Science.gov

Sample records for industry blood establishment

  1. 78 FR 18353 - Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... the Federal Register of October 29, 2007 (72 FR 61171), FDA announced the availability of the draft... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Blood Establishment Computer System... ``Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility'' dated...

  2. 75 FR 75483 - Guidance for Industry: Recommendations for Blood Establishments: Training of Back-Up Personnel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ... guidance, the H1N1 influenza pandemic has waned in the United States and disruptions in the blood supply..., and Preservation of the Blood Supply in Response to Pandemic (H1N1) 2009 Virus'' dated November 2009... in Response to Pandemic (H1N1) 2009 Virus'' (November 2009). At that time, we anticipated that...

  3. Industry-Oriented Doctorate Established.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1982

    1982-01-01

    Describes an industry-related program at the University of Texas (Arlington) leading to a Doctorate of Science in Applied Chemistry. The program requires an industrial internship and a dissertation based on research involving both the university's chemistry faculty and chemists in industry. (SK)

  4. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... certified under the Clinical Laboratory Improvement Amendments of 1988 (42 U.S.C. 263a) and 42 CFR part 493... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Exemptions for blood product establishments. 607... BLOOD AND BLOOD PRODUCTS Exemptions § 607.65 Exemptions for blood product establishments. The...

  5. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... certified under the Clinical Laboratory Improvement Amendments of 1988 (42 U.S.C. 263a) and 42 CFR part 493... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Exemptions for blood product establishments. 607... BLOOD AND BLOOD PRODUCTS Exemptions § 607.65 Exemptions for blood product establishments. The...

  6. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... certified under the Clinical Laboratory Improvement Amendments of 1988 (42 U.S.C. 263a) and 42 CFR part 493... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Exemptions for blood product establishments. 607... BLOOD AND BLOOD PRODUCTS Exemptions § 607.65 Exemptions for blood product establishments. The...

  7. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... certified under the Clinical Laboratory Improvement Amendments of 1988 (42 U.S.C. 263a) and 42 CFR part 493... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Exemptions for blood product establishments. 607... BLOOD AND BLOOD PRODUCTS Exemptions § 607.65 Exemptions for blood product establishments. The...

  8. [Blood trace elements content in adolescents in an industrial town].

    PubMed

    Namazbaeva, Z I; Amanzhol, I A; Shibuchikova, Zh B; Sabirov, Zh B; Zhumabekova, S Zh

    2013-01-01

    A cohort blind study of blood trace elements content in children-adolescents aged 14-16 years old, residing in an industrial town, where large industrial enterprises of ferrous and non-ferrous metallurgy have been functioning for long periods, has been performed There was established a lack of vital important element selenium in the blood, that causes the accumulation of toxic metals, cadmium and mercury.

  9. Establishing Ergonomics in Industrially Developing Countries

    SciTech Connect

    Stewart, K; Silverstein, B; Kiefer, M

    2005-08-29

    The introduction of ergonomics is an ongoing effort in industrially developing countries and will ultimately require an organized, programmatic approach spanning several countries and organizations. Our preliminary efforts with our partner countries of Viet Nam, Thailand, and Nicaragua have demonstrated that a one-time course is just the first step in a series of necessary events to provide skills and create an infrastructure that will have lasting impact for the host country. To facilitate that any sort of training has a lasting impact, it is recommended that host countries establish a 'contract' with class participants and the guest instructors for at least one follow-up visit so instructors can see the progress and support the participants in current and future efforts. With repeated exchanges, the class participants can become the 'in country experts' and the next generation of ergonomic trainers. Additionally, providing participants with an easy to use hazard assessment tool and methods for evaluating the financial impact of the project (cost/benefit analysis) will assist increase the likelihood of success and establish a foundation for future projects. In the future, developing trade and regionally/culturally specific 'ergonomics toolkits' can help promote broader implementation, especially where training resources may be limited.

  10. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for...

  11. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for...

  12. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for...

  13. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for...

  14. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for...

  15. 21 CFR 607.65 - Exemptions for blood product establishments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the Clinical Laboratory Improvement Amendments of 1988 (42 U.S.C. 263a) and 42 CFR part 493 or has met... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Exemptions for blood product establishments. 607.65... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD...

  16. A rational framework for production decision making in blood establishments.

    PubMed

    Ramoa, Augusto; Maia, Salomé; Lourenço, Anália

    2012-07-24

    SAD_BaSe is a blood bank data analysis software, created to assist in the management of blood donations and the blood production chain in blood establishments. In particular, the system keeps track of several collection and production indicators, enables the definition of collection and production strategies, and the measurement of quality indicators required by the Quality Management System regulating the general operation of blood establishments. This paper describes the general scenario of blood establishments and its main requirements in terms of data management and analysis. It presents the architecture of SAD_BaSe and identifies its main contributions. Specifically, it brings forward the generation of customized reports driven by decision making needs and the use of data mining techniques in the analysis of donor suspensions and donation discards.

  17. [THE CHOLINESTERASE OF BLOOD SERUM IN WORKERS OF INDUSTRIAL ENTERPRISE].

    PubMed

    Radamishina, G G; Bakirov, A B; Gimranova, G G; Valeeva, O V

    2015-08-01

    The biochemical study of activity of serum cholinesterase in workers of industrial enterprise was carried out on the example of petrochemical industry. The indicators of average activity of enzyme and prevalence of indicators going beyond limits of reference values were analyzed depending on manufacturing-labor experience, profession and diseases established in workers. The main diseases, professional and labor experience groups were identified where activity of cholinesterase significantly changes. The impact of labor experience and profession on level of activity ofenzyme in blood serum is demonstrated. PMID:26596043

  18. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Inspection of establishment registrations and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  19. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  20. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  1. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  2. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  3. 21 CFR 607.21 - Times for establishment registration and blood product listing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Times for establishment registration and blood... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.21 Times for establishment registration and blood product listing. The owner or operator of...

  4. Ovine blood: establishment of a list of reference values relevant for blood coagulation in sheep.

    PubMed

    Wilhelmi, Mathias H; Tiede, Andreas; Teebken, Omke E; Bisdas, Theodosios; Haverich, Axel; Mischke, Reinhard

    2012-01-01

    Ovine animal models are widely used to conduct preclinical studies, e.g., to evaluate cardiovascular prostheses intended to be applied in man. However, although analyzed in many of those studies, information about ovine blood reference values is scanty. The aim of this study is to establish a reference list of ovine blood parameters relevant for blood coagulation. A cohort of 47 mature ewes was evaluated. Parameters comprised the following: cells and cellular components-platelet, red, and white cell counts (including subsets), hemoglobin (Hb), hematocrit (HCT), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV), and MCH concentration (MCHC); global tests of coagulation-prothrombin time (Quick's time) and activated partial thromboplastin time (aPTT); and parameters relevant for blood coagulation-fibrinogen, antithrombin (AT), and von Willebrand Factor. After explorative data analysis, a list of ovine reference values was established. Interestingly, a comparison with human reference values revealed some interspecies differences between sheep and man, i.e., much higher ovine ranges for some cell counts (neutrophils, lymphocytes, basophils, eosinophils, and platelets) but lower values for some other parameters (Hb, HCT, MCV, MCH, AT, and Quick's test). We established a reference list of ovine blood count and blood coagulation parameters. Because of some peculiarities of the ovine blood, this list may have implications for the interpretation of experimental data.

  5. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  6. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  7. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  8. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  9. 21 CFR 207.7 - Establishment registration and product listing for human blood and blood products and for medical...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... human blood and blood products and for medical devices. 207.7 Section 207.7 Food and Drugs FOOD AND DRUG... product listing for human blood and blood products and for medical devices. (a) Owners and operators of human blood and blood product establishments shall register and list their products with the Center...

  10. Establishing an Elementary Industrial Arts Program. Monograph 9.

    ERIC Educational Resources Information Center

    White, Michael R., Ed.

    This monograph provides various audiences with background material necessary to the successful establishment of an elementary school industrial arts (IA) program. Chapter 1 discusses needs of children in respect to activity-based learning and addresses concerns teachers have as they move from print media instruction to an activity-based elementary…

  11. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a)...

  12. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a)...

  13. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  14. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  15. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  16. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a)...

  17. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... blood product listings. 607.37 Section 607.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  18. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... blood product listings. 607.37 Section 607.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  19. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  20. 21 CFR 607.22 - How and where to register establishments and list blood products.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... blood products. 607.22 Section 607.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.22 How and where to register establishments and list blood products. (a) The first registration of...

  1. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a)...

  2. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a)...

  3. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... blood product listings. 607.37 Section 607.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  4. 21 CFR 607.37 - Inspection of establishment registrations and blood product listings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... blood product listings. 607.37 Section 607.37 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.37 Inspection of establishment registrations and blood product listings. (a) A copy of the Form FD-2830...

  5. Sanitizing Rhetorics of the Commercial Blood Plasma Industry.

    ERIC Educational Resources Information Center

    Anderson, Leon; Moser, Christina

    The United States blood plasma industry uses various rhetorics to access donors and markets its products while managing its stigma and potential legal liability. The industry includes both the public "nonprofit" sector and the private, for-profit blood collection and manufacturing businesses owned by pharmaceutical companies that rely on paid…

  6. Establishing Chlamydomonas reinhardtii as an industrial biotechnology host

    PubMed Central

    Scaife, Mark A; Nguyen, Ginnie TDT; Rico, Juan; Lambert, Devinn; Helliwell, Katherine E; Smith, Alison G

    2015-01-01

    Microalgae constitute a diverse group of eukaryotic unicellular organisms that are of interest for pure and applied research. Owing to their natural synthesis of value-added natural products microalgae are emerging as a source of sustainable chemical compounds, proteins and metabolites, including but not limited to those that could replace compounds currently made from fossil fuels. For the model microalga, Chlamydomonas reinhardtii, this has prompted a period of rapid development so that this organism is poised for exploitation as an industrial biotechnology platform. The question now is how best to achieve this? Highly advanced industrial biotechnology systems using bacteria and yeasts were established in a classical metabolic engineering manner over several decades. However, the advent of advanced molecular tools and the rise of synthetic biology provide an opportunity to expedite the development of C. reinhardtii as an industrial biotechnology platform, avoiding the process of incremental improvement. In this review we describe the current status of genetic manipulation of C. reinhardtii for metabolic engineering. We then introduce several concepts that underpin synthetic biology, and show how generic parts are identified and used in a standard manner to achieve predictable outputs. Based on this we suggest that the development of C. reinhardtii as an industrial biotechnology platform can be achieved more efficiently through adoption of a synthetic biology approach. Significance Statement Chlamydomonas reinhardtii offers potential as a host for the production of high value compounds for industrial biotechnology. Synthetic biology provides a mechanism to generate generic, well characterised tools for application in the rational genetic manipulation of organisms: if synthetic biology principles were adopted for manipulation of C. reinhardtii, development of this microalga as an industrial biotechnology platform would be expedited. PMID:25641561

  7. Establishing Chlamydomonas reinhardtii as an industrial biotechnology host.

    PubMed

    Scaife, Mark A; Nguyen, Ginnie T D T; Rico, Juan; Lambert, Devinn; Helliwell, Katherine E; Smith, Alison G

    2015-05-01

    Microalgae constitute a diverse group of eukaryotic unicellular organisms that are of interest for pure and applied research. Owing to their natural synthesis of value-added natural products microalgae are emerging as a source of sustainable chemical compounds, proteins and metabolites, including but not limited to those that could replace compounds currently made from fossil fuels. For the model microalga, Chlamydomonas reinhardtii, this has prompted a period of rapid development so that this organism is poised for exploitation as an industrial biotechnology platform. The question now is how best to achieve this? Highly advanced industrial biotechnology systems using bacteria and yeasts were established in a classical metabolic engineering manner over several decades. However, the advent of advanced molecular tools and the rise of synthetic biology provide an opportunity to expedite the development of C. reinhardtii as an industrial biotechnology platform, avoiding the process of incremental improvement. In this review we describe the current status of genetic manipulation of C. reinhardtii for metabolic engineering. We then introduce several concepts that underpin synthetic biology, and show how generic parts are identified and used in a standard manner to achieve predictable outputs. Based on this we suggest that the development of C. reinhardtii as an industrial biotechnology platform can be achieved more efficiently through adoption of a synthetic biology approach.

  8. [How do I assess requirement of a blood bank and its kind for a healthcare establishment?].

    PubMed

    Lafeuillade, B; Tixier, A; Bliem, C; Meyer, F

    2014-12-01

    Access to blood components is required for healthcare establishments, particularly for emergency situation and hospital blood bank was often a response to this requirement. However, the complexity of regulation and economic pressures lead healthcare establishment to review regularly their need for a blood bank. This assessment requires analysis of need for transfusions in terms of delay, quantity and clinical situations to which they must respond. When a blood bank is required, three kinds could be under consideration: emergency blood bank, intermediate blood bank and issuance blood bank. According to requirements, advantages and disadvantages of each kind, healthcare establishments would select the most suitable one.

  9. Establishment of outgrowth endothelial cells from peripheral blood.

    PubMed

    Martin-Ramirez, Javier; Hofman, Menno; van den Biggelaar, Maartje; Hebbel, Robert P; Voorberg, Jan

    2012-09-01

    Blood outgrowth endothelial cells (BOECs) are important tools when investigating diagnostic and therapeutic approaches for vascular disease. In this protocol, mononuclear cells are isolated from peripheral blood and plated on type I collagen at ∼135,000 cells per cm(2) in endothelial cell differentiation medium. On average, 0.34 colonies of endothelial cells per milliliter of blood can be obtained. Colonies of endothelial cells become visible after 14-28 d. Upon confluence, these rapidly expanding colonies can be passaged and have been shown to propagate up to 10(18)-fold. Isolated BOECs are phenotypically similar to vascular endothelial cells, as revealed by their cobblestone morphology, the presence of endothelial cell-specific Weibel-Palade bodies and the expression of endothelial cell markers such as VE-cadherin. The protocol presented here also provides a particularly useful tool for the ex vivo assessment of endothelial cell function from patients with different vascular abnormalities. PMID:22918388

  10. From research to industry — The establishment of a radiation processing industry in South Africa

    NASA Astrophysics Data System (ADS)

    Plessis, T. A. Du; Stevens, RCB

    In the late sixties the South African Atomic Energy Board in pursuing its objectives to promote the peaceful application of nuclear energy in general, established a research group with the specific purpose of investigating and developing radiation processing as a new technique. During the early years it was realised that the economic and technological facets of establishing a new industry were equally important and, in addition to fundamental research, strong emphasis was placed on the necessity of marketing this new technology. Although the initial emphasis was put on gamma sterilization, and today still forms the backbone of the radiation processing industry, the promising fields of polymer modification and food irradiation hold a lot of promise in the radiation processing industry. Following ten years of successfully introducing and providing a radiation service, the South African Atomic Energy Board in 1980 decided to transfer its service to the private sector. These developments in South Africa are a good sample of how a small country, through initial government envolvement, can acquire a sophisticated new private industry.

  11. 7 CFR 1260.113 - Established national nonprofit industry-governed organizations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Established national nonprofit industry-governed... national nonprofit industry-governed organizations. Established national nonprofit industry-governed... directors representing the cattle or beef industry on a national basis; and (c) Were active and...

  12. 7 CFR 1260.113 - Established national nonprofit industry-governed organizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Established national nonprofit industry-governed... national nonprofit industry-governed organizations. Established national nonprofit industry-governed... directors representing the cattle or beef industry on a national basis; and (c) Have been active and...

  13. 7 CFR 1260.113 - Established national nonprofit industry-governed organizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Established national nonprofit industry-governed... national nonprofit industry-governed organizations. Established national nonprofit industry-governed... directors representing the cattle or beef industry on a national basis; and (c) Were active and...

  14. 7 CFR 1260.113 - Established national nonprofit industry-governed organizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Established national nonprofit industry-governed... national nonprofit industry-governed organizations. Established national nonprofit industry-governed... directors representing the cattle or beef industry on a national basis; and (c) Were active and...

  15. 7 CFR 1260.113 - Established national nonprofit industry-governed organizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Established national nonprofit industry-governed... national nonprofit industry-governed organizations. Established national nonprofit industry-governed... directors representing the cattle or beef industry on a national basis; and (c) Have been active and...

  16. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Blood meal, blood albumin, intestines... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use; importations permitted subject to restrictions. Blood meal, blood albumin, bone meal, intestines, or other...

  17. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Blood meal, blood albumin, intestines... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use; importations permitted subject to restrictions. Blood meal, blood albumin, bone meal, intestines, or other...

  18. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Blood meal, blood albumin, intestines... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use; importations permitted subject to restrictions. Blood meal, blood albumin, bone meal, intestines, or other...

  19. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Blood meal, blood albumin, intestines... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use; importations permitted subject to restrictions. Blood meal, blood albumin, bone meal, intestines, or other...

  20. Proposed policies and procedures for the establishment of a cord blood bank.

    PubMed

    McCullough, J; Clay, M E; Fautsch, S; Noreen, H; Segall, M; Perry, E; Stroncek, D

    1994-01-01

    To carry out cord blood transplants from allogeneic unrelated donors, cord blood stem cell banks must be established. This report proposed the policies and procedures that can be used to establish cord blood banks. The areas covered include donor consent and suitability criteria; infectious and genetic disease testing; collection, processing, and preservation of the cord blood; retention of specimens for special testing; confidentiality; documentation and record keeping; establishment of a quality control program; and related regulatory issues. There are no technologic impediments to establishing cord blood banks. Agreement on some standard policies and procedures would facilitate exchange of cord blood stem cells among transplant centers and should increase the number of transplants that can be done.

  1. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  2. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  3. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  4. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  5. 21 CFR 607.7 - Establishment registration and product listing of blood banks and other firms manufacturing human...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... blood banks and other firms manufacturing human blood and blood products. 607.7 Section 607.7 Food and... ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS General Provisions § 607.7 Establishment registration and product listing of blood banks and other...

  6. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Partial exemption for establishments in certain industries... Partial exemption for establishments in certain industries. (a) Basic requirement. (1) If your business establishment is classified in a specific low hazard retail, service, finance, insurance or real estate...

  7. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Partial exemption for establishments in certain industries... Partial exemption for establishments in certain industries. (a) Basic requirement. (1) If your business establishment is classified in a specific low hazard retail, service, finance, insurance or real estate...

  8. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Partial exemption for establishments in certain industries... Partial exemption for establishments in certain industries. (a) Basic requirement. (1) If your business establishment is classified in a specific low hazard retail, service, finance, insurance or real estate...

  9. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use...

  10. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use...

  11. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use...

  12. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use...

  13. 9 CFR 95.15 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Blood meal, blood albumin, intestines..., blood albumin, intestines, and other animal byproducts for industrial use; requirements for unrestricted entry. Blood meal, blood albumin, bone meal, intestines, or other animal materials intended for use...

  14. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Notification of registrant; blood product... PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.35 Notification of registrant; blood product establishment registration number and...

  15. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Notification of registrant; blood product... PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.35 Notification of registrant; blood product establishment registration number and...

  16. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Notification of registrant; blood product... PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.35 Notification of registrant; blood product establishment registration number and...

  17. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Notification of registrant; blood product... PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.35 Notification of registrant; blood product establishment registration number and...

  18. 21 CFR 607.35 - Notification of registrant; blood product establishment registration number and NDC Labeler Code.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Notification of registrant; blood product... PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.35 Notification of registrant; blood product establishment registration number and...

  19. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., insurance or real estate industries (SICs 52-89)? Yes, business establishments classified in agriculture... required to keep records, while others may be exempt. (3) How do I determine the Standard Industrial Classification code for my company or for individual establishments? You determine your Standard...

  20. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... establishment is classified in a specific low hazard retail, service, finance, insurance or real estate industry... industry classification exemption apply only to business establishments in the retail, services, finance... President, Office of Management and Budget. You may contact your nearest OSHA office or State agency...

  1. 9 CFR 95.16 - Blood meal, blood albumin, intestines, and other animal byproducts for industrial use...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Blood meal, blood albumin, intestines... AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SANITARY CONTROL OF... Blood meal, blood albumin, intestines, and other animal byproducts for industrial use;...

  2. Family planning programs in industrial establishments: an operations research study.

    PubMed

    Cabigon, J; Magsino, E

    1993-01-01

    An operations research study in the Philippines sought to uncover determinants of the sustainability of employment-based family planning (FP) programs offered in industrial settings where the Philippine Center for Population and Development (PCPD) had provided assistance in implementing Responsible Parenthood/FP-Maternal Health (RP/FP-MH) Programs. Qualitative data were gathered through observations and interviews with the target population and with company management and program implementers. Based on this study, the following recommendations were made: 1) training outputs should be echoed to employees immediately; 2) RP/FP-MCH team members should be recruited from each level of the work force; 3) an appropriate IEC (information, education, and communication) strategy should be devised to respond to the short time-frame in which employees can participate; 4) team-building training should be incorporated as a regular activity early in the contract period; 5) sectoral targeting should be used within a given company; 6) training programs should be designed for each of the three types of team members and should overlap the basic topics; 7) teamwork and mutual assistance should be encouraged; 8) the work of the teams should be rewarded; 9) commendable initiative of liaison officers should be sustained; 10) representatives of the PCPD should maintain a close relationship with the teams through PCPD staff visits to the companies; 11) management requires more intensive orientation on the RP/FP-MH program; 12) PCPD support should be withdrawn gradually until the companies are able to sustain the program themselves; 13) it may be helpful to require a company to meet rigid criteria in order to take part in the PCPD project; 14) OR should be continued; and 15) the concept and practice of quality of care should be introduced to service delivery and training of staff and motivators.

  3. Quality management in European screening laboratories in blood establishments: A view of current approaches and trends.

    PubMed

    Pereira, Paulo; Westgard, James O; Encarnação, Pedro; Seghatchian, Jerard; de Sousa, Gracinda

    2015-04-01

    The screening laboratory has a critical role in the post-transfusion safety. The success of its targets and efficiency depends on the management system used. Even though the European Union directive 2002/98/EC requires a quality management system in blood establishments, its requirements for screening laboratories are generic. Complementary approaches are needed to implement a quality management system focused on screening laboratories. This article briefly discusses the current good manufacturing practices and good laboratory practices, as well as the trends in quality management system standards. ISO 9001 is widely accepted in some European Union blood establishments as the quality management standard, however this is not synonymous of its successful application. The ISO "risk-based thinking" is interrelated with the quality risk-management process of the EuBIS "Standards and criteria for the inspection of blood establishments". ISO 15189 should be the next step on the quality assurance of a screening laboratory, since it is focused on medical laboratory. To standardize the quality management systems in blood establishments' screening laboratories, new national and European claims focused on technical requirements following ISO 15189 is needed.

  4. Quality management in European screening laboratories in blood establishments: A view of current approaches and trends.

    PubMed

    Pereira, Paulo; Westgard, James O; Encarnação, Pedro; Seghatchian, Jerard; de Sousa, Gracinda

    2015-04-01

    The screening laboratory has a critical role in the post-transfusion safety. The success of its targets and efficiency depends on the management system used. Even though the European Union directive 2002/98/EC requires a quality management system in blood establishments, its requirements for screening laboratories are generic. Complementary approaches are needed to implement a quality management system focused on screening laboratories. This article briefly discusses the current good manufacturing practices and good laboratory practices, as well as the trends in quality management system standards. ISO 9001 is widely accepted in some European Union blood establishments as the quality management standard, however this is not synonymous of its successful application. The ISO "risk-based thinking" is interrelated with the quality risk-management process of the EuBIS "Standards and criteria for the inspection of blood establishments". ISO 15189 should be the next step on the quality assurance of a screening laboratory, since it is focused on medical laboratory. To standardize the quality management systems in blood establishments' screening laboratories, new national and European claims focused on technical requirements following ISO 15189 is needed. PMID:25765135

  5. Importance of monitoring family members in establishing sources and pathways of lead in blood.

    PubMed

    Gulson, B L; Mizon, K J; Korsch, M J; Howarth, D

    1996-10-11

    High precision lead isotope measurements were undertaken to establish the sources and pathways in blood and environmental samples of five families from the Broken Hill lead mining community, New South Wales, Australia. The five families were selected from 27 families investigated to illustrate the different sources and pathways of lead into blood and the importance of monitoring the whole family. The results illustrate that although the major source of lead is from the orebody, paint and petrol can be significant contributors to both house dust and blood leads. The results also show that the sources and pathways can be from the father's occupation and hence monitoring of families is important, especially in high risk locations. In two cases, the elevated blood leads in the children did not derive from their current residence but from other residences in the community.

  6. Establishment of a Graduate Certificate Program in Biobased Industrial Products – Final Technical Report

    SciTech Connect

    John R. Schlup

    2005-11-04

    A certificate of graduate studies in Biobased Industrial Products is to be established at Kansas State University (KSU) along with the development of a similar program at Pittsburg State University, Pittsburg, KS. At KSU, the program of study will be coordinated through the steering committee of the Agricultural Products Utilization Forum (APUF); the certificate of graduate studies will be awarded through the Graduate School of Kansas State University. This certificate will establish an interdisciplinary program of study that will: (1) ensure participating students receive a broad education in several disciplines related to Biobased Industrial Products, (2) provide a documented course of study for students preferring a freestanding certificate program, and (3) provide a paradigm shift in student awareness away from petroleum-based feedstocks to the utilization of renewable resources for fuels and chemical feedstocks. The academic program described herein will accomplish this goal by: (1) providing exposure to several academic disciplines key to Biobased Industrial Products; (2) improving university/industry collaboration through an external advisory board, distance learning opportunities, and student internships; (3) expanding the disciplines represented on the students' supervisory committee; (4) establishing a seminar series on Biobased Industrial Products that draws upon expert speakers representing several disciplines; and (5) increasing collaboration between disciplines. Numerous research programs emphasizing Biobased Industrial Products currently exist at KSU and PSU. The certificate of graduate studies, the emphasis on interdisciplinary collaboration within the students? thesis research, the proposed seminar series, and formation of an industrial advisory board will: (1) provide an interdisciplinary academic experience that spans several departments, four colleges, four research centers, and two universities; (2) tangibly promote collaboration between KSU

  7. Establishing traceability of photometric absorbance values for accurate measurements of the haemoglobin concentration in blood

    NASA Astrophysics Data System (ADS)

    Witt, K.; Wolf, H. U.; Heuck, C.; Kammel, M.; Kummrow, A.; Neukammer, J.

    2013-10-01

    Haemoglobin concentration in blood is one of the most frequently measured analytes in laboratory medicine. Reference and routine methods for the determination of the haemoglobin concentration in blood are based on the conversion of haeme, haemoglobin and haemiglobin species into uniform end products. The total haemoglobin concentration in blood is measured using the absorbance of the reaction products. Traceable absorbance measurement values on the highest metrological level are a prerequisite for the calibration and evaluation of procedures with respect to their suitability for routine measurements and their potential as reference measurement procedures. For this purpose, we describe a procedure to establish traceability of spectral absorbance measurements for the haemiglobincyanide (HiCN) method and for the alkaline haematin detergent (AHD) method. The latter is characterized by a higher stability of the reaction product. In addition, the toxic hazard of cyanide, which binds to the iron ion of the haem group and thus inhibits the oxygen transport, is avoided. Traceability is established at different wavelengths by applying total least-squares analysis to derive the conventional quantity values for the absorbance from the measured values. Extrapolation and interpolation are applied to get access to the spectral regions required to characterize the Q-absorption bands of the HiCN and AHD methods, respectively. For absorbance values between 0.3 and 1.8, the contributions of absorbance measurements to the total expanded uncertainties (95% level of confidence) of absorbance measurements range from 1% to 0.4%.

  8. Court upholds $405,000 award against blood banking industry.

    PubMed

    1995-06-30

    The New Jersey Superior Court has ruled that the American Association of Blood Banks (AABB), the nation's largest blood bank trade group, was negligent during the early 1980s when it recommended that blood banks not screen and test donors to reduce the chance of HIV contamination of the nation's blood supply. [Name removed], who received HIV-contaminated blood in 1984 as a result of a transfusion at St. Joseph's Hospital in Paterson, sued and reached out-of-court settlements with his doctors and the Bergen Community Blood Center, which provided the blood. Only the AABB suit proceeded to trial, with the jury finding that one-third of the damages were attributable to the AABB's actions. In 1983, the Centers for Disease Control and Prevention (CDC) suggested that blood banks might reduce the risk of AIDS entering the blood supply by using the surrogate hepatitis B test. The AABB, the American Red Cross, and the Council of Community Blood Centers recommended against testing, saying that evidence of transmission by blood was inconclusive and unproven. In March 1985, the AABB adopted the ELISA test. This is the first time the AABB has been held responsible; the AABB said it may appeal the decision. The court disagreed with AABB's claim that it was immune from liability because it was a charity, saying it also performs a critical governance function in respect of the operation of blood banks. The decision puts considerable liability for the U.S. cases of HIV contracted through tainted blood transfusions on the AABB.

  9. Divergent effects of flavone acetic acid on established versus developing tumour blood flow.

    PubMed Central

    Mahadevan, V.; Hart, I. R.

    1991-01-01

    Flavone Acetic Acid (FAA) exerts much of its effect by reducing tumour blood flow. Previous studies on FAA-induced changes in blood flow have used established tumours with a functional microvasculature. Using radioactive Xenon(133Xe) clearance to monitor local blood flow we show that the effects of FAA are dependent on the presence of this functional microvasculature with no evidence that FAA inhibits the actual development of tumour microcirculation. Thus, administration of multiple doses of FAA around the time of tumour cell injection failed to diminish t1/2 values of 133Xe (e.g. t1/2 16 min for FAA vs 14 min for saline controls at 10 days) or to affect tumour volumes (5.55 +/- 0.06 cm3 in FAA-treated animals vs 5.7 +/- 1.3 cm3 in controls at 25 days). In marked contrast a single dose of FAA (200 mg kg-1 body weight) 2 weeks after tumour cell injection dramatically extended t1/2 times (47 min for FAA vs 7 min for controls; P less than 0.001) and significantly reduced tumour burden. This effect is specific for tumour microvasculature and is not directed simply at new vessels since a similar treatment of animals with implanted-sponge-induced granulation tissue had no effect on t1/2 times (6.8 +/- 1.1 min for FAA at 200 mg kg-1 vs 7.2 +/- 1.0 min for saline-treated controls. PMID:1712621

  10. [Preparation of bovine hemoglobin-loaded nanoparticles used as blood substitutes and establishment of reduction system].

    PubMed

    Zhang, Xiaolan; Yuan, Yuan; Shan, Xiaoqian; Sheng, Yan; Zhao, Jian; Liu, Changsheng

    2008-12-01

    Bovine Hb-loaded nanoparticles with modulated size of pores, for use as blood substitutes, were prepared and a nonenzymatic reduction system including two-step-reduction and process optimization was established to control the metHb level in the present study. After the first-step-reduction procedure was performed, the raw BHb, being oxidized severely, was encapsulated to form nanoparticles by the modified double emulsion method. The binary solvent of dichloromethane (DCM) and acetonitrile (Aci) showed properties such as minimizing Hb oxidation and enlarging the pores of nanopartilces. Based on the size of pores o f nanoparticles evaluated by the diffusion of various substances wi thdifferent molecular weights, reducing agents such as ascorbic acid and glutathione present in the plasma were selected to perform the second-step-reduction, i. e. to further reduce the metHb in nanoparticles. The metHb level was reduced from over 90% in the raw materials to 1.25% by the two-step-reduction and controlled preparation; this is near the level of native blood, possessing the ability of carrying/releasing oxygen.

  11. Genotyping of 22 blood group antigen polymorphisms and establishing a national recipient registry in the Korean population.

    PubMed

    Hong, Yun Ji; Chung, Yousun; Hwang, Sang Mee; Park, Jeong Su; Kwon, Jeong-Ran; Choi, Young Sill; Kim, Jun Nyun; Lee, Dong Han; Kwon, So-Yong; Cho, Nam-Sun; Song, Eun Young; Park, Kyoung Un; Song, Junghan; Han, Kyou Sup

    2016-05-01

    It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewpoint and estimated the demand for specific antigen-negative blood from a patient viewpoint. Our data will aid the establishment of a Rare Blood Program in Korea (KRBP). RBC genotyping of 419 blood donors was performed using a Lifecodes RBC/RBC-R typing kit (Immucor, Norcross, GA). A national recipient registry website has been established. Each hospital-based blood bank voluntarily enters data on antibodies detected and identified and the outcomes of specific antigen testing. We calculated the availabilities of specific antigen-negative blood components based on these registry data and predicted the prevalence of RBC antigens via RBC genotyping. The prevalences of various RBC antigens in the D-negative population were determined for the first time, and the Cartwright, Scianna, Dombrock, Colton, Landsteiner-Wiener, Cromer, and Knops blood group systems were identified. The availabilities of specific antigen-negative units differed when calculations were based on serotyping or genotyping, especially in the D-negative group. Data on the prevalences of various blood antigens are essential for estimating the availabilities of blood components that are appropriate for use by patients expressing relevant antibodies. Then, blood banks would be able to efficiently supply safe blood products. PMID:27021300

  12. First optical education center in Japan established by cooperation between academia and industry

    NASA Astrophysics Data System (ADS)

    Yatagai, Toyohiko

    2014-07-01

    At the present of the 21st century, optical technology became what must be in our life. If there is no optical technology, we cannot use optical equipments such as the camera, microscopes, DVD, LEDs and laser diodes (LDs). Optics is also the leading part in the most advanced scientific field. It is clear that the organization which does education and research is required in such a very important area. Unfortunately, there was no such organization in Japan. The education and research of light have been individually done in various faculties of universities, various research institutes, and many companies. However, our country is now placed in severer surroundings, such as the globalization of our living, the accelerated competition in research and development. This is one of the reasons why Utsunomiya University has established Center for Optical Research and Education (CORE) in 2007. To contribute to optical technology and further development of optical industry, "Center for Optical Research and Education (CORE), Utsunomiya University" promotes education and research in the field of the optical science and technology cooperatively with industry, academia and the government. Currently, 6 full professors, 21 cooperative professors, 2 visiting professors and 7 post-doctoral researchers and about 40 students are joined with CORE. Many research projects with industries, the local government of Tochigi as well as Japanese government. Optical Innovation Center has established in CORE by supporting of Japan Science and Technology Agency in 2011 to develop advanced optical technologies for local companies.

  13. Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells

    PubMed Central

    Kurita, Ryo; Suda, Noriko; Sudo, Kazuhiro; Miharada, Kenichi; Hiroyama, Takashi; Miyoshi, Hiroyuki; Tani, Kenzaburo; Nakamura, Yukio

    2013-01-01

    Transfusion of red blood cells (RBCs) is a standard and indispensable therapy in current clinical practice. In vitro production of RBCs offers a potential means to overcome a shortage of transfusable RBCs in some clinical situations and also to provide a source of cells free from possible infection or contamination by microorganisms. Thus, in vitro production of RBCs may become a standard procedure in the future. We previously reported the successful establishment of immortalized mouse erythroid progenitor cell lines that were able to produce mature RBCs very efficiently. Here, we have developed a reliable protocol for establishing immortalized human erythroid progenitor cell lines that are able to produce enucleated RBCs. These immortalized cell lines produce functional hemoglobin and express erythroid-specific markers, and these markers are upregulated following induction of differentiation in vitro. Most importantly, these immortalized cell lines all produce enucleated RBCs after induction of differentiation in vitro, although the efficiency of producing enucleated RBCs remains to be improved further. To the best of our knowledge, this is the first demonstration of the feasibility of using immortalized human erythroid progenitor cell lines as an ex vivo source for production of enucleated RBCs. PMID:23533656

  14. 76 FR 20633 - Announcement of Meeting to Explore Feasibility of Establishing a NIST/Industry Consortium on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Establishing a NIST/Industry Consortium on Neutron Measurements for Soft Materials Manufacturing AGENCY... industry interest in creating a NIST/industry consortium focused on advanced neutron-based probes for soft materials. The goals of such a consortium would include the development of neutron-based measurements...

  15. 75 FR 73107 - Guidance for Industry and Food and Drug Administration Staff; Blood Lancet Labeling; Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff... ``Guidance for Industry and Food and Drug Administration Staff; Blood Lancet Labeling.'' FDA is issuing this guidance with labeling recommendations because of concerns that both healthcare providers and patients...

  16. Application of blood cadmium determination to industry using a punched disc technique.

    PubMed Central

    Cernik, A A; Sayers, M P

    1975-01-01

    A paper disc flameless atomic absorption spectroscopy (AAS) method is described for the determination of cadmium (Cd) in blood, enabling difficulties in sample preparation to be minimized. By control of the ashing step the matrix can be removed without loss of cadmium. Problems with the fast signal response during atomization can be met by spectral band width and temperature control. At the 106 pg level (471 nmol Cd/1 blood; 5-3 mug/100 ml) the relative standard deviation (RSD) was 0-06. Results in four industrial situations are reported. This description of the method should facilitate further investigation of its application to industry using capillary or venous blood. PMID:1131342

  17. The food and drug administration is now preparing to establish tighter performance requirements for blood glucose monitors.

    PubMed

    Klonoff, David C

    2010-05-01

    On March 16 and 17, 2010, the Food and Drug Administration (FDA) presented a public meeting about blood glucose monitoring at the Gaithersberg Hilton Hotel. The meeting was intended to present expert opinions and solicit input from the public about whether to develop new regulatory policies for blood glucose monitors. The meeting was divided into three sections: (1) Clinical Accuracy Requirements for Blood Glucose Monitors, (2) Interferences and Limitations of Blood Glucose Monitors, and (3) Tight Glycemic Control. Many officials from the Center for Devices and Radiologic Health and the Office of In Vitro Diagnostic Devices, which are the parts of FDA that regulate approval of blood glucose monitors, either spoke on the agenda or attended in the audience. Approximately 300 people attended; they were mostly clinicians (such as adult endocrinologists, pediatric endocrinologists, internists, clinical chemists, intensivists, surgeons, nurses, and diabetes educators) or industry officials from companies involved in glucose monitoring, pharmaceutical products, data analysis, or regulatory consulting. PMID:20513313

  18. Methods for establishing a surveillance system for cardiovascular diseases in Indian industrial populations.

    PubMed Central

    Reddy, K. S.; Prabhakaran, D.; Chaturvedi, V.; Jeemon, P.; Thankappan, K. R.; Ramakrishnan, L.; Mohan, B. V. M.; Pandav, C. S.; Ahmed, F. U.; Joshi, P. P.; Meera, R.; Amin, R. B.; Ahuja, R. C.; Das, M. S.; Jaison, T. M.

    2006-01-01

    OBJECTIVE: To establish a surveillance network for cardiovascular diseases (CVD) risk factors in industrial settings and estimate the risk factor burden using standardized tools. METHODS: We conducted a baseline cross-sectional survey (as part of a CVD surveillance programme) of industrial populations from 10 companies across India, situated in close proximity to medical colleges that served as study centres. The study subjects were employees (selected by age and sex stratified random sampling) and their family members. Information on behavioural, clinical and biochemical determinants was obtained through standardized methods (questionnaires, clinical measurements and biochemical analysis). Data collation and analyses were done at the national coordinating centre. FINDINGS: We report the prevalence of CVD risk factors among individuals aged 20-69 years (n = 19 973 for the questionnaire survey, n = 10 442 for biochemical investigations); mean age was 40 years. The overall prevalence of most risk factors was high, with 50.9% of men and 51.9% of women being overweight, central obesity was observed among 30.9% of men and 32.8% of women, and 40.2% of men and 14.9% of women reported current tobacco use. Self-reported prevalence of diabetes (5.3%) and hypertension (10.9%) was lower than when measured clinically and biochemically (10.1% and 27.7%, respectively). There was marked heterogeneity in the prevalence of risk factors among the study centres. CONCLUSION: There is a high burden of CVD risk factors among industrial populations across India. The surveillance system can be used as a model for replication in India as well as other developing countries. PMID:16799730

  19. Industrial Sites Project Establishment of Final Action Levels, Rev. No.: 0

    SciTech Connect

    Boehlecke, Robert F.

    2006-02-01

    The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) oversees numerous sites on the Nevada Test Site (NTS) and other locations in the State of Nevada that have been impacted by activities related to the development and testing of nuclear devices and by other activities. NNSA/NSO is responsible for protecting members of the public, including site workers, from harmful exposure to both chemical and radiological contaminants at these sites as they remediate these sites. The Nevada Division of Environmental Protection (NDEP) is the primary state agency responsible for protection of human health and the environment with respect to chemical and radiological wastes. In 1996 the DOE, U.S. Department of Defense, and the State of Nevada entered into an agreement known as the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Appendix VI to the FFACO describes the strategy employed to plan, implement, and complete environmental corrective action activities at NTS and other locations in the state of Nevada. One of the categories of corrective action units (CAUs) is Industrial Sites, which consists of approximately 1,150 locations that may require some level of investigation and corrective action. To evaluate the need for the extent of corrective action at a particular site, NNSA/NSO assesses the potential impacts to receptors by comparing measurements of contaminant concentrations to risk-based (chemical) and dose-based (radionuclide) standards (action levels). Preliminary action levels (PALs) are established as part of the data quality objective (DQO) process, and are presented in one or more FFACO documents generated as part of the corrective action process. This document formally defines and clarifies the NDEP-approved process NNSA/NSO Industrial Sites Project uses to fulfill the requirements of the FFACO and state regulations. This process establishes final action levels (FALs) based on the risk

  20. From Pastoralism to Industrial Antipathy in William Attaway's Blood on the Forge

    ERIC Educational Resources Information Center

    Vaughan, Philip

    1975-01-01

    Asserts that Blood on the Forge, published in 1941 by black novelist, William Attaway, represented a literary achievement in its own right, and at the same time realistically portrayed the transition of a people from a structured, authoritarian, rural existence to an industrialized urban frontier. Attaway rejected traditional forms of agrarianism…

  1. Establishing a public umbilical cord blood stem cell bank for South Africa: an enquiry into public acceptability.

    PubMed

    Meissner-Roloff, Madelein; Pepper, Michael S

    2013-12-01

    South Africa (SA) faces a large unmet need for bone marrow (BM) transplantation, which could be alleviated in part by establishing a public umbilical cord blood stem cell bank (UCB SCB). Umbilical cord blood is an increasingly utilised source of hematopoietic stem cells for BM transplantation in addition to BM or mobilized peripheral blood stem cells. Establishing a public UCB SCB would therefore be a positive step towards improving the quality of health care in SA by providing for an important unmet need. This study takes the form of an enquiry into the acceptability of establishing a public bank through an interview with and questionnaire completed by mothers-to-be in the antenatal clinic of a large public hospital in SA. Initial results are positive, with 85 % of the participants in favour of establishing a public UCB SCB in SA. This initial probe will serve as a model for a more comprehensive national enquiry into public support and acceptability in different clinics, hospitals and provinces in SA. PMID:23943126

  2. Establishing a public umbilical cord blood stem cell bank for South Africa: an enquiry into public acceptability.

    PubMed

    Meissner-Roloff, Madelein; Pepper, Michael S

    2013-12-01

    South Africa (SA) faces a large unmet need for bone marrow (BM) transplantation, which could be alleviated in part by establishing a public umbilical cord blood stem cell bank (UCB SCB). Umbilical cord blood is an increasingly utilised source of hematopoietic stem cells for BM transplantation in addition to BM or mobilized peripheral blood stem cells. Establishing a public UCB SCB would therefore be a positive step towards improving the quality of health care in SA by providing for an important unmet need. This study takes the form of an enquiry into the acceptability of establishing a public bank through an interview with and questionnaire completed by mothers-to-be in the antenatal clinic of a large public hospital in SA. Initial results are positive, with 85 % of the participants in favour of establishing a public UCB SCB in SA. This initial probe will serve as a model for a more comprehensive national enquiry into public support and acceptability in different clinics, hospitals and provinces in SA.

  3. 76 FR 42715 - Quarantine Release Errors in Blood Establishments; Public Workshop

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... workshop has been planned in partnership with the Department of Health and Human Services (HHS) Office of the Assistant Secretary for Health, America's Blood Centers, and AABB. This public workshop will... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH...

  4. Blood

    MedlinePlus

    ... solid part of your blood contains red blood cells, white blood cells, and platelets. Red blood cells (RBC) deliver oxygen from your lungs to your tissues and organs. White blood cells (WBC) fight infection and are part of your ...

  5. University-Industry Partnerships: A Study of How Top American Research Universities Establish and Maintain Successful Partnerships

    ERIC Educational Resources Information Center

    Prigge, George W.; Torraco, Richard J.

    2006-01-01

    This qualitative research study utilized the grounded theory tradition to examine organizational structures and processes in a purposefully selected sample of American universities that have established and maintained partnerships with industry. Institutional leaders from the corporate relations offices from fifteen of the top research…

  6. 76 FR 66040 - Announcement of Meeting To Explore Feasibility of Establishing a NIST/Industry Consortium on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... Establishing a NIST/Industry Consortium on ``Concrete Rheology: Enabling Metrology (CREME)'' AGENCY: National... consortium focused on ``Concrete Rheology: Enabling Metrology (CREME)''. The goal of such a consortium could... consolidation of concrete. This goal would be achieved by developing test methods and models to measure...

  7. [Innovative urology needs innovative pharmaceuticals and technology: new cooperation established between BDU and industry].

    PubMed

    Ex, P; Schroeder, A

    2013-08-01

    For some time now medical care has been confronted with great challenges. New developments in the healthcare system result in new possibilities for cooperation in which the Professional Association of German Urologists (BDU) must participate. This is also true with respect to the Pharmaceutical Market Revision Act (AMNOG). The Industry Advisory Board aims to continuously observe and analyze the healthcare political and medical care political developments in Germany and Europe. The Professional Association has created room for a transparent cooperation with the Industry Advisory Board. The AMNOG which came into effect in 2011 also opened integrated contracts for businesses in the pharmaceutical industry.

  8. [Innovative urology needs innovative pharmaceuticals and technology: new cooperation established between BDU and industry].

    PubMed

    Ex, P; Schroeder, A

    2013-08-01

    For some time now medical care has been confronted with great challenges. New developments in the healthcare system result in new possibilities for cooperation in which the Professional Association of German Urologists (BDU) must participate. This is also true with respect to the Pharmaceutical Market Revision Act (AMNOG). The Industry Advisory Board aims to continuously observe and analyze the healthcare political and medical care political developments in Germany and Europe. The Professional Association has created room for a transparent cooperation with the Industry Advisory Board. The AMNOG which came into effect in 2011 also opened integrated contracts for businesses in the pharmaceutical industry. PMID:23900482

  9. Empirically establishing blood glucose targets to achieve HbA1c goals.

    PubMed

    Wei, Nancy; Zheng, Hui; Nathan, David M

    2014-04-01

    OBJECTIVE To determine the average fasting, postprandial, and bedtime self-monitored blood glucose (SMBG) concentrations associated with specified HbA1c levels using data from the A1c-Derived Average Glucose (ADAG) study. RESEARCH DESIGN AND METHODS The ADAG study was a multicenter observational study that used continuous glucose monitoring and SMBG testing to determine the relationship between mean average glucose and HbA1c. We used the SMBG data from 470 of the ADAG study participants (237 with type 1 diabetes and 147 with type 2 diabetes) to determine the average fasting, premeal, 90-min postmeal, and bedtime blood glucose (BG) for predefined target HbA1c groups between 5.5 and 8.5% (37-69 mmol/mol). t Tests were used to compare mean BG values between type 1 and type 2 diabetes groups. RESULTS The average fasting BG needed to achieve predefined HbA1c target levels of 5.5-6.49% (37-47 mmol/mol), 6.5-6.99% (48-52 mmol/mol), 7.0-7.49% (52-58 mmol/mol), 7.5-7.99% (58-64 mmol/mol), and 8.0-8.5% (64-69 mmol/mol) were 122 mg/dL with 95% CI 117-127, 142 mg/dL (135-150), 152 mg/dL (143-162), 167 mg/dL (157-177), and 178 mg/dL (164-192), respectively. Postmeal BG to achieve the HbA1c level of 6.5-6.99% (48-52 mmol/mol) and 7.0-7.49% (52-58 mmol/mol) were 139 mg/dL (134-144) and 152 mg/dL (147-157), respectively. Bedtime BG was 153 mg/dL (145-161) and 177 mg/dL (166-188), respectively. CONCLUSIONS We have determined the average BG at premeal, postmeal, and bedtime to achieve a variety of HbA1c targets. These results, based on empirical data, will help patients and providers set realistic day-to-day SMBG targets to achieve individualized HbA1c goals.

  10. Establishing an eastern broccoli industry: where are we and where do we need to go?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A Coordinated Agricultural Project (CAP) entitled “Establishing an Eastern Broccoli Industry” has been underway since the fall of 2010 and funded under the USDA Specialty Crop Research Initiative (SCRI), which was established as part of the 2008 Farm Bill. This project has brought together research...

  11. 76 FR 570 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ..., plasma, and blood. These devices are used to aid in the diagnosis of Lyme disease. This document does not... detection of antibodies to Borrelia burgdorferi. These devices are used to aid in the diagnosis of Lyme disease. This draft guidance is not final nor is it in effect at this time. DATES: Although you...

  12. Blood biomonitoring of metals in subjects living near abandoned mining and active industrial areas.

    PubMed

    Madeddu, Roberto; Tolu, Paola; Asara, Yolande; Farace, Cristiano; Forte, Giovanni; Bocca, Beatrice

    2013-07-01

    A human blood biomonitoring campaign to detect the environmental exposure to metals (Cd, Cu, Cr, Mn, Pb and Zn) in 265 subjects was performed in the South-Western part of Sardinia (an Italian island) that is a particular area with a great history of coal and metal mining (Pb/Zn mainly) activities and large industrial structures (as metallurgy). Subjects living near the industrial plant area had geometric means (GM) of blood Cd (0.79 μg/l), Cu (971 μg/l), Mn (12.2 μg/l), and Pb (55.7 μg/l) significantly higher than controls (Cd, 0.47 μg/l; Cu, 900 μg/l; Mn 9.98 μg/l; Pb, 26.5 μg/l) and than people living nearby the past mining sites. Subjects living next to one dismissed mine were statistically higher in blood Cu (GM, 1,022 μg/l) and Pb (GM, 41.4 μg/l) concentrations than controls. No differences were observed in people living in the different mining sites, and this might be related to the decennial disclosure of mines and the adoption of environmental remediation programmes. Some interindividual variables influenced blood biomonitoring data, as smoke and age for Cd, gender for Cu, age, sex and alcohol for Pb, and age for Zn. Moreover, blood metal levels of the whole population were similar to reference values representative of the Sardinian population and acceptably safe according to currently available health guidelines. PMID:23229279

  13. Air Pollution from Industrial Swine Operations and Blood Pressure of Neighboring Residents

    PubMed Central

    Horton, Rachel Avery; Rose, Kathryn M.

    2012-01-01

    Background: Industrial swine operations emit odorant chemicals including ammonia, hydrogen sulfide (H2S), and volatile organic compounds. Malodor and pollutant concentrations have been associated with self-reported stress and altered mood in prior studies. Objectives: We conducted a repeated-measures study of air pollution, stress, and blood pressure in neighbors of swine operations. Methods: For approximately 2 weeks, 101 nonsmoking adult volunteers living near industrial swine operations in 16 neighborhoods in eastern North Carolina sat outdoors for 10 min twice daily at preselected times. Afterward, they reported levels of hog odor on a 9-point scale and measured their blood pressure twice using an automated oscillometric device. During the same 2- to 3-week period, we measured ambient levels of H2S and PM10 at a central location in each neighborhood. Associations between systolic and diastolic blood pressure (SBP and DBP, respectively) and pollutant measures were estimated using fixed-effects (conditional) linear regression with adjustment for time of day. Results: PM10 showed little association with blood pressure. DBP [β (SE)] increased 0.23 (0.08) mmHg per unit of reported hog odor during the 10 min outdoors and 0.12 (0.08) mmHg per 1-ppb increase of H2S concentration in the same hour. SBP increased 0.10 (0.12) mmHg per odor unit and 0.29 (0.12) mmHg per 1-ppb increase of H2S in the same hour. Reported stress was strongly associated with BP; adjustment for stress reduced the odor–DBP association, but the H2S–SBP association changed little. Conclusions: Like noise and other repetitive environmental stressors, malodors may be associated with acute blood pressure increases that could contribute to development of chronic hypertension. PMID:23111006

  14. Blood biomonitoring of metals in subjects living near abandoned mining and active industrial areas.

    PubMed

    Madeddu, Roberto; Tolu, Paola; Asara, Yolande; Farace, Cristiano; Forte, Giovanni; Bocca, Beatrice

    2013-07-01

    A human blood biomonitoring campaign to detect the environmental exposure to metals (Cd, Cu, Cr, Mn, Pb and Zn) in 265 subjects was performed in the South-Western part of Sardinia (an Italian island) that is a particular area with a great history of coal and metal mining (Pb/Zn mainly) activities and large industrial structures (as metallurgy). Subjects living near the industrial plant area had geometric means (GM) of blood Cd (0.79 μg/l), Cu (971 μg/l), Mn (12.2 μg/l), and Pb (55.7 μg/l) significantly higher than controls (Cd, 0.47 μg/l; Cu, 900 μg/l; Mn 9.98 μg/l; Pb, 26.5 μg/l) and than people living nearby the past mining sites. Subjects living next to one dismissed mine were statistically higher in blood Cu (GM, 1,022 μg/l) and Pb (GM, 41.4 μg/l) concentrations than controls. No differences were observed in people living in the different mining sites, and this might be related to the decennial disclosure of mines and the adoption of environmental remediation programmes. Some interindividual variables influenced blood biomonitoring data, as smoke and age for Cd, gender for Cu, age, sex and alcohol for Pb, and age for Zn. Moreover, blood metal levels of the whole population were similar to reference values representative of the Sardinian population and acceptably safe according to currently available health guidelines.

  15. 77 FR 44263 - Establishment of the U.S. Extractive Industries Transparency Initiative Advisory Committee and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    ... and for companies to make parallel disclosures regarding payments. The Committee will serve as the... that would enable the Department of the Interior to make an informed decision regarding meeting the... and authority to make decisions on its behalf. (4) Basic understanding of the extractive industry...

  16. 76 FR 72951 - Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... (74 FR 46433), FDA announced the availability of the draft guidance. Comments on the draft guidance... Differentiation of Human Papillomaviruses; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... Differentiation of Human Papillomaviruses.'' This guidance document provides industry and Agency staff...

  17. Early establishment of hematopoietic chimerism following allogeneic peripheral blood stem cell transplantation in comparison with allogeneic bone marrow transplantation.

    PubMed

    Nakao, S; Zeng, W; Yamazaki, H; Wang, H; Takami, A; Sugimori, N; Miura, Y; Shiobara, S; Matsuda, T; Shinagawa, Y; Harada, M

    1999-04-01

    To characterize the process of the establishment of complete chimerism after allogeneic peripheral blood stem cell transplantation (allo-PBSCT), we determined the origin of leukocytes in peripheral blood (PB) obtained from 23 patients in the very early period after allo-PBSCT using amplification of mini- or microsatellite regions of genomic DNA. Donor-specific alleles were amplified from the PB obtained at day 8 post-transplant for 19 allo-PBSCT patients. Among the 19 patients, 12 showed only donor-specific alleles (complete chimerism) while 7 did both donor and host-specific alleles (mixed chimerism). Although donor specific alleles were amplified in 10 of 12 patients who received allogeneic bone marrow transplantation (allo-BMT) similarly to allo-PBSCT, all of these ten showed mixed chimerism. When the chimeric state was examined in PB samples obtained serially at 2-3-day intervals post-transplant, host-specific alleles in allo-PBSCT patients were not detectable in the PB much earlier than those in allo-BMT patients. These findings indicate that the appearance of donor-derived cells associated with the disappearance of host-derived cells in the circulation occurs earlier after allo-PBSCT as compared with allo-BMT, leading to the rapid establishment of complete chimerism.

  18. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel Morrison; Sharon Elder

    2006-01-24

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the sixth quarterly technical progress report for the SWC. Key activities for this reporting period included: (1) Organized and hosted two technology transfer meetings; (2) Collaborated with the Pennsylvania Oil and Gas Association (POGAM) to host a Natural Gas Outlook conference in Pittsburgh, PA; (3) Provided a SWC presentation at the Interstate Oil and Gas Compact Commission (IOGCC) meeting in Jackson Hole, WY; and (4) Completed and released a stripper well industry documentary entitled: ''Independent Oil: Rediscovering America's Forgotten Wells''.

  19. 76 FR 5386 - Draft Guidance for Industry: Pre-Storage Leukocyte Reduction of Whole Blood and Blood Components...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... same title dated January 2001 (January 31, 2001, 66 FR 8410). The draft guidance, when finalized, will... of Whole Blood and Blood Components Intended for Transfusion; Availability AGENCY: Food and Drug... Blood and Blood Components Intended for Transfusion'' dated January 2011. The draft guidance...

  20. Building healthy communities: establishing health and wellness metrics for use within the real estate industry.

    PubMed

    Trowbridge, Matthew J; Pickell, Sarah Gauche; Pyke, Christopher R; Jutte, Douglas P

    2014-11-01

    It is increasingly well recognized that the design and operation of the communities in which people live, work, learn, and play significantly influence their health. However, within the real estate industry, the health impacts of transportation, community development, and other construction projects, both positive and negative, continue to operate largely as economic externalities: unmeasured, unregulated, and for the most part unconsidered. This lack of transparency limits communities' ability to efficiently advocate for real estate investment that best promotes their health and well-being. It also limits market incentives for innovation within the real estate industry by making it more difficult for developers that successfully target health behaviors and outcomes in their projects to differentiate themselves competitively. In this article we outline the need for actionable, community-relevant, practical, and valuable metrics jointly developed by the health care and real estate sectors to better evaluate and optimize the "performance" of real estate development projects from a population health perspective. Potential templates for implementation, including the successful introduction of sustainability metrics by the green building movement, and preliminary data from selected case-study projects are also discussed.

  1. Genetically modified T cells targeting neovasculature efficiently destroy tumor blood vessels, shrink established solid tumors and increase nanoparticle delivery.

    PubMed

    Fu, Xinping; Rivera, Armando; Tao, Lihua; Zhang, Xiaoliu

    2013-11-15

    Converting T cells into tumor cell killers by grafting them with a chimeric antigen receptor (CAR) has shown promise as a cancer immunotherapeutic. However, the inability of these cells to actively migrate and extravasate into tumor parenchyma has limited their effectiveness in vivo. Here we report the construction of a CAR containing an echistatin as its targeting moiety (eCAR). As echistatin has high binding affinity to αvβ3 integrin that is highly expressed on the surface of endothelial cells of tumor neovasculature, T cells engrafted with eCAR (T-eCAR) can efficiently lyse human umbilical vein endothelial cells and tumor cells that express αvβ3 integrin when tested in vitro. Systemic administration of T-eCAR led to extensive bleeding in tumor tissues with no evidence of damage to blood vessels in normal tissues. Destruction of tumor blood vessels by T-eCAR significantly inhibited the growth of established bulky tumors. Moreover, when T-eCAR was codelivered with nanoparticles in a strategically designed temporal order, it dramatically increased nanoparticle deposition in tumor tissues, pointing to the possibility that it may be used together with nanocarriers to increase their capability to selectively deliver antineoplastic drugs to tumor tissues.

  2. Lead exposure and blood pressure among workers in diverse industrial plants in Kenya.

    PubMed

    Were, Faridah H; Moturi, M Charles; Gottesfeld, P; Wafula, Godfrey A; Kamau, Geoffrey N; Shiundu, Paul M

    2014-01-01

    The study evaluated airborne exposures and blood lead (BPb) levels in 233 production workers at six diverse industrial plants in Kenya. Blood and personal breathing zone air samples were collected and analyzed for lead (Pb) using atomic absorption spectroscopy. Blood pressure (BP) levels were measured using a standard mercury sphygmomanometer. The results indicated mean airborne Pb levels ± standard deviation (SD) as follows: 183.2 ± 53.6 μg/m(3) in battery recycling, 133.5 ± 39.6 μg/m(3) in battery manufacturing, 126.2 ± 39.9 μg/m(3) in scrap metal welding, 76.3 ± 33.2 μg/m(3) in paint manufacturing, 27.3 ± 12.1 μg/m(3) in a leather manufacturing, and 5.5 ± 3.6 μg/m(3) in a pharmaceutical plant. The mean airborne Pb levels exceeded the U.S. Occupational Safety and Health Administration (OSHA) 8-hr time-weighted average (TWA) permissible exposure limit (PEL) for Pb of 50 μg/m(3) in the battery manufacturing, battery recycling, welding, and paint manufacturing plants. Similarly, mean BPb concentrations exceeded the American Conference of Governmental Industrial Hygienists (ACGIH®) biological exposure index (BEI) for Pb of 30 μg/dl. A significant positive association was observed between BPb and breathing zone air Pb (R(2) = 0.73, P < 0.001). Approximately 30% of the production workers (N = 233) were in the hypertensive range with an average systolic and diastolic blood pressure (BP) of 134.7 ± 12.7 mmHg and 86.4 ± 8.9 mmHg, respectively. In the multivariate regression analysis, age, duration of work, airborne Pb and BPb levels were significantly associated (P < 0.05) with a change in BP. We recommend improved engineering controls, work practices, and personal hygiene to reduce Pb exposures. In addition, workers should undergo comprehensive medical surveillance to include BPb and BP testing, and airborne Pb assessments in all industries with significant lead exposures.

  3. Beryllium disease screening in the ceramics industry. Blood lymphocyte test performance and exposure-disease relations.

    PubMed

    Kreiss, K; Wasserman, S; Mroz, M M; Newman, L S

    1993-03-01

    We identified nine new cases of biopsy-confirmed chronic beryllium disease among 505 employees and ex-employees in a company that had manufactured beryllia ceramics from 1958 through 1975. Of tests commonly used in medical surveillance, only a confirmed blood beryllium lymphocyte transformation test had a high positive predictive value for beryllium disease (100%). However, two beryllium disease cases had either a normal or inconsistently abnormal blood test and were identified for diagnostic workup by abnormal chest radiograph. The only risk factor for beryllium disease was beryllium exposure; smoking or allergic history did not affect risk. Degree of beryllium exposure was associated with disease rates, which ranged from 2.9% to 15.8% for beryllia-exposed subgroups. One case of beryllium disease occurred in a "dust-disturber" who did not report past beryllium exposure and who began employment 8 years after commercial beryllia production had stopped. Our data support efforts to prevent beryllium disease by lowering beryllium exposures and to identify subclinical and early disease by broad-based medical surveillance using the blood beryllium lymphocyte test and chest radiograph in beryllium-using industries.

  4. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2003-04-08

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the ninth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) organizing and hosting two fall technology transfer meetings, (2) SWC membership class expansion, and (3) planning the SWC 2003 Spring meeting. In addition, a literature search that focuses on the use of lasers, microwaves, and acoustics for potential stripper well applications continued.

  5. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2005-01-04

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the seventeenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) organizing and hosting the SWC fall technology transfer meetings in Oklahoma City, Oklahoma and State College, Pennsylvania, (2) planning of the upcoming SWC spring proposal meeting, (3) release of the SWC Request-for-proposals (RFP), (4) revision of the SWC By-Laws, and (5) the SWC Executive Council nomination and election for 2005-2006 term members.

  6. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-05-17

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the twelfth quarterly technical progress report for the SWC. Key activities for this reporting period focused on organizing and hosting three fall technology transfer meetings that will be held in Wyoming, Texas, and Pennsylvania. In addition, work has started on developing the 2004 SWC request-for-proposals which will be released during the next reporting period. During this reporting period, the efforts were focused primarily on the organizing the SWC fall technology transfer meetings.

  7. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-12-28

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the sixteenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) exhibit and participate in the Society of Petroleum Engineers (SPE) Regional Meeting in Charleston West Virginia, (2) finalize the organization of the two fall Technology Transfer meetings and (3) initiate the revision of the SWC By-laws.

  8. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel L. Morrison; Sharon L. Elder

    2006-04-21

    The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL) has established a national industry-driven Stripper Well Consortium (SWC) that is focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the seventh quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) Nomination and election of the Executive Council members for the 2006-07 term, (2) Finalize and release the 2006 Request for Proposals (RFP), (3) Invoice and recruit members, (4) Plan for the spring meeting, (5) Improving communication efforts, and (6) Continue distribution of the DVD entitled: ''Independent Oil: Rediscovering American's Forgotten Wells''.

  9. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-12-23

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the fifteenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) hosting the SWC spring proposal meeting in Golden Colorado, (2) planning of the upcoming SWC fall technology transfer meetings, and (3) recruiting the SWC base membership.

  10. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel L. Morrison; Sharon L. Elder

    2006-05-01

    The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL) established a national industry-driven Stripper Well Consortium (SWC) that is focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the eighth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) Organize and host the 2006 Spring Meeting in State College, PA to review and select projects for SWC co-funding; (2) Participation in the 2006 PA CleanEnergy Expo Energy Theater to air the DVD on ''Independent Oil: Rediscovering American's Forgotten Wells''; (3) New member additions; (4) Improving communications; and (5) Planning of the fall technology meetings.

  11. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-05-18

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the fourteenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) organizing the SWC spring meeting in Golden Colorado, (2) planning of the upcoming SWC fall technology transfer meetings, and (3) recruit the SWC base membership.

  12. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-12-28

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the first quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) hosting the SWC spring proposal meeting in Golden Colorado, (2) planning of the upcoming SWC fall technology transfer meetings, and (3) recruiting the SWC base membership.

  13. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2005-02-17

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the third quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) host the State College, PA fall Technology Transfer meeting, (2) revision of the SWC By-laws, (3) the SWC Executive Council nomination and election for 2005-2006 term members, and (4) finalizing the plans for the Spring Proposal Meeting in San Antonio, Texas.

  14. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2005-01-03

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the second quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) exhibit and participate in the Society of Petroleum Engineers (SPE) Regional Meeting in Charleston WV, (2) host the SWC fall technology transfer meeting in Oklahoma City, OK and finalize the organization of the State College, PA fall Technology Transfer meeting, and (3) initiate the revision of the SWC By-laws.

  15. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel L. Morrison

    2005-08-26

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the eighteenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) prepare presentation for the 16th Annual Oil Recovery Conference in Wichita, Kansas, (2) continued working on the SWC technical bulletin ''Keeping the Home Wells Flowing: Helping Small Independent Oil and Gas Producers Develop New Technology Solutions'', (3) continue efforts on the Public Broadcast of Independent Oil: Rediscovering America's Forgotten Wells, and (4) continue efforts to recruit SWC members.

  16. An Approach to Industrial Stormwater Benchmarks: Establishing and Using Site-Specific Threshold Criteria at Lawrence Livermore National Laboratory

    SciTech Connect

    Campbell, C G; Mathews, S

    2006-09-07

    Current regulatory schemes use generic or industrial sector specific benchmarks to evaluate the quality of industrial stormwater discharges. While benchmarks can be a useful tool for facility stormwater managers in evaluating the quality stormwater runoff, benchmarks typically do not take into account site-specific conditions, such as: soil chemistry, atmospheric deposition, seasonal changes in water source, and upstream land use. Failing to account for these factors may lead to unnecessary costs to trace a source of natural variation, or potentially missing a significant local water quality problem. Site-specific water quality thresholds, established upon the statistical evaluation of historic data take into account these factors, are a better tool for the direct evaluation of runoff quality, and a more cost-effective trigger to investigate anomalous results. Lawrence Livermore National Laboratory (LLNL), a federal facility, established stormwater monitoring programs to comply with the requirements of the industrial stormwater permit and Department of Energy orders, which require the evaluation of the impact of effluent discharges on the environment. LLNL recognized the need to create a tool to evaluate and manage stormwater quality that would allow analysts to identify trends in stormwater quality and recognize anomalous results so that trace-back and corrective actions could be initiated. LLNL created the site-specific water quality threshold tool to better understand the nature of the stormwater influent and effluent, to establish a technical basis for determining when facility operations might be impacting the quality of stormwater discharges, and to provide ''action levels'' to initiate follow-up to analytical results. The threshold criteria were based on a statistical analysis of the historic stormwater monitoring data and a review of relevant water quality objectives.

  17. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2001-06-28

    The Pennsylvania State University, under contract to the US Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the US petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the first quarterly technical progress report for the SWC. The SWC is in its infancy; however, interest from the petroleum and natural gas industry has grown substantially during this reporting period. As of December 31, 2000, nineteen members have joined the consortium and several other companies have expressed interest. During the last three months, efforts were focused on the development of the necessary infrastructure and membership base to begin the consortium technology development activities. These efforts included: (1) preparing a draft constitution and bylaws, (2) developing draft membership application forms, (3) developing an intellectual property statement, (4) providing overview presentations to trade association meetings, and (5) marketing the consortium individually to potential members. These activities are discussed in further detail in this first quarterly technical progress report.

  18. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-05-10

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the tenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) release of the 2003 request-for-proposal (RFP), (2) planning the spring SWC meeting in Pearl River New York, and (3) tentatively plan the SWC 2003 fall technology transfer meetings. During this reporting period, the efforts were focused primarily on the organizing and hosting the fall technology transfer meetings. Simultaneously, administrative issues such as modifying the SWC Constitution and By-Laws and creating a block membership tier to promote further industrial involvement were areas of concentration. The SWC is poised to enter its third year with a growing, diversifying membership.

  19. Pilot social feasibility study for the establishment of a public human umbilical cord blood stem cell bank in South Africa.

    PubMed

    Meissner-Roloff, Madelein; Young, Wendy; Rangaka, Isabella; Lombaard, Hennie; Dhai, Ames; Tsotsi, Norma; Pepper, Michael S

    2012-12-01

    There is a large unmet need in South Africa for bone marrow transplantation. Umbilical cord blood (UCB) is an important source of stem cells for the treatment of haematological and non-haematological diseases. Access to the two existing private umbilical cord blood stem cell banks (UCB SCBs) in South Africa is limited to individuals that can afford it, which further aggravates the ever increasing divide between families from different socio-economic classes. The problem is compounded by a severe global shortage of genetically compatible samples, representative of the South African demographics. Establishing a public human UCB SCB in South Africa would provide more South Africans with access to previously unavailable treatment in the form of affordable, genetically compatible stem cells for bone marrow transplantation. A public UCB SCB has many facets to consider, one of which is public preparedness and support for the bank. This was assessed in a social feasibility pilot study which is reported here. In addition to the findings of this social feasibility study, other important considerations for establishing a public human UCB SCB in SA include; (a) testing the samples for HIV and other infectious diseases (required for compliance with international regulatory standards); (b) flow cytometric analysis for enumeration of CD34+ UCB stem cells; (c) mapping of HLA genotypes/alleles; and (d) a study of the economic feasibility of this endeavour.The social feasibility study was conducted to gauge public preparedness and support for a public SCB through patient interviews and questionnaires. The process was dynamic due to its novel nature for interviewers and interviewees alike. Many obstacles were met and dealt with which lead to the compilation of results discussed here in the form of a pilot social feasibility study.In the South African context, we are faced with unique and rich challenges relating to cultural and religious differences that are further augmented by

  20. LDL particle heterogeneity, and its association with other established cardiovascular risk factors in a young Indian industrial population

    PubMed Central

    Lakshmy, Ramakrishnan; Dorairaj, Prabhakaran; Tarik, Mohamad; Gupta, Ruby; Reddy, Kolli Srinath

    2012-01-01

    Objective Low density lipoprotein (LDL) particles are heterogeneous in terms of size, density, chemical composition and electric charge with certain particle of LDL being more atherogenic than the others. The present study aimed to look at the LDL particle heterogeneity, particle size and association with other cardiovascular disease (CVD) risk factors in young Indian industrial population. Methodology 600 employees of an industry of Delhi, aged 20-39 years were selected for the study. Data on demographics, individual characteristics associated with major risk factors of CVD, past medical history, clinical and anthropometric profile was collected. Fasting glucose, lipid profile, apolipoprotein (A1, B, and E), lipoprotein (a), high sensitive C-reactive protein (hsCRP) and insulin were estimated. LDL particle size was determined in ethylenediamminetetraacetate (EDTA) plasma by 3% polyacrylamide gel electrophoresis. Result We found a prevalence of small dense LDL phenotype (LDL size ≤ 26.3) in 27.4% of males and 24.0% of females. The mean waist circumference, blood pressure, triglycerides (TAG), cholesterol, hsCRP, apolipoprotein (A1, B and E) and insulin were higher in males whereas mean high density lipoprotein was higher in females. Females also had a significantly higher mean LDL particle diameter as compared to males. Conclusion TAG, physical activity and lipoprotein (a) correlated with small dense LDL in this young Indian population. PMID:27326051

  1. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2001-09-12

    The Pennsylvania State University, under contract to the US Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. the consortium creates a partnership with the US petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the third quarterly technical progress report for the SWC. During this reporting period the SWC entered into a co-funding arrangement with the New York State Energy Development Authority (NYSERDA) to provide an additional $100,000 in co-funding for stripper well production-orientated projects.The SWC hosted its first meeting in which members proposed research projects to the SWC membership. The meeting was held on April 9-10, 2001 in State College, Pennsylvania. Twenty three proposals were submitted to the SWC for funding consideration. Investigators of the proposed projects provided the SWC membership with a 20 minute (15 minute technical discussion, 5 minute question and answer session) presentation. Of the 23 proposals, the Executive Council approved $921,000 in funding for 13 projects. Penn State then immediately started the process of issuing subcontracts to the various projects approved for funding.

  2. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-05-10

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the eleventh quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) organizing and hosting the Spring SWC meeting in Pearl River, New York, (2) working with successful applicants and Penn State's Office of Sponsored Research to get subcontracts in place, and (3) planning three SWC technology transfer meetings to take place in the fall of 2003. During this reporting period, the efforts were focused primarily on the organizing and hosting the SWC Spring proposal meeting and organizing the fall technology transfer meetings.

  3. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2004-05-17

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the thirteenth quarterly technical progress report for the SWC. Key activities for this reporting period included: (1) hosting three fall technology transfer meetings in Wyoming, Texas, and Pennsylvania, (2) releasing the 2004 SWC request-for-proposal (RFP), and (3) initial planning of the SWC spring meeting in Golden Colorado for selecting the 2004 SWC projects. The Fall technology transfer meetings attracted 100+ attendees between the three workshops. The SWC membership which attended the Casper, Wyoming workshop was able to see several SWC-funded projects operating in the field at the Rocky Mountain Oilfield Testing Center. The SWC is nearing the end of its initial funding cycle. The Consortium has a solid membership foundation and a demonstrated ability to review and select projects that have relevancy to meet the needs of domestic stripper well operators.

  4. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel L. Morrison

    2005-08-30

    The Pennsylvania State University, under contract to the U.S. Department of Energy, National Energy Technology Laboratory will establish, promote, and manage a national industry-driven Stripper Well Consortium (SWC) that will be focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the nineteenth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) deliver a keynote luncheon address to the 16th Annual Oil Recovery Conference in Wichita, Kansas, (2) participated in the Interstate Oil & Gas Compact Commission's (IOGCC) Midyear Issues Summit in Anchorage, Alaska, (3) completed and distributed the SWC technical bulletin ''Keeping the Home Wells Flowing: Helping Small Independent Oil and Gas Producers Develop New Technology Solutions'', and (4) completed the primary filming of the Public Broadcast of ''Independent Oil: Rediscovering America's Forgotten Wells''.

  5. ESTABLISHMENT OF AN INDUSTRY-DRIVEN CONSORTIUM FOCUSED ON IMPROVING THE PRODUCTION PERFORMANCE OF DOMESTIC STRIPPER WELLS

    SciTech Connect

    Joel L. Morrison

    2002-09-30

    The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL), has established a national industry-driven Stripper Well Consortium (SWC) that is focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas industries and trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the second topical report. The SWC has grown and diversified its membership during its first 24 months of existence. The Consortium is now focused on building strategic alliances with additional industrial, state, and federal entities to expand further the SWC membership base and transfer technologies as they are developed. In addition, the Consortium has successfully worked to attract state support to co-fund SWC projects. Penn State has entered a co-funding arrangement with the New York State Energy Development Authority (NYSERDA) which has provided $200,000 over the last two years to co-fund stripper well production-orientated projects that have relevance to New York state producers. During this reporting period, the Executive Council approved co-funding for 14 projects that have a total project value of $2,116,897. Since its inception, the SWC has approved cofunding for 27 projects that have a total project value of $3,632,109.84. The SWC has provided $2,242,701 in co-funding for these projects and programmatically maintains a cost share of 39%.

  6. Establishment of a reference value for chromium in the blood for biological monitoring among occupational chromium workers.

    PubMed

    Li, Ping; Li, Yang; Zhang, Ji; Yu, Shan-Fa; Wang, Zhi-Liang; Jia, Guang

    2016-10-01

    The concentration of chromium in the blood (CrB) has been confirmed as a biomarker for occupational chromium exposure, but its biological exposure indices (BEIs) are still unclear, so we collected data from the years 2006 and 2008 (Shandong Province, China) to analyze the relationship between the concentration of chromium in the air (CrA) of the workplaces and CrB to establish a reference value of CrB for biological monitoring of occupational workers. The levels of the indicators for nasal injury, kidney (β2 microglobulin (β2-MG)), and genetic damages (8-hydroxy-deoxyguanosine (8-OHdG) and micronucleus (MN)) were measured in all subjects of the year 2011 (Henan Province, China) to verify the protective effect in this reference value of CrB. Compared with the control groups, the concentrations of CrA and CrB in chromium exposed groups were significantly higher (P < 0.05). Positive correlations were found between CrA and CrB in chromium exposed groups (r 2006 = 0.60, r 2008 = 0.35) in the years 2006 and 2008. According to the occupational exposure limitation of CrA (50 μg/m(3), China), the reference value of CrB was recommended to 20 μg/L. The levels of nasal injury, β2-MG, 8-OhdG, and MN were not significantly different between the low chromium exposed group (CrB ≤ 20 μg/L) and the control group, while the levels of β2-MG, 8-OHdG, and MN were statistically different in the high chromium exposed group than that in the control group. This research proved that only in occupational workers, CrB could be used as a biomarker to show chromium exposure in the environment. The recommended reference value of CrB was 20 μg/L.

  7. Establishment of an Industry-Driven Consortium Focused on Improving the Production Performance of Domestic Stripper Wells

    SciTech Connect

    Joel L. Morrison; Sharon L. Elder

    2006-06-30

    The Pennsylvania State University, under contract to the U.S. Department of Energy (DOE), National Energy Technology Laboratory (NETL) established a national industry-driven Stripper Well Consortium (SWC) that is focused on improving the production performance of domestic petroleum and/or natural gas stripper wells. The consortium creates a partnership with the U.S. petroleum and natural gas producers, trade associations, state funding agencies, academia, and the National Energy Technology Laboratory. This report serves as the ninth quarterly technical progress report for the SWC. Key activities for this reporting period include: (1) Develop and process subcontract awards for the nine projects selected at the 2006 Spring meeting; (2) Continue distribution of the DVD on ''Independent Oil: Rediscovering American's Forgotten Wells''; (3) Improving communications; (4) New member recruitment; (5) Identify SWC projects to be showcased for booth exhibition, preparing an exhibit, promoting and marketing for the 2006 Oklahoma Oil and Gas Trade Expo organized by the OK Marginal Well Commission, Oklahoma City, OK; and (6) Identify projects and draft agenda for the fall technical workshop in Pittsburgh, PA.

  8. Distribution of blood derivatives by registered blood establishments that qualify as health care entities; Prescription Drug Marketing Act of 1987; Prescription Drug Amendments of 1992; delay of applicability date. Final rule; delay of applicability date.

    PubMed

    2006-11-13

    The Food and Drug Administration (FDA) is further delaying, until December 1, 2008, the applicability date of a certain requirement of a final rule published in the Federal Register of December 3, 1999 (64 FR 67720) (the final rule). The final rule implements the Prescription Drug Marketing Act of 1987 (PDMA), as modified by the Prescription Drug Amendments of 1992 (PDA), and the Food and Drug Administration Modernization Act of 1997 (the Modernization Act). The provisions of the final rule became effective on December 4, 2000, except for certain provisions whose effective or applicability dates were delayed in five subsequent Federal Register notices, until December 1, 2006. The provision with the delayed applicability date would prohibit wholesale distribution of blood derivatives by registered blood establishments that meet the definition of a "health care entity." In the Federal Register of February 1, 2006 (71 FR 5200), FDA published a proposed rule specific to the distribution of blood derivatives by registered blood establishments that qualify as health care entities (the proposed rule). The proposed rule would amend certain limited provisions of the final rule to allow certain registered blood establishments that qualify as health care entities to distribute blood derivatives. In response to the proposed rule, FDA received substantive comments. As explained in the SUPPLEMENTARY INFORMATION section of this document, further delaying the applicability of Sec. 203.3(q) (21 CFR 203.3(q)) to the wholesale distribution of blood derivatives by health care entities is necessary to give the agency additional time to address comments on the proposed rule, consider whether regulatory changes are appropriate, and, if so, to initiate such changes.

  9. [Establishment of a method for HLA-DRB genotyping in cord blood by reverse dot-blot hybridization technique].

    PubMed

    Huang, Yi-Ning; Liao, Can; Tang, Xue-Wei; Li, Yan; Xie, Xing-Mei; Zeng, Rui-Ping

    2002-04-01

    The HLA system was discovered by virtue of the fact that it was polymorphic. The impetus for its discovery was the search for polymorphic antigens to match for transplantation, by analogy with the human red cell blood groups. The most usually DNA method of HLA typing is sequence specific oligonucleotides (SSO) and PCR sequence specific primers (SSP). SSO technique is perfectly suited for analyzing large number of samples, it is not suitable for individual or small numbers. The SSP method is ideal for typing individual samples, but it is costly and requires high capacity thermal cycles for larger numbers of samples. To set up a simple, quick, cheap and high resolution DNA method, were collected sixty-three cord blood samples from Guangzhou Cord Blood Bank, got DNA from blood by the traditional guanidine hydrochloride distillation method. Each sample was simultaneously typed by SSOP, PCR-SSP and reverse dot-blot hybridization (RDB) methods. All of typed is success. The results of three DNA methods are consistent each other. 60 HLA-DRB1 alleles could be accurately distinguished with the RDB method. Our results show that RDB method is a simple, quick, cheap and high resolution method for HLA-DRB types. It can be used in any HLA typing.

  10. The effects of occupational noise on blood pressure and heart rate of workers in an automotive parts industry

    PubMed Central

    Kalantary, Saba; Dehghani, Ali; Yekaninejad, Mir Saeed; Omidi, Leila; Rahimzadeh, Mitra

    2015-01-01

    BACKGROUND One of the most important impacts of industrial noise is physiological and psychological effects. The increases in workers’ blood pressure and heart rate were detected during and after exposure to high levels of noise. The objectives of this research were to determine whether the noise exposures have any effects on blood pressure and heart rate of workers in the automotive parts industry. METHODS This case study was done in 2011 at different units of an automotive parts manufacturing in Tehran. Sound pressure level was measured at different units of the factory with a calibrated instrument. Demographic features of workers were gathered with an appropriate questionnaire. Heart rate and blood pressure were measured twice in a day in the start time of work day (before exposure to noise) and middle shift hours (during exposure to noise) in the occupational physician office. For analyzing data, chi-square, independent sample t-test, paired t-test, and analysis of covariance (ANCOVA) were used. P < 0.050 was considered statistically significant. RESULTS The average age of workers in the case and control groups was 35.71 ± 8.10 and 33.40 ± 10.41 years, respectively. There was no difference between the average age of case and control groups (P = 0.436). The results of ANCOVA revealed the significant differences between the mean changes of heart rate F (1, 37) = 26.68, P < 0.001, systolic blood pressure F (1, 37) = 21.70, P < 0.001, and diastolic blood pressure F (1, 37) = 26.20, P < 0.001 of workers in the case and control groups. CONCLUSION Exposure to industrial noise may increase the heart rate of workers. Although rises in heart rate, systolic, and diastolic blood pressure of workers in the case group were observed after exposure to noise, the values of heart rate, systolic, and diastolic blood pressure were in the normal range. Further experimental investigations are needed to determine the relationships between these variables. PMID:26478728

  11. Establishing baseline levels of trace elements in blood and skin of bottlenose dolphins in Sarasota Bay, Florida: implications for non-invasive monitoring.

    PubMed

    Bryan, Colleen E; Christopher, Steven J; Balmer, Brian C; Wells, Randall S

    2007-12-15

    Several major unusual mortality events occurring in recent years have increased the level of concern for the health of bottlenose dolphin populations along the United States Atlantic and Gulf of Mexico coasts. Trace element concentrations were examined in a population of free-ranging dolphins in Sarasota Bay, Florida, in order to develop a benchmark for future comparisons within and between populations. Whole blood (n=51) and skin (n=40) samples were collected through capture and release health assessment events during 2002-2004. Samples were analyzed for Al, V, Cr, Mn, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, and Pb by inductively coupled plasma mass spectrometry (ICPMS) and Hg via atomic fluorescence spectrometry (AFS). Trace element concentrations (wet mass) in skin were 2 to 45 times greater than blood, except Cu was approximately 1.5 times higher in blood. Statistically strong correlations (p<0.05) were found for V, As, Se, Rb, Sr, and Hg between blood and skin demonstrating that these tissues can be used as effective non-lethal monitoring tools. The strongest correlation was established for Hg (r=0.9689) and concentrations in both blood and skin were above the threshold at which detrimental effects are observed in other vertebrate species. Female dolphins had significantly greater Hg concentrations in blood and skin and Pb concentrations in skin, relative to males. Calves exhibited significantly lower V, As, and Hg concentrations in blood and V and Hg concentrations in skin, relative to other age classes. Rubidium and Cu concentrations in skin were greatest in subadults and calves, respectively. In blood, V, Zn, and As concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Rb and Sr concentrations. In skin, Cu and Zn concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Mn, Rb, Cd, and Pb concentrations. The baseline concentrations and trends

  12. [Influence of chronic irradiation on the distribution of blood lymphocyte subpopulations among professionals of the atomic industry].

    PubMed

    Selivanova, E I; Zamulaeva, I A; Saenko, A S

    2014-01-01

    The aim of the study was to investigate the effects of chronic exposure to ionizing radiation on the cellular immunity of employees of the nuclear industry. Peripheral blood samples were studied in 195 employees of Physics and Power Engineering Institute (PPEI, Obninsk), who professionallycontacted with sources ofionizing radiation and were under individual dosimetric control. The median cumulative dose was 61.2 mSv, the average duration of work at the enterprise -27 ± 5 years. The control group consisted of 57 healthy individuals of a similar age and sex who did not have contact with sources of radiation. Indicators of the cellular immunity were determined by flow cytometry. Comparison of a cell-mediated immunity was conducted separately in the two age groups (20-40 and 41-70 years). The significant reduction inthe relative content of CD4+CD8 T-helper cells and the increase in the relative content of CD3-CD16, CD56+ NK-cells were found in both age groups of the PPEI employees in comparison with the age-matched control groups (p < 0.05). Separate analysis of the results in the low dose group (up to 50 mSv) demonstrated reducing the relative content of T-helper cells and increasing the proportion of NK-cells (as in the analysis of whole groups without taking into account the cumulative dose), as well as reducing the proportion of CD8+CD25+ activated lymphocytes in PPEI employees as compared to the age-matched control. Multiple regression analysis of the immunological parameters dependence on age and dose established a significant correlation of the relative content of CD3-CD19+ B-cells (r = -0.284, p = 2.9 x 10(-4)) and CD19+CD5+ B1-lymphocytes (r = -0.241, p = 0.002) with the dose of employees regardless of age, indicating the relationship of the changes in the B-cell component of immune system with the radiation factor. PMID:25764816

  13. VPX mutants of HIV-2 are infectious in established cell lines but display a severe defect in peripheral blood lymphocytes.

    PubMed Central

    Guyader, M; Emerman, M; Montagnier, L; Peden, K

    1989-01-01

    Nucleotide sequence comparison between HIV-1, HIV-2 and SIV has revealed the presence of an open reading frame (ORF) in the central region of the genomes of HIV-2 and SIV that has no counterpart in HIV-1. This new ORF, called vpx, is highly conserved between HIV-2ROD and SIVmac. Using anti-peptide sera to the predicted protein and site-directed mutagenesis, we show that mutations in the vpx ORF eliminate the synthesis of a 16 kd protein in HIV-2 infected cells, confirming that this protein is the product of this gene. Full-length clones of HIV-2 containing these mutations are infectious in two permanent T lymphocytic cell lines and two monocytic cell lines. In contrast, we show that loss of VPX function results in a severe defect in the productive infection of human peripheral blood lymphocytes both in the amount of reverse transcriptase activity produced and in core protein expression. These findings suggest that the VPX protein plays an important role in the in vivo life cycle of the HIV-2/SIV viruses. Images PMID:2743977

  14. Needlestick injury in clothing industry workers and the risks of blood-borne infection.

    PubMed

    Ind, J E; Jeffries, D J

    1999-01-01

    This paper identifies the hazard of a hollow needle device used extensively in the clothing industry and assesses the risk of transmission for HIV, Hepatitis B and Hepatitis C. A substantial risk of transmission is suggested and measures have been advised for its control. Occupational Health Physicians are advised to be aware of hollow needles in other industrial processes and where risks of cross-infection exist, the same safety considerations should be applied as in clinical medicine and veterinary work to avoid needlestick injuries. Needle sharing must be avoided.

  15. Industrially scaled pulsed laser deposition based coating techniques for the realization of hemocompatible surfaces for blood contact applications

    NASA Astrophysics Data System (ADS)

    Lackner, Juergen M.; Waldhauser, Wolfgang; Major, Roman; Major, Boguslaw; Czarnowska, Elzbieta; Bruckert, Franz

    2008-05-01

    Non-thrombogenic blood contacting surfaces and appropriate blood flow characteristics are essential for clinical application. State-of-the-art coatings are based on heparin and struggle with the problem of bleeding. Thus, there is increasing demand for developing new coating materials for improved human body acceptance. Materials deposited by vacuum coating techniques would be an excellent alternative if the coating temperatures can be kept low due to the applied substrate materials of low temperature resistance (mostly polymers). Under these circumstances, adequate film structure and high adhesion can be reached by the Pulsed Laser Deposition at room temperature (RT-PLD), which was developed to an industrial-scaled process at Laser Center Leoben. This process was applied to deposit Ti, TiN, TiCN and diamond-like carbon (DLC) on polyurethane, titanium and silicon substrates to study the biological interactions to blood cells and the kinetic mechanism of eukaryote cell attachment. Besides high biological acceptance, distinct differences for the critical delamination shear stress were found for the coatings, indicating higher adhesion at higher carbon contents.

  16. 76 FR 22903 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing That a Tobacco...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ... Commercially Marketed in the United States as of February 15, 2007.'' It does not create or confer any rights... Staff; Establishing That a Tobacco Product Was Commercially Marketed in the United States as of February... Product Was Commercially Marketed in the United States as of February 15, 2007.'' This draft...

  17. Innovations in Apprenticeship: The Feasibility of Establishing Demonstration Centers for Apprenticeship and Other Industrial Training. Final Report.

    ERIC Educational Resources Information Center

    Somers, Gerald G.

    In order to determine the feasibility of establishing demonstration centers for apprenticeship and skill training, extensive interviews were conducted involving union officers, employer representatives, vocational educators, and officials of federal and state apprenticeship divisions in this country and abroad during the period from 1971 through…

  18. A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach.

    PubMed

    Chou, Bin-Kuan; Gu, Haihui; Gao, Yongxing; Dowey, Sarah N; Wang, Ying; Shi, Jun; Li, Yanxin; Ye, Zhaohui; Cheng, Tao; Cheng, Linzhao

    2015-04-01

    Reprogramming human adult blood mononuclear cells (MNCs) cells by transient plasmid expression is becoming increasingly popular as an attractive method for generating induced pluripotent stem (iPS) cells without the genomic alteration caused by genome-inserting vectors. However, its efficiency is relatively low with adult MNCs compared with cord blood MNCs and other fetal cells and is highly variable among different adult individuals. We report highly efficient iPS cell derivation under clinically compliant conditions via three major improvements. First, we revised a combination of three EBNA1/OriP episomal vectors expressing five transgenes, which increased reprogramming efficiency by ≥10-50-fold from our previous vectors. Second, human recombinant vitronectin proteins were used as cell culture substrates, alleviating the need for feeder cells or animal-sourced proteins. Finally, we eliminated the previously critical step of manually picking individual iPS cell clones by pooling newly emerged iPS cell colonies. Pooled cultures were then purified based on the presence of the TRA-1-60 pluripotency surface antigen, resulting in the ability to rapidly expand iPS cells for subsequent applications. These new improvements permit a consistent and reliable method to generate human iPS cells with minimal clonal variations from blood MNCs, including previously difficult samples such as those from patients with paroxysmal nocturnal hemoglobinuria. In addition, this method of efficiently generating iPS cells under feeder-free and xeno-free conditions allows for the establishment of clinically compliant iPS cell lines for future therapeutic applications.

  19. A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach.

    PubMed

    Chou, Bin-Kuan; Gu, Haihui; Gao, Yongxing; Dowey, Sarah N; Wang, Ying; Shi, Jun; Li, Yanxin; Ye, Zhaohui; Cheng, Tao; Cheng, Linzhao

    2015-04-01

    Reprogramming human adult blood mononuclear cells (MNCs) cells by transient plasmid expression is becoming increasingly popular as an attractive method for generating induced pluripotent stem (iPS) cells without the genomic alteration caused by genome-inserting vectors. However, its efficiency is relatively low with adult MNCs compared with cord blood MNCs and other fetal cells and is highly variable among different adult individuals. We report highly efficient iPS cell derivation under clinically compliant conditions via three major improvements. First, we revised a combination of three EBNA1/OriP episomal vectors expressing five transgenes, which increased reprogramming efficiency by ≥10-50-fold from our previous vectors. Second, human recombinant vitronectin proteins were used as cell culture substrates, alleviating the need for feeder cells or animal-sourced proteins. Finally, we eliminated the previously critical step of manually picking individual iPS cell clones by pooling newly emerged iPS cell colonies. Pooled cultures were then purified based on the presence of the TRA-1-60 pluripotency surface antigen, resulting in the ability to rapidly expand iPS cells for subsequent applications. These new improvements permit a consistent and reliable method to generate human iPS cells with minimal clonal variations from blood MNCs, including previously difficult samples such as those from patients with paroxysmal nocturnal hemoglobinuria. In addition, this method of efficiently generating iPS cells under feeder-free and xeno-free conditions allows for the establishment of clinically compliant iPS cell lines for future therapeutic applications. PMID:25742692

  20. Moving East: how the transnational tobacco industry gained entry to the emerging markets of the former Soviet Union—part I: establishing cigarette imports

    PubMed Central

    Gilmore, A; McKee, M

    2004-01-01

    Objectives: To identify British American Tobacco's (BAT) reasons for targeting the former Soviet Union following its collapse in 1991 and the initial strategies BAT used to enter the region. Design: Analysis of tobacco industry documents held at the Guildford BAT archive. Results: Desire to expand to new markets was based in part on the decline in old markets. The large population, proximity to China, scope to expand sales to women and, in Central Asia, a young population with high growth rates made the former Soviet Union particularly attractive. High consumption rates and unfilled demand caused by previous shortages offered potential for rapid returns on investment. A series of steps were taken to penetrate the markets with the initial focus on establishing imports. The documents suggest that BAT encouraged the use of aid money and barter trade to fund imports and directed the smuggling of cigarettes which graduated from an opportunistic strategy to a highly organised operation. In establishing a market presence, promotion of BAT's brands and corporate image were paramount, and used synonymously to promote both the cigarettes and the company. The tobacco industry targeted young people and women. It used the allure of western products to promote its brands and brand stretching and corporate imagery to pre-empt future marketing restrictions. Conclusions: BAT used the chaotic conditions in the immediate post-transition period in the former Soviet Union to exploit legislative loopholes and ensure illegal cigarette imports. Governments of countries targeted by the tobacco industry need to be aware of industry tactics and develop adequate tobacco control policies in order to prevent the exploitation of vulnerable populations. Marketing restrictions that focus on advertising without restricting the use of brand or company promotions will have a limited impact. PMID:15175531

  1. Industry

    SciTech Connect

    Bernstein, Lenny; Roy, Joyashree; Delhotal, K. Casey; Harnisch, Jochen; Matsuhashi, Ryuji; Price, Lynn; Tanaka, Kanako; Worrell, Ernst; Yamba, Francis; Fengqi, Zhou; de la Rue du Can, Stephane; Gielen, Dolf; Joosen, Suzanne; Konar, Manaswita; Matysek, Anna; Miner, Reid; Okazaki, Teruo; Sanders, Johan; Sheinbaum Parado, Claudia

    2007-12-01

    This chapter addresses past, ongoing, and short (to 2010) and medium-term (to 2030) future actions that can be taken to mitigate GHG emissions from the manufacturing and process industries. Globally, and in most countries, CO{sub 2} accounts for more than 90% of CO{sub 2}-eq GHG emissions from the industrial sector (Price et al., 2006; US EPA, 2006b). These CO{sub 2} emissions arise from three sources: (1) the use of fossil fuels for energy, either directly by industry for heat and power generation or indirectly in the generation of purchased electricity and steam; (2) non-energy uses of fossil fuels in chemical processing and metal smelting; and (3) non-fossil fuel sources, for example cement and lime manufacture. Industrial processes also emit other GHGs, e.g.: (1) Nitrous oxide (N{sub 2}O) is emitted as a byproduct of adipic acid, nitric acid and caprolactam production; (2) HFC-23 is emitted as a byproduct of HCFC-22 production, a refrigerant, and also used in fluoroplastics manufacture; (3) Perfluorocarbons (PFCs) are emitted as byproducts of aluminium smelting and in semiconductor manufacture; (4) Sulphur hexafluoride (SF{sub 6}) is emitted in the manufacture, use and, decommissioning of gas insulated electrical switchgear, during the production of flat screen panels and semiconductors, from magnesium die casting and other industrial applications; (5) Methane (CH{sub 4}) is emitted as a byproduct of some chemical processes; and (6) CH{sub 4} and N{sub 2}O can be emitted by food industry waste streams. Many GHG emission mitigation options have been developed for the industrial sector. They fall into three categories: operating procedures, sector-wide technologies and process-specific technologies. A sampling of these options is discussed in Sections 7.2-7.4. The short- and medium-term potential for and cost of all classes of options are discussed in Section 7.5, barriers to the application of these options are addressed in Section 7.6 and the implication of

  2. Relationships between blood lead concentration and aminolevulinic acid dehydratase in alcoholics and workers industrially exposed to lead

    SciTech Connect

    Bortoli, A.; Fazzin, G.; Marin, V.; Trabuio, G.; Zotti, S.

    1986-07-01

    Blood lead concentration (Pb-B), aminolevulinic acid dehydratase (ALAD), and gamma-GT were measured in 265 workers industrially exposed to lead and in 184 patients with liver disease resulting from alcohol consumption. The first group was divided according to alcohol use, i.e., nondrinkers, moderate drinkers, and heavy drinkers. The second group was divided according to the following criteria: hepatopatic without cirrhosis, hepatopatic with compensated cirrhosis, and hepatopatic with decompensated cirrhosis. Heavy drinkers who were industrially exposed had the highest Pb-B (40.4 +/- 14.6 micrograms/dl) and the lowest ALAD (22.2 +/- 9.1 U/L). The correlations between Pb-B and ALAD show no significant change with the increase of Pb-B. In the alcoholic group, 76 patients with alcoholic liver disease without cirrhosis had the highest Pb-B (40.3-9.1 micrograms/dl) and ALAD the lowest (18.6 +/- 7.7 U/L). The negative correlation between Pb-B and log ALAD disappeared completely in individuals with Pb-B that exceeded 50 micrograms/dl, independent from the seriousness of illness.

  3. 78 FR 38994 - Implanted Blood Access Devices for Hemodialysis; Draft Guidance for Industry and Food and Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... HUMAN SERVICES Food and Drug Administration Implanted Blood Access Devices for Hemodialysis; Draft... availability of the draft guidance entitled ``Implanted Blood Access Devices for Hemodialysis.'' This guidance was developed to support the reclassification of the Implanted Blood Access Devices for...

  4. Establishment of the biochemical and endocrine blood profiles in the Majorera and Palmera dairy goat breeds: the effect of feed restriction.

    PubMed

    Lérias, Joana R; Peña, Raquel; Hernández-Castellano, Lorenzo E; Capote, Juan; Castro, Noemí; Argüello, Anastasio; Araújo, Susana S; Saco, Yolanda; Bassols, Anna; Almeida, André M

    2015-11-01

    Feed restriction, and seasonal weight loss (SWL), are major setbacks for animal production in the tropics and the Mediterranean. They may be solved through the use of autochthonous breeds particularly well adapted to SWL. It is therefore of major importance to determine markers of tolerance to feed restriction of putative use in animal selection. Two indigenous breeds from the Canary Islands, Palmera and Majorera, are commonly used by dairy goat farmers and, interestingly, have different phenotype characteristics albeit with a common ancestry. Indeed, Majorera is well adapted to feed restriction whereas the Palmera is susceptible to feed restriction. In addition, regardless of their importance in dairy production, there are only a limited number of reports relating to these breeds and, to the best of our knowledge, there is no description of their blood metabolite standard values under control conditions or as affected by feed restriction. In this study we analysed the blood metabolite profiles in Majorera and Palmera goats aiming to establish the differential responses to feed restriction between the two breeds and to characterise their metabolite standard values under control conditions. We observed significant differences in creatinine, urea, non-esterified fatty acids (NEFAs), cholesterol, IGF-1 and T3 due to underfeeding. Furthermore, a PCA analysis, revealed that animals submitted to undernutrition could be distinguished from the control groups, with the formation of three separate clusters (Palmera individuals after 22 d of subnutrition (PE22); Majorera individuals after 22 d of subnutrition (ME22) and animals assigned to control conditions (MC0, MC22, PC0 and PC22)), highlighting different responses of the two breeds to undernutrition. PMID:26290160

  5. Establishment of the biochemical and endocrine blood profiles in the Majorera and Palmera dairy goat breeds: the effect of feed restriction.

    PubMed

    Lérias, Joana R; Peña, Raquel; Hernández-Castellano, Lorenzo E; Capote, Juan; Castro, Noemí; Argüello, Anastasio; Araújo, Susana S; Saco, Yolanda; Bassols, Anna; Almeida, André M

    2015-11-01

    Feed restriction, and seasonal weight loss (SWL), are major setbacks for animal production in the tropics and the Mediterranean. They may be solved through the use of autochthonous breeds particularly well adapted to SWL. It is therefore of major importance to determine markers of tolerance to feed restriction of putative use in animal selection. Two indigenous breeds from the Canary Islands, Palmera and Majorera, are commonly used by dairy goat farmers and, interestingly, have different phenotype characteristics albeit with a common ancestry. Indeed, Majorera is well adapted to feed restriction whereas the Palmera is susceptible to feed restriction. In addition, regardless of their importance in dairy production, there are only a limited number of reports relating to these breeds and, to the best of our knowledge, there is no description of their blood metabolite standard values under control conditions or as affected by feed restriction. In this study we analysed the blood metabolite profiles in Majorera and Palmera goats aiming to establish the differential responses to feed restriction between the two breeds and to characterise their metabolite standard values under control conditions. We observed significant differences in creatinine, urea, non-esterified fatty acids (NEFAs), cholesterol, IGF-1 and T3 due to underfeeding. Furthermore, a PCA analysis, revealed that animals submitted to undernutrition could be distinguished from the control groups, with the formation of three separate clusters (Palmera individuals after 22 d of subnutrition (PE22); Majorera individuals after 22 d of subnutrition (ME22) and animals assigned to control conditions (MC0, MC22, PC0 and PC22)), highlighting different responses of the two breeds to undernutrition.

  6. Establishment of a mammalian cell line suitable for industrial production of recombinant protein using mutations induced by high-energy beam radiation.

    PubMed

    Chida, Yasuhito; Takagi, Keiichi; Terada, Satoshi

    2013-12-01

    Mammalian cells are extensively used for production of biopharmaceuticals. Most cells used in industry have infinite proliferative capacity, which provides a high number of cells and corresponding productivity. However, infinite cells will continue to multiply even after cell density reaches sufficient levels. This excess proliferation aggravates the culture environment and induces low productivity. Therefore, after cell density reaches sufficient levels, downregulation of proliferation would prevent such aggravation and extend the culture period and improve productivity. To realize such suitable proliferation, we aimed to establish a novel cell line whose proliferation was spontaneously downregulated after reaching a sufficient population level. Mutagenesis using high-energy beam irradiation was used. CHO-DP12 cells were irradiated with 2.5 Gy X-rays and screened with hydroxyurea and 5-fluorouracil to eliminate any cells multiplying after confluence and to concentrate desired mutants. One clone was established and named CHO-M1. Cell cycle analysis indicated that CHO-M1 cells had a similar cell cycle profile in the exponential growth phase, but cells rapidly accumulated in G1 phase just before confluence and did not progress through the cell cycle. This suggested that until confluence, proliferation of CHO-M1 was similar to parental CHO, but after confluence, it was inhibited and under G1 arrest. The specific antibody production rate of CHO-M1 was kept high, even after confluence, while that of parental CHO was drastically decreased in stationary phase. These results suggest that the desired cell line was successfully established and that high-energy beam irradiation could be an efficient mutagenic technique for breeding industrial cells.

  7. Establishment of an adherent cell feeder layer from human umbilical cord blood for support of long-term hematopoietic progenitor cell growth.

    PubMed Central

    Ye, Z Q; Burkholder, J K; Qiu, P; Schultz, J C; Shahidi, N T; Yang, N S

    1994-01-01

    Previous attempts to establish a stromal cell feeder layer from human umbilical cord blood (HUCB) have met with very limited success. It has been suggested that there is an insufficient number of stromal precursor cells in HUCB to form a hematopoietic-supporting feeder layer in primary cultures. The present study shows that HUCB does contain a significant accessory cell population that routinely develops into a confluent, adherent cell layer under defined primary culture conditions. HUCB-derived adherent layers were shown to support long-term hematopoietic activity for an average of 4 months. This was achieved by using a customized coverslip with a modified surface structure as the cell attachment substratum and using a specialized culture feeding regime. We have characterized the various cell types (including fibroblasts, macrophages, and endothelial cells) and extracellular matrix proteins (including fibronectin, collagen III, and laminin) that were present in abundance in the HUCB-derived adherent cell layer. In contrast, oil red O-staining fat cells were rarely detected. ELISA and bioassays showed that stem cell factor and interleukin 6 were produced by the HUCB stromal cell cultures, but interleukin 3 or granulocyte/macrophage colony-stimulating factor was not detected. Application of this hematopoietic culture system to transgenic and gene therapy studies of stem cells is discussed. Images PMID:7527553

  8. Predicting the hazardous dose of industrial chemicals in warm-blooded species using machine learning-based modelling approaches.

    PubMed

    Gupta, S; Basant, N; Singh, K P

    2015-06-01

    The hazardous dose of a chemical (HD50) is an emerging and acceptable test statistic for the safety/risk assessment of chemicals. Since it is derived using the experimental toxicity values of the chemical in several test species, it is highly cumbersome, time and resource intensive. In this study, three machine learning-based QSARs were established for predicting the HD50 of chemicals in warm-blooded species following the OECD guidelines. A data set comprising HD50 values of 957 chemicals was used to develop SDT, DTF and DTB QSAR models. The diversity in chemical structures and nonlinearity in the data were verified. Several validation coefficients were derived to test the predictive and generalization abilities of the constructed QSARs. The chi-path descriptors were identified as the most influential in three QSARs. The DTF and DTB performed relatively better than SDT model and yielded r(2) values of 0.928 and 0.959 between the measured and predicted HD50 values in the complete data set. Substructure alerts responsible for the toxicity of the chemicals were identified. The results suggest the appropriateness of the developed QSARs for reliably predicting the HD50 values of chemicals, and they can be used for screening of new chemicals for their safety/risk assessment for regulatory purposes.

  9. A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug.

    PubMed

    Freese, Christian; Reinhardt, Sven; Hefner, Gudrun; Unger, Ronald E; Kirkpatrick, C James; Endres, Kristina

    2014-01-01

    In the pathogenesis of Alzheimer's disease (AD) the homeostasis of amyloid precursor protein (APP) processing in the brain is impaired. The expression of the competing proteases ADAM10 (a disintegrin and metalloproteinase 10) and BACE-1 (beta site APP cleaving enzyme 1) is shifted in favor of the A-beta generating enzyme BACE-1. Acitretin--a synthetic retinoid-e.g., has been shown to increase ADAM10 gene expression, resulting in a decreased level of A-beta peptides within the brain of AD model mice and thus is of possible value for AD therapy. A striking challenge in evaluating novel therapeutically applicable drugs is the analysis of their potential to overcome the blood-brain barrier (BBB) for central nervous system targeting. In this study, we established a novel cell-based bio-assay model to test ADAM10-inducing drugs for their ability to cross the BBB. We therefore used primary porcine brain endothelial cells (PBECs) and human neuroblastoma cells (SH-SY5Y) transfected with an ADAM10-promoter luciferase reporter vector in an indirect co-culture system. Acitretin served as a model substance that crosses the BBB and induces ADAM10 expression. We ensured that ADAM10-dependent constitutive APP metabolism in the neuronal cells was unaffected under co-cultivation conditions. Barrier properties established by PBECs were augmented by co-cultivation with SH-SY5Y cells and they remained stable during the treatment with acitretin as demonstrated by electrical resistance measurement and permeability-coefficient determination. As a consequence of transcellular acitretin transport measured by HPLC, the activity of the ADAM10-promoter reporter gene was significantly increased in co-cultured neuronal cells as compared to vehicle-treated controls. In the present study, we provide a new bio-assay system relevant for the study of drug targeting of AD. This bio-assay can easily be adapted to analyze other Alzheimer- or CNS disease-relevant targets in neuronal cells, as their

  10. A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug.

    PubMed

    Freese, Christian; Reinhardt, Sven; Hefner, Gudrun; Unger, Ronald E; Kirkpatrick, C James; Endres, Kristina

    2014-01-01

    In the pathogenesis of Alzheimer's disease (AD) the homeostasis of amyloid precursor protein (APP) processing in the brain is impaired. The expression of the competing proteases ADAM10 (a disintegrin and metalloproteinase 10) and BACE-1 (beta site APP cleaving enzyme 1) is shifted in favor of the A-beta generating enzyme BACE-1. Acitretin--a synthetic retinoid-e.g., has been shown to increase ADAM10 gene expression, resulting in a decreased level of A-beta peptides within the brain of AD model mice and thus is of possible value for AD therapy. A striking challenge in evaluating novel therapeutically applicable drugs is the analysis of their potential to overcome the blood-brain barrier (BBB) for central nervous system targeting. In this study, we established a novel cell-based bio-assay model to test ADAM10-inducing drugs for their ability to cross the BBB. We therefore used primary porcine brain endothelial cells (PBECs) and human neuroblastoma cells (SH-SY5Y) transfected with an ADAM10-promoter luciferase reporter vector in an indirect co-culture system. Acitretin served as a model substance that crosses the BBB and induces ADAM10 expression. We ensured that ADAM10-dependent constitutive APP metabolism in the neuronal cells was unaffected under co-cultivation conditions. Barrier properties established by PBECs were augmented by co-cultivation with SH-SY5Y cells and they remained stable during the treatment with acitretin as demonstrated by electrical resistance measurement and permeability-coefficient determination. As a consequence of transcellular acitretin transport measured by HPLC, the activity of the ADAM10-promoter reporter gene was significantly increased in co-cultured neuronal cells as compared to vehicle-treated controls. In the present study, we provide a new bio-assay system relevant for the study of drug targeting of AD. This bio-assay can easily be adapted to analyze other Alzheimer- or CNS disease-relevant targets in neuronal cells, as their

  11. GUIDELINES FOR HOSPITALITY EDUCATION IN JUNIOR COLLEGES, A MANUAL FOR THE ESTABLISHMENT OF PROGRAMS FOR CAREERS IN THE HOTEL-MOTEL, RESTAURANT, AND INSTITUTIONAL INDUSTRIES.

    ERIC Educational Resources Information Center

    ALMARODE, RICHARD L.

    THIS REPORT DISCUSSES JUNIOR COLLEGE PROGRAMS TO MEET THE NEEDS OF STUDENTS AND INDUSTRY. THE STUDENTS RECEIVE BOTH EDUCATION AND TRAINING, WHILE INDUSTRY RECEIVES COMPETENT EMPLOYEES. BEFORE DEVELOPING THIS OCCUPATIONAL PROGRAM, THE COLLEGE SHOULD SURVEY LOCAL INDUSTRY NEEDS, OPPORTUNITIES FOR ON-THE-JOB TRAINING, POSSIBILITIES OF PART-TIME WORK…

  12. Industry Employment

    ERIC Educational Resources Information Center

    Occupational Outlook Quarterly, 2012

    2012-01-01

    This article illustrates projected employment change by industry and industry sector over 2010-20 decade. Workers are grouped into an industry according to the type of good produced or service provided by the establishment for which they work. Industry employment projections are shown in terms of numeric change (growth or decline in the total…

  13. Autologous blood donor screening indicated a lower prevalence of viral hepatitis in East vs West Germany: epidemiological benefit from established health resources.

    PubMed

    Wiegand, J; Luz, B; Mengelkamp, A-K; Moog, R; Koscielny, J; Halm-Heinrich, I; Susemihl, C; Bentzien, F; Diekmann, J; Wernet, D; Karger, R; Angert, K; Schmitt-Thomssen, A; Kiefel, V; Lutter, K; Hesse, R; Kätzel, R; Opitz, A; Luhm, J; Barz, D; Leib, U; Matthes, G; Tillmann, H L

    2009-10-01

    Prevalence data concerning viral hepatitis and human immunodeficiency virus (HIV) in the general population are usually scarce. We aimed for a large cohort representative of the general population that required little funding. Autologous blood donors are relatively representative of the general population, and are tested for viral hepatitis and HIV in many countries. However, frequently these data are not captured for epidemiologic purposes. We analysed data from well over 35,000 autologous blood donors as recorded in 21 different transfusion centres for anti-hepatitis C virus (HCV), HBsAg and anti-HIV, as well as TPHA if available. We found a lower prevalence of hepatitis B virus and HCV in East vs West Germany, 0.2%vs 0.32% and 0.16%vs 0.32% respectively, which confirms earlier data in smaller cohorts, thus supporting the value of our approach. HIV was too rare to disclose significant differences, 0.01%vs 0.02%. TPHA was higher in East (0.34%) vs West Germany (0.29%) without significant differences. HCV was more frequent in women vs men. Transfusion institutes managing autologous blood donations should be used as a resource for epidemiological data relating to viral hepatitis and HIV, if such testing is performed routinely. This approach generates data relating to the general population with special emphasis on undiagnosed cases.

  14. A Study of the Aquaculture Industry in Texas to Assist in Establishing Aquaculture as a Course Offering in Agricultural Science and Technology. Final Report.

    ERIC Educational Resources Information Center

    Dillingham, John; And Others

    A 1989-90 project determined the knowledge and skills necessary for employment in the aquaculture industry. The study identified technical materials and other resources available in private industry and higher education institutions. Two surveys determined the status of aquaculture in Texas school districts and identified tasks performed by…

  15. A comprehensive experimental study of industrial, domestic and environmental interferences with the forensic luminol test for blood.

    PubMed

    Creamer, J I; Quickenden, T I; Apanah, M V; Kerr, K A; Robertson, P

    2003-01-01

    This paper presents the fi rst comprehensive and quantitative study of substances that interfere with the forensic luminol test for blood. Two hundred and fifty substances have been selected on the basis of modern lifestyles and of contiguity with crime scenes. The intensity of the chemiluminescence produced by each substance has been measured relative to that of haemoglobin and the peak wavelength shift has also been determined. The following is a short list of nine substances that produce chemiluminescence intensities comparable with that of haemoglobin: turnips, parsnips, horseradishes, commercial bleach (NaClO), copper metal, some furniture polishes, some enamel paints, and some interior fabrics in motor vehicles. Care needs to be taken when the luminol test for blood is used in the presence of these substances.

  16. The Establishment of a National Industrial Wastes Inventory. Hearing Before a Subcommittee of the Committee on Government Operations, H.R. 91st Congress, September 17, 1970.

    ERIC Educational Resources Information Center

    Congress of the U. S., Washington, DC. House Committee on Government Operations.

    Presented in this bulletin is the test of the hearing before the Conservation and Natural Resources Subcommittee of the Committee on Government Operations, United States House of Representatives, ninety-first Congress, concerning a national inventory of industrial wastes. The hearing was held September 17, 1970, to examine the long delay of the…

  17. An Examination of the Changing Hydrological Environment in Choctaw County Mississippi since 1995, With a Focus on an Area Surrounding an Industrial Complex established in 1998.

    NASA Astrophysics Data System (ADS)

    Foote, J.; Schmitz, D.

    2015-12-01

    Since 1995, Choctaw County in Mississippi has experienced a number of major changes, including population growth and the addition to industrial complexes, including surface mining. The growth of population can put a strain on the available surface and ground water drinking resources. The use of the water resources by the industrial complexes by altering the landscape above and around the water resources can further strain the water supply, as well as affect the water chemistry. The population and industrial complexes of Choctaw County utilizes much of its water from an aquifer system in the Tertiary age Wilcox unit of the Mississippi Embayment, which includes the Meridian Upper-Wilcox Aquifer, the Middle Wilcox Aquifer and the Lower Wilcox Aquifer. Utilizing 20 years of physical chemistry (P-Chem) analysis and potentiometric ground water level records of Choctaw County public water wells as well as industrial P-Chem analysis and surface water and ground water level records from Choctaw County, this study examined the changes to the hydrological environment that has taken place since the increase in population and addition of significant additional industries since 1995. Analysis of the surface and groundwater data shows that over the last 20 years, there has been a drop in the potentiometric surface of the Meridian Upper Wilcox Aquifer, Middle Wilcox Aquifer, and the Lower Wilcox Aquifer. The analysis also shows changes in the in the water chemistry of the surface and ground water supplies, changes such as a general decrease in free carbon dioxide, a decrease in chloride, and fluxuations in the Alkalinity (T) as CaCO­3.

  18. Industry Employment

    ERIC Educational Resources Information Center

    Occupational Outlook Quarterly, 2010

    2010-01-01

    This article illustrates projected employment change from an industry perspective over the 2008-2018 decade. Workers are grouped into an industry according to the type of good produced or service provided by the establishment in which they work. Industry employment projections are shown in terms of numeric change (growth or decline in the total…

  19. [Engineering education reform plan created by Prof. Dr. Shimizu and establishment of Nagoya Municipal Science Museum--regarding cooperative education between universities and industries in Japan after the Second World War].

    PubMed

    Mabuchi, Koichi

    2014-07-01

    This paper gives an account of Prof. Dr. Kinji Shimizu, the first president of Nagoya Institute of Technology, and his establishment of Nagoya Municipal Science Museum. After graduating from the Electrical Engineering Department of Kyoto Imperial University in 1923, Shimizu was impressed by the German Museum in Munich during his stay there as a student in 1932. It's the first time that he learned the education in cooperation with industries. Just after the Second World War, he became director general of the Ministry of Education. However, new education system given by the United States focused not on developing practical ability but on gaining the basic knowledge, which is contrary to what he expected. Then, he contributed to the establishment of the Japanese Society for Engineering Education, besides working as the president of Nagoya Institute of Technology in the earlier 1950s. His idea was supported by industries for the economic growth. Throughout his career, Prof. Dr. Shimizu was convinced that practical engineering education would benefit Japan, and wanted to introduce cooperative education between universities and industries, along the lines of the same system in Germany and the United States. With this vision he founded Nagoya Municipal Science Museum in cooperation with local industries and local government as his final achievement. The museum was completed in 1964. PMID:25296516

  20. [Engineering education reform plan created by Prof. Dr. Shimizu and establishment of Nagoya Municipal Science Museum--regarding cooperative education between universities and industries in Japan after the Second World War].

    PubMed

    Mabuchi, Koichi

    2014-07-01

    This paper gives an account of Prof. Dr. Kinji Shimizu, the first president of Nagoya Institute of Technology, and his establishment of Nagoya Municipal Science Museum. After graduating from the Electrical Engineering Department of Kyoto Imperial University in 1923, Shimizu was impressed by the German Museum in Munich during his stay there as a student in 1932. It's the first time that he learned the education in cooperation with industries. Just after the Second World War, he became director general of the Ministry of Education. However, new education system given by the United States focused not on developing practical ability but on gaining the basic knowledge, which is contrary to what he expected. Then, he contributed to the establishment of the Japanese Society for Engineering Education, besides working as the president of Nagoya Institute of Technology in the earlier 1950s. His idea was supported by industries for the economic growth. Throughout his career, Prof. Dr. Shimizu was convinced that practical engineering education would benefit Japan, and wanted to introduce cooperative education between universities and industries, along the lines of the same system in Germany and the United States. With this vision he founded Nagoya Municipal Science Museum in cooperation with local industries and local government as his final achievement. The museum was completed in 1964.

  1. Establishment of selected baseline blood chemistry and hematologic parameters in captive and wild-caught African white-backed vultures (Gyps africanus).

    PubMed

    Naidoo, V; Diekmann, M; Wolters, K; Swan, G E

    2008-07-01

    Despite the devastating collapse of three vulture populations on the Asian subcontinent as a result of their exposure to diclofenac, there is little available information on the normal physiology of many vulture species, including the African White-backed Vulture (Gyps africanus). Such information is needed to fully understand mechanisms for toxicity and to identify and prevent future health problems. The aim of this study was to establish baseline parameters for hematologic and selected serum chemistry parameters for this model species for further studies into the toxicity of diclofenac. Captive nonreleasable and wild African White-backed Vultures were used to determine reference values. For hematology, erythrocyte counts, hemoglobin concentration, hematocrit, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin concentration, and total and differential leukocyte counts were measured. Chemical analytes measured included sodium, potassium, calcium, albumin, and globulin concentrations, aspartate aminotransferase, creatine kinase, and alanine aminotransferase activities. Uric acid and urea concentrations and the urea:uric acid ratio also were evaluated. Values are presented as means, standard deviations, and reference intervals. The serum chemistry parameters selected may provide a starting point for the evaluation of changes in renal and hepatic function; these organ systems are most severely affected by diclofenac. Results were also compared with values reported for G. africanus nestlings, and from these results it is evident that the clinical pathologic parameters are age related. This indicates that the use of nestling values for the evaluation of clinical pathologic findings in adults may be unreliable and could lead to incorrect assumptions. PMID:18689650

  2. Inca of the blood, Inca of the soul: embodiment, emotion, and racialization in the Peruvian mystical tourist industry.

    PubMed

    Hill, Michael

    2008-01-01

    In the context of the globalizing New Age movement and of the "turismo mistico" (mystical tourism) industry emanating from Peru, white and mestizo New Age practitioners and tourists fashion ideologies emphasizing the spiritual energy which supposedly resides in Quechua bodies, even as they freely appropriate Quechua cosmology and ritual for a hybridized New Age Andean spirituality. This case shows how racialized structural inequalities are expressed and experienced by tourists and New Age movement leaders through particular, essentialist representations of the body and through a common repertoire of emotional responses to inequality, commodification, and privilege. The paper provides an ethnographic account of how racialization may be perpetuated, negotiated, and resisted through religious systems, particularly through the work of constructing ideologies and experiences of the body and of emotional subjectivity. PMID:20681090

  3. Inca of the blood, Inca of the soul: embodiment, emotion, and racialization in the Peruvian mystical tourist industry.

    PubMed

    Hill, Michael

    2008-01-01

    In the context of the globalizing New Age movement and of the "turismo mistico" (mystical tourism) industry emanating from Peru, white and mestizo New Age practitioners and tourists fashion ideologies emphasizing the spiritual energy which supposedly resides in Quechua bodies, even as they freely appropriate Quechua cosmology and ritual for a hybridized New Age Andean spirituality. This case shows how racialized structural inequalities are expressed and experienced by tourists and New Age movement leaders through particular, essentialist representations of the body and through a common repertoire of emotional responses to inequality, commodification, and privilege. The paper provides an ethnographic account of how racialization may be perpetuated, negotiated, and resisted through religious systems, particularly through the work of constructing ideologies and experiences of the body and of emotional subjectivity.

  4. Establishment of a simple and rapid identification method for Listeria spp. by using high-resolution melting analysis, and its application in food industry.

    PubMed

    Ohshima, Chihiro; Takahashi, Hajime; Phraephaisarn, Chirapiphat; Vesaratchavest, Mongkol; Keeratipibul, Suwimon; Kuda, Takashi; Kimura, Bon

    2014-01-01

    Listeria monocytogenes is the causative bacteria of listeriosis, which has a higher mortality rate than that of other causes of food poisoning. Listeria spp., of which L. monocytogenes is a member, have been isolated from food and manufacturing environments. Several methods have been published for identifying Listeria spp.; however, many of the methods cannot identify newly categorized Listeria spp. Additionally, they are often not suitable for the food industry, owing to their complexity, cost, or time consumption. Recently, high-resolution melting analysis (HRMA), which exploits DNA-sequence differences, has received attention as a simple and quick genomic typing method. In the present study, a new method for the simple, rapid, and low-cost identification of Listeria spp. has been presented using the genes rarA and ldh as targets for HRMA. DNA sequences of 9 Listeria species were first compared, and polymorphisms were identified for each species for primer design. Species specificity of each HRM curve pattern was estimated using type strains of all the species. Among the 9 species, 7 were identified by HRMA using rarA gene, including 3 new species. The remaining 2 species were identified by HRMA of ldh gene. The newly developed HRMA method was then used to assess Listeria isolates from the food industry, and the method efficiency was compared to that of identification by 16S rDNA sequence analysis. The 2 methods were in coherence for 92.6% of the samples, demonstrating the high accuracy of HRMA. The time required for identifying Listeria spp. was substantially low, and the process was considerably simplified, providing a useful and precise method for processing multiple samples per day. Our newly developed method for identifying Listeria spp. is highly valuable; its use is not limited to the food industry, and it can be used for the isolates from the natural environment.

  5. [Intelligence and neurocognitive tests among students living in a industrialized region of Sardinia with relatively low blood levels of lead].

    PubMed

    Carta, Plinio; Aru, Gabriella; Carta, Laura; Carta, Roberta; Ibba, Antonio

    2013-01-01

    In several recent epidemiological studies blood lead levels (BLLs) even below the current CDC intervention level of 10 microg/dl have been associated with reduced neurocognitive capacities of children, with no clear evidence of a "safe" threshold. We analyzed the relationship between the BLLs and the neurocognitive capacities of 205 Sardinian students aged 11 to 15 years, using 2 tests of the Swedish Performance Evaluating System (SPES) and the full-scale Intelligence Quotient (IQ) derived from the Wechsler Intelligence Scale for Children (WISC). The studied population included 104 children (61 males and 43 females) living in Portoscuso, a town 2 Km far from a lead smelter (mean BLLs: 5.98 +/- 2.2; max 11.5 microg/dl), and 101 age-matched students (55 males and 46 females) living in Sant'Antioco, a town about 20 Km far from the same smelter (mean BLLs: 2.08 +/- 0.8; max 4.5 microg/dl). Subjects with BLLs above 4 microg/dl performed worse in the SPES tests and scored about 5.0 points less on the full-scale IQ compared to the students with lower BLLs. The adjusted regression coefficients derived from the multivariate analysis showed that higher BLLs were significantly associated with worse performances in the SPES tests and with reduced IQ (0.94 points for each microg/dl of BLL). This study confirms the potential neurotoxicity of low-levels of lead suggesting the need of lowering the actual CDC "limit of concern" for children to values lower than 4 microg/dl, improving at the same time the environmental primary prevention for limiting the lead exposure of subjects living near the lead smelter.

  6. Contracting in the national interest: Establishing the legal framework for the interaction of science, government, and industry at a nuclear weapons laboratory

    SciTech Connect

    Furman, N.S.

    1988-04-01

    Sandia National Laboratories, the nation's nuclear ordnance laboratory, is operated on a no-profit, no-fee basis by ATandT Technologies, Inc., as a prime contractor for the Department of Energy. This unique arrangement began in 1949 when President Harry Truman personally requested that ATandT assume management of the nuclear weapons laboratory as a service in the national interest. The story of how this unusual relationship came about makes for an interesting chapter in the annals of US legal and institutional history. This report describes the historical background, political negotiations, and prime contract provisos that established the legal framework for the Labs.

  7. In vivo assessment of an industrial waste product as a feed additive in dairy cows: Effects of larch (Larix decidua L.) sawdust on blood parameters and milk composition.

    PubMed

    Tedesco, D; Garavaglia, L; Spagnuolo, M S; Pferschy-Wenzig, E M; Bauer, R; Franz, C

    2015-12-01

    When larch (Larix spp.) is processed in the wood industry, the sawdust is currently disposed of as waste or used as combustible material, even though it is rich in biologically active compounds. In this study the effect of larch sawdust supplementation on blood parameters as well as milk composition was examined in healthy mid-lactating dairy cows. Twenty-four multiparous Italian Friesian dairy cows were assigned to groups receiving either 300 g/day/cow of larch sawdust or a control diet, and treatments were continued for a 20 day period. Milk parameters were unaffected by treatment. A lower plasma total protein concentration was observed and can be attributed to a decrease in globulin concentration. A lower plasma urea concentration was also detected in the larch group. Moreover, biomarkers of liver function were influenced by the treatment. Total bilirubin was lower in larch-treated animals, and cholesterol tended to be lower. In addition, an interaction between day and treatment was observed for very low density lipoprotein. The concentration of other parameters, including reactive oxygen metabolites, superoxide dismutase, glutathione peroxidase and nitrotyrosine, did not differ between treatments. The observed benefits, together with the good palatability, make larch sawdust a promising candidate for the development of beneficial feed supplements for livestock. Further studies will be useful, particularly to evaluate its efficacy in different health conditions. PMID:26526868

  8. Establishing operations

    PubMed Central

    Michael, Jack

    1993-01-01

    The first two books on behavior analysis (Skinner, 1938; Keller & Schoenfeld, 1950) had chapter-length coverage of motivation. The next generation of texts also had chapters on the topic, but by the late 1960s it was no longer being given much treatment in the behavior-analytic literature. The present failure to deal with the topic leaves a gap in our understanding of operant functional relations. A partial solution is to reintroduce the concept of the establishing operation, defined as an environmental event, operation, or stimulus condition that affects an organism by momentarily altering (a) the reinforcing effectiveness of other events and (b) the frequency of occurrence of that part of the organism's repertoire relevant to those events as consequences. Discriminative and motivative variables can be distinguished as follows: The former are related to the differential availability of an effective form of reinforcement given a particular type of behavior; the latter are related to the differential reinforcing effectiveness of environmental events. An important distinction can also be made between unconditioned establishing operations (UEOs), such as food deprivation and painful stimulation, and conditioned establishing operations (CEOs) that depend on the learning history of the organism. One type of CEO is a stimulus that has simply been paired with a UEO and as a result may take on some of the motivative properties of that UEO. The warning stimulus in avoidance procedures is another important type of CEO referred to as reflexive because it establishes its own termination as a form of reinforcement and evokes the behavior that has accomplished such termination. Another CEO is closely related to the concept of conditional conditioned reinforcement and is referred to as a transitive CEO, because it establishes some other stimulus as a form of effective reinforcement and evokes the behavior that has produced that other stimulus. The multiple control of human

  9. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Blood storage refrigerator and blood storage... Establishments That Manufacture Blood and Blood Products § 864.9700 Blood storage refrigerator and blood storage freezer. (a) Identification. A blood storage refrigerator and a blood storage freezer are devices...

  10. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Blood storage refrigerator and blood storage... Establishments That Manufacture Blood and Blood Products § 864.9700 Blood storage refrigerator and blood storage freezer. (a) Identification. A blood storage refrigerator and a blood storage freezer are devices...

  11. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Blood storage refrigerator and blood storage... Establishments That Manufacture Blood and Blood Products § 864.9700 Blood storage refrigerator and blood storage freezer. (a) Identification. A blood storage refrigerator and a blood storage freezer are devices...

  12. 21 CFR 864.9700 - Blood storage refrigerator and blood storage freezer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Blood storage refrigerator and blood storage... Establishments That Manufacture Blood and Blood Products § 864.9700 Blood storage refrigerator and blood storage freezer. (a) Identification. A blood storage refrigerator and a blood storage freezer are devices...

  13. Lead levels - blood

    MedlinePlus

    Blood lead levels ... is used to screen people at risk for lead poisoning. This may include industrial workers and children ... also used to measure how well treatment for lead poisoning is working. Lead is common in the ...

  14. Vomiting blood

    MedlinePlus

    ... first part of the small intestine, or esophagus Blood clotting disorders Defects in the blood vessels of the ... as a complete blood count (CBC), blood chemistries, blood clotting tests, and liver function tests Esophagogastroduodenoscopy (EGD) (placing ...

  15. Blood Disorders

    MedlinePlus

    ... liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets. Blood disorders affect ...

  16. Money for Blood and Markets for Blood.

    PubMed

    Derpmann, Simon; Quante, Michael

    2015-12-01

    Ontario's Bill 178 proposing a Voluntary Blood Donations Act declares the offer or acceptance of payment for the donation of blood a legal offence and makes it subject to penalty. The bill reinvigorates a fundamental debate about the ethical problems associated with the payment of money for blood. Scarcity of blood donors is a recurring problem in most health systems, and monetary remuneration of the willingness to donate blood is regularly discussed--and sometimes practiced--as a means to overcome scarcity in blood. However, making blood an object of economic exchange has long aroused ethical concerns that often refer to the specific meaning of blood. From the perspective of a modern understanding of money as a metric of economic value, the exchange of money for blood--shed or given--is seen as ethically troubling, because it appears to imply a commensurability of the value of human life and economic wealth. In this paper, we begin with a general taxonomy of the types of arguments that speak in favour or against compensating donors for giving blood. We then describe the context in which the discussion about payment for blood arises, and of the specific aims and concerns that are brought forward in this context. This is used to reconstruct the normative background that supports the rejection of payment for blood as it is envisaged in Bill 178 and the aims of the proposal. We then argue that while a payment indeed changes the nature of a blood donation in an ethically considerable way, we do not believe that decisive arguments against the monetary remuneration of blood donations can be substantiated, at least not independently of assuming specific societal circumstances. Thus it may be possible to establish a stable and safe blood supply through just gratification while at the same time taking strong provisions against social disconnection, injustice, exploitation or heteronomy.

  17. Blood clotting

    MedlinePlus Videos and Cool Tools

    ... the external bleeding stops. Clotting factors in the blood cause strands of blood-borne material, called fibrin, to stick together and ... the inside of the wound. Eventually, the cut blood vessel heals, and the blood clot dissolves after ...

  18. Agriculture--Industry of the Future

    SciTech Connect

    2001-01-23

    This 8-page brochure describes the Office of Industrial Technologies' Agriculture Industry of the Future, a partnership between the Department of Energy and the agriculture industry established to increase industrial energy and cost efficiency.

  19. Petroleum--Industry of the Future

    SciTech Connect

    2001-01-23

    This 8-page brochure describes the Office of Industrial Technologies' Petroleum Industry of The Future, a partnership between the Department of Energy and the petroleum refining industry established to increase industrial energy and cost efficiency.

  20. Blood pressure

    MedlinePlus Videos and Cool Tools

    ... called diastole. Normal blood pressure is considered to be a systolic blood pressure of 115 millimeters of ... pressure reading of 140 over 90, he would be evaluated for having high blood pressure. If left ...

  1. Blood Sugar

    MedlinePlus

    Blood sugar, or glucose, is the main sugar found in your blood. It comes from the food you eat, and is your body's main source of energy. Your blood carries glucose to all of your body's cells to use ...

  2. Immunoelectrophoresis - blood

    MedlinePlus

    IEP - serum; Immunoglobulin electrophoresis - blood; Gamma globulin electrophoresis; Serum immunoglobulin electrophoresis ... A blood sample is needed. For information on how this is done, see: Venipuncture

  3. 77 FR 40068 - Draft Guidance for Industry: Recommendations for Donor Questioning, Deferral, Reentry, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... Questioning, Deferral, Reentry, and Product Management To Reduce the Risk of Transfusion-Transmitted Malaria...-Transmitted Malaria'' dated June 2012. The draft guidance document provides blood establishments that collect... malaria. This guidance replaces the draft guidance entitled ``Guidance for Industry: Recommendations...

  4. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  5. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  6. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  7. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  8. 21 CFR 607.30 - Updating blood product listing information.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Updating blood product listing information. 607.30... (CONTINUED) BIOLOGICS ESTABLISHMENT REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.30 Updating blood...

  9. Blood-related proteomics.

    PubMed

    Liumbruno, Giancarlo; D'Alessandro, Angelo; Grazzini, Giuliano; Zolla, Lello

    2010-01-01

    Blood-related proteomics is an emerging field, recently gaining momentum. Indeed, a wealth of data is now available and a plethora of groups has contributed to add pieces to the jigsaw puzzle of protein complexity within plasma and blood cells. In this review article we purported to sail across the mare magnum of the actual knowledge in this research endeavour. The main strides in proteomic investigations on red blood cells, platelets, plasma and white blood cells are hereby presented in a chronological order. Moreover, a glance is given at prospective studies which promise to shift the focus of attention from the end product to its provider, the donor, in a sort of Kantian "Copernican revolution". A well-rounded portrait of the usefulness of proteomics in blood-related research is accurately given. In particular, proteomic tools could be adopted to follow the main steps of the blood-banking production processes (a comparison of collection methods, pathogen inactivation techniques, storage protocols). Thus proteomics has been recently transformed from a mere basic-research extremely-expensive toy into a dramatically-sensitive and efficient eye-lens to either delve into the depths of the molecular mechanisms of blood and blood components or to establish quality parameters in the blood-banking production chain totally anew. PMID:19567275

  10. Industrial alliances

    SciTech Connect

    Adams, K.V.

    1993-09-13

    The United States is emerging from the Cold War era into an exciting, but challenging future. Improving the economic competitiveness of our Nation is essential both for improving the quality of life in the United States and maintaining a strong national security. The research and technical skills used to maintain a leading edge in defense and energy now should be used to help meet the challenge of maintaining, regaining, and establishing US leadership in industrial technologies. Companies recognize that success in the world marketplace depends on products that are at the leading edge of technology, with competitive cost, quality, and performance. Los Alamos National Laboratory and its Industrial Partnership Center (IPC) has the strategic goal to make a strong contribution to the nation`s economic competitiveness by leveraging the government`s investment at the Laboratory: personnel, infrastructure, and technological expertise.

  11. Analytical model for calculating indeterminate results interval of screening tests, the effect on seroconversion window period: a brief evaluation of the impact of uncertain results on the blood establishment budget.

    PubMed

    Pereira, Paulo; Westgard, James O; Encarnação, Pedro; Seghatchian, Jerard

    2014-10-01

    The evaluation of measurement uncertainty is not required by the European Union regulation or blood establishments’ laboratory tests. However, it is required for tests accredited by ISO 15189. Also, the forthcoming ISO 9001 edition requires “risk based thinking” with risk described as “the effect of uncertainty on an expected result”. ISO recommends GUM models for determination of measurement uncertainty, but their application is not intended for ordinal value measurements, such as what happens with screening test binary results. This article reviews, discusses and proposes concepts intended for measurement uncertainty of screening test results. The precision model focuses on cutoff level allowing the evaluation of the indeterminate interval using analytical sources of variance. The intervalis considered in the estimation of the seroconversion window period. The delta-value of patients and healthy subjects’ samples allows ranking two tests according to the probability of the two classes of indeterminate results: chance of false negative results and chance of false positive results (waste on budget).

  12. Analytical model for calculating indeterminate results interval of screening tests, the effect on seroconversion window period: a brief evaluation of the impact of uncertain results on the blood establishment budget.

    PubMed

    Pereira, Paulo; Westgard, James O; Encarnação, Pedro; Seghatchian, Jerard

    2014-10-01

    The evaluation of measurement uncertainty is not required by the European Union regulation or blood establishments’ laboratory tests. However, it is required for tests accredited by ISO 15189. Also, the forthcoming ISO 9001 edition requires “risk based thinking” with risk described as “the effect of uncertainty on an expected result”. ISO recommends GUM models for determination of measurement uncertainty, but their application is not intended for ordinal value measurements, such as what happens with screening test binary results. This article reviews, discusses and proposes concepts intended for measurement uncertainty of screening test results. The precision model focuses on cutoff level allowing the evaluation of the indeterminate interval using analytical sources of variance. The intervalis considered in the estimation of the seroconversion window period. The delta-value of patients and healthy subjects’ samples allows ranking two tests according to the probability of the two classes of indeterminate results: chance of false negative results and chance of false positive results (waste on budget). PMID:25457752

  13. Blood Typing

    MedlinePlus

    ... this page helpful? Also known as: Blood Group; Rh Factor Formal name: ABO Group and Rh Type Related ... mother's and baby's ABO blood groups, not the Rh factor. However, ABO grouping cannot be used to predict ...

  14. Blood smear

    MedlinePlus

    Peripheral smear; Complete blood count - peripheral; CBC - peripheral ... Bain BJ. The peripheral blood smear. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier; 2016:chap 157. ...

  15. Blood Thinners

    MedlinePlus

    ... it takes to form a blood clot. Antiplatelet drugs, such as aspirin, prevent blood cells called platelets ... that your healthcare provider knows all of the medicines and supplements you are using.

  16. What's Blood?

    MedlinePlus

    ... You know what blood is — it's that red stuff that oozes out if you get a paper ... ingredients. It makes them. Bone marrow — that goopy stuff inside your bones — makes the red blood cells, ...

  17. Blood transfusions

    MedlinePlus

    ... matches yours. You may have read about the danger of becoming infected with hepatitis, HIV, or other ... member or friend donating blood before a planned surgery. This blood is then set aside and held ...

  18. 21 CFR 864.9100 - Empty container for the collection and processing of blood and blood components.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of blood and blood components. 864.9100 Section 864.9100 Food and Drugs FOOD AND DRUG ADMINISTRATION... Used In Establishments That Manufacture Blood and Blood Products § 864.9100 Empty container for the collection and processing of blood and blood components. (a) Identification. An empty container for...

  19. 21 CFR 864.9100 - Empty container for the collection and processing of blood and blood components.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of blood and blood components. 864.9100 Section 864.9100 Food and Drugs FOOD AND DRUG ADMINISTRATION... Used In Establishments That Manufacture Blood and Blood Products § 864.9100 Empty container for the collection and processing of blood and blood components. (a) Identification. An empty container for...

  20. 21 CFR 864.9100 - Empty container for the collection and processing of blood and blood components.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of blood and blood components. 864.9100 Section 864.9100 Food and Drugs FOOD AND DRUG ADMINISTRATION... Used In Establishments That Manufacture Blood and Blood Products § 864.9100 Empty container for the collection and processing of blood and blood components. (a) Identification. An empty container for...

  1. 21 CFR 864.9100 - Empty container for the collection and processing of blood and blood components.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of blood and blood components. 864.9100 Section 864.9100 Food and Drugs FOOD AND DRUG ADMINISTRATION... Used In Establishments That Manufacture Blood and Blood Products § 864.9100 Empty container for the collection and processing of blood and blood components. (a) Identification. An empty container for...

  2. 21 CFR 864.9100 - Empty container for the collection and processing of blood and blood components.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of blood and blood components. 864.9100 Section 864.9100 Food and Drugs FOOD AND DRUG ADMINISTRATION... Used In Establishments That Manufacture Blood and Blood Products § 864.9100 Empty container for the collection and processing of blood and blood components. (a) Identification. An empty container for...

  3. 7 CFR 1217.40 - Establishment and membership.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., PROMOTION, CONSUMER EDUCATION AND INDUSTRY INFORMATION ORDER Softwood Lumber Research, Promotion, Consumer Education, and Industry Information Order Definitions § 1217.40 Establishment and membership. (a..., Colorado, Hawaii, Idaho, Montana, Nevada, New Mexico, North Dakota, Oregon, South Dakota, Utah,...

  4. 7 CFR 1217.40 - Establishment and membership.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., PROMOTION, CONSUMER EDUCATION AND INDUSTRY INFORMATION ORDER Softwood Lumber Research, Promotion, Consumer Education, and Industry Information Order Definitions § 1217.40 Establishment and membership. (a..., Arizona, California, Colorado, Hawaii, Idaho, Montana, Nevada, New Mexico, North Dakota, Oregon,...

  5. 7 CFR 1217.40 - Establishment and membership.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., PROMOTION, CONSUMER EDUCATION AND INDUSTRY INFORMATION ORDER Softwood Lumber Research, Promotion, Consumer Education, and Industry Information Order Definitions § 1217.40 Establishment and membership. (a..., Colorado, Hawaii, Idaho, Montana, Nevada, New Mexico, North Dakota, Oregon, South Dakota, Utah,...

  6. Photonic non-contact estimation of blood lactate level.

    PubMed

    Abraham, Chen; Beiderman, Yevgeny; Ozana, Nisan; Tenner, Felix; Schmidt, Michael; Sanz, Martin; Garcia, Javier; Zalevsky, Zeev

    2015-10-01

    The ability to measure the blood lactate level in a non-invasive, non-contact manner is very appealing to the sports industry as well as the home care field. That is mainly because this substance level is an imperative parameter in the course of devolving a personal workout programs. Moreover, the blood lactate level is also a pivotal means in estimation of muscles' performance capability. In this manuscript we propose an optical non-contact approach to estimate the concentration level of this parameter. Firstly, we introduce the connection between the physiological muscle tremor and the lactate blood levels. Secondly, we suggest a photonic optical method to estimate the physiological tremor. Lastly, we present the results of tests conducted to establish proof of concept to this connection. PMID:26504661

  7. Moving East: how the transnational tobacco industry gained entry to the emerging markets of the former Soviet Union—part II: an overview of priorities and tactics used to establish a manufacturing presence

    PubMed Central

    Gilmore, A; McKee, M

    2004-01-01

    Objectives: To explore how British American Tobacco (BAT), having established cigarette imports, responded to the opportunities for investment in cigarette manufacturing in the former Soviet Union (FSU). Design: Analysis of documents held at the BAT archive in Guildford, UK. Results: Considerable priority was attached to investing in the FSU. This led BAT to undertake a major organisational change and to intense competition to acquire assets. BAT used flawed economic arguments to persuade cash starved governments that its investment would reap economic rewards. It offered excise advice that disadvantaged governments while benefiting BAT, confused issues over pricing, and avoided competitive tendering. BAT targeted agriculture ministries, using its expertise in leaf production to differentiate itself from other potential investors. It subverted the principles of corporate social responsibility to promote itself as a business partner. BAT's task was made easier by the naivety of post-Soviet governments and by the international financial organisations' support for rapid economic reform. The latter permitted tobacco transnationals to penetrate markets before effective competitive tendering processes had been established, giving them the opportunity to minimise prices and establish monopolies. Conclusions: Many of the arguments employed when penetrating post-Soviet markets were highly misleading but governments lacked expertise to realise this. There is a need to build tobacco control capacity in transition economies, within and outside government, to ensure that governments are better informed of the true economic and health impacts of tobacco. Rapid transition from socialist to market economies without establishing regulatory institutional structures may be dangerous when investing companies use business practices that fall short of international standards. PMID:15175532

  8. Blood Supply.

    PubMed

    Kubo, Keitaro

    2016-01-01

    It has been suggested that blood circulation within the tendons contributes to repair of the tendon after the exercises. Recently, blood circulation of human tendons could be measured using red laser lights (Kubo et al. 2008b). Using this technique, we were able to measure changes in blood volume and oxygen saturation of human tendons by various treatments. During a 60-min heating, the blood volume and oxygen saturation of the tendon increased significantly from the resting level, and continued to increase by 35 min. These changes in blood circulation of tendon were considerably different from the temperatures of muscle and skin. Furthermore, when the needle tip was moved up and down from the targeted depth (up-and-down manipulation) at approximately 1 mm amplitude, the blood volume and oxygen saturation of the treated tendon increased significantly. After the removal of the acupuncture needle, the blood volume and oxygen saturation of the tendon increased gradually for the non-treated side. These results suggested that the change in blood circulation of the tendon during acupuncture with up-and-down manipulation was caused by axon reflex, and increase in blood flow in the tendons after the needle removal might be caused through the central nervous system. It is well known that heating and acupuncture treatments were quite effective in the management of tendon injuries. Therefore, these phenomena would be related to the changes in blood circulation of tendons due to heating and acupuncture treatments. PMID:27535246

  9. Blood Supply.

    PubMed

    Kubo, Keitaro

    2016-01-01

    It has been suggested that blood circulation within the tendons contributes to repair of the tendon after the exercises. Recently, blood circulation of human tendons could be measured using red laser lights (Kubo et al. 2008b). Using this technique, we were able to measure changes in blood volume and oxygen saturation of human tendons by various treatments. During a 60-min heating, the blood volume and oxygen saturation of the tendon increased significantly from the resting level, and continued to increase by 35 min. These changes in blood circulation of tendon were considerably different from the temperatures of muscle and skin. Furthermore, when the needle tip was moved up and down from the targeted depth (up-and-down manipulation) at approximately 1 mm amplitude, the blood volume and oxygen saturation of the treated tendon increased significantly. After the removal of the acupuncture needle, the blood volume and oxygen saturation of the tendon increased gradually for the non-treated side. These results suggested that the change in blood circulation of the tendon during acupuncture with up-and-down manipulation was caused by axon reflex, and increase in blood flow in the tendons after the needle removal might be caused through the central nervous system. It is well known that heating and acupuncture treatments were quite effective in the management of tendon injuries. Therefore, these phenomena would be related to the changes in blood circulation of tendons due to heating and acupuncture treatments.

  10. Blood groups and filariasis.

    PubMed

    Kumar, H; Santhanam, S

    1989-01-01

    Only a little is known about the studies done with filariasis in relation to blood groups. The present communication reports the results of a preliminary study carried out to investigate any relationship of ABO and Rho(D) blood groups in persons with circulating microfilariae (mf) in blood and with disease manifestations compared with healthy normal controls within a population in similar epidemiological and ecological conditions. Blood groups ABO and Rho(D) were investigated among 271 persons with filarial disease and 172 normal subjects from an endemic area of bancroftian filariasis. No relationship was observed between infection and blood groups. It appeared that blood groups and filarial infection were independent of each other. Also the sex of the individual and stage of the infection, i.e. persons with circulating mf only without manifestations and persons with established manifestation without mf, has no bearing on blood group inheritance. There were 95.05% of Rh-positive and 4.95% of Rh-negative persons in the whole studied population. The observations are similar to other studies.

  11. Blood Analyzer

    NASA Technical Reports Server (NTRS)

    1992-01-01

    In the 1970's, NASA provided funding for development of an automatic blood analyzer for Skylab at the Oak Ridge National Laboratory (ORNL). ORNL devised "dynamic loading," which employed a spinning rotor to load, transfer, and analyze blood samples by centrifugal processing. A refined, commercial version of the system was produced by ABAXIS and is marketed as portable ABAXIS MiniLab MCA. Used in a doctor's office, the equipment can perform 80 to 100 chemical blood tests on a single drop of blood and report results in five minutes. Further development is anticipated.

  12. High Blood Pressure

    MedlinePlus

    ... version High Blood Pressure Overview What is blood pressure? Blood pressure is the amount of force that your ... called your blood pressure. What is high blood pressure? High blood pressure (also called hypertension) occurs when your blood ...

  13. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2001-01-01

    An overview of the industrial diamond industry is provided. More than 90 percent of the industrial diamond consumed in the U.S. and the rest of the world is manufactured diamond. Ireland, Japan, Russia, and the U.S. produce 75 percent of the global industrial diamond output. In 2000, the U.S. was the largest market for industrial diamond. Industrial diamond applications, prices for industrial diamonds, imports and exports of industrial diamonds, the National Defense Stockpile of industrial diamonds, and the outlook for the industrial diamond market are discussed.

  14. Use of agro-industrial organic sludge amendment to remediate degraded soil: chemical and eco(geno)toxicological differences between fresh and stabilized sludge and establishment of application rates.

    PubMed

    Chiochetta, Claudete G; Cotelle, Sylvie; Masfaraud, Jean-François; Toumi, Hela; Quaranta, Gaetana; Adani, Fabrizio; Radetski, Claudemir M

    2016-02-01

    Soil degraded by coal mining activities can be remediated by amendment with agro-industrial organic sludge. However, the environmental impacts associated with this management practice must be properly addressed. In this context, the objective of this study was to evaluate the eco(geno)toxicity of a fresh and a stabilized sludge before use in a laboratory soil remediation test. Chemical analysis of the complex mixtures (degraded soil, fresh sludge, and stabilized sludge) was carried out, as well as a battery of eco(geno)toxicity tests on microbiological enzymes (fluorescein hydrolysis), earthworms, and higher plants (including Vicia faba genotoxicity test), according to published methodologies. The results of these tests showed that fresh sludge was more toxic than sludge stabilized over 6 months toward earthworms and higher plants (lettuce, corn, and wild cabbage), while phyto(geno)toxicity tests with V. faba indicated the same genotoxicity levels for the two types of sludge. In the soil remediation simulation using different mixtures of degraded soil and stabilized sludge, the proportions of 50:50% (dry weight basis) provided the lowest phyto(geno)toxicity effects and this mixture can be used for the revegetation of the contaminated site. PMID:26341335

  15. Use of agro-industrial organic sludge amendment to remediate degraded soil: chemical and eco(geno)toxicological differences between fresh and stabilized sludge and establishment of application rates.

    PubMed

    Chiochetta, Claudete G; Cotelle, Sylvie; Masfaraud, Jean-François; Toumi, Hela; Quaranta, Gaetana; Adani, Fabrizio; Radetski, Claudemir M

    2016-02-01

    Soil degraded by coal mining activities can be remediated by amendment with agro-industrial organic sludge. However, the environmental impacts associated with this management practice must be properly addressed. In this context, the objective of this study was to evaluate the eco(geno)toxicity of a fresh and a stabilized sludge before use in a laboratory soil remediation test. Chemical analysis of the complex mixtures (degraded soil, fresh sludge, and stabilized sludge) was carried out, as well as a battery of eco(geno)toxicity tests on microbiological enzymes (fluorescein hydrolysis), earthworms, and higher plants (including Vicia faba genotoxicity test), according to published methodologies. The results of these tests showed that fresh sludge was more toxic than sludge stabilized over 6 months toward earthworms and higher plants (lettuce, corn, and wild cabbage), while phyto(geno)toxicity tests with V. faba indicated the same genotoxicity levels for the two types of sludge. In the soil remediation simulation using different mixtures of degraded soil and stabilized sludge, the proportions of 50:50% (dry weight basis) provided the lowest phyto(geno)toxicity effects and this mixture can be used for the revegetation of the contaminated site.

  16. Blood gases

    MedlinePlus

    ... are a measurement of how much oxygen and carbon dioxide are in your blood. They also determine the ... oxygen (PaO2): 75 - 100 mmHg Partial pressure of carbon dioxide (PaCO2): 38 - 42 mmHg Arterial blood pH: 7. ...

  17. 76 FR 48167 - Agency Information Collection Activities; Proposed Collection; Comment Request; Blood...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... banks, certain transfusion services, other blood product manufacturers, and independent laboratories... Collection; Comment Request; Blood Establishment Registration and Product Listing, Form FDA 2830 AGENCY: Food... blood establishment registration and product listing requirements in the Agency's regulations and...

  18. Engineering Aspects in Blood Pump Development

    NASA Technical Reports Server (NTRS)

    Golding, Leonard; Veres, Joseph P.

    1997-01-01

    NASA turbomachinery computer codes assisted in the design of the Cleveland Clinic Foundation's centrifugal bladed blood pump. The codes were originally developed for the aerospace industry, but are applicable to the blood pump because of a high degree of synergy with this application. Traditional turbomachinery design criteria were used in the design of the blood pump centrifugal impeller and volute casing. The fluid dynamic performance of the blood pump is meeting the engineering design goals of flow rate and pressure rise.

  19. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2001-01-01

    A general overview of the industrial garnet industry is provided. About 20 percent of global industrial garnet production takes place in the U.S. During 2000, an estimated 300 kt of industrial garnets were produced worldwide. The U.S. is the world's largest consumer of industrial garnet, consuming 56.9 kt in 2000.

  20. 21 CFR 864.9050 - Blood bank supplies.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Blood bank supplies. 864.9050 Section 864.9050...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9050 Blood bank supplies. (a) Identification. Blood bank supplies are...

  1. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  2. 21 CFR 864.9050 - Blood bank supplies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Blood bank supplies. 864.9050 Section 864.9050...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9050 Blood bank supplies. (a) Identification. Blood bank supplies are...

  3. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  4. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  5. 21 CFR 864.9050 - Blood bank supplies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Blood bank supplies. 864.9050 Section 864.9050...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9050 Blood bank supplies. (a) Identification. Blood bank supplies are...

  6. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  7. 21 CFR 864.9050 - Blood bank supplies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Blood bank supplies. 864.9050 Section 864.9050...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9050 Blood bank supplies. (a) Identification. Blood bank supplies are...

  8. 21 CFR 864.9185 - Blood grouping view box.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Blood grouping view box. 864.9185 Section 864.9185...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9185 Blood grouping view box. (a) Identification. A blood grouping view...

  9. 21 CFR 864.9050 - Blood bank supplies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Blood bank supplies. 864.9050 Section 864.9050...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Products Used In Establishments That Manufacture Blood and Blood Products § 864.9050 Blood bank supplies. (a) Identification. Blood bank supplies are...

  10. British Industrial Libraries Before 1939

    ERIC Educational Resources Information Center

    Marshall, Margaret R.

    1972-01-01

    British industrial firm libraries are traced from their beginnings till 1939, by which date they had spread to many branches of industry and had been recognized as an important part of the industrial and library worlds, thus establishing standard patterns of work. The origins and significance of Aslib are discussed. (27 references) (Author/NH)

  11. Establishment and Characterization of a Newly Established Diabetic Gerbil Line

    PubMed Central

    Li, Xiaohong; Lu, Jing; Wang, Ying; Huo, Xueyun; Li, Zhenkun; Zhang, Shuangyue; Li, Changlong; Guo, Meng; Du, Xiaoyan; Chen, Zhenwen

    2016-01-01

    Objectives We aimed to selectively breed a spontaneous diabetic gerbil when a sub-line of inbred gerbil showed increased blood glucose levels was found recently. Then we investigated the characteristics including the serum insulin, triglyceride, cholesterol, leptin, adiponectin and explored the underlying molecular mechanism for the diabetic phenotype. Methods The spontaneous diabetic line of gerbils was selectively inbreed the sub-line of gerbil by monitoring blood glucose of each animal. The serum insulin, adiponectin, and leptin levels were tested using an ELISA kit. The expression levels of GLUT4, Akt, leptin, adiponectin, and calpain 10 (CAPN10) were tested by western blot and Quantitative Real-time PCR (qPCR) in liver, skeletal muscle, and white adipose. Results Our results show that the percentages of animals with FPG≥5.2 (mmol/l), PG2h≥6.8 (mmol/l) and both FPG≥5.2 and PG2h≥6.8 (mmol/l) were increased with the number of breeding generations from F0 (21.33%) to F6 (38.46%). These diabetic gerbils exhibited insulin resistance and leptin resistance as well as decreased adiponectin level in the serum. We also observed decreased expression of adiponectin and increased expression of leptin in the skeletal muscle, respectively. Conclusions These results indicate that we have primarily established a spontaneous diabetic gerbil line, and the diabetic phenotypes may have been accounted for by altered expression of leptin and adiponectin. PMID:27427908

  12. The Protestant Establishment Revisited

    ERIC Educational Resources Information Center

    Baltzell, E. Digby

    1976-01-01

    The author's book, "The Protestant Establishment: Aristocracy and Caste in America", is highly critical of the WASP (White-Anglo-Saxon-Protestant) establishment and proposed the development and need for some sort of upper-class ruling-group. Here is a re-evaluation of his book, now thirteen years old, by the author. (Author/RK)

  13. Blood Transfusion

    MedlinePlus

    ... made by the kidneys that stimulates red cell production {{ Immunoglobulins, antibodies made by plasma cells in response ... used for chemotherapy cause temporarily impaired blood cell production in the marrow and depressed immune system functions. ...

  14. Blood typing

    MedlinePlus

    ... whether or not you have a substance called Rh factor on the surface of your red blood cells. If you have this substance, you are considered Rh+ (positive). Those without it are considered Rh- (negative). ...

  15. Moving blood.

    PubMed

    Pelis, K

    1997-01-01

    Our internationally acclaimed journalist Sanguinia has returned safely from her historic assignment. Travelling from Homeric Greece to British Romanticism, she was witness to blood drinking, letting, bathing, and transfusion. In this report, she explores connections between the symbolic and the sadistic; the mythic and the medical--all in an effort to appreciate the layered meanings our culture has given to the movement of blood between our bodies. PMID:9407636

  16. Storing Blood Cells

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The National Cancer Institute worked with Goddard Space Flight Center to propose a solution to the blood-cell freezing problem. White blood cells and bone marrow are stored for future use by leukemia patients as a result of Goddard and Jet Propulsion Laboratory expertise in electronics and cryogenics. White blood cell and bone marrow bank established using freezing unit. Freezing unit monitors temperature of cells themselves. Thermocouple placed against polyethylene container relays temperature signals to an electronic system which controls small heaters located outside container. Heaters allow liquid nitrogen to circulate at constant temperature and maintain consistent freezing rate. Ability to freeze, store, and thaw white cells and bone marrow without damage is important in leukemia treatment.

  17. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2003-01-01

    Statistics on the production, consumption, cost, trade, and government stockpile of natural and synthetic industrial diamond are provided. The outlook for the industrial diamond market is also considered.

  18. Catecholamine blood test

    MedlinePlus

    Norepinephrine -- blood; Epinephrine -- blood; Adrenalin -- blood; Dopamine -- blood ... A blood sample is needed. ... the test. This is especially true if both blood and urine catecholamines are to be measured. You ...

  19. Biology of Blood

    MedlinePlus

    ... Mail Facebook TwitterTitle Google+ LinkedIn Home Blood Disorders Biology of Blood Overview of Blood Resources In This ... Version. DOCTORS: Click here for the Professional Version Biology of Blood Overview of Blood Components of Blood ...

  20. US Army blood program: 2025 and beyond.

    PubMed

    Gonzales, Richard; Taylor, Audra L; Atkinson, Andrew J; Malloy, Wilbur W; Macdonald, Victor W; Cap, Andrew P

    2016-03-01

    In preparing to support the Army in 2025 and beyond, the Army Blood Program remains actively engaged with the research and advanced development of blood products and medical technology to improve blood safety and efficacy in conjunction with the US Army Medical Research and Materiel Command. National and International Blood Bank authorities have noted that the US Army research and development efforts in providing new blood products and improving blood safety operate on the cutting edge of technology and are transformational for the global blood industry. Over the past 14 years, the Army has transformed how blood support is provided and improved the survival rate of casualties. Almost every product or process developed by or for the military has found an application in treating civilian patients. Conflicts have many unwanted consequences; however, in times of conflict, one positive aspect is the identification of novel solutions to improve the safety and efficacy of the blood supply.

  1. Managing your blood sugar

    MedlinePlus

    Hyperglycemia - control; Hypoglycemia - control; Diabetes - blood sugar control; Blood glucose - managing ... Know how to: Recognize and treat low blood sugar (hypoglycemia) Recognize and treat high blood sugar (hyperglycemia) ...

  2. Blood and war.

    PubMed

    Hedley-Whyte, John; Milamed, Debra R

    2010-09-01

    In 1894 Ulsterman and pathologist Almroth Wright described the citation of blood. Twenty-one years later it was introduced into wartime and clinical practice. Harvard Medical School had a large part in providing Colonel Andrew Fullerton, later Professor of Surgery, Queen's Belfast, with the intellectual and practical help for the Allies to deploy blood on the post-Somme Western Front and in Salonika. The key investigators and clinicians were Americans and Canadians who with Fullerton and Wright instructed the Allies. The key enablers were two Harvard-trained surgeons surnamed Robertson-Oswald H. ("Robby") and L. Bruce (no relation). Physician Roger I. Lee of Harvard, surgeon George W Crile of Cleveland, Peyton Rous of the Rockefeller Institute and Richard Lewisohn of Mount Sinai Hospital, both located in the Upper East Side of New York City, played key roles.By Armistice in 1918, indirect citrated nutrient-enhanced blood transfusion was widely used by the Allies. Geoffrey Keynes was taught the techniques of blood transfusion by Dr. Benjamin Harrison Alton of Harvard at a Casualty Clearing Station near Albert at the time of the Battle of Passchendaele. Professor "Robby" Robertson, DSO, Sir Geoffrey Keynes and Sir Thomas Houston established blood banking.

  3. Blood and War

    PubMed Central

    Hedley-Whyte, John; Milamed, Debra R

    2010-01-01

    SUMMARY In 1894 Ulsterman and pathologist Almroth Wright described the citation of blood. Twenty-one years later it was introduced into wartime and clinical practice. Harvard Medical School had a large part in providing Colonel Andrew Fullerton, later Professor of Surgery, Queen's Belfast, with the intellectual and practical help for the Allies to deploy blood on the post-Somme Western Front and in Salonika. The key investigators and clinicians were Americans and Canadians who with Fullerton and Wright instructed the Allies. The key enablers were two Harvard-trained surgeons surnamed Robertson—Oswald H. (“Robby”) and L. Bruce (no relation). Physician Roger I. Lee of Harvard, surgeon George W Crile of Cleveland, Peyton Rous of the Rockefeller Institute and Richard Lewisohn of Mount Sinai Hospital, both located in the Upper East Side of New York City, played key roles. By Armistice in 1918, indirect citrated nutrient-enhanced blood transfusion was widely used by the Allies. Geoffrey Keynes was taught the techniques of blood transfusion by Dr. Benjamin Harrison Alton of Harvard at a Casualty Clearing Station near Albert at the time of the Battle of Passchendaele. Professor “Robby” Robertson, DSO, Sir Geoffrey Keynes and Sir Thomas Houston established blood banking. PMID:22375087

  4. AUDIT OF BLOOD REQUISITION.

    PubMed

    Deb, P; Swarup, D; Singh, M M

    2001-01-01

    A total of 2793 requisition forms received by the blood banks of a Service zonal hospital, between June 1995 and December 1999, were analysed. 1697 (60.71%) forms were demand for single unit blood. Blood was collected against only 1099 forms (39.34%) out of which 713 (64.88%) were single unit issue. Urgency of requirement and blood group of patients was omitted in 56% cases. 104 forms were received without mention of the indications for transfusion. History of previous transfusion and pregnancy/HDN were omitted in 25.1% and 37.38% cases respectively. At an average 14.61% of the total collection was discarded. Of the 292 units discarded, 242 units were due to non utilisation. A transfusion committee should be established in all hospitals with a licensed blood bank. It should constitute definite objectives and conduct regular audits (prospective audit, concurrent review or retrospective review), in order to achieve utmost efficiency and numerous benefits, in terms of workload, cost, errors, risks of transfusion and ultimately increased customer satisfaction. It should strive to abolish single unit and inappropriate transfusion, and advocate autologous transfusion. PMID:27365575

  5. Industrial Minerals

    ERIC Educational Resources Information Center

    Bradbury, James C.

    1978-01-01

    The past year is seen as not particularly good for industrial minerals and for industry in general. Environmental concerns continued to trouble the industry with unacceptable asbestos concentrations and chlorofluorocarbon effects on ozone. A halting U.S. economy also affected industrial progress. (MA)

  6. Blood Clots

    MedlinePlus

    ... and webinars ASH Image Bank Educational Web-based library of hematologic imagery In This Section: Resources for Clinicians Resources for Trainees Resources for Educators Resources for Patients Resources for Industry Professionals View all Guidelines & Quality Care Resources to ...

  7. Blood Basics

    MedlinePlus

    ... and webinars ASH Image Bank Educational Web-based library of hematologic imagery In This Section: Resources for Clinicians Resources for Trainees Resources for Educators Resources for Patients Resources for Industry Professionals View all Guidelines & Quality Care Resources to ...

  8. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2000-01-01

    Part of the 1999 Industrial Minerals Review. A review of the state of the global industrial diamond industry in 1999 is presented. World consumption of industrial diamond has increased annually in recent years, with an estimated 500 million carats valued between $650 million and $800 million consumed in 1999. In 1999, the U.S. was the world's largest market for industrial diamond and was also one of the world's main producers; the others were Ireland, Russia, and South Africa. Uses of industrial diamonds are discussed, and prices of natural and synthetic industrial diamond are reported.

  9. Blood Collection

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The method that is used for the collection, storage and real-time analysis of blood and other bodily fluids has been licensed to DBCD, Inc. by NASA. The result of this patent licensing agreement has been the development of a commercial product that can provide serum or plasma from whole blood volumes of 20 microliters to 4 milliliters. The device has a fibrous filter with a pore size of less than about 3 microns, and is coated with a mixture of mannitol and plasma fraction protein. The coating causes the cellular fraction to be trapped by the small pores, leaving the cellular fraction intact on the fibrous filter while the acellular fraction passes through the filter for collection in unaltered form from the serum sample collection chamber. The method used by this product is useful to NASA for blood analysis on manned space missions.

  10. Blood substitutes.

    PubMed

    Palmer, Andre F; Intaglietta, Marcos

    2014-07-11

    The toxic side effects of early generations of red blood cell substitutes have stimulated development of more safe and efficacious high-molecular-weight polymerized hemoglobins, poly(ethylene glycol)-conjugated hemoglobins, and vesicle-encapsulated hemoglobins. Unfortunately, the high colloid osmotic pressure and blood plasma viscosity of these new-generation materials limit their application to blood concentrations that, in general, are not sufficient for full restoration of oxygen-carrying and -delivery capacity. However, these materials may serve as oxygen therapeutics for treating tissues affected by ischemia and trauma, particularly when the therapeutics are coformulated with antioxidants. These new oxygen therapeutics also possess additional beneficial effects owing to their optimal plasma expansion properties, which induce systemic supraperfusion that increases endothelial nitric oxide production and improves tissue washout of metabolic wastes, further contributing to their therapeutic role.

  11. Industrial applications of nanoparticles.

    PubMed

    Stark, W J; Stoessel, P R; Wohlleben, W; Hafner, A

    2015-08-21

    Research efforts in the past two decades have resulted in thousands of potential application areas for nanoparticles - which materials have become industrially relevant? Where are sustainable applications of nanoparticles replacing traditional processing and materials? This tutorial review starts with a brief analysis on what makes nanoparticles attractive to chemical product design. The article highlights established industrial applications of nanoparticles and then moves to rapidly emerging applications in the chemical industry and discusses future research directions. Contributions from large companies, academia and high-tech start-ups are used to elucidate where academic nanoparticle research has revolutionized industry practice. A nanomaterial-focused analysis discusses new trends, such as particles with an identity, and the influence of modern instrument advances in the development of novel industrial products.

  12. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  13. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  14. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  15. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  16. 21 CFR 607.20 - Who must register and submit a blood product list.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Who must register and submit a blood product list... BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.20 Who must register and submit a blood product list. (a) Owners or operators of all establishments, not exempt...

  17. Blood Types

    MedlinePlus

    ... groups determined by the presence or absence of two antigens – A and B – on the surface of red blood cells: Group A – has only the A antigen on red cells (and B antibody in the plasma) Group B – has only the B antigen on ...

  18. Blood flow

    MedlinePlus Videos and Cool Tools

    As the heart pumps, the arteries carry oxygen-rich blood (shown in red) away from the heart and toward the body's tissues and vital organs. ... brain, liver, kidneys, stomach, and muscles, including the heart muscle itself. At the same time, the veins ...

  19. Establishing American Colleges Abroad.

    ERIC Educational Resources Information Center

    Greene, William E.

    1990-01-01

    Describes the growing involvement of U.S. two-year colleges in establishing programs abroad to enable foreign students to complete one or two years of college-level work in their home country before transferring to U.S. universities. Highlights the activities of several community colleges in the Pacific Rim. Identifies conditions basic to future…

  20. Blood circulation under weightless conditions

    NASA Technical Reports Server (NTRS)

    Kasyan, I. I.; Kopanev, V. I.; Yazdovskiy, V. I.

    1975-01-01

    Biomedical data obtained on men and animals during weightlessness conditions establish instabilities in pulse rate and blood circulation that smooth out in proportion to adaptation to the weightless condition. The unusual slowness of recovery of pulse rate to initial values after space flight stress is attributed to biological simulation of hormonal shifts and discharge of humoral substances into the blood that prevent a rapid recovery of some biological indicators to initial values.

  1. Do blood-borne calcifying nanoparticles self-propagate?

    PubMed Central

    Mathew, Grace; McKay, David S; Çiftçioglu, Neva

    2008-01-01

    The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus, one can easily conjecture the impact of a nanoparticle if it could also self-replicate. This in vitro study reveals the self-propagating ability of unique calcifying nanoparticles (CNP) that can be as small as 50 nm in size and found in blood, blood products, and calcified soft tissues. Although specific detection techniques, morphological characteristics and biomineralizing properties of CNP are well established, their genomic information and self-propagating capability have always been challenged. The objective of this study is to document the propagation of CNP under physiological conditions, using inverted light microscopy (LM) and the Biostation IM time-lapse imaging system. Their detailed morphological structure was examined using scanning (SEM) and transmission (TEM) electron microscopy. This present study, in conjunction with previous findings of metabolic activity, antibiotic sensitivity, antibody specificity, morphological aspects and infectivity, validates CNP as self-replicators. Therefore these sterile-filterable, blood-borne nanoparticles should be of concern to the nanomedicine industry. PMID:18686786

  2. Do blood-borne calcifying nanoparticles self-propagate?

    PubMed

    Mathew, Grace; Mckay, David S; Ciftçioglu, Neva

    2008-01-01

    The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus, one can easily conjecture the impact ofa nanoparticle if it could also self-replicate. This in vitro study reveals the self-propagating ability of unique calcifying nanoparticles (CNP) that can be as small as 50 nm in size and found in blood, blood products, and calcified soft tissues. Although specific detection techniques, morphological characteristics and biomineralizing properties of CNP are well established, their genomic information and self-propagating capability have always been challenged. The objective of this study is to document the propagation of CNP under physiological conditions, using inverted light microscopy (LM) and the Biostation IM time-lapse imaging system. Their detailed morphological structure was examined using scanning (SEM) and transmission (TEM) electron microscopy. This present study, in conjunction with previous findings of metabolic activity, antibiotic sensitivity, antibody specificity, morphological aspects and infectivity, validates CNP as self-replicators. Therefore these sterile-filterable, blood-borne nanoparticles should be of concern to the nanomedicine industry. PMID:18686786

  3. Blood pressure measurement

    MedlinePlus

    Diastolic blood pressure; Systolic blood pressure; Blood pressure reading; Measuring blood pressure ... your health care provider will wrap the blood pressure cuff snugly around your upper arm. The lower ...

  4. High blood pressure - infants

    MedlinePlus

    Hypertension - infants ... and blood vessels The health of the kidneys High blood pressure in infants may be due to kidney or ... blood vessel of the kidney) In newborn babies, high blood pressure is often caused by a blood clot in ...

  5. Blood Pressure Quiz

    MedlinePlus

    ... page please turn Javascript on. Feature: High Blood Pressure Blood Pressure Quiz Past Issues / Fall 2011 Table of Contents ... About High Blood Pressure / Treatment: Types of Blood Pressure Medications / Blood Pressure Quiz Fall 2011 Issue: Volume 6 Number ...

  6. 29 CFR 779.354 - Who may qualify as exempt 13(a)(2) or 13(a)(4) establishments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for resale and are recognized as retail sales of goods or services in the industry. These requirements... establishment is recognized as a retail establishment in the industry (see § 779.347 and paragraph (c) of this...). (c) Establishments recognized as retail in the industry. An establishment which meets...

  7. Establishment of Intestinal Bacteriology

    PubMed Central

    MITSUOKA, Tomotari

    2014-01-01

    Research on intestinal bacteria began around the end of the 19th century. During the last 5 decades of the 20th century, research on the intestinal microbiota made rapid progress. At first, in my work, I first developed a method of comprehensive analysis of the intestinal microbiota, and then I established classification and identification methods for intestinal anaerobes. Using these methods I discovered a number of ecological rules governing the intestinal microbiota and the role of the intestinl microbiota in health and disease. Moreover, using germfree animals, it was proven that the intestinal microbiota has a role in carcinogenesis and aging in the host. Thus, a new interdisciplinary field, “intestinal bacteriology” was established. PMID:25032084

  8. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2004-01-01

    Part of the 2003 industrial minerals review. Supply and demand data for industrial diamond are provided. Topics discussed are consumption, prices, imports and exports, government stockpiles, and the outlook for 2004.

  9. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2012-01-01

    Estimated 2011 world production of natural and synthetic industrial diamond was about 4.45 billion carats. During 2011, natural industrial diamonds were produced in more than 20 countries, and synthetic industrial diamond was produced in at least 13 countries. About 98 percent of the combined natural and synthetic global output was produced in China, Ireland, Japan, Russia, South Africa and the United States. China is the world's leading producer of synthetic industrial diamond followed by Russia and the United States.

  10. Establishment size and risk of occupational injury.

    PubMed

    Oleinick, A; Gluck, J V; Guire, K E

    1995-07-01

    For many years, the annual survey of occupational injuries and illnesses by the Federal Bureau of Labor Statistics (BLS) has consistently reported, without explanation, that injury rates in the smaller establishments (< 50 employees) are substantially lower than those for midsize establishments (100-499 employees). Also during those years, a remarkable increase has been reported in the injury rate in large companies, following the imposition of stiff fines for failure to keep required injury records. The rate patterns are identical for Michigan and the country in general. We investigated possible causes for lower injury rates in small establishments since such rates are inconsistent with reports of higher fatality rates in small establishments in the mining, construction, manufacturing, and transportation industries and higher, or at least comparable, injury rates for small establishments in the mining industry. They are also inconsistent with increased turnover and decreased availability of occupational safety services in small companies. Moreover, injury severity, as measured by missed worktime, is greater for workers in small establishments. We investigated the possibility that interactions of workforce or injury characteristics with establishment size could explain the rate differences. We also reviewed the available literature to see whether differences in labor turnover rates could explain the BLS findings. Graphical and statistical analyses of the 1988 CPS Annual Demographic File, a sample of employed persons in the U.S. workforce, failed to identify any associations between workforce characteristics and enterprise size that would explain the lower rates. Similarly, graphical and statistical analyses of all Michigan workers incurring a compensable injury in 1986 failed to indicate any associations between injury characteristics and establishment size that would explain the lower rates. The potential role of labor turnover on the injury rate was analyzed from

  11. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2006-01-01

    In 2005, estimated world production of natural and synthetic industrial diamond was 630 million carats. Natural industrial diamond deposits were found in more than 35 countries. Synthetic industrial diamond is produced in at least 15 countries. More than 81% of the combined natural and synthetic global output was produced in Ireland, Japan, Russia, South Africa and the United States.

  12. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2011-01-01

    Estimated world production of natural and synthetic industrial diamond was about 4.44 billion carats in 2010. Natural industrial diamond deposits have been found in more than 35 countries, and synthetic industrial diamond is produced in at least 15 countries.

  13. Industrial Microbiology.

    ERIC Educational Resources Information Center

    Demain, Arnold L.; Solomon, Nadine A.

    1981-01-01

    Presents an overview of the field of industrial microbiology, providing historical backgrounds of scientific discoveries in the field and descriptions of industrially important microorganisms. Applied research in industry is also detailed, with mention of gene amplification, DNA recombination, pharmaceutical approaches, and detoxification and…

  14. Industrial Training Handbook.

    ERIC Educational Resources Information Center

    Barber, John W., Ed.

    This industrial training handbook covers the following areas: preparatory considerations; training methods and techniques; training for specific functions; and established organizations. Part I examines the extension and re-designing of technical colleges since the 1920's and the present integration of the work of colleges with the needs of…

  15. LIGA Micromachining: Infrastructure Establishment

    SciTech Connect

    Alfredo M. Morales; Barry V. Hess; Dale R. Boehme; Jill M. Hruby; John S. Krafcik; Robert H. Nilson; Stewart K. Griffiths; William D. Bonivert

    1999-02-01

    LIGA is a micromachining technology that uses high energy x-rays from a synchrotron to create patterns with small lateral dimensions in a deep, non-conducting polymeric resist. Typical dimensions for LIGA parts are microns to tens of microns in lateral size, and hundreds of microns to millimeters in depth. Once the resist is patterned, metal is electrodeposited in the features to create metal microparts, or to create a metal mold for subsequent replication. The acronym LIGA comes from the German words for lithography, electroforming, and molding, and the technology has been under worldwide development for more than a decade. over the last five years, a full-service capability to produce metal microparts using the LIGA process has been established at Sandia national Laboratories, California. This report describes the accomplishments made during the past two years in infrastructure establishment funded by a Laboratory Directed Research and Development (LDRD) project entitled ''LIGA Micromachining.'' Specific topics include photoresist processing for LIGA mask making, x-ray scanning equipment, plating bath instrumentation, plating uniformity, and software architecture.

  16. A changing time: the International Society for Cellular Therapy embraces its industry members.

    PubMed

    Deans, Robert; Gunter, Kurt C; Allsopp, Timothy; Bonyhadi, Mark; Burger, Scott R; Carpenter, Melissa; Clark, Tara; Cox, Charles S; Driscoll, Dawn; Field, Ed; Huss, Ralf; Lardenoije, René; Lodie, Tracey A; Mason, Chris; Neubiser, Richard; Rasko, John E J; Rowley, Jon; Maziarz, Richard T

    2010-11-01

    The last decade has seen a dramatic rise in the development of new cellular therapeutics in a wide range of indications. There have been acceptable safety profiles reported in early studies using blood-derived and adherent stem cell products, but also an inconsistent efficacy record. Further expansion has been hindered in part by a lack of capital (both private and public) and delayed entry into the cell therapy space by large healthcare and pharmaceutical companies, those members of the industry most reliably able to initiate and maintain advanced-phase clinical trials. With recognition that the International Society for Cellular Therapy (ISCT) is uniquely positioned to serve the global translational regenerative medicine research community as a network hub for scientific standards and policy, the ISCT commissioned the establishment of an Industry Task Force (ITF) to address current and future roles for industry. The objectives of the ITF were to gather information and prioritize efforts for a new Commercialization Committee (CC) and to construct innovative platforms that would foster constructive and synergistic collaborations between industry and ISCT. Recommendations and conclusions of the ITF included that the new CC: (1) foster new relationships with therapeutic and stem cell societies, (2) foster educational workshops and forums to cross-educate and standardize practices, (3) create industry subcommittees to address priority initiatives, with clear benchmarks and global implementation, and (4) establish a framework for a greater industry community within ISCT, opening doors for industry to share the new vision for commercialization of cell therapy, emphasizing the regenerative medicine space.

  17. Proteomic Analysis of Menstrual Blood*

    PubMed Central

    Yang, Heyi; Zhou, Bo; Prinz, Mechthild; Siegel, Donald

    2012-01-01

    Menstruation is the expulsion of the endometrial lining of the uterus following a nearly month long preparation for embryo implantation and pregnancy. Increasingly, the health of the endometrium is being recognized as a critical factor in female fertility, and proteomes and transcriptomes from endometrial biopsies at different stages of the menstrual cycle have been studied for both diagnostic and therapeutic purposes (1 Kao, L. C., et al. 2003 Endocrinology 144, 2870–2881; Strowitzki, Tet al. 2006 Hum. Reprod. Update 12, 617–630; DeSouza, L., et al. 2005 Proteomics 5, 270–281). Disorders of the uterus ranging from benign to malignant tumors, as well as endometriosis, can cause abnormal menstrual bleeding and are frequently diagnosed through endometrial biopsy (Strowitzki, Tet al. 2006 Hum. Reprod. Update 12, 617–630; Ferenczy, A. 2003 Maturitas 45, 1–14). Yet the proteome of menstrual blood, an easily available noninvasive source of endometrial tissue, has yet to be examined for possible causes or diagnoses of infertility or endometrial pathology. This study employed five different methods to define the menstrual blood proteome. A total of 1061 proteins were identified, 361 were found by at least two methods and 678 were identified by at least two peptides. When the menstrual blood proteome was compared with those of circulating blood (1774 proteins) and vaginal fluid (823 proteins), 385 proteins were found unique to menstrual blood. Gene ontology analysis and evaluation of these specific menstrual blood proteins identified pathways consistent with the processes of the normal endometrial cycle. Several of the proteins unique to menstrual blood suggest that extramedullary uterine hematopoiesis or parenchymal hemoglobin synthesis may be occurring in late endometrial tissue. The establishment of a normal menstrual blood proteome is necessary for the evaluation of its usefulness as a diagnostic tool for infertility and uterine pathologies. Identification of

  18. 48 CFR 6.202 - Establishing or maintaining alternative sources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... emergency or industrial mobilization; (3) Be in the interest of national defense in establishing or maintaining an essential engineering, research, or development capability to be provided by an educational...

  19. 48 CFR 6.202 - Establishing or maintaining alternative sources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... emergency or industrial mobilization; (3) Be in the interest of national defense in establishing or maintaining an essential engineering, research, or development capability to be provided by an educational...

  20. Industry Invests in Research Centers.

    ERIC Educational Resources Information Center

    Ploch, Margie

    1983-01-01

    Universities and industry are forging new relationships to support academic research and industrial research and development, including the establishment of university/cooperative research centers. Discusses various cooperative projects at these research centers. Includes a list of representative R&D centers in biotechnology, building…

  1. Establishing effective working relationships.

    PubMed

    Houghton, Trish

    2016-02-24

    This article, the second in a series of 11, provides support and offers advice to new and existing mentors and practice teachers to enable them to progress in their role and develop a portfolio of evidence. In particular, the article discusses how to establish effective working relationships and emphasises the importance of the student-mentor or student-practice teacher relationship. It examines the essential qualities, attributes and characteristics of an effective mentor or practice teacher. The article provides learning activities and suggests ways in which mentors and practice teachers can undertake various self-assessments, enabling them to gather relevant evidence to demonstrate how they can meet and maintain the requirements for these roles as stipulated by the Nursing and Midwifery Council.

  2. Establishing Substantial Equivalence: Transcriptomics

    NASA Astrophysics Data System (ADS)

    Baudo, María Marcela; Powers, Stephen J.; Mitchell, Rowan A. C.; Shewry, Peter R.

    Regulatory authorities in Western Europe require transgenic crops to be substantially equivalent to conventionally bred forms if they are to be approved for commercial production. One way to establish substantial equivalence is to compare the transcript profiles of developing grain and other tissues of transgenic and conventionally bred lines, in order to identify any unintended effects of the transformation process. We present detailed protocols for transcriptomic comparisons of developing wheat grain and leaf material, and illustrate their use by reference to our own studies of lines transformed to express additional gluten protein genes controlled by their own endosperm-specific promoters. The results show that the transgenes present in these lines (which included those encoding marker genes) did not have any significant unpredicted effects on the expression of endogenous genes and that the transgenic plants were therefore substantially equivalent to the corresponding parental lines.

  3. Establishing a Presence

    NASA Technical Reports Server (NTRS)

    McCandless, Jeffrey

    2005-01-01

    The basis for this successful collaboration was face-to-face communication. Though it was sometimes stressful being on the road so much, I really learned the importance of being present to work together and ask questions in person. Another measure of success was that in the midst of this project and traveling, my wife and I managed to start a family. My oldest boy got a real kick out of visiting Space Center Houston when he was two to learn all about the "face futtle" which goes way up in the sky. When practical, collocation and face-to-face communication on a project eliminate misunderstandings, establish relationships, make information more easily accessible, and promote a team atmosphere. Compromise is key to balancing both family and career goals. Knowing when to prioritize each is important to success in both aspects.

  4. 7 CFR 63.100 - Establishment and membership.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... hereby established a National Sheep Industry Improvement Center Board. The Board is composed of seven...: (a) Voting members. (1) Four members shall be active producers of sheep or goats in the United...

  5. 7 CFR 63.100 - Establishment and membership.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... hereby established a National Sheep Industry Improvement Center Board. The Board is composed of seven...: (a) Voting members. (1) Four members shall be active producers of sheep or goats in the United...

  6. 7 CFR 63.100 - Establishment and membership.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... hereby established a National Sheep Industry Improvement Center Board. The Board is composed of seven...: (a) Voting members. (1) Four members shall be active producers of sheep or goats in the United...

  7. 7 CFR 63.100 - Establishment and membership.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) NATIONAL SHEEP INDUSTRY... hereby established a National Sheep Industry Improvement Center Board. The Board is composed of seven...: (a) Voting members. (1) Four members shall be active producers of sheep or goats in the United...

  8. Globalisation and blood safety.

    PubMed

    Farrugia, Albert

    2009-05-01

    Globalisation may be viewed as the growing interdependence of countries worldwide through the increasing volume and variety of cross-border transactions in goods and services, and also through the more rapid and widespread diffusion of technology. Globalisation is not just an economic phenomenon, although it is frequently described as such, but includes commerce, disease and travel, and immigration, and as such it affects blood safety and supply in various ways. The relatively short travel times offered by modern aviation can result in the rapid spread of blood-borne pathogens before measures to counteract transmission can be put in place; this would have happened with SARS if the basic life cycle of the SARS virus included an asymptomatic viraemia. This risk can be amplified by ecological factors which effect the spread of these pathogens once they are transferred to a naïve ecosystem, as happened with West Nile Virus (WNV) in North America. The rationalization and contraction of the plasma products industry may be viewed as one aspect of globalisation imposed by the remorseless inevitability of the market; the effect of this development on the safety and supply of products has yet to be seen, but the oversight and assurance of a shrinking number of players will present particular challenges. Similarly, the monopolization of technology, through patent enforcement which puts access beyond the reach of developing countries, can have an effect on blood safety. The challenges presented to blood safety by globalisation are heightening the tensions between the traditional focus on the product safety - zero risk paradigm and the need to view the delivery of safe blood as an integrated process. As an illustration of this tension, donor deferral measures imposed by globalisation-induced risks such as vCJD and WNV have resulted in the loss of the safest and most committed portion of the blood donor population in many Western countries, leading to an increased risk to

  9. Globalisation and blood safety.

    PubMed

    Farrugia, Albert

    2009-05-01

    Globalisation may be viewed as the growing interdependence of countries worldwide through the increasing volume and variety of cross-border transactions in goods and services, and also through the more rapid and widespread diffusion of technology. Globalisation is not just an economic phenomenon, although it is frequently described as such, but includes commerce, disease and travel, and immigration, and as such it affects blood safety and supply in various ways. The relatively short travel times offered by modern aviation can result in the rapid spread of blood-borne pathogens before measures to counteract transmission can be put in place; this would have happened with SARS if the basic life cycle of the SARS virus included an asymptomatic viraemia. This risk can be amplified by ecological factors which effect the spread of these pathogens once they are transferred to a naïve ecosystem, as happened with West Nile Virus (WNV) in North America. The rationalization and contraction of the plasma products industry may be viewed as one aspect of globalisation imposed by the remorseless inevitability of the market; the effect of this development on the safety and supply of products has yet to be seen, but the oversight and assurance of a shrinking number of players will present particular challenges. Similarly, the monopolization of technology, through patent enforcement which puts access beyond the reach of developing countries, can have an effect on blood safety. The challenges presented to blood safety by globalisation are heightening the tensions between the traditional focus on the product safety - zero risk paradigm and the need to view the delivery of safe blood as an integrated process. As an illustration of this tension, donor deferral measures imposed by globalisation-induced risks such as vCJD and WNV have resulted in the loss of the safest and most committed portion of the blood donor population in many Western countries, leading to an increased risk to

  10. High Blood Pressure

    MedlinePlus

    Blood pressure is the force of your blood pushing against the walls of your arteries. Each time your heart ... it pumps blood into the arteries. Your blood pressure is highest when your heart beats, pumping the ...

  11. Protein S blood test

    MedlinePlus

    ... a normal substance in your body that prevents blood clotting. A blood test can be done to see ... family history of blood clots. Protein S helps control blood clotting. A lack of this protein or problem with ...

  12. Protein C blood test

    MedlinePlus

    ... a normal substance in the body that prevents blood clotting. A blood test can be done to see ... history of blood clots. Protein C helps control blood clotting. A lack of this protein or problem with ...

  13. High blood pressure medicines

    MedlinePlus

    Hypertension - medicines ... blood vessel diseases. You may need to take medicines to lower your blood pressure if lifestyle changes ... blood pressure to the target level. WHEN ARE MEDICINES FOR HIGH BLOOD PRESSURE USED Most of the ...

  14. Low Blood Pressure

    MedlinePlus

    ... High Blood Pressure Tools & Resources Stroke More Low Blood Pressure Updated:Aug 30,2016 To know if you ... to learn more about blood pressure . If my blood pressure stays around 85/55, do I have a ...

  15. Blood Donation Process

    MedlinePlus

    ... Blood Donation Information > Blood Donation Process Blood Donation Process Page Content Donating blood is a safe, simple, ... this test, as well as during the donation process, is sterile, used only once and then disposed. ...

  16. Blood Transfusion and Donation

    MedlinePlus

    ... in the United States receive life-saving blood transfusions. During a transfusion, you receive whole blood or parts of blood ... liver failure or a severe infection. Most blood transfusions go very smoothly. Some infectious agents, such as ...

  17. White Blood Cell Count

    MedlinePlus

    ... Home Visit Global Sites Search Help? White Blood Cell Count Share this page: Was this page helpful? Also ... Leukocyte Count; White Count Formal name: White Blood Cell Count Related tests: Complete Blood Count , Blood Smear , White ...

  18. Understanding Blood Pressure Readings

    MedlinePlus

    ... Pressure Tools & Resources Stroke More Understanding Blood Pressure Readings Updated:Aug 17,2016 Blood pressure is typically ... Your doctor should evaluate unusually low blood pressure readings. How is high blood pressure diagnosed? Your healthcare ...

  19. Yeasts in spa establishments.

    PubMed

    Svorcová, L

    1982-05-01

    It was investigated occurrence of yeasts on bathsurfaces, in sauna rooms, in swimming and therapeutic pool water. The number of yeasts decreased depending on patients age, if the rooms were furnished with bath. The lowest contamination was found after bath of 40-60 years-old women. In the saunas were yeasts not found on the upper benches with temperature above 55 degrees C. Much higher counts on lower benches and wood mats with temperature 35-40 degrees C, on basin walls and bottom-up to 10(4)-10(6)/100 cm2. It was isolated 172 yeast strains. The occurrence of some selected strains is given in Table 7, with the toxic effect of disinfectants. The most strains were resistant to Peracetic acid and Chloramin B. Since most of the isolated and determinated strains were found in contaminated environment or during various diseases, the yeasts of the genus Cryptococcus, Candida, Rhodotorula, Torulopsis and Metschnikowia should not occur in bath establishment, and should be classified among indicators of contamination of environment including water. PMID:7124167

  20. Red blood cell morphology.

    PubMed

    Ford, J

    2013-06-01

    The foundation of laboratory hematologic diagnosis is the complete blood count and review of the peripheral smear. In patients with anemia, the peripheral smear permits interpretation of diagnostically significant red blood cell (RBC) findings. These include assessment of RBC shape, size, color, inclusions, and arrangement. Abnormalities of RBC shape and other RBC features can provide key information in establishing a differential diagnosis. In patients with microcytic anemia, RBC morphology can increase or decrease the diagnostic likelihood of thalassemia. In normocytic anemias, morphology can assist in differentiating among blood loss, marrow failure, and hemolysis-and in hemolysis, RBC findings can suggest specific etiologies. In macrocytic anemias, RBC morphology can help guide the diagnostic considerations to either megaloblastic or nonmegaloblastic causes. Like all laboratory tests, RBC morphologies must be interpreted with caution, particularly in infants and children. When used properly, RBC morphology can be a key tool for laboratory hematology professionals to recommend appropriate clinical and laboratory follow-up and to select the best tests for definitive diagnosis. PMID:23480230

  1. Red blood cell morphology.

    PubMed

    Ford, J

    2013-06-01

    The foundation of laboratory hematologic diagnosis is the complete blood count and review of the peripheral smear. In patients with anemia, the peripheral smear permits interpretation of diagnostically significant red blood cell (RBC) findings. These include assessment of RBC shape, size, color, inclusions, and arrangement. Abnormalities of RBC shape and other RBC features can provide key information in establishing a differential diagnosis. In patients with microcytic anemia, RBC morphology can increase or decrease the diagnostic likelihood of thalassemia. In normocytic anemias, morphology can assist in differentiating among blood loss, marrow failure, and hemolysis-and in hemolysis, RBC findings can suggest specific etiologies. In macrocytic anemias, RBC morphology can help guide the diagnostic considerations to either megaloblastic or nonmegaloblastic causes. Like all laboratory tests, RBC morphologies must be interpreted with caution, particularly in infants and children. When used properly, RBC morphology can be a key tool for laboratory hematology professionals to recommend appropriate clinical and laboratory follow-up and to select the best tests for definitive diagnosis.

  2. INDUSTRIAL ASSESSMENT CENTER PROGRAM

    SciTech Connect

    ASFAW BEYENE

    2008-09-29

    Since its establishment in 1990, San Diego State University’s Industrial Assessment Center (IAC) has served close to 400 small and medium-sized manufacturing plants in Southern California. SDSU/IAC’s efforts to transfer state-of-the-art technologies to industry have increased revenues, cultivated creativity, improved efficiencies, and benefited the environment. A substantial benefit from the program has been the ongoing training of engineering faculty and students. During this funding cycle, SDSU/IAC has trained 31 students, 7 of the graduate. A total of 92 assessments and 108 assessment days were completed, resulting in 638 assessment recommendations.

  3. Industrial Robots.

    ERIC Educational Resources Information Center

    Reed, Dean; Harden, Thomas K.

    Robots are mechanical devices that can be programmed to perform some task of manipulation or locomotion under automatic control. This paper discusses: (1) early developments of the robotics industry in the United States; (2) the present structure of the industry; (3) noneconomic factors related to the use of robots; (4) labor considerations…

  4. Industrial Minerals.

    ERIC Educational Resources Information Center

    Brady, Lawrence L.

    1983-01-01

    Discusses trends in and factors related to the production of industrial minerals during 1982, indicating that, as 1981 marked a downturn in production of industrial minerals, 1982 continued the trend with temporary and permanent cutbacks in mine and plant production. Includes highlights of several conferences/conference papers in this field.…

  5. What Is Blood?

    MedlinePlus

    ... 9% A+ 31% A- 6% B+ 9% B- 2% AB+ 3% AB- 1% Blood Group Compatibility There are very specific ways in which blood types must be matched for a safe transfusion. Rollover blood group to view compatibility. RED BLOOD CELLS WHOLE BLOOD PLASMA Donor O Group O can donate red blood ...

  6. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2000-01-01

    The state of the global industrial garnet industry in 1999 is discussed. Industrial garnet mined in the U.S., which accounts for approximately one-third of the world's total, is usually a solid-solution of almandine and pyrope. The U.S. is the largest consumer of industrial garnet, using an estimated 47,800 st in 1999 as an abrasive and as a filtration medium in the petroleum industry, filtration plants, aircraft and motor vehicle manufacture, shipbuilding, wood furniture finishing operations, electronic component manufacture, ceramics manufacture, and glass production. Prices for crude concentrates ranged from approximately $50 to $110/st and refined garnet from $50 to $215/st in 1999, depending on type, source, quantity purchased, quality, and application.

  7. Industrial lead poisoning in China over the past 33 years.

    PubMed

    Wang, Y L

    1984-12-01

    This paper is a review of the 48 articles in scientific journals and special reports of investigations emanating from the author's department involving 2504 subjects. During the past 33 years, as a result of the establishment of health and antiepidemic stations throughout the country, the enactment of hygienic standards, and the setting up of the reporting system for industrial poisoning and occupational diseases, the air lead level has been reduced from 10 mg/m3 in the years soon after liberation (1949) to below 0.03 mg/m3 at present. Severe plumbism has disappeared. Some mild cases, however, could still be found among workers in lead smelters and electric battery plants. Great advances have been made in techniques for early diagnosis of lead poisoning. Blood lead, urine lead, aminolevulinic dehydrase, free erythrocyte protoporphyrin, and zinc protoporphyrin (ZnPP) have been used as criteria for lead exposure. For the purpose of preventive monitoring, ZnPP as a screening index is the first choice. Behavioral function and sensory and motor nerve conduction velocity measurements of median nerve might also be used for the investigation of lead exposure. The maximum allowable concentration of 0.03 mg/m3 for air lead level in the workshop, in agreement with the results of a nationwide lead industry investigation, has been proven safe. There is also the need to monitor the air lead level and blood lead level in the general population and children living adjacent to a lead industry. PMID:6391901

  8. How to establish and sustain a joint venture in China.

    PubMed

    Lee, Paul

    2008-01-01

    Joint ventures with Chinese companies provide one of the most effective ways for international companies to establish a foothold in the booming Chinese economy. The benefits, opportunities and challenges of establishing a joint venture are explored here. Current partnering trends and successful Sino-foreign joint ventures in the fast-growing medical device industry in China are also highlighted. PMID:18605293

  9. 7 CFR 1951.133 - Establishment of Federal Debt.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Establishment of Federal Debt. 1951.133 Section 1951... Agency Borrowers § 1951.133 Establishment of Federal Debt. Any amounts paid by RBS on account of liabilities of a business and industry (B&I) program guaranteed loan borrower will constitute a Federal...

  10. 7 CFR 1951.133 - Establishment of Federal Debt.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Establishment of Federal Debt. 1951.133 Section 1951... Agency Borrowers § 1951.133 Establishment of Federal Debt. Any amounts paid by RBS on account of liabilities of a business and industry (B&I) program guaranteed loan borrower will constitute a Federal...

  11. How to establish and sustain a joint venture in China.

    PubMed

    Lee, Paul

    2008-01-01

    Joint ventures with Chinese companies provide one of the most effective ways for international companies to establish a foothold in the booming Chinese economy. The benefits, opportunities and challenges of establishing a joint venture are explored here. Current partnering trends and successful Sino-foreign joint ventures in the fast-growing medical device industry in China are also highlighted.

  12. Fluorescence switch on-off-on receptor constructed of quinoline allied calix[4]arene for selective recognition of Cu2+ from blood serum and F- from industrial waste water.

    PubMed

    Sutariya, Pinkesh G; Pandya, Alok; Lodha, Anand; Menon, Shobhana K

    2013-05-01

    A novel PET with ICT based substituted calix[4]arene fluroionophore was synthesized and used for detection of Cu(2+) and F(-) by emission spectra. The detection limit of the synthesized receptor was found to be 4.16 nM for Cu(2+) and 2.15 nM for F(-). Moreover, this probe has been applied for recognition of Cu(2+) in blood serum and F(-) from waste water.

  13. Red blood cell damage by shear stress for different blood types

    NASA Astrophysics Data System (ADS)

    Arwatz, Gilad; Bedkowski, Katherine; Smits, Alexander

    2011-11-01

    In surgical practice, blood damage caused by medical devices is often a limiting factor in the duration of an acute procedure or in chronic exposures such as hemodialysis. In order to establish guidelines for designing medical devices, a study was conducted to determine the relationship between shear stress and damage to red blood cells using a concentric Couette device. By measuring the hemolysis level for various shear stresses and exposure times, a non-dimensional relationship between shear stress and blood damage for different blood types was established. Funding provided by Princeton University's Project X.

  14. 21 CFR 606.171 - Reporting of product deviations by licensed manufacturers, unlicensed registered blood...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... manufacturers, unlicensed registered blood establishments, and transfusion services. 606.171 Section 606.171...) BIOLOGICS CURRENT GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Records and Reports § 606.171 Reporting of product deviations by licensed manufacturers, unlicensed registered blood establishments,...

  15. 21 CFR 606.171 - Reporting of product deviations by licensed manufacturers, unlicensed registered blood...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... manufacturers, unlicensed registered blood establishments, and transfusion services. 606.171 Section 606.171...) BIOLOGICS CURRENT GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Records and Reports § 606.171 Reporting of product deviations by licensed manufacturers, unlicensed registered blood establishments,...

  16. 21 CFR 606.171 - Reporting of product deviations by licensed manufacturers, unlicensed registered blood...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... manufacturers, unlicensed registered blood establishments, and transfusion services. 606.171 Section 606.171...) BIOLOGICS CURRENT GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Records and Reports § 606.171 Reporting of product deviations by licensed manufacturers, unlicensed registered blood establishments,...

  17. 21 CFR 606.171 - Reporting of product deviations by licensed manufacturers, unlicensed registered blood...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... manufacturers, unlicensed registered blood establishments, and transfusion services. 606.171 Section 606.171...) BIOLOGICS CURRENT GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Records and Reports § 606.171 Reporting of product deviations by licensed manufacturers, unlicensed registered blood establishments,...

  18. 21 CFR 606.171 - Reporting of product deviations by licensed manufacturers, unlicensed registered blood...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... manufacturers, unlicensed registered blood establishments, and transfusion services. 606.171 Section 606.171...) BIOLOGICS CURRENT GOOD MANUFACTURING PRACTICE FOR BLOOD AND BLOOD COMPONENTS Records and Reports § 606.171 Reporting of product deviations by licensed manufacturers, unlicensed registered blood establishments,...

  19. Industrial Lubricants

    NASA Astrophysics Data System (ADS)

    Kajdas, C.; Karpińska, A.; Kulczycki, A.

    'Industrial lubricant' gaseous, liquid and solid products cover many applications. A new systems analysis approach is used combining heterogeneous catalysis and tribochemistry. Bearing lubricant applications are discussed in terms of the bearing film thickness and tribological regimes, for liquid and solid lubricants. Compressor and vacuum pump lubricant applications are described. The various classes of hydraulic fluids for industrial applications are explained. The properties, applications and selection of various industrial lubricants for different gears are described. Steam and industrial gas turbine lubricant formulations are discussed and the effects of their degradation products, particularly for valves and filters, are presented. Metalworking lubricant applications are divided into cutting and forming operations and their actions are described. Speciality applications such as process, textile, food-grade, slideway, cylinder and wire rope lubricants are explained.

  20. Fermentation industry

    SciTech Connect

    Irvine, R.L.

    1980-06-01

    This article reviews current literature on the fermentation industry. The reuse, recycling and recovery of by-products previously discarded as waste are mentioned, including a Swedish brewery that hopes to reduce discharge of pollutants and the production of single cell protein from a variety of fermentation wastes. The treatment of wastes to produce food substitutes and fertilizers is mentioned together with treatment methods used in distilleries, wineries and in the pharmaceutical industry. (87 References)

  1. Measurement and interpretation of arterial blood gases.

    PubMed

    Syabbalo, N

    1997-01-01

    Arterial blood gases and pH are routinely being measured in clinical practice, both to provide diagnosis and to guide therapy in critically ill patients. Oximetry is clinically useful in establishing the presence of hypoxaemia in patients with respiratory diseases. Oximetry is also a simple and reliable method for monitoring patients undergoing anaesthesia, sleep studies and cardiopulmonary exercise testing. The search continues for new innovative techniques for continuous transcutaneous and intra-arterial blood gas monitoring. This is essential in the management of critically ill patients because blood analysers provide only intermittent monitoring of arterial blood gases. PMID:9293061

  2. 21 CFR 864.9160 - Blood group substances of nonhuman origin for in vitro diagnostic use.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Blood group substances of nonhuman origin for in... Used In Establishments That Manufacture Blood and Blood Products § 864.9160 Blood group substances of nonhuman origin for in vitro diagnostic use. (a) Identification. Blood group substances of nonhuman...

  3. 21 CFR 864.9160 - Blood group substances of nonhuman origin for in vitro diagnostic use.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Blood group substances of nonhuman origin for in... Used In Establishments That Manufacture Blood and Blood Products § 864.9160 Blood group substances of nonhuman origin for in vitro diagnostic use. (a) Identification. Blood group substances of nonhuman...

  4. 21 CFR 864.9160 - Blood group substances of nonhuman origin for in vitro diagnostic use.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Blood group substances of nonhuman origin for in... Used In Establishments That Manufacture Blood and Blood Products § 864.9160 Blood group substances of nonhuman origin for in vitro diagnostic use. (a) Identification. Blood group substances of nonhuman...

  5. 21 CFR 864.9160 - Blood group substances of nonhuman origin for in vitro diagnostic use.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Blood group substances of nonhuman origin for in... Used In Establishments That Manufacture Blood and Blood Products § 864.9160 Blood group substances of nonhuman origin for in vitro diagnostic use. (a) Identification. Blood group substances of nonhuman...

  6. High Blood Pressure

    MedlinePlus

    ... version of this page please turn Javascript on. High Blood Pressure What Is High Blood Pressure? High blood pressure is a common disease in ... the heart, kidneys, brain, and eyes. Types of High Blood Pressure There are two main types of high blood ...

  7. Court upholds blood bank in dispute over expert proof.

    PubMed

    1998-10-16

    A Colorado appeals court upheld summary judgment for a blood bank that was sued by a transfusion recipient who contracted HIV. [Name removed] presented no admissible proof that she would have escaped HIV infection if the Belle Bonfils Memorial Blood Center had used a method that required freezing and retesting the blood. [Name removed] provided an expert witness, but the witness's testimony failed to explain how the process could be used in blood banks nationally without crippling the industry. The court found that it would be impractical for a blood bank to freeze and retest all blood products.

  8. Can industry`s `fourth` fossil fuel establish presence in US?

    SciTech Connect

    Armor, A.F.; Dene, C.E.

    1996-09-01

    After five years of commercial experience burning Orimulsion overseas, US utilities are now evaluating the new fuel as a serious alternative to oil. In their relentless drive to remain competitive, electric utilities with oil-fired generating units are searching for lower cost fuel alternatives. Because of high fuel prices, oil-fired units have low capacity factors. Only 23 out of 142 oil-capable units in the US had capacity factors greater than 50% in 1993; the average was a mere 24%. Utility consumption of fuel oil slid from over 600,000 barrels (bbl)/day in 1989 to less than 200,000 bbl/day last year. Orimulsion now fuels nearly 3,000 MW/yr worldwide. The UK`s PowerGen Ltd, currently the world`s largest consumer of Orimulsion, fires some 10-million bbl/yr at two 500-MW units at its Ince plant and three 120-MW units at its Richborough plant. Both plants formerly burned fuel oil, and have been using Orimulsion since 1991. Canada`s New Brunswick Power Corp has fired Orimulsion in two units at its Dalhousie plant since 1994 (Power, April 1995, p 27); one 105-MW unit was originally designed for fuel oil, the other 212-MW unit was designed for coal. Last year, Denmark`s SK Power converted its coal-fired, 700-MW Asnaes Unit 5 to Orimulsion firing. And in the US, Florida Power and Light Co. (FP and L) has signed a 20-yr fuel supply contract with Bitor America Corp (Boca Raton, Fla.), for two 800-MW units at the oil-fired Manatee plant, contingent on securing necessary permits. The Manatee installation (Power, September 1994, p 57) would be the first in the US to burn the fuel. Today, five years after Orimulsion begun to be used commercially, many of the lingering questions involving the new fuel`s handling, transportation, combustion, emissions control, spill control, and waste utilization have been settled. Several US utilities have expressed serious interest in the fuel as an alternative to oil.

  9. Iatrogenic blood-borne viral infections in refugee children from war and transition zones.

    PubMed

    Goldwater, Paul N

    2013-06-01

    Pediatric infectious disease clinicians in industrialized countries may encounter iatrogenically transmitted HIV, hepatitis B virus, and hepatitis C virus infections in refugee children from Central Asia, Southeast Asia, and sub-Saharan Africa. The consequences of political collapse and/or civil war-work migration, prostitution, intravenous drug use, defective public health resources, and poor access to good medical care-all contribute to the spread of blood-borne viruses. Inadequate infection control practices by medical establishments can lead to iatrogenic infection of children. Summaries of 4 cases in refugee children in Australia are a salient reminder of this problem.

  10. Asynchronicity of facial blood perfusion in migraine.

    PubMed

    Zaproudina, Nina; Teplov, Victor; Nippolainen, Ervin; Lipponen, Jukka A; Kamshilin, Alexei A; Närhi, Matti; Karjalainen, Pasi A; Giniatullin, Rashid

    2013-01-01

    Asymmetrical changes in blood perfusion and asynchronous blood supply to head tissues likely contribute to migraine pathophysiology. Imaging was widely used in order to understand hemodynamic variations in migraine. However, mapping of blood pulsations in the face of migraineurs has not been performed so far. We used the Blood Pulsation Imaging (BPI) technique, which was recently developed in our group, to establish whether 2D-imaging of blood pulsations parameters can reveal new biomarkers of migraine. BPI characteristics were measured in migraineurs during the attack-free interval and compared to healthy subjects with and without a family history of migraine. We found a novel phenomenon of transverse waves of facial blood perfusion in migraineurs in contrast to healthy subjects who showed synchronous blood delivery to both sides of the face. Moreover, the amplitude of blood pulsations was symmetrically distributed over the face of healthy subjects, but asymmetrically in migraineurs and subjects with a family history of migraine. In the migraine patients we found a remarkable correlation between the side of unilateral headache and the direction of the blood perfusion wave. Our data suggest that migraine is associated with lateralization of blood perfusion and asynchronous blood pulsations in the facial area, which could be due to essential dysfunction of the autonomic vascular control in the face. These findings may further enhance our understanding of migraine pathophysiology and suggest new easily available biomarkers of this pathology. PMID:24324592

  11. Blood vessels, circulation and blood pressure.

    PubMed

    Hendry, Charles; Farley, Alistair; McLafferty, Ella

    This article, which forms part of the life sciences series, describes the vessels of the body's blood and lymphatic circulatory systems. Blood pressure and its regulatory systems are examined. The causes and management of hypertension are also explored. It is important that nurses and other healthcare professionals understand the various mechanisms involved in the regulation of blood pressure to prevent high blood pressure or ameliorate its damaging consequences.

  12. [Blood transfusion and supply chain management safety].

    PubMed

    Quaranta, Jean-François; Caldani, Cyril; Cabaud, Jean-Jacques; Chavarin, Patricia; Rochette-Eribon, Sandrine

    2015-02-01

    The level of safety attained in blood transfusion now makes this a discipline better managed care activities. This was achieved both by scientific advances and policy decisions regulating and supervising the activity, as well as by the quality system, which we recall that affects the entire organizational structure, responsibilities, procedures, processes and resources in place to achieve quality management. So, an effective quality system provides a framework within which activities are established, performed in a quality-focused way and continuously monitored to improve outcomes. This system quality has to irrigate all the actors of the transfusion, just as much the establishments of blood transfusion than the health establishments. PMID:25578550

  13. [Blood transfusion and supply chain management safety].

    PubMed

    Quaranta, Jean-François; Caldani, Cyril; Cabaud, Jean-Jacques; Chavarin, Patricia; Rochette-Eribon, Sandrine

    2015-02-01

    The level of safety attained in blood transfusion now makes this a discipline better managed care activities. This was achieved both by scientific advances and policy decisions regulating and supervising the activity, as well as by the quality system, which we recall that affects the entire organizational structure, responsibilities, procedures, processes and resources in place to achieve quality management. So, an effective quality system provides a framework within which activities are established, performed in a quality-focused way and continuously monitored to improve outcomes. This system quality has to irrigate all the actors of the transfusion, just as much the establishments of blood transfusion than the health establishments.

  14. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2013-01-01

    Estimated 2012 world production of natural and synthetic industrial diamond was about 4.45 billion carats. During 2012, natural industrial diamonds were produced in at least 20 countries, and synthetic industrial diamond was produced in at least 12 countries. About 99 percent of the combined natural and synthetic global output was produced in Belarus, China, Ireland, Japan, Russia, South Africa and the United States. During 2012, China was the world’s leading producer of synthetic industrial diamond followed by the United States and Russia. In 2012, the two U.S. synthetic producers, one in Pennsylvania and the other in Ohio, had an estimated output of 103 million carats, valued at about $70.6 million. This was an estimated 43.7 million carats of synthetic diamond bort, grit, and dust and powder with a value of $14.5 million combined with an estimated 59.7 million carats of synthetic diamond stone with a value of $56.1 million. Also in 2012, nine U.S. firms manufactured polycrystalline diamond (PCD) from synthetic diamond grit and powder. The United States government does not collect or maintain data for either domestic PCD producers or domestic chemical vapor deposition (CVD) diamond producers for quantity or value of annual production. Current trade and consumption quantity data are not available for PCD or for CVD diamond. For these reasons, PCD and CVD diamond are not included in the industrial diamond quantitative data reported here.

  15. 77 FR 25721 - Small Entity Compliance Guide: Bottled Water: Quality Standard: Establishing an Allowable Level...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... HUMAN SERVICES Food and Drug Administration Small Entity Compliance Guide: Bottled Water: Quality... availability of a guidance for industry entitled ``Bottled Water: Quality Standard: Establishing an Allowable... its bottled water standard of quality regulations by establishing an allowable level for...

  16. Blood Donation by Elderly Repeat Blood Donors

    PubMed Central

    Zeiler, Thomas; Lander-Kox, Jutta; Alt, Timo

    2014-01-01

    Summary Background Upper age limits for blood donors are intended to protect elderly blood donors from donor reactions. However, due to a lack of data about adverse reactions in elderly blood donors, upper age limits are arbitrary and vary considerably between different countries. Methods Here we present data from 171,231 voluntary repeat whole blood donors beyond the age of 68 years. Results Blood donations from repeat blood donors beyond the age of 68 years increased from 2,114 in 2005 to 38,432 in 2012 (from 0,2% to 4.2% of all whole blood donations). Adverse donor reactions in repeat donors decreased with age and were lower than in the whole group (0.26%), even in donors older than 71 years (0.16%). However, from the age of 68 years, the time to complete recovery after donor reactions increased. Donor deferrals were highest in young blood donors (21.4%), but increased again in elderly blood donors beyond 71 years (12.6%). Conclusion Blood donation by regular repeat blood donors older than 71 years may be safely continued. However, due to a lack of data for donors older than 75 years, blood donation in these donors should be handled with great caution. PMID:25254019

  17. Low Blood Pressure

    MedlinePlus

    ... the walls of your arteries. Each time your heart beats, it pumps out blood into the arteries. Your blood pressure is highest when your heart beats, pumping the blood. This is called systolic pressure. ...

  18. Coughing up blood

    MedlinePlus

    ... gastrointestinal tract. Blood that comes up with a cough often looks bubbly because it is mixed with ... conditions, diseases, and medical tests may make you cough up blood. These include: Blood clot in the ...

  19. Low Blood Glucose (Hypoglycemia)

    MedlinePlus

    ... Other Dental Problems Diabetic Eye Disease Low Blood Glucose (Hypoglycemia) What is hypoglycemia? Hypoglycemia, also called low ... actions can also help prevent hypoglycemia: Check blood glucose levels Knowing your blood glucose level can help ...

  20. Ketones blood test

    MedlinePlus

    ... Ketones - serum; Nitroprusside test; Ketone bodies - serum; Ketones - blood ... A blood sample is needed. ... When the needle is inserted to draw blood, some people feel slight ... there may be some throbbing or a slight bruise. This soon ...

  1. Magnesium blood test

    MedlinePlus

    Magnesium - blood ... A blood sample is needed. ... When the needle is inserted to draw blood, some people feel slight pain. Others feel a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon ...

  2. CEA blood test

    MedlinePlus

    Carcinoembryonic antigen blood test ... A blood sample is needed . ... When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing or a slight bruise. ...

  3. Postpartum Blood Clots

    MedlinePlus

    ... Breast Infection Postpartum Blood Clots Postpartum Thyroid Disorders Postpartum Depression The risk of developing blood clots (thrombophlebitis) is ... Breast Infection Postpartum Blood Clots Postpartum Thyroid Disorders Postpartum Depression NOTE: This is the Consumer Version. CONSUMERS: Click ...

  4. Blood Test: Testosterone

    MedlinePlus

    ... secretes two hormones (luteinizing hormone, or LH; and follicle-stimulating hormone, or FSH) that work together to ... TOPIC Blood Test: Luteinizing Hormone (LH) Blood Test: Follicle Stimulating Hormone (FSH) Blood Test: Estradiol Precocious Puberty ...

  5. Blood Frequently Asked Questions

    MedlinePlus

    ... manufacturers commonly produce these blood products. Top What fees are associated with blood? While donated blood is ... donors; and quality assurance. As a result, processing fees are charged to recover costs. Processing fees for ...

  6. High Blood Pressure (Hypertension)

    MedlinePlus

    ... Print Page Text Size: A A A Listen High Blood Pressure (Hypertension) Nearly 1 in 3 American adults has high ... weight. How Will I Know if I Have High Blood Pressure? High blood pressure is a silent problem — you ...

  7. Blood Type Puzzle.

    ERIC Educational Resources Information Center

    Kelly, Janet

    1997-01-01

    Presents a blood type puzzle that provides a visual, hands-on mechanism by which students can examine blood group reactions. Offers students an opportunity to construct their own knowledge about blood types. (JRH)

  8. Research Projects in Industrial Technology.

    SciTech Connect

    United States. Bonneville Power Administration. Industrial Technology Section.

    1990-06-01

    The purpose of this booklet is to briefly describe ongoing and completed projects being carried out by Bonneville Power Administration's (BPA) Industrial Technology Section. In the Pacific Northwest, the industrial sector is the largest of the four consuming sectors. It accounted for thirty-nine percent of the total firm demand in the region in 1987. It is not easy to asses the conservation potential in the industrial sector. Recognizing this, the Northwest Power Planning Council established an objective to gain information on the size, cost, and availability of the conservation resource in the industrial sector, as well as other sectors, in its 1986 Power Plan. Specifically, the Council recommended that BPA operate a research and development program in conjunction with industry to determine the potential costs and savings from efficiency improvements in industrial processes which apply to a wide array of industrial firms.'' The section, composed of multidisciplinary engineers, provides technical support to the Industrial Programs Branch by designing and carrying out research relating to energy conservation in the industrial sector. The projects contained in this booklet are arranged by sector --industrial, utility, and agricultural -- and, within each sector, chronologically from ongoing to completed, with those projects completed most recently falling first. For each project the following information is given: its objective approach, key findings, cost, and contact person. Completed projects also include the date of completion, a report title, and report number.

  9. Blood stain pattern analysis.

    PubMed

    Peschel, O; Kunz, S N; Rothschild, M A; Mützel, E

    2011-09-01

    Bloodstain pattern analysis (BPA) refers to the collection, categorization and interpretation of the shape and distribution of bloodstains connected with a crime. These kinds of stains occur in a considerable proportion of homicide cases. They offer extensive information and are an important part of a functional, medically and scientifically based reconstruction of a crime. The following groups of patterns can essentially be distinguished: dripped and splashed blood, projected blood, impact patterns, cast-off stains, expirated and transferred bloodstains. A highly qualified analysis can help to estimate facts concerning the location, quality and intensity of an external force. A sequence of events may be recognized, and detailed questions connected with the reconstruction of the crime might be answered. In some cases, BPA helps to distinguish between accident, homicide and suicide or to identify bloodstains originating from a perpetrator. BPA is based on systematic training, a visit to the crime scene or alternatively good photographic documentation, and an understanding and knowledge of autopsy findings or statements made by the perpetrator and/or victim. A BPA working group has been established within the German Society of Legal Medicine aiming to put the knowledge and practical applications of this subdiscipline of forensic science on a wider basis. PMID:21069481

  10. Atomic Weapons Establishment, Aldermaston UK site overview

    SciTech Connect

    Elliott, R.A.

    1990-11-01

    The UK Nuclear Weapons Industry has at its core the Atomic Weapons Establishments at Aldermaston, Burghfield, Cardiff and Foulness all of which are part of the Ministry of Defense (MOD). The paper illustrates the upper echelons of the MOD and shows the structure within Aldermaston. The Superintendent Quality Management has three sections: Inspection, Quality Assurance and Development, the latter of which contains the Robotics Section. The locations of the establishments are shown. Remote handling and automation of production procedures distance the operator from hazardous materials in the following areas: (1) The glovebox environment where radioactive and hygroscopic materials are machined and measured; (2) The remote cell environment for machining and assembly of explosive and radioactive materials; and (3) decommissioning activities in the waste management group at Aldermaston. The robotics section provides an advisory service to all sites but may also be tasked internally by other sections within the Superintendency.

  11. Blood transfusion and coagulation management.

    PubMed

    Meier, Jens

    2016-09-01

    Despite impressive progress in surgical technique, aortic surgery is still associated with relatively high morbidity and mortality. One of the most important contributors to this phenomenon is the triad of bleeding, anemia, and transfusion. All three factors are known to influence the outcome of aortic surgery to a great extent. However, over the last few years a multidisciplinary, multimodal concept has been established, which enables the physician to avoid bleeding, anemia, and transfusion as much as possible. The concept of "patient blood management" combines several established measures with the potential to improve perioperative outcome. This chapter describes these measures with regard to aortic surgery and assesses their respective efficacy. PMID:27650346

  12. Industrial diamond

    USGS Publications Warehouse

    Olson, D.W.

    2007-01-01

    World production of natural and synthetic industrial diamond was about 648 million carats in 2006, with 79 percent of the production coming from Ireland, Japan, Russia, South Africa, and the U.S. U.S. consumption was was an estimated 602 million carats, imports were over 391 million carats, and exports were about 83 million carats. About 87 percent of the industrial diamonds market uses synthetic diamonds, which are expected to become less expensive as technology improves and competition from low-cost producers increases.

  13. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2006-01-01

    In 2005, US production of crude garnet concentrate for industrial use was 28.4 kt valued at $3.05 million. Refined garnet material sold or used was 30.4 kt valued at $10 million. For the year, the US was one of the world's leading consumers of industrial garnet. Domestic values for crude concentrates for different applications ranged from about $53 to $120/t. In the short term, excess production capacity, combined with suppliers that vary in quality, grain size and mineral type, will keep prices down.

  14. Blood Test: Estradiol

    MedlinePlus

    ... Testosterone Blood Test: Luteinizing Hormone (LH) Blood Test: Follicle Stimulating Hormone (FSH) Understanding Early Sexual Development Precocious Puberty Understanding Puberty Endocrine System Getting a ...

  15. Surveys in industrial wastewater treatment, Vol. 3: Manufacturing and chemical industries

    SciTech Connect

    Barnes, D.

    1987-01-01

    The author presents a detailed review of the treatment of wastewaters from groups of industries. Individual reviews are written by experts and reflect established or proven practice. This third volume, which deals with inorganic waste waters, covers plating, silver recovery (particularly from the photographic industry), general inorganic chemical industries, chloro-alkalai (particularly the treatment and disposal of mercury sludges), and the steel industry. The second volume discusses organic-based waste waters, with chapters on the dyestuffs, petrochemicals, oil refining, and synthetic fuels industries. The first volume is concerned with the food and beverage industries, with chapters on sugar, dairy, beverage, fruit and vegetable, and meat and poultry industry wastes.

  16. Industrial Microorganisms.

    ERIC Educational Resources Information Center

    Phaff, Herman J.

    1981-01-01

    Describes industrially important yeasts, molds, bacteria, and actinomycetes. Discussed in detail are microbial products, such as primary metabolites, secondary metabolites, enzymes, and capsular polysaccharides. Traces the historical background of human cell culture, mentioning recombinant DNA research and hybridization of normal mammalian cells…

  17. Learned Industriousness.

    ERIC Educational Resources Information Center

    Eisenberger, Robert

    1991-01-01

    Individual differences in industriousness are discussed. It is proposed that reinforcement for increased physical or cognitive performance, or the tolerance of aversive stimulation, gives a reward value to the sensation of high effort and reduces effort's aversiveness. Applications for self-control, moral development, and education are described.…

  18. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2010-01-01

    In 2009, U.S. production of crude garnet concentrate for industrial use was estimated to be 56.5 kt (62,300 st), valued at about $8.85 million. This was a 10-percent decrease in quantity compared with 2008 production. Refined garnet material sold or used was 28 kt (31,000 st) valued at $7.96 million.

  19. Fermentation Industry.

    ERIC Educational Resources Information Center

    Grady, C. P. L., Jr.; Grady, J. K.

    1978-01-01

    Presents a literature review of wastes from the fermentation industry, covering publications of 1976-77. This review focuses on: (1) alcoholic beverage production; (2) pharmaceuticals and biochemicals production; and (3) biomass production. A list of 62 references is also presented. (HM)

  20. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2011-01-01

    Garnet has been used as a gemstone since the Bronze Age. However, garnet's angular fractures, relatively high hardness and specific gravity, chemical inertness and nontoxicity make it ideal for many industrial applications. It is also free of crystalline silica and can be recycled.

  1. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2013-01-01

    Garnet has been used as a gemstone since the Bronze Age. However, garnet’s angular fractures, relatively high hardness and specific gravity, chemical inertness and nontoxicity make it ideal for many industrial applications. It is also free of crystalline silica and can be recycled.

  2. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2012-01-01

    Garnet has been used as a gemstone since the Bronze Age. However, garnet's angular fractures, relatively high hardness and specific gravity, chemical inertness, and nontoxicity make it ideal for many industrial applications. It is also free of crystalline silica and can be recycled.

  3. Industrial Orientation.

    ERIC Educational Resources Information Center

    Rasor, Leslie; Brooks, Valerie

    These eight modules for an industrial orientation class were developed by a project to design an interdisciplinary program of basic skills training for disadvantaged students in a Construction Technology Program (see Note). The Drafting module overviews drafting career opportunities, job markets, salaries, educational requirements, and basic…

  4. 76 FR 72950 - Draft Guidance for Industry: Use of Nucleic Acid Tests on Pooled and Individual Samples From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... (HBV) deoxyribonucleic acid (DNA) and recommendations for product testing and disposition, donor...- licensed NAT to screen blood donors for HBV DNA. FDA is also providing these blood establishments...

  5. 9 CFR 332.3 - Requirements for establishments; ineligible establishments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...; ineligible establishments. 332.3 Section 332.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... SHIPMENT OF CARCASSES, PARTS OF CARCASSES, MEAT, AND MEAT FOOD PRODUCTS § 332.3 Requirements for... supervisory and non-supervisory, employed by the establishment on a full-time, part-time, or temporary...

  6. 9 CFR 332.3 - Requirements for establishments; ineligible establishments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...; ineligible establishments. 332.3 Section 332.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... SHIPMENT OF CARCASSES, PARTS OF CARCASSES, MEAT, AND MEAT FOOD PRODUCTS § 332.3 Requirements for... supervisory and non-supervisory, employed by the establishment on a full-time, part-time, or temporary...

  7. 9 CFR 332.3 - Requirements for establishments; ineligible establishments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Requirements for establishments; ineligible establishments. 332.3 Section 332.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS...

  8. [A comparative analysis of occupational risk in industry employees based on concentrations of some elements in teeth and body fluids].

    PubMed

    Poczatek, Michał; Machoy, Zygmunt; Gutowska, Izabela; Chlubek, Dariusz

    2004-01-01

    Work safety and hygiene is a set of basic measures to protect workers from the negative effects of manufacturing processes. So far, numerous procedures for assessment of occupational health risk have been described. We measured the concentrations of some elements in teeth and body fluids of employees working in three different industries with an established production profile: Zakłady Naprawcze Taboru Kolejowego (repairs of rail vehicles), Philips Lighting Poland (production of lighting systems) and Metalplast (build ing furbishing factory). Different technologies were in place at each of these plants. Basing on laboratory analyses, the risk of exposure to chemical substances was evaluated. The study material included 100 extracted teeth, as well as body fluid samples (saliva, urine and blood) collected during routine health checks. Whenever possible, concentrations of the following elements were measured: calcium, magnesium, fluorine, phosphorus in the form of phosphates, potassium, sodium, iron, zinc, copper, cadmium, and lead. Metal elements were measured spectrophotometrically (ASA), fluorine with an ion-selective electrode, and phosphates with a colorimetric method. We found that concentrations of the elements in teeth and body fluids differed depending on the industry. For teeth, statistically significant differences applied to magnesium, phosphates, zinc, sodium, and potassium. In body fluids, statistically significant differences were found for calcium (blood and urine), magnesium (blood, urine and saliva), zinc (blood, urine and saliva), iron, lead and copper (urine). In conclusion, our findings may be helpful for monitoring safety at work in industrial plants. PMID:16871749

  9. 75 FR 36060 - Notice of Request for Extension of Approval of an Information Collection; Blood and Tissue...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-24

    ... Collection; Blood and Tissue Collection at Slaughtering and Rendering Establishments AGENCY: Animal and Plant... collection associated with regulations for blood and tissue collection at slaughtering and rendering... FURTHER INFORMATION CONTACT: For information on regulations for blood and tissue collection...

  10. BUN - blood test

    MedlinePlus

    Blood urea nitrogen ... A blood sample is needed. Most of the time blood is drawn from a vein located on the inside ... Many medicines can interfere with blood test results. Your health ... if you need to stop taking any medicines before you have this ...

  11. Types of Blood Donations

    MedlinePlus

    ... laboratory and separated into components (red blood cells, plasma and sometimes into platelets and cryoprecipitate). After processing, the red blood cells can be stored for up to 42 days. Apheresis An apheresis blood donation is one where the blood goes through a special machine ...

  12. High Blood Pressure

    MedlinePlus

    ... page from the NHLBI on Twitter. Description of High Blood Pressure Español High blood pressure is a common disease ... defines high blood pressure severity levels. Stages of High Blood Pressure in Adults Stages Systolic (top number) Diastolic (bottom ...

  13. Industrial garnet

    USGS Publications Warehouse

    Olson, D.W.

    2007-01-01

    World production of industrial garnet was about 326 kt in 2006, with the U.S. producing about 11 percent of this total. U.S. consumption, imports, and exports were estimated at 74.3 kt, 52.3 kt, and 13.2 kt, respectively. The most important exporters are Australia, China, and India. Although demand is expected to rise over the next 5 years, prices are expected to remain low in the short term.

  14. Blood lead levels and chronic blood loss

    SciTech Connect

    Manci, E.A.; Cabaniss, M.L.; Boerth, R.C.; Blackburn, W.R.

    1986-03-01

    Over 90% of lead in blood is bound to the erythrocytes. This high affinity of lead for red cells may mean that chronic blood loss is a significant means for excretion of lead. This study sought correlations between blood lead levels and clinical conditions involving chronic blood loss. During May, June and July, 146 patients with normal hematocrits and red cell indices were identified from the hospital and clinic populations. For each patient, age, race, sex and medical history were noted, and a whole blood sample was analyzed by flameless atomic absorption spectrophotometry. Age-and race-matched pairs showed a significant correlation of chronic blood loss with lead levels. Patients with the longest history of blood loss (menstruating women) had the lowest level (mean 6.13 ..mu..g/dl, range 3.6-10.3 ..mu..g/dl). Post-menopausal women had levels (7.29 ..mu..g/dl, 1.2-14 ..mu..g/dl) comparable to men with peptic ulcer disease, or colon carcinoma (7.31 ..mu..g/dl, 5.3-8.6 ..mu..g/dl). The highest levels were among men who had no history of bleeding problems (12.39 ..mu..g/dl, 2.08-39.35 ..mu..g/dl). Chronic blood loss may be a major factor responsible for sexual differences in blood lead levels. Since tissue deposition of environmental pollutants is implicated in diseases, menstruation may represent a survival advantage for women.

  15. 9 CFR 381.513 - Requirements for establishments; ineligible establishments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... establishment from a temporary employee agency, professional employee organization, or leasing concern whose... SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY..., part-time, or temporary basis whose duties involve handling the poultry products prepared by...

  16. Recent developments: Industry briefs

    SciTech Connect

    1992-04-01

    This article is the `Industry Briefs` portion of Nuexco`s April 1992 `Recent Developments` section. Items covered in this article include: (1) France`s SILVA enrichment process, (2) 1993 US enrichment prices, (3) relicensing plans for Monticello, (4) a reactor incident at Sosnovy Bor 3, (5) Canadian agreements on Uranium mining, (6) China`s ascession to the Nuclear Non-proliferation Treaty, (7) settlement of the lawsuit between Westinghouse and the Philipines, (8) political reforms on South Africa, and (9) establishment of an international agreement on dual-use export control policy.

  17. [Hospital blood bank: information system and immuno-hematology].

    PubMed

    Vaquier, C; Caldani, C

    2010-12-01

    Due to regulations, hospital blood banks have to equip them with a computer-based information system. This system facilitates the management of the blood bank and ensures the safety of the storage, issuing and traceability of the blood and blood components. It permits to create a medical file for each transfused patient, which contains the characteristics of the blood components transfused and the immunohematological status of the patient, received by electronic data interchange from the blood establishment. Thus, from the assistance to the prescription of blood transfusion to the issuing and traceability of the blood components, the computer-based information system is the guarantee of the transfusion security in a hospital blood bank.

  18. [Hospital blood bank: information system and immuno-hematology].

    PubMed

    Vaquier, C; Caldani, C

    2010-12-01

    Due to regulations, hospital blood banks have to equip them with a computer-based information system. This system facilitates the management of the blood bank and ensures the safety of the storage, issuing and traceability of the blood and blood components. It permits to create a medical file for each transfused patient, which contains the characteristics of the blood components transfused and the immunohematological status of the patient, received by electronic data interchange from the blood establishment. Thus, from the assistance to the prescription of blood transfusion to the issuing and traceability of the blood components, the computer-based information system is the guarantee of the transfusion security in a hospital blood bank. PMID:21051266

  19. The Molecular Control of Blood Cell Development

    NASA Astrophysics Data System (ADS)

    Sachs, Leo

    1987-12-01

    The establishment of a cell culture system for the clonal development of blood cells has made it possible to identify the proteins that regulate the growth and differentiation of different blood cell lineages and to discover the molecular basis of normal and abnormal cell development in blood forming tissues. A model system with myeloid blood cells has shown that (i) normal blood cells require different proteins to induce cell multiplication (growth inducers) and cell differentiation (differentiation inducers), (ii) there is a hierarchy of growth inducers as cells become more restricted in their developmental program, and (iii) a cascade of interactions between proteins determines the correct balance between immature and mature cells in normal blood cell development. Gene cloning has shown that there is a family of different genes for these proteins. Normal protein regulators of blood cell development can control the abnormal growth of certain types of leukemic cells and suppress malignancy by incuding differentiation to mature nondividing cells. Chromosome abnormalities that give rise to malignancy in these leukemic cells can be bypassed and their effects nullified by inducing differentiation, which stops cells from multiplying. These blood cell regulatory proteins are active in culture and in the body, and they can be used clinically to correct defects in blood cell development.

  20. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore....

  1. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore....

  2. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore....

  3. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore....

  4. 36 CFR 27.2 - Commercial and industrial activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... INTERIOR CAPE COD NATIONAL SEASHORE; ZONING STANDARDS § 27.2 Commercial and industrial activities. No commercial or industrial districts may be established within the Cape Cod National Seashore....

  5. Blood Pressure vs. Heart Rate

    MedlinePlus

    ... High Blood Pressure Tools & Resources Stroke More Blood Pressure vs. Heart Rate Updated:Aug 30,2016 Blood ... last reviewed on 08/04/2014. High Blood Pressure • Home • About High Blood Pressure (HBP) Introduction What ...

  6. High Blood Pressure in Pregnancy

    MedlinePlus

    ... The Health Information Center High Blood Pressure in Pregnancy What Is High Blood Pressure? Blood pressure is ... Are the Effects of High Blood Pressure in Pregnancy? Although many pregnant women with high blood pressure ...

  7. Industrial concerns

    NASA Astrophysics Data System (ADS)

    2008-04-01

    Physics in industry is worth reporting, but deciding what counts can be a challenge "If a man can make a better mousetrap than his neighbour...the world will make a beaten path to his door." That quotation, which was apparently inspired by a comment that the American essayist Ralph Waldo Emerson made during a lecture in 1871, has long been used to illustrate the power of invention and innovation. While the lowly mousetrap may hardly seem the pinnacle of technology in today's world of iPhones and Blu-ray DVDs, an effective tool to kill mice was certainly a desirable object in Emerson's day (p52).

  8. Blood Component Therapy

    PubMed Central

    Kelton, J. G.

    1984-01-01

    Human blood has been transfused for about 60-70 years. Over this time, the practice of blood transfusion has changed dramatically. One major change is the separation of blood into its various components. As a result, the patient can receive only the blood component in which he is deficient. In this way, the risk of side effects—particularly hepatitis—is lessened. This article briefly reviews the various blood products, the indications for their use, and some associated risks. These products include oxygen-carrying products, plasma products, blood products used to correct hemostatic defects, and immune globulin. PMID:21279096

  9. The quest for quality blood banking program in the new millennium the American way.

    PubMed

    Kim, Dae Un

    2002-08-01

    For an industry to succeed and satisfy its customers, "QUALITY" must be a primary goal. Quality has been central to blood banking from its inception, with the evolution of a Quality Program since the opening of the first blood bank in U.S. at the Cook County Hospital in 1937. Over the ensuing decades, continuous scientific progress in blood preservation, filters, viral and blood group testing, crossmatching, automation, and computerization including bar coding, etc. has contributed to the quality and safety of the blood products and transfusion service. However, with the advent of the AIDS era, an increasingly sensitized and informed public is continuously demanding that the highest level of quality be achieved and maintained in all processes involved in providing all blood products. The Food and Drug Administration (FDA) introduced the concept of a "zero risk blood supply" as the industry goal. Furthermore, the cost containment and resource-constrained environment have changed the complexity of the quality practice. Both regulatory agencies such as the FDA, the Health Care Financing Administration [HCFA, which was recently renamed as the Centers for Medicare and Medicaid Services (CMS) in July, 2001], and the State Department of Health, and accrediting agencies, such as the American Association of Blood Banks (AABB), the College of American Pathologists (CAP), and the Joint Commission on Accreditation of Healthcare Organizations (JCAHO), require blood banks and transfusion services to establish and follow a Quality Control and Quality Assurance Program for their licensing, certification and accreditation. Every laboratory has to comply with the Clinical Laboratory Improvement Amendments of 1988 (CLIA '88) quality requirements being implemented by the CMS. The FDA guidelines assist facilities in compliance with Current Good Manufacturing Practices (cGMP). The AABB's Quality System Essentials (QSE) are based on these specifications and provide additional guidance in

  10. The quest for quality blood banking program in the new millennium the American way.

    PubMed

    Kim, Dae Un

    2002-08-01

    For an industry to succeed and satisfy its customers, "QUALITY" must be a primary goal. Quality has been central to blood banking from its inception, with the evolution of a Quality Program since the opening of the first blood bank in U.S. at the Cook County Hospital in 1937. Over the ensuing decades, continuous scientific progress in blood preservation, filters, viral and blood group testing, crossmatching, automation, and computerization including bar coding, etc. has contributed to the quality and safety of the blood products and transfusion service. However, with the advent of the AIDS era, an increasingly sensitized and informed public is continuously demanding that the highest level of quality be achieved and maintained in all processes involved in providing all blood products. The Food and Drug Administration (FDA) introduced the concept of a "zero risk blood supply" as the industry goal. Furthermore, the cost containment and resource-constrained environment have changed the complexity of the quality practice. Both regulatory agencies such as the FDA, the Health Care Financing Administration [HCFA, which was recently renamed as the Centers for Medicare and Medicaid Services (CMS) in July, 2001], and the State Department of Health, and accrediting agencies, such as the American Association of Blood Banks (AABB), the College of American Pathologists (CAP), and the Joint Commission on Accreditation of Healthcare Organizations (JCAHO), require blood banks and transfusion services to establish and follow a Quality Control and Quality Assurance Program for their licensing, certification and accreditation. Every laboratory has to comply with the Clinical Laboratory Improvement Amendments of 1988 (CLIA '88) quality requirements being implemented by the CMS. The FDA guidelines assist facilities in compliance with Current Good Manufacturing Practices (cGMP). The AABB's Quality System Essentials (QSE) are based on these specifications and provide additional guidance in

  11. A changing time: the International Society for Cellular Therapy embraces its industry members.

    PubMed

    Deans, Robert; Gunter, Kurt C; Allsopp, Timothy; Bonyhadi, Mark; Burger, Scott R; Carpenter, Melissa; Clark, Tara; Cox, Charles S; Driscoll, Dawn; Field, Ed; Huss, Ralf; Lardenoije, René; Lodie, Tracey A; Mason, Chris; Neubiser, Richard; Rasko, John E J; Rowley, Jon; Maziarz, Richard T

    2010-11-01

    The last decade has seen a dramatic rise in the development of new cellular therapeutics in a wide range of indications. There have been acceptable safety profiles reported in early studies using blood-derived and adherent stem cell products, but also an inconsistent efficacy record. Further expansion has been hindered in part by a lack of capital (both private and public) and delayed entry into the cell therapy space by large healthcare and pharmaceutical companies, those members of the industry most reliably able to initiate and maintain advanced-phase clinical trials. With recognition that the International Society for Cellular Therapy (ISCT) is uniquely positioned to serve the global translational regenerative medicine research community as a network hub for scientific standards and policy, the ISCT commissioned the establishment of an Industry Task Force (ITF) to address current and future roles for industry. The objectives of the ITF were to gather information and prioritize efforts for a new Commercialization Committee (CC) and to construct innovative platforms that would foster constructive and synergistic collaborations between industry and ISCT. Recommendations and conclusions of the ITF included that the new CC: (1) foster new relationships with therapeutic and stem cell societies, (2) foster educational workshops and forums to cross-educate and standardize practices, (3) create industry subcommittees to address priority initiatives, with clear benchmarks and global implementation, and (4) establish a framework for a greater industry community within ISCT, opening doors for industry to share the new vision for commercialization of cell therapy, emphasizing the regenerative medicine space. PMID:20942603

  12. Employment Trends; Eating and Beverage Establishments 1958 to 1968, Louisiana.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Employment Security, Baton Rouge

    Employment in eating and beverage establishments has grown tremendously in Louisiana. In 1940, United States Census figures showed that 18,400 were employed in the industry, and by 1969, the number had increased to 31,000. The situation in Louisiana may not be typical of other states because of a sharp increase in catering services to offshore oil…

  13. Using lake dredged material to enhance pasture establishment

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The cow-calf (Bos taurus) industry in subtropical United States and other parts of the world depends almost totally on grazed pastures. Establishment of complete, uniform stand of bahiagrass in a short time period is vital economically. Domestic wastewater sludge or sewage sludge, composted urban pl...

  14. Establishing a Work Experience Program in Building Trades Entrepreneurship.

    ERIC Educational Resources Information Center

    Gilli, Angelo C., Sr.; Gilli, Lynne M.

    A project was undertaken to establish a cooperative work experience program in building trades entrepreneurship. The first phase of the program, which was implemented in Baltimore, Maryland, involved the formation of a task force that included representatives of the school, business, industry, and public sectors. Eventually, two Baltimore…

  15. Blood Pressure Medicines

    MedlinePlus

    High blood pressure, also called hypertension, usually has no symptoms. But it can cause serious problems such as stroke, heart failure, ... failure. If you cannot control your high blood pressure through lifestyle changes such as losing weight and ...

  16. Low blood pressure

    MedlinePlus

    Hypotension; Blood pressure - low; Postprandial hypotension; Orthostatic hypotension; Neurally mediated hypotension; NMH ... Blood pressure varies from one person to another. A drop as little as 20 mmHg, can cause problems for ...

  17. Lyme disease blood test

    MedlinePlus

    ... antibodies in the blood sample using the ELISA test . If the ELISA test is positive, it must be confirmed with another ... were seen in your blood sample. If the ELISA test is negative, usually no other testing is needed. ...

  18. Haptoglobin blood test

    MedlinePlus

    ... liver. It attaches to a certain type of hemoglobin in the blood. How the Test is Performed ... destroyed. When red blood cells die, they release hemoglobin. Haptoglobin attaches to this released hemoglobin, which is ...

  19. Blood and Diversity

    MedlinePlus

    ... type O negative blood, in particular, is the universal type needed for emergency transfusions. Minority and diverse ... levels. “I was deferred from giving blood 10 times or more.” However, in October 2005 Rosalyn’s iron ...

  20. Blood Transfusion (For Parents)

    MedlinePlus

    ... help to clot the blood and control bleeding. Plasma , the pale yellow liquid part of whole blood. ... patients with bleeding problems, transfusions with platelets or plasma can help to control or prevent bleeding complications. ...

  1. Hypertension (High Blood Pressure)

    MedlinePlus

    ... pressure to live. Without it, blood can't flow through our bodies and carry oxygen to our vital organs. But when blood pressure gets too high — a condition called hypertension — it can lead to ...

  2. Blood Donation Process

    MedlinePlus

    ... Home > Donating Blood > Donation Process Printable Version Donation Process View Video Getting Ready for Your Donation The ... worry about. Make a Donation Appointment The Donation Process Step by Step Donating blood is a simple ...

  3. Blood Count Tests

    MedlinePlus

    ... white blood cells (WBC), and platelets. Blood count tests measure the number and types of cells in ... helps doctors check on your overall health. The tests can also help to diagnose diseases and conditions ...

  4. Blood pressure check (image)

    MedlinePlus

    ... more often referred to as a blood pressure cuff. The cuff is wrapped around your upper arm and inflated ... flow of blood in your artery. As the cuff is slowly deflated, your doctor uses a stethoscope ...

  5. Blood Sugar and Fats

    MedlinePlus

    ... a deciliter) of blood, or mg/dL. Measuring Triglycerides Triglyceride levels in the blood rise quickly after you ... with HIV disease have unusually high levels of triglycerides. This is especially true for people taking protease ...

  6. CBC blood test

    MedlinePlus

    ... and fluids, such as from severe diarrhea, excessive sweating, or water pills used to treat high blood pressure Kidney disease with high erythropoietin production Low oxygen level in the blood for a long time, most ...

  7. Where to Donate Blood

    MedlinePlus

    ... HUB AABB Professional Engagement Program (PEP) Association Bulletins Governance and Policies Membership Directory Team Sites Blood FAQ ... Blood Foundation Hemovigilance Membership AABB HUB Membership Directory Corporate Supporters Advertise Copyright © AABB. Privacy Statement | Terms of ...

  8. Osmolality - blood test

    MedlinePlus

    ... blood becomes high, the body releases antidiuretic hormone (ADH). This hormone causes the kidneys to reabsorb water. ... fall back to normal. Low blood osmolality suppresses ADH. This reduces how much water the kidneys reabsorb. ...

  9. Hypertension (High Blood Pressure)

    MedlinePlus

    ... blood pressure with the development of a practical method to measure it. Physicians began to note associations between hypertension and risk of heart failure, stroke, and kidney failure. Although scientists had yet to prove that lowering blood pressure ...

  10. Blood Culture Test

    MedlinePlus

    ... used to detect the presence of bacteria or fungi in the blood, to identify the type present, ... blood cultures to detect and identify bacteria and fungi. Other related tests that may be performed include: ...

  11. Blood Transfusions (For Teens)

    MedlinePlus

    ... re needed. Blood also collects waste products, like carbon dioxide, and takes them to the organs responsible for ... carry oxygen to the body's tissues and remove carbon dioxide. Red blood cells make up about 40%–45% ...

  12. Fueling an Economy with Industrial Training.

    ERIC Educational Resources Information Center

    Raven, Helen C.; LeFiles, Diane C.

    1979-01-01

    A postsecondary training program in various aspects of coal mining has been established in western Maryland through community college credit and noncredit courses leading to a certificate or associate degree for mine employees and others. Maryland's industrial training program includes state aid to industry to provide needed job skills training.…

  13. Center Links Academic/Industry Research.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1980

    1980-01-01

    Discussed is the establishment of a Center University of MassachusettsIndustry Research on Polymers (CUMIRP) at the University's Amherst campus. CUMIRP involves the university, a group of 13 corporations, and the National Science Foundation working together to forge closer research ties between unversities and industry. (Author/DS)

  14. [Demographic transition at the epoch of industrialization].

    PubMed

    Billig, W

    1984-01-01

    The relationship between the early stages of industrialization and population factors in the United Kingdom, France, and the United States is analyzed from a Marxist perspective. The author attempts to associate successive phases of industrialization with phases of the demographic transition. He concludes that no comprehensive general theory concerning this relationship has been established. (summary in ENG, RUS) PMID:12266382

  15. Industry Support

    NASA Technical Reports Server (NTRS)

    2003-01-01

    NASA Glenn Research Center (GRC) is responsible for the Advanced Communications for Air Traffic Management (AC/ATM) Project, a sub-element task of the Advanced Air Transportation Technologies (AATT) Project of the NASA Aviation System Capacity Program (ASC). The AC/ATM Project is developing new communications technologies and tools that will improve throughput in the U.S. Air Traffic Control System. The goal of the AC/ATM Project is to enable a communications infrastructure providing the capacity, efficiency, and flexibility necessary to realize benefits of the future mature Free-Flight environment. The capabilities and scope of communications technologies needed to accomplish this goal depend on characteristics of the future Free-Flight environment. There are many operational concepts being proposed for a future ATM system to enable user flexibility and efficiency. GRC s focus is on developing new technologies and techniques to support the digital communication of information involving airborne and ground-based users. However, the technologies and techniques must be integrated with the systems and services that industry and the Federal Aviation Administration (FAA) are developing. Thus, GRC needs to monitor and provide input to the various industry and FAA organizations and committees that are specifying new systems and services. Adoption of technologies by the FAA is partially dependent on acceptance of the technology by the aviation community. The commercial aviation community in particular would like to adopt technologies that can be used throughout the world. As a result, the adoption of common or at least compatible technologies by European countries is a key factor in getting commitments to those technologies by the US aviation community. GRC desires to keep informed of European activities that relate to aviation communication technologies, particularly those that are being supported by Eurocontrol.

  16. Blood Test: Glucose

    MedlinePlus

    ... Things to Know About Zika & Pregnancy Blood Test: Glucose KidsHealth > For Parents > Blood Test: Glucose Print A A A Text Size What's in ... de sangre: glucosa What It Is A blood glucose test measures the amount of glucose (the main ...

  17. Monitor blood glucose - slideshow

    MedlinePlus

    ... medlineplus.gov/ency/presentations/100220.htm Monitoring blood glucose - Series—Monitoring blood glucose: Using a self-test meter To use the ... A.M. Editorial team. Related MedlinePlus Health Topics Blood Sugar A.D.A.M., Inc. is accredited by ...

  18. Blood Facts and Statistics

    MedlinePlus

    ... Back to Top Facts about the blood donation process Donating blood is a safe process. A sterile needle is used only once for ... discarded. Blood donation is a simple four-step process: registration, medical history and mini-physical, donation and ...

  19. High Blood Pressure (Hypertension)

    MedlinePlus

    ... For Consumers Consumer Information by Audience For Women High Blood Pressure (Hypertension) Share Tweet Linkedin Pin it More sharing options ... En Español Who is at risk? How is high blood pressure treated? Understanding your blood pressure: What do the ...

  20. Indian Supreme Court demands cleaner blood supply.

    PubMed

    Kumar, S

    1996-01-13

    The government of India recently admitted in parliament that 25% of the country's blood banks remain unlicensed. The Supreme Court has directed the government to establish a National Council for Blood Transfusion in an attempt to curb malpractice, malfunctioning, and corruption in the national blood banking system, and to ensure a safe blood supply. Furthermore, the Court advised the government to enact separate legislation for regulating the collection, processing, storage, distribution, and transportation of blood and the operation of blood banks. Legal action will be taken if any blood banks remain ill equipped or unlicensed after the period of one year. Agencies have been directed to take steps to eliminate professional blood selling within two years. They have also been asked to ensure that there are trained drug inspectors to check upon the banks. To boost funding for the councils, the government has been advised to allow 100% exemption upon income tax to those who donate money to the organizations. The Director General of Health Services has been asked to submit a report on action taken by July 16, 1996, to ensure compliance.

  1. Non-invasive blood pressure measurement in mice.

    PubMed

    Feng, Minjie; DiPetrillo, Keith

    2009-01-01

    Hypertension is a leading cause of heart attack, stroke, and kidney failure and represents a serious medical issue worldwide. The genetic basis of hypertension is well-established, but few causal genes have been identified thus far. Non-invasive blood pressure measurements are a critical component of high-throughput genetic studies to identify genes controlling blood pressure. Whereas this technique is fairly routine for blood pressure measurements in rats, non-invasive blood pressure measurement in mice has proven to be more challenging. This chapter describes an experimental protocol measuring blood pressure in mice using a CODA non-invasive blood pressure monitoring system. This method enables accurate blood pressure phenotyping in mice for linkage or mutagenesis studies, as well as for other experiments requiring high-throughput blood pressure measurement.

  2. [Autologous blood transfusion].

    PubMed

    Rosencher, N; Conseiller, C

    2001-06-30

    Autologous blood transfusion techniques are the principal means of reducing allogeneic blood exposure. Those techniques were developed in order to prevent the risk of contamination by viruses, mainly HVB, HCV and HIV. However that risk has become so small that all studies show an exorbitant cost/efficiency ratio. Autologous blood transfusion would therefore be of no interest in terms of public health but a recent experimental study suggested a possible transmission of the BSE agent through blood. Until the matter is settled, the precaution principle means we should prefer alternative techniques to allogeneic blood whenever possible, hence a renewed interest in autologous transfusion. PMID:11503506

  3. Establishing a Local Education Foundation.

    ERIC Educational Resources Information Center

    Pressley, James S.; Markland, Maureen S.

    This paper describes the process of establishing local education foundations for the purpose of raising revenues to supplement, not supplant, existing school programs. Plans to identify funding sources and define the purpose of the foundation tied to student and academic achievement must emerge in order to solicit private individuals or groups,…

  4. Methods for improving PGPR establishment

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Plant growth-promoting rhizobacteria (PGPR) are often touted as a useful means to improve crop productivity and sustainability. However, field studies with PGPR inoculants often result in limited PGPR establishment and colonization, highlighting the need to better understand the factors involved in...

  5. Establishing Time for Professional Learning

    ERIC Educational Resources Information Center

    Journal of Staff Development, 2013

    2013-01-01

    Time for collaborative learning is an essential resource for educators working to implement college- and career-ready standards. The pages in this article include tools from the workbook "Establishing Time for Professional Learning." The tools support a complete process to help educators effectively find and use time. The following…

  6. Establishing Rapport with Deviant Groups

    ERIC Educational Resources Information Center

    Berk, Richard A.; Adams, Joseph M.

    1970-01-01

    Techniques recommended for establishing and maintaining rapport with deviant groups focus on overcoming problems of social distance and mistrust. Although based on experience with juvenile delinquents and drug addicts, the suggestions made are held to offer potential for wider applicability. (RJ)

  7. Establishing Community College Honors Programs.

    ERIC Educational Resources Information Center

    Heck, James

    Drawing from a literature review and survey of community colleges with honors programs, this paper presents a series of recommended strategies and tactics for the establishment and continuation of community college honors programs. The recommendations are structured around the five developmental stages of academic innovation identified by S. V.…

  8. On Establishing Underlying Tonal Contrast

    ERIC Educational Resources Information Center

    Snider, Keith

    2014-01-01

    Phonological field work is largely about establishing contrast in comparable environments. The notion of phonological contrast, however, can be confusing, particularly in its application to tone analysis. Does it mean phonemic contrast in the structuralist sense, or does it mean underlying contrast in the generative sense? Many linguists, in…

  9. Blood groups systems

    PubMed Central

    Mitra, Ranadhir; Mishra, Nitasha; Rath, Girija Prasad

    2014-01-01

    International Society of Blood Transfusion has recently recognized 33 blood group systems. Apart from ABO and Rhesus system, many other types of antigens have been noticed on the red cell membranes. Blood grouping and cross-matching is one of the few important tests that the anaesthesiologist orders during perioperative period. Hence, a proper understanding of the blood group system, their clinical significance, typing and cross-matching tests, and current perspective are of paramount importance to prevent transfusion-related complications. Nonetheless, the knowledge on blood group system is necessary to approach blood group-linked diseases which are still at the stage of research. This review addresses all these aspects of the blood groups system. PMID:25535412

  10. Blood groups systems.

    PubMed

    Mitra, Ranadhir; Mishra, Nitasha; Rath, Girija Prasad

    2014-09-01

    International Society of Blood Transfusion has recently recognized 33 blood group systems. Apart from ABO and Rhesus system, many other types of antigens have been noticed on the red cell membranes. Blood grouping and cross-matching is one of the few important tests that the anaesthesiologist orders during perioperative period. Hence, a proper understanding of the blood group system, their clinical significance, typing and cross-matching tests, and current perspective are of paramount importance to prevent transfusion-related complications. Nonetheless, the knowledge on blood group system is necessary to approach blood group-linked diseases which are still at the stage of research. This review addresses all these aspects of the blood groups system. PMID:25535412

  11. Monitoring Blood Sugar: The Importance of Checking Blood Sugar Levels

    MedlinePlus

    ... Record Keeping The Importance of Checking Blood Sugar Levels Besides helping to keep blood sugar levels (also ... sugar levels. continue How to Check Blood Sugar Levels Blood glucose testing is easier, less painful, and ...

  12. Blood lead levels in radiator repair workers in Colorado.

    PubMed

    Dalton, C B; McCammon, J B; Hoffman, R E; Baron, R C

    1997-01-01

    A laboratory-based blood lead surveillance system in Colorado identified radiator repair workers as having the highest blood lead levels of all worker groups reported. A survey of 42 radiator repair shops in ten locales throughout Colorado was undertaken to estimate the prevalence of workers with elevated blood lead levels > 25 micrograms/dL. The survey was designed to test the sensitivity of the surveillance system and to assess working conditions and practices in the radiator repair industry in Colorado. Of 63 workers, 39 (62%) had blood lead levels > 25 micrograms/dL. The sensitivity of the surveillance system for detecting radiator repair workers with elevated blood lead levels was estimated at 11%. None of the radiator repair shops had adequate local exhaust ventilation. Work practice and engineering modifications are needed to reduce lead exposure in this industry.

  13. Industrial Productivity

    NASA Technical Reports Server (NTRS)

    1977-01-01

    NASTRAN is an offshoot of the computer-design technique used in construction of airplanes and spacecraft. [n this technique engineers create a mathematical model of the aeronautical or space vehicle and "fly" it on the ground by means of computer simulation. The technique enables them to study performance and structural behavior of a number of different designs before settling on the final configuration and proceeding with construction. From this base of aerospace experience, NASA-Goddard developed the NASTRAN general purpose computer program, which offers an exceptionally wide range of analytic capability with regard to structures. NASTRAN has been applied to autos, trucks, railroad cars, ships, nuclear power reactors, steam turbines, bridges, and office buildings. NASA-Langley provides program maintenance services regarded as vital by many NASTRAN users. NASTRAN is essentially a predictive tool. It takes an electronic look at a computerire$.dedgn and reports how the structure will react under a great many different conditions. It can, for example, note areas where high stress levels will occur-potential failure points that need strengthening. Conversely, it can identify over-designed areas where weight and material might be saved safely. NASTRAN can tell how pipes stand up under strong fluid flow, how metals are affected by high temperatures, how a building will fare in an earthquake or how powerful winds will cause a bridge to oscillate. NASTRAN analysis is quick and inexpensive. It minimizes trial-and-error in the design process and makes possible better, safe, lighter structures affording large-scale savings in development time and materials. Some examples of the broad utility NASTRAN is finding among industrial firms are shown on these pages.

  14. Blood porphyrin luminescence and tumor growth correlation

    NASA Astrophysics Data System (ADS)

    Courrol, Lilia Coronato; Silva, Flávia Rodrigues de Oliveira; Bellini, Maria Helena; Mansano, Ronaldo Domingues; Schor, Nestor; Vieira, Nilson Dias, Jr.

    2007-02-01

    Fluorescence technique appears very important for the diagnosis of cancer. Fluorescence detection has advantages over other light-based investigation methods: high sensitivity, high speed, and safety. Renal cell carcinoma (RCC) accounts for approximately 3% of new cancer incidence and mortality in the United States. Unfortunately many RCC masses remain asymptomatic and nonpalpable until they are advanced. Diagnosis and localization of early carcinoma play an important role in the prevention and curative treatment of RCC. Certain drugs or chemicals such as porphyrin derivatives accumulate substantially more in tumors than normal tissues. The autofluorescence of blood porphyrin of healthy and tumor induced male SCID mice was analyzed using fluorescence and excitation spectroscopy. A significant contrast between normal and tumor blood could be established. Blood porphyrin fluorophore showed enhanced fluorescence band (around 630 nm) in function of the tumor growth. This indicates that either the autofluorescence intensity of the blood fluorescence may provide a good parameter for the "first approximation" characterization of the tumor stage.

  15. Blood Far Forward--a whole blood research and training program for austere environments.

    PubMed

    Strandenes, Geir; Cap, Andrew P; Cacic, Daniel; Lunde, Turid Helen Felli; Eliassen, Håkon Skogrand; Hervig, Tor; Spinella, Philip C

    2013-01-01

    The Blood Far Forward (BFF) research program was established to conduct blood product efficacy and safety studies, donor performance studies, and research on optimal training methods to improve the safety of blood collection and transfusion performed by Norwegian Naval Special Operation Commando soldiers. The use of intravenous fluids for volume replacement during hemorrhagic shock is controversial, but it is currently the standard of care. In the far-forward environment, large volume resuscitation for massive bleeding is a great challenge. Crystalloid and colloid solutions add weight and bulk to the medic's kit, require temperature sensitive storage, and should be warmed before infusion to prevent hypothermia. Excessive use of these solutions causes a dilutional coagulopathy, acidosis, and potentially increased inflammatory injury compared with blood products. Type-specific whole blood from an uninjured combat companion on the other hand is almost always available. It is warm, replaces intravascular volume, and provides oxygen delivery and hemostatic capacity to prevent or treat shock and coagulopathy. Whole blood may be ideal for the resuscitation of combat casualties with hemorrhagic shock. BFF program pilot studies on use of platelet-sparing leukoreduction filters, whole blood transport tolerance, donor performance, and autologous reinfusion of 24-hour ambient temperature stored whole blood have been performed and suggest the feasibility of expanding whole blood use in resuscitation. If successful, the BFF program will change tactics, techniques, and procedures with a new lifesaving capability.

  16. Treatment of Established Status Epilepticus.

    PubMed

    Falco-Walter, Jessica J; Bleck, Thomas

    2016-01-01

    Status epilepticus is the most severe form of epilepsy, with a high mortality rate and high health care costs. Status epilepticus is divided into four stages: early, established, refractory, and super-refractory. While initial treatment with benzodiazepines has become standard of care for early status epilepticus, treatment after benzodiazepine failure (established status epilepticus (ESE)) is incompletely studied. Effective treatment of ESE is critical as morbidity and mortality increases dramatically the longer convulsive status epilepticus persists. Phenytoin/fosphenytoin, valproic acid, levetiracetam, phenobarbital, and lacosamide are the most frequently prescribed antiseizure medications for treatment of ESE. To date there are no class 1 data to support pharmacologic recommendations of one agent over another. We review each of these medications, their pharmacology, the scientific evidence in support and against each in the available literature, adverse effects and safety profiles, dosing recommendations, and limitations of the available evidence. We also discuss future directions including the established status epilepticus treatment trial (ESETT). Substantial further research is urgently needed to identify these patients (particularly those with non-convulsive status epilepticus), elucidate the most efficacious antiseizure treatment with head-to-head randomized prospective trials, and determine whether this differs for convulsive vs. non-convulsive ESE. PMID:27120626

  17. Treatment of Established Status Epilepticus

    PubMed Central

    Falco-Walter, Jessica J.; Bleck, Thomas

    2016-01-01

    Status epilepticus is the most severe form of epilepsy, with a high mortality rate and high health care costs. Status epilepticus is divided into four stages: early, established, refractory, and super-refractory. While initial treatment with benzodiazepines has become standard of care for early status epilepticus, treatment after benzodiazepine failure (established status epilepticus (ESE)) is incompletely studied. Effective treatment of ESE is critical as morbidity and mortality increases dramatically the longer convulsive status epilepticus persists. Phenytoin/fosphenytoin, valproic acid, levetiracetam, phenobarbital, and lacosamide are the most frequently prescribed antiseizure medications for treatment of ESE. To date there are no class 1 data to support pharmacologic recommendations of one agent over another. We review each of these medications, their pharmacology, the scientific evidence in support and against each in the available literature, adverse effects and safety profiles, dosing recommendations, and limitations of the available evidence. We also discuss future directions including the established status epilepticus treatment trial (ESETT). Substantial further research is urgently needed to identify these patients (particularly those with non-convulsive status epilepticus), elucidate the most efficacious antiseizure treatment with head-to-head randomized prospective trials, and determine whether this differs for convulsive vs. non-convulsive ESE. PMID:27120626

  18. Assessment of barriers to establish OSH: a country report

    PubMed Central

    ARASTOO, Hadi; HAKIMOVICH, Azimov Pulod; ESFANDIARPOUR, Soraya

    2015-01-01

    In addition to its merits, industrial growth is associated with many issues and problems, including occupational injuries and diseases. The adverse effects of industrialization are function of economic, social, cultural, political and geographical condition of a country, and therefore it varies widely between different countries, especially, developed and developing countries. Establishment of occupational safety and health (OSH) is one of the important solutions to predict, prevent, reduce and harness of the related harms. Despite many relevant protocols and guidelines for establishment of OSH and decades of efforts, still, there are debates and lack of success on different approaches towards implementation of OSH, especially in developing countries. Iran has experienced industrialized growth and has gained some advancement in establishment of OSH in the region. The purpose of this study was to reach to a consensus among Iranian experts about barriers to establish OSH in developing countries, using Delphi technique. 48 experts participated in this study. Two rounds of Delphi were conducted and main barriers were identified, then the identified barriers were prioritized and weighted by the experts. Among all barriers, 17 barriers which were reported by 15 experts or more were selected and categorized as structural, managerial and implementation barriers. PMID:25914069

  19. Thrombin Generation in Zebrafish Blood.

    PubMed

    Schurgers, Evelien; Moorlag, Martijn; Hemker, Coenraad; Lindhout, Theo; Kelchtermans, Hilde; de Laat, Bas

    2016-01-01

    To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemostasis and thrombosis, as the hemostatic system proved to be similar to that in man. Their small size however, has been a hurdle for more widespread use in hemostasis related research. In this study we developed a method that enables the measurement of thrombin generation in a single drop of non-anticoagulated zebrafish blood. Pre-treatment of the fish with inhibitors of FXa and thrombin, resulted in a dose dependent diminishing of thrombin generation, demonstrating the validity of the assay. In order to establish the relationship between whole blood thrombin generation and fibrin formation, we visualized the resulting fibrin network by scanning electron microscopy. Taken together, in this study we developed a fast and reliable method to measure thrombin generation in whole blood collected from a single zebrafish. Given the similarities between coagulation pathways of zebrafish and mammals, zebrafish may be an ideal animal model to determine the effect of novel therapeutics on thrombin generation. Additionally, because of the ease with which gene functions can be silenced, zebrafish may serve as a model organism for mechanistical research in thrombosis and hemostasis. PMID:26872266

  20. Thrombin Generation in Zebrafish Blood

    PubMed Central

    Hemker, Coenraad; Lindhout, Theo; Kelchtermans, Hilde; de Laat, Bas

    2016-01-01

    To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemostasis and thrombosis, as the hemostatic system proved to be similar to that in man. Their small size however, has been a hurdle for more widespread use in hemostasis related research. In this study we developed a method that enables the measurement of thrombin generation in a single drop of non-anticoagulated zebrafish blood. Pre-treatment of the fish with inhibitors of FXa and thrombin, resulted in a dose dependent diminishing of thrombin generation, demonstrating the validity of the assay. In order to establish the relationship between whole blood thrombin generation and fibrin formation, we visualized the resulting fibrin network by scanning electron microscopy. Taken together, in this study we developed a fast and reliable method to measure thrombin generation in whole blood collected from a single zebrafish. Given the similarities between coagulation pathways of zebrafish and mammals, zebrafish may be an ideal animal model to determine the effect of novel therapeutics on thrombin generation. Additionally, because of the ease with which gene functions can be silenced, zebrafish may serve as a model organism for mechanistical research in thrombosis and hemostasis. PMID:26872266

  1. Blood histamine release: A new allergy blood test

    SciTech Connect

    Faraj, B.A.; Gottlieb, G.R.; Camp, V.M.; Lollies, P.

    1985-05-01

    Allergen-mediated histamine release from human leukocytes represents an important model for in vitro studies of allergic reactions. The purpose of this study was to determine whether the measurement of histamine released in allergic patients (pts) by radioenzymatic assay following mixing of their blood with common allergens represents a reliable index for diagnosis of atopic allergy. Three categories of allergies were used: (1) housedust and mite; (2) cat and dog dander; (3) trees and grasses and ragweed mixture. The presence of allergy was established by intradermal skin testing in the study group of 82 pts. Significant atopy was defined as greater than or equal to 3+ (overall range 0-4 +, negative to maximum) on skin testing. The test was carried out in tubes with 0.5 ml heparinized blood, 0.5 ml tris albumin buffer, and one of the allergens (60-100 PNU/ml). In 20 controls without allergy, there always was less than or equal to 4% histamine release (normal response). A significant allergen-mediated histamine release, ranging from 12 to 30% of the total blood histamine content, was observed in 96% of the pts with skin test sensitivity of greater than or equal to 3+. There was good agreement between skin testing and histamine release in terms of the allergen causing the response. Thus, measurement of histamine release in blood in response to allergen challenge represents a clinically useful in vitro test for the diagnosis of atopic allergy. Because data can be obtained from a single sample and are highly quantitative, this new method should have application to the longitudinal study of allergic pts and to the assessment of interventions.

  2. Establishment of the International Power Institute. Final technical report

    SciTech Connect

    Julius E. Coles

    2000-08-04

    The International Power Institute, in collaboration with American industries, seeks to address technical, political, economic and cultural issues of developing countries in the interest of facilitating profitable transactions in power related infrastructure projects. IPI works with universities, governments and commercial organizations to render project-specific recommendations for private-sector investment considerations. IPI also established the following goals: Facilitate electric power infrastructure transactions between developing countries and the US power industry; Collaborate with developing countries to identify development strategies to achieve energy stability; and Encourage market driven solutions and work collaboratively with other international trade energy, technology and banking organizations.

  3. Brain neuroprotection by scavenging blood glutamate.

    PubMed

    Zlotnik, Alexander; Gurevich, Boris; Tkachov, Sergei; Maoz, Ilana; Shapira, Yoram; Teichberg, Vivian I

    2007-01-01

    Excess glutamate in brain fluids characterizes acute brain insults such as traumatic brain injury and stroke. Its removal could prevent the glutamate excitotoxicity that causes long-lasting neurological deficits. As blood glutamate scavenging has been demonstrated to increase the efflux of excess glutamate from brain into blood, we tested the prediction that oxaloacetate-mediated blood glutamate scavenging causes neuroprotection in a pathological situation such as closed head injury (CHI), in which there is a well established deleterious increase of glutamate in brain fluids. We observed highly significant improvements of the neurological status of rats submitted to CHI following an intravenous treatment with 1 mmol oxaloacetate/100 g rat weight which decreases blood glutamate levels by 40%. No detectable therapeutic effect was obtained when rats were treated IV with 1 mmol oxaloacetate together with 1 mmol glutamate/100 g rat. The treatment with 0.005 mmol/100 g rat oxaloacetate was no more effective than saline but when it was combined with the intravenous administration of 0.14 nmol/100 g of recombinant glutamate-oxaloacetate transaminase, recovery was almost complete. Oxaloacetate provided neuroprotection when administered before CHI or at 60 min post CHI but not at 120 min post CHI. Since neurological recovery from CHI was highly correlated with the decrease of blood glutamate levels (r=0.89, P=0.001), we conclude that blood glutamate scavenging affords brain neuroprotection Blood glutamate scavenging may open now new therapeutic options.

  4. Blood flow boosts BMP signaling to keep vessels in shape.

    PubMed

    Franco, Claudio A; Gerhardt, Holger

    2016-09-26

    Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence. PMID:27672213

  5. Acceptability of blood and blood substitutes.

    PubMed

    Ferguson, E; Prowse, C; Townsend, E; Spence, A; Hilten, J A van; Lowe, K

    2008-03-01

    Alternatives to donor blood have been developed in part to meet increasing demand. However, new biotechnologies are often associated with increased perceptions of risk and low acceptance. This paper reviews developments of alternatives and presents data, from a field-based experiment in the UK and Holland, on the risks and acceptance of donor blood and alternatives (chemical, genetically modified and bovine). UK groups perceived all substitutes as riskier than the Dutch. There is a negative association between perceived risk and acceptability. Solutions to increasing acceptance are discussed in terms of implicit attitudes, product naming and emotional responses.

  6. BLOOD DESTRUCTION DURING EXERCISE

    PubMed Central

    Broun, G. O.

    1922-01-01

    The following changes have been demonstrated to take place in the blood of dogs during exercise. 1. An increase in the per cent of cells and hemoglobin in the blood of the jugular vein occurs early in the course of exercise. It probably results from a redistribution of red corpuscles, with an increase in their proportion in the peripheral blood. 2. As exercise is continued, there is a definite increase in plasma volume. 3. A coincident decrease both in the total cell volume and the pigment volume during prolonged exercise suggests that blood destruction then occurs. PMID:19868689

  7. Drying drops of blood

    NASA Astrophysics Data System (ADS)

    Brutin, David; Sobac, Benjamin; Loquet, Boris; Sampol, José.

    2010-11-01

    The drying of a drop of human blood is fascinating by the complexity of the physical mechanisms that occur as well as the beauty of the phenomenon which has never been previously evidenced in the literature. The final stage of full blood evaporation reveals for a healthy person the same regular pattern with a good reproducibility. Other tests on anemia and hyperlipidemic persons were performed and presented different patterns. By means of digital camera, the influence of the motion of red blood cells (RBCs) which represent about 50% of the blood volume, is revealed as well as its consequences on the final stages of drying. The mechanisms which lead to the final pattern of dried blood drops are presented and explained on the basis of fluid and solid mechanics in conjunction with the principles of hematology. Our group is the first to evidence that the specific regular patterns characteristic of a healthy individual do not appear in a dried drop of blood from a person with blood disease. Blood is a complex colloidal suspension for which the flow motion is clearly non-Newtonian. When drops of blood evaporate, all the colloids are carried by the flow motion inside the drop and interact.

  8. Industry liaison section implementation plan

    NASA Technical Reports Server (NTRS)

    Lakowske, Stephen

    1990-01-01

    The Industry Liaison Section is a new function of the Army/NASA Aircrew-Aircraft Integration (AAAI) Program that is intended to bridge an existing gap between Government developers (including contractors) and outside organizations who are potential users of products and services developed by the AAAI Program. Currently in its sixth year, the Program is experiencing considerable pull from industry and other government organizations to disseminate products. Since the AAAI Program's charter is exploratory and research in nature, and satisfying proper dissemination requirements is in conflict with the rapid prototyping approach utilized by the design team, the AAAI Program has elected to create an Industry Liaison Section (ILS) to serve as the Program's technology transfer focal point. The process by which the ILS may be established, organized and managed is described, including the baseline organizational structure, duties, functions, authority, responsibilities, relations and policies and procedures relevant to the conduct of the ILS.

  9. A Testing Service for Industry

    NASA Technical Reports Server (NTRS)

    1994-01-01

    A small isolated NASA facility provides assistance to industry in the design, testing, and operation of oxygen systems. White Sands Test Facility (WSTF) was originally established to test rocket propulsion systems for the Apollo program. The facility's role was later expanded into testing characterization, flammability and toxicity characteristics of materials. Its materials and components test methods were adopted by the American society for Testing and Materials. When research and testing results became known, industry requested assistance, and in 1980, NASA authorized WSTF to open its facility to private firms, a valuable service, as oxygen systems testing is often too expensive and too hazardous for many companies. Today, some of the best known American industries utilize White Sands testing capabilities.

  10. The chemical industry, by country

    SciTech Connect

    Not Available

    1995-03-01

    Beijing will be the site for the third ACHEMASIA, international petrochemical and chemical exhibition and conference, May 15--20, 1995. In preparation for this conference, Hydrocarbon Processing contacted executives of petrochemical/chemical industries and trade associations, seeking views on the state of the industry. The Asia-Pacific region is the center of new construction and expanded capacity and also a mixture of mature, developing and emerging petrochemical industries. Established countries must mold and grow with emerging economies as the newcomers access natural resources and develop their own petrochemical infrastructures. The following nation reports focus on product supply/demand trends, economic forecasts, new construction, etc. Space limitations prohibit publishing commentaries from all countries that have petrochemical/chemical capacity. Reports are published from the following countries: Australia, China, Japan, Korea, Malaysia, Philippines, Thailand, and Vietnam.

  11. [Blood in art, art in blood].

    PubMed

    Danic, B; Lefrère, J-J

    2010-12-01

    In the different forms of art developed by Humanity over the centuries, artists have at times chosen themes from the world of medicine or health, such as blood donation or transfusion. In order to illustrate this, we have looked at three artistic domains: painting, movies and body art.

  12. 75 FR 14564 - Dairy Industry Advisory Committee; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... Farm Service Agency Dairy Industry Advisory Committee; Public Meeting AGENCY: Farm Service Agency, USDA..., the Farm Service Agency (FSA) announces a public meeting of the newly established Dairy Industry Advisory Committee (Dairy Committee) to review the current state of the dairy industry, discuss...

  13. Establishing nuclear facility drill programs

    SciTech Connect

    1996-03-01

    The purpose of DOE Handbook, Establishing Nuclear Facility Drill Programs, is to provide DOE contractor organizations with guidance for development or modification of drill programs that both train on and evaluate facility training and procedures dealing with a variety of abnormal and emergency operating situations likely to occur at a facility. The handbook focuses on conducting drills as part of a training and qualification program (typically within a single facility), and is not intended to included responses of personnel beyond the site boundary, e.g. Local or State Emergency Management, Law Enforcement, etc. Each facility is expected to develop its own facility specific scenarios, and should not limit them to equipment failures but should include personnel injuries and other likely events. A well-developed and consistently administered drill program can effectively provide training and evaluation of facility operating personnel in controlling abnormal and emergency operating situations. To ensure the drills are meeting their intended purpose they should have evaluation criteria for evaluating the knowledge and skills of the facility operating personnel. Training and evaluation of staff skills and knowledge such as component and system interrelationship, reasoning and judgment, team interactions, and communications can be accomplished with drills. The appendices to this Handbook contain both models and additional guidance for establishing drill programs at the Department`s nuclear facilities.

  14. Fresh Whole Blood Transfusion: Military and Civilian Implications.

    PubMed

    Goforth, Carl W; Tranberg, John W; Boyer, Phillip; Silvestri, Peter J

    2016-06-01

    Uncontrolled hemorrhage and exsanguination are the leading cause of preventable death, and resuscitative therapy is a critical component for survival. In various combinations, fresh whole blood, blood components, colloids, and crystalloids have all been staples of trauma care. The use of fresh whole blood is a well-established military practice that has saved the lives of thousands of American and coalition military personnel. Civilian use of fresh whole blood is far less established owing to the wide availability of individual blood components. However, this highly tailored blood supply is vulnerable to both natural and man-made disasters. In the event of such disruption, such as a major hurricane, it may be necessary for civilian hospitals to rapidly enact a fresh whole blood program. Therefore, the aim of this article is to review the current use of blood therapy for trauma resuscitation, the US military's approach to fresh whole blood, and how maintaining a civilian capacity for fresh whole blood collection in the event of future man-made and natural disasters is key to promoting survival from trauma. PMID:27252101

  15. Challenges in the management of the blood supply.

    PubMed

    Williamson, Lorna M; Devine, Dana V

    2013-05-25

    Although blood suppliers are seeing short-term reductions in blood demand as a result of initiatives in patient blood management, modelling suggests that during the next 5-10 years, blood availability in developed countries will need to increase again to meet the demands of ageing populations. Increasing of the blood supply raises many challenges; new approaches to recruitment and retainment of future generations of blood donors will be needed, and care will be necessary to avoid taking too much blood from these donors. Integrated approaches in blood stock management between transfusion services and hospitals will be important to minimise wastage--eg, by use of supply chain solutions from industry. Cross-disciplinary systems for patient blood management need to be developed to lessen the need for transfusion--eg, by early identification and reversal of anaemia with haematinics or by reversal of the underlying cause. Personalised medicine could be applied to match donors to patients, not only with extended blood typing, but also by using genetically determined storage characteristics of blood components. Growing of red cells or platelets in large quantities from stem cells is a possibility in the future, but challenges of cost, scaling up, and reproducibility remain to be solved. PMID:23706803

  16. Challenges in the management of the blood supply.

    PubMed

    Williamson, Lorna M; Devine, Dana V

    2013-05-25

    Although blood suppliers are seeing short-term reductions in blood demand as a result of initiatives in patient blood management, modelling suggests that during the next 5-10 years, blood availability in developed countries will need to increase again to meet the demands of ageing populations. Increasing of the blood supply raises many challenges; new approaches to recruitment and retainment of future generations of blood donors will be needed, and care will be necessary to avoid taking too much blood from these donors. Integrated approaches in blood stock management between transfusion services and hospitals will be important to minimise wastage--eg, by use of supply chain solutions from industry. Cross-disciplinary systems for patient blood management need to be developed to lessen the need for transfusion--eg, by early identification and reversal of anaemia with haematinics or by reversal of the underlying cause. Personalised medicine could be applied to match donors to patients, not only with extended blood typing, but also by using genetically determined storage characteristics of blood components. Growing of red cells or platelets in large quantities from stem cells is a possibility in the future, but challenges of cost, scaling up, and reproducibility remain to be solved.

  17. 5 CFR 532.223 - Establishments included in regular nonappropriated fund surveys.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... employees in the prescribed industries within a survey area must be included in the survey universe. Establishments in NAICS codes 4471, 4542, 71391, and 71395 must be included in the survey universe if they...

  18. 5 CFR 532.223 - Establishments included in regular nonappropriated fund surveys.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... employees in the prescribed industries within a survey area must be included in the survey universe. Establishments in NAICS codes 4471, 4542, 71391, and 71395 must be included in the survey universe if they...

  19. 5 CFR 532.223 - Establishments included in regular nonappropriated fund surveys.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... employees in the prescribed industries within a survey area must be included in the survey universe. Establishments in NAICS codes 4471, 4542, 71391, and 71395 must be included in the survey universe if they...

  20. 5 CFR 532.223 - Establishments included in regular nonappropriated fund surveys.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... employees in the prescribed industries within a survey area must be included in the survey universe. Establishments in NAICS codes 4471, 4542, 71391, and 71395 must be included in the survey universe if they...

  1. 5 CFR 532.223 - Establishments included in regular nonappropriated fund surveys.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... employees in the prescribed industries within a survey area must be included in the survey universe. Establishments in NAICS codes 4471, 4542, 71391, and 71395 must be included in the survey universe if they...

  2. Blood culture contaminants.

    PubMed

    Dawson, S

    2014-05-01

    Blood cultures are an essential diagnostic tool. However, contamination may impact on patients' care and lead to increased patient stay, additional tests, and inappropriate antibiotic use. The aim of this study was to review the literature for factors that influence the rate of blood culture contamination. A comprehensive literature search was performed using Medline and CINAHL on blood culture contamination. Hospitals/units should have in place a protocol for staff on how to take blood cultures, incorporating use of an aseptic technique. Studies have shown that several key factors in the process may lower contamination rates such as adherence to a protocol, sampling by peripheral venepuncture route rather than via an intravascular catheter, use of sterile gloves, cleaning tops of blood culture bottles with antiseptics and inoculating blood culture bottles before other blood tubes, samples being taken by a phlebotomy team, monitoring contamination rates, and providing individual feedback and retraining for those with contaminants. Although skin antisepsis is advocated there is still debate on which antiseptic is most effective, as there is no conclusive evidence, only that there is benefit from alcohol-containing preparations. In conclusion, hospitals should aim to minimize their blood culture contamination rates. They should monitor their rate regularly and aim for a rate of ≤3%. PMID:24768211

  3. Blood culture contaminants.

    PubMed

    Dawson, S

    2014-05-01

    Blood cultures are an essential diagnostic tool. However, contamination may impact on patients' care and lead to increased patient stay, additional tests, and inappropriate antibiotic use. The aim of this study was to review the literature for factors that influence the rate of blood culture contamination. A comprehensive literature search was performed using Medline and CINAHL on blood culture contamination. Hospitals/units should have in place a protocol for staff on how to take blood cultures, incorporating use of an aseptic technique. Studies have shown that several key factors in the process may lower contamination rates such as adherence to a protocol, sampling by peripheral venepuncture route rather than via an intravascular catheter, use of sterile gloves, cleaning tops of blood culture bottles with antiseptics and inoculating blood culture bottles before other blood tubes, samples being taken by a phlebotomy team, monitoring contamination rates, and providing individual feedback and retraining for those with contaminants. Although skin antisepsis is advocated there is still debate on which antiseptic is most effective, as there is no conclusive evidence, only that there is benefit from alcohol-containing preparations. In conclusion, hospitals should aim to minimize their blood culture contamination rates. They should monitor their rate regularly and aim for a rate of ≤3%.

  4. Red blood cell production

    MedlinePlus

    ... cells are an important element of blood. Their job is to transport oxygen to the body’s tissues in exchange for carbon dioxide, which is carried to and eliminated by the lungs. Red blood cells are formed in the red bone marrow of bones. Stem cells in the red bone marrow called hemocytoblasts ...

  5. Cord blood testing

    MedlinePlus

    ... gases (to evaluate the oxygen, carbon dioxide, and pH levels) Blood sugar level Blood type and Rh Complete ... A low pH (less than 7.04 to 7.10) means there are higher levels ... This might occur when the baby does not get enough oxygen during ...

  6. Low blood sugar - newborns

    MedlinePlus

    ... neonatal hypoglycemia. It refers to low blood sugar (glucose) in the first few days after birth. ... Babies need blood sugar (glucose) for energy. Most of that glucose is used by the brain. The baby gets glucose from the mother through the ...

  7. Portable automatic blood analyzer

    NASA Technical Reports Server (NTRS)

    Coleman, R. L.

    1975-01-01

    Analyzer employs chemical-sensing electrodes for determination of blood, gas, and ion concentrations. It is rugged, easily serviced, and comparatively simple to operate. System can analyze up to eight parameters and can be modified to measure other blood constituents including nonionic species, such as urea, glucose, and oxygen.

  8. An Impact Analysis of Regional Industry--University Interactions: The Case of Industrial PhD Schools

    ERIC Educational Resources Information Center

    Gustavsson, Linda; Nuur, Cali; Söderlind, Johan

    2016-01-01

    The authors discuss Triple Helix collaborations in the context of regional competitiveness. Through an exploratory case study, they identify and analyse the impact of the establishment of industrial PhD schools for participating industry and universities. The study was conducted in Sweden in 2014 and focuses on three industry--university…

  9. Blood Pressure Checker

    NASA Technical Reports Server (NTRS)

    1979-01-01

    An estimated 30 million people in the United States have high blood pressure, or hypertension. But a great many of them are unaware of it because hypertension, in its initial stages, displays no symptoms. Thus, the simply-operated blood pressure checking devices now widely located in public places are useful health aids. The one pictured above, called -Medimax 30, is a direct spinoff from NASA technology developed to monitor astronauts in space. For manned space flights, NASA wanted a compact, highly-reliable, extremely accurate method of checking astronauts' blood pressure without the need for a physician's interpretive skill. NASA's Johnson Space Center and Technology, Inc., a contractor, developed an electronic sound processor that automatically analyzes blood flow sounds to get both systolic (contracting arteries) and diastolic (expanding arteries) blood pressure measurements. NASA granted a patent license for this technology to Advanced Life Sciences, Inc., New York City, manufacturers of Medimax 30.

  10. Blood-type distribution

    NASA Astrophysics Data System (ADS)

    Kim, Beom Jun; Myeong Lee, Dong; Hun Lee, Sung; Gim, Wan-Suk

    2007-01-01

    We statistically verify the Hardy-Weinberg principle in genetics by investigating the independence of ABO-blood types of married couples. The allelic frequencies derived from the phenotypic frequencies in ethnic groups via the Hardy-Weinberg principle are used to define a genetic distance (called the blood distance in this work) between two groups. The blood distances are compared with the geographic distances, and then used to construct a network of ethnic groups. We also investigate the relationship between the ABO blood types and the human personalities, gauged by the Myers-Briggs-type indicator (MBTI) psychological test. The statistical χ2-test reveals the independence between the blood types and MBTI results with an exception of type B males. A psychological implication is discussed.

  11. Bioengineered blood vessels.

    PubMed

    Niu, Guoguang; Sapoznik, Etai; Soker, Shay

    2014-04-01

    Cardiovascular disease (CVD) affecting blood vessel function is a leading cause of death around the world. A common treatment option to replace the diseased blood vessels is vascular grafting using the patient's own blood vessels. However, patients with CVD are usually lacking vessels for grafting. Recent advances in tissue engineering are now providing alternatives to autologous vascular grafts in the form of tissue-engineered blood vessels (TEBVs). In this review, we will describe the use of different scaffolding systems, cell sources and conditioning approaches for creating fully functional blood vessels. Additionally, we will present the methods used for assessing TEBV functions and describe preclinical and clinical trials for TEBV. Although the early results were encouraging, current designs of TEBV still fall short as a viable clinical option. Implementing the current knowledge in vascular development can lead to improved fabrication and function of TEBV and hasten clinical translation.

  12. Mechanics of blood flow.

    PubMed

    Skalak, R; Keller, S R; Secomb, T W

    1981-05-01

    The historical development of the mechanics of blood flow can be traced from ancient times, to Leonardo da Vinci and Leonhard Euler and up to the present times with increasing biological knowledge and mathematical analysis. In the last two decades, quantitative and numerical methods have steadily given more complete and precise understanding. In the arterial system wave propagation computations based on nonlinear one-dimensional modeling have given the best representation of pulse wave propagation. In the veins, the theory of unsteady flow in collapsible tubes has recently been extensively developed. In the last decade, progress has been made in describing the blood flow at junctions, through stenoses, in bends and in capillary blood vessels. The rheological behavior of individual red blood cells has been explored. A working model consists of an elastic membrane filled with viscous fluid. This model forms a basis for understanding the viscous and viscoelastic behavior of blood. PMID:7024641

  13. Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth.

    PubMed

    Koo, Yeon; Barry, David M; Xu, Ke; Tanigaki, Keiji; Davis, George E; Mineo, Chieko; Cleaver, Ondine

    2016-04-01

    Cardiovascular function depends on patent, continuous and stable blood vessel formation by endothelial cells (ECs). Blood vessel development initiates by vasculogenesis, as ECs coalesce into linear aggregates and organize to form central lumens that allow blood flow. Molecular mechanisms underlying in vivo vascular 'tubulogenesis' are only beginning to be unraveled. We previously showed that the GTPase-interacting protein called Rasip1 is required for the formation of continuous vascular lumens in the early embryo. Rasip1(-/-) ECs exhibit loss of proper cell polarity and cell shape, disrupted localization of EC-EC junctions and defects in adhesion of ECs to extracellular matrix. In vitro studies showed that Rasip1 depletion in cultured ECs blocked tubulogenesis. Whether Rasip1 is required in blood vessels after their initial formation remained unclear. Here, we show that Rasip1 is essential for vessel formation and maintenance in the embryo, but not in quiescent adult vessels. Rasip1 is also required for angiogenesis in three models of blood vessel growth: in vitro matrix invasion, retinal blood vessel growth and directed in vivo angiogenesis assays. Rasip1 is thus necessary in growing embryonic blood vessels, postnatal angiogenic sprouting and remodeling, but is dispensable for maintenance of established blood vessels, making it a potential anti-angiogenic therapeutic target.

  14. Chemicals Industry Vision

    SciTech Connect

    none,

    1996-12-01

    Chemical industry leaders articulated a long-term vision for the industry, its markets, and its technology in the groundbreaking 1996 document Technology Vision 2020 - The U.S. Chemical Industry. (PDF 310 KB).

  15. Professors and Industry Meet

    ERIC Educational Resources Information Center

    Sheriff, Robert E.

    1974-01-01

    Describes backgrounds of geophysics graduates that are desired for employment by industry. Also listed are areas in which industry could help universities concerning the development of programs to meet the future manpower needs in industry. (BR)

  16. Mammography calibration qualities establishment in a Mo- Mo clinical system

    NASA Astrophysics Data System (ADS)

    Corrêa, E. L.; dos Santos, L. R.; Vivolo, V.; Potiens, M. P. A.

    2016-07-01

    In this study the mammography calibration qualities were established in a clinical mammography system. The objective is to provide the IPEN instruments calibration laboratory with both mammography calibration methods (using a clinical and an industrial system). The results showed a good behavior of mammography equipment, in terms of kVp, PPV and exposure time. The additional filtration of molybdenum is adequate, air-kerma rates were determined and spectra were obtained.

  17. Quality of transfusion products in blood banking.

    PubMed

    Franchini, Massimo; Capuzzo, Enrico; Turdo, Rosalia; Glingani, Claudia

    2014-03-01

    The primary goal in transfusion medicine and cellular therapies is to promote high standards of quality and produce ever safer and more efficacious products. The establishment of a transfusion service quality management system, which includes several organizational structures, responsibilities, policies, processes, procedures, and resources, is now mandatory and widely regulated worldwide. In this review, we summarize the current knowledge on the quality system in transfusion medicine as applied to the production of blood components, including red blood cells, platelets, and fresh frozen plasma. PMID:24474089

  18. Legal and ethical issues in safe blood transfusion

    PubMed Central

    Chandrashekar, Shivaram; Kantharaj, Ambuja

    2014-01-01

    Legal issues play a vital role in providing a framework for the Indian blood transfusion service (BTS), while ethical issues pave the way for quality. Despite licensing of all blood banks, failure to revamp the Drugs and Cosmetic Act (D and C Act) is impeding quality. Newer techniques like chemiluminescence or nucleic acid testing (NAT) find no mention in the D and C Act. Specialised products like pooled platelet concentrates or modified whole blood, therapeutic procedures like erythropheresis, plasma exchange, stem cell collection and processing technologies like leukoreduction and irradiation are not a part of the D and C Act. A highly fragmented BTS comprising of over 2500 blood banks, coupled with a slow and tedious process of dual licensing (state and centre) is a hindrance to smooth functioning of blood banks. Small size of blood banks compromises blood safety. New blood banks are opened in India by hospitals to meet requirements of insurance providers or by medical colleges as this a Medical Council of India (MCI) requirement. Hospital based blood banks opt for replacement donation as they are barred by law from holding camps. Demand for fresh blood, lack of components, and lack of guidelines for safe transfusion leads to continued abuse of blood. Differential pricing of blood components is difficult to explain scientifically or ethically. Accreditation of blood banks along with establishment of regional testing centres could pave the way to blood safety. National Aids Control Organisation (NACO) and National Blood Transfusion Council (NBTC) deserve a more proactive role in the licensing process. The Food and Drug Administration (FDA) needs to clarify that procedures or tests meant for enhancement of blood safety are not illegal. PMID:25535417

  19. Legal and ethical issues in safe blood transfusion.

    PubMed

    Chandrashekar, Shivaram; Kantharaj, Ambuja

    2014-09-01

    Legal issues play a vital role in providing a framework for the Indian blood transfusion service (BTS), while ethical issues pave the way for quality. Despite licensing of all blood banks, failure to revamp the Drugs and Cosmetic Act (D and C Act) is impeding quality. Newer techniques like chemiluminescence or nucleic acid testing (NAT) find no mention in the D and C Act. Specialised products like pooled platelet concentrates or modified whole blood, therapeutic procedures like erythropheresis, plasma exchange, stem cell collection and processing technologies like leukoreduction and irradiation are not a part of the D and C Act. A highly fragmented BTS comprising of over 2500 blood banks, coupled with a slow and tedious process of dual licensing (state and centre) is a hindrance to smooth functioning of blood banks. Small size of blood banks compromises blood safety. New blood banks are opened in India by hospitals to meet requirements of insurance providers or by medical colleges as this a Medical Council of India (MCI) requirement. Hospital based blood banks opt for replacement donation as they are barred by law from holding camps. Demand for fresh blood, lack of components, and lack of guidelines for safe transfusion leads to continued abuse of blood. Differential pricing of blood components is difficult to explain scientifically or ethically. Accreditation of blood banks along with establishment of regional testing centres could pave the way to blood safety. National Aids Control Organisation (NACO) and National Blood Transfusion Council (NBTC) deserve a more proactive role in the licensing process. The Food and Drug Administration (FDA) needs to clarify that procedures or tests meant for enhancement of blood safety are not illegal.

  20. Establishing Liver Bioreactors for In Vitro Research.

    PubMed

    Rebelo, Sofia P; Costa, Rita; Sousa, Marcos F Q; Brito, Catarina; Alves, Paula M

    2015-01-01

    In vitro systems that can effectively model liver function for long periods of time are fundamental tools for preclinical research. Nevertheless, the adoption of in vitro research tools at the earliest stages of drug development has been hampered by the lack of culture systems that offer the robustness, scalability, and flexibility necessary to meet industry's demands. Bioreactor-based technologies, such as stirred tank bioreactors, constitute a feasible approach to aggregate hepatic cells and maintain long-term three-dimensional cultures. These three-dimensional cultures sustain the polarity, differentiated phenotype, and metabolic performance of human hepatocytes. Culture in computer-controlled stirred tank bioreactors allows the maintenance of physiological conditions, such as pH, dissolved oxygen, and temperature, with minimal fluctuations. Moreover, by operating in perfusion mode, gradients of soluble factors and metabolic by-products can be established, aiming at resembling the in vivo microenvironment. This chapter provides a protocol for the aggregation and culture of hepatocyte spheroids in stirred tank bioreactors by applying perfusion mode for the long-term culture of human hepatocytes. This in vitro culture system is compatible with feeding high-throughput screening platforms for the assessment of drug elimination pathways, being a useful tool for toxicology research and drug development in the preclinical phase.