Sample records for ineligible study design

  1. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for Temporary...

  2. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for Temporary...

  3. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for Temporary...

  4. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for Temporary...

  5. 8 CFR 244.4 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 244.4 Section 244.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.4 Ineligible aliens. An alien is ineligible for Temporary...

  6. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An alien...

  7. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An alien...

  8. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An alien...

  9. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An alien...

  10. 8 CFR 1244.4 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 1244.4 Section 1244.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.4 Ineligible aliens. An alien...

  11. 47 CFR 54.631 - Designation of Consortium Leader.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (CONTINUED) UNIVERSAL SERVICE Universal Service Support for Health Care Providers Healthcare Connect Fund... support from the Healthcare Connect Fund must identify an entity or organization that will be the lead... entity), or non-profit entity that is ineligible for Healthcare Connect Fund support. Ineligible state...

  12. 47 CFR 54.631 - Designation of Consortium Leader.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (CONTINUED) UNIVERSAL SERVICE Universal Service Support for Health Care Providers Healthcare Connect Fund... support from the Healthcare Connect Fund must identify an entity or organization that will be the lead... entity), or non-profit entity that is ineligible for Healthcare Connect Fund support. Ineligible state...

  13. 7 CFR 1948.59 - Ineligible activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... Program § 1948.59 Ineligible activities. (a) Growth management and housing planning grant funds may not be... Governments;” (5) Planning for areas other than approved designated areas; (6) Planning other than growth...

  14. Differences in clinical outcome between docetaxel and abiraterone acetate as the first-line treatment in chemo-naïve metastatic castration-resistant prostate cancer patients with or without the ineligible clinical factors of the COU-AA-302 study.

    PubMed

    Poon, Darren M C; Chan, Kuen; Lee, Siu H; Chan, Tim W; Sze, Henry; Lee, Eric K C; Lam, Daisy; Chan, Michelle F T

    2018-03-01

    This study aimed to compare the efficacy of abiraterone acetate (AA) versus docetaxel (T) as first-line treatment in chemo-naïve metastatic castration-resistant prostate cancer (mCRPC) patients with or without the ineligible factors of the COU-AA-302 study (presence of visceral metastases, symptomatic disease, and/or Eastern Cooperative Oncology Group performance status ≥ 2). The clinical records of chemo-naïve mCRPC patients who received AA in six public oncology centers or T in two of these centers between 2003 and 2014 were reviewed. The survival time was compared among four subgroups of patients: those with ineligible factors administered AA (Group Ineligible-AA) or T (Group Ineligible-T), and those without ineligible factors and administered AA (Group Eligible-AA) or T (Group Eligible-T). During the study period, we identified 115 mCRPC patients who received AA or T, among whom 29, 36, 29, and 21 patients were classified as Groups Ineligible-AA, Ineligible-T, Eligible-AA, and Eligible-T, respectively. Both Group Ineligible-AA and Group Eligible-AA had significantly longer progression-free survival (PFS) and similar overall survival (OS) as Group Ineligible-T and Group Eligible-T (Ineligible, PFS: 6.3 vs. 5.9 months, P  = 0.0234, OS: 7.8 vs. 15.7 months, P  = 0.1601; Eligible, PFS: 9.8 vs. 5.6 months, P  = 0.0437, OS: 20.5 vs. 18.2 months, P  = 0.7820). Compared to T, AA treatment resulted in longer PFS and similar OS in chemo-naïve mCRPC patients, irrespective of the presence of ineligible factors, suggesting that the initial treatment by AA may still be beneficial to those with the aforementioned ineligible factors.

  15. 21 CFR 1404.960 - Ineligible or ineligibility.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Ineligible or ineligibility. 1404.960 Section 1404.960 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 1404.960 Ineligible or ineligibility. Ineligible or ineligibility means that a...

  16. Co-enrollment in multiple HIV prevention trials - experiences from the CAPRISA 004 Tenofovir gel trial.

    PubMed

    Karim, Quarraisha Abdool; Kharsany, Ayesha B M; Naidoo, Kasavan; Yende, Nonhlanhla; Gengiah, Tanuja; Omar, Zaheen; Arulappan, Natasha; Mlisana, Koleka P; Luthuli, Londiwe R; Karim, Salim S Abdool

    2011-05-01

    In settings where multiple HIV prevention trials are conducted in close proximity, trial participants may attempt to enroll in more than one trial simultaneously. Co-enrollment impacts on participant's safety and validity of trial results. We describe our experience, remedial action taken, inter-organizational collaboration and lessons learnt following the identification of co-enrolled participants. Between February and April 2008, we identified 185 of the 398 enrolled participants as ineligible. In violation of the study protocol exclusion criteria, there was simultaneous enrollment in another HIV prevention trial (ineligible co-enrolled, n=135), and enrollment of women who had participated in a microbicide trial within the past 12 months (ineligible not co-enrolled, n=50). Following a complete audit of all enrolled participants, ineligible participants were discontinued via study exit visits from trial follow-up. Custom-designed education program on co-enrollment impacting on participants' safety and validity of the trial results was implemented. Shared electronic database between research units was established to enable verification of each volunteer's trial participation and to prevent future co-enrollments. Interviews with ineligible enrolled women revealed that high-quality care, financial incentives, altruistic motives, preference for sex with gel, wanting to increase their likelihood of receiving active gel, perceived low risk of discovery and peer pressure are the reasons for their enrollment in the CAPRISA 004 trial. Instituting education programs based on the reasons reported by women for seeking enrollment in more than one trial and using a shared central database system to identify co-enrollments have effectively prevented further co-enrollments. Copyright © 2011 Elsevier Inc. All rights reserved.

  17. The generalizability of bronchiectasis randomized controlled trials: A multicentre cohort study.

    PubMed

    Chalmers, James D; McDonnell, Melissa J; Rutherford, Robert; Davidson, John; Finch, Simon; Crichton, Megan; Dupont, Lieven; Hill, Adam T; Fardon, Thomas C; De Soyza, Anthony; Aliberti, Stefano; Goeminne, Pieter

    2016-03-01

    Randomized controlled trials (RCTs) for bronchiectasis have experienced difficulties with recruitment and in reaching their efficacy end-points. To estimate the generalizability of such studies we applied the eligibility criteria for major RCTs in bronchiectasis to 6 representative observational European Bronchiectasis cohorts. Inclusion and exclusion criteria from 10 major RCTs were applied in each cohort. Demographics and outcomes were compared between patients eligible and ineligible for RCTs. 1672 patients were included. On average 33.0% were eligible for macrolide trials, 15.0% were eligible for inhaled antibiotic trials, 15.9% for the DNAse study and 47.7% were eligible for a study of dry powder mannitol. Within these groups, some trials were highly selective with only 1-9% of patients eligible. Eligible patients were generally more severe with higher mortality during follow-up (mean 17.2 vs 9.0% for macrolide studies, 19.2%% vs 10.7% for inhaled antibiotic studies), and a higher frequency of exacerbations than ineligible patients. As up to 93% of patients were ineligible for studies, however, numerically more deaths and exacerbations occurred in ineligible patient across studies (mean 56% of deaths occurred in ineligible patients across all studies). Our data suggest that patients enrolled in RCT's in bronchiectasis are only partially representative of patients in clinical practice. The majority of mortality and morbidity in bronchiectasis occurs in patients ineligible for many current trials. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Higher Education. Verification Helps Prevent Student Aid Payments to Ineligible Noncitizens. Report to Congressional Committees.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Health, Education, and Human Services Div.

    This report assesses the extent to which ineligible noncitizens receive postsecondary federal student financial assistance. The study focused on the following issues: (1) processes needed to ensure that ineligible noncitizens do not receive federal student aid under Title IV of the Higher Education Act, (2) the numbers of potentially ineligible…

  19. 44 CFR 204.43 - Ineligible costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Ineligible costs. 204.43... Ineligible costs. Costs not directly associated with the incident period are ineligible. Ineligible costs include the following: (a) Costs incurred in the mitigation, management, and control of undeclared fires...

  20. All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study.

    PubMed

    Manns, Michael; Pol, Stanislas; Jacobson, Ira M; Marcellin, Patrick; Gordon, Stuart C; Peng, Cheng-Yuan; Chang, Ting-Tsung; Everson, Gregory T; Heo, Jeong; Gerken, Guido; Yoffe, Boris; Towner, William J; Bourliere, Marc; Metivier, Sophie; Chu, Chi-Jen; Sievert, William; Bronowicki, Jean-Pierre; Thabut, Dominique; Lee, Youn-Jae; Kao, Jia-Horng; McPhee, Fiona; Kopit, Justin; Mendez, Patricia; Linaberry, Misti; Hughes, Eric; Noviello, Stephanie

    2014-11-01

    An unmet need exists for interferon-free and ribavirin-free treatments for chronic hepatitis C virus (HCV) infection. In this study, we assessed all-oral therapy with daclatasvir (NS5A replication complex inhibitor) plus asunaprevir (NS3 protease inhibitor) in patients with genotype 1b infection, including those with high unmet needs or cirrhosis, or both. We did this phase 3, multicohort study (HALLMARK-DUAL) at 116 sites in 18 countries between May 11, 2012, and Oct 9, 2013. Patients were adults with chronic HCV genotype 1b infection who were treatment-naive; previous non-responders to peginterferon alfa plus ribavirin; or medically ineligible for, previously intolerant of, or ineligible for and intolerant of peginterferon alfa plus ribavirin. Treatment-naive patients were randomly assigned (2:1 ratio) by an interactive voice-response system with a computer-generated random allocation sequence (stratified by cirrhosis status) to receive daclatasvir 60 mg once daily plus asunaprevir 100 mg twice daily or placebo for 12 weeks. Patients and investigator sites were masked to treatment assignment and HCV RNA results to the end of week 12. The treatment-naive group assigned to daclatasvir plus asunaprevir continued open-label treatment to the end of week 24; participants assigned to placebo entered another daclatasvir plus asunaprevir study. Non-responders and ineligible, intolerant, or ineligible and intolerant patients received open-label daclatasvir plus asunaprevir for 24 weeks. The primary endpoint was sustained virological response at post-treatment week 12. Efficacy analyses were restricted to patients given daclatasvir plus asunaprevir. This trial is registered with ClinicalTrials.gov, number NCT01581203. This study included 307 treatment-naive patients (205 received daclatasvir plus asunaprevir and 102 received placebo; all randomly assigned patients received the intended treatment), 205 non-responders, and 235 ineligible, intolerant, or ineligible and intolerant patients. Daclatasvir plus asunaprevir provided sustained virological response in 182 (90%, 95% CI 85-94) patients in the treatment-naive cohort, 168 (82%, 77-87) in the non-responder cohort, and 192 (82%, 77-87) in the ineligible, intolerant, or ineligible and intolerant cohort. Serious adverse events occurred in 12 (6%) patients in the treatment-naive group; 11 (5%) non-responders, and 16 (7%) ineligible, intolerant, or ineligible and intolerant patients; adverse events leading to discontinuation (most commonly reversible increases in alanine or aspartate aminotransferase) occurred in six (3%), two (1%), and two (1%) patients, respectively, with no deaths recorded. Grade 3 or 4 laboratory abnormalities were uncommon, with low incidences of aminotransferase increases during the first 12 weeks with daclatasvir plus asunaprevir and placebo in treatment-naive patients (≤2% each). Daclatasvir plus asunaprevir provided high sustained virological response rates in treatment-naive, non-responder, and ineligible, intolerant, or ineligible and intolerant patients, and was well tolerated in patients with HCV genotype 1b infection. These results support the use of daclatasvir plus asunaprevir as an all-oral, interferon-free and ribavirin-free treatment option for patients with HCV genotype 1b infection, including those with cirrhosis. Bristol-Myers Squibb. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. 7 CFR 4280.173 - Grant funding for feasibility studies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... costs will be considered eligible. Eligible project costs for renewable energy system feasibility... America Program General Renewable Energy System Feasibility Study Grants § 4280.173 Grant funding for...; and (3) Environmental study. (c) Ineligible project costs. Ineligible project costs for renewable...

  2. 7 CFR 4280.173 - Grant funding for feasibility studies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... costs will be considered eligible. Eligible project costs for renewable energy system feasibility... America Program General Renewable Energy System Feasibility Study Grants § 4280.173 Grant funding for...; and (3) Environmental study. (c) Ineligible project costs. Ineligible project costs for renewable...

  3. 7 CFR 4280.173 - Grant funding for feasibility studies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... costs will be considered eligible. Eligible project costs for renewable energy system feasibility... America Program General Renewable Energy System Feasibility Study Grants § 4280.173 Grant funding for...; and (3) Environmental study. (c) Ineligible project costs. Ineligible project costs for renewable...

  4. 48 CFR 3009.171-8 - Ineligible contractors.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Ineligible contractors..., HOMELAND SECURITY ACQUISITION REGULATION (HSAR) ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Responsible Prospective Contractors 3009.171-8 Ineligible contractors. Any business concern determined to be ineligible...

  5. A Phase 1-2 Multi-Center Study Evaluating Axicabtagene Ciloleucel in Subjects With Refractory Aggressive Non-Hodgkin Lymphoma (ZUMA-1)

    ClinicalTrials.gov

    2018-06-18

    Refractory Diffuse Large B Cell Lymphoma; Refractory Primary Mediastinal B Cell Lymphoma; Refractory Transformed Follicular Lymphoma; Relapsed/Refractory Transplant Ineligible Diffuse Large B Cell Lymphoma; Relapsed/Refractory Transplant Ineligible Primary Mediastinal B Cell Lymphoma; Relapsed/Refractory Transplant Ineligible Transformed Follicular Lymphoma; Relapsed/Refractory Large B Cell Lymphoma Including DLBCL, PMBCL, TFL and HGBCL After Two Systemic Lines of Therapy" in Phase 2 Expanded Cohorts

  6. 7 CFR 400.683 - Administration and maintenance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... any program pursuant to this subpart. This system contains identifying information of the ineligible... ineligibility, and time period for ineligibility. (2) Information in the Ineligible Tracking System may be used... require such information in the performance of their duties in connection with any program administered...

  7. 12 CFR 615.5143 - Disposal of ineligible investments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Disposal of ineligible investments. 615.5143... AFFAIRS, LOAN POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Investment Management § 615.5143 Disposal of ineligible investments. You must dispose of an ineligible investment within 6 months unless we approve, in...

  8. 12 CFR 615.5143 - Disposal of ineligible investments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AFFAIRS, LOAN POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Investment Management § 615.5143 Disposal of ineligible investments. You must dispose of an ineligible investment within 6 months unless we approve, in... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Disposal of ineligible investments. 615.5143...

  9. 7 CFR 273.11 - Action on households with special circumstances.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... resources with the resource eligibility limits. (3) Ineligible alien. The State agency must determine the eligibility and benefit level of any remaining household members of a household containing an ineligible alien... pro rata share, of the ineligible alien's income and deductible expenses and all of the ineligible...

  10. 7 CFR 273.11 - Action on households with special circumstances.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... resources with the resource eligibility limits. (3) Ineligible alien. The State agency must determine the eligibility and benefit level of any remaining household members of a household containing an ineligible alien... pro rata share, of the ineligible alien's income and deductible expenses and all of the ineligible...

  11. 22 CFR 40.11 - Medical grounds of ineligibility.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Medical grounds of ineligibility. 40.11 Section... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Medical Grounds of Ineligibility § 40.11 Medical grounds of ineligibility. (a) Decision on eligibility based on findings of medical doctor. A...

  12. 22 CFR 40.11 - Medical grounds of ineligibility.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Medical grounds of ineligibility. 40.11 Section... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Medical Grounds of Ineligibility § 40.11 Medical grounds of ineligibility. (a) Decision on eligibility based on findings of medical doctor. A...

  13. 7 CFR 3575.25 - Ineligible loan purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... over tenants and services offered except for industrial-site infrastructure development, (b) Facilities... facilities, (d) Telephone systems, (e) Facilities which are not modest in size, design, and cost, (f) Finder...

  14. 13 CFR 120.1891 - What happens if an SISMBD is ineligible to receive an SISMBD Loan or an advance?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ineligible to receive an SISMBD Loan or an advance? 120.1891 Section 120.1891 Business Credit and Assistance... SISMBD is ineligible to receive an SISMBD Loan or an advance? If an SISMBD that has received funds from an SISMBD Loan or an advance is found to be ineligible for the loan or any advance under the loan or...

  15. Pathology analysis for mesothelioma study in the United Kingdom: Current practice and historical development.

    PubMed

    Case, B W

    2016-01-01

    Following up on the largest case-control study of malignant mesothelioma yet performed, investigators at the London School of Hygiene and Tropical Medicine assessed 1732 male and 670 female cases as of May 2013. Epidemiological findings of a subset of these were published previously, excluding patients who died or who refused to be interviewed. Pathology reports were collected for subjects, including those both eligible and ineligible for epidemiology study based on vital status. The current investigation examined 860 cases having pathology reports available. Sixty-one cases were diagnosed using cytology only, often with equivocal diagnoses, while 799 reported at least a biopsy of the tumor. Of these, 748 had pathology sufficiently detailed for evaluation. These reports were examined for basis of diagnosis, differences between study cases and ineligible cases, pathology characteristics, and immunohistochemical and other tests used. The most prominent subtype was epithelioid (64% of study cases but only 49% of ineligible cases). Biphasic subtype was present in 10% of study cases and 16% of those ineligible. Sarcomatoid subtype was present in 7% of study cases and 19% of ineligible cases, most of whom died. Twelve percent of study cases displayed no specified subtype, versus 7% of ineligible cases. Of recorded immunohistochemical stains specific for mesothelial cell origin, calretinin (95%) and CK 5/6 or CK5 alone (84%) were by far the most common. Calretinin and CK 5/6 or CK 5 alone were also most sensitive and positive in 92% of cases presenting with surgical pathology report. Ninety percent of cases had at least one immunohistochemical marker for possible lung carcinoma applied, with BER-Ep4 and TTF-1 the most frequent at 68% and CEA at 58%. TTF-1 and CEA were positive in 1% or less of cases. Patterns of use and positive and negative results for each of these as well as other immunohistochemical stains are presented and discussed, along with a brief historical description of their development and use. Possible effects of the pathologic analysis on the results of previously published and future epidemiological studies are discussed.

  16. 10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

  17. 10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

  18. 10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

  19. 10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

  20. 10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Design objectives for equipment to control releases of..., Certifications, and Regulatory Approvals; Form; Contents; Ineligibility of Certain Applicants § 50.34a Design objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a...

  1. Characteristics and Medication Use of Psoriasis Patients Who May or May Not Qualify for Randomized Controlled Trials.

    PubMed

    Malatestinic, William; Nordstrom, Beth; Wu, Jashin J; Goldblum, Orin; Solotkin, Kathleen; Lin, Chen-Yen; Kistler, Kristin; Fraeman, Kathy; Johnston, Joseph; Hawley, Lcdr Lesley; Sicignano, Nicholas; Araujo, Andre

    2017-03-01

    Clinical trials impose exclusion criteria that may limit the generalizability of results. To (a) determine the percentage of real-world patients who would qualify for psoriasis randomized controlled trials; (b) ascertain differences between moderate-to-severe psoriasis patients who would be eligible, ineligible, or potentially eligible for clinical trials; and (c) compare their biologic treatment patterns. Moderate-to-severe psoriasis patients were identified from the U.S. Department of Defense health care database from January 1, 2008, to October 31, 2013. Eligibility classification for psoriasis trials was based on common trial exclusion criteria involving medical conditions and recent treatment history. Patient characteristics and treatment patterns of 4 biologics (adalimumab, etanercept, infliximab, and ustekinumab) were compared between groups. Adherence was measured by medication possession ratio and persistence as continuous time on drug with ≤ 90-day gap between supply times. Among 16,284 qualifying psoriasis patients, 4,677 (28.7%) were medically ineligible, and 8,466 (52.0%) had ineligibility-related treatments that could be stopped prior to trial entry; the latter patients were considered potentially eligible for psoriasis trials. Common reasons for medical ineligibility included malignancies and hematologic disorders; treatment ineligibilities included use of topical corticosteroids and phototherapy. Medically ineligible patients were older and had more comorbidities, while potentially eligible patients were younger and healthier than trial-eligible patients. Most treatment patterns were similar across groups, except that, compared with the trial-eligible group, medically ineligible patients had greater adherence to infliximab and potentially trial-eligible patients had greater adherence and persistence to adalimumab. This large real-world study found that patients who may be ineligible for psoriasis trials differ in important respects (e.g., comorbidities, prior treatments) from their trial-eligible counterparts. Regardless of their differences at baseline, adherence, persistence, and switching of biologic medications are largely similar, with few differences noted among groups. Financial support for this study was provided by Lilly USA. Wu has received research funding from AbbVie, Amgen, AstraZeneca, Boehringer Ingelheim, Coherus Biosciences, Dermira, Eli Lilly, Janssen, Merck, Novartis, Pfizer, Regeneron, Sandoz, and Sun Pharmaceutical Industries, and he is a consultant for AbbVie, Amgen, Celgene, Dermira, Eli Lilly, Pfizer, Regeneron, and Sun Pharmaceutical Industries. Malatestinic, Goldblum, Solotkin, Lin, Johnston, and Araujo are employees and/or stock owners of Lilly. Nordstrom, Kistler, and Fraeman are employees of Evidera, which received funding from Lilly to conduct this study. LCDR Hawley is a military service member. This work was prepared as part of her official duties. Title 17 U.S.C. 105 provides that "copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. 101 defines a U.S. government work as a work prepared by a military service member or employee of the U.S. government as part of that person's official duties. Research data were derived from an approved Naval Medical Center, Portsmouth, Virginia, institutional review board protocol. The views expressed in this work are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the U.S. government. Study concept and design were contributed by Malatestinic and Araujo, along with the other authors. Nordstrom, Kistler, Fraeman, and Sicignano collected the data, and data interpretation was performed by Wu, Lin, and Hawley, along with Malatestinic, Nordstrom, Solotkin, and Araujo. The manuscript was written by Johnston, Malatestinic, Kistler, Wu, and Araujo, along with Nordstrom, Goldblum, Solotkin, Hawley, and Sicignano, and revised by Goldblum, Solotkin, Malatestinic, and Araujo, along with Nordstrom, Wu, Fraeman, Johnston, Hawley, and Sicignano.

  2. 77 FR 7579 - Debarment, Suspension, and Ineligibility of Contractors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... GOVERNMENT ACCOUNTABILITY OFFICE Debarment, Suspension, and Ineligibility of Contractors AGENCY... government contractors. Comments on GAO's policy were due on or before November 14, 2011. GAO received two... debarment, suspension, and ineligibility of government contractors. Neither comment suggested any changes to...

  3. 78 FR 12106 - Debarment, Suspension, and Ineligibility of Contractors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... OFFICE OF PERSONNEL MANAGEMENT Debarment, Suspension, and Ineligibility of Contractors AGENCY: U.S... Acquisition Regulation (FAR) regarding the debarment, suspension, and ineligibility of government contractors... ensure that it contracts only with those entities and individuals (hereinafter, contractors) who are...

  4. 41 CFR 60-741.68 - Reinstatement of ineligible contractors.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ineligible contractors. 60-741.68 Section 60-741.68 Public Contracts and Property Management Other Provisions..., DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... Reinstatement of ineligible contractors. (a) Application for reinstatement. A contractor debarred from further...

  5. 41 CFR 60-300.68 - Reinstatement of ineligible contractors.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ineligible contractors. 60-300.68 Section 60-300.68 Public Contracts and Property Management Other Provisions..., DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... ineligible contractors. (a) Application for reinstatement. A contractor debarred from further contracts for...

  6. 41 CFR 60-250.68 - Reinstatement of ineligible contractors.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ineligible contractors. 60-250.68 Section 60-250.68 Public Contracts and Property Management Other Provisions..., DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... ineligible contractors. (a) Application for reinstatement. A contractor debarred from further contracts for...

  7. 7 CFR 1484.51 - What are ineligible contributions?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false What are ineligible contributions? 1484.51 Section 1484.51 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT... AGRICULTURAL COMMODITIES Contributions and Reimbursements § 1484.51 What are ineligible contributions? (a) The...

  8. 7 CFR 1779.25 - Ineligible loan purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Ineligible loan purposes. 1779.25 Section 1779.25 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.25 Ineligible loan purposes...

  9. 7 CFR 4288.12 - Ineligible project costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Ineligible project costs. 4288.12 Section 4288.12 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND... Eligible Biorefineries § 4288.12 Ineligible project costs. Any project costs incurred by the applicant...

  10. 7 CFR 4288.12 - Ineligible project costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Ineligible project costs. 4288.12 Section 4288.12 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND... Eligible Biorefineries § 4288.12 Ineligible project costs. Any project costs incurred by the applicant...

  11. 7 CFR 4288.12 - Ineligible project costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Ineligible project costs. 4288.12 Section 4288.12 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND... Eligible Biorefineries § 4288.12 Ineligible project costs. Any project costs incurred by the applicant...

  12. 41 CFR 60-1.31 - Reinstatement of ineligible contractors.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ineligible contractors. 60-1.31 Section 60-1.31 Public Contracts and Property Management Other Provisions..., DEPARTMENT OF LABOR 1-OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS General Enforcement; Compliance Review and Complaint Procedure § 60-1.31 Reinstatement of ineligible contractors. A contractor debarred from...

  13. 7 CFR 1486.402 - What are ineligible contributions?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false What are ineligible contributions? 1486.402 Section 1486.402 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT... Reimbursements § 1486.402 What are ineligible contributions? (a) The following are not eligible as contributions...

  14. Socioeconomic and Gender Group Differences in Early Literacy Skills: A Multiple-Group Confirmatory Factor Analysis Approach

    ERIC Educational Resources Information Center

    Lee, Julia Ai Cheng; Al Otaiba, Stephanie

    2015-01-01

    Socioeconomic status and gender are important demographic variables that strongly relate to academic achievement. This study examined the early literacy skills differences between 4 sociodemographic groups, namely, boys ineligible for free or reduced-price lunch (FRL), girls ineligible for FRL, boys eligible for FRL, and girls eligible for FRL.…

  15. 12 CFR 1261.13 - Ineligible Bank directors.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Ineligible Bank directors. 1261.13 Section 1261.13 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS FEDERAL HOME LOAN BANK DIRECTORS Federal Home Loan Bank Boards of Directors: Eligibility and Elections § 1261.13 Ineligible Bank...

  16. 12 CFR 1261.13 - Ineligible Bank directors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Ineligible Bank directors. 1261.13 Section 1261.13 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS FEDERAL HOME LOAN BANK DIRECTORS Federal Home Loan Bank Boards of Directors: Eligibility and Elections § 1261.13 Ineligible Bank...

  17. 7 CFR 1956.112 - Debts ineligible for settlement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Debts ineligible for settlement. 1956.112 Section 1956.112 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... § 1956.112 Debts ineligible for settlement. Debts will not be settled: (a) If referral to the Office of...

  18. 7 CFR 1486.202 - Are there any ineligible entities?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Are there any ineligible entities? 1486.202 Section... Eligibility, Applications, and Funding § 1486.202 Are there any ineligible entities? Foreign organizations, whether government or private, may participate as third parties in activities carried out by U.S. entities...

  19. 7 CFR 1486.202 - Are there any ineligible entities?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Are there any ineligible entities? 1486.202 Section... Eligibility, Applications, and Funding § 1486.202 Are there any ineligible entities? Foreign organizations, whether government or private, may participate as third parties in activities carried out by U.S. entities...

  20. 76 FR 19752 - List of Institutions of Higher Education Ineligible for Federal Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... DEPARTMENT OF DEFENSE Office of the Secretary List of Institutions of Higher Education Ineligible... to identify institutions of higher education that are ineligible for contracts and grants by reason.... The institutions of higher education so identified are: Vermont Law School, South Royalton, Vermont...

  1. 75 FR 48953 - List of Institutions of Higher Education Ineligible for Federal Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... DEPARTMENT OF DEFENSE Office of the Secretary List of Institutions of Higher Education Ineligible... published to identify institutions of higher education that are ineligible for contracts and grants by... part 216. The institutions of higher education so identified are the Vermont Law School, South Royalton...

  2. 75 FR 6359 - List of Institutions of Higher Education Ineligible for Federal Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... DEPARTMENT OF DEFENSE Office of the Secretary List of Institutions of Higher Education Ineligible... published to identify institutions of higher education that are ineligible for contracts and grants by... part 216. The institutions of higher education so identified are: Vermont Law School, South Royalton...

  3. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  4. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  5. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  6. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  7. 8 CFR 245a.32 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 245a.32 Section 245a.32 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS TO... IMMIGRATION AND NATIONALITY ACT LIFE Act Amendments Family Unity Provisions § 245a.32 Ineligible aliens. The...

  8. 15 CFR 2301.7 - Eligible and ineligible project costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Eligible and ineligible project costs... TELECOMMUNICATIONS FACILITIES PROGRAM Application Requirements § 2301.7 Eligible and ineligible project costs. (a... wherever the two types of apparatus interface. (c) Total project costs do not include the value of eligible...

  9. 15 CFR 2301.7 - Eligible and ineligible project costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Eligible and ineligible project costs... TELECOMMUNICATIONS FACILITIES PROGRAM Application Requirements § 2301.7 Eligible and ineligible project costs. (a... wherever the two types of apparatus interface. (c) Total project costs do not include the value of eligible...

  10. 15 CFR 2301.7 - Eligible and ineligible project costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Eligible and ineligible project costs... TELECOMMUNICATIONS FACILITIES PROGRAM Application Requirements § 2301.7 Eligible and ineligible project costs. (a... wherever the two types of apparatus interface. (c) Total project costs do not include the value of eligible...

  11. 15 CFR 2301.7 - Eligible and ineligible project costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Eligible and ineligible project costs... TELECOMMUNICATIONS FACILITIES PROGRAM Application Requirements § 2301.7 Eligible and ineligible project costs. (a... wherever the two types of apparatus interface. (c) Total project costs do not include the value of eligible...

  12. 15 CFR 2301.7 - Eligible and ineligible project costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Eligible and ineligible project costs... TELECOMMUNICATIONS FACILITIES PROGRAM Application Requirements § 2301.7 Eligible and ineligible project costs. (a... wherever the two types of apparatus interface. (c) Total project costs do not include the value of eligible...

  13. 5 CFR 575.104 - Ineligible categories of employees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INCENTIVES Recruitment Incentives § 575.104 Ineligible categories of employees. An agency may not pay a recruitment incentive to an employee in— (a) A position to which an individual is appointed by the President... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Ineligible categories of employees. 575...

  14. 10 CFR 76.22 - Ineligibility of certain applicants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Ineligibility of certain applicants. 76.22 Section 76.22 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.22 Ineligibility of certain applicants. A certificate of compliance may not be issued to the...

  15. 10 CFR 76.22 - Ineligibility of certain applicants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Ineligibility of certain applicants. 76.22 Section 76.22 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.22 Ineligibility of certain applicants. A certificate of compliance may not be issued to the...

  16. 10 CFR 76.22 - Ineligibility of certain applicants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Ineligibility of certain applicants. 76.22 Section 76.22 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.22 Ineligibility of certain applicants. A certificate of compliance may not be issued to the...

  17. 10 CFR 76.22 - Ineligibility of certain applicants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Ineligibility of certain applicants. 76.22 Section 76.22 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.22 Ineligibility of certain applicants. A certificate of compliance may not be issued to the...

  18. 10 CFR 76.22 - Ineligibility of certain applicants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Ineligibility of certain applicants. 76.22 Section 76.22 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) CERTIFICATION OF GASEOUS DIFFUSION PLANTS General Provisions § 76.22 Ineligibility of certain applicants. A certificate of compliance may not be issued to the...

  19. 20 CFR 416.1202 - Deeming of resources.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... unspent portion of any retroactive payment of family separation allowance an ineligible parent (or... retroactive payment of family separation allowance an ineligible spouse received from one of the uniformed... her ineligible parent who is living in the same household with him or her (as described in § 416.1851...

  20. 13 CFR 120.884 - Ineligible costs for 504 loans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Ineligible costs for 504 loans. 120.884 Section 120.884 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.884 Ineligible costs...

  1. 13 CFR 120.884 - Ineligible costs for 504 loans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Ineligible costs for 504 loans. 120.884 Section 120.884 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.884 Ineligible costs...

  2. 13 CFR 120.881 - Ineligible Projects for 504 loans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Ineligible Projects for 504 loans. 120.881 Section 120.881 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.881 Ineligible...

  3. 13 CFR 120.881 - Ineligible Projects for 504 loans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Ineligible Projects for 504 loans. 120.881 Section 120.881 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.881 Ineligible...

  4. 13 CFR 120.881 - Ineligible Projects for 504 loans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Ineligible Projects for 504 loans. 120.881 Section 120.881 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.881 Ineligible...

  5. 13 CFR 120.884 - Ineligible costs for 504 loans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Ineligible costs for 504 loans. 120.884 Section 120.884 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.884 Ineligible costs...

  6. 13 CFR 120.881 - Ineligible Projects for 504 loans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Ineligible Projects for 504 loans. 120.881 Section 120.881 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.881 Ineligible...

  7. 13 CFR 120.881 - Ineligible Projects for 504 loans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Ineligible Projects for 504 loans. 120.881 Section 120.881 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.881 Ineligible...

  8. 13 CFR 120.884 - Ineligible costs for 504 loans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Ineligible costs for 504 loans. 120.884 Section 120.884 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Loan-Making Policies Specific to 504 Loans § 120.884 Ineligible costs...

  9. 13 CFR 123.502 - Under what circumstances is your business ineligible to be considered for a Military Reservist...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... business ineligible to be considered for a Military Reservist Economic Injury Disaster Loan? 123.502... Military Reservist Economic Injury Disaster Loans § 123.502 Under what circumstances is your business ineligible to be considered for a Military Reservist Economic Injury Disaster Loan? Your business is...

  10. 7 CFR 25.621 - Ineligible grant purposes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Ineligible grant purposes. 25.621 Section 25.621 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.621 Ineligible grant purposes. Grant funds may not be used: (a) As a source...

  11. 7 CFR 25.621 - Ineligible grant purposes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Ineligible grant purposes. 25.621 Section 25.621 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.621 Ineligible grant purposes. Grant funds may not be used: (a) As a source...

  12. 7 CFR 25.621 - Ineligible grant purposes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Ineligible grant purposes. 25.621 Section 25.621 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.621 Ineligible grant purposes. Grant funds may not be used: (a) As a source...

  13. 7 CFR 25.621 - Ineligible grant purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Ineligible grant purposes. 25.621 Section 25.621 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.621 Ineligible grant purposes. Grant funds may not be used: (a) As a source...

  14. 20 CFR 416.1264 - Spouse ineligible under a State plan in December 1973.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Spouse ineligible under a State plan in December 1973. 416.1264 Section 416.1264 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Resources and Exclusions § 416.1264 Spouse ineligible...

  15. 7 CFR 25.621 - Ineligible grant purposes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Ineligible grant purposes. 25.621 Section 25.621 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and Round IIS Grants § 25.621 Ineligible grant purposes. Grant funds may not be used: (a) As a source...

  16. Recruitment of adolescents for a smoking study: use of traditional strategies and social media.

    PubMed

    Rait, Michelle A; Prochaska, Judith J; Rubinstein, Mark L

    2015-09-01

    Engaging and retaining adolescents in research studies is challenging. Social media offers utility for expanding the sphere of research recruitment. This study examined and compared traditional and Facebook-based recruitment strategies on reach, enrollment, cost, and retention. Substance users aged 13-17 years were recruited through several methods, including social media, a study website, fliers, talks in schools, bus ads, and referrals. Study involvement included a one-time visit and semiannual follow-up surveys. 1265 individuals contacted study personnel; 629 were ineligible; 129 declined; and 200 participants enrolled. Facebook drew the greatest volume but had a high rate of ineligibles. Referrals were the most successful and cost-effective ($7 per enrolled participant); school talks were the least. Recruitment source was unrelated to retention success. Facebook may expand recruitment reach, but had greater financial costs and more ineligible contacts, resulting in fewer enrollees relative to traditional interpersonal recruitment methods. Referrals, though useful for study engagement, did not provide a differential benefit in terms of long-term retention.

  17. 34 CFR 668.139 - Recovery of payments and loan disbursements to ineligible students.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ineligible students. (a) If an institution makes a payment of a grant or a disbursement of a Federal Perkins... (2) Making a reasonable effort to collect the payment or Federal Perkins loan. (b) If an institution... an institution is liable for a payment of a grant or Federal Perkins loan to an ineligible student...

  18. 34 CFR 668.139 - Recovery of payments and loan disbursements to ineligible students.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ineligible students. (a) If an institution makes a payment of a grant or a disbursement of a Federal Perkins... (2) Making a reasonable effort to collect the payment or Federal Perkins loan. (b) If an institution... an institution is liable for a payment of a grant or Federal Perkins loan to an ineligible student...

  19. 24 CFR 1000.44 - What prohibitions on the use of debarred, suspended, or ineligible contractors apply?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false What prohibitions on the use of debarred, suspended, or ineligible contractors apply? 1000.44 Section 1000.44 Housing and Urban Development... § 1000.44 What prohibitions on the use of debarred, suspended, or ineligible contractors apply? In...

  20. 24 CFR 266.205 - Ineligible projects.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... designed for the elderly with extensive services and luxury accommodations that provide for central kitchens and dining rooms with food service or mandatory services. (d) Nursing homes or intermediate care facilities. Nursing homes and intermediate care facilities licensed and regulated by State or local...

  1. 24 CFR 266.205 - Ineligible projects.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... designed for the elderly with extensive services and luxury accommodations that provide for central kitchens and dining rooms with food service or mandatory services. (d) Nursing homes or intermediate care facilities. Nursing homes and intermediate care facilities licensed and regulated by State or local...

  2. 24 CFR 266.205 - Ineligible projects.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... designed for the elderly with extensive services and luxury accommodations that provide for central kitchens and dining rooms with food service or mandatory services. (d) Nursing homes or intermediate care facilities. Nursing homes and intermediate care facilities licensed and regulated by State or local...

  3. 24 CFR 266.205 - Ineligible projects.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... designed for the elderly with extensive services and luxury accommodations that provide for central kitchens and dining rooms with food service or mandatory services. (d) Nursing homes or intermediate care facilities. Nursing homes and intermediate care facilities licensed and regulated by State or local...

  4. 24 CFR 266.205 - Ineligible projects.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... designed for the elderly with extensive services and luxury accommodations that provide for central kitchens and dining rooms with food service or mandatory services. (d) Nursing homes or intermediate care facilities. Nursing homes and intermediate care facilities licensed and regulated by State or local...

  5. 48 CFR 252.245-7004 - Reporting, Reutilization, and Disposal.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., and Disposal. 252.245-7004 Section 252.245-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT.... Government under surplus sales contracts; (iii) Designated by the Department of Defense as ineligible...

  6. 48 CFR 252.245-7004 - Reporting, Reutilization, and Disposal.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., and Disposal. 252.245-7004 Section 252.245-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... surplus sales contracts; (iii) Designated by the Department of Defense as ineligible, debarred, or...

  7. 48 CFR 252.245-7004 - Reporting, Reutilization, and Disposal.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., and Disposal. 252.245-7004 Section 252.245-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT.... Government under surplus sales contracts; (iii) Designated by the Department of Defense as ineligible...

  8. 48 CFR 252.245-7004 - Reporting, Reutilization, and Disposal.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., and Disposal. 252.245-7004 Section 252.245-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... surplus sales contracts; (iii) Designated by the Department of Defense as ineligible, debarred, or...

  9. 75 FR 82242 - Visas: Waiver for Ineligible Nonimmigrants Under the Immigration and Nationality Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-30

    ... against a waiver for an alien who is ineligible for a nonimmigrant visa under INA 212(a)(3)(E) with a bar against a waiver for an alien who is ineligible for a nonimmigrant visa under clauses (i) or (ii) of INA... economic impact on a substantial number of small entities. This regulates individual aliens who are...

  10. 42 CFR 435.135 - Individuals who become ineligible for cash assistance as a result of OASDI cost-of-living...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Individuals who become ineligible for cash assistance as a result of OASDI cost-of-living increases received after April 1977. 435.135 Section 435.135..., Blind, and Disabled § 435.135 Individuals who become ineligible for cash assistance as a result of OASDI...

  11. 40 CFR 35.4025 - Is there any way my group can get a TAG if it is currently ineligible?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Is there any way my group can get a TAG if it is currently ineligible? 35.4025 Section 35.4025 Protection of Environment ENVIRONMENTAL... Assistance Who Is Eligible? § 35.4025 Is there any way my group can get a TAG if it is currently ineligible...

  12. Olfactory Deficits in MCI as Predictor of Improved Cognition on Donepezil

    DTIC Science & Technology

    2013-04-01

    date. Of the 14 who were ineligible, 8 were ineligible because they were already on cholinesterate inhibitors or memantine (2 subjects were on... memantine and donepezil; 2 subjects were on memantine and rivastigmine; 1 subject was on memantine ; 3 subjects were on donepezil). 5 As noted...above, many of the subjects were not eligible for the study because they were already on chlolinesterase inhibitors or memantine , prescribed by their

  13. 24 CFR 983.53 - Prohibition of assistance for ineligible units.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... grounds of a penal, reformatory, medical, mental, or similar public or private institution; (3) Nursing... facility that provides home health care services such as nursing and therapy for residents of the housing... designated for occupancy by students of the institution; (5) Manufactured homes; (6) Cooperative housing; and...

  14. Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials.

    PubMed

    Mount, David L; Feeney, Patricia; Fabricatore, Anthony N; Coday, Mace; Bahnson, Judy; Byington, Robert; Phelan, Suzanne; Wilmoth, Sharon; Knowler, William C; Hramiak, Irene; Osei, Kwame; Sweeney, Mary Ellen; Espeland, Mark A

    2009-10-01

    Comparing findings from separate trials is necessary to choose among treatment options, however differences among study cohorts may impede these comparisons. As a case study, to examine the overlap of study cohorts in two large randomized controlled clinical trials that assess interventions to reduce risk of major cardiovascular disease events in adults with type 2 diabetes in order to explore the feasibility of cross-trial comparisons The Action for Health in Diabetes (Look AHEAD) and The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trials enrolled 5145 and 10,251 adults with type 2 diabetes, respectively. Look AHEAD assesses the efficacy of an intensive lifestyle intervention designed to produce weight loss; ACCORD tests pharmacological therapies for control of glycemia, hyperlipidemia, and hypertension. Incidence of major cardiovascular disease events is the primary outcome for both trials. A sample was constructed to include participants from each trial who appeared to meet eligibility criteria and be appropriate candidates for the other trial's interventions. Demographic characteristics, health status, and outcomes of members and nonmembers of this constructed sample were compared. Nearly 80% of Look AHEAD participants were projected to be ineligible for ACCORD; ineligibility was primarily due to better glycemic control or no early history of cardiovascular disease. Approximately 30% of ACCORD participants were projected to be ineligible for Look AHEAD, often for reasons linked to poorer health. The characteristics of participants projected to be jointly eligible for both trials continued to reflect differences between trials according to factors likely linked to retention, adherence, and study outcomes. Accurate ascertainment of cross-trial eligibility was hampered by differences between protocols. Despite several similarities, the Look AHEAD and ACCORD cohorts represent distinct populations. Even within the subsets of participants who appear to be eligible and appropriate candidates for trials of both modes of intervention, differences remained. Direct comparisons of results from separate trials of lifestyle and pharmacologic interventions are compromised by marked differences in enrolled cohorts.

  15. 78 FR 42823 - Patient Protection and Affordable Care Act; Exchange Functions: Standards for Navigators and Non...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ...This final rule addresses various requirements applicable to Navigators and non-Navigator assistance personnel in Federally- facilitated Exchanges, including State Partnership Exchanges, and to non-Navigator assistance personnel in State Exchanges that are funded through federal Exchange Establishment grants. It finalizes the requirement that Exchanges must have a certified application counselor program. It creates conflict-of-interest, training and certification, and meaningful access standards; clarifies that any licensing, certification, or other standards prescribed by a state or Exchange must not prevent application of the provisions of title I of the Affordable Care Act; adds entities with relationships to issuers of stop loss insurance to the list of entities that are ineligible to become Navigators; and clarifies that the same ineligibility criteria that apply to Navigators apply to certain non-Navigator assistance personnel. The final rule also directs that each Exchange designate organizations which will then certify their staff members and volunteers to be application counselors that assist consumers and facilitate enrollment in qualified health plans and insurance affordability programs, and provides standards for that designation.

  16. 22 CFR 40.11 - Medical grounds of ineligibility.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Medical Grounds of Ineligibility § 40.11...). If an immigrant visa applicant is inadmissible under INA 212(a)(1)(A)(i), (ii), or (iii) but is...

  17. Factors Associated With Ineligibility for PCI Differ Between Inpatient and Outpatient ST-Elevation Myocardial Infarction.

    PubMed

    Jaski, Brian E; Grigoriadis, Christopher E; Dai, Xuming; Meredith, Richard D; Ortiz, Bryan C; Stouffer, George A; Thomas, Lorie; Smith, Sidney C

    2016-08-01

    Without early revascularization, both inpatient and outpatient STEMIs have poor outcomes. Reasons for denying PCI for STEMI, however, remain uncertain. This single-center retrospective cohort study compares factors and outcomes associated with ineligibility for PCI between inpatients and outpatients following ST-elevation myocardial infarction (STEMI). A total of 1,759 STEMI patients between June 2009 and January 2015 were assessed. Individual medical records were reviewed to obtain reasons for PCI ineligibility for STEMI patients who did not receive reperfusion therapy. Compared to outpatients with STEMI (n = 1,688), inpatients (n = 71) were less likely to receive coronary angiography (60.6% vs 95.9%; P < 0.001) or PCI (50.7% vs 80.9%; P < 0.001), with longer ECG/door to first device activation times (97 [78, 131] vs 63 [49, 78] minutes; P < 0.001). When coronary angiography was performed, however, similar rates of PCI and procedural success were seen in both groups. Principal contraindication for PCI was risk of bleeding within the inpatient population and complex coronary artery disease within the outpatient population. Total in-hospital mortality was higher in inpatient STEMIs compared to outpatients (42.2% vs 10.0%; P < 0.001), but lower for patients eligible for PCI in both groups. Reasons for PCI ineligibility differ between inpatient and outpatient STEMIs. Inpatients have increased risks of bleeding, lower coronary angiography and PCI use, and higher in-hospital mortality. Especially for inpatients, specific PCI STEMI protocols that anticipate and overcome types of ineligibility and delay for cardiac catheterization may improve outcomes. © 2016, Wiley Periodicals, Inc.

  18. Cream of the Crop: Clinical Representativeness of Eligible and Ineligible Cannabis Users in Research.

    PubMed

    Rosen, Alexis S; Sodos, Louise M; Hirst, Rayna B; Vaughn, Dylan; Lorkiewicz, Sara A

    2018-03-06

    Experts have recommended criteria (Gonzalez et al., 2002) for recruiting pure chronic cannabis users (i.e., those without polysubstance use or psychiatric illness) when evaluating cannabis' non-acute effects on cognition. We sought to demonstrate the implications of using such criteria by examining characteristics of respondents who completed an eligibility screening for a parent study evaluating the cognitive effects of chronic cannabis use. Over a 3-year, 8-month period, 612 respondents from the community completed an eligibility screening based on recommendations in the cannabis literature. Using independent samples t-tests and chi-square tests, we examined whether qualified/eligible respondents (n = 219) differed from non-qualified/ineligible respondents (n = 393). Compared to ineligible cannabis users, eligible cannabis-using respondents were significantly younger, used cannabis more frequently, used alcohol less frequently, and were less likely to have a history of other drug use, a psychiatric diagnosis, or to have used psychiatric medication. Conclusions/Importance: Our findings indicate that eligible/pure cannabis users are not representative of typical cannabis users in the general community (i.e., ineligible users with polysubstance use and/or psychiatric diagnoses) who ultimately comprised the majority of our cannabis-using sample (65.2%). Thus, typical cannabis users may be more accurately characterized as polysubstance users, posing a number of challenges related to the generalizability of findings from studies utilizing pure samples of cannabis users. Recruiting samples of typical cannabis users will improve external validity in research. Furthermore, reporting comprehensive characteristics of such samples will enable consumers to gauge the applicability of study findings to populations of interest.

  19. High early event rates in patients with questionable eligibility for advanced heart failure therapies: Results from the Medical Arm of Mechanically Assisted Circulatory Support (Medamacs) Registry.

    PubMed

    Ambardekar, Amrut V; Forde-McLean, Rhondalyn C; Kittleson, Michelle M; Stewart, Garrick C; Palardy, Maryse; Thibodeau, Jennifer T; DeVore, Adam D; Mountis, Maria M; Cadaret, Linda; Teuteberg, Jeffrey J; Pamboukian, Salpy V; Cantor, Ryan S; Lindenfeld, JoAnn

    2016-06-01

    The prognosis of ambulatory patients with advanced heart failure (HF) who are not yet inotrope dependent and implications for evaluation and timing for transplant or destination therapy with a left ventricular assist device (DT-LVAD) are unknown. We hypothesized that the characteristics defining eligibility for advanced HF therapies would be a primary determinant of outcomes in these patients. Ambulatory patients with advanced HF (New York Heart Association class III-IV, Interagency Registry for Mechanically Assisted Circulatory Support profiles 4-7) were enrolled across 11 centers from May 2013 to February 2015. Patients were stratified into 3 groups: likely transplant eligible, DT-LVAD eligible, and ineligible for both transplant and DT-LVAD. Clinical characteristics were collected, and patients were prospectively followed for death, transplant, and left ventricular assist device implantation. The study enrolled 144 patients with a mean follow-up of 10 ± 6 months. Patients in the ineligible cohort (n = 43) had worse congestion, renal function, and anemia compared with transplant (n = 51) and DT-LVAD (n = 50) eligible patients. Ineligible patients had higher mortality (23.3% vs 8.0% in DT-LVAD group and 5.9% in transplant group, p = 0.02). The differences in mortality were related to lower rates of transplantation (11.8% in transplant group vs 2.0% in DT-LVAD group and 0% in ineligible group, p = 0.02) and left ventricular assist device implantation (15.7% in transplant group vs 2.0% in DT-LVAD group and 0% in ineligible group, p < 0.01). Ambulatory patients with advanced HF who were deemed ineligible for transplant and DT-LVAD had markers of greater HF severity and a higher rate of mortality compared with patients eligible for transplant or DT-LVAD. The high early event rate in this group emphasizes the need for timely evaluation and decision making regarding lifesaving therapies. Copyright © 2016 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

  20. Design, recruitment outcomes, and sample characteristics of the Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) trial.

    PubMed

    Krebs, Erin E; Jensen, Agnes C; Nugent, Sean; DeRonne, Beth; Rutks, Indulis; Leverty, David; Gravely, Amy; Noorbaloochi, Siamak; Bair, Matthew J; Kroenke, Kurt

    2017-11-01

    This manuscript describes the study protocol, recruitment outcomes, and baseline participant characteristics for the Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) trial. SPACE is a pragmatic randomized comparative effectiveness trial conducted in multiple VA primary care clinics within one VA health care system. The objective was to compare benefits and harms of opioid therapy versus non-opioid medication therapy over 12months among patients with moderate-to-severe chronic back pain or hip/knee osteoarthritis pain despite analgesic therapy; patients already receiving regular opioid therapy were excluded. Key design features include comparing two clinically-relevant medication interventions, pragmatic eligibility criteria, and flexible treat-to-target interventions. Screening, recruitment and study enrollment were conducted over 31months. A total of 4491 patients were contacted for eligibility screening; 53.1% were ineligible, 41.0% refused, and 5.9% enrolled. The most common reasons for ineligibility were not meeting pain location and severity criteria. The most common study-specific reasons for refusal were preference for no opioid use and preference for no pain medications. Of 265 enrolled patients, 25 withdrew before randomization. Of 240 randomized patients, 87.9% were male, 84.1% were white, and age range was 21-80years. Past-year mental health diagnoses were 28.3% depression, 17% anxiety, 9.4% PTSD, 7.9% alcohol use disorder, and 2.6% drug use disorder. In conclusion, although recruitment for this trial was challenging, characteristics of enrolled participants suggest we were successful in recruiting patients similar to those prescribed opioid therapy in usual care. Published by Elsevier Inc.

  1. Observational methods to assess the effectiveness of screening colonoscopy in reducing right colon cancer mortality risk: SCOLAR.

    PubMed

    Goodman, Michael; Fletcher, Robert H; Doria-Rose, V Paul; Jensen, Christopher D; Zebrowski, Alexis M; Becerra, Tracy A; Quinn, Virginia P; Zauber, Ann G; Corley, Douglas A; Doubeni, Chyke A

    2015-11-01

    Screening colonoscopy's effectiveness in reducing risk of death from right colon cancers remains unclear. Methodological challenges of existing observational studies addressing this issue motivated the design of 'Effectiveness of Screening for Colorectal Cancer in Average-Risk Adults (SCOLAR)'. SCOLAR is a nested case-control study based on two large integrated health systems. This affords access to a large, well-defined historical cohort linked to integrated data on cancer outcomes, patient eligibility, test indications and important confounders. We found electronic data adequate for excluding ineligible patients (except family history), but not the detailed information needed for test indication assignment. The lessons of SCOLAR's design and implementation may be useful for future studies seeking to evaluate the effectiveness of screening tests in community settings.

  2. 7 CFR 1740.7 - Ineligible purposes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Ineligible purposes. 1740.7 Section 1740.7 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PUBLIC TELEVISION STATION DIGITAL TRANSITION GRANT PROGRAM Public Television Station Digital...

  3. 7 CFR 1740.7 - Ineligible purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Ineligible purposes. 1740.7 Section 1740.7 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PUBLIC TELEVISION STATION DIGITAL TRANSITION GRANT PROGRAM Public Television Station Digital...

  4. 76 FR 60838 - Debarment, Suspension, and Ineligibility of Contractors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... GOVERNMENT ACCOUNTABILITY OFFICE Debarment, Suspension, and Ineligibility of Contractors AGENCY... of government contractors. As a legislative branch agency, GAO is not subject to the requirements of... (hereinafter, contractors) who are responsible. However, GAO's Procurement Order has not explicitly referenced...

  5. 48 CFR 1609.470 - Notification of Debarment, Suspension, and Ineligibility.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Notification of Debarment, Suspension, and Ineligibility. 1609.470 Section 1609.470 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION ACQUISITION PLANNING...

  6. 48 CFR 1609.470 - Notification of Debarment, Suspension, and Ineligibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Notification of Debarment, Suspension, and Ineligibility. 1609.470 Section 1609.470 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION ACQUISITION PLANNING...

  7. 48 CFR 1609.470 - Notification of Debarment, Suspension, and Ineligibility.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Notification of Debarment, Suspension, and Ineligibility. 1609.470 Section 1609.470 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION ACQUISITION PLANNING...

  8. 48 CFR 1609.470 - Notification of Debarment, Suspension, and Ineligibility.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Notification of Debarment, Suspension, and Ineligibility. 1609.470 Section 1609.470 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION ACQUISITION PLANNING...

  9. 20 CFR 404.1208 - Ineligible employees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Ineligible employees. 404.1208 Section 404.1208 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Coverage of Employees of State and Local Governments What Groups of Employees May Be...

  10. 22 CFR 228.36 - Ineligible suppliers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Ineligible suppliers. 228.36 Section 228.36 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES ON SOURCE, ORIGIN AND NATIONALITY FOR... services. The limited exceptions to this rule are: (a) Individuals lawfully admitted for permanent...

  11. 24 CFR 570.207 - Ineligible activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Ineligible activities. 570.207 Section 570.207 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  12. 24 CFR 570.207 - Ineligible activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Ineligible activities. 570.207 Section 570.207 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND...

  13. Reasons for HCV non-treatment in underserved African Americans: implications for treatment with new therapeutics.

    PubMed

    Schaeffer, Sarah; Khalili, Mandana

    2015-01-01

    African Americans are disproportionately affected by hepatitis C (HCV) and are less likely to undergo HCV treatment. Underserved populations are especially at risk for experiencing health disparity. Aim. To identify reasons for HCV non-treatment among underserved African Americans in a large safetynet system. Medical records of HCV-infected African Americans evaluated at San Francisco General Hospital liver specialty clinic from 2006-2011 who did not receive HCV treatment were reviewed. Treatment eligibility and reasons for non-treatment were assessed. Factors associated with treatment ineligibility were assessed using logistic regression modeling. Among 118 patients, 42% were treatment ineligible, 18% treatment eligible, and 40% were undergoing work-up to determine eligibility. Reasons for treatment ineligibility were medical (54%), non-medical (14%), psychiatric (4%), or combined (28%). When controlling for age and sex, active/recent substance abuse (OR 6.65, p = 0.001) and having two or more medical comorbidities (OR 3.39, p = 0.005) predicted treatment ineligibility. Excluding those ineligible for treatment, 72% of all other patients were lost to follow-up; they were older (55 vs. 48 years, p = 0.01) and more likely to be undergoing work up to determine treatment eligibility (86 vs. 21%, p < 0.0001) than those not lost to follow-up. Medical comorbidities and substance abuse predicted HCV treatment ineligibility in underserved African Americans. Importantly, the majority of those undergoing work-up to determine HCV treatment eligibility were lost to follow-up. While newer anti-HCV agents may increase treatment eligibility, culturally appropriate interventions to increase compliance with evaluation and care remain critical to HCV management in underserved African Americans.

  14. Patient Protection and Affordable Care Act; Exchange functions: standards for Navigators and non-Navigator assistance personnel; consumer assistance tools and programs of an Exchange and certified application counselors. Final rule.

    PubMed

    2013-07-17

    This final rule addresses various requirements applicable to Navigators and non-Navigator assistance personnel in Federally-facilitated Exchanges, including State Partnership Exchanges, and to non-Navigator assistance personnel in State Exchanges that are funded through federal Exchange Establishment grants. It finalizes the requirement that Exchanges must have a certified application counselor program. It creates conflict-of-interest, training and certification, and meaningful access standards; clarifies that any licensing, certification, or other standards prescribed by a state or Exchange must not prevent application of the provisions of title I of the Affordable Care Act; adds entities with relationships to issuers of stop loss insurance to the list of entities that are ineligible to become Navigators; and clarifies that the same ineligibility criteria that apply to Navigators apply to certain non-Navigator assistance personnel. The final rule also directs that each Exchange designate organizations which will then certify their staff members and volunteers to be application counselors that assist consumers and facilitate enrollment in qualified health plans and insurance affordability programs, and provides standards for that designation.

  15. 24 CFR 107.60 - Sanctions and penalties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... withdrawal of approval; or a determination of ineligibility, suspension, or debarment from any further assistance or contracts; provided, however, that sanctions of debarment, suspension, and ineligibility are... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Sanctions and penalties. 107.60...

  16. 7 CFR 4288.112 - Eligibility notifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program... number. (b) Ineligibility notifications. If an applicant or a biofuel is determined by the Agency to be... application, as to the reason(s) the applicant or biofuel was determined to be ineligible. Such applicant will...

  17. 7 CFR 4288.112 - Eligibility notifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program... number. (b) Ineligibility notifications. If an applicant or a biofuel is determined by the Agency to be... application, as to the reason(s) the applicant or biofuel was determined to be ineligible. Such applicant will...

  18. 12 CFR 652.45 - Divestiture of ineligible non-program investments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... investments. 652.45 Section 652.45 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM FEDERAL AGRICULTURAL MORTGAGE CORPORATION FUNDING AND FISCAL AFFAIRS Investment Management § 652.45 Divestiture of ineligible non-program investments. (a) Divestiture requirements—(1) Initial divestiture requirements. Within...

  19. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program § 236...

  20. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program § 236...

  1. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program § 236...

  2. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program § 236...

  3. 8 CFR 236.13 - Ineligible aliens.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program § 236...

  4. 48 CFR 2409.470 - HUD regulations on debarment, suspension, and ineligibility.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false HUD regulations on debarment, suspension, and ineligibility. 2409.470 Section 2409.470 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS...

  5. 48 CFR 2409.470 - HUD regulations on debarment, suspension, and ineligibility.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false HUD regulations on debarment, suspension, and ineligibility. 2409.470 Section 2409.470 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS...

  6. 48 CFR 1509.406-3 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension and Ineligibility 1509.406-3 Procedures. (a... who do not appear on the GSA Consolidated List; e.g., those who are ineligible based on a settlement...) Obtain the HCA's recommendation prior to reaching a voluntary exclusion settlement with a Contractor in...

  7. 7 CFR 4290.720 - Enterprises that may be ineligible for Financing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... wells, wind farms, or power facilities (including solar, geothermal, hydroelectric, or biomass power... the majority of the activities of the Enterprise. Examples include motion pictures. (e) Farm land... ineligible for Farm Credit System Assistance. If one or more Farm Credit System Institutions or their...

  8. 41 CFR 60-250.68 - Reinstatement of ineligible contractors.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Reinstatement of ineligible contractors. 60-250.68 Section 60-250.68 Public Contracts and Property Management Other Provisions... OTHER PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.68 Reinstatement of...

  9. 41 CFR 60-250.68 - Reinstatement of ineligible contractors.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Reinstatement of ineligible contractors. 60-250.68 Section 60-250.68 Public Contracts and Property Management Other Provisions... OTHER PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.68 Reinstatement of...

  10. 41 CFR 60-250.68 - Reinstatement of ineligible contractors.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false Reinstatement of ineligible contractors. 60-250.68 Section 60-250.68 Public Contracts and Property Management Other Provisions... OTHER PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.68 Reinstatement of...

  11. 42 CFR 68.5 - Who is ineligible to participate?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.5 Who is ineligible to... Programs, (7) NIH Undergraduate Scholarship Program (UGSP), (8) Physicians Shortage Area Scholarship... examples of programs that have a service obligation: (1) Armed Forces (Army, Navy, or Air Force...

  12. 42 CFR 68.5 - Who is ineligible to participate?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.5 Who is ineligible to... Programs, (7) NIH Undergraduate Scholarship Program (UGSP), (8) Physicians Shortage Area Scholarship... examples of programs that have a service obligation: (1) Armed Forces (Army, Navy, or Air Force...

  13. 13 CFR 120.884 - Ineligible costs for 504 loans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Construction equipment (except for heavy duty construction equipment integral to a business' operations and... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Ineligible costs for 504 loans. 120.884 Section 120.884 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS...

  14. Endoscopic spray cryotherapy for esophageal cancer: safety and efficacy

    PubMed Central

    Greenwald, Bruce D.; Dumot, John A.; Abrams, Julian A.; Lightdale, Charles J.; David, Donald S.; Nishioka, Norman S.; Yachimski, Patrick; Johnston, Mark H.; Shaheen, Nicholas J.; Zfass, Alvin M.; Smith, Jenny O.; Gill, Kanwar Rupinder S.; Burdick, J. Steven; Mallat, Damien; Wolfsen, Herbert C.

    2011-01-01

    Background Few options exist for patients with localized esophageal cancer ineligible for conventional therapies. Endoscopic spray cryotherapy with low-pressure liquid nitrogen has demonstrated efficacy in this setting in early studies. Objective To assess the safety and efficacy of cryotherapy in esophageal carcinoma. Design Multicenter, retrospective cohort study. Setting Ten academic and community medical centers between 2006 and 2009. Patients Subjects with esophageal carcinoma in whom conventional therapy failed and those who refused or were ineligible for conventional therapy. Interventions Cryotherapy with follow-up biopsies. Treatment was complete when tumor eradication was confirmed by biopsy or when treatment was halted because of tumor progression, patient preference, or comorbid condition. Main Outcome Measurements Complete eradication of luminal cancer and adverse events. Results Seventy-nine subjects (median age 76 years, 81% male, 94% with adenocarcinoma) were treated. Tumor stage included T1-60, T2-16, and T3/4-3. Mean tumor length was 4.0 cm (range 1–15 cm). Previous treatment including endoscopic resection, photodynamic therapy, esophagectomy, chemotherapy, and radiation therapy failed in 53 subjects (67%). Forty-nine completed treatment. Complete response of intraluminal disease was seen in 31 of 49 subjects (61.2%), including 18 of 24 (75%) with mucosal cancer. Mean (standard deviation) length of follow-up after treatment was 10.6 (8.4) months overall and 11.5 (2.8) months for T1 disease. No serious adverse events were reported. Benign stricture developed in 10 (13%), with esophageal narrowing from previous endoscopic resection, radiotherapy, or photodynamic therapy noted in 9 of 10 subjects. Limitations Retrospective study design, short follow-up. Conclusions Spray cryotherapy is safe and well tolerated for esophageal cancer. Short-term results suggest that it is effective in those who could not receive conventional treatment, especially for those with mucosal cancer. PMID:20363410

  15. 10 CFR 40.38 - Ineligibility of certain applicants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Ineligibility of certain applicants. 40.38 Section 40.38 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF SOURCE MATERIAL License Applications § 40.38... security of the United States; or (2) The maintenance of a reliable and economical domestic source of...

  16. 34 CFR 364.51 - What requirements apply to determinations of eligibility or ineligibility?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true What requirements apply to determinations of eligibility or ineligibility? 364.51 Section 364.51 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION STATE...

  17. 34 CFR 364.51 - What requirements apply to determinations of eligibility or ineligibility?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What requirements apply to determinations of eligibility or ineligibility? 364.51 Section 364.51 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION STATE...

  18. 7 CFR 4290.720 - Enterprises that may be ineligible for Financing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... wells, wind farms, or power facilities (including solar, geothermal, hydroelectric, or biomass power... ineligible for Farm Credit System Assistance. If one or more Farm Credit System Institutions or their... that is not otherwise eligible to receive Financing from the Farm Credit System under the Farm Credit...

  19. 7 CFR 4290.720 - Enterprises that may be ineligible for Financing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... wells, wind farms, or power facilities (including solar, geothermal, hydroelectric, or biomass power... ineligible for Farm Credit System Assistance. If one or more Farm Credit System Institutions or their... that is not otherwise eligible to receive Financing from the Farm Credit System under the Farm Credit...

  20. 7 CFR 4279.114 - Ineligible purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... § 4279.114 Ineligible purposes. (a) Distribution or payment to an individual owner, partner, stockholder... retain any portion of the ownership of the borrower. (b) Projects in excess of $1 million that would... than 50 employees. (c) Projects in excess of $1 million that would increase direct employment by more...

  1. 9 CFR 351.19 - Refusal of certification for specific lots.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND VOLUNTARY INSPECTION AND CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Remedies... lot of technical animal fat is ineligible for certification under § 351.3, or any materials to be used in a lot of technical animal fat would make the technical animal fat ineligible for such...

  2. 9 CFR 351.19 - Refusal of certification for specific lots.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND VOLUNTARY INSPECTION AND CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Remedies... lot of technical animal fat is ineligible for certification under § 351.3, or any materials to be used in a lot of technical animal fat would make the technical animal fat ineligible for such...

  3. 9 CFR 351.19 - Refusal of certification for specific lots.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND VOLUNTARY INSPECTION AND CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Remedies... lot of technical animal fat is ineligible for certification under § 351.3, or any materials to be used in a lot of technical animal fat would make the technical animal fat ineligible for such...

  4. 9 CFR 351.19 - Refusal of certification for specific lots.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND VOLUNTARY INSPECTION AND CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Remedies... lot of technical animal fat is ineligible for certification under § 351.3, or any materials to be used in a lot of technical animal fat would make the technical animal fat ineligible for such...

  5. 42 CFR 68c.5 - Who is ineligible to participate?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Who is ineligible to participate? 68c.5 Section 68c.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT CONTRACEPTION AND INFERTILITY...

  6. 42 CFR 68c.5 - Who is ineligible to participate?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Who is ineligible to participate? 68c.5 Section 68c.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT CONTRACEPTION AND INFERTILITY...

  7. 42 CFR 68c.5 - Who is ineligible to participate?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Who is ineligible to participate? 68c.5 Section 68c.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT CONTRACEPTION AND INFERTILITY...

  8. 24 CFR 570.456 - Ineligible activities and limitations on eligible activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Ineligible activities and limitations on eligible activities. 570.456 Section 570.456 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND...

  9. 44 CFR 80.9 - Eligible and ineligible costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ACQUISITION AND RELOCATION FOR OPEN SPACE Requirements Prior to Award § 80.9 Eligible and ineligible costs. (a... eligible entity, compensation for the land is not an allowable cost, but compensation for development... costs for activities directly related to the development of the project proposal. These costs can only...

  10. Racial Disparities in Hepatitis C Treatment Eligibility.

    PubMed

    Sims, Omar; Pollio, David; Hong, Barry; North, Carol

    2017-01-01

    Hepatitis C (HCV) is more prevalent in African Americans than in any other racial group in the United States. However, African Americans are more likely to be deemed ineligible for HCV treatment than non-African Americans. There has been limited research into the origins of racial disparities in HCV treatment eligibility. The purpose of this study was to compare medical and non-medical characteristics commonly assessed in clinical practice that could potentially contribute to HCV treatment ineligibility disparities between African American and non-African American patients. Patients with confirmed HCV RNA considering treatment (n = 309) were recruited from university-affiliated and VA liver and infectious disease clinics. African Americans and non-African Americans did not differ in prevalence of lifetime and current psychiatric disorders and risky behaviors, and HCV knowledge. HCV clinical characteristics were similar between both groups in terms of HCV exposure history, number of months aware of HCV diagnosis, stage of fibrosis, and HCV virologic levels. African Americans did have higher proportions of diabetes, renal disease, and bleeding ulcer. No clinical evidence was found to indicate that African Americans should be more often deemed ineligible for HCV treatment than other racial groups. Diabetes and renal disease do not fully explain the HCV treatment ineligibility racial disparity, because HCV patients with these conditions are priority patients for HCV treatment because of their greater risk for cirrhosis, steatosis, and hepatocellular carcinoma. The findings suggest that an underlying contributor to the HCV treatment eligibility disparity disfavoring African Americans could be racial discrimination.

  11. Does conflict control occur without awareness? Evidence from an ERP study.

    PubMed

    Wang, Baoxi; Xiang, Ling; Li, Juan

    2013-01-15

    The relationship between conflict control and awareness has attracted extensive interest. Although researchers have investigated the relationship between response conflict and awareness, it still remains unclear whether stimulus conflict can occur outside of awareness. In addition, previous studies on the role of awareness in conflict control have ignored the fact that conflict control includes both conflict detection and resolution. A modified version of the flanker task was used to manipulate stimulus and response conflicts under both masked and unmasked conditions. The masked condition elicited a sequence of distinct event-related potential components that were also observed in the unmasked condition. N2 amplitudes presented the following pattern: incongruent-eligible>incongruent-ineligible>congruent, they did not show any difference under the masked and unmasked conditions, suggesting that detection of stimulus-related conflict revealed by the comparison between incongruent-ineligible and congruent trials, and response-related conflict revealed by the comparison between incongruent-eligible and incongruent-ineligible trials can occur in the absence of awareness, and unconscious conflict detection might involve the same neural network employed for conscious conflict detection. Late positive component (LPC) amplitudes also presented as incongruent-eligible>incongruent-ineligible>congruent at CPz and Pz, irrespective of conscious awareness. However, LPC amplitudes under the masked condition were markedly reduced compared to unmasked trials. These LPC findings suggest that stimulus- and response-related conflict resolution can occur in the absence of awareness; furthermore, unconscious conflict resolution might involve a weaker cognitive control network compared to conscious conflict resolution. These findings have important implications for the theories concerning the relationship between cognitive control and awareness. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. Thrombectomy in patients ineligible for iv tPA (THRILL).

    PubMed

    Bendszus, Martin; Thomalla, Götz; Knauth, Michael; Hacke, Werner; Bonekamp, Susanne; Fiehler, Jens

    2015-08-01

    A relevant proportion of patients with acute ischemic stroke are ineligible for intravenous thrombolysis with recombinant tissue plasminogen activator. Mechanical thrombectomy offers a treatment alternative for these patients; however, only few data are available on its safety and efficacy. The aim of this study was to compare safety and efficacy of stent retrievers as device class with best medical care alone in acute stroke patients with large intracranial vessel occlusion in the anterior circulation who are not eligible for intravenous thrombolysis with recombinant tissue plasminogen activator up to eight-hours of symptom onset. 'Thrombectomy in patients ineligible for iv tPA' is a prospective, open-label, blinded end-point, binational (Germany and Austria), two-arm, randomized, controlled, post-market study. Primary end-point is the modified Rankin Score shift analysis 90 days (±14) after stroke. Secondary end-points are excellent neurological outcomes (modified Rankin Score ≤ 1), good neurological outcomes (modified Rankin Score ≤ 2 or National Institutes of Health Stroke Scale improvement ≥ 10), difference between predicted infarct volume and actual core infarct volume (computed tomography or magnetic resonance imaging) at 30 (±6) h post-ictus, successful recanalization (thrombolysis in cerebral infarction score 2b or 3), functional health status 90 (±14) days after stroke (European Quality of Life-5 Dimensions) as well as common safety end-points (adverse event, serious adverse event, symptomatic intracranial haemorrhage at 30 (±6) h, death, or dependency). Whether mechanical thrombectomy in patients with acute ischemic stroke who are not eligible for intravenous thrombolysis with recombinant tissue plasminogen activator improves clinical outcomes is unclear. 'Thrombectomy in patients ineligible for iv tPA' may change clinical practice by providing evidence of an effective and safe treatment for such patients. © 2015 World Stroke Organization.

  13. Forms of attrition in a longitudinal study of religion and health in older adults and implications for sample bias

    PubMed Central

    Hayward, R. David; Krause, Neal

    2014-01-01

    The use of longitudinal designs in the field of religion and health makes it important to understand how attrition bias may affect findings in this area. This study examines attrition in a 4-wave, 8-year study of older adults. Attrition resulted in a sample biased towards more educated and more religiously-involved individuals. Conditional linear growth curve models found that trajectories of change for some variables differed among attrition categories. Ineligibles had worsening depression, declining control, and declining attendance. Mortality was associated with worsening religious coping styles. Refusers experienced worsening depression. Nevertheless, there was no evidence of bias in the key religion and health results. PMID:25257794

  14. Forms of Attrition in a Longitudinal Study of Religion and Health in Older Adults and Implications for Sample Bias.

    PubMed

    Hayward, R David; Krause, Neal

    2016-02-01

    The use of longitudinal designs in the field of religion and health makes it important to understand how attrition bias may affect findings in this area. This study examines attrition in a 4-wave, 8-year study of older adults. Attrition resulted in a sample biased toward more educated and more religiously involved individuals. Conditional linear growth curve models found that trajectories of change for some variables differed among attrition categories. Ineligibles had worsening depression, declining control, and declining attendance. Mortality was associated with worsening religious coping styles. Refusers experienced worsening depression. Nevertheless, there was no evidence of bias in the key religion and health results.

  15. 40 CFR 35.918-2 - Eligible and ineligible costs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Eligible and ineligible costs. 35.918-2 Section 35.918-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.918-2...

  16. 40 CFR 35.918-2 - Eligible and ineligible costs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Eligible and ineligible costs. 35.918-2 Section 35.918-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.918-2...

  17. 40 CFR 35.918-2 - Eligible and ineligible costs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Eligible and ineligible costs. 35.918-2 Section 35.918-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.918-2...

  18. 40 CFR 35.918-2 - Eligible and ineligible costs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Eligible and ineligible costs. 35.918-2 Section 35.918-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.918-2...

  19. 20 CFR 416.435 - Change in status involving a couple; ineligibility occurs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Change in status involving a couple; ineligibility occurs. 416.435 Section 416.435 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Amount of Benefits § 416.435 Change in status involving a...

  20. 20 CFR 416.426 - Change in status involving an individual; ineligibility occurs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Change in status involving an individual; ineligibility occurs. 416.426 Section 416.426 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Amount of Benefits § 416.426 Change in status involving...

  1. 20 CFR 416.426 - Change in status involving an individual; ineligibility occurs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Change in status involving an individual; ineligibility occurs. 416.426 Section 416.426 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Amount of Benefits § 416.426 Change in status involving...

  2. 20 CFR 416.426 - Change in status involving an individual; ineligibility occurs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Change in status involving an individual; ineligibility occurs. 416.426 Section 416.426 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Amount of Benefits § 416.426 Change in status involving...

  3. 20 CFR 416.435 - Change in status involving a couple; ineligibility occurs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Change in status involving a couple; ineligibility occurs. 416.435 Section 416.435 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Amount of Benefits § 416.435 Change in status involving a...

  4. 40 CFR 35.918-2 - Eligible and ineligible costs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Eligible and ineligible costs. 35.918-2 Section 35.918-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.918-2...

  5. 8 CFR 245a.18 - Ineligibility and applicability of grounds of inadmissibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Ineligibility and applicability of grounds of inadmissibility. 245a.18 Section 245a.18 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... STATUS UNDER SECTION 245A OF THE IMMIGRATION AND NATIONALITY ACT Legal Immigration Family Equity (LIFE...

  6. 8 CFR 245a.18 - Ineligibility and applicability of grounds of inadmissibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Ineligibility and applicability of grounds of inadmissibility. 245a.18 Section 245a.18 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... STATUS UNDER SECTION 245A OF THE IMMIGRATION AND NATIONALITY ACT Legal Immigration Family Equity (LIFE...

  7. 8 CFR 245a.18 - Ineligibility and applicability of grounds of inadmissibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Ineligibility and applicability of grounds of inadmissibility. 245a.18 Section 245a.18 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... STATUS UNDER SECTION 245A OF THE IMMIGRATION AND NATIONALITY ACT Legal Immigration Family Equity (LIFE...

  8. 45 CFR 1336.35 - Appeal of ineligibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposes are ineligible for funding by the Commissioner of ANA, may appeal the Commissioner's ruling to the... notification. (b) The appeal must clearly identify the issue(s) in dispute and contain a statement of the applicant's position on such issue(s) along with pertinent facts and reasons in support of the position. (c...

  9. 36 CFR 1011.17 - Will a debtor who owes a debt be ineligible for Presidio Trust licenses, permits, leases...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., permits, leases, privileges or services? Unless prohibited by law, the Presidio Trust may terminate... be ineligible for Presidio Trust licenses, permits, leases, privileges or services? 1011.17 Section 1011.17 Parks, Forests, and Public Property PRESIDIO TRUST DEBT COLLECTION Procedures To Collect...

  10. 76 FR 77831 - 2012 Presidential Candidate Matching Fund Submission Dates and Post Date of Ineligibility Dates...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... statement'') after their dates of ineligibility (``DOI''). Candidates are required to submit a NOCO... notified of their DOI by the Commission. A Candidate who has net outstanding campaign obligations post-DOI... each matching fund request submitted after the candidate's DOI. These statements are due just before...

  11. 30 CFR 204.212 - What if I took relief for which I was ineligible?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What if I took relief for which I was ineligible? 204.212 Section 204.212 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing Relief § 204.212...

  12. 24 CFR 1003.207 - Ineligible activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... under the provisions of §§ 1003.201 through 1003.206 is ineligible to be assisted with ICDBG funds. This... following activities may not be assisted with ICDBG funds: (1) Buildings or portions thereof used for the general conduct of government as defined at § 1003.4 cannot be assisted with ICDBG funds. This does not...

  13. 24 CFR 1003.207 - Ineligible activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... under the provisions of §§ 1003.201 through 1003.206 is ineligible to be assisted with ICDBG funds. This... following activities may not be assisted with ICDBG funds: (1) Buildings or portions thereof used for the general conduct of government as defined at § 1003.4 cannot be assisted with ICDBG funds. This does not...

  14. 24 CFR 1003.207 - Ineligible activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... under the provisions of §§ 1003.201 through 1003.206 is ineligible to be assisted with ICDBG funds. This... following activities may not be assisted with ICDBG funds: (1) Buildings or portions thereof used for the general conduct of government as defined at § 1003.4 cannot be assisted with ICDBG funds. This does not...

  15. 75 FR 7552 - Exclusion of Certain Military Pay From Deemed Income and Resources

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... pursuant to 37 U.S.C. 310; and Family separation allowance the ineligible spouse or parent received from... separation allowance an ineligible parent (or stepparent) received from one of the uniformed services... a reduction in, or loss of, benefits because their spouse or parent serves in a combat zone. DATES...

  16. The New Faculty Majority: Somewhat Satisfied but Not Eligible for Tenure.

    ERIC Educational Resources Information Center

    Gappa, Judith M.

    2000-01-01

    Discusses the employment conditions and levels of satisfaction of the increasing numbers of full- and part-time college faculty members ineligible for tenure. Recommends extension of academic freedom, a reasonable amount of job security for all faculty, inclusion of tenure-ineligible faculty members in governance, and basing faculty rewards and…

  17. 32 CFR 553.17 - Persons ineligible for burial in an Army national cemetery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Persons ineligible for burial in an Army national cemetery. 553.17 Section 553.17 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES ARMY NATIONAL CEMETERIES § 553.17 Persons...

  18. 20 CFR 418.3115 - What events will make you ineligible for a subsidy?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false What events will make you ineligible for a subsidy? 418.3115 Section 418.3115 Employees' Benefits SOCIAL SECURITY ADMINISTRATION MEDICARE SUBSIDIES Medicare Part D Subsidies Eligibility for A Medicare Prescription Drug Subsidy § 418.3115 What events will...

  19. 20 CFR 418.3115 - What events will make you ineligible for a subsidy?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What events will make you ineligible for a subsidy? 418.3115 Section 418.3115 Employees' Benefits SOCIAL SECURITY ADMINISTRATION MEDICARE SUBSIDIES Medicare Part D Subsidies Eligibility for A Medicare Prescription Drug Subsidy § 418.3115 What events will...

  20. 20 CFR 418.3115 - What events will make you ineligible for a subsidy?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false What events will make you ineligible for a subsidy? 418.3115 Section 418.3115 Employees' Benefits SOCIAL SECURITY ADMINISTRATION MEDICARE SUBSIDIES Medicare Part D Subsidies Eligibility for A Medicare Prescription Drug Subsidy § 418.3115 What events will...

  1. 20 CFR 416.426 - Change in status involving an individual; ineligibility occurs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Change in status involving an individual; ineligibility occurs. 416.426 Section 416.426 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Amount of Benefits § 416.426 Change in status involving...

  2. 20 CFR 416.435 - Change in status involving a couple; ineligibility occurs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Change in status involving a couple; ineligibility occurs. 416.435 Section 416.435 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Amount of Benefits § 416.435 Change in status involving a...

  3. 20 CFR 416.435 - Change in status involving a couple; ineligibility occurs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Change in status involving a couple; ineligibility occurs. 416.435 Section 416.435 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Amount of Benefits § 416.435 Change in status involving a...

  4. 20 CFR 416.426 - Change in status involving an individual; ineligibility occurs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Change in status involving an individual; ineligibility occurs. 416.426 Section 416.426 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Amount of Benefits § 416.426 Change in status involving...

  5. Generalizability of clinical trials of advanced melanoma in the real-world, population-based setting.

    PubMed

    Sam, Davis; Gresham, Gillian; Abdel-Rahman, Omar; Cheung, Winson Y

    2018-06-18

    Results from novel therapeutics trials are not always generalizable to real-world patients. We aimed to determine the pattern in which trial findings are applied in a population-based setting of melanoma patients and consequent treatment outcomes. Patients with unresectable disease during 2011-2014 and referred to cancer centers in a large Canadian province were retrospectively reviewed. Based on eligibility criteria as described in registration trials of vemurafenib (Vem) and ipilimumab (Ipi), we classified patients into trial-eligible and ineligible and those treated and untreated with these agents. We identified 290 patients with known BRAF status for the Vem analysis and 212 patients previously treated with first-line agents for the Ipi analysis. For the Vem cohort, a total of 49 patients were considered trial-eligible, of whom 36 (73%) received treatment. For the Ipi cohort, there were 119 trial-eligible cases of whom 43 (36%) received therapy. Factors other than eligibility criteria most frequently associated with non-treatment in these cohorts included concerns regarding treatment harm and patient preferences. In multivariable analysis, overall survival was improved in Vem cohort patients considered trial-eligible and treated compared to those who were ineligible. Within the Ipi cohort, survival was improved in trial-eligible patients regardless of whether they received Ipi compared to ineligible patients. Real-world uptake of new melanoma treatments was suboptimal, and non-use in trial-eligible patients was frequent. Future clinical trials that are more pragmatically designed to include participants who better reflect the real-world population may facilitate increased uptake of novel therapeutics into routine clinical practice.

  6. 13 CFR 108.720 - Small Businesses that may be ineligible for financing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ineligible for financing. (a) Relenders or reinvestors. You are not permitted to finance any business that is... are not permitted to finance a passive business. (1) Definition. A business is passive if: (i) It is... the prior written approval of SBA, you may finance a passive business if it is a Small Business and it...

  7. 13 CFR 108.720 - Small Businesses that may be ineligible for financing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ineligible for financing. (a) Relenders or reinvestors. You are not permitted to finance any business that is... are not permitted to finance a passive business. (1) Definition. A business is passive if: (i) It is... the prior written approval of SBA, you may finance a passive business if it is a Small Business and it...

  8. 13 CFR 108.720 - Small Businesses that may be ineligible for financing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ineligible for financing. (a) Relenders or reinvestors. You are not permitted to finance any business that is... are not permitted to finance a passive business. (1) Definition. A business is passive if: (i) It is... the prior written approval of SBA, you may finance a passive business if it is a Small Business and it...

  9. 28 CFR 74.15 - Notice of the right to appeal a finding of ineligibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Notice of the right to appeal a finding... LIBERTIES ACT REDRESS PROVISION Appeal Procedures § 74.15 Notice of the right to appeal a finding of... determination, the right to petition for a reconsideration of the determination of ineligibility to the...

  10. 24 CFR 761.17 - Eligible and ineligible activities for funding.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... for funding. 761.17 Section 761.17 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND... Funding § 761.17 Eligible and ineligible activities for funding. (a) Eligible activities. One or more of the eligible activities described in 42 U.S.C. 11903 and in this § 761.17(a) are eligible for funding...

  11. 24 CFR 761.17 - Eligible and ineligible activities for funding.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... for funding. 761.17 Section 761.17 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND... Funding § 761.17 Eligible and ineligible activities for funding. (a) Eligible activities. One or more of the eligible activities described in 42 U.S.C. 11903 and in this § 761.17(a) are eligible for funding...

  12. 22 CFR Appendix B to Part 513 - Certification Regarding Debarment, Suspension, Ineligibility and Voluntary Exclusion-Lower Tier...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Certification Regarding Debarment, Suspension, Ineligibility and Voluntary Exclusion-Lower Tier Covered Transactions B Appendix B to Part 513 Foreign Relations... REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Pt. 513, App. B Appendix B to Part 513—Certification Regarding...

  13. 22 CFR 120.1 - General authorities, receipt of licenses, and ineligibility.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... ineligibility. 120.1 Section 120.1 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS...) Section 38 of the Arms Export Control Act (22 U.S.C. 2778), as amended, authorizes the President to... well as other relevant authorities in the Arms Export Control Act (22 U.S.C. 2751 et seq.). By virtue...

  14. 20 CFR 416.1161 - Income of an ineligible spouse, ineligible parent, and essential person for deeming purposes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... parent, and essential person for deeming purposes. 416.1161 Section 416.1161 Employees' Benefits SOCIAL... laws other than the Social Security Act (See the appendix to this subpart.) (2) Any public income... title XX of the Social Security Act) to provide you with chore, attendant or homemaker services; (17...

  15. Felonious or violent criminal activity that prohibits gun ownership among prior purchasers of handguns: incidence and risk factors.

    PubMed

    Wright, Mona A; Wintemute, Garen J

    2010-10-01

    Federal law prohibits firearm possession by felons and certain others. Little is known about criminal activity resulting in new ineligibility to possess firearms among persons who have previously purchased them. Cohort study of handgun purchasers ages 21 to 49 in California in 1991, 2,761 with a non-prohibiting criminal history at the time of purchase and 4,495 with no prior criminal record, followed for up to 5 years. The primary outcome measures were the incidence and relative risk of conviction for a felony or violent misdemeanor resulting in ineligibility to possess firearms under (a) California law or (b) federal law. Secondary measures were the incidence and relative risk of conviction for murder, forcible rape, robbery, or aggravated assault; and of arrest for any crime. A new conviction for a felony or violent misdemeanor leading to ineligibility to possess firearms under federal law was identified for 0.9% of subjects with no prior criminal history and 4.5% of those with 1 or more prior convictions (hazard ratio, 5.1; 95% confidence interval, 3.3-7.7). Risk was related inversely to age and directly to the extent of the prior criminal history; incidence rates varied by a factor of 200 or more among subgroups based on these characteristics. Among legal purchasers of handguns, the incidence of new felonious and violent criminal activity resulting in ineligibility to possess firearms is low for those with no prior criminal history but is substantially higher for those with a prior criminal record and is affected by demographic characteristics.

  16. External validity of the ARISTOTLE trial in real-life atrial fibrillation patients.

    PubMed

    Hägg, Lovisa; Johansson, Cecilia; Jansson, Jan-Håkan; Johansson, Lars

    2014-10-01

    Our primary objective was to determine the proportion of patients with atrial fibrillation (AF) eligible for enrollment in a randomized controlled trial for a novel oral anticoagulant, the ARISTOTLE trial. A secondary objective was to describe the reasons for trial ineligibility. We performed a cross-sectional study of an unselected population including 2274 patients in Skellefteå, Sweden with at least one verified episode of AF on or before December 31, 2010. Patients were classified as suitable or unsuitable for anticoagulant treatment according to current guidelines. The enrollment criteria from the ARISTOTLE trial were extracted from the original publication and applied to the population. Among all patients with AF, 1579 were classified as suitable for anticoagulant treatment. Of these, only 658 patients (42%) were eligible for participation in the ARISTOTLE trial. Among the 921 patients ineligible for participation, 498 did not meet the ECG criteria, 272 had psychosocial problems, and in addition, 78 patients were excluded due to both of these criteria. Our study shows that a majority of the patients in an unselected population with AF suitable for anticoagulant treatment were ineligible for participation in the ARISTOTLE trial. The applicability of the ARISTOTLE trial is therefore unknown for a considerable proportion of patients with AF in real life. © 2014 John Wiley & Sons Ltd.

  17. 20 CFR 416.1166 - How we deem income to you and your eligible child from your ineligible spouse.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the household as described in § 416.1163(b). (c) Allocations for aliens who are sponsored by and have income deemed from your ineligible spouse. We also deduct an allocation for eligible aliens who have been.... Example 1. Mary, a blind individual, lives with her husband, John, and their disabled child, Peter. Mary...

  18. 20 CFR 416.1166 - How we deem income to you and your eligible child from your ineligible spouse.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the household as described in § 416.1163(b). (c) Allocations for aliens who are sponsored by and have income deemed from your ineligible spouse. We also deduct an allocation for eligible aliens who have been.... Example 1. Mary, a blind individual, lives with her husband, John, and their disabled child, Peter. Mary...

  19. 20 CFR 416.1166 - How we deem income to you and your eligible child from your ineligible spouse.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the household as described in § 416.1163(b). (c) Allocations for aliens who are sponsored by and have income deemed from your ineligible spouse. We also deduct an allocation for eligible aliens who have been.... Example 1. Mary, a blind individual, lives with her husband, John, and their disabled child, Peter. Mary...

  20. 20 CFR 416.1166 - How we deem income to you and your eligible child from your ineligible spouse.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the household as described in § 416.1163(b). (c) Allocations for aliens who are sponsored by and have income deemed from your ineligible spouse. We also deduct an allocation for eligible aliens who have been.... Example 1. Mary, a blind individual, lives with her husband, John, and their disabled child, Peter. Mary...

  1. 20 CFR 1002.135 - What types of discharge or separation from uniformed service will make the employee ineligible...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... uniformed service will make the employee ineligible for reemployment under USERRA? 1002.135 Section 1002.135... Eligibility For Reemployment Character of Service § 1002.135 What types of discharge or separation from... regulations of the uniformed service; (c) A commissioned officer dismissed as permitted under 10 U.S.C. 1161(a...

  2. 20 CFR 670.470 - May a person who is determined to be ineligible or an individual who is denied enrollment appeal...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false May a person who is determined to be ineligible or an individual who is denied enrollment appeal that decision? 670.470 Section 670.470 Employees... WORKFORCE INVESTMENT ACT Recruitment, Eligibility, Screening, Selection and Assignment, and Enrollment § 670...

  3. 20 CFR 416.1165 - How we deem income to you from your ineligible parent(s).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... disabled child, lives with his mother and father and a 12-year-old ineligible brother. His mother receives... who live with their mother. The children have no income but their mother receives $542 a month in... subtract the amount we allocate for the mother's needs, $422 (the Federal benefit rate for an individual...

  4. 20 CFR 416.1165 - How we deem income to you from your ineligible parent(s).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... disabled child, lives with his mother and father and a 12-year-old ineligible brother. His mother receives... who live with their mother. The children have no income but their mother receives $542 a month in... subtract the amount we allocate for the mother's needs, $422 (the Federal benefit rate for an individual...

  5. 9 CFR 94.7 - Disposal of animals, meats, and other articles ineligible for importation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Disposal of animals, meats, and other... RESTRICTED IMPORTATIONS § 94.7 Disposal of animals, meats, and other articles ineligible for importation. (a) Ruminants and swine, and fresh (chilled or frozen) meats, prohibited importation under §§ 94.1, 94.8, 94.9...

  6. 20 CFR 416.1165 - How we deem income to you from your ineligible parent(s).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false How we deem income to you from your... income to you from your ineligible parent(s). If you are a child living with your parents, we apply the...) through (e) of this section to determine your eligibility. To determine your benefit amount, we follow the...

  7. Hospitals ineligible for federal meaningful-use incentives have dismally low rates of adoption of electronic health records.

    PubMed

    Wolf, Larry; Harvell, Jennie; Jha, Ashish K

    2012-03-01

    The US government has dedicated substantial resources to help certain providers, such as short-term acute care hospitals and physicians, adopt and meaningfully use electronic health record (EHR) systems. We used national data to determine adoption rates of EHR systems among all types of inpatient providers that were ineligible for these same federal meaningful-use incentives: long-term acute care hospitals, rehabilitation hospitals, and psychiatric hospitals. Adoption rates for these institutions were dismally low: less than half of the rate among short-term acute care hospitals. Specifically, 12 percent of short-term acute care hospitals have at least a basic EHR system, compared with 6 percent of long-term acute care hospitals, 4 percent of rehabilitation hospitals, and 2 percent of psychiatric hospitals. To advance the creation of a nationwide health information technology infrastructure, federal and state policy makers should consider additional measures, such as adopting health information technology standards and EHR system certification criteria appropriate for these ineligible hospitals; including such hospitals in state health information exchange programs; and establishing low-interest loan programs for the acquisition and use of certified EHR systems by ineligible providers.

  8. Characteristics of the population eligible for and receiving publicly funded bariatric surgery in Canada

    PubMed Central

    2012-01-01

    Background Bariatric surgery is the most effective current treatment for severe obesity. Capacity to perform surgery within Canada’s public health system is limited and potential candidates face protracted wait times. A better understanding of the gaps between demand for surgery and the capacity to provide it is required. The purpose of this study was to quantify and characterize the bariatric surgery-eligible population in Canada in comparison to surgery-ineligible subjects and surgical recipients. Methods Data from adult (age > 20) respondents of the 2007–09 nationally representative Canadian Health Measures Survey (CHMS) were analyzed to estimate the prevalence and characteristics of the surgery-eligible and ineligible populations. Federally mandated administrative healthcare data (2007–08) were used to characterize surgical recipients. Results In 2007–09, an estimated 1.5 million obese Canadian adults met eligibility criteria for bariatric surgery. 19.2 million were surgery-ineligible (3.4 million obese and 15.8 million non-obese). Surgery-eligible Canadians had a mean BMI of 40.1 kg/m2 (95% CI 39.3 to 40.9 kg/m2) and, compared to the surgery-ineligible obese population, were more likely to be female (62 vs. 44%), 40–59 years old (55 vs. 48%), less educated (43 vs. 35%), in the lowest socioeconomic tertile (41 vs. 34%), and inactive (73 vs. 59%). Self-rated mental health and quality of life were lower and comorbidity was higher in surgery-eligible respondents compared with the ineligible populations. The annual proportion of Canadians eligible for surgery that actually underwent a publicly funded bariatric surgery between 2007–09 was 0.1%. Surgical recipients (n = 847) had a mean age of 43.6 years (SD 11.1) and 82% were female. With the exception of type 2 diabetes, obesity-related comorbidity prevalence was much lower in surgical recipients compared to those eligible for surgery. Conclusions The proportion of bariatric surgery-eligible Canadians that undergo publicly funded bariatric surgery is very low. There are notable differences in sociodemographic profiles and prevalence of comorbidities between surgery-eligible subjects and surgical recipients. PMID:22984790

  9. 34 CFR 222.179 - Under what circumstances may an ineligible LEA apply on behalf of a school for an emergency grant...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Under what circumstances may an ineligible LEA apply on behalf of a school for an emergency grant under the second priority? 222.179 Section 222.179 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION...

  10. 34 CFR 222.182 - Under what circumstances may an ineligible LEA apply on behalf of a school for a modernization...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Under what circumstances may an ineligible LEA apply on behalf of a school for a modernization grant under the fourth priority? 222.182 Section 222.182 Education... average per-student assessed value of real property available to be taxed for school purposes that is...

  11. 34 CFR 222.179 - Under what circumstances may an ineligible LEA apply on behalf of a school for an emergency grant...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Under what circumstances may an ineligible LEA apply on behalf of a school for an emergency grant under the second priority? 222.179 Section 222.179 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION...

  12. 34 CFR 222.182 - Under what circumstances may an ineligible LEA apply on behalf of a school for a modernization...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Under what circumstances may an ineligible LEA apply on behalf of a school for a modernization grant under the fourth priority? 222.182 Section 222.182 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION...

  13. 20 CFR 416.1165 - How we deem income to you from your ineligible parent(s).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... described in § 416.1163(b). (c) Allocations for aliens who are sponsored by and have income deemed from your ineligible parent. We also deduct an allocation for eligible aliens who have been sponsored by and have... only one parent lives with you. (e)(1) When you are the only eligible child. If you are the only...

  14. 20 CFR 416.1165 - How we deem income to you from your ineligible parent(s).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... described in § 416.1163(b). (c) Allocations for aliens who are sponsored by and have income deemed from your ineligible parent. We also deduct an allocation for eligible aliens who have been sponsored by and have... only one parent lives with you. (e)(1) When you are the only eligible child. If you are the only...

  15. Pharmacological treatment and perceived health status during 1-year follow up in patients diagnosed with coronary artery disease, but ineligible for revascularization. Results from the Euro Heart Survey on Coronary Revascularization.

    PubMed

    Lenzen, Mattie; Scholte op Reimer, Wilma; Norekvål, Tone M; De Geest, Sabina; Fridlund, Bengt; Heikkilä, Johanna; Jaarsma, Tiny; Mårtensson, Jan; Moons, Philip; Smith, Karen; Stewart, Simon; Strömberg, Anna; Thompson, David R; Wijns, William

    2006-06-01

    It has been recognized that a clinically significant portion of patients with coronary artery disease (CAD) continue to experience anginal and other related symptoms that are refractory to the combination of medical therapy and revascularization. The Euro Heart Survey on Revascularization (EHSCR) provided an opportunity to assess pharmacological treatment and outcome in patients with proven CAD who were ineligible for revascularization. We performed a secondary analysis of EHS-CR data. After excluding patients with ST-elevation myocardial infarction and those in whom revascularization was not indicated, 4409 patients remained in the analyses. We selected two groups: (1) patients in whom revascularization was the preferred treatment option (n = 3777, 86%), and (2) patients who were considered ineligible for revascularization (n = 632, 14%). Patient ineligible for revascularization had a worse risk profile, more often had a total occlusion (59% vs. 37%, p < 0.001), were treated more often with ACE-inhibitors (65% vs. 55%, p < 0.001) but less likely with aspirin (83% vs. 88%, p < 0.001). Overall, they had higher case-fatality at 1-year (7.0% vs. 3.7%, p < 0.001). Regarding self-perceived health status, measured via the EuroQol 5D (EQ-5D) questionnaire, these same patients reported more problems on all dimensions of the EQ-5D. Furthermore, in the revascularization group we observed an increase between discharge and 1-year follow up (utility score from 0.85 to 1.00) whereas patients ineligible for revascularization did not improve over time (utility score remained 0.80) In this large cohort of European patients with CAD, those considered ineligible for revascularization had more co-morbidities and risk factors, and scored worse on self-perceived health status as compared to revascularized patients in the revascularization group. With the exception of ACE-inhibitors and aspirin, there were no major differences regarding drug treatment between the two groups. Given these clinically significant observations, there appears to be a role for nurse-led, multidisciplinary, rehabilitation teams that target clinically vulnerable patients whose symptoms remain refractory to standard medical care.

  16. The JAGUAR Score Predicts 1-Month Disability/Death in Ischemic Stroke Patient Ineligible for Recanalization Therapy.

    PubMed

    Widhi Nugroho, Aryandhito; Arima, Hisatomi; Takashima, Naoyuki; Fujii, Takako; Shitara, Satoshi; Miyamatsu, Naomi; Sugimoto, Yoshihisa; Nagata, Satoru; Komori, Masaru; Kita, Yoshikuni; Miura, Katsuyuki; Nozaki, Kazuhiko

    2018-06-22

    Most available scoring system to predict outcome after acute ischemic stroke (AIS) were established in Western countries. We aimed to develop a simple prediction score of 1-month severe disability/death after onset in AIS patients ineligible for recanalization therapy based on readily and widely obtainable on-admission clinical, laboratory and radiological examinations in Asian developing countries. Using the Shiga Stroke Registry, a large population-based registry in Japan, multivariable logistic regression analysis was conducted in 1617 AIS patients ineligible for recanalization therapy to yield ß-coefficients of significant predictors of 1-month modified Rankin Scale score of 5-6, which were then multiplied by a specific constant and rounded to nearest integer to develop 0-10 points system. Model discrimination and calibration were evaluated in the original and bootstrapped population. Japan Coma Scale score (J), age (A), random glucose (G), untimely onset-to-arrival time (U), atrial fibrillation (A), and preadmission dependency status according to the modified Rankin Scale score (R), were recognized as independent predictors of outcome. Each of their β-coefficients was multiplied by 1.3 creating the JAGUAR score. Its area under the curve (95% confidence interval) was .901 (.880- .922) and .901 (.900- .901) in the original and bootstrapped population, respectively. It was found to have good calibration in both study population (P = .27). The JAGUAR score can be an important prediction tool of severe disability/death in AIS patients ineligible for recanalization therapy that can be applied on admission with no complicated calculation and multimodal neuroimaging necessary, thus suitable for Asian developing countries. Copyright © 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  17. 78 FR 53005 - Agency Information Collection Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... simulation studies in the past. Businesses are ineligible for the sample and will not be contacted. Number of Responses: Each respondent will complete the process once. Total Annual Burden Hours: It is estimated that...

  18. 47 CFR 54.639 - Ineligible expenses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., including the following: i. Computers, including servers, and related hardware (e.g., printers, scanners, laptops), unless used exclusively for network management, maintenance, or other network operations; ii... installation/construction; marketing studies, marketing activities, or outreach to potential network members...

  19. 47 CFR 54.639 - Ineligible expenses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., including the following: i. Computers, including servers, and related hardware (e.g., printers, scanners, laptops), unless used exclusively for network management, maintenance, or other network operations; ii... installation/construction; marketing studies, marketing activities, or outreach to potential network members...

  20. The Recruitment Experience of a Randomized Clinical Trial to Aid Young Adult Smokers to Stop Smoking without Weight Gain with Interactive Technology.

    PubMed

    Coday, Mace; Richey, Phyllis; Thomas, Fridtjof; Tran, Quynh T; Terrell, Sarah B; Tylavsky, Fran; Miro, Danielle; Caufield, Margaret; Johnson, Karen C

    2016-04-15

    Multiple recruitment strategies are often needed to recruit an adequate number of participants, especially hard to reach groups. Technology-based recruitment methods hold promise as a more robust form of reaching and enrolling historically hard to reach young adults. The TARGIT study is a randomized two-arm clinical trial in young adults using interactive technology testing an efficacious proactive telephone Quitline versus the Quitline plus a behavioral weight management intervention focusing on smoking cessation and weight change. All randomized participants in the TARGIT study were required to be a young adult smoker (18-35 years), who reported smoking at least 10 cigarettes per day, had a BMI < 40 kg/m 2, and were willing to stop smoking and not gain weight. Traditional recruitment methods were compared to technology-based strategies using standard descriptive statistics based on counts and proportions to describe the recruitment process from initial pre-screening (PS) to randomization into TARGIT. Participants at PS were majority Black (59.80%), female (52.66%), normal or over weight (combined 62.42%), 29.5 years old, and smoked 18.4 cigarettes per day. There were differences in men and women with respect to reasons for ineligibility during PS (p < 0.001; ignoring gender specific pregnancy-related ineligibility). TARGIT experienced a disproportionate loss of minorities during recruitment as well as a prolonged recruitment period due to either study ineligibility or not completing screening activities. Recruitment into longer term behavioral change intervention trials can be challenging and multiple methods are often required to recruit hard to reach groups.

  1. 21 CFR 1271.65 - How do I store an HCT/P from a donor determined to be ineligible, and what uses of the HCT/P are...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false How do I store an HCT/P from a donor determined to be ineligible, and what uses of the HCT/P are not prohibited? 1271.65 Section 1271.65 Food and Drugs... TISSUE-BASED PRODUCTS Donor Eligibility § 1271.65 How do I store an HCT/P from a donor determined to be...

  2. 21 CFR 1271.65 - How do I store an HCT/P from a donor determined to be ineligible, and what uses of the HCT/P are...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false How do I store an HCT/P from a donor determined to be ineligible, and what uses of the HCT/P are not prohibited? 1271.65 Section 1271.65 Food and Drugs... TISSUE-BASED PRODUCTS Donor Eligibility § 1271.65 How do I store an HCT/P from a donor determined to be...

  3. Time to Initiation of Antiretroviral Therapy Among Patients Who Are ART Eligible in Rwanda: Improvement Over Time

    PubMed Central

    Teasdale, Chloe A.; Wang, Chunhui; Francois, Uwinkindi; d’Amour Ndahimana, Jean; Vincent, Mutabazi; Sahabo, Ruben; El-Sadr, Wafaa M.; Abrams, Elaine J.

    2016-01-01

    Background Delayed initiation of antiretroviral therapy (ART) in eligible patients is a concern in resource-limited countries. Methods We analyzed data on HIV-positive patients ≥15 years enrolled at 41 ICAP-supported health care facilities in Rwanda, 2005–2010, to determine time to ART initiation among patients eligible at enrollment compared with those ineligible or of indeterminate eligibility who become eligible during follow-up. ART eligibility was based on CD4+ cell count (CD4+) and WHO staging; patients lacking CD4+ and WHO stage were considered indeterminate. Cumulative incidence of reaching ART eligibility and to ART initiation after eligibility was generated using competing risk estimators. Results A total of 31,033 ART-naive adults were enrolled; 64.2% were female. At enrollment, 10,158 (32.7%) patients were ART eligible, 13,372 (43.1%) were ineligible for ART, and 7503 (24.2%) patients were indeterminate. Among patients retained in care pre-ART eligibility, 17.9% [95% confidence interval (CI): 17.2 to 18.6] of ineligible and 22.8% (95% CI: 21.7 to 23.8) of indeterminate patients at enrollment reached ART eligibility within 12 months. Cumulative incidence of ART initiation within 3 months for patients eligible at enrollment was 77.2% (95% CI: 76.4 to 78.0) compared with 67.9% (95% CI: 66.4 to 69.3) for ineligible and 63.8% (95% CI: 61.9 to 65.8) for patients with indeterminate eligibility at enrollment (P < 0.05). Over the study period, there was more rapid ART initiation for patients who became ART eligible. Conclusions We found higher rates of ART initiation within 3 months among patients who were ART eligible at enrollment compared with those who reached eligibility during follow-up. From 2006 to 2011, earlier initiation of ART after eligibility was observed likely reflecting improved program quality. PMID:25415291

  4. Impact of relative contraindications to home management in emergency department patients with low-risk pulmonary embolism.

    PubMed

    Vinson, David R; Drenten, Carrieann E; Huang, Jie; Morley, J Eileen; Anderson, Megan L; Reed, Mary E; Nishijima, Daniel K; Liu, Vincent

    2015-05-01

    Studies of adults presenting to the emergency department (ED) with acute pulmonary embolism (PE) suggest that those who are low risk on the PE Severity Index (classes I and II) can be managed safely without hospitalization. However, the impact of relative contraindications to home management on outcomes has not been described. To compare 5-day and 30-day adverse event rates among low-risk ED patients with acute PE without and with outpatient ineligibility criteria. We conducted a retrospective multicenter cohort study of adults presenting to the ED with acute low-risk PE between 2010 and 2012. We evaluated the association between outpatient treatment eligibility criteria based on a comprehensive list of relative contraindications and 5-day adverse events and 30-day outcomes, including major hemorrhage, recurrent venous thromboembolism, and all-cause mortality. Of 423 adults with acute low-risk PE, 271 (64.1%) had no relative contraindications to outpatient treatment (outpatient eligible), whereas 152 (35.9%) had at least one contraindication (outpatient ineligible). Relative contraindications were categorized as PE-related factors (n = 112; 26.5%), comorbid illness (n = 42; 9.9%), and psychosocial barriers (n = 19; 4.5%). There were no 5-day events in the outpatient-eligible group (95% upper confidence limit, 1.7%) and two events (1.3%; 95% confidence interval [CI], 0.1-5.0%) in the outpatient-ineligible group (P = 0.13). At 30 days, there were five events (two recurrent venous thromboemboli and three major bleeding events) in the outpatient-eligible group (1.8%; 95% CI, 0.7-4.4%) compared with nine in the ineligible group (5.9%; 95% CI, 2.7-10.9%; P < 0.05). This difference remained significant when controlling for PE severity class. Nearly two-thirds of adults presenting to the ED with low-risk PE were potentially eligible for outpatient therapy. Relative contraindications to outpatient management were associated with an increased frequency of adverse events at 30 days among adults with low-risk PE.

  5. Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices.

    PubMed

    Saver, Jeffrey L; Jovin, Tudor G; Smith, Wade S; Albers, Gregory W; Baron, Jean-Claude; Boltze, Johannes; Broderick, Joseph P; Davis, Lisa A; Demchuk, Andrew M; DeSena, Salvatore; Fiehler, Jens; Gorelick, Philip B; Hacke, Werner; Holt, Bill; Jahan, Reza; Jing, Hui; Khatri, Pooja; Kidwell, Chelsea S; Lees, Kennedy R; Lev, Michael H; Liebeskind, David S; Luby, Marie; Lyden, Patrick; Megerian, J Thomas; Mocco, J; Muir, Keith W; Rowley, Howard A; Ruedy, Richard M; Savitz, Sean I; Sipelis, Vitas J; Shimp, Samuel K; Wechsler, Lawrence R; Wintermark, Max; Wu, Ona; Yavagal, Dileep R; Yoo, Albert J

    2013-12-01

    The goal of the Stroke Treatment Academic Industry Roundtable (STAIR) meetings is to advance the development of stroke therapies. At STAIR VIII, consensus recommendations were developed for clinical trial strategies to demonstrate the benefit of endovascular reperfusion therapies for acute ischemic stroke. Prospects for success with forthcoming endovascular trials are robust, because new neurothrombectomy devices have superior reperfusion efficacy compared with earlier-generation interventions. Specific recommendations are provided for trial designs in 3 populations: (1) patients undergoing intravenous fibrinolysis, (2) early patients ineligible for or having failed intravenous fibrinolysis, and (3) wake-up and other late-presenting patients. Among intravenous fibrinolysis-eligible patients, key principles are that CT or MRI confirmation of target arterial occlusions should precede randomization; endovascular intervention should be pursued with the greatest rapidity possible; and combined intravenous and neurothrombectomy therapy is more promising than neurothrombectomy alone. Among patients ineligible for or having failed intravenous fibrinolysis, scientific equipoise was affirmed and the need to randomize all eligible patients emphasized. Vessel imaging to confirm occlusion is mandatory, and infarct core and penumbral imaging is desirable in later time windows. Additional STAIR VIII recommendations include approaches to test multiple devices in a single trial, utility weighting of disability end points, and adaptive designs to delineate time and tissue injury thresholds at which benefits from intervention no longer accrue. Endovascular research priorities in acute ischemic stroke are to perform trials testing new, highly effective neuro thrombectomy devices rapidly deployed in patients confirmed to have target vessel occlusions.

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hoppe, Bradford S., E-mail: bhoppe@floridaproton.org; Henderson, Randal; Pham, Dat

    Purpose: Proton therapy has been shown to reduce radiation dose to organs at risk (OAR) and could be used to safely escalate the radiation dose. We analyzed outcomes in a group of phase 2 study patients treated with dose-escalated proton therapy with concurrent chemotherapy for stage 3 non-small cell lung cancer (NSCLC). Methods and Materials: From 2009 through 2013, LU02, a phase 2 trial of proton therapy delivering 74 to 80 Gy at 2 Gy/fraction with concurrent chemotherapy for stage 3 NSCLC, was opened to accrual at our institution. Due to slow accrual and competing trials, the study was closed after justmore » 14 patients (stage IIIA, 9 patients; stage IIIB, 5 patients) were accrued over 4 years. During that same time period, 55 additional stage III patients were treated with high-dose proton therapy, including 7 in multi-institutional proton clinical trials, 4 not enrolled due to physician preference, and 44 who were ineligible based on strict entry criteria. An unknown number of patients were ineligible for enrollment due to insurance coverage issues and thus were treated with photon radiation. Median follow-up of surviving patients was 52 months. Results: Two-year overall survival and progression-free survival rates were 57% and 25%, respectively. Median lengths of overall survival and progression-free survival were 33 months and 14 months, respectively. There were no acute grade 3 toxicities related to proton therapy. Late grade 3 gastrointestinal toxicity and pulmonary toxicity each occurred in 1 patient. Conclusions: Dose-escalated proton therapy with concurrent chemotherapy was well tolerated with encouraging results among a small cohort of patients. Unfortunately, single-institution proton studies may be difficult to accrue and consideration for pragmatic and/or multicenter trial design should be considered when developing future proton clinical trials.« less

  7. Endoscopic spray cryotherapy for esophageal cancer: safety and efficacy.

    PubMed

    Greenwald, Bruce D; Dumot, John A; Abrams, Julian A; Lightdale, Charles J; David, Donald S; Nishioka, Norman S; Yachimski, Patrick; Johnston, Mark H; Shaheen, Nicholas J; Zfass, Alvin M; Smith, Jenny O; Gill, Kanwar Rupinder S; Burdick, J Steven; Mallat, Damien; Wolfsen, Herbert C

    2010-04-01

    Few options exist for patients with localized esophageal cancer ineligible for conventional therapies. Endoscopic spray cryotherapy with low-pressure liquid nitrogen has demonstrated efficacy in this setting in early studies. To assess the safety and efficacy of cryotherapy in esophageal carcinoma. Multicenter, retrospective cohort study. Ten academic and community medical centers between 2006 and 2009. Subjects with esophageal carcinoma in whom conventional therapy failed and those who refused or were ineligible for conventional therapy. Cryotherapy with follow-up biopsies. Treatment was complete when tumor eradication was confirmed by biopsy or when treatment was halted because of tumor progression, patient preference, or comorbid condition. Complete eradication of luminal cancer and adverse events. Seventy-nine subjects (median age 76 years, 81% male, 94% with adenocarcinoma) were treated. Tumor stage included T1-60, T2-16, and T3/4-3. Mean tumor length was 4.0 cm (range 1-15 cm). Previous treatment including endoscopic resection, photodynamic therapy, esophagectomy, chemotherapy, and radiation therapy failed in 53 subjects (67%). Forty-nine completed treatment. Complete response of intraluminal disease was seen in 31 of 49 subjects (61.2%), including 18 of 24 (75%) with mucosal cancer. Mean (standard deviation) length of follow-up after treatment was 10.6 (8.4) months overall and 11.5 (2.8) months for T1 disease. No serious adverse events were reported. Benign stricture developed in 10 (13%), with esophageal narrowing from previous endoscopic resection, radiotherapy, or photodynamic therapy noted in 9 of 10 subjects. Retrospective study design, short follow-up. Spray cryotherapy is safe and well tolerated for esophageal cancer. Short-term results suggest that it is effective in those who could not receive conventional treatment, especially for those with mucosal cancer. Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  8. 76 FR 17341 - Idaho Roadless Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... comment and/or met with the Shoshone-Paiute Tribes of Duck Valley, the Shoshone-Bannock Tribes of Fort...) included an eligibility study for Big Creek. The Agency's Record of Decision found Big Creek in-eligible... suitability study for the Secesh River, including Lake Creek. The Record of Decision found the Secesh River...

  9. Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial.

    PubMed

    Balar, Arjun V; Galsky, Matthew D; Rosenberg, Jonathan E; Powles, Thomas; Petrylak, Daniel P; Bellmunt, Joaquim; Loriot, Yohann; Necchi, Andrea; Hoffman-Censits, Jean; Perez-Gracia, Jose Luis; Dawson, Nancy A; van der Heijden, Michiel S; Dreicer, Robert; Srinivas, Sandy; Retz, Margitta M; Joseph, Richard W; Drakaki, Alexandra; Vaishampayan, Ulka N; Sridhar, Srikala S; Quinn, David I; Durán, Ignacio; Shaffer, David R; Eigl, Bernhard J; Grivas, Petros D; Yu, Evan Y; Li, Shi; Kadel, Edward E; Boyd, Zachary; Bourgon, Richard; Hegde, Priti S; Mariathasan, Sanjeev; Thåström, AnnChristine; Abidoye, Oyewale O; Fine, Gregg D; Bajorin, Dean F

    2017-01-07

    First-line chemotherapy for patients with cisplatin-ineligible locally advanced or metastatic urothelial carcinoma is associated with short response duration, poor survival, and high toxicity. This study assessed atezolizumab (anti-programmed death-ligand 1 [PD-L1]) as treatment for metastatic urothelial cancer in cisplatin-ineligible patients. For this single-arm, multicentre, phase 2 study, in 47 academic medical centres and community oncology practices in seven countries in North America and Europe, we recruited previously untreated patients with locally advanced or metastatic urothelial cancer who were cisplatin ineligible. Patients were given 1200 mg intravenous atezolizumab every 21 days until progression. The primary endpoint was independently confirmed objective response rate per Response Evaluation Criteria in Solid Tumors version 1.1 (central review), assessed in prespecified subgroups based on PD-L1 expression and in all patients. All participants who received one or more doses of atezolizumab were included in the primary and safety analyses. This study was registered with ClinicalTrials.gov, number NCT02108652. Between June 9, 2014, and March 30, 2015, we enrolled 123 patients, of whom 119 received one or more doses of atezolizumab. At 17·2 months' median follow-up, the objective response rate was 23% (95% CI 16 to 31), the complete response rate was 9% (n=11), and 19 of 27 responses were ongoing. Median response duration was not reached. Responses occurred across all PD-L1 and poor prognostic factor subgroups. Median progression-free survival was 2·7 months (2·1 to 4·2). Median overall survival was 15·9 months (10·4 to not estimable). Tumour mutation load was associated with response. Treatment-related adverse events that occurred in 10% or more of patients were fatigue (36 [30%] patients), diarrhoea (14 [12%] patients), and pruritus (13 [11%] patients). One treatment-related death (sepsis) occurred. Nine (8%) patients had an adverse event leading to treatment discontinuation. Immune-mediated events occurred in 14 (12%) patients. Atezolizumab showed encouraging durable response rates, survival, and tolerability, supporting its therapeutic use in untreated metastatic urothelial cancer. F Hoffmann-La Roche, Genentech. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Is transcatheter aortic valve implantation (TAVI) a cost-effective treatment in patients who are ineligible for surgical aortic valve replacement? A systematic review of economic evaluations.

    PubMed

    Eaton, James; Mealing, Stuart; Thompson, Juliette; Moat, Neil; Kappetein, Pieter; Piazza, Nicolo; Busca, Rachele; Osnabrugge, Ruben

    2014-05-01

    Health Technology Assessment (HTA) agencies often undertake a review of economic evaluations of an intervention during an appraisal in order to identify published estimates of cost-effectiveness, to elicit comparisons with the results of their own model, and to support local reimbursement decision-making. The aim of this research is to determine whether Transcatheter Aortic Valve Implantation (TAVI) compared to medical management (MM) is cost-effective in patients ineligible for surgical aortic valve replacement (SAVR), across different jurisdictions and country-specific evaluations. A systematic review of the literature from 2007-2012 was performed in the MEDLINE, MEDLINE in-process, EMBASE, and UK NHS EED databases according to standard methods, supplemented by a search of published HTA models. All identified publications were reviewed independently by two health economists. The British Medical Journal (BMJ) 35-point checklist for economic evaluations was used to assess study reporting. To compare results, incremental cost effectiveness ratios (ICERs) were converted to 2012 dollars using purchasing power parity (PPP) techniques. Six studies were identified representing five reimbursement jurisdictions (England/Wales, Scotland, the US, Canada, and Belgium) and different modeling techniques. The identified economic evaluations represent different willingness-to-pay thresholds, discount rates, medical costs, and healthcare systems. In addition, the model structures, time horizons, and cycle lengths varied. When adjusting for differences in currencies, the ICERs ranged from $27K-$65K per QALY gained. Despite notable differences in modeling approach, under the thresholds defined by using either the local threshold value or that recommended by the World Health Organization (WHO) threshold value, each study showed that TAVI was likely to be a cost-effective intervention for patients ineligible for SAVR.

  11. Emerging Role of Immunotherapy in Advanced Urothelial Carcinoma.

    PubMed

    Koshkin, Vadim S; Grivas, Petros

    2018-04-11

    Advanced urothelial carcinoma (aUC) has long been treated preferably with cisplatin-based chemotherapy, but many patients are cisplatin-ineligible whereas for those who progress on a platinum-based regimen treatment options are limited. We review key recent data regarding immune checkpoint inhibitors that are changing this treatment landscape. Since May 2016, five different agents targeting the PD-1/PD-L1 pathway (atezolizumab, pembrolizumab, nivolumab, avelumab, durvalumab) have received FDA approval for the treatment of aUC in the platinum-refractory setting, while pembrolizumab and atezolizumab are FDA-approved for cisplatin-ineligible patients in the first-line setting. Clinical outcomes and safety profiles of these agents appear relatively comparable across separate trials; however, only pembrolizumab is supported by level I evidence from a large randomized phase III trial showing overall survival benefit over conventional cytotoxic salvage chemotherapy in the platinum-refractory setting. Pembrolizumab has the highest level of evidence in platinum-refractory aUC, whereas pembrolizumab and atezolizumab have comparable level of evidence in the frontline setting in cisplatin-ineligible patients. Ongoing research is evaluating novel agents, various rational combinations, and sequences, as well as predictive and prognostic biomarkers.

  12. Disobedience and driving in patients with epilepsy.

    PubMed

    Tatum, W O; Worley, A V; Selenica, M L B

    2012-01-01

    Motor vehicle accidents direct legislators to ensure pubic safety. We attempted to characterize and quantify driving risk in patients with seizures (PWS). We delivered 12-question surveys to 287 consecutive PWS at an epilepsy clinic in Florida. Illegal and disobedient driving practices were analyzed. Eighty-three of 236 (35.2%) PWS were eligible to drive and 62.3% were ineligible with a seizure in <6 months (P<0.001, 95% CI: 0.57-0.70). Among the ineligible responders, 23.8% (35/147) of ineligible responders were illegally driving (14.83% of cohort); 11.86% (28/236) of PWS were disobedient refusing to obey the law, and 8.9% (21/236) of PWS were defiant and knew the law. Sadness (75/236, 31.8%) was the most common reaction to restriction, but disobedient PWS were angry (10/28, 35.7%). Overall, a small number of PWS are disobedient and illegally driving. A targeted approach to high-risk drivers with repeated verbal and supplemental driving information may help avoid unnecessary universal physician reporting for PWS. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. Government health insurance for people below poverty line in India: quasi-experimental evaluation of insurance and health outcomes

    PubMed Central

    Bendavid, Eran; Mukherji, Arnab; Wagner, Zachary; Nagpal, Somil; Mullen, Patrick

    2014-01-01

    Objectives To evaluate the effects of a government insurance program covering tertiary care for people below the poverty line in Karnataka, India, on out-of-pocket expenditures, hospital use, and mortality. Design Geographic regression discontinuity study. Setting 572 villages in Karnataka, India. Participants 31 476 households (22 796 below poverty line and 8680 above poverty line) in 300 villages where the scheme was implemented and 28 633 households (21 767 below poverty line and 6866 above poverty line) in 272 neighboring matched villages ineligible for the scheme. Intervention A government insurance program (Vajpayee Arogyashree scheme) that provided free tertiary care to households below the poverty line in about half of villages in Karnataka from February 2010 to August 2012. Main outcome measure Out-of-pocket expenditures, hospital use, and mortality. Results Among households below the poverty line, the mortality rate from conditions potentially responsive to services covered by the scheme (mostly cardiac conditions and cancer) was 0.32% in households eligible for the scheme compared with 0.90% among ineligible households just south of the eligibility border (difference of 0.58 percentage points, 95% confidence interval 0.40 to 0.75; P<0.001). We found no difference in mortality rates for households above the poverty line (households above the poverty line were not eligible for the scheme), with a mortality rate from conditions covered by the scheme of 0.56% in eligible villages compared with 0.55% in ineligible villages (difference of 0.01 percentage points, −0.03 to 0.03; P=0.95). Eligible households had significantly reduced out-of-pocket health expenditures for admissions to hospitals with tertiary care facilities likely to be covered by the scheme (64% reduction, 35% to 97%; P<0.001). There was no significant increase in use of covered services, although the point estimate of a 44.2% increase approached significance (−5.1% to 90.5%; P=0.059). Both reductions in out-of-pocket expenditures and potential increases in use might have contributed to the observed reductions in mortality. Conclusions Insuring poor households for efficacious but costly and underused health services significantly improves population health in India. PMID:25214509

  14. Treatment of gastric marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue with rituximab, cyclophosphamide, vincristine and prednisone.

    PubMed

    Aguiar-Bujanda, David; Llorca-Mártinez, Ignacio; Rivero-Vera, José C; Blanco-Sánchez, María J; Jiménez-Gallego, Pedro; Mori-De Santiago, Marta; Limeres-Gonzalez, Miguel A; Cabrera-Marrero, José C; Hernández-Sosa, María; Galván-Ruíz, Saray; Hernández-Sarmiento, Samuel; Saura Grau, Salvador; Bohn-Sarmiento, Uriel

    2014-09-01

    There is no standard treatment for patients with gastric marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) who are resistant to, or ineligible for, anti-Helicobacter pylori (anti-HP) therapy. In this study, we investigated the activity of the rituximab, cyclophosphamide, vincristine and prednisone (R-CVP) regimen in patients with gastric MALT lymphoma. Patients were included provided they had untreated gastric MALT lymphoma (except for anti-HP therapy) and were resistant to, or ineligible for, anti-HP therapy. Treatment plan consisted of six to eight 21-day cycles of the R-CVP chemotherapy regimen. Toxicity, response, relapse and survival were evaluated. Twenty patients (12 women and 8 men) were included in the analyses with median age of 59 years. Thirteen patients (65%) had stage I tumours, and seven patients (35%) had stages II-IV tumours. The overall response rate was 100%, with 19 (95%) complete responses and one (5%) partial response. Regimen toxicity was mild and mainly hematological, and no cases of gastric bleeding or perforation occurred. After a median follow-up of 56.3 months, three patients had relapsed, and 19 patients remained alive (specific lymphoma survival 100%), of whom 17 had no evidence of disease. In our experience, the R-CVP regimen is a well-tolerated and effective treatment for patients with gastric MALT lymphoma who are resistant to, or ineligible for, anti-HP therapy. Copyright © 2013 John Wiley & Sons, Ltd.

  15. 24 CFR 570.402 - Technical assistance awards.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... CFR part 571); and the Special Purpose Grants for Insular Areas, Community Development Work Study and... attended by more than one unit of government. (d) Eligible activities. Activities eligible for technical.... Activities for which costs are ineligible under this section include: (1) In the case of technical assistance...

  16. 24 CFR 570.402 - Technical assistance awards.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... CFR part 571); and the Special Purpose Grants for Insular Areas, Community Development Work Study and... attended by more than one unit of government. (d) Eligible activities. Activities eligible for technical.... Activities for which costs are ineligible under this section include: (1) In the case of technical assistance...

  17. Predictors of Poor School Readiness in Children Without Developmental Delay at Age 2

    PubMed Central

    Dudovitz, Rebecca N.; Coker, Tumaini R.; Barnert, Elizabeth S.; Biely, Christopher; Li, Ning; Szilagyi, Peter G.; Larson, Kandyce; Halfon, Neal; Zimmerman, Frederick J.; Chung, Paul J.

    2016-01-01

    BACKGROUND AND OBJECTIVES: Current recommendations emphasize developmental screening and surveillance to identify developmental delays (DDs) for referral to early intervention (EI) services. Many young children without DDs, however, are at high risk for poor developmental and behavioral outcomes by school entry but are ineligible for EI. We developed models for 2-year-olds without DD that predict, at kindergarten entry, poor academic performance and high problem behaviors. METHODS: Data from the Early Childhood Longitudinal Study, Birth Cohort (ECLS-B), were used for this study. The analytic sample excluded children likely eligible for EI because of DDs or very low birth weight. Dependent variables included low academic scores and high problem behaviors at the kindergarten wave. Regression models were developed by using candidate predictors feasibly obtainable during typical 2-year well-child visits. Models were cross-validated internally on randomly selected subsamples. RESULTS: Approximately 24% of all 2-year-old children were ineligible for EI at 2 years of age but still had poor academic or behavioral outcomes at school entry. Prediction models each contain 9 variables, almost entirely parental, social, or economic. Four variables were associated with both academic and behavioral risk: parental education below bachelor’s degree, little/no shared reading at home, food insecurity, and fair/poor parental health. Areas under the receiver-operating characteristic curve were 0.76 for academic risk and 0.71 for behavioral risk. Adding the mental scale score from the Bayley Short Form–Research Edition did not improve areas under the receiver-operating characteristic curve for either model. CONCLUSIONS: Among children ineligible for EI services, a small set of clinically available variables at age 2 years predicted academic and behavioral outcomes at school entry. PMID:27432845

  18. Early loss to follow-up of recently diagnosed HIV-infected adults from routine pre-ART care in a rural district hospital in Kenya: a cohort study.

    PubMed

    Hassan, Amin S; Fielding, Katherine L; Thuo, Nahashon M; Nabwera, Helen M; Sanders, Eduard J; Berkley, James A

    2012-01-01

    To determine the rate and predictors of early loss to follow-up (LTFU) for recently diagnosed HIV-infected, antiretroviral therapy (ART)-ineligible adults in rural Kenya. Prospective cohort study. Clients registering for HIV care between July 2008 and August 2009 were followed up for 6 months. Baseline data were used to assess predictors of pre-ART LTFU (not returning for care within 2 months of a scheduled appointment), LTFU before the second visit and LTFU after the second visit. Logistic regression was used to determine factors associated with LTFU before the second visit, while Cox regression was used to assess predictors of time to LTFU and LTFU after the second visit. Of 530 eligible clients, 178 (33.6%) were LTFU from pre-ART care (11.1/100 person-months). Of these, 96 (53.9%) were LTFU before the second visit. Distance (>5 km vs. <1 km: adjusted hazard ratio 2.6 [1.9-3.7], P < 0.01) and marital status (married vs. single: 0.5 [0.3-0.6], P < 0.01) independently predicted pre-ART LTFU. Distance and marital status were independently associated with LTFU before the second visit, while distance, education status and seasonality showed weak evidence of predicting LTFU after the second visit. HIV disease severity did not predict pre-ART LTFU. A third of recently diagnosed HIV-infected, ART-ineligible clients were LTFU within 6 months of registration. Predictors of LTFU among ART-ineligible clients are different from those among clients on ART. These findings warrant consideration of an enhanced pre-ART care package aimed at improving retention and timely ART initiation. © 2011 Blackwell Publishing Ltd.

  19. 45 CFR 1336.33 - Eligible applicants and proposed activities which are ineligible.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... served. (1) Social and Economic Development Strategies (SEDS) and Preservation and Enhancement of Native... 42 U.S.C. 2991b-3) (2) Alaska-Specific Social and Economic Development Strategies (SEDS) Projects: (i... carry out project objectives, is acceptable; (2) Projects that request funds for feasibility studies...

  20. 45 CFR 1336.33 - Eligible applicants and proposed activities which are ineligible.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... served. (1) Social and Economic Development Strategies (SEDS) and Preservation and Enhancement of Native... 42 U.S.C. 2991b-3) (2) Alaska-Specific Social and Economic Development Strategies (SEDS) Projects: (i... carry out project objectives, is acceptable; (2) Projects that request funds for feasibility studies...

  1. Cohort Default Rates: Predicting the Probability of Federal Sanctions

    ERIC Educational Resources Information Center

    Hillman, Nicholas W.

    2015-01-01

    This study examines the institutional factors associated with student loan default. When a college has more than 30% of its students default on their loans, then the institution faces federal sanctions that could make them ineligible from participating in the federal student loan program. Using Integrated Postsecondary Education Data System…

  2. Toward a patient-specific tissue engineered vascular graft

    PubMed Central

    Best, Cameron; Strouse, Robert; Hor, Kan; Pepper, Victoria; Tipton, Amy; Kelly, John; Shinoka, Toshiharu; Breuer, Christopher

    2018-01-01

    Integrating three-dimensional printing with the creation of tissue-engineered vascular grafts could provide a readily available, patient-specific, autologous tissue source that could significantly improve outcomes in newborns with congenital heart disease. Here, we present the recent case of a candidate for our tissue-engineered vascular graft clinical trial deemed ineligible due to complex anatomical requirements and consider the application of three-dimensional printing technologies for a patient-specific graft. We 3D-printed a closed-disposable seeding device and validated that it performed equivalently to the traditional open seeding technique using ovine bone marrow–derived mononuclear cells. Next, our candidate’s preoperative imaging was reviewed to propose a patient-specific graft. A seeding apparatus was then designed to accommodate the custom graft and 3D-printed on a commodity fused deposition modeler. This exploratory feasibility study represents an important proof of concept advancing progress toward a rationally designed patient-specific tissue-engineered vascular graft for clinical application. PMID:29568478

  3. Eligibility of Metastatic Pancreatic Cancer Patients for First-Line Palliative Intent nab-Paclitaxel Plus Gemcitabine Versus FOLFIRINOX.

    PubMed

    Peixoto, Renata D; Ho, Maria; Renouf, Daniel J; Lim, Howard J; Gill, Sharlene; Ruan, Jenny Y; Cheung, Winson Y

    2017-10-01

    The PRODIGE and MPACT trials showed superiority of FOLFIRINOX and nab-paclitaxel plus gemcitabine (NG) over gemcitabine alone, respectively. However, both had strict inclusion criteria. We sought to determine the characteristics of patients with metastatic pancreatic cancer (MPC) which inform the appropriateness of first-line chemotherapy FOLFIRINOX and NG in routine practice. Patients with MPC who initiated palliative chemotherapy with gemcitabine from 2000 to 2011 at the British Columbia Cancer Agency were identified. Clinicopathologic variables and outcomes were retrospectively collected and compared among groups. Eligibility criteria for each regimen were in accordance with the respective pivotal phase III trials. A total of 473 patients were included: 25% of the patients were eligible for FOLFIRINOX versus 45% for NG. Main reasons for FOLFIRINOX ineligibility were Eastern Cooperative Oncology Group (ECOG) performance status (PS)≥2 (56.5%), age older than 75 years (19.0%), and bilirubin>1.5× upper limit of normal (18.6%), whereas those for NG ineligibility were bilirubin > upper limit of normal (24.5%), ECOG PS≥3 (14.6%), and cardiac dysfunction (13.8%). Univariate analyses revealed that FOLFIRINOX and NG-eligible patients had longer median overall survival than their respective ineligible group (8.6 vs. 4.7 mo, P<0.001; 6.7 vs. 4.9 mo, P=0.008, respectively). After accounting for ECOG PS in the multivariate model, however, eligibility for either FOLFIRINOX or NG no longer predicted for better overall survival. The majority of patients with MPC are not candidates to either NG or FOLFIRINOX due to restrictive eligibility requirements. Specific trials addressing the unmet needs of protocol ineligible patients are warranted.

  4. Management of cryotherapy-ineligible women in a “screen-and-treat” cervical cancer prevention program targeting HIV-infected women in Zambia: Lessons from the field

    PubMed Central

    Pfaendler, Krista S.; Mwanahamuntu, Mulindi H.; Sahasrabuddhe, Vikrant V.; Mudenda, Victor; Stringer, Jeffrey S.A.; Parham, Groesbeck P.

    2009-01-01

    Objective We demonstrate the feasibility of implementing a referral and management system for cryotherapy-ineligible women in a “screen-and-treat” cervical cancer prevention program targeting HIV-infected women in Zambia. Methods We established criteria for patient referral, developed a training program for loop electrosurgical excision procedure (LEEP) providers, and adapted LEEP to a resource-constrained setting. Results We successfully trained 15 nurses to perform visual inspection with acetic acid (VIA) followed by immediate cryotherapy. Women with positive tests but ineligible for cryotherapy were referred for further evaluation. We trained four Zambian physicians to evaluate referrals, perform punch biopsy, LEEP, and manage intra-operative and post-operative complications. From January 2006 through October 2007, a total of 8823 women (41.5% HIV seropositive) were evaluated by nurses in outlying prevention clinics; of these, 1477 (16.7%) were referred for physician evaluation based on established criteria. Of the 875 (59.2% of 1147 referred) that presented for evaluation, 748 (8.4% of total screened) underwent histologic evaluation in the form of punch biopsy or LEEP. Complications associated with LEEP included anesthesia reaction (n=2) which spontaneously resolved, intra-operative (n=12) and post-operative (n=2) bleeding managed by local measures, and post-operative infection (n=12) managed with antibiotics. Conclusion With adaptations for a resource-constrained environment, we have demonstrated that performing LEEP is feasible and safe, with low rates of complications that can be managed locally. It is important to establish referral and management systems using LEEP-based excisional evaluation for women with cryotherapy-ineligible lesions in VIA-based “screen-and-treat” protocols nested within HIV-care programs in resource-constrained settings. PMID:18556050

  5. Management of cryotherapy-ineligible women in a "screen-and-treat" cervical cancer prevention program targeting HIV-infected women in Zambia: lessons from the field.

    PubMed

    Pfaendler, Krista S; Mwanahamuntu, Mulindi H; Sahasrabuddhe, Vikrant V; Mudenda, Victor; Stringer, Jeffrey S A; Parham, Groesbeck P

    2008-09-01

    We demonstrate the feasibility of implementing a referral and management system for cryotherapy-ineligible women in a "screen-and-treat" cervical cancer prevention program targeting HIV-infected women in Zambia. We established criteria for patient referral, developed a training program for loop electrosurgical excision procedure (LEEP) providers, and adapted LEEP to a resource-constrained setting. We successfully trained 15 nurses to perform visual inspection with acetic acid (VIA) followed by immediate cryotherapy. Women with positive tests but ineligible for cryotherapy were referred for further evaluation. We trained four Zambian physicians to evaluate referrals, perform punch biopsy, LEEP, and manage intra-operative and post-operative complications. From January 2006 through October 2007, a total of 8823 women (41.5% HIV seropositive) were evaluated by nurses in outlying prevention clinics; of these, 1477 (16.7%) were referred for physician evaluation based on established criteria. Of the 875 (59.2% of 1147 referred) that presented for evaluation, 748 (8.4% of total screened) underwent histologic evaluation in the form of punch biopsy or LEEP. Complications associated with LEEP included anesthesia reaction (n=2) which spontaneously resolved, intra-operative (n=12) and post-operative (n=2) bleeding managed by local measures, and post-operative infection (n=12) managed with antibiotics. With adaptations for a resource-constrained environment, we have demonstrated that performing LEEP is feasible and safe, with low rates of complications that can be managed locally. It is important to establish referral and management systems using LEEP-based excisional evaluation for women with cryotherapy-ineligible lesions in VIA-based "screen-and-treat" protocols nested within HIV-care programs in resource-constrained settings.

  6. Characterizing Disease Burden and Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration.

    PubMed

    Chakravarthy, Usha; Bailey, Clare C; Johnston, Robert L; McKibbin, Martin; Khan, Rehna S; Mahmood, Sajjad; Downey, Louise; Dhingra, Narendra; Brand, Christopher; Brittain, Christopher J; Willis, Jeffrey R; Rabhi, Sarah; Muthutantri, Anushini; Cantrell, Ronald A

    2018-06-01

    To understand levels of disease burden and progression in a real-world setting among patients from the United Kingdom with bilateral geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Retrospective cohort analysis of a multicenter electronic medical record (EMR) database. Patients who were aged ≥50 years with bilateral GA and no history of choroidal neovascularization (CNV) and who attended 1 of 10 clinical sites using the EMR. A deidentified data set was constructed from the records held at the 10 sites. An algorithm was used to extract cases with a GA diagnosis, of which 1901 had bilateral GA and form the basis of this report. A sample of records randomly selected from each center was used to validate disease definitions. Progression to blindness (visual acuity [VA] <20 letters or Snellen 3/60 in the better-seeing eye), driving ineligibility (VA ≤70 letters or Snellen 6/12 in the better-seeing eye), progression to CNV, loss of 10 or more letters, and mean change in VA over time. At first record of GA, 7.1% had a VA in the better-seeing eye equal to or lower than the cutoff for blindness registration and 71.1% had a VA that would have rendered them ineligible to drive. Over time, 16% became legally blind (median time to outcome, 6.2 years) and 66.7% became ineligible to drive (median time to outcome, 1.6 years). In the worse-seeing eye, 40.1% lost ≥10 letters in 2.4 years. Among patients with baseline and 24-month VA measurements, mean VA decline was 6.1 letters in the worse-seeing eye (n = 413) and 12.4 letters in the better-seeing eye (n = 414). The rate of progression to CNV in either eye was 7.4% per patient-year. At initial diagnosis, based on VA in the better-seeing eye, a high proportion of patients with bilateral GA were ineligible to drive and approximately 7% were eligible for UK blindness registration. The subsequent reduction in VA that occurred in the better-seeing eye would render a further two-thirds ineligible to drive. These findings emphasize the severity of the visual disability associated with GA secondary to AMD. Copyright © 2018 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  7. First-Line Atezolizumab Effective in Bladder Cancer.

    PubMed

    2016-08-01

    Results from a phase II study indicate that the PD-L1 inhibitor atezolizumab, recently approved for advanced bladder cancer that's refractory to standard platinum chemotherapy, is effective as first-line therapy for this disease. Durable responses to atezolizumab were seen in nearly a quarter of the study patients, who were all ineligible to receive cisplatin. ©2016 American Association for Cancer Research.

  8. The Athlete and the Grade Change

    ERIC Educational Resources Information Center

    Robinson, Tina I.; Skinner, Tracy

    2008-01-01

    This case study focuses on the moral and ethical issues surrounding changing an athlete's grade to make him eligible to play in a championship game. Jerome, a senior attending Woodrow Wilson High School, earned a D in his typing class, which made him ineligible to play in the basketball championship games. The principal and basketball coach made…

  9. The Reality of Longitudinal Data Collection: Locating Vanishing Veterans.

    ERIC Educational Resources Information Center

    Camara, Wayne J.; And Others

    This paper investigates the utility of various procedures used to locate and interview veterans as part of a longitudinal research study being conducted for the Department of Defense. The populations are comprised of below entry aptitude standards males who entered the military during the late 1960s, and potentially ineligibles who entered between…

  10. American Indians and Vocational Rehabilitation: A Case Review Study of Former Clients.

    ERIC Educational Resources Information Center

    Frank, Lyle W.

    A review of 80 case files of American Indians in Northern Arizona was undertaken to identify factors associated with clients who were found to be ineligible for rehabilitation services and clients who were successfully and unsuccessfully rehabilitated. The 11 dependent variables considered were severity of disability, physical or mental…

  11. 34 CFR 600.7 - Conditions of institutional ineligibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... than fifty percent of its regular enrolled students had neither a high school diploma nor the recognized equivalent of a high school diploma, and the institution does not provide a four-year or two-year... high school and who are available for study in preparation for entering the labor market” under section...

  12. Socioeconomic and gender group differences in early literacy skills: a multiple-group confirmatory factor analysis approach

    PubMed Central

    Lee, Julia Ai Cheng; Otaiba, Stephanie Al

    2015-01-01

    Socioeconomic status and gender are important demographic variables that strongly relate to academic achievement. This study examined the early literacy skills differences between 4 sociodemographic groups, namely, boys ineligible for free or reduced-price lunch (FRL), girls ineligible for FRL, boys eligible for FRL, and girls eligible for FRL. Data on kindergarteners (N = 462) were analysed using multiple-group confirmatory factory analysis. Early literacy skill differences between boys and girls are more nuanced than previously reported; subsidy status and gender interact. Both boys and girls from high-poverty households performed significantly lower than the girls from low-poverty households in alphabet knowledge, phonological awareness, and spelling. There were gender gaps, with a female advantage, among children from high-poverty households in alphabet knowledge and spelling and among children from low-poverty households in alphabet knowledge. These results highlight the importance of employing methodologically sound techniques to ascertain group differences in componential early literacy skills. PMID:25750582

  13. Heart failure disease management program experience in 4,545 heart failure admissions to a community hospital.

    PubMed

    Pazin-Filho, Antonio; Peitz, Pamela; Pianta, Thomas; Carson, Kathryn A; Russell, Stuart D; Boulware, Leigh Ebony; Coresh, Josef

    2009-09-01

    Disease management programs (DMPs) are developed to address the high morbi-mortality and costs of congestive heart failure (CHF). Most studies have focused on intensive programs in academic centers. Washington County Hospital (WCH) in Hagerstown, MD, the primary reference to a semirural county, established a CHF DMP in 2001 with standardized documentation of screening and participation. Linkage to electronic records and state vital statistics enabled examination of the CHF population including individuals participating and those ineligible for the program. All WCH inpatients with CHF International Classification of Diseases, Ninth Revision code in any position of the hospital list discharged alive. Of 4,545 consecutive CHF admissions, only 10% enrolled and of those only 52.2% made a call. Enrollment in the program was related to: age (OR 0.64 per decade older, 95% CI 0.58-0.70), CHF as the main reason for admission (OR 3.58, 95% CI 2.4-4.8), previous admission for CHF (OR 1.14, 95% CI 1.09-1.2), and shorter hospital stay (OR 0.94 per day longer, 95% CI 0.87-0.99). Among DMP participants mortality rates were lowest in the first month (80/1000 person-years) and increased subsequently. The opposite mortality trend occurred in nonenrolled groups with mortality in the first month of 814 per 1000 person-years in refusers and even higher in ineligible (1569/1000 person-years). This difference remained significant after adjustment. Re-admission rates were lower among participants who called consistently (adjusted incidence rate ratio 0.62, 95% CI 0.52-0.77). Only a small and highly select group participated in a low-intensity DMP for CHF in a community-based hospital. Design of DMPs should incorporate these strong selective factors to maximize program impact.

  14. Lessons for Successful Study Enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study

    PubMed Central

    Crowley, Susan T.; Chertow, Glenn M.; Vitale, Joseph; O'Connor, Theresa; Zhang, Jane; Schein, Roland M.H.; Choudhury, Devasmita; Finkel, Kevin; Vijayan, Anitha; Paganini, Emil; Palevsky, Paul M.

    2008-01-01

    Background and objectives: Design elements of clinical trials can introduce recruitment bias and reduce study efficiency. Trials involving the critically ill may be particularly prone to design-related inefficiencies. Design, setting, participants, & measurements: Enrollment into the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study was systematically monitored. Reasons for nonenrollment into this study comparing strategies of renal replacement therapy in critically ill patients with acute kidney injury were categorized as modifiable or nonmodifiable. Results: 4339 patients were screened; 2744 fulfilled inclusion criteria. Of these, 1034 were ineligible by exclusion criteria. Of the remaining 1710 patients, 1124 (65.7%) enrolled. Impediments to informed consent excluded 21.4% of potentially eligible patients. Delayed identification of potential patients, physician refusal, and involvement in competing trials accounted for 4.4, 2.7, and 2.3% of exclusions. Comfort measures only status, chronic illness, chronic kidney disease, and obesity excluded 11.8, 7.8, 7.6, and 5.9% of potential patients. Modification of an enrollment window reduced the loss of patients from 6.6 to 2.3%. Conclusions: The Acute Renal Failure Trial Network Study's enrollment efficiency compared favorably with previous intensive care unit intervention trials and supports the representativeness of its enrolled population. Impediments to informed consent highlight the need for nontraditional acquisition methods. Restrictive enrollment windows may hamper recruitment but can be effectively modified. The low rate of physician refusal acknowledges clinical equipoise in the study design. Underlying comorbidities are important design considerations for future trials that involve the critically ill with acute kidney injury. PMID:18385390

  15. The effects of reasons given for ineligibility on perceived gender discrimination and feelings of injustice.

    PubMed

    Kappen, D M; Branscombe, N R

    2001-06-01

    We examine whether the reason given for a negative outcome influences the likelihood of making gender discrimination attributions. Men and women were given one of four reasons for their ineligibility to attend an event: an explicit gender reason, a reason based on an attribute correlated with gender, that same gender-related reason with explanatory information attached, or they were given no reason. Providing participants with a reason based on a gender-related attribute deflected them from making attributions to gender discrimination, indicating that discrimination attributions can easily be averted. Adding explanatory information to the gender-related reason decreased feelings of injustice, illegitimacy and anger while increasing acceptance of the outcome.

  16. Eligibility for isoniazid preventive therapy in South African gold mines.

    PubMed

    Lewis, James J; Fielding, Katherine L; Grant, Alison D; Chihota, Violet N; Popane, Flora; Luttig, Mariette; Muller, Dorothy; Coetzee, Leonie; Churchyard, Gavin J

    2013-01-01

    The "Thibela TB" cluster randomised trial of community-wide isoniazid preventive therapy (IPT) to reduce tuberculosis incidence in the South African gold mines. To determine the proportion of participants eligible for IPT and the reasons and risk factors for ineligibility, to inform the scale-up of IPT. Cross-sectional survey of participants in intervention clusters (mine shafts) consenting to tuberculosis screening and assessment for eligibility to start IPT. Among 27,126 consenting participants, 94.7% were male, the median age was 41 years, 12.2% reported previous tuberculosis, 0.6% reported ever taking IPT and 2.5% reported currently taking antiretroviral therapy. There were 24,430 (90.1%) assessed as eligible to start IPT, of whom 23,659 started IPT. The most common reasons for ineligibility were having suspected tuberculosis that was subsequently confirmed by a positive smear and/or culture (n=705), excessive alcohol consumption (n=427) and being on tuberculosis treatment at time of initial screen (n=241). Ineligibility was associated with factors including older age, female gender, prior history of tuberculosis and being in "HIV care". However, at least 78% were eligible for IPT in all of these sub-groups. The vast majority of participants in this community-wide intervention were eligible for IPT.

  17. Low power vs standard power transpupillary thermotherapy in patients with age-related macular degeneration and subfoveal choroidal neovascularization ineligible for photodynamic therapy.

    PubMed

    Hogan, A C; Kilmartin, D J

    2006-06-01

    To assess the effect of standard power vs low power transpupillary thermotherapy (TTT) in patients with active subfoveal choroidal neovascularization secondary to age-related macular degeneration ineligible for photodynamic therapy (PDT) by original treatment of age-related macular degeneration with photodynamic therapy (TAP) study group recommendations. Retrospective review of 79 patients with active predominantly occult subfoveal choroidal neovascularization or predominantly classic subfoveal choroidal neovascularization but Snellen visual acuity <20/200. All patients were treated with TTT administered via a Mainster wide field fundus contact lens with a retinal power/diameter coefficient of 248 mW/mm in the standard power (n=27) and 181 mW/mm in the low power group (n=52). The primary outcome was stabilization (<1 Snellen line change) or improvement (two or more Snellen lines) in visual acuity. Clinical and fluorescein angiographic resolution of overlying exudation was documented. At 24 month follow-up, 17 patients (63%) in the standard power and 36 patients (69%) in the low power group achieved stable or improved vision. Improved vision (mean three lines) was observed in 22% of the standard power and 23% of the low power group. Overlying exudation was reduced clinically with minimal or no leakage on fluorescein angiogram in 85% of standard power and 90% of low power group. Subgroup analysis in the low power group demonstrated a visual benefit in patients with subfoveal lesions, which had any classic component. Low power TTT is as effective as standard power in stabilizing or improving vision and reducing overlying exudation in patients with active subfoveal choroidal neovascularization ineligible for PDT.

  18. A Pilot Study to Estimate the Cost of a Telephone Survey of Rare Populations: African Americans and Persons with Angina.

    ERIC Educational Resources Information Center

    Bertram, Dennis A.

    1994-01-01

    This pilot study provides information on the effort required to conduct a telephone survey on access to care of persons with angina. Allowing for noncontact calls, refusal to participate, and ineligibility, the response rate for whites was 23.4% (2,724 of 11,559), and that of African Americans was 24.3% (2,003 of 8,242). (SLD)

  19. 24 CFR 1003.207 - Ineligible activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT COMMUNITY DEVELOPMENT BLOCK GRANTS FOR INDIAN TRIBES AND ALASKA NATIVE VILLAGES Eligible... repair of streets, parks, playgrounds, water and sewer facilities, neighborhood facilities, senior...

  20. Old age pension and intergenerational living arrangements: a regression discontinuity design

    PubMed Central

    2017-01-01

    China launched a pension program for rural residents in 2009, now covering more than 300 million Chinese. This program offers a unique setting for studying the ageing population, given the rapidity of China’s population ageing, traditions of filial piety and co-residence, decreasing number of children, and dearth of formal social security, at a relatively low income level. This paper examines whether receipt of the old-age pension payment equips elderly parents and their adult children to live apart and whether parents substitute children’s time involved in instrumental support to them with service consumption. Employing a regression discontinuity design to a primary longitudinal survey conducted in Guizhou province of China, this paper overcomes challenges in the literature that households eligible for pension payment might be systematically different from ineligible households and that it is difficult to separate the effect of pension from that of age or cohort heterogeneity. Around the pension eligibility age cut-off, results reveal large and significant reduction in intergenerational co-residence of the extended family and increase in service consumption among elderly parents. PMID:29051720

  1. 42 CFR 62.3 - Who is eligible to apply for a scholarship program award?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... enrollment, or be enrolled, as a full-time student in a school located in a State; (2) Be pursuing a course of study or program offered by the school leading to a degree in medicine, osteopathy, dentistry, or... under this part is ineligible for an award unless a written statement satisfactory to the Secretary is...

  2. Lessons for successful study enrollment from the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study.

    PubMed

    Crowley, Susan T; Chertow, Glenn M; Vitale, Joseph; O'Connor, Theresa; Zhang, Jane; Schein, Roland M H; Choudhury, Devasmita; Finkel, Kevin; Vijayan, Anitha; Paganini, Emil; Palevsky, Paul M

    2008-07-01

    Design elements of clinical trials can introduce recruitment bias and reduce study efficiency. Trials involving the critically ill may be particularly prone to design-related inefficiencies. Enrollment into the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network Study was systematically monitored. Reasons for nonenrollment into this study comparing strategies of renal replacement therapy in critically ill patients with acute kidney injury were categorized as modifiable or nonmodifiable. 4339 patients were screened; 2744 fulfilled inclusion criteria. Of these, 1034 were ineligible by exclusion criteria. Of the remaining 1710 patients, 1124 (65.7%) enrolled. Impediments to informed consent excluded 21.4% of potentially eligible patients. Delayed identification of potential patients, physician refusal, and involvement in competing trials accounted for 4.4, 2.7, and 2.3% of exclusions. Comfort measures only status, chronic illness, chronic kidney disease, and obesity excluded 11.8, 7.8, 7.6, and 5.9% of potential patients. Modification of an enrollment window reduced the loss of patients from 6.6 to 2.3%. The Acute Renal Failure Trial Network Study's enrollment efficiency compared favorably with previous intensive care unit intervention trials and supports the representativeness of its enrolled population. Impediments to informed consent highlight the need for nontraditional acquisition methods. Restrictive enrollment windows may hamper recruitment but can be effectively modified. The low rate of physician refusal acknowledges clinical equipoise in the study design. Underlying comorbidities are important design considerations for future trials that involve the critically ill with acute kidney injury.

  3. 50 CFR 80.54 - What activities are ineligible for funding?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible...

  4. 50 CFR 80.54 - What activities are ineligible for funding?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible...

  5. Trial Prospector: Matching Patients with Cancer Research Studies Using an Automated and Scalable Approach

    PubMed Central

    Sahoo, Satya S; Tao, Shiqiang; Parchman, Andrew; Luo, Zhihui; Cui, Licong; Mergler, Patrick; Lanese, Robert; Barnholtz-Sloan, Jill S; Meropol, Neal J; Zhang, Guo-Qiang

    2014-01-01

    Cancer is responsible for approximately 7.6 million deaths per year worldwide. A 2012 survey in the United Kingdom found dramatic improvement in survival rates for childhood cancer because of increased participation in clinical trials. Unfortunately, overall patient participation in cancer clinical studies is low. A key logistical barrier to patient and physician participation is the time required for identification of appropriate clinical trials for individual patients. We introduce the Trial Prospector tool that supports end-to-end management of cancer clinical trial recruitment workflow with (a) structured entry of trial eligibility criteria, (b) automated extraction of patient data from multiple sources, (c) a scalable matching algorithm, and (d) interactive user interface (UI) for physicians with both matching results and a detailed explanation of causes for ineligibility of available trials. We report the results from deployment of Trial Prospector at the National Cancer Institute (NCI)-designated Case Comprehensive Cancer Center (Case CCC) with 1,367 clinical trial eligibility evaluations performed with 100% accuracy. PMID:25506198

  6. 50 CFR 80.54 - What activities are ineligible for funding?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE AND SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible...

  7. 50 CFR 80.54 - What activities are ineligible for funding?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE AND SPORT FISH RESTORATION PROGRAM ADMINISTRATIVE REQUIREMENTS, PITTMAN-ROBERTSON WILDLIFE RESTORATION AND DINGELL-JOHNSON SPORT FISH RESTORATION ACTS Eligible...

  8. 48 CFR 2009.470 - Appeals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 2009.470 Appeals. A... for Operations. A copy of the notice of appeal must be furnished to the debarring/suspending official. ...

  9. Women's ability to self-screen for contraindications to combined oral contraceptive pills in Tanzanian drug shops.

    PubMed

    Chin-Quee, Dawn; Ngadaya, Esther; Kahwa, Amos; Mwinyiheri, Thomas; Otterness, Conrad; Mfinanga, Sayoki; Nanda, Kavita

    2013-10-01

    To estimate the accuracy of self-screening for contraindications to combined oral contraceptive pills (COCs) and to estimate the proportion of women with contraindications to hormonal methods among those using drug shops in Tanzania. Trained nurses interviewed 1651 women aged 18-39 years who self-screened for contraindications to COCs with the help of a poster at drug shops in Tanzania. Nurse assessment of the women served as the gold standard for comparison with self-assessment. Blood pressure was also measured onsite. Nurses reported that 437 (26.5%) women were not eligible to use COCs, compared with 485 (29.4%) according to self-report. Overall, 133 (8.1%) women who said that they were eligible were deemed ineligible by nurses. The rate of ineligibility was artificially high owing to participant and nurse assessments that were incorrectly based on adverse effects of pill use and cultural reasons, and because of the sampling procedure, which intercepted women regardless of their reasons for visiting the drug shop. Adjusted rates of ineligibility were 8.6% and 12.7%, respectively, according to nurse and participant assessment. Both nurses and women underestimated the prevalence of hypertension in the present group. Self-screening among women in rural and peri-urban Tanzania with regard to contraindications to COC use was comparable to assessment by trained nurses. © 2013.

  10. Income-related disparities in kidney transplant graft failures are eliminated by Medicare's immunosuppression coverage

    PubMed Central

    Woodward, Robert S.; Page, Timothy F.; Soares, Ricardo; Schnitzler, Mark A.; Lentine, Krista L.; Brennan, Daniel C.

    2011-01-01

    Beginning January 1, 2000, Medicare extended coverage of immunosuppression medications from 3-years to lifetime based on age >65 years or disability. Using USRDS data for Medicare-insured recipients of kidney transplants between July 1995 and December 2000, we identified four Cohorts of Medicare-insured kidney transplant recipients. Patients in Cohort 1 were individuals who were both eligible and received lifetime-coverage. Patients in Cohort 2 would have been eligible, but their three-year coverage expired before lifetime-coverage was available. Patients in Cohort 3 were ineligible for lifetime-coverage because of youth or lack of disability. Patients in Cohort 4 were transplanted 1996–1996 and were ineligible for lifetime-coverage. Incomes were categorized by ZIP-code median household income from census data. Lifetime-extension of Medicare immunosuppression was associated with improved allograft survival among low-income transplant recipients in the sense that the previously existing income-related disparities in graft survival in Cohort 2 were not apparent in Cohort 1. Ineligible individuals served as a control group; the income-related disparities in graft survival observed in the early Cohort 4 persisted in more recent Cohort 3. Multivariate proportional-hazards models confirmed these findings. Future work should evaluate the cost-effectiveness of these coverage increases, as well as that of benefits extensions to broader patient groups. PMID:19032227

  11. 24 CFR 5.524 - Compliance with nondiscrimination requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the restrictions on use of assisted housing by noncitizens with ineligible immigration status imposed by this part in conformity with all applicable nondiscrimination and equal opportunity requirements...

  12. Non-U.S. Citizen, Community College Students: Their Federal Student Aid Status, Gender, Achievement, and Persistence at an Emerging HSI

    ERIC Educational Resources Information Center

    Sanchez, Jafeth E.; Smith, Jeannette

    2017-01-01

    This study presents a quantitative, exploratory analysis of 535 students attending Truckee Meadows Community College in Northern Nevada who were eligible or ineligible for federal student aid and were non-U.S. citizens. Within a snapshot of the Fall 2015 through Fall 2016 semesters, we examined the variables of gender, grade point average (GPA),…

  13. 38 CFR 21.216 - Special equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... aids to closed-circuit TV systems which amplify reading material for veterans with severe visual.... The veteran must be found ineligible for needed special equipment under other programs and benefits...

  14. 38 CFR 21.216 - Special equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... aids to closed-circuit TV systems which amplify reading material for veterans with severe visual.... The veteran must be found ineligible for needed special equipment under other programs and benefits...

  15. 38 CFR 21.216 - Special equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... aids to closed-circuit TV systems which amplify reading material for veterans with severe visual.... The veteran must be found ineligible for needed special equipment under other programs and benefits...

  16. 38 CFR 21.216 - Special equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... aids to closed-circuit TV systems which amplify reading material for veterans with severe visual.... The veteran must be found ineligible for needed special equipment under other programs and benefits...

  17. 48 CFR 1309.407-1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 1309.407-1 General... forth in CAM 1301.70 states in writing compelling reasons for continuing to do business with a suspended...

  18. 7 CFR 247.15 - Notification of eligibility or ineligibility of applicant.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD... program standards are applied without discrimination by race, color, national origin, age, sex, or...

  19. 7 CFR 247.15 - Notification of eligibility or ineligibility of applicant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD... program standards are applied without discrimination by race, color, national origin, age, sex, or...

  20. 7 CFR 247.15 - Notification of eligibility or ineligibility of applicant.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD... program standards are applied without discrimination by race, color, national origin, age, sex, or...

  1. 7 CFR 247.15 - Notification of eligibility or ineligibility of applicant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD... program standards are applied without discrimination by race, color, national origin, age, sex, or...

  2. 7 CFR 247.15 - Notification of eligibility or ineligibility of applicant.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD... program standards are applied without discrimination by race, color, national origin, age, sex, or...

  3. 48 CFR 1409.405 - Effect of listing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 1409.405 Effect of listing. When a CO finds that a compelling reason exists to conduct business with a contractor listed on...

  4. 44 CFR 361.8 - Ineligible expenditures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for the purchase or rental of any equipment such as radio/telephone communications equipment, warning systems, and computers and other related information processing equipment, except as stated in § 361.7(b...

  5. 44 CFR 361.8 - Ineligible expenditures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... for the purchase or rental of any equipment such as radio/telephone communications equipment, warning systems, and computers and other related information processing equipment, except as stated in § 361.7(b...

  6. 44 CFR 361.8 - Ineligible expenditures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for the purchase or rental of any equipment such as radio/telephone communications equipment, warning systems, and computers and other related information processing equipment, except as stated in § 361.7(b...

  7. 44 CFR 361.8 - Ineligible expenditures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... for the purchase or rental of any equipment such as radio/telephone communications equipment, warning systems, and computers and other related information processing equipment, except as stated in § 361.7(b...

  8. 44 CFR 361.8 - Ineligible expenditures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... for the purchase or rental of any equipment such as radio/telephone communications equipment, warning systems, and computers and other related information processing equipment, except as stated in § 361.7(b...

  9. 7 CFR 4284.921 - Ineligible applicants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Value-Added Producer Grant Program Eligibility... Federal Court (other than U.S. Tax Court), is delinquent on the payment of Federal income taxes, or is...

  10. 7 CFR 4284.921 - Ineligible applicants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Value-Added Producer Grant Program Eligibility... Federal Court (other than U.S. Tax Court), is delinquent on the payment of Federal income taxes, or is...

  11. 7 CFR 4284.921 - Ineligible applicants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Value-Added Producer Grant Program Eligibility... Federal Court (other than U.S. Tax Court), is delinquent on the payment of Federal income taxes, or is...

  12. Reasons for Ineligibility in Phase 1 and 2A HIV Vaccine Clinical Trials at Kenya Aids Vaccine Initiative (KAVI), Kenya

    PubMed Central

    Omosa-Manyonyi, Gloria S.; Jaoko, Walter; Anzala, Omu; Ogutu, Hilda; Wakasiaka, Sabina; Malogo, Roselyn; Nyange, Jacqueline; Njuguna, Pamela; Ndinya-Achola, Jeckoniah; Bhatt, Kirana; Farah, Bashir; Oyaro, Micah; Schmidt, Claudia; Priddy, Frances; Fast, Patricia

    2011-01-01

    Background With the persistent challenges towards controlling the HIV epidemic, there is an ongoing need for research into HIV vaccines and drugs. Sub-Saharan African countries - worst affected by the HIV pandemic - have participated in the conduct of clinical trials for HIV vaccines. In Kenya, the Kenya AIDS Vaccine Initiative (KAVI) at the University of Nairobi has conducted HIV vaccine clinical trials since 2001. Methodology Participants were recruited after an extensive informed consent process followed by screening to determine eligibility. Screening included an assessment of risk behavior, medical history and physical examination, and if clinically healthy, laboratory testing. In the absence of locally derived laboratory reference ranges, the ranges used in these trials were derived from populations in the West. Principal findings Two hundred eighty-one participants were screened between 2003 and 2006 for two clinical trials. Of these, 167 (59.4%) met the inclusion/exclusion criteria. Overall, laboratory abnormalities based on the non-indigenous laboratory references used were the most frequent reasons (61.4%) for ineligibility. Medical abnormalities contributed 30.7% of the total reasons for ineligibility. Based on the laboratory reference intervals now developed from East and Southern Africa, those ineligible due to laboratory abnormalities would have been 46.3%. Of the eligible participants, 18.6% declined enrolment. Conclusions Participant recruitment for HIV vaccine clinical trials is a rigorous and time-consuming exercise. Over 61% of the screening exclusions in clinically healthy people were due to laboratory abnormalities. It is essential that laboratory reference ranges generated from local populations for laboratory values be used in the conduct of clinical trials to avoid unnecessary exclusion of willing participants and to avoid over-reporting of adverse events for enrolled participants. Trial registration Protocol IAVI VRC V001 [1]. ClinicalTrials.gov NCT00124007 Protocol IAVI 010 [2] (registration with ClincalTrials.gov is in progress) Protocols IAVI 002 and IAVI 004 are Phase 1 trials only mentioned in introductory paragraphs; details will not be reported. Registration was not required when they were conducted. PMID:21283743

  13. Left atrial appendage closure with the Watchman device in patients with a contraindication for oral anticoagulation: the ASAP study (ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology).

    PubMed

    Reddy, Vivek Y; Möbius-Winkler, Sven; Miller, Marc A; Neuzil, Petr; Schuler, Gerhard; Wiebe, Jens; Sick, Peter; Sievert, Horst

    2013-06-25

    The purpose of this study was to assess the safety and efficacy of left atrial appendage (LAA) closure in nonvalvular atrial fibrillation (AF) patients ineligible for warfarin therapy. The PROTECT AF (Watchman Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation) trial demonstrated that LAA closure with the Watchman device (Boston Scientific, Natick, Massachusetts) was noninferior to warfarin therapy. However, the PROTECT AF trial only included patients who were candidates for warfarin, and even patients randomly assigned to the LAA closure arm received concomitant warfarin for 6 weeks after Watchman implantation. A multicenter, prospective, nonrandomized study was conducted of LAA closure with the Watchman device in 150 patients with nonvalvular AF and CHADS₂ (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, and prior stroke or transient ischemic attack) score ≥1, who were considered ineligible for warfarin. The primary efficacy endpoint was the combined events of ischemic stroke, hemorrhagic stroke, systemic embolism, and cardiovascular/unexplained death. The mean CHADS₂ score and CHA₂DS₂-VASc (CHADS₂ score plus 2 points for age ≥75 years and 1 point for vascular disease, age 65 to 74 years, or female sex) score were 2.8 ± 1.2 and 4.4 ± 1.7, respectively. History of hemorrhagic/bleeding tendencies (93%) was the most common reason for warfarin ineligibility. Mean duration of follow-up was 14.4 ± 8.6 months. Serious procedure- or device-related safety events occurred in 8.7% of patients (13 of 150 patients). All-cause stroke or systemic embolism occurred in 4 patients (2.3% per year): ischemic stroke in 3 patients (1.7% per year) and hemorrhagic stroke in 1 patient (0.6% per year). This ischemic stroke rate was less than that expected (7.3% per year) based on the CHADS₂ scores of the patient cohort. LAA closure with the Watchman device can be safely performed without a warfarin transition, and is a reasonable alternative to consider for patients at high risk for stroke but with contraindications to systemic oral anticoagulation. (ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology [ASAP]; NCT00851578). Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  14. The Causal Effect of Student Mobility on Standardized Test Performance: A Case Study with Possible Implications for Accountability Mandates within the Elementary and Secondary Education Act.

    PubMed

    Selya, Arielle S; Engel-Rebitzer, Eden; Dierker, Lisa; Stephen, Eric; Rose, Jennifer; Coffman, Donna L; Otis, Mindy

    2016-01-01

    This paper presents a limited case study examining the causal inference of student mobility on standardized test performance, within one middle-class high school in suburban Connecticut. Administrative data were used from a district public high school enrolling 319 10th graders in 2010. Propensity score methods were used to estimate the causal effect of student mobility on Math, Science, Reading, and Writing portions of the Connecticut Academic Performance Test (CAPT), after matching mobile vs. stable students on gender, race/ethnicity, eligibility for free/reduced lunches, and special education status. Analyses showed that mobility was associated with lower performance in the CAPT Writing exam. Follow-up analyses revealed that this trend was only significant among those who were ineligible for free/reduced lunches, but not among eligible students. Additionally, mobile students who were ineligible for free/reduced lunches had lower performance in the CAPT Science exam according to some analyses. Large numbers of students transferring into a school district may adversely affect standardized test performance. This is especially relevant for policies that affect student mobility in schools, given the accountability measures in the No Child Left Behind that are currently being re-considered in the recent Every Student Succeeds Act.

  15. The Causal Effect of Student Mobility on Standardized Test Performance: A Case Study with Possible Implications for Accountability Mandates within the Elementary and Secondary Education Act

    PubMed Central

    Selya, Arielle S.; Engel-Rebitzer, Eden; Dierker, Lisa; Stephen, Eric; Rose, Jennifer; Coffman, Donna L.; Otis, Mindy

    2016-01-01

    This paper presents a limited case study examining the causal inference of student mobility on standardized test performance, within one middle-class high school in suburban Connecticut. Administrative data were used from a district public high school enrolling 319 10th graders in 2010. Propensity score methods were used to estimate the causal effect of student mobility on Math, Science, Reading, and Writing portions of the Connecticut Academic Performance Test (CAPT), after matching mobile vs. stable students on gender, race/ethnicity, eligibility for free/reduced lunches, and special education status. Analyses showed that mobility was associated with lower performance in the CAPT Writing exam. Follow-up analyses revealed that this trend was only significant among those who were ineligible for free/reduced lunches, but not among eligible students. Additionally, mobile students who were ineligible for free/reduced lunches had lower performance in the CAPT Science exam according to some analyses. Large numbers of students transferring into a school district may adversely affect standardized test performance. This is especially relevant for policies that affect student mobility in schools, given the accountability measures in the No Child Left Behind that are currently being re-considered in the recent Every Student Succeeds Act. PMID:27486427

  16. 7 CFR 1944.520 - Ineligible activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... financial support which would be available from any other source. (3) Duplication of current services in conflict with the requirements of § 1944.514(c). (4) Hiring personnel to perform construction. (5) Buying...

  17. 24 CFR 401.101 - Which owners are ineligible to request Restructuring Plans?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Housing and Urban Development (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE...

  18. 24 CFR 401.101 - Which owners are ineligible to request Restructuring Plans?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Housing and Urban Development (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE...

  19. 24 CFR 401.101 - Which owners are ineligible to request Restructuring Plans?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Housing and Urban Development (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE...

  20. Do residents in a northern program have better quality lives than their counterparts in a city?

    PubMed Central

    Johnsen, J. H.

    2001-01-01

    OBJECTIVE: To determine whether McMaster University's family medicine residents training in the Family Medicine North (FMN) program have better quality lives than those based in Hamilton, Ont (urban). DESIGN: Residents at both sites were simultaneously given the Quality of Life Questionnaire, a standardized measurement tool. They were asked to complete the questionnaire anonymously and to provide demographic data. SETTING: Family practice residencies in Ontario. PARTICIPANTS: McMaster University's family medicine residents. Of 66 residents living in Hamilton, 36 completed the questionnaire; five respondents were ineligible. Of 25 residents living in Thunder Bay, Ont, 24 completed the questionnaire; none were ineligible. MAIN OUTCOME MEASURES: Total quality-of-life score. Score was divided into five major domains, each with several subdomains: general well-being (material, physical, and personal growth), interpersonal relations (marital, parent-child, extended family, and extramarital), organizational activity (altruistic and political behaviour), occupational activity (job characteristics, occupational relations, and job satisfiers), and leisure and recreational activity (creative/esthetic behaviour, sports activity, vacation behaviour). RESULTS: The FMN residents scored significantly higher than the Hamilton-based residents on overall quality of life (124.7 vs 112.5, P < .05) and tended to score higher in the five major domains. The trend reached statistical significance in general well-being and occupational activity; it was also apparent in various subdomains, with statistically significant differences in material well-being, marital relations, job characteristics, job satisfiers, and vacation behaviour. CONCLUSION: Family Medicine North residents enjoy better quality of life than their urban counterparts based on responses to a standardized questionnaire. PMID:11398733

  1. 7 CFR 766.104 - Borrower eligibility requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... weather, disease, or insect damage which caused severe loss of agricultural production; (iii) Widespread... servicing must pay a portion of the interest due on the loans. (6) The borrower must not be ineligible due...

  2. 7 CFR 766.104 - Borrower eligibility requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... weather, disease, or insect damage which caused severe loss of agricultural production; (iii) Widespread... servicing must pay a portion of the interest due on the loans. (6) The borrower must not be ineligible due...

  3. 7 CFR 766.104 - Borrower eligibility requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... weather, disease, or insect damage which caused severe loss of agricultural production; (iii) Widespread... servicing must pay a portion of the interest due on the loans. (6) The borrower must not be ineligible due...

  4. 7 CFR 766.104 - Borrower eligibility requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... weather, disease, or insect damage which caused severe loss of agricultural production; (iii) Widespread... servicing must pay a portion of the interest due on the loans. (6) The borrower must not be ineligible due...

  5. 29 CFR 6.21 - Ineligible list.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Service Contract Act (and Under the Contract Work Hours and Safety Standards Act for Contracts Subject to... name of any respondent found to be in aggravated or willful violation of the Contract Work Hours and...

  6. 29 CFR 6.21 - Ineligible list.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Service Contract Act (and Under the Contract Work Hours and Safety Standards Act for Contracts Subject to... name of any respondent found to be in aggravated or willful violation of the Contract Work Hours and...

  7. 7 CFR 4280.27 - Ineligible purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Directors, employees, their spouses, children, or close relatives, have a financial or ownership interest in... Resources Act (16 U.S.C. 3501-3510); (l) For any illegal activity or any activity involving prostitution; (m...

  8. 14 CFR 151.75 - Preparation of site.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... on traffic volume or wind conditions (as outlined in § 151.77) and the overall site preparation... preparation cost is prorated based on eligible and ineligible building space. Appendix B of this part sets...

  9. 14 CFR 151.75 - Preparation of site.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... on traffic volume or wind conditions (as outlined in § 151.77) and the overall site preparation... preparation cost is prorated based on eligible and ineligible building space. Appendix B of this part sets...

  10. 14 CFR 151.75 - Preparation of site.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... on traffic volume or wind conditions (as outlined in § 151.77) and the overall site preparation... preparation cost is prorated based on eligible and ineligible building space. Appendix B of this part sets...

  11. 14 CFR 151.75 - Preparation of site.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... on traffic volume or wind conditions (as outlined in § 151.77) and the overall site preparation... preparation cost is prorated based on eligible and ineligible building space. Appendix B of this part sets...

  12. 5 CFR 890.1102 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... (2) A divorce or annulment. (3) A change in circumstances that causes an individual to become ineligible to be considered a child who is a covered family member under this part. [54 FR 52339, Dec. 21...

  13. 29 CFR 452.106 - Preservation of records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... unmarked, must be preserved. Independent certification as to the number and kind of ballots destroyed may... they were received late or because they were cast for an ineligible candidate, must also be preserved...

  14. 7 CFR 4274.319 - Ineligible loan purposes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., race tracks, or gambling facilities. (m) For any line of credit. (n) For any legitimate business activity when more than 10 percent of the annual gross revenue is derived from legalized gambling activity...

  15. 7 CFR 4274.319 - Ineligible loan purposes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., race tracks, or gambling facilities. (m) For any line of credit. (n) For any legitimate business activity when more than 10 percent of the annual gross revenue is derived from legalized gambling activity...

  16. 7 CFR 4274.319 - Ineligible loan purposes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., race tracks, or gambling facilities. (m) For any line of credit. (n) For any legitimate business activity when more than 10 percent of the annual gross revenue is derived from legalized gambling activity...

  17. 7 CFR 3565.206 - Ineligible uses of loan proceeds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... transient residents; (d) Nursing homes, special care facilities and institutional type homes that require licensing as a medical care facility; (e) Operating capital for central dining facilities or for any items...

  18. 7 CFR 3565.206 - Ineligible uses of loan proceeds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... transient residents; (d) Nursing homes, special care facilities and institutional type homes that require licensing as a medical care facility; (e) Operating capital for central dining facilities or for any items...

  19. 7 CFR 3565.206 - Ineligible uses of loan proceeds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... transient residents; (d) Nursing homes, special care facilities and institutional type homes that require licensing as a medical care facility; (e) Operating capital for central dining facilities or for any items...

  20. 7 CFR 3565.206 - Ineligible uses of loan proceeds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... transient residents; (d) Nursing homes, special care facilities and institutional type homes that require licensing as a medical care facility; (e) Operating capital for central dining facilities or for any items...

  1. 7 CFR 3565.206 - Ineligible uses of loan proceeds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... transient residents; (d) Nursing homes, special care facilities and institutional type homes that require licensing as a medical care facility; (e) Operating capital for central dining facilities or for any items...

  2. 39 CFR 601.113 - Debarment, suspension, and ineligibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... business integrity or business honesty. (vi) Any other cause of a serious and compelling nature that... other offense indicating a lack of business integrity or business honesty; (2) For any other cause of...

  3. 39 CFR 601.113 - Debarment, suspension, and ineligibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... business integrity or business honesty. (vi) Any other cause of a serious and compelling nature that... other offense indicating a lack of business integrity or business honesty; (2) For any other cause of...

  4. Combining Angiogenesis-Targeted Treatments for Liver Cancer

    Cancer.gov

    In this trial, patients with unresectable hepatocellular carcinoma who are ineligible for a liver transplant or other local therapies will be given oral sorafenib at the standard approved dose and intravenous TRC105.

  5. 75 FR 59681 - Trade Adjustment Assistance for Farmers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... Service (FAS) has denied a petition (No. 2011029) for trade adjustment assistance for lamb filed under the..., the Administrator was not able to certify the petition, making lamb producers in Montana ineligible...

  6. 7 CFR 1739.13 - Ineligible grant purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Grant funds may not be used to finance the duplication of any existing Broadband Transmission Service provided by another entity. (b) Facilities financed with grant funds cannot be utilized, in any way, to...

  7. Nationwide survey on the use of eltrombopag in patients with severe aplastic anemia: a report on behalf of the French Reference Center for Aplastic Anemia.

    PubMed

    Lengline, Etienne; Drenou, Bernard; Peterlin, Pierre; Tournilhac, Olivier; Abraham, Julie; Berceanu, Ana; Dupriez, Brigitte; Guillerm, Gaelle; Raffoux, Emmanuel; de Fontbrune, Flore Sicre; Ades, Lionel; Balsat, Marie; Chaoui, Driss; Coppo, Paul; Corm, Selim; Leblanc, Thierry; Maillard, Natacha; Terriou, Louis; Socié, Gerard; de Latour, Regis Peffault

    2018-02-01

    Few therapeutic options are available for patients with aplastic anemia who are ineligible for transplantation or refractory to immunosuppressive therapy. Eltrombopag was recently shown to produce trilineage responses in refractory patients. However, the effects of real-life use of this drug remain unknown. This retrospective study (2012-2016) was conducted by the French Reference Center for Aplastic Anemia on patients with relapsed/refractory aplastic anemia, and patients ineligible for antithymocyte globulin or transplantation, who received eltrombopag for at least 2 months. Forty-six patients with aplastic anemia were given eltrombopag without prior antithymocyte globulin treatment (n=11) or after antithymocyte globulin administration (n=35) in a relapsed/refractory setting. Eltrombopag (median daily dose 150 mg) was introduced 17 months (range, 8-50) after the diagnosis of aplastic anemia. At last followup, 49% were still receiving treatment, 9% had stopped due to a robust response, 2% due to toxicity and 40% due to eltrombopag failure. Before eltrombopag treatment, all patients received regular transfusions. The overall rates of red blood cell and platelet transfusion independence were 7%, 33%, 46% and 46% at 1, 3, 6 months and last follow-up. Responses were slower to develop in antithymocyte treatment-naïve patients. In patients achieving transfusion independence, hemoglobin concentration and platelet counts improved by 3 g/dL (interquartile range, 1.4-4.5) and 42×10 9 /L (interquartile range, 11-100), respectively. Response in at least one lineage (according to National Institutes of Health criteria) was observed in 64% of antithymocyte treatment-naïve and 74% of relapsed/refractory patients, while trilineage improvement was observed in 27% and 34%, respectively. We found high rates of hematologic improvement and transfusion independence in refractory aplastic anemia patients but also in patients ineligible for antithymocyte globulin receiving first-line treatment. In conclusion, elderly patients unfit for antithymocyte globulin therapy may benefit from eltrombopag. Copyright© 2018 Ferrata Storti Foundation.

  8. Dyadic Recruitment in Complementary Therapy Studies: Experience from a Clinical Trial of Caregiver-Delivered Reflexology

    PubMed Central

    Holmstrom, Amanda J.; Wyatt, Gwen K.; Sikorskii, Alla; Musatics, Catherine; Stolz, Emily; Havener, Neala

    2015-01-01

    Purpose As home-based care continues to be a growing trend in health care, involvement of friend and family caregivers in the management of illness becomes essential. However, before nurses can prepare caregivers to engage in various types of care, an evidence base needs to be established via randomized controlled trials (RCTs). Research suggests that recruiting cancer patients and their friend or family caregivers into RCTs presents challenges. The purpose of this paper is to illustrate the barriers to recruitment of patient-caregiver dyads into a RCT of caregiver-delivered reflexology and to recommend strategies to address such barriers. Methods This paper reports on a nurse-directed RCT that involved recruitment efforts unique to a caregiver-delivered reflexology protocol for advanced-stage breast cancer patients. Ineligibility due to caregiver-related reasons, consent among eligible patients (out of 551 approached patients), and reasons for refusal were analyzed. Results Almost one-third of patients were found to be ineligible due to the lack of a caregiver to participate with them and provide this form of social support. Among eligible patients, the consent rate for this dyadic study is much lower than that of previous RCTs of reflexologist-delivered reflexology that enrolled just patients, not dyads. Conclusion Implications for nursing practice and research include addressing the need for greater social support for patients and strategies for problem-solving refusal reasons during study enrollment. PMID:26856504

  9. Atezolizumab as first-line therapy in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial

    PubMed Central

    Balar, Arjun V; Galsky, Matthew D; Rosenberg, Jonathan E; Powles, Thomas; Petrylak, Daniel P; Bellmunt, Joaquim; Loriot, Yohann; Necchi, Andrea; Hoffman-Censits, Jean; Perez-Gracia, Jose Luis; Dawson, Nancy A; van der Heijden, Michiel S; Dreicer, Robert; Srinivas, Sandy; Retz, Margitta M; Joseph, Richard W; Drakaki, Alexandra; Vaishampayan, Ulka N; Sridhar, Srikala S; Quinn, David I; Durán, Ignacio; Shaffer, David R; Eigl, Bernhard J; Grivas, Petros D; Yu, Evan Y; Li, Shi; Kadel, Edward E; Boyd, Zachary; Bourgon, Richard; Hegde, Priti S; Mariathasan, Sanjeev; Thåström, AnnChristine; Abidoye, Oyewale O; Fine, Gregg D; Bajorin, Dean F

    2017-01-01

    Summary Background First-line chemotherapy for patients with cisplatin-ineligible locally-advanced or metastatic urothelial carcinoma (mUC) is associated with short response duration, poor survival, and high toxicity. This multicenter, 2-cohort phase 2 study evaluated atezolizumab (anti–programmed death-ligand 1 [PD-L1]) as treatment for mUC in this setting, as well as in later lines. Methods In a cohort of previously untreated patients who were cisplatin ineligible, atezolizumab was given 1200 mg every 3 weeks until progression. The primary endpoint was independently confirmed objective response rate per Response Evaluation Criteria In Solid Tumors v1.1 (central review), evaluated in pre-specified subgroups based on PD-L1 expression and in all patients. Secondary endpoints included response duration, progression-free survival, overall survival, and safety. Exploratory analyses included biomarker correlates of response and survival. This study is registered with ClinicalTrials.gov, number NCT02108652. Findings Of 119 patients who received atezolizumab in the first-line setting, 83 (70%) had baseline renal impairment, and 24 (20%) had Eastern Cooperative Oncology Group performance status 2. At 17·2 months’ median follow-up, the objective response rate was 23% (95% CI 16–31), the complete response rate was 9%, and 19 of 27 responses were ongoing. Median response duration was not reached. Responses occurred across all PD-L1 and poor prognostic factor subgroups. Median progression-free survival was 2·7 months. Median overall survival was 15·9 months. Tumour mutation load was associated with response. Treatment-related adverse events ≥10% were fatigue, diarrhoea, and pruritus. One treatment-related death (sepsis) occurred. Nine patients (8%) had an adverse event leading to treatment discontinuation. Immune-mediated events occurred in 14 (12%) patients. Interpretation Atezolizumab demonstrated encouraging durable response rates, survival, and tolerability, supporting its therapeutic use in untreated mUC. Funding F. Hoffmann-La Roche Ltd./Genentech, Inc., a member of the Roche Group. PMID:27939400

  10. Is the use of IL28B genotype justified in the era of interferon-free treatments for hepatitis C?

    PubMed Central

    Kanda, Tatsuo; Nakamoto, Shingo; Yokosuka, Osamu

    2015-01-01

    In 2009, several groups reported that interleukin-28B (IL28B) genotypes are associated with the response to peginterferon plus ribavirin therapy for chronic hepatitis C virus (HCV) infection in a genome-wide association study, although the mechanism of this association is not yet well understood. However, in recent years, tremendous progress has been made in the treatment of HCV infection. In Japan, some patients infected with HCV have the IL28B major genotype, which may indicate a favorable response to interferon-including regimens; however, certain patients within this group are also interferon-intolerant or ineligible. In Japan, interferon-free 24-wk regimens of asunaprevir and daclatasvir are now available for HCV genotype 1b-infected patients who are interferon-intolerant or ineligible or previous treatment null-responders. The treatment response to interferon-free regimens appears better, regardless of IL28B genotype. Maybe other interferon-free regimens will widely be available soon. In conclusion, although some HCV-infected individuals have IL28B favorable alleles, importance of IL28B will be reduced with availability of oral interferon free regimen. PMID:26279979

  11. 47 CFR 95.5 - Licensee eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES General Mobile Radio Service (GMRS) § 95.5 Licensee eligibility. (a) An individual (one man or one... entity other than an individual) is ineligible to obtain a new GMRS system license or make a major...

  12. 7 CFR 1484.51 - What are ineligible contributions?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... personnel provided by any U.S. government agency; (10) Capital investments made by a third party, such as... party, e.g., free publicity; (12) Membership fees in clubs and social organizations; and (13) costs...

  13. 30 CFR 773.12 - Permit eligibility determination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and your control was established or the violation was cited after November 2, 1988. (b) We will not... you are ineligible and include notice of your appeal rights under part 775 of this subchapter and 43...

  14. 50 CFR 92.10 - Alaska Migratory Bird Co-management Council.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... criteria by which areas and communities can be determined to be eligible or ineligible for a spring/summer... arrangements for the meeting rooms and associated logistics related to Co-management Council meetings; (2...

  15. 50 CFR 92.10 - Alaska Migratory Bird Co-management Council.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... criteria by which areas and communities can be determined to be eligible or ineligible for a spring/summer... arrangements for the meeting rooms and associated logistics related to Co-management Council meetings; (2...

  16. 50 CFR 92.10 - Alaska Migratory Bird Co-management Council.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... criteria by which areas and communities can be determined to be eligible or ineligible for a spring/summer... arrangements for the meeting rooms and associated logistics related to Co-management Council meetings; (2...

  17. 50 CFR 92.10 - Alaska Migratory Bird Co-management Council.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... criteria by which areas and communities can be determined to be eligible or ineligible for a spring/summer... arrangements for the meeting rooms and associated logistics related to Co-management Council meetings; (2...

  18. 50 CFR 92.10 - Alaska Migratory Bird Co-management Council.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... criteria by which areas and communities can be determined to be eligible or ineligible for a spring/summer... arrangements for the meeting rooms and associated logistics related to Co-management Council meetings; (2...

  19. 7 CFR 2201.15 - Ineligible Loan purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... extends, upgrades, or enhances the services provided over any cable system to an area that, as of the enactment of the Act, is covered by a cable franchise agreement that expressly obligates a cable operator to...

  20. 7 CFR 1486.402 - What are ineligible contributions?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Recipient or third party, e.g., free publicity; (10) The cost of developing any application/proposal for EMP... approval of an EMP-funded project. (b) The Deputy Administrator shall determine, at his or her discretion...

  1. 24 CFR 761.17 - Eligible and ineligible activities for funding.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... provided in 42 U.S.C. 11903(a)(6). (7) Funding resident management corporations (RMCs), resident councils...). (8) Youth sports. Sports programs and sports activities that serve primarily youths from public or...

  2. 24 CFR 761.17 - Eligible and ineligible activities for funding.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... provided in 42 U.S.C. 11903(a)(6). (7) Funding resident management corporations (RMCs), resident councils...). (8) Youth sports. Sports programs and sports activities that serve primarily youths from public or...

  3. 7 CFR 1484.51 - What are ineligible contributions?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... personnel provided by any U.S. government agency; (10) Capital investments made by a third party, such as... party, e.g., free publicity; (12) Membership fees in clubs and social organizations; and (13) costs...

  4. 38 CFR 39.84 - Application requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., the State or Tribal Organization must submit an application (as opposed to a preapplication... Debarment, Suspension, Ineligibility and Voluntary Exclusion-Lower Tier Covered Transactions (Contractor... Management and Budget has approved the information collection requirements in this section under control...

  5. 38 CFR 39.84 - Application requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., the State or Tribal Organization must submit an application (as opposed to a preapplication... Debarment, Suspension, Ineligibility and Voluntary Exclusion-Lower Tier Covered Transactions (Contractor... Management and Budget has approved the information collection requirements in this section under control...

  6. 48 CFR 2809.402 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 2809.402 Section 2809.402 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Competition and Acquisition Planning CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 2809.402 Policy. Contracting...

  7. 48 CFR 2809.402 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Policy. 2809.402 Section 2809.402 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 2809.402 Policy. Contracting...

  8. 48 CFR 2809.402 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Policy. 2809.402 Section 2809.402 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 2809.402 Policy. Contracting...

  9. 5 CFR 575.104 - Ineligible categories of employees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....S.C. 3132(a)(5) and (a)(6), respectively) when the appointment must be cleared through the White House Office of Presidential Personnel. [70 FR 25740, May 13, 2005, as amended at 78 FR 49363, Aug. 14...

  10. 5 CFR 575.304 - Ineligible categories of employees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....S.C. 3132(a)(5) and (a)(6), respectively) when the appointment must be cleared through the White House Office of Presidential Personnel. [70 FR 25747, May 13, 2005, as amended at 78 FR 49364, Aug. 14...

  11. 5 CFR 575.204 - Ineligible categories of employees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....S.C. 3132(a)(5) and (a)(6), respectively) when the appointment must be cleared through the White House Office of Presidential Personnel. [70 FR 25743, May 13, 2005, as amended at 78 FR 49363, Aug. 14...

  12. 29 CFR 452.38 - Meeting attendance requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., where over 97 percent of the members were ineligible (Wirtz v. Local 153, Glass Bottle Blowers Ass'n... Blowers Ass'n., 290 F. Supp. 965 (N.D. Cal., 1968)); attendance at each of eight meetings in the two...

  13. 29 CFR 452.38 - Meeting attendance requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., where over 97 percent of the members were ineligible (Wirtz v. Local 153, Glass Bottle Blowers Ass'n... Blowers Ass'n., 290 F. Supp. 965 (N.D. Cal., 1968)); attendance at each of eight meetings in the two...

  14. 29 CFR 452.38 - Meeting attendance requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., where over 97 percent of the members were ineligible (Wirtz v. Local 153, Glass Bottle Blowers Ass'n... Blowers Ass'n., 290 F. Supp. 965 (N.D. Cal., 1968)); attendance at each of eight meetings in the two...

  15. 29 CFR 452.38 - Meeting attendance requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., where over 97 percent of the members were ineligible (Wirtz v. Local 153, Glass Bottle Blowers Ass'n... Blowers Ass'n., 290 F. Supp. 965 (N.D. Cal., 1968)); attendance at each of eight meetings in the two...

  16. 48 CFR 2509.403 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Definitions. 2509.403 Section 2509.403 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 2509.403 Definitions. The NSF Deputy...

  17. 48 CFR 1609.471 - Contractor certification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor certification... EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 1609.471 Contractor certification. All FEHBP carriers and applicant carriers...

  18. 48 CFR 3409.406 - Debarment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Debarment. 3409.406 Section 3409.406 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 3409...

  19. 48 CFR 3409.403 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false [Reserved] 3409.403 Section 3409.403 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 3409...

  20. The impact of visa status and Medicare eligibility on people diagnosed with HIV in Western Australia: a qualitative report.

    PubMed

    Herrmann, Susan; Wardrop, Joan; John, Mina; Gaudieri, Silvana; Lucas, Michaela; Mallal, Simon; Nolan, David

    2012-11-01

    In Australia, temporary visa holders are ineligible for Medicare and subsidised antiretroviral drugs. Additionally, HIV testing is not mandatory for visas unless applicants seek work in the health sector. We sought to understand the impact of HIV and issues of access and adherence to antiretroviral therapy (ART) in people holding temporary visas and permanent residents. Data were gathered from interviews with 22 participants. Information concerning medication adherence, side effects, CD4 T-cell count, viral load and rate of response to generic drugs were collected. The mean age was 33.4 years (±s.d.=6.0), 21 out of 22 were from HIV-prevalent areas in East Africa and Asia, 14 out of 22 were on temporary visas, 12 were ineligible for Medicare, 14 out of 22 were diagnosed during health screening, 19 out of 22 risk exposures were in country of origin, 8 out of 17 were taking generic ART at an average cost of $180 per month, adherence was excellent and self-reported side-effects were relatively infrequent. Participants applying for visa continuations and permanent residency were fearful, believing their HIV serostatus would prejudice their applications. Patients cited belief in ART efficacy, were motivated to maintain therapy and were anxious about lack of access to treatment in their countries of origin. Adherence to antiretroviral drugs in Medicare-ineligible HIV-infected individuals is excellent despite limited access to treatment. The threat of visa non-renewal and the likely failure of applications for permanent residency result in considerable anxiety and confidentiality concerns.

  1. 46 CFR 531.2 - Scope and applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 515 may enter into an NSA with one or more NSA shippers subject to the requirements of these rules... the Commission is ineligible to offer and file NSAs. [69 FR 75853, Dec. 20, 2004, as amended at 74 FR...

  2. 46 CFR 531.2 - Scope and applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 515 may enter into an NSA with one or more NSA shippers subject to the requirements of these rules... the Commission is ineligible to offer and file NSAs. [69 FR 75853, Dec. 20, 2004, as amended at 74 FR...

  3. 46 CFR 531.2 - Scope and applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 515 may enter into an NSA with one or more NSA shippers subject to the requirements of these rules... the Commission is ineligible to offer and file NSAs. [69 FR 75853, Dec. 20, 2004, as amended at 74 FR...

  4. 46 CFR 531.2 - Scope and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 515 may enter into an NSA with one or more NSA shippers subject to the requirements of these rules... the Commission is ineligible to offer and file NSAs. [69 FR 75853, Dec. 20, 2004, as amended at 74 FR...

  5. 46 CFR 531.2 - Scope and applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 515 may enter into an NSA with one or more NSA shippers subject to the requirements of these rules... the Commission is ineligible to offer and file NSAs. [69 FR 75853, Dec. 20, 2004, as amended at 74 FR...

  6. 29 CFR 4.188 - Ineligibility for further contracts when violations occur.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...” will be deemed to exist. Similarly, where a person is an officer or director in a firm or the debarred...-sharing, or other basis of remuneration, including indirect compensation by virtue of family relationships...

  7. RMP Guidance for Chemical Distributors - Chapter 6: Prevention Program (Program 2)

    EPA Pesticide Factsheets

    If your processes are ineligible for Program 1 and you have substances above the threshold that are not covered by OSHA’s Process Safety Management standard, you have Program 2 processes and Prevention Program applies.

  8. Report: Utah Department of Environmental Quality Water Quality State Revolving Fund Fiscal Year 2004 Financial Statements

    EPA Pesticide Factsheets

    Report #2005-1-00144, August 8, 2005. We noted weaknesses in internal controls. DEQ internal controls failed to prevent the SRF disbursement, recording and reporting of $479,961 in ineligible assistance.

  9. 42 CFR 63.9 - How may NIH terminate awards?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... committed misconduct in science, is ineligible, or has materially failed to comply with the terms and conditions of the award or to carry out the purpose for which the award was made; or (c) If the awardee is...

  10. 32 CFR 553.17 - Persons ineligible for burial in an Army national cemetery.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... burial in an Army national cemetery. (a) A father, mother, brother, sister, and in-law is not eligible... for burial in Arlington National Cemetery unless the Service-connected family member has been or will...

  11. 48 CFR 3409.406-3 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Procedures. 3409.406-3 Section 3409.406-3 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 3409...

  12. 14 CFR Appendix D to Part 151 - Appendix D to Part 151

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...: Typical Eligible Items 1. Basic types of pavement listed as eligible under § 151.77. 2. Taxiway providing... storage hangars and/or multiple-unit tee hangars. Typical Ineligible Items 1. Basic types of pavement...

  13. The Archaeology and History of Lake Ray Roberts. Volume 1. Cultural Resources Survey.

    DTIC Science & Technology

    1982-03-01

    the survey have rendered the information they contain through the recording process and should be determined ineligible for further study. Fifty-five...clay features were actually human hearths ( Heizer and Brooks 1965), and the possibility that the Clovis point was planted ( Heizer 1974). Recent research...15:157-172. Hart, John Fraser 1976 The look of the land. Prentice-Hall, Englewood Cliffs, New Jersey. * 9-5 Heizer , R.F. 1974 Some thoughts on hoaxes

  14. The accuracy of using last menstrual period to determine gestational age for first trimester medication abortion: a systematic review.

    PubMed

    Schonberg, Dana; Wang, Lin-Fan; Bennett, Ariana H; Gold, Marji; Jackson, Emily

    2014-11-01

    We sought to evaluate the accuracy of assessing gestational age (GA) prior to first trimester medication abortion using last menstrual period (LMP) compared to ultrasound (U/S). We searched Medline, Embase and Cochrane databases through October 2013 for peer-reviewed articles comparing LMP to U/S for GA dating in abortion care. Two teams of investigators independently evaluated data using standard abstraction forms. The US Preventive Services Task Force and Quality Assessment of Diagnostic Accuracy Studies guidelines were used to assess quality. Of 318 articles identified, 5 met inclusion criteria. Three studies reported that 2.5-11.8% of women were eligible for medication abortion by LMP and ineligible by U/S. The number of women who underestimated GA using LMP compared to U/S ranged from 1.8 to 14.8%, with lower rates found when the sample was limited to a GA <63 days. Most women (90.5-99.1%) knew their LMP, 70.8-90.5% with certainty. Our results support that LMP can be used to assess GA prior to medication abortion at GA <63 days. Further research looking at patient outcomes and identifying women eligible for medication abortion by LMP but ineligible by U/S is needed to confirm the safety and effectiveness of providing medication abortion using LMP alone to determine GA. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Dyadic recruitment in complementary therapy studies: experience from a clinical trial of caregiver-delivered reflexology.

    PubMed

    Holmstrom, Amanda J; Wyatt, Gwen K; Sikorskii, Alla; Musatics, Catherine; Stolz, Emily; Havener, Neala

    2016-02-01

    As home-based care continues to be a growing trend in health care, involvement of friend and family caregivers in the management of illness becomes essential. However, before nurses can prepare caregivers to engage in various types of care, an evidence base needs to be established via randomized controlled trials (RCTs). Research suggests that recruiting cancer patients and their friend or family caregivers into RCTs presents challenges. The purpose of this paper is to illustrate the barriers to recruitment of patient-caregiver dyads into a RCT of caregiver-delivered reflexology and to recommend strategies to address such barriers. This paper reports on a nurse-directed RCT that involved recruitment efforts unique to a caregiver-delivered reflexology protocol for advanced-stage breast cancer patients. Ineligibility due to caregiver-related reasons, consent among eligible patients (out of 551 approached patients), and reasons for refusal were analyzed. Almost one-third of patients were found to be ineligible due to the lack of a caregiver to participate with them and provide this form of social support. Among eligible patients, the consent rate for this dyadic study is much lower than that of previous RCTs of reflexologist-delivered reflexology that enrolled just patients, not dyads. Implications for nursing practice and research include addressing the need for greater social support for patients and strategies for problem-solving refusal reasons during study enrollment. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. 48 CFR 9.402 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 9.402 Policy. (a) Agencies shall solicit... means to effectuate this policy. (b) The serious nature of debarment and suspension requires that these... punishment. Agencies shall impose debarment or suspension to protect the Government's interest and only for...

  17. 12 CFR 263.94 - Conduct warranting sanctions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... an attorney, or debarment or suspension from practice as a certified public accountant or public... that individual's period of suspension, debarment, or ineligibility; (f) Contemptuous conduct in... circulating or publishing malicious or libelous matter; (g) Suspension or debarment from practice before the...

  18. 7 CFR 4288.134 - Refunds and interest payments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program General Provisions § 4288.134 Refunds and interest payments. An eligible advanced biofuel producer...) An eligible advanced biofuel producer receiving payments under this subpart shall become ineligible...

  19. 7 CFR 4288.134 - Refunds and interest payments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program General Provisions § 4288.134 Refunds and interest payments. An eligible advanced biofuel producer...) An eligible advanced biofuel producer receiving payments under this subpart shall become ineligible...

  20. 48 CFR 1409.403 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Definitions. 1409.403... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 1409.403 Definitions... matters. The Office of Inspector General (OIG) may also refer actions. Conviction, for the purposes of...

  1. 48 CFR 1409.403 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Definitions. 1409.403... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 1409.403 Definitions... matters. The Office of Inspector General (OIG) may also refer actions. Conviction, for the purposes of...

  2. 24 CFR 578.53 - Supportive services.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... violence, dating violence, sexual assault, or stalking. (d) Ineligible costs. Any cost that is not... participant(s) are eligible costs. Component services and activities consist of: (i) Counseling; (ii..., dating violence, sexual assault, and stalking; and (viii) Developing an individualized housing and...

  3. 24 CFR 578.53 - Supportive services.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... violence, dating violence, sexual assault, or stalking. (d) Ineligible costs. Any cost that is not... participant(s) are eligible costs. Component services and activities consist of: (i) Counseling; (ii..., dating violence, sexual assault, and stalking; and (viii) Developing an individualized housing and...

  4. 48 CFR 2009.405 - Effect of listing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Effect of listing. 2009.405 Section 2009.405 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 2009.405 Effect of...

  5. 48 CFR 2509.405 - Effect of listing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Effect of listing. 2509.405 Section 2509.405 Federal Acquisition Regulations System NATIONAL SCIENCE FOUNDATION ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 2509.405 Effect of listing. ...

  6. 50 CFR 80.11 - How does a State become ineligible to receive the benefits of the Acts?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE AND SPORT FISH... SPORT FISH RESTORATION ACTS State Fish and Wildlife Agency Eligibility § 80.11 How does a State become...

  7. 50 CFR 80.11 - How does a State become ineligible to receive the benefits of the Acts?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE AND SPORT FISH... SPORT FISH RESTORATION ACTS State Fish and Wildlife Agency Eligibility § 80.11 How does a State become...

  8. 77 FR 43773 - Wireline Competition Bureau Seeks Further Comment on Issues in the Rural Health Care Reform...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... and Primary programs in supporting any recommendations for streamlined application procedures. b. Post... ineligible HCPs) by taking into account a variety of healthcare-specific factors. We note that in the Pilot...

  9. 7 CFR 1980.412 - Ineligible loan purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., feeding (including commercial custom feedlots), breeding, hatching, control, and/or management of farm and.... (2) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other... capacity of existing competitive commercial or industrial enterprises, unless such financial or other...

  10. 7 CFR 1980.412 - Ineligible loan purposes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., feeding (including commercial custom feedlots), breeding, hatching, control, and/or management of farm and.... (2) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other... capacity of existing competitive commercial or industrial enterprises, unless such financial or other...

  11. 7 CFR 1980.412 - Ineligible loan purposes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., feeding (including commercial custom feedlots), breeding, hatching, control, and/or management of farm and.... (2) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other... capacity of existing competitive commercial or industrial enterprises, unless such financial or other...

  12. 7 CFR 1980.412 - Ineligible loan purposes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., feeding (including commercial custom feedlots), breeding, hatching, control, and/or management of farm and.... (2) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other... capacity of existing competitive commercial or industrial enterprises, unless such financial or other...

  13. 7 CFR 1980.412 - Ineligible loan purposes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., feeding (including commercial custom feedlots), breeding, hatching, control, and/or management of farm and.... (2) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other... capacity of existing competitive commercial or industrial enterprises, unless such financial or other...

  14. 50 CFR 84.20 - What are the grant eligibility requirements?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM NATIONAL COASTAL... restoration, enhancement, or management of coastal wetlands ecosystems, providing restoration, enhancement, or management will be administered for long-term conservation. (b) Ineligible activities include but are not...

  15. 50 CFR 84.20 - What are the grant eligibility requirements?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE AND SPORT FISH RESTORATION PROGRAM NATIONAL... restoration, enhancement, or management of coastal wetlands ecosystems, providing restoration, enhancement, or management will be administered for long-term conservation. (b) Ineligible activities include but are not...

  16. 50 CFR 84.20 - What are the grant eligibility requirements?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE AND SPORT FISH RESTORATION PROGRAM NATIONAL... restoration, enhancement, or management of coastal wetlands ecosystems, providing restoration, enhancement, or management will be administered for long-term conservation. (b) Ineligible activities include but are not...

  17. 22 CFR 208.145 - Does this part address persons who are disqualified, as well as those who are excluded from...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION... ineligible. Those transactions vary on a case-by-case basis, because they depend on the language of the...

  18. 22 CFR 1508.145 - Does this part address persons who are disqualified, as well as those who are excluded from...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT... ineligible. Those transactions vary on a case-by-case basis, because they depend on the language of the...

  19. 48 CFR 2909.405 - Effect of listing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Effect of listing. 2909.405 Section 2909.405 Federal Acquisition Regulations System DEPARTMENT OF LABOR ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 2909.405 Effect of listing. (a...

  20. 14 CFR Appendix E to Part 151 - Appendix E to Part 151

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...: Typical Eligible Items 1. Basic types of pavement listed as eligible under § 151.77. 2. Loading ramps. 3... of pavement listed as ineligible under § 151.77. 2. Aprons serving installations for nonpublic use. 3...

  1. 8 CFR 245a.18 - Ineligibility and applicability of grounds of inadmissibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... section: (i) Section 212(a)(2)(A)(i)(I) (crimes involving moral turpitude); (ii) Section 212(a)(2)(A)(i... simple possession of 30 grams or less of marijuana); (iii) Section 212(a)(2)(B) (multiple criminal...

  2. 8 CFR 245a.18 - Ineligibility and applicability of grounds of inadmissibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section: (i) Section 212(a)(2)(A)(i)(I) (crimes involving moral turpitude); (ii) Section 212(a)(2)(A)(i... simple possession of 30 grams or less of marijuana); (iii) Section 212(a)(2)(B) (multiple criminal...

  3. Cardiometabolic Mortality by Supplemental Nutrition Assistance Program Participation and Eligibility in the United States

    PubMed Central

    Rehm, Colin D.; Wilde, Parke; Mozaffarian, Dariush

    2017-01-01

    Objectives. To investigate total and cause-specific cardiometabolic mortality among Supplemental Nutrition Assistance Program (SNAP) participants, SNAP-eligible nonparticipants, and SNAP-ineligible individuals overall and by age, gender, race/ethnicity, and other characteristics. Methods. We performed a prospective study with nationally representative survey data from the National Health Interview Survey (2000–2009), merged with subsequent Public-Use Linked Mortality Files (2000–2011). We used survey-weighted Cox proportional hazards models adjusted for age and gender to estimate hazard ratios of total and cause-specific cardiometabolic mortality for 499 741 US adults aged 25 years or older. Results. Over a mean of 6.8 years of follow-up (maximum 11.9 years), 39 293 deaths occurred, including 7408 heart disease, 2185 stroke, and 1376 diabetes deaths. Individuals participating in SNAP exhibited higher total and cardiovascular disease mortality, largely limited to non-Hispanic Whites and non-Hispanic Blacks, than both SNAP-eligible nonparticipants and SNAP-ineligible individuals, and higher diabetes mortality across races/ethnicities (P < .01). Conclusions. Participants in SNAP require greater focus to understand and further address their poor health outcomes. Public Health Implications. Low-income Americans require even greater efforts to improve their health than they currently receive, and such efforts should be a priority for public health policymakers. PMID:28103061

  4. How Accurately Do Consecutive Cohort Audits Predict Phase III Multisite Clinical Trial Recruitment in Palliative Care?

    PubMed

    McCaffrey, Nikki; Fazekas, Belinda; Cutri, Natalie; Currow, David C

    2016-04-01

    Audits have been proposed for estimating possible recruitment rates to randomized controlled trials (RCTs), but few studies have compared audit data with subsequent recruitment rates. To compare the accuracy of estimates of potential recruitment from a retrospective consecutive cohort audit of actual participating sites and recruitment to four Phase III multisite clinical RCTs. The proportion of potentially eligible study participants estimated from an inpatient chart review of people with life-limiting illnesses referred to six Australian specialist palliative care services was compared with recruitment data extracted from study prescreening information from three sites that participated fully in four Palliative Care Clinical Studies Collaborative RCTs. The predominant reasons for ineligibility in the audit and RCTs were analyzed. The audit overestimated the proportion of people referred to the palliative care services who could participate in the RCTs (pain 17.7% vs. 1.2%, delirium 5.8% vs. 0.6%, anorexia 5.1% vs. 0.8%, and bowel obstruction 2.8% vs. 0.5%). Approximately 2% of the referral base was potentially eligible for these effectiveness studies. Ineligibility for general criteria (language, cognition, and geographic proximity) varied between studies, whereas the reasons for exclusion were similar between the audit and pain and anorexia studies but not for delirium or bowel obstruction. The retrospective consecutive case note audit in participating sites did not predict realistic recruitment rates, mostly underestimating the impact of study-specific inclusion criteria. These findings have implications for the applicability of the results of RCTs. Prospective pilot studies are more likely to predict actual recruitment. Copyright © 2016 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  5. 44 CFR 152.3 - Availability of funds.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HOMELAND SECURITY FIRE PREVENTION AND CONTROL ASSISTANCE TO FIREFIGHTERS GRANT PROGRAM § 152.3 Availability... can submit more than one application per fiscal year. Applicants that submit multiple applications will have each of their applications deemed ineligible. (d) The scoring of the applications will...

  6. 48 CFR 9.405 - Effect of listing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Effect of listing. 9.405 Section 9.405 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 9.405 Effect of listing. (a) Contractors...

  7. 48 CFR 2809.405 - Effect of listing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Effect of listing. 2809.405 Section 2809.405 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Competition and Acquisition Planning CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 2809.405 Effect of listing. (a...

  8. 42 CFR 68a.5 - Who is ineligible to participate?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) CLINICAL RESEARCH LOAN REPAYMENT PROGRAM FOR...: Physicians Shortage Area Scholarship Program, National Research Service Award Program, Public Health Service...) Professions Scholarship Program, Indian Health Service Scholarship Program, and the NIH AIDS Research Loan...

  9. 7 CFR 4280.111 - Notifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... will be notified of the Agency's decision on their application. Renewable Energy System and Energy... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General... the applicant or the project is ineligible, the Agency will inform the applicant or lender, as...

  10. 7 CFR 4280.111 - Notifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... will be notified of the Agency's decision on their application. Renewable Energy System and Energy... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General... the applicant or the project is ineligible, the Agency will inform the applicant or lender, as...

  11. 7 CFR 4280.111 - Notifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... will be notified of the Agency's decision on their application. Renewable Energy System and Energy... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General... the applicant or the project is ineligible, the Agency will inform the applicant or lender, as...

  12. 7 CFR 1951.854 - Ineligible assistance purposes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... raising, housing, feeding, breeding, hatching, control and/or management of farm and domestic animals). Exceptions to this definition are: (i) Aquaculture as identified under eligible purposes. (ii) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other nursery products such...

  13. 7 CFR 1951.854 - Ineligible assistance purposes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... raising, housing, feeding, breeding, hatching, control and/or management of farm and domestic animals). Exceptions to this definition are: (i) Aquaculture as identified under eligible purposes. (ii) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other nursery products such...

  14. 7 CFR 1951.854 - Ineligible assistance purposes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... raising, housing, feeding, breeding, hatching, control and/or management of farm and domestic animals). Exceptions to this definition are: (i) Aquaculture as identified under eligible purposes. (ii) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other nursery products such...

  15. 7 CFR 1951.854 - Ineligible assistance purposes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... raising, housing, feeding, breeding, hatching, control and/or management of farm and domestic animals). Exceptions to this definition are: (i) Aquaculture as identified under eligible purposes. (ii) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other nursery products such...

  16. 7 CFR 1951.854 - Ineligible assistance purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... raising, housing, feeding, breeding, hatching, control and/or management of farm and domestic animals). Exceptions to this definition are: (i) Aquaculture as identified under eligible purposes. (ii) Commercial nurseries primarily engaged in the production of ornamental plants and trees and other nursery products such...

  17. 24 CFR 882.401 - Eligible properties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Ineligible properties. (1) Nursing homes, units within the grounds of penal, reformatory, medical, mental and similar public or private institutions, and facilities providing continual psychiatric, medical or nursing... State or unit of general local government is not eligible for assistance under this program. (3) High...

  18. 24 CFR 882.401 - Eligible properties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Ineligible properties. (1) Nursing homes, units within the grounds of penal, reformatory, medical, mental and similar public or private institutions, and facilities providing continual psychiatric, medical or nursing... State or unit of general local government is not eligible for assistance under this program. (3) High...

  19. 24 CFR 882.401 - Eligible properties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Ineligible properties. (1) Nursing homes, units within the grounds of penal, reformatory, medical, mental and similar public or private institutions, and facilities providing continual psychiatric, medical or nursing... State or unit of general local government is not eligible for assistance under this program. (3) High...

  20. 24 CFR 882.401 - Eligible properties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Ineligible properties. (1) Nursing homes, units within the grounds of penal, reformatory, medical, mental and similar public or private institutions, and facilities providing continual psychiatric, medical or nursing... State or unit of general local government is not eligible for assistance under this program. (3) High...

  1. 7 CFR 635.4 - Failure to fully comply.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Failure to fully comply. 635.4 Section 635.4..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING EQUITABLE RELIEF FROM INELIGIBILITY § 635.4 Failure to fully... damages or failure that were minor in nature. ...

  2. 7 CFR 635.4 - Failure to fully comply.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Failure to fully comply. 635.4 Section 635.4..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING EQUITABLE RELIEF FROM INELIGIBILITY § 635.4 Failure to fully... damages or failure that were minor in nature. ...

  3. 7 CFR 635.4 - Failure to fully comply.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Failure to fully comply. 635.4 Section 635.4..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING EQUITABLE RELIEF FROM INELIGIBILITY § 635.4 Failure to fully... damages or failure that were minor in nature. ...

  4. 48 CFR 809.405 - Effect of listing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Effect of listing. 809.405 Section 809.405 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 809.405 Effect of...

  5. Factors Associated with Timing of Initiation of Antiretroviral Therapy among HIV-1 Infected Adults in the Niger Delta Region of Nigeria

    PubMed Central

    Ogoina, Dimie

    2015-01-01

    Introduction Based on growing evidence mainly from countries outside Sub-Saharan Africa, the World Health Organisation (WHO) now recommends initiation of antiretroviral therapy (ART) in HIV-infected individuals in developing countries when CD4 cell count (CD4+) is ≤ 500cells/ul. Nigeria accounts for about 14% of the estimated HIV/AIDS burden in Sub-Saharan Africa. We evaluated the factors associated with timing of initiation of ART among treatment-ineligible HIV-infected adults from Nigeria. Methods We retrospectively reviewed the hospital records of ART ineligible HIV-infected adults who enrolled into HIV care between January 2008 and December 2012 at two major tertiary hospitals in Bayelsa State, South-South Nigeria. Demographic, clinical and laboratories data were obtained at presentation, at each subsequent visit at 6 monthly intervals and at time of initiation of ART. Cox proportional regression and Kaplan-Meier survival analysis were used to evaluate independent predictors of time to initiation of ART. Results Amongst the 280 study participants, 70.6% were females, 62.6% had CD4+ ≥500cells/ul, 48.4% had WHO HIV Stage 1 disease and 34.3% were lost to follow up. In a cohort of 180 participants followed up for ≥3months, participants with CD4+ of 351-500cells/ul and stage 2 disease were more likely to start ART earlier than those with CD4+ > 500cells/ul (Hazard ratio [HR]-1.7, 95% confidence interval [CI] of 1.0-2.9) and stage 1 disease (HR-2.3 (95% CI-1.3-4.2) respectively. HIV-infected adults with faster CD4+ decay required earlier ART initiation, especially in the first year of follow up. Conclusion ART-ineligible HIV-infected adults on follow up in South-South Nigeria are more likely to require earlier initiation of ART if they have stage 2 HIV disease or CD4+ ≤500cells/ul at presentation. Our findings suggest faster progression of HIV-disease in these groups of individuals and corroborate the growing evidence in support for earlier initiation of ART. PMID:25933356

  6. Government health insurance for people below poverty line in India: quasi-experimental evaluation of insurance and health outcomes.

    PubMed

    Sood, Neeraj; Bendavid, Eran; Mukherji, Arnab; Wagner, Zachary; Nagpal, Somil; Mullen, Patrick

    2014-09-11

    To evaluate the effects of a government insurance program covering tertiary care for people below the poverty line in Karnataka, India, on out-of-pocket expenditures, hospital use, and mortality. Geographic regression discontinuity study. 572 villages in Karnataka, India. 31,476 households (22,796 below poverty line and 8680 above poverty line) in 300 villages where the scheme was implemented and 28,633 households (21,767 below poverty line and 6866 above poverty line) in 272 neighboring matched villages ineligible for the scheme. A government insurance program (Vajpayee Arogyashree scheme) that provided free tertiary care to households below the poverty line in about half of villages in Karnataka from February 2010 to August 2012. Out-of-pocket expenditures, hospital use, and mortality. Among households below the poverty line, the mortality rate from conditions potentially responsive to services covered by the scheme (mostly cardiac conditions and cancer) was 0.32% in households eligible for the scheme compared with 0.90% among ineligible households just south of the eligibility border (difference of 0.58 percentage points, 95% confidence interval 0.40 to 0.75; P<0.001). We found no difference in mortality rates for households above the poverty line (households above the poverty line were not eligible for the scheme), with a mortality rate from conditions covered by the scheme of 0.56% in eligible villages compared with 0.55% in ineligible villages (difference of 0.01 percentage points, -0.03 to 0.03; P=0.95). Eligible households had significantly reduced out-of-pocket health expenditures for admissions to hospitals with tertiary care facilities likely to be covered by the scheme (64% reduction, 35% to 97%; P<0.001). There was no significant increase in use of covered services, although the point estimate of a 44.2% increase approached significance (-5.1% to 90.5%; P=0.059). Both reductions in out-of-pocket expenditures and potential increases in use might have contributed to the observed reductions in mortality. Insuring poor households for efficacious but costly and underused health services significantly improves population health in India. © Sood et al 2014.

  7. Potential and Actual Neonatal Organ and Tissue Donation After Circulatory Determination of Death.

    PubMed

    Stiers, Justin; Aguayo, Cecile; Siatta, Angela; Presson, Angela P; Perez, Richard; DiGeronimo, Robert

    2015-07-01

    The need for transplants continues to exceed organ and tissue donor availability. Although recent surgical advances have resulted in successful transplants using very small pediatric donors, including neonates, the actual practice of neonatal organ donation after circulatory determination of death (DCDD) remains uncommon. To describe the percentage of neonates potentially eligible for DCDD, including those who underwent successful donation, and reasons for ineligibility in those who did not in a single neonatal intensive care unit (NICU). We obtained data from the Children's Hospital Neonatal Database and Intermountain Donor Services (IDS) organ procurement records. The 136 deaths that occurred in the NICU of the Primary Children's Hospital, Salt Lake City, Utah, from January 1, 2010, through May 7, 2013, were reviewed retrospectively from January 12 through July 1, 2014, to determine potential eligibility for DCDD as determined by IDS minimum eligibility criteria (requirement of life-sustaining interventions and weight >2 kg). For patients who did not undergo DCDD, we reviewed records to determine the reasons for ineligibility. Potential eligibility for DCDD among neonates who died in the study NICU. Of 136 deaths in the NICU, 60 (44.1%) met criteria for DCDD; however, fewer than 10% were referred appropriately to the regional organ procurement organization for evaluation. Forty-five neonates (33.1%) ultimately died within 90 minutes of withdrawal of life-sustaining interventions and thus would have been eligible for organ donation based on warm ischemic time. The most common causes of death among the 60 potentially eligible neonatal donors were neonatal encephalopathy (n = 17) and multiple congenital anomalies (n = 14). Nonreferral or late referral by the medical team was the most frequent reason for donor ineligibility, including 49 neonates (36.0%). Overall, only 4 neonates (2.9%) underwent successful DCDD. Although almost half of all neonatal deaths identified met minimum IDS criteria, most of these patients were not referred or were referred too late for evaluation. Although small size remains the primary reason for exclusion from DCDD, improved education with regard to criteria and the importance of timely referral by neonatologists and other members of the NICU team would likely result in a significant increase of future donations.

  8. Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.

    PubMed

    Watson, James; Taylor, Walter R J; Bancone, Germana; Chu, Cindy S; Jittamala, Podjanee; White, Nicholas J

    2018-04-01

    The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given standard regimens of primaquine and tafenoquine, respectively. Both drugs are currently considered contraindicated in pregnant and lactating women. Quantitative G6PD enzyme activity data from 5198 individuals were used to estimate the proportions of heterozygous females who would be ineligible for treatment at the 30% and 70% activity thresholds, and the relationship with the severity of the deficiency. This was used to construct a simple model relating allele frequency in males to the potential population coverage of tafenoquine and primaquine under current prescribing restrictions. Independent of G6PD deficiency, the current pregnancy and lactation restrictions will exclude ~13% of females from radical cure treatment. This could be reduced to ~4% if 8-aminoquinolines can be prescribed to women breast-feeding infants older than 1 month. At a 30% activity threshold, approximately 8-19% of G6PD heterozygous women are ineligible for primaquine treatment; at a 70% threshold, 50-70% of heterozygous women and approximately 5% of G6PD wild type individuals are ineligible for tafenoquine treatment. Thus, overall in areas where the G6PDd allele frequency is >10% more than 15% of men and more than 25% of women would be unable to receive tafenoquine. In vivax malaria infected patients these proportions will be lowered by any protective effect against P. vivax conferred by G6PD deficiency. If tafenoquine is deployed for radical cure, primaquine will still be needed to obtain high population coverage. Better radical cure antimalarial regimens are needed.

  9. 7 CFR 4288.112 - Eligibility notifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program... applicant a contract number. (b) Ineligibility notifications. If an applicant or a biofuel is determined by... after receipt of the application, as to the reason(s) the applicant or biofuel was determined to be...

  10. 11 CFR 9038.2 - Repayments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of the Commission's repayment determination under this section, the candidate should give preference... limited to, the following: (i) Payments made to the candidate after the candidate's date of ineligibility... determinations under 11 CFR 9038.2(b)(2) include, but are not limited to, the following: (A) Determinations that...

  11. 7 CFR 4274.319 - Ineligible loan purposes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... removing the violation. (k) Lending and investment institutions and insurance companies. (l) Golf courses... opportunities. (h) Community antenna television services or facilities. (i) Any illegal activity. (j) Any... activity when more than 10 percent of the annual gross revenue is derived from legalized gambling activity...

  12. 7 CFR 4274.319 - Ineligible loan purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... removing the violation. (k) Lending and investment institutions and insurance companies. (l) Golf courses... opportunities. (h) Community antenna television services or facilities. (i) Any illegal activity. (j) Any... activity when more than 10 percent of the annual gross revenue is derived from legalized gambling activity...

  13. 48 CFR 9.402 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policy. 9.402 Section 9... CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 9.402 Policy. (a) Agencies shall solicit... means to effectuate this policy. (b) The serious nature of debarment and suspension requires that these...

  14. 7 CFR 12.6 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Administration. 12.6 Section 12.6 Agriculture Office....6 Administration. (a) General. A determination of ineligibility for benefits in accordance with the... making such determinations, as provided in this section. (b) Administration by FSA. (1) The provisions of...

  15. 5 CFR 891.103 - Eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... FEDERAL EMPLOYEES HEALTH BENEFITS Administration and General Provisions § 891.103 Eligibility. (a) General conditions of eligibility. (1) A retired employee who is enrolled or covered by the enrollment of another... cost of a private health benefits plan. (2) A retired employee is ineligible to subscribe to the...

  16. 44 CFR 80.9 - Eligible and ineligible costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... source. (d) Negligence or other tortious conduct. FEMA acquisition funds are not available where an applicant, subapplicant, other project participant, or third party's negligence or intentional actions... negligence or other tortious conduct by a third party for causing such condition, they are responsible for...

  17. 46 CFR 272.23 - Examples of ineligible expenses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... loading of stores, the landing and sorting of laundry, pilot service, tug charges, removing surplus... or otherwise equip a vessel for its intended subsidized service which MARAD determines should have been performed before the initial entry of the vessel into subsidized service; (b) Convenience items...

  18. 42 CFR 68.10 - What loans are ineligible for repayment?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.10 What loans... Health Service Corps Scholarship Program, (6) National Institutes of Health Undergraduate Scholarship... following programs, or similar programs, which provide loans, scholarships, loan repayments, or other awards...

  19. 42 CFR 68.10 - What loans are ineligible for repayment?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., INTERNSHIPS, TRAINING NATIONAL INSTITUTES OF HEALTH (NIH) LOAN REPAYMENT PROGRAMS (LRPs) § 68.10 What loans... Health Service Corps Scholarship Program, (6) National Institutes of Health Undergraduate Scholarship... following programs, or similar programs, which provide loans, scholarships, loan repayments, or other awards...

  20. 7 CFR 12.6 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Administration. 12.6 Section 12.6 Agriculture Office....6 Administration. (a) General. A determination of ineligibility for benefits in accordance with the... making such determinations, as provided in this section. (b) Administration by FSA. (1) The provisions of...

  1. 7 CFR 12.6 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Administration. 12.6 Section 12.6 Agriculture Office....6 Administration. (a) General. A determination of ineligibility for benefits in accordance with the... making such determinations, as provided in this section. (b) Administration by FSA. (1) The provisions of...

  2. 7 CFR 1416.705 - Obligations of a participant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Eligible producers must execute all required documents and complete the 2005 Hurricane TAP funded practice... becomes ineligible for all or part of a 2005 Hurricane TAP benefit, the person and successor shall refund... site for the purpose of certifying compliance with 2005 Hurricanes TAP requirements. ...

  3. 41 CFR 109-45.601 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... surplus Government personal property by a debarred or suspended contractor. (d) The Deputy Assistant..., ABANDONMENT, OR DESTRUCTION OF PERSONAL PROPERTY 45.6-Debarred, Suspended, and Ineligible Contractors § 109-45.601 Policy. (a)-(b) [Reserved] (c) The Director, Office of Administrative Services and heads of field...

  4. 41 CFR 109-45.601 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... surplus Government personal property by a debarred or suspended contractor. (d) The Deputy Assistant..., ABANDONMENT, OR DESTRUCTION OF PERSONAL PROPERTY 45.6-Debarred, Suspended, and Ineligible Contractors § 109-45.601 Policy. (a)-(b) [Reserved] (c) The Director, Office of Administrative Services and heads of field...

  5. 41 CFR 109-45.601 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... surplus Government personal property by a debarred or suspended contractor. (d) The Deputy Assistant..., ABANDONMENT, OR DESTRUCTION OF PERSONAL PROPERTY 45.6-Debarred, Suspended, and Ineligible Contractors § 109-45.601 Policy. (a)-(b) [Reserved] (c) The Director, Office of Administrative Services and heads of field...

  6. 41 CFR 109-45.601 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... surplus Government personal property by a debarred or suspended contractor. (d) The Deputy Assistant..., ABANDONMENT, OR DESTRUCTION OF PERSONAL PROPERTY 45.6-Debarred, Suspended, and Ineligible Contractors § 109-45.601 Policy. (a)-(b) [Reserved] (c) The Director, Office of Administrative Services and heads of field...

  7. 41 CFR 109-45.601 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... surplus Government personal property by a debarred or suspended contractor. (d) The Deputy Assistant..., ABANDONMENT, OR DESTRUCTION OF PERSONAL PROPERTY 45.6-Debarred, Suspended, and Ineligible Contractors § 109-45.601 Policy. (a)-(b) [Reserved] (c) The Director, Office of Administrative Services and heads of field...

  8. 7 CFR 1430.209 - Proof of market loss production.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... may be obtained from the dairy operation's milk handler or marketing cooperative if deemed necessary... ineligibility for benefits under this subpart. (b) Eligible dairy operations marketing milk during the period... not limited to: milk marketing payment stubs, tank records, milk handler records, daily milk...

  9. 47 CFR 54.501 - Eligibility for services provided by telecommunications carriers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... schools, colleges, and universities) shall be eligible for discounts as libraries under this subpart. (3..., but not limited to, state colleges and state universities, state educational broadcasters, counties.... With one exception, eligible schools and libraries participating in consortia with ineligible private...

  10. Report: Grant No. X-824519-01 Awarded to the National Association of Minority Contractors

    EPA Pesticide Factsheets

    Report #2001-1-00203, September 27, 2001. We determined that of the $712,041 in EPA’s share of the costs incurred by NAMC under this grant, $456,873 of those costs were ineligible and $141,237 were unsupported.

  11. 76 FR 82075 - Highly Erodible Land and Wetland Conservation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... Wetland Conservation AGENCY: Office of the Secretary and Farm Service Agency, USDA. ACTION: Final rule. SUMMARY: Existing Department of Agriculture (USDA) regulations specify the conditions that may make a producer ineligible for certain USDA benefits, such as disaster assistance payments from the Farm Service...

  12. Management of relapsed/refractory classical Hodgkin lymphoma in transplant-ineligible patients.

    PubMed

    Mehta-Shah, Neha; Bartlett, Nancy L

    2018-04-12

    Addition of brentuximab vedotin, a CD30-targeted antibody-drug conjugate, and the programmed death 1 (PD-1) inhibitors nivolumab and pembrolizumab to the armamentarium for transplant-ineligible relapsed/refractory classical Hodgkin lymphoma has resulted in improved outcomes, including the potential for cure in a small minority of patients. For patients who have failed prior transplant or are unsuitable for dose-intense approaches based on age or comorbidities, an individualized approach with sequential use of single agents such as brentuximab vedotin, PD-1 inhibitors, everolimus, lenalidomide, or conventional agents such as gemcitabine or vinorelbine may result in prolonged survival with a minimal or modest effect on quality of life. Participation in clinical trials evaluating new approaches such as combination immune checkpoint inhibition, novel antibody-drug conjugates, or cellular therapies such as Epstein-Barr virus-directed cytotoxic T lymphocytes and chimeric antigen receptor T cells offer additional options for eligible patients. © 2018 by The American Society of Hematology.

  13. Old-Age Pension and Extended Families: How is Adult Children's Internal Migration Affected?

    PubMed Central

    Chen, Xi

    2017-01-01

    This paper makes use of the most recent social pension reform in rural China to examine whether receipt of the pension payment equips adult children of pensioners to migrate. Employing a regression discontinuity (hereafter RD) design to a primary longitudinal survey, this paper overcomes challenges in the literature that households eligible for pension payment might be systematically different from ineligible households and that it is difficult to separate the effect of pension from that of age or cohort heterogeneity. Around the pension eligibility age cut-off, results reveal large and significant increase among adult sons (but not daughters) to migrate out of their home county. Meanwhile, adult children are more likely to migrate out if their parents are healthy. Our Fuzzy RD estimations survive a standard set of key placebo tests and robustness checks. PMID:28408796

  14. Assessing paratransit eligibility under the Americans With Disabilities Act in the rehabilitation setting.

    PubMed

    Griffin, Jeanne; Priddy, David A

    2005-06-01

    To assess the usefulness of a rehabilitation-based assessment program designed to determine the eligibility, according to Americans With Disabilities Act criteria, of applicants for paratransit bus services. Retrospective summary statistics on 500 consecutive paratransit evaluations. Outpatient physical medicine and rehabilitation center. Applicants for a community paratransit bus service. Not applicable. Clinical assessment of each applicants functional physical and cognitive ability to ride a fixed-route or paratransit bus system. Of the 500 applicants for specialized paratransit services, 38 (8%) were found to be ineligible, based on rehabilitation professionals evaluations of their physical and cognitive abilities. Mass transit organizations must adjust to the rapidly growing demand for paratransit services. Rehabilitation-based assessment programs, because of the expertise they provide in assessing functional abilities, are uniquely qualified to provide objective determinations of paratransit eligibility.

  15. 34 CFR 361.81 - Applicable definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... per hour earnings in the week prior to exiting the vocational rehabilitation (VR) program of an...). This term includes home industry, farming, and other enterprises. Exit the VR program means that a DSU has closed the individual's record of VR services in one of the following categories: (1) Ineligible...

  16. 34 CFR 361.81 - Applicable definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... per hour earnings in the week prior to exiting the vocational rehabilitation (VR) program of an...). This term includes home industry, farming, and other enterprises. Exit the VR program means that a DSU has closed the individual's record of VR services in one of the following categories: (1) Ineligible...

  17. 32 CFR Appendix B to Part 47 - The DoD Civilian/Military Service Review Board and the Advisory Panel

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... break a tie. The board's decision is determined by majority vote. The president and two voting members... only needs to state the reasons why the group is ineligible for consideration under this part. 3. If...

  18. 48 CFR 309.407-3 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Procedures. 309.407-3 Section 309.407-3 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension, and Ineligibility 309.407-3 Procedures. (a) Investigation and referral. When an...

  19. 48 CFR 409.407-3 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Procedures. 409.407-3 Section 409.407-3 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE COMPETITION AND ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Debarment, Suspension and Ineligibility 409.407-3 Procedures. (a) Investigation and referral. When a...

  20. 75 FR 66665 - Program Integrity: Gainful Employment-New Programs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... where there is a record of poor performance sufficient to justify additional oversight. Along the same... ineligible status or otherwise be based on the performance of the institution's gainful employment programs... would enable institutions with good performance records to offer new programs more expediently. However...

  1. 34 CFR 361.81 - Applicable definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... per hour earnings in the week prior to exiting the vocational rehabilitation (VR) program of an...). This term includes home industry, farming, and other enterprises. Exit the VR program means that a DSU has closed the individual's record of VR services in one of the following categories: (1) Ineligible...

  2. 34 CFR 361.81 - Applicable definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... per hour earnings in the week prior to exiting the vocational rehabilitation (VR) program of an...). This term includes home industry, farming, and other enterprises. Exit the VR program means that a DSU has closed the individual's record of VR services in one of the following categories: (1) Ineligible...

  3. 34 CFR 361.81 - Applicable definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... per hour earnings in the week prior to exiting the vocational rehabilitation (VR) program of an...). This term includes home industry, farming, and other enterprises. Exit the VR program means that a DSU has closed the individual's record of VR services in one of the following categories: (1) Ineligible...

  4. 76 FR 56107 - Requiring Use of Electronic Services by Certain Claimant Representatives

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... ineligibility or personal preference, they can continue to use our paper processes and forms. Comment: A few... consider vocational factors; (3) * * * (ii) * * * This includes providing prompt and responsive answers to... need when we consider vocational factors; (3) * * * (ii) * * * This includes providing prompt and...

  5. 7 CFR 1709.112 - Ineligible grant purposes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... target community's proportionate share of a larger energy project. (c) Grant funds may not be used to... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES RUS High Energy Cost Grant Program § 1709.112..., structures or real property not directly associated with providing energy services in the target community...

  6. 7 CFR 1709.112 - Ineligible grant purposes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... target community's proportionate share of a larger energy project. (c) Grant funds may not be used to... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES RUS High Energy Cost Grant Program § 1709.112..., structures or real property not directly associated with providing energy services in the target community...

  7. 7 CFR 1709.112 - Ineligible grant purposes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... target community's proportionate share of a larger energy project. (c) Grant funds may not be used to... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES RUS High Energy Cost Grant Program § 1709.112..., structures or real property not directly associated with providing energy services in the target community...

  8. 7 CFR 1709.112 - Ineligible grant purposes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... target community's proportionate share of a larger energy project. (c) Grant funds may not be used to... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES RUS High Energy Cost Grant Program § 1709.112..., structures or real property not directly associated with providing energy services in the target community...

  9. 7 CFR 1709.112 - Ineligible grant purposes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... target community's proportionate share of a larger energy project. (c) Grant funds may not be used to... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES RUS High Energy Cost Grant Program § 1709.112..., structures or real property not directly associated with providing energy services in the target community...

  10. 7 CFR 12.4 - Determination of ineligibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General... such a field for conservation use; (2) The person produces an agricultural commodity on wetland that was converted after December 23, 1985; or (3) After November 28, 1990, the person converts a wetland...

  11. 7 CFR 12.4 - Determination of ineligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General... such a field for conservation use; (2) The person produces an agricultural commodity on wetland that was converted after December 23, 1985; or (3) After November 28, 1990, the person converts a wetland...

  12. 22 CFR 127.11 - Past violations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....S. criminal statutes enumerated in § 120.27 of this subchapter or who are ineligible to receive any... of the Assistant Secretary of State for Political-Military Affairs, that the applicant has taken... considered. If the Assistant Secretary of State for Political-Military Affairs concludes that the application...

  13. The Buckley Amendment and the Campus Press.

    ERIC Educational Resources Information Center

    Overbeck, Wayne

    1990-01-01

    Reviews controversies that have arisen at two California community colleges because campus newspapers were accused of violating the Buckley Amendment by publishing reports that student leaders were ineligible to hold their offices based on confidential academic records. Summarizes the Buckley Amendment and various court decisions related to…

  14. 43 CFR 9185.3-1 - Eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... governmental purpose to be subserved, no township is eligible for resurvey unless title to at least 50 percent... determining the eligibility of a township under this rule, lands covered by approved selections, school... alienated lands. Townships within the primary limits of railroad land grants are generally ineligible. (b...

  15. 31 CFR 5.17 - Will a debtor who owes a Treasury debt be ineligible for Federal loan assistance or Federal...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... disaster loans. Treasury entities may extend credit after the delinquency has been resolved. See 31 CFR 285.13 for standards defining when a “delinquency” is “resolved” for purposes of this prohibition. (b...

  16. 48 CFR 1552.209-74 - Limitation of future contracting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... an equal basis with other companies. (b) The Contractor will be ineligible to enter into a contract... subcontract under an EPA contract, which supports EPA's performance of Superfund Headquarters policy work... contract requires access to proprietary or confidential business or financial data of other companies, and...

  17. Dateline Child Care.

    ERIC Educational Resources Information Center

    Child Care Information Exchange, 1993

    1993-01-01

    Reports on the Clinton administration's budget decisions concerning Head Start and the Child Care and Development Block Grant; the Children's Defense Fund's support of Clinton administration policies; cuts in United Way aid to local charities; and the ineligibility of a center at which Bible stories are read to receive a Small Business…

  18. Recruitment of obese black women into a physical activity and nutrition intervention trial.

    PubMed

    Sharp, Lisa K; Fitzgibbon, Marian L; Schiffer, Linda

    2008-11-01

    Despite the increased health risks for obese Black women, relatively little research has explored physical activity and nutrition interventions for these women. This article describes the recruitment strategies used in a program designed specifically for obese Black women. Recruitment of Black women age 30 to 65 years with body mass indices between 30 kg/m2and 50 kg/m2was completed using in-person recruitment and flyers within 2 miles of the intervention site along with mass e-mails within the sponsoring university system. Medical clearance from a physician was an eligibility requirement because of Institutional Review Board safety concerns. Of the 690 women who were screened, 213 (31%) were eligible and randomized. The most common reason for exclusion was failure to return a medical clearance form (n = 167, 39% of ineligible). Different rates of efficiency were noted across recruitment approaches. Black women were successfully recruited using in-person community recruitment, e-mail, and community flyers within close proximity to the intervention site. Careful consideration should be given to the advantages and disadvantages of various recruitment strategies that might not generalize across studies.

  19. Measuring the effect of food stamps on food insecurity and hunger: research and policy considerations.

    PubMed

    Wilde, Parke E

    2007-02-01

    The federal government has estimated the prevalence of household "food insecurity" and "food insecurity with hunger" since 1995. Early observers believed that the new measure could be used to assess and improve the Food Stamp Program (FSP). Ten years of research have tempered the initial optimism. The prevalence of food insecurity with hunger (12.3% of all low-income households in 2004) is much higher among food stamp participant households (18.6% in 2004) than among low-income nonparticipant households (10.1% in 2004), due to strong self-selection effects. Households facing greater hardship are more likely to join the program. This article reviews 6 types of nonexperimental research designs that have been used to address the self-selection problem. The results have been inconclusive and the authors have warned against drawing causal inferences from their research. Ethical random-assignment research designs may be required to satisfy the intense policy interest in measuring the antihunger impact of the FSP. The most promising ethical research designs would test the effects of offering eligibility to households that are currently ineligible or offering increased benefits to households that are currently eligible for small benefit amounts.

  20. Cognitive dissonance and attitudes toward unpleasant medical screenings.

    PubMed

    Ent, Michael R; Gerend, Mary A

    2016-09-01

    Two studies suggest that cognitive dissonance can lead people to adopt negative attitudes toward beneficial-yet unpleasant-medical screenings. People who thought that they were candidates for an unpleasant medical screening reported less favorable attitudes toward the screening than people who thought that they were ineligible (Study 1). The unpleasantness of a medical screening affected candidates' attitudes toward the screening to a greater extent than non-candidate's attitudes (Study 2). Limitations, including ambiguity regarding the extent to which participants' attitudes were affected specifically by dissonance, are discussed. This preliminary research suggests people attempt to reduce dissonance associated with their anticipated behavior. © The Author(s) 2015.

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