Science.gov

Sample records for industry blood establishment

  1. 78 FR 18353 - Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Blood Establishment Computer System... ``Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility'' dated April... establishment computer system validation program, consistent with recognized principles of software validation...

  2. 75 FR 75483 - Guidance for Industry: Recommendations for Blood Establishments: Training of Back-Up Personnel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ..., and Preservation of the Blood Supply in Response to Pandemic (H1N1) 2009 Virus'' dated November 2009... in Response to Pandemic (H1N1) 2009 Virus'' (November 2009). At that time, we anticipated that the rapid spread of pandemic (H1N1) 2009 virus had the potential to cause disruptions in the blood supply...

  3. Industry-Oriented Doctorate Established.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1982

    1982-01-01

    Describes an industry-related program at the University of Texas (Arlington) leading to a Doctorate of Science in Applied Chemistry. The program requires an industrial internship and a dissertation based on research involving both the university's chemistry faculty and chemists in industry. (SK)

  4. Industry-Oriented Doctorate Established.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1982

    1982-01-01

    Describes an industry-related program at the University of Texas (Arlington) leading to a Doctorate of Science in Applied Chemistry. The program requires an industrial internship and a dissertation based on research involving both the university's chemistry faculty and chemists in industry. (SK)

  5. Establishing Ergonomics in Industrially Developing Countries

    SciTech Connect

    Stewart, K; Silverstein, B; Kiefer, M

    2005-08-29

    The introduction of ergonomics is an ongoing effort in industrially developing countries and will ultimately require an organized, programmatic approach spanning several countries and organizations. Our preliminary efforts with our partner countries of Viet Nam, Thailand, and Nicaragua have demonstrated that a one-time course is just the first step in a series of necessary events to provide skills and create an infrastructure that will have lasting impact for the host country. To facilitate that any sort of training has a lasting impact, it is recommended that host countries establish a 'contract' with class participants and the guest instructors for at least one follow-up visit so instructors can see the progress and support the participants in current and future efforts. With repeated exchanges, the class participants can become the 'in country experts' and the next generation of ergonomic trainers. Additionally, providing participants with an easy to use hazard assessment tool and methods for evaluating the financial impact of the project (cost/benefit analysis) will assist increase the likelihood of success and establish a foundation for future projects. In the future, developing trade and regionally/culturally specific 'ergonomics toolkits' can help promote broader implementation, especially where training resources may be limited.

  6. Quality Assessment of Established and Emerging Blood Components for Transfusion

    PubMed Central

    Marks, Denese C.

    2016-01-01

    Blood is donated either as whole blood, with subsequent component processing, or through the use of apheresis devices that extract one or more components and return the rest of the donation to the donor. Blood component therapy supplanted whole blood transfusion in industrialized countries in the middle of the twentieth century and remains the standard of care for the majority of patients receiving a transfusion. Traditionally, blood has been processed into three main blood products: red blood cell concentrates; platelet concentrates; and transfusable plasma. Ensuring that these products are of high quality and that they deliver their intended benefits to patients throughout their shelf-life is a complex task. Further complexity has been added with the development of products stored under nonstandard conditions or subjected to additional manufacturing steps (e.g., cryopreserved platelets, irradiated red cells, and lyophilized plasma). Here we review established and emerging methodologies for assessing blood product quality and address controversies and uncertainties in this thriving and active field of investigation. PMID:28070448

  7. Quality Assessment of Established and Emerging Blood Components for Transfusion.

    PubMed

    Acker, Jason P; Marks, Denese C; Sheffield, William P

    2016-01-01

    Blood is donated either as whole blood, with subsequent component processing, or through the use of apheresis devices that extract one or more components and return the rest of the donation to the donor. Blood component therapy supplanted whole blood transfusion in industrialized countries in the middle of the twentieth century and remains the standard of care for the majority of patients receiving a transfusion. Traditionally, blood has been processed into three main blood products: red blood cell concentrates; platelet concentrates; and transfusable plasma. Ensuring that these products are of high quality and that they deliver their intended benefits to patients throughout their shelf-life is a complex task. Further complexity has been added with the development of products stored under nonstandard conditions or subjected to additional manufacturing steps (e.g., cryopreserved platelets, irradiated red cells, and lyophilized plasma). Here we review established and emerging methodologies for assessing blood product quality and address controversies and uncertainties in this thriving and active field of investigation.

  8. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Exemptions for blood product establishments. 607... BLOOD AND BLOOD PRODUCTS Exemptions § 607.65 Exemptions for blood product establishments. The following classes of persons are exempt from registration and blood product listing in accordance with this part...

  9. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Exemptions for blood product establishments. 607... BLOOD AND BLOOD PRODUCTS Exemptions § 607.65 Exemptions for blood product establishments. The following classes of persons are exempt from registration and blood product listing in accordance with this part...

  10. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Exemptions for blood product establishments. 607... BLOOD AND BLOOD PRODUCTS Exemptions § 607.65 Exemptions for blood product establishments. The following classes of persons are exempt from registration and blood product listing in accordance with this part...

  11. [Blood trace elements content in adolescents in an industrial town].

    PubMed

    Namazbaeva, Z I; Amanzhol, I A; Shibuchikova, Zh B; Sabirov, Zh B; Zhumabekova, S Zh

    2013-01-01

    A cohort blind study of blood trace elements content in children-adolescents aged 14-16 years old, residing in an industrial town, where large industrial enterprises of ferrous and non-ferrous metallurgy have been functioning for long periods, has been performed There was established a lack of vital important element selenium in the blood, that causes the accumulation of toxic metals, cadmium and mercury.

  12. Faculty's Role in Establishing Links with Industry.

    ERIC Educational Resources Information Center

    George, Yolanda S.

    1983-01-01

    Describes the Professional Development Program (PDP) at the University of California, Berkeley. This is a model faculty-industry effort which aims to increase enrollment and retain students in areas of science and technology. States that under this program, universities maintain excellence, and industry receives a better qualified work force. (NRJ)

  13. "Guidance for Industry: For the Submission of Chemistry, Manufacturing and Controls and Establishment Description Information for Human Blood and Blood Components Intended for Transfusion or for Further Manufacture and for the Completion of the Form FDA 356h, 'Application to Market a New Drug, Biologic or an Antibiotic Drug for Human Use;'" availability. Food and Drug Administration, HHS. Notice.

    PubMed

    1999-05-10

    The Food and Drug Administration (FDA) is announcing the availability of a document entitled "Guidance for Industry: For the Submission of Chemistry, Manufacturing and Controls and Establishment Description Information for Human Blood and Blood Components Intended for Transfusion or for Further Manufacture and For the Completion of the Form FDA 356h, 'Application to Market a New Drug, Biologic or an Antibiotic Drug for Human Use.'" This guidance document is intended to assist applicants in the preparation of the content and format of the chemistry, manufacturing, and controls (CMC) section and the establishment description section of a biologics license application (BLA), revised Form FDA 356h, for human blood and blood components intended for transfusion or for further manufacture. In addition, this guidance document provides assistance for the completion of the BLA. This action is part of FDA's continuing effort to achieve the objectives of the President's "Reinventing Government" initiatives and the Food and Drug Administration Modernization Act of 1997 (Modernization Act), to reduce unnecessary burdens for industry without diminishing public health protection.

  14. Industry supports establishing consortia on superconductivity

    SciTech Connect

    Not Available

    1989-08-01

    This article presents a summary of a survey conducted to determine if an initiative on the manufacture of high-temperature superconductor products holds any promise. The survey included questions on the planning of and participation in industrial consortia, government sponsorship of R and D directions for R and D manufacturing, and a plan for U.S. Department of Defense involvement in high-temperature superconductor consortia. The results of the survey, as well as the conclusions are discussed.

  15. 77 FR 59000 - Guidance for Industry: Pre-Storage Leukocyte Reduction of Whole Blood and Blood Components...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-25

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Pre-Storage Leukocyte Reduction of... availability of a document entitled ``Guidance for Industry: Pre- Storage Leukocyte Reduction of Whole Blood... blood establishments with recommendations for pre-storage leukocyte reduction of Whole Blood and...

  16. Blood pressure and industrial lead exposure.

    PubMed

    Maheswaran, R; Gill, J S; Beevers, D G

    1993-03-15

    The association between environmental lead exposure and raised blood pressure remains controversial. This association was examined in a cross-sectional study in 1981 on 809 male workers who were occupationally exposed to lead in a factory manufacturing car lead accumulator batteries in Birmingham, United Kingdom. Lead exposure was assessed by blood lead levels, blood zinc protoporphyrin levels, and years of industrial exposure to lead. The geometric mean blood lead level was 31.6 micrograms/dl with minimum and maximum values of 0 microgram/dl and 98 micrograms/dl, respectively. Unadjusted systolic blood pressure rose with increasing blood lead levels (analysis of variance, F = 3.3, p < 0.05) from 127 mmHg (95% confidence interval (CI) 123.5-130.5) in men with blood lead levels less than 21 micrograms/dl to 133 mmHg (95% CI 128.7-137.3) in men with levels exceeding 50 micrograms/dl. Following adjustment for the confounding effects of age, body mass index, and alcohol consumption, however, the effect of blood lead on systolic pressure was diminished (analysis of variance, F = 1.3, not significant) to 129 mmHg and 132 mmHg in the respective categories. There was no association between diastolic blood pressure and blood lead. Zinc protoporphyrin levels and years of industrial lead exposure did not raise adjusted systolic or diastolic pressure. In conclusion, subject to the limitations inherent in a cross-sectional survey, the findings are consistent with a weak effect of industrial lead exposure on systolic blood pressure, within the range of exposures observed in this study.

  17. 76 FR 5386 - Draft Guidance for Industry: Pre-Storage Leukocyte Reduction of Whole Blood and Blood Components...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Pre-Storage Leukocyte Reduction... availability of a draft document entitled ``Guidance for Industry: Pre- Storage Leukocyte Reduction of Whole... provides blood establishments with recommendations for pre- storage leukocyte reduction of Whole Blood...

  18. Injury underreporting among small establishments in the construction industry.

    PubMed

    Dong, Xiuwen S; Fujimoto, Alissa; Ringen, Knut; Stafford, Erich; Platner, James W; Gittleman, Janie L; Wang, Xuanwen

    2011-05-01

    There is convincing evidence that occupational injury and illness rates, particularly those reported by employers in the BLS' Survey of Occupational Injuries and Illnesses (SOII), substantially underestimate the true magnitude of injury and illness in the construction industry. Fifteen years of data from five large nationally representative data sources were analyzed, including SOII, CFOI, CBP, CPS, and MEPS. Regression trends and ratio analyses were conducted, and stratified by establishment size and Hispanic ethnicity. Small construction establishments were most likely to underreport injuries. The SOII data only captured 25% of severe injuries among Hispanic workers, and 60% among white workers in small construction establishments. Underreporting is pervasive in the construction industry for small establishments and Hispanic workers. Given that small establishments are predominant in the U.S. construction industry, they should be the focus of a larger effort to identify the true extent of construction-related injuries. Copyright © 2011 Wiley-Liss, Inc.

  19. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for...

  20. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for...

  1. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for...

  2. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for...

  3. Establishment and development of irradiation technology industry in Shenzhen

    NASA Astrophysics Data System (ADS)

    Shou-yi, Lu

    1993-07-01

    This paper discusses the establishment and development of radiation processing—the new technology industry in Shenzhen special economic zone, China, from importing a complete set of irradiation equipment to establishing an industrial system of irradiation commercialization. Through the organization of irradiation production, the safety operation of the equipment, the development of irradiation products, the pioneering of technical markets, the increase of economic benefit and the reveal of social benefit, the irradiation technology industry in Shenzhen has formed a productive capacity of 1 million curies of Cobalt-60 just in a few years. This shows a bright future of the new technical industry. This paper also points out that the radiation sterilization is a ripe and practical technology in the present irradiation technology industry. The academic circles and industrial circles in the world now should closely cooperate to make the superior sterilization technology convinced by the public. The appropriate administrative measures should be taken to make it extended and popularized. This not only increases the level of social medical health, but also urges the irradiation technology to have an outstanding development in commercialization.

  4. Establishing Chlamydomonas reinhardtii as an industrial biotechnology host

    PubMed Central

    Scaife, Mark A; Nguyen, Ginnie TDT; Rico, Juan; Lambert, Devinn; Helliwell, Katherine E; Smith, Alison G

    2015-01-01

    Microalgae constitute a diverse group of eukaryotic unicellular organisms that are of interest for pure and applied research. Owing to their natural synthesis of value-added natural products microalgae are emerging as a source of sustainable chemical compounds, proteins and metabolites, including but not limited to those that could replace compounds currently made from fossil fuels. For the model microalga, Chlamydomonas reinhardtii, this has prompted a period of rapid development so that this organism is poised for exploitation as an industrial biotechnology platform. The question now is how best to achieve this? Highly advanced industrial biotechnology systems using bacteria and yeasts were established in a classical metabolic engineering manner over several decades. However, the advent of advanced molecular tools and the rise of synthetic biology provide an opportunity to expedite the development of C. reinhardtii as an industrial biotechnology platform, avoiding the process of incremental improvement. In this review we describe the current status of genetic manipulation of C. reinhardtii for metabolic engineering. We then introduce several concepts that underpin synthetic biology, and show how generic parts are identified and used in a standard manner to achieve predictable outputs. Based on this we suggest that the development of C. reinhardtii as an industrial biotechnology platform can be achieved more efficiently through adoption of a synthetic biology approach. Significance Statement Chlamydomonas reinhardtii offers potential as a host for the production of high value compounds for industrial biotechnology. Synthetic biology provides a mechanism to generate generic, well characterised tools for application in the rational genetic manipulation of organisms: if synthetic biology principles were adopted for manipulation of C. reinhardtii, development of this microalga as an industrial biotechnology platform would be expedited. PMID:25641561

  5. Establishing Chlamydomonas reinhardtii as an industrial biotechnology host.

    PubMed

    Scaife, Mark A; Nguyen, Ginnie T D T; Rico, Juan; Lambert, Devinn; Helliwell, Katherine E; Smith, Alison G

    2015-05-01

    Microalgae constitute a diverse group of eukaryotic unicellular organisms that are of interest for pure and applied research. Owing to their natural synthesis of value-added natural products microalgae are emerging as a source of sustainable chemical compounds, proteins and metabolites, including but not limited to those that could replace compounds currently made from fossil fuels. For the model microalga, Chlamydomonas reinhardtii, this has prompted a period of rapid development so that this organism is poised for exploitation as an industrial biotechnology platform. The question now is how best to achieve this? Highly advanced industrial biotechnology systems using bacteria and yeasts were established in a classical metabolic engineering manner over several decades. However, the advent of advanced molecular tools and the rise of synthetic biology provide an opportunity to expedite the development of C. reinhardtii as an industrial biotechnology platform, avoiding the process of incremental improvement. In this review we describe the current status of genetic manipulation of C. reinhardtii for metabolic engineering. We then introduce several concepts that underpin synthetic biology, and show how generic parts are identified and used in a standard manner to achieve predictable outputs. Based on this we suggest that the development of C. reinhardtii as an industrial biotechnology platform can be achieved more efficiently through adoption of a synthetic biology approach. © 2015 The Authors The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.

  6. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  7. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  8. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  9. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  10. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  11. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Inspection of establishment registrations and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  12. Sanitizing Rhetorics of the Commercial Blood Plasma Industry.

    ERIC Educational Resources Information Center

    Anderson, Leon; Moser, Christina

    The United States blood plasma industry uses various rhetorics to access donors and markets its products while managing its stigma and potential legal liability. The industry includes both the public "nonprofit" sector and the private, for-profit blood collection and manufacturing businesses owned by pharmaceutical companies that rely on…

  13. 76 FR 42715 - Quarantine Release Errors in Blood Establishments; Public Workshop

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... HUMAN SERVICES Food and Drug Administration Quarantine Release Errors in Blood Establishments; Public... Administration (FDA) is announcing a public workshop entitled: ``Quarantine Release Errors in Blood... workshop will focus on the extent and characteristics of QREs in blood establishments and...

  14. Ovine blood: establishment of a list of reference values relevant for blood coagulation in sheep.

    PubMed

    Wilhelmi, Mathias H; Tiede, Andreas; Teebken, Omke E; Bisdas, Theodosios; Haverich, Axel; Mischke, Reinhard

    2012-01-01

    Ovine animal models are widely used to conduct preclinical studies, e.g., to evaluate cardiovascular prostheses intended to be applied in man. However, although analyzed in many of those studies, information about ovine blood reference values is scanty. The aim of this study is to establish a reference list of ovine blood parameters relevant for blood coagulation. A cohort of 47 mature ewes was evaluated. Parameters comprised the following: cells and cellular components-platelet, red, and white cell counts (including subsets), hemoglobin (Hb), hematocrit (HCT), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV), and MCH concentration (MCHC); global tests of coagulation-prothrombin time (Quick's time) and activated partial thromboplastin time (aPTT); and parameters relevant for blood coagulation-fibrinogen, antithrombin (AT), and von Willebrand Factor. After explorative data analysis, a list of ovine reference values was established. Interestingly, a comparison with human reference values revealed some interspecies differences between sheep and man, i.e., much higher ovine ranges for some cell counts (neutrophils, lymphocytes, basophils, eosinophils, and platelets) but lower values for some other parameters (Hb, HCT, MCV, MCH, AT, and Quick's test). We established a reference list of ovine blood count and blood coagulation parameters. Because of some peculiarities of the ovine blood, this list may have implications for the interpretation of experimental data.

  15. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  16. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  17. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  18. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  19. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  20. From research to industry — The establishment of a radiation processing industry in South Africa

    NASA Astrophysics Data System (ADS)

    Plessis, T. A. Du; Stevens, RCB

    In the late sixties the South African Atomic Energy Board in pursuing its objectives to promote the peaceful application of nuclear energy in general, established a research group with the specific purpose of investigating and developing radiation processing as a new technique. During the early years it was realised that the economic and technological facets of establishing a new industry were equally important and, in addition to fundamental research, strong emphasis was placed on the necessity of marketing this new technology. Although the initial emphasis was put on gamma sterilization, and today still forms the backbone of the radiation processing industry, the promising fields of polymer modification and food irradiation hold a lot of promise in the radiation processing industry. Following ten years of successfully introducing and providing a radiation service, the South African Atomic Energy Board in 1980 decided to transfer its service to the private sector. These developments in South Africa are a good sample of how a small country, through initial government envolvement, can acquire a sophisticated new private industry.

  1. Establishing space industry in developing countries: Opportunities and difficulties

    NASA Astrophysics Data System (ADS)

    Leloglu, U. M.; Kocaoglan, E.

    2008-12-01

    Although it is generally agreed that the outer space should be used for the benefit of all mankind, only a fraction of the countries have the necessary technological base for accessing space. Space technology, with its implications on science, economy and well-being of citizens, is mostly chosen as one of the priority areas for technological development by developing countries. However, there is already an over-capacity in global space industry and there are doubts on necessity of additional capacity establishment by developing countries. In this study, the importance and benefits of capacity-building in these countries are emphasized and the advantages and disadvantages that developing countries have in the framework of space technology acquisition are briefly presented. The feasibility of certain levels of space technology is discussed and the necessity of combining existing indigenous capabilities with technology obtained from foreign sources in the optimal way is stressed. We have also mentioned various general mechanisms of technology transfer and argued the importance of licensing in catching-up developed countries. After considering the necessary conditions of efficiency of technology, such as establishment of regional centers of space science and technology education by United Nations, joint development of space systems, complete technology transfer packages, cooperative space projects within regional organizations, coordinated constellations and special agreements with large space agencies, which are specific mechanisms already in use, are reviewed. Some typical examples of mechanisms are also given with special emphasize on small satellite technology that makes access to space affordable for many countries. Through sharing and analyzing the experience of developing countries in their odyssey of space capacity-building, the difficulties can be negotiated and the vicious circles can be broken. This study, in our view, is a step to incite a general

  2. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Partial exemption for establishments in certain industries... Partial exemption for establishments in certain industries. (a) Basic requirement. (1) If your business establishment is classified in a specific low hazard retail, service, finance, insurance or real estate industry...

  3. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a)...

  4. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  5. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  6. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  7. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a)...

  8. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  9. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a)...

  10. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a)...

  11. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  12. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... blood product listings. 607.37 Section 607.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  13. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... blood product listings. 607.37 Section 607.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  14. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... blood product listings. 607.37 Section 607.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  15. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... blood product listings. 607.37 Section 607.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  16. Industrial bioprocesses: beyond routine applications of established methodologies.

    PubMed

    Junker, Beth

    2010-04-15

    The subject matter of manuscripts by industrial authors has primarily focused on elements with perceived commercial or regulatory significance. Once published, this information interacted and ultimately influenced manuscripts from authors of other affiliations, creating the rapid advancements that culminated in the current multi-billion dollar worldwide biotechnology industry. This paper discusses trends in "solely industrial" articles published in the specific journal of Biotechnology and Bioengineering over the past five decades of this journal's lifetime. "Solely industrial" articles were defined as papers in which all the authors were affiliated with industry. Data were gathered concerning "solely industrial" article distribution and frequency, authoring companies, subject classification, and category distribution. Selected articles and their impact were related to current and past technology milestones as well as associated challenges. Suggestions for areas of greater emphasis to influence the number and subject matter of "solely industrial" articles for the journal's sixth decade were offered for consideration.

  17. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... establishment is classified in a specific low hazard retail, service, finance, insurance or real estate industry..., insurance or real estate industries (SICs 52-89)? Yes, business establishments classified in agriculture... 29 Labor 5 2012-07-01 2012-07-01 false Partial exemption for establishments in certain...

  18. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... establishment is classified in a specific low hazard retail, service, finance, insurance or real estate industry..., insurance or real estate industries (SICs 52-89)? Yes, business establishments classified in agriculture... 29 Labor 5 2011-07-01 2011-07-01 false Partial exemption for establishments in certain...

  19. [How do I assess requirement of a blood bank and its kind for a healthcare establishment?].

    PubMed

    Lafeuillade, B; Tixier, A; Bliem, C; Meyer, F

    2014-12-01

    Access to blood components is required for healthcare establishments, particularly for emergency situation and hospital blood bank was often a response to this requirement. However, the complexity of regulation and economic pressures lead healthcare establishment to review regularly their need for a blood bank. This assessment requires analysis of need for transfusions in terms of delay, quantity and clinical situations to which they must respond. When a blood bank is required, three kinds could be under consideration: emergency blood bank, intermediate blood bank and issuance blood bank. According to requirements, advantages and disadvantages of each kind, healthcare establishments would select the most suitable one.

  20. Cord blood stem cell transplantation. Why it is necessary to establish a Bulgarian cord blood bank?

    PubMed

    Zlatev, Asen; Mihaylova, Anastasia; Baltadjieva, Daniela; Ivanova, Milena; Naumova, Elissaveta

    2008-12-01

    The allogenic transplantation of hemopoietic stem cell from bone marrow and peripheral blood is limited due to the necessity to identify HLA matched donor within the family or in bone marrow donor registries. Although, more than 10 million donors are available worldwide, completely HLA matched donors could be found only for 75% of the patients. It is well known that transplantations of hematopoietic stem cell from cord blood are characterized with a lower risk of GvHD and therefore do not require so strict criteria for HLA matching, and less time for search of matched donor is needed. The necessity to establish a National cord blood bank in Bulgaria is emphasized further by the heterogeneity of HLA allele and haplotype distribution in the Bulgarian population. That could be explained by the ethnic diversity of the population. As a result some alleles are more frequent in Bulgarians compared to other populations. The organization, accreditation, and development of a strategy for a National cord blood bank will be discussed.

  1. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Pharmacies that are operating under applicable local laws regulating dispensing of prescription drugs and... the profession of pharmacy including the business of dispensing and selling blood products at retail. The supplying by such pharmacies of blood products to a practitioner licensed to administer such...

  2. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... for use in research, teaching, or analysis, including laboratory samples. (d) Carriers, by reason of... use, or preparation of red blood cells for transfusion are not acts requiring such transfusion...

  3. Establishing the diffuse correlation spectroscopy signal relationship with blood flow.

    PubMed

    Boas, David A; Sakadžić, Sava; Selb, Juliette; Farzam, Parisa; Franceschini, Maria Angela; Carp, Stefan A

    2016-07-01

    Diffuse correlation spectroscopy (DCS) measurements of blood flow rely on the sensitivity of the temporal autocorrelation function of diffusively scattered light to red blood cell (RBC) mean square displacement (MSD). For RBCs flowing with convective velocity [Formula: see text], the autocorrelation is expected to decay exponentially with [Formula: see text], where [Formula: see text] is the delay time. RBCs also experience shear-induced diffusion with a diffusion coefficient [Formula: see text] and an MSD of [Formula: see text]. Surprisingly, experimental data primarily reflect diffusive behavior. To provide quantitative estimates of the relative contributions of convective and diffusive movements, we performed Monte Carlo simulations of light scattering through tissue of varying vessel densities. We assumed laminar vessel flow profiles and accounted for shear-induced diffusion effects. In agreement with experimental data, we found that diffusive motion dominates the correlation decay for typical DCS measurement parameters. Furthermore, our model offers a quantitative relationship between the RBC diffusion coefficient and absolute tissue blood flow. We thus offer, for the first time, theoretical support for the empirically accepted ability of the DCS blood flow index ([Formula: see text]) to quantify tissue perfusion. We find [Formula: see text] to be linearly proportional to blood flow, but with a proportionality modulated by the hemoglobin concentration and the average blood vessel diameter.

  4. Family planning programs in industrial establishments: an operations research study.

    PubMed

    Cabigon, J; Magsino, E

    1993-01-01

    An operations research study in the Philippines sought to uncover determinants of the sustainability of employment-based family planning (FP) programs offered in industrial settings where the Philippine Center for Population and Development (PCPD) had provided assistance in implementing Responsible Parenthood/FP-Maternal Health (RP/FP-MH) Programs. Qualitative data were gathered through observations and interviews with the target population and with company management and program implementers. Based on this study, the following recommendations were made: 1) training outputs should be echoed to employees immediately; 2) RP/FP-MCH team members should be recruited from each level of the work force; 3) an appropriate IEC (information, education, and communication) strategy should be devised to respond to the short time-frame in which employees can participate; 4) team-building training should be incorporated as a regular activity early in the contract period; 5) sectoral targeting should be used within a given company; 6) training programs should be designed for each of the three types of team members and should overlap the basic topics; 7) teamwork and mutual assistance should be encouraged; 8) the work of the teams should be rewarded; 9) commendable initiative of liaison officers should be sustained; 10) representatives of the PCPD should maintain a close relationship with the teams through PCPD staff visits to the companies; 11) management requires more intensive orientation on the RP/FP-MH program; 12) PCPD support should be withdrawn gradually until the companies are able to sustain the program themselves; 13) it may be helpful to require a company to meet rigid criteria in order to take part in the PCPD project; 14) OR should be continued; and 15) the concept and practice of quality of care should be introduced to service delivery and training of staff and motivators.

  5. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Blood meal, blood albumin, intestines... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use; importations permitted subject to restrictions. Blood meal, blood albumin, bone meal, intestines, or other animal...

  6. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Blood meal, blood albumin, intestines... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use; importations permitted subject to restrictions. Blood meal, blood albumin, bone meal, intestines, or other animal...

  7. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Blood meal, blood albumin, intestines... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use; importations permitted subject to restrictions. Blood meal, blood albumin, bone meal, intestines, or other animal...

  8. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Blood meal, blood albumin, intestines... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use; importations permitted subject to restrictions. Blood meal, blood albumin, bone meal, intestines, or other animal...

  9. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Blood meal, blood albumin, intestines... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use; importations permitted subject to restrictions. Blood meal, blood albumin, bone meal, intestines, or other animal...

  10. Establishment and Dysfunction of the Blood-Brain Barrier

    PubMed Central

    Zhao, Zhen; Nelson, Amy R.; Betsholtz, Christer; Zlokovic, Berislav V.

    2015-01-01

    Structural and functional brain connectivity, synaptic activity and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases including Alzheimer’s disease. PMID:26590417

  11. The value to blood establishments of supplier quality audit and of adopting a European Blood Alliance collaborative approach.

    PubMed

    Nightingale, Mark J; Ceulemans, Jan; Agoston, Stephanie; van Mourik, Peter; Marcou-Cherdel, Céline; Wickens, Betty; Johnstone, Pauline

    2014-01-01

    The assessment of suppliers of critical goods and services to European blood establishments is a regulatory requirement proving difficult to resource. This study was to establish whether European Blood Alliance member blood services could collaborate to reduce the cost of auditing suppliers without diminishing standards. Five blood services took part, each contributing a maximum of one qualified auditor per audit (rather than the usual two). Four audits were completed involving eight auditors in total to a European Blood Alliance agreed policy and process using an audit scope agreed with suppliers. Audits produced a total of 22 observations, the majority relating to good manufacturing practice and highlighted deficiencies in processes, procedures and quality records including complaints' handling, product recall, equipment calibration, management of change, facilities' maintenance and monitoring and business continuity. Auditors reported that audits had been useful to their service and all audits prompted a positive response from suppliers with satisfactory corrective action plans where applicable. Audit costs totalled € 3,438 (average € 860 per audit) which is no more than equivalent traditional audits. The four audit reports have been shared amongst the five participating blood establishments and benefitted 13 recipient departments in total. Previously, 13 separate audits would have been required by the five blood services. Collaborative supplier audit has proven an effective and efficient initiative that can reduce the resource requirements of both suppliers and individual blood service's auditing costs. Collaborative supplier audit has since been established within routine European Blood Alliance management practice.

  12. 7 CFR 1260.113 - Established national nonprofit industry-governed organizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Definitions § 1260.113 Established... directors representing the cattle or beef industry on a national basis; and (c) Were active and...

  13. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use in...

  14. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use in...

  15. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use in...

  16. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use in...

  17. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use in...

  18. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  19. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  20. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  1. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  2. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  3. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Classification code for my company or for individual establishments? You determine your Standard Industrial.... 1904.2 Section 1904.2 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... employees (see § 1904.39). (2) If one or more of your company's establishments are classified in a non...

  4. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Classification code for my company or for individual establishments? You determine your Standard Industrial.... 1904.2 Section 1904.2 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... employees (see § 1904.39). (2) If one or more of your company's establishments are classified in a non...

  5. 78 FR 13069 - Draft Guidance for Industry: Recommendations for Screening, Testing, and, Management of Blood...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ...: Recommendations for Screening, Testing, and, Management of Blood Donors and Blood and Blood Components Based on... entitled ``Guidance for Industry: Recommendations for Screening, Testing, and Management of Blood Donors and Blood and Blood Components Based on Screening Tests for Syphilis,'' dated March 2013. The...

  6. The value to blood establishments of supplier quality audit and of adopting a European Blood Alliance collaborative approach

    PubMed Central

    Nightingale, Mark J.; Ceulemans, Jan; Ágoston, Stephanie; van Mourik, Peter; Marcou-Cherdel, Céline; Wickens, Betty; Johnstone, Pauline

    2014-01-01

    Background The assessment of suppliers of critical goods and services to European blood establishments is a regulatory requirement proving difficult to resource. This study was to establish whether European Blood Alliance member blood services could collaborate to reduce the cost of auditing suppliers without diminishing standards. Materials and method Five blood services took part, each contributing a maximum of one qualified auditor per audit (rather than the usual two). Four audits were completed involving eight auditors in total to a European Blood Alliance agreed policy and process using an audit scope agreed with suppliers. Results Audits produced a total of 22 observations, the majority relating to good manufacturing practice and highlighted deficiencies in processes, procedures and quality records including complaints’ handling, product recall, equipment calibration, management of change, facilities’ maintenance and monitoring and business continuity. Auditors reported that audits had been useful to their service and all audits prompted a positive response from suppliers with satisfactory corrective action plans where applicable. Audit costs totalled € 3,438 (average € 860 per audit) which is no more than equivalent traditional audits. The four audit reports have been shared amongst the five participating blood establishments and benefitted 13 recipient departments in total. Previously, 13 separate audits would have been required by the five blood services. Discussion Collaborative supplier audit has proven an effective and efficient initiative that can reduce the resource requirements of both suppliers and individual blood service’s auditing costs. Collaborative supplier audit has since been established within routine European Blood Alliance management practice. PMID:24553596

  7. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Notification of registrant; blood product... PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.35 Notification of registrant; blood product establishment registration number and...

  8. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Notification of registrant; blood product... PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.35 Notification of registrant; blood product establishment registration number and...

  9. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Notification of registrant; blood product... PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.35 Notification of registrant; blood product establishment registration number and...

  10. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Notification of registrant; blood product... PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.35 Notification of registrant; blood product establishment registration number and...

  11. Establishment of a Graduate Certificate Program in Biobased Industrial Products – Final Technical Report

    SciTech Connect

    John R. Schlup

    2005-11-04

    A certificate of graduate studies in Biobased Industrial Products is to be established at Kansas State University (KSU) along with the development of a similar program at Pittsburg State University, Pittsburg, KS. At KSU, the program of study will be coordinated through the steering committee of the Agricultural Products Utilization Forum (APUF); the certificate of graduate studies will be awarded through the Graduate School of Kansas State University. This certificate will establish an interdisciplinary program of study that will: (1) ensure participating students receive a broad education in several disciplines related to Biobased Industrial Products, (2) provide a documented course of study for students preferring a freestanding certificate program, and (3) provide a paradigm shift in student awareness away from petroleum-based feedstocks to the utilization of renewable resources for fuels and chemical feedstocks. The academic program described herein will accomplish this goal by: (1) providing exposure to several academic disciplines key to Biobased Industrial Products; (2) improving university/industry collaboration through an external advisory board, distance learning opportunities, and student internships; (3) expanding the disciplines represented on the students' supervisory committee; (4) establishing a seminar series on Biobased Industrial Products that draws upon expert speakers representing several disciplines; and (5) increasing collaboration between disciplines. Numerous research programs emphasizing Biobased Industrial Products currently exist at KSU and PSU. The certificate of graduate studies, the emphasis on interdisciplinary collaboration within the students? thesis research, the proposed seminar series, and formation of an industrial advisory board will: (1) provide an interdisciplinary academic experience that spans several departments, four colleges, four research centers, and two universities; (2) tangibly promote collaboration between KSU

  12. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Information required for establishment registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... product substances as well as finished dosage forms, by established name as defined in section 502(e)...

  13. [Analysis on establishment and affecting factors of qi stagnation and blood stasis rat model].

    PubMed

    Wang, Tingting; Jia, Cheng; Chen, Yu; Li, Xin; Cheng, Jiayi

    2012-06-01

    To study on the method for establishing the Qi stagnation and blood stasis rat model and analyze the affecting factors. The orthogonal design was adopted to study the influences of joint stimulations including noise, light, electricity, ice water bath, tail-clamping on model rats. The 'flying spot' method was used to dynamically simulate blood flow velocity in microcirculation. the pressure sensing technology of MOTO was adopted to detect hemorheology-related indicators. And the coagulation method was used to detect blood coagulation-related indicators. Compared with the negative control group, all model groups showed significant reduction in the blood flow velocity in mesenteric microcirculation and increase in the whole blood viscosity at high, medium and low shear rate, the plasma viscosity and the fibrinogen content in four blood coagulation indicators. Noise, light, electricity, tail-clamping, bondage and icewater-bath make significant impact on model rats.

  14. Quality management in European screening laboratories in blood establishments: A view of current approaches and trends.

    PubMed

    Pereira, Paulo; Westgard, James O; Encarnação, Pedro; Seghatchian, Jerard; de Sousa, Gracinda

    2015-04-01

    The screening laboratory has a critical role in the post-transfusion safety. The success of its targets and efficiency depends on the management system used. Even though the European Union directive 2002/98/EC requires a quality management system in blood establishments, its requirements for screening laboratories are generic. Complementary approaches are needed to implement a quality management system focused on screening laboratories. This article briefly discusses the current good manufacturing practices and good laboratory practices, as well as the trends in quality management system standards. ISO 9001 is widely accepted in some European Union blood establishments as the quality management standard, however this is not synonymous of its successful application. The ISO "risk-based thinking" is interrelated with the quality risk-management process of the EuBIS "Standards and criteria for the inspection of blood establishments". ISO 15189 should be the next step on the quality assurance of a screening laboratory, since it is focused on medical laboratory. To standardize the quality management systems in blood establishments' screening laboratories, new national and European claims focused on technical requirements following ISO 15189 is needed.

  15. [Establishment of Method for Detecting Red Blood Cell Osmotic Fragility by Flow Cytometry].

    PubMed

    Zhu, Hong-Yan; Meng, Qiang; Ouyan, Hong-Mei; Dong, Ting; Zhang, Qiong-Yue; Zhou, You-Quan; Ping, Zhu-Xian

    2016-02-01

    To establish a new method for detection of red blood cell osmotic fragility by using flow cytometry. The hypotension salt solution of different concentrations (0.70 ml normal saline+0.3 ml deionized water, 0.60 ml normal saline+0.40 ml deionized water and 0.55 ml normal saline+0.45 ml deionized water) were prepared with normal saline and deionized water, in which the red blood cells were suspended, and the residual red blood cells were detected by flow cytometer. There was no significant difference in percentage of residual red blood cells between different time points detected by flow cytometer in 3 different hypotonic salt solutions. The percentage of residual red blood cells in B+C+D+E+F+G detected time region was different among 3 NaCl dilution groups. The percentage of residual red blood cells in normal control was lower than that in hemoglobinopathy group. The percentage of residual red blood cells in hereditary spherocytosis (HS) group was obviously lower than that in hemoglobinopathy and normal control groups. The comparison of 3 different dilution concentrations found that the second concentration (0.60 ml normal saline+0.40 ml deionized water) is more suitable to screen HS by FC500 flow cytometer. The detection of red cell osmotic fragility by using flow cytometry is a simple, rapid, objective and economic way that can be an effective screening method for diagnose the HS.

  16. First optical education center in Japan established by cooperation between academia and industry

    NASA Astrophysics Data System (ADS)

    Yatagai, Toyohiko

    2014-07-01

    At the present of the 21st century, optical technology became what must be in our life. If there is no optical technology, we cannot use optical equipments such as the camera, microscopes, DVD, LEDs and laser diodes (LDs). Optics is also the leading part in the most advanced scientific field. It is clear that the organization which does education and research is required in such a very important area. Unfortunately, there was no such organization in Japan. The education and research of light have been individually done in various faculties of universities, various research institutes, and many companies. However, our country is now placed in severer surroundings, such as the globalization of our living, the accelerated competition in research and development. This is one of the reasons why Utsunomiya University has established Center for Optical Research and Education (CORE) in 2007. To contribute to optical technology and further development of optical industry, "Center for Optical Research and Education (CORE), Utsunomiya University" promotes education and research in the field of the optical science and technology cooperatively with industry, academia and the government. Currently, 6 full professors, 21 cooperative professors, 2 visiting professors and 7 post-doctoral researchers and about 40 students are joined with CORE. Many research projects with industries, the local government of Tochigi as well as Japanese government. Optical Innovation Center has established in CORE by supporting of Japan Science and Technology Agency in 2011 to develop advanced optical technologies for local companies.

  17. 71 FR 36519 - Announcement of a Meeting To Explore Feasibility of Establishing a NIST/Industry Consortium on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2006-06-27

    ... Establishing a NIST/Industry Consortium on Metrological Aspects of X-Ray Diffraction and X-Ray Reflectometry... evaluate industry interest in a NIST/Industry Consortium on metrological aspects of X-Ray ] Diffraction and... pre-consortium meeting to be held on August 10, 2006 in conjunction with the 55th Annual Denver X-......

  18. Court upholds $405,000 award against blood banking industry.

    PubMed

    1995-06-30

    The New Jersey Superior Court has ruled that the American Association of Blood Banks (AABB), the nation's largest blood bank trade group, was negligent during the early 1980s when it recommended that blood banks not screen and test donors to reduce the chance of HIV contamination of the nation's blood supply. [Name removed], who received HIV-contaminated blood in 1984 as a result of a transfusion at St. Joseph's Hospital in Paterson, sued and reached out-of-court settlements with his doctors and the Bergen Community Blood Center, which provided the blood. Only the AABB suit proceeded to trial, with the jury finding that one-third of the damages were attributable to the AABB's actions. In 1983, the Centers for Disease Control and Prevention (CDC) suggested that blood banks might reduce the risk of AIDS entering the blood supply by using the surrogate hepatitis B test. The AABB, the American Red Cross, and the Council of Community Blood Centers recommended against testing, saying that evidence of transmission by blood was inconclusive and unproven. In March 1985, the AABB adopted the ELISA test. This is the first time the AABB has been held responsible; the AABB said it may appeal the decision. The court disagreed with AABB's claim that it was immune from liability because it was a charity, saying it also performs a critical governance function in respect of the operation of blood banks. The decision puts considerable liability for the U.S. cases of HIV contracted through tainted blood transfusions on the AABB.

  19. Establishing traceability of photometric absorbance values for accurate measurements of the haemoglobin concentration in blood

    NASA Astrophysics Data System (ADS)

    Witt, K.; Wolf, H. U.; Heuck, C.; Kammel, M.; Kummrow, A.; Neukammer, J.

    2013-10-01

    Haemoglobin concentration in blood is one of the most frequently measured analytes in laboratory medicine. Reference and routine methods for the determination of the haemoglobin concentration in blood are based on the conversion of haeme, haemoglobin and haemiglobin species into uniform end products. The total haemoglobin concentration in blood is measured using the absorbance of the reaction products. Traceable absorbance measurement values on the highest metrological level are a prerequisite for the calibration and evaluation of procedures with respect to their suitability for routine measurements and their potential as reference measurement procedures. For this purpose, we describe a procedure to establish traceability of spectral absorbance measurements for the haemiglobincyanide (HiCN) method and for the alkaline haematin detergent (AHD) method. The latter is characterized by a higher stability of the reaction product. In addition, the toxic hazard of cyanide, which binds to the iron ion of the haem group and thus inhibits the oxygen transport, is avoided. Traceability is established at different wavelengths by applying total least-squares analysis to derive the conventional quantity values for the absorbance from the measured values. Extrapolation and interpolation are applied to get access to the spectral regions required to characterize the Q-absorption bands of the HiCN and AHD methods, respectively. For absorbance values between 0.3 and 1.8, the contributions of absorbance measurements to the total expanded uncertainties (95% level of confidence) of absorbance measurements range from 1% to 0.4%.

  20. Prospects for Establishment of Technological Complexes in Machine Building Industry on The Basis of Electromechatronic Propulsion Systems

    NASA Astrophysics Data System (ADS)

    Osipov, Yu M.; Osipov, O. Yu; Trifonov, V. A.

    2015-09-01

    The authors consider prospects for technological complex establishment in machine building industry on the basis of electromechatronic propulsion systems for production of innovative products with different novelty levels: world, state, brunch, region, etc.

  1. Methods for establishing a surveillance system for cardiovascular diseases in Indian industrial populations.

    PubMed Central

    Reddy, K. S.; Prabhakaran, D.; Chaturvedi, V.; Jeemon, P.; Thankappan, K. R.; Ramakrishnan, L.; Mohan, B. V. M.; Pandav, C. S.; Ahmed, F. U.; Joshi, P. P.; Meera, R.; Amin, R. B.; Ahuja, R. C.; Das, M. S.; Jaison, T. M.

    2006-01-01

    OBJECTIVE: To establish a surveillance network for cardiovascular diseases (CVD) risk factors in industrial settings and estimate the risk factor burden using standardized tools. METHODS: We conducted a baseline cross-sectional survey (as part of a CVD surveillance programme) of industrial populations from 10 companies across India, situated in close proximity to medical colleges that served as study centres. The study subjects were employees (selected by age and sex stratified random sampling) and their family members. Information on behavioural, clinical and biochemical determinants was obtained through standardized methods (questionnaires, clinical measurements and biochemical analysis). Data collation and analyses were done at the national coordinating centre. FINDINGS: We report the prevalence of CVD risk factors among individuals aged 20-69 years (n = 19 973 for the questionnaire survey, n = 10 442 for biochemical investigations); mean age was 40 years. The overall prevalence of most risk factors was high, with 50.9% of men and 51.9% of women being overweight, central obesity was observed among 30.9% of men and 32.8% of women, and 40.2% of men and 14.9% of women reported current tobacco use. Self-reported prevalence of diabetes (5.3%) and hypertension (10.9%) was lower than when measured clinically and biochemically (10.1% and 27.7%, respectively). There was marked heterogeneity in the prevalence of risk factors among the study centres. CONCLUSION: There is a high burden of CVD risk factors among industrial populations across India. The surveillance system can be used as a model for replication in India as well as other developing countries. PMID:16799730

  2. Can noise cause high blood pressure? Occupational risk in paper industry.

    PubMed

    Sancini, A; Caciari, T; Rosati, M V; Samperi, I; Iannattone, G; Massimi, R; Loreti, B; Scala, B; Sacco, C; Tomei, F; Tomei, G

    2014-01-01

    The authors hypothesize cardiovascular effects in paper industry workers exposed to noise. The study included 72 paper industry workers exposed to noise and two control groups not exposed to noise. The workers completed a questionnaire and underwent a medical examination, measurement of blood pressure, electrocardiogram, blood tests, audiometry and measurement of noise exposure. The workers exposed to noise, all hearing impaired, were compared with not exposed and showed: significant increase of mean systolic and diastolic blood pressure values (p<0.001), higher frequency of hypertension, systolic and diastolic blood pressure (p<0.01 and p<0.001) and electrocardiografic abnormalities (p<0.05), significant reduction of blood pressure response in orthostatism (p<0.005). Our results suggest that for the workers of the paper industry the noise is an occupational risk factor for cardiovascular effects.

  3. Reference values of fetal erythrocytes in maternal blood during pregnancy established using flow cytometry.

    PubMed

    de Wit, Harry; Nabbe, Karin C A M; Kooren, Jurgen A; Adriaansen, Henk J; Roelandse-Koop, Elianne A; Schuitemaker, Joost H N; Hoffmann, Johannes J M L

    2011-10-01

    The aim of our study was to assess the fetal RBC count in maternal blood during uncomplicated pregnancies from 26 weeks onward. We used a flow cytometric method specifically designed for use in a routine hematology analyzer. Pregnant women were recruited through midwives. The participating laboratories used the FMH QuikQuant method (Trillium Diagnostics, Brewer, ME) in a CELL-DYN Sapphire hematology analyzer (Abbott Diagnostics, Santa Clara, CA). The method is based on a monoclonal antibody to hemoglobin F. Flow cytometric data were analyzed by 2 independent observers. The 95th percentile reference range was estimated according to Clinical and Laboratory Standards Institute guidelines. A total of 236 samples were statistically analyzed. Gestational ages ranged from 21.6 to 41 weeks (mean, 32.0 weeks), and the fetal RBC count in maternal blood ranged from 0.00% to 0.50% (median, 0.025%). The fetal RBC count in maternal blood shows no correlation with gestational age. The established reference range during normal pregnancy is less than 0.125%.

  4. Industrial Sites Project Establishment of Final Action Levels, Rev. No.: 0

    SciTech Connect

    Boehlecke, Robert F.

    2006-02-01

    The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) oversees numerous sites on the Nevada Test Site (NTS) and other locations in the State of Nevada that have been impacted by activities related to the development and testing of nuclear devices and by other activities. NNSA/NSO is responsible for protecting members of the public, including site workers, from harmful exposure to both chemical and radiological contaminants at these sites as they remediate these sites. The Nevada Division of Environmental Protection (NDEP) is the primary state agency responsible for protection of human health and the environment with respect to chemical and radiological wastes. In 1996 the DOE, U.S. Department of Defense, and the State of Nevada entered into an agreement known as the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Appendix VI to the FFACO describes the strategy employed to plan, implement, and complete environmental corrective action activities at NTS and other locations in the state of Nevada. One of the categories of corrective action units (CAUs) is Industrial Sites, which consists of approximately 1,150 locations that may require some level of investigation and corrective action. To evaluate the need for the extent of corrective action at a particular site, NNSA/NSO assesses the potential impacts to receptors by comparing measurements of contaminant concentrations to risk-based (chemical) and dose-based (radionuclide) standards (action levels). Preliminary action levels (PALs) are established as part of the data quality objective (DQO) process, and are presented in one or more FFACO documents generated as part of the corrective action process. This document formally defines and clarifies the NDEP-approved process NNSA/NSO Industrial Sites Project uses to fulfill the requirements of the FFACO and state regulations. This process establishes final action levels (FALs) based on the risk

  5. [Molecular mechanism for the establishment of blood-vessel gateway for immune cells in the CNS.

    PubMed

    Murakami, Masaaki

    We have been studying about the molecular mechanism responsible for the establishment of the blood-vessel gateway through which immune cells enter the CNS. We have discovered three kinds of gateways in a multiple sclerosis model, EAE, based on the neural stimulations and named them the gravity-gateway reflex, electric-gateway reflex, and pain-gateway reflex, respectively. All gateway reflexes are involved in specific crosstalk between sensory-sympathetic pathways. For example, in the gravity-gateway reflex, gravity-mediated sensory stimulation via the soleus muscles activates fifth lumber(L5)dorsal loot ganglions to activate L5 sympathetic ganglions, which express norepinephrine at specific vessels of the L5 cord. We explain these three types of gateway reflexes in this chapter.

  6. Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells

    PubMed Central

    Kurita, Ryo; Suda, Noriko; Sudo, Kazuhiro; Miharada, Kenichi; Hiroyama, Takashi; Miyoshi, Hiroyuki; Tani, Kenzaburo; Nakamura, Yukio

    2013-01-01

    Transfusion of red blood cells (RBCs) is a standard and indispensable therapy in current clinical practice. In vitro production of RBCs offers a potential means to overcome a shortage of transfusable RBCs in some clinical situations and also to provide a source of cells free from possible infection or contamination by microorganisms. Thus, in vitro production of RBCs may become a standard procedure in the future. We previously reported the successful establishment of immortalized mouse erythroid progenitor cell lines that were able to produce mature RBCs very efficiently. Here, we have developed a reliable protocol for establishing immortalized human erythroid progenitor cell lines that are able to produce enucleated RBCs. These immortalized cell lines produce functional hemoglobin and express erythroid-specific markers, and these markers are upregulated following induction of differentiation in vitro. Most importantly, these immortalized cell lines all produce enucleated RBCs after induction of differentiation in vitro, although the efficiency of producing enucleated RBCs remains to be improved further. To the best of our knowledge, this is the first demonstration of the feasibility of using immortalized human erythroid progenitor cell lines as an ex vivo source for production of enucleated RBCs. PMID:23533656

  7. An Analysis of Second-Tier Arms Producing Countries’ Offset Policies: Technology Transfer and Defense Industrial Base Establishment

    DTIC Science & Technology

    2008-03-01

    and those that rem of offsets to establish a defense industrial base in the recipient country defense offsets extensively since the 1970s (Perlo...the British/French Jaguar, the British/German/ Italian Tornado, and the French/German Alpha Jet emerged from Thus, the U.S. succeeded in achieving...Other indications of Brazil’s failure to establish self- production which were discussed in Chapter II include the Italian and components to equip their

  8. Blood chromium and nickel in relation to respiratory symptoms among industrial workers

    SciTech Connect

    Srivastava, A.K.; Gupta, B.N.; Mathur, N.; Rastogi, S.K.; Garg, N.; Chandra, S.V. )

    1992-06-01

    Seventy-eight workers exposed to fumes and dust of nickel and chromium in their occupation in the glass industry were studied for respiratory symptoms in relation to nickel and chromium concentrations in their blood. A significant (p less than 0.01) association was observed between respiratory symptoms and elevated blood nickel and chromium. An interaction between nickel and chromium was found in relation to the prevalence of respiratory symptoms.

  9. 75 FR 57963 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ...-13 (\\13\\C) urea breath and blood tests, and the urease test. This draft guidance has been updated... technologies outside the scope of the old guidance, such as H. pylori urea breath tests and H. pylori antigen... detection of H. pylori bacteria in human blood, serum, urine, stool, or breath specimens. FDA believes these...

  10. University-Industry Partnerships: A Study of How Top American Research Universities Establish and Maintain Successful Partnerships

    ERIC Educational Resources Information Center

    Prigge, George W.; Torraco, Richard J.

    2006-01-01

    This qualitative research study utilized the grounded theory tradition to examine organizational structures and processes in a purposefully selected sample of American universities that have established and maintained partnerships with industry. Institutional leaders from the corporate relations offices from fifteen of the top research…

  11. Establishing an Alaskan birch syrup industry: Birch Syrup—It’s the Un-maple!TM

    Treesearch

    Marlene. Cameron

    2001-01-01

    Ten years ago a small group of Alaskans began commercial production of birch syrup from the sap of the paper birch, Betula papyrifera, and established an industry that is expanding in response to demand and has the potential to make a significant contribution to Alaska's economy. There are still many problems to be solved; research and...

  12. 76 FR 66040 - Announcement of Meeting To Explore Feasibility of Establishing a NIST/Industry Consortium on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... Establishing a NIST/Industry Consortium on ``Concrete Rheology: Enabling Metrology (CREME)'' AGENCY: National... Institute of Standards and Technology (NIST) invites interested parties to attend a pre-consortium meeting on November 8, ] 2011 to be held at the NIST campus, with the option of participating via web-based...

  13. 76 FR 569 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... Staff; Establishing the Performance Characteristics of Nucleic Acid- Based In Vitro Diagnostic Devices... ``Establishing the Performance Characteristics of Nucleic Acid-Based In vitro Diagnostic Devices for the... recommendations for studies to establish the analytical and clinical performance of nucleic acid-based in...

  14. [Innovative urology needs innovative pharmaceuticals and technology: new cooperation established between BDU and industry].

    PubMed

    Ex, P; Schroeder, A

    2013-08-01

    For some time now medical care has been confronted with great challenges. New developments in the healthcare system result in new possibilities for cooperation in which the Professional Association of German Urologists (BDU) must participate. This is also true with respect to the Pharmaceutical Market Revision Act (AMNOG). The Industry Advisory Board aims to continuously observe and analyze the healthcare political and medical care political developments in Germany and Europe. The Professional Association has created room for a transparent cooperation with the Industry Advisory Board. The AMNOG which came into effect in 2011 also opened integrated contracts for businesses in the pharmaceutical industry.

  15. [Establishment of industry promotion technology system in Chinese medicine secondary exploitation based on "component structure theory"].

    PubMed

    Cheng, Xu-Dong; Feng, Liang; Zhang, Ming-Hua; Gu, Jun-Fei; Jia, Xiao-Bin

    2014-10-01

    The purpose of the secondary exploitation of Chinese medicine is to improve the quality of Chinese medicine products, enhance core competitiveness, for better use in clinical practice, and more effectively solve the patient suffering. Herbs, extraction, separation, refreshing, preparation and quality control are all involved in the industry promotion of Chinese medicine secondary exploitation of industrial production. The Chinese medicine quality improvement and industry promotion could be realized with the whole process of process optimization, quality control, overall processes improvement. Based on the "component structure theory", "multi-dimensional structure & process dynamic quality control system" and systematic and holistic character of Chinese medicine, impacts of whole process were discussed. Technology systems of Chinese medicine industry promotion was built to provide theoretical basis for improving the quality and efficacy of the secondary development of traditional Chinese medicine products.

  16. Establishing an eastern broccoli industry: where are we and where do we need to go?

    USDA-ARS?s Scientific Manuscript database

    A Coordinated Agricultural Project (CAP) entitled “Establishing an Eastern Broccoli Industry” has been underway since the fall of 2010 and funded under the USDA Specialty Crop Research Initiative (SCRI), which was established as part of the 2008 Farm Bill. This project has brought together research...

  17. 76 FR 72951 - Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ...; Establishing the Performance Characteristics of In Vitro Diagnostic Devices for the Detection or Detection and... ``Establishing the Performance Characteristics of In Vitro Diagnostic Devices for the Detection or Detection and...) intended for the ] detection, or detection and differentiation, of human papillomaviruses. DATES: Submit...

  18. [Computer-assisted management of depots for blood products in health establishments].

    PubMed

    Carré, J

    2008-11-01

    To manage the filing of blood components at the hospital of the city of Bayeux, the laboratory uses Cursus, a dedicated software for haemovigilance. Benefits for using this software at different steps of the blood bank management are: simplification, security and harmonization of practices during receipt and issurance of blood components, securing recordings with the use of bar codes for patient identification and blood components listing, implementation of a computerized tracking system for transfusion, traceability, limitation of written documents and availability of statistics on the management of the depot.

  19. 76 FR 41803 - Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... Differentiation of Influenza Viruses; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... Differentiation of Influenza Viruses.'' FDA is issuing this guidance to inform industry and Agency staff of its... diagnostic devices intended for the detection or detection and differentiation of influenza viruses. DATES...

  20. Establishing policies for the relationship between industry and clinicians: lessons learned from two academic health centers.

    PubMed

    Coleman, David L

    2008-09-01

    The relationship between faculty in academic health centers (AHCs) and commercial entities is critically important to improving the public health, yet it may be prone to conflicts of interest that adversely affect medical education, research, and clinical care. The Association of American Medical Colleges has recently recommended that medical schools and AHCs develop policies that better manage and occasionally prohibit interactions between academic medicine and industry. Because the development of more stringent policies is complex and potentially contentious, the author reports the lessons learned from developing new policies for the interactions between faculty and industry related to medical education and clinical care at Yale School of Medicine and Boston University School of Medicine/Boston Medical Center. The content of the policies was strongly influenced by the tenets of medical professionalism. Faculty support for new policies was strong, an iterative and inclusive process of formulation was critical, compromises in content were necessary, and the views of faculty concerning industry relationships were complex. After implementation of the new policies, the departmental food-related expenses increased, the loss of gifts was not appreciably missed, the faculty assumed more responsibility for educating trainees on the evaluation of new products, a central repository for receiving and evaluating grants from industry was useful, enforcement of the policies has been a lingering challenge, and the new policies generated positive publicity. Several recommendations are proposed. Creating these policies affirmed the importance of an inclusive process, open communication, support of institutional leadership, and focus on professional values.

  1. Briefing Paper regarding the Establishment of a Regional Technical and Industrial Skills Training Center.

    ERIC Educational Resources Information Center

    Powell, Roger Baden

    In spring 1997, Oregon's Regional Workforce Committee commissioned a study to investigate the feasibility of creating a technical and industrial skills training center in Region 12 of the state. Interviews were conducted with 40 individuals from area companies, social service agencies, and training organizations regarding the need for such a…

  2. Vocational Education's Role in Establishing Secondary Students in Business and Industry.

    ERIC Educational Resources Information Center

    Healas, Donald V.

    Vocational education does not create jobs, but rather is a force in readiness, meeting the demand for workers by the business-industrial complex. At the heart of the process of providing job opportunities to urban youth in Cleveland are the vocational teachers and teacher coordinators who have the primary responsibility for placement and followup.…

  3. 77 FR 10662 - Guidance for Industry: Questions and Answers Regarding Establishment and Maintenance of Records...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... Regarding Establishment and Maintenance of Records by Persons Who Manufacture, Process, Pack, Transport... by Persons Who Manufacture, Process, Pack, Transport, Distribute, Receive, Hold, or Import Food... of records by persons who manufacture, process, pack, transport, distribute, receive, hold, or...

  4. Risk factors affecting blood PCDDs and PCDFs in residents living near an industrial incinerator in Korea.

    PubMed

    Leem, J H; Lee, D S; Kim, J

    2006-10-01

    The contamination sources of polychlorinated dibenzodioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), such as industrial incinerators, can potentially change the blood levels and isomer patterns of PCDD/DFs in residents living near the incinerators. In this study, we estimated whether the blood levels and isomer patterns of PCDD/DFs in residents living near an incinerator were affected by its presence and investigated factors that characterize the risk of high exposure to PCDD/DFs in the area. We estimated the blood levels and homologue patterns of PCDD/DFs in a group of 40 residents living within 5 km of an industrial incinerator and in a group of 20 residents living 20 km away from an incinerator. We cannot assert that the operation of incinerator facilities was only cause of increased PCDD/DFs in these residents; however, the operation of incinerator facilities in agricultural areas increased PCDD/DF exposure to individuals. The group living next to the industrial incinerator especially represented the typical isomer pattern in which the proportions of OCDDs were lower and those of PCDFs higher than those in the other groups. The high-risk population with increased blood levels of PCDD/DFs included those who had lived longer in the contaminated area as well as those who frequently ate contaminated foods.

  5. 76 FR 34999 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... Methicillin-Resistant Staphylococcus Aureus for Culture-Based Devices; Availability AGENCY: Food and Drug... Diagnostic Devices for the Detection of Methicillin-Resistant Staphylococcus Aureus for Culture- Based... monitoring blood culture systems. This draft guidance is not final nor is it in effect at this time. DATES...

  6. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel Morrison; Sharon Elder

    2006-01-24

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the sixth quarterly technical progress report for the SWC. Key activities for this reporting period included: (1) Organized and hosted two technology transfer meetings; (2) Collaborated with the Pennsylvania Oil and Gas Association (POGAM) to host a Natural Gas Outlook conference in Pittsburgh, PA; (3) Provided a SWC presentation at the Interstate Oil and Gas Compact Commission (IOGCC) meeting in Jackson Hole, WY; and (4) Completed and released a stripper well industry documentary entitled: ''Independent Oil: Rediscovering America's Forgotten Wells''.

  7. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal.

    PubMed

    Benjamin, L E; Golijanin, D; Itin, A; Pode, D; Keshet, E

    1999-01-01

    Features that distinguish tumor vasculatures from normal blood vessels are sought to enable the destruction of preformed tumor vessels. We show that blood vessels in both a xenografted tumor and primary human tumors contain a sizable fraction of immature blood vessels that have not yet recruited periendothelial cells. These immature vessels are selectively obliterated as a consequence of vascular endothelial growth factor (VEGF) withdrawal. In a xenografted glioma, the selective vulnerability of immature vessels to VEGF loss was demonstrated by downregulating VEGF transgene expression using a tetracycline-regulated expression system. In human prostate cancer, the constitutive production of VEGF by the glandular epithelium was suppressed as a consequence of androgen-ablation therapy. VEGF loss led, in turn, to selective apoptosis of endothelial cells in vessels devoid of periendothelial cells. These results suggest that the unique dependence on VEGF of blood vessels lacking periendothelial cells can be exploited to reduce an existing tumor vasculature.

  8. 76 FR 570 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... Staff; Establishing the Performance Characteristics of In Vitro Diagnostic Devices for the Detection of... Characteristics of In Vitro Diagnostic Devices for the Detection of Antibodies to Borrelia burgdorferi.'' FDA is... detection of antibodies to Borrelia burgdorferi. These devices are used to aid in the diagnosis of Lyme...

  9. [Correlation of protoporphyrin zinc with lead in blood in workers of the car batteries industry in Bogota, Colombia].

    PubMed

    Cárdenas-Bustamante, O; Varona-Uribe, M E; Núñez-Trujillo, S M; Ortiz-Varón, J E; Peña-Parra, G E

    2001-01-01

    To determine the usefulness of zinc protoporphyrin in blood (PPz) as an indicator of lead exposure in workers of the homemade car battery industry. A cross-sectional study was performed in 116 workers of the car battery industry in Bogotá, Colombia. Data on general, occupational, and health variables were collected by interview. Two categories of PPz values were established: Those below the cutoff value (70 micrograms/dL) and those above it. A linear regression analysis was performed to measure the correlation between logarithm values of PPz (> 70 micrograms/dL) and lead in blood (PbB) (> 38 micrograms/dL). A semi-logarithmic correlation coefficient of r = 0.54 was found, and statistically significant associations between high levels of PPz and direct exposure to lead were observed (OR: 3.35, 95% IC 1.02-11.91; p: 0.02); for workers who often use lead as a raw material (OR: 7.80, 95% IC 2.96-21.03; p < 0.01), as well as for workers who do not change work clothes often (OR: 3.55, 95% IC 1.17-11.01; p < 0.01). PPz may be a useful diagnostic indicator for lead poisoning; it may also be used as a screening test for surveillance programs in the biological monitoring of workers exposed to lead.

  10. Building healthy communities: establishing health and wellness metrics for use within the real estate industry.

    PubMed

    Trowbridge, Matthew J; Pickell, Sarah Gauche; Pyke, Christopher R; Jutte, Douglas P

    2014-11-01

    It is increasingly well recognized that the design and operation of the communities in which people live, work, learn, and play significantly influence their health. However, within the real estate industry, the health impacts of transportation, community development, and other construction projects, both positive and negative, continue to operate largely as economic externalities: unmeasured, unregulated, and for the most part unconsidered. This lack of transparency limits communities' ability to efficiently advocate for real estate investment that best promotes their health and well-being. It also limits market incentives for innovation within the real estate industry by making it more difficult for developers that successfully target health behaviors and outcomes in their projects to differentiate themselves competitively. In this article we outline the need for actionable, community-relevant, practical, and valuable metrics jointly developed by the health care and real estate sectors to better evaluate and optimize the "performance" of real estate development projects from a population health perspective. Potential templates for implementation, including the successful introduction of sustainability metrics by the green building movement, and preliminary data from selected case-study projects are also discussed.

  11. Establishing a public umbilical cord blood stem cell bank for South Africa: an enquiry into public acceptability.

    PubMed

    Meissner-Roloff, Madelein; Pepper, Michael S

    2013-12-01

    South Africa (SA) faces a large unmet need for bone marrow (BM) transplantation, which could be alleviated in part by establishing a public umbilical cord blood stem cell bank (UCB SCB). Umbilical cord blood is an increasingly utilised source of hematopoietic stem cells for BM transplantation in addition to BM or mobilized peripheral blood stem cells. Establishing a public UCB SCB would therefore be a positive step towards improving the quality of health care in SA by providing for an important unmet need. This study takes the form of an enquiry into the acceptability of establishing a public bank through an interview with and questionnaire completed by mothers-to-be in the antenatal clinic of a large public hospital in SA. Initial results are positive, with 85 % of the participants in favour of establishing a public UCB SCB in SA. This initial probe will serve as a model for a more comprehensive national enquiry into public support and acceptability in different clinics, hospitals and provinces in SA.

  12. Enablers towards establishing and growing South Africa's waste to electricity industry.

    PubMed

    Amsterdam, Heinrich; Thopil, George Alex

    2017-10-01

    In South Africa the electricity generation mix is relatively un-diverse whereas globally the transformation of the sector is advancing rapidly. Coal remains the predominant fuel source and limited success has to date been achieved in the renewable energy sector. The electricity generation sector is therefore hindered from moving towards an electricity generation landscape where alternative fuel sources is utilised. This research is aimed at gaining insight into the enablers that led towards an increasing trend (observed globally) in exploiting waste as a fuel for electricity generation, and to outline the presence of obstacles that hinder separation of waste for electricity use in the South African context. Furthermore it is an attempt at informing what appropriate interventions (operational and policy) may be considered suitable for South Africa to overcome these barriers in order to enable a sustainable South African waste to electricity (WTE) Industry. Findings show that numerous barriers to a WTE exists in the South African context, however overcoming these barriers is not as simple as adopting the European model with the aim to modify the electricity generation mix and waste management landscape. Selected enablers deemed appropriate in the South African context are adapted from the European model, and are greatly influenced by the prevailing socio-economic status of South Africa. Primary enablers identified were, (i) government support is needed especially in the form of subsidisation for green energy, (ii) increase landfill costs through the implementation of a landfill tax, (iii) streamline the process for Independent Private Power Producers (IPPPs) to connect to the national grid with off-take guaranteed and the inclusion of WTE into an electricity roadmap (effectively government's strategy). The proposed enabling interventions would help in overcoming the barriers for a South African WTE industry. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Key issues for establishing a robotics laboratory in the pharmaceutical industry

    PubMed Central

    Conder, Steve

    1994-01-01

    The Analytical Research and Development Department of Bristol-Myers Squibb has a laboratory dedicated to robotic analysis of solid dose forms. It consists of eight individuals responsible for nine robotic systems. The laboratory is dedicated to the support of Phase III stability studies that require dissolution, potency, content. uniformity and Karl Fischer moisture assays. The group performs about 15000 assays a year for approximately six long-term stability programs. The key issues for success were personnel selection, methods development (methods transfer), routine assay support, documentation, validation, training and support services. This paper discusses the establishment of the laboratory and the future issues important to continued success. PMID:18924996

  14. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2001-09-14

    The Pennsylvania State University, under contract to the US Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the US petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the four quarterly technical progress report for the SWC. During this reporting period, Penn State primary focus was on finalizing all subcontracts, planning the SWC technology transfer meeting and two workshops in the southern US, and preparing the next SWC newsletter. Membership in the SWC now stands at 49.

  15. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2002-09-27

    The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL), will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the eighth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) issuing subcontracts, (2) SWC membership class expansion, (3) planning SWC technology transfer meetings, and (4) extending selected 2001 project periods of performance. In addition, a literature search that focuses on the use of lasers, microwaves, and acoustics for potential stripper well applications continued.

  16. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2003-04-08

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the ninth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) organizing and hosting two fall technology transfer meetings, (2) SWC membership class expansion, and (3) planning the SWC 2003 Spring meeting. In addition, a literature search that focuses on the use of lasers, microwaves, and acoustics for potential stripper well applications continued.

  17. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel L. Morrison; Sharon L. Elder

    2006-04-21

    The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL) has established a national industry-driven Stripper Well Consortium (SWC) that is focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the seventh quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) Nomination and election of the Executive Council members for the 2006-07 term, (2) Finalize and release the 2006 Request for Proposals (RFP), (3) Invoice and recruit members, (4) Plan for the spring meeting, (5) Improving communication efforts, and (6) Continue distribution of the DVD entitled: ''Independent Oil: Rediscovering American's Forgotten Wells''.

  18. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel L. Morrison; Sharon L. Elder

    2006-05-01

    The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL) established a national industry-driven Stripper Well Consortium (SWC) that is focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the eighth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) Organize and host the 2006 Spring Meeting in State College, PA to review and select projects for SWC co-funding; (2) Participation in the 2006 PA CleanEnergy Expo Energy Theater to air the DVD on ''Independent Oil: Rediscovering American's Forgotten Wells''; (3) New member additions; (4) Improving communications; and (5) Planning of the fall technology meetings.

  19. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2005-01-04

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the seventeenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) organizing and hosting the SWC fall technology transfer meetings in Oklahoma City, Oklahoma and State College, Pennsylvania, (2) planning of the upcoming SWC spring proposal meeting, (3) release of the SWC Request-for-proposals (RFP), (4) revision of the SWC By-Laws, and (5) the SWC Executive Council nomination and election for 2005-2006 term members.

  20. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel L. Morrison

    2005-08-26

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the eighteenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) prepare presentation for the 16th Annual Oil Recovery Conference in Wichita, Kansas, (2) continued working on the SWC technical bulletin ''Keeping the Home Wells Flowing: Helping Small Independent Oil and Gas Producers Develop New Technology Solutions'', (3) continue efforts on the Public Broadcast of Independent Oil: Rediscovering America's Forgotten Wells, and (4) continue efforts to recruit SWC members.

  1. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-12-28

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the first quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) hosting the SWC spring proposal meeting in Golden Colorado, (2) planning of the upcoming SWC fall technology transfer meetings, and (3) recruiting the SWC base membership.

  2. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-12-23

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the fifteenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) hosting the SWC spring proposal meeting in Golden Colorado, (2) planning of the upcoming SWC fall technology transfer meetings, and (3) recruiting the SWC base membership.

  3. [Work organisation improvement methods applied to activities of Blood Transfusion Establishments (BTE): Lean Manufacturing, VSM, 5S].

    PubMed

    Bertholey, F; Bourniquel, P; Rivery, E; Coudurier, N; Follea, G

    2009-05-01

    Continuous improvement of efficiency as well as new expectations from customers (quality and safety of blood products) and employees (working conditions) imply constant efforts in Blood Transfusion Establishments (BTE) to improve work organisations. The Lean method (from "Lean" meaning "thin") aims at identifying wastages in the process (overproduction, waiting, over-processing, inventory, transport, motion) and then reducing them in establishing a mapping of value chain (Value Stream Mapping). It consists in determining the added value of each step of the process from a customer perspective. Lean also consists in standardizing operations while implicating and responsabilizing all collaborators. The name 5S comes from the first letter of five operations of a Japanese management technique: to clear, rank, keep clean, standardize, make durable. The 5S method leads to develop the team working inducing an evolution of the way in the management is performed. The Lean VSM method has been applied to blood processing (component laboratory) in the Pays de la Loire BTE. The Lean 5S method has been applied to blood processing, quality control, purchasing, warehouse, human resources and quality assurance in the Rhône-Alpes BTE. The experience returns from both BTE shows that these methods allowed improving: (1) the processes and working conditions from a quality perspective, (2) the staff satisfaction, (3) the efficiency. These experiences, implemented in two BTE for different processes, confirm the applicability and usefulness of these methods to improve working organisations in BTE.

  4. An Approach to Industrial Stormwater Benchmarks: Establishing and Using Site-Specific Threshold Criteria at Lawrence Livermore National Laboratory

    SciTech Connect

    Campbell, C G; Mathews, S

    2006-09-07

    Current regulatory schemes use generic or industrial sector specific benchmarks to evaluate the quality of industrial stormwater discharges. While benchmarks can be a useful tool for facility stormwater managers in evaluating the quality stormwater runoff, benchmarks typically do not take into account site-specific conditions, such as: soil chemistry, atmospheric deposition, seasonal changes in water source, and upstream land use. Failing to account for these factors may lead to unnecessary costs to trace a source of natural variation, or potentially missing a significant local water quality problem. Site-specific water quality thresholds, established upon the statistical evaluation of historic data take into account these factors, are a better tool for the direct evaluation of runoff quality, and a more cost-effective trigger to investigate anomalous results. Lawrence Livermore National Laboratory (LLNL), a federal facility, established stormwater monitoring programs to comply with the requirements of the industrial stormwater permit and Department of Energy orders, which require the evaluation of the impact of effluent discharges on the environment. LLNL recognized the need to create a tool to evaluate and manage stormwater quality that would allow analysts to identify trends in stormwater quality and recognize anomalous results so that trace-back and corrective actions could be initiated. LLNL created the site-specific water quality threshold tool to better understand the nature of the stormwater influent and effluent, to establish a technical basis for determining when facility operations might be impacting the quality of stormwater discharges, and to provide ''action levels'' to initiate follow-up to analytical results. The threshold criteria were based on a statistical analysis of the historic stormwater monitoring data and a review of relevant water quality objectives.

  5. Air pollution from industrial swine operations and blood pressure of neighboring residents.

    PubMed

    Wing, Steve; Horton, Rachel Avery; Rose, Kathryn M

    2013-01-01

    Industrial swine operations emit odorant chemicals including ammonia, hydrogen sulfide (H2S), and volatile organic compounds. Malodor and pollutant concentrations have been associated with self-reported stress and altered mood in prior studies. We conducted a repeated-measures study of air pollution, stress, and blood pressure in neighbors of swine operations. For approximately 2 weeks, 101 nonsmoking adult volunteers living near industrial swine operations in 16 neighborhoods in eastern North Carolina sat outdoors for 10 min twice daily at preselected times. Afterward, they reported levels of hog odor on a 9-point scale and measured their blood pressure twice using an automated oscillometric device. During the same 2- to 3-week period, we measured ambient levels of H2S and PM10 at a central location in each neighborhood. Associations between systolic and diastolic blood pressure (SBP and DBP, respectively) and pollutant measures were estimated using fixed-effects (conditional) linear regression with adjustment for time of day. PM10 showed little association with blood pressure. DBP [β (SE)] increased 0.23 (0.08) mmHg per unit of reported hog odor during the 10 min outdoors and 0.12 (0.08) mmHg per 1-ppb increase of H2S concentration in the same hour. SBP increased 0.10 (0.12) mmHg per odor unit and 0.29 (0.12) mmHg per 1-ppb increase of H2S in the same hour. Reported stress was strongly associated with BP; adjustment for stress reduced the odor-DBP association, but the H2S-SBP association changed little. Like noise and other repetitive environmental stressors, malodors may be associated with acute blood pressure increases that could contribute to development of chronic hypertension.

  6. Blood biomonitoring of metals in subjects living near abandoned mining and active industrial areas.

    PubMed

    Madeddu, Roberto; Tolu, Paola; Asara, Yolande; Farace, Cristiano; Forte, Giovanni; Bocca, Beatrice

    2013-07-01

    A human blood biomonitoring campaign to detect the environmental exposure to metals (Cd, Cu, Cr, Mn, Pb and Zn) in 265 subjects was performed in the South-Western part of Sardinia (an Italian island) that is a particular area with a great history of coal and metal mining (Pb/Zn mainly) activities and large industrial structures (as metallurgy). Subjects living near the industrial plant area had geometric means (GM) of blood Cd (0.79 μg/l), Cu (971 μg/l), Mn (12.2 μg/l), and Pb (55.7 μg/l) significantly higher than controls (Cd, 0.47 μg/l; Cu, 900 μg/l; Mn 9.98 μg/l; Pb, 26.5 μg/l) and than people living nearby the past mining sites. Subjects living next to one dismissed mine were statistically higher in blood Cu (GM, 1,022 μg/l) and Pb (GM, 41.4 μg/l) concentrations than controls. No differences were observed in people living in the different mining sites, and this might be related to the decennial disclosure of mines and the adoption of environmental remediation programmes. Some interindividual variables influenced blood biomonitoring data, as smoke and age for Cd, gender for Cu, age, sex and alcohol for Pb, and age for Zn. Moreover, blood metal levels of the whole population were similar to reference values representative of the Sardinian population and acceptably safe according to currently available health guidelines.

  7. 78 FR 38994 - Implanted Blood Access Devices for Hemodialysis; Draft Guidance for Industry and Food and Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... HUMAN SERVICES Food and Drug Administration Implanted Blood Access Devices for Hemodialysis; Draft Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing...

  8. HLA, blood groups and secretor status in patients with established rheumatic fever and rheumatic heart disease.

    PubMed

    Jhinghan, B; Mehra, N K; Reddy, K S; Taneja, V; Vaidya, M C; Bhatia, M L

    1986-03-01

    The distribution of HLA-A, -B and -DR antigens as well as blood groups and secretor status was studied in sporadic, North Indian patients of rheumatic fever and rheumatic heart disease. While HLA-Aw33 occurred with an increased frequency in the patient group (X2 = 4.01), no statistically significant differences were observed in the frequency of B-locus antigens. In the DR locus, HLA-DR3 was found to be significantly increased (50% vs 26.1%, X2 = 13.8) and DR2 significantly reduced (21.8% vs 47.0%, X2 = 15.6). Also, there was a preponderance of non-'O' blood group individuals in the patient group as compared to controls. The DR3 association was significant only in those patients of RHD who did not have any previous history of rheumatic fever. These results indicate that susceptibility to rheumatic heart disease is HLA-class II mediated, with HLA-DR3 influencing susceptibility and DR2 conferring protection.

  9. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2001-06-28

    The Pennsylvania State University, under contract to the US Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the US petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the first quarterly technical progress report for the SWC. The SWC is in its infancy; however, interest from the petroleum and natural gas industry has grown substantially during this reporting period. As of December 31, 2000, nineteen members have joined the consortium and several other companies have expressed interest. During the last three months, efforts were focused on the development of the necessary infrastructure and membership base to begin the consortium technology development activities. These efforts included: (1) preparing a draft constitution and bylaws, (2) developing draft membership application forms, (3) developing an intellectual property statement, (4) providing overview presentations to trade association meetings, and (5) marketing the consortium individually to potential members. These activities are discussed in further detail in this first quarterly technical progress report.

  10. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-05-10

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the tenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) release of the 2003 request-for-proposal (RFP), (2) planning the spring SWC meeting in Pearl River New York, and (3) tentatively plan the SWC 2003 fall technology transfer meetings. During this reporting period, the efforts were focused primarily on the organizing and hosting the fall technology transfer meetings. Simultaneously, administrative issues such as modifying the SWC Constitution and By-Laws and creating a block membership tier to promote further industrial involvement were areas of concentration. The SWC is poised to enter its third year with a growing, diversifying membership.

  11. Exploring pharmacist-customer communication: the established blood pressure measurement episode.

    PubMed

    Cavaco, Afonso Neves; Romano, João P

    2010-10-01

    To characterize the communication ritual in the pharmacist-customer dyad during a blood pressure measurement and counselling episode. A Portuguese urban community pharmacy. An exploratory, cross-sectional design was used. Participants were purposively selected and data collected via audio recording, as well as demographics and clinical information via questionnaire. Encounters' verbal content was transcribed verbatim, utterances identified, time stamped, and classified according to a coding scheme of fifteen categories. All data was statistically analyzed using SPSSv17. Four dialogue structures: speaker turn, interactivity, turn density and turn duration measurements. From a total of 51 participants, 72.5% were female with a median age of 66 years. The average systolic blood pressure was 140 mmHg, while the diastolic was 78 mmHg. The blood pressure measurement episode lasted for 5:35 min, with an average of 81 utterances. From all utterances registered, 55.3% were produced by the customer. Visits averaged 38 speaker turns, with an interactivity rate of approximately 7 turns per episode minute. For pharmacists, turn duration averaged 7.0 s and turn density 2.1 utterances. The customers' turns comprised a mean of 8.0 s, with 2.4 utterances. Longer episodes were related to more speaker turns and greater customer turn density and duration, but lower dialogue interactivity. The interactivity rate was also lower when the customers' utterances increased. Pharmacists asked more questions (essentially closed ones), while the customers gave more information. No significant associations were observed between elderly/non-elderly and gender in relation to all communication variables. However, an increased number of speaker turns and closed-questions were associated to a higher systolic pressure. It seems that pharmacists tend to control the content of the dialogue, while customers have more influence on the visit duration and interactivity. Specific hypertensive episodes induce

  12. LDL particle heterogeneity, and its association with other established cardiovascular risk factors in a young Indian industrial population

    PubMed Central

    Lakshmy, Ramakrishnan; Dorairaj, Prabhakaran; Tarik, Mohamad; Gupta, Ruby; Reddy, Kolli Srinath

    2012-01-01

    Objective Low density lipoprotein (LDL) particles are heterogeneous in terms of size, density, chemical composition and electric charge with certain particle of LDL being more atherogenic than the others. The present study aimed to look at the LDL particle heterogeneity, particle size and association with other cardiovascular disease (CVD) risk factors in young Indian industrial population. Methodology 600 employees of an industry of Delhi, aged 20-39 years were selected for the study. Data on demographics, individual characteristics associated with major risk factors of CVD, past medical history, clinical and anthropometric profile was collected. Fasting glucose, lipid profile, apolipoprotein (A1, B, and E), lipoprotein (a), high sensitive C-reactive protein (hsCRP) and insulin were estimated. LDL particle size was determined in ethylenediamminetetraacetate (EDTA) plasma by 3% polyacrylamide gel electrophoresis. Result We found a prevalence of small dense LDL phenotype (LDL size ≤ 26.3) in 27.4% of males and 24.0% of females. The mean waist circumference, blood pressure, triglycerides (TAG), cholesterol, hsCRP, apolipoprotein (A1, B and E) and insulin were higher in males whereas mean high density lipoprotein was higher in females. Females also had a significantly higher mean LDL particle diameter as compared to males. Conclusion TAG, physical activity and lipoprotein (a) correlated with small dense LDL in this young Indian population. PMID:27326051

  13. Dietetics at work in the workplace: academia and industry cooperate in a blood pressure program.

    PubMed

    Wagstaff, M A; Wagner, K

    1985-04-01

    Here is one approach to the challenge of preparing dietetic students for a rapidly changing health care system. Hypertension screening and control are the focus of a cooperative project conducted at the Saginaw-Detroit plants of General Motors Corporation by students of the Medical Dietetics Program at Wayne State University, Detroit. The project reflects implementation, over a 3-year period, of the General Motors Blood Pressure Program. A model is presented for involving students in a health-oriented program at a work site. Effectiveness of student follow-up and counseling is demonstrated in a research component involving noncompliant hypertensive employees. Outcomes of cooperative efforts include: (a) development of guidelines for management of a hypertension monitoring program involving students, (b) support for an industrial medical staff in mounting a new program, (c) extension of faculty capabilities through plant medical staff, (d) baseline data for calculating cost-benefit of a monitoring program, and (e) achievement of superior blood pressure control in comparison with other industrial programs.

  14. Specific relationship between blood lead and air lead in the crystal industry.

    PubMed

    Pierre, Francis; Vallayer, Cécile; Baruthio, François; Peltier, Arlette; Pale, Sylvie; Rouyer, Joël; Goutet, Pierre; Aubrège, Bernadette; Lecossois, Colette; Guillemin, Christine; Elcabache, Jean-Marie; Verelle, Brigitte; Fabriès, Jean-François

    2002-04-01

    The main objective of the study was to establish the consequences of exposure to crystal dust on blood lead level in workers employed in hand-finishing and grinding crystal pieces. The second objective was to research a relationship between ambient air lead and blood lead. A study conducted in eastern France on 131 subjects occupationally exposed to an aerosol containing crystal particles involved personal measurements of atmospheric exposure to lead, determination of blood lead and, by questionnaire, collection of personal data on exposure characteristics, state of health and level of hygiene of survey volunteers. Initial analysis showed that differences in exposure at the workplace corresponded to differences in blood lead in the operators. There was definitely a potential risk of overexposure to lead, but the existence of this risk was not confirmed by level of blood lead concentrations and, moreover, no clinical signs of lead poisoning in the employees exposed were revealed. The existence of a relationship between personal air (PbA) and blood lead (PbB) levels in grinders and polishers was demonstrated. This relationship, of the form log PbB=2.064+0.181 x log PbA, turns out to be different from those provided by previously published models, which were developed from studies conducted in lead-acid battery manufacturing plants and form the basis of national regulations. Thus, chronic exposure at 100 microg/m(3) of lead at a crystal-grinding workshop corresponds to a mean PbB level of 270 microg/l, whereas the recognized models estimate 350 to 500 microg/l. This study revealed a specific risk for these categories of exposed individuals. The origin of the descriptive model obtained for the lead exposure/ PbB level relationship raises, through the example of lead, the more general problem of the need to take into account differentiation of chemical substances containing the same element in biological monitoring.

  15. Lead exposure and blood pressure among workers in diverse industrial plants in Kenya.

    PubMed

    Were, Faridah H; Moturi, M Charles; Gottesfeld, P; Wafula, Godfrey A; Kamau, Geoffrey N; Shiundu, Paul M

    2014-01-01

    The study evaluated airborne exposures and blood lead (BPb) levels in 233 production workers at six diverse industrial plants in Kenya. Blood and personal breathing zone air samples were collected and analyzed for lead (Pb) using atomic absorption spectroscopy. Blood pressure (BP) levels were measured using a standard mercury sphygmomanometer. The results indicated mean airborne Pb levels ± standard deviation (SD) as follows: 183.2 ± 53.6 μg/m(3) in battery recycling, 133.5 ± 39.6 μg/m(3) in battery manufacturing, 126.2 ± 39.9 μg/m(3) in scrap metal welding, 76.3 ± 33.2 μg/m(3) in paint manufacturing, 27.3 ± 12.1 μg/m(3) in a leather manufacturing, and 5.5 ± 3.6 μg/m(3) in a pharmaceutical plant. The mean airborne Pb levels exceeded the U.S. Occupational Safety and Health Administration (OSHA) 8-hr time-weighted average (TWA) permissible exposure limit (PEL) for Pb of 50 μg/m(3) in the battery manufacturing, battery recycling, welding, and paint manufacturing plants. Similarly, mean BPb concentrations exceeded the American Conference of Governmental Industrial Hygienists (ACGIH®) biological exposure index (BEI) for Pb of 30 μg/dl. A significant positive association was observed between BPb and breathing zone air Pb (R(2) = 0.73, P < 0.001). Approximately 30% of the production workers (N = 233) were in the hypertensive range with an average systolic and diastolic blood pressure (BP) of 134.7 ± 12.7 mmHg and 86.4 ± 8.9 mmHg, respectively. In the multivariate regression analysis, age, duration of work, airborne Pb and BPb levels were significantly associated (P < 0.05) with a change in BP. We recommend improved engineering controls, work practices, and personal hygiene to reduce Pb exposures. In addition, workers should undergo comprehensive medical surveillance to include BPb and BP testing, and airborne Pb assessments in all industries with significant lead exposures.

  16. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2002-09-30

    The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL), has established a national industry-driven Stripper Well Consortium (SWC) that is focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the second topical report. The SWC has grown and diversified its membership during its first 24 months of existence. The Consortium is now focused on building strategic alliances with additional industrial, state, and federal entities to expand further the SWC membership base and transfer technologies as they are developed. In addition, the Consortium has successfully worked to attract state support to co-fund SWC projects. Penn State has entered a co-funding arrangement with the New York State Energy Development Authority (NYSERDA) which has provided $200,000 over the last two years to co-fund stripper well production-orientated projects that have relevance to New York state producers. During this reporting period, the Executive Council approved co-funding for 14 projects that have a total project value of $2,116,897. Since its inception, the SWC has approved cofunding for 27 projects that have a total project value of $3,632,109.84. The SWC has provided $2,242,701 in co-funding for these projects and programmatically maintains a cost share of 39%.

  17. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2001-09-12

    The Pennsylvania State University, under contract to the US Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. the consortium creates a partnership with the US petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the third quarterly technical progress report for the SWC. During this reporting period the SWC entered into a co-funding arrangement with the New York State Energy Development Authority (NYSERDA) to provide an additional $100,000 in co-funding for stripper well production-orientated projects.The SWC hosted its first meeting in which members proposed research projects to the SWC membership. The meeting was held on April 9-10, 2001 in State College, Pennsylvania. Twenty three proposals were submitted to the SWC for funding consideration. Investigators of the proposed projects provided the SWC membership with a 20 minute (15 minute technical discussion, 5 minute question and answer session) presentation. Of the 23 proposals, the Executive Council approved $921,000 in funding for 13 projects. Penn State then immediately started the process of issuing subcontracts to the various projects approved for funding.

  18. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-05-10

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the eleventh quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) organizing and hosting the Spring SWC meeting in Pearl River, New York, (2) working with successful applicants and Penn State's Office of Sponsored Research to get subcontracts in place, and (3) planning three SWC technology transfer meetings to take place in the fall of 2003. During this reporting period, the efforts were focused primarily on the organizing and hosting the SWC Spring proposal meeting and organizing the fall technology transfer meetings.

  19. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2002-08-27

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the sixth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) release of 2002 SWC request-for-proposal, (2) organized and hosted the Spring SWC meeting in Columbus, Ohio for membership proposal presentations and review; (3) tentatively scheduled the 2002 fall technology transfer meeting sites, and (4) continued to recruit additional Consortium members. In addition, a literature search that focuses on the use of lasers, microwaves, and acoustics for potential stripper well applications continued.

  20. Establishment of experimental conditions for preserving samples of fish blood for analysis with both comet assay and flow cytometry.

    PubMed

    Ramsdorf, Wanessa A; Guimarães, Fernando de S F; Ferraro, Marcos V M; Gabardo, Juarez; Trindade, Edvaldo da Silva; Cestari, Marta Margarete

    2009-02-19

    When environmental analysis is performed, the high number of samples required and handling conditions during the transport of these samples to the laboratory are common problems. The comet assay is a useful, highly sensitive tool in biomonitoring. Some studies in the literature aim to preserve slides in lysis solution for use in the comet assay. Until now, however, no efficient methodology for preserving blood samples for this assay has been described. Because of this, the present report aimed to establish the proper conditions for samples maintenance prior to comet assay analysis. Samples were conserved in three different solutions: a high protein concentration solution (fetal bovine serum-FBS), an anticoagulant agent (a calcium chelator - ethylenediaminetetracetic acid - EDTA), and a salt buffered solution (phosphate buffered saline-PBS). Therefore, peripheral blood samples of Rhamdia quelen specimens were collected and maintained in these solutions until testing at 72h. Analyses of DNA fragmentation via the comet assay and cell viability via flow cytometry were performed at intervals of 24h. The results showed that samples maintained in FBS were preserved better; this was followed by those preserved in PBS and then last by those preserved in EDTA. In conclusion, blood samples from freshwater fish can be preserved up to 48h in fetal bovine serum at 4 degrees C in the absence of light. In this period, no DNA fragmentation occurs. We thus describe an excellent method of sample conservation for subsequent analysis in the laboratory.

  1. Effect of spontaneous running on blood pressure, heart rate and cardiac dimensions in developing and established spontaneous hypertension in rats.

    PubMed

    Hoffmann, P; Friberg, P; Ely, D; Thorén, P

    1987-04-01

    The effect of chronic voluntary exercise on resting blood pressure and heart rate was measured in two different age groups of spontaneously hypertensive rats (SHR). In the younger group, left ventricular dimensions were also measured. The younger group was 9 weeks old at the start of the experiment and was in a period of rapid blood-pressure rise. The older group, 13 weeks old at the start of the experiment, already had established hypertension. During a period of 6 weeks, the animals ran spontaneously in wheels mounted in their cages and reached a maximum of 6-7 km per 24 h. Age-matched, sedentary SHR were used as controls. Both groups of runners showed a decrease in body weight in comparison to controls. The younger runners exhibited a delayed onset of hypertension. They also showed a significantly increased left ventricular (LV) end-diastolic volume for every measured end-diastolic pressure between 7.5 mmHg and 20 mmHg (P less than 0.05). This suggests the development of a structural growth-dependent increase of the internal LV radius while LV weight and wall-to-lumen ratio were largely unaltered in younger runners compared with controls. In SHR with established hypertension, physical training did not reduce arterial blood pressure but heart rate was significantly lower than in the controls. These results thus indicate that an early onset of physical exercise in SHR may delay the development of hypertension. In addition, a more favourable cardiac design could also be seen.

  2. Empowering biotechnology in southern Africa: establishment of a robust transformation platform for the production of transgenic industry-preferred cassava.

    PubMed

    Chetty, C C; Rossin, C B; Gruissem, W; Vanderschuren, H; Rey, M E C

    2013-01-25

    Knowledge and technology transfer to African laboratories and farmers is an important objective for achieving food security and sustainable crop production on the sub-Saharan African continent. Cassava (Manihot esculenta Crantz) is a vital source of calories for more than a billion people in developing countries, and its potential industrial use for starch and bioethanol in the tropics is increasingly being recognized. However, cassava production remains constrained by the susceptibility of the crop to several biotic and abiotic stresses. For more than a decade, biotechnology has been considered an attractive tool to improve cassava as it substantially circumvents the limitations of traditional breeding, which is particularly time-consuming and tedious because of the high heterozygosity of the crop. A major constraint to the development of biotechnological approaches for cassava improvement has been the lack of an efficient and robust transformation and regeneration system. Despite some success achieved in genetic modification of the model cassava cultivar Tropical Manihot Series (TMS), TMS 60444, in some European and U.S. laboratories, the lack of a reproducible and robust protocol has not allowed the establishment of a routine transformation system in sub-Saharan Africa. In this study, we optimized a robust and efficient protocol developed at ETH Zurich to successfully establish transformation of a commercially cultivated South African landrace, T200, and compared this with the benchmark model cultivar TMS 60444. Results from our study demonstrated high transformation rates for both T200 (23 transgenic lines from 100 friable embryogenic callus (FEC) clusters) compared with TMS 60444 (32 transgenic lines from 100 FEC clusters). The success in transforming landraces or farmer-preferred cultivars has been limited, and the high transformation rate of an industry-preferred landrace in this study is encouraging for a feasible transformation program for cassava

  3. Benefits of Adding a Rapid PCR-Based Blood Culture Identification Panel to an Established Antimicrobial Stewardship Program

    PubMed Central

    2016-01-01

    Studies have demonstrated that the combination of antimicrobial stewardship programs (ASP) and rapid organism identification improves outcomes in bloodstream infections (BSI) but have not controlled for the incremental contribution of the individual components. Hospitalized adult patients with blood culture pathogens on a rapid, multiplex PCR-based blood culture identification panel (BCID) that included 19 bacterial species, 5 Candida spp., and 4 antimicrobial resistance genes were studied over sequential time periods in a pre-post quasiexperimental study in 3 groups in the following categories: conventional organism identification (controls), conventional organism identification with ASP (AS), and BCID with ASP (BCID). Clinical and economic outcomes were compared between groups. There were 783 patients with positive blood cultures; of those patients, 364 (115 control, 104 AS, and 145 BCID) met inclusion criteria. The time from blood culture collection to organism identification was shorter in the BCID group (17 h; P < 0.001) than in the control group (57 h) or the AS group (54 h). The BCID group had a shorter time to effective therapy (5 h; P < 0.001) than the control group (15 h) or AS group (13 h). The AS (57%) and BCID (52%) groups had higher rates of antimicrobial de-escalation than the control group (34%), with de-escalation occurring sooner in the BCID group (48 h; P = 0.034) than in the AS group (61 h) or the control group (63 h). No difference between the control group, AS group, and BCID group was seen with respect to mortality, 30-day readmission, intensive care unit length of stay (LOS), postculture LOS, or costs. In patients with BSI, ASP alone improved antimicrobial utilization. Addition of BCID to an established ASP shortened the time to effective therapy and further improved antimicrobial use compared to ASP alone, even in a setting of low antimicrobial resistance rates. PMID:27487951

  4. Genetically modified T cells targeting neovasculature efficiently destroy tumor blood vessels, shrink established solid tumors and increase nanoparticle delivery.

    PubMed

    Fu, Xinping; Rivera, Armando; Tao, Lihua; Zhang, Xiaoliu

    2013-11-15

    Converting T cells into tumor cell killers by grafting them with a chimeric antigen receptor (CAR) has shown promise as a cancer immunotherapeutic. However, the inability of these cells to actively migrate and extravasate into tumor parenchyma has limited their effectiveness in vivo. Here we report the construction of a CAR containing an echistatin as its targeting moiety (eCAR). As echistatin has high binding affinity to αvβ3 integrin that is highly expressed on the surface of endothelial cells of tumor neovasculature, T cells engrafted with eCAR (T-eCAR) can efficiently lyse human umbilical vein endothelial cells and tumor cells that express αvβ3 integrin when tested in vitro. Systemic administration of T-eCAR led to extensive bleeding in tumor tissues with no evidence of damage to blood vessels in normal tissues. Destruction of tumor blood vessels by T-eCAR significantly inhibited the growth of established bulky tumors. Moreover, when T-eCAR was codelivered with nanoparticles in a strategically designed temporal order, it dramatically increased nanoparticle deposition in tumor tissues, pointing to the possibility that it may be used together with nanocarriers to increase their capability to selectively deliver antineoplastic drugs to tumor tissues.

  5. Implication of MEK1 and MEK2 in the establishment of the blood-placenta barrier during placentogenesis in mouse.

    PubMed

    Charron, Jean; Bissonauth, Vickram; Nadeau, Valérie

    2012-07-01

    The ERK/MAPK signalling cascade is involved in many cellular functions. In mice, the targeted ablation of genes coding for members of this pathway is often associated with embryonic death due to the abnormal development of the placenta. The placenta is essential for nutritional and gaseous exchanges between maternal and embryonic circulations, as well as for the elimination of metabolic waste. These exchanges occur without direct contact between the two circulations. In mice, the blood-placenta barrier consists of a triple layer of trophoblast cells adjacent to endothelial cells from the embryo. In the ERK/MAPK cascade, MEK1 and MEK2 are dual-specificity kinases responsible for the activation of the ERK1 and ERK2 kinases. Inactivation of Mek1 causes placental malformations resulting from defective proliferation and differentiation of the labyrinthine trophoblast cells and leading to a severe delay in the development and the vascularization of the placenta, which explains the embryonic death. Although Mek2(-/-) mutants survive without any apparent phenotype, a large proportion of Mek1(+/-)Mek2(+/-) double heterozygous mutants die during gestation from placenta anomalies affecting the establishment of the blood-placenta barrier. Together, these data reveal how crucial is the role of the ERK/MAPK pathway during the formation of the placenta. Copyright © 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  6. WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line.

    PubMed

    Goodfellow, Sarah J; Rebello, Michelle R; Toska, Eneda; Zeef, Leo A H; Rudd, Sean G; Medler, Kathryn F; Roberts, Stefan G E

    2011-04-01

    The Wilms' tumour suppressor WT1 (Wilms' tumour 1) is a transcriptional regulator that plays a central role in organogenesis, and is mutated or aberrantly expressed in several childhood and adult malignancies. We previously identified BASP1 (brain acid-soluble protein 1) as a WT1 cofactor that suppresses the transcriptional activation function of WT1. In the present study we have analysed the dynamic between WT1 and BASP1 in the regulation of gene expression in myelogenous leukaemia K562 cells. Our findings reveal that BASP1 is a significant regulator of WT1 that is recruited to WT1-binding sites and suppresses WT1-mediated transcriptional activation at several WT1 target genes. We find that WT1 and BASP1 can divert the differentiation programme of K562 cells to a non-blood cell type following induction by the phorbol ester PMA. WT1 and BASP1 co-operate to induce the differentiation of K562 cells to a neuronal-like morphology that exhibits extensive arborization, and the expression of several genes involved in neurite outgrowth and synapse formation. Functional analysis revealed the relevance of the transcriptional reprogramming and morphological changes, in that the cells elicited a response to the neurotransmitter ATP. Taken together, the results of the present study reveal that WT1 and BASP1 can divert the lineage potential of an established blood cell line towards a cell with neuronal characteristics.

  7. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel L. Morrison; Sharon L. Elder

    2006-06-30

    The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL) established a national industry-driven Stripper Well Consortium (SWC) that is focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas producers, trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the ninth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) Develop and process subcontract awards for the nine projects selected at the 2006 Spring meeting; (2) Continue distribution of the DVD on ''Independent Oil: Rediscovering American's Forgotten Wells''; (3) Improving communications; (4) New member recruitment; (5) Identify SWC projects to be showcased for booth exhibition, preparing an exhibit, promoting and marketing for the 2006 Oklahoma Oil and Gas Trade Expo organized by the OK Marginal Well Commission, Oklahoma City, OK; and (6) Identify projects and draft agenda for the fall technical workshop in Pittsburgh, PA.

  8. Pig's blood in cigarette filters: how a single news release highlighted tobacco industry concealment of cigarette ingredients.

    PubMed

    Mackenzie, Ross; Chapman, Simon

    2011-03-01

    The tobacco industry is not obligated to disclose ingredients and additives used in manufactured tobacco production. This paper describes global reaction to a press release highlighting evidence that porcine haemoglobin ("pig's blood") was sometimes used in cigarette manufacturing while never being disclosed to smokers. The case study illustrates the power of press releases to ignite major interest in tobacco control issues.

  9. Blood

    MedlinePlus

    ... The liquid part, called plasma, is made of water, salts, and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells, and platelets. Red ...

  10. Pilot social feasibility study for the establishment of a public human umbilical cord blood stem cell bank in South Africa.

    PubMed

    Meissner-Roloff, Madelein; Young, Wendy; Rangaka, Isabella; Lombaard, Hennie; Dhai, Ames; Tsotsi, Norma; Pepper, Michael S

    2012-12-01

    There is a large unmet need in South Africa for bone marrow transplantation. Umbilical cord blood (UCB) is an important source of stem cells for the treatment of haematological and non-haematological diseases. Access to the two existing private umbilical cord blood stem cell banks (UCB SCBs) in South Africa is limited to individuals that can afford it, which further aggravates the ever increasing divide between families from different socio-economic classes. The problem is compounded by a severe global shortage of genetically compatible samples, representative of the South African demographics. Establishing a public human UCB SCB in South Africa would provide more South Africans with access to previously unavailable treatment in the form of affordable, genetically compatible stem cells for bone marrow transplantation. A public UCB SCB has many facets to consider, one of which is public preparedness and support for the bank. This was assessed in a social feasibility pilot study which is reported here. In addition to the findings of this social feasibility study, other important considerations for establishing a public human UCB SCB in SA include; (a) testing the samples for HIV and other infectious diseases (required for compliance with international regulatory standards); (b) flow cytometric analysis for enumeration of CD34+ UCB stem cells; (c) mapping of HLA genotypes/alleles; and (d) a study of the economic feasibility of this endeavour.The social feasibility study was conducted to gauge public preparedness and support for a public SCB through patient interviews and questionnaires. The process was dynamic due to its novel nature for interviewers and interviewees alike. Many obstacles were met and dealt with which lead to the compilation of results discussed here in the form of a pilot social feasibility study.In the South African context, we are faced with unique and rich challenges relating to cultural and religious differences that are further augmented by

  11. Establishment of normal values in adults for zinc protoporphyrin (ZPP) using hematofluorometer: correlation with normal blood lead values.

    PubMed

    Suga, R S; Fischinger, A J; Knoch, F W

    1981-09-01

    Zinc protoporphyrin (ZPP) values were analyzed with a hematofluorometer on 395 non-occupationally lead exposed subjects. Blood lead (B-Pb) determinations were concurrently carried out with an extraction procedure using flameless atomic absorption method. Applying Hoffman's Statistical Analysis with a logarithmic transformation, a normal range for ZPP (a mean of 23 microgram/dL) was established with 40 microgram ZPP/dL on the upper limit of the 95% probability range. A value of 54 microgram ZPP/dL has been found to be a suitable cutoff value above which one generally finds B-Pb values greater than 40 microgram/dL. For B-Pb values (less than 40 microgram/dL) and ZPP values in our normal range, there was essentially no correlation. However, for elevated values of both, a correlation coefficient of 0.87 was found for log ZZP versus B-Pb. ZPP values for males appeared to increase with increasing age.

  12. Lead concentration in blood samples of humans and animals near an industrial waste dump in Sao Paulo, Brazil.

    PubMed

    Kuno, R; Fernicola, N A; Roquetti-Humayta, M H; de Campos, A E; Filha, M T

    1999-08-01

    Blood lead was determined in 7 adults, 2 children, 1 bull, 11 cows, and 3 calves living on agricultural land near an industrial waste site. An unexposed human control group was composed of 2 adults and 2 children. Mean blood lead from the exposed group was 4.6 micrograms/dl for adults, 5.1 micrograms/dl for children, 1.3 micrograms/dl for the bull, 1.2 micrograms/dl for cows, and 1.8 micrograms/dl for calves. Unexposed adults had 4.1 micrograms/dl and children had 3.7 micrograms/dl lead blood. The blood lead content did not suggest a health hazard from lead for either humans or animals.

  13. Blood

    MedlinePlus

    ... that die or are lost from the body. White Blood Cells White blood cells (WBCs, and also ... of severe pain. previous continue Diseases of the White Blood Cells Neutropenia (pronounced: new-truh-PEE-nee- ...

  14. Establishment of a reference value for chromium in the blood for biological monitoring among occupational chromium workers.

    PubMed

    Li, Ping; Li, Yang; Zhang, Ji; Yu, Shan-Fa; Wang, Zhi-Liang; Jia, Guang

    2016-10-01

    The concentration of chromium in the blood (CrB) has been confirmed as a biomarker for occupational chromium exposure, but its biological exposure indices (BEIs) are still unclear, so we collected data from the years 2006 and 2008 (Shandong Province, China) to analyze the relationship between the concentration of chromium in the air (CrA) of the workplaces and CrB to establish a reference value of CrB for biological monitoring of occupational workers. The levels of the indicators for nasal injury, kidney (β2 microglobulin (β2-MG)), and genetic damages (8-hydroxy-deoxyguanosine (8-OHdG) and micronucleus (MN)) were measured in all subjects of the year 2011 (Henan Province, China) to verify the protective effect in this reference value of CrB. Compared with the control groups, the concentrations of CrA and CrB in chromium exposed groups were significantly higher (P < 0.05). Positive correlations were found between CrA and CrB in chromium exposed groups (r 2006 = 0.60, r 2008 = 0.35) in the years 2006 and 2008. According to the occupational exposure limitation of CrA (50 μg/m(3), China), the reference value of CrB was recommended to 20 μg/L. The levels of nasal injury, β2-MG, 8-OhdG, and MN were not significantly different between the low chromium exposed group (CrB ≤ 20 μg/L) and the control group, while the levels of β2-MG, 8-OHdG, and MN were statistically different in the high chromium exposed group than that in the control group. This research proved that only in occupational workers, CrB could be used as a biomarker to show chromium exposure in the environment. The recommended reference value of CrB was 20 μg/L. © The Author(s) 2015.

  15. [Significance and Clinical Application of the Establishment of RhD/C/c/E/e Blood Group Base in Chinese Nanyang City].

    PubMed

    Li, Hai-Yun; Cheng, Cong-Yuan

    2016-10-01

    To understand the regularity of Rh blood typing of valunteary blood donors in Chinese Nanyang city, and to estabbish a Rh DC/c/E/e antigen negative donor base so as to provide the help for clinical emergent blood transfusion to patients and ensure the safety of blood transfusion. The Rh D blood group of blood samples from 81462 voluntary blood donors in Chinese Nanyang city in 2014 was identified by serologic method; after first screening and confirmation, the RhE/e/C/c typing of Rh D negative samples was performed; the detailed infornation of donors was registered seriously by using unified creteria; the data base and base in kind of RhE/e/C/c types of valuntary donors were established by means of compater-mamayement system. 300 cases (0.37%) were RhD negative blood donors, and the Rh antigen was Ccdee and ccdee in 83%. The proportion of RhD negative donors accounts for 4% of Chinese Nanyang peoples, the RhE/e/C/c types of RhD negative donors are ccdee (50.67%)>Ccdee (33.00%)>ccdEe(5.67%)>CCdee (5.33%)>CcdEe(5.33%). The establisment of RhE/e/C/c subbase can show importent significance for clinical blood transfusion.

  16. Taking blood cultures from a newly established intravenous catheter in the emergency department does not increase the rate of contaminated blood cultures.

    PubMed

    Kelly, Anne-Maree; Klim, Sharon

    2013-10-01

    It has been suggested that blood cultures drawn from vascular catheters have a higher false positive rate than those drawn by venepuncture. In the face of institutionally imposed practice change prohibiting obtaining blood cultures from intravenous (i.v.) catheters in the ED, our aim of was to compare the rate of contaminated blood cultures between those taken from recently placed i.v. catheters and those taken by direct venepuncture. Prospective, non-randomised, observational study comparing the rate of contaminated blood cultures for specimens taken from recently placed (<1 h) i.v. catheters and direct venepuncture in adult ED patients. Outcome of interest was the rate of false positive cultures. Analysis was by comparison of proportions (χ(2) -test). Four hundred seventy-two blood culture sets were studied. There were 65 positive cultures, of which 49 (75%; 95% confidence interval [CI], 63-85%) were classified as true positive. The overall rate of contaminated blood cultures was 3.4% (95% CI, 2.0-5.6%). There was no difference in false positive rate between blood cultures taken via venepuncture and those taken from a recently placed i.v. cannula (P = 0.52; odds ratio, 0.9; 95% CI, 0.33-2.44). We found no difference in contaminated blood culture rate between recently placed i.v. catheters and direct venepuncture when infection control procedures were followed. © 2013 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  17. Role of dental pulp in identification of the deceased individual by establishing ABO blood grouping and Rhesus factor.

    PubMed

    Aswath, Nalini; Selvamuthukumar, S C; Karthika, B

    2012-01-01

    The study was conducted to emphasize the sensitivity and specificity of dental pulp in identifying the ABO Blood group, Rhesus factor and also to emphasize the role of dental pulp in forensic odontology to identify the deceased individual. The study was conducted on 60 patients. The samples obtained from finger-prick method from those 60 patients were considered as control and the samples obtained from the pulp were considered as case. The blood grouping, Rhesus typing for capillary blood drawn by finger prick was done by slide-agglutination method and the blood grouping, Rhesus typing for extracted dental pulp was done by absorption-elution method. Fifty seven teeth out of sixty showed positive results. Blood group elicited from capillary blood done by slide-agglutination method matched with that of the pulpal blood group elicited by absorption-elution method. Three showed negative results. As the teeth are the hardest, most stable biological material, resist adverse environmental conditions and the pulpal tissue inside the teeth is well protected, the blood group antigen from pulp remains stable for long. Thus, the high potential value of dental pulp tissue is highlighted in this study.

  18. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... establishment, and a copy will be sent to the reporting official if at another address. A permanent registration... establishment registration number and NDC Labeler Code. 607.35 Section 607.35 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND...

  19. Industry

    SciTech Connect

    Bernstein, Lenny; Roy, Joyashree; Delhotal, K. Casey; Harnisch, Jochen; Matsuhashi, Ryuji; Price, Lynn; Tanaka, Kanako; Worrell, Ernst; Yamba, Francis; Fengqi, Zhou; de la Rue du Can, Stephane; Gielen, Dolf; Joosen, Suzanne; Konar, Manaswita; Matysek, Anna; Miner, Reid; Okazaki, Teruo; Sanders, Johan; Sheinbaum Parado, Claudia

    2007-12-01

    This chapter addresses past, ongoing, and short (to 2010) and medium-term (to 2030) future actions that can be taken to mitigate GHG emissions from the manufacturing and process industries. Globally, and in most countries, CO{sub 2} accounts for more than 90% of CO{sub 2}-eq GHG emissions from the industrial sector (Price et al., 2006; US EPA, 2006b). These CO{sub 2} emissions arise from three sources: (1) the use of fossil fuels for energy, either directly by industry for heat and power generation or indirectly in the generation of purchased electricity and steam; (2) non-energy uses of fossil fuels in chemical processing and metal smelting; and (3) non-fossil fuel sources, for example cement and lime manufacture. Industrial processes also emit other GHGs, e.g.: (1) Nitrous oxide (N{sub 2}O) is emitted as a byproduct of adipic acid, nitric acid and caprolactam production; (2) HFC-23 is emitted as a byproduct of HCFC-22 production, a refrigerant, and also used in fluoroplastics manufacture; (3) Perfluorocarbons (PFCs) are emitted as byproducts of aluminium smelting and in semiconductor manufacture; (4) Sulphur hexafluoride (SF{sub 6}) is emitted in the manufacture, use and, decommissioning of gas insulated electrical switchgear, during the production of flat screen panels and semiconductors, from magnesium die casting and other industrial applications; (5) Methane (CH{sub 4}) is emitted as a byproduct of some chemical processes; and (6) CH{sub 4} and N{sub 2}O can be emitted by food industry waste streams. Many GHG emission mitigation options have been developed for the industrial sector. They fall into three categories: operating procedures, sector-wide technologies and process-specific technologies. A sampling of these options is discussed in Sections 7.2-7.4. The short- and medium-term potential for and cost of all classes of options are discussed in Section 7.5, barriers to the application of these options are addressed in Section 7.6 and the implication of

  20. 76 FR 22903 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing That a Tobacco...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... Request AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug... February 15, 2007'' to the Center for Tobacco Products, Food and Drug Administration, 9200 Corporate...

  1. The effects of occupational noise on blood pressure and heart rate of workers in an automotive parts industry.

    PubMed

    Kalantary, Saba; Dehghani, Ali; Yekaninejad, Mir Saeed; Omidi, Leila; Rahimzadeh, Mitra

    2015-07-01

    One of the most important impacts of industrial noise is physiological and psychological effects. The increases in workers' blood pressure and heart rate were detected during and after exposure to high levels of noise. The objectives of this research were to determine whether the noise exposures have any effects on blood pressure and heart rate of workers in the automotive parts industry. This case study was done in 2011 at different units of an automotive parts manufacturing in Tehran. Sound pressure level was measured at different units of the factory with a calibrated instrument. Demographic features of workers were gathered with an appropriate questionnaire. Heart rate and blood pressure were measured twice in a day in the start time of work day (before exposure to noise) and middle shift hours (during exposure to noise) in the occupational physician office. For analyzing data, chi-square, independent sample t-test, paired t-test, and analysis of covariance (ANCOVA) were used. P < 0.050 was considered statistically significant. The average age of workers in the case and control groups was 35.71 ± 8.10 and 33.40 ± 10.41 years, respectively. There was no difference between the average age of case and control groups (P = 0.436). The results of ANCOVA revealed the significant differences between the mean changes of heart rate F (1, 37) = 26.68, P < 0.001, systolic blood pressure F (1, 37) = 21.70, P < 0.001, and diastolic blood pressure F (1, 37) = 26.20, P < 0.001 of workers in the case and control groups. Exposure to industrial noise may increase the heart rate of workers. Although rises in heart rate, systolic, and diastolic blood pressure of workers in the case group were observed after exposure to noise, the values of heart rate, systolic, and diastolic blood pressure were in the normal range. Further experimental investigations are needed to determine the relationships between these variables.

  2. The effects of occupational noise on blood pressure and heart rate of workers in an automotive parts industry

    PubMed Central

    Kalantary, Saba; Dehghani, Ali; Yekaninejad, Mir Saeed; Omidi, Leila; Rahimzadeh, Mitra

    2015-01-01

    BACKGROUND One of the most important impacts of industrial noise is physiological and psychological effects. The increases in workers’ blood pressure and heart rate were detected during and after exposure to high levels of noise. The objectives of this research were to determine whether the noise exposures have any effects on blood pressure and heart rate of workers in the automotive parts industry. METHODS This case study was done in 2011 at different units of an automotive parts manufacturing in Tehran. Sound pressure level was measured at different units of the factory with a calibrated instrument. Demographic features of workers were gathered with an appropriate questionnaire. Heart rate and blood pressure were measured twice in a day in the start time of work day (before exposure to noise) and middle shift hours (during exposure to noise) in the occupational physician office. For analyzing data, chi-square, independent sample t-test, paired t-test, and analysis of covariance (ANCOVA) were used. P < 0.050 was considered statistically significant. RESULTS The average age of workers in the case and control groups was 35.71 ± 8.10 and 33.40 ± 10.41 years, respectively. There was no difference between the average age of case and control groups (P = 0.436). The results of ANCOVA revealed the significant differences between the mean changes of heart rate F (1, 37) = 26.68, P < 0.001, systolic blood pressure F (1, 37) = 21.70, P < 0.001, and diastolic blood pressure F (1, 37) = 26.20, P < 0.001 of workers in the case and control groups. CONCLUSION Exposure to industrial noise may increase the heart rate of workers. Although rises in heart rate, systolic, and diastolic blood pressure of workers in the case group were observed after exposure to noise, the values of heart rate, systolic, and diastolic blood pressure were in the normal range. Further experimental investigations are needed to determine the relationships between these variables. PMID:26478728

  3. Efficient and reliable establishment of lymphoblastoid cell lines by Epstein-Barr virus transformation from a limited amount of peripheral blood

    PubMed Central

    Omi, Natsue; Tokuda, Yuichi; Ikeda, Yoko; Ueno, Morio; Mori, Kazuhiko; Sotozono, Chie; Kinoshita, Shigeru; Nakano, Masakazu; Tashiro, Kei

    2017-01-01

    Lymphoblastoid cell lines (LCLs) transformed by Epstein-Barr virus (EBV) serve as an unlimited resource of human genomic DNA. The protocol that is widely used to establish LCLs involves peripheral blood mononuclear cell isolation by density gradient centrifugation, however, that method requires as much as 5 ml of peripheral blood. In this study, in order to provide a more simple and efficient method for the generation of LCLs, we developed a new protocol using hemolytic reaction to enrich white blood cells for EBV transformation and found that the hemolytic protocol successfully generated LCLs from a small volume (i.e., 0.1 ml) of peripheral blood. To assess the quality of genomic DNA extracted from LCLs established by the hemolytic protocol (LCL-hemolytic), we performed single nucleotide polymorphism (SNP) microarray genotyping using the GeneChip® 100 K Array Set (Affymetrix, Inc.). The concordances of the SNP genotyping resulting from genomic DNA from LCL-hemolytic (99.92%) were found to be as good as the technical replicate (99.90%), and Kappa statistics results confirmed the reliability. The findings of this study reveal that the hemolytic protocol is a simple and reliable method for the generation of LCLs, even from a small volume of peripheral blood. PMID:28272413

  4. Benzene in blood and phenol in urine in monitoring benzene exposure in industry

    SciTech Connect

    Braier, L.; Levy, A.; Dror, K.; Pardo, A.

    1981-01-01

    Determinations of benzene concentration in blood and of phenol in urine were made by head-space gas chromatography techniques on samples taken near the end of the work day from two groups of workers potentially exposed to low levels of benzene in the work-place atmosphere. Preliminary results suggest that benzene in blood is more reliable than phenol tests for assessing both exposure and uptake of benzene. Normal values of phenol in urine (10 mg/liter or less) were found in nearly all those cases in which benzene was detected in the blood.

  5. 75 FR 73107 - Guidance for Industry and Food and Drug Administration Staff; Blood Lancet Labeling; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ..., 10903 New Hampshire Ave., Bldg. 66, Rm. 4613, Silver Spring, MD 20993-0002. Send one self-addressed... validated for efficacy or followed in their entirety. FDA recommends that all blood lancet devices...

  6. Distribution of blood derivatives by registered blood establishments that qualify as health care entities; Prescription Drug Marketing Act of 1987; Prescription Drug Amendments of 1992; delay of applicability date. Final rule; delay of applicability date.

    PubMed

    2006-11-13

    The Food and Drug Administration (FDA) is further delaying, until December 1, 2008, the applicability date of a certain requirement of a final rule published in the Federal Register of December 3, 1999 (64 FR 67720) (the final rule). The final rule implements the Prescription Drug Marketing Act of 1987 (PDMA), as modified by the Prescription Drug Amendments of 1992 (PDA), and the Food and Drug Administration Modernization Act of 1997 (the Modernization Act). The provisions of the final rule became effective on December 4, 2000, except for certain provisions whose effective or applicability dates were delayed in five subsequent Federal Register notices, until December 1, 2006. The provision with the delayed applicability date would prohibit wholesale distribution of blood derivatives by registered blood establishments that meet the definition of a "health care entity." In the Federal Register of February 1, 2006 (71 FR 5200), FDA published a proposed rule specific to the distribution of blood derivatives by registered blood establishments that qualify as health care entities (the proposed rule). The proposed rule would amend certain limited provisions of the final rule to allow certain registered blood establishments that qualify as health care entities to distribute blood derivatives. In response to the proposed rule, FDA received substantive comments. As explained in the SUPPLEMENTARY INFORMATION section of this document, further delaying the applicability of Sec. 203.3(q) (21 CFR 203.3(q)) to the wholesale distribution of blood derivatives by health care entities is necessary to give the agency additional time to address comments on the proposed rule, consider whether regulatory changes are appropriate, and, if so, to initiate such changes.

  7. Error management in blood establishments: results of eight years of experience (2003–2010) at the Croatian Institute of Transfusion Medicine

    PubMed Central

    Vuk, Tomislav; Barišić, Marijan; Očić, Tihomir; Mihaljević, Ivanka; Šarlija, Dorotea; Jukić, Irena

    2012-01-01

    Background. Continuous and efficient error management, including procedures from error detection to their resolution and prevention, is an important part of quality management in blood establishments. At the Croatian Institute of Transfusion Medicine (CITM), error management has been systematically performed since 2003. Materials and methods. Data derived from error management at the CITM during an 8-year period (2003–2010) formed the basis of this study. Throughout the study period, errors were reported to the Department of Quality Assurance. In addition to surveys and the necessary corrective activities, errors were analysed and classified according to the Medical Event Reporting System for Transfusion Medicine (MERS-TM). Results. During the study period, a total of 2,068 errors were recorded, including 1,778 (86.0%) in blood bank activities and 290 (14.0%) in blood transfusion services. As many as 1,744 (84.3%) errors were detected before issue of the product or service. Among the 324 errors identified upon release from the CITM, 163 (50.3%) errors were detected by customers and reported as complaints. In only five cases was an error detected after blood product transfusion however without any harmful consequences for the patients. All errors were, therefore, evaluated as “near miss” and “no harm” events. Fifty-two (2.5%) errors were evaluated as high-risk events. With regards to blood bank activities, the highest proportion of errors occurred in the processes of labelling (27.1%) and blood collection (23.7%). With regards to blood transfusion services, errors related to blood product issuing prevailed (24.5%). Conclusion. This study shows that comprehensive management of errors, including near miss errors, can generate data on the functioning of transfusion services, which is a precondition for implementation of efficient corrective and preventive actions that will ensure further improvement of the quality and safety of transfusion treatment. PMID

  8. A Study to Develop a Methodology Determining the Feasibility of Establishing a Blood Collection Program in an Army Healthcare Facility

    DTIC Science & Technology

    1985-05-01

    to detect the antibody to the AIDS virus. The Public Health Service mandated HTLV -III testing in all federal facilities. 28 Other risk factors are...EVALUATION OF ALTERNATIVES The preceeding discussion gives a cognitive appreciation for many of the factors which impact on assessing the feasibility of...Military Implementation of Public Helath Service Provisional Recommendations Concerning Testing Blood and Plasma for Antibodies to HTLV -III, 13 March

  9. [Persistent thrombocytopenia in a child: morphological examination of blood platelets established the diagnosis of Wiskott-Aldrich syndrome].

    PubMed

    Latger-Cannard, V; Lacroix, F; Devignes, J; Salignac, S; Bensoussan, D; Salmon, A; Mansuy, L; Bordigoni, P; Lecompte, T

    2008-01-01

    Thrombocytopenia frequently occurs in laboratory practice. The present work illustrates, through the presentation of a case report of Wiskott-Aldrich syndrome, the difficulties encountered to identify and characterize thrombocytopenia. The clinicobiological validation of a low platelet count involves both the biologist, who must assume the validation of numeration while mentioning the morphological characteristics of the platelets and other blood cells, as well as the physician who has to interpret these data according to the clinical context.

  10. Moving East: how the transnational tobacco industry gained entry to the emerging markets of the former Soviet Union-part I: establishing cigarette imports.

    PubMed

    Gilmore, A B; McKee, M

    2004-06-01

    To identify British American Tobacco's (BAT) reasons for targeting the former Soviet Union following its collapse in 1991 and the initial strategies BAT used to enter the region. Analysis of tobacco industry documents held at the Guildford BAT archive. Desire to expand to new markets was based in part on the decline in old markets. The large population, proximity to China, scope to expand sales to women and, in Central Asia, a young population with high growth rates made the former Soviet Union particularly attractive. High consumption rates and unfilled demand caused by previous shortages offered potential for rapid returns on investment. A series of steps were taken to penetrate the markets with the initial focus on establishing imports. The documents suggest that BAT encouraged the use of aid money and barter trade to fund imports and directed the smuggling of cigarettes which graduated from an opportunistic strategy to a highly organised operation. In establishing a market presence, promotion of BAT's brands and corporate image were paramount, and used synonymously to promote both the cigarettes and the company. The tobacco industry targeted young people and women. It used the allure of western products to promote its brands and brand stretching and corporate imagery to pre-empt future marketing restrictions. BAT used the chaotic conditions in the immediate post-transition period in the former Soviet Union to exploit legislative loopholes and ensure illegal cigarette imports. Governments of countries targeted by the tobacco industry need to be aware of industry tactics and develop adequate tobacco control policies in order to prevent the exploitation of vulnerable populations. Marketing restrictions that focus on advertising without restricting the use of brand or company promotions will have a limited impact.

  11. Moving East: how the transnational tobacco industry gained entry to the emerging markets of the former Soviet Union—part I: establishing cigarette imports

    PubMed Central

    Gilmore, A; McKee, M

    2004-01-01

    Objectives: To identify British American Tobacco's (BAT) reasons for targeting the former Soviet Union following its collapse in 1991 and the initial strategies BAT used to enter the region. Design: Analysis of tobacco industry documents held at the Guildford BAT archive. Results: Desire to expand to new markets was based in part on the decline in old markets. The large population, proximity to China, scope to expand sales to women and, in Central Asia, a young population with high growth rates made the former Soviet Union particularly attractive. High consumption rates and unfilled demand caused by previous shortages offered potential for rapid returns on investment. A series of steps were taken to penetrate the markets with the initial focus on establishing imports. The documents suggest that BAT encouraged the use of aid money and barter trade to fund imports and directed the smuggling of cigarettes which graduated from an opportunistic strategy to a highly organised operation. In establishing a market presence, promotion of BAT's brands and corporate image were paramount, and used synonymously to promote both the cigarettes and the company. The tobacco industry targeted young people and women. It used the allure of western products to promote its brands and brand stretching and corporate imagery to pre-empt future marketing restrictions. Conclusions: BAT used the chaotic conditions in the immediate post-transition period in the former Soviet Union to exploit legislative loopholes and ensure illegal cigarette imports. Governments of countries targeted by the tobacco industry need to be aware of industry tactics and develop adequate tobacco control policies in order to prevent the exploitation of vulnerable populations. Marketing restrictions that focus on advertising without restricting the use of brand or company promotions will have a limited impact. PMID:15175531

  12. Telomere Length Is Not Related to Established Cardiovascular Risk Factors but Does Correlate with Red and White Blood Cell Counts in a German Blood Donor Population

    PubMed Central

    Kelsch, Reinhard; Jäger, Kathrin; Brüggmann, Nina; van der Harst, Pim; Walter, Michael

    2015-01-01

    Telomere length (TL) is considered a marker of biological aging and has been associated with the presence of various coronary risk factors in patients. Much less is known about the relationships between TL and classic coronary risk factors in other populations. We measured TL in peripheral blood leukocytes of 343 middle-aged blood donors (mean age 40.2 ± 12.4 years; 201 men, 142 women) using quantitative polymerase chain reaction. Median TL was 0.86 (range: 0.48–1.85) relative TL units. In linear regression analyses with natural log-transformed T to S ratio as the dependent variable, there was a significant association with age (per year: beta = -0.007, p<0.001) and sex (males vs. females: beta = 0.075, p = 0.007) with longer telomeres in men. After adjusting for these two variables, we observed no association of TL with classic coronary risk factors including cholesterol (p = 0.36), triglyceride (p = 0.09), HDL-cholesterol (p = 0.26), LDL-cholesterol (p = 0.36), smoking (p = 0.97), and personal (p = 0.46) or family history (p = 0.63) of cardiovascular disease. However, we did find a significant positive association with white (p = 0.011) and red blood cell count (p = 0.031), hemoglobin (p = 0.014) and hematocrit (p = 0.013); we also found a borderline positive association with thrombocytes (p = 0.074). Positive associations remained significant for hemoglobin (p = 0.017), hematocrit (p = 0.023), and leukocytes (p = 0.009) in a subgroup with no reported vascular disease; associations were of borderline significance for erythrocytes (p = 0.053) and thrombocytes (p = 0.088) in this subgroup. The data do not support the concept that classic coronary risk factors contribute to telomere attrition in a blood donor population. However, telomere attrition may be a marker for reduced proliferation reserve in hematopoietic progenitor cells. PMID:26445269

  13. Establishing baseline levels of trace elements in blood and skin of bottlenose dolphins in Sarasota Bay, Florida: implications for non-invasive monitoring.

    PubMed

    Bryan, Colleen E; Christopher, Steven J; Balmer, Brian C; Wells, Randall S

    2007-12-15

    Several major unusual mortality events occurring in recent years have increased the level of concern for the health of bottlenose dolphin populations along the United States Atlantic and Gulf of Mexico coasts. Trace element concentrations were examined in a population of free-ranging dolphins in Sarasota Bay, Florida, in order to develop a benchmark for future comparisons within and between populations. Whole blood (n=51) and skin (n=40) samples were collected through capture and release health assessment events during 2002-2004. Samples were analyzed for Al, V, Cr, Mn, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, and Pb by inductively coupled plasma mass spectrometry (ICPMS) and Hg via atomic fluorescence spectrometry (AFS). Trace element concentrations (wet mass) in skin were 2 to 45 times greater than blood, except Cu was approximately 1.5 times higher in blood. Statistically strong correlations (p<0.05) were found for V, As, Se, Rb, Sr, and Hg between blood and skin demonstrating that these tissues can be used as effective non-lethal monitoring tools. The strongest correlation was established for Hg (r=0.9689) and concentrations in both blood and skin were above the threshold at which detrimental effects are observed in other vertebrate species. Female dolphins had significantly greater Hg concentrations in blood and skin and Pb concentrations in skin, relative to males. Calves exhibited significantly lower V, As, and Hg concentrations in blood and V and Hg concentrations in skin, relative to other age classes. Rubidium and Cu concentrations in skin were greatest in subadults and calves, respectively. In blood, V, Zn, and As concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Rb and Sr concentrations. In skin, Cu and Zn concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Mn, Rb, Cd, and Pb concentrations. The baseline concentrations and trends

  14. Extensive Ex Vivo Expansion of Functional Human Erythroid Precursors Established From Umbilical Cord Blood Cells by Defined Factors

    PubMed Central

    Huang, Xiaosong; Shah, Siddharth; Wang, Jing; Ye, Zhaohui; Dowey, Sarah N; Tsang, Kit Man; Mendelsohn, Laurel G; Kato, Gregory J; Kickler, Thomas S; Cheng, Linzhao

    2014-01-01

    There is a constant shortage of red blood cells (RBCs) from sufficiently matched donors for patients who need chronic transfusion. Ex vivo expansion and maturation of human erythroid precursors (erythroblasts) from the patients or optimally matched donors could represent a potential solution. Proliferating erythroblasts can be expanded from umbilical cord blood mononuclear cells (CB MNCs) ex vivo for 106–107-fold (in ~50 days) before proliferation arrest and reaching sufficient number for broad application. Here, we report that ectopic expression of three genetic factors (Sox2, c-Myc, and an shRNA against TP53 gene) associated with iPSC derivation enables CB-derived erythroblasts to undergo extended expansion (~1068-fold in ~12 months) in a serum-free culture condition without change of cell identity or function. These expanding erythroblasts maintain immature erythroblast phenotypes and morphology, a normal diploid karyotype and dependence on a specific combination of growth factors for proliferation throughout expansion period. When being switched to a terminal differentiation condition, these immortalized erythroblasts gradually exit cell cycle, decrease cell size, accumulate hemoglobin, condense nuclei and eventually give rise to enucleated hemoglobin-containing erythrocytes that can bind and release oxygen. Our result may ultimately lead to an alternative approach to generate unlimited numbers of RBCs for personalized transfusion medicine. PMID:24002691

  15. Management of complaints in blood establishments: thirteen years of experience at the Croatian Institute of Transfusion Medicine.

    PubMed

    Vuk, Tomislav; Barišić, Marijan; Očić, Tihomir; Đogić, Vesna; Bingulac-Popović, Jasna; Sarlija, Dorotea; Balija, Melita; Jukić, Irena

    2012-07-01

    The aim of the study is to present the results and experience in the management of complaints in a transfusion service in order to draw attention to the importance of this segment of quality management and to stimulate publication of other studies on the topic. This study is based on data from the Croatian Institute of Transfusion Medicine obtained by analysis of complaints recorded during a 13-year period (1998-2010). The distribution of the types and frequencies of complaints is presented, along with the level of their justifiability and criticality. The dynamics of the complaints is analysed overall and within particular categories. In addition, corrective actions and other factors that may have influenced the trends observed are discussed. During the study period, 817 complaints were received, most of which (40.9%) referred to the positive direct antiglobulin test in red cell concentrates, followed by blood product issuing and distribution (12.9%) and blood product quality (9.4%). Of the 817 complaints, 177 (21.7%) were assessed as serious and 645 (78.9%) as justified based on the testing performed. Data collected by systematic recording and analysis of complaints provide a basis for problem identification, implementation of corrective and preventive actions, and improvement of product and service quality, and, thereby, customer satisfaction.

  16. Management of complaints in blood establishments: thirteen years of experience at the Croatian Institute of Transfusion Medicine

    PubMed Central

    Vuk, Tomislav; Barišić, Marijan; Očić, Tihomir; Đogić, Vesna; Bingulac-Popović, Jasna; Šarlija, Dorotea; Balija, Melita; Jukić, Irena

    2012-01-01

    Background. The aim of the study is to present the results and experience in the management of complaints in a transfusion service in order to draw attention to the importance of this segment of quality management and to stimulate publication of other studies on the topic. Materials and methods. This study is based on data from the Croatian Institute of Transfusion Medicine obtained by analysis of complaints recorded during a 13-year period (1998–2010). The distribution of the types and frequencies of complaints is presented, along with the level of their justifiability and criticality. The dynamics of the complaints is analysed overall and within particular categories. In addition, corrective actions and other factors that may have influenced the trends observed are discussed. Results. During the study period, 817 complaints were received, most of which (40.9%) referred to the positive direct antiglobulin test in red cell concentrates, followed by blood product issuing and distribution (12.9%) and blood product quality (9.4%). Of the 817 complaints, 177 (21.7%) were assessed as serious and 645 (78.9%) as justified based on the testing performed. Conclusion. Data collected by systematic recording and analysis of complaints provide a basis for problem identification, implementation of corrective and preventive actions, and improvement of product and service quality, and, thereby, customer satisfaction. PMID:22507865

  17. Intrabone Transplant of Cord Blood Stem Cells Establishes a Local Engraftment Store: A Functional PET/FDG Study

    PubMed Central

    Marini, Cecilia; Podestà, Marina; Massollo, Michela; Capitanio, Selene; Fiz, Francesco; Morbelli, Silvia; Brignone, Massimo; Bacigalupo, Andrea; Piana, Michele; Frassoni, Francesco; Sambuceti, Gianmario

    2012-01-01

    Background. Despite advancements in comprehension of molecular mechanisms governing bone marrow (BM) homing of hematopoietic stem cells, cord blood transplant (CBT) suffers from a slow rate of hematopoietic recovery. Intrabone (IB) injection has been proposed as a method able to improve speed of BM engraftment with respect to conventional IV protocols. However, the mechanisms underlying this benefit are largely unknown. Aim. To verify whether IB-CBT determines a local engraftment able to predict the reconstitution of recipient hematopoiesis. Design and Methods. Twenty-one patients with hematologic malignancies received IB injection into both iliac crests of 3.2 ± 0.68 ∗ 107/kg cord blood cells. One month following IB-CBT, PET-CT imaging was performed. Maximal standardized uptake values (SUVs) were assessed in BM of both iliac crests and in all lumbar vertebrae. Results. Maximal SUV within iliac crests was higher than in lumbar vertebrae (4.1 ± 1.7 versus 3.2 ± 0.7, resp., P = 0.01). However, metabolic activity in these two different BM districts was significantly correlated (r = 0.7, P < 0.001). Moreover, FDG uptake values within the injection site closely predicted platelet recovery 100 days after IB-CBT (r = 0.72, P < 0.01). Conclusions. The metabolic activity of injected BM predicts the subsequent rate of hematopoietic recovery after IB-CBT, suggesting a pivotal role of the local engraftment in the reconstitution of recipient hematopoiesis. PMID:23093864

  18. Blood

    MedlinePlus

    ... spans vary from a few days to months. New cells are constantly being formed in the bone marrow. ... the bloodstream and are constantly being replaced by new cells. Blood also contains important proteins called clotting factors , ...

  19. Industrially scaled pulsed laser deposition based coating techniques for the realization of hemocompatible surfaces for blood contact applications

    NASA Astrophysics Data System (ADS)

    Lackner, Juergen M.; Waldhauser, Wolfgang; Major, Roman; Major, Boguslaw; Czarnowska, Elzbieta; Bruckert, Franz

    2008-05-01

    Non-thrombogenic blood contacting surfaces and appropriate blood flow characteristics are essential for clinical application. State-of-the-art coatings are based on heparin and struggle with the problem of bleeding. Thus, there is increasing demand for developing new coating materials for improved human body acceptance. Materials deposited by vacuum coating techniques would be an excellent alternative if the coating temperatures can be kept low due to the applied substrate materials of low temperature resistance (mostly polymers). Under these circumstances, adequate film structure and high adhesion can be reached by the Pulsed Laser Deposition at room temperature (RT-PLD), which was developed to an industrial-scaled process at Laser Center Leoben. This process was applied to deposit Ti, TiN, TiCN and diamond-like carbon (DLC) on polyurethane, titanium and silicon substrates to study the biological interactions to blood cells and the kinetic mechanism of eukaryote cell attachment. Besides high biological acceptance, distinct differences for the critical delamination shear stress were found for the coatings, indicating higher adhesion at higher carbon contents.

  20. Environmental and socioeconomic factors contributing to elevated blood lead levels in children from an industrial area of Upper Silesia.

    PubMed

    Pelc, Wojciech; Pawlas, Natalia; Dobrakowski, Michał; Kasperczyk, Sławomir

    2016-10-01

    The present study concentrated on a cross-sectional analysis of recent exposure to lead (Pb) and the socioeconomic factors behind increased Pb exposure in Polish children. Lead is one of the most widespread toxic heavy metals in the industrial region of Upper Silesia (Poland). Elevated blood Pb levels in children continue to be a matter of serious concern. The present study involved 4882 children from the Upper Silesia region, aged from 3 yr to 18 yr, over the calendar years 1999 to 2013. The concentration of Pb in blood was determined in each child. The children's parents were asked to answer survey questions about the child's environmental exposure to Pb as well as the socioeconomic condition of the family. Factors that correspond with increased exposure to Pb included: lower level of education of parents, unemployment, parents' occupational Pb exposure, poor socioeconomic status of the family, smoking at home, living on the ground floor of buildings, consumption of locally grown vegetables and fruits, longer outdoor playing periods in a polluted environment, and male gender. Environmental exposure to Pb is the most important factor behind chronic poisoning of children in Upper Silesia. The most important socioeconomic factor associated with concentrations of Pb in children's blood is a lower level of education of a child's mother and father. Environ Toxicol Chem 2016;35:2597-2603. © 2016 SETAC. © 2016 SETAC.

  1. Establishment of a mammalian cell line suitable for industrial production of recombinant protein using mutations induced by high-energy beam radiation.

    PubMed

    Chida, Yasuhito; Takagi, Keiichi; Terada, Satoshi

    2013-12-01

    Mammalian cells are extensively used for production of biopharmaceuticals. Most cells used in industry have infinite proliferative capacity, which provides a high number of cells and corresponding productivity. However, infinite cells will continue to multiply even after cell density reaches sufficient levels. This excess proliferation aggravates the culture environment and induces low productivity. Therefore, after cell density reaches sufficient levels, downregulation of proliferation would prevent such aggravation and extend the culture period and improve productivity. To realize such suitable proliferation, we aimed to establish a novel cell line whose proliferation was spontaneously downregulated after reaching a sufficient population level. Mutagenesis using high-energy beam irradiation was used. CHO-DP12 cells were irradiated with 2.5 Gy X-rays and screened with hydroxyurea and 5-fluorouracil to eliminate any cells multiplying after confluence and to concentrate desired mutants. One clone was established and named CHO-M1. Cell cycle analysis indicated that CHO-M1 cells had a similar cell cycle profile in the exponential growth phase, but cells rapidly accumulated in G1 phase just before confluence and did not progress through the cell cycle. This suggested that until confluence, proliferation of CHO-M1 was similar to parental CHO, but after confluence, it was inhibited and under G1 arrest. The specific antibody production rate of CHO-M1 was kept high, even after confluence, while that of parental CHO was drastically decreased in stationary phase. These results suggest that the desired cell line was successfully established and that high-energy beam irradiation could be an efficient mutagenic technique for breeding industrial cells.

  2. The re-establishment of the normal blood lactate response to exercise in humans after prolonged acclimatization to altitude

    PubMed Central

    van Hall, G; Calbet, J A L; Søndergaard, H; Saltin, B

    2001-01-01

    One to five weeks of chronic exposure to hypoxia has been shown to reduce peak blood lactate concentration compared to acute exposure to hypoxia during exercise, the high altitude ‘lactate paradox’. However, we hypothesize that a sufficiently long exposure to hypoxia would result in a blood lactate and net lactate release from the active leg to an extent similar to that observed in acute hypoxia, independent of work intensity. Six Danish lowlanders (25–26 years) were studied during graded incremental bicycle exercise under four conditions: at sea level breathing either ambient air (0 m normoxia) or a low-oxygen gas mixture (10 % O2 in N2, 0 m acute hypoxia) and after 9 weeks of acclimatization to 5260 m breathing either ambient air (5260 m chronic hypoxia) or a normoxic gas mixture (47 % O2 in N2, 5260 m acute normoxia). In addition, one-leg knee-extensor exercise was performed during 5260 m chronic hypoxia and 5260 m acute normoxia. During incremental bicycle exercise, the arterial lactate concentrations were similar at sub-maximal work at 0 m acute hypoxia and 5260 m chronic hypoxia but higher compared to both 0 m normoxia and 5260 m acute normoxia. However, peak lactate concentration was similar under all conditions (10.0 ± 1.3, 10.7 ± 2.0, 10.9 ± 2.3 and 11.0 ± 1.0 mmol l−1) at 0 m normoxia, 0 m acute hypoxia, 5260 m chronic hypoxia and 5260 m acute normoxia, respectively. Despite a similar lactate concentration at sub-maximal and maximal workload, the net lactate release from the leg was lower during 0 m acute hypoxia (peak 8.4 ± 1.6 mmol min−1) than at 5260 m chronic hypoxia (peak 12.8 ± 2.2 mmol min−1). The same was observed for 0 m normoxia (peak 8.9 ± 2.0 mmol min−1) compared to 5260 m acute normoxia (peak 12.6 ± 3.6 mmol min−1). Exercise after acclimatization with a small muscle mass (one-leg knee-extensor) elicited similar lactate concentrations (peak 4.4 ± 0.2 vs. 3.9 ± 0.3 mmol l−1) and net lactate release (peak 16.4 ± 1

  3. Relationships between blood lead concentration and aminolevulinic acid dehydratase in alcoholics and workers industrially exposed to lead

    SciTech Connect

    Bortoli, A.; Fazzin, G.; Marin, V.; Trabuio, G.; Zotti, S.

    1986-07-01

    Blood lead concentration (Pb-B), aminolevulinic acid dehydratase (ALAD), and gamma-GT were measured in 265 workers industrially exposed to lead and in 184 patients with liver disease resulting from alcohol consumption. The first group was divided according to alcohol use, i.e., nondrinkers, moderate drinkers, and heavy drinkers. The second group was divided according to the following criteria: hepatopatic without cirrhosis, hepatopatic with compensated cirrhosis, and hepatopatic with decompensated cirrhosis. Heavy drinkers who were industrially exposed had the highest Pb-B (40.4 +/- 14.6 micrograms/dl) and the lowest ALAD (22.2 +/- 9.1 U/L). The correlations between Pb-B and ALAD show no significant change with the increase of Pb-B. In the alcoholic group, 76 patients with alcoholic liver disease without cirrhosis had the highest Pb-B (40.3-9.1 micrograms/dl) and ALAD the lowest (18.6 +/- 7.7 U/L). The negative correlation between Pb-B and log ALAD disappeared completely in individuals with Pb-B that exceeded 50 micrograms/dl, independent from the seriousness of illness.

  4. Establishment of Age- and Gender-Specific Reference Ranges for 36 Routine and 57 Cell Population Data Items in a New Automated Blood Cell Analyzer, Sysmex XN-2000.

    PubMed

    Park, Sang Hyuk; Park, Chan Jeoung; Lee, Bo Ra; Kim, Mi Jeong; Han, Min Young; Cho, Young Uk; Jang, Seongsoo

    2016-05-01

    We established age- and gender-specific reference ranges for the 36 routine complete blood cell (CBC) and 57 cell population data (CPD) items in the Sysmex XN-2000 (Sysmex, Japan). In total, 280 peripheral blood samples were obtained from an equal number of healthy adults. Values for 36 routine items and 57 CPD items were obtained for each sample, and the results were categorized into six subgroups (N>39 in each subgroup) according to patient age (20-40, 41-60, and >60 yr) and gender (male and female), and compared with respect to age and gender differences. The majority of data items (22 of 36 routine CBC items and 44 of 57 CPD items) exhibited significant differences (P≤0.05) in their results with respect to age or gender, and several red cell-, lymphocyte-, and platelet-related data tended to decrease in women or older adults. These results provide a basis for establishing age- and gender-specific reference ranges for routine and CPD items in Sysmex XN-2000. Furthermore, these reference ranges could be used to determine clinical significance for new items of Sysmex XN-2000 in further studies.

  5. Establishment of Age- and Gender-Specific Reference Ranges for 36 Routine and 57 Cell Population Data Items in a New Automated Blood Cell Analyzer, Sysmex XN-2000

    PubMed Central

    Park, Sang Hyuk; Lee, Bo-Ra; Kim, Mi-Jeong; Han, Min-Young; Cho, Young-Uk; Jang, Seongsoo

    2016-01-01

    We established age- and gender-specific reference ranges for the 36 routine complete blood cell (CBC) and 57 cell population data (CPD) items in the Sysmex XN-2000 (Sysmex, Japan). In total, 280 peripheral blood samples were obtained from an equal number of healthy adults. Values for 36 routine items and 57 CPD items were obtained for each sample, and the results were categorized into six subgroups (N>39 in each subgroup) according to patient age (20-40, 41-60, and >60 yr) and gender (male and female), and compared with respect to age and gender differences. The majority of data items (22 of 36 routine CBC items and 44 of 57 CPD items) exhibited significant differences (P≤0.05) in their results with respect to age or gender, and several red cell-, lymphocyte-, and platelet-related data tended to decrease in women or older adults. These results provide a basis for establishing age- and gender-specific reference ranges for routine and CPD items in Sysmex XN-2000. Furthermore, these reference ranges could be used to determine clinical significance for new items of Sysmex XN-2000 in further studies. PMID:26915613

  6. Application of the Reference Method Isotope Dilution Gas Chromatography Mass Spectrometry (ID/GC/MS) to Establish Metrological Traceability for Calibration and Control of Blood Glucose Test Systems

    PubMed Central

    Andreis, Elisabeth; Küllmer, Kai

    2014-01-01

    Self-monitoring of blood glucose (BG) by means of handheld BG systems is a cornerstone in diabetes therapy. The aim of this article is to describe a procedure with proven traceability for calibration and evaluation of BG systems to guarantee reliable BG measurements. Isotope dilution gas chromatography mass spectrometry (ID/GC/MS) is a method that fulfills all requirements to be used in a higher-order reference measurement procedure. However, this method is not applicable for routine measurements because of the time-consuming sample preparation. A hexokinase method with perchloric acid (PCA) sample pretreatment is used in a measurement procedure for such purposes. This method is directly linked to the ID/GC/MS method by calibration with a glucose solution that has an ID/GC/MS-determined target value. BG systems are calibrated with whole blood samples. The glucose levels in such samples are analyzed by this ID/GC/MS-linked hexokinase method to establish traceability to higher-order reference material. For method comparison, the glucose concentrations in 577 whole blood samples were measured using the PCA-hexokinase method and the ID/GC/MS method; this resulted in a mean deviation of 0.1%. The mean deviation between BG levels measured in >500 valid whole blood samples with BG systems and the ID/GC/MS was 1.1%. BG systems allow a reliable glucose measurement if a true reference measurement procedure, with a noninterrupted traceability chain using ID/GC/MS linked hexokinase method for calibration of BG systems, is implemented. Systems should be calibrated by means of a traceable and defined measurement procedure to avoid bias. PMID:24876614

  7. A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood.

    PubMed

    Ozarda, Yesim; Ichihara, Kiyoshi; Bakan, Ebubekir; Polat, Harun; Ozturk, Nurinnisa; Baygutalp, Nurcan K; Taneli, Fatma; Guvenc, Yesim; Ormen, Murat; Erbayraktar, Zubeyde; Aksoy, Nurten; Sezen, Hatice; Demir, Meltem; Eskandari, Gulcin; Polat, Gurbuz; Mete, Nuriye; Yuksel, Hatice; Vatansev, Husamettin; Gun, Fatma; Akin, Okhan; Ceylan, Ozlem; Noyan, Tevfik; Gozlukaya, Ozgul; Aliyazicioglu, Yuksel; Kahraman, Sevim; Dirican, Melahat; Tuncer, Gul Ozlem; Kimura, Shogo; Eker, Pinar

    2017-06-15

    A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method. The blood samples were analysed within 2 hours in each laboratory using Cell Dyn and Ruby (Abbott), LH780 (Beckman Coulter), or XT-2000i (Sysmex). A panel of freshly prepared blood from 40 healthy volunteers was measured in common to assess any analyser-dependent bias in the measurements. The SD ratio (SDR) based on ANOVA was used to judge the need for partitioning RVs. RIs were computed by the parametric method with/without applying the LAVE method. Analyser-dependent bias was found for basophils (Bas), MCHC, RDW and MPV from the panel test results and thus those RIs were derived for each manufacturer. RIs were determined from all volunteers' results for WBC, neutrophils, lymphocytes, monocytes, eosinophils, MCV, MCH and platelets. Gender-specific RIs were required for RBC, haemoglobin, haematocrit, iron, UIBC and ferritin. Region-specific RIs were required for RBC, haemoglobin, haematocrit, UIBC, and TIBC. With the novel use of a freshly prepared blood panel, manufacturer-specific RIs' were derived for Bas, Bas%, MCHC, RDW and MPV. Regional differences in RIs were observed among the 7 regions of Turkey, which may be attributed to nutritional or environmental factors, including altitude.

  8. A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood

    PubMed Central

    Ozarda, Yesim; Ichihara, Kiyoshi; Bakan, Ebubekir; Polat, Harun; Ozturk, Nurinnisa; Baygutalp, Nurcan K.; Taneli, Fatma; Guvenc, Yesim; Ormen, Murat; Erbayraktar, Zubeyde; Aksoy, Nurten; Sezen, Hatice; Demir, Meltem; Eskandari, Gulcin; Polat, Gurbuz; Mete, Nuriye; Yuksel, Hatice; Vatansev, Husamettin; Gun, Fatma; Akin, Okhan; Ceylan, Ozlem; Noyan, Tevfik; Gozlukaya, Ozgul; Aliyazicioglu, Yuksel; Kahraman, Sevim; Dirican, Melahat; Tuncer, Gul Ozlem; Kimura, Shogo; Eker, Pinar

    2017-01-01

    Introduction A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). Materials and methods K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method. The blood samples were analysed within 2 hours in each laboratory using Cell Dyn and Ruby (Abbott), LH780 (Beckman Coulter), or XT-2000i (Sysmex). A panel of freshly prepared blood from 40 healthy volunteers was measured in common to assess any analyser-dependent bias in the measurements. The SD ratio (SDR) based on ANOVA was used to judge the need for partitioning RVs. RIs were computed by the parametric method with/without applying the LAVE method. Results Analyser-dependent bias was found for basophils (Bas), MCHC, RDW and MPV from the panel test results and thus those RIs were derived for each manufacturer. RIs were determined from all volunteers’ results for WBC, neutrophils, lymphocytes, monocytes, eosinophils, MCV, MCH and platelets. Gender-specific RIs were required for RBC, haemoglobin, haematocrit, iron, UIBC and ferritin. Region-specific RIs were required for RBC, haemoglobin, haematocrit, UIBC, and TIBC. Conclusions With the novel use of a freshly prepared blood panel, manufacturer-specific RIs’ were derived for Bas, Bas%, MCHC, RDW and MPV. Regional differences in RIs were observed among the 7 regions of Turkey, which may be attributed to nutritional or environmental factors, including altitude. PMID:28694726

  9. Application of the reference method isotope dilution gas chromatography mass spectrometry (ID/GC/MS) to establish metrological traceability for calibration and control of blood glucose test systems.

    PubMed

    Andreis, Elisabeth; Küllmer, Kai; Appel, Matthias

    2014-05-01

    Self-monitoring of blood glucose (BG) by means of handheld BG systems is a cornerstone in diabetes therapy. The aim of this article is to describe a procedure with proven traceability for calibration and evaluation of BG systems to guarantee reliable BG measurements. Isotope dilution gas chromatography mass spectrometry (ID/GC/MS) is a method that fulfills all requirements to be used in a higher-order reference measurement procedure. However, this method is not applicable for routine measurements because of the time-consuming sample preparation. A hexokinase method with perchloric acid (PCA) sample pretreatment is used in a measurement procedure for such purposes. This method is directly linked to the ID/GC/MS method by calibration with a glucose solution that has an ID/GC/MS-determined target value. BG systems are calibrated with whole blood samples. The glucose levels in such samples are analyzed by this ID/GC/MS-linked hexokinase method to establish traceability to higher-order reference material. For method comparison, the glucose concentrations in 577 whole blood samples were measured using the PCA-hexokinase method and the ID/GC/MS method; this resulted in a mean deviation of 0.1%. The mean deviation between BG levels measured in >500 valid whole blood samples with BG systems and the ID/GC/MS was 1.1%. BG systems allow a reliable glucose measurement if a true reference measurement procedure, with a noninterrupted traceability chain using ID/GC/MS linked hexokinase method for calibration of BG systems, is implemented. Systems should be calibrated by means of a traceable and defined measurement procedure to avoid bias.

  10. Industry Employment

    ERIC Educational Resources Information Center

    Occupational Outlook Quarterly, 2012

    2012-01-01

    This article illustrates projected employment change by industry and industry sector over 2010-20 decade. Workers are grouped into an industry according to the type of good produced or service provided by the establishment for which they work. Industry employment projections are shown in terms of numeric change (growth or decline in the total…

  11. A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach.

    PubMed

    Chou, Bin-Kuan; Gu, Haihui; Gao, Yongxing; Dowey, Sarah N; Wang, Ying; Shi, Jun; Li, Yanxin; Ye, Zhaohui; Cheng, Tao; Cheng, Linzhao

    2015-04-01

    Reprogramming human adult blood mononuclear cells (MNCs) cells by transient plasmid expression is becoming increasingly popular as an attractive method for generating induced pluripotent stem (iPS) cells without the genomic alteration caused by genome-inserting vectors. However, its efficiency is relatively low with adult MNCs compared with cord blood MNCs and other fetal cells and is highly variable among different adult individuals. We report highly efficient iPS cell derivation under clinically compliant conditions via three major improvements. First, we revised a combination of three EBNA1/OriP episomal vectors expressing five transgenes, which increased reprogramming efficiency by ≥10-50-fold from our previous vectors. Second, human recombinant vitronectin proteins were used as cell culture substrates, alleviating the need for feeder cells or animal-sourced proteins. Finally, we eliminated the previously critical step of manually picking individual iPS cell clones by pooling newly emerged iPS cell colonies. Pooled cultures were then purified based on the presence of the TRA-1-60 pluripotency surface antigen, resulting in the ability to rapidly expand iPS cells for subsequent applications. These new improvements permit a consistent and reliable method to generate human iPS cells with minimal clonal variations from blood MNCs, including previously difficult samples such as those from patients with paroxysmal nocturnal hemoglobinuria. In addition, this method of efficiently generating iPS cells under feeder-free and xeno-free conditions allows for the establishment of clinically compliant iPS cell lines for future therapeutic applications. ©AlphaMed Press.

  12. A Facile Method to Establish Human Induced Pluripotent Stem Cells From Adult Blood Cells Under Feeder-Free and Xeno-Free Culture Conditions: A Clinically Compliant Approach

    PubMed Central

    Chou, Bin-Kuan; Gu, Haihui; Gao, Yongxing; Dowey, Sarah N.; Wang, Ying; Shi, Jun; Li, Yanxin; Ye, Zhaohui; Cheng, Tao

    2015-01-01

    Reprogramming human adult blood mononuclear cells (MNCs) cells by transient plasmid expression is becoming increasingly popular as an attractive method for generating induced pluripotent stem (iPS) cells without the genomic alteration caused by genome-inserting vectors. However, its efficiency is relatively low with adult MNCs compared with cord blood MNCs and other fetal cells and is highly variable among different adult individuals. We report highly efficient iPS cell derivation under clinically compliant conditions via three major improvements. First, we revised a combination of three EBNA1/OriP episomal vectors expressing five transgenes, which increased reprogramming efficiency by ≥10–50-fold from our previous vectors. Second, human recombinant vitronectin proteins were used as cell culture substrates, alleviating the need for feeder cells or animal-sourced proteins. Finally, we eliminated the previously critical step of manually picking individual iPS cell clones by pooling newly emerged iPS cell colonies. Pooled cultures were then purified based on the presence of the TRA-1-60 pluripotency surface antigen, resulting in the ability to rapidly expand iPS cells for subsequent applications. These new improvements permit a consistent and reliable method to generate human iPS cells with minimal clonal variations from blood MNCs, including previously difficult samples such as those from patients with paroxysmal nocturnal hemoglobinuria. In addition, this method of efficiently generating iPS cells under feeder-free and xeno-free conditions allows for the establishment of clinically compliant iPS cell lines for future therapeutic applications. PMID:25742692

  13. Biological monitoring techniques for human exposure to industrial chemicals. Analysis of human fat, skin, nails, hair, blood, urine, and breath

    SciTech Connect

    Sheldon, L.; Umana, M.; Bursey, J.; Gutknecht, W.; Handy, R.; Hyldburg, P.; Michael, L.; Moseley, A.; Raymer, J.; Smith, D.

    1986-01-01

    Biological monitoring techniques for human exposure to industrial chemicals are detailed in this book which surveys and evaluates methods and procedures to identify and quantitative chemical constituents in human tissues and body fluids, including fat, skin, nails, hair, blood, urine, and breath. The book details attempts to determine 1) the feasibility of correlating preferred methods with specific tissues or fluids and/or with readily identifiable chemical characteristics, and 2) which biological matrices serve as the best indicators of past or present exposure to chemical constituents of concern. The methods studied have been evaluated of their ease and rapidly, as well as cost, accuracy and precision. Target compounds studied were those inorganic and organic chemicals basically of current or previous concern to the U.S. Environmental Protection Agency. Information provided for the methods evaluated includes sections regarding various types of instrumentation and sample preparation. Sections on method/analyte correlation suggest physical or chemical properties which might be used to predict the applicability of a given analytical method to the analysis of that chemical in a specific biological matrix.

  14. GUIDELINES FOR HOSPITALITY EDUCATION IN JUNIOR COLLEGES, A MANUAL FOR THE ESTABLISHMENT OF PROGRAMS FOR CAREERS IN THE HOTEL-MOTEL, RESTAURANT, AND INSTITUTIONAL INDUSTRIES.

    ERIC Educational Resources Information Center

    ALMARODE, RICHARD L.

    THIS REPORT DISCUSSES JUNIOR COLLEGE PROGRAMS TO MEET THE NEEDS OF STUDENTS AND INDUSTRY. THE STUDENTS RECEIVE BOTH EDUCATION AND TRAINING, WHILE INDUSTRY RECEIVES COMPETENT EMPLOYEES. BEFORE DEVELOPING THIS OCCUPATIONAL PROGRAM, THE COLLEGE SHOULD SURVEY LOCAL INDUSTRY NEEDS, OPPORTUNITIES FOR ON-THE-JOB TRAINING, POSSIBILITIES OF PART-TIME WORK…

  15. Establishment of the biochemical and endocrine blood profiles in the Majorera and Palmera dairy goat breeds: the effect of feed restriction.

    PubMed

    Lérias, Joana R; Peña, Raquel; Hernández-Castellano, Lorenzo E; Capote, Juan; Castro, Noemí; Argüello, Anastasio; Araújo, Susana S; Saco, Yolanda; Bassols, Anna; Almeida, André M

    2015-11-01

    Feed restriction, and seasonal weight loss (SWL), are major setbacks for animal production in the tropics and the Mediterranean. They may be solved through the use of autochthonous breeds particularly well adapted to SWL. It is therefore of major importance to determine markers of tolerance to feed restriction of putative use in animal selection. Two indigenous breeds from the Canary Islands, Palmera and Majorera, are commonly used by dairy goat farmers and, interestingly, have different phenotype characteristics albeit with a common ancestry. Indeed, Majorera is well adapted to feed restriction whereas the Palmera is susceptible to feed restriction. In addition, regardless of their importance in dairy production, there are only a limited number of reports relating to these breeds and, to the best of our knowledge, there is no description of their blood metabolite standard values under control conditions or as affected by feed restriction. In this study we analysed the blood metabolite profiles in Majorera and Palmera goats aiming to establish the differential responses to feed restriction between the two breeds and to characterise their metabolite standard values under control conditions. We observed significant differences in creatinine, urea, non-esterified fatty acids (NEFAs), cholesterol, IGF-1 and T3 due to underfeeding. Furthermore, a PCA analysis, revealed that animals submitted to undernutrition could be distinguished from the control groups, with the formation of three separate clusters (Palmera individuals after 22 d of subnutrition (PE22); Majorera individuals after 22 d of subnutrition (ME22) and animals assigned to control conditions (MC0, MC22, PC0 and PC22)), highlighting different responses of the two breeds to undernutrition.

  16. Predicting the hazardous dose of industrial chemicals in warm-blooded species using machine learning-based modelling approaches.

    PubMed

    Gupta, S; Basant, N; Singh, K P

    2015-06-01

    The hazardous dose of a chemical (HD50) is an emerging and acceptable test statistic for the safety/risk assessment of chemicals. Since it is derived using the experimental toxicity values of the chemical in several test species, it is highly cumbersome, time and resource intensive. In this study, three machine learning-based QSARs were established for predicting the HD50 of chemicals in warm-blooded species following the OECD guidelines. A data set comprising HD50 values of 957 chemicals was used to develop SDT, DTF and DTB QSAR models. The diversity in chemical structures and nonlinearity in the data were verified. Several validation coefficients were derived to test the predictive and generalization abilities of the constructed QSARs. The chi-path descriptors were identified as the most influential in three QSARs. The DTF and DTB performed relatively better than SDT model and yielded r(2) values of 0.928 and 0.959 between the measured and predicted HD50 values in the complete data set. Substructure alerts responsible for the toxicity of the chemicals were identified. The results suggest the appropriateness of the developed QSARs for reliably predicting the HD50 values of chemicals, and they can be used for screening of new chemicals for their safety/risk assessment for regulatory purposes.

  17. Vibration white finger, digital blood pressure, and some biochemical findings on workers operating vibrating tools in the engine manufacturing industry.

    PubMed

    Bovenzi, M

    1988-01-01

    A clinical and laboratory investigation was carried out on 76 operators using pneumatic hand grinders and impact wrenches in the engine manufacturing industry. Twenty-two vibration-exposed workers (28.9%) had no symptoms in the hands (stage 0 of the Stockholm Workshop scale), 34 (44.7%) were affected with sensorineural disturbances in the fingers (stage SN), and 20 (26.3%) suffered from vibration white finger (VWF stages 1-2-3). In the vibration-exposed operators and in 30 comparable referents not exposed to vibration, finger systolic blood pressure (FSP) was measured on a test finger and on a control finger after digit cooling to 30 degrees C and 10 degrees C. The results of the cold provocation test were expressed as percent change of FSP by cooling the test finger from 30 degrees C to 10 degrees C (FSP%t, 10 degrees) and as digital/brachial pressure index during local cooling at 10 degrees C (DPIt, 10 degrees). After cold provocation the mean values of FSP%t, 10 degrees and DPIt 10 degrees were more significantly reduced in the vibration-exposed workers with VWF than in those without VWF and the referents (p less than 0.001). The cold provocation test was found to differentiate between VWF subjects with stages 1-2 and stage 3 (p less than 0.02). It is concluded that the measurement of FSP combined with finger cooling is a useful laboratory test to diagnose objectively Raynaud's phenomenon of occupational origin. The vibration-exposed workers and the referents were also tested for serum levels of immunoglobulins and complement and for daily excretion of urinary free catecholamines. Between the reference and vibration groups no differences in the mean values of the immunologic parameters and urinary catecholamines were found. The meaning of these findings is discussed.

  18. Safety and feasibility for pediatric cardiac regeneration using epicardial delivery of autologous umbilical cord blood-derived mononuclear cells established in a porcine model system.

    PubMed

    Cantero Peral, Susana; Burkhart, Harold M; Oommen, Saji; Yamada, Satsuki; Nyberg, Scott L; Li, Xing; O'Leary, Patrick W; Terzic, Andre; Cannon, Bryan C; Nelson, Timothy J

    2015-02-01

    Congenital heart diseases (CHDs) requiring surgical palliation mandate new treatment strategies to optimize long-term outcomes. Despite the mounting evidence of cardiac regeneration, there are no long-term safety studies of autologous cell-based transplantation in the pediatric setting. We aimed to establish a porcine pipeline to evaluate the feasibility and long-term safety of autologous umbilical cord blood mononuclear cells (UCB-MNCs) transplanted into the right ventricle (RV) of juvenile porcine hearts. Piglets were born by caesarean section to enable UCB collection. Upon meeting release criteria, 12 animals were randomized in a double-blinded fashion prior to surgical delivery of test article (n=6) or placebo (n=6). The UCB-MNC (3×10(6) cells per kilogram) or control (dimethyl sulfoxide, 10%) products were injected intramyocardially into the RV under direct visualization. The cohorts were monitored for 3 months after product delivery with assessments of cardiac performance, rhythm, and serial cardiac biochemical markers, followed by terminal necropsy. No mortalities were associated with intramyocardial delivery of UCB-MNCs or placebo. Two animals from the placebo group developed local skin infection after surgery that responded to antibiotic treatment. Electrophysiological assessments revealed no arrhythmias in either group throughout the 3-month study. Two animals in the cell-therapy group had transient, subclinical dysrhythmia in the perioperative period, likely because of an exaggerated response to anesthesia. Overall, this study demonstrated that autologous UCB-MNCs can be safely collected and surgically delivered in a pediatric setting. The safety profile establishes the foundation for cell-based therapy directed at the RV of juvenile hearts and aims to accelerate cell-based therapies toward clinical trials for CHD. ©AlphaMed Press.

  19. Safety and Feasibility for Pediatric Cardiac Regeneration Using Epicardial Delivery of Autologous Umbilical Cord Blood-Derived Mononuclear Cells Established in a Porcine Model System

    PubMed Central

    Cantero Peral, Susana; Burkhart, Harold M.; Oommen, Saji; Yamada, Satsuki; Nyberg, Scott L.; Li, Xing; O’Leary, Patrick W.; Terzic, Andre; Cannon, Bryan C.; Edgerton, Sarah L.; Suddendorf, Scott H.; Krage, Steve; Rice, Mindy; Rysavy, Joseph A.; Powers, Joanna M.; Rasmussen, Boyd W.; Miller, Jennifer M.; Paulson, Traci L.; Lindquist, Rebecca K.; Reece, Chelsea L.; Miller, Angela R.; Padley, Douglas J.; Wentworth, Mark A.; Greene, Alexander C.; Andrews, Amy G.; O’Leary, Patrick W.; Olson, Timothy M.; Terzic, Andre

    2015-01-01

    Congenital heart diseases (CHDs) requiring surgical palliation mandate new treatment strategies to optimize long-term outcomes. Despite the mounting evidence of cardiac regeneration, there are no long-term safety studies of autologous cell-based transplantation in the pediatric setting. We aimed to establish a porcine pipeline to evaluate the feasibility and long-term safety of autologous umbilical cord blood mononuclear cells (UCB-MNCs) transplanted into the right ventricle (RV) of juvenile porcine hearts. Piglets were born by caesarean section to enable UCB collection. Upon meeting release criteria, 12 animals were randomized in a double-blinded fashion prior to surgical delivery of test article (n = 6) or placebo (n = 6). The UCB-MNC (3 × 106 cells per kilogram) or control (dimethyl sulfoxide, 10%) products were injected intramyocardially into the RV under direct visualization. The cohorts were monitored for 3 months after product delivery with assessments of cardiac performance, rhythm, and serial cardiac biochemical markers, followed by terminal necropsy. No mortalities were associated with intramyocardial delivery of UCB-MNCs or placebo. Two animals from the placebo group developed local skin infection after surgery that responded to antibiotic treatment. Electrophysiological assessments revealed no arrhythmias in either group throughout the 3-month study. Two animals in the cell-therapy group had transient, subclinical dysrhythmia in the perioperative period, likely because of an exaggerated response to anesthesia. Overall, this study demonstrated that autologous UCB-MNCs can be safely collected and surgically delivered in a pediatric setting. The safety profile establishes the foundation for cell-based therapy directed at the RV of juvenile hearts and aims to accelerate cell-based therapies toward clinical trials for CHD. PMID:25561683

  20. A Study of the Aquaculture Industry in Texas to Assist in Establishing Aquaculture as a Course Offering in Agricultural Science and Technology. Final Report.

    ERIC Educational Resources Information Center

    Dillingham, John; And Others

    A 1989-90 project determined the knowledge and skills necessary for employment in the aquaculture industry. The study identified technical materials and other resources available in private industry and higher education institutions. Two surveys determined the status of aquaculture in Texas school districts and identified tasks performed by…

  1. Industry Employment

    ERIC Educational Resources Information Center

    Occupational Outlook Quarterly, 2010

    2010-01-01

    This article illustrates projected employment change from an industry perspective over the 2008-2018 decade. Workers are grouped into an industry according to the type of good produced or service provided by the establishment in which they work. Industry employment projections are shown in terms of numeric change (growth or decline in the total…

  2. Establishment of Elevated Serum Levels of IL-10, IL-8 and TNF-β as Potential Peripheral Blood Biomarkers in Tubercular Lymphadenitis: A Prospective Observational Cohort Study

    PubMed Central

    Abhimanyu; Bose, Mridula; Varma-Basil, Mandira; Jain, Ashima; Sethi, Tavpritesh; Tiwari, Pradeep Kumar; Agrawal, Anurag; Banavaliker, Jayant Nagesh; Bhowmick, Kumar Tapas

    2016-01-01

    Background Tubercular lymphadenitis (TL) is the most common form of extra-pulmonary tuberculosis (TB) consisting about 15–20% of all TB cases. The currently available diagnostic modalities for (TL), are invasive and involve a high index of suspicion, having limited accuracy. We hypothesized that TL would have a distinct cytokine signature that would distinguish it from pulmonary TB (PTB), peripheral tubercular lymphadenopathy (LNTB), healthy controls (HC), other lymphadenopathies (LAP) and cancerous LAP. To assess this twelve cytokines (Tumor Necrosis Factor (TNF)—α, Interferon (IFN) -γ, Interleukin (IL)-2, IL-12, IL-18, IL-1β, IL-10, IL-6, IL-4, IL-1Receptor antagonist (IL-1Ra), IL-8 and TNF-β, which have a role in pathogenesis of tuberculosis, were tested as potential peripheral blood biomarkers to aid the diagnosis of TL when routine investigations prove to be of limited value. Methods and Findings A prospective observational cohort study carried out during 2010–2013. This was a multi-center study with three participating hospitals in Delhi, India where through random sampling cohorts were established. The subjects were above 15 years of age, HIV-negative with no predisposing ailments to TB (n = 338). The discovery cohort (n = 218) had LNTB (n = 50), PTB (n = 84) and HC (n = 84). The independent validation cohort (n = 120) composed of patients with cancerous LAP (n = 35), other LAP (n = 20) as well as with independent PTB (n = 30), LNTB (n = 15) and HC (n = 20). Eight out of twelve cytokines achieved statistical relevance upon evaluation by pairwise and ROC analysis. Further, variable selection using random forest backward elimination revealed six serum biosignatures including IL-12, IL-4, IL-6, IL-10, IL-8 and TNF-β as optimal for classifying the LNTB status of an individual. For the sake of clinical applicability we further selected a three analyte panel (IL-8, IL-10 and TNF-β) which was subjected to multinomial modeling in the independent

  3. A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug.

    PubMed

    Freese, Christian; Reinhardt, Sven; Hefner, Gudrun; Unger, Ronald E; Kirkpatrick, C James; Endres, Kristina

    2014-01-01

    In the pathogenesis of Alzheimer's disease (AD) the homeostasis of amyloid precursor protein (APP) processing in the brain is impaired. The expression of the competing proteases ADAM10 (a disintegrin and metalloproteinase 10) and BACE-1 (beta site APP cleaving enzyme 1) is shifted in favor of the A-beta generating enzyme BACE-1. Acitretin--a synthetic retinoid-e.g., has been shown to increase ADAM10 gene expression, resulting in a decreased level of A-beta peptides within the brain of AD model mice and thus is of possible value for AD therapy. A striking challenge in evaluating novel therapeutically applicable drugs is the analysis of their potential to overcome the blood-brain barrier (BBB) for central nervous system targeting. In this study, we established a novel cell-based bio-assay model to test ADAM10-inducing drugs for their ability to cross the BBB. We therefore used primary porcine brain endothelial cells (PBECs) and human neuroblastoma cells (SH-SY5Y) transfected with an ADAM10-promoter luciferase reporter vector in an indirect co-culture system. Acitretin served as a model substance that crosses the BBB and induces ADAM10 expression. We ensured that ADAM10-dependent constitutive APP metabolism in the neuronal cells was unaffected under co-cultivation conditions. Barrier properties established by PBECs were augmented by co-cultivation with SH-SY5Y cells and they remained stable during the treatment with acitretin as demonstrated by electrical resistance measurement and permeability-coefficient determination. As a consequence of transcellular acitretin transport measured by HPLC, the activity of the ADAM10-promoter reporter gene was significantly increased in co-cultured neuronal cells as compared to vehicle-treated controls. In the present study, we provide a new bio-assay system relevant for the study of drug targeting of AD. This bio-assay can easily be adapted to analyze other Alzheimer- or CNS disease-relevant targets in neuronal cells, as their

  4. Analysis using canine peripheral blood for establishing in vitro conditions for monocyte differentiation into macrophages for Leishmania chagasi infection and T-cell subset purification.

    PubMed

    Viana, Kelvinson Fernandes; Aguiar-Soares, Rodrigo Dian Oliveira; Roatt, Bruno Mendes; Resende, Lucilene Aparecida; da Silveira-Lemos, Denise; Corrêa-Oliveira, Rodrigo; Martins-Filho, Olindo Assis; Moura, Sandra Lima; Zanini, Marcos Santos; Araújo, Márcio Sobreira Silva; Reis, Alexandre Barbosa; Giunchetti, Rodolfo Cordeiro

    2013-11-15

    Canine visceral leishmaniasis (CVL) is a parasitic disease endemic in many countries, and dogs present as the major natural reservoir of the parasite, Leishmania chagasi (syn. L. infantum). Biomarkers in the canine immune system is an important technique in the course of developing vaccines and treatment strategies against CVL. New methodologies for studying the immune response of dogs during Leishmania infection and after receiving vaccines and treatments against CVL would be useful. In this context, we used peripheral blood mononuclear cells (PBMCs) from healthy dogs to evaluate procedures related to (i) establishment of in vitro conditions of monocytes differentiated into macrophages infected with L. chagasi and (ii) purification procedures of T-cell subsets (CD4(+) and CD8(+)) using microbeads. Our data demonstrated that after 5 days of differentiation, macrophages were able to induce significant phagocytic and microbicidal activity after L. chagasi infection and also showed increased frequency of parasitism and a higher parasite load. Although N-acetyl-β-d-glucosaminidase (NAG) levels presented similar levels of macrophage culture and L. chagasi infection, a progressive decrease in myeloperoxidase (MPO) levels was a hallmark over 5 days of culture. High purity levels (>90%) of CD4 and CD8 T cells were obtained on a magnetic separation column. We concluded that monocytes differentiated into macrophages at 5 days and displayed an intermediate frequency of parasitism and parasite load 72 h after L. chagasi infection. Furthermore, the purification system using canine T-lymphocyte subsets obtained after 5 days of monocyte differentiation proved efficient for CD4 or CD8 T-cell purification (≥90%). The in vitro analysis using L. chagasi-infected macrophages and purified T cells presented a prospective methodology that could be incorporated in CVL vaccine and treatment studies that aim to analyze the microbicidal potential induced by specific CD4(+) and/or CD8(+) T

  5. Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses.

    PubMed

    Negoro, Eiju; Yamauchi, Takahiro; Urasaki, Yoshimasa; Nishi, Rie; Hori, Hiroki; Ueda, Takanori

    2011-04-01

    Cytarabine (ara-C) is the key drug for treatment of acute myeloid leukemia. Since intracellular cytarabine triphosphate (ara-CTP) is an active metabolite of ara-C, factors that reduce the amount of ara-CTP are known to induce drug resistance. However, these factors do not fully explain the development of resistance to ara-C. The present study was conducted to search for new candidate ara-C resistance factors, including those that are unrelated to ara-CTP production. For this purpose, we newly established five ara-C-resistant leukemic clones from different blood cell lineage leukemic cell lines (HL-60, K562, CEM, THP1 and U937). The resistant subclones were 5-58-fold more ara-C-resistant than their parental counterparts. All of the ara-C-resistant subclones, except for ara-C-resistant CEM cells, displayed alteration of ara-CTP-related factors such as ara-C membrane transport capacity, deoxycytidine kinase activity or cytosolic nucleotidase II activity. To identify new candidate factors, we used two comprehensive approaches: DNA microarray and proteome analyses. The DNA microarray analysis revealed eight genes (C19orf2, HSPA8, LGALS1, POU4F3, PSAP, AKT1, MBC2 and CACNA2D3) that were altered in all five ara-C-resistant lines compared to parental cells. Both proteome and DNA microarray analyses further detected a reduced protein level of stathmin1 in the ara-C-resistant CEM subclone compared to its parental line. Thus, the present findings suggested the involvement of novel multiple mechanisms in mediating the ara-C resistance of leukemic cells. The role of some of these molecules in resistance is still unclear.

  6. Identification and antagonistic activity of lactic acid bacteria occurring in porcine blood from industrial slaughterhouses--a preliminary study.

    PubMed

    Dàvila, Eduard; Zamora, Lucero M; Pla, Maria; Carretero, Carmen; Parés, Dolors

    2006-03-15

    Ninety-seven lactic acid bacteria (LAB) were isolated from slaughterhouse porcine blood in order to select autochthonous LAB strains for use as biopreservatives of this by-product. They were identified by 16S rDNA sequencing; and their inhibition capacity was determined against four bacterial species frequently found in contaminated blood, i.e. Staphylococcus aureus, Escherichia coli, Pseudomonas fluorescens and Bacillus spp. The taxonomic study showed an unexpected low diversity of LAB in blood, i.e. only 8 different species were found, from which just 4, i.e. Enterococcus raffinosus, Lactobacillus murinus, Lactobacillus reuteri and Lactococcus garvieae, amounted to more than 90% of all isolates. Inhibition tests in solid culture media proved that S. aureus and Bacillus spp. were inhibited by most LAB strains obtained from porcine blood. E. coli was the indicator less affected by the isolated LAB species. Several isolates efficiently inhibited the growth of all tested indicators.

  7. The Establishment of a National Industrial Wastes Inventory. Hearing Before a Subcommittee of the Committee on Government Operations, H.R. 91st Congress, September 17, 1970.

    ERIC Educational Resources Information Center

    Congress of the U. S., Washington, DC. House Committee on Government Operations.

    Presented in this bulletin is the test of the hearing before the Conservation and Natural Resources Subcommittee of the Committee on Government Operations, United States House of Representatives, ninety-first Congress, concerning a national inventory of industrial wastes. The hearing was held September 17, 1970, to examine the long delay of the…

  8. An Examination of the Changing Hydrological Environment in Choctaw County Mississippi since 1995, With a Focus on an Area Surrounding an Industrial Complex established in 1998.

    NASA Astrophysics Data System (ADS)

    Foote, J.; Schmitz, D.

    2015-12-01

    Since 1995, Choctaw County in Mississippi has experienced a number of major changes, including population growth and the addition to industrial complexes, including surface mining. The growth of population can put a strain on the available surface and ground water drinking resources. The use of the water resources by the industrial complexes by altering the landscape above and around the water resources can further strain the water supply, as well as affect the water chemistry. The population and industrial complexes of Choctaw County utilizes much of its water from an aquifer system in the Tertiary age Wilcox unit of the Mississippi Embayment, which includes the Meridian Upper-Wilcox Aquifer, the Middle Wilcox Aquifer and the Lower Wilcox Aquifer. Utilizing 20 years of physical chemistry (P-Chem) analysis and potentiometric ground water level records of Choctaw County public water wells as well as industrial P-Chem analysis and surface water and ground water level records from Choctaw County, this study examined the changes to the hydrological environment that has taken place since the increase in population and addition of significant additional industries since 1995. Analysis of the surface and groundwater data shows that over the last 20 years, there has been a drop in the potentiometric surface of the Meridian Upper Wilcox Aquifer, Middle Wilcox Aquifer, and the Lower Wilcox Aquifer. The analysis also shows changes in the in the water chemistry of the surface and ground water supplies, changes such as a general decrease in free carbon dioxide, a decrease in chloride, and fluxuations in the Alkalinity (T) as CaCO­3.

  9. [Engineering education reform plan created by Prof. Dr. Shimizu and establishment of Nagoya Municipal Science Museum--regarding cooperative education between universities and industries in Japan after the Second World War].

    PubMed

    Mabuchi, Koichi

    2014-07-01

    This paper gives an account of Prof. Dr. Kinji Shimizu, the first president of Nagoya Institute of Technology, and his establishment of Nagoya Municipal Science Museum. After graduating from the Electrical Engineering Department of Kyoto Imperial University in 1923, Shimizu was impressed by the German Museum in Munich during his stay there as a student in 1932. It's the first time that he learned the education in cooperation with industries. Just after the Second World War, he became director general of the Ministry of Education. However, new education system given by the United States focused not on developing practical ability but on gaining the basic knowledge, which is contrary to what he expected. Then, he contributed to the establishment of the Japanese Society for Engineering Education, besides working as the president of Nagoya Institute of Technology in the earlier 1950s. His idea was supported by industries for the economic growth. Throughout his career, Prof. Dr. Shimizu was convinced that practical engineering education would benefit Japan, and wanted to introduce cooperative education between universities and industries, along the lines of the same system in Germany and the United States. With this vision he founded Nagoya Municipal Science Museum in cooperation with local industries and local government as his final achievement. The museum was completed in 1964.

  10. Establishment of a simple and rapid identification method for Listeria spp. by using high-resolution melting analysis, and its application in food industry.

    PubMed

    Ohshima, Chihiro; Takahashi, Hajime; Phraephaisarn, Chirapiphat; Vesaratchavest, Mongkol; Keeratipibul, Suwimon; Kuda, Takashi; Kimura, Bon

    2014-01-01

    Listeria monocytogenes is the causative bacteria of listeriosis, which has a higher mortality rate than that of other causes of food poisoning. Listeria spp., of which L. monocytogenes is a member, have been isolated from food and manufacturing environments. Several methods have been published for identifying Listeria spp.; however, many of the methods cannot identify newly categorized Listeria spp. Additionally, they are often not suitable for the food industry, owing to their complexity, cost, or time consumption. Recently, high-resolution melting analysis (HRMA), which exploits DNA-sequence differences, has received attention as a simple and quick genomic typing method. In the present study, a new method for the simple, rapid, and low-cost identification of Listeria spp. has been presented using the genes rarA and ldh as targets for HRMA. DNA sequences of 9 Listeria species were first compared, and polymorphisms were identified for each species for primer design. Species specificity of each HRM curve pattern was estimated using type strains of all the species. Among the 9 species, 7 were identified by HRMA using rarA gene, including 3 new species. The remaining 2 species were identified by HRMA of ldh gene. The newly developed HRMA method was then used to assess Listeria isolates from the food industry, and the method efficiency was compared to that of identification by 16S rDNA sequence analysis. The 2 methods were in coherence for 92.6% of the samples, demonstrating the high accuracy of HRMA. The time required for identifying Listeria spp. was substantially low, and the process was considerably simplified, providing a useful and precise method for processing multiple samples per day. Our newly developed method for identifying Listeria spp. is highly valuable; its use is not limited to the food industry, and it can be used for the isolates from the natural environment.

  11. Epidemiological studies of neurological signs and symptoms and blood pressure in populations near the industrial methylmercury contamination at Minamata, Japan.

    PubMed

    Yorifuji, Takashi; Tsuda, Toshihide

    2016-07-03

    Severe methylmercury exposure occurred in Minamata, Japan. Only a limited number of epidemiological studies related to that exposure have been carried out. The evidence that methylmercury is cardiotoxic is very limited, and these studies provide only minimal support for that hypothesis. We therefore analyzed the data both from an investigation in Minamata and neighboring communities in 1971 and an investigation in 1974 in another area simultaneously. We included a total of 3,751 participants. We examined the association of residential area with neurological signs or blood pressure using logistic regression or multiple linear regression models, adjusting for sex and age. We found that the prevalence of neurological signs and symptoms was elevated in the Minamata area (high-exposure), followed by the Goshonoura area (medium-exposure). Moreover, blood pressure was elevated in residents of the Minamata area.

  12. A comprehensive experimental study of industrial, domestic and environmental interferences with the forensic luminol test for blood.

    PubMed

    Creamer, J I; Quickenden, T I; Apanah, M V; Kerr, K A; Robertson, P

    2003-01-01

    This paper presents the fi rst comprehensive and quantitative study of substances that interfere with the forensic luminol test for blood. Two hundred and fifty substances have been selected on the basis of modern lifestyles and of contiguity with crime scenes. The intensity of the chemiluminescence produced by each substance has been measured relative to that of haemoglobin and the peak wavelength shift has also been determined. The following is a short list of nine substances that produce chemiluminescence intensities comparable with that of haemoglobin: turnips, parsnips, horseradishes, commercial bleach (NaClO), copper metal, some furniture polishes, some enamel paints, and some interior fabrics in motor vehicles. Care needs to be taken when the luminol test for blood is used in the presence of these substances.

  13. X-Ray Diffraction Residual Stress Analysis: One of the Few Advanced Physical Measuring Techniques That Have Established Themselves for Routine Application in Industry

    NASA Astrophysics Data System (ADS)

    Nierlich, Wolfgang; Gegner, Jürgen

    The conventional procedure of X-ray diffraction (XRD) residual stress measurement is improved by means of a modification of the beam path of the diffractometer and an iterative technique that includes a pre-analysis of the nearpeak line-profile. The achieved short measuring times of 5 and around 10 min per residual stress value and retained austenite content, respectively, serve as precondition for routine industrial applications over the last three decades within SKF. The line width represents a measure of material ageing within the lifetime cycle of a rolling bearing: calibration curves for the (near-) surface and the sub-surface failure mode are presented. Material response analysis permits differentiation of these failure modes and between low- and high-cycle fatigue.

  14. Contracting in the national interest: Establishing the legal framework for the interaction of science, government, and industry at a nuclear weapons laboratory

    SciTech Connect

    Furman, N.S.

    1988-04-01

    Sandia National Laboratories, the nation's nuclear ordnance laboratory, is operated on a no-profit, no-fee basis by ATandT Technologies, Inc., as a prime contractor for the Department of Energy. This unique arrangement began in 1949 when President Harry Truman personally requested that ATandT assume management of the nuclear weapons laboratory as a service in the national interest. The story of how this unusual relationship came about makes for an interesting chapter in the annals of US legal and institutional history. This report describes the historical background, political negotiations, and prime contract provisos that established the legal framework for the Labs.

  15. Autologous blood donor screening indicated a lower prevalence of viral hepatitis in East vs West Germany: epidemiological benefit from established health resources.

    PubMed

    Wiegand, J; Luz, B; Mengelkamp, A-K; Moog, R; Koscielny, J; Halm-Heinrich, I; Susemihl, C; Bentzien, F; Diekmann, J; Wernet, D; Karger, R; Angert, K; Schmitt-Thomssen, A; Kiefel, V; Lutter, K; Hesse, R; Kätzel, R; Opitz, A; Luhm, J; Barz, D; Leib, U; Matthes, G; Tillmann, H L

    2009-10-01

    Prevalence data concerning viral hepatitis and human immunodeficiency virus (HIV) in the general population are usually scarce. We aimed for a large cohort representative of the general population that required little funding. Autologous blood donors are relatively representative of the general population, and are tested for viral hepatitis and HIV in many countries. However, frequently these data are not captured for epidemiologic purposes. We analysed data from well over 35,000 autologous blood donors as recorded in 21 different transfusion centres for anti-hepatitis C virus (HCV), HBsAg and anti-HIV, as well as TPHA if available. We found a lower prevalence of hepatitis B virus and HCV in East vs West Germany, 0.2%vs 0.32% and 0.16%vs 0.32% respectively, which confirms earlier data in smaller cohorts, thus supporting the value of our approach. HIV was too rare to disclose significant differences, 0.01%vs 0.02%. TPHA was higher in East (0.34%) vs West Germany (0.29%) without significant differences. HCV was more frequent in women vs men. Transfusion institutes managing autologous blood donations should be used as a resource for epidemiological data relating to viral hepatitis and HIV, if such testing is performed routinely. This approach generates data relating to the general population with special emphasis on undiagnosed cases.

  16. Milk production, intake, digestion, blood parameters, and ingestive behavior of cows supplemented with by-products from the biodiesel industry.

    PubMed

    Gonzaga Neto, Severino; Oliveira, Ronaldo Lopes; de Lima, Francisco Helton Sá; de Medeiros, Ariosvaldo Nunes; Bezerra, Leilson Rocha; Viégas, Júlio; do Nascimento, Nilton Guedes; de Freitas Neto, Marcondes Dias

    2015-01-01

    This study aimed to evaluate the intake, digestion, blood parameters, and feeding behavior of crossbred dairy cows (Holstein × Gir) managed on Panicum maximum Jacq. cv. Tanzania-1 and provided supplementation with groundnut cake, sunflower cake, or palm kernel cake (to replace soybean meal). Sixteen cows were randomly assigned in a Latin square design with four treatments and four experimental periods. The consumption of nutrients from the pasture did not vary between experimental treatments. Cows receiving the palm kernel cake supplement had a reduced crude protein, non-fibrous carbohydrate, and total digestible nutrient intake and an increase in the average consumption of ether extract. There was also a reduction in the digestibility of dry matter. The inclusion of supplements in the diet did not influence the average time spent eating, ruminating, or resting. The mean values of respiratory and heart rates showed thermal comfort during the trial period. There was a reduction in blood urea nitrogen with palm kernel cake supplementation, and the values of total protein, albumin, and glucose were also significantly different with this supplement. It is recommended that cakes of groundnut cake and sunflower cake seed be used for a total replacement of soybean meal supplements for lactating cows, but the use of palm kernel cake is not recommended.

  17. Body mass index, blood pressure, and glucose and lipid metabolism among permanent and fixed-term workers in the manufacturing industry: a cross-sectional study.

    PubMed

    Inoue, Mariko; Minami, Masahide; Yano, Eiji

    2014-02-27

    Temporary employment, a precarious form of employment, is recognized as social determinant of poor health. However, evidence supporting precarious employment as a risk factor for health is mainly obtained from subjective data. Studies using objective clinical measurement data in the assessment of health status are limited. This study compared body mass index (BMI), lipid and glucose metabolism, and health-related lifestyle factors between permanent workers and fixed-term workers employed in the manufacturing industry. Data of 1,701 male manufacturing industry workers <50 years old in Japan were collected and analyzed. Anthropometric data were BMI, calculated using measured height and weight of study participants, and blood pressure. For lipid metabolism, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels were determined. For glucose metabolism, fasting plasma glucose and hemoglobin A1c (HbA1c) levels were measured. Multiple regression analysis adjusted for age and lifestyle factors was performed. BMI was significantly higher in permanent workers (22.9 kg/m2) compared with fixed-term workers (22.4 kg/m2). The leaner population (BMI < 18.5) was greater among fixed-term workers (8.3%) compared with permanent workers (4.0%), whereas the overweight population (BMI ≥ 25.0) was greater among permanent workers (21.4%) compared with fixed-term workers (18.1%). Although fixed-term workers tended not to be overweight, regression analysis adjusted for age and lifestyle factors suggested that fixed-term employment was significantly associated with higher blood pressure (systolic β = 2.120, diastolic β = 2.793), triglyceride (β = 11.147), fasting blood glucose (β = 2.218), and HbA1c (β = 0.107) compared with permanent workers (all p < 0.01). Fixed-term workers showed more health risks, such as poorer blood pressure and lipid and glucose metabolism, even when adjusted for age and lifestyle

  18. Body mass index, blood pressure, and glucose and lipid metabolism among permanent and fixed-term workers in the manufacturing industry: a cross-sectional study

    PubMed Central

    2014-01-01

    Background Temporary employment, a precarious form of employment, is recognized as social determinant of poor health. However, evidence supporting precarious employment as a risk factor for health is mainly obtained from subjective data. Studies using objective clinical measurement data in the assessment of health status are limited. This study compared body mass index (BMI), lipid and glucose metabolism, and health-related lifestyle factors between permanent workers and fixed-term workers employed in the manufacturing industry. Methods Data of 1,701 male manufacturing industry workers <50 years old in Japan were collected and analyzed. Anthropometric data were BMI, calculated using measured height and weight of study participants, and blood pressure. For lipid metabolism, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels were determined. For glucose metabolism, fasting plasma glucose and hemoglobin A1c (HbA1c) levels were measured. Multiple regression analysis adjusted for age and lifestyle factors was performed. Results BMI was significantly higher in permanent workers (22.9 kg/m2) compared with fixed-term workers (22.4 kg/m2). The leaner population (BMI < 18.5) was greater among fixed-term workers (8.3%) compared with permanent workers (4.0%), whereas the overweight population (BMI ≥ 25.0) was greater among permanent workers (21.4%) compared with fixed-term workers (18.1%). Although fixed-term workers tended not to be overweight, regression analysis adjusted for age and lifestyle factors suggested that fixed-term employment was significantly associated with higher blood pressure (systolic β = 2.120, diastolic β = 2.793), triglyceride (β = 11.147), fasting blood glucose (β = 2.218), and HbA1c (β = 0.107) compared with permanent workers (all p < 0.01). Conclusions Fixed-term workers showed more health risks, such as poorer blood pressure and lipid and glucose metabolism

  19. Inca of the blood, Inca of the soul: embodiment, emotion, and racialization in the Peruvian mystical tourist industry.

    PubMed

    Hill, Michael

    2008-01-01

    In the context of the globalizing New Age movement and of the "turismo mistico" (mystical tourism) industry emanating from Peru, white and mestizo New Age practitioners and tourists fashion ideologies emphasizing the spiritual energy which supposedly resides in Quechua bodies, even as they freely appropriate Quechua cosmology and ritual for a hybridized New Age Andean spirituality. This case shows how racialized structural inequalities are expressed and experienced by tourists and New Age movement leaders through particular, essentialist representations of the body and through a common repertoire of emotional responses to inequality, commodification, and privilege. The paper provides an ethnographic account of how racialization may be perpetuated, negotiated, and resisted through religious systems, particularly through the work of constructing ideologies and experiences of the body and of emotional subjectivity.

  20. Strategies for establishing policy, environmental, and systems-level interventions for managing high blood pressure and high cholesterol in health care settings: a qualitative case study.

    PubMed

    Matson Koffman, Dyann; Granade, Sharon A; Anwuri, Victoria V

    2008-07-01

    Policy, environmental, and systems-level interventions are part of a comprehensive approach to managing high blood pressure and high cholesterol, which are key risk factors for heart disease and stroke. In this qualitative case study, we identified clinical practices in health care organizations that used policy, environmental, or systems-level interventions to improve patient outcomes for these conditions. Our 4 objectives were to describe 1) policy, environmental, and systems-level interventions; 2) enabling factors and barriers that affected implementation; 3) methods for evaluating the success of the intervention; and 4) lessons learned from the health care practices that implemented these interventions. Through literature review and expert guidance, we identified 34 health care practices that used policy, environmental, and systems-level interventions to manage high blood pressure and high cholesterol. In 2003, we conducted case study interviews with key informants for 9 health care practices that 1) demonstrated improved patient outcomes for blood pressure or cholesterol; 2) implemented the interventions for at least 1 year; and 3) remained committed to sustaining or institutionalizing interventions. We taped and transcribed the interviews and used Centers for Disease Control and Prevention EZ-Text software (www.cdc.gov/hiv/software/ez-text.htm) to code, categorize, and analyze the responses. The health care practices we studied implemented specialized lipid clinics, disease management programs, physician reminder systems, and participation in the Health Resources and Services Administration's Bureau of Primary Care Health Disparities Collaboratives. All practices used comprehensive systems for patient care that were well-defined, measurable, and linked to desirable patient outcomes. Most relied on data systems to identify patients targeted for the interventions and practice areas that needed improvement, and to track the progress of patients and

  1. First Indian study to establish safety of immediate-spin crossmatch for red blood cell transfusion in antibody screen-negative recipients

    PubMed Central

    Tiwari, Aseem Kumar; Aggarwal, Geet; Dara, Ravi C.; Arora, Dinesh; Gupta, Gautam Kumar; Raina, Vimarsh

    2017-01-01

    BACKGROUND AND OBJECTIVES: The US Food and Drug Administration and American Association of Blood Banks approved the type and screen approach in 1980s, long after antibody screen (AS) was introduced in 1950s. The present study omits conventional anti-human globulin (AHG) crossmatch and replaces it with immediate-spin (IS) crossmatch as part of pretransfusion testing in AS-negative patients to study the safety and effectiveness of IS crossmatch in recipients. MATERIALS AND METHODS: This prospective longitudinal study was conducted on over 5000 red cell units transfused to AS-negative patients admitted to the hospital. Pretransfusion testing comprised blood grouping and AS followed by IS crossmatch, at the time of issue of red cell unit. The patients were transfused IS compatible red cell units. AHG crossmatch was performed posttransfusion for all red cell units. Any incompatible AHG crossmatch was followed up as suspected transfusion reaction. RESULTS: A total of 5023 red cell units were transfused to 2402 patients with negative AS. 99.7% IS compatible red cell units were also compatible on posttransfusion AHG crossmatch. Anti-P1 alloantibody was identified in one patient who was transfused two IS crossmatch compatible units but later both units were incompatible on AHG crossmatch. There was no clinical or serological sign of hemolysis in the patient. CONCLUSION: In AS-negative patients, IS crossmatch is as safe as conventional AHG crossmatch and can, therefore, replace conventional AHG crossmatch protocol. PMID:28316439

  2. Geographical patterns in blood lead in relation to industrial emissions and traffic in Swedish children, 1978–2007

    PubMed Central

    Stroh, Emilie; Lundh, Thomas; Oudin, Anna; Skerfving, Staffan; Strömberg, Ulf

    2009-01-01

    Background Blood lead concentrations (B-Pb) were measured in 3 879 Swedish school children during the period 1978–2007. The objective was to study the effect of the proximity to lead sources based on the children's home and school location. Methods The children's home address and school location were geocoded and their proximity to a lead smelter and major roads was calculated using geographical information system (GIS) software. All the statistical analyses were carried out using means of generalized log-linear modelling, with natural-logarithm-transformed B-Pb, adjusted for sex, school year, lead-exposing hobby, country of birth and, in the periods 1988–1994 and 1995–2007, parents' smoking habits. Results The GIS analysis revealed that although the emission from the smelter and children's B-Pb levels had decreased considerably since 1978, proximity to the lead smelter continued to affect levels of B-Pb, even in recent years (geometric mean: near smelter: 22.90 μg/l; far from smelter 19.75 μg/l; p = 0.001). The analysis also revealed that proximity to major roads noticeably affected the children's B-Pb levels during the period 1978–1987 (geometric mean near major roads: 44.26 μg/l; far from roads: 38.32 μg/l; p = 0.056), due to the considerable amount of lead in petrol. This effect was, however, not visible after 1987 due to prohibition of lead in petrol. Conclusion The results show that proximity to the lead smelter still has an impact on the children's B-Pb levels. This is alarming since it could imply that living or working in the vicinity of a former lead source could pose a threat years after reduction of the emission. The analysis also revealed that urban children exposed to lead from traffic were only affected during the early period, when there were considerable amounts of lead in petrol, and that the prohibition of lead in petrol in later years led to reduced levels of lead in the blood of urban children. PMID:19591669

  3. Reduction of Isoagglutinin in Intravenous Immunoglobulin (IVIG) Using Blood Group A- and B-Specific Immunoaffinity Chromatography: Industry-Scale Assessment.

    PubMed

    Gerber, Simon; Gaida, Annette; Spiegl, Nicole; Wymann, Sandra; Antunes, Adriano Marques; Menyawi, Ibrahim El; Zurbriggen, Brigitte; Hubsch, Alphonse; Imboden, Martin

    2016-10-01

    Hemolysis, a rare but potentially serious complication of intravenous immunoglobulin (IVIG) therapy, is associated with the presence of antibodies to blood groups A and B (isoagglutinins) in the IVIG product. An immunoaffinity chromatography (IAC) step in the production process could decrease isoagglutinin levels in IVIG. Our objectives were to compare isoagglutinin levels in a large number of IVIG (Privigen(®)) batches produced with or without IAC and to assess the feasibility of the production process with an IAC step on an industrial scale. The IAC column comprised a blend of anti-A and anti-B resins formed by coupling synthetic blood group antigens (A/B-trisaccharides) to a base bead matrix, and was introduced towards the end of the industrial-scale IVIG manufacturing process. Isoagglutinin levels in IVIG were determined by anti-A and anti-B hemagglutinin direct and indirect methods according to the European Pharmacopoeia (Ph. Eur.) and an isoagglutinin flow cytometry assay. IVIG product quality was assessed with respect to the retention of immunoglobulin G (IgG) subclasses, specific antibodies, and removal of IgM using standardized procedures. The IAC step reduced isoagglutinins in IVIG by two to three titer steps compared with lots produced without IAC. The median anti-A and anti-B titers with IAC were 1:8 and 1:4, respectively, when measured by the Ph. Eur. direct method, and 1:2 and <1, respectively, when measured by the Ph. Eur. indirect method. The isoagglutinin flow cytometry assay showed an 87-90 % reduction in isoagglutinins in post-IAC versus pre-IAC fractions. IAC alone reduced anti-A and anti-B of the IgMs isotype by 92.5-97.8 % and 95.4-99.2 %, respectively. Other product quality characteristics were similar with and without IAC. IAC is an effective method for reducing isoagglutinin levels in IVIG, and it is feasible on an industrial scale.

  4. Establishing and evaluating bar-code technology in blood sampling system: a model based on human centered human-centered design method.

    PubMed

    Chou, Shin-Shang; Yan, Hsiu-Fang; Huang, Hsiu-Ya; Tseng, Kuan-Jui; Kuo, Shu-Chen

    2012-01-01

    This study intended to use a human-centered design study method to develop a bar-code technology in blood sampling process. By using the multilevel analysis to gather the information, the bar-code technology has been constructed to identify the patient's identification, simplify the work process, and prevent medical error rates. A Technology Acceptance Model questionnaire was developed to assess the effectiveness of system and the data of patient's identification and sample errors were collected daily. The average scores of 8 items users' perceived ease of use was 25.21(3.72), 9 items users' perceived usefulness was 28.53(5.00), and 14 items task-technology fit was 52.24(7.09), the rate of patient identification error and samples with order cancelled were down to zero, however, new errors were generated after the new system deployed; which were the position of barcode stickers on the sample tubes. Overall, more than half of nurses (62.5%) were willing to use the new system.

  5. Establishment of loop-mediated isothermal amplification (LAMP) for rapid detection of Brucella spp. and application to milk and blood samples.

    PubMed

    Song, Liuyan; Li, Juntao; Hou, Shuiping; Li, Xunde; Chen, Shouyi

    2012-09-01

    Brucella spp. are facultative intracellular bacteria that infect humans and animals. In this study, the loop-mediated isothermal amplification (LAMP) was used to detect the Brucella-specific gene omp25. Reaction conditions were optimized as temperature 65°C, reaction time 60 min, Mg(2+) concentration 8.0 mmol/L, polymerase content Bst DNA, 0.5 μL, deoxyribonucleotide concentration 1.6 mmol/L, and inner/outer primer ratio 1:8. The LAMP method was evaluated with 4 Brucella species and 29 non-Brucella bacteria species. Positive reactions were observed on all the 4 Brucella species but not on any non-Brucella species. The limit of detection of the LAMP method was 3.81 CFU Brucella spp. Using the LAMP method, 7 of 110 raw milk samples and 5 of 59 sheep blood samples were detected positive of Brucella spp. Results indicated that LAMP is a fast, specific, sensitive, inexpensive, and suitable method for diagnosis of Brucella spp. infection.

  6. Distribution of certain drug products by registered blood establishments and comprehensive hemophilia diagnostic treatment centers that qualify as health care entities; Prescription Drug Marketing Act of 1987; Prescription Drug Amendments of 1992; policies, requirements and administrative procedures. Final rule.

    PubMed

    2008-10-09

    The Food and Drug Administration (FDA) is amending its regulations to allow certain registered blood establishments and comprehensive hemophilia diagnostic treatment centers that are also health care entities to distribute certain drug products. The final rule amends limited provisions of the regulations implementing the Prescription Drug Marketing Act of 1987 (PDMA), as modified by the Prescription Drug Amendments of 1992 (PDA). These regulations, among other things, restrict the sale, purchase, or trade of, or the offer to sell, purchase, or trade, prescription drugs purchased by hospitals and other health care entities.

  7. Increased cytogenetic damage in a zone in transition from agricultural to industrial use: Comprehensive analysis of the micronucleus test in peripheral blood lymphocytes.

    PubMed

    Montero, Regina; Serrano, Luis; Araujo, Antonio; Dávila, Víctor; Ponce, Johny; Camacho, Rafael; Morales, Eduardo; Méndez, Alejandra

    2006-09-01

    A complex situation of chemical exposure has been described in México in a zone that is in transition from rural activities towards intensive industrialization, which has brought environmental pollution: chloroform, methylene chloride, indigo and toluene are some of the pollutants found in the Atoyac and Xochiac rivers. A biomonitoring study was planned in order to establish whether there was a biological effect due to the environmental situation. Communities where leukaemia and thrombocytopenic purpura cases have been reported were included in the study, as well as other communities where such cases have not been described. Three occupations were distinguished, according to chemical exposure: industrial workers, agricultural workers and workers in households, education and commerce. A comprehensive analysis in the micronucleus (MN) test was used to study genotoxicity biomarkers. Two metabolic polymorphisms were determined, namely, glutathione transferase mu1 (GSTM1) and theta1 (GSTT1), which are relevant when oxidative responses are involved. Increased genotoxic damage was found, including cells with >1 MN, >1 chromatin bud, and nucleoplasmic bridges. The genotoxic damage was differentially distributed in the regions studied, being more affected those that are closer to the Atoyac and Xochiac rivers, indicating an effect due to environmental exposure to the contaminants present in the rivers. Further characterization of the exposure regimes in these communities will be done in order to contribute to the alleviation of the health risks that environmental pollution is posing on the inhabitants of this area.

  8. Requirements for blood and blood components intended for transfusion or for further manufacturing use. Final rule.

    PubMed

    2015-05-22

    The Food and Drug Administration (FDA) is amending the regulations applicable to blood and blood components, including Source Plasma, to make the donor eligibility and testing requirements more consistent with current practices in the blood industry, to more closely align the regulations with current FDA recommendations, and to provide flexibility to accommodate advancing technology. In order to better assure the safety of the nation's blood supply and to help protect donor health, FDA is revising the requirements for blood establishments to test donors for infectious disease, and to determine that donors are eligible to donate and that donations are suitable for transfusion or further manufacture. FDA is also requiring establishments to evaluate donors for factors that may adversely affect the safety, purity, and potency of blood and blood components or the health of a donor during the donation process. Accordingly, these regulations establish requirements for donor education, donor history, and donor testing. These regulations also implement a flexible framework to help both FDA and industry to more effectively respond to new or emerging infectious agents that may affect blood product safety.

  9. Establishment of selected baseline blood chemistry and hematologic parameters in captive and wild-caught African white-backed vultures (Gyps africanus).

    PubMed

    Naidoo, V; Diekmann, M; Wolters, K; Swan, G E

    2008-07-01

    Despite the devastating collapse of three vulture populations on the Asian subcontinent as a result of their exposure to diclofenac, there is little available information on the normal physiology of many vulture species, including the African White-backed Vulture (Gyps africanus). Such information is needed to fully understand mechanisms for toxicity and to identify and prevent future health problems. The aim of this study was to establish baseline parameters for hematologic and selected serum chemistry parameters for this model species for further studies into the toxicity of diclofenac. Captive nonreleasable and wild African White-backed Vultures were used to determine reference values. For hematology, erythrocyte counts, hemoglobin concentration, hematocrit, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin concentration, and total and differential leukocyte counts were measured. Chemical analytes measured included sodium, potassium, calcium, albumin, and globulin concentrations, aspartate aminotransferase, creatine kinase, and alanine aminotransferase activities. Uric acid and urea concentrations and the urea:uric acid ratio also were evaluated. Values are presented as means, standard deviations, and reference intervals. The serum chemistry parameters selected may provide a starting point for the evaluation of changes in renal and hepatic function; these organ systems are most severely affected by diclofenac. Results were also compared with values reported for G. africanus nestlings, and from these results it is evident that the clinical pathologic parameters are age related. This indicates that the use of nestling values for the evaluation of clinical pathologic findings in adults may be unreliable and could lead to incorrect assumptions.

  10. Establishing operations

    PubMed Central

    Michael, Jack

    1993-01-01

    The first two books on behavior analysis (Skinner, 1938; Keller & Schoenfeld, 1950) had chapter-length coverage of motivation. The next generation of texts also had chapters on the topic, but by the late 1960s it was no longer being given much treatment in the behavior-analytic literature. The present failure to deal with the topic leaves a gap in our understanding of operant functional relations. A partial solution is to reintroduce the concept of the establishing operation, defined as an environmental event, operation, or stimulus condition that affects an organism by momentarily altering (a) the reinforcing effectiveness of other events and (b) the frequency of occurrence of that part of the organism's repertoire relevant to those events as consequences. Discriminative and motivative variables can be distinguished as follows: The former are related to the differential availability of an effective form of reinforcement given a particular type of behavior; the latter are related to the differential reinforcing effectiveness of environmental events. An important distinction can also be made between unconditioned establishing operations (UEOs), such as food deprivation and painful stimulation, and conditioned establishing operations (CEOs) that depend on the learning history of the organism. One type of CEO is a stimulus that has simply been paired with a UEO and as a result may take on some of the motivative properties of that UEO. The warning stimulus in avoidance procedures is another important type of CEO referred to as reflexive because it establishes its own termination as a form of reinforcement and evokes the behavior that has accomplished such termination. Another CEO is closely related to the concept of conditional conditioned reinforcement and is referred to as a transitive CEO, because it establishes some other stimulus as a form of effective reinforcement and evokes the behavior that has produced that other stimulus. The multiple control of human

  11. In vivo assessment of an industrial waste product as a feed additive in dairy cows: Effects of larch (Larix decidua L.) sawdust on blood parameters and milk composition.

    PubMed

    Tedesco, D; Garavaglia, L; Spagnuolo, M S; Pferschy-Wenzig, E M; Bauer, R; Franz, C

    2015-12-01

    When larch (Larix spp.) is processed in the wood industry, the sawdust is currently disposed of as waste or used as combustible material, even though it is rich in biologically active compounds. In this study the effect of larch sawdust supplementation on blood parameters as well as milk composition was examined in healthy mid-lactating dairy cows. Twenty-four multiparous Italian Friesian dairy cows were assigned to groups receiving either 300 g/day/cow of larch sawdust or a control diet, and treatments were continued for a 20 day period. Milk parameters were unaffected by treatment. A lower plasma total protein concentration was observed and can be attributed to a decrease in globulin concentration. A lower plasma urea concentration was also detected in the larch group. Moreover, biomarkers of liver function were influenced by the treatment. Total bilirubin was lower in larch-treated animals, and cholesterol tended to be lower. In addition, an interaction between day and treatment was observed for very low density lipoprotein. The concentration of other parameters, including reactive oxygen metabolites, superoxide dismutase, glutathione peroxidase and nitrotyrosine, did not differ between treatments. The observed benefits, together with the good palatability, make larch sawdust a promising candidate for the development of beneficial feed supplements for livestock. Further studies will be useful, particularly to evaluate its efficacy in different health conditions.

  12. Association of long-term exposure to local industry- and traffic-specific particulate matter with arterial blood pressure and incident hypertension.

    PubMed

    Fuks, Kateryna B; Weinmayr, Gudrun; Hennig, Frauke; Tzivian, Lilian; Moebus, Susanne; Jakobs, Hermann; Memmesheimer, Michael; Kälsch, Hagen; Andrich, Silke; Nonnemacher, Michael; Erbel, Raimund; Jöckel, Karl-Heinz; Hoffmann, Barbara

    2016-08-01

    Long-term exposure to fine particulate matter (PM2.5) may lead to increased blood pressure (BP). The role of industry- and traffic-specific PM2.5 remains unclear. We investigated the associations of residential long-term source-specific PM2.5 exposure with arterial BP and incident hypertension in the population-based Heinz Nixdorf Recall cohort study. We defined hypertension as systolic BP≥140mmHg, or diastolic BP≥90mmHg, or current use of BP lowering medication. Long-term concentrations of PM2.5 from all local sources (PM2.5ALL), local industry (PM2.5IND) and traffic (PM2.5TRA) were modeled with a dispersion and chemistry transport model (EURAD-CTM) with a 1km(2) resolution. We performed a cross-sectional analysis with BP and prevalent hypertension at baseline, using linear and logistic regression, respectively, and a longitudinal analysis with incident hypertension at 5-year follow-up, using Poisson regression with robust variance estimation. We adjusted for age, sex, body mass index, lifestyle, education, and major road proximity. Change in BP (mmHg), odds ratio (OR) and relative risk (RR) for hypertension were calculated per 1μg/m(3) of exposure concentration. PM2.5ALL was highly correlated with PM2.5IND (Spearman's ρ=0.92) and moderately with PM2.5TRA (ρ=0.42). In adjusted cross-sectional analysis with 4539 participants, we found positive associations of PM2.5ALL with systolic (0.42 [95%-CI: 0.03, 0.80]) and diastolic (0.25 [0.04, 0.46]) BP. Higher, but less precise estimates were found for PM2.5IND (systolic: 0.55 [-0.05, 1.14]; diastolic: 0.35 [0.03, 0.67]) and PM2.5TRA (systolic: 0.88 [-1.55, 3.31]; diastolic: 0.41 [-0.91, 1.73]). We found crude positive association of PM2.5TRA with prevalence (OR 1.41 [1.10, 1.80]) and incidence of hypertension (RR 1.38 [1.03, 1.85]), attenuating after adjustment (OR 1.19 [0.90, 1.58] and RR 1.28 [0.94, 1.72]). We found no association of PM2.5ALL and PM2.5IND with hypertension. Long-term exposures to all-source and

  13. Agriculture--Industry of the Future

    SciTech Connect

    2001-01-23

    This 8-page brochure describes the Office of Industrial Technologies' Agriculture Industry of the Future, a partnership between the Department of Energy and the agriculture industry established to increase industrial energy and cost efficiency.

  14. Establishment of a multimarker qPCR panel for the molecular characterization of circulating tumor cells in blood samples of metastatic breast cancer patients during the course of palliative treatment

    PubMed Central

    Bredemeier, Maren; Edimiris, Philippos; Tewes, Mitra; Mach, Pawel; Aktas, Bahriye; Schellbach, Doreen; Wagner, Jenny; Kimmig, Rainer; Kasimir-Bauer, Sabine

    2016-01-01

    Background Circulating tumor cells (CTC) are discussed to be an ideal surrogate marker for individualized treatment in metastatic breast cancer (MBC) since metastatic tissue is often difficult to obtain for repeated analysis. We established a nine gene qPCR panel to characterize the heterogeneous CTC population in MBC patients including epithelial CTC, their receptors (EPCAM, ERBB2, ERBB3, EGFR) CTC in Epithelial-Mesenchymal-Transition [(EMT); PIK3CA, AKT2), stem cell-like CTC (ALDH1) as well as resistant CTC (ERCC1, AURKA] to identify individual therapeutic targets. Results At TP0, at least one marker was detected in 84%, at TP1 in 74% and at TP2 in 79% of the patients, respectively. The expression of ERBB2, ERBB3 and ERCC1 alone or in combination with AURKA was significantly associated with therapy failure. ERBB2 + CTC were only detected in patients not receiving ERBB2 targeted therapies which correlated with no response. Furthermore, patients responding at TP2 had a significantly prolonged overall-survival than patients never responding (p = 0.0090). Patients and Methods 2 × 5 ml blood of 62 MBC patients was collected at the time of disease progression (TP0) and at two clinical staging time points (TP1 and TP2) after 8–12 weeks of chemo-, hormone or antibody therapy for the detection of CTC (AdnaTest EMT-2/StemCell Select™, QIAGEN Hannover GmbH, Germany). After pre-amplification, multiplex qPCR was performed. Establishment was performed using various cancer cell lines. PTPRC (Protein tyrosine phosphatase receptor type C) and GAPDH served as controls. Conclusions Monitoring MBC patients using a multimarker qPCR panel for the characterization of CTC might help to treat patients accordingly in the future. PMID:27223437

  15. Industry Study, Electronics Industry, Spring 2009

    DTIC Science & Technology

    2009-01-01

    environment. We will develop these observations, and others, in the course of this paper. We are first going to establish context for the industry ...Taiwanese IC industry illustrates the best example of a world class IC CVVI concept. Specifically, TSMC co- develops advanced-technology designs with their...technology node. Significant expenditures by industry and government are required to educate new intellectual talent, perform research and development

  16. Industrial alliances

    SciTech Connect

    Adams, K.V.

    1993-09-13

    The United States is emerging from the Cold War era into an exciting, but challenging future. Improving the economic competitiveness of our Nation is essential both for improving the quality of life in the United States and maintaining a strong national security. The research and technical skills used to maintain a leading edge in defense and energy now should be used to help meet the challenge of maintaining, regaining, and establishing US leadership in industrial technologies. Companies recognize that success in the world marketplace depends on products that are at the leading edge of technology, with competitive cost, quality, and performance. Los Alamos National Laboratory and its Industrial Partnership Center (IPC) has the strategic goal to make a strong contribution to the nation`s economic competitiveness by leveraging the government`s investment at the Laboratory: personnel, infrastructure, and technological expertise.

  17. Donating Blood

    MedlinePlus

    ... blood transfusion. Blood donors — especially donors with certain blood types — are always in demand. Who Can Donate Blood? ... Natural Disasters: How to Help Blood Blood Transfusions Blood Types Contact Us Print Resources Send to a Friend ...

  18. Lead levels - blood

    MedlinePlus

    Blood lead levels ... is used to screen people at risk for lead poisoning. This may include industrial workers and children ... also used to measure how well treatment for lead poisoning is working. Lead is common in the ...

  19. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Blood storage refrigerator and blood storage... Establishments That Manufacture Blood and Blood Products § 864.9700 Blood storage refrigerator and blood storage freezer. (a) Identification. A blood storage refrigerator and a blood storage freezer are devices...

  20. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Blood storage refrigerator and blood storage... Establishments That Manufacture Blood and Blood Products § 864.9700 Blood storage refrigerator and blood storage freezer. (a) Identification. A blood storage refrigerator and a blood storage freezer are devices...

  1. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Blood storage refrigerator and blood storage... Establishments That Manufacture Blood and Blood Products § 864.9700 Blood storage refrigerator and blood storage freezer. (a) Identification. A blood storage refrigerator and a blood storage freezer are devices...

  2. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Blood storage refrigerator and blood storage... Establishments That Manufacture Blood and Blood Products § 864.9700 Blood storage refrigerator and blood storage freezer. (a) Identification. A blood storage refrigerator and a blood storage freezer are devices...

  3. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Blood storage refrigerator and blood storage... Establishments That Manufacture Blood and Blood Products § 864.9700 Blood storage refrigerator and blood storage freezer. (a) Identification. A blood storage refrigerator and a blood storage freezer are devices...

  4. Impact of comprehensive cardiovascular risk reduction programme on risk factor clustering associated with elevated blood pressure in an Indian industrial population.

    PubMed

    Jeemon, Panniyammakal; Prabhakaran, Dorairaj; Goenka, Shifalika; Ramakrishnan, Lakshmy; Padmanabhan, Sandosh; Huffman, Mark; Joshi, Prashant; Sivasankaran, Sivasubramonian; Mohan, B V M; Ahmed, F; Ramanathan, Meera; Ahuja, R; Sinha, Nakul; Thankappan, K R; Reddy, K S

    2012-04-01

    Cardiovascular risk factors clustering associated with blood pressure (BP) has not been studied in the Indian population. This study was aimed at assessing the clustering effect of cardiovascular risk factors with suboptimal BP in Indian population as also the impact of risk reduction interventions. Data from 10543 individuals collected in a nation-wide surveillance programme in India were analysed. The burden of risk factors clustering with blood pressure and coronary heart disease (CHD) was assessed. The impact of a risk reduction programmme on risk factors clustering was prospectively studied in a sub-group. Mean age of participants was 40.9 ± 11.0 yr. A significant linear increase in number of risk factors with increasing blood pressure, irrespective of stratifying using different risk factor thresholds was observed. While hypertension occurred in isolation in 2.6 per cent of the total population, co-existence of hypertension and >3 risk factors was observed in 12.3 per cent population. A comprehensive risk reduction programme significantly reduced the mean number of additional risk factors in the intervention population across the blood pressure groups, while it continued to be high in the control arm without interventions (both within group and between group P<0.001). The proportion of 'low risk phenotype' increased from 13.4 to 19.9 per cent in the intervention population and it was decreased from 27.8 to 10.6 per cent in the control population (P<0.001). The proportion of individuals with hypertension and three more risk factors decreased from 10.6 to 4.7 per cent in the intervention arm while it was increased from 13.3 to 17.8 per cent in the control arm (P<0.001). Our findings showed that cardiovascular risk factors clustered together with elevated blood pressure and a risk reduction programme significantly reduced the risk factors burden.

  5. Impact of comprehensive cardiovascular risk reduction programme on risk factor clustering associated with elevated blood pressure in an Indian industrial population

    PubMed Central

    Jeemon, Panniyammakal; Prabhakaran, Dorairaj; Goenka, Shifalika; Ramakrishnan, Lakshmy; Padmanabhan, Sandosh; Huffman, Mark; Joshi, Prashant; Sivasankaran, Sivasubramonian; Mohan, B.V.M.; Ahmed, F.; Ramanathan, Meera; Ahuja, R.; Sinha, Nakul; Thankappan, K.R.; Reddy, K.S.

    2012-01-01

    Background & objectives: Cardiovascular risk factors clustering associated with blood pressure (BP) has not been studied in the Indian population. This study was aimed at assessing the clustering effect of cardiovascular risk factors with suboptimal BP in Indian population as also the impact of risk reduction interventions. Methods: Data from 10543 individuals collected in a nation-wide surveillance programme in India were analysed. The burden of risk factors clustering with blood pressure and coronary heart disease (CHD) was assessed. The impact of a risk reduction programmme on risk factors clustering was prospectively studied in a sub-group. Results: Mean age of participants was 40.9 ± 11.0 yr. A significant linear increase in number of risk factors with increasing blood pressure, irrespective of stratifying using different risk factor thresholds was observed. While hypertension occurred in isolation in 2.6 per cent of the total population, co-existence of hypertension and >3 risk factors was observed in 12.3 per cent population. A comprehensive risk reduction programme significantly reduced the mean number of additional risk factors in the intervention population across the blood pressure groups, while it continued to be high in the control arm without interventions (both within group and between group P<0.001). The proportion of ‘low risk phenotype’ increased from 13.4 to 19.9 per cent in the intervention population and it was decreased from 27.8 to 10.6 per cent in the control population (P<0.001). The proportion of individuals with hypertension and three more risk factors decreased from 10.6 to 4.7 per cent in the intervention arm while it was increased from 13.3 to 17.8 per cent in the control arm (P<0.001). Interpretation & conclusions: Our findings showed that cardiovascular risk factors clustered together with elevated blood pressure and a risk reduction programme significantly reduced the risk factors burden. PMID:22664495

  6. EPA's Industry Assistance Office.

    ERIC Educational Resources Information Center

    Ruggiero, Michael A.

    1979-01-01

    The EPA's Industry Assistance Office, established under the Toxic Substance Control Act to help manufacturers and processors of chemical substances and mixtures to comply with the Act, is described. (BB)

  7. Establishing maintenance performance indicators

    SciTech Connect

    Baca, B.

    1994-10-01

    Maintenance Performance Indicators (PI) specify where the maintenance department is and which direction it is going allowing for a quick and accurate assessment of the performance of the Maintenance Management Program (MMP). Establishing PI`s for the maintenance department will allow a measure of productivity and a means of feedback for methods improvement. Effective performance of the maintenance department directly effects plant profitability. Improvements in the quality and productivity of the maintenance work force will significantly reduce maintenance costs. The level of performance attained by the maintenance work force is usually guessed at. Guessing will not identify areas needing improvement or help to initiate a corrective action. Maintenance PI`s are required for maintenance departments whose goal is to control maintenance costs while increasing productivity. The application of basic statistical methods will allow a maintenance department to know where they are and which direction they are going. The data presented in this paper is a representation of indicators used in industry as well as developed indicators to establish a complete maintenance performance indicator program. The methodology used in developing this program can be used as a way to manage a cost effective maintenance management program.

  8. 77 FR 40068 - Draft Guidance for Industry: Recommendations for Donor Questioning, Deferral, Reentry, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... Questioning, Deferral, Reentry, and Product Management To Reduce the Risk of Transfusion-Transmitted Malaria...-Transmitted Malaria'' dated June 2012. The draft guidance document provides blood establishments that collect... malaria. This guidance replaces the draft guidance entitled ``Guidance for Industry: Recommendations...

  9. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2001-01-01

    An overview of the industrial diamond industry is provided. More than 90 percent of the industrial diamond consumed in the U.S. and the rest of the world is manufactured diamond. Ireland, Japan, Russia, and the U.S. produce 75 percent of the global industrial diamond output. In 2000, the U.S. was the largest market for industrial diamond. Industrial diamond applications, prices for industrial diamonds, imports and exports of industrial diamonds, the National Defense Stockpile of industrial diamonds, and the outlook for the industrial diamond market are discussed.

  10. 7 CFR 63.200 - NSIIC establishment and purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY IMPROVEMENT CENTER General Provisions National Sheep Industry Improvement Center § 63.200 NSIIC establishment and purpose. (a) There is hereby established a National Sheep Industry Improvement Center. The...

  11. 7 CFR 63.200 - NSIIC establishment and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY IMPROVEMENT CENTER General Provisions National Sheep Industry Improvement Center § 63.200 NSIIC establishment and purpose. (a) There is hereby established a National Sheep Industry Improvement Center. The...

  12. 7 CFR 63.200 - NSIIC establishment and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY IMPROVEMENT CENTER General Provisions National Sheep Industry Improvement Center § 63.200 NSIIC establishment and purpose. (a) There is hereby established a National Sheep Industry Improvement Center. The...

  13. 7 CFR 63.200 - NSIIC establishment and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY IMPROVEMENT CENTER General Provisions National Sheep Industry Improvement Center § 63.200 NSIIC establishment and purpose. (a) There is hereby established a National Sheep Industry Improvement Center. The purpose...

  14. 5 CFR 532.215 - Establishments included in regular appropriated fund surveys.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 50 or more employees in the prescribed industries within a survey area shall be included within the... relatively few establishments, surveys shall cover all establishments within the prescribed industry and size... establishment list drawn under statistical sampling procedures....

  15. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2001-01-01

    A general overview of the industrial garnet industry is provided. About 20 percent of global industrial garnet production takes place in the U.S. During 2000, an estimated 300 kt of industrial garnets were produced worldwide. The U.S. is the world's largest consumer of industrial garnet, consuming 56.9 kt in 2000.

  16. Blood Disorders

    MedlinePlus

    ... blood cells, white blood cells and platelets. Blood disorders affect one or more parts of the blood ... They can be acute or chronic. Many blood disorders are inherited. Other causes include other diseases, side ...

  17. Blood pressure

    MedlinePlus Videos and Cool Tools

    Normal blood pressure is important for proper blood flow to the body's organs and tissues. The force of the blood on the walls of the arteries is called blood pressure. Blood pressure is measured both as the heart ...

  18. Blood Disorders

    MedlinePlus

    ... Blood Clots) Blood clot in a deep vein. Hemophilia Blood does not clot properly. Hereditary Hemorrhagic Telangiectasia ( ... infants. Blood Disorders Homepage Venous Thromboembolism (Blood Clots) Hemophilia Hereditary Hemorrhagic Telangiectasia (HHT) Sickle Cell Disease Thalassemia ...

  19. Legal, financial, and public health consequences of HIV contamination of blood and blood products in the 1980s and 1990s.

    PubMed

    Weinberg, Peter D; Hounshell, Jennie; Sherman, Laurence A; Godwin, John; Ali, Shirin; Tomori, Cecilia; Bennett, Charles L

    2002-02-19

    Ensuring the safety of the blood supply connects politics and science. The business and service sectors share responsibility for the collection and processing of blood donations, and government agencies perform regulatory and surveillance roles. The onset of the AIDS epidemic has challenged the interface among these systems, leading to widespread fears about compromised safety of the blood supply. Because of public concern about blood-supply decisions made in the 1980s, developed countries in the 1990s established reimbursement programs for persons with transfusion-acquired viral infections from blood or blood products, adopted diagnostic tests and procedures that improved the safety of the blood supply, and held criminal judicial investigations of government officials and industry leaders accused of delaying implementation of potential blood-safety measures. In contrast, developing countries continue to struggle with blood-supply safety issues. This paper summarizes the current status of these safety concerns in developed countries, where viral transmission from contaminated blood or blood products is extremely rare, and in developing countries, where up to 10% of HIV infections result from transfusion of blood or blood products.

  20. Cost-effectiveness of self-management of blood pressure in hypertensive patients over 70 years with suboptimal control and established cardiovascular disease or additional cardiovascular risk diseases (TASMIN-SR).

    PubMed

    Penaloza-Ramos, Maria Cristina; Jowett, Sue; Mant, Jonathan; Schwartz, Claire; Bray, Emma P; Sayeed Haque, M; Richard Hobbs, F D; Little, Paul; Bryan, Stirling; Williams, Bryan; McManus, Richard J

    2016-06-01

    A previous economic analysis of self-management, that is, self-monitoring with self-titration of antihypertensive medication evaluated cost-effectiveness among patients with uncomplicated hypertension. This study considered cost-effectiveness of self-management in those with raised blood pressure plus diabetes, chronic kidney disease and/or previous cardiovascular disease. A Markov model-based economic evaluation was undertaken to estimate the long-term cost-effectiveness of self-management of blood pressure in a cohort of 70-year-old 'high risk' patients, compared with usual care. The model used the results of the TASMIN-SR trial. A cost-utility analysis was undertaken from a UK health and social care perspective, taking into account lifetime costs of treatment, cardiovascular events and quality adjusted life years. A subgroup analysis ran the model separately for men and women. Deterministic sensitivity analyses examined the effect of different time horizons and reduced effectiveness of self-management. Base-case results indicated that self-management was cost-effective compared with usual care, resulting in more quality adjusted life years (0.21) and cost savings (-£830) per patient. There was a 99% chance of the intervention being cost-effective at a willingness to pay threshold of £20,000 per quality adjusted life year gained. Similar results were found for separate cohorts of men and women. The results were robust to sensitivity analyses, provided that the blood pressure lowering effect of self-management was maintained for more than a year. Self-management of blood pressure in high-risk people with poorly controlled hypertension not only reduces blood pressure, compared with usual care, but also represents a cost-effective use of healthcare resources. © The European Society of Cardiology 2015.

  1. British Industrial Libraries Before 1939

    ERIC Educational Resources Information Center

    Marshall, Margaret R.

    1972-01-01

    British industrial firm libraries are traced from their beginnings till 1939, by which date they had spread to many branches of industry and had been recognized as an important part of the industrial and library worlds, thus establishing standard patterns of work. The origins and significance of Aslib are discussed. (27 references) (Author/NH)

  2. Moving East: how the transnational tobacco industry gained entry to the emerging markets of the former Soviet Union-part II: an overview of priorities and tactics used to establish a manufacturing presence.

    PubMed

    Gilmore, A B; McKee, M

    2004-06-01

    To explore how British American Tobacco (BAT), having established cigarette imports, responded to the opportunities for investment in cigarette manufacturing in the former Soviet Union (FSU). Analysis of documents held at the BAT archive in Guildford, UK. Considerable priority was attached to investing in the FSU. This led BAT to undertake a major organisational change and to intense competition to acquire assets. BAT used flawed economic arguments to persuade cash starved governments that its investment would reap economic rewards. It offered excise advice that disadvantaged governments while benefiting BAT, confused issues over pricing, and avoided competitive tendering. BAT targeted agriculture ministries, using its expertise in leaf production to differentiate itself from other potential investors. It subverted the principles of corporate social responsibility to promote itself as a business partner. BAT's task was made easier by the naivety of post-Soviet governments and by the international financial organisations' support for rapid economic reform. The latter permitted tobacco transnationals to penetrate markets before effective competitive tendering processes had been established, giving them the opportunity to minimise prices and establish monopolies. Many of the arguments employed when penetrating post-Soviet markets were highly misleading but governments lacked expertise to realise this. There is a need to build tobacco control capacity in transition economies, within and outside government, to ensure that governments are better informed of the true economic and health impacts of tobacco. Rapid transition from socialist to market economies without establishing regulatory institutional structures may be dangerous when investing companies use business practices that fall short of international standards.

  3. Moving East: how the transnational tobacco industry gained entry to the emerging markets of the former Soviet Union—part II: an overview of priorities and tactics used to establish a manufacturing presence

    PubMed Central

    Gilmore, A; McKee, M

    2004-01-01

    Objectives: To explore how British American Tobacco (BAT), having established cigarette imports, responded to the opportunities for investment in cigarette manufacturing in the former Soviet Union (FSU). Design: Analysis of documents held at the BAT archive in Guildford, UK. Results: Considerable priority was attached to investing in the FSU. This led BAT to undertake a major organisational change and to intense competition to acquire assets. BAT used flawed economic arguments to persuade cash starved governments that its investment would reap economic rewards. It offered excise advice that disadvantaged governments while benefiting BAT, confused issues over pricing, and avoided competitive tendering. BAT targeted agriculture ministries, using its expertise in leaf production to differentiate itself from other potential investors. It subverted the principles of corporate social responsibility to promote itself as a business partner. BAT's task was made easier by the naivety of post-Soviet governments and by the international financial organisations' support for rapid economic reform. The latter permitted tobacco transnationals to penetrate markets before effective competitive tendering processes had been established, giving them the opportunity to minimise prices and establish monopolies. Conclusions: Many of the arguments employed when penetrating post-Soviet markets were highly misleading but governments lacked expertise to realise this. There is a need to build tobacco control capacity in transition economies, within and outside government, to ensure that governments are better informed of the true economic and health impacts of tobacco. Rapid transition from socialist to market economies without establishing regulatory institutional structures may be dangerous when investing companies use business practices that fall short of international standards. PMID:15175532

  4. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2003-01-01

    Statistics on the production, consumption, cost, trade, and government stockpile of natural and synthetic industrial diamond are provided. The outlook for the industrial diamond market is also considered.

  5. Money for Blood and Markets for Blood.

    PubMed

    Derpmann, Simon; Quante, Michael

    2015-12-01

    Ontario's Bill 178 proposing a Voluntary Blood Donations Act declares the offer or acceptance of payment for the donation of blood a legal offence and makes it subject to penalty. The bill reinvigorates a fundamental debate about the ethical problems associated with the payment of money for blood. Scarcity of blood donors is a recurring problem in most health systems, and monetary remuneration of the willingness to donate blood is regularly discussed--and sometimes practiced--as a means to overcome scarcity in blood. However, making blood an object of economic exchange has long aroused ethical concerns that often refer to the specific meaning of blood. From the perspective of a modern understanding of money as a metric of economic value, the exchange of money for blood--shed or given--is seen as ethically troubling, because it appears to imply a commensurability of the value of human life and economic wealth. In this paper, we begin with a general taxonomy of the types of arguments that speak in favour or against compensating donors for giving blood. We then describe the context in which the discussion about payment for blood arises, and of the specific aims and concerns that are brought forward in this context. This is used to reconstruct the normative background that supports the rejection of payment for blood as it is envisaged in Bill 178 and the aims of the proposal. We then argue that while a payment indeed changes the nature of a blood donation in an ethically considerable way, we do not believe that decisive arguments against the monetary remuneration of blood donations can be substantiated, at least not independently of assuming specific societal circumstances. Thus it may be possible to establish a stable and safe blood supply through just gratification while at the same time taking strong provisions against social disconnection, injustice, exploitation or heteronomy.

  6. Neurosurgery and industry.

    PubMed

    Robertson, Jon H

    2008-12-01

    The primary purpose of the relationship between neurosurgery and industry must be to improve patient care and advance medical knowledge. This relationship is desirable and can be mutually beneficial. Strict adherence to established ethical and legal guidelines is necessary to avoid financial conflicts of interest that may occur between neurosurgery and industry. The Code of Ethics established by the American Association of Neurological Surgeons (AANS) in 1986 emphasizes the physician's responsibility to always act in the best interest of his or her patients. The AANS Guidelines for Corporate Relations were developed in 2004 to address the concern of the potential growing influence of industry in the activities of our neurosurgical organization. Recognizing a need to clarify the proper relationships between neurosurgeons and industry, Guidelines on Neurosurgeon-Industry Conflicts of Interest were recently established. The AANS is committed to the highest ethical and legal standards in future relations with our industry partners. Members of the AANS are encouraged to adhere to the voluntary guidelines established by our organization.

  7. Industrial Minerals

    ERIC Educational Resources Information Center

    Bradbury, James C.

    1978-01-01

    The past year is seen as not particularly good for industrial minerals and for industry in general. Environmental concerns continued to trouble the industry with unacceptable asbestos concentrations and chlorofluorocarbon effects on ozone. A halting U.S. economy also affected industrial progress. (MA)

  8. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2000-01-01

    Part of the 1999 Industrial Minerals Review. A review of the state of the global industrial diamond industry in 1999 is presented. World consumption of industrial diamond has increased annually in recent years, with an estimated 500 million carats valued between $650 million and $800 million consumed in 1999. In 1999, the U.S. was the world's largest market for industrial diamond and was also one of the world's main producers; the others were Ireland, Russia, and South Africa. Uses of industrial diamonds are discussed, and prices of natural and synthetic industrial diamond are reported.

  9. Applying industrial symbiosis to chemical industry: A literature review

    NASA Astrophysics Data System (ADS)

    Cui, Hua; Liu, Changhao

    2017-08-01

    Chemical industry plays an important role in promoting the development of global economy and human society. However, the negative effects caused by chemical production cannot be ignored, which often leads to serious resource consumption and environmental pollution. It is essential for chemical industry to achieve a sustainable development. Industrial symbiosis is one of the key topics in the field of industrial ecology and circular economy, which has been identified as a creative path leading to sustainability. Based on an extensively searching for literatures on linking industrial symbiosis with chemical industry, this paper aims to review the literatures which involves three aspects: (1) economic and environmental benefits achieved by chemical industry through implementing industrial symbiosis, (2) chemical eco-industrial parks, (3) and safety issues for chemical industry. An outlook is also provided. This paper concludes that: (1) chemical industry can achieve both economic and environmental benefits by implementing industrial symbiosis, (2) establishing eco-industrial parks is essential for chemical industry to implement and improve industrial symbiosis, and (3) there is a close relationship between IS and safety issues of chemical industry.

  10. Blood transfusion in obstetrics.

    PubMed

    Nigam, A; Prakash, A; Saxena, P

    2013-01-01

    Transfusion of blood and blood components is a common practice in obstetric wards but it is not without risk. The incidence of transfusion reactions varies from 4 in every hundred transfusions for non-haemolytic reactions to one in every 40,000 for haemolytic transfusion reactions. The physiological basis of blood transfusion is outlined in this article. Most of the donated blood is processed into components: packed red cells (PRBCs), platelets, and fresh frozen plasma (FFP) or cryoprecipitate. Various alternatives to blood transfusion exist and include autotransfusion, pre-autologous blood storage, use of oxygen carrying blood substitutes and intraoperative cell salvage. Despite the risks associated with transfusions, obstetricians are frequently too aggressive in transfusing blood and blood products to their patients. Acute blood loss in obstetrics is usually due to placenta praevia, postpartum blood loss and surgery related. An early involvement of a consultant obstetrician, anaesthetist, haematologist and the blood bank is essential. There are no established criteria for initiating red cell transfusions and the decision is purely based on clinical and haematological parameters, which have been discussed along with the general principles of blood transfusion in obstetrics and some practical guidelines.

  11. Use of agro-industrial organic sludge amendment to remediate degraded soil: chemical and eco(geno)toxicological differences between fresh and stabilized sludge and establishment of application rates.

    PubMed

    Chiochetta, Claudete G; Cotelle, Sylvie; Masfaraud, Jean-François; Toumi, Hela; Quaranta, Gaetana; Adani, Fabrizio; Radetski, Claudemir M

    2016-02-01

    Soil degraded by coal mining activities can be remediated by amendment with agro-industrial organic sludge. However, the environmental impacts associated with this management practice must be properly addressed. In this context, the objective of this study was to evaluate the eco(geno)toxicity of a fresh and a stabilized sludge before use in a laboratory soil remediation test. Chemical analysis of the complex mixtures (degraded soil, fresh sludge, and stabilized sludge) was carried out, as well as a battery of eco(geno)toxicity tests on microbiological enzymes (fluorescein hydrolysis), earthworms, and higher plants (including Vicia faba genotoxicity test), according to published methodologies. The results of these tests showed that fresh sludge was more toxic than sludge stabilized over 6 months toward earthworms and higher plants (lettuce, corn, and wild cabbage), while phyto(geno)toxicity tests with V. faba indicated the same genotoxicity levels for the two types of sludge. In the soil remediation simulation using different mixtures of degraded soil and stabilized sludge, the proportions of 50:50% (dry weight basis) provided the lowest phyto(geno)toxicity effects and this mixture can be used for the revegetation of the contaminated site.

  12. Blood clotting

    MedlinePlus Videos and Cool Tools

    ... the external bleeding stops. Clotting factors in the blood cause strands of blood-borne material, called fibrin, to stick together and ... the inside of the wound. Eventually, the cut blood vessel heals, and the blood clot dissolves after ...

  13. Blood typing

    MedlinePlus

    A blood sample is needed. The test to determine your blood group is called ABO typing. Your blood sample is mixed with antibodies against type A and B blood. Then, the sample is checked to see whether ...

  14. Blood culture

    MedlinePlus

    Culture - blood ... A blood sample is needed . The site where blood will be drawn is first cleaned with an antiseptic such ... organism from the skin getting into (contaminating) the blood sample and causing a false-positive result (see ...

  15. Blood transfusions

    MedlinePlus

    ... this page: //medlineplus.gov/ency/patientinstructions/000431.htm Blood transfusions To use the sharing features on this ... several sources of blood which are described below. Blood From the Public (Volunteer Blood Donation) The most ...

  16. Blood Types

    MedlinePlus

    ... FIND A BLOOD DRIVE Blood Types and the Population O positive is the most common blood type. ... of the different blood types in the U.S. population is: Caucasian African- American Latino-American Asian O + ...

  17. Industrial applications of nanoparticles.

    PubMed

    Stark, W J; Stoessel, P R; Wohlleben, W; Hafner, A

    2015-08-21

    Research efforts in the past two decades have resulted in thousands of potential application areas for nanoparticles - which materials have become industrially relevant? Where are sustainable applications of nanoparticles replacing traditional processing and materials? This tutorial review starts with a brief analysis on what makes nanoparticles attractive to chemical product design. The article highlights established industrial applications of nanoparticles and then moves to rapidly emerging applications in the chemical industry and discusses future research directions. Contributions from large companies, academia and high-tech start-ups are used to elucidate where academic nanoparticle research has revolutionized industry practice. A nanomaterial-focused analysis discusses new trends, such as particles with an identity, and the influence of modern instrument advances in the development of novel industrial products.

  18. Monitoring the HTLV-1 proviral load in the peripheral blood of asymptomatic carriers and patients with HTLV-associated myelopathy/tropical spastic paraparesis from a Brazilian cohort: ROC curve analysis to establish the threshold for risk disease.

    PubMed

    Furtado, Marina dos Santos Brito Silva; Andrade, Rafaela Gomes; Romanelli, Luiz Cláudio Ferreira; Ribeiro, Maisa Aparecida; Ribas, João Gabriel; Torres, Elídio Barbosa; Barbosa-Stancioli, Edel Figueiredo; Proietti, Anna Bárbara de Freitas Carneiro; Martins, Marina Lobato

    2012-04-01

    Human T-lymphotropic virus 1 (HTLV-1) infection is associated with HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which affects approximately 5% of carriers. High proviral load is a risk marker for HAM/TSP, although there is an overlap of proviral load levels in peripheral blood between asymptomatic carriers and HAM/TSP patients. In this study, receiver operating characteristic curve analysis was used to define a set point of HTLV-1 proviral load that better indicates an increased risk for HAM/TSP. Proviral load was quantified in 75 asymptomatic carriers and 78 HAM/TSP patients in a Brazilian cohort. The cut-off of proviral load was defined as 114 copies/10(4)  cells, with 78.2% sensitivity to identify true HAM/TSP patients. The mean proviral load levels were not significantly different between males and females with the same clinical status, and there was no significant correlation between proviral load and age at blood sampling, age at the onset of illness, or duration of disease. In HAM/TSP patients, proviral load was significantly higher in wheelchair-bound patients than in individuals able to walk without support and in those with the worst spinal cord injuries. Follow-up of HTLV-1-infected individuals showed that proviral load was more stable in asymptomatic carriers than in HAM/TSP patients. In a cohort study, periodically quantifying proviral load in asymptomatic carriers is necessary to identify those at risk for developing neurological disease, and it is necessary for HAM/TSP patients to monitor spinal injury and progression to walking disability. The measure of proviral load in clinical practice implicates the definition of the cut-off of proviral load and its validation during follow-up. Copyright © 2012 Wiley Periodicals, Inc.

  19. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2004-01-01

    Part of the 2003 industrial minerals review. Supply and demand data for industrial diamond are provided. Topics discussed are consumption, prices, imports and exports, government stockpiles, and the outlook for 2004.

  20. Industrial hygiene forum

    SciTech Connect

    Banks, O.M.; Hoiem, K.H.

    1987-01-01

    On routine blood tests, two employees of a hospital Dental Service unit had elevated mercury levels. On 23 June 1986, an industrial hygienist made a mercury vapor survey of the area with the use of Jerome direct reading mercury vapor meter and collection on mercury vapor sampling tubes for laboratory analysis by flameless atomic absorption. No work practices were observed that would account for the elevated mercury levels in the blood. All airborne mercury levels were well below detectable limits. A box of Monoject purple top blood collection tubes used for collection of blood for mercury determination was examined. The box listed sodium ethylmercurithiosalicylate as the antimicrobial agent additive. The use of a mercurial preservative on samples for mercury determinations seemed totally inappropriate. Mercury vapor measurements that were made inside these tubes clearly indicated the presence of mercury.

  1. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2012-01-01

    Estimated 2011 world production of natural and synthetic industrial diamond was about 4.45 billion carats. During 2011, natural industrial diamonds were produced in more than 20 countries, and synthetic industrial diamond was produced in at least 13 countries. About 98 percent of the combined natural and synthetic global output was produced in China, Ireland, Japan, Russia, South Africa and the United States. China is the world's leading producer of synthetic industrial diamond followed by Russia and the United States.

  2. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2011-01-01

    Estimated world production of natural and synthetic industrial diamond was about 4.44 billion carats in 2010. Natural industrial diamond deposits have been found in more than 35 countries, and synthetic industrial diamond is produced in at least 15 countries.

  3. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2006-01-01

    In 2005, estimated world production of natural and synthetic industrial diamond was 630 million carats. Natural industrial diamond deposits were found in more than 35 countries. Synthetic industrial diamond is produced in at least 15 countries. More than 81% of the combined natural and synthetic global output was produced in Ireland, Japan, Russia, South Africa and the United States.

  4. Industrial Microbiology.

    ERIC Educational Resources Information Center

    Demain, Arnold L.; Solomon, Nadine A.

    1981-01-01

    Presents an overview of the field of industrial microbiology, providing historical backgrounds of scientific discoveries in the field and descriptions of industrially important microorganisms. Applied research in industry is also detailed, with mention of gene amplification, DNA recombination, pharmaceutical approaches, and detoxification and…

  5. Industrial Microbiology.

    ERIC Educational Resources Information Center

    Demain, Arnold L.; Solomon, Nadine A.

    1981-01-01

    Presents an overview of the field of industrial microbiology, providing historical backgrounds of scientific discoveries in the field and descriptions of industrially important microorganisms. Applied research in industry is also detailed, with mention of gene amplification, DNA recombination, pharmaceutical approaches, and detoxification and…

  6. Pharmacist-industry relationships.

    PubMed

    Saavedra, Keene; O'Connor, Bonnie; Fugh-Berman, Adriane

    2017-01-18

    The purpose of this study was to document, in their own words, beliefs and attitudes that American pharmacists have towards the pharmaceutical industry and pharmacists' interactions with industry. An ethnographic-style qualitative study was conducted utilizing open-ended interviews with four hospital pharmacists, two independent pharmacists, two retail pharmacists and one administrative pharmacist in the Washington, DC, metropolitan area to elicit descriptions of and attitudes towards pharmacists' relationships with industry. Analysis of the qualitative material followed established ethnographic conventions of narrative thematic analysis. All pharmacists reported interactions with pharmaceutical company representatives. Most had received free resources or services from industry, including educational courses. Respondents uniformly believed that industry promotional efforts are primarily directed towards physicians. Although respondents felt strongly that drug prices were excessive and that 'me-too' drugs were of limited use, they generally had a neutral-to-positive view of industry-funded adherence/compliance programmes, coupons, vouchers, and copay payment programmes. Interviewees viewed direct-to-consumer advertising negatively, but had a generally positive view of industry-funded drug information. Pharmacists may represent a hitherto under-identified cohort of health professionals who are targeted for industry influence; expanding roles for pharmacists may make them even more attractive targets for future industry attention. Pharmacy schools should ensure that students learn to rely on unbiased information sources and should teach students about conflicts of interest and the risks of interacting with industry. Further research should be conducted on the extent to which pharmacists' attitudes towards their duties and towards drug assessment and recommendation are influenced by the pharmaceutical industry. © 2017 Royal Pharmaceutical Society.

  7. Donating Blood

    MedlinePlus

    ... can't get an infection or disease from giving blood. The needles and other equipment used are sterile ... part of blood (plasma) within 72 hours after giving blood. It generally takes about 4–8 weeks to ...

  8. Blood Sugar

    MedlinePlus

    Blood sugar, or glucose, is the main sugar found in your blood. It comes from the food you eat, and is your body's main source of energy. Your blood carries glucose to all of your body's cells to use ...

  9. Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions.

    PubMed

    Isoda, Miho; Kohyama, Jun; Iwanami, Akio; Sanosaka, Tsukasa; Sugai, Keiko; Yamaguchi, Ryo; Matsumoto, Takuya; Nakamura, Masaya; Okano, Hideyuki

    2016-09-01

    Neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) are expected to be a valuable cell source for cell therapies that target central nervous system disorders. For clinical applications, NS/PCs should be induced and maintained under clinical grade conditions, which are challenging to achieve. In the present study, we established a procedure to obtain xeno-free long-term self-renewing neuroepithelial-like stem cells (xf-lt-NES cells) from feeder-free hiPSCs using a newly developed xeno-free medium, StemFit(®)AS200. xf-lt-NES cells were cultured for long periods in StemFit(®)AS200 while retaining normal karyotypes, NS/PC marker expression and differentiation capacity for neuronal and glial differentiation in vitro and in vivo. Furthermore, the cells were cryopreserved using a defined serum-free freezing reagent, which demonstrated the feasibility of this xeno-free culture system for large-scale lt-NES cell production and cell banking. Taken together, our system represents a promising approach for the manufacture of clinically relevant products for cell therapy using NS/PCs.

  10. [Quality Control in Umbilical Cord Blood Bank

    PubMed

    Zhou, Sheng-Li; Song, Dao-Gang; Shen, Bai-Jun; Pan, Jie

    2001-03-01

    Recent clinical reports have demonstrated that the use of umbilical cord blood (UCB) opened a new source of stem cell for hematopoietic stem cell transplantation, leading to the development of cord blood banks world-wide. Prior to the large scale construction of UCB banks, quality control must be performed for health care providers and manufactures. With increasingly stringent regulatory requirement in blood industry, quality control is playing an important role in the operation of blood centers and stem cell laboratories. Reviewed the lectures in the biology of UCB and UCB banks published in recent years, our experiences were discussed in setting up Shandong blood bank to define process variables associated with the collection of UCB, to determine and optimize the procedures and materials used, to ascertain how UCB can be processed in clean room as mononucleated cell preparations, and to analyze using of long-term storage of UCB in research and clinic in the future. Our conclusions are: (1) the establishment of UCB banks for use in transplantation appears to be easy, effective and particularly suitable approach in China under cGMP conditions; (2) the procedures for volume reduction by closed and semi-automated blood processing system, SSP HLA typing, biocode and local computer net, microbiological tests and the 50 ml cryobags for storage constitute a cost efficient system for large-scale UCB banking; (3) the average of 60 ml UCB collection may contain sufficent marrow repopulating cells for children and most of adult recipients; and (4) hematopoietic stem and progenitor cells in cord blood have a more potent proliferative ability than those derived from bone marrow in cell expansion potentials.

  11. Maintaining the Defense Industrial Base

    DTIC Science & Technology

    1994-05-02

    34 43 Utilizing concurrent engineering , development times are reduced by up to 40%.44 Japan’s auto industry use of concurrent engineering is a factor in... Developing this prescription for maintaining the defense industrial base involves a two step process. First, it is important to establish the current...increased. The skills required to work with advanced aerospace composite materials are unique to the industry . Developing 8 -1777 profiiency in this

  12. Industry Invests in Research Centers.

    ERIC Educational Resources Information Center

    Ploch, Margie

    1983-01-01

    Universities and industry are forging new relationships to support academic research and industrial research and development, including the establishment of university/cooperative research centers. Discusses various cooperative projects at these research centers. Includes a list of representative R&D centers in biotechnology, building…

  13. Industry Invests in Research Centers.

    ERIC Educational Resources Information Center

    Ploch, Margie

    1983-01-01

    Universities and industry are forging new relationships to support academic research and industrial research and development, including the establishment of university/cooperative research centers. Discusses various cooperative projects at these research centers. Includes a list of representative R&D centers in biotechnology, building…

  14. The Protestant Establishment Revisited

    ERIC Educational Resources Information Center

    Baltzell, E. Digby

    1976-01-01

    The author's book, "The Protestant Establishment: Aristocracy and Caste in America", is highly critical of the WASP (White-Anglo-Saxon-Protestant) establishment and proposed the development and need for some sort of upper-class ruling-group. Here is a re-evaluation of his book, now thirteen years old, by the author. (Author/RK)

  15. The Protestant Establishment Revisited

    ERIC Educational Resources Information Center

    Baltzell, E. Digby

    1976-01-01

    The author's book, "The Protestant Establishment: Aristocracy and Caste in America", is highly critical of the WASP (White-Anglo-Saxon-Protestant) establishment and proposed the development and need for some sort of upper-class ruling-group. Here is a re-evaluation of his book, now thirteen years old, by the author. (Author/RK)

  16. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  17. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  18. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  19. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  20. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  1. What's Blood?

    MedlinePlus

    ... Let's find out more about each ingredient. continue Red Blood Cells Red blood cells (also called erythrocytes, say: ih-RITH-ruh-sytes) ... Most of the cells in the blood are red blood cells. They carry around an important chemical called hemoglobin ( ...

  2. Photonic non-contact estimation of blood lactate level.

    PubMed

    Abraham, Chen; Beiderman, Yevgeny; Ozana, Nisan; Tenner, Felix; Schmidt, Michael; Sanz, Martin; Garcia, Javier; Zalevsky, Zeev

    2015-10-01

    The ability to measure the blood lactate level in a non-invasive, non-contact manner is very appealing to the sports industry as well as the home care field. That is mainly because this substance level is an imperative parameter in the course of devolving a personal workout programs. Moreover, the blood lactate level is also a pivotal means in estimation of muscles' performance capability. In this manuscript we propose an optical non-contact approach to estimate the concentration level of this parameter. Firstly, we introduce the connection between the physiological muscle tremor and the lactate blood levels. Secondly, we suggest a photonic optical method to estimate the physiological tremor. Lastly, we present the results of tests conducted to establish proof of concept to this connection.

  3. Photonic non-contact estimation of blood lactate level

    PubMed Central

    Abraham, Chen; Beiderman, Yevgeny; Ozana, Nisan; Tenner, Felix; Schmidt, Michael; Sanz, Martin; Garcia, Javier; Zalevsky, Zeev

    2015-01-01

    The ability to measure the blood lactate level in a non-invasive, non-contact manner is very appealing to the sports industry as well as the home care field. That is mainly because this substance level is an imperative parameter in the course of devolving a personal workout programs. Moreover, the blood lactate level is also a pivotal means in estimation of muscles' performance capability. In this manuscript we propose an optical non-contact approach to estimate the concentration level of this parameter. Firstly, we introduce the connection between the physiological muscle tremor and the lactate blood levels. Secondly, we suggest a photonic optical method to estimate the physiological tremor. Lastly, we present the results of tests conducted to establish proof of concept to this connection. PMID:26504661

  4. Industrial Robots.

    ERIC Educational Resources Information Center

    Reed, Dean; Harden, Thomas K.

    Robots are mechanical devices that can be programmed to perform some task of manipulation or locomotion under automatic control. This paper discusses: (1) early developments of the robotics industry in the United States; (2) the present structure of the industry; (3) noneconomic factors related to the use of robots; (4) labor considerations…

  5. Industrial Communications.

    ERIC Educational Resources Information Center

    Lindsay, Dan

    Intended for seniors planning a career in industry as skilled laborers, this specialized course in Industrial Communications offers the student basic communications skills which he will need in his work and in his daily life. Since class activities center around short, factual oral reports, class size will be limited to 20, providing a maximum of…

  6. INDUSTRIAL SKILLS.

    ERIC Educational Resources Information Center

    SEYMOUR, W. DOUGLAS

    THIS BOOK, A SEQUEL TO THE AUTHOR'S "INDUSTRIAL TRAINING FOR MANUAL OPERATIONS," COMPRISES THREE PARTS. IN PART ONE, THE NATURE OF SKILLS IN INDUSTRY IS DESCRIBED, AND THEIR RELATION TO HUMAN PERFORMANCE AND PRODUCTIVITY. IN PART TWO, AN OUTLINE OF RECENT RESEARCH AND A RESUME OF THE STATE OF KNOWLEDGE OF THE ACQUISITION OF SKILLS IS GIVEN. IN…

  7. Industrial Minerals.

    ERIC Educational Resources Information Center

    Brady, Lawrence L.

    1983-01-01

    Discusses trends in and factors related to the production of industrial minerals during 1982, indicating that, as 1981 marked a downturn in production of industrial minerals, 1982 continued the trend with temporary and permanent cutbacks in mine and plant production. Includes highlights of several conferences/conference papers in this field.…

  8. Industrial Robots.

    ERIC Educational Resources Information Center

    Reed, Dean; Harden, Thomas K.

    Robots are mechanical devices that can be programmed to perform some task of manipulation or locomotion under automatic control. This paper discusses: (1) early developments of the robotics industry in the United States; (2) the present structure of the industry; (3) noneconomic factors related to the use of robots; (4) labor considerations…

  9. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2000-01-01

    The state of the global industrial garnet industry in 1999 is discussed. Industrial garnet mined in the U.S., which accounts for approximately one-third of the world's total, is usually a solid-solution of almandine and pyrope. The U.S. is the largest consumer of industrial garnet, using an estimated 47,800 st in 1999 as an abrasive and as a filtration medium in the petroleum industry, filtration plants, aircraft and motor vehicle manufacture, shipbuilding, wood furniture finishing operations, electronic component manufacture, ceramics manufacture, and glass production. Prices for crude concentrates ranged from approximately $50 to $110/st and refined garnet from $50 to $215/st in 1999, depending on type, source, quantity purchased, quality, and application.

  10. RLS and blood donation.

    PubMed

    Burchell, Brendan J; Allen, Richard P; Miller, Jessica K; Hening, Wayne A; Earley, Christopher J

    2009-09-01

    The link between brain iron deficiency and RLS is now well established. In a related observation, several conditions that can deplete iron stores have been linked to increased probability of RLS. Blood donation has been linked to iron deficiency. It has thus been hypothesized that donating blood may be a risk factor for developing RLS. Two thousand and five UK blood donors, ranging from first-time donors to some who had donated more than 70 times, completed the validated Cambridge-Hopkins RLS questionnaire (CH-RLSq) following their donation session. The questionnaire included a set of questions designed to diagnose RLS. The donors' histories of blood donations were determined both from self-report and from the National Blood Service database. A number of statistical models were constructed to determine whether the probability of RLS diagnosis was related to the history of blood donations. Controlling for age and sex, no evidence was found to suggest that a greater number or frequency of blood donations increased the risk of RLS. Even amongst sub-groups especially vulnerable to iron depletion through blood donation, such as vegetarians or low weight individuals, no evidence for an increased risk of RLS could be found. We found no evidence that the frequency or number of blood donations up to the UK maximum of three times a year would increase the risk of RLS.

  11. INDUSTRIAL ASSESSMENT CENTER PROGRAM

    SciTech Connect

    ASFAW BEYENE

    2008-09-29

    Since its establishment in 1990, San Diego State University’s Industrial Assessment Center (IAC) has served close to 400 small and medium-sized manufacturing plants in Southern California. SDSU/IAC’s efforts to transfer state-of-the-art technologies to industry have increased revenues, cultivated creativity, improved efficiencies, and benefited the environment. A substantial benefit from the program has been the ongoing training of engineering faculty and students. During this funding cycle, SDSU/IAC has trained 31 students, 7 of the graduate. A total of 92 assessments and 108 assessment days were completed, resulting in 638 assessment recommendations.

  12. Water requirements of selected industries

    USGS Publications Warehouse

    ,; Mussey, Orville D.; Conklin, Howard L.; Durfor, Charles N.; Otts, Louis Ethelbert; Walling, Faulkner B.

    1955-01-01

    The early industries in America generally were established when and where demands for the products of industry arose. Most of the early industries were so located that their increasing requirements for transportation, raw materials, market, labor, and water supply could be satisfied economically. Many of these original plant locations have continued as modern industrial centers and their output has increased manyfold in meeting the demands of our growing Nation. The recent and current industrial expansion and the trend toward the growth of chemical industries, many Of which are heavy users of water, has resulted in a tremendous increase in the total withdrawal of water for industrial use as well as a large increase in the per capita use of water. This increase in industrial water requirement has strained the capacity of the developed water supplies in many areas, and in some instances the adequacy of the potential water supplies is questionable. The Geological Survey is engaged in preparing and publishing a series of reports describing the developed and undeveloped water resources of many important industrial areas. This work was started initially at the request of the National Securities Resources Board as a means to insure that water supplies are adequate for our rapidly expanding industrial development. Although many factors contribute to establishing the feasibility or even the limits of future industrial development, the one relating to available water supply is extremely important. A knowledge of the water requirements of various industries is valuable therefore in planning the logical development in any area where water supply is a critical factor. Thus far very little suitable information on the water requirements of our major industries is available for general planning. An inventory of unit water-use values in industry therefore would be generally helpful and also might tend to stimulate water-conservation methods. To obtain such information

  13. 29 CFR 779.354 - Who may qualify as exempt 13(a)(2) or 13(a)(4) establishments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for resale and are recognized as retail sales of goods or services in the industry. These requirements... establishment is recognized as a retail establishment in the industry (see § 779.347 and paragraph (c) of this...). (c) Establishments recognized as retail in the industry. An establishment which meets the...

  14. Artificial blood.

    PubMed

    Sarkar, Suman

    2008-07-01

    Artificial blood is a product made to act as a substitute for red blood cells. While true blood serves many different functions, artificial blood is designed for the sole purpose of transporting oxygen and carbon dioxide throughout the body. Depending on the type of artificial blood, it can be produced in different ways using synthetic production, chemical isolation, or recombinant biochemical technology. Development of the first blood substitutes dates back to the early 1600s, and the search for the ideal blood substitute continues. Various manufacturers have products in clinical trials; however, no truly safe and effective artificial blood product is currently marketed. It is anticipated that when an artificial blood product is available, it will have annual sales of over $7.6 billion in the United States alone.

  15. A changing time: the International Society for Cellular Therapy embraces its industry members.

    PubMed

    Deans, Robert; Gunter, Kurt C; Allsopp, Timothy; Bonyhadi, Mark; Burger, Scott R; Carpenter, Melissa; Clark, Tara; Cox, Charles S; Driscoll, Dawn; Field, Ed; Huss, Ralf; Lardenoije, René; Lodie, Tracey A; Mason, Chris; Neubiser, Richard; Rasko, John E J; Rowley, Jon; Maziarz, Richard T

    2010-11-01

    The last decade has seen a dramatic rise in the development of new cellular therapeutics in a wide range of indications. There have been acceptable safety profiles reported in early studies using blood-derived and adherent stem cell products, but also an inconsistent efficacy record. Further expansion has been hindered in part by a lack of capital (both private and public) and delayed entry into the cell therapy space by large healthcare and pharmaceutical companies, those members of the industry most reliably able to initiate and maintain advanced-phase clinical trials. With recognition that the International Society for Cellular Therapy (ISCT) is uniquely positioned to serve the global translational regenerative medicine research community as a network hub for scientific standards and policy, the ISCT commissioned the establishment of an Industry Task Force (ITF) to address current and future roles for industry. The objectives of the ITF were to gather information and prioritize efforts for a new Commercialization Committee (CC) and to construct innovative platforms that would foster constructive and synergistic collaborations between industry and ISCT. Recommendations and conclusions of the ITF included that the new CC: (1) foster new relationships with therapeutic and stem cell societies, (2) foster educational workshops and forums to cross-educate and standardize practices, (3) create industry subcommittees to address priority initiatives, with clear benchmarks and global implementation, and (4) establish a framework for a greater industry community within ISCT, opening doors for industry to share the new vision for commercialization of cell therapy, emphasizing the regenerative medicine space.

  16. Industrial Chemistry.

    ERIC Educational Resources Information Center

    Gumprecht, Donald L.; Thrasher, Joseph S.

    1990-01-01

    Described is a course designed to better prepare students for employment in chemical industries. A course schedule for this interim course and a list of sources of speakers and speaker credentials is provided. (CW)

  17. Blood Basics

    MedlinePlus

    ... woman has about nine pints. Jump To: The Components of Blood and Their Importance Many people have ... and treatment. back to top Plasma The liquid component of blood is called plasma, a mixture of ...

  18. Blood Clots

    MedlinePlus

    ... or prevent blood clots from dissolving properly. Risk factors for excessive blood clotting include Certain genetic disorders Atherosclerosis Diabetes Atrial fibrillation Overweight, obesity, and metabolic syndrome Some medicines Smoking deep vein ...

  19. Blood Types

    MedlinePlus

    ... the wrong blood type, the antibodies immediately set out to destroy the invading cells. This aggressive, whole-body response can give someone a fever, chills, and low blood pressure. It can even lead ...

  20. Blood Typing

    MedlinePlus

    ... this page helpful? Also known as: Blood Group; Rh Factor Formal name: ABO Group and Rh Type Related ... mother's and baby's ABO blood groups, not the Rh factor. However, ABO grouping cannot be used to predict ...

  1. Blood Donation

    MedlinePlus

    ... as A, B, AB or O — and your Rh factor. The Rh factor refers to the presence or absence of a ... information is important because your blood type and Rh factor must be compatible with the blood type and ...

  2. Electronics Industry

    DTIC Science & Technology

    2006-01-01

    companies to begin listing stock options as expenses on financial reports (Chappell, 2005). The industry had used stock options extensively to help... stock options (Chappell, 2005). Industry representatives interviewed by the group argued against the requirement since they predict U.S. companies...may be less inclined now to offer stock options , and subsequently talent may be lost to aggressive foreign competition (Anonymous interviews, 2006

  3. Blood Conservation.

    PubMed

    Martin, Jeremiah T; Ferraris, Victor A

    2015-01-01

    Patient blood management requires multi-modality and multidisciplinary collaboration to identify patients who are at increased risk of requiring blood transfusion and therefore decrease exposure to blood products. Transfusion is associated with poor postoperative outcomes, and guidelines exist to minimize transfusion requirements. This review highlights recent studies and efforts to apply patient blood management across disease processes and health care systems. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. 21 CFR 864.9100 - Empty container for the collection and processing of blood and blood components.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of blood and blood components. 864.9100 Section 864.9100 Food and Drugs FOOD AND DRUG ADMINISTRATION... Used In Establishments That Manufacture Blood and Blood Products § 864.9100 Empty container for the collection and processing of blood and blood components. (a) Identification. An empty container for...

  5. 21 CFR 864.9100 - Empty container for the collection and processing of blood and blood components.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of blood and blood components. 864.9100 Section 864.9100 Food and Drugs FOOD AND DRUG ADMINISTRATION... Used In Establishments That Manufacture Blood and Blood Products § 864.9100 Empty container for the collection and processing of blood and blood components. (a) Identification. An empty container for...

  6. 21 CFR 864.9100 - Empty container for the collection and processing of blood and blood components.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of blood and blood components. 864.9100 Section 864.9100 Food and Drugs FOOD AND DRUG ADMINISTRATION... Used In Establishments That Manufacture Blood and Blood Products § 864.9100 Empty container for the collection and processing of blood and blood components. (a) Identification. An empty container for...

  7. 21 CFR 864.9100 - Empty container for the collection and processing of blood and blood components.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of blood and blood components. 864.9100 Section 864.9100 Food and Drugs FOOD AND DRUG ADMINISTRATION... Used In Establishments That Manufacture Blood and Blood Products § 864.9100 Empty container for the collection and processing of blood and blood components. (a) Identification. An empty container for...

  8. Establishing a University Foundation.

    ERIC Educational Resources Information Center

    Lemish, Donald L.

    A handbook on how to establish a university foundation is presented. It presupposes that a foundation will be used as the umbrella organization for receiving all private gifts, restricted and unrestricted, for the benefit of a public college or university; and hence it chiefly addresses readers from public colleges and universities. Information is…

  9. Establishing a Continuous Repertoire.

    ERIC Educational Resources Information Center

    Meadowcroft, Pamela; Holland, James G.

    Investigators in this study looked for conditions that can rapidly establish continuous stimulus control of continuous response variations, or "response mapping." Unlike previous research in stimulus control, where a single stimulus comes to control a single response, 36 5-year-old children received errorless discrimination training at…

  10. Establishing a University Foundation.

    ERIC Educational Resources Information Center

    Lemish, Donald L.

    A handbook on how to establish a university foundation is presented. It presupposes that a foundation will be used as the umbrella organization for receiving all private gifts, restricted and unrestricted, for the benefit of a public college or university; and hence it chiefly addresses readers from public colleges and universities. Information is…

  11. Establishing Passing Scores.

    ERIC Educational Resources Information Center

    McLarty, Joyce R.

    The problem of establishing appropriate passing scores is one of evaluation rather than estimation and not amenable to exact solution. It must therefore be approached by (1) identifying criteria for judging the acceptability of the passing score, (2) collecting the data appropriate to assessing each relevant criterion, and (3) judging how well the…

  12. Establishing the Intermediate Unit.

    ERIC Educational Resources Information Center

    Pennsylvania State Dept. of Education, Harrisburg.

    The State of Pennsylvania Act 102 establishes a system of 29 intermediate units, creates intermediate unit boards of directors, spells out their duties and functions, and provides a system of financing their operations. This handbook has been prepared by the Pennsylvania Department of Education to provide intermediate unit boards of directors,…

  13. DEHP-plasticised PVC: relevance to blood services.

    PubMed

    Sampson, J; de Korte, D

    2011-04-01

    Phthalates are the most widely used plasticisers in the world and have been in medical use since 1955. Di(2-ethylhexyl)phthalate (DEHP) is present in many industrial and domestic products, and is a common plasticiser used in blood bags and tubing sets. Concerns have been raised by environmental groups that DEHP exposure may result in gender birth defects and the feminisation of boys although there were no studies performed of intravenous exposure to DEHP on higher mammals or humans which report similar effects. This article reports on the toxicology of DEHP and considers concerns regarding its use in the context of transfusion medicine. The benefits of using DEHP are evaluated and the use of alternative plasticisers to DEHP is explored. The article reports on international and European regulatory recommendations for DEHP use in transfusion medicine and examines the impact of legislation on the medical devices and blood industries. The article also reviews labelling considerations for blood components and offers some guidance for blood establishments in respect of DEHP use.

  14. Blood money.

    PubMed

    Cohen, S B

    2000-11-01

    Foetal blood contains cells that can regenerate all the cellular elements of blood and the immune system (stem cells). This blood can be obtained from the placenta without any harm to mother or baby and is currently used as a successful alternative to bone marrow for paediatric transplantation. Recently, it has been suggested that this blood can be put in storage and used (if needed) for the child that the blood originally came from. This has prompted a commercial interest, leading to both financial and ethical concerns.

  15. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2013-01-01

    Estimated 2012 world production of natural and synthetic industrial diamond was about 4.45 billion carats. During 2012, natural industrial diamonds were produced in at least 20 countries, and synthetic industrial diamond was produced in at least 12 countries. About 99 percent of the combined natural and synthetic global output was produced in Belarus, China, Ireland, Japan, Russia, South Africa and the United States. During 2012, China was the world’s leading producer of synthetic industrial diamond followed by the United States and Russia. In 2012, the two U.S. synthetic producers, one in Pennsylvania and the other in Ohio, had an estimated output of 103 million carats, valued at about $70.6 million. This was an estimated 43.7 million carats of synthetic diamond bort, grit, and dust and powder with a value of $14.5 million combined with an estimated 59.7 million carats of synthetic diamond stone with a value of $56.1 million. Also in 2012, nine U.S. firms manufactured polycrystalline diamond (PCD) from synthetic diamond grit and powder. The United States government does not collect or maintain data for either domestic PCD producers or domestic chemical vapor deposition (CVD) diamond producers for quantity or value of annual production. Current trade and consumption quantity data are not available for PCD or for CVD diamond. For these reasons, PCD and CVD diamond are not included in the industrial diamond quantitative data reported here.

  16. Establishment of Intestinal Bacteriology

    PubMed Central

    MITSUOKA, Tomotari

    2014-01-01

    Research on intestinal bacteria began around the end of the 19th century. During the last 5 decades of the 20th century, research on the intestinal microbiota made rapid progress. At first, in my work, I first developed a method of comprehensive analysis of the intestinal microbiota, and then I established classification and identification methods for intestinal anaerobes. Using these methods I discovered a number of ecological rules governing the intestinal microbiota and the role of the intestinl microbiota in health and disease. Moreover, using germfree animals, it was proven that the intestinal microbiota has a role in carcinogenesis and aging in the host. Thus, a new interdisciplinary field, “intestinal bacteriology” was established. PMID:25032084

  17. Research Projects in Industrial Technology.

    SciTech Connect

    United States. Bonneville Power Administration. Industrial Technology Section.

    1990-06-01

    The purpose of this booklet is to briefly describe ongoing and completed projects being carried out by Bonneville Power Administration's (BPA) Industrial Technology Section. In the Pacific Northwest, the industrial sector is the largest of the four consuming sectors. It accounted for thirty-nine percent of the total firm demand in the region in 1987. It is not easy to asses the conservation potential in the industrial sector. Recognizing this, the Northwest Power Planning Council established an objective to gain information on the size, cost, and availability of the conservation resource in the industrial sector, as well as other sectors, in its 1986 Power Plan. Specifically, the Council recommended that BPA operate a research and development program in conjunction with industry to determine the potential costs and savings from efficiency improvements in industrial processes which apply to a wide array of industrial firms.'' The section, composed of multidisciplinary engineers, provides technical support to the Industrial Programs Branch by designing and carrying out research relating to energy conservation in the industrial sector. The projects contained in this booklet are arranged by sector --industrial, utility, and agricultural -- and, within each sector, chronologically from ongoing to completed, with those projects completed most recently falling first. For each project the following information is given: its objective approach, key findings, cost, and contact person. Completed projects also include the date of completion, a report title, and report number.

  18. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2007-01-01

    World production of natural and synthetic industrial diamond was about 648 million carats in 2006, with 79 percent of the production coming from Ireland, Japan, Russia, South Africa, and the U.S. U.S. consumption was was an estimated 602 million carats, imports were over 391 million carats, and exports were about 83 million carats. About 87 percent of the industrial diamonds market uses synthetic diamonds, which are expected to become less expensive as technology improves and competition from low-cost producers increases.

  19. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2006-01-01

    In 2005, US production of crude garnet concentrate for industrial use was 28.4 kt valued at $3.05 million. Refined garnet material sold or used was 30.4 kt valued at $10 million. For the year, the US was one of the world's leading consumers of industrial garnet. Domestic values for crude concentrates for different applications ranged from about $53 to $120/t. In the short term, excess production capacity, combined with suppliers that vary in quality, grain size and mineral type, will keep prices down.

  20. 7 CFR 63.100 - Establishment and membership.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... hereby established a National Sheep Industry Improvement Center Board. The Board is composed of seven...: (a) Voting members. (1) Four members shall be active producers of sheep or goats in the United...

  1. 7 CFR 63.100 - Establishment and membership.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... hereby established a National Sheep Industry Improvement Center Board. The Board is composed of seven...: (a) Voting members. (1) Four members shall be active producers of sheep or goats in the United...

  2. 7 CFR 63.100 - Establishment and membership.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... hereby established a National Sheep Industry Improvement Center Board. The Board is composed of seven...: (a) Voting members. (1) Four members shall be active producers of sheep or goats in the United...

  3. 7 CFR 63.100 - Establishment and membership.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... hereby established a National Sheep Industry Improvement Center Board. The Board is composed of seven...: (a) Voting members. (1) Four members shall be active producers of sheep or goats in the United...

  4. Industrial lead poisoning in China over the past 33 years.

    PubMed

    Wang, Y L

    1984-12-01

    This paper is a review of the 48 articles in scientific journals and special reports of investigations emanating from the author's department involving 2504 subjects. During the past 33 years, as a result of the establishment of health and antiepidemic stations throughout the country, the enactment of hygienic standards, and the setting up of the reporting system for industrial poisoning and occupational diseases, the air lead level has been reduced from 10 mg/m3 in the years soon after liberation (1949) to below 0.03 mg/m3 at present. Severe plumbism has disappeared. Some mild cases, however, could still be found among workers in lead smelters and electric battery plants. Great advances have been made in techniques for early diagnosis of lead poisoning. Blood lead, urine lead, aminolevulinic dehydrase, free erythrocyte protoporphyrin, and zinc protoporphyrin (ZnPP) have been used as criteria for lead exposure. For the purpose of preventive monitoring, ZnPP as a screening index is the first choice. Behavioral function and sensory and motor nerve conduction velocity measurements of median nerve might also be used for the investigation of lead exposure. The maximum allowable concentration of 0.03 mg/m3 for air lead level in the workshop, in agreement with the results of a nationwide lead industry investigation, has been proven safe. There is also the need to monitor the air lead level and blood lead level in the general population and children living adjacent to a lead industry.

  5. Industrial lead poisoning in China over the past 33 years

    SciTech Connect

    Wang, Y.L.

    1984-12-01

    This paper is a review of the 48 articles in scientific journals and special reports of investigations emanating from the author's department involving 2504 subjects. During the past 33 years, as a result of the establishment of health and antiepidemic stations throughout the country, the enactment of hygienic standards, and the setting up of the reporting system for industrial poisoning and occupational diseases, the air lead level has been reduced from 10 mg/m3 in the years soon after liberation (1949) to below 0.03 mg/m3 at present. Severe plumbism has disappeared. Some mild cases, however, could still be found among workers in lead smelters and electric battery plants. Great advances have been made in techniques for early diagnosis of lead poisoning. Blood lead, urine lead, aminolevulinic dehydrase, free erythrocyte protoporphyrin, and zinc protoporphyrin (ZnPP) have been used as criteria for lead exposure. For the purpose of preventive monitoring, ZnPP as a screening index is the first choice. Behavioral function and sensory and motor nerve conduction velocity measurements of median nerve might also be used for the investigation of lead exposure. The maximum allowable concentration of 0.03 mg/m3 for air lead level in the workshop, in agreement with the results of a nationwide lead industry investigation, has been proven safe. There is also the need to monitor the air lead level and blood lead level in the general population and children living adjacent to a lead industry.

  6. Engineering Aspects in Blood Pump Development

    NASA Technical Reports Server (NTRS)

    Golding, Leonard; Veres, Joseph P.

    1997-01-01

    NASA turbomachinery computer codes assisted in the design of the Cleveland Clinic Foundation's centrifugal bladed blood pump. The codes were originally developed for the aerospace industry, but are applicable to the blood pump because of a high degree of synergy with this application. Traditional turbomachinery design criteria were used in the design of the blood pump centrifugal impeller and volute casing. The fluid dynamic performance of the blood pump is meeting the engineering design goals of flow rate and pressure rise.

  7. Engineering Aspects in Blood Pump Development

    NASA Technical Reports Server (NTRS)

    Golding, Leonard; Veres, Joseph P.

    1997-01-01

    NASA turbomachinery computer codes assisted in the design of the Cleveland Clinic Foundation's centrifugal bladed blood pump. The codes were originally developed for the aerospace industry, but are applicable to the blood pump because of a high degree of synergy with this application. Traditional turbomachinery design criteria were used in the design of the blood pump centrifugal impeller and volute casing. The fluid dynamic performance of the blood pump is meeting the engineering design goals of flow rate and pressure rise.

  8. Industrial Orientation.

    ERIC Educational Resources Information Center

    Rasor, Leslie; Brooks, Valerie

    These eight modules for an industrial orientation class were developed by a project to design an interdisciplinary program of basic skills training for disadvantaged students in a Construction Technology Program (see Note). The Drafting module overviews drafting career opportunities, job markets, salaries, educational requirements, and basic…

  9. Industrial Microorganisms.

    ERIC Educational Resources Information Center

    Phaff, Herman J.

    1981-01-01

    Describes industrially important yeasts, molds, bacteria, and actinomycetes. Discussed in detail are microbial products, such as primary metabolites, secondary metabolites, enzymes, and capsular polysaccharides. Traces the historical background of human cell culture, mentioning recombinant DNA research and hybridization of normal mammalian cells…

  10. Fermentation Industry.

    ERIC Educational Resources Information Center

    Grady, C. P. L., Jr.; Grady, J. K.

    1978-01-01

    Presents a literature review of wastes from the fermentation industry, covering publications of 1976-77. This review focuses on: (1) alcoholic beverage production; (2) pharmaceuticals and biochemicals production; and (3) biomass production. A list of 62 references is also presented. (HM)

  11. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2012-01-01

    Garnet has been used as a gemstone since the Bronze Age. However, garnet's angular fractures, relatively high hardness and specific gravity, chemical inertness, and nontoxicity make it ideal for many industrial applications. It is also free of crystalline silica and can be recycled.

  12. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2013-01-01

    Garnet has been used as a gemstone since the Bronze Age. However, garnet’s angular fractures, relatively high hardness and specific gravity, chemical inertness and nontoxicity make it ideal for many industrial applications. It is also free of crystalline silica and can be recycled.

  13. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2011-01-01

    Garnet has been used as a gemstone since the Bronze Age. However, garnet's angular fractures, relatively high hardness and specific gravity, chemical inertness and nontoxicity make it ideal for many industrial applications. It is also free of crystalline silica and can be recycled.

  14. Fermentation Industry.

    ERIC Educational Resources Information Center

    Grady, C. P. L., Jr.; Grady, J. K.

    1978-01-01

    Presents a literature review of wastes from the fermentation industry, covering publications of 1976-77. This review focuses on: (1) alcoholic beverage production; (2) pharmaceuticals and biochemicals production; and (3) biomass production. A list of 62 references is also presented. (HM)

  15. Fermentation industry

    SciTech Connect

    Chiesa, S.C.; Manning, J.F. Jr.

    1983-06-01

    A literature review of the fermenation industry's wastes is presented. In addition to studies on the characterization, treatment, and disposal of wastes in alcohol fuel production, studies concerning wastes from breweries, wineries, yeast manufacture, pharmaceutical production, and distilleries are reviewed. (JMT)

  16. Industrial Microorganisms.

    ERIC Educational Resources Information Center

    Phaff, Herman J.

    1981-01-01

    Describes industrially important yeasts, molds, bacteria, and actinomycetes. Discussed in detail are microbial products, such as primary metabolites, secondary metabolites, enzymes, and capsular polysaccharides. Traces the historical background of human cell culture, mentioning recombinant DNA research and hybridization of normal mammalian cells…

  17. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2010-01-01

    In 2009, U.S. production of crude garnet concentrate for industrial use was estimated to be 56.5 kt (62,300 st), valued at about $8.85 million. This was a 10-percent decrease in quantity compared with 2008 production. Refined garnet material sold or used was 28 kt (31,000 st) valued at $7.96 million.

  18. 76 FR 48167 - Agency Information Collection Activities; Proposed Collection; Comment Request; Blood...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... banks, certain transfusion services, other blood product manufacturers, and independent laboratories... Collection; Comment Request; Blood Establishment Registration and Product Listing, Form FDA 2830 AGENCY: Food... blood establishment registration and product listing requirements in the Agency's regulations and...

  19. Established antiepileptic drugs.

    PubMed

    Brodie, M J; Dichter, M A

    1997-06-01

    Despite the recent entry into the market-place of a range of new pharmacological treatments for epilepsy, most patients still receive the standard antiepileptic drugs. This review considers the clinical place and practical use of these agents. Detailed consideration is given to carbamazepine, phenytoin, sodium valproate, phenobarbital and ethosuximide, with lesser emphasis on primidone, clobazam and clonazepam. Individualization of therapy, polypharmacy, refractory epilepsy, therapeutic drug monitoring, pregnancy, withdrawing treatment, epilepsy prophylaxis and referral to an epilepsy centre are also discussed. The paper concludes with a statement of 12 basic rules in prescribing established antiepileptic drugs.

  20. Establishing a flatness standard.

    PubMed

    Elssner, K E; Vogel, A; Grzanna, J; Schulz, G

    1994-05-01

    A further-developed three-plate rotation method [Appl. Opt. 31, 3767 (1992)] for the absolute testing of flats is used as a measuring method for establishing flatness standards. A special phase-stepping Fizeau interferometer was built that permits flats of diameters up to 200 mm to be tested. First results show a mean error between 0.002 and 0.003 λ in the determination of the absolute flatness deviations (λ = 632.8 nm). These deviations are obtained at 500-600 points on each plate. A number of experimental conditions connected with the thermal and mechanical stability of the plates must be fulfilled.

  1. Blood Analyzer

    NASA Technical Reports Server (NTRS)

    1992-01-01

    In the 1970's, NASA provided funding for development of an automatic blood analyzer for Skylab at the Oak Ridge National Laboratory (ORNL). ORNL devised "dynamic loading," which employed a spinning rotor to load, transfer, and analyze blood samples by centrifugal processing. A refined, commercial version of the system was produced by ABAXIS and is marketed as portable ABAXIS MiniLab MCA. Used in a doctor's office, the equipment can perform 80 to 100 chemical blood tests on a single drop of blood and report results in five minutes. Further development is anticipated.

  2. 13 CFR 121.102 - How does SBA establish size standards?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requests to change existing size standards or establish new ones for emerging industries to the Division... the structure of an industry, including degree of competition, average firm size, start-up costs and... from other industries, growth trends, historical activity within an industry, unique factors...

  3. 13 CFR 121.102 - How does SBA establish size standards?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... requests to change existing size standards or establish new ones for emerging industries to the Division... the structure of an industry, including degree of competition, average firm size, start-up costs and... from other industries, growth trends, historical activity within an industry, unique factors...

  4. 75 FR 54343 - Center for Biologics Evaluation and Research eSubmitter Pilot Evaluation Program for Blood...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ... Pilot Evaluation Program for Blood Establishments That Collect Whole Blood and Blood Components AGENCY... automated biologics license application (BLA) and BLA supplement (BLS) submission system for blood and blood components. Participation in the pilot program is open to blood establishments that collect Whole Blood...

  5. Application of Six Sigma/CAP methodology: controlling blood-product utilization and costs.

    PubMed

    Neri, Robert A; Mason, Cindy E; Demko, Lisa A

    2008-01-01

    Blood-product components are a limited commodity whose cost is rising. Many patients benefit from their use, but patients who receive transfusions face an unnecessary increased risk for developing infections; fatal, febrile, or allergic reactions; and circulatory overload. To improve patient care, safety, and resource stewardship, transfusion practices must be evaluated for appropriateness (Wilson et al. 2002). A multihospital health system undertook a rigorous study of blood-product utilization patterns and management processes to address cost-control problems in the organization. The system leveraged two process improvement tools widely implemented outside of the healthcare industry: (1) Six Sigma methodology to identify blood-utilization drivers and to standardize transfusion practice, and (2) change acceleration process model to drive effective change. The initiative resulted in a decreased rate of inappropriate transfusions of packed red blood cell from 16 percent to less than 5 percent, improved clinician use of a blood-component order form, establishment of internal benchmarks, enhanced laboratory-to-clinician communication, and better blood-product expense control. The project further demonstrated how out-of-industry tools and methodologies can be adopted, adapted, and systematically applied to generate positive change (Black and Revere 2006).

  6. Blood flow

    MedlinePlus

    ... the same time, the veins carry oxygen-poor blood (shown in blue) from the tissues back toward the heart. From there, it passes to the lungs to receive more oxygen. This cycle repeats itself when oxygen-rich blood returns to the heart from the lungs, which ...

  7. Blood Types

    MedlinePlus

    ... low blood pressure. It can even lead vital body systems — like breathing or kidneys — to fail. Here's an ... in Type B or AB blood) enter your body, your Type A immune system gets fired up against them. That means you ...

  8. Blood Types

    MedlinePlus

    ... cells (and A antibody in the plasma) Group AB – has both A and B antigens on red ... 9% 25% B - 2% 1% 1% 0.4% AB + 3% 4% 2% 7% AB - 1% 0.3% 0.2% 0.1% Some ... Whether your blood group is type A, B, AB or O is based on the blood types ...

  9. 13 CFR 121.102 - How does SBA establish size standards?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... in the industry. SBA will take into consideration market share of a concern and other appropriate... requests to change existing size standards or establish new ones for emerging industries to the Division...

  10. Establishing a Presence

    NASA Technical Reports Server (NTRS)

    McCandless, Jeffrey

    2005-01-01

    The basis for this successful collaboration was face-to-face communication. Though it was sometimes stressful being on the road so much, I really learned the importance of being present to work together and ask questions in person. Another measure of success was that in the midst of this project and traveling, my wife and I managed to start a family. My oldest boy got a real kick out of visiting Space Center Houston when he was two to learn all about the "face futtle" which goes way up in the sky. When practical, collocation and face-to-face communication on a project eliminate misunderstandings, establish relationships, make information more easily accessible, and promote a team atmosphere. Compromise is key to balancing both family and career goals. Knowing when to prioritize each is important to success in both aspects.

  11. On establishing reference values.

    PubMed Central

    Lumsden, J H; Mullen, K

    1978-01-01

    In order to establish a range of reference values for any characteristic one can use Gaussian or nonparametric techniques, whichever are most appropriate. One has the choice of calculating tolerance intervals or percentile intervals. A tolerance interval is said to contain, say 95% of the population with probability, say 0.90. A percentile interval simply simply calculates the values between which 95% of the observations fall. If the data can be said to have a Gaussian distribution, the same precision can be obtained with smaller sample sizes than using the nonparametric techniques. In some cases, data which are not Gaussian can be transformed into a Gaussian form and hence make use of the more efficient Gaussian techniques. In both cases, the data should be checked for outliers or rogue observations and these should be eliminated if the testing procedure fails to imply that they are an integral part of the data. PMID:688072

  12. Establishing Substantial Equivalence: Transcriptomics

    NASA Astrophysics Data System (ADS)

    Baudo, María Marcela; Powers, Stephen J.; Mitchell, Rowan A. C.; Shewry, Peter R.

    Regulatory authorities in Western Europe require transgenic crops to be substantially equivalent to conventionally bred forms if they are to be approved for commercial production. One way to establish substantial equivalence is to compare the transcript profiles of developing grain and other tissues of transgenic and conventionally bred lines, in order to identify any unintended effects of the transformation process. We present detailed protocols for transcriptomic comparisons of developing wheat grain and leaf material, and illustrate their use by reference to our own studies of lines transformed to express additional gluten protein genes controlled by their own endosperm-specific promoters. The results show that the transgenes present in these lines (which included those encoding marker genes) did not have any significant unpredicted effects on the expression of endogenous genes and that the transgenic plants were therefore substantially equivalent to the corresponding parental lines.

  13. Noninvasive blood pressure measurement scheme based on optical fiber sensor

    NASA Astrophysics Data System (ADS)

    Liu, Xianxuan; Yuan, Xueguang; Zhang, Yangan

    2016-10-01

    Optical fiber sensing has many advantages, such as volume small, light quality, low loss, strong in anti-jamming. Since the invention of the optical fiber sensing technology in 1977, optical fiber sensing technology has been applied in the military, national defense, aerospace, industrial, medical and other fields in recent years, and made a great contribution to parameter measurement in the environment under the limited condition .With the rapid development of computer, network system, the intelligent optical fiber sensing technology, the sensor technology, the combination of computer and communication technology , the detection, diagnosis and analysis can be automatically and efficiently completed. In this work, we proposed a noninvasive blood pressure detection and analysis scheme which uses optical fiber sensor. Optical fiber sensing system mainly includes the light source, optical fiber, optical detector, optical modulator, the signal processing module and so on. wavelength optical signals were led into the optical fiber sensor and the signals reflected by the human body surface were detected. By comparing actual testing data with the data got by traditional way to measure the blood pressure we can establish models for predicting the blood pressure and achieve noninvasive blood pressure measurement by using spectrum analysis technology. Blood pressure measurement method based on optical fiber sensing system is faster and more convenient than traditional way, and it can get accurate analysis results in a shorter period of time than before, so it can efficiently reduce the time cost and manpower cost.

  14. Shipbuilding Industry

    DTIC Science & Technology

    2006-01-01

    vessels, the industry cannot compete internationally due to higher costs and prices . On the commercial side, based on information provided during...challenges. The defense sector, though producing the most advanced ships in the world, does so at exorbitant prices , limiting the number that the U.S...Navy can afford. Based on visits to twenty-four U.S. and Australian shipyards, the U.S. government should provide targeted support to the commercial

  15. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2007-01-01

    World production of industrial garnet was about 326 kt in 2006, with the U.S. producing about 11 percent of this total. U.S. consumption, imports, and exports were estimated at 74.3 kt, 52.3 kt, and 13.2 kt, respectively. The most important exporters are Australia, China, and India. Although demand is expected to rise over the next 5 years, prices are expected to remain low in the short term.

  16. Industrial radiointroscopy

    NASA Astrophysics Data System (ADS)

    Kliuev, V. V.; Leonov, B. I.; Gusev, E. A.

    The operating principles and design of various types of radiointroscopes used in industry for fault inspection are described, together with the sources of penetrating radiation, radiooptic image converters, and image amplifiers. The theory of image formation by a radiointroscope and mathematical models of the image formation are discussed. Consideration is given to the design of radioscope television systems, and their optical characteristics, resolving power, signal/noise characteristics, contrast sensitivity, and the transmission band of the communication channel.

  17. Industrial systems biology.

    PubMed

    Otero, José Manuel; Nielsen, Jens

    2010-02-15

    The chemical industry is currently undergoing a dramatic change driven by demand for developing more sustainable processes for the production of fuels, chemicals, and materials. In biotechnological processes different microorganisms can be exploited, and the large diversity of metabolic reactions represents a rich repository for the design of chemical conversion processes that lead to efficient production of desirable products. However, often microorganisms that produce a desirable product, either naturally or because they have been engineered through insertion of heterologous pathways, have low yields and productivities, and in order to establish an economically viable process it is necessary to improve the performance of the microorganism. Here metabolic engineering is the enabling technology. Through metabolic engineering the metabolic landscape of the microorganism is engineered such that there is an efficient conversion of the raw material, typically glucose, to the product of interest. This process may involve both insertion of new enzymes activities, deletion of existing enzyme activities, but often also deregulation of existing regulatory structures operating in the cell. In order to rapidly identify the optimal metabolic engineering strategy the industry is to an increasing extent looking into the use of tools from systems biology. This involves both x-ome technologies such as transcriptome, proteome, metabolome, and fluxome analysis, and advanced mathematical modeling tools such as genome-scale metabolic modeling. Here we look into the history of these different techniques and review how they find application in industrial biotechnology, which will lead to what we here define as industrial systems biology.

  18. How to establish and sustain a joint venture in China.

    PubMed

    Lee, Paul

    2008-01-01

    Joint ventures with Chinese companies provide one of the most effective ways for international companies to establish a foothold in the booming Chinese economy. The benefits, opportunities and challenges of establishing a joint venture are explored here. Current partnering trends and successful Sino-foreign joint ventures in the fast-growing medical device industry in China are also highlighted.

  19. 7 CFR 1217.40 - Establishment and membership.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Establishment and membership. 1217.40 Section 1217.40... Education, and Industry Information Order Definitions § 1217.40 Establishment and membership. (a... membership to reflect changes in the geographical distribution of the volume of softwood lumber...

  20. 7 CFR 1217.40 - Establishment and membership.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Establishment and membership. 1217.40 Section 1217.40... Education, and Industry Information Order Definitions § 1217.40 Establishment and membership. (a... membership to reflect changes in the geographical distribution of the volume of softwood lumber...

  1. 7 CFR 1217.40 - Establishment and membership.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Establishment and membership. 1217.40 Section 1217.40... Education, and Industry Information Order Definitions § 1217.40 Establishment and membership. (a... warranted, recommend to the Secretary the reapportionment of the Board membership to reflect changes in...

  2. 28 CFR 301.314 - Establishing the amount of award.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Establishing the amount of award. 301.314 Section 301.314 Judicial Administration FEDERAL PRISON INDUSTRIES, INC., DEPARTMENT OF JUSTICE INMATE ACCIDENT COMPENSATION Compensation for Work-Related Physical Impairment or Death § 301.314 Establishing the amount of award. (a) If a claim for...

  3. 7 CFR 1951.133 - Establishment of Federal Debt.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 14 2013-01-01 2013-01-01 false Establishment of Federal Debt. 1951.133 Section 1951... Agency Borrowers § 1951.133 Establishment of Federal Debt. Any amounts paid by RBS on account of liabilities of a business and industry (B&I) program guaranteed loan borrower will constitute a Federal debt...

  4. 7 CFR 1951.133 - Establishment of Federal Debt.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Establishment of Federal Debt. 1951.133 Section 1951... Agency Borrowers § 1951.133 Establishment of Federal Debt. Any amounts paid by RBS on account of liabilities of a business and industry (B&I) program guaranteed loan borrower will constitute a Federal debt...

  5. 7 CFR 1951.133 - Establishment of Federal Debt.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 14 2012-01-01 2012-01-01 false Establishment of Federal Debt. 1951.133 Section 1951... Agency Borrowers § 1951.133 Establishment of Federal Debt. Any amounts paid by RBS on account of liabilities of a business and industry (B&I) program guaranteed loan borrower will constitute a Federal debt...

  6. 7 CFR 1951.133 - Establishment of Federal Debt.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 14 2014-01-01 2014-01-01 false Establishment of Federal Debt. 1951.133 Section 1951... Agency Borrowers § 1951.133 Establishment of Federal Debt. Any amounts paid by RBS on account of liabilities of a business and industry (B&I) program guaranteed loan borrower will constitute a Federal debt...

  7. 7 CFR 1951.133 - Establishment of Federal Debt.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Establishment of Federal Debt. 1951.133 Section 1951... Agency Borrowers § 1951.133 Establishment of Federal Debt. Any amounts paid by RBS on account of liabilities of a business and industry (B&I) program guaranteed loan borrower will constitute a Federal debt...

  8. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  9. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  10. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  11. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  12. 21 CFR 864.9050 - Blood bank supplies.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... such as blood bank pipettes, blood grouping slides, blood typing tubes, blood typing racks, and cold... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Blood bank supplies. 864.9050 Section 864.9050...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture...

  13. 21 CFR 864.9050 - Blood bank supplies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... such as blood bank pipettes, blood grouping slides, blood typing tubes, blood typing racks, and cold... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Blood bank supplies. 864.9050 Section 864.9050...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture...

  14. 21 CFR 864.9050 - Blood bank supplies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... such as blood bank pipettes, blood grouping slides, blood typing tubes, blood typing racks, and cold... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Blood bank supplies. 864.9050 Section 864.9050...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture...

  15. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  16. Establishing lunar resource viability

    NASA Astrophysics Data System (ADS)

    Carpenter, J.; Fisackerly, R.; Houdou, B.

    2016-11-01

    Recent research has highlighted the potential of lunar resources as an important element of space exploration but their viability has not been demonstrated. Establishing whether or not they can be considered in future plans is a multidisciplinary effort, requiring scientific expertise and delivering scientific results. To this end various space agencies and private entities are looking to lunar resources, extracted and processed in situ, as a potentially game changing element in future space architectures, with the potential to increase scale and reduce cost. However, before any decisions can be made on the inclusion of resources in exploration roadmaps or future scenarios some big questions need to be answered about the viability of different resource deposits and the processes for extraction and utilisation. The missions and measurements that will be required to answer these questions, and which are being prepared by agencies and others, can only be performed through the engagement and support of the science community. In answering questions about resources, data and knowledge will be generated that is of fundamental scientific importance. In supporting resource prospecting missions the science community will de facto generate new scientific knowledge. Science enables exploration and exploration enables science.

  17. 21 CFR 607.26 - Amendments to establishment registration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Amendments to establishment registration. 607.26... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND... registration. Changes in individual ownership, corporate or partnership structure, location, or...

  18. Manufacturing Industry, Industry Study, Spring 2009

    DTIC Science & Technology

    2009-01-01

    Spring 2009 Industry Study Final Report Manufacturing Industry ...The Industrial College of the Armed Forces National Defense University Fort McNair, Washington, D.C. 20319-5062 Report Documentation Page Form...COVERED 00-00-2009 to 00-00-2009 4. TITLE AND SUBTITLE Spring 2009. Industry Study. Manufacturing Industry 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

  19. Do blood-borne calcifying nanoparticles self-propagate?

    PubMed Central

    Mathew, Grace; McKay, David S; Çiftçioglu, Neva

    2008-01-01

    The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus, one can easily conjecture the impact of a nanoparticle if it could also self-replicate. This in vitro study reveals the self-propagating ability of unique calcifying nanoparticles (CNP) that can be as small as 50 nm in size and found in blood, blood products, and calcified soft tissues. Although specific detection techniques, morphological characteristics and biomineralizing properties of CNP are well established, their genomic information and self-propagating capability have always been challenged. The objective of this study is to document the propagation of CNP under physiological conditions, using inverted light microscopy (LM) and the Biostation IM time-lapse imaging system. Their detailed morphological structure was examined using scanning (SEM) and transmission (TEM) electron microscopy. This present study, in conjunction with previous findings of metabolic activity, antibiotic sensitivity, antibody specificity, morphological aspects and infectivity, validates CNP as self-replicators. Therefore these sterile-filterable, blood-borne nanoparticles should be of concern to the nanomedicine industry. PMID:18686786

  20. Do blood-borne calcifying nanoparticles self-propagate?

    PubMed

    Mathew, Grace; Mckay, David S; Ciftçioglu, Neva

    2008-01-01

    The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus, one can easily conjecture the impact ofa nanoparticle if it could also self-replicate. This in vitro study reveals the self-propagating ability of unique calcifying nanoparticles (CNP) that can be as small as 50 nm in size and found in blood, blood products, and calcified soft tissues. Although specific detection techniques, morphological characteristics and biomineralizing properties of CNP are well established, their genomic information and self-propagating capability have always been challenged. The objective of this study is to document the propagation of CNP under physiological conditions, using inverted light microscopy (LM) and the Biostation IM time-lapse imaging system. Their detailed morphological structure was examined using scanning (SEM) and transmission (TEM) electron microscopy. This present study, in conjunction with previous findings of metabolic activity, antibiotic sensitivity, antibody specificity, morphological aspects and infectivity, validates CNP as self-replicators. Therefore these sterile-filterable, blood-borne nanoparticles should be of concern to the nanomedicine industry.

  1. Storing Blood Cells

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The National Cancer Institute worked with Goddard Space Flight Center to propose a solution to the blood-cell freezing problem. White blood cells and bone marrow are stored for future use by leukemia patients as a result of Goddard and Jet Propulsion Laboratory expertise in electronics and cryogenics. White blood cell and bone marrow bank established using freezing unit. Freezing unit monitors temperature of cells themselves. Thermocouple placed against polyethylene container relays temperature signals to an electronic system which controls small heaters located outside container. Heaters allow liquid nitrogen to circulate at constant temperature and maintain consistent freezing rate. Ability to freeze, store, and thaw white cells and bone marrow without damage is important in leukemia treatment.

  2. US Army blood program: 2025 and beyond.

    PubMed

    Gonzales, Richard; Taylor, Audra L; Atkinson, Andrew J; Malloy, Wilbur W; Macdonald, Victor W; Cap, Andrew P

    2016-03-01

    In preparing to support the Army in 2025 and beyond, the Army Blood Program remains actively engaged with the research and advanced development of blood products and medical technology to improve blood safety and efficacy in conjunction with the US Army Medical Research and Materiel Command. National and International Blood Bank authorities have noted that the US Army research and development efforts in providing new blood products and improving blood safety operate on the cutting edge of technology and are transformational for the global blood industry. Over the past 14 years, the Army has transformed how blood support is provided and improved the survival rate of casualties. Almost every product or process developed by or for the military has found an application in treating civilian patients. Conflicts have many unwanted consequences; however, in times of conflict, one positive aspect is the identification of novel solutions to improve the safety and efficacy of the blood supply.

  3. Industrial concerns

    NASA Astrophysics Data System (ADS)

    2008-04-01

    Physics in industry is worth reporting, but deciding what counts can be a challenge "If a man can make a better mousetrap than his neighbour...the world will make a beaten path to his door." That quotation, which was apparently inspired by a comment that the American essayist Ralph Waldo Emerson made during a lecture in 1871, has long been used to illustrate the power of invention and innovation. While the lowly mousetrap may hardly seem the pinnacle of technology in today's world of iPhones and Blu-ray DVDs, an effective tool to kill mice was certainly a desirable object in Emerson's day (p52).

  4. Biomass energy industry sourcebook

    SciTech Connect

    Troxell, D.L.

    1989-03-01

    The report is a directory of persons/establishments involved with different aspects of the biomass energy industry. These include consulting, engineering design, construction, manufacturing, retail, information, education, and research. Listings include name, address, phone, and a brief description of each firm/organization. Entries are categorized as follows: Consultants and Engineers, Alcohol Production Equipment/Systems, Methane Production Equipment/Systems, Combustion Equipment/Systems, Fuel Processing, Harvesting Equipment/Systems, Silviculture, Transportation, Storage, and Handling, Information Sources, and Databases. The report has been expanded and revised from a previous edition.

  5. Blood Donation

    MedlinePlus

    ... is then separated into its components — red cells, plasma, platelets. Apheresis During apheresis, you are hooked up ... collect and separate blood components, including red cells, plasma, platelets, and return unused components back to the ...

  6. Blood smear

    MedlinePlus

    ... an enzyme called lecithin cholesterol acyl transferase Abnormal hemoglobin , the protein in red blood cells that carries ... Disorder in which there is excessive breakdown of hemoglobin ( thalassemia ) The presence of cells called burr cells ...

  7. Amylase - blood

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/003464.htm Amylase - blood To use the sharing features on this page, please enable JavaScript. Amylase is an enzyme that helps digest carbohydrates. It ...

  8. What's Blood?

    MedlinePlus

    ... catch the blood when you scrape your knee! Plasma Plasma (say: PLAZ-muh) is a yellowish liquid that ... bones and muscles to grow. Many proteins in plasma are really important to your body, like the ...

  9. Blood Smear

    MedlinePlus

    ... their function, and their lifespan. Examples include anemia , myeloproliferative neoplasms , bone marrow disorders , and leukemia . Usually, only normal, ... the number of eosinophils Leukemia or myelodysplastic or myeloproliferative neoplasm — immature white blood cells such as blasts may ...

  10. Current good manufacturing practices for blood and blood components: notification of consignees receiving blood and blood components at increased risk for transmitting HIV infection--FDA. Final rule.

    PubMed

    1996-09-09

    The Food and Drug Administration (FDA) is amending the biologics regulations to require that blood establishments (including plasma establishments) prepare and follow written procedures for appropriate action when it is determined that Whole Blood, blood components (including recovered plasma), Source Plasma and Source Leukocytes at increased risk for transmitting human immunodeficiency virus (HIV) infection have been collected. This final rule requires that when a donor who previously donated blood is tested on a later donation in accordance with the regulations and tests repeatedly reactive for antibody to HIV, the blood establishment shall perform more specific testing using a licensed test, if available, and notify consignees who received Whole Blood, blood components, Source Plasma or Source Leukocytes from prior collections so that appropriate action is taken. Blood establishments and consignees are required to quarantine previously collected Whole Blood, blood components, Source Plasma and Source Leukocytes from such donors, and if appropriate, notify transfusion recipients. The Health Care Financing Administration (HCFA) is also issuing a final rule, published elsewhere in this Federal Register, which requires all transfusion services subject to HCFA's conditions of Medicare participation for hospitals to notify transfusion recipients who have received Whole Blood or blood components from a donor whose subsequent donation test results are positive for antibody to HIV (hereinafter referred to as HCFA's final rule). FDA is requiring transfusion services that do not participate in Medicare and are, therefore, not subject to HCFA's final rule, to take steps to notify transfusion recipients. FDA is taking this action to help ensure the continued safety of the blood supply, and to help ensure that information is provided to consignees of Whole Blood, blood components, Source Plasma and Source Leukocytes and to recipients of Whole Blood and blood components from a

  11. Moving blood.

    PubMed

    Pelis, K

    1997-01-01

    Our internationally acclaimed journalist Sanguinia has returned safely from her historic assignment. Travelling from Homeric Greece to British Romanticism, she was witness to blood drinking, letting, bathing, and transfusion. In this report, she explores connections between the symbolic and the sadistic; the mythic and the medical--all in an effort to appreciate the layered meanings our culture has given to the movement of blood between our bodies.

  12. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore....

  13. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore....

  14. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore....

  15. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore....

  16. Information for Industrial Development,

    DTIC Science & Technology

    Information processing, *Technology transfer, * Industries , Information transfer, Industrial engineering , Planning, Research management, Investments...Operation, Industrial production, Data bases, Information systems, User needs, Symposia

  17. Biology of Blood

    MedlinePlus

    ... here for the Professional Version Home Blood Disorders Biology of Blood Overview of Blood Resources In This ... Version. DOCTORS: Click here for the Professional Version Biology of Blood Overview of Blood Components of Blood ...

  18. Blood Transfusion and Donation

    MedlinePlus

    ... receiving the blood transfusion. To keep blood safe, blood banks carefully screen donated blood. The risk of catching ... one or more times before the surgery. A blood bank will store your blood for your use. NIH: ...

  19. Blood Facts and Statistics

    MedlinePlus

    ... Home > Learn About Blood > Blood Facts and Statistics Blood Facts and Statistics Facts about blood needs Facts ... about American Red Cross Blood Services Facts about blood needs Every two seconds someone in the U.S. ...

  20. 77 FR 25721 - Small Entity Compliance Guide: Bottled Water: Quality Standard: Establishing an Allowable Level...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... HUMAN SERVICES Food and Drug Administration Small Entity Compliance Guide: Bottled Water: Quality... availability of a guidance for industry entitled ``Bottled Water: Quality Standard: Establishing an Allowable... its bottled water standard of quality regulations by establishing an allowable level for...

  1. Blood and War

    PubMed Central

    Hedley-Whyte, John; Milamed, Debra R

    2010-01-01

    SUMMARY In 1894 Ulsterman and pathologist Almroth Wright described the citation of blood. Twenty-one years later it was introduced into wartime and clinical practice. Harvard Medical School had a large part in providing Colonel Andrew Fullerton, later Professor of Surgery, Queen's Belfast, with the intellectual and practical help for the Allies to deploy blood on the post-Somme Western Front and in Salonika. The key investigators and clinicians were Americans and Canadians who with Fullerton and Wright instructed the Allies. The key enablers were two Harvard-trained surgeons surnamed Robertson—Oswald H. (“Robby”) and L. Bruce (no relation). Physician Roger I. Lee of Harvard, surgeon George W Crile of Cleveland, Peyton Rous of the Rockefeller Institute and Richard Lewisohn of Mount Sinai Hospital, both located in the Upper East Side of New York City, played key roles. By Armistice in 1918, indirect citrated nutrient-enhanced blood transfusion was widely used by the Allies. Geoffrey Keynes was taught the techniques of blood transfusion by Dr. Benjamin Harrison Alton of Harvard at a Casualty Clearing Station near Albert at the time of the Battle of Passchendaele. Professor “Robby” Robertson, DSO, Sir Geoffrey Keynes and Sir Thomas Houston established blood banking. PMID:22375087

  2. [Cord blood banking].

    PubMed

    Cepulić, Branka Golubić; Bojanić, Ines; Mazić, Sanja

    2009-06-01

    Transplantation of cord blood stem cells is a new and rapidly developing area. It has been used as a treatment for many diseases such as hematologic malignancies, primary immune deficiencies and metabolic diseases. Recently, stem cells have been used in regenerative medicine, particularly in neurodegenerative and cardiovascular diseases. For these reasons interest has been growing in banking cord blood. To be able to find an acceptable donor for any recipient in need, it is necessary to have on stock a great diversity of cells with different genetic types from different populations. Networks of banks and registries have been created around the world in order to share and exchange transplants. Public banks organize collection for altruistic donor of cord blood for unrelated hematopoietic stem cell transplantation and for directed donation in families at risk. But there are increasing numbers of families that are requesting storage of cord blood for possible future therapeutic use in the family. Establishment of cord blood banks has raised a number of important scientific, legal, ethical and political issues, which are discussed in this paper.

  3. Reactions of latent prints exposed to blood.

    PubMed

    Praska, Nicole; Langenburg, Glenn

    2013-01-10

    We explored whether an undeveloped latent print (fingermark) exposed to blood and later developed by enhancement with blood reagents such as amido black (AB) or leucocrystal violet (LCV) could appear as a genuine blood mark. We examined three different experimental conditions. In Experiment I, fingermark residue only was tested, as a control to confirm that fingermark residue alone does not react with the blood reagents AB and LCV. Experiment II investigated whether latent fingermarks exposed to blood dilutions could be treated with AB or LCV and subsequently appear as a genuine blood mark enhanced with AB or LCV. Experiment III tested whether latent fingermarks exposed to whole blood could be processed with AB or LCV and subsequently appear as a genuine blood mark enhanced with AB or LCV. The present study found that indeed, fingermark residue alone does not react with the blood reagents AB and LCV. In Experiment II, an interaction occurred between the fingermark residue and the diluted blood that caused the ridges to appear a red color. In the present study, this interaction is called a faux blood mark. While the faux blood mark phenomenon occurred most often following exposure to diluted blood, it did not occur consistently, and a predictable pattern could not be established. However, the reaction occurred more frequently following extended fingermark residue drying times. Faux blood marks are distinguishable from genuine blood marks prior to enhancement with blood reagents. Following treatment with blood reagents, it became increasingly difficult to determine whether the enhanced mark was a genuine blood print or a latent fingermark exposed to diluted blood. Latent fingermarks exposed to whole blood often resulted in a void prior to enhancement, but following treatment with blood reagents, were difficult to distinguish from a genuine blood mark enhanced with blood reagents.

  4. Industrial furnace

    SciTech Connect

    Shostak, V.M.; Tolochko, A.I.; Volkov, V.P.; Maradudin, G.I.; Schekin, N.G.; Popov, M.I.; Shepelev, D.N.; Matveev, A.I.; Butnyakov, A.I.; Rzhavichev, A.P.

    1986-09-02

    An industrial furnace is described which consists of: a bath made of a refractory material for filling with a melt; a direct current source; main current-carrying elements having free ends extending to an operating area of the refractory material of the bath below and above the melt, and the main current-carrying elements extending to the operating area below the melt being connected with opposite terminals of the current source from the main current-carrying elements extending to the operating area above the melt; and additional current-carrying elements having free ends sunk in the refractory material of the bath below and above the melt and the additional current-carrying elements being connected with the terminals of the power source of opposite polarity with respect to the connection of the main current-carrying elements of a corresponding part of the operating area.

  5. Industry Support

    NASA Technical Reports Server (NTRS)

    2003-01-01

    NASA Glenn Research Center (GRC) is responsible for the Advanced Communications for Air Traffic Management (AC/ATM) Project, a sub-element task of the Advanced Air Transportation Technologies (AATT) Project of the NASA Aviation System Capacity Program (ASC). The AC/ATM Project is developing new communications technologies and tools that will improve throughput in the U.S. Air Traffic Control System. The goal of the AC/ATM Project is to enable a communications infrastructure providing the capacity, efficiency, and flexibility necessary to realize benefits of the future mature Free-Flight environment. The capabilities and scope of communications technologies needed to accomplish this goal depend on characteristics of the future Free-Flight environment. There are many operational concepts being proposed for a future ATM system to enable user flexibility and efficiency. GRC s focus is on developing new technologies and techniques to support the digital communication of information involving airborne and ground-based users. However, the technologies and techniques must be integrated with the systems and services that industry and the Federal Aviation Administration (FAA) are developing. Thus, GRC needs to monitor and provide input to the various industry and FAA organizations and committees that are specifying new systems and services. Adoption of technologies by the FAA is partially dependent on acceptance of the technology by the aviation community. The commercial aviation community in particular would like to adopt technologies that can be used throughout the world. As a result, the adoption of common or at least compatible technologies by European countries is a key factor in getting commitments to those technologies by the US aviation community. GRC desires to keep informed of European activities that relate to aviation communication technologies, particularly those that are being supported by Eurocontrol.

  6. Fluorescence switch on-off-on receptor constructed of quinoline allied calix[4]arene for selective recognition of Cu2+ from blood serum and F- from industrial waste water.

    PubMed

    Sutariya, Pinkesh G; Pandya, Alok; Lodha, Anand; Menon, Shobhana K

    2013-05-07

    A novel PET with ICT based substituted calix[4]arene fluroionophore was synthesized and used for detection of Cu(2+) and F(-) by emission spectra. The detection limit of the synthesized receptor was found to be 4.16 nM for Cu(2+) and 2.15 nM for F(-). Moreover, this probe has been applied for recognition of Cu(2+) in blood serum and F(-) from waste water.

  7. Comment: Industrial Training and Sandwich Courses

    ERIC Educational Resources Information Center

    Brookes, D.

    1973-01-01

    Discusses the purposes and benefits of sandwich courses, which are now an established feature of the British system of higher education. These courses provide students with a period of industrial experience sandwiched between academic periods in college. (JR)

  8. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  9. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  10. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  11. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  12. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  13. Blood Collection

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The method that is used for the collection, storage and real-time analysis of blood and other bodily fluids has been licensed to DBCD, Inc. by NASA. The result of this patent licensing agreement has been the development of a commercial product that can provide serum or plasma from whole blood volumes of 20 microliters to 4 milliliters. The device has a fibrous filter with a pore size of less than about 3 microns, and is coated with a mixture of mannitol and plasma fraction protein. The coating causes the cellular fraction to be trapped by the small pores, leaving the cellular fraction intact on the fibrous filter while the acellular fraction passes through the filter for collection in unaltered form from the serum sample collection chamber. The method used by this product is useful to NASA for blood analysis on manned space missions.

  14. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... submit the name, address, and phone number of its United States agent as part of its initial and updated... States agent's name, address, or phone number to FDA within 10-business days of the change....

  15. Fueling an Economy with Industrial Training.

    ERIC Educational Resources Information Center

    Raven, Helen C.; LeFiles, Diane C.

    1979-01-01

    A postsecondary training program in various aspects of coal mining has been established in western Maryland through community college credit and noncredit courses leading to a certificate or associate degree for mine employees and others. Maryland's industrial training program includes state aid to industry to provide needed job skills training.…

  16. Developing Industry Linkages: Learning from Practice.

    ERIC Educational Resources Information Center

    Misko, Josie

    Linkages between Australia's vocational education and training (VET) and technical and further education (TAFE) sectors and industry were examined through 13 case studies involving a variety of industrial sectors in South Australia, New South Wales, and Victoria. Special attention was paid to the processes established by school clusters to develop…

  17. Blood circulation under weightless conditions

    NASA Technical Reports Server (NTRS)

    Kasyan, I. I.; Kopanev, V. I.; Yazdovskiy, V. I.

    1975-01-01

    Biomedical data obtained on men and animals during weightlessness conditions establish instabilities in pulse rate and blood circulation that smooth out in proportion to adaptation to the weightless condition. The unusual slowness of recovery of pulse rate to initial values after space flight stress is attributed to biological simulation of hormonal shifts and discharge of humoral substances into the blood that prevent a rapid recovery of some biological indicators to initial values.

  18. Population control II: The population establishment today.

    PubMed

    Hartmann, B

    1997-01-01

    Although population assistance represents a relatively small share of official development assistance, it influences many other aspects of development planning. The organizations that comprise the population establishment have a common purpose--the reduction of population growth in the Third World--but they are not homogeneous and sometimes have conflicting goals and strategies. National governments, multilateral agencies, nongovernmental organizations, foundations, academic centers, and pressure groups all contribute to creating and sustaining what has become a virtual population control industry. Through scholarships, travel grants, awards, and favorable publicity, Third World elites have been encouraged to join the population establishment. The World Bank, the U.S. Agency for International Development, and the U.N. Fund for Population Activities have pursued explicit strategies for pressuring Third World governments to design and implement population policies, most recently in Africa.

  19. 29 CFR 570.109 - “Establishment situated in the United States”.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... producing establishments are industrial plants, mines, quarries, and the like. The producing establishment... establishment. No hard and fast rule can be laid down which will fix the area of all establishments. Accordingly.... This is the case, for example, where a large shipyard contains the plants of a number of subcontractors...

  20. 29 CFR 570.109 - “Establishment situated in the United States”.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... producing establishments are industrial plants, mines, quarries, and the like. The producing establishment... establishment. No hard and fast rule can be laid down which will fix the area of all establishments. Accordingly.... This is the case, for example, where a large shipyard contains the plants of a number of subcontractors...

  1. 29 CFR 570.109 - “Establishment situated in the United States”.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... producing establishments are industrial plants, mines, quarries, and the like. The producing establishment... establishment. No hard and fast rule can be laid down which will fix the area of all establishments. Accordingly.... This is the case, for example, where a large shipyard contains the plants of a number of subcontractors...

  2. 29 CFR 570.109 - “Establishment situated in the United States”.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... producing establishments are industrial plants, mines, quarries, and the like. The producing establishment... establishment. No hard and fast rule can be laid down which will fix the area of all establishments. Accordingly.... This is the case, for example, where a large shipyard contains the plants of a number of subcontractors...

  3. 29 CFR 570.109 - “Establishment situated in the United States”.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... producing establishments are industrial plants, mines, quarries, and the like. The producing establishment... establishment. No hard and fast rule can be laid down which will fix the area of all establishments. Accordingly.... This is the case, for example, where a large shipyard contains the plants of a number of subcontractors...

  4. Blood Disorders

    MedlinePlus

    ... public health approach is integrating public health-related information systems, such as disease registries. By collaborating with health ... has established the Community Counts program to collect information about ... data systems also can provide data for evaluating comprehensive patient ...

  5. Blood Tests

    MedlinePlus

    ... as the kidneys, liver, thyroid, and heart—are working Diagnose diseases and conditions such as cancer, HIV/AIDS, diabetes, anemia (uh-NEE-me-eh), and coronary heart disease Find out whether you have risk factors ... taking are working Assess how well your blood is clotting Overview ...

  6. Industrial ammonia gassing

    PubMed Central

    Walton, M.

    1973-01-01

    Walton, M. (1972).British Journal of Industrial Medicine,30, 78-86. Industrial ammonia gassing. Seven cases of ammonia gassing are described with follow-up for five years of the six survivors and the post-mortem findings of the fatal case. All the survivors attributed continuing symptoms to the gassing. The study failed to demonstrate permanent ill effects in the one case of mild exposure. Of the more serious cases one has stopped smoking and taken up physical training teaching. He now has above average lung function. Two serious cases who continued to smoke have the lung function abnormalities expected from their smoking. In the other two seriously exposed cases, who also continued to smoke, there is a persistent reduction in ventilation and gas transfer which seems to be due to the ammonia gassing. The post-mortem findings in the fatal case showed acute congestion and oedema of the mucosa of the respiratory tract, the bronchial walls being stripped of their lining epithelium and the alveoli stuffed with red blood cells and oedema fluid. Images PMID:4685304

  7. Operation of the DREO (Defence Research Establishment Ottawa) Synthetic Aperture Radar Optical Correlator.

    DTIC Science & Technology

    1983-09-01

    Defence Research Establishment Ottawa and Canadian industry . This instrument was designed to correlate interferograms produced by synthetic aperture radar...incoherents. These de doctorat , Universit& Laval, 1975. 5. C.J. Brochu and N. Brousseau, Simulation of a Synthetic Aperture Radar Optical Correlator using a...optical correlator developed by the Defence Research Establishment Ottawa and Canadian industry . This instrument was designed to correlate

  8. 29 CFR 779.321 - Inapplicability of “retail concept” to some types of sales or services of an eligible establishment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Since there is no retail concept in the construction industry, gross receipts from construction... construction and the distribution of goods are entirely dissimilar activities performed in industries... the industry usage or classification. (b) An establishment is, therefore, not automatically exempt...

  9. 29 CFR 779.321 - Inapplicability of “retail concept” to some types of sales or services of an eligible establishment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Since there is no retail concept in the construction industry, gross receipts from construction... construction and the distribution of goods are entirely dissimilar activities performed in industries... the industry usage or classification. (b) An establishment is, therefore, not automatically exempt...

  10. 29 CFR 779.321 - Inapplicability of “retail concept” to some types of sales or services of an eligible establishment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Since there is no retail concept in the construction industry, gross receipts from construction... construction and the distribution of goods are entirely dissimilar activities performed in industries... the industry usage or classification. (b) An establishment is, therefore, not automatically exempt...

  11. 29 CFR 779.321 - Inapplicability of “retail concept” to some types of sales or services of an eligible establishment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Since there is no retail concept in the construction industry, gross receipts from construction... construction and the distribution of goods are entirely dissimilar activities performed in industries... the industry usage or classification. (b) An establishment is, therefore, not automatically exempt...

  12. 29 CFR 779.321 - Inapplicability of “retail concept” to some types of sales or services of an eligible establishment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Since there is no retail concept in the construction industry, gross receipts from construction... construction and the distribution of goods are entirely dissimilar activities performed in industries... the industry usage or classification. (b) An establishment is, therefore, not automatically exempt...

  13. [A comparative analysis of occupational risk in industry employees based on concentrations of some elements in teeth and body fluids].

    PubMed

    Poczatek, Michał; Machoy, Zygmunt; Gutowska, Izabela; Chlubek, Dariusz

    2004-01-01

    Work safety and hygiene is a set of basic measures to protect workers from the negative effects of manufacturing processes. So far, numerous procedures for assessment of occupational health risk have been described. We measured the concentrations of some elements in teeth and body fluids of employees working in three different industries with an established production profile: Zakłady Naprawcze Taboru Kolejowego (repairs of rail vehicles), Philips Lighting Poland (production of lighting systems) and Metalplast (build ing furbishing factory). Different technologies were in place at each of these plants. Basing on laboratory analyses, the risk of exposure to chemical substances was evaluated. The study material included 100 extracted teeth, as well as body fluid samples (saliva, urine and blood) collected during routine health checks. Whenever possible, concentrations of the following elements were measured: calcium, magnesium, fluorine, phosphorus in the form of phosphates, potassium, sodium, iron, zinc, copper, cadmium, and lead. Metal elements were measured spectrophotometrically (ASA), fluorine with an ion-selective electrode, and phosphates with a colorimetric method. We found that concentrations of the elements in teeth and body fluids differed depending on the industry. For teeth, statistically significant differences applied to magnesium, phosphates, zinc, sodium, and potassium. In body fluids, statistically significant differences were found for calcium (blood and urine), magnesium (blood, urine and saliva), zinc (blood, urine and saliva), iron, lead and copper (urine). In conclusion, our findings may be helpful for monitoring safety at work in industrial plants.

  14. Industrial Productivity

    NASA Technical Reports Server (NTRS)

    1977-01-01

    NASTRAN is an offshoot of the computer-design technique used in construction of airplanes and spacecraft. [n this technique engineers create a mathematical model of the aeronautical or space vehicle and "fly" it on the ground by means of computer simulation. The technique enables them to study performance and structural behavior of a number of different designs before settling on the final configuration and proceeding with construction. From this base of aerospace experience, NASA-Goddard developed the NASTRAN general purpose computer program, which offers an exceptionally wide range of analytic capability with regard to structures. NASTRAN has been applied to autos, trucks, railroad cars, ships, nuclear power reactors, steam turbines, bridges, and office buildings. NASA-Langley provides program maintenance services regarded as vital by many NASTRAN users. NASTRAN is essentially a predictive tool. It takes an electronic look at a computerire$.dedgn and reports how the structure will react under a great many different conditions. It can, for example, note areas where high stress levels will occur-potential failure points that need strengthening. Conversely, it can identify over-designed areas where weight and material might be saved safely. NASTRAN can tell how pipes stand up under strong fluid flow, how metals are affected by high temperatures, how a building will fare in an earthquake or how powerful winds will cause a bridge to oscillate. NASTRAN analysis is quick and inexpensive. It minimizes trial-and-error in the design process and makes possible better, safe, lighter structures affording large-scale savings in development time and materials. Some examples of the broad utility NASTRAN is finding among industrial firms are shown on these pages.

  15. Genotoxicity of sludges, wastewater and effluents from three different industries.

    PubMed

    Krishnamurthi, K; Saravana Devi, S; Hengstler, J G; Hermes, Matthias; Kumar, Koel; Dutta, Dipanwita; Muhil Vannan, S; Subin, T S; Yadav, R R; Chakrabarti, T

    2008-12-01

    Many surface waters in Europe, Asia and South America have been reported to be contaminated with genotoxic substances. Therefore, it is important to establish strategies for identification of the most critical sources. In this study, we used a battery of four genotoxicity assays namely chromosomal aberration, DNA strand break, DNA laddering and P53 accumulation tests in mononuclear blood cells. Before cleaning of wastewater high levels of genotoxic contamination could be observed. For instance, we observed an increase in chromosomal aberrations from 2.6 +/- 1.1 (aberrant cells in %; control), to 33.6 +/- 6.6 in a petrochemical plant, 29.4 +/- 3.3 in a petroleum refinery and 14.4 +/- 1.8 in a coke plant of steel industry. A good correlation between the four assays was found. The most sensitive and reproducible results were obtained with the chromosomal aberration assay. Interestingly, clear differences in the efficiency of wastewater cleaning in three different treatment plants were observed. The first and second treatment plants in petrochemical industry and coke plant of steel industry completely eliminated genotoxicity of the wastewater. However, the third plant in petroleum refinery could achieve a reduction in genotoxicity but significant genotoxic contaminations were still present. In conclusion, our battery of genotoxicity tests allows the identification of critical sources contributing to contamination of surface waters.

  16. CBC blood test

    MedlinePlus

    ... blood cells ( WBC count ) The total amount of hemoglobin in the blood The fraction of the blood ... following measurements: Average red blood cell size (MCV) Hemoglobin amount per red blood cell (MCH) The amount ...

  17. Investigation on artificial blood or substitute blood replace the natural blood

    PubMed Central

    Keyhanian, Sh; Ebrahimifard, M; Zandi, M

    2014-01-01

    Blood is a liquid tissue in which dissolved with abundant chemical factors and millions of different cells The reduction of unwanted side effects, especially diseases that emerge through blood such as HIV and hepatitis, has a significant role for modern medicine of transfusion and transplantation. The issues and costs of human blood collection and storage, direct this procedure towards the use of alternatives blood. Two important research fields of this area were oxygen carriers based on hemoglobin and perfluoro chemicals. While they do not have the same quality as the blood cell products, the oxygen carrier solutions have potential clinical and non-clinical applications. The result showed that these products can reach to the body tissues easier than normal red blood cells, and can control the oxygen directly. The final aim of transfusion is to establish a transfusion system with no side effects, and the fact that oxygen carrier artificial blood has this property. The article attempts to step towards solving some problems of blood transfusion through describing the properties of artificial blood alternatives PMID:25002929

  18. Investigation on artificial blood or substitute blood replace the natural blood.

    PubMed

    Keyhanian, Sh; Ebrahimifard, M; Zandi, M

    2014-01-01

    Blood is a liquid tissue in which dissolved with abundant chemical factors and millions of different cells The reduction of unwanted side effects, especially diseases that emerge through blood such as HIV and hepatitis, has a significant role for modern medicine of transfusion and transplantation. The issues and costs of human blood collection and storage, direct this procedure towards the use of alternatives blood. Two important research fields of this area were oxygen carriers based on hemoglobin and perfluoro chemicals. While they do not have the same quality as the blood cell products, the oxygen carrier solutions have potential clinical and non-clinical applications. The result showed that these products can reach to the body tissues easier than normal red blood cells, and can control the oxygen directly. The final aim of transfusion is to establish a transfusion system with no side effects, and the fact that oxygen carrier artificial blood has this property. The article attempts to step towards solving some problems of blood transfusion through describing the properties of artificial blood alternatives.

  19. Rheology of embryonic avian blood.

    PubMed

    Al-Roubaie, Sarah; Jahnsen, Espen D; Mohammed, Masud; Henderson-Toth, Caitlin; Jones, Elizabeth A V

    2011-12-01

    Shear stress, a mechanical force created by blood flow, is known to affect the developing cardiovascular system. Shear stress is a function of both shear rate and viscosity. While established techniques for measuring shear rate in embryos have been developed, the viscosity of embryonic blood has never been known but always assumed to be like adult blood. Blood is a non-Newtonian fluid, where the relationship between shear rate and shear stress is nonlinear. In this work, we analyzed the non-Newtonian behavior of embryonic chicken blood using a microviscometer and present the apparent viscosity at different hematocrits, different shear rates, and at different stages during development from 4 days (Hamburger-Hamilton stage 22) to 8 days (about Hamburger-Hamilton stage 34) of incubation. We chose the chicken embryo since it has become a common animal model for studying hemodynamics in the developing cardiovascular system. We found that the hematocrit increases with the stage of development. The viscosity of embryonic avian blood in all developmental stages studied was shear rate dependent and behaved in a non-Newtonian manner similar to that of adult blood. The range of shear rates and hematocrits at which non-Newtonian behavior was observed is, however, outside the physiological range for the larger vessels of the embryo. Under low shear stress conditions, the spherical nucleated blood cells that make up embryonic blood formed into small aggregates of cells. We found that the apparent blood viscosity decreases at a given hematocrit during embryonic development, not due to changes in protein composition of the plasma but possibly due to the changes in cellular composition of embryonic blood. This decrease in apparent viscosity was only visible at high hematocrit. At physiological values of hematocrit, embryonic blood viscosity did not change significantly with the stage of development.

  20. Artifical Blood.

    PubMed

    Goorha, Y K; Deb, Prabal; Chatterjee, T; Dhot, P S; Prasad, R S

    2003-01-01

    Elimination of unwanted side-effects, especially transfusion-transmitted diseases (HIV and hepatitis) and leucocyte-mediated allosensitisation, is an important goal of modern transfusion medicine. The problems and high cost factor involved in collecting and storing human blood and the pending world-wide shortages are the other driving forces contributing towards the development of blood substitutes. Two major areas of research in this endeavour are haemoglobin-based oxygen carriers (HBOCs) and perfluorochemicals. Even though they do not qualify as perfect red blood cell substitutes, these 'oxygen carrying solutions' have many potential clinical and non clinical usages. These can reach tissues more easily than normal red cells and can deliver oxygen directly. These are not without adverse effects, and extensive clinical trials are being conducted to test their safety and efficacy. New understandings on the mode of action of these products will help to define their utility and application. Only after successful clinical trials can they be used for patient management, after approval by the FDA.

  1. [Blood eosinophilia in the tropics].

    PubMed

    Savini, H; Simon, F

    2013-05-01

    Blood eosinophilia is an abnormal laboratory finding defined by the presence of more than 0.5 G/L of eosinophils. The most common causes for it in tropical zones are various forms of helminthic infections. Medication side effects and atopic phenomena are less frequent than in the industrialized countries. It can also result from a systemic condition. Its discovery requires a pragmatic etiological investigation, trial treatments, and follow-up based on screening for chronic blood diseases and for serious visceral injuries linked to chronic tissue eosinophil toxicity.

  2. Proteomic Analysis of Menstrual Blood*

    PubMed Central

    Yang, Heyi; Zhou, Bo; Prinz, Mechthild; Siegel, Donald

    2012-01-01

    Menstruation is the expulsion of the endometrial lining of the uterus following a nearly month long preparation for embryo implantation and pregnancy. Increasingly, the health of the endometrium is being recognized as a critical factor in female fertility, and proteomes and transcriptomes from endometrial biopsies at different stages of the menstrual cycle have been studied for both diagnostic and therapeutic purposes (1 Kao, L. C., et al. 2003 Endocrinology 144, 2870–2881; Strowitzki, Tet al. 2006 Hum. Reprod. Update 12, 617–630; DeSouza, L., et al. 2005 Proteomics 5, 270–281). Disorders of the uterus ranging from benign to malignant tumors, as well as endometriosis, can cause abnormal menstrual bleeding and are frequently diagnosed through endometrial biopsy (Strowitzki, Tet al. 2006 Hum. Reprod. Update 12, 617–630; Ferenczy, A. 2003 Maturitas 45, 1–14). Yet the proteome of menstrual blood, an easily available noninvasive source of endometrial tissue, has yet to be examined for possible causes or diagnoses of infertility or endometrial pathology. This study employed five different methods to define the menstrual blood proteome. A total of 1061 proteins were identified, 361 were found by at least two methods and 678 were identified by at least two peptides. When the menstrual blood proteome was compared with those of circulating blood (1774 proteins) and vaginal fluid (823 proteins), 385 proteins were found unique to menstrual blood. Gene ontology analysis and evaluation of these specific menstrual blood proteins identified pathways consistent with the processes of the normal endometrial cycle. Several of the proteins unique to menstrual blood suggest that extramedullary uterine hematopoiesis or parenchymal hemoglobin synthesis may be occurring in late endometrial tissue. The establishment of a normal menstrual blood proteome is necessary for the evaluation of its usefulness as a diagnostic tool for infertility and uterine pathologies. Identification of

  3. Industrial technology modernization (ITM) program

    NASA Astrophysics Data System (ADS)

    Hawk, M. R.

    The Industrial Technology Modernization (ITM) program represents an F-16 technology modernization program for subcontractors. The original F-16 Technology Modernization Program was conceived to establish a manufacturing environment which would minimize the manufacturing costs of F-16 aircraft. The success of this program led to the expansion of the concept of modernization to include key F-16 subcontractors. The phases in the ITM program structure are related to analysis and conceptual design, detailed factory modernization designs, and the implementation of factory medernization. Attention is also given to aspects of program documentation, and details regarding the contracting mechanics established for initiating subcontractor technology modernization.

  4. 29 CFR 779.357 - May qualify as exempt 13(a)(2) establishments; classification of coal sales.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... establishment's sales are recognized as retail in the particular industry, sales of coal to the consumer from a... the general manufacturing or industrial process such as the use in laundries, bakeries, nurseries...

  5. 29 CFR 779.357 - May qualify as exempt 13(a)(2) establishments; classification of coal sales.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... establishment's sales are recognized as retail in the particular industry, sales of coal to the consumer from a... the general manufacturing or industrial process such as the use in laundries, bakeries, nurseries...

  6. Industry liaison section implementation plan

    NASA Technical Reports Server (NTRS)

    Lakowske, Stephen

    1990-01-01

    The Industry Liaison Section is a new function of the Army/NASA Aircrew-Aircraft Integration (AAAI) Program that is intended to bridge an existing gap between Government developers (including contractors) and outside organizations who are potential users of products and services developed by the AAAI Program. Currently in its sixth year, the Program is experiencing considerable pull from industry and other government organizations to disseminate products. Since the AAAI Program's charter is exploratory and research in nature, and satisfying proper dissemination requirements is in conflict with the rapid prototyping approach utilized by the design team, the AAAI Program has elected to create an Industry Liaison Section (ILS) to serve as the Program's technology transfer focal point. The process by which the ILS may be established, organized and managed is described, including the baseline organizational structure, duties, functions, authority, responsibilities, relations and policies and procedures relevant to the conduct of the ILS.

  7. A Testing Service for Industry

    NASA Technical Reports Server (NTRS)

    1994-01-01

    A small isolated NASA facility provides assistance to industry in the design, testing, and operation of oxygen systems. White Sands Test Facility (WSTF) was originally established to test rocket propulsion systems for the Apollo program. The facility's role was later expanded into testing characterization, flammability and toxicity characteristics of materials. Its materials and components test methods were adopted by the American society for Testing and Materials. When research and testing results became known, industry requested assistance, and in 1980, NASA authorized WSTF to open its facility to private firms, a valuable service, as oxygen systems testing is often too expensive and too hazardous for many companies. Today, some of the best known American industries utilize White Sands testing capabilities.

  8. [Comparative analysis of semiotic shifts, established by LCS of blood plasma from random samples of studied subjects from the zone of the Chernobyl accident, "Ural Radiation Trace", and collaborators from St. Petersburg Institute of Nuclear Physics of the Russian Academy of Sciences].

    PubMed

    Ternovoĭ, K S; Selezneva, T N; Akleev, A V; Pashkov, I A; Noskin, L A; Klopov, N V; Noskin, V A; Starodub, N F

    1998-01-01

    Using the developed "semiotic" classifier of laser correlation spectra of blood plasma the authors have carried out the verification of organism states of patients from the zone of Chernobyl accident, "Ural radiation trace" and collaborators from Sanct-Petersbourg Institute of Nuclear Physics. An analysis of results obtained using accidental selections which differed as to the character of radiation injury evidences for high informativeness of "semiotic" classifier of laser correlation spectra of blood plasma.

  9. Professors and Industry Meet

    ERIC Educational Resources Information Center

    Sheriff, Robert E.

    1974-01-01

    Describes backgrounds of geophysics graduates that are desired for employment by industry. Also listed are areas in which industry could help universities concerning the development of programs to meet the future manpower needs in industry. (BR)

  10. Chemicals Industry Vision

    SciTech Connect

    none,

    1996-12-01

    Chemical industry leaders articulated a long-term vision for the industry, its markets, and its technology in the groundbreaking 1996 document Technology Vision 2020 - The U.S. Chemical Industry. (PDF 310 KB).

  11. Professors and Industry Meet

    ERIC Educational Resources Information Center

    Sheriff, Robert E.

    1974-01-01

    Describes backgrounds of geophysics graduates that are desired for employment by industry. Also listed are areas in which industry could help universities concerning the development of programs to meet the future manpower needs in industry. (BR)

  12. Iatrogenic Blood-borne Viral Infections in Refugee Children from War and Transition Zones

    PubMed Central

    2013-01-01

    Pediatric infectious disease clinicians in industrialized countries may encounter iatrogenically transmitted HIV, hepatitis B virus, and hepatitis C virus infections in refugee children from Central Asia, Southeast Asia, and sub-Saharan Africa. The consequences of political collapse and/or civil war—work migration, prostitution, intravenous drug use, defective public health resources, and poor access to good medical care—all contribute to the spread of blood-borne viruses. Inadequate infection control practices by medical establishments can lead to iatrogenic infection of children. Summaries of 4 cases in refugee children in Australia are a salient reminder of this problem. PMID:23739597

  13. Iatrogenic blood-borne viral infections in refugee children from war and transition zones.

    PubMed

    Goldwater, Paul N

    2013-06-01

    Pediatric infectious disease clinicians in industrialized countries may encounter iatrogenically transmitted HIV, hepatitis B virus, and hepatitis C virus infections in refugee children from Central Asia, Southeast Asia, and sub-Saharan Africa. The consequences of political collapse and/or civil war-work migration, prostitution, intravenous drug use, defective public health resources, and poor access to good medical care-all contribute to the spread of blood-borne viruses. Inadequate infection control practices by medical establishments can lead to iatrogenic infection of children. Summaries of 4 cases in refugee children in Australia are a salient reminder of this problem.

  14. Globalisation and blood safety.

    PubMed

    Farrugia, Albert

    2009-05-01

    Globalisation may be viewed as the growing interdependence of countries worldwide through the increasing volume and variety of cross-border transactions in goods and services, and also through the more rapid and widespread diffusion of technology. Globalisation is not just an economic phenomenon, although it is frequently described as such, but includes commerce, disease and travel, and immigration, and as such it affects blood safety and supply in various ways. The relatively short travel times offered by modern aviation can result in the rapid spread of blood-borne pathogens before measures to counteract transmission can be put in place; this would have happened with SARS if the basic life cycle of the SARS virus included an asymptomatic viraemia. This risk can be amplified by ecological factors which effect the spread of these pathogens once they are transferred to a naïve ecosystem, as happened with West Nile Virus (WNV) in North America. The rationalization and contraction of the plasma products industry may be viewed as one aspect of globalisation imposed by the remorseless inevitability of the market; the effect of this development on the safety and supply of products has yet to be seen, but the oversight and assurance of a shrinking number of players will present particular challenges. Similarly, the monopolization of technology, through patent enforcement which puts access beyond the reach of developing countries, can have an effect on blood safety. The challenges presented to blood safety by globalisation are heightening the tensions between the traditional focus on the product safety - zero risk paradigm and the need to view the delivery of safe blood as an integrated process. As an illustration of this tension, donor deferral measures imposed by globalisation-induced risks such as vCJD and WNV have resulted in the loss of the safest and most committed portion of the blood donor population in many Western countries, leading to an increased risk to

  15. 75 FR 14564 - Dairy Industry Advisory Committee; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... Farm Service Agency Dairy Industry Advisory Committee; Public Meeting AGENCY: Farm Service Agency, USDA..., the Farm Service Agency (FSA) announces a public meeting of the newly established Dairy Industry... 2009, USDA established the Dairy Committee. The Dairy Committee will review the issues of farm...

  16. 76 FR 5779 - Fruit and Vegetable Industry Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... Agricultural Marketing Service Fruit and Vegetable Industry Advisory Committee AGENCY: Agricultural Marketing... interested parties that the Agricultural Marketing Service (AMS) will hold a Fruit and Vegetable Industry...) established the Committee to examine the full spectrum of issues faced by the fruit and vegetable industry...

  17. 75 FR 8038 - Fruit and Vegetable Industry Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... Agricultural Marketing Service Fruit and Vegetable Industry Advisory Committee AGENCY: Agricultural Marketing... interested parties that the Agricultural Marketing Service (AMS) will hold a Fruit and Vegetable Industry...) established the Committee to examine the full spectrum of issues faced by the fruit and vegetable industry...

  18. 75 FR 47535 - Fruit and Vegetable Industry Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Agricultural Marketing Service Fruit and Vegetable Industry Advisory Committee AGENCY: Agricultural Marketing... interested parties that the Agricultural Marketing Service (AMS) will hold a Fruit and Vegetable Industry...) established the Committee to examine the full spectrum of issues faced by the fruit and vegetable industry...

  19. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Commercial and industrial... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore. ...

  20. A Cooperative M.S. Program in Industrial Chemistry.

    ERIC Educational Resources Information Center

    Mattson, Guy; Gupton, John

    1983-01-01

    A well-established graduate program in industrial chemistry with a considerable degree of academic-industrial interaction is described. Students in the program undertake joint, industrially related research projects on campus (University of Central Florida) and at cooperating companies. Program objectives and eight required courses are discussed.…