common design practice for high volume manufacturing industries such as automotive and aeronautical industries. However with the rarity of rocket engine development programs starts, these tools are relatively new to the design of rocket engines. In the NASA MC-1 engine program, the focus was to reduce the cost-to-weight ratio. The techniques for structural dynamics analysis practices, were tailored in this program to meet both production and structural design goals. Perturbation of rocket engine design parameters resulted in a number of MC-1 load cycles necessary to characterize the impact due to mass and stiffness changes. Evolution of loads and load extraction methodologies, parametric considerations and a discussion of load path sensitivities are important during the design and integration of a new engine system. During the final stages of development, it is important to verify the results of an engine system model to determine the validity of the results. During the final stages of the MC-1 program, hot-fire test results were obtained and compared to the structural design loads calculated by the engine system model. These comparisons are presented in this paper.

Application of reverse engineering in the medical industry.

NASA Astrophysics Data System (ADS)

Kaleev, A. A.; Kashapov, L. N.; Kashapov, N. F.; Kashapov, R. N.

2017-09-01

The purpose of this research is to develop on the basis of existing analogs new design of ophthalmologic microsurgical tweezers by using reverse engineering techniques. Virtual model was obtained by using a three-dimensional scanning system Solutionix Rexcan 450 MP. Geomagic Studio program was used to remove defects and inaccuracies of the obtained parametric model. A prototype of the finished model was made on the installation of laser stereolithography Projet 6000. Total time of the creation was 16 hours from the reverse engineering procedure to 3D-printing of the prototype.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moyer, Bruce A.

The North American industry has employed major solvent-extraction processes to support a wide range of separations including but not limited to chemical, metallurgical, nuclear, biochemical, pharmaceutical, and petroleum applications. The knowledge enabling these separations has been obtained through fundamental studies in academe, government and industry. The International Solvent Extraction Conferences have been and continue to be a major gathering of scientists, engineers, operators, and vendors from around the world, who present new findings since the last meeting, exchange ideas, make business contacts, and conduct collegial discussions. The ISEC 2008 program emphasizes fundamentals to industrial applications of solvent extraction, particularly howmore » this broad spectrum of activities is interconnected and has led to the implementation of novel processes. The oral and poster sessions have been organized into seven topics: Fundamentals; Novel Reagents, Materials and Techniques; Nuclear Fuel Reprocessing; Hydrometallurgy and Metals Extraction; Analytical and Preparative Applications; Biotechnology, Pharmaceuticals, Life-Science Products, and Organic Products; and Process Chemistry and Engineering. Over 350 abstracts were received, resulting in more than 260 manuscripts published in these proceedings. Five outstanding plenary presentations have been identified, with five parallel sessions for oral presentations and posters. In recognition of the major role solvent extraction (SX) plays in the hydrometallurgical and nuclear industries, these proceedings begin with sections focusing on hydrometallurgy, process chemistry, and engineering. More fundamental topics follow, including sections on novel reagents, materials, and techniques, featuring novel applications in analytical and biotechnology areas. Despite the diversity of topics and ideas represented, however, the primary focus of the ISEC community continues to be metals extraction. Four papers from these proceedings have been entered already in INIS in the form of individual reports. Among the remaining papers, 60 have been selected from the following sessions: Plenary Lectures, Hydrometallurgy and Metals Extraction, Nuclear Fuel Reprocessing, Analytical and Preparative Applications, Fundamentals, and Novel Reagents, Materials, and Techniques.« less

Identification and assessment of professional competencies for implementation of nanotechnology in engineering education

NASA Astrophysics Data System (ADS)

Jean, Ming-Der; Jiang, Ji-Bin; Chien, Jia-Yi

2017-11-01

The purpose of this study was to construct the indicators of professional competencies of the nanotechnology-based sputtering system industry based on industry requirements and analyse the core competencies of the industry for promoting the human resource of physical vapour deposition technology. The document analysis, expert interview, and Delphi technique surveys were considered and the survey items with 32 items divided into 7 domains were selected according to consensus opinions of 10 experts by the Delphi survey technique. Through three questionnaire surveys' analysis, the professional competence scales for the K-S tests showed a good internal consistency. The findings of this study provide guidelines for professional competence for nanotechnology-based sputtering technology by applying surface heat-treatment industry. These guidelines can also reveal the practical competency requirements of nanotechnology-based sputtering technology to deal with any subsequent challenges, future developments, and invisible services for students in a technology institute programme.

Automated packing systems: review of industrial implementations

NASA Astrophysics Data System (ADS)

Whelan, Paul F.; Batchelor, Bruce G.

1993-08-01

A rich theoretical background to the problems that occur in the automation of material handling can be found in operations research, production engineering, systems engineering and automation, more specifically machine vision, literature. This work has contributed towards the design of intelligent handling systems. This paper will review the application of these automated material handling and packing techniques to industrial problems. The discussion will also highlight the systems integration issues involved in these applications. An outline of one such industrial application, the automated placement of shape templates on to leather hides, is also discussed. The purpose of this system is to arrange shape templates on a leather hide in an efficient manner, so as to minimize the leather waste, before they are automatically cut from the hide. These pieces are used in the furniture and car manufacturing industries for the upholstery of high quality leather chairs and car seats. Currently this type of operation is semi-automated. The paper will outline the problems involved in the full automation of such a procedure.

C style guide

NASA Technical Reports Server (NTRS)

Doland, Jerry; Valett, Jon

1994-01-01

This document discusses recommended practices and style for programmers using the C language in the Flight Dynamics Division environment. Guidelines are based on generally recommended software engineering techniques, industry resources, and local convention. The Guide offers preferred solutions to common C programming issues and illustrates through examples of C Code.

Laser-induced incandescence: Particulate diagnostics for combustion, atmospheric, and industrial applications

DOE PAGES

Michelsen, H. A.; Schulz, C.; Smallwood, G. J.; ...

2015-09-09

The understanding of soot formation in combustion processes and the optimization of practical combustion systems require in situ measurement techniques that can provide important characteristics, such as particle concentrations and sizes, under a variety of conditions. Of equal importance are techniques suitable for characterizing soot particles produced from incomplete combustion and emitted into the environment. Also, the production of engineered nanoparticles, such as carbon blacks, may benefit from techniques that allow for online monitoring of these processes.

Improvement of Biocatalysts for Industrial and Environmental Purposes by Saturation Mutagenesis

PubMed Central

Valetti, Francesca; Gilardi, Gianfranco

2013-01-01

Laboratory evolution techniques are becoming increasingly widespread among protein engineers for the development of novel and designed biocatalysts. The palette of different approaches ranges from complete randomized strategies to rational and structure-guided mutagenesis, with a wide variety of costs, impacts, drawbacks and relevance to biotechnology. A technique that convincingly compromises the extremes of fully randomized vs. rational mutagenesis, with a high benefit/cost ratio, is saturation mutagenesis. Here we will present and discuss this approach in its many facets, also tackling the issue of randomization, statistical evaluation of library completeness and throughput efficiency of screening methods. Successful recent applications covering different classes of enzymes will be presented referring to the literature and to research lines pursued in our group. The focus is put on saturation mutagenesis as a tool for designing novel biocatalysts specifically relevant to production of fine chemicals for improving bulk enzymes for industry and engineering technical enzymes involved in treatment of waste, detoxification and production of clean energy from renewable sources. PMID:24970191

Preliminary Component Integration Using Rapid Prototyping Techniques

NASA Technical Reports Server (NTRS)

Cooper, Ken; Salvail, Pat; Gordon, Gail (Technical Monitor)

2001-01-01

Rapid prototyping is a very important tool that should be used by both design and manufacturing disciplines during the development of elements for the aerospace industry. It helps prevent lack of adequate communication between design and manufacturing engineers (which could lead to costly errors) through mutual consideration of functional models generated from drawings. Rapid prototyping techniques are used to test hardware for design and material compatibility at Marshall Space Flight Center.

Modular magazine for suitable handling of microparts in industry

NASA Astrophysics Data System (ADS)

Grimme, Ralf; Schmutz, Wolfgang; Schlenker, Dirk; Schuenemann, Matthias; Stock, Achim; Schaefer, Wolfgang

1998-01-01

Microassembly and microadjustment techniques are key technologies in the industrial production of hybrid microelectromechanical systems. One focal point in current microproduction research and engineering is the design and development of high-precision microassembly and microadjustment equipment capable of operating within the framework of flexible automated industrial production. As well as these developments, suitable microassembly tools for industrial use also need to be equipped with interfaces for the supply and delivery of microcomponents. The microassembly process necessitates the supply of microparts in a geometrically defined manner. In order to reduce processing steps and production costs, there is a demand for magazines capable of providing free accessibility to the fixed microcomponents. Commonly used at present are feeding techniques, which originate from the field of semiconductor production. However none of these techniques fully meets the requirements of industrial microassembly technology. A novel modular magazine set, developed and tested in a joint project, is presented here. The magazines are able to hold microcomponents during cleaning, inspection and assembly without nay additional handling steps. The modularity of their design allows for maximum technical flexibility. The modular magazine fits into currently practiced SEMI standards. The design and concept of the magazine enables industrial manufacturers to promote a cost-efficient and flexible precision assembly of microelectromechanical systems.

Product Mix Selection Using AN Evolutionary Technique

NASA Astrophysics Data System (ADS)

Tsoulos, Ioannis G.; Vasant, Pandian

2009-08-01

This paper proposes an evolutionary technique for the solution of a real—life industrial problem and particular for the product mix selection problem. The evolutionary technique is a combination of a genetic algorithm that preserves the feasibility of the trial solutions with penalties and some local optimization method. The goal of this paper has been achieved in finding the best near optimal solution for the profit fitness function respect to vagueness factor and level of satisfaction. The findings of the profit values will be very useful for the decision makers in the industrial engineering sector for the implementation purpose. It's possible to improve the solutions obtained in this study by employing other meta-heuristic methods such as simulated annealing, tabu Search, ant colony optimization, particle swarm optimization and artificial immune systems.

Software engineering project management - A state-of-the-art report

NASA Technical Reports Server (NTRS)

Thayer, R. H.; Lehman, J. H.

1977-01-01

The management of software engineering projects in the aerospace industry was investigated. The survey assessed such features as contract type, specification preparation techniques, software documentation required by customers, planning and cost-estimating, quality control, the use of advanced program practices, software tools and test procedures, the education levels of project managers, programmers and analysts, work assignment, automatic software monitoring capabilities, design and coding reviews, production times, success rates, and organizational structure of the projects.

Drafting--Basic, Drafting--Intermediate: 9255.01.

ERIC Educational Resources Information Center

Dade County Public Schools, Miami, FL.

The course has no prerequisites, offers instruction in basic drafting room techniques and procedures, and also covers job opportunities and industrial methods in engineering. The student is introduced to and asked to perform fundamental drafting problems with working drawings, using multiview and auxiliary views and sections. The course also…

Application of polarization in high speed, high contrast inspection

NASA Astrophysics Data System (ADS)

Novak, Matthew J.

2017-08-01

Industrial optical inspection often requires high speed and high throughput of materials. Engineers use a variety of techniques to handle these inspection needs. Some examples include line scan cameras, high speed multi-spectral and laser-based systems. High-volume manufacturing presents different challenges for inspection engineers. For example, manufacturers produce some components in quantities of millions per month, per week or even per day. Quality control of so many parts requires creativity to achieve the measurement needs. At times, traditional vision systems lack the contrast to provide the data required. In this paper, we show how dynamic polarization imaging captures high contrast images. These images are useful for engineers to perform inspection tasks in some cases where optical contrast is low. We will cover basic theory of polarization. We show how to exploit polarization as a contrast enhancement technique. We also show results of modeling for a polarization inspection application. Specifically, we explore polarization techniques for inspection of adhesives on glass.

New Turbo Compound Systems in Automotive Industry for Internal Combustion Engine to Recover Energy

NASA Astrophysics Data System (ADS)

Chiriac, R.; Chiru, A.; Condrea, O.

2017-10-01

The large amount of heat is scattered in the internal combustion engine through exhaust gas, coolant, convective and radiant heat transfer. Of all these residual heat sources, exhaust gases have the potential to recover using various modern heat recovery techniques. Waste heat recovery from an engine could directly reduce fuel consumption, increase available electrical power and improve overall system efficiency and if it would be used a turbochargers that can also produce energy. This solution is called turbo aggregation and has other ways to develop it in other areas of research like the electrical field. [1-3

Biofuel metabolic engineering with biosensors.

PubMed

Morgan, Stacy-Anne; Nadler, Dana C; Yokoo, Rayka; Savage, David F

2016-12-01

Metabolic engineering offers the potential to renewably produce important classes of chemicals, particularly biofuels, at an industrial scale. DNA synthesis and editing techniques can generate large pathway libraries, yet identifying the best variants is slow and cumbersome. Traditionally, analytical methods like chromatography and mass spectrometry have been used to evaluate pathway variants, but such techniques cannot be performed with high throughput. Biosensors - genetically encoded components that actuate a cellular output in response to a change in metabolite concentration - are therefore a promising tool for rapid and high-throughput evaluation of candidate pathway variants. Applying biosensors can also dynamically tune pathways in response to metabolic changes, improving balance and productivity. Here, we describe the major classes of biosensors and briefly highlight recent progress in applying them to biofuel-related metabolic pathway engineering. Copyright © 2016 Elsevier Ltd. All rights reserved.

Materials Coating Techniques

DTIC Science & Technology

1980-03-01

applications from decorative to utilitarian over significant segments of the engineering, chemical, nuclear , microelectronics, and related Industries. PVD...Thermal-control coating. Boron 2430 Cermet component, nuclear shielding and controlrod material; Carbide wear- and temperature-resistant. Calcium...Zirconium Oxide (Hafnia-Pree � Thermal-barrier coatings for nuclear applications. Lime Stabi!Aed) Zirconium 2563 Resistant to high-temperature

Comparison of multiple gene assembly methods for metabolic engineering

Treesearch

Chenfeng Lu; Karen Mansoorabadi; Thomas Jeffries

2007-01-01

A universal, rapid DNA assembly method for efficient multigene plasmid construction is important for biological research and for optimizing gene expression in industrial microbes. Three different approaches to achieve this goal were evaluated. These included creating long complementary extensions using a uracil-DNA glycosylase technique, overlap extension polymerase...

Interdisciplinary Curriculum Development in Hospital Methods Improvement. Final Report.

ERIC Educational Resources Information Center

Watt, John R.

The major purpose of this project was to develop a "package" curriculum of Hospital Methods Improvement techniques for college students in health related majors. The elementary Industrial Engineering methods for simplifying work and saving labor were applied to the hospital environment and its complex of problems. The report's…

Blasting Rocks and Blasting Cars: Applied Engineering (LBNL Summer Lecture Series)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopkins, Deborah

2004-06-30

Summer Lecture Series 2004: Deb Hopkins works with industries like automobile, mining and paper to improve their evaluation and measuring techniques. For several years, she has coordinated a program at Berkeley Lab funded under the Partnership for a New Generation of Vehicles, a collaboration between the federal government and the U.S. Council for Automotive Research. Nondestructive evaluation techniques to test a car's structural integrity are being developed for auto assembly lines.

Blasting Rocks and Blasting Cars: Applied Engineering (LBNL Summer Lecture Series)

ScienceCinema

Hopkins, Deborah [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Engineering Division

2017-12-09

Summer Lecture Series 2004: Deb Hopkins works with industries like automobile, mining and paper to improve their evaluation and measuring techniques. For several years, she has coordinated a program at Berkeley Lab funded under the Partnership for a New Generation of Vehicles, a collaboration between the federal government and the U.S. Council for Automotive Research. Nondestructive evaluation techniques to test a car's structural integrity are being developed for auto assembly lines.

Preparing the NDE engineers of the future: Education, training, and diversity

NASA Astrophysics Data System (ADS)

Holland, Stephen D.

2017-02-01

As quantitative NDE has matured and entered the mainstream, it has created an industry need for engineers who can select, evaluate, and qualify NDE techniques to satisfy quantitative engineering requirements. NDE as a field is cross-disciplinary with major NDE techniques relying on a broad spectrum of physics disciplines including fluid mechanics, electromagnetics, mechanical waves, and high energy physics. An NDE engineer needs broad and deep understanding of the measurement physics across modalities, a general engineering background, and familiarity with shop-floor practices and tools. While there are a wide range of certification and training programs worldwide for NDE technicians, there are few programs aimed at engineers. At the same time, substantial demographic shifts are underway with many experienced NDE engineers and technicians nearing retirement, and with new generations coming from much more diverse backgrounds. There is a need for more and better education opportunities for NDE engineers. Both teaching and learning NDE engineering are inherently challenging because of the breadth and depth of knowledge required. At the same time, sustaining the field in a more diverse era will require broadening participation of previously underrepresented groups. The QNDE 2016 conference in Atlanta, GA included a session on NDE education, training, and diversity. This paper summarizes the outcomes and discussion from this session.

Lost Opportunity: The High Quality, Reduced Military Force of the 1990’s: Is there a Role for the Nation’s Disadvantaged Youth?

DTIC Science & Technology

1990-12-01

others based on detailed, quantitative "manpower engineering " techniques (White and Hosek, in Scowcroft, 1982, p. 51). 3. The Military Force and...complex technology does not involve a corresponding increase in more highly trained personnel. Trends in industry suggest that job titles are often...theories of motivation, two of which are relevant to this analysis and will be briefly described below. Expectancy theory, with roots in industrial

Building Efficiency Technologies by Tomorrow’s Engineers and Researchers (BETTER) Capstone. Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yee, Shannon

BETTER Capstone supported 29 student project teams consisting of 155 students over two years in developing transformative building energy efficiency technologies through a capstone design experience. Capstone is the culmination of an undergraduate student’s engineering education. Interdisciplinary teams of students spent a semester designing and prototyping a technological solution for a variety building energy efficiency problems. During this experience students utilized the full design process, including the manufacturing and testing of a prototype solution, as well as publically demonstrating the solution at the Capstone Design Expo. As part of this project, students explored modern manufacturing techniques and gained hands-on experiencemore » with these techniques to produce their prototype technologies. This research added to the understanding of the challenges within building technology education and engagement with industry. One goal of the project was to help break the chicken-and-egg problem with getting students to engage more deeply with the building technology industry. It was learned however that this industry is less interested in trying innovative new concept but rather interested in hiring graduates for existing conventional building efforts. While none of the projects yielded commercial success, much individual student growth and learning was accomplished, which is a long-term benefit to the public at large.« less

Orion FSW V and V and Kedalion Engineering Lab Insight

NASA Technical Reports Server (NTRS)

Mangieri, Mark L.

2010-01-01

NASA, along with its prime Orion contractor and its subcontractor s are adapting an avionics system paradigm borrowed from the manned commercial aircraft industry for use in manned space flight systems. Integrated Modular Avionics (IMA) techniques have been proven as a robust avionics solution for manned commercial aircraft (B737/777/787, MD 10/90). This presentation will outline current approaches to adapt IMA, along with its heritage FSW V&V paradigms, into NASA's manned space flight program for Orion. NASA's Kedalion engineering analysis lab is on the forefront of validating many of these contemporary IMA based techniques. Kedalion has already validated many of the proposed Orion FSW V&V paradigms using Orion's precursory Flight Test Article (FTA) Pad Abort 1 (PA-1) program. The Kedalion lab will evolve its architectures, tools, and techniques in parallel with the evolving Orion program.

Bridging worlds/charting new courses

NASA Astrophysics Data System (ADS)

This report describes the work being done within Sandia's renewable energy program. This work touches on four major disciplines. (1) Photovoltaics. The goal of this project is to develop costeffective, reliable energy system technologies for energy supplies worldwide produced by U.S. industry. It encompasses cell research and development, collector development, technology evaluation, systems engineering, domestic and international applications, and design assistance. (2) Solar Thermal. This project endeavors to develop and increase acceptance of solar thermal electric and industrial technologies as cost-competitive candidates for power generation and to promote their commercialization. Its' major activities are with dish/Stirling systems, the Solar Two power tower, design assistance to industry and users, technology development and research activities. (3) Wind. The wind project impacts domestic and international markets with commercially feasible systems for utility-scale and other applications of wind energy. The project conducts applied research in aerodynamics, structural dynamics, fatigue, materials and controls, and engineering systems, and develops cooperative work with industry. (4) Geothermal. This project is developing technology to increase proven geothermal reserves and is assisting industry in expanding geothermal power on-line. Development work is in stemhole drilling, drilling techniques, instrumentation for geothermal wells, acoustic telemetry, and drilling exploratory wells.

TRIZ: A Bridge Between Applied and Industrial Physics

NASA Astrophysics Data System (ADS)

Savransky, Semyon

1997-03-01

TRIZ provides a methodology for creative engineering design. TRIZ was founded by Genrich S. Altshuller in Russia, whose with co-workers analyses about 1,500,000 worldwide patents. The major TRIZ principles are [1,2]: 1. All engineering systems have uniform evolution. Many other systems (economic, educational, etc.) have the same evolution trends. 2. Any inventive problem represents a conflict between new requirements and old system. TRIZ comprises various systematically techniques to find an quasi-ideal answer to the inventive problem through solve the conflict based on the knowledge of a system evolution. Usually the hidden root of technical problem is physical contradictions that is possible to resolve using the lists of effects. TRIZ experts use a knowledge base of applied physics to provide solutions of industrial problems . Many companies around the world cite a phenomenal increase in the producti-vity and quality of solutions to tough engineering problems through the use of TRIZ. [1]. G. S. Altshuller, B.L. Zlotin, A.V. Zusman and V.I. Filatov, The new ideas search: From intuition to technology. (in Russian) Kishinev, 1989, 381p. [2]. S.D. Savransky, and C. Stephan, TRIZ: Methodology of Inventive Problem Solving. The Indust-rial Physicist (December 1996).

Rapid directed evolution of stabilized proteins with cellular high-throughput encapsulation solubilization and screening (CHESS).

PubMed

Yong, K J; Scott, D J

2015-03-01

Directed evolution is a powerful method for engineering proteins towards user-defined goals and has been used to generate novel proteins for industrial processes, biological research and drug discovery. Typical directed evolution techniques include cellular display, phage display, ribosome display and water-in-oil compartmentalization, all of which physically link individual members of diverse gene libraries to their translated proteins. This allows the screening or selection for a desired protein function and subsequent isolation of the encoding gene from diverse populations. For biotechnological and industrial applications there is a need to engineer proteins that are functional under conditions that are not compatible with these techniques, such as high temperatures and harsh detergents. Cellular High-throughput Encapsulation Solubilization and Screening (CHESS), is a directed evolution method originally developed to engineer detergent-stable G proteins-coupled receptors (GPCRs) for structural biology. With CHESS, library-transformed bacterial cells are encapsulated in detergent-resistant polymers to form capsules, which serve to contain mutant genes and their encoded proteins upon detergent mediated solubilization of cell membranes. Populations of capsules can be screened like single cells to enable rapid isolation of genes encoding detergent-stable protein mutants. To demonstrate the general applicability of CHESS to other proteins, we have characterized the stability and permeability of CHESS microcapsules and employed CHESS to generate thermostable, sodium dodecyl sulfate (SDS) resistant green fluorescent protein (GFP) mutants, the first soluble proteins to be engineered using CHESS. © 2014 Wiley Periodicals, Inc.

Innovative Techniques Simplify Vibration Analysis

NASA Technical Reports Server (NTRS)

2010-01-01

In the early years of development, Marshall Space Flight Center engineers encountered challenges related to components in the space shuttle main engine. To assess the problems, they evaluated the effects of vibration and oscillation. To enhance the method of vibration signal analysis, Marshall awarded Small Business Innovation Research (SBIR) contracts to AI Signal Research, Inc. (ASRI), in Huntsville, Alabama. ASRI developed a software package called PC-SIGNAL that NASA now employs on a daily basis, and in 2009, the PKP-Module won Marshall s Software of the Year award. The technology is also used in many industries: aircraft and helicopter, rocket engine manufacturing, transportation, and nuclear power."

Comparison of Marketing Techniques to Enroll Females at a Major Aeronautical University

ERIC Educational Resources Information Center

Cross, David Scott

2012-01-01

Traditionally, industries belonging to the science, technology, engineering, and mathematics (STEM) fields are dominated by males. Recruitment and enrollment of females for STEM fields have become an issue among universities specializing in fields such as aviation and aeronautics. The research problem for this study was that marketing departments…

The National Shipbuilding Research Program. Application of Industrial Engineering Techniques to Reduce Workers’ Compensation and Environmental Costs - Deliverable F

DTIC Science & Technology

1999-10-01

body size, pre-existing medical conditions, medication and sedentary lifestyle . Team members learned from professional speakers and other training...for the retired military employee who may lead a more " sedentary lifestyle ". Smoking and overeating are also negative factors that increase the

Mechanical properties of wood fiber composites under the influence of temperature and humidity

Treesearch

Yibin Xue; David Veazie; Cindy Glinsey; Meagan Wright; Roger M. Rowell

2003-01-01

Woodfiber-thermoplastic composites (WPC) have received considerable attentions from the forest product industry for civil engineering applications due to its superior properties over wood and plastics alone. Particularly WPCs can be easily fabricated using traditional plastic processing techniques. The major limitation in the applications of WPCs is the poor...

What Is the Function of a Figurine? Can the Repertory Grid Technique Tell?

ERIC Educational Resources Information Center

Persson, Helena Isakssson

2016-01-01

Teaching design and product development at upper secondary school level in Sweden is a matter of interdisciplinary considerations. Education in product development, at this level, prepares students for further studies and career in engineering or industrial design. Knowledge of artefacts is an important element in the education. In coherence with…

Development of a Situated Spectrum Analyzer Learning Platform for Enhancing Student Technical Skills

ERIC Educational Resources Information Center

Chuang, Chien-Pen; Jou, Min; Lin, Yen-Ting; Lu, Cheng-Tien

2015-01-01

Electronic engineering industries require technical specialists to operate precision electronic instruments. However, limitations in course designs and equipment availability mean that only a few students are able to use the equipment in practical lessons within a limited timeframe. Also, instruction of techniques and skills are still mostly…

Error-proofing test system of industrial components based on image processing

NASA Astrophysics Data System (ADS)

Huang, Ying; Huang, Tao

2018-05-01

Due to the improvement of modern industrial level and accuracy, conventional manual test fails to satisfy the test standards of enterprises, so digital image processing technique should be utilized to gather and analyze the information on the surface of industrial components, so as to achieve the purpose of test. To test the installation parts of automotive engine, this paper employs camera to capture the images of the components. After these images are preprocessed including denoising, the image processing algorithm relying on flood fill algorithm is used to test the installation of the components. The results prove that this system has very high test accuracy.

Directed evolution: tailoring biocatalysts for industrial applications.

PubMed

Kumar, Ashwani; Singh, Suren

2013-12-01

Current challenges and promises of white biotechnology encourage protein engineers to use a directed evolution approach to generate novel and useful biocatalysts for various sets of applications. Different methods of enzyme engineering have been used in the past in an attempt to produce enzymes with improved functions and properties. Recent advancement in the field of random mutagenesis, screening, selection and computational design increased the versatility and the rapid development of enzymes under strong selection pressure with directed evolution experiments. Techniques of directed evolution improve enzymes fitness without understanding them in great detail and clearly demonstrate its future role in adapting enzymes for use in industry. Despite significant advances to date regarding biocatalyst improvement, there still remains a need to improve mutagenesis strategies and development of easy screening and selection tools without significant human intervention. This review covers fundamental and major development of directed evolution techniques, and highlights the advances in mutagenesis, screening and selection methods with examples of enzymes developed by using these approaches. Several commonly used methods for creating molecular diversity with their advantages and disadvantages including some recently used strategies are also discussed.

Theory and practice: How do we teach our students about light?

NASA Astrophysics Data System (ADS)

Creath, Katherine

2007-08-01

As optical scientists and engineers we have an educational paradigm that stresses passing knowledge from teacher to student. We are also taught to use inductive reasoning to solve problems. Yet many of the fundamental questions in optics such as the topic of this conference "What are photons?" require that we use retroductive reasoning to deduce the possible and probable cause of the observations and measurements we make. We can agree that we don't have all the answers for many fundamental questions in optics. The retroductive reasoning process requires a different way of thinking from our traditional classroom setting. Most of us learned to do this through working in a research lab or industry. With the amount of information and new discoveries to consider, it makes it difficult to cover everything in the classroom. This paper looks at transformational learning techniques and how they have been applied in science and engineering. These techniques show promise to prepare our students to learn how to learn and develop skills they can directly apply to research and industry.

Nalco Fuel Tech

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michalak, S.

1995-12-31

The Nalco Fuel Tech with its seat at Naperville (near Chicago), Illinois, is an engineering company working in the field of technology and equipment for environmental protection. A major portion of NALCO products constitute chemical materials and additives used in environmental protection technologies (waste-water treatment plants, water treatment, fuel modifiers, etc.). Basing in part on the experience, laboratories and RD potential of the mother company, the Nalco Fuel Tech Company developed and implemented in the power industry a series of technologies aimed at the reduction of environment-polluting products of fuel combustion. The engineering solution of Nalco Fuel Tech belong tomore » a new generation of environmental protection techniques developed in the USA. They consist in actions focused on the sources of pollutants, i.e., in upgrading the combustion chambers of power engineering plants, e.g., boilers or communal and/or industrial waste combustion units. The Nalco Fuel Tech development and research group cooperates with leading US investigation and research institutes.« less

The Engineering Potential of Rhodosporidium toruloides as a Workhorse for Biotechnological Applications.

PubMed

Park, Young-Kyoung; Nicaud, Jean-Marc; Ledesma-Amaro, Rodrigo

2018-03-01

Moving our society towards a bioeconomy requires efficient and sustainable microbial production of chemicals and fuels. Rhodotorula (Rhodosporidium) toruloides is a yeast that naturally synthesizes substantial amounts of specialty chemicals and has been recently engineered to (i) enhance its natural production of lipids and carotenoids, and (ii) produce novel industrially relevant compounds. The use of R. toruloides by companies and research groups has exponentially increased in recent years as a result of recent improvements in genetic engineering techniques and the availability of multiomics information on its genome and metabolism. This review focuses on recent engineering approaches in R. toruloides for bioproduction and explores its potential as a biotechnological chassis. Copyright © 2017 Elsevier Ltd. All rights reserved.

Job Prospects for Industrial Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1988-01-01

Discusses 1987 statistics from the College Placement Council regarding new job offers to graduating industrial engineers. Identifies trends in hiring in the field. Describes several issues that will face industrial engineers. States that the industrial engineers most likely to win jobs are those with good basic mathematics and communications…

Suitability of online 3D visualization technique in oil palm plantation management

NASA Astrophysics Data System (ADS)

Mat, Ruzinoor Che; Nordin, Norani; Zulkifli, Abdul Nasir; Yusof, Shahrul Azmi Mohd

2016-08-01

Oil palm industry has been the backbone for the growth of Malaysia economy. The exports of this commodity increasing almost every year. Therefore, there are many studies focusing on how to help this industry increased its productivity. In order to increase the productivity, the management of oil palm plantation need to be improved and strengthen. One of the solution in helping the oil palm manager is by implementing online 3D visualization technique for oil palm plantation using game engine technology. The potential of this application is that it can helps in fertilizer and irrigation management. For this reason, the aim of this paper is to investigate the issues in managing oil palm plantation from the view of oil palm manager by interview. The results from this interview will helps in identifying the suitable issues could be highlight in implementing online 3D visualization technique for oil palm plantation management.

Development of Oxidation Resistant Coatings on GRCop-84 Substrates by Cold Spray Process

NASA Technical Reports Server (NTRS)

Karthikeyan, J.

2007-01-01

GRCop-84, a Cu-CR-Nb alloy, has been developed for rocket engine liner applications. For maximum life additional oxidation protection is required to prevent blanching. NiCrAlY was identified as a suitable coating, and efforts were initiated to develop suitable coating techniques. Cold spray is one technique under consideration. Efforts at ASB Industries to produce dense, adherent coatings are detailed. The work culminated in the production of samples for testing at NASA Glenn Research Center.

INL’s TAP Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2017-06-22

The starting point for many consumer products is the industrial manufacture of platform chemicals. The recent boom in domestic shale gas production makes it possible to envision a new resource for chemical manufacturing. Catalysts are the accelerants behind most industrial chemical reactions. A sophisticated research technique using a Temporal Analysis of Products (or TAP) reactor can now help. By shedding light on a catalyst’s fundamental step-by-step process, a TAP reactor can help chemists and chemical engineers understand why a new catalyst works better in the lab than in the chemical plant.

Protein engineering for metabolic engineering: current and next-generation tools

PubMed Central

Marcheschi, Ryan J.; Gronenberg, Luisa S.; Liao, James C.

2014-01-01

Protein engineering in the context of metabolic engineering is increasingly important to the field of industrial biotechnology. As the demand for biologically-produced food, fuels, chemicals, food additives, and pharmaceuticals continues to grow, the ability to design and modify proteins to accomplish new functions will be required to meet the high productivity demands for the metabolism of engineered organisms. This article reviews advances of selecting, modeling, and engineering proteins to improve or alter their activity. Some of the methods have only recently been developed for general use and are just beginning to find greater application in the metabolic engineering community. We also discuss methods of generating random and targeted diversity in proteins to generate mutant libraries for analysis. Recent uses of these techniques to alter cofactor use, produce non-natural amino acids, alcohols, and carboxylic acids, and alter organism phenotypes are presented and discussed as examples of the successful engineering of proteins for metabolic engineering purposes. PMID:23589443

Protein engineering for metabolic engineering: current and next-generation tools.

PubMed

Marcheschi, Ryan J; Gronenberg, Luisa S; Liao, James C

2013-05-01

Protein engineering in the context of metabolic engineering is increasingly important to the field of industrial biotechnology. As the demand for biologically produced food, fuels, chemicals, food additives, and pharmaceuticals continues to grow, the ability to design and modify proteins to accomplish new functions will be required to meet the high productivity demands for the metabolism of engineered organisms. We review advances in selecting, modeling, and engineering proteins to improve or alter their activity. Some of the methods have only recently been developed for general use and are just beginning to find greater application in the metabolic engineering community. We also discuss methods of generating random and targeted diversity in proteins to generate mutant libraries for analysis. Recent uses of these techniques to alter cofactor use; produce non-natural amino acids, alcohols, and carboxylic acids; and alter organism phenotypes are presented and discussed as examples of the successful engineering of proteins for metabolic engineering purposes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Safe genetically engineered plants

NASA Astrophysics Data System (ADS)

Rosellini, D.; Veronesi, F.

2007-10-01

The application of genetic engineering to plants has provided genetically modified plants (GMPs, or transgenic plants) that are cultivated worldwide on increasing areas. The most widespread GMPs are herbicide-resistant soybean and canola and insect-resistant corn and cotton. New GMPs that produce vaccines, pharmaceutical or industrial proteins, and fortified food are approaching the market. The techniques employed to introduce foreign genes into plants allow a quite good degree of predictability of the results, and their genome is minimally modified. However, some aspects of GMPs have raised concern: (a) control of the insertion site of the introduced DNA sequences into the plant genome and of its mutagenic effect; (b) presence of selectable marker genes conferring resistance to an antibiotic or an herbicide, linked to the useful gene; (c) insertion of undesired bacterial plasmid sequences; and (d) gene flow from transgenic plants to non-transgenic crops or wild plants. In response to public concerns, genetic engineering techniques are continuously being improved. Techniques to direct foreign gene integration into chosen genomic sites, to avoid the use of selectable genes or to remove them from the cultivated plants, to reduce the transfer of undesired bacterial sequences, and make use of alternative, safer selectable genes, are all fields of active research. In our laboratory, some of these new techniques are applied to alfalfa, an important forage plant. These emerging methods for plant genetic engineering are briefly reviewed in this work.

Progress in multidisciplinary design optimization at NASA Langley

NASA Technical Reports Server (NTRS)

Padula, Sharon L.

1993-01-01

Multidisciplinary Design Optimization refers to some combination of disciplinary analyses, sensitivity analysis, and optimization techniques used to design complex engineering systems. The ultimate objective of this research at NASA Langley Research Center is to help the US industry reduce the costs associated with development, manufacturing, and maintenance of aerospace vehicles while improving system performance. This report reviews progress towards this objective and highlights topics for future research. Aerospace design problems selected from the author's research illustrate strengths and weaknesses in existing multidisciplinary optimization techniques. The techniques discussed include multiobjective optimization, global sensitivity equations and sequential linear programming.

Industrial and Systems Engineering Applications in NASA

NASA Technical Reports Server (NTRS)

Shivers, Charles H.

2006-01-01

A viewgraph presentation on the many applications of Industrial and Systems Engineering used for safe NASA missions is shown. The topics include: 1) NASA Information; 2) Industrial Engineering; 3) Systems Engineering; and 4) Major NASA Programs.

System safety education focused on industrial engineering

NASA Technical Reports Server (NTRS)

Johnston, W. L.; Morris, R. S.

1971-01-01

An educational program, designed to train students with the specific skills needed to become safety specialists, is described. The discussion concentrates on application, selection, and utilization of various system safety analytical approaches. Emphasis is also placed on the management of a system safety program, its relationship with other disciplines, and new developments and applications of system safety techniques.

Biotechnology, Genetic Engineering and Society. Monograph Series: III.

ERIC Educational Resources Information Center

Kieffer, George H.

New techniques have expanded the field of biotechnology and awarded scientists an unprecedented degree of control over the genetic constitutions of living things. The knowledge of DNA science is the basis for this burgeoning industry which may be a major force in human existence. Just as it is possible to move genetic material from one organism to…

Enabling plant synthetic biology through genome engineering.

PubMed

Baltes, Nicholas J; Voytas, Daniel F

2015-02-01

Synthetic biology seeks to create new biological systems, including user-designed plants and plant cells. These systems can be employed for a variety of purposes, ranging from producing compounds of industrial or therapeutic value, to reducing crop losses by altering cellular responses to pathogens or climate change. To realize the full potential of plant synthetic biology, techniques are required that provide control over the genetic code - enabling targeted modifications to DNA sequences within living plant cells. Such control is now within reach owing to recent advances in the use of sequence-specific nucleases to precisely engineer genomes. We discuss here the enormous potential provided by genome engineering for plant synthetic biology. Copyright © 2014 Elsevier Ltd. All rights reserved.

Status review of NASA programs for reducing aircraft gas turbine engine emissions

NASA Technical Reports Server (NTRS)

Rudey, R. A.

1976-01-01

The paper describes and discusses the results from some of the research and development programs for reducing aircraft gas turbine engine emissions. Although the paper concentrates on NASA programs only, work supported by other U.S. government agencies and industry has provided considerable data on low emission advanced technology for aircraft gas turbine engine combustors. The results from the two major NASA technology development programs, the ECCP (Experimental Clean Combustor Program) and the PRTP (Pollution Reduction Technology Program), are presented and compared with the requirements of the 1979 U.S. EPA standards. Emission reduction techniques currently being evaluated in these programs are described along with the results and a qualitative assessment of development difficulty.

FY2015 Annual Report for Alternative Fuels DISI Engine Research.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjöberg, Carl-Magnus G.

2016-01-01

Climate change and the need to secure energy supplies are two reasons for a growing interest in engine efficiency and alternative fuels. This project contributes to the science-base needed by industry to develop highly efficient DISI engines that also beneficially exploit the different properties of alternative fuels. Our emphasis is on lean operation, which can provide higher efficiencies than traditional non-dilute stoichiometric operation. Since lean operation can lead to issues with ignition stability, slow flame propagation and low combustion efficiency, we focus on techniques that can overcome these challenges. Specifically, fuel stratification is used to ensure ignition and completeness ofmore » combustion but has soot- and NOx- emissions challenges. For ultralean well-mixed operation, turbulent deflagration can be combined with controlled end-gas auto-ignition to render mixed-mode combustion that facilitates high combustion efficiency. However, the response of both combustion and exhaust emissions to these techniques depends on the fuel properties. Therefore, to achieve optimal fuel-economy gains, the engine combustion-control strategies must be adapted to the fuel being utilized.« less

Plant-Wide Assessment Report for Shaw Industries, Plant #78; Aiken, SC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michael Brown PE, CEM; Matt Soderlund; Bill Meffert PE

A plant-wide energy assessment sponsored by the U.S. Department of Energy was conducted at Shaw Industries Group, plant #78 in Aiken, SC. The assessment team consisted of Georgia Tech faculty from the Energy & Environmental Management Center and Shaw personnel from plant #78 and the corporate energy group. The purpose of this assessment was to uncover as many opportunities for saving energy usage and costs using techniques that have been established as best practices in the energy engineering field. In addition, these findings are to be shared with similar plants in Shaw Industries Group to multiply the lessons learned. Themore » findings from this assessment are included in this report.« less

Discovery, Molecular Mechanisms, and Industrial Applications of Cold-Active Enzymes

PubMed Central

Santiago, Margarita; Ramírez-Sarmiento, César A.; Zamora, Ricardo A.; Parra, Loreto P.

2016-01-01

Cold-active enzymes constitute an attractive resource for biotechnological applications. Their high catalytic activity at temperatures below 25°C makes them excellent biocatalysts that eliminate the need of heating processes hampering the quality, sustainability, and cost-effectiveness of industrial production. Here we provide a review of the isolation and characterization of novel cold-active enzymes from microorganisms inhabiting different environments, including a revision of the latest techniques that have been used for accomplishing these paramount tasks. We address the progress made in the overexpression and purification of cold-adapted enzymes, the evolutionary and molecular basis of their high activity at low temperatures and the experimental and computational techniques used for their identification, along with protein engineering endeavors based on these observations to improve some of the properties of cold-adapted enzymes to better suit specific applications. We finally focus on examples of the evaluation of their potential use as biocatalysts under conditions that reproduce the challenges imposed by the use of solvents and additives in industrial processes and of the successful use of cold-adapted enzymes in biotechnological and industrial applications. PMID:27667987

Discovery, Molecular Mechanisms, and Industrial Applications of Cold-Active Enzymes.

PubMed

Santiago, Margarita; Ramírez-Sarmiento, César A; Zamora, Ricardo A; Parra, Loreto P

2016-01-01

Cold-active enzymes constitute an attractive resource for biotechnological applications. Their high catalytic activity at temperatures below 25°C makes them excellent biocatalysts that eliminate the need of heating processes hampering the quality, sustainability, and cost-effectiveness of industrial production. Here we provide a review of the isolation and characterization of novel cold-active enzymes from microorganisms inhabiting different environments, including a revision of the latest techniques that have been used for accomplishing these paramount tasks. We address the progress made in the overexpression and purification of cold-adapted enzymes, the evolutionary and molecular basis of their high activity at low temperatures and the experimental and computational techniques used for their identification, along with protein engineering endeavors based on these observations to improve some of the properties of cold-adapted enzymes to better suit specific applications. We finally focus on examples of the evaluation of their potential use as biocatalysts under conditions that reproduce the challenges imposed by the use of solvents and additives in industrial processes and of the successful use of cold-adapted enzymes in biotechnological and industrial applications.

Comparison of commercial analytical techniques for measuring chlorine dioxide in urban desalinated drinking water.

PubMed

Ammar, T A; Abid, K Y; El-Bindary, A A; El-Sonbati, A Z

2015-12-01

Most drinking water industries are closely examining options to maintain a certain level of disinfectant residual through the entire distribution system. Chlorine dioxide is one of the promising disinfectants that is usually used as a secondary disinfectant, whereas the selection of the proper monitoring analytical technique to ensure disinfection and regulatory compliance has been debated within the industry. This research endeavored to objectively compare the performance of commercially available analytical techniques used for chlorine dioxide measurements (namely, chronoamperometry, DPD (N,N-diethyl-p-phenylenediamine), Lissamine Green B (LGB WET) and amperometric titration), to determine the superior technique. The commonly available commercial analytical techniques were evaluated over a wide range of chlorine dioxide concentrations. In reference to pre-defined criteria, the superior analytical technique was determined. To discern the effectiveness of such superior technique, various factors, such as sample temperature, high ionic strength, and other interferences that might influence the performance were examined. Among the four techniques, chronoamperometry technique indicates a significant level of accuracy and precision. Furthermore, the various influencing factors studied did not diminish the technique's performance where it was fairly adequate in all matrices. This study is a step towards proper disinfection monitoring and it confidently assists engineers with chlorine dioxide disinfection system planning and management.

Application of Terrestrial Laser Scanning to Study the Geometry of Slender Objects

NASA Astrophysics Data System (ADS)

Muszynski, Zbigniew; Milczarek, Wojciech

2017-12-01

Slender objects are a special group among the many types of industrial structures. These objects are characterized by a considerable height which is at least several times bigger than the diameter of the base. Mainly various types of industrial chimneys, as well as truss masts, towers, radio and television towers and also windmill columns belong to this group. During their operation slender objects are exposed to a number of unfavourable factors. For this reason, these objects require regular inspection, including geodetic measurements. In the paper the results of geodetic control of geometry of industrial chimney with a height of 120 m has been presented. The measurements were made by means of terrestrial laser scanning technique under rather unfavourable conditions (at night, during snowfall, with low air temperature) which allowed to verify the real usefulness and accuracy of this technique in engineering practice. On the basis of point cloud, the values of deviations from the vertical for main axis of the chimney have been calculated. Using point cloud, the selected horizontal cross sections of chimney were analysed and were compared with the archival geodetic documentation. On this basis the final conclusions about the advantages and limitations of the using of terrestrial laser scanning technique for the control of geometry of high industrial chimneys have been formulated.

CT-assisted agile manufacturing

NASA Astrophysics Data System (ADS)

Stanley, James H.; Yancey, Robert N.

1996-11-01

The next century will witness at least two great revolutions in the way goods are produced. First, workers will use the medium of virtual reality in all aspects of marketing, research, development, prototyping, manufacturing, sales and service. Second, market forces will drive manufacturing towards small-lot production and just-in-time delivery. Already, we can discern the merging of these megatrends into what some are calling agile manufacturing. Under this new paradigm, parts and processes will be designed and engineered within the mind of a computer, tooled and manufactured by the offspring of today's rapid prototyping equipment, and evaluated for performance and reliability by advanced nondestructive evaluation (NDE) techniques and sophisticated computational models. Computed tomography (CT) is the premier example of an NDE method suitable for future agile manufacturing activities. It is the only modality that provides convenient access to the full suite of engineering data that users will need to avail themselves of computer- aided design, computer-aided manufacturing, and computer- aided engineering capabilities, as well as newly emerging reverse engineering, rapid prototyping and solid freeform fabrication technologies. As such, CT is assured a central, utilitarian role in future industrial operations. An overview of this exciting future for industrial CT is presented.

Data Documentation for Navy Civilian Manpower Study,

DTIC Science & Technology

1986-09-01

Engineering 0830 Mechanical Engineer 0840 Nuclear Engineering 0850 Electrical Engineering 0855 Electronics Engineering 0856 Electronics ...OCCUPATIONAL LEVEL (DONOL) CODES DONOL code Title 1060 Engineering Drafting 1061 Electronics Technician w 1062 Engineering Technician 1063 Industrial...Architect 2314 Electrical Engineer 2315 Electronic Engineer 2316 Industrial Engineer 2317 Mechanical Engineer 2318

Some Interesting Applications of Probabilistic Techiques in Structural Dynamic Analysis of Rocket Engines

NASA Technical Reports Server (NTRS)

Brown, Andrew M.

2014-01-01

Numerical and Analytical methods developed to determine damage accumulation in specific engine components when speed variation included. Dither Life Ratio shown to be well over factor of 2 for specific example. Steady-State assumption shown to be accurate for most turbopump cases, allowing rapid calculation of DLR. If hot-fire speed data unknown, Monte Carlo method developed that uses speed statistics for similar engines. Application of techniques allow analyst to reduce both uncertainty and excess conservatism. High values of DLR could allow previously unacceptable part to pass HCF criteria without redesign. Given benefit and ease of implementation, recommend that any finite life turbomachine component analysis adopt these techniques. Probability Values calculated, compared, and evaluated for several industry-proposed methods for combining random and harmonic loads. Two new excel macros written to calculate combined load for any specific probability level. Closed form Curve fits generated for widely used 3(sigma) and 2(sigma) probability levels. For design of lightweight aerospace components, obtaining accurate, reproducible, statistically meaningful answer critical.

On hydrophilicity improvement of the porous anodic alumina film by hybrid nano/micro structuring

NASA Astrophysics Data System (ADS)

Wang, Weichao; Zhao, Wei; Wang, Kaige; Wang, Lei; Wang, Xuewen; Wang, Shuang; Zhang, Chen; Bai, Jintao

2017-09-01

In both, laboratory and industry, tremendous attention is paid to discover an effective technique to produce uniform, controllable and (super) hydrophilic surfaces over large areas that are useful in a wide range of applications. In this investigation, by combing porous anodic alumina (PAA) film with nano-structures and microarray of aluminum, the hydrophilicity of hybrid nano-micro structure has been significantly improved. It is found some factors can affect the hydrophilicity of film, such as the size and aspect ratio of microarray, the thickness of nano-PAA film etc. Comparing with pure nano-PAA films and microarray, the hybrid nano-micro structure can provide uniform surface with significantly better hydrophilicity. The improvement can be up to 84%. Also, this technique exhibits good stability and repeatability for industrial production. By optimizing the thickness of nano-PAA film and aspect ratio of micro-structures, super-hydrophilicity can be reached. This study has obvious prospect in the fields of chemical industry, biomedical engineering and lab-on-a-chip applications.

Recent Progress on Systems and Synthetic Biology Approaches to Engineer Fungi As Microbial Cell Factories.

PubMed

Amores, Gerardo Ruiz; Guazzaroni, María-Eugenia; Arruda, Letícia Magalhães; Silva-Rocha, Rafael

2016-04-01

Filamentous fungi are remarkable organisms naturally specialized in deconstructing plant biomass and this feature has a tremendous potential for biofuel production from renewable sources. The past decades have been marked by a remarkable progress in the genetic engineering of fungi to generate industry-compatible strains needed for some biotech applications. In this sense, progress in this field has been marked by the utilization of high-throughput techniques to gain deep understanding of the molecular machinery controlling the physiology of these organisms, starting thus the Systems Biology era of fungi. Additionally, genetic engineering has been extensively applied to modify wellcharacterized promoters in order to construct new expression systems with enhanced performance under the conditions of interest. In this review, we discuss some aspects related to significant progress in the understating and engineering of fungi for biotechnological applications, with special focus on the construction of synthetic promoters and circuits in organisms relevant for industry. Different engineering approaches are shown, and their potential and limitations for the construction of complex synthetic circuits in these organisms are examined. Finally, we discuss the impact of engineered promoter architecture in the single-cell behavior of the system, an often-neglected relationship with a tremendous impact in the final performance of the process of interest. We expect to provide here some new directions to drive future research directed to the construction of high-performance, engineered fungal strains working as microbial cell factories.

Handbook of Industrial Engineering Equations, Formulas, and Calculations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Badiru, Adedeji B; Omitaomu, Olufemi A

The first handbook to focus exclusively on industrial engineering calculations with a correlation to applications, Handbook of Industrial Engineering Equations, Formulas, and Calculations contains a general collection of the mathematical equations often used in the practice of industrial engineering. Many books cover individual areas of engineering and some cover all areas, but none covers industrial engineering specifically, nor do they highlight topics such as project management, materials, and systems engineering from an integrated viewpoint. Written by acclaimed researchers and authors, this concise reference marries theory and practice, making it a versatile and flexible resource. Succinctly formatted for functionality, the bookmore » presents: Basic Math Calculations; Engineering Math Calculations; Production Engineering Calculations; Engineering Economics Calculations; Ergonomics Calculations; Facility Layout Calculations; Production Sequencing and Scheduling Calculations; Systems Engineering Calculations; Data Engineering Calculations; Project Engineering Calculations; and Simulation and Statistical Equations. It has been said that engineers make things while industrial engineers make things better. To make something better requires an understanding of its basic characteristics and the underlying equations and calculations that facilitate that understanding. To do this, however, you do not have to be computational experts; you just have to know where to get the computational resources that are needed. This book elucidates the underlying equations that facilitate the understanding required to improve design processes, continuously improving the answer to the age-old question: What is the best way to do a job?« less

Viewing the Reviewing: An Observational Study of the Use of an Interactive Digital Video To Help Teach the Concepts of Design Inspection Reviews.

ERIC Educational Resources Information Center

Love, Matthew

"Design Inspection Reviews" are structured meetings in which participants follow certain rules of procedure and behavior when conducting detailed readings of design plans to identify errors and misunderstandings. The technique is widely used in the software engineering industry, where it is demonstrably more effective than testing at…

Industrial Scale Synthesis of Carbon Nanotubes Via Fluidized Bed Chemical Vapor Deposition: A Senior Design Project

ERIC Educational Resources Information Center

Smith, York R.; Fuchs, Alan; Meyyappan, M.

2010-01-01

Senior year chemical engineering students designed a process to produce 10 000 tonnes per annum of single wall carbon nanotubes (SWNT) and also conducted bench-top experiments to synthesize SWNTs via fluidized bed chemical vapor deposition techniques. This was an excellent pedagogical experience because it related to the type of real world design…

What Does CALL Have to Offer Computer Science and What Does Computer Science Have to Offer CALL?

ERIC Educational Resources Information Center

Cushion, Steve

2006-01-01

We will argue that CALL can usefully be viewed as a subset of computer software engineering and can profit from adopting some of the recent progress in software development theory. The unified modelling language has become the industry standard modelling technique and the accompanying unified process is rapidly gaining acceptance. The manner in…

Utilization of Negative Ion ESI-MS and Tandem Mass Spectrometry to Detect and Confirm the NADH-Boric Acid Complex

ERIC Educational Resources Information Center

Kim, Danny H.; Eckhert, Curtis D.; Faull, Kym F.

2011-01-01

Mass spectrometry (MS) is a powerful analytical technique that is now widely used in the chemical, physical, engineering, and life sciences, with rapidly growing applications in many areas including clinical, forensic, pharmaceutical, and environmental fields. The increase in use of MS in both academic and industrial settings for research and…

Guidelines for safe handling, use and disposal of nanoparticles

NASA Astrophysics Data System (ADS)

Amoabediny, G. H.; Naderi, A.; Malakootikhah, J.; Koohi, M. K.; Mortazavi, S. A.; Naderi, M.; Rashedi, H.

2009-05-01

Health, safety and environmental (HSE) risks of a technology is an inseparable part of it which threatens all exposed employees. It has been proved for many years that exposure to particles, in an occupational setting, could be linked with the onset of lung diseases, such as pneumoconiosis, chronic obstructive pulmonary disease (COPD), and mesotelioma and lung cancer. Nanoparticles, due to their unique characteristics including; small size, shape, high surface area, charge, chemical properties, solubility, and degree of agglomeration can cross cell boundaries or pass directly from the lungs into the blood stream and ultimately reach to all of the organs in the body. This is the reason why they may pose higher risk than the same mass and material of larger particles. Moreover, biodegradation of nanoparticles by some kinds of fungi (like wood decay fungi) may result in metabolites which may be toxic to microorganisms under aerobic and anaerobic conditions. Bacteria and living cells can take up nanoparticles, providing the basis for potential bioaccumulation in the food chain. Considering Iran's prominent position in nanotechnologies and fast-growing in research and industrial activities, controlling nanoparticles related HSE risks should be highly considered. In general, there are three main approaches to risk and exposure control: engineering techniques, administrative means and personal protective equipments. These complementary approaches especially engineering techniques should be considered starting with the design stage of an industrial process. Administrative means of control constitute an additional approach when the other methods have not achieved the expected control levels. Administrative means of control must never substitute for engineering techniques, which always be performed according to standard practices. In some situations, due to insufficiently advanced technology and prohibitive costs, engineering measerus can not be implemended. In these situations, performing administrative means of control constitute other ways of limiaiting the occupational exposure risks. Accordingly, to minimize the risks from know and unknown health, safety and invironment hazards in research and occupational setting of the country, guideline for safe handling, use and disposal of manopractical has provided.

Controlled Positioning of Cells in Biomaterials—Approaches Towards 3D Tissue Printing

PubMed Central

Wüst, Silke; Müller, Ralph; Hofmann, Sandra

2011-01-01

Current tissue engineering techniques have various drawbacks: they often incorporate uncontrolled and imprecise scaffold geometries, whereas the current conventional cell seeding techniques result mostly in random cell placement rather than uniform cell distribution. For the successful reconstruction of deficient tissue, new material engineering approaches have to be considered to overcome current limitations. An emerging method to produce complex biological products including cells or extracellular matrices in a controlled manner is a process called bioprinting or biofabrication, which effectively uses principles of rapid prototyping combined with cell-loaded biomaterials, typically hydrogels. 3D tissue printing is an approach to manufacture functional tissue layer-by-layer that could be transplanted in vivo after production. This method is especially advantageous for stem cells since a controlled environment can be created to influence cell growth and differentiation. Using printed tissue for biotechnological and pharmacological needs like in vitro drug-testing may lead to a revolution in the pharmaceutical industry since animal models could be partially replaced by biofabricated tissues mimicking human physiology and pathology. This would not only be a major advancement concerning rising ethical issues but would also have a measureable impact on economical aspects in this industry of today, where animal studies are very labor-intensive and therefore costly. In this review, current controlled material and cell positioning techniques are introduced highlighting approaches towards 3D tissue printing. PMID:24956301

Controlled Positioning of Cells in Biomaterials-Approaches Towards 3D Tissue Printing.

PubMed

Wüst, Silke; Müller, Ralph; Hofmann, Sandra

2011-08-04

Current tissue engineering techniques have various drawbacks: they often incorporate uncontrolled and imprecise scaffold geometries, whereas the current conventional cell seeding techniques result mostly in random cell placement rather than uniform cell distribution. For the successful reconstruction of deficient tissue, new material engineering approaches have to be considered to overcome current limitations. An emerging method to produce complex biological products including cells or extracellular matrices in a controlled manner is a process called bioprinting or biofabrication, which effectively uses principles of rapid prototyping combined with cell-loaded biomaterials, typically hydrogels. 3D tissue printing is an approach to manufacture functional tissue layer-by-layer that could be transplanted in vivo after production. This method is especially advantageous for stem cells since a controlled environment can be created to influence cell growth and differentiation. Using printed tissue for biotechnological and pharmacological needs like in vitro drug-testing may lead to a revolution in the pharmaceutical industry since animal models could be partially replaced by biofabricated tissues mimicking human physiology and pathology. This would not only be a major advancement concerning rising ethical issues but would also have a measureable impact on economical aspects in this industry of today, where animal studies are very labor-intensive and therefore costly. In this review, current controlled material and cell positioning techniques are introduced highlighting approaches towards 3D tissue printing.

Service Modeling for Service Engineering

NASA Astrophysics Data System (ADS)

Shimomura, Yoshiki; Tomiyama, Tetsuo

Intensification of service and knowledge contents within product life cycles is considered crucial for dematerialization, in particular, to design optimal product-service systems from the viewpoint of environmentally conscious design and manufacturing in advanced post industrial societies. In addition to the environmental limitations, we are facing social limitations which include limitations of markets to accept increasing numbers of mass-produced artifacts and such environmental and social limitations are restraining economic growth. To attack and remove these problems, we need to reconsider the current mass production paradigm and to make products have more added values largely from knowledge and service contents to compensate volume reduction under the concept of dematerialization. Namely, dematerialization of products needs to enrich service contents. However, service was mainly discussed within marketing and has been mostly neglected within traditional engineering. Therefore, we need new engineering methods to look at services, rather than just functions, called "Service Engineering." To establish service engineering, this paper proposes a modeling technique of service.

Future heavy duty trucking engine requirements

NASA Technical Reports Server (NTRS)

Strawhorn, L. W.; Suski, V. A.

1985-01-01

Developers of advanced heavy duty diesel engines are engaged in probing the opportunities presented by new materials and techniques. This process is technology driven, but there is neither assurance that the eventual users of the engines so developed will be comfortable with them nor, indeed, that those consumers will continue to exist in either the same form, or numbers as they do today. To ensure maximum payoff of research dollars, the equipment development process must consider user needs. This study defines motor carrier concerns, cost tolerances, and the engine parameters which match the future projected industry needs. The approach taken to do that is to be explained and the results presented. The material to be given comes basically from a survey of motor carrier fleets. It provides indications of the role of heavy duty vehicles in the 1998 period and their desired maintenance and engine performance parameters.

Research and application of microbial enzymes--India's contribution.

PubMed

Chand, Subhash; Mishra, Prashant

2003-01-01

Enzymes have attracted the attention of scientists world over due to their wide range of physiological, analytical and industrial applications. Although enzymes have been isolated, purified and studied from microbial, animal and plant sources, microorganisms represent the most common source of enzymes due to their broad biochemical diversity, feasibility of mass culture and ease of genetic manipulation. With the advent of molecular biology techniques, a number of genes of industrially important enzymes has been cloned and expressed in order to improve the production of enzymes, substrate utilization and other commercially useful properties. Special attention has been focused on enzymes isolated from thermophiles due to their inherent stability and industrial applications. In addition, a variety of methods have been employed to modify enzymes for their industrial usage including strain improvement, chemical modifications, modification of reaction environment, immobilization and protein engineering. A wide range of applications of enzymes in different bioprocess industries is discussed.

NASA Workshop on Hybrid (Mixed-Actuator) Spacecraft Attitude Control

NASA Technical Reports Server (NTRS)

Dennehy, Cornelius J.; Kunz, Nans

2014-01-01

At the request of the Science Mission Directorate Chief Engineer, the NASA Technical Fellow for Guidance, Navigation & Control assembled and facilitated a workshop on Spacecraft Hybrid Attitude Control. This multi-Center, academic, and industry workshop, sponsored by the NASA Engineering and Safety Center (NESC), was held in April 2013 to unite nationwide experts to present and discuss the various innovative solutions, techniques, and lessons learned regarding the development and implementation of the various hybrid attitude control system solutions investigated or implemented. This report attempts to document these key lessons learned with the 16 findings and 9 NESC recommendations.

Transient Phenomena in Multiphase and Multicomponent Systems: Research Report

NASA Astrophysics Data System (ADS)

Zur Beurteilung von Stoffen in der Landwirtschaft, Senatskommission

2000-09-01

Due to the reinforced risk and safety-analysis of industrial plants in chemical and energy-engineering there has been increased demand in industry for more information on thermo- and fluiddynamic effects of non-equilibria during strong transients. Therefore, the 'Deutsche Forschungsgemeinschaft' initiated a special research program focusing on the study of transient phenomena in multiphase systems with one or several components. This book describes macroscopic as well as microscopic transient situations. A large part of the book deals with numerical methods for describing transients in two-phase mixtures. New developments in measuring techniques are also presented.

Risk Management Technique for design and operation of facilities and equipment

NASA Technical Reports Server (NTRS)

Fedor, O. H.; Parsons, W. N.; Coutinho, J. De S.

1975-01-01

The Risk Management System collects information from engineering, operating, and management personnel to identify potentially hazardous conditions. This information is used in risk analysis, problem resolution, and contingency planning. The resulting hazard accountability system enables management to monitor all identified hazards. Data from this system are examined in project reviews so that management can decide to eliminate or accept these risks. This technique is particularly effective in improving the management of risks in large, complex, high-energy facilities. These improvements are needed for increased cooperation among industry, regulatory agencies, and the public.

Quantitative ultrasonic evaluation of engineering properties in metals, composites and ceramics

NASA Technical Reports Server (NTRS)

Vary, A.

1980-01-01

Ultrasonic technology from the perspective of nondestructive evaluation approaches to material strength prediction and property verification is reviewed. Emergent advanced technology involving quantitative ultrasonic techniques for materials characterization is described. Ultrasonic methods are particularly useful in this area because they involve mechanical elastic waves that are strongly modulated by the same morphological factors that govern mechanical strength and dynamic failure processes. It is emphasized that the technology is in its infancy and that much effort is still required before all the available techniques can be transferred from laboratory to industrial environments.

Electrical Resistivity Measurements: a Review

NASA Astrophysics Data System (ADS)

Singh, Yadunath

World-wide interest on the use of ceramic materials for aerospace and other advanced engineering applications, has led to the need for inspection techniques capable of detecting unusually electrical and thermal anomalies in these compounds. Modern ceramic materials offer many attractive physical, electrical and mechanical properties for a wide and rapidly growing range of industrial applications; moreover specific use may be made of their electrical resistance, chemical resistance, and thermal barrier properties. In this review, we report the development and various techniques for the resistivity measurement of solid kind of samples.

CRISPR Mediated Genome Engineering and its Application in Industry.

PubMed

Kaboli, Saeed; Babazada, Hasan

2018-01-01

The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR-associated nuclease 9) method has been dramatically changing the field of genome engineering. It is a rapid, highly efficient and versatile tool for precise modification of genome that uses a guide RNA (gRNA) to target Cas9 to a specific sequence. This novel RNA-guided genome-editing technique has become a revolutionary tool in biomedical science and has many innovative applications in different fields. In this review, we briefly introduce the Cas9-mediated genome-editing tool, summarize the recent advances in CRISPR/Cas9 technology to engineer the genomes of a wide variety of organisms, and discuss their applications to treatment of fungal and viral disease. We also discuss advantageous of CRISPR/Cas9 technology to drug design, creation of animal model, and to food, agricultural and energy sciences. Adoption of the CRISPR/Cas9 technology in biomedical and biotechnological researches would create innovative applications of it not only for breeding of strains exhibiting desired traits for specific industrial and medical applications, but also for investigation of genome function.

Challenges in industrial fermentation technology research.

PubMed

Formenti, Luca Riccardo; Nørregaard, Anders; Bolic, Andrijana; Hernandez, Daniela Quintanilla; Hagemann, Timo; Heins, Anna-Lena; Larsson, Hilde; Mears, Lisa; Mauricio-Iglesias, Miguel; Krühne, Ulrich; Gernaey, Krist V

2014-06-01

Industrial fermentation processes are increasingly popular, and are considered an important technological asset for reducing our dependence on chemicals and products produced from fossil fuels. However, despite their increasing popularity, fermentation processes have not yet reached the same maturity as traditional chemical processes, particularly when it comes to using engineering tools such as mathematical models and optimization techniques. This perspective starts with a brief overview of these engineering tools. However, the main focus is on a description of some of the most important engineering challenges: scaling up and scaling down fermentation processes, the influence of morphology on broth rheology and mass transfer, and establishing novel sensors to measure and control insightful process parameters. The greatest emphasis is on the challenges posed by filamentous fungi, because of their wide applications as cell factories and therefore their relevance in a White Biotechnology context. Computational fluid dynamics (CFD) is introduced as a promising tool that can be used to support the scaling up and scaling down of bioreactors, and for studying mixing and the potential occurrence of gradients in a tank. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

48 CFR 6.302-3 - Industrial mobilization; engineering, developmental, or research capability; or expert services.

Code of Federal Regulations, 2011 CFR

2011-10-01

...; engineering, developmental, or research capability; or expert services. 6.302-3 Section 6.302-3 Federal... Other Than Full and Open Competition 6.302-3 Industrial mobilization; engineering, developmental, or... achieve industrial mobilization, (ii) To establish or maintain an essential engineering, research, or...

48 CFR 6.302-3 - Industrial mobilization; engineering, developmental, or research capability; or expert services.

Code of Federal Regulations, 2010 CFR

2010-10-01

...; engineering, developmental, or research capability; or expert services. 6.302-3 Section 6.302-3 Federal... Other Than Full and Open Competition 6.302-3 Industrial mobilization; engineering, developmental, or... achieve industrial mobilization, (ii) To establish or maintain an essential engineering, research, or...

48 CFR 6.302-3 - Industrial mobilization; engineering, developmental, or research capability; or expert services.

Code of Federal Regulations, 2013 CFR

2013-10-01

...; engineering, developmental, or research capability; or expert services. 6.302-3 Section 6.302-3 Federal... Other Than Full and Open Competition 6.302-3 Industrial mobilization; engineering, developmental, or... achieve industrial mobilization, (ii) To establish or maintain an essential engineering, research, or...

48 CFR 6.302-3 - Industrial mobilization; engineering, developmental, or research capability; or expert services.

Code of Federal Regulations, 2014 CFR

2014-10-01

...; engineering, developmental, or research capability; or expert services. 6.302-3 Section 6.302-3 Federal... Other Than Full and Open Competition 6.302-3 Industrial mobilization; engineering, developmental, or... achieve industrial mobilization, (ii) To establish or maintain an essential engineering, research, or...

48 CFR 6.302-3 - Industrial mobilization; engineering, developmental, or research capability; or expert services.

Code of Federal Regulations, 2012 CFR

2012-10-01

...; engineering, developmental, or research capability; or expert services. 6.302-3 Section 6.302-3 Federal... Other Than Full and Open Competition 6.302-3 Industrial mobilization; engineering, developmental, or... achieve industrial mobilization, (ii) To establish or maintain an essential engineering, research, or...

46 CFR 11.530 - Endorsements as engineers of uninspected fishing industry vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Endorsements as engineers of uninspected fishing... Engineer Officer Endorsements § 11.530 Endorsements as engineers of uninspected fishing industry vessels... propelled, which are documented to engage in the fishing industry, with the exception of— (1) Wooden ships...

[Improving industrial microbial stress resistance by metabolic engineering: a review].

PubMed

Fu, Ruiyan; Li, Yin

2010-09-01

Metabolic engineering is a technologic platform for industrial strain improvement and aims not only at modifying microbial metabolic fluxes, but also improving the physiological performance of industrial microbes. Microbes will meet multiple stresses in industrial processes. Consequently, elicited gene responses might result in a decrease in overall cell fitness and the efficiency of biotransformation. Thus, it is crucial to develop robust and productive microbial strains that can be integrated into industrial-scale bioprocesses. In this review, we focus on the progress of these novel methods and strategies for engineering stress-tolerance phenotypes referring to rational metabolic engineering and inverse metabolic engineering in recent years. In addition, we also address problems existing in this area and future research needs of microbial physiological functionality engineering.

Preparing systems engineering and computing science students in disciplined methods, quantitative, and advanced statistical techniques to improve process performance

NASA Astrophysics Data System (ADS)

McCray, Wilmon Wil L., Jr.

The research was prompted by a need to conduct a study that assesses process improvement, quality management and analytical techniques taught to students in U.S. colleges and universities undergraduate and graduate systems engineering and the computing science discipline (e.g., software engineering, computer science, and information technology) degree programs during their academic training that can be applied to quantitatively manage processes for performance. Everyone involved in executing repeatable processes in the software and systems development lifecycle processes needs to become familiar with the concepts of quantitative management, statistical thinking, process improvement methods and how they relate to process-performance. Organizations are starting to embrace the de facto Software Engineering Institute (SEI) Capability Maturity Model Integration (CMMI RTM) Models as process improvement frameworks to improve business processes performance. High maturity process areas in the CMMI model imply the use of analytical, statistical, quantitative management techniques, and process performance modeling to identify and eliminate sources of variation, continually improve process-performance; reduce cost and predict future outcomes. The research study identifies and provides a detail discussion of the gap analysis findings of process improvement and quantitative analysis techniques taught in U.S. universities systems engineering and computing science degree programs, gaps that exist in the literature, and a comparison analysis which identifies the gaps that exist between the SEI's "healthy ingredients " of a process performance model and courses taught in U.S. universities degree program. The research also heightens awareness that academicians have conducted little research on applicable statistics and quantitative techniques that can be used to demonstrate high maturity as implied in the CMMI models. The research also includes a Monte Carlo simulation optimization model and dashboard that demonstrates the use of statistical methods, statistical process control, sensitivity analysis, quantitative and optimization techniques to establish a baseline and predict future customer satisfaction index scores (outcomes). The American Customer Satisfaction Index (ACSI) model and industry benchmarks were used as a framework for the simulation model.

Can crystal engineering be as beneficial as micronisation and overcome its pitfalls?: A case study with cilostazol.

PubMed

Sai Gouthami, Kodukula; Kumar, Dinesh; Thipparaboina, Rajesh; Chavan, Rahul B; Shastri, Nalini R

2015-08-01

Improvement in dissolution of the drugs having poor solubility is a challenge in pharmaceutical industry. Micronization is one technique, employed for dissolution enhancement of cilostazol, a BCS class II drug. However, the obtained micronized drug possesses poor flowability. The aim of this study was to improve the dissolution rate and flow properties of cilostazol by crystal engineering, using habit modification method and compare with micronized cilostazol bulk drug. Simulation studies were performed to predict the effect of solvents on cilostazol crystal habit. Cilostazol crystals with different habits were prepared by solvent:anti-solvent crystallization technique. SEM, FTIR, DSC, TGA and PXRD were used for solid state characterization. The results revealed that cilostazol re-crystallized from methanol-hexane system were hexagonal and ethanol-hexane system gave rods. Cilostazol engineered habits showed increased dissolution rate than unprocessed drug but similar dissolution rate when compared to micronized cilostazol. Micronized cilostazol showed a dissolution efficiency of 75.58% where as cilostazol recrystallized from methanol-hexane and ethanol-hexane systems resulted in a dissolution efficiency of 72.63% and 68.63%, respectively. In addition, crystal engineering resulted in improved flow properties of re-crystallized habits when compared to micronized form of the drug. In conclusion, crystal engineering by habit modification show potential for dissolution enhancement with an added advantage of improved flow properties over micronization technique, for poorly soluble drugs like cilostazol. Copyright © 2015 Elsevier B.V. All rights reserved.

Model-based Acceleration Control of Turbofan Engines with a Hammerstein-Wiener Representation

NASA Astrophysics Data System (ADS)

Wang, Jiqiang; Ye, Zhifeng; Hu, Zhongzhi; Wu, Xin; Dimirovsky, Georgi; Yue, Hong

2017-05-01

Acceleration control of turbofan engines is conventionally designed through either schedule-based or acceleration-based approach. With the widespread acceptance of model-based design in aviation industry, it becomes necessary to investigate the issues associated with model-based design for acceleration control. In this paper, the challenges for implementing model-based acceleration control are explained; a novel Hammerstein-Wiener representation of engine models is introduced; based on the Hammerstein-Wiener model, a nonlinear generalized minimum variance type of optimal control law is derived; the feature of the proposed approach is that it does not require the inversion operation that usually upsets those nonlinear control techniques. The effectiveness of the proposed control design method is validated through a detailed numerical study.

Microbial Production of l-Serine from Renewable Feedstocks.

PubMed

Zhang, Xiaomei; Xu, Guoqiang; Shi, Jinsong; Koffas, Mattheos A G; Xu, Zhenghong

2018-07-01

l-Serine is a non-essential amino acid that has wide and expanding applications in industry with a fast-growing market demand. Currently, extraction and enzymatic catalysis are the main processes for l-serine production. However, such approaches limit the industrial-scale applications of this important amino acid. Therefore, shifting to the direct fermentative production of l-serine from renewable feedstocks has attracted increasing attention. This review details the current status of microbial production of l-serine from renewable feedstocks. We also summarize the current trends in metabolic engineering strategies and techniques for the typical industrial organisms Corynebacterium glutamicum and Escherichia coli that have been developed to address and overcome major challenges in the l-serine production process. Copyright © 2018 Elsevier Ltd. All rights reserved.

Polymer-Based Electrospun Nanofibers for Biomedical Applications

PubMed Central

Al-Enizi, Abdullah M.; Zagho, Moustafa M.

2018-01-01

Electrospinning has been considered a promising and novel procedure to fabricate polymer nanofibers due to its simplicity, cost effectiveness, and high production rate, making this technique highly relevant for both industry and academia. It is used to fabricate non-woven fibers with unique characteristics such as high permeability, stability, porosity, surface area to volume ratio, ease of functionalization, and excellent mechanical performance. Nanofibers can be synthesized and tailored to suit a wide range of applications including energy, biotechnology, healthcare, and environmental engineering. A comprehensive outlook on the recent developments, and the influence of electrospinning on biomedical uses such as wound dressing, drug release, and tissue engineering, has been presented. Concerns regarding the procedural restrictions and research contests are addressed, in addition to providing insights about the future of this fabrication technique in the biomedical field. PMID:29677145

Photo-irradiation paradigm: Mapping a remarkable facile technique used for advanced drug, gene and cell delivery.

PubMed

Shaker, Mohamed A; Younes, Husam M

2015-11-10

Undoubtedly, the progression of photo-irradiation technique has provided a smart engineering tool for the state-of-the-art biomaterials that guide the biomedical and therapeutic domains for promoting the modern pharmaceutical industry. Many investigators had exploited such a potential technique to create/ameliorate numerous pharmaceutical carriers. These carriers show promising applications that vary from small drug to therapeutic protein delivery and from gene to living cell encapsulation design. Harmony between the properties of precisely engineered precursors and the formed network structure broadens the investigator's intellect for both brilliant creations and effective applications. As well, controlling photo-curing at the formulation level, through manipulating the absorption of light stimuli, photoinitiator system and photo-responsive precursor, facilitates the exploration of novel distinctive biomaterials. Discussion of utilizing different photo-curing procedures in designing/formulation of different pharmaceutical carriers is the main emphasis of this review. In addition, recent applications of these intelligent techniques in targeted, controlled, and sustained drug delivery with understanding of photo-irradiation concept and mechanism are illustrated. Copyright © 2015 Elsevier B.V. All rights reserved.

Applications of Evolutionary Technology to Manufacturing and Logistics Systems : State-of-the Art Survey

NASA Astrophysics Data System (ADS)

Gen, Mitsuo; Lin, Lin

Many combinatorial optimization problems from industrial engineering and operations research in real-world are very complex in nature and quite hard to solve them by conventional techniques. Since the 1960s, there has been an increasing interest in imitating living beings to solve such kinds of hard combinatorial optimization problems. Simulating the natural evolutionary process of human beings results in stochastic optimization techniques called evolutionary algorithms (EAs), which can often outperform conventional optimization methods when applied to difficult real-world problems. In this survey paper, we provide a comprehensive survey of the current state-of-the-art in the use of EA in manufacturing and logistics systems. In order to demonstrate the EAs which are powerful and broadly applicable stochastic search and optimization techniques, we deal with the following engineering design problems: transportation planning models, layout design models and two-stage logistics models in logistics systems; job-shop scheduling, resource constrained project scheduling in manufacturing system.

DataView: a computational visualisation system for multidisciplinary design and analysis

NASA Astrophysics Data System (ADS)

Wang, Chengen

2016-01-01

Rapidly processing raw data and effectively extracting underlining information from huge volumes of multivariate data become essential to all decision-making processes in sectors like finance, government, medical care, climate analysis, industries, science, etc. Remarkably, visualisation is recognised as a fundamental technology that props up human comprehension, cognition and utilisation of burgeoning amounts of heterogeneous data. This paper presents a computational visualisation system, named DataView, which has been developed for graphically displaying and capturing outcomes of multiphysics problem-solvers widely used in engineering fields. The DataView is functionally composed of techniques for table/diagram representation, and graphical illustration of scalar, vector and tensor fields. The field visualisation techniques are implemented on the basis of a range of linear and non-linear meshes, which flexibly adapts to disparate data representation schemas adopted by a variety of disciplinary problem-solvers. The visualisation system has been successfully applied to a number of engineering problems, of which some illustrations are presented to demonstrate effectiveness of the visualisation techniques.

Foreign Outsourcing of the U.S. Electronics Industry

DTIC Science & Technology

1993-04-01

There is also great concern over the success of Japan and the "Asian Tigers" (Hong Kong, Korea, Malaysia , Singapore, and Taiwan) in capturing market share...Quality Management), JIT (Just In Time) inventory, MRP (Manufacturing Resources Planning), BPR (Business Process Reengineering), and EI ( Employee ...planning, business process re-engineering, employee empowering, just to name a few. All these techniques look to address the requirement to remain

Women in Engineering Program Advocates Network (WEPAN): Evaluation of the seventh annual conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brainard, S.G.

1996-08-01

The primary goals of the 1996 WEPAN Conference were to: (1) Conduct technical and programmatic seminars for institutions desiring to initiate, replicate, or expand women in engineering programs; (2) Provide assistance in fundraising and grant writing; (3) Profile women in engineering programs of excellence; (4) Sponsor inspiring, knowledgeable and motivational keynote speakers; and, (5) Offer a series of workshops focused on topics such as: establishing partnerships with industry, current research findings, retention strategies, issues affecting special populations, and early intervention techniques. In an effort to provide greater access for women to engineering careers, women in engineering program directors at Purduemore » University, Stevens Institute of Technology and the University of Washington joined together in 1990 to establish WEPAN, a national network of individuals interested in the recruitment, admission, retention, and graduation of women engineering students. This is the seventh year of operation. Success of this effort has been reflected in numerous ways: increased membership in the organization; increased number of women in engineering programs; increased number of women graduating in engineering; and grants from the U.S. Department of Energy, the National Science Foundation, the Alfred P. Sloan Foundation, the AT&T Foundation, and many other corporations to carry out the goals of WEPAN. The Seventh Annual Women in Engineering Conference entitled, Capitalizing on Today`s Challenges, was held in Denver, Colorado on June 1-4, 1996 at the Hyatt Regency. The conference brought together representatives from academia, government, and industry and examined current issues and initiatives for women in technology, science, and education. Building on the successes of the previous conferences, the seventh conference offered a new variety of speakers and topics.« less

Perspective on thermal barrier coatings for industrial gas turbine applications

NASA Technical Reports Server (NTRS)

Mutasim, Zaher; Brentnall, William

1995-01-01

Thermal barrier coatings (TBC's) have been used in high thrust aircraft engines for many years, and have proved to be very effective in providing thermal protection and increasing engine efficiencies. TBC life requirements for aircraft engines are typically less than those required for industrial gas turbines. This paper describes current and future applications of TBC's in industrial gas turbine engines. Early testing and applications of TBC's is reviewed. Areas of concern from the engine designer's and materials engineer's perspective are identified and evaluated. This paper focuses on the key factors that are expected to influence utilization of TBC's in advanced industrial gas turbine engines. It is anticipated that reliable, durable and highly effective coating systems will be produced that will ultimately improve engine efficiency and performance.

Trends in high power laser applications in civil engineering

NASA Astrophysics Data System (ADS)

Wignarajah, Sivakumaran; Sugimoto, Kenji; Nagai, Kaori

2005-03-01

This paper reviews the research and development efforts made on the use of lasers for material processing in the civil engineering industry. Initial investigations regarding the possibility of using lasers in civil engineering were made in the 1960s and '70s, the target being rock excavation. At that time however, the laser powers available were too small for any practical application utilization. In the 1980's, the technology of laser surface cleaning of historically important structures was developed in Europe. In the early 1990s, techniques of laser surface modification, including glazing and coloring of concrete, roughening of granite stones, carbonization of wood were pursued, mainly in Japan. In the latter part of the decade, techniques of laser decontamination of concrete surfaces in nuclear facilities were developed in many countries, and field tests were caried out in Japan. The rapid advances in development of diode lasers and YAG lasers with high power outputs and efficiencies since the late 1990's have led to a revival of worldwide interest in the use of lasers for material processing in civil engineering. The authors believe that, in the next 10 years or so, the advent of compact high power lasers is likely to lead to increased use of lasers of material processing in the field of civil engineering.

Enhancing Small-Business Opportunities in the DoD

DTIC Science & Technology

2008-01-01

to the DoD is below the small-business share of all industry sales. In some industries , including aircraft manufacturing and engineer - ing services...for goods not included in the Aircraft Manufacturing category as well as those not in another industry category for aircraft engine and engine parts...Purchases, % Small-Business Share of Industry , %, 20022007 2002 Aircraft Manufacturing 2.3 1.8 8.7 Engineering Services 13.6 16.9 20.3 R&D in the

Industrial Education. "Small Engines".

ERIC Educational Resources Information Center

Parma City School District, OH.

Part of a series of curriculum guides dealing with industrial education in junior high schools, this guide provides the student with information and manipulative experiences on small gasoline engines. Included are sections on shop adjustment, safety, small engines, internal combustion, engine construction, four stroke engines, two stroke engines,…

75 FR 53846 - Airworthiness Directives; Thielert Aircraft Engines GmbH (TAE) Models TAE 125-01 and TAE 125-02...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-02

... Engines Installed In, But Not Limited To, Diamond Aircraft Industries Model DA 42 Airplanes; Correction..., Diamond Aircraft Industries model DA 42 airplanes. The part number for engine model TAE 125-01 is missing...-99 reciprocating engines, installed in, but not limited to, Diamond Aircraft Industries model DA 42...

Industry interests in gambling research: Lessons learned from other forms of hazardous consumption.

PubMed

Cowlishaw, S; Thomas, S L

2018-03-01

Research indicates that the evidential bases for many harm reduction policies targeting hazardous consumptions (including tobacco, alcohol and gambling) have been distorted by commercial industries that derive revenue from such commodities. These distortions are best illustrated by research on tobacco and alcohol, which indicates similar tactics used by industries to determine favourable policy environments through engineering of evidence, among other approaches. Although there is concern that gambling research is similarly vulnerable to commercial interests, the relevant literature lags far behind other fields and the aim of this paper is to increase familiarity with tactics used by industries for influencing research. It summarises the conceptual and empirical bases for expecting conflicts between goals of public health and companies that profit from hazardous consumptions. It also summarises evidence describing practices deployed by tobacco corporations, which include third-party techniques and the selective funding of research to manufacture doubt and deflect attention away from the consequences of smoking. It then reviews both early and emerging evidence indicating similar strategies used by alcohol industry, and uses this literature to view practices of the gambling industry. It argues that parallels regarding selective funding of research and third-party techniques provide grounds for strong concern about commercial influences on gambling research, and implementation of precautionary approaches to management of vested interests. Copyright © 2017 Elsevier Ltd. All rights reserved.

Industrial applications of shearography for inspection of aircraft components

NASA Astrophysics Data System (ADS)

Krupka, Rene; Walz, Thomas; Ettemeyer, Andreas

2005-04-01

Shearography has been validated as fast and reliable inspection technique for aerospace components. Following several years phase of evaluation of the technique, meanwhile, shearography has entered the industrial production inspection. The applications basically range from serial inspection in the production line to field inspection in assembly and to applications in the maintenance and repair area. In all applications, the main advantages of shearography, as very fast and full field insection and high sensitivity even on very complex on composite materials have led to the decision for laser shearography as inspection tool. In this paper, we present some highlights of industrial shearography inspection. One of the first industrial installations of laser shearography in Europe was a fully automatic inspection system for helicopter rotorblades. Complete rotor blades are inspected within 10 minutes on delaminations and debondingg in the composite structure. In case of more complex components, robotic manipulation of the shearography camera has proven to be the optimal solution. An industry 6-axis robot give utmost flexibility to position the camera in any angle and distance. Automatic defect marking systems have also been introduced to indicate the exact position of the defect directly on the inspected component. Other applications are shearography inspection systems for abradable seals in jet engines and portable shearography inspection systems for maintenance and repair inspection in the field. In this paper, recent installations of automatice inspection systems in aerospace industries are presented.

Molecular engineering of industrial enzymes: recent advances and future prospects.

PubMed

Yang, Haiquan; Li, Jianghua; Shin, Hyun-Dong; Du, Guocheng; Liu, Long; Chen, Jian

2014-01-01

Many enzymes are efficiently produced by microbes. However, the use of natural enzymes as biocatalysts has limitations such as low catalytic efficiency, low activity, and low stability, especially under industrial conditions. Many protein engineering technologies have been developed to modify natural enzymes and eliminate these limitations. Commonly used protein engineering strategies include directed evolution, site-directed mutagenesis, truncation, and terminal fusion. This review summarizes recent advances in the molecular engineering of industrial enzymes and discusses future prospects in this field. We expect this review to increase interest in and advance the molecular engineering of industrial enzymes.

Optimal Tuner Selection for Kalman-Filter-Based Aircraft Engine Performance Estimation

NASA Technical Reports Server (NTRS)

Simon, Donald L.; Garg, Sanjay

2011-01-01

An emerging approach in the field of aircraft engine controls and system health management is the inclusion of real-time, onboard models for the inflight estimation of engine performance variations. This technology, typically based on Kalman-filter concepts, enables the estimation of unmeasured engine performance parameters that can be directly utilized by controls, prognostics, and health-management applications. A challenge that complicates this practice is the fact that an aircraft engine s performance is affected by its level of degradation, generally described in terms of unmeasurable health parameters such as efficiencies and flow capacities related to each major engine module. Through Kalman-filter-based estimation techniques, the level of engine performance degradation can be estimated, given that there are at least as many sensors as health parameters to be estimated. However, in an aircraft engine, the number of sensors available is typically less than the number of health parameters, presenting an under-determined estimation problem. A common approach to address this shortcoming is to estimate a subset of the health parameters, referred to as model tuning parameters. The problem/objective is to optimally select the model tuning parameters to minimize Kalman-filterbased estimation error. A tuner selection technique has been developed that specifically addresses the under-determined estimation problem, where there are more unknown parameters than available sensor measurements. A systematic approach is applied to produce a model tuning parameter vector of appropriate dimension to enable estimation by a Kalman filter, while minimizing the estimation error in the parameters of interest. Tuning parameter selection is performed using a multi-variable iterative search routine that seeks to minimize the theoretical mean-squared estimation error of the Kalman filter. This approach can significantly reduce the error in onboard aircraft engine parameter estimation applications such as model-based diagnostic, controls, and life usage calculations. The advantage of the innovation is the significant reduction in estimation errors that it can provide relative to the conventional approach of selecting a subset of health parameters to serve as the model tuning parameter vector. Because this technique needs only to be performed during the system design process, it places no additional computation burden on the onboard Kalman filter implementation. The technique has been developed for aircraft engine onboard estimation applications, as this application typically presents an under-determined estimation problem. However, this generic technique could be applied to other industries using gas turbine engine technology.

The role of gender on academic performance in STEM-related disciplines: Data from a tertiary institution.

PubMed

John, Temitope M; Badejo, Joke A; Popoola, Segun I; Omole, David O; Odukoya, Jonathan A; Ajayi, Priscilla O; Aboyade, Mary; Atayero, Aderemi A

2018-06-01

This data article presents data of academic performances of undergraduate students in Science, Technology, Engineering and Mathematics (STEM) disciplines in Covenant University, Nigeria. The data shows academic performances of Male and Female students who graduated from 2010 to 2014. The total population of samples in the observation is 3046 undergraduates mined from Biochemistry (BCH), Building technology (BLD), Computer Engineering (CEN), Chemical Engineering (CHE), Industrial Chemistry (CHM), Computer Science (CIS), Civil Engineering (CVE), Electrical and Electronics Engineering (EEE), Information and Communication Engineering (ICE), Mathematics (MAT), Microbiology (MCB), Mechanical Engineering (MCE), Management and Information System (MIS), Petroleum Engineering (PET), Industrial Physics-Electronics and IT Applications (PHYE), Industrial Physics-Applied Geophysics (PHYG) and Industrial Physics-Renewable Energy (PHYR). The detailed dataset is made available in form of a Microsoft Excel spreadsheet in the supplementary material of this article.

Renovation of a Mechanical Engineering Senior Design Class to an Industry-Tied and Team-Oriented Course

ERIC Educational Resources Information Center

Liu, Yucheng

2017-01-01

In this work, an industry-based and team-oriented education model was established based on a traditional mechanical engineering (ME) senior design class in order to better prepare future engineers and leaders so as to meet the increasing demand for high-quality engineering graduates. In the renovated curriculum, industry-sponsored projects became…

15 CFR 801.10 - Rules and regulations for the BE-120, Benchmark Survey of Transactions in Selected Services and...

Code of Federal Regulations, 2012 CFR

2012-01-01

... engineering services; industrial-type maintenance, installation, alteration, and training services; legal... services; (17) Financial services (purchases only); (18) Industrial engineering services; (19) Industrial...; educational and training services; engineering, architectural, and surveying services; financial services...

Job Prospects for Computer Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1988-01-01

Discusses the computer engineering industry in the United States. Recounts recent shifts in the computer industry and notes that despite foreign competition, the industry offers graduating computer engineers ample opportunities for employment. Claims that skill and technical knowledge are the most important assets for getting a job. (TW)

Methods of applied dynamics

NASA Technical Reports Server (NTRS)

Rheinfurth, M. H.; Wilson, H. B.

1991-01-01

The monograph was prepared to give the practicing engineer a clear understanding of dynamics with special consideration given to the dynamic analysis of aerospace systems. It is conceived to be both a desk-top reference and a refresher for aerospace engineers in government and industry. It could also be used as a supplement to standard texts for in-house training courses on the subject. Beginning with the basic concepts of kinematics and dynamics, the discussion proceeds to treat the dynamics of a system of particles. Both classical and modern formulations of the Lagrange equations, including constraints, are discussed and applied to the dynamic modeling of aerospace structures using the modal synthesis technique.

Engineering Technology Education: Bibliography 1989.

ERIC Educational Resources Information Center

Dyrud, Marilyn A., Comp.

1990-01-01

Over 200 references divided into 24 different areas are presented. Topics include administration, aeronautics, architecture, biomedical technology, CAD/CAM, civil engineering, computers, curriculum, electrical/electronics engineering, industrial engineering, industry and employment, instructional technology, laboratories, lasers, liberal studies,…

Industrial brewing yeast engineered for the production of primary flavor determinants in hopped beer.

PubMed

Denby, Charles M; Li, Rachel A; Vu, Van T; Costello, Zak; Lin, Weiyin; Chan, Leanne Jade G; Williams, Joseph; Donaldson, Bryan; Bamforth, Charles W; Petzold, Christopher J; Scheller, Henrik V; Martin, Hector Garcia; Keasling, Jay D

2018-03-20

Flowers of the hop plant provide both bitterness and "hoppy" flavor to beer. Hops are, however, both a water and energy intensive crop and vary considerably in essential oil content, making it challenging to achieve a consistent hoppy taste in beer. Here, we report that brewer's yeast can be engineered to biosynthesize aromatic monoterpene molecules that impart hoppy flavor to beer by incorporating recombinant DNA derived from yeast, mint, and basil. Whereas metabolic engineering of biosynthetic pathways is commonly enlisted to maximize product titers, tuning expression of pathway enzymes to affect target production levels of multiple commercially important metabolites without major collateral metabolic changes represents a unique challenge. By applying state-of-the-art engineering techniques and a framework to guide iterative improvement, strains are generated with target performance characteristics. Beers produced using these strains are perceived as hoppier than traditionally hopped beers by a sensory panel in a double-blind tasting.

Interface Engineering for Nanoelectronics.

PubMed

Hacker, C A; Bruce, R C; Pookpanratana, S J

2017-01-01

Innovation in the electronics industry is tied to interface engineering as devices increasingly incorporate new materials and shrink. Molecular layers offer a versatile means of tuning interfacial electronic, chemical, physical, and magnetic properties enabled by a wide variety of molecules available. This paper will describe three instances where we manipulate molecular interfaces with a specific focus on the nanometer scale characterization and the impact on the resulting performance. The three primary themes include, 1-designer interfaces, 2-electronic junction formation, and 3-advancing metrology for nanoelectronics. We show the ability to engineer interfaces through a variety of techniques and demonstrate the impact on technologies such as molecular memory and spin injection for organic electronics. Underpinning the successful modification of interfaces is the ability to accurately characterize the chemical and electronic properties and we will highlight some measurement advances key to our understanding of the interface engineering for nanoelectronics.

Interface Engineering for Nanoelectronics

PubMed Central

Hacker, C. A.; Bruce, R. C.; Pookpanratana, S. J.

2017-01-01

Innovation in the electronics industry is tied to interface engineering as devices increasingly incorporate new materials and shrink. Molecular layers offer a versatile means of tuning interfacial electronic, chemical, physical, and magnetic properties enabled by a wide variety of molecules available. This paper will describe three instances where we manipulate molecular interfaces with a specific focus on the nanometer scale characterization and the impact on the resulting performance. The three primary themes include, 1-designer interfaces, 2-electronic junction formation, and 3-advancing metrology for nanoelectronics. We show the ability to engineer interfaces through a variety of techniques and demonstrate the impact on technologies such as molecular memory and spin injection for organic electronics. Underpinning the successful modification of interfaces is the ability to accurately characterize the chemical and electronic properties and we will highlight some measurement advances key to our understanding of the interface engineering for nanoelectronics. PMID:29276553

A first step toward understanding patient safety

PubMed Central

2016-01-01

Patient safety has become an important policy agenda in healthcare systems since publication of the 1999 report entitled "To Err Is Human." The paradigm has changed from blaming the individual for the error to identifying the weakness in the system that led to the adverse events. Anesthesia is one of the first healthcare specialties to adopt techniques and lessons from the aviation industry. The widespread use of simulation programs and the application of human factors engineering to clinical practice are the influences of the aviation industry. Despite holding relatively advanced medical technology and comparable safety records, the Korean health industry has little understanding of the systems approach to patient safety. Because implementation of the existing system and program requires time, dedication, and financial support, the Korean healthcare industry is in urgent need of developing patient safety policies and putting them into practice to improve patient safety before it is too late. PMID:27703622

Vibro-acoustic condition monitoring of Internal Combustion Engines: A critical review of existing techniques

NASA Astrophysics Data System (ADS)

Delvecchio, S.; Bonfiglio, P.; Pompoli, F.

2018-01-01

This paper deals with the state-of-the-art strategies and techniques based on vibro-acoustic signals that can monitor and diagnose malfunctions in Internal Combustion Engines (ICEs) under both test bench and vehicle operating conditions. Over recent years, several authors have summarized what is known in critical reviews mainly focused on reciprocating machines in general or on specific signal processing techniques: no attempts to deal with IC engine condition monitoring have been made. This paper first gives a brief summary of the generation of sound and vibration in ICEs in order to place further discussion on fault vibro-acoustic diagnosis in context. An overview of the monitoring and diagnostic techniques described in literature using both vibration and acoustic signals is also provided. Different faulty conditions are described which affect combustion, mechanics and the aerodynamics of ICEs. The importance of measuring acoustic signals, as opposed to vibration signals, is due since the former seem to be more suitable for implementation on on-board monitoring systems in view of their non-intrusive behaviour, capability in simultaneously capturing signatures from several mechanical components and because of the possibility of detecting faults affecting airborne transmission paths. In view of the recent needs of the industry to (-) optimize component structural durability adopting long-life cycles, (-) verify the engine final status at the end of the assembly line and (-) reduce the maintenance costs monitoring the ICE life during vehicle operations, monitoring and diagnosing system requests are continuously growing up. The present review can be considered a useful guideline for test engineers in understanding which types of fault can be diagnosed by using vibro-acoustic signals in sufficient time in both test bench and operating conditions and which transducer and signal processing technique (of which the essential background theory is here reported) could be considered the most reliable and informative to be implemented for the fault in question.

Applications guide for waste heat recovery

NASA Technical Reports Server (NTRS)

Moynihan, P. I.

1983-01-01

The state-of-the-art of commercially available organic Rankine cycle (ORC) hardware from a literature search and industry survey is assessed. Engineering criteria for applying ORC technology are established, and a set of nomograms to enable the rapid sizing of the equipment is presented. A comparison of an ORC system with conventional heat recovery techniques can be made with a nomogram developed for a recuperative heat exchanger. A graphical technique for evaluating the economic aspects of an ORC system and conventional heat recovery method is discussed: also included is a description of anticipated future trends in organic Rankine cycle R&D.

Compressed air production with waste heat utilization in industry

NASA Astrophysics Data System (ADS)

Nolting, E.

1984-06-01

The centralized power-heat coupling (PHC) technique using block heating power stations, is presented. Compressed air production in PHC technique with internal combustion engine drive achieves a high degree of primary energy utilization. Cost savings of 50% are reached compared to conventional production. The simultaneous utilization of compressed air and heat is especially interesting. A speed regulated drive via an internal combustion motor gives a further saving of 10% to 20% compared to intermittent operation. The high fuel utilization efficiency ( 80%) leads to a pay off after two years for operation times of 3000 hr.

Bioethanol production from tuber crops using fermentation technology: a review

NASA Astrophysics Data System (ADS)

Thatoi, Hrudayanath; Dash, Preeti Krishna; Mohapatra, Sonali; Swain, Manas Ranjan

2016-05-01

Bioethanol, an alcohol produced by fermentation of plant biomass containing starch and sugars by micro-organisms, considered as a dominant form of fuel for future. Production of this renewable fuel, especially from starchy materials such as tuber crops, holds a remarkable potential to meet the future energy demand because of its high production and comparitively less demand for use as food and fodder. This review focuses on the world bioethanol production scenario from various tuber crops, namely cassava, sweet potato, potato, yam, aroids, sugar beet, etc., fermentation techniques and micro-organisms used in fermentation process along with its future prospects. The advances in metabolic pathway engineering and genetic engineering techniques have led to the development of micro-organisms capable of efficiently converting biomass sugars into ethanol. Several biotechnological tools that are also available for the improvement of microorganisms to meet the harsh environments typically met with certain industrial fermentation process are also discussed.

Job Prospects for Industrial Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1986-01-01

Because of the impetus on how to improve productivity in companies, the demand for graduating industrial engineers continues to be strong from a variety of sources. Starting salary offers for graduates have been averaging $26,784. Enrollments in industrial engineering programs are increasing (with 3,923 graduates in 1984). (JN)

Magnetic Resonance Imaging and Velocity Mapping in Chemical Engineering Applications.

PubMed

Gladden, Lynn F; Sederman, Andrew J

2017-06-07

This review aims to illustrate the diversity of measurements that can be made using magnetic resonance techniques, which have the potential to provide insights into chemical engineering systems that cannot readily be achieved using any other method. Perhaps the most notable advantage in using magnetic resonance methods is that both chemistry and transport can be followed in three dimensions, in optically opaque systems, and without the need for tracers to be introduced into the system. Here we focus on hydrodynamics and, in particular, applications to rheology, pipe flow, and fixed-bed and gas-solid fluidized bed reactors. With increasing development of industrially relevant sample environments and undersampling data acquisition strategies that can reduce acquisition times to <1 s, magnetic resonance is finding increasing application in chemical engineering research.

Industrial metrology as applied to large physics experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Veal, D.

1993-05-01

A physics experiment is a large complex 3-D object (typ. 1200 m{sup 3}, 35000 tonnes), with sub-millimetric alignment requirements. Two generic survey alignment tasks can be identified; first, an iterative positioning of the apparatus subsystems in space and, second, a quantification of as-built parameters. The most convenient measurement technique is industrial triangulation but the complexity of the measured object and measurement environment constraints frequently requires a more sophisticated approach. To enlarge the ``survey alignment toolbox`` measurement techniques commonly associated with other disciplines such as geodesy, applied geodesy for accelerator alignment, and mechanical engineering are also used. Disparate observables require amore » heavy reliance on least squares programs for campaign pre-analysis and calculation. This paper will offer an introduction to the alignment of physics experiments and will identify trends for the next generation of SSC experiments.« less

Development of volume deposition on cast iron by additive manufacturing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sridharan, Niyanth; Dehoff, Ryan R.; Jordan, Brian H.

2016-11-10

ORNL partnered with Cummins to demonstrate the feasibility of using additive manufacturing techniques to help develop repair techniques for refurbished cast iron engine blocks. Cummins is interested in the refurbished engine business due to the increased cost savings and reduced emissions. It is expected that by refurbishing engines could help reduce the green house gas emissions by as much as 85%. Though such repair techniques are possible in principle there has been no major industry in the automotive sector that has deployed this technology. Therefore phase-1 would seek to evaluate the feasibility of using the laser directed energy deposition techniquemore » to repair cast iron engine blocks. The objective of the phase-1 would be to explore various strategies and understand the challenges involved. During phase-1 deposits were made using Inconel-718, Nickel, Nr-Cr-B braze filler. Inconel 718 builds showed significant cracking in the heat-affected zone in the cast iron. Nickel was used to reduce the cracking in the cast iron substrate, however the Ni builds did not wet the substrate sufficiently resulting in poor dimensional tolerance. In order to increase wetting the Ni was alloyed with the Ni-Cr-B braze to decrease the surface tension of Ni. This however resulted in significant cracks in the build due to shrinkage stresses associated with multiple thermal cycling. Hence to reduce the residual stresses in the builds the DMD-103D equipment was modified and the cast iron block was pre heated using cartridge heaters. Inconel-718 alloyed with Ni was deposited on the engine block. The pre-heated deposits showed a reduced susceptibility to cracking. If awarded the phase-2 of the project would aim to develop process parameters to achieve a crack free deposit engine block.« less

Design Engineering of Biomaterials for Medical Devices

NASA Astrophysics Data System (ADS)

Hill, David

1998-10-01

Written by an exceptionally experienced author in the area of medical equipment product design, this text presents a comprehensive overview of such sound principles and state-of-the-art techniques covering a whole host of material types, biocompatability, the design process and future trends within this exciting field. An all-in-one reference text, concise and easy-to-read. Wide audience appeal, from industry professionals to students of design.

CORDETS ( Component Oriented Development Techniques) and DOMENG (Domain Engineering)

NASA Astrophysics Data System (ADS)

Rodríquez-Dapena, P.

2008-08-01

This document presents the results of Workshop 2 held on the 28th of May 2008 in Palma de Mallorca as part of the DASIA2008 conference. The workshop is used for the setup and animation of the stakeholders' network intended to bring together the actors in the field of the future generic space on-board software architectures, in order to get a common vision, technical understanding and industrial interests.

Manufacturing Methods and Technology Program Plan. Update.

DTIC Science & Technology

1981-11-01

INDUSTRIAL BASE ENGINEERING ACTIVITY ROCK ISLAND. ILLINOIS 61299 82 INDEX PAGE I. INTRODUCTION The MMT Program Plan Update ........... 1 Industry Guide...obtained from that Plan, extra copies of which are available upon request from the Industrial Base Engineering Activity. Other sources for this data are...Major Subcommands (SUBMACOM’S). The SUBMACOM’S plan, formulate, budget, and execute individual projects. The Industrial Base Engineering Activity

Advanced Light-Duty SI Engine Fuels Research: Multiple Optical Diagnostics of Well-mixed and Stratified Operation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjoberg, Carl Magnus Goran; Vuilleumier, David

Ever tighter fuel economy standards and concerns about energy security motivate efforts to improve engine efficiency and to develop alternative fuels. This project contributes to the science base needed by industry to develop highly efficient direct injection spark ignition (DISI) engines that also beneficially exploit the different properties of alternative fuels. Here, the emphasis is on lean operation, which can provide higher efficiencies than traditional non-dilute stoichiometric operation. Since lean operation can lead to issues with ignition stability, slow flame propagation and low combustion efficiency, the focus is on techniques that can overcome these challenges. Specifically, fuel stratification is usedmore » to ensure ignition and completeness of combustion but this technique has soot and NOx emissions challenges. For ultra-lean well-mixed operation, turbulent deflagration can be combined with controlled end-gas autoignition to render mixed-mode combustion for sufficiently fast heat release. However, such mixed-mode combustion requires very stable inflammation, motivating studies on the effects of near-spark flow and turbulence, and the use of small amounts of fuel stratification near the spark plug.« less

Thermal Characterization, Using the Photopyroelectric Technique, of Liquids Used in the Automobile Industry

NASA Astrophysics Data System (ADS)

Cervantes-Espinosa, L. M.; Castillo-Alvarado, F. de L.; Lara-Hernández, G.; Cruz-Orea, A.; Mendoza-Alvarez, J. G.; Valcárcel, J. P.; García-Quiroz, A.

2012-11-01

Thermal properties of liquids used in the automobile industry such as engine oil, antifreeze, and a liquid for windshield wipers were obtained using the photopyroelectric (PPE) technique. The inverse PPE configuration was used in order to obtain the thermal effusivity of the liquid samples. The theoretical equation for the PPE signal in this configuration, as a function of the incident light modulation frequency, was fitted to the experimental data in order to obtain the thermal effusivity of these samples. Also, the back PPE configuration was used to obtain the thermal diffusivity of these liquids; this thermal parameter was obtained by fitting the theoretical equation for this configuration, as a function of the sample thickness (called the thermal wave resonator cavity), to the experimental data. All measurements were done at room temperature. A complete thermal characterization of these liquids used in the automobile industry was achieved by the relationship between the obtained thermal diffusivities and thermal effusivities with their thermal conductivities and volumetric heat capacities. The obtained results are compared with the thermal properties of similar liquids.

Training Engineers of Joint Programs for the European Aerospace Industry.

ERIC Educational Resources Information Center

Thomas, Jurgen

1985-01-01

Examines topics and issues related to training engineers of joint programs for the European aerospace industry. Forms of cooperation, European educational systems, and skills needed to successfully work as an engineer in a joint program for the European aircraft industry are the major areas addressed. (JN)

An Industrial Engineering Approach to Cost Containment of Pharmacy Education.

PubMed

Duncan, Wendy; Bottenberg, Michelle; Chase, Marilea; Chesnut, Renae; Clarke, Cheryl; Schott, Kathryn; Torry, Ronald; Welty, Tim

2015-11-25

A 2-semester project explored employing teams of fourth-year industrial engineering students to optimize some of our academic management processes. Results included significant cost savings and increases in efficiency, effectiveness, and student and faculty satisfaction. While we did not adopt all of the students' recommendations, we did learn some important lessons. For example, an initial investment of time in developing a mutually clear understanding of the problems, constraints, and goals maximizes the value of industrial engineering analysis and recommendations. Overall, industrial engineering was a valuable tool for optimizing certain academic management processes.

Perspective on thermal barrier coatings for industrial gas turbine applications

NASA Technical Reports Server (NTRS)

Mutasim, Z. Z.; Hsu, L. L.; Brentnall, W. D.

1995-01-01

Thermal Barrier Coatings (TBC's) have been used in high thrust aircraft engines for many years, and have proved to be very effective in allowing higher turbine inlet temperatures. TBC life requirements for aircraft engines are typically less than those required in industrial gas turbines. The use of TBC's for industrial gas turbines can increase if durability and longer service life can be successfully demonstrated. This paper will describe current and future applications of TBC's in industrial gas turbine engines. Early testing and applications of TBC's will also be reviewed. This paper focuses on the key factors that are expected to influence utilization of TBC's in advanced industrial gas turbine engines. It is anticipated that reliable, durable and high effective coating systems will be produced that will ultimately improve engine efficiency and performance.

3D Printing Optical Engine for Controlling Material Microstructure

NASA Astrophysics Data System (ADS)

Huang, Wei-Chin; Chang, Kuang-Po; Wu, Ping-Han; Wu, Chih-Hsien; Lin, Ching-Chih; Chuang, Chuan-Sheng; Lin, De-Yau; Liu, Sung-Ho; Horng, Ji-Bin; Tsau, Fang-Hei

Controlling the cooling rate of alloy during melting and resolidification is the most commonly used method for varying the material microstructure and consequently the resuling property. However, the cooling rate of a selective laser melting (SLM) production is restricted by a preset optimal parameter of a good dense product. The head room for locally manipulating material property in a process is marginal. In this study, we invent an Optical Engine for locally controlling material microstructure in a SLM process. It develops an invovative method to control and adjust thermal history of the solidification process to gain desired material microstucture and consequently drastically improving the quality. Process parameters selected locally for specific materials requirement according to designed characteristics by using thermal dynamic principles of solidification process. It utilize a technique of complex laser beam shape of adaptive irradiation profile to permit local control of material characteristics as desired. This technology could be useful for industrial application of medical implant, aerospace and automobile industries.

PREFACE: Trends in Aerospace Manufacturing 2009 International Conference

NASA Astrophysics Data System (ADS)

Ridgway, Keith; Gault, Rosemary; Allen, Adrian

2011-12-01

The aerospace industry is rapidly changing. New aircraft structures are being developed and aero-engines are becoming lighter and more environmentally friendly. In both areas, innovative materials and manufacturing methods are used in an attempt to get maximum performance for minimum cost. At the same time, the structure of the industry has changed and there has been a move from large companies designing, manufacturing components and assembling aircraft to one of large global supply chains headed by large system integrators. All these changes have forced engineers and managers to bring in innovations in design, materials, manufacturing technologies and supply chain management. In September 2009, the Advanced Manufacturing Research Centre (AMRC) at the University of Sheffield held the inaugural Trends in Aerospace Manufacturing conference (TRAM09). This brought together 28 speakers over two days, who presented in sessions on advanced manufacturing trends for the aerospace sector. Areas covered included new materials, including composites, advanced machining, state of the art additive manufacturing techniques, assembly and supply chain issues.

Chemical Engineering in Education and Industry.

ERIC Educational Resources Information Center

Wei, James

1986-01-01

Provides an historical overview of the origins, developments, and contributions of chemical engineering. Reviews the roles of the university and industry in the education of chemical engineers. Includes a listing of the major advances of chemical engineering since World War II. (ML)

Engineering thermoplastics for additive manufacturing: a critical perspective with experimental evidence to support functional applications.

PubMed

Cicala, Gianluca; Latteri, Alberta; Del Curto, Barbara; Lo Russo, Alessio; Recca, Giuseppe; Farè, Silvia

2017-01-28

Among additive manufacturing techniques, the filament-based technique involves what is referred to as fused deposition modeling (FDM). FDM materials are currently limited to a selected number of polymers. The present study focused on investigating the potential of using high-end engineering polymers in FDM. In addition, a critical review of the materials available on the market compared with those studied here was completed. Different engineering thermoplastics, ranging from industrial grade polycarbonates to novel polyetheretherketones (PEEKs), were processed by FDM. Prior to this, for innovative filaments based on PEEK, extrusion processing was carried out. Mechanical properties (i.e., tensile and flexural) were investigated for each extruded material. An industrial-type FDM machine (Stratasys Fortus® 400 mc) was used to fully characterize the effect of printing parameters on the mechanical properties of polycarbonate. The obtained properties were compared with samples obtained by injection molding. Finally, FDM samples made of PEEK were also characterized and compared with those obtained by injection molding. The effect of raster to raster air gap and raster angle on tensile and flexural properties of printed PC was evidenced; the potential of PEEK filaments, as novel FDM material, was highlighted in comparison to state of the art materials. Comparison with injection molded parts allowed to better understand FDM potential for functional applications. The study discussed pros and cons of the different materials. Finally, the development of novel PEEK filaments achieved important results offering a novel solution to the market when high mechanical and thermal properties are required.

The Future for Industrial Engineers: Education and Research Opportunities

ERIC Educational Resources Information Center

Mummolo, Giovanni

2007-01-01

EU graduation and the recruitment of industrial engineers (IEs) have been investigated. An increasing demand is observed for graduates in almost all industrial engineering (IE) subjects. The labour market in the EU is evolving towards the service sector even if manufacturing still represents a significant share of both IE employment and gross…

Enhancing the Undergraduate Industrial Engineering Curriculum: Defining Desired Characteristics and Emerging Topics

ERIC Educational Resources Information Center

Eskandari, Hamidreza; Sala-Diakanda, Serge; Furterer, Sandra; Rabelo, Luis; Crumpton-Young, Lesia; Williams, Kent

2007-01-01

Purpose: This paper aims to present the results of an initial research study conducted to identify the desired professional characteristics of an industrial engineer with an undergraduate degree and the emerging topic areas that should be incorporated into the curriculum to prepare industrial engineering (IE) graduates for the future workforce.…

Flow in porous media, phase behavior and ultralow interfacial tensions: mechanisms of enhanced petroleum recovery. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, H.T.; Scriven, L.E.

1982-01-01

A major program of university research, longer-ranged and more fundamental in approach than industrial research, into basic mechanisms of enhancing petroleum recovery and into underlying physics, chemistry, geology, applied mathematics, computation, and engineering science has been built at Minnesota. The 1982 outputs of the interdisciplinary team of investigators were again ideas, instruments, techniques, data, understanding and skilled people: forty-one scientific and engineering papers in leading journals; four pioneering Ph.D. theses; numerous presentations to scientific and technical meetings, and to industrial, governmental and university laboratories; vigorous program of research visits to and from Minnesota; and two outstanding Ph.D.'s to research positionsmore » in the petroleum industry, one to a university faculty position, one to research leadership in a governmental institute. This report summarizes the 1982 papers and theses and features sixteen major accomplishments of the program during that year. Abstracts of all forty-five publications in the permanent literature are appended. Further details of information transfer and personnel exchange with industrial, governmental and university laboratories appear in 1982 Quarterly Reports available from the Department of Energy and are not reproduced here. The Minnesota program continues in 1983, notwithstanding earlier uncertainty about the DOE funding which finally materialized and is the bulk of support. Supplemental grants-in-aid from nine companies in the petroleum industry are important, as are the limited University and departmental contributions. 839 references, 172 figures, 29 tables.« less

Genetic engineering of industrial strains of Saccharomyces cerevisiae.

PubMed

Le Borgne, Sylvie

2012-01-01

Genetic engineering has been successfully applied to Saccharomyces cerevisiae laboratory strains for different purposes: extension of substrate range, improvement of productivity and yield, elimination of by-products, improvement of process performance and cellular properties, and extension of product range. The potential of genetically engineered yeasts for the massive production of biofuels as bioethanol and other nonfuel products from renewable resources as lignocellulosic biomass hydrolysates has been recognized. For such applications, robust industrial strains of S. cerevisiae have to be used. Here, some relevant genetic and genomic characteristics of industrial strains are discussed in relation to the problematic of the genetic engineering of such strains. General molecular tools applicable to the manipulation of S. cerevisiae industrial strains are presented and examples of genetically engineered industrial strains developed for the production of bioethanol from lignocellulosic biomass are given.

A Multidisciplinary Engineering Summer School in an Industrial Setting

ERIC Educational Resources Information Center

Larsen, Peter Gorm; Fernandes, Joao M.; Habel, Jacek; Lehrskov, Hanne; Vos, Richard J. C.; Wallington, Oliver; Zidek, Jan

2009-01-01

Most university-level engineering studies produce technically skilled engineers. However, typically students face several difficulties when working in multidisciplinary teams when they initiate their industrial careers. In a globalised world, it becomes increasingly important that engineers are capable of collaborating across disciplinary…

An Industrial Engineering Approach to Cost Containment of Pharmacy Education

PubMed Central

Bottenberg, Michelle; Chase, Marilea; Chesnut, Renae; Clarke, Cheryl; Schott, Kathryn; Torry, Ronald; Welty, Tim

2015-01-01

A 2-semester project explored employing teams of fourth-year industrial engineering students to optimize some of our academic management processes. Results included significant cost savings and increases in efficiency, effectiveness, and student and faculty satisfaction. While we did not adopt all of the students’ recommendations, we did learn some important lessons. For example, an initial investment of time in developing a mutually clear understanding of the problems, constraints, and goals maximizes the value of industrial engineering analysis and recommendations. Overall, industrial engineering was a valuable tool for optimizing certain academic management processes. PMID:26839421

Developing a New Industrial Engineering Curriculum Using a Systems Engineering Approach

ERIC Educational Resources Information Center

Buyurgan, Nebil; Kiassat, Corey

2017-01-01

This paper reports on the development of an engineering curriculum for a new industrial engineering programme at a medium-sized private university in the northeast United States. A systems engineering process has been followed to design and develop the new curriculum. Considering the programme curriculum as a system, first the stakeholders have…

Industrial applications of shearography for inspections of aircraft components

NASA Astrophysics Data System (ADS)

Krupka, Rene; Waltz, T.; Ettemeyer, Andreas

2003-05-01

Shearography has been validated as fast and reliable inspection technique for aerospace components. Following several years phase of evaluation of the technique, meanwhile, shearography has entered the industrial production inspection. The applications basically range from serial inspection in the production line to field inspection in assembly and to applications in the maintenance and repair area. In all applications, the main advantages of shearography, as very fast and full field inspection and high sensitivity even on very complex composite materials have led to the decision for laser shearography as inspection tool. In this paper, we present examples of recent industrial shearography inspection systems in the field of aerospace. One of the first industrial installations of laser shearography in Europe was a fully automatic inspection system for helicopter rotorblades. Complete rotor blades are inspected within 10 minutes on delaminations and debondings in the composite structure. In case of more complex components, robotic manipulation of the shearography camera has proven to be the optimum solution. An industry 6-axis robot gives utmost flexibility to position the camera in any angle and distance. Automatic defect marking systems have also been introduced to indicate the exact position of the defect directly on the inspected component. Other applications cover the inspection of abradable seals in jet engines and portable shearography inspection systems for maintenance and repair inspection in the field.

Micro to Nanoscale Engineering of Surface Precipitates Using Reconfigurable Contact Lines.

PubMed

Kabi, Prasenjit; Chaudhuri, Swetaprovo; Basu, Saptarshi

2018-02-06

Nanoscale engineering has traditionally adopted the chemical route of synthesis or optochemical techniques such as lithography requiring large process times, expensive equipment, and an inert environment. Directed self-assembly using evaporation of nanocolloidal droplet can be a potential low-cost alternative across various industries ranging from semiconductors to biomedical systems. It is relatively simple to scale and reorient the evaporation-driven internal flow field in an evaporating droplet which can direct dispersed matter into functional agglomerates. The resulting functional precipitates not only exhibit macroscopically discernible changes but also nanoscopic variations in the particulate assembly. Thus, the evaporating droplet forms an autonomous system for nanoscale engineering without the need for external resources. In this article, an indigenous technique of interfacial re-engineering, which is both simple and inexpensive to implement, is developed. Such re-engineering widens the horizon for surface patterning previously limited by the fixed nature of the droplet interface. It involves handprinting hydrophobic lines on a hydrophilic substrate to form a confinement of any selected geometry using a simple document stamp. Droplets cast into such confinements get modulated into a variety of shapes. The droplet shapes control the contact line behavior, evaporation dynamics, and complex internal flow pattern. By exploiting the dynamic interplay among these variables, we could control the deposit's macro- as well as nanoscale assembly not possible with simple circular droplets. We provide a detailed mechanism of the coupling at various length scales enabling a predictive capability in custom engineering, particularly useful in nanoscale applications such as photonic crystals.

A review of composite material applications in the automotive industry for the electric and hybrid vehicle

NASA Technical Reports Server (NTRS)

Bauer, J. L.

1979-01-01

A review is made of the state-of-the-art in regard to the use of composite materials for reducing the structural mass of automobiles. Reduction of mass provides, in addition to other engineering improvements, increased performance/range advantages that are particularly needed in the electric and hybrid vehicle field. Problems encountered include the attainment of mass production techniques and the prevention of environmental hazards.

Cumulative Reports and Publications through December 31, 1989 (Institute for Computer Applications in Science and Engineering)

DTIC Science & Technology

1990-05-01

Research is conducted primarily by visiting scientists from universities and industry who have resident appointments for limited periods of time , and...Elsevier Science Publishers B. V. (North-holland), IFIP, 1989. Crowley, Kay, Joel Saltz, Ravi Mirchandaney, and Harry Berryman: Run- time scheduling...Inverse problem techniques for beams with tip body and time hysteresis camping. ICASE Report No. 89-22, April 18, 1989. 24 pages. To appear in

A History of the Development of the Navy Medical Department’s Workload Management System for Nursing.

DTIC Science & Technology

1987-08-01

efficient and rational methodology. Young, Giovannetti, Lewison , and Thomas (1981) offer the following comprehensive definition of a staffing methodology... Johns Hopkins Hospital. Connor used industrial engineering techniques, such as work sampling, time and motion studies, and continuous observation, to time...ADA 109883-ADA 109886). Young, J.P., Giovannetti, P., Lewison , D., & Thomas, M.L. Factors Affecting Nurse Staffing in Acute Care Hospitals: A Review

Elementary and Advanced Computer Projects for the Physics Classroom and Laboratory

DTIC Science & Technology

1992-12-01

are SPF/PC, MS Word, n3, Symphony, Mathematics, and FORTRAN. The authors’ programs assist data analysis in particular laboratory experiments and make...assist data analysis in particular laboratory experiments and make use of the Monte Carlo and other numerical techniques in computer simulation and...the language of science and engineering in industry and government laboratories (alth..4h C is becoming a powerful competitor ). RM/FORTRAN (cost $400

Probabilistic consensus scoring improves tandem mass spectrometry peptide identification.

PubMed

Nahnsen, Sven; Bertsch, Andreas; Rahnenführer, Jörg; Nordheim, Alfred; Kohlbacher, Oliver

2011-08-05

Database search is a standard technique for identifying peptides from their tandem mass spectra. To increase the number of correctly identified peptides, we suggest a probabilistic framework that allows the combination of scores from different search engines into a joint consensus score. Central to the approach is a novel method to estimate scores for peptides not found by an individual search engine. This approach allows the estimation of p-values for each candidate peptide and their combination across all search engines. The consensus approach works better than any single search engine across all different instrument types considered in this study. Improvements vary strongly from platform to platform and from search engine to search engine. Compared to the industry standard MASCOT, our approach can identify up to 60% more peptides. The software for consensus predictions is implemented in C++ as part of OpenMS, a software framework for mass spectrometry. The source code is available in the current development version of OpenMS and can easily be used as a command line application or via a graphical pipeline designer TOPPAS.

Brief overview of the various families of grouts and their aplications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nandts, A.

1989-04-01

It is difficult to maintain an up-to-date overview of all the grouts presently used on the international market. Better grouts are continuously developed and more formulators are making their appearance. Consequently, it is difficult to clearly define all of the products in the industry. This topic has been the subject of numerous papers and textbooks. Most authors, however, only focus on their fields of interest: applications in geotechnical, or rehabilitation, or seepage control in civil engineering, oil or mining industry. There has been a limited transfer of technology from one field to the other because of the enormous differences inmore » magnitude, site conditions and consequently the application techniques. The tools an engineer has are: his expertise in grouting and engineering background, equipment available or to be designed or modified to carry out a particular job, relevant data available from other sciences, and products with a variety of characteristics. This paper concentrates on product selection. The most suitable product for a particular project requires a good understanding of the general chemical and mechanical characteristics of the grout. The grouts have been classified into four categories for the purpose of this paper. There may be other methods of classification; however, this is only an attempt to help the industry with the selection of the most suitable grout for a given application. The four categories are: suspension grouts, chemical grouts, hot melts, and precipitation grouts. 1 fig.« less

A Resident Engineer.

ERIC Educational Resources Information Center

Chapman, Gary T.

This paper examines the work of resident engineers in a university setting. The need for engineers with industrial experience is established, and the benefits of using resident engineers in training programs are cited. Attributes and problems associated with the practice are studied from the viewpoints of industry, government, universities, and…

Competences of Engineers in the Iron and Steel Industry

NASA Astrophysics Data System (ADS)

Kozhevnikov, A. V.

2017-12-01

The article presents the results of assessment of the professional performance of engineers working in the iron and steel industry. A competence-based profile of highly-qualified professionals has been built. The study of the competences of the iron and steel industry engineers has shown that their knowledge and skills may be mobilized to solve professional tasks.

An Empirical Study of Industrial Engineering and Management Curriculum Reform in Fostering Students' Creativity

ERIC Educational Resources Information Center

Chen, Chi-Kuang; Jiang, Bernard C.; Hsu, Kuang-Yiao

2005-01-01

The objective of this paper is to examine the effectiveness of a creativity-fostering program in industrial engineering and management (IE&M) curriculum reform. Fostering creativity in students has become a crucial issue in industrial engineering education. In a survey of previous studies, we found few on IE&M curriculum reform. In…

Precision Joining Center

NASA Astrophysics Data System (ADS)

Powell, J. W.; Westphal, D. A.

1991-08-01

A workshop to obtain input from industry on the establishment of the Precision Joining Center (PJC) was held on July 10-12, 1991. The PJC is a center for training Joining Technologists in advanced joining techniques and concepts in order to promote the competitiveness of U.S. industry. The center will be established as part of the DOE Defense Programs Technology Commercialization Initiative, and operated by EG&G Rocky Flats in cooperation with the American Welding Society and the Colorado School of Mines Center for Welding and Joining Research. The overall objectives of the workshop were to validate the need for a Joining Technologists to fill the gap between the welding operator and the welding engineer, and to assure that the PJC will train individuals to satisfy that need. The consensus of the workshop participants was that the Joining Technologist is a necessary position in industry, and is currently used, with some variation, by many companies. It was agreed that the PJC core curriculum, as presented, would produce a Joining Technologist of value to industries that use precision joining techniques. The advantage of the PJC would be to train the Joining Technologist much more quickly and more completely. The proposed emphasis of the PJC curriculum on equipment intensive and hands-on training was judged to be essential.

Manual for implementing a Shared Time Engineering Program (STEP) September 1980 through September 1983

NASA Astrophysics Data System (ADS)

Aronoff, H. I.; Leslie, J. J.; Mittleman, A. N.; Holt, S.

1983-11-01

This manual describes a Shared Time Engineering Program (STEP) conducted by the New England Apparel Manufacturers Association (NEAMA) headquartered in Fall River Massachusetts, and funded by the Office of Trade Adjustment Assistance of the U.S. Department of Commerce. It is addressed to industry association executives, industrial engineers and others interested in examining an innovative model of industrial engineering assistance to small plants which might be adapted to their particular needs.

Sputtering. [as deposition technique in mechanical engineering

NASA Technical Reports Server (NTRS)

Spalvins, T.

1976-01-01

This paper primarily reviews the potential of using the sputtering process as a deposition technique; however, the manufacturing and sputter etching aspects are also discussed. Since sputtering is not regulated by classical thermodynamics, new multicomponent materials can be developed in any possible chemical composition. The basic mechanism for dc and rf sputtering is described. Sputter-deposition is described in terms of the unique advantageous features it offers such as versatility, momentum transfer, stoichiometry, sputter-etching, target geometry (coating complex surfaces), precise controls, flexibility, ecology, and sputtering rates. Sputtered film characteristics, such as strong adherence and coherence and film morphology, are briefly evaluated in terms of varying the sputtering parameters. Also described are some of the specific industrial areas which are turning to sputter-deposition techniques.

Collaboration between Industrial Designers and Design Engineers - Comparing the Understanding of Design Intent.

PubMed

Laursen, Esben Skov; Møller, Louise

2015-01-01

This paper describes a case study comparing the understanding of design intent between industrial designers and design engineers. The study is based on the hypothesis that it is not all aspects of the design intent that are equally difficult to share between industrial designers and design engineers in the product development process. The study builds on five semi-structured interviews, where two industrial designers and three design engineers were interviewed about different aspects of the design intent. Based on our results, there seem to be indications that the more complex and abstract elements of industrial design knowledge such as the meaning, semantics, values, emotions and social aspects of the product are less shared by the design engineers. Moreover, the results also indicate that the different aspects of the design intent are perceived separately, rather than as part of a whole by the design engineers. The connection between the different aspects of the design intent is not shared between the industrial designer and design engineer making the shared knowledge less meaningful to the design engineers. The results of this study cannot be claimed to be conclusive due to the limited empirical material. Further investigation and analytically richer data are required in order to verify and broaden the findings. More case studies have therefore been planned in order to understand the area better.

Ceramic Technology For Advanced Heat Engines Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-12-01

Significant accomplishments in fabricating ceramic components for the Department of Energy (DOE), National Aeronautics and Space Administration (NASA), and Department of Defense (DoD) advanced heat engine programs have provided evidence that the operation of ceramic parts in high-temperature engine environments is feasible. However, these programs have also demonstrated that additional research is needed in materials and processing development, design methodology, and data base and life prediction before industry will have a sufficient technology base from which to produce reliable cost-effective ceramic engine components commercially. The objective of the project is to develop the industrial technology base required for reliable ceramicsmore » for application in advanced automotive heat engines. The project approach includes determining the mechanisms controlling reliability, improving processes for fabricating existing ceramics, developing new materials with increased reliability, and testing these materials in simulated engine environments to confirm reliability. Although this is a generic materials project, the focus is on the structural ceramics for advanced gas turbine and diesel engines, ceramic bearings and attachments, and ceramic coatings for thermal barrier and wear applications in these engines. This advanced materials technology is being developed in parallel and close coordination with the ongoing DOE and industry proof of concept engine development programs. To facilitate the rapid transfer of this technology to U.S. industry, the major portion of the work is being done in the ceramic industry, with technological support from government laboratories, other industrial laboratories, and universities. Abstracts prepared for appropriate papers.« less

Engineering models for catastrophe risk and their application to insurance

NASA Astrophysics Data System (ADS)

Dong, Weimin

2002-06-01

Internationally earthquake insurance, like all other insurance (fire, auto), adopted actuarial approach in the past, which is, based on historical loss experience to determine insurance rate. Due to the fact that earthquake is a rare event with severe consequence, irrational determination of premium rate and lack of understanding scale of potential loss led to many insurance companies insolvent after Northridge earthquake in 1994. Along with recent advances in earth science, computer science and engineering, computerized loss estimation methodologies based on first principles have been developed to the point that losses from destructive earthquakes can be quantified with reasonable accuracy using scientific modeling techniques. This paper intends to introduce how engineering models can assist to quantify earthquake risk and how insurance industry can use this information to manage their risk in the United States and abroad.

Keratinolytic protease: a green biocatalyst for leather industry.

PubMed

Fang, Zhen; Yong, Yang-Chun; Zhang, Juan; Du, Guocheng; Chen, Jian

2017-11-01

Depilation/unhairing is the crucial but heavy pollution process in leather industry. Traditional inorganic sulfide treatment was the most widely used depilation technique in the past decades, which was usually detrimental to leather quality and resulted in serious environmental pollution. Using biocatalysts to substitute inorganic sulfide showed great advantages in environment protection and unhairing efficiency. Keratinolytic protease is one of the excellent biocatalysts to hydrolyze disulfide bond-rich proteins of hair and has little damage to leather. Biological treatment with keratinolytic proteases could largely reduce the quantity and toxicity of wastewater effluent from the leather industry. But low thermostability and substrate specificity or specific activity of these enzymes limited their practical application. Therefore, recent progresses on protein engineering strategies (site-directed mutagenesis, protein fusion, N/C-terminus truncation, and domain swapping) used to enhance the keratinolytic enzyme performance were presented.

Development of university-industry partnerships in railroad engineering education

NASA Astrophysics Data System (ADS)

Lautala, Pasi T.

Rail transportation has been an important part of the North American transportation network since the 19th century and it continues to be a major contributor to the economic well-being and the global competitiveness of the U.S. The recent expansion in freight rail volumes and forecasts for continuous growth, together with more favorable attitudes for urban passenger rail present several challenges for the rail industry. One of the challenges is the availability of a well educated engineering workforce. The rail industry has recognized a need to attract new railroad professionals from various disciplines for management and technical positions, but most universities eliminated railroad engineering from their curricula after the recruitment levels faded several decades ago. Today, railroad expertise and related engineering courses exist at only a few universities and most students graduate without any exposure to rail topics. While industry representatives have expressed their concern about a future workforce, little data is available on the extent of the demand, on the characteristics and skills of preferred candidates, and on the role that universities can play. A benchmarking study was undertaken to investigate the demand for university engineering graduates and assess whether current methods are sufficient to attract, educate, recruit, train and retain engineering students in the railroad profession. Data was collected from industry human resources and training managers to define the quantitative and qualitative needs for railroad engineers. In addition, recently hired engineers working in the rail industry were surveyed to determine the extent of their university exposure in rail topics and how it affected their career choice. The surveys indicated an increase of over 300 percent in the annual recruitment for railroad engineers by the participating companies between 2002 and 2005. Recruitment levels are expected to remain high for the next five to ten years due to high demand for rail transportation and an older engineering workforce with the greatest demand for civil, electrical and mechanical engineers with bachelor's degrees. The rail industry and universities have grown apart over the past several decades, as rail programs and courses were abandoned at universities and there were very limited recruitment and research activities by the railroads at universities. Today, specialized course(s) in rail topics are offered at approximately three percent of ABET accredited civil engineering programs in the U.S. and only 16 percent of engineers who responded to the survey had received university exposure to rail topics. The research findings suggest that increased university participation has the potential to assist the rail industry in all aspects related to attracting, educating, recruiting, training and retaining engineering graduates. The primary advantages would be greater industry visibility and student knowledge in rail topics. Increased prior knowledge, on the other hand, improves the effectiveness of industry training programs and offers a potential for sizable training cost reductions. As a final conclusion, the research suggests that the most effective approach for developing future railroad engineers is a balancing act where the responsibilities should be shared by the rail industry and universities based on each others strengths. University participation should include multiple types and levels, including introductory lectures, co-op/internship programs, courses in railroad engineering, and a minor or certificate in railroad engineering that would include several courses. Due to the urgent demand for railroad engineers and time it takes to rebuild the expertise on campuses, the development process should begin immediately, be incremental, and utilize concepts, such as cooperation with other universities or engineer-in-residence, that reduce the demand of internal university resources. The challenges to the process, such as willingness of partners to understand each others needs and motivations for the relationship should be alleviated by developing performance goals and measures of success. While it is impossible to evaluate all aspects of university level railroad engineering education in one study, this research suggests that there are opportunities for a partnership between the rail industry and universities. The purpose of this research was to identify those opportunities and increase the understanding of the forces that shape the demand for railroad engineers and engineering education. The findings can be used both by the rail industry and the universities as they initiate change in the current processes and thrive to develop railroad engineers to meet the demands of the 21 st century.

An overview of aerospace gas turbine technology of relevance to the development of the automotive gas turbine engine

NASA Technical Reports Server (NTRS)

Evans, D. G.; Miller, T. J.

1978-01-01

The NASA-Lewis Research Center (LeRC) has conducted, and has sponsored with industry and universities, extensive research into many of the technology areas related to gas turbine propulsion systems. This aerospace-related technology has been developed at both the component and systems level, and may have significant potential for application to the automotive gas turbine engine. This paper summarizes this technology and lists the associated references. The technology areas are system steady-state and transient performance prediction techniques, compressor and turbine design and performance prediction programs and effects of geometry, combustor technology and advanced concepts, and ceramic coatings and materials technology.

Flight-vehicle materials, structures, and dynamics - Assessment and future directions. Vol. 4 - Tribological materials and NDE

NASA Technical Reports Server (NTRS)

Fusaro, Robert L. (Editor); Achenbach, J. D. (Editor)

1993-01-01

The present volume on tribological materials and NDE discusses liquid lubricants for advanced aircraft engines, a liquid lubricant for space applications, solid lubricants for aeronautics, and thin solid-lubricant films in space. Attention is given to the science and technology of NDE, tools for an NDE engineering base, experimental techniques in ultrasonics for NDE and material characterization, and laser ultrasonics. Topics addressed include thermal methods of NDE and quality control, digital radiography in the aerospace industry, materials characterization by ultrasonic methods, and NDE of ceramics and ceramic composites. Also discussed are smart materials and structures, intelligent processing of materials, implementation of NDE technology on flight structures, and solid-state weld evaluation.

Applications

NASA Astrophysics Data System (ADS)

Stern, Arthur M.

1986-07-01

Economic incentives have spurred numerous applications of genetically engineered organisms in manufacture of pharmaceuticals and industrial chemicals. These successes, involving a variety of methods of genetic manipulation, have dispelled early fears that genetic engineering could not be handled safely, even in the laboratory. Consequently, the potential for applications in the wider environment without physical containment is being considered for agriculture, mining, pollution control, and pest control. These proposed applications range from modest extensions of current plant breeding techniques for new disease-resistant species to radical combinations of organisms (for example, nitrogen-fixing corn plants). These applications raise concerns about potential ecological impacts (see chapter 5), largely because of adverse experiences with both deliberate and inadvertent introductions of nonindigenous species.

Simulation of ultrasonic arrays for industrial and civil engineering applications including validation

NASA Astrophysics Data System (ADS)

Spies, M.; Rieder, H.; Orth, Th.; Maack, S.

2012-05-01

In this contribution we address the beam field simulation of 2D ultrasonic arrays using the Generalized Point Source Synthesis technique. Aiming at the inspection of cylindrical components (e.g. pipes) the influence of concave and convex surface curvatures, respectively, has been evaluated for a commercial probe. We have compared these results with those obtained using a commercial simulation tool. In civil engineering, the ultrasonic inspection of highly attenuating concrete structures has been advanced by the development of dry contact point transducers, mainly applied in array arrangements. Our respective simulations for a widely used commercial probe are validated using experimental results acquired on concrete half-spheres with diameters from 200 mm up to 650 mm.

Progress on bioinspired, biomimetic, and bioreplication routes to harvest solar energy

NASA Astrophysics Data System (ADS)

Martín-Palma, Raúl J.; Lakhtakia, Akhlesh

2017-06-01

Although humans have long been imitating biological structures to serve their particular purposes, only a few decades ago engineered biomimicry began to be considered a technoscientific discipline with a great problem-solving potential. The three methodologies of engineered biomimicry-viz., bioinspiration, biomimetic, and bioreplication-employ and impact numerous technoscientific fields. For producing fuels and electricity by artificial photosynthesis, both processes and porous surfaces inspired by plants and certain marine animals are under active investigation. Biomimetically textured surfaces on the subwavelength scale have been shown to reduce the reflectance of photovoltaic solar cells over the visible and the near-infrared regimes. Lenticular compound lenses bioreplicated from insect eyes by an industrially scalable technique offer a similar promise.

An Experimental Introduction to Acoustics

NASA Astrophysics Data System (ADS)

Black, Andy Nicholas; Magruder, Robert H.

2017-11-01

Learning and understanding physics requires more than studying physics texts. It requires doing physics. Doing research is a key opportunity for students to connect physical principles with their everyday experience. A powerful way to introduce students to research and technique is through subjects in which they might find interest. Presented is an experiment that serves to introduce an advanced undergraduate or high school student to conducting research in acoustics via an experiment involving a standard dreadnought acoustic guitar, recording industry-related equipment, and relevant industrial analysis software. This experimental process is applicable to a wide range of acoustical topics including both acoustic and electric instruments. Also, the student has a hands-on experience with relevant audio engineering technology to study physical principles.

Strategies for design of improved biocatalysts for industrial applications.

PubMed

Madhavan, Aravind; Sindhu, Raveendran; Binod, Parameswaran; Sukumaran, Rajeev K; Pandey, Ashok

2017-12-01

Biocatalysts are creating increased interest among researchers due to their unique properties. Several enzymes are efficiently produced by microorganisms. However, the use of natural enzymes as biocatalysts is hindered by low catalytic efficiency and stability during various industrial processes. Many advanced enzyme technologies have been developed to reshape the existing natural enzymes to reduce these limitations and prospecting of novel enzymes. Frequently used enzyme technologies include protein engineering by directed evolution, immobilisation techniques, metagenomics etc. This review summarizes recent and emerging advancements in the area of enzyme technologies for the development of novel biocatalysts and further discusses the future directions in this field. Copyright © 2017 Elsevier Ltd. All rights reserved.

Engineering Graduates' Skill Sets in the MENA Region: A Gap Analysis of Industry Expectations and Satisfaction

ERIC Educational Resources Information Center

Ramadi, Eric; Ramadi, Serge; Nasr, Karim

2016-01-01

This study explored gaps between industry expectations and perceptions of engineering graduates' skill sets in the Middle East and North Africa (MENA) region. This study measured the importance that managers of engineers placed on 36 skills relevant to engineers. Also measured was managers' satisfaction with engineering graduates' skill sets.…

46 CFR 11.530 - Endorsements for engineers of uninspected fishing industry vessels.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Endorsements for engineers of uninspected fishing... MARINE OFFICERS AND SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.530 Endorsements for engineers of uninspected fishing industry vessels. (a) This section...

46 CFR 11.530 - Endorsements for engineers of uninspected fishing industry vessels.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Endorsements for engineers of uninspected fishing... MARINE OFFICERS AND SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.530 Endorsements for engineers of uninspected fishing industry vessels. (a) This section...

46 CFR 11.530 - Endorsements for engineers of uninspected fishing industry vessels.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Endorsements for engineers of uninspected fishing... MARINE OFFICERS AND SEAMEN REQUIREMENTS FOR OFFICER ENDORSEMENTS Professional Requirements for Engineer Officer § 11.530 Endorsements for engineers of uninspected fishing industry vessels. (a) This section...

Why Industry Must Step In to Train Engineers.

ERIC Educational Resources Information Center

Business Week, 1981

1981-01-01

Suggests industrial training of Japanese engineers since engineering education in Japan focuses on abstract science and rote learning of fundamental principles and not on practical laboratory experiences characteristic of training in the United States. (SK)

26 CFR 1.971-1 - Definitions with respect to export trade corporations.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., industrial, financial, technical, scientific, managerial, engineering, architectural, skilled, or other..., industrial, financial, technical, scientific, managerial, engineering, architectural, skilled, or other... performance for any person of commercial, industrial, financial, technical, scientific, managerial...

26 CFR 1.971-1 - Definitions with respect to export trade corporations.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., industrial, financial, technical, scientific, managerial, engineering, architectural, skilled, or other..., industrial, financial, technical, scientific, managerial, engineering, architectural, skilled, or other... performance for any person of commercial, industrial, financial, technical, scientific, managerial...

The Relationship between Job Satisfaction and Intent to Turnover among Software Engineers in the Information Technology Industry

ERIC Educational Resources Information Center

Agada, Chuks N.

2013-01-01

The focus of this study was to examine the relationship between job satisfaction and intent to turnover among software engineers in the information technology (IT) industry. The population that was analyzed in this study was software engineers in the IT industry to determine whether there is a relationship between job satisfaction and intent to…

The Role of Industry in Minority Engineering Programs.

ERIC Educational Resources Information Center

Branigan, Thomas L.

Until recently, U.S. engineering education and American industry drew candidates from only about 43 percent of the potential market--white males. Many segments of American business, education, and government have been involved in a process to increase minority participation in engineering; the 1974 freshmen engineering enrollment for women…

Establishing a "Centre for Engineering Experimentation and Design Simulation": A Step towards Restructuring Engineering Education in India

ERIC Educational Resources Information Center

Venkateswarlu, P.

2017-01-01

Reforms in undergraduate engineering curriculum to produce engineers with entrepreneurial skills should address real-world problems relevant to industry and society with active industry support. Technology-assisted, hands-on projects involving experimentation, design simulation and prototyping will transform graduates into professionals with…

32 CFR 644.424 - Development of public port or industrial facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... industrial facilities upon the available land shall file a written application with the District Engineer... development of public port or industrial facilities, the District Engineer shall give notice of such... 32 National Defense 4 2011-07-01 2011-07-01 false Development of public port or industrial...

32 CFR 644.424 - Development of public port or industrial facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... industrial facilities upon the available land shall file a written application with the District Engineer... development of public port or industrial facilities, the District Engineer shall give notice of such... 32 National Defense 4 2010-07-01 2010-07-01 true Development of public port or industrial...

A project to transfer technology from NASA centers in support of industrial innovation in the midwest

NASA Technical Reports Server (NTRS)

Barr, B. G.

1986-01-01

A technology transfer program utilizing graduate students in mechanical engineering at the University of Kansas was initiated in early 1981. The objective of the program was to encourage industrial innovation in the Midwest through improved industry/university cooperation and the utilization of NASA technology. A related and important aspect of the program was the improvement of graduate engineering education through the involvement of students in the identification and accomplishment of technological objectives in cooperation with scientists at NASA centers and engineers in industry. The pilot NASA/University Industrial Innovation Program was an outstanding success based on its ability to: attract top graduate students; secure industry support; and stimulate industry/university cooperation leading to enhanced university capability and utilization of advanced technology by industry.

Crystallization techniques in wastewater treatment: An overview of applications.

PubMed

Lu, Haijiao; Wang, Jingkang; Wang, Ting; Wang, Na; Bao, Ying; Hao, Hongxun

2017-04-01

As a by-product of industrial or domestic activities, wastewater of different compositions has caused serious environmental problems all over the world. Facing the challenge of wastewater treatment, researchers have begun to make use of crystallization techniques in wastewater treatment. Crystallization techniques have many advantages, such as high efficiency, energy saving, low costs, less space occupation and so on. In recent decades, crystallization is considered as one of promising techniques for wastewater treatment, especially for desalination, water and salt recovery. It has been widely used in engineering applications all over the world. In this paper, various crystallization techniques in wastewater treatment are summarized, mainly including evaporation crystallization, cooling crystallization, reaction crystallization, drowning-out crystallization and membrane distillation crystallization. Overall, they are mainly used for desalination, water and salt recovery. Their applications, advantages and disadvantages were compared and discussed in detail. Copyright © 2017 Elsevier Ltd. All rights reserved.

Perspectives and Plans for Graduate Studies. 11. Engineering 1974. E. Industrial Engineering and Systems Design. Report No. 74-22.

ERIC Educational Resources Information Center

Ontario Council on Graduate Studies, Toronto. Advisory Committee on Academic Planning.

On the instruction of the Council of Ontario Universities, the Advisory Committee on Academic Planning in cooperation with the Committee of Ontario Deans of Engineering has conducted a planning assessment for doctoral work in industrial engineering and systems design. Recommendations for doctoral work in engineering studies are presented.…

15 CFR 801.9 - Reports required.

Code of Federal Regulations, 2011 CFR

2011-01-01

...); industrial engineering services; industrial-type maintenance, installation, alteration, and training services... services; educational and training services; engineering, architectural, and surveying services; financial... assets covered by the BE-125 survey are rights related to: Industrial processes and products; books...

15 CFR 801.9 - Reports required.

Code of Federal Regulations, 2010 CFR

2010-01-01

...); industrial engineering services; industrial-type maintenance, installation, alteration, and training services... services; educational and training services; engineering, architectural, and surveying services; financial... assets covered by the BE-125 survey are rights related to: Industrial processes and products; books...

15 CFR 801.9 - Reports required.

Code of Federal Regulations, 2012 CFR

2012-01-01

...); industrial engineering services; industrial-type maintenance, installation, alteration, and training services... services; educational and training services; engineering, architectural, and surveying services; financial... assets covered by the BE-125 survey are rights related to: Industrial processes and products; books...

Evolutionary engineering of industrial microorganisms-strategies and applications.

PubMed

Zhu, Zhengming; Zhang, Juan; Ji, Xiaomei; Fang, Zhen; Wu, Zhimeng; Chen, Jian; Du, Guocheng

2018-06-01

Microbial cells have been widely used in the industry to obtain various biochemical products, and evolutionary engineering is a common method in biological research to improve their traits, such as high environmental tolerance and improvement of product yield. To obtain better integrate functions of microbial cells, evolutionary engineering combined with other biotechnologies have attracted more attention in recent years. Classical laboratory evolution has been proven effective to letting more beneficial mutations occur in different genes but also has some inherent limitations such as a long evolutionary period and uncontrolled mutation frequencies. However, recent studies showed that some new strategies may gradually overcome these limitations. In this review, we summarize the evolutionary strategies commonly used in industrial microorganisms and discuss the combination of evolutionary engineering with other biotechnologies such as systems biology and inverse metabolic engineering. Finally, we prospect the importance and application prospect of evolutionary engineering as a powerful tool especially in optimization of industrial microbial cell factories.

Pharmaceutical and industrial protein engineering: where we are?

PubMed

Amara, Amro Abd-Al-Fattah

2013-01-01

The huge amount of information, the big number of scientists and their efforts, labs, man/hrs, fund, companies all and others factors build the success of the amazing new branch of genetic engineering the 'protein engineering' (PE). It concerns with the modification of protein structure/function(s) or building protein from scratch. The engineered proteins usually have new criteria(s). Engineering proteins can be mediated on the level of genes or proteins. PE fined its way in different important sectors including industrial, pharmaceutical and medicinal ones. Aspects about PE and its applications will be discussed with this review. The concept, tools, and the industrial applications of the protein, engineered proteins and PE will be under focus. In order to get up to date knowledge about the applications of PE in basic protein and molecular biology, several examples are discussed. PE can play a significant role in different industrial and pharmaceutical sectors if used wisely and selectively.

A Guide to the George Palmiter River Restoration Techniques.

DTIC Science & Technology

1982-03-01

reduction. The raft is driven by a 35 h.p. ’ outboard engine, weighs 4 tons, and has 1500 lb. of flotation material under it. Additionally, the raft has a...Sycamore (Platanus occidentalis) 4. Red Maple (Acer rubrum) 5. Silver Maple (Acer saccharinum) 6. Pin Oak (Quercus palustris) 7. Red Oak (Quercus...safety goggles 5 - ear protectors 5 - flotation jackets 1, - industrial first aid kit--one that floats and is waterproof 1 - snake bite kit several

The National Shipbuilding Research Program. Application of Industrial Engineering Techniques to Reduce Workers’ Compensation and Environmental Costs - Deliverable D

DTIC Science & Technology

1999-10-01

Electrostatic guns provide opportunities for exterior application of topcoats such as urethanes, acrylics , alkyds and epoxies. Most shipbuilding...A hybrid of airless spray and conventional air-atomized spray, this kind of gun uses fluid pressures higher than those used in conventional air...voltage) by simply flipping a switch. All essential controls are located right at the back of the gun. Other electrostatic systems require constant

A High-Fidelity Simulation of a Generic Commercial Aircraft Engine and Controller

NASA Technical Reports Server (NTRS)

May, Ryan D.; Csank, Jeffrey; Lavelle, Thomas M.; Litt, Jonathan S.; Guo, Ten-Huei

2010-01-01

A new high-fidelity simulation of a generic 40,000 lb thrust class commercial turbofan engine with a representative controller, known as CMAPSS40k, has been developed. Based on dynamic flight test data of a highly instrumented engine and previous engine simulations developed at NASA Glenn Research Center, this non-proprietary simulation was created especially for use in the development of new engine control strategies. C-MAPSS40k is a highly detailed, component-level engine model written in MATLAB/Simulink (The MathWorks, Inc.). Because the model is built in Simulink, users have the ability to use any of the MATLAB tools for analysis and control system design. The engine components are modeled in C-code, which is then compiled to allow faster-than-real-time execution. The engine controller is based on common industry architecture and techniques to produce realistic closed-loop transient responses while ensuring that no safety or operability limits are violated. A significant feature not found in other non-proprietary models is the inclusion of transient stall margin debits. These debits provide an accurate accounting of the compressor surge margin, which is critical in the design of an engine controller. This paper discusses the development, characteristics, and capabilities of the C-MAPSS40k simulation

Preface to RIGiM 2009

NASA Astrophysics Data System (ADS)

Rolland, Colette; Yu, Eric; Salinesi, Camille; Castro, Jaelson

The use of intentional concepts, the notion of "goal" in particular, has been prominent in recent approaches to requirement engineering (RE). Goal-oriented frameworks and methods for requirements engineering (GORE) have been keynote topics in requirements engineering, conceptual modelling, and more generally in software engineering. What are the conceptual modelling foundations in these approaches? RIGiM (Requirements Intentions and Goals in Conceptual Modelling) aims to provide a forum for discussing the interplay between requirements engineering and conceptual modelling, and in particular, to investigate how goal- and intention-driven approaches help in conceptualising purposeful systems. What are the fundamental objectives and premises of requirements engineering and conceptual modelling respectively, and how can they complement each other? What are the demands on conceptual modelling from the standpoint of requirements engineering? What conceptual modelling techniques can be further taken advantage of in requirements engineering? What are the upcoming modelling challenges and issues in GORE? What are the unresolved open questions? What lessons are there to be learnt from industrial experiences? What empirical data are there to support the cost-benefit analysis when adopting GORE methods? Are there application domains or types of project settings for which goals and intentional approaches are particularly suitable or not suitable? What degree of formalization and automation, or interactivity is feasible and appropriate for what types of participants during requirements engineering?

Fast engineering optimization: A novel highly effective control parameterization approach for industrial dynamic processes.

PubMed

Liu, Ping; Li, Guodong; Liu, Xinggao

2015-09-01

Control vector parameterization (CVP) is an important approach of the engineering optimization for the industrial dynamic processes. However, its major defect, the low optimization efficiency caused by calculating the relevant differential equations in the generated nonlinear programming (NLP) problem repeatedly, limits its wide application in the engineering optimization for the industrial dynamic processes. A novel highly effective control parameterization approach, fast-CVP, is first proposed to improve the optimization efficiency for industrial dynamic processes, where the costate gradient formulae is employed and a fast approximate scheme is presented to solve the differential equations in dynamic process simulation. Three well-known engineering optimization benchmark problems of the industrial dynamic processes are demonstrated as illustration. The research results show that the proposed fast approach achieves a fine performance that at least 90% of the computation time can be saved in contrast to the traditional CVP method, which reveals the effectiveness of the proposed fast engineering optimization approach for the industrial dynamic processes. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

Industrial Strength Changes in Engineering Education.

ERIC Educational Resources Information Center

Chatziioanou, Alypios; Sullivan, Edward

2002-01-01

Addresses the question of how closely the objectives of industry and engineering education should be aligned. Examines trends in college-business relationships using the example of California Polytechnic State University. Reflects on benefits and problems of closer connections with industry. (SK)

Case Study: Meeting the Demand for Skilled Precision Engineers

ERIC Educational Resources Information Center

Sansom, Chris; Shore, Paul

2008-01-01

Purpose: This paper aims to demonstrate how science and engineering graduates can be recruited and trained to Masters level in precision engineering as an aid to reducing the skills shortage of mechanical engineers in UK industry. Design/methodology/approach: The paper describes a partnership between three UK academic institutions and industry,…

Three-Dimensional Bioprinting: Toward the Era of Manufacturing Human Organs as Spare Parts for Healthcare and Medicine^.

PubMed

Mir, Tanveer Ahmad; Nakamura, Makoto

2017-06-01

Three-dimensional (3D) printing technology has been used in industrial worlds for decades. Three-dimensional bioprinting has recently received an increasing attention across the globe among researchers, academicians, students, and even the ordinary people. This emerging technique has a great potential to engineer highly organized functional bioconstructs with complex geometries and tailored components for engineering bioartificial tissues/organs for widespread applications, including transplantation, therapeutic investigation, drug development, bioassay, and disease modeling. Although many specialized 3D printers have been developed and applied to print various types of 3D tissue constructs, bioprinting technologies still have several technical challenges, including high resolution distribution of cells, controlled deposition of bioinks, suitable bioink materials, maturation of cells, and effective vascularization and innervation within engineered complex structures. In this brief review, we discuss about bioprinting approach, current limitations, and possibility of future advancements for producing engineered bioconstructs and bioartificial organs with desired functionalities.

Business process re-engineering--saviour or just another fad? One UK health care perspective.

PubMed

Patwardhan, Anjali; Patwardhan, Dhruv

2008-01-01

Pressure to change is politically driven owing to escalating healthcare costs and an emphasis on efficiency gains, value for money and improved performance proof in terms of productivity and recently to some extent by demands from less satisfied patients and stakeholders. In a background of newly immerging expensive techniques and drugs, there is an increasing consumer expectation, i.e. quality services. At the same time, health system managers and practitioners are finding it difficult to cope with demand and quality expectations. Clinicians are frustrated because they are not recognised for their contribution. Managers are frustrated because meaningful dialogue with clinicians is lacking, which has intensified the need for change to a more efficient system that satisfies all arguments about cost effectiveness and sustainable quality services. Various strategies, originally developed by management quality "gurus" for engineering industries, have been applied to health industries with variable success, which largely depends on the type of health care system to which they are applied. Business process re-engineering is examined as a quality management tool using past and recent publications. The paper finds that applying business process re-engineering in the right circumstances and selected settings for quality improvement is critical for its success. It is certainly "not for everybody". The paper provides a critical appraisal of business process re-engineering experiences in UK healthcare. Lessons learned regarding selecting organisations and agreeing realistic expectations are addressed. Business process re-engineering has been evaluated and reviewed since 1987 in US managed health care, with no clear lessons learned possibly because unit selection and simultaneous comparison between two units virtually performing at opposite ends has never been done before. Two UK pilot studies, however, add useful insights.

Digital terrain modeling and industrial surface metrology: Converging realms

USGS Publications Warehouse

Pike, R.J.

2001-01-01

Digital terrain modeling has a micro-and nanoscale counterpart in surface metrology, the numerical characterization of industrial surfaces. Instrumentation in semiconductor manufacturing and other high-technology fields can now contour surface irregularities down to the atomic scale. Surface metrology has been revolutionized by its ability to manipulate square-grid height matrices that are analogous to the digital elevation models (DEMs) used in physical geography. Because the shaping of industrial surfaces is a spatial process, the same concepts of analytical cartography that represent ground-surface form in geography evolved independently in metrology: The surface topography of manufactured components, exemplified here by automobile-engine cylinders, is routinely modeled by variogram analysis, relief shading, and most other techniques of parameterization and visualization familiar to geography. This article introduces industrial surface-metrology, examines the field in the context of terrain modeling and geomorphology and notes their similarities and differences, and raises theoretical issues to be addressed in progressing toward a unified practice of surface morphometry.

Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging.

PubMed

Badano, Luigi P; Kolias, Theodore J; Muraru, Denisa; Abraham, Theodore P; Aurigemma, Gerard; Edvardsen, Thor; D'Hooge, Jan; Donal, Erwan; Fraser, Alan G; Marwick, Thomas; Mertens, Luc; Popescu, Bogdan A; Sengupta, Partho P; Lancellotti, Patrizio; Thomas, James D; Voigt, Jens-Uwe

2018-03-27

The EACVI/ASE/Industry Task Force to standardize deformation imaging prepared this consensus document to standardize definitions and techniques for using two-dimensional (2D) speckle tracking echocardiography (STE) to assess left atrial, right ventricular, and right atrial myocardial deformation. This document is intended for both the technical engineering community and the clinical community at large to provide guidance on selecting the functional parameters to measure and how to measure them using 2D STE.This document aims to represent a significant step forward in the collaboration between the scientific societies and the industry since technical specifications of the software packages designed to post-process echocardiographic datasets have been agreed and shared before their actual development. Hopefully, this will lead to more clinically oriented software packages which will be better tailored to clinical needs and will allow industry to save time and resources in their development.

Analysis of Internet Information on Lateral Lumbar Interbody Fusion.

PubMed

Belayneh, Rebekah; Mesfin, Addisu

2016-07-01

Lateral lumbar interbody fusion (LLIF) is a surgical technique that is being increasingly used. The authors' objective was to examine information on the Internet pertaining to the LLIF technique. An analysis was conducted of publicly accessible websites pertaining to LLIF. The following search engines were used: Google (www.google.com), Bing (www.bing.com), and Yahoo (www.yahoo.com). DuckDuckGo (www.duckduckgo.com) was an additional search engine used due to its emphasis on generating accurate and consistent results while protecting searchers' privacy and reducing advertisements. The top 35 websites providing information on LLIF from the 4 search engines were identified. A total of 140 websites were evaluated. Each web-site was categorized based on authorship (academic, private, medical industry, insurance company, other) and content of information. Using the search term lateral lumbar interbody fusion, 174,000 Google results, 112,000 Yahoo results, and 112,000 Bing results were obtained. DuckDuckGo does not display the number of results found for a search. From the top 140 websites collected from each website, 78 unique websites were identified. Websites were authored by a private medical group in 46.2% of the cases, an academic medical group in 26.9% of the cases, and the biomedical industry in 5.1% of the cases. Sixty-eight percent of websites reported indications, and 24.4% reported contraindications. Benefits of LLIF were reported by 69.2% of websites. Thirty-six percent of websites reported complications of LLIF. Overall, the quality of information regarding LLIF on the Internet is poor. Spine surgeons and spine societies can assist in improving the quality of the information on the Internet regarding LLIF. [Orthopedics. 2016; 39(4):e701-e707.]. Copyright 2016, SLACK Incorporated.

Perm State University HPC-hardware and software services: capabilities for aircraft engine aeroacoustics problems solving

NASA Astrophysics Data System (ADS)

Demenev, A. G.

2018-02-01

The present work is devoted to analyze high-performance computing (HPC) infrastructure capabilities for aircraft engine aeroacoustics problems solving at Perm State University. We explore here the ability to develop new computational aeroacoustics methods/solvers for computer-aided engineering (CAE) systems to handle complicated industrial problems of engine noise prediction. Leading aircraft engine engineering company, including “UEC-Aviadvigatel” JSC (our industrial partners in Perm, Russia), require that methods/solvers to optimize geometry of aircraft engine for fan noise reduction. We analysed Perm State University HPC-hardware resources and software services to use efficiently. The performed results demonstrate that Perm State University HPC-infrastructure are mature enough to face out industrial-like problems of development CAE-system with HPC-method and CFD-solvers.

48 CFR 206.302-3 - Industrial mobilization; or engineering, development, or research capability.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Industrial mobilization; or engineering, development, or research capability. 206.302-3 Section 206.302-3 Federal Acquisition... engineering, development, or research capability. ...

48 CFR 206.302-3 - Industrial mobilization; or engineering, development, or research capability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial mobilization; or engineering, development, or research capability. 206.302-3 Section 206.302-3 Federal Acquisition... engineering, development, or research capability. ...

48 CFR 206.302-3 - Industrial mobilization; or engineering, development, or research capability.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Industrial mobilization; or engineering, development, or research capability. 206.302-3 Section 206.302-3 Federal Acquisition... engineering, development, or research capability. ...

Profiles of Automotive Suppliers Industries--Engineered Mechanical Components and Systems : Volume II, Appendices.

DOT National Transportation Integrated Search

1981-09-01

The profile describes and analyzes that segment of the automotive supplier industry which provides engineered mechanical components/assemblies/systems to the prime auto manufacturers. It presents an overview of the role and structure of this industry...

Biocatalysis in the Pharmaceutical Industry: The Need for Speed

PubMed Central

2017-01-01

The use of biocatalysis in the pharmaceutical industry continues to expand as a result of increased access to enzymes and the ability to engineer those enzymes to meet the demands of industrial processes. However, we are still just scratching the surface of potential biocatalytic applications. The time pressures present in pharmaceutical process development are incompatible with the long lead times required for engineering a suitable biocatalyst. Dramatic increases in the speed of protein engineering are needed to deliver on the ever increasing opportunities for industrial biocatalytic processes. PMID:28523096

Biocatalysis in the Pharmaceutical Industry: The Need for Speed.

PubMed

Truppo, Matthew D

2017-05-11

The use of biocatalysis in the pharmaceutical industry continues to expand as a result of increased access to enzymes and the ability to engineer those enzymes to meet the demands of industrial processes. However, we are still just scratching the surface of potential biocatalytic applications. The time pressures present in pharmaceutical process development are incompatible with the long lead times required for engineering a suitable biocatalyst. Dramatic increases in the speed of protein engineering are needed to deliver on the ever increasing opportunities for industrial biocatalytic processes.

de novo computational enzyme design.

PubMed

Zanghellini, Alexandre

2014-10-01

Recent advances in systems and synthetic biology as well as metabolic engineering are poised to transform industrial biotechnology by allowing us to design cell factories for the sustainable production of valuable fuels and chemicals. To deliver on their promises, such cell factories, as much as their brick-and-mortar counterparts, will require appropriate catalysts, especially for classes of reactions that are not known to be catalyzed by enzymes in natural organisms. A recently developed methodology, de novo computational enzyme design can be used to create enzymes catalyzing novel reactions. Here we review the different classes of chemical reactions for which active protein catalysts have been designed as well as the results of detailed biochemical and structural characterization studies. We also discuss how combining de novo computational enzyme design with more traditional protein engineering techniques can alleviate the shortcomings of state-of-the-art computational design techniques and create novel enzymes with catalytic proficiencies on par with natural enzymes. Copyright © 2014 Elsevier Ltd. All rights reserved.

Variability-aware double-patterning layout optimization for analog circuits

NASA Astrophysics Data System (ADS)

Li, Yongfu; Perez, Valerio; Tripathi, Vikas; Lee, Zhao Chuan; Tseng, I.-Lun; Ong, Jonathan Yoong Seang

2018-03-01

The semiconductor industry has adopted multi-patterning techniques to manage the delay in the extreme ultraviolet lithography technology. During the design process of double-patterning lithography layout masks, two polygons are assigned to different masks if their spacing is less than the minimum printable spacing. With these additional design constraints, it is very difficult to find experienced layout-design engineers who have a good understanding of the circuit to manually optimize the mask layers in order to minimize color-induced circuit variations. In this work, we investigate the impact of double-patterning lithography on analog circuits and provide quantitative analysis for our designers to select the optimal mask to minimize the circuit's mismatch. To overcome the problem and improve the turn-around time, we proposed our smart "anchoring" placement technique to optimize mask decomposition for analog circuits. We have developed a software prototype that is capable of providing anchoring markers in the layout, allowing industry standard tools to perform automated color decomposition process.

High-efficiency genome editing and allele replacement in prototrophic and wild strains of Saccharomyces.

PubMed

Alexander, William G; Doering, Drew T; Hittinger, Chris Todd

2014-11-01

Current genome editing techniques available for Saccharomyces yeast species rely on auxotrophic markers, limiting their use in wild and industrial strains and species. Taking advantage of the ancient loss of thymidine kinase in the fungal kingdom, we have developed the herpes simplex virus thymidine kinase gene as a selectable and counterselectable marker that forms the core of novel genome engineering tools called the H: aploid E: ngineering and R: eplacement P: rotocol (HERP) cassettes. Here we show that these cassettes allow a researcher to rapidly generate heterogeneous populations of cells with thousands of independent chromosomal allele replacements using mixed PCR products. We further show that the high efficiency of this approach enables the simultaneous replacement of both alleles in diploid cells. Using these new techniques, many of the most powerful yeast genetic manipulation strategies are now available in wild, industrial, and other prototrophic strains from across the diverse Saccharomyces genus. Copyright © 2014 by the Genetics Society of America.

Techniques and instrumentation for the measurement of transient sound energy flux

NASA Astrophysics Data System (ADS)

Watkinson, P. S.; Fahy, F. J.

1983-12-01

The evaluation of sound intensity distributions, and sound powers, of essentially continuous sources such as automotive engines, electric motors, production line machinery, furnaces, earth moving machinery and various types of process plants were studied. Although such systems are important sources of community disturbance and, to a lesser extent, of industrial health hazard, the most serious sources of hearing hazard in industry are machines operating on an impact principle, such as drop forges, hammers and punches. Controlled experiments to identify major noise source regions and mechanisms are difficult because it is normally impossible to install them in quiet, anechoic environments. The potential for sound intensity measurement to provide a means of overcoming these difficulties has given promising results, indicating the possibility of separation of directly radiated and reverberant sound fields. However, because of the complexity of transient sound fields, a fundamental investigation is necessary to establish the practicability of intensity field decomposition, which is basic to source characterization techniques.

A hydrogen-oxygen rocket engine coolant passage design program (RECOP) for fluid-cooled thrust chambers and nozzles

NASA Technical Reports Server (NTRS)

Tomsik, Thomas M.

1994-01-01

The design of coolant passages in regeneratively cooled thrust chambers is critical to the operation and safety of a rocket engine system. Designing a coolant passage is a complex thermal and hydraulic problem requiring an accurate understanding of the heat transfer between the combustion gas and the coolant. Every major rocket engine company has invested in the development of thrust chamber computer design and analysis tools; two examples are Rocketdyne's REGEN code and Aerojet's ELES program. In an effort to augment current design capabilities for government and industry, the NASA Lewis Research Center is developing a computer model to design coolant passages for advanced regeneratively cooled thrust chambers. The RECOP code incorporates state-of-the-art correlations, numerical techniques and design methods, certainly minimum requirements for generating optimum designs of future space chemical engines. A preliminary version of the RECOP model was recently completed and code validation work is in progress. This paper introduces major features of RECOP and compares the analysis to design points for the first test case engine; the Pratt & Whitney RL10A-3-3A thrust chamber.

Thermophilic xylanases: from bench to bottle.

PubMed

Basit, Abdul; Liu, Junquan; Rahim, Kashif; Jiang, Wei; Lou, Huiqiang

2018-01-17

Lignocellulosic biomass is a valuable raw material. As technology has evolved, industrial interest in new ways to take advantage of this raw material has grown. Biomass is treated with different microbial cells or enzymes under ideal industrial conditions to produce the desired products. Xylanases are the key enzymes that degrade the xylosidic linkages in the xylan backbone of the biomass, and commercial enzymes are categorized into different glycoside hydrolase families. Thermophilic microorganisms are excellent sources of industrially relevant thermostable enzymes that can withstand the harsh conditions of industrial processing. Thermostable xylanases display high-specific activity at elevated temperatures and distinguish themselves in biochemical properties, structures, and modes of action from their mesophilic counterparts. Natural xylanases can be further improved through genetic engineering. Rapid progress with genome editing, writing, and synthetic biological techniques have provided unlimited potential to produce thermophilic xylanases in their natural hosts or cell factories including bacteria, yeasts, and filamentous fungi. This review will discuss the biotechnological potential of xylanases from thermophilic microorganisms and the ways they are being optimized and produced for various industrial applications.

Can 100Gb/s wavelengths be deployed using 10Gb/s engineering rules?

NASA Astrophysics Data System (ADS)

Saunders, Ross; Nicholl, Gary; Wollenweber, Kevin; Schmidt, Ted

2007-09-01

A key challenge set by carriers for 40Gb/s deployments was that the 40Gb/s wavelengths should be deployable over existing 10Gb/s DWDM systems, using 10Gb/s link engineering design rules. Typical 10Gb/s link engineering rules are: 1. Polarization Mode Dispersion (PMD) tolerance of 10ps (mean); 2. Chromatic Dispersion (CD) tolerance of +/-700ps/nm 3. Operation at 50GHz channel spacing, including transit through multiple cascaded [R]OADMs; 4. Optical reach up to 2,000km. By using a combination of advanced modulation formats and adaptive dispersion compensation (technologies rarely seen at 10Gb/s outside of the submarine systems space), vendors did respond to the challenge and broadly met this requirement. As we now start to explore feasible technologies for 100Gb/s optical transport, driven by 100GE port availability on core IP routers, the carrier challenge remains the same. 100Gb/s links should be deployable over existing 10Gb/s DWDM systems using 10Gb/s link engineering rules (as listed above). To meet this challenge, optical transport technology must evolve to yet another level of complexity/maturity in both modulation formats and adaptive compensation techniques. Many clues as to how this might be achieved can be gained by first studying sister telecommunications industries, e.g. satellite (QPSK, QAM, LDCP FEC codes), wireless (advanced DSP, MSK), HDTV (TCM), etc. The optical industry is not a pioneer of new ideas in modulation schemes and coding theory, we will always be followers. However, we do have the responsibility of developing the highest capacity "modems" on the planet to carry the core backbone traffic of the Internet. As such, the key to our success will be to analyze the pros and cons of advanced modulation/coding techniques and balance this with the practical limitations of high speed electronics processing speed and the challenges of real world optical layer impairments. This invited paper will present a view on what advanced technologies are likely candidates to support 100GE optical IP transport over existing 10Gb/s DWDM systems, using 10Gb/s link engineering rules.

Physics and Process Modeling (PPM) and Other Propulsion R and T. Volume 1; Materials Processing, Characterization, and Modeling; Lifting Models

NASA Technical Reports Server (NTRS)

1997-01-01

This CP contains the extended abstracts and presentation figures of 36 papers presented at the PPM and Other Propulsion R&T Conference. The focus of the research described in these presentations is on materials and structures technologies that are parts of the various projects within the NASA Aeronautics Propulsion Systems Research and Technology Base Program. These projects include Physics and Process Modeling; Smart, Green Engine; Fast, Quiet Engine; High Temperature Engine Materials Program; and Hybrid Hyperspeed Propulsion. Also presented were research results from the Rotorcraft Systems Program and work supported by the NASA Lewis Director's Discretionary Fund. Authors from NASA Lewis Research Center, industry, and universities conducted research in the following areas: material processing, material characterization, modeling, life, applied life models, design techniques, vibration control, mechanical components, and tribology. Key issues, research accomplishments, and future directions are summarized in this publication.

3D laser scanning in civil engineering - measurements of volume of earth masses

NASA Astrophysics Data System (ADS)

Pawłowicz, J. A.; Szafranko, E.; Harasymiuk, J.

2018-03-01

Considering the constant drive to improve and accelerate building processes as well as possible applications of the latest technological achievements in civil engineering practice, the author has proposed to use 3D laser scanning in the construction industry. For example, data achieved through a 3D laser scanning process will facilitate making inventories of parameters of buildings in a very short time, will enable one to check irregularly shaped masses of earth, heavy and practically impossible to calculate precisely using traditional techniques. The other part of the research, performed in the laboratory, consisted of measurements of a model mound of earth. All the measurements were made with a 3D SkanStation C10 laser scanner manufactured by Leica. The data were analyzed. The results suggest that there are great opportunities for using the laser scanning technology in civil engineering

China’s Aerospace Industry: Technology, Funding and Modernization

DTIC Science & Technology

1992-01-01

7 was to use a General Electric F404 engine (from the F-20 Tigershark) along with other foreign engines as candidates but that program was again...firms like General Electric and Pratt & Whitney. As the Chinese engine industry gets more behind, more foreign engines are chosen, and the factories have... Electric since 1984.81 Liming Engine Plant makes compressor disks and turbine disks for GE and turbine disks for Pratt & Whitney while the Chengdu Engine

NRL Fact Book

DTIC Science & Technology

2002-11-01

CRADAs) under which NRL scientists and engineers work together with industry , academia, state or local governments, or other Federal agencies to... industrial hygiene, and environ- mental safety. The Division provides engineering and technical assistance to research divisions in the installation...The NRL Women in Science and Engineer - ing (WISE) Network is an open-membership network group of scientists and engineers who meet periodically to

Institute-Industry Interoperation Model: An Industry-Oriented Engineering Education Strategy in China

ERIC Educational Resources Information Center

Wang, Yanqing; Qi, Zhongying; Li, Ziru; Zhang, Lijie

2011-01-01

Engineering education has been well implemented in the majority of developed countries such as the USA, Germany, and the United Kingdom so that the gap between engineering science and engineering practice is greatly bridged. However, in China, the gap still exists, and some attempts by Chinese government, even though having made obvious progress,…

A Multidisciplinary PBL Approach for Teaching Industrial Informatics and Robotics in Engineering

ERIC Educational Resources Information Center

Calvo, Isidro; Cabanes, Itziar; Quesada, Jeronimo; Barambones, Oscar

2018-01-01

This paper describes the design of an industrial informatics course, following the project-based learning methodology, and reports the experience of four academic years (from 2012-13 to 2015-16). Industrial Informatics is a compulsory course taught in the third year of the B.Sc. degree in industrial electronics and automation engineering at the…

[Some engineering problems on developing production industry of modern traditional Chinese medicine].

PubMed

Qu, Hai-bin; Cheng, Yi-yu; Wang, Yue-sheng

2003-10-01

Based on the review of some engineering problems on developing modern production industry of Traditional Chinese Medicine (TCM), the differences of TCM production industry between China and abroad were pointed out. Accelerating the application and extension of high-tech and computer integrated manufacturing system (CIMS) were suggested to promote the technology advancement of TCM industry.

Phase-shift focus monitoring techniques

NASA Astrophysics Data System (ADS)

McQuillan, Matthew; Roberts, Bill

2006-03-01

Depth of focus (DOF) has become a victim of its mathematical relationship with Numerical Aperture (NA). While NA is being increased towards one to maximize scanner resolution capabilities, DOF is being minimized because of its inverse relationship with NA. Moore's law continues to drive the semiconductor industry towards smaller and smaller devices the need for high NA to resolve these shrinking devices will continue to consume the usable depth of focus (UDOF). Due to the shrinking UDOF a demand has been created for a feature or technology that will give engineers the capability to monitor scanner focus. Developing and implementation of various focus monitoring techniques have been used to prevent undetected tool focus excursions. Two overlay techniques to monitor ArF Scanner focus have been evaluated; our evaluation results will be presented here.

Atomic layer deposition (ALD): A versatile technique for plasmonics and nanobiotechnology.

PubMed

Im, Hyungsoon; Wittenberg, Nathan J; Lindquist, Nathan C; Oh, Sang-Hyun

2012-02-28

While atomic layer deposition (ALD) has been used for many years as an industrial manufacturing method for microprocessors and displays, this versatile technique is finding increased use in the emerging fields of plasmonics and nanobiotechnology. In particular, ALD coatings can modify metallic surfaces to tune their optical and plasmonic properties, to protect them against unwanted oxidation and contamination, or to create biocompatible surfaces. Furthermore, ALD is unique among thin-film deposition techniques in its ability to meet the processing demands for engineering nanoplasmonic devices, offering conformal deposition of dense and ultra-thin films on high-aspect-ratio nanostructures at temperatures below 100 °C. In this review, we present key features of ALD and describe how it could benefit future applications in plasmonics, nanosciences, and biotechnology.

Engineering English and the High-Tech Industry: A Case Study of an English Needs Analysis of Process Integration Engineers at a Semiconductor Manufacturing Company in Taiwan

ERIC Educational Resources Information Center

Spence, Paul; Liu, Gi-Zen

2013-01-01

The global high-tech industry is characterized by extreme competitiveness, innovation, and widespread use of English. Consequently, Taiwanese high-tech companies require engineers that are talented in both their engineering and English abilities. In response to the lack of knowledge regarding the English skills needed by engineers in Taiwan's…

Computer-aided design for metabolic engineering.

PubMed

Fernández-Castané, Alfred; Fehér, Tamás; Carbonell, Pablo; Pauthenier, Cyrille; Faulon, Jean-Loup

2014-12-20

The development and application of biotechnology-based strategies has had a great socio-economical impact and is likely to play a crucial role in the foundation of more sustainable and efficient industrial processes. Within biotechnology, metabolic engineering aims at the directed improvement of cellular properties, often with the goal of synthesizing a target chemical compound. The use of computer-aided design (CAD) tools, along with the continuously emerging advanced genetic engineering techniques have allowed metabolic engineering to broaden and streamline the process of heterologous compound-production. In this work, we review the CAD tools available for metabolic engineering with an emphasis, on retrosynthesis methodologies. Recent advances in genetic engineering strategies for pathway implementation and optimization are also reviewed as well as a range of bionalytical tools to validate in silico predictions. A case study applying retrosynthesis is presented as an experimental verification of the output from Retropath, the first complete automated computational pipeline applicable to metabolic engineering. Applying this CAD pipeline, together with genetic reassembly and optimization of culture conditions led to improved production of the plant flavonoid pinocembrin. Coupling CAD tools with advanced genetic engineering strategies and bioprocess optimization is crucial for enhanced product yields and will be of great value for the development of non-natural products through sustainable biotechnological processes. Copyright © 2014 Elsevier B.V. All rights reserved.

CRISPR technologies for bacterial systems: Current achievements and future directions.

PubMed

Choi, Kyeong Rok; Lee, Sang Yup

2016-11-15

Throughout the decades of its history, the advances in bacteria-based bio-industries have coincided with great leaps in strain engineering technologies. Recently unveiled clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) systems are now revolutionizing biotechnology as well as biology. Diverse technologies have been derived from CRISPR/Cas systems in bacteria, yet the applications unfortunately have not been actively employed in bacteria as extensively as in eukaryotic organisms. A recent trend of engineering less explored strains in industrial microbiology-metabolic engineering, synthetic biology, and other related disciplines-is demanding facile yet robust tools, and various CRISPR technologies have potential to cater to the demands. Here, we briefly review the science in CRISPR/Cas systems and the milestone inventions that enabled numerous CRISPR technologies. Next, we describe CRISPR/Cas-derived technologies for bacterial strain development, including genome editing and gene expression regulation applications. Then, other CRISPR technologies possessing great potential for industrial applications are described, including typing and tracking of bacterial strains, virome identification, vaccination of bacteria, and advanced antimicrobial approaches. For each application, we note our suggestions for additional improvements as well. In the same context, replication of CRISPR/Cas-based chromosome imaging technologies developed originally in eukaryotic systems is introduced with its potential impact on studying bacterial chromosomal dynamics. Also, the current patent status of CRISPR technologies is reviewed. Finally, we provide some insights to the future of CRISPR technologies for bacterial systems by proposing complementary techniques to be developed for the use of CRISPR technologies in even wider range of applications. Copyright © 2016. Published by Elsevier Inc.

Statistics for nuclear engineers and scientists. Part 1. Basic statistical inference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beggs, W.J.

1981-02-01

This report is intended for the use of engineers and scientists working in the nuclear industry, especially at the Bettis Atomic Power Laboratory. It serves as the basis for several Bettis in-house statistics courses. The objectives of the report are to introduce the reader to the language and concepts of statistics and to provide a basic set of techniques to apply to problems of the collection and analysis of data. Part 1 covers subjects of basic inference. The subjects include: descriptive statistics; probability; simple inference for normally distributed populations, and for non-normal populations as well; comparison of two populations; themore » analysis of variance; quality control procedures; and linear regression analysis.« less

Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks.

PubMed

Chen, Yun; Nielsen, Jens

2013-12-01

Bio-based production of chemical building blocks from renewable resources is an attractive alternative to petroleum-based platform chemicals. Metabolic pathway and strain engineering is the key element in constructing robust microbial chemical factories within the constraints of cost effective production. Here we discuss how the development of computational algorithms, novel modules and methods, omics-based techniques combined with modeling refinement are enabling reduction in development time and thus advance the field of industrial biotechnology. We further discuss how recent technological developments contribute to the development of novel cell factories for the production of the building block chemicals: adipic acid, succinic acid and 3-hydroxypropionic acid. Copyright © 2013 Elsevier Ltd. All rights reserved.

Industrial Partners in the Education of an Engineer

ERIC Educational Resources Information Center

Smith, Barnard E.

1973-01-01

Discusses the theory, operation, and practical problems encountered in conducting a professional program which emphasizes close contact with industrial engineers in engineering education. Indicates that the partnership program provides one means for firms to participate in educational activities while serving their own interests. (CC)

How to Teach Engineering and Industrial Design: a U.K. Experience.

ERIC Educational Resources Information Center

Sheldon, D. F.

1988-01-01

Explored are the possibilities of teaching engineering through a project approach. Discussed are the introduction, clashing cultures of industrial and engineering design, skills required of a designer, teaching approach to the total design activity, CAD/CAM experiences, and conclusions. (Author/YP)

Facilitation of University Technology Transfer Through a Cooperative Service-University-Industry Program.

DTIC Science & Technology

1997-02-01

through technology transfer centers for applied engineering training and consulting, and second, in assisting and expanding university technology...both the services and industry with an applied engineering program and the training for new engineers and researchers, (2) serve as an information

A New Enhanced Engineering Programme for Manufacturing Industries.

ERIC Educational Resources Information Center

Clark, C.; And Others

1985-01-01

Special Engineering Programmes (SEPs) were established in Great Britain to attract highly able students into engineering and to provide education/training to meet the needs of manufacturing industries. SEP philosophy and objectives, program structure, student selection, course assessment, and other areas are discussed. (JN)

Industrial & Manufacturing Engineering | Classification | College of

Science.gov Websites

Engineering(414)229-6597msahmed@uwm.eduEng & Math Sciences EMS W383 profile photo Dr. Onur AsanAdjunct Assistant ProfessorIndustrial & Manufacturing Engineeringoasan@mcw.eduEng & Math Sciences profile ChandlerAdjunct InstructorIndustrial & Manufacturing Engineeringchandlec@uwm.eduEng & Math Sciences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pendse, Hemant P.

Maine and its industries identified more efficient utilization of biomass as a critical economic development issue. In Phase I of this implementation project, a research team was assembled, research equipment was implemented and expertise was demonstrated in pyrolysis, hydrodeoxygenation of pyrolysis oils, catalyst synthesis and characterization, and reaction engineering. Phase II built upon the infrastructure to innovate reaction pathways and process engineering, and integrate new approaches for fuels and chemical production within pulp and paper and other industries within the state. This research cluster brought together chemists, engineers, physicists and students from the University of Maine, Bates College, and Bowdoinmore » College. The project developed collaborations with Oak Ridge National Laboratory and Brookhaven National Laboratory. The specific research projects within this proposal were of critical interest to the DoE - in particular the biomass program within EERE and the catalysis/chemical transformations program within BES. Scientific and Technical Merit highlights of this project included: (1) synthesis and physical characterization of novel size-selective catalyst/supports using engineered mesoporous (1-10 nm diameter pores) materials, (2) advances in fundamental knowledge of novel support/ metal catalyst systems tailored for pyrolysis oil upgrading, (3) a microcalorimetric sensing technique, (4) improved methods for pyrolysis oil characterization, (5) production and characterization of woody biomass-derived pyrolysis oils, (6) development of two new patented bio oil pathways: thermal deoxygenation (TDO) and formate assisted pyrolysis (FASP), and (7) technoeconomics of pyrolysis of Maine forest biomass. This research cluster has provided fundamental knowledge to enable and assess pathways to thermally convert biomass to hydrocarbon fuels and chemicals.« less

Recent advances and state-of-the-art strategies in strain and process engineering for biobutanol production by Clostridium acetobutylicum.

PubMed

Xue, Chuang; Zhao, Jingbo; Chen, Lijie; Yang, Shang-Tian; Bai, Fengwu

Butanol as an advanced biofuel has gained great attention due to its environmental benefits and superior properties compared to ethanol. However, the cost of biobutanol production via conventional acetone-butanol-ethanol (ABE) fermentation by Clostridium acetobutylicum is not economically competitive, which has hampered its industrial application. The strain performance and downstream process greatly impact the economics of biobutanol production. Although various engineered strains with carefully orchestrated metabolic and sporulation-specific pathways have been developed, none of them is ideal for industrial biobutanol production. For further strain improvement, it is necessary to develop advanced genome editing tools and a deep understanding of cellular functioning of genes in metabolic and regulatory pathways. Processes with integrated product recovery can increase fermentation productivity by continuously removing inhibitory products while generating butanol (ABE) in a concentrated solution. In this review, we provide an overview of recent advances in C. acetobutylicum strain engineering and process development focusing on in situ product recovery. With deep understanding of systematic cellular bioinformatics, the exploration of state-of-the-art genome editing tools such as CRISPR-Cas for targeted gene knock-out and knock-in would play a vital role in Clostridium cell engineering for biobutanol production. Developing advanced hybrid separation processes for in situ butanol recovery, which will be discussed with a detailed comparison of advantages and disadvantages of various recovery techniques, is also imperative to the economical development of biobutanol. Copyright © 2017 Elsevier Inc. All rights reserved.

Software Engineering Technology Infusion Within NASA

NASA Technical Reports Server (NTRS)

Zelkowitz, Marvin V.

1996-01-01

Abstract technology transfer is of crucial concern to both government and industry today. In this paper, several software engineering technologies used within NASA are studied, and the mechanisms, schedules, and efforts at transferring these technologies are investigated. The goals of this study are: 1) to understand the difference between technology transfer (the adoption of a new method by large segments of an industry) as an industry-wide phenomenon and the adoption of a new technology by an individual organization (called technology infusion); and 2) to see if software engineering technology transfer differs from other engineering disciplines. While there is great interest today in developing technology transfer models for industry, it is the technology infusion process that actually causes changes in the current state of the practice.

Establishing a `Centre for Engineering Experimentation and Design Simulation': a step towards restructuring engineering education in India

NASA Astrophysics Data System (ADS)

Venkateswarlu, P.

2017-07-01

Reforms in undergraduate engineering curriculum to produce engineers with entrepreneurial skills should address real-world problems relevant to industry and society with active industry support. Technology-assisted, hands-on projects involving experimentation, design simulation and prototyping will transform graduates into professionals with necessary skills to create and advance knowledge that meets global standards. To achieve this goal, this paper proposes establishing a central facility, 'Centre for Engineering Experimentation and Design Simulation' (CEEDS) in autonomous engineering colleges in India. The centre will be equipped with the most recent technology resources and computational facilities where students execute novel interdisciplinary product-oriented projects benefiting both industry and society. Students undertake two projects: a short-term project aimed at an engineering solution to a problem in energy, health and environment and the other a major industry-supported project devoted to a product that enhances innovation and creativity. The paper presents the current status, the theoretical and pedagogical foundation for the centre's relevance, an activity plan and its implementation in the centre for product-based learning with illustrative examples.

[Comparison Analysis of Economic and Engineering Control of Industrial VOCs].

PubMed

Wang, Yu-fei; Liu, Chang-xin; Cheng, Jie; Hao, Zheng-ping; Wang, Zheng

2015-04-01

Volatile organic compounds (VOCs) pollutant has become China's major air pollutant in key urban areas like sulfur dioxide, nitrogen oxides and particulate matter. It is mainly produced from industry sectors, and engineering control is one of the most important reduction measures. During the 12th Five-Year Plan, China decides to invest 40 billion RMB to build pollution control projects in key industry sectors with annual emission reduction of 605 000 t x a(-1). It shows that China attaches a great importance to emission reduction by engineering projects and highlights the awareness of engineering reduction technologies. In this paper, a macroeconomic model, namely computable general equilibrium model, (CGE model) was employed to simulate engineering control and economic control (imposing environmental tax). We aim to compare the pros and cons of the two reduction policies. Considering the economic loss of the whole country, the environmental tax has more impacts on the economy system than engineering reduction measures. We suggest that the central government provides 7 500 RMB x t(-1) as subsidy for enterprises in industry sectors to encourage engineering reduction.

Establishment of an Undergraduate Research and Training Program in Radiochemistry at Florida Memorial University, a Historically Black College or University (HBCU)

NASA Astrophysics Data System (ADS)

Tamalis, Dimitri; Stiffin, Rose; Elliott, Michael; Huisso, Ayivi; Biegalski, Steven; Landsberger, Sheldon

2009-08-01

With the passing of the Energy Policy Act of 2005, the United States is experiencing for the first time in over two decades, what some refer to as the "Nuclear Renaissance". The US Nuclear Regulatory Commission (NRC) recognizes this surge in application submissions and is committed to reviewing these applications in a timely manner to support the country's growing energy demands. Notwithstanding these facts, it is understood that the nuclear industry requires appropriately trained and educated personnel to support the growing needs of the nuclear industry and the US NRC. Equally important is the need to educate the next generation of students in nuclear non-proliferation, nuclear forensics and various aspects of homeland security for the national laboratories and the Department of Defense. From mechanical engineers educated and experienced in materials, thermal/fluid dynamics, and component failure analysis, to physicists using advanced computing techniques to design the next generation of nuclear reactor fuel elements, the need for new engineers, scientists, and health physicist has never been greater.

Application of smart optical fiber sensors for structural load monitoring

NASA Astrophysics Data System (ADS)

Davies, Heddwyn; Everall, Lorna A.; Gallon, Andrew M.

2001-06-01

This paper describes a smart monitoring system, incorporating optical fiber sensing techniques, capable of providing important structural information to designers and users alike. This technology has wide industrial and commercial application in areas including aerospace, civil, maritime and automotive engineering. In order to demonstrate the capability of the sensing system it has been installed in a 35m free-standing carbon fiber yacht mast, where a complete optical network of strain and temperature sensors were embedded into a composite mast and boom during lay-up. The system was able to monitor the behavior of the composite rig through a range of handling conditions. The resulting strain information can be used by engineers to improve the structural design process. Embedded fiber optic sensors have wide ranging application for structural load monitoring. Due to their small size, optical fiber sensors can be readily embedded into composite materials. Other advantages include their immediate multiplexing capability and immunity to electro-magnetic interference. The capability of this system has been demonstrated within the maritime and industrial environment, but can be adapted for any application.

NASA Excellence Award for Quality and Productivity 1989 highlights. The 1989 recipient: Lockheed Engineering and Sciences Company

NASA Technical Reports Server (NTRS)

1990-01-01

The NASA Excellence Award for Productivity and Quality is the result of NASA's desire to encourage superior quality and the continuous improvement philosophy in the aerospace industry. It is awarded to NASA contractors, subcontractors, and suppliers who have demonstrated sustained excellence, customer orientation, and outstanding achievements in a total quality management (TQM) environment. The 'highlights' booklet is intended to transfer successful techniques demonstrated by the performance and quality of major NASA contractors.

Synthetic Defects for Vibrothermography

NASA Astrophysics Data System (ADS)

Renshaw, Jeremy; Holland, Stephen D.; Thompson, R. Bruce; Eisenmann, David J.

2010-02-01

Synthetic defects are an important tool used for characterizing the performance of nondestructive evaluation techniques. Viscous material-filled synthetic defects were developed for use in vibrothermography (also known as sonic IR) as a tool to improve inspection accuracy and reliability. This paper describes how the heat-generation response of these VMF synthetic defects is similar to the response of real defects. It also shows how VMF defects can be applied to improve inspection accuracy for complex industrial parts and presents a study of their application in an aircraft engine stator vane.

Hardfacing of duplex stainless steel using melting and diffusion processes

NASA Astrophysics Data System (ADS)

Lailatul, H.; Maleque, M. A.

2017-03-01

Duplex stainless steel (DSS) is a material with high potential successes in many new applications such as rail car manufacturing, automotive and chemical industries. Although DSS is widely used in various industries, this material has faced wear and hardness problems which obstruct a wider capability of this material and causes problems in current application. Therefore, development of surface modification has been introduced to produce hard protective layer or coating on DSS. The main aim of this work is to brief review on hard surface layer formation on DSS using melting and diffusion processes. Melting technique using tungsten inert gas (TIG) torch and diffusion technique using gas nitriding are the effective process to meet this requirement. The processing route plays a significant role in developing the hard surface layer for any application with effective cost and environmental factors. The good understanding and careful selection of processing route to form products are very important factors to decide the suitable techniques for surface engineering treatment. In this paper, an attempt is also made to consolidate the important research works done on melting and diffusion techniques of DSS in the past. The advantages and disadvantages between melting and diffusion technique are presented for better understanding on the feasibility of hard surface formation on DSS. Finally, it can be concluded that this work will open an avenue for further research on the application of suitable process for hard surface formation on DSS.

Biomedical engineering education through global engineering teams.

PubMed

Scheffer, C; Blanckenberg, M; Garth-Davis, B; Eisenberg, M

2012-01-01

Most industrial projects require a team of engineers from a variety of disciplines. The team members are often culturally diverse and geographically dispersed. Many students do not acquire sufficient skills from typical university courses to function efficiently in such an environment. The Global Engineering Teams (GET) programme was designed to prepare students such a scenario in industry. This paper discusses five biomedical engineering themed projects completed by GET students. The benefits and success of the programme in educating students in the field of biomedical engineering are discussed.

Introduction to the virtual special issue on super-resolution imaging techniques

NASA Astrophysics Data System (ADS)

Cao, Liangcai; Liu, Zhengjun

2017-12-01

Until quite recently, the resolution of optical imaging instruments, including telescopes, cameras and microscopes, was considered to be limited by the diffraction of light and by image sensors. In the past few years, many exciting super-resolution approaches have emerged that demonstrate intriguing ways to bypass the classical limit in optics and detectors. More and more research groups are engaged in the study of advanced super-resolution schemes, devices, algorithms, systems, and applications [1-6]. Super-resolution techniques involve new methods in science and engineering of optics [7,8], measurements [9,10], chemistry [11,12] and information [13,14]. Promising applications, particularly in biomedical research and semiconductor industry, have been successfully demonstrated.

Closing the gap in systems engineering education for the space industry

NASA Technical Reports Server (NTRS)

Carlisle, R.

1986-01-01

The education of system engineers with emphasis on designing systems for space applications is discussed. System engineers determine the functional requirements, performance needs, and implementation procedures for proposed systems and their education is based on aeronautics and mathematics. Recommendations from industry for improving the curriculum of system engineers at the undergraduate and graduate levels are provided. The assistance provided by companies to the education of system engineers is examined.

48 CFR 206.302-3 - Industrial mobilization, engineering, developmental, or research capability, or expert services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Industrial mobilization, engineering, developmental, or research capability, or expert services. 206.302-3 Section 206.302-3 Federal..., engineering, developmental, or research capability, or expert services. ...

48 CFR 206.302-3 - Industrial mobilization, engineering, developmental, or research capability, or expert services.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Industrial mobilization, engineering, developmental, or research capability, or expert services. 206.302-3 Section 206.302-3 Federal..., engineering, developmental, or research capability, or expert services. ...

Facilitation of University Technology Transfer through a Cooperative Army-University-Industry Program,

DTIC Science & Technology

1995-01-01

through Army technology transfer centers for applied engineering training and consulting, and second in assisting and expanding university technology...industry with an applied engineering program and the training for new engineers and researchers, serve as an information resource for both the Army and

Design approach of an aquaculture cage system for deployment in the constructed channel flow environments of a power plant

PubMed Central

Lee, Jihoon; Fredriksson, David W.; DeCew, Judson; Drach, Andrew; Yim, Solomon C.

2018-01-01

This study provides an engineering approach for designing an aquaculture cage system for use in constructed channel flow environments. As sustainable aquaculture has grown globally, many novel techniques have been introduced such as those implemented in the global Atlantic salmon industry. The advent of several highly sophisticated analysis software systems enables the development of such novel engineering techniques. These software systems commonly include three-dimensional (3D) drafting, computational fluid dynamics, and finite element analysis. In this study, a combination of these analysis tools is applied to evaluate a conceptual aquaculture system for potential deployment in a power plant effluent channel. The channel is supposedly clean; however, it includes elevated water temperatures and strong currents. The first portion of the analysis includes the design of a fish cage system with specific net solidities using 3D drafting techniques. Computational fluid dynamics is then applied to evaluate the flow reduction through the system from the previously generated solid models. Implementing the same solid models, a finite element analysis is performed on the critical components to assess the material stresses produced by the drag force loads that are calculated from the fluid velocities. PMID:29897954

Preliminary design of the redundant software experiment

NASA Technical Reports Server (NTRS)

Campbell, Roy; Deimel, Lionel; Eckhardt, Dave, Jr.; Kelly, John; Knight, John; Lauterbach, Linda; Lee, Larry; Mcallister, Dave; Mchugh, John

1985-01-01

The goal of the present experiment is to characterize the fault distributions of highly reliable software replicates, constructed using techniques and environments which are similar to those used in comtemporary industrial software facilities. The fault distributions and their effect on the reliability of fault tolerant configurations of the software will be determined through extensive life testing of the replicates against carefully constructed randomly generated test data. Each detected error will be carefully analyzed to provide insight in to their nature and cause. A direct objective is to develop techniques for reducing the intensity of coincident errors, thus increasing the reliability gain which can be achieved with fault tolerance. Data on the reliability gains realized, and the cost of the fault tolerant configurations can be used to design a companion experiment to determine the cost effectiveness of the fault tolerant strategy. Finally, the data and analysis produced by this experiment will be valuable to the software engineering community as a whole because it will provide a useful insight into the nature and cause of hard to find, subtle faults which escape standard software engineering validation techniques and thus persist far into the software life cycle.

77 FR 16769 - Energy Conservation Program for Certain Industrial Equipment: Energy Conservation Standards and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-22

... Conservation Program for Certain Industrial Equipment: Energy Conservation Standards and Test Procedures for...-Conditioning Engineers (ASHRAE)/Illuminating Engineering Society of North America (IESNA) Standard 90.1-2010... Industrial Equipment, which includes the commercial heating, air-conditioning, and water-heating equipment...

A Hybrid Neural Network Model for Sales Forecasting Based on ARIMA and Search Popularity of Article Titles.

PubMed

Omar, Hani; Hoang, Van Hai; Liu, Duen-Ren

2016-01-01

Enhancing sales and operations planning through forecasting analysis and business intelligence is demanded in many industries and enterprises. Publishing industries usually pick attractive titles and headlines for their stories to increase sales, since popular article titles and headlines can attract readers to buy magazines. In this paper, information retrieval techniques are adopted to extract words from article titles. The popularity measures of article titles are then analyzed by using the search indexes obtained from Google search engine. Backpropagation Neural Networks (BPNNs) have successfully been used to develop prediction models for sales forecasting. In this study, we propose a novel hybrid neural network model for sales forecasting based on the prediction result of time series forecasting and the popularity of article titles. The proposed model uses the historical sales data, popularity of article titles, and the prediction result of a time series, Autoregressive Integrated Moving Average (ARIMA) forecasting method to learn a BPNN-based forecasting model. Our proposed forecasting model is experimentally evaluated by comparing with conventional sales prediction techniques. The experimental result shows that our proposed forecasting method outperforms conventional techniques which do not consider the popularity of title words.

A Hybrid Neural Network Model for Sales Forecasting Based on ARIMA and Search Popularity of Article Titles

PubMed Central

Omar, Hani; Hoang, Van Hai; Liu, Duen-Ren

2016-01-01

Enhancing sales and operations planning through forecasting analysis and business intelligence is demanded in many industries and enterprises. Publishing industries usually pick attractive titles and headlines for their stories to increase sales, since popular article titles and headlines can attract readers to buy magazines. In this paper, information retrieval techniques are adopted to extract words from article titles. The popularity measures of article titles are then analyzed by using the search indexes obtained from Google search engine. Backpropagation Neural Networks (BPNNs) have successfully been used to develop prediction models for sales forecasting. In this study, we propose a novel hybrid neural network model for sales forecasting based on the prediction result of time series forecasting and the popularity of article titles. The proposed model uses the historical sales data, popularity of article titles, and the prediction result of a time series, Autoregressive Integrated Moving Average (ARIMA) forecasting method to learn a BPNN-based forecasting model. Our proposed forecasting model is experimentally evaluated by comparing with conventional sales prediction techniques. The experimental result shows that our proposed forecasting method outperforms conventional techniques which do not consider the popularity of title words. PMID:27313605

Investigating the probability of detection of typical cavity shapes through modelling and comparison of geophysical techniques

NASA Astrophysics Data System (ADS)

James, P.

2011-12-01

With a growing need for housing in the U.K., the government has proposed increased development of brownfield sites. However, old mine workings and natural cavities represent a potential hazard before, during and after construction on such sites, and add further complication to subsurface parameters. Cavities are hence a limitation to certain redevelopment and their detection is an ever important consideration. The current standard technique for cavity detection is a borehole grid, which is intrusive, non-continuous, slow and expensive. A new robust investigation standard in the detection of cavities is sought and geophysical techniques offer an attractive alternative. Geophysical techniques have previously been utilised successfully in the detection of cavities in various geologies, but still has an uncertain reputation in the engineering industry. Engineers are unsure of the techniques and are inclined to rely on well known techniques than utilise new technologies. Bad experiences with geophysics are commonly due to the indiscriminate choice of particular techniques. It is imperative that a geophysical survey is designed with the specific site and target in mind at all times, and the ability and judgement to rule out some, or all, techniques. To this author's knowledge no comparative software exists to aid technique choice. Also, previous modelling software limit the shapes of bodies and hence typical cavity shapes are not represented. Here, we introduce 3D modelling software (Matlab) which computes and compares the response to various cavity targets from a range of techniques (gravity, gravity gradient, magnetic, magnetic gradient and GPR). Typical near surface cavity shapes are modelled including shafts, bellpits, various lining and capping materials, and migrating voids. The probability of cavity detection is assessed in typical subsurface and noise conditions across a range of survey parameters. Techniques can be compared and the limits of detection distance assessed. The density of survey points required to achieve a required probability of detection can be calculated. The software aids discriminate choice of technique, improves survey design, and increases the likelihood of survey success; all factors sought in the engineering industry. As a simple example, the response from magnetometry, gravimetry, and gravity gradient techniques above an example 3m deep, 1m cube air cavity in limestone across a 15m grid was calculated. The maximum responses above the cavity are small (amplitudes of 0.018nT, 0.0013mGal, 8.3eotvos respectively), but at typical site noise levels the detection reliability is over 50% for the gradient gravity method on a single survey line. Increasing the number of survey points across the site increases the reliability of detection of the anomaly by the addition of probabilities. We can calculate the probability of detection at different profile spacings to assess the best possible survey design. At 1m spacing the overall probability of by the gradient gravity method is over 90%, and over 60% for magnetometry (at 3m spacing the probability drops to 32%). The use of modelling in near surface surveys is a useful tool to assess the feasibility of a range of techniques to detect subtle signals. Future work will integrate this work with borehole measured parameters.

Affordable Development and Demonstration of a Small NTR Engine and Stage: A Preliminary NASA, DOE, and Industry Assessment

NASA Technical Reports Server (NTRS)

Borowski, Stanley K.; Sefcik, Robert J.; Fittje, James E.; McCurdy, David R.; Qualls, Arthur L.; Schnitzler, Bruce G.; Werner, James E.; Weitzberg, Abraham; Joyner, Claude R.

2015-01-01

The Nuclear Thermal Rocket (NTR) represents the next evolutionary step in cryogenic liquid rocket engines. Deriving its energy from fission of uranium-235 atoms contained within fuel elements that comprise the engine's reactor core, the NTR can generate high thrust at a specific impulse of approx. 900 seconds or more - twice that of today's best chemical rockets. In FY'11, as part of the AISP project, NASA proposed a Nuclear Thermal Propulsion (NTP) effort that envisioned two key activities - "Foundational Technology Development" followed by system-level "Technology Demonstrations". Five near-term NTP activities identified for Foundational Technology Development became the basis for the NCPS project started in FY'12 and funded by NASA's AES program. During Phase 1 (FY'12-14), the NCPS project was focused on (1) Recapturing fuel processing techniques and fabricating partial length "heritage" fuel elements for the two candidate fuel forms identified by NASA and the DOE - NERVA graphite "composite" and the uranium dioxide (UO2) in tungsten "cermet". The Phase 1 effort also included: (2) Engine Conceptual Design; (3) Mission Analysis and Requirements Definition; (4) Identification of Affordable Options for Ground Testing; and (5) Formulation of an Affordable and Sustainable NTP Development Strategy. During FY'14, a preliminary plan for DDT&E was outlined by GRC, the DOE and industry for NASA HQ that involved significant system-level demonstration projects that included GTD tests at the NNSS, followed by a FTD mission. To reduce development costs, the GTD and FTD tests use a small, low thrust (approx. 7.5 or 16.5 klbf) engine. Both engines use graphite composite fuel and a "common" fuel element design that is scalable to higher thrust (approx. 25 klbf) engines by increasing the number of elements in a larger diameter core that can produce greater thermal power output. To keep the FTD mission cost down, a simple "1-burn" lunar flyby mission was considered along with maximizing the use of existing and flight proven liquid rocket and stage hardware (e.g., from the RL10-B2 engine and Delta Cryogenic Second Stage) to further ensure affordability. This paper provides a preliminary NASA, DOE and industry assessment of what is required - the key DDT&E activities, development options, and the associated schedule - to affordably build, ground test and fly a small NTR engine and stage within a 10-year timeframe.

Vibration isolation of automotive vehicle engine using periodic mounting systems

NASA Astrophysics Data System (ADS)

Asiri, S.

2005-05-01

Customer awareness and sensitivity to noise and vibration levels have been raised through increasing television advertisement, in which the vehicle noise and vibration performance is used as the main market differentiation. This awareness has caused the transportation industry to regard noise and vibration as important criteria for improving market shares. One industry that tends to be in the forefront of the technology to reduce the levels of noise and vibration is the automobile industry. Hence, it is of practical interest to reduce the vibrations induced structural responses. The automotive vehicle engine is the main source of mechanical vibrations of automobiles. The engine is vulnerable to the dynamic action caused by engine disturbance force in various speed ranges. The vibrations of the automotive vehicle engines may cause structural failure, malfunction of other parts, or discomfort to passengers because of high level noise and vibrations. The mounts of the engines act as the transmission paths of the vibrations transmitted from the excitation sources to the body of the vehicle and passengers. Therefore, proper design and control of these mounts are essential to the attenuation of the vibration of platform structures. To improve vibration resistant capacities of engine mounting systems, vibration control techniques may be used. For instance, some passive and semi-active dissipation devices may be installed at mounts to enhance vibration energy absorbing capacity. In the proposed study, a radically different concept is presented whereby periodic mounts are considered because these mounts exhibit unique dynamic characteristics that make them act as mechanical filters for wave propagation. As a result, waves can propagate along the periodic mounts only within specific frequency bands called the "Pass Bands" and wave propagation is completely blocked within other frequency bands called the "Stop Bands". The experimental arrangements, including the design of mounting systems with plain and periodic mounts will be studied first. The dynamic characteristics of such systems will be obtained experimentally in both cases. The tests will be then carried out to study the performance characteristics of periodic mounts with geometrical and/or material periodicity. The effectiveness of the periodicity on the vibration levels of mounting systems will be demonstrated theoretically and experimentally. Finally, the experimental results will be compared with the theoretical predictions.

Development and Hotfire Testing of Additively Manufactured Copper Combustion Chambers for Liquid Rocket Engine Applications

NASA Technical Reports Server (NTRS)

Gradl, Paul R.; Greene, Sandy; Protz, Chris

2017-01-01

NASA and industry partners are working towards fabrication process development to reduce costs and schedules associated with manufacturing liquid rocket engine components with the goal of reducing overall mission costs. One such technique being evaluated is powder-bed fusion or selective laser melting (SLM), commonly referred to as additive manufacturing (AM). The NASA Low Cost Upper Stage Propulsion (LCUSP) program was designed to develop processes and material characterization for GRCop-84 (a NASA Glenn Research Center-developed copper, chrome, niobium alloy) commensurate with powder bed AM, evaluate bimetallic deposition, and complete testing of a full scale combustion chamber. As part of this development, the process has been transferred to industry partners to enable a long-term supply chain of monolithic copper combustion chambers. To advance the processes further and allow for optimization with multiple materials, NASA is also investigating the feasibility of bimetallic AM chambers. In addition to the LCUSP program, NASA’s Marshall Space Flight Center (MSFC) has completed a series of development programs and hot-fire tests to demonstrate SLM GRCop-84 and other AM techniques. MSFC’s efforts include a 4,000 pounds-force thrust liquid oxygen/methane (LOX/CH4) combustion chamber. Small thrust chambers for 1,200 pounds-force LOX/hydrogen (H2) applications have also been designed and fabricated with SLM GRCop-84. Similar chambers have also completed development with an Inconel 625 jacket bonded to the GRCop-84 material, evaluating direct metal deposition (DMD) laser- and arc-based techniques. The same technologies for these lower thrust applications are being applied to 25,000-35,000 pounds-force main combustion chamber (MCC) designs. This paper describes the design, development, manufacturing and testing of these numerous combustion chambers, and the associated lessons learned throughout their design and development processes.

Introduction of Sustainability Concepts into Industrial Engineering Education: A Modular Approach

ERIC Educational Resources Information Center

Nazzal, Dima; Zabinski, Joseph; Hugar, Alexander; Reinhart, Debra; Karwowski, Waldemar; Madani, Kaveh

2015-01-01

Sustainability in operations, production, and consumption continues to gain relevance for engineers. This trend will accelerate as demand for goods and services grows, straining resources and requiring ingenuity to replace boundless supply in meeting the needs of a more crowded, more prosperous world. Industrial engineers are uniquely positioned…

Engineered CRISPR/Cas9 system for multiplex genome engineering of polyploid industrial yeast strains

DOE PAGES

Lian, Jiazhang; Bao, Zehua; Hu, Sumeng; ...

2018-02-20

The CRISPR/Cas9 system has been widely used for multiplex genome engineering of Saccharomyces cerevisiae. Furthermore, its application in manipulating industrial yeast strains is less successful, probably due to the genome complexity and low copy numbers of gRNA expression plasmids. Here we developed an efficient CRISPR/Cas9 system for industrial yeast strain engineering by using our previously engineered plasmids with increased copy numbers. Four genes in both a diploid strain (Ethanol Red, 8 alleles in total) and a triploid strain (ATCC 4124, 12 alleles in total) were knocked out in a single step with 100% efficiency. This system was used to constructmore » xylose-fermenting, lactate-producing industrial yeast strains, in which ALD6, PHO13, LEU2, and URA3 were disrupted in a single step followed by the introduction of a xylose utilization pathway and a lactate biosynthetic pathway on auxotrophic marker plasmids. The optimized CRISPR/Cas9 system provides a powerful tool for the development of industrial yeast based microbial cell factories.« less

Engineered CRISPR/Cas9 system for multiplex genome engineering of polyploid industrial yeast strains

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lian, Jiazhang; Bao, Zehua; Hu, Sumeng

The CRISPR/Cas9 system has been widely used for multiplex genome engineering of Saccharomyces cerevisiae. Furthermore, its application in manipulating industrial yeast strains is less successful, probably due to the genome complexity and low copy numbers of gRNA expression plasmids. Here we developed an efficient CRISPR/Cas9 system for industrial yeast strain engineering by using our previously engineered plasmids with increased copy numbers. Four genes in both a diploid strain (Ethanol Red, 8 alleles in total) and a triploid strain (ATCC 4124, 12 alleles in total) were knocked out in a single step with 100% efficiency. This system was used to constructmore » xylose-fermenting, lactate-producing industrial yeast strains, in which ALD6, PHO13, LEU2, and URA3 were disrupted in a single step followed by the introduction of a xylose utilization pathway and a lactate biosynthetic pathway on auxotrophic marker plasmids. The optimized CRISPR/Cas9 system provides a powerful tool for the development of industrial yeast based microbial cell factories.« less

Engineered CRISPR/Cas9 system for multiplex genome engineering of polyploid industrial yeast strains.

PubMed

Lian, Jiazhang; Bao, Zehua; Hu, Sumeng; Zhao, Huimin

2018-06-01

The CRISPR/Cas9 system has been widely used for multiplex genome engineering of Saccharomyces cerevisiae. However, its application in manipulating industrial yeast strains is less successful, probably due to the genome complexity and low copy numbers of gRNA expression plasmids. Here we developed an efficient CRISPR/Cas9 system for industrial yeast strain engineering by using our previously engineered plasmids with increased copy numbers. Four genes in both a diploid strain (Ethanol Red, 8 alleles in total) and a triploid strain (ATCC 4124, 12 alleles in total) were knocked out in a single step with 100% efficiency. This system was used to construct xylose-fermenting, lactate-producing industrial yeast strains, in which ALD6, PHO13, LEU2, and URA3 were disrupted in a single step followed by the introduction of a xylose utilization pathway and a lactate biosynthetic pathway on auxotrophic marker plasmids. The optimized CRISPR/Cas9 system provides a powerful tool for the development of industrial yeast based microbial cell factories. © 2018 Wiley Periodicals, Inc.

Progress in industrial holography in France

NASA Astrophysics Data System (ADS)

Smigielski, Paul

1992-01-01

Industrial applications of holography in France are briefly reviewed. Particular attention is given to nondestructive testing of helicopter blades at Aerospatiale Central Laboratory, the use of holography at Renault for car-engine vibration study, vibration characterization of turbo-jet engine components at SNECMA, and vibration analysis of plates in an industrial hemodynamic tunnel.

Engineering industrial Saccharomyces cerevisiae strains for xylose fermentation and comparison for switchgrass conversion

USDA-ARS?s Scientific Manuscript database

Saccharomyces physiology and fermentation related properties vary broadly among industrial strains. In this study, six industrial strains of varied genetic background were engineered to ferment xylose. Aerobic growth rates on xylose were 0.040 h**-1 to 0.167 h**-1. Fermentation of xylose, glucose/xy...

Research and Development in Industry: 1979. Funds, 1979. Scientists and Engineers, January 1980. Surveys of Science Resources Series. Final Report.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC.

This report analyzes data on research and development (R&D) performed by industry during 1979, examines historical trends for key R&D funding variables, and presents information on industry-employed R&D scientists and engineers. Areas addressed in the first section on R&D funds include: major R&D industries (aircraft/missiles,…

Flow of natural versus economic capital in industrial supply networks and its implications to sustainability.

PubMed

Ukidwe, Nandan U; Bakshi, Bhavik R

2005-12-15

Appreciating the reliance of industrial networks on natural capital is a necessary step toward their sustainable design and operation. However, most contemporary accounting techniques, including engineering economics, life cycle assessment, and full cost accounting, fail in this regard, as they take natural capital for granted and concentrate mainly on the economic aspects and emissions. The recently developed "thermodynamic input-output analysis" (TIOA) includes the contribution of ecological goods, ecosystem services, human resources, and impact of emissions in an economic input-output model. This paper uses TIOA to determine the throughputs of natural and economic capitals along industrial supply networks. The ratios of natural to economic capitals of economic sectors reveals a hierarchical organization of the U.S. economy wherein basic infrastructure industries are at the bottom and specialized value-added industries constitute the top. These results provide novel insight into the reliance of specific industrial sectors and supply chains on natural capital and the corresponding economic throughput. Such insight is useful for understanding the implications of corporate restructuring on industrial sustainability metrics and of outsourcing of business activities on outsourcer, outsourcee, and global sustainability. These implications are discussed from the standpoints of weak and strong sustainability paradigms. The calculated ratios can also be used for hybrid thermodynamic life cycle assessment.

Should bioengineering graduates seek employment in the defense industry?

PubMed

Johnson, Arthur T

2014-01-01

They say that the difference between a mechanical engineer and a civil engineer is that the mechanical engineer develops weapons whereas a civil engineer designs targets. The implication is that some engineers are involved with building peaceful infrastructure whereas others contribute to destruction. This brings to mind the question: what is the proper role for engineers in the creation of weapons and defenses against them? In particular, should engineers specializing in biology or medicine be involved in the defense industry? After all, bioengineers are supposed to be builders or healers rather than warriors or destroyers.

Systems metabolic engineering in an industrial setting.

PubMed

Sagt, Cees M J

2013-03-01

Systems metabolic engineering is based on systems biology, synthetic biology, and evolutionary engineering and is now also applied in industry. Industrial use of systems metabolic engineering focuses on strain and process optimization. Since ambitious yields, titers, productivities, and low costs are key in an industrial setting, the use of effective and robust methods in systems metabolic engineering is becoming very important. Major improvements in the field of proteomics and metabolomics have been crucial in the development of genome-wide approaches in strain and process development. This is accompanied by a rapid increase in DNA sequencing and synthesis capacity. These developments enable the use of systems metabolic engineering in an industrial setting. Industrial systems metabolic engineering can be defined as the combined use of genome-wide genomics, transcriptomics, proteomics, and metabolomics to modify strains or processes. This approach has become very common since the technology for generating large data sets of all levels of the cellular processes has developed quite fast into robust, reliable, and affordable methods. The main challenge and scope of this mini review is how to translate these large data sets in relevant biological leads which can be tested for strain or process improvements. Experimental setup, heterogeneity of the culture, and sample pretreatment are important issues which are easily underrated. In addition, the process of structuring, filtering, and visualization of data is important, but also, the availability of a genetic toolbox and equipment for medium/high-throughput fermentation is a key success factor. For an efficient bioprocess, all the different components in this process have to work together. Therefore, mutual tuning of these components is an important strategy.

Patterning via optical saturable transitions

NASA Astrophysics Data System (ADS)

Cantu, Precious

For the past 40 years, optical lithography has been the patterning workhorse for the semiconductor industry. However, as integrated circuits have become more and more complex, and as device geometries shrink, more innovative methods are required to meet these needs. In the far-field, the smallest feature that can be generated with light is limited to approximately half the wavelength. This, so called far-field diffraction limit or the Abbe limit (after Prof. Ernst Abbe who first recognized this), effectively prevents the use of long-wavelength photons >300nm from patterning nanostructures <100nm. Even with a 193nm laser source and extremely complicated processing, patterns below ˜20nm are incredibly challenging to create. Sources with even shorter wavelengths can potentially be used. However, these tend be much more expensive and of much lower brightness, which in turn limits their patterning speed. Multi-photon reactions have been proposed to overcome the diffraction limit. However, these require very large intensities for modest gain in resolution. Moreover, the large intensities make it difficult to parallelize, thus limiting the patterning speed. In this dissertation, a novel nanopatterning technique using wavelength-selective small molecules that undergo single-photon reactions, enabling rapid top-down nanopatterning over large areas at low-light intensities, thereby allowing for the circumvention of the far-field diffraction barrier is developed and experimentally verified. This approach, which I refer to as Patterning via Optical Saturable Transitions (POST) has the potential for massive parallelism, enabling the creation of nanostructures and devices at a speed far surpassing what is currently possible with conventional optical lithographic techniques. The fundamental understanding of this technique goes beyond optical lithography in the semiconductor industry and is applicable to any area that requires the rapid patterning of large-area two or three-dimensional complex geometries. At a basic level, this research intertwines the fields of electrochemistry, material science, electrical engineering, optics, physics, and mechanical engineering with the goal of developing a novel super-resolution lithographic technique.

Design and development of the Waukesha Custom Engine Control Air/Fuel Module

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moss, D.W.

1996-12-31

The Waukesha Custom Engine Control Air/Fuel Module (AFM) is designed to control the air-fuel ratio for all Waukesha carbureted, gaseous fueled, industrial engine. The AFM is programmed with a personal computer to run in one of four control modes: catalyst, best power, best economy, or lean-burn. One system can control naturally aspirated, turbocharged, in-line or vee engines. The basic system consists of an oxygen sensing system, intake manifold pressure transducer, electronic control module, actuator and exhaust thermocouple. The system permits correct operation of Waukesha engines in spite of changes in fuel pressure or temperature, engine load or speed, and fuelmore » composition. The system utilizes closed loop control and is centered about oxygen sensing technology. An innovative approach to applying oxygen sensors to industrial engines provides very good performance, greatly prolongs sensor life, and maintains sensor accuracy. Design considerations and operating results are given for application of the system to stationary, industrial engines operating on fuel gases of greatly varying composition.« less

Transfer printing techniques for materials assembly and micro/nanodevice fabrication.

PubMed

Carlson, Andrew; Bowen, Audrey M; Huang, Yonggang; Nuzzo, Ralph G; Rogers, John A

2012-10-09

Transfer printing represents a set of techniques for deterministic assembly of micro-and nanomaterials into spatially organized, functional arrangements with two and three-dimensional layouts. Such processes provide versatile routes not only to test structures and vehicles for scientific studies but also to high-performance, heterogeneously integrated functional systems, including those in flexible electronics, three-dimensional and/or curvilinear optoelectronics, and bio-integrated sensing and therapeutic devices. This article summarizes recent advances in a variety of transfer printing techniques, ranging from the mechanics and materials aspects that govern their operation to engineering features of their use in systems with varying levels of complexity. A concluding section presents perspectives on opportunities for basic and applied research, and on emerging use of these methods in high throughput, industrial-scale manufacturing. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Software Past, Present, and Future: Views from Government, Industry and Academia

NASA Technical Reports Server (NTRS)

Holcomb, Lee; Page, Jerry; Evangelist, Michael

2000-01-01

Views from the NASA CIO NASA Software Engineering Workshop on software development from the past, present, and future are presented. The topics include: 1) Software Past; 2) Software Present; 3) NASA's Largest Software Challenges; 4) 8330 Software Projects in Industry Standish Groups 1994 Report; 5) Software Future; 6) Capability Maturity Model (CMM): Software Engineering Institute (SEI) levels; 7) System Engineering Quality Also Part of the Problem; 8) University Environment Trends Will Increase the Problem in Software Engineering; and 9) NASA Software Engineering Goals.

Labor Market Slackens for New Science and Engineering Graduates. Science Resources Studies Highlights.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

Recent recruiting experiences of firms that employ scientific and engineering (S/E) personnel were determined in a followup to a 1981 survey. The following industries, which employ almost three-fourths of the scientists and engineers in private industry, were included in the survey: mining, construction, petroleum refining and extraction,…

Predictors of Effective Leadership in Industry--Should Engineering Education Focus on Traditional Intelligence, Personality, or Emotional Intelligence?

ERIC Educational Resources Information Center

Lappalainen, Pia

2015-01-01

Despite the changing global and industrial conditions requiring new approaches to leadership, management training as part of higher engineering education still remains understudied. The subsequent gap in engineering education calls for research on today's leader requirements and pedagogy supporting the inclusion of management competence in higher…

Small Engine Manufacturing in Wisconsin: Work Reorganization and Training Needs.

ERIC Educational Resources Information Center

Wisconsin Univ., Madison. Center on Wisconsin Strategy.

Wisconsin is the country's leading manufacturer of small engines, and the network of companies and suppliers constituting the small engine industry accounts for more than 5% of the state's entire manufacturing base. For the past 15 years, the industry has been rocked by intensified international competition and rapid technological advancement. A…

Utilization of and Demand for Engineers and Scientists in Industrial Research.

ERIC Educational Resources Information Center

Alden, John D.

A survey of the employment and demand for scientists and engineers in industrial research laboratories was made among all companies belonging to the Industrial Research Institute and a number of other organizations early in 1972. A questionnaire was used to analyze such aspects as reliability of future estimates, employment trends, personnel…

An industrial engineering approach to laboratory automation for high throughput screening

PubMed Central

Menke, Karl C.

2000-01-01

Across the pharmaceutical industry, there are a variety of approaches to laboratory automation for high throughput screening. At Sphinx Pharmaceuticals, the principles of industrial engineering have been applied to systematically identify and develop those automated solutions that provide the greatest value to the scientists engaged in lead generation. PMID:18924701

Murjottelu-Interdisciplinary Training Campaign for Industrial Design and Engineering Students

ERIC Educational Resources Information Center

Itkonen, Maija; Ekman, Kalevi Edvard; Kojo, Inka

2009-01-01

Today's growing business competition demands that design and technology must be seamlessly integrated. Designers should be employed increasingly as in-house in the industry, in addition to entrepreneurship and consultancy employment. How to realise this aim? Industry training is a tradition in engineering studies, but that is rarely the case in…

Technology Education; Engineering Technology and Industrial Technology in California Community Colleges: A Curriculum Guide.

ERIC Educational Resources Information Center

Schon, James F.

In order to identify the distinguishing characteristics of technical education programs in engineering and industrial technology currently offered by post-secondary institutions in California, a body of data was collected by visiting 25 community colleges, 5 state universities, and 8 industrial firms; by a questionnaire sampling of 72 California…

The Importance of Industrial Ecology in Engineering Education for Sustainable Development

ERIC Educational Resources Information Center

Biswas, Wahidul K.

2012-01-01

Purpose: The purpose of this paper is to show how industrial ecology can facilitate the achievement of sustainable development through its incorporation into an engineering curriculum. Design/methodology/approach: A model has been developed for assessing sustainability learning outcomes due to the incorporation of the concept of industrial ecology…

Industrial Engineering Lifts Off at Kennedy Space Center

NASA Technical Reports Server (NTRS)

Barth, Tim

1998-01-01

When the National Aeronautics and Space Administration (NASA) began the Space Shuttle Program, it did not have an established industrial engineering (IE) capability for several probable reasons. For example, it was easy for some managers to dismiss IE principles as being inapplicable at NASA's John F. Kennedy Space Center (KSC). When NASA was formed by the National Aeronautics and Space Act of 1958, most industrial engineers worked in more traditional factory environments. The primary emphasis early in the shuttle program, and during previous human space flight programs such as Mercury and Apollo, was on technical accomplishments. Industrial engineering is sometimes difficult to explain in NASA's highly technical culture. IE is different in many ways from other engineering disciplines because it is devoted to process management and improvement, rather than product design. Images of clipboards and stopwatches still come to the minds of many people when the term industrial engineering is mentioned. The discipline of IE has only recently begun to gain acceptance and understanding in NASA. From an IE perspective today, the facilities used for flight hardware processing at KSC are NASA's premier factories. The products of these factories are among the most spectacular in the world: safe and successful launches of shuttles and expendable vehicles that carry tremendous payloads into space.

A Recommended Framework for the Network-Centric Acquisition Process

DTIC Science & Technology

2009-09-01

ISO /IEC 12207 , Systems and Software Engineering-Software Life-Cycle Processes  ANSI/EIA 632, Processes for Engineering a System. There are...engineering [46]. Some of the process models presented in the DAG are:  ISO /IEC 15288, Systems and Software Engineering-System Life-Cycle Processes...e.g., ISO , IA, Security, etc.). Vetting developers helps ensure that they are using industry best industry practices and maximize the IA compliance

Industrial biosystems engineering and biorefinery systems.

PubMed

Chen, Shulin

2008-06-01

The concept of Industrial Biosystems Engineering (IBsE) was suggested as a new engineering branch to be developed for meeting the needs for science, technology and professionals by the upcoming bioeconomy. With emphasis on systems, IBsE builds upon the interfaces between systems biology, bioprocessing, and systems engineering. This paper discussed the background, the suggested definition, the theoretical framework and methodologies of this new discipline as well as its challenges and future development.

A continuous latitudinal energy balance model to explore non-uniform climate engineering strategies

NASA Astrophysics Data System (ADS)

Bonetti, F.; McInnes, C. R.

2016-12-01

Current concentrations of atmospheric CO2 exceed measured historical levels in modern times, largely attributed to anthropogenic forcing since the industrial revolution. The required decline in emissions rates has never been achieved leading to recent interest in climate engineering for future risk-mitigation strategies. Climate engineering aims to offset human-driven climate change. It involves techniques developed both to reduce the concentration of CO2 in the atmosphere (Carbon Dioxide Removal (CDR) methods) and to counteract the radiative forcing that it generates (Solar Radiation Management (SRM) methods). In order to investigate effects of SRM technologies for climate engineering, an analytical model describing the main dynamics of the Earth's climate has been developed. The model is a time-dependent Energy Balance Model (EBM) with latitudinal resolution and allows for the evaluation of non-uniform climate engineering strategies. A significant disadvantage of climate engineering techniques involving the management of solar radiation is regional disparities in cooling. This model offers an analytical approach to design multi-objective strategies that counteract climate change on a regional basis: for example, to cool the Artic and restrict undesired impacts at mid-latitudes, or to control the equator-to-pole temperature gradient. Using the Green's function approach the resulting partial differential equation allows for the computation of the surface temperature as a function of time and latitude when a 1% per year increase in the CO2 concentration is considered. After the validation of the model through comparisons with high fidelity numerical models, it will be used to explore strategies for the injection of the aerosol precursors in the stratosphere. In particular, the model involves detailed description of the optical properties of the particles, the wash-out dynamics and the estimation of the radiative cooling they can generate.

Biomedical microfluidic devices by using low-cost fabrication techniques: A review.

PubMed

Faustino, Vera; Catarino, Susana O; Lima, Rui; Minas, Graça

2016-07-26

One of the most popular methods to fabricate biomedical microfluidic devices is by using a soft-lithography technique. However, the fabrication of the moulds to produce microfluidic devices, such as SU-8 moulds, usually requires a cleanroom environment that can be quite costly. Therefore, many efforts have been made to develop low-cost alternatives for the fabrication of microstructures, avoiding the use of cleanroom facilities. Recently, low-cost techniques without cleanroom facilities that feature aspect ratios more than 20, for fabricating those SU-8 moulds have been gaining popularity among biomedical research community. In those techniques, Ultraviolet (UV) exposure equipment, commonly used in the Printed Circuit Board (PCB) industry, replaces the more expensive and less available Mask Aligner that has been used in the last 15 years for SU-8 patterning. Alternatively, non-lithographic low-cost techniques, due to their ability for large-scale production, have increased the interest of the industrial and research community to develop simple, rapid and low-cost microfluidic structures. These alternative techniques include Print and Peel methods (PAP), laserjet, solid ink, cutting plotters or micromilling, that use equipment available in almost all laboratories and offices. An example is the xurography technique that uses a cutting plotter machine and adhesive vinyl films to generate the master moulds to fabricate microfluidic channels. In this review, we present a selection of the most recent lithographic and non-lithographic low-cost techniques to fabricate microfluidic structures, focused on the features and limitations of each technique. Only microfabrication methods that do not require the use of cleanrooms are considered. Additionally, potential applications of these microfluidic devices in biomedical engineering are presented with some illustrative examples. Copyright © 2015 Elsevier Ltd. All rights reserved.

Industrial Engineering Tool Use in Quality Improvement Projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodin, Wayne; Beruvides, Mario

This paper presents the results of an examination of industrial engineering tool use in Six Sigma projects for a contractor providing specialty manufacturing and service activities for a United States federal government agency.

46 CFR 58.60-11 - Analyses, plans, diagrams and specifications: Submission.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Industrial Systems and Components on Mobile...) Each industrial system must be analyzed by a registered professional engineer to certify that the...

46 CFR 58.60-11 - Analyses, plans, diagrams and specifications: Submission.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Industrial Systems and Components on Mobile...) Each industrial system must be analyzed by a registered professional engineer to certify that the...

46 CFR 58.60-11 - Analyses, plans, diagrams and specifications: Submission.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Industrial Systems and Components on Mobile...) Each industrial system must be analyzed by a registered professional engineer to certify that the...

46 CFR 58.60-11 - Analyses, plans, diagrams and specifications: Submission.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Industrial Systems and Components on Mobile...) Each industrial system must be analyzed by a registered professional engineer to certify that the...

46 CFR 58.60-11 - Analyses, plans, diagrams and specifications: Submission.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Industrial Systems and Components on Mobile...) Each industrial system must be analyzed by a registered professional engineer to certify that the...

Developing Learning Tool of Control System Engineering Using Matrix Laboratory Software Oriented on Industrial Needs

NASA Astrophysics Data System (ADS)

Isnur Haryudo, Subuh; Imam Agung, Achmad; Firmansyah, Rifqi

2018-04-01

The purpose of this research is to develop learning media of control technique using Matrix Laboratory software with industry requirement approach. Learning media serves as a tool for creating a better and effective teaching and learning situation because it can accelerate the learning process in order to enhance the quality of learning. Control Techniques using Matrix Laboratory software can enlarge the interest and attention of students, with real experience and can grow independent attitude. This research design refers to the use of research and development (R & D) methods that have been modified by multi-disciplinary team-based researchers. This research used Computer based learning method consisting of computer and Matrix Laboratory software which was integrated with props. Matrix Laboratory has the ability to visualize the theory and analysis of the Control System which is an integration of computing, visualization and programming which is easy to use. The result of this instructional media development is to use mathematical equations using Matrix Laboratory software on control system application with DC motor plant and PID (Proportional-Integral-Derivative). Considering that manufacturing in the field of Distributed Control systems (DCSs), Programmable Controllers (PLCs), and Microcontrollers (MCUs) use PID systems in production processes are widely used in industry.

Improving industrial yeast strains: exploiting natural and artificial diversity.

PubMed

Steensels, Jan; Snoek, Tim; Meersman, Esther; Picca Nicolino, Martina; Voordeckers, Karin; Verstrepen, Kevin J

2014-09-01

Yeasts have been used for thousands of years to make fermented foods and beverages, such as beer, wine, sake, and bread. However, the choice for a particular yeast strain or species for a specific industrial application is often based on historical, rather than scientific grounds. Moreover, new biotechnological yeast applications, such as the production of second-generation biofuels, confront yeast with environments and challenges that differ from those encountered in traditional food fermentations. Together, this implies that there are interesting opportunities to isolate or generate yeast variants that perform better than the currently used strains. Here, we discuss the different strategies of strain selection and improvement available for both conventional and nonconventional yeasts. Exploiting the existing natural diversity and using techniques such as mutagenesis, protoplast fusion, breeding, genome shuffling and directed evolution to generate artificial diversity, or the use of genetic modification strategies to alter traits in a more targeted way, have led to the selection of superior industrial yeasts. Furthermore, recent technological advances allowed the development of high-throughput techniques, such as 'global transcription machinery engineering' (gTME), to induce genetic variation, providing a new source of yeast genetic diversity. © 2014 The Authors. FEMS Microbiology Reviews published by John Wiley & Sons Ltd on behalf of Federation of European Microbiological Societies.

Diamond Thin-Film Thermionic Generator

NASA Astrophysics Data System (ADS)

Clewell, J. M.; Ordonez, C. A.; Perez, J. M.

1997-03-01

Since the eighteen-hundreds scientists have sought to develop the highest thermal efficiency in heat engines such as thermionic generators. Modern research in the emerging diamond film industry has indicated the work functions of diamond thin-films can be much less than one electron volt, compelling fresh investigation into their capacity as thermionic generators and inviting new methodology for determining that efficiency. Our objective is to predict the efficiency of a low-work-function, degenerate semiconductor (diamond film) thermionic generator operated as a heat engine between two constant-temperature thermal reservoirs. Our presentation will focus on a theoretical model which predicts the efficiency of the system by employing a Monte Carlo computational technique from which we report results for the thermal efficiency and the thermionic current densities of diamond thin-films.

S&T converging trends in dealing with disaster: A review on AI tools

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hasan, Abu Bakar, E-mail: abakarh@usim.edu.my; Isa, Mohd Hafez Mohd.

Science and Technology (S&T) has been able to help mankind to solve or minimize problems when arise. Different methodologies, techniques and tools were developed or used for specific cases by researchers, engineers, scientists throughout the world, and numerous papers and articles have been written by them. Nine selected cases such as flash flood, earthquakes, workplace accident, fault in aircraft industry, seismic vulnerability, disaster mitigation and management, and early fault detection in nuclear industry have been studied. This paper looked at those cases, and their results showed nearly 60% uses artificial intelligence (AI) as a tool. This paper also did somemore » review that will help young researchers in deciding the types of AI tools to be selected; thus proving the future trends in S&T.« less

The communications industry's requirements and interests. [thunderstorm and lightning data useful to telephone operating companies

NASA Technical Reports Server (NTRS)

Wanaselja, O.

1979-01-01

Of interest to the communications industry are the amplitude, waveshape, duration and frequency of lightning-originated voltage surges and transients on the communications network, including the distribution system and AC power supply circuits. The cloud-to-ground lightning discharge and its characteristics are thought to be most meaningful. Of specific interest are peak current, waveshape, number of flashes, strokes per flash, and zone of influence. Accurate and meaningful lightning data at the local level (telephone district office) is necessary for a decision on the appropriate protection level. In addition to lightning, the protection engineer must consider other factors such as: AC induction, switching surges, ground potential rise, soil resistivity, bonding and grounding techniques, shielding and isolation, and exposure of the telephone loop.

S&T converging trends in dealing with disaster: A review on AI tools

NASA Astrophysics Data System (ADS)

Hasan, Abu Bakar; Isa, Mohd. Hafez Mohd.

2016-01-01

Science and Technology (S&T) has been able to help mankind to solve or minimize problems when arise. Different methodologies, techniques and tools were developed or used for specific cases by researchers, engineers, scientists throughout the world, and numerous papers and articles have been written by them. Nine selected cases such as flash flood, earthquakes, workplace accident, fault in aircraft industry, seismic vulnerability, disaster mitigation and management, and early fault detection in nuclear industry have been studied. This paper looked at those cases, and their results showed nearly 60% uses artificial intelligence (AI) as a tool. This paper also did some review that will help young researchers in deciding the types of AI tools to be selected; thus proving the future trends in S&T.

Synthesis of Engineered Zeolitic Materials: From Classical Zeolites to Hierarchical Core-Shell Materials.

PubMed

Masoumifard, Nima; Guillet-Nicolas, Rémy; Kleitz, Freddy

2018-04-01

The term "engineered zeolitic materials" refers to a class of materials with a rationally designed pore system and active-sites distribution. They are primarily made of crystalline microporous zeolites as the main building blocks, which can be accompanied by other secondary components to form composite materials. These materials are of potential importance in many industrial fields like catalysis or selective adsorption. Herein, critical aspects related to the synthesis and modification of such materials are discussed. The first section provides a short introduction on classical zeolite structures and properties, and their conventional synthesis methods. Then, the motivating rationale behind the growing demand for structural alteration of these zeolitic materials is discussed, with an emphasis on the ongoing struggles regarding mass-transfer issues. The state-of-the-art techniques that are currently available for overcoming these hurdles are reviewed. Following this, the focus is set on core-shell composites as one of the promising pathways toward the creation of a new generation of highly versatile and efficient engineered zeolitic substances. The synthesis approaches developed thus far to make zeolitic core-shell materials and their analogues, yolk-shell, and hollow materials, are also examined and summarized. Finally, the last section concisely reviews the performance of novel core-shell, yolk-shell, and hollow zeolitic materials for some important industrial applications. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Natural Hazards characterisation in industrial practice

NASA Astrophysics Data System (ADS)

Bernardara, Pietro

2017-04-01

The definition of rare hydroclimatic extremes (up to 10-4 annual probability of occurrence) is of the utmost importance for the design of high value industrial infrastructures, such as grids, power plants, offshore platforms. The underestimation as well as the overestimation of the risk may lead to huge costs (ex. mid-life expensive works or overdesign) which may even prevent the project to happen. Nevertheless, the uncertainty associated to the extrapolation towards the rare frequencies are huge and manifold. They are mainly due to the scarcity of observations, the lack of quality on the extreme value records and on the arbitrary choice of the models used for extrapolations. This often put the design engineers in uncomfortable situations when they must choose the design values to use. Providentially, the recent progresses in the earth observation techniques, information technology, historical data collection and weather and ocean modelling are making huge datasets available. A careful use of big datasets of observations and modelled data are leading towards a better understanding of the physics of the underlying phenomena, the complex interactions between them and thus of the extreme events frequency extrapolations. This will move the engineering practice from the single site, small sample, application of statistical analysis to a more spatially coherent, physically driven extrapolation of extreme values. Few examples, from the EDF industrial practice are given to illustrate these progresses and their potential impact on the design approaches.

NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 46: Technical communications in aerospace: A comparison across four countries

NASA Technical Reports Server (NTRS)

Kennedy, John M.; Pinelli, Thomas E.; Hecht, Laura Frye; Barclay, Rebecca O.

1995-01-01

In this paper we describe the preliminary analysis of four groups of aerospace engineering and science students -- student members of the American Institute of Aeronautics and Astronautics (AIAA) and students from universities in Japan, Russia, and Great Britain. We compare: (1) the demographic characteristics of the students; (2) factors that affected their career decision; (3) their career goals and aspirations; (4) their training in technical communication; and (5) their training in techniques for finding and using aerospace scientific and technical information (STI). Many employers in the US aerospace industry think there is a need for increased training of engineering students in technical communication. Engineers in the US and other countries believe that technical communication skills are critical for engineers' professional success. All students in our study agree about the importance of technical communication training for professional success, yet relatively few are happy with the instruction they receive. Overall, we conclude that additional instruction in technical communication and accessing STI would make it easier for students to achieve their career goals.

Analyzing system safety in lithium-ion grid energy storage

NASA Astrophysics Data System (ADS)

Rosewater, David; Williams, Adam

2015-12-01

As grid energy storage systems become more complex, it grows more difficult to design them for safe operation. This paper first reviews the properties of lithium-ion batteries that can produce hazards in grid scale systems. Then the conventional safety engineering technique Probabilistic Risk Assessment (PRA) is reviewed to identify its limitations in complex systems. To address this gap, new research is presented on the application of Systems-Theoretic Process Analysis (STPA) to a lithium-ion battery based grid energy storage system. STPA is anticipated to fill the gaps recognized in PRA for designing complex systems and hence be more effective or less costly to use during safety engineering. It was observed that STPA is able to capture causal scenarios for accidents not identified using PRA. Additionally, STPA enabled a more rational assessment of uncertainty (all that is not known) thereby promoting a healthy skepticism of design assumptions. We conclude that STPA may indeed be more cost effective than PRA for safety engineering in lithium-ion battery systems. However, further research is needed to determine if this approach actually reduces safety engineering costs in development, or improves industry safety standards.

Trial of Engineer Educating of Manufacturing Field in Kagoshima National College of Technology

NASA Astrophysics Data System (ADS)

Nakamura, Itaru; Hombu, Mitsuyuki; Kusuhara, Yoshito; Kashine, Kenji; Sakasegawa, Eiichi; Tashima, Daisuke; Fukidome, Hiromi

In Kagoshima National College of Technology, based on investigation with “the job boost measure investigation work in a power supply area” undertaken in the 2005 fiscal year, we accepted the trust from Kyushu Bureau of Economy, Trade and Industry, and undertook “the small-and-medium-sized-enterprises personnel educating work which utilized the technical college etc.” for three years from the 2006 fiscal year to the 2008 fiscal year. As the trial of engineer educating according to the electrical engineering concept to the manufacturing field based on a conventional result, we act as a professor of the base technique for applying alternative energy (a fuel cell and a solar cell) in which social needs are powerful these days, and aim at aiming at cultivation of the problem-solving type engineer who can contribute to a low carbon society through manufacturing, we undertook this work according to the manufacturing bearer educating work (personnel educating and secured work of the manufacturing field) in the 2009 fiscal year of National Federation of Small Business Associations.

Iowa State University's undergraduate minor, online graduate certificate and resource center in NDE

NASA Astrophysics Data System (ADS)

Bowler, Nicola; Larson, Brian F.; Gray, Joseph N.

2014-02-01

Nondestructive evaluation is a `niche' subject that is not yet offered as an undergraduate or graduate major in the United States. The undergraduate minor in NDE offered within the College of Engineering at Iowa State University (ISU) provides a unique opportunity for undergraduate aspiring engineers to obtain a qualification in the multi-disciplinary subject of NDE. The minor requires 16 credits of course work within which a core course and laboratory in NDE are compulsory. The industrial sponsors of Iowa State's Center for Nondestructive Evaluation, and others, strongly support the NDE minor and actively recruit students from this pool. Since 2007 the program has graduated 10 students per year and enrollment is rising. In 2011, ISU's College of Engineering established an online graduate certificate in NDE, accessible not only to campus-based students but also to practicing engineers via the web. The certificate teaches the fundamentals of three major NDE techniques; eddy-current, ultrasonic and X-ray methods. This paper describes the structure of these programs and plans for development of an online, coursework-only, Master of Engineering in NDE and thesis-based Master of Science degrees in NDE.

Advances in protease engineering for laundry detergents.

PubMed

Vojcic, Ljubica; Pitzler, Christian; Körfer, Georgette; Jakob, Felix; Ronny Martinez; Maurer, Karl-Heinz; Schwaneberg, Ulrich

2015-12-25

Proteases are essential ingredients in modern laundry detergents. Over the past 30 years, subtilisin proteases employed in the laundry detergent industry have been engineered by directed evolution and rational design to tailor their properties towards industrial demands. This comprehensive review discusses recent success stories in subtilisin protease engineering. Advances in protease engineering for laundry detergents comprise simultaneous improvement of thermal resistance and activity at low temperatures, a rational strategy to modulate pH profiles, and a general hypothesis for how to increase promiscuous activity towards the production of peroxycarboxylic acids as mild bleaching agents. The three protease engineering campaigns presented provide in-depth analysis of protease properties and have identified principles that can be applied to improve or generate enzyme variants for industrial applications beyond laundry detergents. Copyright © 2015 Elsevier B.V. All rights reserved.

A Buddhist perspective on industrial engineering and the design of work.

PubMed

Lee, Wei-Tau; Blumenthal, James A; Funk, Kenneth H

2014-06-01

The modern way of life is highly dependent upon the production of goods by industrial organizations that are in turn dependent upon their workers for their ongoing operations. Even though more than a century has passed since the dawn of the industrial revolution, many dangerous aspects of work, both physical and mental, remain in the workplace today. Using Buddhist philosophical principles, this paper suggests that although many sources of the problem reside within the larger society, the industrial engineer is still a key factor in bettering work and providing a workplace suitable for their fellow workers. Drawing on these insights, we present a number of work design guidelines that industrial engineers who abide by Buddhist principles could practice to help overcome some of the many sufferings produced by modern work.

Human factors in industrial systems: 40 years on.

PubMed

Drury, Colin G

2008-06-01

I evaluate the contribution of a pioneering Human Factors special issue on human factors in industrial systems. Papers on the content of the journal's first 10 years showed that industrial human factors/ergonomics (HF/E) in 1969 was quite a rarity in the journal and the society. The 12 papers in the special issue are reviewed briefly and show a wide range of topics, including traditional industrial engineering, physical HF/E, and more mainstream applications of HF/E in this domain similar to those in military and aerospace domains. The evaluation is through citations, later journal content, society technical group membership, and specific influences of Harris's own paper in the issue. The expected direct citation influence of this special issue was not found: Citation counts were in line with all papers in Human Factors. However, other journals have been founded in North America that serve industrial HF/E and provide an outlet for more papers per year than Human Factors. In addition, the industrial domain is well represented in the Human Factors and Ergonomics Society. Finally, Harris's paper has been influential in the specific area of HF/E in inspection. Industrial HF/E is now more accepted within the HF/E community, although largely in the physical ergonomics subspecialty. There is now evidence of use of HF/E techniques more broadly in industry, including service as well manufacturing enterprises.

Microbial Enzyme Production Using Lignocellulosic Food Industry Wastes as Feedstock: A Review

PubMed Central

Ravindran, Rajeev; Jaiswal, Amit K.

2016-01-01

Enzymes are of great importance in the industry due to their substrate and product specificity, moderate reaction conditions, minimal by-product formation and high yield. They are important ingredients in several products and production processes. Up to 30% of the total production cost of enzymes is attributed to the raw materials costs. The food industry expels copious amounts of processing waste annually, which is mostly lignocellulosic in nature. Upon proper treatment, lignocellulose can replace conventional carbon sources in media preparations for industrial microbial processes, such as enzyme production. However, wild strains of microorganisms that produce industrially important enzymes show low yield and cannot thrive on artificial substrates. The application of recombinant DNA technology and metabolic engineering has enabled researchers to develop superior strains that can not only withstand harsh environmental conditions within a bioreactor but also ensure timely delivery of optimal results. This article gives an overview of the current complications encountered in enzyme production and how accumulating food processing waste can emerge as an environment-friendly and economically feasible solution for a choice of raw material. It also substantiates the latest techniques that have emerged in enzyme purification and recovery over the past four years. PMID:28952592

Engineering Philosophy: Theories of Technology, German Idealism, and Social Order in High-Industrial Germany.

PubMed

Voskuhl, Adelheid

During the so-called "Second Industrial Revolution," engineers were constituting themselves as a new social and professional group, and found themselves in often fierce competition with existing elites-the military, the nobility, and educated bourgeois mandarins-whose roots went back to medieval and early modern pre-industrial social orders. During that same time, engineers also discovered the discipline of philosophy: as a means to express their intellectual and social agendas, and to theorize technology and its relationship to art, history, culture, philosophy, and the state. This article analyzes engineers' own philosophical writings about technology as well as the institutions in which they composed them in 1910s and 1920s Germany. It emphasizes engineers' contributions to well-known discourses founded by canonical philosophers, the role of preindustrial economies and their imagination in such philosophies, and the role of both the history and the philosophy of technology in engineers' desire for upward social mobility.

Implementation of partnership management model of SMK (Vocational High School) with existing industries in mechanical engineering expertise in Central Java

NASA Astrophysics Data System (ADS)

Sumbodo, Wirawan; Pardjono, Samsudi, Rahadjo, Winarno Dwi

2018-03-01

This study aims to determine the existing conditions of implementation of partnership management model of SMK with the industry on the mechanical engineering expertise in Central Java. The method used is descriptive analysis. The research result shows that the implementation of partnership management model of SMK based on new existing industry produces ready graduates of 62.5% which belongs to low category, although the partnership program of SMK with the industry is done well with the average score of 3.17. As many as 37.5% of SMK graduates of Mechanical Engineering Expertise Program choose to continue their studies or to be an entrepreneur. It is expected that the partnership model of SMK with the industry can be developed into a reference for government policy in developing SMK that is able to produce graduates who are ready to work according to the needs of partner industry.

[Fermentation production of microbial catalase and its application in textile industry].

PubMed

Zhang, Dongxu; Du, Guocheng; Chen, Jian

2010-11-01

Microbial catalase is an important industrial enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. This enzyme has great potential of application in food, textile and pharmaceutical industries. The production of microbial catalase has been significantly improved thanks to advances in bioprocess engineering and genetic engineering. In this paper, we review the progresses in fermentation production of microbial catalase and its application in textile industry. Among these progresses, we will highlight strain isolation, substrate and environment optimization, enzyme induction, construction of engineering strains and application process optimization. Meanwhile, we also address future research trends for microbial catalase production and its application in textile industry. Molecular modification (site-directed mutagenesis and directed revolution) will endue catalase with high pH and temperature stabilities. Improvement of catalase production, based on the understanding of induction mechanism and the process control of recombinant stain fermentation, will further accelerate the application of catalase in textile industry.

Research on Building Education & Workforce Capacity in Systems Engineering

DTIC Science & Technology

2012-09-30

Science Coast Guard Academy Chris Lund, Research Engineer USCG R&D center Civil Engineering Coast Guard Academy Scot T. Tripp, Program Manager USCG...74 researchers Coast Guard Academy Scot T. Tripp, Program Manager Internal institutional USCG R&D center... Woods Industry Lockheed Martin Aeronautics Company Defense contracted system development and analysis Stevens Tom Newby Industry Buro

Assessing the Higher National Diploma Chemical Engineering Programme in Ghana: Students' Perspective

ERIC Educational Resources Information Center

Boateng, Cyril D.; Bensah, Edem Cudjoe; Ahiekpor, Julius C.

2012-01-01

Chemical engineers have played key roles in the growth of the chemical and allied industries in Ghana but indigenous industries that have traditionally been the domain of the informal sector need to be migrated to the formal sector through the entrepreneurship and innovation of chemical engineers. The Higher National Diploma Chemical Engineering…

Polytechnic Engineering Mathematics: Assessing Its Relevance to the Productivity of Industries in Uganda

ERIC Educational Resources Information Center

Jehopio, Peter J.; Wesonga, Ronald

2017-01-01

Background: The main objective of the study was to examine the relevance of engineering mathematics to the emerging industries. The level of abstraction, the standard of rigor, and the depth of theoretical treatment are necessary skills expected of a graduate engineering technician to be derived from mathematical knowledge. The question of whether…

Is Chinese Software Engineering Professionalizing or Not?: Specialization of Knowledge, Subjective Identification and Professionalization

ERIC Educational Resources Information Center

Yang, Yan

2012-01-01

Purpose: This paper aims to discuss the challenge for the classical idea of professionalism in understanding the Chinese software engineering industry after giving a close insight into the development of this industry as well as individual engineers with a psycho-societal perspective. Design/methodology/approach: The study starts with the general…

Support for Different Roles in Software Engineering Master's Thesis Projects

ERIC Educational Resources Information Center

Host, M.; Feldt, R.; Luders, F.

2010-01-01

Like many engineering programs in Europe, the final part of most Swedish software engineering programs is a longer project in which the students write a Master's thesis. These projects are often conducted in cooperation between a university and industry, and the students often have two supervisors, one at the university and one in industry. In…

Engineering in Scotland's Colleges: A Report by HM Inspectors for the Scottish Funding Council

ERIC Educational Resources Information Center

Her Majesty's Inspectorate of Education, 2007

2007-01-01

Engineering has played an important role in Scotland's industrial history. Over the years, the skills requirements of industry have changed as the technology has progressed and the industrial base of the country has developed. Over the past decade, there have been substantial changes in the employment opportunities for people with engineering…

A Spiral Step-by-Step Educational Method for Cultivating Competent Embedded System Engineers to Meet Industry Demands

ERIC Educational Resources Information Center

Jing,Lei; Cheng, Zixue; Wang, Junbo; Zhou, Yinghui

2011-01-01

Embedded system technologies are undergoing dramatic change. Competent embedded system engineers are becoming a scarce resource in the industry. Given this, universities should revise their specialist education to meet industry demands. In this paper, a spirally tight-coupled step-by-step educational method, based on an analysis of industry…

Developing Design and Management Skills for Senior Industrial Engineering Students

ERIC Educational Resources Information Center

Urbanic, R. J.

2011-01-01

In Canadian engineering institutions, a significant design experience must occur in the final year of study. In the Department of Industrial and Manufacturing Systems at the University of Windsor, unsolved, open ended projects sponsored by industrial partners from a variety of sectors are provided to the student teams in order for them to apply…

Library Service to Industry at USC: The Industrial Associates of the School of Engineering.

ERIC Educational Resources Information Center

Frohmberg, Katherine A.

Special libraries in Southern California and the San Francisco Bay Area who were members of the University of Southern California (USC) School of Engineering Industrial Associate program were surveyed on their use of the USC program and other similar programs. The questionnaire was designed to discover the attitudes and needs of the Industrial…

Technician Career Opportunities in Engineering Technology.

ERIC Educational Resources Information Center

Engineers' Council for Professional Development, New York, NY.

Career opportunities for engineering technicians are available in the technologies relating to air conditioning, heating, and refrigeration, aviation and aerospace, building construction, chemical engineering, civil engineering, electrical engineering, electronics, industrial engineering, instrumentation, internal combustion engines, mechanical…

Engineering Technology Education: Bibliography, 1988.

ERIC Educational Resources Information Center

Dyrud, Marilyn A.

1989-01-01

Lists articles and books related to engineering technology education published in 1988. Items are grouped administration, aeronautical, architectural, CAD/CAM, civil, computers, curriculum, electrical/electronics, industrial, industry/government/employers, instructional technology, laboratories, lasers, liberal studies, manufacturing, mechanical,…

46 CFR 11.530 - Endorsements for engineers of uninspected fishing industry vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... applies to endorsements for chief and assistant engineers of all vessels, however propelled, navigating the high seas, which are documented to engage in the fishing industry, with the exception of: (1...

A research feasibility study proposal for conducting experimental research in curriculum sharing via Communications Technology Satellite among institutions having large minority enrollments

NASA Technical Reports Server (NTRS)

Williams, L., Jr.

1978-01-01

The applicability of the tele-conference method of curriculum sharing as well as the sharing of scientific research results between universities and industrial organizations was evaluated in relation to other techniques and methods. Ten universities cooperated with NC A&T State University in an effort to increase the number of minority scientists and engineers in the USA via the utilization of the communication features of satellites. Research activities, experiments and studies in curriculum sharing are described as well as the techniques, interconnections and equipment utilized. Suggested methods and recommendations for a continuation of innovative applications of satellite technology in higher education at NC A&T State University are included.

["Two professions for a single task". The introduction of chemical engineering in Spain during the first Francoism].

PubMed

Toca, Angel

2006-01-01

Through the first half of the 20th century, chemical engineering was established as an academic option in the training of specialists for the North-American and European chemical industry, whereas it was not a special field of study in Spain until the 1990s. The reason for this delay was a battle of interests between chemist and industrial engineers to control this career during the first Francoism. This article will try to show the development and professionalization of specialists for the Spanish chemical industry.

Engineering Thermostable Microbial Xylanases Toward its Industrial Applications.

PubMed

Kumar, Vishal; Dangi, Arun Kumar; Shukla, Pratyoosh

2018-03-01

Xylanases are one of the important hydrolytic enzymes which hydrolyze the β-1, 4 xylosidic linkage of the backbone of the xylan polymeric chain which consists of xylose subunits. Xylanases are mainly found in plant cell walls and are produced by several kinds of microorganisms such as fungi, bacteria, yeast, and some protozoans. The fungi are considered as most potent xylanase producers than that of yeast and bacteria. There is a broad series of industrial applications for the thermostable xylanase as an industrial enzyme. Thermostable xylanases have been used in a number of industries such as paper and pulp industry, biofuel industry, food and feed industry, textile industry, etc. The present review explores xylanase-substrate interactions using gene-editing tools toward the comprehension in improvement in industrial stability of xylanases. The various protein-engineering and metabolic-engineering methods have also been explored to improve operational stability of xylanase. Thermostable xylanases have also been used for improvement in animal feed nutritional value. Furthermore, they have been used directly in bakery and breweries, including a major use in paper and pulp industry as a biobleaching agent. This present review envisages some of such applications of thermostable xylanases for their bioengineering.

Technological Microbiology: Development and Applications

PubMed Central

Vitorino, Luciana C.; Bessa, Layara A.

2017-01-01

Over thousands of years, modernization could be predicted for the use of microorganisms in the production of foods and beverages. However, the current accelerated pace of new food production is due to the rapid incorporation of biotechnological techniques that allow the rapid identification of new molecules and microorganisms or even the genetic improvement of known species. At no other time in history have microorganisms been so present in areas such as agriculture and medicine, except as recognized villains. Currently, however, beneficial microorganisms such as plant growth promoters and phytopathogen controllers are required by various agricultural crops, and many species are being used as biofactories of important pharmacological molecules. The use of biofactories does not end there: microorganisms have been explored for the synthesis of diverse chemicals, fuel molecules, and industrial polymers, and strains environmentally important due to their biodecomposing or biosorption capacity have gained interest in research laboratories and in industrial activities. We call this new microbiology Technological Microbiology, and we believe that complex techniques, such as heterologous expression and metabolic engineering, can be increasingly incorporated into this applied science, allowing the generation of new and improved products and services. PMID:28539920

Modelling and analysis of the wetting characteristics of ink for display applications with the surface evolution technique

NASA Astrophysics Data System (ADS)

Shin, Dong-Youn; Brakke, Kenneth A.

2009-06-01

Piezo drop-on-demand inkjet printing technology has attracted the attention of display industries for the production of colour filters for thin film transistor liquid crystal displays (TFT LCD) because of the opportunity of reducing manufacturing cost. Colourant ink droplets ejected from inkjet nozzles selectively fill subpixels surrounded with black matrix (BM). Surface energy differences between the glass substrate and the BM generally guide this ink filling process. This colourant ink filling process, however, results from the complex hydrodynamic interaction of ink with the substrate and the BM. Neither computationally expensive numerical methods nor time and cost expensive experiments are suitable for the derivation of optimum surface conditions at the early development stage. In this study, a more concise surface evolution technique is proposed and ways to find the optimum surface conditions for the fabrication of TFT LCD colour filters and polymer light emitting devices are discussed, which might be useful for chemists and developers of ink and BM material, as well as for process engineers in display industries.

Nondeterministic Approaches and Their Potential for Future Aerospace Systems

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler)

2001-01-01

This document contains the proceedings of the Training Workshop on Nondeterministic Approaches and Their Potential for Future Aerospace Systems held at NASA Langley Research Center, Hampton, Virginia, May 30-3 1, 2001. The workshop was jointly sponsored by Old Dominion University's Center for Advanced Engineering Environments and NASA. Workshop attendees were from NASA, other government agencies, industry, and universities. The objectives of the workshop were to give overviews of the diverse activities in nondeterministic approaches, uncertainty management methodologies, reliability assessment and risk management techniques, and to identify their potential for future aerospace systems.

Operational experience in underwater photogrammetry

NASA Astrophysics Data System (ADS)

Leatherdale, John D.; John Turner, D.

Underwater photogrammetry has become established as a cost-effective technique for inspection and maintenance of platforms and pipelines for the offshore oil industry. A commercial service based in Scotland operates in the North Sea, USA, Brazil, West Africa and Australia. 70 mm cameras and flash units are built for the purpose and analytical plotters and computer graphics systems are used for photogrammetric measurement and analysis of damage, corrosion, weld failures and redesign of underwater structures. Users are seeking simple, low-cost systems for photogrammetric analysis which their engineers can use themselves.

Preliminary Component Integration Utilizing Rapid Prototyping Techniques

NASA Technical Reports Server (NTRS)

Cooper, K.; Salvail, P.

2001-01-01

One of the most costly errors committed during the development of an element to be used in the space industry is the lack of communication between design and manufacturing engineers. A very important tool that should be utilized in the development stages by both design and manufacturing disciplines is rapid prototyping. Communication levels are intensified with the injection of functional models that are generated from a drawing. At the Marshall Space Flight Center, this discipline is utilized on a more frequent basis as a manner by which hardware may be tested for design and material compatibility.

The National Shipbuilding Research Program. Application of Industrial Engineering Techniques to Reduce Workers’ Compensation and Environmental Costs

DTIC Science & Technology

1999-10-01

TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Surface Warfare Center CD Code 2230-Design Integration...Tools Bldg 192, Room 128 9500 MacArthur Blvd Bethesda, MD 20817-5700 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S...Implementation of Task 2.4 • Task 7.0 Conduct Workshops • Task 8.0 Final Report To ensure success with the project, the research needed to be performed at the

Thermal History Of PMRs Via Pyrolysis-Gas Chromatography

NASA Technical Reports Server (NTRS)

Gluyas, Richard E.; Alston, William B.; Snyder, William J.

1994-01-01

Pyrolysis-gas chromatography (PY-GC) useful as analytical technique to determine extents of cure or postcure of PMR-15 polyimides and to lesser extent, cumulative thermal histories of PMR-15 polyimides exposed to high temperatures. Also applicable for same purposes to other PMR polyimides and to composite materials containing PMR polyimides. Valuable in reducing costs and promoting safety in aircraft industry by helping to identify improperly cured or postcured PMR-15 composite engine and airframe components and helping to identify composite parts nearing ends of their useful lives.

Characterization of manufactured TiO2 nanoparticles

NASA Astrophysics Data System (ADS)

Motzkus, C.; Macé, T.; Vaslin-Reimann, S.; Ausset, P.; Maillé, M.

2013-04-01

Technological advances in nanomaterials have allowed the development of new applications in industry, increasing the probability of finding airborne manufactured and engineered nano-objects in the workplace, as well as in ambient air. Scientific studies on health and environmental risks have indicated that airborne nano-objects in ambient air have potential adverse effects on the health of exposed workers and the general population. For regulatory purposes, ambient measurements of particulate matter are based on the determination of mass concentrations for PM10 and PM2.5, as regulated in the European Directive 2008/50/EC. However, this legislation is not suitable for airborne manufactured and engineered nano-objects. Parameters characterising ultrafine particles, such as particle number concentration and size distribution, are under consideration for future health-based legislation, to monitor workplaces and to control industrial processes. Currently, there are no existing regulations covering manufactured airborne nano-objects. There is therefore a clear, unaddressed need to focus on the toxicology and exposure assessment of nano-objects such as titanium dioxide (TiO2), which are manufactured and engineered in large quantities in industry. To perform reliable toxicology studies it is necessary to determine the relevant characteristics of nano-objects, such as morphology, surface area, agglomeration, chemical composition, particle size and concentration, by applying traceable methods. Manufacturing of nanomaterials, and their use in industrial applications, also require traceable characterisation of the nanomaterials, particularly for quality control of the process. The present study arises from the OECD WPMN sponsorship programme, supported by the French Agency for Environmental and Occupational Health Safety (ANSES), in order to develop analytical methods for the characterization of TiO2 nanoparticles in size and count size distribution, based on different techniques to characterize five different manufactured TiO2 nanoparticles. In this study, different measurement techniques have been implemented: Transmission Electron Microscopy (TEM), Scanning Mobility Particle Sizer (SMPS) and Aerodynamic Particle Sizer (APS). The TEM results lead to a relatively good agreement between data from the manufacturer and our characterizations of primary particle size. With regard to the dustiness, the results show a strong presence of agglomerates / aggregates of primary particles and a significant presence of emitted airborne nanoparticles with a diameter below 100 nm (composed of isolated primary particles and small aggregates / agglomerates formed from a few primary particles): the number proportion of these particles varies from 0 to 44 % in the measurement range 14-360 nm depending on the types of powders and corrections of measurements.

Engineering Technology Education Bibliography, 1990.

ERIC Educational Resources Information Center

Dyrud, Marilyn A.

1991-01-01

Lists over 340 materials published in 1990 related to engineering technology education and grouped under the following headings: administration; architectural; computer-assisted design/management (CAD/CAM); civil; computers; curriculum; electrical/electronics; industrial; industry/government/employers; instructional technology; laboratories;…

Electric Utility Transmission and Distribution Line Engineering Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peter McKenny

2010-08-31

Economic development in the United States depends on a reliable and affordable power supply. The nation will need well educated engineers to design a modern, safe, secure, and reliable power grid for our future needs. An anticipated shortage of qualified engineers has caused considerable concern in many professional circles, and various steps are being taken nationwide to alleviate the potential shortage and ensure the North American power system's reliability, and our world-wide economic competitiveness. To help provide a well-educated and trained workforce which can sustain and modernize the nation's power grid, Gonzaga University's School of Engineering and Applied Science hasmore » established a five-course (15-credit hour) Certificate Program in Transmission and Distribution (T&D) Engineering. The program has been specifically designed to provide working utility engineering professionals with on-line access to advanced engineering courses which cover modern design practice with an industry-focused theoretical foundation. A total of twelve courses have been developed to-date and students may select any five in their area of interest for the T&D Certificate. As each course is developed and taught by a team of experienced engineers (from public and private utilities, consultants, and industry suppliers), students are provided a unique opportunity to interact directly with different industry experts over the eight weeks of each course. Course material incorporates advanced aspects of civil, electrical, and mechanical engineering disciplines that apply to power system design and are appropriate for graduate engineers. As such, target students for the certificate program include: (1) recent graduates with a Bachelor of Science Degree in an engineering field (civil, mechanical, electrical, etc.); (2) senior engineers moving from other fields to the utility industry (i.e. paper industry to utility engineering or project management positions); and (3) regular working professionals wishing to update their skills or increase their knowledge of utility engineering design practices and procedures. By providing graduate educational opportunities for the above groups, the T&D Program will help serve a strong industry need for training the next generation of engineers in the cost-effective design, construction, operation, and maintenance of modern electrical transmission and distribution systems. In addition to developing the on-line engineering courses described above, the T&D Program also focused significant efforts towards enhancing the training opportunities available to power system operators in the northwest. These efforts have included working with outside vendors to provide NERC-approved training courses in Gonzaga University's (GU) system operator training facility, support for an accurate system model which can be used in regional blackstart exercises, and the identification of a retired system operator who could provide actual regional training courses. The GU system operator training facility is also being used to recruit young workers, veterans, and various under-represented groups to the utility industry. Over the past three years students from Columbia Gorge Community College, Spokane Falls Community College, Walla Walla Community College, Central Washington University, Eastern Washington University, Gonzaga University, and various local high schools have attended short (one-day) system operator training courses free of charge. These collaboration efforts has been extremely well received by both students and industry, and meet T&D Program objectives of strengthening the power industry workforce while bridging the knowledge base across power worker categories, and recruiting new workers to replace a predominantly retirement age workforce. In the past three years the T&D Program has provided over 170 utility engineers with access to advanced engineering courses, been involved in training more than 300 power system operators, and provided well over 500 college and high school students with an experience in running a power system simulator and an exposure to various utility-related professions and craft trades.« less

Systems Biology of Industrial Microorganisms

NASA Astrophysics Data System (ADS)

Papini, Marta; Salazar, Margarita; Nielsen, Jens

The field of industrial biotechnology is expanding rapidly as the chemical industry is looking towards more sustainable production of chemicals that can be used as fuels or building blocks for production of solvents and materials. In connection with the development of sustainable bioprocesses, it is a major challenge to design and develop efficient cell factories that can ensure cost efficient conversion of the raw material into the chemical of interest. This is achieved through metabolic engineering, where the metabolism of the cell factory is engineered such that there is an efficient conversion of sugars, the typical raw materials in the fermentation industry, into the desired product. However, engineering of cellular metabolism is often challenging due to the complex regulation that has evolved in connection with adaptation of the different microorganisms to their ecological niches. In order to map these regulatory structures and further de-regulate them, as well as identify ingenious metabolic engineering strategies that full-fill mass balance constraints, tools from systems biology can be applied. This involves both high-throughput analysis tools like transcriptome, proteome and metabolome analysis, as well as the use of mathematical modeling to simulate the phenotypes resulting from the different metabolic engineering strategies. It is in fact expected that systems biology may substantially improve the process of cell factory development, and we therefore propose the term Industrial Systems Biology for how systems biology will enhance the development of industrial biotechnology for sustainable chemical production.

Systems biology of industrial microorganisms.

PubMed

Papini, Marta; Salazar, Margarita; Nielsen, Jens

2010-01-01

The field of industrial biotechnology is expanding rapidly as the chemical industry is looking towards more sustainable production of chemicals that can be used as fuels or building blocks for production of solvents and materials. In connection with the development of sustainable bioprocesses, it is a major challenge to design and develop efficient cell factories that can ensure cost efficient conversion of the raw material into the chemical of interest. This is achieved through metabolic engineering, where the metabolism of the cell factory is engineered such that there is an efficient conversion of sugars, the typical raw materials in the fermentation industry, into the desired product. However, engineering of cellular metabolism is often challenging due to the complex regulation that has evolved in connection with adaptation of the different microorganisms to their ecological niches. In order to map these regulatory structures and further de-regulate them, as well as identify ingenious metabolic engineering strategies that full-fill mass balance constraints, tools from systems biology can be applied. This involves both high-throughput analysis tools like transcriptome, proteome and metabolome analysis, as well as the use of mathematical modeling to simulate the phenotypes resulting from the different metabolic engineering strategies. It is in fact expected that systems biology may substantially improve the process of cell factory development, and we therefore propose the term Industrial Systems Biology for how systems biology will enhance the development of industrial biotechnology for sustainable chemical production.

The application of powerful promoters to enhance gene expression in industrial microorganisms.

PubMed

Zhou, Shenghu; Du, Guocheng; Kang, Zhen; Li, Jianghua; Chen, Jian; Li, Huazhong; Zhou, Jingwen

2017-02-01

Production of useful chemicals by industrial microorganisms has been attracting more and more attention. Microorganisms screened from their natural environment usually suffer from low productivity, low stress resistance, and accumulation of by-products. In order to overcome these disadvantages, rational engineering of microorganisms to achieve specific industrial goals has become routine. Rapid development of metabolic engineering and synthetic biology strategies provide novel methods to improve the performance of industrial microorganisms. Rational regulation of gene expression by specific promoters is essential to engineer industrial microorganisms for high-efficiency production of target chemicals. Identification, modification, and application of suitable promoters could provide powerful switches at the transcriptional level for fine-tuning of a single gene or a group of genes, which are essential for the reconstruction of pathways. In this review, the characteristics of promoters from eukaryotic, prokaryotic, and archaea microorganisms are briefly introduced. Identification of promoters based on both traditional biochemical and systems biology routes are summarized. Besides rational modification, de novo design of promoters to achieve gradient, dynamic, and logic gate regulation are also introduced. Furthermore, flexible application of static and dynamic promoters for the rational engineering of industrial microorganisms is highlighted. From the perspective of powerful promoters in industrial microorganisms, this review will provide an extensive description of how to regulate gene expression in industrial microorganisms to achieve more useful goals.

Pathways and Challenges to Innovation in Aerospace

NASA Technical Reports Server (NTRS)

Terrile, Richard J.

2010-01-01

This paper explores impediments to innovation in aerospace and suggests how successful pathways from other industries can be adopted to facilitate greater innovation. Because of its nature, space exploration would seem to be a ripe field of technical innovation. However, engineering can also be a frustratingly conservative endeavor when the realities of cost and risk are included. Impediments like the "find the fault" engineering culture, the treatment of technical risk as almost always evaluated in terms of negative impact, the difficult to account for expansive Moore's Law growth when making predictions, and the stove-piped structural organization of most large aerospace companies and federally funded research laboratories tend to inhibit cross-cutting technical innovation. One successful example of a multi-use cross cutting application that can scale with Moore's Law is the Evolutionary Computational Methods (ECM) technique developed at the Jet Propulsion Lab for automated spectral retrieval. Future innovations like computational engineering and automated design optimization can potentially redefine space exploration, but will require learning lessons from successful innovators.

Open Source Patient-Controlled Analgesic Pump Requirements Documentation

PubMed Central

Larson, Brian R.; Hatcliff, John; Chalin, Patrice

2014-01-01

The dynamic nature of the medical domain is driving a need for continuous innovation and improvement in techniques for developing and assuring medical devices. Unfortunately, research in academia and communication between academics, industrial engineers, and regulatory authorities is hampered by the lack of realistic non-proprietary development artifacts for medical devices. In this paper, we give an overview of a detailed requirements document for a Patient-Controlled Analgesic (PCA) pump developed under the US NSF’s Food and Drug Administration (FDA) Scholar-in-Residence (SIR) program. This 60+ page document follows the methodology outlined in the US Federal Aviation Administrations (FAA) Requirements Engineering Management Handbook (REMH) and includes a domain overview, use cases, statements of safety & security requirements, and formal top-level system architectural description. Based on previous experience with release of a requirements document for a cardiac pacemaker that spawned a number of research and pedagogical activities, we believe that the described PCA requirements document can be an important research enabler within the formal methods and software engineering communities. PMID:24931440

Establishment of cell surface engineering and its development.

PubMed

Ueda, Mitsuyoshi

2016-07-01

Cell surface display of proteins/peptides has been established based on mechanisms of localizing proteins to the cell surface. In contrast to conventional intracellular and extracellular (secretion) expression systems, this method, generally called an arming technology, is particularly effective when using yeasts as a host, because the control of protein folding that is often required for the preparation of proteins can be natural. This technology can be employed for basic and applied research purposes. In this review, I describe various strategies for the construction of engineered yeasts and provide an outline of the diverse applications of this technology to industrial processes such as the production of biofuels and chemicals, as well as bioremediation and health-related processes. Furthermore, this technology is suitable for novel protein engineering and directed evolution through high-throughput screening, because proteins/peptides displayed on the cell surface can be directly analyzed using intact cells without concentration and purification. Functional proteins/peptides with improved or novel functions can be created using this beneficial, powerful, and promising technique.

Status of FAA Studies in Thermal Acoustics

NASA Astrophysics Data System (ADS)

Lively, John; Ouyang, Zhong; Brasche, Lisa; Holland, Steve; Eisenmann, David; Bantel, Tom; Hassan, Waled

2008-02-01

As with many aerospace applications, commercial jet engine components are operated in demanding environments, often at extreme temperature and stress conditions. The predominant used surface inspection method used on these components is fluorescent penetrant inspection. Research has been ongoing for a number of years on a new technology using a short burst of low frequency (˜20 KHz) ultrasound to "heat up" cracks and make them visible in the infrared range. The basic premise of the Thermal Acoustic method is to use an energy source with recent efforts using an ultrasonic horn originally intended for use in ultrasonic welding to excite the component. The energy source causes an increase in local heating, which is detectable with infrared cameras typically used in Thermographic inspection. While considerable research is underway, additional information on the sensitivity and applicability of this technique to engine components and alloys is needed prior to widespread use in the aviation industry. The purpose of this program is to provide additional data to determine applicability of this method to engine components.

Compliance revisited: pharmaceutical drug trials in the era of the contract research organization.

PubMed

Jonvallen, Petra

2009-12-01

Over the past decade, the management of clinical trials of pharmaceuticals has become a veritable industry, as evidenced by the emergence and proliferation of contract research organizations (CROs) that co-ordinate and monitor trials. This article focuses on work performed by one CRO involved in the introduction of new software, modelled on industrial production processes, into clinical trial practices. It investigates how this new management technique relates to the work performed in the clinic to ensure that trial participants comply with the protocol. Using an analytical distinction between 'classical' management work and invisible work, the article contextualizes the meaning of compliance in the clinic and suggests that the work involved in producing compliance should be taken into consideration by those concerned with validity of trials, as clinical trials are put under private industrial management. The article builds on participant observation at a Swedish university hospital and interviews the nurses, dieticians, doctors and a software engineer, all part of a team involved in pharmaceutical drug trials on a potential obesity drug.

USAF/SCEEE Summer Faculty Research Program (1982). Research Reports. Volume 2.

DTIC Science & Technology

1982-10-01

Engineering (802) 658-3330 Assigned: RADC/Griffiss Dr. Milton J. Alexander Degree: D.B.A., Management , 1968 Professor Specialty: Management ...Information Auburn University Systems, Operational Management Department Research Auburn, AL 36830 Assigned: LMC (205) 826-4730 Dr. Gary L. Allen Degree: Ph.D...Ph.D., Industrial Professor Engineering, 1951 Oklahoma State University Specialty: Project Management , Industrial Engineering & Management Dept

An Alternative Educational Approach for an Inorganic Chemistry Laboratory Course in Industrial and Chemical Engineering

ERIC Educational Resources Information Center

Garces, Andres; Sanchez-Barba, Luis Fernando

2011-01-01

We describe an alternative educational approach for an inorganic chemistry laboratory module named "Experimentation in Chemistry", which is included in Industrial Engineering and Chemical Engineering courses. The main aims of the new approach were to reduce the high levels of failure and dropout on the module and to make the content match the…

Evaluating the Competency Mismatch between Master of Engineering Graduates and Industry Needs in China

ERIC Educational Resources Information Center

Peng, Lijun; Zhang, Shulin; Gu, Jibao

2016-01-01

This study investigates the mismatch between the educational attainment of a graduate with a Master of Engineering (MEng) degree and the industry needs in China. A competency list for MEng graduates from the perspective of industry needs was constructed. And a survey was conducted among MEng graduate students, alumni, and employers to assess the…

Industry careers for the biomedical engineer.

PubMed

Munzner, Robert F

2004-01-01

This year's conference theme is "linkages for innovation in biomedicine." Biomedical engineers, especially those transitioning their career from academic study into medical device industry, will play a critical role in converting the fruits of scientific research into the reality of modern medical devices. This special session is organized to help biomedical engineers to achieve their career goals more effectively. Participants will have opportunities to hear from and interact with leading industrial experts on many issues. These may include but not limited to 1) career paths for biomedical engineers (industrial, academic, or federal; technical vs. managerial track; small start-up or large established companies); 2) unique design challenges and regulatory requirements in medical device development; 3) aspects of a successful biomedical engineering job candidate (such as resume, interview, follow-up). Suggestions for other topics are welcome and should be directed to xkong@ieee.org The distinguished panelists include: Xuan Kong, Ph.D., VP of Research, NEUROMetrix Inc, Waltham, MA Robert F. Munzner, Ph.D., Medical Device Consultant, Doctor Device, Herndon, VA Glen McLaughlin, Ph.D., VP of Engineering and CTO, Zonare Medical System Inc., Mountain View, CA Grace Bartoo, Ph.D., RAC, General Manager, Decus Biomedical LLC San Carlos, CA.

Synthetic biology advances and applications in the biotechnology industry: a perspective.

PubMed

Katz, Leonard; Chen, Yvonne Y; Gonzalez, Ramon; Peterson, Todd C; Zhao, Huimin; Baltz, Richard H

2018-06-18

Synthetic biology is a logical extension of what has been called recombinant DNA (rDNA) technology or genetic engineering since the 1970s. As rDNA technology has been the driver for the development of a thriving biotechnology industry today, starting with the commercialization of biosynthetic human insulin in the early 1980s, synthetic biology has the potential to take the industry to new heights in the coming years. Synthetic biology advances have been driven by dramatic cost reductions in DNA sequencing and DNA synthesis; by the development of sophisticated tools for genome editing, such as CRISPR/Cas9; and by advances in informatics, computational tools, and infrastructure to facilitate and scale analysis and design. Synthetic biology approaches have already been applied to the metabolic engineering of microorganisms for the production of industrially important chemicals and for the engineering of human cells to treat medical disorders. It also shows great promise to accelerate the discovery and development of novel secondary metabolites from microorganisms through traditional, engineered, and combinatorial biosynthesis. We anticipate that synthetic biology will continue to have broadening impacts on the biotechnology industry to address ongoing issues of human health, world food supply, renewable energy, and industrial chemicals and enzymes.

European research and commercialisation activities in the field of tissue engineering and liver support in world wide competition.

PubMed

Marx, U; Bushnaq, H; Yalcin, E

1998-02-01

Tissue engineering is seen as an interesting field of technology which could improve medical therapy and could also be considered as a commercial opportunity for the European biotechnological industry. Research in the state of the art of science using the MedLine and the Science Citation Index databases, in the patent situation and of the industry dealing with tissue engineering was done. A special method, based on the Science Citation Index Journal Citation Report 1993, for evaluating scientific work was defined. The main countries working in the field of tissue engineering were evaluated in regard to their scientific performance and their patents. The R&D of German industry was investigated as an exemplary European country. Out of all activities, different tissues were rated with respect to the attention received from research and industry and with regard to the frequency in which patents were applied for. USA, Germany and Japan rank first in most tissues, especially liver. After comparing German patents with the German scientific and industrial work, it seems that the potential in German patents and research is underestimated by German industry and inefficiently exploited.

Industrial training approach using GPM P5 Standard for Sustainability in Project Management: a framework for sustainability competencies in the 21st century

NASA Astrophysics Data System (ADS)

Johan, Kartina; Mohd Turan, Faiz

2016-11-01

Malaysian Engineering Accreditation (Engineering Programme Accreditation Manual, 2007) requires all bachelor degree in engineering programmes to incorporate a minimum of two months industrial training in order for the programme to be accredited by the council. The industrial training has the objective to provide students on the insights of being an engineer at the workplace hence increasing their knowledge in employability skills prior to graduation. However the current structure of industrial training is not able to inculcate good leadership ability and prepare students with sustainability competencies needed in the era of Sustainable Development (SD). This paper aims to study project management methodology as a framework to create a training pathway in industrial training for students in engineering programs using Green Project Management (GPM) P5 standard for sustainability in project management. The framework involves students as interns, supervisors from both university and industry and also participation from NonProfit Organisation (NPO). The framework focus on the development of the student's competency in employability skills, lean leadership and sustainability competencies using experiential learning approach. Deliverables of the framework include internship report, professional sustainability report using GPM P5 standard and competency assessment. The post-industrial phase of the framework is constructed for students to be assessed collaboratively by the university, industry and the sustainability practitioner in the country. The ability for the interns to act as a change agent in sustainability practices is measured by the competency assessment and the quality of the sustainability report. The framework support the call for developing holistic students based on Malaysian Education Blueprint (Higher Education) 2015-2025 and address the gap between the statuses of engineering qualification to the sustainability competencies in the 21st century in particular by achieving the Sustainability Graduates (SG) attributes outlined in the framework.

Integrated design optimization research and development in an industrial environment

NASA Astrophysics Data System (ADS)

Kumar, V.; German, Marjorie D.; Lee, S.-J.

1989-04-01

An overview is given of a design optimization project that is in progress at the GE Research and Development Center for the past few years. The objective of this project is to develop a methodology and a software system for design automation and optimization of structural/mechanical components and systems. The effort focuses on research and development issues and also on optimization applications that can be related to real-life industrial design problems. The overall technical approach is based on integration of numerical optimization techniques, finite element methods, CAE and software engineering, and artificial intelligence/expert systems (AI/ES) concepts. The role of each of these engineering technologies in the development of a unified design methodology is illustrated. A software system DESIGN-OPT has been developed for both size and shape optimization of structural components subjected to static as well as dynamic loadings. By integrating this software with an automatic mesh generator, a geometric modeler and an attribute specification computer code, a software module SHAPE-OPT has been developed for shape optimization. Details of these software packages together with their applications to some 2- and 3-dimensional design problems are described.

MEDISIGN: Educating designers for the operating room.

PubMed

Goossens; Lange; Kleinrensink

2004-06-01

One of the interesting things about medical technology is that it addresses so many diverse subjects, which is indeed the case in all departments of a hospital, in general practice and in other care agencies. Medical technology contributes to the diagnosis, treatment and prevention of disease and disorders. Designing for medical applications demands a high level of creativity and inventivity, both in low-tech and in high-tech applications. In over 200 projects with hospitals and companies in the medical field the Delft industrial designer has therefore played an important part in designing innovative products [1]. In the new program Medisign the expertise and networks that have been built up in this area over the past 20 years are being passed on to students. The program is based upon the idea that education of engineers in human anatomy, physiology, medical technoloy, health care systems and even basic surgical techniques will lead to better communication with the medical professionals and to better design solutions in this area. To our knowledge this is the first initiative in Europe in which structural education in anatomy is offered to industrial design engineers.

Integrated design optimization research and development in an industrial environment

NASA Technical Reports Server (NTRS)

Kumar, V.; German, Marjorie D.; Lee, S.-J.

1989-01-01

An overview is given of a design optimization project that is in progress at the GE Research and Development Center for the past few years. The objective of this project is to develop a methodology and a software system for design automation and optimization of structural/mechanical components and systems. The effort focuses on research and development issues and also on optimization applications that can be related to real-life industrial design problems. The overall technical approach is based on integration of numerical optimization techniques, finite element methods, CAE and software engineering, and artificial intelligence/expert systems (AI/ES) concepts. The role of each of these engineering technologies in the development of a unified design methodology is illustrated. A software system DESIGN-OPT has been developed for both size and shape optimization of structural components subjected to static as well as dynamic loadings. By integrating this software with an automatic mesh generator, a geometric modeler and an attribute specification computer code, a software module SHAPE-OPT has been developed for shape optimization. Details of these software packages together with their applications to some 2- and 3-dimensional design problems are described.

26 CFR 1.501(e)-1 - Cooperative hospital service organizations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... illustrated by the following example. Example. An organization performs industrial engineering services on a...-hospitals), warehousing, billing and collection, food, clinical (including radiology), industrial engineering (including the installation, maintenance and repair of biomedical and similar equipment...

26 CFR 1.501(e)-1 - Cooperative hospital service organizations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... illustrated by the following example. Example. An organization performs industrial engineering services on a...-hospitals), warehousing, billing and collection, food, clinical (including radiology), industrial engineering (including the installation, maintenance and repair of biomedical and similar equipment...

26 CFR 1.501(e)-1 - Cooperative hospital service organizations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... illustrated by the following example. Example. An organization performs industrial engineering services on a...-hospitals), warehousing, billing and collection, food, clinical (including radiology), industrial engineering (including the installation, maintenance and repair of biomedical and similar equipment...

26 CFR 1.501(e)-1 - Cooperative hospital service organizations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... illustrated by the following example. Example. An organization performs industrial engineering services on a...-hospitals), warehousing, billing and collection, food, clinical (including radiology), industrial engineering (including the installation, maintenance and repair of biomedical and similar equipment...

26 CFR 1.501(e)-1 - Cooperative hospital service organizations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... illustrated by the following example. Example. An organization performs industrial engineering services on a...-hospitals), warehousing, billing and collection, food, clinical (including radiology), industrial engineering (including the installation, maintenance and repair of biomedical and similar equipment...

75 FR 21043 - Notice of Determinations Terminating Investigations of Petitions Regarding Eligibility To Apply...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

...: Advanced Industrial Machinery, Inc., Hickory, North Carolina, covered by TA-W-70,874: Advanced Industrial...,110: JR Engineering, Barberton, Ohio, covered by TA-W-70,975A: B&C Corporation, JR Engineering...

Careers in the Aerospace Industry.

ERIC Educational Resources Information Center

Federal Aviation Administration (DOT), Washington, DC. Office of General Aviation.

The document briefly presents career information in the field of aerospace industry. Employment exists in three areas: (1) professional and technical occupations in research and development (engineers, scientists, and technicians); (2) administrative, clerical, and related occupations (engineers, scientists, technicians, clerks, secretaries,…

In-Situ Real-Time Focus Detection during Laser Processing Using Double-Hole Masks and Advanced Image Sensor Software

PubMed Central

Hoang, Phuong Le; Ahn, Sanghoon; Kim, Jeng-o; Kang, Heeshin; Noh, Jiwhan

2017-01-01

In modern high-intensity ultrafast laser processing, detecting the focal position of the working laser beam, at which the intensity is the highest and the beam diameter is the lowest, and immediately locating the target sample at that point are challenging tasks. A system that allows in-situ real-time focus determination and fabrication using a high-power laser has been in high demand among both engineers and scientists. Conventional techniques require the complicated mathematical theory of wave optics, employing interference as well as diffraction phenomena to detect the focal position; however, these methods are ineffective and expensive for industrial application. Moreover, these techniques could not perform detection and fabrication simultaneously. In this paper, we propose an optical design capable of detecting the focal point and fabricating complex patterns on a planar sample surface simultaneously. In-situ real-time focus detection is performed using a bandpass filter, which only allows for the detection of laser transmission. The technique enables rapid, non-destructive, and precise detection of the focal point. Furthermore, it is sufficiently simple for application in both science and industry for mass production, and it is expected to contribute to the next generation of laser equipment, which can be used to fabricate micro-patterns with high complexity. PMID:28671566

Engineering Students' Views of Corporate Social Responsibility: A Case Study from Petroleum Engineering.

PubMed

Smith, Jessica M; McClelland, Carrie J; Smith, Nicole M

2017-12-01

The mining and energy industries present unique challenges to engineers, who must navigate sometimes competing responsibilities and codes of conduct, such as personal senses of right and wrong, professional ethics codes, and their employers' corporate social responsibility (CSR) policies. Corporate social responsibility (CSR) is the current dominant framework used by industry to conceptualize firms' responsibilities to their stakeholders, yet has it plays a relatively minor role in engineering ethics education. In this article, we report on an interdisciplinary pedagogical intervention in a petroleum engineering seminar that sought to better prepare engineering undergraduate students to critically appraise the strengths and limitations of CSR as an approach to reconciling the interests of industry and communities. We find that as a result of the curricular interventions, engineering students were able to expand their knowledge of the social, rather than simply environmental and economic dimensions of CSR. They remained hesitant, however, in identifying the links between those social aspects of CSR and their actual engineering work. The study suggests that CSR may be a fruitful arena from which to illustrate the profoundly sociotechnical dimensions of the engineering challenges relevant to students' future careers.

Incorporating comparative genomics into the design-test-learn cycle of microbial strain engineering.

PubMed

Sardi, Maria; Gasch, Audrey P

2017-08-01

Engineering microbes with new properties is an important goal in industrial engineering, to establish biological factories for production of biofuels, commodity chemicals and pharmaceutics. But engineering microbes to produce new compounds with high yield remains a major challenge toward economically viable production. Incorporating several modern approaches, including synthetic and systems biology, metabolic modeling and regulatory rewiring, has proven to significantly advance industrial strain engineering. This review highlights how comparative genomics can also facilitate strain engineering, by identifying novel genes and pathways, regulatory mechanisms and genetic background effects for engineering. We discuss how incorporating comparative genomics into the design-test-learn cycle of strain engineering can provide novel information that complements other engineering strategies. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Digital Image Analysis Algorithm For Determination of Particle Size Distributions In Diesel Engines

NASA Astrophysics Data System (ADS)

Armas, O.; Ballesteros, R.; Gomez, A.

One of the most serious problems associated to Diesel engines is pollutant emissions, standing out nitrogen oxides and particulate matter. However, although current emis- sions standards in Europe and America with regard to light vehicles and heavy duty engines refer the particulate limit in mass units, concern for knowing size and number of particles emitted by engines is being increased recently. This interest is promoted by last studies about particle harmful effects on health and is enhanced by recent changes in internal combustion engines technology. This study is focused on the implementation of a method to determine the particle size distribution made up in current methodology for vehicles certification in Europe. It will use an automated Digital Image Analysis Algorithm (DIAA) to determine particle size trends from Scanning Electron Microscope (SEM) images of filters charged in a dilution system used for measuring specific particulate emissions. The experimental work was performed on a steady state direct injection Diesel en- gine with 0.5 MW rated power, being considered as a typical engine in middle power industries. Particulate size distributions obtained using DIAA and a Scanning Mobil- ity Particle Sizer (SMPS), nowadays considered as the most reliable technique, were compared. Although number concentration detected by this method does not repre- sent real flowing particle concentration, this algorithm fairly reproduces the trends observed with SMPS when the engine load is varied.

Full hoop casing for midframe of industrial gas turbine engine

DOEpatents

Myers, Gerald A.; Charron, Richard C.

2015-12-01

A can annular industrial gas turbine engine, including: a single-piece rotor shaft spanning a compressor section (82), a combustion section (84), a turbine section (86); and a combustion section casing (10) having a section (28) configured as a full hoop. When the combustion section casing is detached from the engine and moved to a maintenance position to allow access to an interior of the engine, a positioning jig (98) is used to support the compressor section casing (83) and turbine section casing (87).

Design of the subject of quality engineering and security of the product of the degree in engineering in industrial design and development of product based in the methodology of the case

NASA Astrophysics Data System (ADS)

González, M. R.; Lambán, M. P.

2012-04-01

This paper presents the result of designing the subject Quality Engineering and Security of the Product, belonging to the Degree of Engineering in Industrial Design and Product Development, on the basis of the case methodology. Practical sessions of this subject are organized using the whole documents of the Quality System Management of the virtual company BeaLuc S.A.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klipstein, David H.; Robinson, Sharon

The Reaction Engineering Roadmap is a part of an industry- wide effort to create a blueprint of the research and technology milestones that are necessary to achieve longterm industry goals. This report documents the results of a workshop focused on the research needs, technology barriers, and priorities of the chemical industry as they relate to reaction engineering viewed first by industrial use (basic chemicals; specialty chemicals; pharmaceuticals; and polymers) and then by technology segment (reactor system selection, design, and scale-up; chemical mechanism development and property estimation; dealing with catalysis; and new, nonstandard reactor types).

The Study on Neuro-IE Management Software in Manufacturing Enterprises. -The Application of Video Analysis Technology

NASA Astrophysics Data System (ADS)

Bian, Jun; Fu, Huijian; Shang, Qian; Zhou, Xiangyang; Ma, Qingguo

This paper analyzes the outstanding problems in current industrial production by reviewing the three stages of the Industrial Engineering Development. Based on investigations and interviews in enterprises, we propose the new idea of applying "computer video analysis technology" to new industrial engineering management software, and add "loose-coefficient" of the working station to this software in order to arrange scientific and humanistic production. Meanwhile, we suggest utilizing Biofeedback Technology to promote further research on "the rules of workers' physiological, psychological and emotional changes in production". This new kind of combination will push forward industrial engineering theories and benefit enterprises in progressing towards flexible social production, thus it will be of great theory innovation value, social significance and application value.

Clean Air Act Standards and Guidelines for Energy, Engines, and Combustion

EPA Pesticide Factsheets

This page contains the stationary sources of air pollution for the energy, engines, and combustion industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

Job Prospects for Industrial Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1985-01-01

Recent economic growth and improved manufacturing profitability are supporting increased employment for industrial engineers. Promising areas include modernizing manufacturing technology and productivity with large amounts of hiring in aerospace, electronics, and instrumentation. Percentages of women employed in these fields for 1982 and 1983 are…

Chemists, Engineers Probe Mutual Problems.

ERIC Educational Resources Information Center

Chemical and Engineering News, 1980

1980-01-01

Summarizes recommendations made in a workshop sponsored by the American Chemical Society concerning issues involving the diverging viewpoints of chemistry and chemical engineering. Includes recommendations regarding curricula, salary differences, and the need to change attitudes of chemistry faculty toward industry and industrial chemistry. (CS)

Profiles of Automotive Suppliers Industries--Engineered Mechanical Components and Systems : Volume I, Text.

DOT National Transportation Integrated Search

1981-09-01

This profile describes and analyzes that segment of the automotive supplier industry which provides engineered mechanical components/assemblies/systems to the prime auto manufacturers. It presents an overview of the role and structure of this industr...

Engineered Plants Make Potential Precursor to Raw Material for Plastics

ScienceCinema

Shanklin, John

2018-06-12

In a first step toward achieving industrial-scale green production, scientists from BNL and collaborators at Dow AgroSciences report engineering a plant that produces industrially relevant levels of chemicals that could potentially be used to make plastics.

The Advanced Software Development and Commercialization Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallopoulos, E.; Canfield, T.R.; Minkoff, M.

1990-09-01

This is the first of a series of reports pertaining to progress in the Advanced Software Development and Commercialization Project, a joint collaborative effort between the Center for Supercomputing Research and Development of the University of Illinois and the Computing and Telecommunications Division of Argonne National Laboratory. The purpose of this work is to apply techniques of parallel computing that were pioneered by University of Illinois researchers to mature computational fluid dynamics (CFD) and structural dynamics (SD) computer codes developed at Argonne. The collaboration in this project will bring this unique combination of expertise to bear, for the first time,more » on industrially important problems. By so doing, it will expose the strengths and weaknesses of existing techniques for parallelizing programs and will identify those problems that need to be solved in order to enable wide spread production use of parallel computers. Secondly, the increased efficiency of the CFD and SD codes themselves will enable the simulation of larger, more accurate engineering models that involve fluid and structural dynamics. In order to realize the above two goals, we are considering two production codes that have been developed at ANL and are widely used by both industry and Universities. These are COMMIX and WHAMS-3D. The first is a computational fluid dynamics code that is used for both nuclear reactor design and safety and as a design tool for the casting industry. The second is a three-dimensional structural dynamics code used in nuclear reactor safety as well as crashworthiness studies. These codes are currently available for both sequential and vector computers only. Our main goal is to port and optimize these two codes on shared memory multiprocessors. In so doing, we shall establish a process that can be followed in optimizing other sequential or vector engineering codes for parallel processors.« less

Near-field Light Scattering Techniques for Measuring Nanoparticle-Surface Interaction Energies and Forces.

PubMed

Schein, Perry; Ashcroft, Colby K; O'Dell, Dakota; Adam, Ian S; DiPaolo, Brian; Sabharwal, Manit; Shi, Ce; Hart, Robert; Earhart, Christopher; Erickson, David

2015-08-15

Nanoparticles are quickly becoming commonplace in many commercial and industrial products, ranging from cosmetics to pharmaceuticals to medical diagnostics. Predicting the stability of the engineered nanoparticles within these products a priori remains an important and difficult challenge. Here we describe our techniques for measuring the mechanical interactions between nanoparticles and surfaces using near-field light scattering. Particle-surface interfacial forces are measured by optically "pushing" a particle against a reference surface and observing its motion using scattered near-field light. Unlike atomic force microscopy, this technique is not limited by thermal noise, but instead takes advantage of it. The integrated waveguide and microfluidic architecture allow for high-throughput measurements of about 1000 particles per hour. We characterize the reproducibility of and experimental uncertainty in the measurements made using the NanoTweezer surface instrument. We report surface interaction studies on gold nanoparticles with 50 nm diameters, smaller than previously reported in the literature using similar techniques.

Towards a balanced software team formation based on Belbin team role using fuzzy technique

NASA Astrophysics Data System (ADS)

Omar, Mazni; Hasan, Bikhtiyar; Ahmad, Mazida; Yasin, Azman; Baharom, Fauziah; Mohd, Haslina; Darus, Norida Muhd

2016-08-01

In software engineering (SE), team roles play significant impact in determining the project success. To ensure the optimal outcome of the project the team is working on, it is essential to ensure that the team members are assigned to the right role with the right characteristics. One of the prevalent team roles is Belbin team role. A successful team must have a balance of team roles. Thus, this study demonstrates steps taken to determine balance of software team formation based on Belbin team role using fuzzy technique. Fuzzy technique was chosen because it allows analyzing of imprecise data and classifying selected criteria. In this study, two roles in Belbin team role, which are Shaper (Sh) and Plant (Pl) were chosen to assign the specific role in software team. Results show that the technique is able to be used for determining the balance of team roles. Future works will focus on the validation of the proposed method by using empirical data in industrial setting.

Roadmap to the Future

NASA Astrophysics Data System (ADS)

Colby, Eric R.; Len, L. K.

Most particle accelerators today are expensive devices found only in the largest laboratories, industries, and hospitals. Using techniques developed nearly a century ago, the limiting performance of these accelerators is often traceable to material limitations, power source capabilities, and the cost tolerance of the application. Advanced accelerator concepts aim to increase the gradient of accelerators by orders of magnitude, using new power sources (e.g. lasers and relativistic beams) and new materials (e.g. dielectrics, metamaterials, and plasmas). Worldwide, research in this area has grown steadily in intensity since the 1980s, resulting in demonstrations of accelerating gradients that are orders of magnitude higher than for conventional techniques. While research is still in the early stages, these techniques have begun to demonstrate the potential to radically change accelerators, making them much more compact, and extending the reach of these tools of science into the angstrom and attosecond realms. Maturation of these techniques into robust, engineered devices will require sustained interdisciplinary, collaborative R&D and coherent use of test infrastructure worldwide. The outcome can potentially transform how accelerators are used.

Roadmap to the Future

NASA Astrophysics Data System (ADS)

Colby, Eric R.; Len, L. K.

Most particle accelerators today are expensive devices found only in the largest laboratories, industries, and hospitals. Using techniques developed nearly a century ago, the limiting performance of these accelerators is often traceable to material limitations, power source capabilities, and the cost tolerance of the application. Advanced accelerator conceptsa aim to increase the gradient of accelerators by orders of magnitude, using new power sources (e.g. lasers and relativistic beams) and new materials (e.g. dielectrics, metamaterials, and plasmas). Worldwide, research in this area has grown steadily in intensity since the 1980s, resulting in demonstrations of accelerating gradients that are orders of magnitude higher than for conventional techniques. While research is still in the early stages, these techniques have begun to demonstrate the potential to radically change accelerators, making them much more compact, and extending the reach of these tools of science into the angstrom and attosecond realms. Maturation of these techniques into robust, engineered devices will require sustained interdisciplinary, collaborative R&D and coherent use of test infrastructure worldwide. The outcome can potentially transform how accelerators are used.

The Exploration and Practice of Gradually Industrialization Model in Software Engineering Education: A Factual Instance of the Excellent Engineer Plan of China

ERIC Educational Resources Information Center

Liu, Shu; Ma, Peijun; Li, Dong

2012-01-01

The current education model and practices in the Higher education sector in China have been successful in educating students for academic excellence, for producing industry-linked and practice-oriented graduates, who could quickly fit into the industrial working environment, has been a problem. There is a big gap between the theoretical knowledge…

Competency Focused Engineering Education with Reference to IT Related Disciplines: Is the Indian System Ready for Transformation?

ERIC Educational Resources Information Center

Goel, Sanjay

2006-01-01

The growth of the Indian IT industry has been of great interest to the international IT community. Nearly one third of fresh Indian engineering graduates are currently joining the IT industry irrespective of their specialization. The success of the Indian IT industry, however, has not been yet been leveraged for developing India as a preferred…

Development of Iron Aluminides.

DTIC Science & Technology

1986-03-01

in the evolution of technology for the aerospace industry. This is particularly true for the gas turbine engine industry, where the requirements for...vulnerability of the U.S. gas turbine industry in terms of its heavy reliance upon non-domestic sources for much of its strategic metals requirements...superalloys used in gas turbine engines. The questionable future availability of chromium, for example, poses a potential serious threat to these applicacions

Evaluation of Project Based Learning in the Area of Manufacturing and Statistics in the Degree of Industrial Technology

ERIC Educational Resources Information Center

Buj-Corral, Irene; Marco-Almagro, Lluís; Riba, Alex; Vivancos-Calvet, Joan; Tort-Martorell, Xavier

2015-01-01

In the subject Project I in the second year of the Degree in Industrial Technology Engineering taught at the School of Industrial Engineering of Barcelona (ETSEIB), subgroups of 3-4 students within groups of 20 students develop a project along a semester. Results of 2 projects are presented related to manufacturing, measurement of parts and the…

Competitive Tradeoff Modeling: Methodology, Computation, and Testing

DTIC Science & Technology

1997-12-01

variational inequalities produced the dissertation of Ozge [4], which presented and justified a new method for numerical solution of stochastic...Philosophy (Industrial Engineering) in 1996. • A. Yonca Ozge , Research Assistant. Ms. Ozge received the degree of Doctor of Philosophy (Industrial...Ph.D. Disserta- tion, Department of Industrial Engineering, University of Wisconsin- Madison, 1996. [2] G. Gürkan, A. Y. Ozge , and S. M. Robinson

Ceramic regenerator systems development program

NASA Technical Reports Server (NTRS)

Cook, J. A.; Fucinari, C. A.; Lingscheit, J. N.; Rahnke, C. J.; Rao, V. D.

1978-01-01

Ceramic regenerator cores are considered that can be used in passenger car gas turbine engines, Stirling engines, and industrial/truck gas turbine engines. Improved materials and design concepts aimed at reducing or eliminating chemical attack were placed on durability tests/in industrial gas turbine engines. A regenerator core made from aluminum silicate shows minimal evidence of chemical attack damage after 7804 hours of engine test at 800 C and another showed little distress after 4983 hours at 982 C. The results obtained in ceramic material screening tests, aerothermodynamic performance tests, stress analysis, cost studies, and material specifications are also included.

What are the Limitations of Enzymes in Synthetic Organic Chemistry?

PubMed

Reetz, Manfred T

2016-12-01

Enzymes have been used in organic chemistry and biotechnology for 100 years, but their widespread application has been prevented by a number of limitations, including the often-observed limited thermostability, narrow substrate scope, and low or wrong stereo- and/or regioselectivity. Directed evolution provides a means to address and generally solve these problems, especially since recent methodology development has made this protein engineering method faster, more efficient, and more reliable than in the past. This Darwinian approach to asymmetric catalysis has led to a number of industrial applications. Metabolic-pathway engineering, mutasynthesis, and fermentation are likewise enzyme-based techniques that enrich chemistry. This account outlines the scope, and particularly, the limitations, of biocatalysis. The complementary nature of enzymes and man-made catalysts is emphasized. © 2016 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

ECUT: Energy Conversion and Utilization Technologies program - Biocatalysis research activity

NASA Technical Reports Server (NTRS)

Wilcox, R.

1984-01-01

The activities of the Biocatalysis Research Activity are organized into the Biocatalysis and Molecular Modeling work elements and a supporting planning and analysis function. In the Biocatalysis work element, progress is made in developing a method for stabilizing genetically engineered traits in microorganisms, refining a technique for monitoring cells that are genetically engineered, and identifying strains of fungi for highly efficient preprocessing of biomass for optimizing the efficiency of bioreactors. In the Molecular Modeling work element, a preliminary model of the behavior of enzymes is developed. A preliminary investigation of the potential for synthesizing enzymes for use in electrochemical processes is completed. Contact with industry and universities is made to define key biocatalysis technical issues and to broaden the range of potential participants in the activity. Analyses are conducted to identify and evaluate potential concepts for future research funding.

Advanced computational tools for 3-D seismic analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barhen, J.; Glover, C.W.; Protopopescu, V.A.

1996-06-01

The global objective of this effort is to develop advanced computational tools for 3-D seismic analysis, and test the products using a model dataset developed under the joint aegis of the United States` Society of Exploration Geophysicists (SEG) and the European Association of Exploration Geophysicists (EAEG). The goal is to enhance the value to the oil industry of the SEG/EAEG modeling project, carried out with US Department of Energy (DOE) funding in FY` 93-95. The primary objective of the ORNL Center for Engineering Systems Advanced Research (CESAR) is to spearhead the computational innovations techniques that would enable a revolutionary advancemore » in 3-D seismic analysis. The CESAR effort is carried out in collaboration with world-class domain experts from leading universities, and in close coordination with other national laboratories and oil industry partners.« less

Biological conversion of carbon dioxide and hydrogen into liquid fuels and industrial chemicals.

PubMed

Hawkins, Aaron S; McTernan, Patrick M; Lian, Hong; Kelly, Robert M; Adams, Michael W W

2013-06-01

Non-photosynthetic routes for biological fixation of carbon dioxide into valuable industrial chemical precursors and fuels are moving from concept to reality. The development of 'electrofuel'-producing microorganisms leverages techniques in synthetic biology, genetic and metabolic engineering, as well as systems-level multi-omic analysis, directed evolution, and in silico modeling. Electrofuel processes are being developed for a range of microorganisms and energy sources (e.g. hydrogen, formate, electricity) to produce a variety of target molecules (e.g. alcohols, terpenes, alkenes). This review examines the current landscape of electrofuel projects with a focus on hydrogen-utilizing organisms covering the biochemistry of hydrogenases and carbonic anhydrases, kinetic and energetic analyses of the known carbon fixation pathways, and the state of genetic systems for current and prospective electrofuel-producing microorganisms. Copyright © 2013 Elsevier Ltd. All rights reserved.

A systems biology perspective of wine fermentations.

PubMed

Pizarro, Francisco; Vargas, Felipe A; Agosin, Eduardo

2007-11-01

The yeast Saccharomyces cerevisiae is an important industrial microorganism. Nowadays, it is being used as a cell factory for the production of pharmaceuticals such as insulin, although this yeast has long been utilized in the bakery to raise dough, and in the production of alcoholic beverages, fermenting the sugars derived from rice, wheat, barley, corn and grape juice. S. cerevisiae has also been extensively used as a model eukaryotic system. In the last decade, genomic techniques have revealed important features of its molecular biology. For example, DNA array technologies are routinely used for determining gene expression levels in cells under different physiological conditions or environmental stimuli. Laboratory strains of S. cerevisiae are different from wine strains. For instance, laboratory yeasts are unable to completely transform all the sugar in the grape must into ethanol under winemaking conditions. In fact, standard culture conditions are usually very different from winemaking conditions, where multiple stresses occur simultaneously and sequentially throughout the fermentation. The response of wine yeasts to these stimuli differs in some aspects from laboratory strains, as suggested by the increasing number of studies in functional genomics being conducted on wine strains. In this paper we review the most recent applications of post-genomic techniques to understand yeast physiology in the wine industry. We also report recent advances in wine yeast strain improvement and propose a reference framework for integration of genomic information, bioinformatic tools and molecular biology techniques for cellular and metabolic engineering. Finally, we discuss the current state and future perspectives for using 'modern' biotechnology in the wine industry.

Education, Technology, and Media: A Peak into My Summer Internship at NASA Glenn Research Center in Cleveland, Ohio

NASA Technical Reports Server (NTRS)

Moon, James

2004-01-01

My name is James Moon and I am a senor at Tennessee State University where my major is Aeronautical and Industrial Technology with a concentration in industrial electronics. I am currently serving my internship in the Engineering and Technical Services Directorate at the Glenn Research Center (GRC). The Engineering and Technical Service Directorate provides the services and infrastructure for the Glenn Research Center to take research concepts to reality. They provide a full range of integrated services including engineering, advanced prototyping and testing, facility management, and information technology for NASA, industry, and academia. Engineering and Technical Services contains the core knowledge in Information Technology (IT). This includes data systems and analysis, inter and intranet based systems design and data security. Including the design and development of embedded real-time sohare applications for flight and supporting ground systems, Engineering and Technical Services provide a wide range of IT services and products specific to the Glenn Research Center research and engineering community.

Dedicated Industrial Oilseed Crops as Metabolic Engineering Platforms for Sustainable Industrial Feedstock Production

PubMed Central

Zhu, Li-Hua; Krens, Frans; Smith, Mark A.; Li, Xueyuan; Qi, Weicong; van Loo, Eibertus N.; Iven, Tim; Feussner, Ivo; Nazarenus, Tara J.; Huai, Dongxin; Taylor, David C.; Zhou, Xue-Rong; Green, Allan G.; Shockey, Jay; Klasson, K. Thomas; Mullen, Robert T.; Huang, Bangquan; Dyer, John M.; Cahoon, Edgar B.

2016-01-01

Feedstocks for industrial applications ranging from polymers to lubricants are largely derived from petroleum, a non-renewable resource. Vegetable oils with fatty acid structures and storage forms tailored for specific industrial uses offer renewable and potentially sustainable sources of petrochemical-type functionalities. A wide array of industrial vegetable oils can be generated through biotechnology, but will likely require non-commodity oilseed platforms dedicated to specialty oil production for commercial acceptance. Here we show the feasibility of three Brassicaceae oilseeds crambe, camelina, and carinata, none of which are widely cultivated for food use, as hosts for complex metabolic engineering of wax esters for lubricant applications. Lines producing wax esters >20% of total seed oil were generated for each crop and further improved for high temperature oxidative stability by down-regulation of fatty acid polyunsaturation. Field cultivation of optimized wax ester-producing crambe demonstrated commercial utility of these engineered crops and a path for sustainable production of other industrial oils in dedicated specialty oilseeds. PMID:26916792

Dedicated Industrial Oilseed Crops as Metabolic Engineering Platforms for Sustainable Industrial Feedstock Production.

PubMed

Zhu, Li-Hua; Krens, Frans; Smith, Mark A; Li, Xueyuan; Qi, Weicong; van Loo, Eibertus N; Iven, Tim; Feussner, Ivo; Nazarenus, Tara J; Huai, Dongxin; Taylor, David C; Zhou, Xue-Rong; Green, Allan G; Shockey, Jay; Klasson, K Thomas; Mullen, Robert T; Huang, Bangquan; Dyer, John M; Cahoon, Edgar B

2016-02-26

Feedstocks for industrial applications ranging from polymers to lubricants are largely derived from petroleum, a non-renewable resource. Vegetable oils with fatty acid structures and storage forms tailored for specific industrial uses offer renewable and potentially sustainable sources of petrochemical-type functionalities. A wide array of industrial vegetable oils can be generated through biotechnology, but will likely require non-commodity oilseed platforms dedicated to specialty oil production for commercial acceptance. Here we show the feasibility of three Brassicaceae oilseeds crambe, camelina, and carinata, none of which are widely cultivated for food use, as hosts for complex metabolic engineering of wax esters for lubricant applications. Lines producing wax esters >20% of total seed oil were generated for each crop and further improved for high temperature oxidative stability by down-regulation of fatty acid polyunsaturation. Field cultivation of optimized wax ester-producing crambe demonstrated commercial utility of these engineered crops and a path for sustainable production of other industrial oils in dedicated specialty oilseeds.

Engineering and public health at CDC.

PubMed

Earnest, G Scott; Reed, Laurence D; Conover, D; Estill, C; Gjessing, C; Gressel, M; Hall, R; Hudock, S; Hudson, H; Kardous, C; Sheehy, J; Topmiller, J; Trout, D; Woebkenberg, M; Amendola, A; Hsiao, H; Keane, P; Weissman, D; Finfinger, G; Tadolini, S; Thimons, E; Cullen, E; Jenkins, M; McKibbin, R; Conway, G; Husberg, B; Lincoln, J; Rodenbeck, S; Lantagne, D; Cardarelli, J

2006-12-22

Engineering is the application of scientific and technical knowledge to solve human problems. Using imagination, judgment, and reasoning to apply science, technology, mathematics, and practical experience, engineers develop the design, production, and operation of useful objects or processes. During the 1940s, engineers dominated the ranks of CDC scientists. In fact, the first CDC director, Assistant Surgeon General Mark Hollis, was an engineer. CDC engineers were involved in malaria control through the elimination of standing water. Eventually the CDC mission expanded to include prevention and control of dengue, typhus, and other communicable diseases. The development of chlorination, water filtration, and sewage treatment were crucial to preventing waterborne illness. Beginning in the 1950s, CDC engineers began their work to improve public health while developing the fields of environmental health, industrial hygiene, and control of air pollution. Engineering disciplines represented at CDC today include biomedical, civil, chemical, electrical, industrial, mechanical, mining, and safety engineering. Most CDC engineers are located in the National Institute for Occupational Safety and Health (NIOSH) and the Agency for Toxic Substances and Disease Registry (ATSDR). Engineering research at CDC has a broad stakeholder base. With the cooperation of industry, labor, trade associations, and other stakeholders and partners, current work includes studies of air contaminants, mining, safety, physical agents, ergonomics, and environmental hazards. Engineering solutions remain a cornerstone of the traditional "hierarchy of controls" approach to reducing public health hazards.

Development and Hot-fire Testing of Additively Manufactured Copper Combustion Chambers for Liquid Rocket Engine Applications

NASA Technical Reports Server (NTRS)

Gradl, Paul R.; Greene, Sandy Elam; Protz, Christopher S.; Ellis, David L.; Lerch, Bradley A.; Locci, Ivan E.

2017-01-01

NASA and industry partners are working towards fabrication process development to reduce costs and schedules associated with manufacturing liquid rocket engine components with the goal of reducing overall mission costs. One such technique being evaluated is powder-bed fusion or selective laser melting (SLM), commonly referred to as additive manufacturing (AM). The NASA Low Cost Upper Stage Propulsion (LCUSP) program was designed to develop processes and material characterization for GRCop-84 (a NASA Glenn Research Center-developed copper, chrome, niobium alloy) commensurate with powder-bed AM, evaluate bimetallic deposition, and complete testing of a full scale combustion chamber. As part of this development, the process has been transferred to industry partners to enable a long-term supply chain of monolithic copper combustion chambers. To advance the processes further and allow for optimization with multiple materials, NASA is also investigating the feasibility of bimetallic AM chambers. In addition to the LCUSP program, NASA has completed a series of development programs and hot-fire tests to demonstrate SLM GRCop-84 and other AM techniques. NASA's efforts include a 4K lbf thrust liquid oxygen/methane (LOX/CH4) combustion chamber and subscale thrust chambers for 1.2K lbf LOX/hydrogen (H2) applications that have been designed and fabricated with SLM GRCop-84. The same technologies for these lower thrust applications are being applied to 25-35K lbf main combustion chamber (MCC) designs. This paper describes the design, development, manufacturing and testing of these numerous combustion chambers, and the associated lessons learned throughout their design and development processes.

Allison moving forward

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raflo, D.

1994-07-01

Allison has been on its own since December 1, when General Motors Corporation sold its former Allison Gas Turbine Division to Clayton, Dubilier & Rice Inc, a private New York investment firm, and a group of senior Allison managers for $318 million. Allison engine Company`s current product line includes large engines, small aircraft engines, and industrial engines. Over 140,000 engines have been produced since 1915, giving Allison a large stake in world leaderhsip. With strong cogeneration markets already established in Europe and Japan, Allison`s industrial engines are being positioned to compete in emerging markets in China, Indonesia and the Sovietmore » Union. Cogeneration market potential in the US improves despite the current popularity with abundant, low-cost natural gas because of the South Coast Air Control Management District`s push for reduced emissions. The new 7000-shp KB7 industrial engine is the latest addition to the 501K engine family, and adds increased power (by 1700 shp), with a boost compressor to the current core compressor increasing air flow, along with a new low-loss exhaust system. Allison`s new AE series of turboprop (AE 2100) and turbofan (AE 3007) engines, with engine cores derived from the T406 design, have been selected to power regional airliners. 2 figs.« less

Industry Partners at CBE

Science.gov Websites

* Charles M. Salter Associates DIALOG HGA Architects and Engineers HOK Integral Group Interface Engineering + Will SERA Architects Taylor Engineering Team: Atelier Ten Taylor Engineering TRC Energy Services

Theory and Practice Meets in Industrial Process Design -Educational Perspective-

NASA Astrophysics Data System (ADS)

Aramo-Immonen, Heli; Toikka, Tarja

Software engineer should see himself as a business process designer in enterprise resource planning system (ERP) re-engineering project. Software engineers and managers should have design dialogue. The objective of this paper is to discuss the motives to study the design research in connection of management education in order to envision and understand the soft human issues in the management context. Second goal is to develop means of practicing social skills between designers and managers. This article explores the affective components of design thinking in industrial management domain. In the conceptual part of this paper are discussed concepts of network and project economy, creativity, communication, use of metaphors, and design thinking. Finally is introduced empirical research plan and first empirical results from design method experiments among the multi-disciplined groups of the master-level students of industrial engineering and management and software engineering.

Assessing the Higher National Diploma Chemical Engineering programme in Ghana: students' perspective

NASA Astrophysics Data System (ADS)

Boateng, Cyril D.; Cudjoe Bensah, Edem; Ahiekpor, Julius C.

2012-05-01

Chemical engineers have played key roles in the growth of the chemical and allied industries in Ghana but indigenous industries that have traditionally been the domain of the informal sector need to be migrated to the formal sector through the entrepreneurship and innovation of chemical engineers. The Higher National Diploma Chemical Engineering programme is being migrated from a subject-based to a competency-based curriculum. This paper evaluates the programme from the point of view of students. Data were drawn from a survey conducted in the department and were analysed using SPSS. The survey involved administering questionnaires to students at all levels in the department. Analysis of the responses indicated that the majority of the students had decided to pursue chemical engineering due to the career opportunities available. Their knowledge of the programme learning outcomes was, however, poor. The study revealed that none of the students was interested in developing indigenous industries.

Development of Graduate Course Education by Industry Collaboration in Center for Engineering Education Development, CEED

NASA Astrophysics Data System (ADS)

Noguchi, Toru; Yoshikawa, Kozo; Nakamura, Masato; Kaneko, Katsuhiko

New education programs for engineering graduate courses, and the achievements are described. Following the previous reports on overseas and domestic internship2) , 3) , this article states other common programs ; seminars on state of technologies in industries, practical English and internationalization programs, and a program to accept overseas internship students. E-learning system to assist off-campus students is also described. All these programs are developed and conducted by specialist professors invited from industries and national institutions, in collaboration with faculty professors. Students learn how the engineering science apply to the practical problems, acquire wider view and deeper understanding on industries, and gain abilities to act in global society including communication skill, those are not taught in classrooms and laboratories. Educational effects of these industry collaborated programs is significant to activate the graduate course education, although the comprehensive evaluation is the future subject.

Innovative Ways of Teaching Polymerization Reaction Engineering: Exchanging Information between the University and Industry.

ERIC Educational Resources Information Center

Soares, Joao B. P.; Penlidis, Alexander; Hamielec, Archie E.

1998-01-01

Describes how interaction with several polymer manufacturing companies through industrial short courses and research projects has led to the development of dynamic and up-to-date undergraduate and graduate curriculums in polymer science and engineering technology. (DDR)

Enhanced Learning from an Industry-University Partnership. Aluminum Engineering Course Design and Development.

ERIC Educational Resources Information Center

Pai, Devdas M.; DeBlasio, Richard A.

1997-01-01

The example of Alcoa and North Carolina State University shows that partnerships in course design, development, and delivery can result in an engineering curriculum that bridges theory and practice and makes students aware of industry expectations. (SK)

75 FR 8316 - Office of Postsecondary Education; Overview Information; Erma Byrd Scholarship Program; Notice...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... Transmittal of Applications: March 26, 2010. Full Text of Announcement I. Funding Opportunity Description... related to industrial health and safety: Mining and mineral engineering, industrial engineering... technology/technician, hazardous materials information systems technology/technician, mining technology...

29 CFR 1926.602 - Material handling equipment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Engineers J333a-1970, Operator Protection for Agricultural and Light Industrial Tractors. (ii) Seat belts... wheel tractors, bulldozers, off-highway trucks, graders, agricultural and industrial tractors, and... Society of Automotive Engineers, J386-1969, Seat Belts for Construction Equipment. Seat belts for...

29 CFR 1926.602 - Material handling equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Engineers J333a-1970, Operator Protection for Agricultural and Light Industrial Tractors. (ii) Seat belts... wheel tractors, bulldozers, off-highway trucks, graders, agricultural and industrial tractors, and... Society of Automotive Engineers, J386-1969, Seat Belts for Construction Equipment. Seat belts for...

Acoustics: A branch of engineering at the Universidad Austral de Chile (UACh)

NASA Astrophysics Data System (ADS)

Poblete, Victor; Arenas, Jorge P.; Sommerhoff, Jorge

2002-11-01

At the end of the 1960s, the first acousticians graduating at UACh had acquired an education in applied physics and musical arts, since there was no College of Engineering at that time. Initially, they had a (rather modest) four-year undergraduate program, and most of the faculty were not specialized teachers. The graduates from such a program received a sound engineering degree and they were skilled for jobs in the musical industry and sound reinforcement companies. In addition, they worked as sound engineers and producers. Later, because of the scientific, industrial and educational changes in Chile during the 1980s, the higher education system had massive changes that affected all of the undergraduate and graduate programs of the 61 universities in Chile. The UACh College of Engineering was officially founded in 1989. Then, acoustics as an area of expertise was included, widened and developed as an interdisciplinary subject. Currently, the undergraduate program in acoustics at UACh offers a degree in engineering sciences and a 6-year professional studies in Civil Engineering (Acoustics), having two main fields: Sound and Image, and Environment and Industry.

Master of Engineering Energy Systems Engineering Program: Smart Campus Energy Systems Demonstration DE-SC0005523

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dodge, Martha; Coulter, John

2014-09-25

Program Purpose and Position: The mission of the Master of Engineering in Energy Systems Engineering program is to invigorate the pipeline of new engineering graduates interested in energy oriented careers and thus produce a new generation of technical leaders for the energy and power industries. Over the next decade, nearly 50% of the skilled workers and technical leaders in the gas and electric utility industries will retire -- a much larger void than the current available and qualified professionals could fill [CEWD, 2012 survey]. The Masters of Engineering in Energy System Engineering program provides an opportunity for cross-discipline education formore » graduates interested in a career in the energy industry. It focuses on electric power and the challenges and opportunities to develop a sustainable, reliable and resilient system that meets human needs in an increasingly sustainable manner through the use of environmentally sound energy resources and delivery. Both graduates and employers benefit from a well-trained professional workforce that is ready to hit the road running and be immediately productive in meeting these challenges, through this innovative and unique program.« less

Pahoa geothermal industrial park. Engineering and economic analysis for direct applications of geothermal energy in an industrial park at Pahoa, Hawaii

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreau, J.W.

1980-12-01

This engineering and economic study evaluated the potential for developing a geothermal industrial park in the Puna District near Pahoa on the Island of Hawaii. Direct heat industrial applications were analyzed from a marketing, engineering, economic, environmental, and sociological standpoint to determine the most viable industries for the park. An extensive literature search produced 31 existing processes currently using geothermal heat. An additional list was compiled indicating industrial processes that require heat that could be provided by geothermal energy. From this information, 17 possible processes were selected for consideration. Careful scrutiny and analysis of these 17 processes revealed three thatmore » justified detailed economic workups. The three processes chosen for detailed analysis were: an ethanol plant using bagasse and wood as feedstock; a cattle feed mill using sugar cane leaf trash as feedstock; and a papaya processing facility providing both fresh and processed fruit. In addition, a research facility to assess and develop other processes was treated as a concept. Consideration was given to the impediments to development, the engineering process requirements and the governmental support for each process. The study describes the geothermal well site chosen, the pipeline to transmit the hydrothermal fluid, and the infrastructure required for the industrial park. A conceptual development plan for the ethanol plant, the feedmill and the papaya processing facility was prepared. The study concluded that a direct heat industrial park in Pahoa, Hawaii, involves considerable risks.« less

Production of anthocyanins in metabolically engineered microorganisms: Current status and perspectives.

PubMed

Zha, Jian; Koffas, Mattheos A G

2017-12-01

Microbial production of plant-derived natural products by engineered microorganisms has achieved great success thanks to large extend to metabolic engineering and synthetic biology. Anthocyanins, the water-soluble colored pigments found in terrestrial plants that are responsible for the red, blue and purple coloration of many flowers and fruits, are extensively used in food and cosmetics industry; however, their current supply heavily relies on complex extraction from plant-based materials. A promising alternative is their sustainable production in metabolically engineered microbes. Here, we review the recent progress on anthocyanin biosynthesis in engineered bacteria, with a special focus on the systematic engineering modifications such as selection and engineering of biosynthetic enzymes, engineering of transportation, regulation of UDP-glucose supply, as well as process optimization. These promising engineering strategies will facilitate successful microbial production of anthocyanins in industry in the near future.

Microengineering of Metals and Ceramics: Part II: Special Replication Techniques, Automation and Properties; Volume 4: Advanced Micro & Nanosystems

NASA Astrophysics Data System (ADS)

Baltes, Henry; Brand, Oliver; Fedder, Gary K.; Hierold, Christofer; Korvink, Jan G.; Tabata, Osamu; Löhe, Detlef; Haußelt, Jürgen

2005-10-01

Microstructures, electronics, nanotechnology - these vast fields of research are growing together as the size gap narrows and many different materials are combined. Current research, engineering sucesses and newly commercialized products hint at the immense innovative potentials and future applications that open up once mankind controls shape and function from the atomic level right up to the visible world without any gaps. Continuing from the previous volume, authors from three major competence centres for microengineering here cover all aspects of specialized replication techniques and how to employ state-of-the-art technologies for testing and characterizing micro-scale components, and illustrate quality control aspects and strategies for automation of production procedures in view of future industrial production and commercialisation.

Printing Technologies for Medical Applications.

PubMed

Shafiee, Ashkan; Atala, Anthony

2016-03-01

Over the past 15 years, printers have been increasingly utilized for biomedical applications in various areas of medicine and tissue engineering. This review discusses the current and future applications of 3D bioprinting. Several 3D printing tools with broad applications from surgical planning to 3D models are being created, such as liver replicas and intermediate splints. Numerous researchers are exploring this technique to pattern cells or fabricate several different tissues and organs, such as blood vessels or cardiac patches. Current investigations in bioprinting applications are yielding further advances. As one of the fastest areas of industry expansion, 3D additive manufacturing will change techniques across biomedical applications, from research and testing models to surgical planning, device manufacturing, and tissue or organ replacement. Copyright © 2016. Published by Elsevier Ltd.

Characterizing reliability in a product/process design-assurance program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerscher, W.J. III; Booker, J.M.; Bement, T.R.

1997-10-01

Over the years many advancing techniques in the area of reliability engineering have surfaced in the military sphere of influence, and one of these techniques is Reliability Growth Testing (RGT). Private industry has reviewed RGT as part of the solution to their reliability concerns, but many practical considerations have slowed its implementation. It`s objective is to demonstrate the reliability requirement of a new product with a specified confidence. This paper speaks directly to that objective but discusses a somewhat different approach to achieving it. Rather than conducting testing as a continuum and developing statistical confidence bands around the results, thismore » Bayesian updating approach starts with a reliability estimate characterized by large uncertainty and then proceeds to reduce the uncertainty by folding in fresh information in a Bayesian framework.« less

Patterning and templating for nanoelectronics.

PubMed

Galatsis, Kosmas; Wang, Kang L; Ozkan, Mihri; Ozkan, Cengiz S; Huang, Yu; Chang, Jane P; Monbouquette, Harold G; Chen, Yong; Nealey, Paul; Botros, Youssry

2010-02-09

The semiconductor industry will soon be launching 32 nm complementary metal oxide semiconductor (CMOS) technology node using 193 nm lithography patterning technology to fabricate microprocessors with more than 2 billion transistors. To ensure the survival of Moore's law, alternative patterning techniques that offer advantages beyond conventional top-down patterning are aggressively being explored. It is evident that most alternative patterning techniques may not offer compelling advantages to succeed conventional top-down lithography for silicon integrated circuits, but alternative approaches may well indeed offer functional advantages in realising next-generation information processing nanoarchitectures such as those based on cellular, bioinsipired, magnetic dot logic, and crossbar schemes. This paper highlights and evaluates some patterning methods from the Center on Functional Engineered Nano Architectonics in Los Angeles and discusses key benchmarking criteria with respect to CMOS scaling.

Role-play and the Industrial Revolution: an STS approach to the teaching of steam engines

NASA Astrophysics Data System (ADS)

Sabka, Diego; Pereira de Pereira, Alexsandro; Lima Junior, Paulo

2016-11-01

Role-play is an interesting, although underexplored, way of teaching physics in high school. This paper presents a science-technology-society (STS) approach to the teaching of heat engines based on a role-play of the Industrial Revolution. Enacting the role-play, students are presented not only to scientific concepts, but also to the social and technological controversies of industrial development.

Renovation of a mechanical engineering senior design class to an industry-tied and team-oriented course

NASA Astrophysics Data System (ADS)

Liu, Yucheng

2017-11-01

In this work, an industry-based and team-oriented education model was established based on a traditional mechanical engineering (ME) senior design class in order to better prepare future engineers and leaders so as to meet the increasing demand for high-quality engineering graduates. In the renovated curriculum, industry-sponsored projects became the most important course component and critical assessment tool, from which problem-solving skills as well as employability skills of the ME students can be fully developed. Hands-on experiences in finite element analysis (FEA) modelling and simulation were also added into the renovated curriculum to promote the application of FEA on engineering design and assessment. Evaluation of the renovated course was conducted using two instruments and the results have shown that the course made the ME senior students more prepared for their future career and a win-win model was created between the industry partner and the ME programme through it. Impact of the renovated syllabus on Accreditation Board for Engineering Technology goals was discussed. Based on the current progress, a more substantial change is being planned to further improve the effectiveness and practicability of this design course. The renovated course was started to offer to the ME senior students at Mississippi State University.

Harnessing the Environmental Professional Expertise of Engineering Students—The Course: ``Environmental Management Systems in the Industry''

NASA Astrophysics Data System (ADS)

Ben-Zvi-Assaraf, Orit; Ayal, Nitzan

2010-12-01

More and more technical universities now advocate integrating sustainability in higher education and including it as a strategic goal for improving education's quality and relevance to society. This study examines 30 fourth-year chemical engineering students, graduates of a university course designed to combine their terminological domain with sustainability-oriented goals, focusing on topics like corporate sustainability, developing environmental policy, introduction to ISO 14001—Environmental Management Systems (EMS), and environmental legislation. The study explores their perception of industrial-environmental issues and asks—How did the study unit influence the students' ability to use their preexisting scientific knowledge, while relating to industrial-environmental issues? Our findings indicate that engineering students can develop industrial-environmental awareness, and make use of interdisciplinary knowledge beyond that strictly related to the realm of engineering. Regarding the research's particular aim—i.e. determining the study unit's influence on students' ability to relate industrial-environmental issues to their own field of engineering—the findings indeed show a change in the students' conceptions of environmental elements related to industry. The course graduates became more attentive to the environmental aspects associated with building and opening a factory, and the concepts they raised in connection with the topic gained in variety.

Human Body Interfacing.

ERIC Educational Resources Information Center

Fryda, Lawrence J.; Harrington, Robert; Szumal, Clint

Electronics Engineering Technology majors in the Industrial and Engineering Technology department at Central Michigan University have developed many real-world projects that represent the type of problem-solving projects encouraged by industry. Two projects that can be used by other educators as freestanding projects or as the core for further…

Applications of aerospace technology in the electric power industry

NASA Technical Reports Server (NTRS)

Johnson, F. D.; Heins, C. F.

1974-01-01

Existing applications of NASA contributions to disciplines such as combustion engineering, mechanical engineering, materials science, quality assurance and computer control are outlined to illustrate how space technology is used in the electric power industry. Corporate strategies to acquire relevant space technology are described.

Bioethanol production from cellulosic hydrolysates by engineered industrial Saccharomyces cerevisiae.

PubMed

Lee, Ye-Gi; Jin, Yong-Su; Cha, Young-Lok; Seo, Jin-Ho

2017-03-01

Even though industrial yeast strains exhibit numerous advantageous traits for the production of bioethanol, their genetic manipulation has been limited. This study demonstrates that an industrial polyploidy Saccharomyces cerevisiae JHS200 can be engineered through Cas9 (CRISPR associated protein 9)-based genome editing. Specifically, we generated auxotrophic mutants and introduced a xylose metabolic pathway into the auxotrophic mutants. As expected, the engineered strain (JX123) enhanced ethanol production from cellulosic hydrolysates as compared to other engineered haploid strains. However, the JX123 strain produced substantial amounts of xylitol as a by-product during xylose fermentation. Hypothesizing that the xylitol accumulation might be caused by intracellular redox imbalance from cofactor difference, the NADH oxidase from Lactococcus lactis was introduced into the JX123 strain. The resulting strain (JX123_noxE) not only produced more ethanol, but also produced xylitol less than the JX123 strain. These results suggest that industrial polyploidy yeast can be modified for producing biofuels and chemicals. Copyright © 2016 Elsevier Ltd. All rights reserved.

Bridging the Gap: From 2D Cell Culture to 3D Microengineered Extracellular Matrices.

PubMed

Li, Yanfen; Kilian, Kristopher A

2015-12-30

Historically the culture of mammalian cells in the laboratory has been performed on planar substrates with media cocktails that are optimized to maintain phenotype. However, it is becoming increasingly clear that much of biology discerned from 2D studies does not translate well to the 3D microenvironment. Over the last several decades, 2D and 3D microengineering approaches have been developed that better recapitulate the complex architecture and properties of in vivo tissue. Inspired by the infrastructure of the microelectronics industry, lithographic patterning approaches have taken center stage because of the ease in which cell-sized features can be engineered on surfaces and within a broad range of biocompatible materials. Patterning and templating techniques enable precise control over extracellular matrix properties including: composition, mechanics, geometry, cell-cell contact, and diffusion. In this review article we explore how the field of engineered extracellular matrices has evolved with the development of new hydrogel chemistry and the maturation of micro- and nano- fabrication. Guided by the spatiotemporal regulation of cell state in developing tissues, techniques for micropatterning in 2D, pseudo-3D systems, and patterning within 3D hydrogels will be discussed in the context of translating the information gained from 2D systems to synthetic engineered 3D tissues. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Metabolic engineering of Yarrowia lipolytica for industrial applications.

PubMed

Zhu, Quinn; Jackson, Ethel N

2015-12-01

Yarrowia lipolytica is a safe and robust yeast that has a history of industrial applications. Its physiological, metabolic and genomic characteristics have made it a superior host for metabolic engineering. The results of optimizing internal pathways and introducing new pathways have demonstrated that Y. lipolytica can be a platform cell factory for cost-effective production of chemicals and fuels derived from fatty acids, lipids and acetyl-CoA. Two products have been commercialized from metabolically engineered Y. lipolytica strains producing high amounts of omega-3 eicosapentaenoic acid, and more products are on the way to be produced at industrial scale. Here we review recent progress in metabolic engineering of Y. lipolytica for production of biodiesel fuel, functional fatty acids and carotenoids. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Endovascular aortic repair: first twenty years.

PubMed

Koncar, Igor; Tolić, Momcilo; Ilić, Nikola; Cvetković, Slobodan; Dragas, Marko; Cinara, Ilijas; Kostić, Dusan; Davidović, Lazar

2012-01-01

Endovascular aortic/aneurysm repair (EVAR) was introduced into clinical practice at the beginning of the nineties. Its fast development had a great influence on clinicians, vascular surgeons and interventional radiologists, educational curriculums, patients, industry and medical insurance. The aim of this paper is to present the contribution of clinicians and industry to the development and advancement of endovascular aortic repair over the last 20 years. This review article presents the development of EVAR by focusing on the contribution of physicians, surgeons and interventional radiologists in the creation of the new field of vascular surgery termed hybrid vascular surgery, and also the contribution of technological advancement by a significant help of industrial representatives--engineers and their counselors. This article also analyzes studies conducted in order to compare the successfulness of EVAR with up-to-now applied open surgical repair of aortic aneurysms, and some treatment techniques of other aortic diseases. During the first two decades of its development the EVAR method was rapidly progressing and was adopted concurrently with the expansion of technology. Owing to large randomized studies, early and long-term results indicate specific complications of this method, thus influencing further technological improvement and defining risk patients groups in whom the use of the technique should be avoided. Good results are insured only in centers, specialized in vascular surgery, which have on their disposal adequate conditions for solving all complications associated with this method.

Two-Person Control: A Brief History and Modern Industry Practices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pedersen, Robert Douglas

Physical asset protection is the principal objective of many security and safeguard measures. One well-known means of asset protection is two-person control. This paper reviews literature regarding two-person control to gain insight into its origin, first demonstrated uses, and its presence in several modern industries. This literature review of two-person control is intended to benefit people and organizations with a desire to understand its origins and how the practice has evolved over time, as well as give some insight into the flexibility of this safeguarding technique. The literature review is focused in four main sections: (1) defining two-person control, (2)more » early history, (3) two-person control in modern industry, and (4) a theory on how two- person control entered modern industry. ACKNOWLEDGEMENTS The author would like to thank Jarret Lafleur and Scott Paap of Sandia National Laboratories, California's Systems Analysis & Engineering organization for the opportunity to work on this project. Jarret Lafleur provided very constructive and helpful feedback through all stages of the work. Amanda Thompson of the Sandia California Technical Library maintained a great spirit and always had a quick document turnaround that very much helped out this project's completion. Additionally, yet perhaps most importantly, the author would like to thank his wife and daughter, along with the rest of his family, for continued support over the years. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology and Engineering Solutions of Sandia, LLC., a wholly owned subsidiary of Honeywell International, Inc., for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525.« less