Sample records for initial results demonstrate
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Adkins, Harold; Geelhood, Ken; Koeppel, Brian
2013-09-30
This document addresses Oak Ridge National Laboratory milestone M2FT-13OR0822015 Demonstration of Approach and Results on Used Nuclear Fuel Performance Characterization. This report provides results of the initial demonstration of the modeling capability developed to perform preliminary deterministic evaluations of moderate-to-high burnup used nuclear fuel (UNF) mechanical performance under normal conditions of storage (NCS) and normal conditions of transport (NCT) conditions. This report also provides results from the sensitivity studies that have been performed. Finally, discussion on the long-term goals and objectives of this initiative are provided.
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Initial Results of Illinois' Shifting Gears Pilot Demonstration Evaluation
ERIC Educational Resources Information Center
Bragg, Debra D.; Harmon, Timothy; Kirby, Catherine L.; Kim, Sujung
2009-01-01
This report provides initial results of Illinois' Shifting Gears Initiative that operated between July 1, 2007 and June 30, 2009. This mixed method (qualitative and quantitative) evaluation sought to accomplish three goals: (1) to assess program and student outcomes for two models (adult education and developmental education) for two target groups…
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Autonomous aircraft initiative study
NASA Technical Reports Server (NTRS)
Hewett, Marle D.
1991-01-01
The results of a consulting effort to aid NASA Ames-Dryden in defining a new initiative in aircraft automation are described. The initiative described is a multi-year, multi-center technology development and flight demonstration program. The initiative features the further development of technologies in aircraft automation already being pursued at multiple NASA centers and Department of Defense (DoD) research and Development (R and D) facilities. The proposed initiative involves the development of technologies in intelligent systems, guidance, control, software development, airborne computing, navigation, communications, sensors, unmanned vehicles, and air traffic control. It involves the integration and implementation of these technologies to the extent necessary to conduct selected and incremental flight demonstrations.
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The status and initial results of the Majorana demonstrator experiment
NASA Astrophysics Data System (ADS)
Guiseppe, V. E.; Abgrall, N.; Alvis, S. I.; Arnquist, I. J.; Avignone, F. T.; Barabash, A. S.; Barton, C. J.; Bertrand, F. E.; Bode, T.; Bradley, A. W.; Brudanin, V.; Busch, M.; Buuck, M.; Caldwell, T. S.; Chan, Y.-D.; Christofferson, C. D.; Chu, P.-H.; Cuesta, C.; Detwiler, J. A.; Dunagan, C.; Efremenko, Yu.; Ejiri, H.; Elliott, S. R.; Gilliss, T.; Giovanetti, G. K.; Green, M. P.; Gruszko, J.; Guinn, I. S.; Haufe, C. R.; Hehn, L.; Henning, R.; Hoppe, E. W.; Howe, M. A.; Keeter, K. J.; Kidd, M. F.; Konovalov, S. I.; Kouzes, R. T.; Lopez, A. M.; Martin, R. D.; Massarczyk, R.; Meijer, S. J.; Mertens, S.; Myslik, J.; O'Shaughnessy, C.; Othman, G.; Poon, A. W. P.; Radford, D. C.; Rager, J.; Reine, A. L.; Rielage, K.; Robertson, R. G. H.; Rouf, N. W.; Shanks, B.; Shirchenko, M.; Suriano, A. M.; Tedeschi, D.; Trimble, J. E.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yu, C.-H.; Yumatov, V.; Zhitnikov, I.; Zhu, B. X.
2017-10-01
Neutrinoless double-beta decay searches play a major role in determining the nature of neutrinos, the existence of a lepton violating process, and the effective Majorana neutrino mass. The Majorana Collaboration assembled an array of high purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. The Majorana Demonstrator is comprised of 44.1 kg (29.7 kg enriched in 76Ge) of Ge detectors divided between two modules contained in a low-background shield at the Sanford Underground Research Facility in Lead, South Dakota, USA. The initial goals of the Demonstrator are to establish the required background and scalability of a Ge-based next-generation ton-scale experiment. Following a commissioning run that started in 2015, the first detector module started low-background data production in early 2016. The second detector module was added in August 2016 to begin operation of the entire array. We discuss results of the initial physics runs, as well as the status and physics reach of the full Majorana Demonstrator experiment.
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ERIC Educational Resources Information Center
Littlefield, Lyn; Giese, Jill
2008-01-01
The Australian Government's Better Access to Mental Health Care initiative introduced mental health reforms that included the availability of Medicare-funded psychology services. The mental health initiative has resulted in a huge uptake of these services, demonstrating the strong community demand for psychological treatment. The initiative has…
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Demonstration of GTG as an alternative initiation codon for the serpin endopin 2B-2.
Hwang, Shin-Rong; Garza, Christina Z; Wegrzyn, Jill L; Hook, Vivian Y H
2005-02-18
This study demonstrates GTG as a novel, alternative initiation codon for translation of bovine endopin 2B-2, a serpin protease inhibitor. Molecular cDNA cloning revealed the endopin 2B-1 and endopin 2B-2 isoforms that are predicted to inhibit papain and elastase. Notably, GTG was demonstrated as the initiation codon for endopin 2B-2, whereas endopin 2B-1 possesses ATG as its initiation codon. GTG mediated in vitro translation of 46kDa endopin 2B-2. GTG also mediated translation of EGFP by in vitro translation and by expression in mammalian cells. Notably, mutagenesis of GTG to GTC resulted in the absence of EGFP expression in cells. GTG produced a lower level of protein expression compared to ATG. The use of GTG as an initiation codon to direct translation of endopin 2B, as well as the heterologous protein EGFP, demonstrates the role of GTG in the regulation of mRNA translation in mammalian cells. Significantly, further analyses of mammalian genomes based on GTG as an alternative initiation codon may predict new candidate gene products expressed by mammalian and human genomes.
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Sextant X-Ray Pulsar Navigation Demonstration: Initial On-Orbit Results
NASA Technical Reports Server (NTRS)
Mitchell, Jason W.; Winternitz, Luke M.; Hassouneh, Munther A.; Price, Samuel R.; Semper, Sean R.; Yu, Wayne H.; Ray, Paul S.; Wolff, Michael T.; Kerr, Matthew; Wood, Kent S.;
2018-01-01
The Station Explorer for X-ray Timing and Navigation Technology (SEXTANT) is a technology demonstration enhancement to the Neutron-star Interior Composition Explorer (NICER) mission. SEXTANT will be a first demonstration of in-space, autonomous, X-ray pulsar navigation (XNAV). Navigating using millisecond X-ray pulsars which could provide a GPS-like navigation capability available throughout our Solar System and beyond. NICER is a NASA Astrophysics Explorer Mission of Opportunity to the International Space Station that was launched and installed in June of 2017. During NICER's nominal 18-month base mission, SEXTANT will perform a number of experiments to demonstrate XNAV and advance the technology on a number of fronts. In this work, we review the SEXTANT, its goals, and present early results from SEXTANT experiments conducted in the first six months of operation. With these results, SEXTANT has made significant progress toward meeting its primary and secondary mission goals. We also describe the SEXTANT flight operations, calibration activities, and initial results.
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Initial Results from the Majorana Demonstrator
DOE Office of Scientific and Technical Information (OSTI.GOV)
Elliott, S. R.; Abgrall, N.; Arnquist, I. J.
Neutrinoless double-beta decay searches seek to determine the nature of neutrinos, the existence of a lepton violating process, and the eective Majorana neutrino mass. The Majorana Collaboration is assembling an array of high purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. The Majorana Demonstrator is composed of 44.8 kg (29.7 kg enriched in 76Ge) of Ge detectors in total, split between two modules contained in a low background shield at the Sanford Underground Research Facility in Lead, South Dakota. The initial goals of the Demonstrator are to establish the required background and scalability of a Ge-based, next-generation,more » tonne-scale experiment. Following a commissioning run that began in 2015, the rst detector module started physics data production in early 2016. We will discuss initial results of the Module 1 commissioning and rst physics run, as well as the status and potential physics reach of the full Majorana Demonstrator experiment. The collaboration plans to complete the assembly of the second detector module by mid-2016 to begin full data production with the entire array.« less
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Initial Results from the Majorana Demonstrator
NASA Astrophysics Data System (ADS)
Elliott, S. R.; Abgrall, N.; Arnquist, I. J.; Avignone, F. T., III.; Barabash, A. S.; Bertrand, F. E.; Bradley, A. W.; Brudanin, V.; Busch, M.; Buuck, M.; Caldwell, T. S.; Chan, Y.-D.; Christofferson, C. D.; Chu, P.-H.; Cuesta, C.; Detwiler, J. A.; Dunagan, C.; Efremenko, Yu.; Ejiri, H.; Fullmer, A.; Galindo-Uribarri, A.; Gilliss, T.; Giovanetti, G. K.; Green, M. P.; Gruszko, J.; Guinn, I. S.; Guiseppe, V. E.; Henning, R.; Hoppe, E. W.; Howe, M. A.; Jasinski, B. R.; Keeter, K. J.; Kidd, M. F.; Konovalov, S. I.; Kouzes, R. T.; Leon, J.; Lopez, A. M.; MacMullin, J.; Martin, R. D.; Massarczyk, R.; Meijer, S. J.; Mertens, S.; Orrell, J. L.; O'Shaughnessy, C.; Poon, A. W. P.; Radford, D. C.; Rager, J.; Rielage, K.; Robertson, R. G. H.; Romero-Romero, E.; Shanks, B.; Shirchenko, M.; Suriano, A. M.; Tedeschi, D.; Trimble, J. E.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yu, C.-H.; Yumatov, V.; Zhitnikov, I.
2017-09-01
Neutrinoless double-beta decay searches seek to determine the nature of neutrinos, the existence of a lepton violating process, and the effective Majorana neutrino mass. The Majorana Collaboration is assembling an array of high purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. The Majorana Demonstrator is composed of 44.8 kg (29.7 kg enriched in 76Ge) of Ge detectors in total, split between two modules contained in a low background shield at the Sanford Underground Research Facility in Lead, South Dakota. The initial goals of the Demonstrator are to establish the required background and scalability of a Ge-based, next-generation, tonne-scale experiment. Following a commissioning run that began in 2015, the first detector module started physics data production in early 2016. We will discuss initial results of the Module 1 commissioning and first physics run, as well as the status and potential physics reach of the full Majorana Demonstrator experiment. The collaboration plans to complete the assembly of the second detector module by mid-2016 to begin full data production with the entire array.
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Report: Strategic Agricultural Initiative Needs Revisions to Demonstrate Results
Report #2007-P-00040, September 26, 2007. The SAI program has not demonstrated how it fulfills its unique role of helping growers transition away from Food Quality Protection Act high-risk pesticides.
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Hwang, Shin-Rong; Garza, Christina Z; Wegrzyn, Jill; Hook, Vivian Y H
2004-08-16
This study demonstrates utilization of the novel GTG initiation codon for translation of a human mRNA transcript that encodes the serpin endopin 2B, a protease inhibitor. Molecular cloning revealed the nucleotide sequence of the human endopin 2B cDNA. Its deduced primary sequence shows high homology to bovine endopin 2A that possesses cross-class protease inhibition of elastase and papain. Notably, the human endopin 2B cDNA sequence revealed GTG as the predicted translation initiation codon; the predicted translation product of 46 kDa endopin 2B was produced by in vitro translation of 35S-endopin 2B with mammalian (rabbit) protein translation components. Importantly, bioinformatic studies demonstrated the presence of the entire human endopin 2B cDNA sequence with GTG as initiation codon within the human genome on chromosome 14. Further evidence for GTG as a functional initiation codon was illustrated by GTG-mediated in vitro translation of the heterologous protein EGFP, and by GTG-mediated expression of EGFP in mammalian PC12 cells. Mutagenesis of GTG to GTC resulted in the absence of EGFP expression in PC12 cells, indicating the function of GTG as an initiation codon. In addition, it was apparent that the GTG initiation codon produces lower levels of translated protein compared to ATG as initiation codon. Significantly, GTG-mediated translation of endopin 2B demonstrates a functional human gene product not previously predicted from initial analyses of the human genome. Further analyses based on GTG as an alternative initiation codon may predict new candidate genes of the human genome.
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Savvides, Andreas; Dieleman, Janneke A; van Ieperen, Wim; Marcelis, Leo F M
2016-04-01
Leaf initiation rate is largely determined by the apical bud temperature even when apical bud temperature largely deviates from the temperature of other plant organs. We have long known that the rate of leaf initiation (LIR) is highly sensitive to temperature, but previous studies in dicots have not rigorously demonstrated that apical bud temperature controls LIR independent of other plant organs temperature. Many models assume that apical bud and leaf temperature are the same. In some environments, the temperature of the apical bud, where leaf initiation occurs, may differ by several degrees Celsius from the temperature of other plant organs. In a 28-days study, we maintained temperature differences between the apical bud and the rest of the individual Cucumis sativus plants from -7 to +8 °C by enclosing the apical buds in transparent, temperature-controlled, flow-through, spheres. Our results demonstrate that LIR was completely determined by apical bud temperature independent of other plant organs temperature. These results emphasize the need to measure or model apical bud temperatures in dicots to improve the prediction of crop development rates in simulation models.
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Results from the first 4 years of pay for performance.
DeVore, Susan D
2010-01-01
Some of the lessons hospitals that have participated in the Hospital Quality Incentive Demonstration project have learned include: the need to tie in quality-of-care initiatives to the organization's strategic plan and to incentive plans for all employees, from executives on down; the value in allowing hospital physicians to "own" quality improvement initiatives; the importance of making results of the initiative available to all staff; the benefit of creating best-practice teams to address improvements in specific clinical areas.
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Chemical analysis of charged Li/SO(sub)2 cells
NASA Technical Reports Server (NTRS)
Subbarao, S.; Lawson, D.; Frank, H.; Halpert, G.; Barnes, J.; Bis, R.
1987-01-01
The initial focus of the program was to confirm that charging can indeed result in explosions and constitute a significant safety problem. Results of this initial effort clearly demonstrated that cells do indeed explode on charge and that charging does indeed constitute a real and severe safety problem. The results of the effort to identify the chemical reactions involved in and responsible for the observed behavior are described.
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Results of the Clarus Regional Demonstrations : Evaluation of Enhanced Road Weather Forecasting
DOT National Transportation Integrated Search
2012-01-01
The Clarus Initiative is a research effort of the U.S. Department of Transportation Intelligent Transportation Systems Joint Program Office and the Federal Highway Administrations Road Weather Management Program to develop and demonstrate an integ...
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Cognitive load during route selection increases reliance on spatial heuristics.
Brunyé, Tad T; Martis, Shaina B; Taylor, Holly A
2018-05-01
Planning routes from maps involves perceiving the symbolic environment, identifying alternate routes and applying explicit strategies and implicit heuristics to select an option. Two implicit heuristics have received considerable attention, the southern route preference and initial segment strategy. This study tested a prediction from decision-making theory that increasing cognitive load during route planning will increase reliance on these heuristics. In two experiments, participants planned routes while under conditions of minimal (0-back) or high (2-back) working memory load. In Experiment 1, we examined how memory load impacts the southern route heuristic. In Experiment 2, we examined how memory load impacts the initial segment heuristic. Results replicated earlier results demonstrating a southern route preference (Experiment 1) and initial segment strategy (Experiment 2) and further demonstrated that evidence for heuristic reliance is more likely under conditions of concurrent working memory load. Furthermore, the extent to which participants maintained efficient route selection latencies in the 2-back condition predicted the magnitude of this effect. Together, results demonstrate that working memory load increases the application of heuristics during spatial decision making, particularly when participants attempt to maintain quick decisions while managing concurrent task demands.
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NASA Astrophysics Data System (ADS)
Varghese, Babu; Bonito, Valentina; Turco, Simona; Verhagen, Rieko
2016-03-01
Laser induced optical breakdown (LIOB) is a non-linear absorption process leading to plasma formation at locations where the threshold irradiance for breakdown is surpassed. In this paper we experimentally demonstrate the influence of polarization and absorption on laser induced breakdown threshold in transparent, absorbing and scattering phantoms made from water suspensions of polystyrene microspheres. We demonstrate that radially polarized light yields a lower irradiance threshold for creating optical breakdown compared to linearly polarized light. We also demonstrate that the thermal initiation pathway used for generating seed electrons results in a lower irradiance threshold compared to multiphoton initiation pathway used for optical breakdown.
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Cosgrove, J W; Brown, I R
1984-05-01
An initiating cell-free protein synthesis system derived from brain was utilized to demonstrate that the intravenous injection of D-lysergic acid diethylamide (LSD) to rabbits resulted in a lesion at the initiation stage of brain protein synthesis. Three inhibitors of initiation, edeine, poly(I), and aurintricarboxylic acid were used to demonstrate a reduction in initiation-dependent amino acid incorporation in the brain cell-free system. One hour after LSD injection, there was also a measurable decrease in the formation of 40S and 80S initiation complexes in vitro, using either [35S]methionine or [35S]Met-tRNAf. Analysis of the methionine pool size after LSD administration indicated there was no change in methionine levels. Analysis of the formation of initiation complexes in the brain cell-free protein synthesis system prepared 6 h after LSD administration indicated that there was a return to control levels at this time. The effects of LSD on steps in the initiation process are thus reversible.
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40 CFR 63.707 - Reporting requirements.
Code of Federal Regulations, 2012 CFR
2012-07-01
...(c)(1) (material balance calculation) shall include with the notification of compliance status required by § 63.9(h) the results of the initial material balance calculation. (e) The owner or operator... nonregenerative carbon adsorber and demonstrating initial compliance in accordance with § 63.705(c)(6) shall...
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40 CFR 63.707 - Reporting requirements.
Code of Federal Regulations, 2011 CFR
2011-07-01
...(c)(1) (material balance calculation) shall include with the notification of compliance status required by § 63.9(h) the results of the initial material balance calculation. (e) The owner or operator... nonregenerative carbon adsorber and demonstrating initial compliance in accordance with § 63.705(c)(6) shall...
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40 CFR 63.707 - Reporting requirements.
Code of Federal Regulations, 2010 CFR
2010-07-01
...(c)(1) (material balance calculation) shall include with the notification of compliance status required by § 63.9(h) the results of the initial material balance calculation. (e) The owner or operator... nonregenerative carbon adsorber and demonstrating initial compliance in accordance with § 63.705(c)(6) shall...
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40 CFR 63.707 - Reporting requirements.
Code of Federal Regulations, 2013 CFR
2013-07-01
...(c)(1) (material balance calculation) shall include with the notification of compliance status required by § 63.9(h) the results of the initial material balance calculation. (e) The owner or operator... nonregenerative carbon adsorber and demonstrating initial compliance in accordance with § 63.705(c)(6) shall...
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40 CFR 63.707 - Reporting requirements.
Code of Federal Regulations, 2014 CFR
2014-07-01
...(c)(1) (material balance calculation) shall include with the notification of compliance status required by § 63.9(h) the results of the initial material balance calculation. (e) The owner or operator... nonregenerative carbon adsorber and demonstrating initial compliance in accordance with § 63.705(c)(6) shall...
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DOT National Transportation Integrated Search
2008-08-01
This report summarizes the efforts and results from four of six State-level demonstration projects supported with cooperative agreements from the National Highway Traffic Safety Administration. The projects were intended to increase seat belt use sta...
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E. Gardiner; J. Stanturf; T. Leininger; P. Hamel; L. Jr. Dorris; J. Portwood; J. Shepard
2008-01-01
As forest scientists increase their role in the process of science delivery, many research organizations are searching for novel methods to effectively build collaboration with managers to produce valued results. This article documents our experience with establishment of a forest restoration research and demonstration area in the Lower Mississippi Alluvial Valley (...
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A Polar Initial Alignment Algorithm for Unmanned Underwater Vehicles
Yan, Zheping; Wang, Lu; Wang, Tongda; Zhang, Honghan; Zhang, Xun; Liu, Xiangling
2017-01-01
Due to its highly autonomy, the strapdown inertial navigation system (SINS) is widely used in unmanned underwater vehicles (UUV) navigation. Initial alignment is crucial because the initial alignment results will be used as the initial SINS value, which might affect the subsequent SINS results. Due to the rapid convergence of Earth meridians, there is a calculation overflow in conventional initial alignment algorithms, making conventional initial algorithms are invalid for polar UUV navigation. To overcome these problems, a polar initial alignment algorithm for UUV is proposed in this paper, which consists of coarse and fine alignment algorithms. Based on the principle of the conical slow drift of gravity, the coarse alignment algorithm is derived under the grid frame. By choosing the velocity and attitude as the measurement, the fine alignment with the Kalman filter (KF) is derived under the grid frame. Simulation and experiment are realized among polar, conventional and transversal initial alignment algorithms for polar UUV navigation. Results demonstrate that the proposed polar initial alignment algorithm can complete the initial alignment of UUV in the polar region rapidly and accurately. PMID:29168735
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Initial Results from the Majorana Demonstrator
DOE Office of Scientific and Technical Information (OSTI.GOV)
Elliott, S. R.; Abgrall, N.; Arnquist, I. J.
The Majorana Collaboration has assembled an array of high purity Ge detectors to search for neutrinoless double-beta decay in 76Ge with the goal of establishing the required background and scalability of a Ge-based next-generation tonne-scale experiment. The Majorana Demonstrator consists of 44 kg of high-purity Ge (HPGe) detectors (30 kg enriched in 76Ge) with a low-noise p-type point contact (PPC) geometry. The detectors are split between two modules which are contained in a single lead and high-purity copper shield at the Sanford Underground Research Facility in Lead, South Dakota. Following a commissioning run that started in June 2015, the fullmore » detector array has been acquiring data since August 2016. We will discuss the status of the Majorana Demonstrator and initial results from the first physics run; including current background estimates, exotic low-energy physics searches, projections on the physics reach of the Demonstrator, and implications for a tonne-scale Ge based Neutrinoless double-beta decay search.« less
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Flight demonstration of laser diode initiated ordnance
NASA Technical Reports Server (NTRS)
Boucher, Craig J.; Schulze, Norman R.
1995-01-01
A program has been initiated by NASA Headquarters to validate laser initiated ordnance in flight applications. The primary program goal is to bring together a team of government and industry members to develop a laser initiated ordnance system having the test and analysis pedigree to be flown on launch vehicles. The culmination of this effort was a flight of the Pegasus launch vehicle which had two fin rockets initiated by this laser system. In addition, a laser initiated ordnance squib was fired into a pressure bomb during thrusting flight. The complete ordnance system comprising a laser diode firing unit, fiber optic cable assembly, laser initiated detonator, and laser initiated squib was designed and built by The Ensign Bickford Company. The hardware was tested to the requirements of the Pegasus launch vehicle and integrated into the vehicle by The Ensign Bickford Company and the Orbital Sciences Corporation. Discussions include initial program concept, contract implementation, team member responsibilities, analysis results, vehicle integration, safing architecture, ordnance interfaces, mission timeline and telemetry data. A complete system description, summary of the analyses, the qualification test results, and the results of flight are included.
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Code of Federal Regulations, 2010 CFR
2010-07-01
... compliance is not demonstrated using a performance test or design evaluation, you must demonstrate initial... performance tests or other initial compliance demonstrations? 63.7940 Section 63.7940 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS...
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Identifying and Articulating Library Connections to Student Success
ERIC Educational Resources Information Center
Massengale, Lisa; Piotrowski, Pattie; Savage, Devin
2016-01-01
Engaging in ongoing assessment is key to libraries demonstrating their value to their institutions. This study is an initial step in a STEM library's long-term goal of measuring the library's connection to, and impact on, student academic success markers such as retention and persistence. Initial results showed that any library usage was always…
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Learning From Tests: Facilitation of Delayed Recall by Initial Recognition Alternatives.
ERIC Educational Resources Information Center
Whitten, William B., II; Leonard, Janet Mauriello
1980-01-01
Two experiments were designed to determine the effects of multiple-choice recognition test alternatives on subsequent memory for the correct answers. Results of both experiments are interpreted as demonstrations of the principle that long-term retention is facilitated such that memory evaluation occurs during initial recognition tests. (Author/RD)
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INITIAL TEST RESULTS OF THE LIMESTONE INJECTION MULTISTAGE BURNER (LIMB) DEMONSTRATION PROJECT
The paper discusses SO2 removal efficiency and low-NOx burner performance obtained during short term tests, as well as the impact of LIMB ash on electrostatic precipitator (ESP) performance at Ohio Edison's Edgewater Station. Project goals are to demonstrate 50% or more SO2 remov...
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NASA Astrophysics Data System (ADS)
Colliver, Yeshe
2017-07-01
Children's early mathematical abilities are fundamental to their later academic achievement. An interest in mathematics in the early years is likely to establish a positive attitude to later mathematical learning, hopefully sustaining continued interest in mathematics and mathematical learning. Approaches to early mathematics teaching in the early years, however, are typically adult-initiated, which may fail to capture children's interest. Given the importance of children's motivation and sustained interest, the study described here strove to spark children's interests in mathematical problems in everyday life. The study sought to determine if children would incorporate more numeracy-related concepts into their free play if exposed to adult demonstrations of age-appropriate numeracy activities such as patterning. For at least 15 min three times weekly, participating children's parents and educators demonstrated numeracy problem-solving nearby, while children engaged in other activities. Demonstrations were thought to ascribe social value to the problem-solving activities. If children became interested in participating, adults told them to wait until the demonstrations finished, further indicating social value. Results show these children chose to play with numeracy-related activities in their free play time at preschool significantly more than children in a control group. These results suggest that seeking to foster children's interest in mathematics through child-initiated play, rather than prescribing adult-initiated mathematics activities, may be an important means of laying the foundation for lifelong mathematics learning. Ascribing social value to numeracy applications is proposed as a new approach to teaching mathematics in the early years.
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Body-borne IED detection: NATO DAT#10 BELCOAST 09 demonstration results
NASA Astrophysics Data System (ADS)
Alexander, Naomi; Gómez, Ignacio; Ortega, Isabel; Fiore, Franco; Coman, Cristian
2010-04-01
Belgium leads the tenth initiative in the CNAD Programme of Work for the Defense Against Terrorism (PoW DAT), dealing with Critical Infrastructure Protection (CIP). The BELCOAST 09 event, comprising a series of technology demonstrations, was organized to tackle the need for an event that brings together the operational, armaments and technological communities in the field of CIP. A counter terrorism scenario has been created: Terrorist with body-borne IED approaching the entrance of an installation, and a millimeter-wave imager's ability to detect IEDs has been demonstrated. The results of this scenario-based demonstration are presented in this paper.
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NASA Technical Reports Server (NTRS)
Wu, S. T.; Nakagawa, Y.; Han, S. M.; Dryer, M.
1982-01-01
The evolution of the magnetic field and the manner of conversion of thermal energy into different forms in the corona following a solar flare are investigated by means of a nonplane magnetohydrodynamic (MHD) analysis. All three components of magnetic field and velocity are treated in a physically self-consistent manner, with all physical variables as functions of time (t) and two spatial coordinates (r, theta). The difference arising from the initial magnetic field, either twisted (force-free) or non-twisted (potential), is demonstrated. Consideration is given to two initial field topologies (open vs. closed). The results demonstrate that the conversion of magnetic energy is faster for the case of the initially twisted (force-free) field than for the initially untwisted (potential) field. In addition, the twisted field is found to produce a complex structure of the density enhancements.
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Effect of text message follow-up on patient's self-reported level of pain and anxiety.
Keith, Daniel J; Rinchuse, Daniel J; Kennedy, Meghan; Zullo, Thomas
2013-07-01
To determine whether a text message reduces the severity of patient self-reported levels of pain and anxiety following initial placement of orthodontic appliances. Thirty-nine orthodontic patients were randomly assigned to one of two groups and matched for age, gender, and bracket type (self-ligating vs conventional). The subjects completed baseline questionnaires to ascertain their levels of pain and anxiety before initiating orthodontic treatment. Following the initial appointment, subjects completed the pain questionnaire and anxiety inventory at the same time daily for 1 week. One group received a structured text message showing concern and reassurance, while the second group served as a control and received no postprocedural communication. There was a statistically significant difference in pain in relation to time between the text message group and the control group as it was demonstrated that demonstrated that compared with the text message group, mean pain intensity increased and selfreported discomfort was longer in the control group. Anxiety was determined to be at its peak the day following initial orthodontic appliance placement and gradually tapered off from that time point. No intergroup difference was noted when analyzing anxiety. This study demonstrated that a text message sent from an orthodontic office following initial appliance placement resulted in a lower level of patient's self-reported pain. Additionally, patient anxiety is at its peak the day following the initial appointment and decreases from that point forward.
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Ash deposits - Initiating the change from empiricism to generic engineering. Part 2: Initial results
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wessel, R.A.; Wagoner, C.L.
1986-01-01
The goal is to develop and use calculations and measurements from several engineering disciplines that exceed the demonstrated limitations of present empirical techniques for predicting slagging/fouling behavior. In Part I of this paper, general relationships were presented for assessing effects of deposits and sootblowing on the real-time performance of heat transfer surfaces in pilot- and commercial-scale steam generators. In Part 2, these concepts are applied to the gas-side fouling of heat exchanger tubes. Deposition and heat transfer are calculated for superheater tubes in laboratory and utility furnaces. Numerical results for deposit thickness and heat flux are presented. Comparisons with datamore » show agreement, demonstrating that the broad-base engineering approach is promising.« less
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Mukherji, Suresh K
2014-04-01
An accountable care organization is a form of a managed care organization in which a group of networked health care providers, which may include hospitals, group practices, networks of practices, hospital-provider partnerships, or joint ventures, are accountable for the health care of a defined group of patients. Initial results of the institutions participating in CMS's Physician Group Demonstration Project did not demonstrate a substantial reduction in imaging that could be directly attributed to the accountable care organization model. However, the initial results suggest that incentive-based methodology appears to be successful for increasing compliance for measuring quality metrics. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.
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40 CFR 63.5722 - How do I use the performance test data to demonstrate initial compliance?
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I use the performance test data... Manufacturing Demonstrating Compliance for Open Molding Operations Controlled by Add-on Control Devices § 63.5722 How do I use the performance test data to demonstrate initial compliance? Demonstrate initial...
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40 CFR 63.5722 - How do I use the performance test data to demonstrate initial compliance?
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I use the performance test data... Manufacturing Demonstrating Compliance for Open Molding Operations Controlled by Add-on Control Devices § 63.5722 How do I use the performance test data to demonstrate initial compliance? Demonstrate initial...
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Initial Scene Representations Facilitate Eye Movement Guidance in Visual Search
ERIC Educational Resources Information Center
Castelhano, Monica S.; Henderson, John M.
2007-01-01
What role does the initial glimpse of a scene play in subsequent eye movement guidance? In 4 experiments, a brief scene preview was followed by object search through the scene via a small moving window that was tied to fixation position. Experiment 1 demonstrated that the scene preview resulted in more efficient eye movements compared with a…
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ERIC Educational Resources Information Center
Magnani, Natalia; Struffi, Lauro
2009-01-01
This article analyses the results of a European "research and demonstration" project promoting multifunctional and sustainable agriculture in Alpine regions through a participatory approach. It focuses in particular on initiatives undertaken by a local farmers group in the Italian Alpine area of Val di Sole, the purpose being to draw…
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Patterson, Stephanie Y; Elder, Lauren; Gulsrud, Amanda; Kasari, Connie
2014-01-01
Purpose This study examines the relationship between parental interaction style (responsive vs directive) and child-initiated joint engagement within caregiver–child interactions with toddlers diagnosed with autism spectrum disorders. Method Videotaped interactions of 85 toddler–caregiver dyads were coded for child engagement and both parental responsiveness and directiveness. Results Altogether, children spent less than one-third of the interaction jointly engaged. After controlling for child characteristics, parental style was associated with the initiator (child or parent) of joint engagement. Specifically, responsiveness predicted total time in child-initiated joint engagement, while directiveness predicted total time in parent-initiated joint engagement. Children’s social behaviours were associated with child-initiated joint engagement. Discussion Social initiations are a key target for children with autism spectrum disorders. Results demonstrate that child initiations and global social behaviour ratings are associated with parental responsivity. Responsivity may be a critical factor to facilitate children’s initiations. PMID:24104518
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Development of An Intelligent Flight Propulsion Control System
NASA Technical Reports Server (NTRS)
Calise, A. J.; Rysdyk, R. T.; Leonhardt, B. K.
1999-01-01
The initial design and demonstration of an Intelligent Flight Propulsion and Control System (IFPCS) is documented. The design is based on the implementation of a nonlinear adaptive flight control architecture. This initial design of the IFPCS enhances flight safety by using propulsion sources to provide redundancy in flight control. The IFPCS enhances the conventional gain scheduled approach in significant ways: (1) The IFPCS provides a back up flight control system that results in consistent responses over a wide range of unanticipated failures. (2) The IFPCS is applicable to a variety of aircraft models without redesign and,(3) significantly reduces the laborious research and design necessary in a gain scheduled approach. The control augmentation is detailed within an approximate Input-Output Linearization setting. The availability of propulsion only provides two control inputs, symmetric and differential thrust. Earlier Propulsion Control Augmentation (PCA) work performed by NASA provided for a trajectory controller with pilot command input of glidepath and heading. This work is aimed at demonstrating the flexibility of the IFPCS in providing consistency in flying qualities under a variety of failure scenarios. This report documents the initial design phase where propulsion only is used. Results confirm that the engine dynamics and associated hard nonlineaaities result in poor handling qualities at best. However, as demonstrated in simulation, the IFPCS is capable of results similar to the gain scheduled designs of the NASA PCA work. The IFPCS design uses crude estimates of aircraft behaviour. The adaptive control architecture demonstrates robust stability and provides robust performance. In this work, robust stability means that all states, errors, and adaptive parameters remain bounded under a wide class of uncertainties and input and output disturbances. Robust performance is measured in the quality of the tracking. The results demonstrate the flexibility of the IFPCS architecture and the ability to provide robust performance under a broad range of uncertainty. Robust stability is proved using Lyapunov like analysis. Future development of the IFPCS will include integration of conventional control surfaces with the use of propulsion augmentation, and utilization of available lift and drag devices, to demonstrate adaptive control capability under a greater variety of failure scenarios. Further work will specifically address the effects of actuator saturation.
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Particle Size Effects on CL-20 Initiation and Detonation
NASA Astrophysics Data System (ADS)
Valancius, Cole; Bainbridge, Joe; Love, Cody; Richardson, Duane
2017-06-01
Particle size or specific surface area effects on explosives has been of interest to the explosives community for both application and modeling of initiation and detonation. Different particles sizes of CL-20 were used in detonator experiments to determine the effects of particle size on initiation, run-up to steady state detonation, and steady state detonation. Historical tests have demonstrated a direct relationship between particle size and initiation. However, historical tests inadvertently employed density gradients, making it difficult to discern the effects of particle size from the effects of density. Density gradients were removed from these tests using a larger diameter, shorter charge column, allowing for similar loading across different particle sizes. Without the density gradient, the effects of particle size on initiation and detonation are easier to determine. The results of which contrast with historical results, showing particle size does not directly affect initiation threshold.
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Variability in University Students' Use of Technology: An "Approaches to Learning" Perspective
ERIC Educational Resources Information Center
Mimirinis, Mike
2016-01-01
This study reports the results of a cross-case study analysis of how students' approaches to learning are demonstrated in blended learning environments. It was initially propositioned that approaches to learning as key determinants of the quality of student learning outcomes are demonstrated specifically in how students utilise technology in…
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Yilmaz, Gulden; Biswas-Fiss, Esther E; Biswas, Subhasis B
2018-04-01
Human papillomaviruses (HPVs) encompass a large family of viruses that range from benign to highly carcinogenic. The crucial differences between benign and carcinogenic types of HPV remain unknown, except that the two HPV types differ in the frequency of DNA replication. We have systematically analyzed the mechanism of HPV DNA replication initiation in low-risk and high-risk HPVs. Our results demonstrate that HPV-encoded E2 initiator protein and its four binding sites in the replication origin play pivotal roles in determining the destiny of the HPV-infected cell. We have identified strain-specific single nucleotide variations in E2 binding sites found only in the high-risk HPVs. We have demonstrated that these variations result in attenuated formation of the E2-DNA complex. E2 binding to these sites is linked to the activation of the DNA replication origin as well as initiation of DNA replication. Both electrophoretic mobility shift assay and atomic force microscopy studies demonstrated that binding of E2 from either low- or high-risk HPVs with variant binding sequences lacked multimeric E2-DNA complex formation in vitro. These results provided a molecular basis of differential DNA replication in the two types of HPVs and pointed to a correlation with the development of cancer. Copyright © 2017. Published by Elsevier B.V.
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Evolutionary Initial Poses of Reduced D.O.F’s Quadruped Robot
NASA Astrophysics Data System (ADS)
Iida, Ken-Ichi; Nakata, Yoshitaka; Hira, Toshio; Kamano, Takuya; Suzuki, Takayuki
In this paper, an application of genetic algorithm for generation of evolutionary initial poses of a quadrupedal robot which reduced degrees of freedom is described. To reduce degree of freedom, each leg of the robot has a slider-crank mechanism and is driven by an actuator. Furthermore we introduced the forward movement mode and the rotating mode because the omnidirection movement should be made possible. To generate the suitable initial pose, the initial angle of four legs are coded under gray code and tuned by an estimation function in each mode with the genetic algorithm. As a result of generation, the cooperation of the legs is realized to move toward the omnidirection. The experimental results demonstrate that the proposed scheme is effective for generation of the suitable initial poses and the robot can walk smoothly with the generated patterns.
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Code of Federal Regulations, 2013 CFR
2013-07-01
... tests upon initial startup or no later than 180 calendar days after the compliance date that is... conduct initial compliance demonstrations that do not require performance tests upon initial startup or no...
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Characterization of feeding-delaying factors from the silkworm Bombyx mori.
Nagata, Shinji; Morooka, Nobukatsu; Matsumoto, Sumihiro; Nagasawa, Hiromichi
2009-04-01
In several phytophagous insects, feeding behavior occurs regularly. Recently, we demonstrated that feeding behavior in larvae of the silkworm Bombyx mori had a regular frequency. To address the control of the feeding cycle in B. mori, we aimed to characterize factors influencing feeding initiation and termination. Injection of extracts of the midgut, foregut, and fat body into starved Bombyx larvae delayed the initiation of feeding. This result indicates the presence in these tissues of factors capable of decreasing the likelihood of feeding initiation.
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Overview of Additive Manufacturing Initiatives at NASA Marshall Space Flight Center
NASA Technical Reports Server (NTRS)
Clinton, R. G., Jr.
2018-01-01
NASA's In Space Manufacturing Initiative (ISM) includes: The case for ISM - why; ISM path to exploration - results from the 3D Printing In Zero-G Technology Demonstration - ISM challenges; In space Robotic Manufacturing and Assembly (IRMA); Additive construction. Additively Manufacturing (AM) development for liquid rocket engine space flight hardware. MSFC standard and specification for additively manufactured space flight hardware. Summary.
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Small deformations of extreme five dimensional Myers-Perry black hole initial data
NASA Astrophysics Data System (ADS)
Alaee, Aghil; Kunduri, Hari K.
2015-02-01
We demonstrate the existence of a one-parameter family of initial data for the vacuum Einstein equations in five dimensions representing small deformations of the extreme Myers-Perry black hole. This initial data set has `' symmetry and preserves the angular momenta and horizon geometry of the extreme solution. Our proof is based upon an earlier result of Dain and Gabach-Clement concerning the existence of -invariant initial data sets which preserve the geometry of extreme Kerr (at least for short times). In addition, we construct a general class of transverse, traceless symmetric rank 2 tensors in these geometries.
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Hybrid tracking and control system for computer-aided retinal surgery
NASA Astrophysics Data System (ADS)
Ferguson, R. D.; Wright, Cameron H. G.; Rylander, Henry G., III; Welch, Ashley J.; Barrett, Steven F.
1996-05-01
We describe initial experimental results of a new hybrid digital and analog design for retinal tracking and laser beam control. Initial results demonstrate tracking rates which exceed the equivalent of 50 degrees per second in the eye, with automatic lesion pattern creation and robust loss of lock detection. Robotically assisted laser surgery to treat conditions such as diabetic retinopathy, macular degeneration, and retinal tears can now be realized under clinical conditions with requisite safety using standard video hardware and inexpensive optical components.
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DOT National Transportation Integrated Search
1998-11-01
The purpose of this working paper is to present estimates of potential safety benefits resulting from full implementation of Intelligent Transportation Systems (ITS) in the United States. These estimates were derived by integrating results from a num...
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Initial results from the Solar Dynamic (SD) Ground Test Demonstration (GTD) project at NASA Lewis
NASA Technical Reports Server (NTRS)
Shaltens, Richard K.; Boyle, Robert V.
1995-01-01
A government/industry team designed, built, and tested a 2 kWe solar dynamic space power system in a large thermal/vacuum facility with a simulated sun at the NASA Lewis Research Center. The Lewis facility provides an accurate simulation of temperatures, high vacuum, and solar flux as encountered in low earth orbit. This paper reviews the goals and status of the Solar Dynamic (SD) Ground Test Demonstration (GTD) program and describes the initial testing, including both operational and performance data. This SD technology has the potential as a future power source for the International Space Station Alpha.
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Flippo, K. A.; Doss, F. W.; Kline, J. L.; ...
2016-11-23
While using a large volume high-energy-density fluid shear experiment ( 8.5 cm 3 ) at the National Ignition Facility, we have demonstrated for the first time the ability to significantly alter the evolution of a supersonic sheared mixing layer by controlling the initial conditions of that layer. Furthermore, by altering the initial surface roughness of the tracer foil, we demonstrate the ability to transition the shear mixing layer from a highly ordered system of coherent structures to a randomly ordered system with a faster growing mix layer, indicative of strong mixing in the layer at a temperature of severalmore » tens of electron volts and at near solid density. Moreover, simulations using a turbulent-mix model show good agreement with the experimental results and poor agreement without turbulent mix.« less
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Short time propagation of a singular wave function: Some surprising results
NASA Astrophysics Data System (ADS)
Marchewka, A.; Granot, E.; Schuss, Z.
2007-08-01
The Schrödinger evolution of an initially singular wave function was investigated. First it was shown that a wide range of physical problems can be described by initially singular wave function. Then it was demonstrated that outside the support of the initial wave function the time evolution is governed to leading order by the values of the wave function and its derivatives at the singular points. Short-time universality appears where it depends only on a single parameter—the value at the singular point (not even on its derivatives). It was also demonstrated that the short-time evolution in the presence of an absorptive potential is different than in the presence of a nonabsorptive one. Therefore, this dynamics can be harnessed to the determination whether a potential is absorptive or not simply by measuring only the transmitted particles density.
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Richards, Katherine; Singletary, Floris; Rothi, Leslie J Gonzalez; Koehler, Shirley; Crosson, Bruce
2002-01-01
Intentional mechanisms play an important role in complex self-initiated actions, such as language and gesturing. Deficits demonstrated in nonfluent aphasia may be a result of a disconnection between or damage to the initiation (intention) and production mechanisms in the left hemisphere. In chronic nonfluent aphasias, damaged language production mechanisms in the left hemisphere may switch to homologous regions in the right hemisphere while the initiation mechanisms remain active in the left hemisphere. A treatment was developed to prime right-hemisphere initiation mechanisms with movements of the nondominant hand, thereby bringing initiation into the right hemisphere where the language production mechanisms have been shifted. Three subjects with stable, chronic nonfluent aphasias were trained in daily sessions with a therapist to perform a complex nonsymbolic movement sequence with their nondominant hand to initiate naming trials of simple line drawings. Naming probes were administered during pre treatment baseline sessions and before each treatment session. All three subjects demonstrated a stable baseline and a significant increase over baseline performance in the percentage correct on naming probes during the treatment. Findings indicate that more extensive investigations of this newly developed treatment are justified and suggest that activation of right-hemisphere initiation mechanisms may enhance word production accuracy in stable, chronic nonfluent aphasias.
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Siegel, Adam J; Fondrk, M Kim; Amdam, Gro V; Page, Robert E
2013-01-01
Honey bee workers exhibit an age-based division of labor (temporal polyethism, DOL). Younger bees transition through sets of tasks within the nest; older bees forage outside. Components of temporal polyethism remain unrevealed. Here, we investigate the timing and pattern of pre-foraging behavior in distinct strains of bees to (1) determine if a general pattern of temporal DOL exists in honey bees, (2) to demonstrate a direct genetic impact on temporal pacing, and (3) to further elucidate the mechanisms controlling foraging initiation. Honey bees selected for differences in stored pollen demonstrate consistent differences in foraging initiation age. Those selected for increased pollen storage (high pollen hoarding strain, HSBs) initiate foraging earlier in life than those selected for decreased pollen storage (low pollen hoarding strain, LSBs). We found that HSBs both initiate and terminate individual pre-foraging tasks earlier than LSBs when housed in a common hive environment. Unselected commercial bees (wild type) generally demonstrated intermediate behavioral timing. There were few differences between genotypes for the proportion of pre-foraging effort dedicated to individual tasks, though total pre-foraging effort differences differed dramatically. This demonstrates that behavioral pacing can be accelerated or slowed, but the pattern of behavior is not fundamentally altered, suggesting a general pattern of temporal behavior in honey bees. This also demonstrates direct genetic control of temporal pacing. Finally, our results suggest that earlier HSB protein (pollen) consumption termination compared to LSBs may contribute to an earlier decline in hemolymph vitellogenin protein titers, which would explain their earlier onset of foraging.
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Code of Federal Regulations, 2011 CFR
2011-07-01
... must I use to demonstrate initial compliance with the emission limits for particulate matter? 63.7822... demonstrate initial compliance with the emission limits for particulate matter? (a) You must conduct each... applicable emission limit for particulate matter in Table 1 to this subpart, follow the test methods and...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... must I use to demonstrate initial compliance with the emission limits for particulate matter? 63.7822... demonstrate initial compliance with the emission limits for particulate matter? (a) You must conduct each... applicable emission limit for particulate matter in Table 1 to this subpart, follow the test methods and...
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Inhibition of chaotic escape from a potential well by incommensurate escape-suppressing excitations.
Chacón, R; Martínez, J A
2002-03-01
Theoretical results are presented concerning the reduction of chaotic escape from a potential well by means of a harmonic parametric excitation that satisfies an ultrasubharmonic resonance condition with the escape-inducing excitation. The possibility of incommensurate escape-suppressing excitations is demonstrated by studying rational approximations to the irrational escape-suppressing frequency. The analytical predictions for the suitable amplitudes and initial phases of the escape-suppressing excitation are tested against numerical simulations based on a high-resolution grid of initial conditions. These numerical results indicate that the reduction of escape is reliably achieved for small amplitudes and at, and only at, the predicted initial phases. For the case of irrational escape-suppressing frequencies, the effective escape-reducing initial phases are found to lie close to the accumulation points of the set of suitable initial phases that are associated with the complete series of convergents up to the convergent giving the chosen rational approximation.
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NASA Technical Reports Server (NTRS)
Pandya, Mohagna J.; Baysal, Oktay
1997-01-01
A gradient-based shape optimization based on quasi-analytical sensitivities has been extended for practical three-dimensional aerodynamic applications. The flow analysis has been rendered by a fully implicit, finite-volume formulation of the Euler and Thin-Layer Navier-Stokes (TLNS) equations. Initially, the viscous laminar flow analysis for a wing has been compared with an independent computational fluid dynamics (CFD) code which has been extensively validated. The new procedure has been demonstrated in the design of a cranked arrow wing at Mach 2.4 with coarse- and fine-grid based computations performed with Euler and TLNS equations. The influence of the initial constraints on the geometry and aerodynamics of the optimized shape has been explored. Various final shapes generated for an identical initial problem formulation but with different optimization path options (coarse or fine grid, Euler or TLNS), have been aerodynamically evaluated via a common fine-grid TLNS-based analysis. The initial constraint conditions show significant bearing on the optimization results. Also, the results demonstrate that to produce an aerodynamically efficient design, it is imperative to include the viscous physics in the optimization procedure with the proper resolution. Based upon the present results, to better utilize the scarce computational resources, it is recommended that, a number of viscous coarse grid cases using either a preconditioned bi-conjugate gradient (PbCG) or an alternating-direction-implicit (ADI) method, should initially be employed to improve the optimization problem definition, the design space and initial shape. Optimized shapes should subsequently be analyzed using a high fidelity (viscous with fine-grid resolution) flow analysis to evaluate their true performance potential. Finally, a viscous fine-grid-based shape optimization should be conducted, using an ADI method, to accurately obtain the final optimized shape.
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NASA Astrophysics Data System (ADS)
Tao, Ling-Jiang; Gao, Chuan; Zhang, Rong-Hua
2018-07-01
Previous studies indicate that ENSO predictions are particularly sensitive to the initial conditions in some key areas (socalled "sensitive areas"). And yet, few studies have quantified improvements in prediction skill in the context of an optimal observing system. In this study, the impact on prediction skill is explored using an intermediate coupled model in which errors in initial conditions formed to make ENSO predictions are removed in certain areas. Based on ideal observing system simulation experiments, the importance of various observational networks on improvement of El Niño prediction skill is examined. The results indicate that the initial states in the central and eastern equatorial Pacific are important to improve El Ni˜no prediction skill effectively. When removing the initial condition errors in the central equatorial Pacific, ENSO prediction errors can be reduced by 25%. Furthermore, combinations of various subregions are considered to demonstrate the efficiency on ENSO prediction skill. Particularly, seasonally varying observational networks are suggested to improve the prediction skill more effectively. For example, in addition to observing in the central equatorial Pacific and its north throughout the year, increasing observations in the eastern equatorial Pacific during April to October is crucially important, which can improve the prediction accuracy by 62%. These results also demonstrate the effectiveness of the conditional nonlinear optimal perturbation approach on detecting sensitive areas for target observations.
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Carroll-Scott, Amy; Toy, Peggy; Wyn, Roberta; Zane, Jazmin I.; Wallace, Steven P.
2012-01-01
Objectives. In an era of community-based participatory research and increased expectations for evidence-based practice, we evaluated an initiative designed to increase community-based organizations’ data and research capacity through a 3-day train-the-trainer course on community health assessments. Methods. We employed a mixed method pre–post course evaluation design. Various data sources collected from 171 participants captured individual and organizational characteristics and pre–post course self-efficacy on 19 core skills, as well as behavior change 1 year later among a subsample of participants. Results. Before the course, participants reported limited previous experience with data and low self-efficacy in basic research skills. Immediately after the course, participants demonstrated statistically significant increases in data and research self-efficacy. The subsample reported application of community assessment skills to their work and increased use of data 1 year later. Conclusions. Results suggest that an intensive, short-term training program can achieve large immediate gains in data and research self-efficacy in community-based organization staff. In addition, they demonstrate initial evidence of longer-term behavior change related to use of data and research skills to support their community work. PMID:22594748
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Assessment of MARMOT Grain Growth Model
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fromm, B.; Zhang, Y.; Schwen, D.
2015-12-01
This report assesses the MARMOT grain growth model by comparing modeling predictions with experimental results from thermal annealing. The purpose here is threefold: (1) to demonstrate the validation approach of using thermal annealing experiments with non-destructive characterization, (2) to test the reconstruction capability and computation efficiency in MOOSE, and (3) to validate the grain growth model and the associated parameters that are implemented in MARMOT for UO 2. To assure a rigorous comparison, the 2D and 3D initial experimental microstructures of UO 2 samples were characterized using non-destructive Synchrotron x-ray. The same samples were then annealed at 2273K for grainmore » growth, and their initial microstructures were used as initial conditions for simulated annealing at the same temperature using MARMOT. After annealing, the final experimental microstructures were characterized again to compare with the results from simulations. So far, comparison between modeling and experiments has been done for 2D microstructures, and 3D comparison is underway. The preliminary results demonstrated the usefulness of the non-destructive characterization method for MARMOT grain growth model validation. A detailed analysis of the 3D microstructures is in progress to fully validate the current model in MARMOT.« less
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Preliminary Results form the Japanese Total Lightning Network
NASA Astrophysics Data System (ADS)
Hobara, Y.; Ishii, H.; Kumagai, Y.; Liu, C.; Heckman, S.; Price, C. G.; Williams, E. R.
2015-12-01
We report on the initial observational results from the first Japanese Total Lightning Detection Network (JTLN) in relation to severe weather phenomena. The University of Electro-Communications (UEC) has deployed the Earth Networks (EN) Total Lightning System over Japan to carry out research on the relationship between thunderstorm activity and severe weather phenomena since 2013. In this paper we first demonstrate the current status of our new network followed by the initial scientific results. The lightning jump algorithm was applied to our total lightning data to study the relationship between total lighting activity and hazardous weather events such as gust fronts and tornadoes over land reported by the JMA (Japanese Meteorological Agency) in 2014. As a result, a clear increase in total lighting flash rate as well as lightning jumps are observed prior to most hazardous weather events (~20 min) indicating potential usefulness for early warning in Japan. Furthermore we are going to demonstrate the relationship of total lightning activities with meteorological radar data focusing particularly on Japanese Tornadic storms.
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Compressed natural gas fuel use training manual
DOT National Transportation Integrated Search
1992-09-01
The Urban Mass Transportation Administration (UMTA) Alternative Fuel Initiative and the Environmental Protection Agency (EPA) 1991 regulations on transit bus exhaust emissions has resulted in a number of alternative fueled transit bus demonstrations....
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Facility uses Six Sigma to improve quality.
2006-09-01
Initiative demonstrates a 23% improvement in first bed assignment to a private isolation room. Keys to improvement found in enhanced communication and staff training. Staff develop reporting mechanism to sustain and institutionalize project results.
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Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 13 2012-07-01 2012-07-01 false How do I demonstrate initial compliance with the emission limitations if I monitor brew ethanol? 63.2166 Section 63.2166 Protection of... ethanol? (a) You must demonstrate initial compliance with each emission limitation that applies to you...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 13 2014-07-01 2014-07-01 false How do I demonstrate initial compliance with the emission limitations if I monitor brew ethanol? 63.2166 Section 63.2166 Protection of... ethanol? (a) You must demonstrate initial compliance with each emission limitation that applies to you...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I demonstrate initial compliance with the emission limitations if I monitor brew ethanol? 63.2166 Section 63.2166 Protection of... ethanol? (a) You must demonstrate initial compliance with each emission limitation that applies to you...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... must I use to demonstrate initial compliance with dioxin/furan emission limits? 63.9915 Section 63.9915....9915 What test methods and other procedures must I use to demonstrate initial compliance with dioxin... limit for dioxins/furans in Table 1 to this subpart, you must follow the test methods and procedures...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... initial performance tests or other initial compliance demonstrations if I own or operate a stationary RICE... performance tests or other initial compliance demonstrations if I own or operate a stationary RICE with a site... stationary RICE with a site rating of more than 500 brake HP located at a major source of HAP emissions you...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... initial performance tests or other initial compliance demonstrations if I own or operate a stationary RICE... performance tests or other initial compliance demonstrations if I own or operate a stationary RICE with a site... stationary RICE with a site rating of more than 500 brake HP located at a major source of HAP emissions you...
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Lunar rover technology demonstrations with Dante and Ratler
NASA Technical Reports Server (NTRS)
Krotkov, Eric; Bares, John; Katragadda, Lalitesh; Simmons, Reid; Whittaker, Red
1994-01-01
Carnegie Mellon University has undertaken a research, development, and demonstration program to enable a robotic lunar mission. The two-year mission scenario is to traverse 1,000 kilometers, revisiting the historic sites of Apollo 11, Surveyor 5, Ranger 8, Apollo 17, and Lunokhod 2, and to return continuous live video amounting to more than 11 terabytes of data. Our vision blends autonomously safeguarded user driving with autonomous operation augmented with rich visual feedback, in order to enable facile interaction and exploration. The resulting experience is intended to attract mass participation and evoke strong public interest in lunar exploration. The encompassing program that forwards this work is the Lunar Rover Initiative (LRI). Two concrete technology demonstration projects currently advancing the Lunar Rover Initiative are: (1) The Dante/Mt. Spurr project, which, at the time of this writing, is sending the walking robot Dante to explore the Mt. Spurr volcano, in rough terrain that is a realistic planetary analogue. This project will generate insights into robot system robustness in harsh environments, and into remote operation by novices; and (2) The Lunar Rover Demonstration project, which is developing and evaluating key technologies for navigation, teleoperation, and user interfaces in terrestrial demonstrations. The project timetable calls for a number of terrestrial traverses incorporating teleoperation and autonomy including natural terrain this year, 10 km in 1995. and 100 km in 1996. This paper will discuss the goals of the Lunar Rover Initiative and then focus on the present state of the Dante/Mt. Spurr and Lunar Rover Demonstration projects.
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2013-12-01
Demonstration Project beginning in the 2011 North Atlantic hurricane season (WG/HWSOR 2011). The primary objectives of the first year of the demon- stration...after Atlantic hurricanes from WP-3D hur- ricane research flights conducted jointly by the NOAA AircraftOperationsCenter (AOC), theNOAA/Hurricane... Atlantic hurricane season; 3) to present an initial set of results from the inclusion of AXBT data in both statistical and dynamical numerical prediction
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NASA Astrophysics Data System (ADS)
Schulze, Norman R.; Maxfield, B.; Boucher, C.
1995-01-01
Solid State Laser Initiated Ordnance (LIO) offers new technology having potential for enhanced safety, reduced costs, and improved operational efficiency. Concerns over the absence of programmatic applications of the technology, which has prevented acceptance by flight programs, should be abated since LIO has now been operationally implemented by the Laser Initiated Ordnance Sounding Rocket Demonstration (LOSRD) Program. The first launch of solid state laser diode LIO at the NASA Wallops Flight Facility (WFF) occurred on March 15, 1995 with all mission objectives accomplished. This project, Phase 3 of a series of three NASA Headquarters LIO demonstration initiatives, accomplished its objective by the flight of a dedicated, all-LIO sounding rocket mission using a two-stage Nike-Orion launch vehicle. LIO flight hardware, made by The Ensign-Bickford Company under NASA's first Cooperative Agreement with Profit Making Organizations, safely initiated three demanding pyrotechnic sequence events, namely, solid rocket motor ignition from the ground and in flight, and flight termination, i.e., as a Flight Termination System (FTS). A flight LIO system was designed, built, tested, and flown to support the objectives of quickly and inexpensively putting LIO through ground and flight operational paces. The hardware was fully qualified for this mission, including component testing as well as a full-scale system test. The launch accomplished all mission objectives in less than 11 months from proposal receipt. This paper concentrates on accomplishments of the ordnance aspects of the program and on the program's implementation and results. While this program does not generically qualify LIO for all applications, it demonstrated the safety, technical, and operational feasibility of those two most demanding applications, using an all solid state safe and arm system in critical flight applications.
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The Natural History of Neoplasia
Pitot, Henry C.
1977-01-01
The stages of initiation and promotion in the natural history of epidermal carcinogenesis have been known for many years. Recently, experimental systems other than skin have been shown to exhibit similar, if not completely analogous, stages in the natural history of neoplasia. In particular, the demonstration by Peraino and his associates that phenobarbital may enhance the production of hepatomas by a relatively subcarcinogenic dose of acetylaminofluorene was one of the first demonstrations of stages occurring in an extraepidermal neoplasm. Studies reported in this paper have demonstrated that administration of phenobarbital (0.05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas. This was compared to animals receiving only a single dose of diethylnitrosamine following partial hepatectomy with no further treatment, in which only a relatively small number of foci were evident in the absence of phenobarbital feeding. Using three different enzyme markers, a distinct degree of phenotypic heterogeneity of the enzyme-altered foci in liver was demonstrated. These studies have shown that liver carcinogensis can be readily divided into two stages: a) initiation by a single dose of diethylnitrosamine following partial hepatectomy and b) promotion by the continuous feeding of phenobarbital. Furthermore, the immediate progeny of the initiated cells, the enzyme-altered focus, may be recognized by suitable microscopic means prior to the formation of gross lesions as required in the skin system. These initiated cell populations exhibit a degree of biochemical heterogeneity which reflects that seen in fully developed hepatic neoplasms, suggesting that promotion and progression in this system does not significantly alter the basic biochemical characteristics of the initiated cell. PMID:21565
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Probability distributions of continuous measurement results for conditioned quantum evolution
NASA Astrophysics Data System (ADS)
Franquet, A.; Nazarov, Yuli V.
2017-02-01
We address the statistics of continuous weak linear measurement on a few-state quantum system that is subject to a conditioned quantum evolution. For a conditioned evolution, both the initial and final states of the system are fixed: the latter is achieved by the postselection in the end of the evolution. The statistics may drastically differ from the nonconditioned case, and the interference between initial and final states can be observed in the probability distributions of measurement outcomes as well as in the average values exceeding the conventional range of nonconditioned averages. We develop a proper formalism to compute the distributions of measurement outcomes, and evaluate and discuss the distributions in experimentally relevant setups. We demonstrate the manifestations of the interference between initial and final states in various regimes. We consider analytically simple examples of nontrivial probability distributions. We reveal peaks (or dips) at half-quantized values of the measurement outputs. We discuss in detail the case of zero overlap between initial and final states demonstrating anomalously big average outputs and sudden jump in time-integrated output. We present and discuss the numerical evaluation of the probability distribution aiming at extending the analytical results and describing a realistic experimental situation of a qubit in the regime of resonant fluorescence.
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In-flight alignment using H ∞ filter for strapdown INS on aircraft.
Pei, Fu-Jun; Liu, Xuan; Zhu, Li
2014-01-01
In-flight alignment is an effective way to improve the accuracy and speed of initial alignment for strapdown inertial navigation system (INS). During the aircraft flight, strapdown INS alignment was disturbed by lineal and angular movements of the aircraft. To deal with the disturbances in dynamic initial alignment, a novel alignment method for SINS is investigated in this paper. In this method, an initial alignment error model of SINS in the inertial frame is established. The observability of the system is discussed by piece-wise constant system (PWCS) theory and observable degree is computed by the singular value decomposition (SVD) theory. It is demonstrated that the system is completely observable, and all the system state parameters can be estimated by optimal filter. Then a H ∞ filter was designed to resolve the uncertainty of measurement noise. The simulation results demonstrate that the proposed algorithm can reach a better accuracy under the dynamic disturbance condition.
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2007-08-14
Boeing Phantom Works' subscale Blended Wing Body technology demonstration aircraft began its initial flight tests from NASA's Dryden Flight Research Center at Edwards Air Force Base, Calif. in the summer of 2007. The 8.5 percent dynamically scaled unmanned aircraft, designated the X-48B by the Air Force, is designed to mimic the aerodynamic characteristics of a full-scale large cargo transport aircraft with the same blended wing body shape. The initial flight tests focused on evaluation of the X-48B's low-speed flight characteristics and handling qualities. About 25 flights were planned to gather data in these low-speed flight regimes. Based on the results of the initial flight test series, a second set of flight tests was planned to test the aircraft's low-noise and handling characteristics at transonic speeds.
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Code of Federal Regulations, 2010 CFR
2010-07-01
... Pollutants for Secondary Nonferrous Metals Processing Area Sources Standards, Compliance, and Monitoring... for structural integrity and fabric filter condition. You must record the results of the inspection...
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40 CFR 63.11960 - What are my initial and continuous compliance requirements for stripped resin?
Code of Federal Regulations, 2012 CFR
2012-07-01
...) Demonstration of initial compliance. You must demonstrate initial compliance for each resin stripper or for each group of resin strippers used to process the same resin type. (1) You must conduct an initial performance test for the resin stripper, measuring the concentration of vinyl chloride and total non-vinyl...
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40 CFR 63.11960 - What are my initial and continuous compliance requirements for stripped resin?
Code of Federal Regulations, 2013 CFR
2013-07-01
...) Demonstration of initial compliance. You must demonstrate initial compliance for each resin stripper or for each group of resin strippers used to process the same resin type. (1) You must conduct an initial performance test for the resin stripper, measuring the concentration of vinyl chloride and total non-vinyl...
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40 CFR 63.11960 - What are my initial and continuous compliance requirements for stripped resin?
Code of Federal Regulations, 2014 CFR
2014-07-01
...) Demonstration of initial compliance. You must demonstrate initial compliance for each resin stripper or for each group of resin strippers used to process the same resin type. (1) You must conduct an initial performance test for the resin stripper, measuring the concentration of vinyl chloride and total non-vinyl...
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Experimental demonstration of a two-phase population extinction hazard
Drake, John M.; Shapiro, Jeff; Griffen, Blaine D.
2011-01-01
Population extinction is a fundamental biological process with applications to ecology, epidemiology, immunology, conservation biology and genetics. Although a monotonic relationship between initial population size and mean extinction time is predicted by virtually all theoretical models, attempts at empirical demonstration have been equivocal. We suggest that this anomaly is best explained with reference to the transient properties of ensembles of populations. Specifically, we submit that under experimental conditions, many populations escape their initially vulnerable state to reach quasi-stationarity, where effects of initial conditions are erased. Thus, extinction of populations initialized far from quasi-stationarity may be exposed to a two-phase extinction hazard. An empirical prediction of this theory is that the fit Cox proportional hazards regression model for the observed survival time distribution of a group of populations will be shown to violate the proportional hazards assumption early in the experiment, but not at later times. We report results of two experiments with the cladoceran zooplankton Daphnia magna designed to exhibit this phenomenon. In one experiment, habitat size was also varied. Statistical analysis showed that in one of these experiments a transformation occurred so that very early in the experiment there existed a transient phase during which the extinction hazard was primarily owing to the initial population size, and that this was gradually replaced by a more stable quasi-stationary phase. In the second experiment, only habitat size unambiguously displayed an effect. Analysis of data pooled from both experiments suggests that the overall extinction time distribution in this system results from the mixture of extinctions during the initial rapid phase, during which the effects of initial population size can be considerable, and a longer quasi-stationary phase, during which only habitat size has an effect. These are the first results, to our knowledge, of a two-phase population extinction process. PMID:21429907
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FAST TRACK COMMUNICATION: Soliton solutions of the KP equation with V-shape initial waves
NASA Astrophysics Data System (ADS)
Kodama, Y.; Oikawa, M.; Tsuji, H.
2009-08-01
We consider the initial value problems of the Kadomtsev-Petviashvili (KP) equation for symmetric V-shape initial waves consisting of two semi-infinite line solitons with the same amplitude. Those are particularly important for studies of large amplitude waves such as tsunami in shallow water. Numerical simulations show that the solutions of the initial value problem approach asymptotically to certain exact solutions of the KP equation found recently in [1]. We then use a chord diagram to explain the asymptotic result. This provides an analytical method to study asymptotic behavior for the initial value problem of the KP equation. We also demonstrate a real experiment of shallow water waves which may represent the solution discussed in this communication.
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Thailand national programme of the Earth Resources Technology Satellite
NASA Technical Reports Server (NTRS)
Sabhasri, S. (Principal Investigator)
1976-01-01
The author has identified the following significant results. The study on locating hill tribe villages from LANDSAT imagery was successful and exceeded the initial expectations. Results of the study on land use and forest mapping using Skylab data demonstrated the capability and feasibility of large scale mapping with high accuracy.
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Code of Federal Regulations, 2011 CFR
2011-07-01
... initial startup or no later than 180 calendar days after the compliance date that is specified for your... compliance demonstrations that do not require performance tests upon initial startup or no later than 30...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... initial startup or no later than 180 calendar days after the compliance date that is specified for your... compliance demonstrations that do not require performance tests upon initial startup or no later than 30...
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NASA Technical Reports Server (NTRS)
Melcher, J. C.; Morehead, Robert L.
2014-01-01
The Project Morpheus liquid oxygen (LOX) / liquid methane rocket engines demonstrated acousticcoupled combustion instabilities during sea-level ground-based testing at the NASA Johnson Space Center (JSC) and Stennis Space Center (SSC). High-amplitude, 1T, 1R, 1T1R (and higher order) modes appear to be triggered by injector conditions. The instability occurred during the Morpheus-specific engine ignition/start sequence, and did demonstrate the capability to propagate into mainstage. However, the instability was never observed to initiate during mainstage, even at low power levels. The Morpheus main engine is a JSC-designed 5,000 lbf-thrust, 4:1 throttling, pressure-fed cryogenic engine using an impinging element injector design. Two different engine designs, named HD4 and HD5, and two different builds of the HD4 engine all demonstrated similar instability characteristics. Through the analysis of more than 200 hot fire tests on the Morpheus vehicle and SSC test stand, a relationship between ignition stability and injector/chamber pressure was developed. The instability has the distinct characteristic of initiating at high relative injection pressure drop (dP) at low chamber pressure (Pc); i.e., instabilities initiated at high dP/Pc at low Pc during the start sequence. The high dP/Pc during start results during the injector /chamber chill-in, and is enhanced by hydraulic flip in the injector orifice elements. Because of the fixed mixture ratio of the existing engine design (the main valves share a common actuator), it is not currently possible to determine if LOX or methane injector dP/Pc were individual contributors (i.e., LOX and methane dP/Pc typically trend in the same direction within a given test). The instability demonstrated initiation characteristic of starting at or shortly after methane injector chillin. Colder methane (e.g., sub-cooled) at the injector inlet prior to engine start was much more likely to result in an instability. A secondary effect of LOX sub-cooling was also possibly observed; greater LOX sub- cooling improved stability. Some tests demonstrated a low-amplitude 1L-1T instability prior to LOX injector chill-in. The Morpheus main engine also demonstrated chug instabilities during some engine shutdown sequences on the flight vehicle and SSC test stand. The chug instability was also infrequently observed during the startup sequence. The chug instabilities predictably initiated at low dP/Pc at low Pc. The chug instabilities were always self-limiting; startup chug instabilities terminated during throttle-up and shutdown chug instabilities decayed by shutdown termination.
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The status and initial results of the MAJORANA DEMONSTRATOR
NASA Astrophysics Data System (ADS)
Zhu, Xiaoyu; MAJORANA Collaboration
2017-01-01
The MAJORANA DEMONSTRATOR is an ultra-low background experiment searching for neutrinoless double-beta decay in 76Ge at the Sanford Underground Research Facility. The search for neutrinoless double-beta decay could determine the Dirac vs Majorana nature of neutrino mass and provide insight to the matter-antimatter asymmetry in the Universe. The DEMONSTRATOR is comprised of 44.8 kg (30 kg enriched in 76Ge) of high purity Ge detectors separated into two modules. Construction and commissioning of both modules completed in Summer 2016 and both modules are now acquiring physics data. In my talk, I will discuss the initial results of the first physics run utilizing both modules focusing primarily on the studies of the background and projections to a ton-scale experiment. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, the Particle Astrophysics Program of the National Science Foundation, and the Sanford Underground Research Facility. We acknowledge the support of the U.S. Department of Energy through the LANL/LDRD Program.
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Code of Federal Regulations, 2011 CFR
2011-07-01
..., Fuel Analyses, and Initial Compliance Requirements § 63.7530 How do I demonstrate initial compliance... this section, and Tables 5 and 7 to this subpart OR conducting initial fuel analyses to determine... in one of the liquid fuel subcategories that burn only fossil fuels and other gases and do not burn...
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Chapin, T.P.; Nimick, D.A.; Gammons, C.H.; Wanty, R.B.
2007-01-01
Recent work has demonstrated that many trace metals undergo dramatic diel (24-h) cycles in near neutral pH streams with metal concentrations reproducibly changing up to 500% during the diel period (Nimick et al., 2003). To examine diel zinc cycles in streams affected by acid rock drainage, we have developed a novel instrument, the Zn-DigiScan, to continuously monitor in situ zinc concentrations in near real-time. Initial results from a 3-day deployment at Fisher Creek, Montana have demonstrated the ability of the Zn-DigiScan to record diel Zn cycling at levels below 100 ??g/l. Longer deployments of this instrument could be used to examine the effects of episodic events such as rainstorms and snowmelt pulses on zinc loading in streams affected by acid rock drainage. ?? Springer Science+Business Media B.V. 2006.
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Orisme, Wilda; Li, Jian; Goldmann, Tobias; Bolch, Susan; Wolfrum, Uwe; Smith, W Clay
2010-03-01
Partitioning of cellular components is a critical mechanism by which cells can regulate their activity. In rod photoreceptors, light induces a large-scale translocation of arrestin from the inner segments to the outer segments. The purpose of this project is to elucidate the signaling pathway necessary to initiate arrestin translocation to the outer segments and the mechanism for arrestin translocation. Mouse retinal organotypic cultures and eyes from transgenic Xenopus tadpoles expressing a fusion of GFP and rod arrestin were treated with both activators and inhibitors of proteins in the phosphoinositide pathway. Confocal microscopy was used to image the effects of the pharmacological agents on arrestin translocation in rod photoreceptors. Retinas were also depleted of ATP using potassium cyanide to assess the requirement for ATP in arrestin translocation. In this study, we demonstrate that components of the G-protein-linked phospholipase C (PLC) pathway play a role in initiating arrestin translocation. Our results show that arrestin translocation can be stimulated by activators of PLC and protein kinase C (PKC), and by cholera toxin in the absence of light. Arrestin translocation to the outer segments is significantly reduced by inhibitors of PLC and PKC. Importantly, we find that treatment with potassium cyanide inhibits arrestin translocation in response to light. Collectively, our results suggest that arrestin translocation is initiated by a G-protein-coupled cascade through PLC and PKC signaling. Furthermore, our results demonstrate that at least the initiation of arrestin translocation requires energy input.
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Recurrent papillary craniopharyngioma with BRAF V600E mutation treated with dabrafenib: case report.
Himes, Benjamin T; Ruff, Michael W; Van Gompel, Jaimie J; Park, Sean S; Galanis, Evanthia; Kaufmann, Timothy J; Uhm, Joon H
2018-04-27
The authors present the case of a man with a papillary craniopharyngioma, first diagnosed at 47 years of age, who experienced multiple recurrences. Review of the pathologic specimen from his first resection demonstrated the BRAF V600E mutation. With his most recent recurrence following previous surgery and radiotherapy, at 52 years of age, the decision was made to initiate treatment with the BRAF V600E inhibitor dabrafenib. Imaging following initiation of dabrafenib demonstrated reduction in tumor size. He remained on dabrafenib therapy for approximately 1 year and continued to demonstrate a good clinical result. At that time the decision was made to discontinue dabrafenib therapy and follow up with serial imaging. After more than 1 year of follow-up since stopping dabrafenib, the patient has continued to do well with no radiographic evidence of tumor progression and continues to be monitored with frequent interval imaging.
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NASA Technical Reports Server (NTRS)
Higginbotham, Scott
2016-01-01
The National Aeronautics and Space Administration (NASA) recognizes the tremendous potential that CubeSats (very small satellites) have to inexpensively demonstrate advanced technologies, collect scientific data, and enhance student engagement in Science, Technology, Engineering, and Mathematics (STEM). The CubeSat Launch Initiative (CSLI) was created to provide launch opportunities for CubeSats developed by academic institutions, non-profit entities, and NASA centers. This presentation will provide an overview of the CSLI, its benefits, and its results.
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Framework for Shared Drinking Water Risk Assessment.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Lowry, Thomas Stephen; Tidwell, Vincent C.; Peplinski, William John
Central to protecting our nation's critical infrastructure is the development of methodologies for prioritizing action and supporting resource allocation decisions associated with risk-reduction initiatives. Toward this need a web-based risk assessment framework that promotes the anonymous sharing of results among water utilities is demonstrated. Anonymous sharing of results offers a number of potential advantages such as assistance in recognizing and correcting bias, identification of 'unknown, unknowns', self-assessment and benchmarking for the local utility, treatment of shared assets and/or threats across multiple utilities, and prioritization of actions beyond the scale of a single utility. The constructed framework was demonstrated for threemore » water utilities. Demonstration results were then compared to risk assessment results developed using a different risk assessment application by a different set of analysts.« less
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Enhanced Flight Termination System (EFTS): Flight Demonstration and Results
NASA Technical Reports Server (NTRS)
Tow, David; Arce, Dennis
2008-01-01
The Enhanced Flight Termination System (EFTS) program was initiated and propelled due to the inadvertent terminations of Global Hawk and the Strategic Target System and the NASA Inspector General's assessment letter and recommendations regarding the exploration of low-cost, lightweight space COMSEC for FTS. Additionally, the standard analog and high alphabet systems most commonly used in FTS are secure, but not encrypted. A study group was initiated to select and document a robust, affordable, reliable technology that provides encrypted FTS capability. A flight demonstration was conducted to gain experience using EFTS in an operational environment, provide confidence in the use of the EFTS components, integrate EFTS into an existing range infrastructure to demonstrate the scalability of system components, to provide a command controller that generated the EFTS waveform using an existing range infrastructure, and to provide a report documenting the results of the demonstration. The primary goal of the demonstration was to obtain operational experience with EFTS. Areas of operational experience include: mission planning, pre-flight configuration and testing, mission monitoring and recording, vehicle termination, developing mission procedures. and post mission data reduction and other post mission activities. An Advanced Medium-Range Air-to-Air Missile (AMRAAM) was selected to support the EFTS demonstration due to interest in future use of EFTS by the AMRAAM program, familiarity of EFTS by range personnel, and the availability of existing operational environment to support EFTS testing with available program funding. For demonstration purposes, the AMRAAM was successfully terminated using an EFTS receiver and successfully demonstrating EFTS. The EFTS monitoring software with spectrum analyzer and digital graphical display of aircraft, missile, and target were also demonstrated.
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Stochastic switching of TiO2-based memristive devices with identical initial memory states
2014-01-01
In this work, we show that identical TiO2-based memristive devices that possess the same initial resistive states are only phenomenologically similar as their internal structures may vary significantly, which could render quite dissimilar switching dynamics. We experimentally demonstrated that the resistive switching of practical devices with similar initial states could occur at different programming stimuli cycles. We argue that similar memory states can be transcribed via numerous distinct active core states through the dissimilar reduced TiO2-x filamentary distributions. Our hypothesis was finally verified via simulated results of the memory state evolution, by taking into account dissimilar initial filamentary distribution. PMID:24994953
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Initiation of rotors by fast propagation regions in excitable media: A theoretical study
NASA Astrophysics Data System (ADS)
Gao, Xiang; Krekhov, Alexei; Zykov, Vladimir; Bodenschatz, Eberhard
2018-02-01
We study the effect of geometry of a fast propagation region (FPR) in an excitable medium on the rotor initiation using a generic two-dimensional reaction-diffusion model. We find that, while the flat boundary of a rectangularly shaped FPR may block the propagation of the excitation wave, a large local curvature at the rounded corners of the FPR would prevent the blockage and thus initiate a rotor. Our simulations demonstrate that the prerequisites for the rotor initiation are the degree of the heterogeneity, its shape and size. These results may explain the incidence of arrhythmias by local heterogeneities induced, for example, by a cardiac tissue remodeling.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-05
... Information Collection: Transformation Initiative Rent Reform Demonstration Small Grants AGENCY: Office of... information: Title of Proposal: Notice of Funding Availability for the Transformation Initiative Rent Reform...-96011. Members of the affected public: Institutions of higher education accredited by a national or...
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Initial Checkout Results of the Compact Infrared Camera (circ) for Earth Observation
NASA Astrophysics Data System (ADS)
Kato, E.; Katayama, H.; Sakai, M.; Nakajima, Y.; Kimura, T.; Nakau, K.; Tonooka, H.
2015-04-01
Compact Infrared Camera (CIRC) is a technology-demonstration instrument equipped with an uncooled infrared array detector (microbolometer) for space application. CIRC is the first microbolometer sensor without a calibration function in orbit, like a shutter system or an onboard blackbody. The main objective of the CIRC is to detect wildfires, which are major and chronic disasters affecting various countries of Southeast Asia, particularly considering the effects of global warming and climate change. The CIRC achieves a small size (approximately 200 mm), light mass (approximately 3 kg), and low electrical power consumption (<20 W) by employing athermal optics and a shutterless system. The CIRC can be consequently mounted on multiple satellites to enable highfrequency observation. Installation of CIRCs on the ALOS-2 and on the JEM/CALET is expected to increase observation frequency. We present the initial check-out results of the CIRC onboard ALOS-2. Since the initial check-out phase (July 4-14, 2014), the CIRC has acquired the images of Earth. CIRC was demonstrated to function according to its intended design. After the early calibration validation phase, which confirmed the temperature accuracy of observed data, CIRC data has been available to the public January 2015 onward. We also introduce a few observational results about wildfire, volcanoes, and heat-island.
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40 CFR 63.5722 - How do I use the performance test data to demonstrate initial compliance?
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 13 2014-07-01 2014-07-01 false How do I use the performance test data... Boat Manufacturing Demonstrating Compliance for Open Molding Operations Controlled by Add-on Control Devices § 63.5722 How do I use the performance test data to demonstrate initial compliance? Demonstrate...
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40 CFR 63.5722 - How do I use the performance test data to demonstrate initial compliance?
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 13 2013-07-01 2012-07-01 true How do I use the performance test data... Boat Manufacturing Demonstrating Compliance for Open Molding Operations Controlled by Add-on Control Devices § 63.5722 How do I use the performance test data to demonstrate initial compliance? Demonstrate...
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40 CFR 63.5722 - How do I use the performance test data to demonstrate initial compliance?
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 13 2012-07-01 2012-07-01 false How do I use the performance test data... Boat Manufacturing Demonstrating Compliance for Open Molding Operations Controlled by Add-on Control Devices § 63.5722 How do I use the performance test data to demonstrate initial compliance? Demonstrate...
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Plasma irregularities in the D-region ionosphere in association with sprite streamer initiation.
Qin, Jianqi; Pasko, Victor P; McHarg, Matthew G; Stenbaek-Nielsen, Hans C
2014-05-07
Sprites are spectacular optical emissions in the mesosphere induced by transient lightning electric fields above thunderstorms. Although the streamer nature of sprites has been generally accepted, how these filamentary plasmas are initiated remains a subject of active research. Here we present observational and modelling results showing solid evidence of pre-existing plasma irregularities in association with streamer initiation in the D-region ionosphere. The video observations show that before streamer initiation, kilometre-scale spatial structures descend rapidly with the overall diffuse emissions of the sprite halo, but slow down and stop to form the stationary glow in the vicinity of the streamer onset, from where streamers suddenly emerge. The modelling results reproduce the sub-millisecond halo dynamics and demonstrate that the descending halo structures are optical manifestations of the pre-existing plasma irregularities, which might have been produced by thunderstorm or meteor effects on the D-region ionosphere.
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Ethnic Differences in Family Factors Related to Early Drug Initiation*
CATALANO, RICHARD F.; MORRISON, DIANE M.; WELLS, ELIZABETH A.; GILLMORE, MARY R.; IRITANI, BONITA; HAWKINS, J. DAVID
2007-01-01
The literature on family predictors of substance use for the general population is reviewed and compared to findings for three specific ethnic groups: black, white and Asian-Americans. Rates of substance use initiation are examined in a sample of 919 urban 5th-grade students. Ethnic differences on measures of family predictors are examined and significant ethnic differences are found on several of these factors. Finally, separate regressions for black, white and Asian American youths of family factors on the variety of substances initiated examine ethnic similarities and differences in predictors. The results demonstrate significant differences by ethnicity in family management practices, involvement in family activity, sibling deviance, parental disapproval of children's drinking and family structure. The regression equations identified unique as well as common predictors of the variety of substances initiated by the end of 5th grade. Implications of the results are discussed. PMID:1285743
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Complete quantum control of a single quantum dot spin using ultrafast optical pulses.
Press, David; Ladd, Thaddeus D; Zhang, Bingyang; Yamamoto, Yoshihisa
2008-11-13
A basic requirement for quantum information processing systems is the ability to completely control the state of a single qubit. For qubits based on electron spin, a universal single-qubit gate is realized by a rotation of the spin by any angle about an arbitrary axis. Driven, coherent Rabi oscillations between two spin states can be used to demonstrate control of the rotation angle. Ramsey interference, produced by two coherent spin rotations separated by a variable time delay, demonstrates control over the axis of rotation. Full quantum control of an electron spin in a quantum dot has previously been demonstrated using resonant radio-frequency pulses that require many spin precession periods. However, optical manipulation of the spin allows quantum control on a picosecond or femtosecond timescale, permitting an arbitrary rotation to be completed within one spin precession period. Recent work in optical single-spin control has demonstrated the initialization of a spin state in a quantum dot, as well as the ultrafast manipulation of coherence in a largely unpolarized single-spin state. Here we demonstrate complete coherent control over an initialized electron spin state in a quantum dot using picosecond optical pulses. First we vary the intensity of a single optical pulse to observe over six Rabi oscillations between the two spin states; then we apply two sequential pulses to observe high-contrast Ramsey interference. Such a two-pulse sequence realizes an arbitrary single-qubit gate completed on a picosecond timescale. Along with the spin initialization and final projective measurement of the spin state, these results demonstrate a complete set of all-optical single-qubit operations.
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Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 13 2010-07-01 2010-07-01 false How do I demonstrate initial... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS... Hazardous Air Pollutants for Stationary Reciprocating Internal Combustion Engines Testing and Initial...
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Demonstration of Unmanned Aircraft Systems Use for Traffic Incident Management (UAS-TIM)
DOT National Transportation Integrated Search
2017-12-01
Previous investigations into technologies that can improve incident response, monitoring, and clearance resulted in the potential application of Unmanned Aerial System (UAS) for use in Traffic Incident Management (TIM). An initial investigation of UA...
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Kinzey, B. R.; Myer, M. A.
2009-08-01
On the I-35W Bridge in Minneapolis, Minnesota, the GATEWAY program conducted a two-phase demonstration of LED roadway lighting on the main span, which is one of the country's oldest continuously operated exterior LED lighting installations. The Phase I report provides an overview of initial project results including lighting performance, economic performance, and potential energy savings.
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Forestry timber typing. Tanana demonstration project, Alaska ASVT. [Alaska
NASA Technical Reports Server (NTRS)
Morrissey, L. A.; Ambrosia, V. G.
1982-01-01
The feasibility of using LANDSAT digital data in conjunction with topographic data to delineate commercial forests by stand size and crown closure in the Tanana River basin of Alaska was tested. A modified clustering approach using two LANDSAT dates to generate an initial forest type classification was then refined with topographic data. To further demonstrate the ability of remotely sensed data in a fire protection planning framework, the timber type data were subsequently integrated with terrain information to generate a fire hazard map of the study area. This map provides valuable assistance in initial attack planning, determining equipment accessibility, and fire growth modeling. The resulting data sets were incorporated into the Alaska Department of Natural Resources geographic information system for subsequent utilization.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Clark, Jared Matthew; Daum, Keith Alvin; Kalival, J. H.
2003-01-01
This initial study evaluates the use of ion mobility spectrometry (IMS) as a rapid test procedure for potential detection of adulterated perfumes and speciation of plant life. Sample types measured consist of five genuine perfumes, two species of sagebrush, and four species of flowers. Each sample type is treated as a separate classification problem. It is shown that discrimination using principal component analysis with K-nearest neighbors can distinguish one class from another. Discriminatory models generated using principal component regressions are not as effective. Results from this examination are encouraging and represent an initial phase demonstrating that perfumes and plants possessmore » characteristic chemical signatures that can be used for reliable identification.« less
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Waste inspection tomography (WIT)
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bernardi, R.T.
1996-12-31
WIT is a self-sufficient mobile semitrailer for nondestructive evaluation and nondestructive assay of nuclear waste drums using x-ray and gamma-ray tomography. The recently completed Phase I included the design, fabrication, and initial testing of all WIT subsystems installed on-board the trailer. Initial test results include 2 MeV digital radiography, computed tomography, Anger camera imaging, single photon emission computed tomography, gamma-ray spectroscopy, collimated gamma scanning, and active and passive computed tomography using a 1.4 mCi source of {sup 166}Ho. These techniques were initially demonstrated on a 55-gallon phantom drum with 3 simulated waste matrices of combustibles, heterogeneous metals, and cement usingmore » check sources of gamma active isotopes such as {sup 137}Cs and {sup 133}Ba with 9-250 {mu}Ci activities. Waste matrix identification, isotopic identification, and attenuation-corrected gamma activity determination were demonstrated nondestructively and noninvasively in Phase I. Currently ongoing Phase II involves DOE site field test demonstrations at LLNL, RFETS, and INEL with real nuclear waste drums. Current WIT experience includes 55 gallon drums of cement, graphite, sludge, glass, metals, and combustibles. Thus far WIT has inspected drums with 0-20 gms of {sup 239}Pu.« less
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Matos, Sergio; Kapadia, Smiti; Islam, Nadia; Cusack, Arthur; Kwong, Sylvia; Trinh-Shevrin, Chau
2012-01-01
Objectives. Despite the importance of community health workers (CHWs) in strategies to reduce health disparities and the call to enhance their roles in research, little information exists on how to prepare CHWs involved in community–academic initiatives (CAIs). Therefore, the New York University Prevention Research Center piloted a CAI–CHW training program. Methods. We applied a core competency framework to an existing CHW curriculum and bolstered the curriculum to include research-specific sessions. We employed diverse training methods, guided by adult learning principles and popular education philosophy. Evaluation instruments assessed changes related to confidence, intention to use learned skills, usefulness of sessions, and satisfaction with the training. Results. Results demonstrated that a core competency–based training can successfully affect CHWs’ perceived confidence and intentions to apply learned content, and can provide a larger social justice context of their role and work. Conclusions. This program demonstrates that a core competency–based framework coupled with CAI-research–specific skill sessions (1) provides skills that CAI–CHWs intend to use, (2) builds confidence, and (3) provides participants with a more contextualized view of client needs and CHW roles. PMID:22594730
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Carroll-Scott, Amy; Toy, Peggy; Wyn, Roberta; Zane, Jazmin I; Wallace, Steven P
2012-07-01
In an era of community-based participatory research and increased expectations for evidence-based practice, we evaluated an initiative designed to increase community-based organizations' data and research capacity through a 3-day train-the-trainer course on community health assessments. We employed a mixed method pre-post course evaluation design. Various data sources collected from 171 participants captured individual and organizational characteristics and pre-post course self-efficacy on 19 core skills, as well as behavior change 1 year later among a subsample of participants. Before the course, participants reported limited previous experience with data and low self-efficacy in basic research skills. Immediately after the course, participants demonstrated statistically significant increases in data and research self-efficacy. The subsample reported application of community assessment skills to their work and increased use of data 1 year later. Results suggest that an intensive, short-term training program can achieve large immediate gains in data and research self-efficacy in community-based organization staff. In addition, they demonstrate initial evidence of longer-term behavior change related to use of data and research skills to support their community work.
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Burkhalter, Rebecca J.; Westfall, Suzanne D.; Liu, Yueying; Stack, M. Sharon
2015-01-01
During tumor progression, epithelial ovarian cancer (EOC) cells undergo epithelial-to-mesenchymal transition (EMT), which influences metastatic success. Mutation-dependent activation of Wnt/β-catenin signaling has been implicated in gain of mesenchymal phenotype and loss of differentiation in several solid tumors; however, similar mutations are rare in most EOC histotypes. Nevertheless, evidence for activated Wnt/β-catenin signaling in EOC has been reported, and immunohistochemical analysis of human EOC tumors demonstrates nuclear staining in all histotypes. This study addresses the hypothesis that the bioactive lipid lysophosphatidic acid (LPA), prevalent in the EOC microenvironment, functions to regulate EMT in EOC. Our results demonstrate that LPA induces loss of junctional β-catenin, stimulates clustering of β1 integrins, and enhances the conformationally active population of surface β1 integrins. Furthermore, LPA treatment initiates nuclear translocation of β-catenin and transcriptional activation of Wnt/β-catenin target genes resulting in gain of mesenchymal marker expression. Together these data suggest that LPA initiates EMT in ovarian tumors through β1-integrin-dependent activation of Wnt/β-catenin signaling, providing a novel mechanism for mutation-independent activation of this pathway in EOC progression. PMID:26175151
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Wong, M S; Cheng, J C Y; Lo, K H
2005-04-01
The treatment effectiveness of the CAD/CAM method and the manual method in managing adolescent idiopathic scoliosis (AIS) was compared. Forty subjects were recruited with twenty subjects for each method. The clinical parameters namely Cobb's angle and apical vertebral rotation were evaluated at the pre-brace and the immediate in-brace visits. The results demonstrated that orthotic treatments rendered by the CAD/CAM method and the conventional manual method were effective in providing initial control of Cobb's angle. Significant decreases (p < 0.05) were found between the pre-brace and immediate in-brace visits for both methods. The mean reductions of Cobb's angle were 12.8 degrees (41.9%) for the CAD/CAM method and 9.8 degrees (32.1%) for the manual method. An initial control of the apical vertebral rotation was not shown in this study. In the comparison between the CAD/CAM method and the manual method, no significant difference was found in the control of Cobb's angle and apical vertebral rotation. The current study demonstrated that the CAD/CAM method can provide similar result in the initial stage of treatment as compared with the manual method.
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Redundant imprinting of information in nonideal environments: Objective reality via a noisy channel
NASA Astrophysics Data System (ADS)
Zwolak, Michael; Quan, H. T.; Zurek, Wojciech H.
2010-06-01
Quantum Darwinism provides an information-theoretic framework for the emergence of the objective, classical world from the quantum substrate. The key to this emergence is the proliferation of redundant information throughout the environment where observers can then intercept it. We study this process for a purely decohering interaction when the environment, E, is in a nonideal (e.g., mixed) initial state. In the case of good decoherence, that is, after the pointer states have been unambiguously selected, the mutual information between the system, S, and an environment fragment, F, is given solely by F’s entropy increase. This demonstrates that the environment’s capacity for recording the state of S is directly related to its ability to increase its entropy. Environments that remain nearly invariant under the interaction with S, either because they have a large initial entropy or a misaligned initial state, therefore have a diminished ability to acquire information. To elucidate the concept of good decoherence, we show that, when decoherence is not complete, the deviation of the mutual information from F’s entropy change is quantified by the quantum discord, i.e., the excess mutual information between S and F is information regarding the initial coherence between pointer states of S. In addition to illustrating these results with a single-qubit system interacting with a multiqubit environment, we find scaling relations for the redundancy of information acquired by the environment that display a universal behavior independent of the initial state of S. Our results demonstrate that Quantum Darwinism is robust with respect to nonideal initial states of the environment: the environment almost always acquires redundant information about the system but its rate of acquisition can be reduced.
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Pearse, Bronwyn Louise; Rickard, Claire M; Keogh, Samantha; Lin Fung, Yoke
2018-03-09
Bleeding management in cardiac surgery is challenging. Many guidelines exist to support bleeding management; however, literature demonstrates wide variation in practice. In 2012, a quality initiative was undertaken at The Prince Charles Hospital, Australia to improve bleeding management for cardiac surgery patients. The implementation of the quality initiative resulted in significant reductions in the incidence of blood transfusion, re-exploration for bleeding; superficial leg and chest wound infections; length of hospital stay, and cost. Given the success of the initiative, we sought to answer the question; "How and why was the process of implementing a bleeding management quality initiative in the cardiac surgery unit successful, and sustainable?" A retrospective explanatory case study design was chosen to explore the quality initiative. Analysis of the evidence was reviewed through phases of the 'Knowledgeto Action' planned change model. Data was derived from: (1) document analysis, (2) direct observation of the local environment, (3) clinical narratives from interviews, and analysed with a triangulation approach. The study period extended from 10/2011 to 6/2013. Results demonstrated the complexity of changing practice, as well as the significant amount of dedicated time and effort required to support individual, department and system wide change. Results suggest that while many clinicians were aware of the potential to apply improved practice, numerous barriers and challenges needed to be overcome to implement change across multiple disciplines and departments. The key successful components of the QI were revealed through the case study analysis as: (1) an appropriately skilled project manager to facilitate the implementation process; (2) tools to support changes in workflow and decision making including a bleeding management treatment algorithm with POCCTs; (3) strong clinical leadership from the multidisciplinary team and; (4) the evolution of the project manager position into a perpetual clinical position to support sustainability. Copyright © 2018 Australian College of Critical Care Nurses Ltd. All rights reserved.
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Code of Federal Regulations, 2012 CFR
2012-07-01
... reconstituted wood product press or board cooler. 63.2267 Section 63.2267 Protection of Environment... Pollutants: Plywood and Composite Wood Products Initial Compliance Requirements § 63.2267 Initial compliance demonstration for a reconstituted wood product press or board cooler. If you operate a reconstituted wood...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... reconstituted wood product press or board cooler. 63.2267 Section 63.2267 Protection of Environment... Pollutants: Plywood and Composite Wood Products Initial Compliance Requirements § 63.2267 Initial compliance demonstration for a reconstituted wood product press or board cooler. If you operate a reconstituted wood...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... reconstituted wood product press or board cooler. 63.2267 Section 63.2267 Protection of Environment... Pollutants: Plywood and Composite Wood Products Initial Compliance Requirements § 63.2267 Initial compliance demonstration for a reconstituted wood product press or board cooler. If you operate a reconstituted wood...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... Hazardous Air Pollutants: Mercury Emissions From Mercury Cell Chlor-Alkali Plants Initial Compliance... standards? (a) For each mercury cell chlor-alkali production facility, you have demonstrated initial compliance with the applicable emission limit for by-product hydrogen streams and end box ventilation system...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... Hazardous Air Pollutants: Mercury Emissions From Mercury Cell Chlor-Alkali Plants Initial Compliance... standards? (a) For each mercury cell chlor-alkali production facility, you have demonstrated initial compliance with the applicable emission limit for by-product hydrogen streams and end box ventilation system...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... Hazardous Air Pollutants: Mercury Emissions From Mercury Cell Chlor-Alkali Plants Initial Compliance... standards? (a) For each mercury cell chlor-alkali production facility, you have demonstrated initial compliance with the applicable emission limit for by-product hydrogen streams and end box ventilation system...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... Hazardous Air Pollutants: Mercury Emissions From Mercury Cell Chlor-Alkali Plants Initial Compliance... standards? (a) For each mercury cell chlor-alkali production facility, you have demonstrated initial compliance with the applicable emission limit for by-product hydrogen streams and end box ventilation system...
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Code of Federal Regulations, 2010 CFR
2010-07-01
...). (2) You choose the continuous cell room monitoring program option, you certify in your Notification... Hazardous Air Pollutants: Mercury Emissions From Mercury Cell Chlor-Alkali Plants Initial Compliance... standards? (a) For each mercury cell chlor-alkali production facility, you have demonstrated initial...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... with the emission limits for tire production affected sources? 63.5996 Section 63.5996 Protection of... Pollutants: Rubber Tire Manufacturing Testing and Initial Compliance Requirements for Tire Production Affected Sources § 63.5996 How do I demonstrate initial compliance with the emission limits for tire...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... compliance with the emission limitations, fuel specifications and work practice standards? 63.7530 Section 63... Institutional Boilers and Process Heaters Testing, Fuel Analyses, and Initial Compliance Requirements § 63.7530 How do I demonstrate initial compliance with the emission limitations, fuel specifications and work...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... compliance with the emission limitations, fuel specifications and work practice standards? 63.7530 Section 63... Institutional Boilers and Process Heaters Testing, Fuel Analyses, and Initial Compliance Requirements § 63.7530 How do I demonstrate initial compliance with the emission limitations, fuel specifications and work...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... reconstituted wood product press or board cooler. 63.2267 Section 63.2267 Protection of Environment... and Composite Wood Products Initial Compliance Requirements § 63.2267 Initial compliance demonstration for a reconstituted wood product press or board cooler. If you operate a reconstituted wood product...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... reconstituted wood product press or board cooler. 63.2267 Section 63.2267 Protection of Environment... and Composite Wood Products Initial Compliance Requirements § 63.2267 Initial compliance demonstration for a reconstituted wood product press or board cooler. If you operate a reconstituted wood product...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... compliance demonstration or performance test? 63.5991 Section 63.5991 Protection of Environment ENVIRONMENTAL... POLLUTANTS FOR SOURCE CATEGORIES National Emissions Standards for Hazardous Air Pollutants: Rubber Tire... initial compliance demonstration or performance test? (a) If you have a new or reconstructed affected...
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Results of the Clarus regional demonstrations : evaluation of four decision support tools.
DOT National Transportation Integrated Search
2012-01-01
The Clarus Initiative is a research effort of the U.S. Department of Transportation Intelligent Transportation Systems (ITS) Joint Program Offi ce and the Federal Highway Administrations (FHWA) Road Weather Management Program (RWMP) to develop and...
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Field demonstration of new bridge approach slab designs and performance.
DOT National Transportation Integrated Search
2014-06-01
The Louisiana Department of Transportation and Development (DOTD) has initiated a major effort to minimize the bridge end bump problem associated : with differential settlement. As a result, a new design for the approach slab was proposed, which requ...
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NASA Astrophysics Data System (ADS)
Sohn, G.; Jung, J.; Jwa, Y.; Armenakis, C.
2013-05-01
This paper presents a sequential rooftop modelling method to refine initial rooftop models derived from airborne LiDAR data by integrating it with linear cues retrieved from single imagery. A cue integration between two datasets is facilitated by creating new topological features connecting between the initial model and image lines, with which new model hypotheses (variances to the initial model) are produced. We adopt Minimum Description Length (MDL) principle for competing the model candidates and selecting the optimal model by considering the balanced trade-off between the model closeness and the model complexity. Our preliminary results, combined with the Vaihingen data provided by ISPRS WGIII/4 demonstrate the image-driven modelling cues can compensate the limitations posed by LiDAR data in rooftop modelling.
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Hildebrand, Deana A; McCarthy, Pam; Tipton, Debi; Merriman, Connie; Schrank, Melody; Newport, Melinda
2014-01-01
To determine whether integrating influence strategies (reciprocation, consistency, consensus, feeling liked, authority, and scarcity) throughout Chickasaw Nation Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) clinics (1) changed participants' perception of the WIC experience and (2) affected breastfeeding initiation rates. Two-part, quasi-experimental design. Four WIC clinics. Parents and caregivers of children birth to 3 years. Behavior change intervention based on Social Cognitive Theory using Caildini's Principles of Influence. Traditional-model groups (control) received services prior to the intervention; influence-model groups (experimental) received services after initiation of the intervention. The preliminary demonstration project surveyed 2 groups to measure changes in their perceptions of the WIC environment. Secondary data analysis measured changes in breastfeeding initiation in 2 groups of postpartum women. Frequency analysis, independent sample t tests, chi-square for independence, step-wise logistic regression. The demonstration project resulted in 5 improved influence measures (P < .02), aligning with the influence principle of "feeling liked." The model had a small effect (φ = 0.10) in distinguishing breastfeeding initiation; women in the influence model were 1.5 times more likely (95% CI, 1.19-1.86; P < .05) to initiate breastfeeding compared with women in the traditional model, controlling for parity, mother's age, and race. Consistent with Social Cognitive Theory, changing the WIC environment by integrating influence principles may positively affect women's infant feeding decisions and behaviors, specifically breastfeeding initiation rates. Copyright © 2014 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.
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Hanna-Bull, Debbie
2016-01-01
The setting for this quality improvement initiative designed to reduce the prevalence of facility-acquired heel pressure ulcers was a regional, acute-care, 490-bed facility in Ontario, Canada, responsible for dialysis, vascular, and orthopedic surgery. An interdisciplinary skin and wound care team designed an evidence-based quality improvement initiative based on a systematic literature review and standardization of heel offloading methods. The prevalence of heel pressure ulcers was measured at baseline (immediately prior to implementation of initiative) and at 1 and 4 years following implementation. The prevalence of facility-acquired heel pressure ulcers was 5.8% when measured before project implementation. It was 4.2% at 1 year following implementation and 1.6% when measured at the end of the 4-year initiative. Outcomes demonstrate that the initiative resulted in a continuous and sustained reduction in facility-acquired heel pressure ulcer incidence over a 4-year period.
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Exponential Sensitivity and its Cost in Quantum Physics
Gilyén, András; Kiss, Tamás; Jex, Igor
2016-01-01
State selective protocols, like entanglement purification, lead to an essentially non-linear quantum evolution, unusual in naturally occurring quantum processes. Sensitivity to initial states in quantum systems, stemming from such non-linear dynamics, is a promising perspective for applications. Here we demonstrate that chaotic behaviour is a rather generic feature in state selective protocols: exponential sensitivity can exist for all initial states in an experimentally realisable optical scheme. Moreover, any complex rational polynomial map, including the example of the Mandelbrot set, can be directly realised. In state selective protocols, one needs an ensemble of initial states, the size of which decreases with each iteration. We prove that exponential sensitivity to initial states in any quantum system has to be related to downsizing the initial ensemble also exponentially. Our results show that magnifying initial differences of quantum states (a Schrödinger microscope) is possible; however, there is a strict bound on the number of copies needed. PMID:26861076
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Exponential Sensitivity and its Cost in Quantum Physics.
Gilyén, András; Kiss, Tamás; Jex, Igor
2016-02-10
State selective protocols, like entanglement purification, lead to an essentially non-linear quantum evolution, unusual in naturally occurring quantum processes. Sensitivity to initial states in quantum systems, stemming from such non-linear dynamics, is a promising perspective for applications. Here we demonstrate that chaotic behaviour is a rather generic feature in state selective protocols: exponential sensitivity can exist for all initial states in an experimentally realisable optical scheme. Moreover, any complex rational polynomial map, including the example of the Mandelbrot set, can be directly realised. In state selective protocols, one needs an ensemble of initial states, the size of which decreases with each iteration. We prove that exponential sensitivity to initial states in any quantum system has to be related to downsizing the initial ensemble also exponentially. Our results show that magnifying initial differences of quantum states (a Schrödinger microscope) is possible; however, there is a strict bound on the number of copies needed.
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In-Flight Alignment Using H ∞ Filter for Strapdown INS on Aircraft
Pei, Fu-Jun; Liu, Xuan; Zhu, Li
2014-01-01
In-flight alignment is an effective way to improve the accuracy and speed of initial alignment for strapdown inertial navigation system (INS). During the aircraft flight, strapdown INS alignment was disturbed by lineal and angular movements of the aircraft. To deal with the disturbances in dynamic initial alignment, a novel alignment method for SINS is investigated in this paper. In this method, an initial alignment error model of SINS in the inertial frame is established. The observability of the system is discussed by piece-wise constant system (PWCS) theory and observable degree is computed by the singular value decomposition (SVD) theory. It is demonstrated that the system is completely observable, and all the system state parameters can be estimated by optimal filter. Then a H ∞ filter was designed to resolve the uncertainty of measurement noise. The simulation results demonstrate that the proposed algorithm can reach a better accuracy under the dynamic disturbance condition. PMID:24511300
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Ditta, Annie S; Storm, Benjamin C
2017-05-01
Four experiments examined participants' ability to remember their own ideas in a modified Alternative Uses Task. Participants were asked to generate uses for objects, and on half of the trials participants were then asked to think of more uses. Memory for the initial uses they generated was then tested via a cued-recall task. Results demonstrated that participants forgot their initial uses as a consequence of thinking of new uses (referred to as the thinking-induced forgetting effect), and this effect persisted even when participants chose the subset of uses they thought were the most creative and to be remembered. The only scenario in which uses were protected from forgetting was when they were required to use their uses as hints for generating more ideas. Together, these findings demonstrate that one's own ideas are susceptible to forgetting when additional ideas must be generated, indicating that thinking is a modifier of memory despite one's motivation to preserve their ideas.
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Raghupathy, Shobana; Klein, Charles; Card, Josefina
2013-01-01
The purpose of this research was to conduct a preliminary evaluation of the Abstinence and Contraception Education Storehouse (ACES), a digital, classroom-based resource designed to supplement existing sex education curricula with highly interactive materials such as video clips, multimedia polls and quizzes, and audiovisual demonstrations. 335 students ages 14–19 were randomly assigned to an ACES–based (treatment) or a standard (control) sex education curriculum. Data were collected at the onset of the intervention and 3-months after the completion of the intervention. Preliminary results were highly encouraging, with ACES participants who were sexually initiated at baseline reporting at the 3-month follow-up significant reductions in the number of times they had sex in the past four weeks. Both sexually initiated and non-sexually initiated youth who experienced the ACES curriculum also demonstrated greater intent to abstain from the sex during the follow-up period than those in the control group. PMID:24078799
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Effect of solution treatment on the fatigue behavior of an as-forged Mg-Zn-Y-Zr alloy
NASA Astrophysics Data System (ADS)
Wang, S. D.; Xu, D. K.; Wang, B. J.; Han, E. H.; Dong, C.
2016-04-01
Through investigating and comparing the fatigue behavior of an as-forged Mg-6.7Zn-1.3Y-0.6Zr (wt.%) alloy before and after solid solution treatment (T4) in laboratory air, the effect of T4 treatment on fatigue crack initiation was disclosed. S-N curves illustrated that the fatigue strength of as-forged samples was 110 MPa, whereas the fatigue strength of T4 samples was only 80 MPa. Observations to fracture surfaces demonstrated that for as-forged samples, fatigue crack initiation sites were covered with a layer of oxide film. However, due to the coarse grain structure and the dissolution of MgZn2 precipitates, the activation and accumulation of {10-12} twins in T4 samples were much easier, resulting in the preferential fatigue crack initiation at cracked twin boundaries (TBs). Surface characterization demonstrated that TB cracking was mainly ascribed to the incompatible plastic deformation in the twinned area and nearby α-Mg matrix.
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Odegard, Timothy N; Koen, Joshua D
2007-11-01
Both positive and negative testing effects have been demonstrated with a variety of materials and paradigms (Roediger & Karpicke, 2006b). The present series of experiments replicate and extend the research of Roediger and Marsh (2005) with the addition of a "none-of-the-above" response option. Participants (n=32 in both experiments) read a set of passages, took an initial multiple-choice test, completed a filler task, and then completed a final cued-recall test (Experiment 1) or multiple-choice test (Experiment 2). Questions were manipulated on the initial multiple-choice test by adding a "none-of-the-above" response alternative (choice "E") that was incorrect ("E" Incorrect) or correct ("E" Correct). The results from both experiments demonstrated that the positive testing effect was negated when the "none-of-the-above" alternative was the correct response on the initial multiple-choice test, but was still present when the "none-of-the-above" alternative was an incorrect response.
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Raghupathy, Shobana; Klein, Charles; Card, Josefina
2013-01-01
The purpose of this research was to conduct a preliminary evaluation of the Abstinence and Contraception Education Storehouse (ACES), a digital, classroom-based resource designed to supplement existing sex education curricula with highly interactive materials such as video clips, multimedia polls and quizzes, and audiovisual demonstrations. 335 students ages 14-19 were randomly assigned to an ACES-based (treatment) or a standard (control) sex education curriculum. Data were collected at the onset of the intervention and 3-months after the completion of the intervention. Preliminary results were highly encouraging, with ACES participants who were sexually initiated at baseline reporting at the 3-month follow-up significant reductions in the number of times they had sex in the past four weeks. Both sexually initiated and non-sexually initiated youth who experienced the ACES curriculum also demonstrated greater intent to abstain from the sex during the follow-up period than those in the control group.
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Efficient Jacobi-Gauss collocation method for solving initial value problems of Bratu type
NASA Astrophysics Data System (ADS)
Doha, E. H.; Bhrawy, A. H.; Baleanu, D.; Hafez, R. M.
2013-09-01
In this paper, we propose the shifted Jacobi-Gauss collocation spectral method for solving initial value problems of Bratu type, which is widely applicable in fuel ignition of the combustion theory and heat transfer. The spatial approximation is based on shifted Jacobi polynomials J {/n (α,β)}( x) with α, β ∈ (-1, ∞), x ∈ [0, 1] and n the polynomial degree. The shifted Jacobi-Gauss points are used as collocation nodes. Illustrative examples have been discussed to demonstrate the validity and applicability of the proposed technique. Comparing the numerical results of the proposed method with some well-known results show that the method is efficient and gives excellent numerical results.
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Long-Term Maintenance of Pharmacists' Inhaler Technique Demonstration Skills
Armour, Carol L; Reddel, Helen K; Bosnic-Anticevich, Sinthia Z
2009-01-01
Objective To assess the effectiveness of a single educational intervention, followed by patient education training, in pharmacists retaining their inhaler technique skills. Methods A convenience sample of 31 pharmacists attended an educational workshop and their inhaler techniques were assessed. Those randomly assigned to the active group were trained to assess and teach correct Turbuhaler and Diskus inhaler techniques to patients and provided with patient education tools to use in their pharmacies during a 6-month study. Control pharmacists delivered standard care. All pharmacists were reassessed 2 years after initial training. Results Thirty-one pharmacists participated in the study. At the initial assessment, few pharmacists demonstrated correct technique (Turbuhaler:13%, Diskus:6%). All pharmacists in the active group demonstrated correct technique following training. Two years later, pharmacists in the active group demonstrated significantly better inhaler technique than pharmacists in the control group (p < 0.05) for Turbuhaler and Diskus (83% vs.11%; 75% vs.11%, respectively). Conclusion Providing community pharmacists with effective patient education tools and encouraging their involvement in educating patients may contribute to pharmacists maintaining their competence in correct inhaler technique long-term. PMID:19513170
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Q-Sync Motors in Commercial Refrigeration. Preliminary Test Results and Projected Benefits
DOE Office of Scientific and Technical Information (OSTI.GOV)
Fricke, Brian A.; Becker, Bryan R.
This report provides background information on various fractional-horsepower electric motor technologies, summarizes initial data from a DOE-sponsored Q-Sync motor demonstration project, and extrapolates that data to project the potential economic and environmental benefits resulting from upgrading the current installed base of 9–12 W evaporator fan motors to Q-Sync motors.
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Code of Federal Regulations, 2010 CFR
2010-07-01
... with the emission limits for tire cord production affected sources? 63.5999 Section 63.5999 Protection... Pollutants: Rubber Tire Manufacturing Testing and Initial Compliance Requirements for Tire Cord Production Affected Sources § 63.5999 How do I demonstrate initial compliance with the emission limits for tire cord...
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Atlanta congestion reduction demonstration. National evaluation : cost benefit analysis test plan.
DOT National Transportation Integrated Search
2001-01-01
Initiatives to evaluate the impact of Advanced Traveler Information Services (ATIS) over the last ten years have returned what appears to be contradictory results with respect to the time savings of ATIS users: large perceived time savings reported b...
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Centaur operations at the space station: Cost and transportation analysis
NASA Technical Reports Server (NTRS)
1988-01-01
A study was conducted to expand on the results of an initial study entitled Centaur Operations at the Space Station. The previous study developed technology demonstration missions (TDMs) that utilized the Centaur G-prime upper stage to advance OTV technologies required for accomodations and operations at the Space Station. An initial evaluation was performed of the cost to NASA for TDM implementation. Due to the potential for commercial communication satellite operation utilizing the TDM hardware, an evaluation of the Centaur's transportation potential was also performed.
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Lang, Russell; Regester, April; Mulloy, Austin; Rispoli, Mandy; Botout, Amanda
2011-01-01
We evaluated a behavioral intervention for a 9-year-old girl with selective mutism. The intervention consisted of role play and video self-modeling. The frequency of spoken initiations, responses to questions, and communication breakdowns was measured during three social situations (i.e., ordering in a restaurant, meeting new adults, and playing with new children) and in three community settings. Results demonstrated increases in spoken initiations and responses and decreases in communication breakdowns across all situations and settings. PMID:21941394
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Lang, Russell; Regester, April; Mulloy, Austin; Rispoli, Mandy; Botout, Amanda
2011-01-01
We evaluated a behavioral intervention for a 9-year-old girl with selective mutism. The intervention consisted of role play and video self-modeling. The frequency of spoken initiations, responses to questions, and communication breakdowns was measured during three social situations (i.e., ordering in a restaurant, meeting new adults, and playing with new children) and in three community settings. Results demonstrated increases in spoken initiations and responses and decreases in communication breakdowns across all situations and settings.
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Parekh, Parth; Boggs, Jody P; Silverberg, Marc; Marik, Paul
2013-11-14
We present a case of a 46-year-old man with a history significant only for hypertension and depression that presented with a new onset seizure resulting from a right parietal lobe mass. Further evaluation determined the parietal mass to be central nervous system toxoplasmosis, which was the initial presentation of his underlying HIV/AIDS. This case provided a diagnostic challenge and demonstrates the importance of a thorough evaluation as it pertains to a newly diagnosed brain lesion.
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Initial Field Deployment Results of Green PCB Removal from Sediment Systems (GPRSS)
NASA Technical Reports Server (NTRS)
DeVor, Robert William
2014-01-01
The goal of this task order was to complete optimization and development of the Green PCB Remediation from Sediment Systems(GPRSSs) technology, culminating in the production of functioning demonstration test units which would be deployed at a suitable demonstration location. This location would be selected in conjunction with Toxicological & Ecological Associates who have entered into a SAA with NASA to partner with and further develop this technology. The GPRSSs technology was initially developed under ESC Task Order 83 with the purpose of providing a green remediation technology capable of in-situ removal and remediation of polychlorinated biphenyls (PCBs) from contaminated sediments. The core concept of the technology, a polymeric blanket capable of absorbing PCBs when in contact with contaminated sediments was then transitioned to Task Order 165 where the primary objective was to fully design and optimize a functioning test unit capable of testing the theoretical and laboratory scale concepts in a real world situation. Results from both task orders are included in this report for completeness, although Task Order 165 focused on the blanket design and the small scale field demonstration in which is currently still ongoing in Altavista, VA.
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Analysis of PCR Thermocycling by Rayleigh-Bénard Convection
NASA Astrophysics Data System (ADS)
Sharma, Ruchi; Ugaz, Victor
2004-03-01
In previous studies, we demonstrated a novel device employing the circulatory flow field established by Rayleigh-Bénard convection to perform amplification of a 295 base target region from a human genomic DNA template inside a 35 uL cylindrical cavity using the polymerase chain reaction (PCR) [Krishnan, Ugaz & Burns, Science, Vol. 298, 2002, p. 793]. This design eliminates the need for dynamic external temperature control required in conventional thermocyclers that repeatedly heat and cool static sample volumes to denaturation, annealing, and extension temperatures. In this paper, we extend these studies by demonstrating the design and operation of a multiwell convective flow device capable of achieving amplification of a 191 base pair fragment associated with membrane channel proteins M1 and M2 of the influenza-A virus in as little as 15 minutes with performance comparable to a conventional thermocycler. We also study the effect of initial template concentration and observe no degradation in performance over four orders of magnitude of initial template loading dilution, consistent with conventional thermocycler results. These results illustrate the ability of convective flow PCR systems to achieve performance equal to or exceeding conventional thermocycling hardware, and demonstrate their suitability for use in rapid biodetection assays.
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Denno, Donna M; Hoopes, Andrea J; Chandra-Mouli, Venkatraman
2015-01-01
Access to youth friendly health services is vital for ensuring sexual and reproductive health (SRH) and well-being of adolescents. This study is a descriptive review of the effectiveness of initiatives to improve adolescent access to and utilization of sexual and reproductive health services (SRHS) in low- and middle-income countries. We examined four SRHS intervention types: (1) facility based, (2) out-of-facility based, (3) interventions to reach marginalized or vulnerable populations, (4) interventions to generate demand and/or community acceptance. Outcomes assessed across the four questions included uptake of SRHS or sexual and reproductive health commodities and sexual and reproductive health biologic outcomes. There is limited evidence to support the effectiveness of initiatives that simply provide adolescent friendliness training for health workers. Data are most ample (10 initiatives demonstrating weak but positive effects and one randomized controlled trial demonstrating strong positive results on some outcome measures) for approaches that use a combination of health worker training, adolescent-friendly facility improvements, and broad information dissemination via the community, schools, and mass media. We found a paucity of evidence on out-of-facility-based strategies, except for those delivered through mixed-use youth centers that demonstrated that SRHS in these centers are neither well used nor effective at improving SRH outcomes. There was an absence of studies or evaluations examining outcomes among vulnerable or marginalized adolescents. Findings from 17 of 21 initiatives assessing demand-generation activities demonstrated at least some association with adolescent SRHS use. Of 15 studies on parental and other community gatekeepers' approval of SRHS for adolescents, which assessed SRHS/commodity uptake and/or biologic outcomes, 11 showed positive results. Packages of interventions that train health workers, improve facility adolescent friendliness, and endeavor to generate demand through multiple channels are ready for large-scale implementation. However, further evaluation of these initiatives is needed to clarify mechanisms and impact, especially of specific program components. Quality research is needed to determine effective means to deliver services outside the facilities, to reach marginalized or vulnerable adolescents, and to determine effective approaches to increase community acceptance of adolescent SRHS. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.
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Cybulski, Pamela; Zantinge, Johanna; Abbott-McNeil, Deanna
2006-01-01
The purpose of this quality improvement initiative was to improve the utilization of continuous lateral rotation therapy (CLRT) in a nine-bed community hospital ICU within the context of a nurse-driven protocol. Nursing focus groups, analyzed using a strength, weakness, opportunity, threat (SWOT) approach, resulted in the implementation of four interventions over seven weeks. Change management strategies guided all aspects of the project. Results showed a modest increase in the utilization of CLRT. This initiative demonstrates that change management strategies may assist with the incorporation of technology into nursing practice by increasing empowerment and creating an attachment to and responsibility for outcomes.
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Kim, Sae Hyun; Oh, Byung-Mo; Han, Tae Ryun; Jeong, Ho Joong
2015-01-01
Objective To identify the differences in the movement of the hyoid bone and the vocal cord with and without electrical stimulation in normal subjects. Methods Two-dimensional motion analysis using a videofluoroscopic swallowing study with and without electrical stimulation was performed. Surface electrical stimulation was applied during swallowing using electrodes placed at three different locations on each subject. All subjects were analyzed three times using the following electrode placements: with one pair of electrodes on the suprahyoid muscles and a second pair on the infrahyoid muscles (SI); with placement of the electrode pairs on only the infrahyoid muscles (IO); and with the electrode pairs placed vertically on the suprahyoid and infrahyoid muscles (SIV). Results The main outcomes of this study demonstrated an initial downward displacement as well as different movements of the hyoid bone with the three electrode placements used for electrical stimulation. The initial positions of the hyoid bone with the SI and IO placements resulted in an inferior and anterior displaced position. During swallowing, the hyoid bone moved in a more superior and less anterior direction, resulting in almost the same peak position compared with no electrical stimulation. Conclusion These results demonstrate that electrical stimulation caused an initial depression of the hyoid bone, which had nearly the same peak position during swallowing. Electrical stimulation during swallowing was not dependent on the position of the electrode on the neck, such as on the infrahyoid or on both the suprahyoid and infrahyoid muscles. PMID:26361589
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Initial Development and Pilot Study Design of Interactive Lecture Demonstrations for ASTRO 101
NASA Astrophysics Data System (ADS)
Schwortz, Andria C.; French, D. A; Gutierrez, Joseph V; Sanchez, Richard L; Slater, Timothy F.; Tatge, Coty
2014-06-01
Interactive lecture demonstrations (ILDs) have repeatedly shown to be effective tools for improving student achievement in the context of learning physics. As a first step toward systematic development of interactive lecture demonstrations in ASTRO 101, the introductory astronomy survey course, a systematic review of education research, describing educational computer simulations (ECSs) reveals that initial development requires a targeted study of how ASTRO 101 students respond to ECSs in the non-science majoring undergraduate lecture setting. In this project we have adopted the process by which ILDs were designed, pilot-tested, and successfully implemented in the context of physics teaching (Sokoloff & Thornton, 1997; Sokoloff & Thornton, 2004). We have designed the initial pilot-test set of ASTRO 101 ILD instructional materials relying heavily on ECSs. Both an instructor’s manual and a preliminary classroom-ready student workbook have been developed, and we are implementing a pilot study to explore their effectiveness in communicating scientific content, and the extent to which they might enhance students’ knowledge of and perception about astronomy and science in general. The study design uses a pre-/post-test quasi-experimental study design measuring students’ normalized gain scores, calculated as per Hake (1998) and Prather (2009), using a slightly modified version of S. Slater’s (2011) Test Of Astronomy STandards TOAST combined with other instruments. The results of this initial study will guide the iterative development of ASTRO 101 ILDs that are intended to both be effective at enhancing student achievement and easy for instructors to successfully implement.
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Code of Federal Regulations, 2014 CFR
2014-07-01
... Hazardous Air Pollutants for Iron and Steel Foundries Initial Compliance Requirements § 63.7735 How do I demonstrate initial compliance with the work practice standards that apply to me? (a) For each iron and steel...-consumer automotive body scrap, post-consumer engine blocks, post-consumer oil filters, oily turnings, lead...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... Hazardous Air Pollutants for Iron and Steel Foundries Initial Compliance Requirements § 63.7735 How do I demonstrate initial compliance with the work practice standards that apply to me? (a) For each iron and steel...-consumer automotive body scrap, post-consumer engine blocks, post-consumer oil filters, oily turnings, lead...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... Hazardous Air Pollutants for Iron and Steel Foundries Initial Compliance Requirements § 63.7735 How do I demonstrate initial compliance with the work practice standards that apply to me? (a) For each iron and steel...-consumer automotive body scrap, post-consumer engine blocks, post-consumer oil filters, oily turnings, lead...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... Pollutants for Iron and Steel Foundries Initial Compliance Requirements § 63.7735 How do I demonstrate initial compliance with the work practice standards that apply to me? (a) For each iron and steel foundry... automotive body scrap, post-consumer engine blocks, post-consumer oil filters, oily turnings, lead components...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... Hazardous Air Pollutants for Iron and Steel Foundries Initial Compliance Requirements § 63.7735 How do I demonstrate initial compliance with the work practice standards that apply to me? (a) For each iron and steel...-consumer automotive body scrap, post-consumer engine blocks, post-consumer oil filters, oily turnings, lead...
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Experiments in ultrasonic flaw detection using a MEMS transducer
NASA Astrophysics Data System (ADS)
Jain, Akash; Greve, David W.; Oppenheim, Irving J.
2003-08-01
In earlier work we developed a MEMS phased array transducer, fabricated in the MUMPs process, and we reported on initial experimental studies in which the device was affixed into contact with solids. We demonstrated the successful detection of signals from a conventional ultrasonic source, and the successful localization of the source in an off-axis geometry using phased array signal processing. We now describe the predicted transmission and coupling characteristics for such devices in contact with solids, demonstrating reasonable agreement with experimental behavior. We then describe the results of flaw detection experiments, as well as results for fluid-coupled detectors.
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Krewerth, D; Weidner, A; Biermann, H
2013-12-01
The present paper illustrates the application of infrared thermal measurements for the investigation of crack initiation point and crack propagation in the high-cycle and the very high-cycle fatigue range of cast AlSi7Mg alloy (A356). The influence of casting defects, their location, size and amount was studied both by fractography and thermography. Besides internal and surface fatigue crack initiation as a further crack initiation type multiple fatigue crack initiation was observed via in situ thermography which can be well correlated with the results from fractography obtained by SEM investigations. In addition, crack propagation was studied by the development of the temperature measured via thermography. Moreover, the frequency influence on high-cycle fatigue behaviour was investigated. The presented results demonstrate well that the combination of fractography and thermography can give a significant contribution to the knowledge of crack initiation and propagation in the VHCF regime. Copyright © 2013 Elsevier B.V. All rights reserved.
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Multibar sawless lint cleaner: Field testing results
USDA-ARS?s Scientific Manuscript database
The Multibar Sawless Lint Cleaner (MBSLC) is a prototype spiked-tooth lint cleaner initially designed to replace the first stage lint cleaning in a cotton gin. Previous studies conducted in the ginning laboratory in Lubbock, Texas, demonstrated improvements in some fiber properties, as well as minim...
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Liu, Jian; Miller, William H
2006-12-14
The thermal Gaussian approximation (TGA) recently developed by Frantsuzov et al. [Chem. Phys. Lett. 381, 117 (2003)] has been demonstrated to be a practical way for approximating the Boltzmann operator exp(-betaH) for multidimensional systems. In this paper the TGA is combined with semiclassical (SC) initial value representations (IVRs) for thermal time correlation functions. Specifically, it is used with the linearized SC-IVR (LSC-IVR, equivalent to the classical Wigner model), and the "forward-backward semiclassical dynamics" approximation developed by Shao and Makri [J. Phys. Chem. A 103, 7753 (1999); 103, 9749 (1999)]. Use of the TGA with both of these approximate SC-IVRs allows the oscillatory part of the IVR to be integrated out explicitly, providing an extremely simple result that is readily applicable to large molecular systems. Calculation of the force-force autocorrelation for a strongly anharmonic oscillator demonstrates its accuracy, and calculation of the velocity autocorrelation function (and thus the diffusion coefficient) of liquid neon demonstrates its applicability.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Khan, A.A.; Imai, A.; Tamaya, T.
Growing evidence suggests an association between intra-amniotic infection and premature initiation of parturition. We recently demonstrated that some factor(s) including endotoxin produced by the organism stimulates endogenous phospholipase A2 resulting in liberation of arachidonic acid and prostaglandin formation. The studies presented in this report were designated to evaluate the mechanism for endotoxin to stimulate phospholipase A2 using human endometrial fibroblasts. Exposure of the fibroblasts to endotoxin from Escherichia coli in the presence of ({sup 32}P) phosphate increased {sup 32}P-labeling of phosphatidic acid (PA) and phosphatidyl-inositol (PI) in a dose-dependent and a time-dependent manners. The PA labeling occurred without a measurablemore » lag time. These findings demonstrate that the endotoxin stimulates phosphoinositide metabolism in human endometrial fibroblasts by a receptor-mediated mechanism. Membrane phosphoinositide turnover stimulated by endotoxin results in cytosolic Ca{sup 2+} increment, liberation of arachidonic acid, which may be involved in the initiation of parturition.« less
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Code of Federal Regulations, 2013 CFR
2013-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Separators § 63.7911 How do I demonstrate initial...
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2015-07-06
preparation for deterministic spin-photon entanglement ; (3) Demonstration of initialization of the 2 qubit states; (4) Demonstration of nonlocal nuclear...Demonstration of a flying qubit by entanglement of the quantum dot spin polarization with the polarization of a spontaneously emitted photon. Future...coherent optical control steps in preparation for deterministic spin-photon entanglement ; (3) Demonstration of initialization of the 2 qubit states in
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Insight and search in Katona's five-square problem.
Ollinger, Michael; Jones, Gary; Knoblich, Günther
2014-01-01
Insights are often productive outcomes of human thinking. We provide a cognitive model that explains insight problem solving by the interplay of problem space search and representational change, whereby the problem space is constrained or relaxed based on the problem representation. By introducing different experimental conditions that either constrained the initial search space or helped solvers to initiate a representational change, we investigated the interplay of problem space search and representational change in Katona's five-square problem. Testing 168 participants, we demonstrated that independent hints relating to the initial search space and to representational change had little effect on solution rates. However, providing both hints caused a significant increase in solution rates. Our results show the interplay between problem space search and representational change in insight problem solving: The initial problem space can be so large that people fail to encounter impasse, but even when representational change is achieved the resulting problem space can still provide a major obstacle to finding the solution.
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Dobrinja, Chiara; Trevisan, Giuliano; Liguori, Gennaro
2009-03-01
The aim of this study is to analyze our preliminary results from minimally invasive video-assisted thyroidectomy (MIVAT) and demonstrate the feasibility of MIVAT also in non-referral centers. We report our initial experience based on a series of 47 patients selected for MIVAT at General Surgery Department of University of Trieste during a period from May 2005 to February 2007. The eligibility criteria were rigorously observed. Age, goiter volume, major diameter of the dominant nodule, operative times, pathologic findings, postoperative pain, length of hospital stay, cosmetic results, and complications were retrospectively analyzed. Thyroid lobectomy was successfully accomplished in 33 cases, total thyroidectomy in 14. Conversion to standard cervicotomy was required in three patients (6%). Mean operative time of lobectomy was 82.6 min and 118.7 for total thyroidectomy. Postoperative complications included 11 (23.4%) transient hypocalcemias, 2 (4.2%) hematomas, and 2 (4.2%) temporary laryngeal nerve palsies. None-recurrent nerve palsies was observed. The cosmetic result was excellent in most cases. Our experience demonstrates that MIVAT, after adequate training, is feasible and safe, with results comparable to conventional thyroidectomy, also in a General Surgery Department, from a dedicated team, with a sufficient and specific activity volume.
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NASA Astrophysics Data System (ADS)
Abbasbandy, S.; Van Gorder, R. A.; Hajiketabi, M.; Mesrizadeh, M.
2015-10-01
We consider traveling wave solutions to the Casimir equation for the Ito system (a two-field extension of the KdV equation). These traveling waves are governed by a nonlinear initial value problem with an interesting nonlinearity (which actually amplifies in magnitude as the size of the solution becomes small). The nonlinear problem is parameterized by two initial constant values, and we demonstrate that the existence of solutions is strongly tied to these parameter values. For our interests, we are concerned with positive, bounded, periodic wave solutions. We are able to classify parameter regimes which admit such solutions in full generality, thereby obtaining a nice existence result. Using the existence result, we are then able to numerically simulate the positive, bounded, periodic solutions. We elect to employ a group preserving scheme in order to numerically study these solutions, and an outline of this approach is provided. The numerical simulations serve to illustrate the properties of these solutions predicted analytically through the existence result. Physically, these results demonstrate the existence of a type of space-periodic structure in the Casimir equation for the Ito model, which propagates as a traveling wave.
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DOT National Transportation Integrated Search
2012-05-01
This report provides an analytical framework for evaluating the two field deployments under the United States Department of Transportation (U.S. DOT) Integrated Corridor Management (ICM) Initiative Demonstration Phase. The San Diego Interstate 15 cor...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF... Solid Waste Incineration Units Model Rule-Initial Compliance Requirements § 60.2700 How do I demonstrate...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF... Solid Waste Incineration Units Model Rule-Initial Compliance Requirements § 60.2700 How do I demonstrate...
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Godycki-Cwirko, Maciek; Esmail, Aneez; Dovey, Susan; Wensing, Michel; Parker, Dianne; Kowalczyk, Anna; Błaszczyk, Honorata; Kosiek, Katarzyna
2015-01-01
ABSTRACT Background: Despite patient safety being recognized as an important healthcare issue in the European Union, there has been variable implementation of patient safety initiatives in Central and Eastern Europe (CEE). Objective: To assess the status of patient safety initiatives in countries in CEE; to describe a process of engagement in Poland, which can serve as a template for the implementation of patient safety initiatives in primary care. Methods: A mixed methods design was used. We conducted a review of literature focusing on publications from CEE, an inventory of patient safety initiatives in CEE countries, interviews with key informants, international survey, review of national reporting systems, and pilot demonstrator project in Poland with implementation of patient safety toolkits assessment. Results: There was no published patient safety research from Albania, Belarus, Greece, Latvia, Lithuania, Romania, or Russia. Nine papers were found from Bulgaria, Croatia, the Czech Republic, Poland, Serbia, and Slovenia. In most of the CEE countries, patient safety had been addressed at the policy level although the focus was mainly in hospital care. There was a dearth of activity in primary care. The use of patient improvement strategies was low. Conclusion: International cooperation as exemplified in the demonstrator project can help in the development and implementation of patient safety initiatives in primary care in changing the emphasis away from a blame culture to one where greater emphasis is placed on improvement and learning. PMID:26339839
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κ chain monoallelic demethylation and the establishment of allelic exclusion
Mostoslavsky, Raul; Singh, Nandita; Kirillov, Andrei; Pelanda, Roberta; Cedar, Howard; Chess, Andrew; Bergman, Yehudit
1998-01-01
Allelic exclusion in κ light-chain synthesis is thought to result from a feedback mechanism by which the expression of a functional κ light chain on the surface of the B cell leads to an intracellular signal that down-regulates the V(D)J recombinase, thus precluding rearrangement of the other allele. Whereas such a feedback mechanism clearly plays a role in the maintenance of allelic exclusion, here we provide evidence suggesting that the initial establishment of allelic exclusion involves differential availability of the two κ alleles for rearrangement. Analysis of κ+ B-cell populations and of individual κ+ B cells that have rearranged only one allele demonstrates that in these cells, critical sites on the rearranged allele are unmethylated, whereas the nonrearranged allele remains methylated. This pattern is apparently generated by demethylation that is initiated at the small pre-B cell stage, on a single allele, in a process that occurs prior to rearrangement and requires the presence in cis of both the intronic and 3′ κ enhancers. Taken together with data demonstrating that undermethylation is required for rearrangement, these results indicate that demethylation may actually underly the process of allelic exclusion by directing the initial choice of a single κ allele for rearrangement. PMID:9637682
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Temporal Evolution of the Plasma Sheath Surrounding Solar Cells in Low Earth Orbit
NASA Technical Reports Server (NTRS)
Willis, Emily M.; Pour, Maria Z. A.
2017-01-01
Initial results from the PIC simulation and the LEM simulation have been presented. The PIC simulation results show that more detailed study is required to refine the ISS solar array current collection model and to understand the development of the current collection in time. The initial results from the LEM demonstrate that is it possible the transients are caused by solar array interaction with the environment, but there are presently too many assumptions in the model to be certain. Continued work on the PIC simulation will provide valuable information on the development of the barrier potential, which will allow refinement the LEM simulation and a better understanding of the causes and effects of the transients.
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Effects of Grain Size and Twin Layer Thickness on Crack Initiation at Twin Boundaries.
Zhou, Piao; Zhou, Jianqiu; Zhu, Yongwei; Jiang, E; Wang, Zikun
2018-04-01
A theoretical model to explore the effect on crack initiation of nanotwinned materials was proposed based on the accumulation of dislocations at twin boundaries. First, a critical cracking initiation condition was established considering the number of dislocations pill-up at TBs, grain size and twin layer thickness, and a semi-quantitative relationship between the crystallographic orientation and the stacking fault energy was built. In addition, the number of dislocations pill-up was described by introducing the theory of strain gradient. Based on this model, the effects of grain size and twin lamellae thickness on dislocation density and crack initiation at twin boundaries were also discussed. The simulation results demonstrated that the crack initiation resistance can be improved by decreasing the grain size and increasing the twin lamellae, which keeps in agreement with recent experimental findings reported in the literature.
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Histological relationship of Phytobia setosa to Acer saccharum
Robert Gregory; William Wallner
1979-01-01
The maple cambium miner, Phytobia setosa (Loew), attacks Acer spp., producing ray flecks which result in degrade in face veneer and furniture wood. Samples from infested sugar maple, Acer saccharum Marsh, trees demonstrated that while mines passed close to the vascular cambium the initial cells were not...
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Sleeve expansion of bolt holes in railroad rail. volume III - field experiment results
DOT National Transportation Integrated Search
1998-02-01
The bolt-hole cold-expansion process has been demonstrated by laboratory tests to significantly affect the initiation and propagation of fatigue cracks from rail bolt holes such that a reduction of the incidence of rail-bolt-holde failure in cold-exp...
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DOT National Transportation Integrated Search
1998-09-01
This flyer summarizes the activities and results of a preliminary human factors review for the Intelligent Vehicle Initiative (IVI) Program. As part of the IVI program, the Federal Highway Administration funded a project to investigate the human fact...
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Image registration based on subpixel localization and Cauchy-Schwarz divergence
NASA Astrophysics Data System (ADS)
Ge, Yongxin; Yang, Dan; Zhang, Xiaohong; Lu, Jiwen
2010-07-01
We define a new matching metric-corner Cauchy-Schwarz divergence (CCSD) and present a new approach based on the proposed CCSD and subpixel localization for image registration. First, we detect the corners in an image by a multiscale Harris operator and take them as initial interest points. And then, a subpixel localization technique is applied to determine the locations of the corners and eliminate the false and unstable corners. After that, CCSD is defined to obtain the initial matching corners. Finally, we use random sample consensus to robustly estimate the parameters based on the initial matching. The experimental results demonstrate that the proposed algorithm has a good performance in terms of both accuracy and efficiency.
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Luminorefrigeration: vibrational cooling of NaCs.
Wakim, A; Zabawa, P; Haruza, M; Bigelow, N P
2012-07-02
We demonstrate the use of optical pumping of kinetically ultracold NaCs to cool an initial vibrational distribution of electronic ground state molecules X(1)Σ(+)(v ≥ 4) into the vibrational ground state X(1)Σ(+)(v=0). Our approach is based on the use of simple, commercially available multimode diode lasers selected to optically pump population into X(1)Σ(+)(v=0). We investigate the impact of the cooling process on the rotational state distribution of the vibrational ground state, and observe that an initial distribution, J(initial)=0-2 is only moderately affected resulting in J(final)=0-4. This method provides an inexpensive approach to creation of vibrational ground state ultracold polar molecules.
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Butler, Ruth
2006-09-01
The aims of this research were to examine the predictions that (a) the kind of evaluation pupils anticipate will influence their initial achievement goals and, as a result, the quality and consequences of task engagement; and (b) initial mastery goals will promote new learning and intrinsic motivation and initial ability goals will promote entity beliefs that ability is fixed. Participants were 312 secondary school pupils at ages 13-15. Pupils expected to receive normative evaluation, temporal evaluation (scores over time) or no evaluation. Mastery and ability goals were measured before pupils worked on challenging problems; intrinsic motivation and entity beliefs were measured after task completion. Anticipation of temporal evaluation enhanced initial mastery goals, anticipation of normative evaluation enhanced ability goals and the no-evaluation condition undermined both. Anticipation of temporal evaluation enhanced new learning (strategy acquisition and performance gains) and intrinsic motivation both directly and by enhancing initial mastery goals; anticipation of normative evaluation enhanced entity beliefs by enhancing ability goals. Results confirmed that evaluation conveys potent cues as to the goals of activity. They also challenged claims that both mastery and ability goals can be adaptive by demonstrating that these were differentially associated with positive versus negative processes and outcomes. Results have theoretical and applied implications for understanding and improving evaluative practices and student motivation.
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Yu, Yuguo; Shu, Yousheng; McCormick, David A.
2008-01-01
Neocortical action potential responses in vivo are characterized by considerable threshold variability, and thus timing and rate variability, even under seemingly identical conditions. This finding suggests that cortical ensembles are required for accurate sensorimotor integration and processing. Intracellularly, trial-to-trial variability results not only from variation in synaptic activities, but also in the transformation of these into patterns of action potentials. Through simultaneous axonal and somatic recordings and computational simulations, we demonstrate that the initiation of action potentials in the axon initial segment followed by backpropagation of these spikes throughout the neuron results in a distortion of the relationship between the timing of synaptic and action potential events. In addition, this backpropagation also results in an unusually high rate of rise of membrane potential at the foot of the action potential. The distortion of the relationship between the amplitude time course of synaptic inputs and action potential output caused by spike back-propagation results in the appearance of high spike threshold variability at the level of the soma. At the point of spike initiation, the axon initial segment, threshold variability is considerably less. Our results indicate that spike generation in cortical neurons is largely as expected by Hodgkin—Huxley theory and is more precise than previously thought. PMID:18632930
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Controlled Ecological Life Support System: Research and Development Guidelines
NASA Technical Reports Server (NTRS)
Mason, R. M. (Editor); Carden, J. L. (Editor)
1982-01-01
Results of a workshop designed to provide a base for initiating a program of research and development of controlled ecological life support systems (CELSS) are summarized. Included are an evaluation of a ground based manned demonstration as a milestone in CELSS development, and a discussion of development requirements for a successful ground based CELSS demonstration. Research recommendations are presented concerning the following topics: nutrition and food processing, food production, waste processing, systems engineering and modelling, and ecology-systems safety.
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Jaworski, Piotr; Nikodem, Michał
2018-01-01
In this paper, we present a system for sequential detection of multiple gases using laser-based wavelength modulation spectroscopy (WMS) method combined with a Herriot-type multi-pass cell. Concentration of hydrogen sulfide (H2S), methane (CH4), carbon dioxide (CO2), and ammonia (NH3) are retrieved using three distributed feedback laser diodes operating at 1574.5 nm (H2S and CO2), 1651 nm (CH4), and 1531 nm (NH3). Careful adjustment of system parameters allows for H2S sensing at single parts-per-million by volume (ppmv) level with strongly reduced interference from adjacent CO2 transitions even at atmospheric pressure. System characterization in laboratory conditions is presented and the results from initial tests in real-world application are demonstrated. PMID:29425175
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Sly, D F; Hopkins, R S; Trapido, E; Ray, S
2001-01-01
OBJECTIVES: The purpose of this study was to assess the short-term effects of television advertisements from the Florida "truth" campaign on rates of smoking initiation. METHODS: A follow-up survey of young people aged 12 to 17 years (n = 1820) interviewed during the first 6 months of the advertising campaign was conducted. Logistic regression analyses were used to estimate the independent effects of the campaign on smoking initiation while other factors were controlled for. RESULTS: Youths scoring at intermediate and high levels on a media effect index were less likely to initiate smoking than youths who could not confirm awareness of television advertisements. Adjusted odds ratios between the media index and measures of initiation were similar within categories of age, sex, susceptibility, and whether a parent smoked. CONCLUSIONS: Exposure to the "truth" media campaign lowered the risk of youth smoking initiation. However, the analysis did not demonstrate that all such media programs will be effective. PMID:11211631
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Mixed convective/dynamic roll vortices and their effects on initial wind and temperature profiles
NASA Technical Reports Server (NTRS)
Haack, Tracy; Shirer, Hampton N.
1991-01-01
The onset and development of both dynamically and convectively forced boundary layer rolls are studied with linear and nonlinear analyses of a truncated spectral model of shallow Boussinesq flow. Emphasis is given here on the energetics of the dominant roll modes, on the magnitudes of the roll-induced modifications of the initial basic state wind and temperature profiles, and on the sensitivity of the linear stability results to the use of modified profiles as basic states. It is demonstrated that the roll circulations can produce substantial changes to the cross-roll component of the initial wind profile and that significant changes in orientation angle estimates can result from use of a roll-modified profile in the stability analysis. These results demonstrate that roll contributions must be removed from observed background wind profiles before using them to investigate the mechanisms underlying actual secondary flows in the boundary layer. The model is developed quite generally to accept arbitrary basic state wind profiles as dynamic forcing. An Ekman profile is chosen here merely to provide a means for easy comparison with other theoretical boundary layer studies; the ultimate application of the model is to study observed boundary layer profiles. Results of the analytic stability analysis are validated by comparing them with results from a larger linear model. For an appropriate Ekman depth, a complete set of transition curves is given in forcing parameter space for roll modes driven both thermally and dynamically. Preferred orientation angles, horizontal wavelengths and propagation frequencies, as well as energetics and wind profile modifications, are all shown to agree rather well with results from studies on Ekman layers as well as with studies on near-neutral and convective atmospheric boundary layers.
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Project Developmental Continuity Evaluation: Final Report. Executive Summary.
ERIC Educational Resources Information Center
Bond, James T.; Rosario, Jose
This executive summary presents the major results of the longitudinal evaluation of Project Developmental Continuity (PDC). A Head Start demonstration project initiated by the Administration for Children, Youth and Families (ACYF) in 1974, the PDC aimed to stimulate the development and implementation of comprehensive programs linking Head Start…
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40 CFR 63.4312 - What records must I keep?
Code of Federal Regulations, 2010 CFR
2010-07-01
... based on testing, you must keep the summary sheet of results provided to you by the manufacturer or... and printing materials. If you conducted testing to determine mass fraction of organic HAP of coating... operated within the operating scenarios used to demonstrate initial compliance, documentation that affected...
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The Predictive Validity of the Metropolitan Readiness Tests, 1976 Edition.
ERIC Educational Resources Information Center
Nagle, Richard J.
1979-01-01
A sample of 176 first-grade children was tested on the Metropolitan Readiness Tests, 1976 Edition (MRT), during the initial month of school and was retested eight months later on the Stanford Achievement Test. Results demonstrated substantial validity of the MRT for predicting first-grade achievement. (Author/CTM)
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Wheat productivity estimates using LANDSAT data. [Michigan
NASA Technical Reports Server (NTRS)
Nalepka, R. F.; Colwell, J. (Principal Investigator); Rice, D. P.
1977-01-01
The author has identified the following significant results. An initial demonstration was made of the capability to make direct production forecasts for winter wheat using early season LANDSAT data. The approach offers the potential to make production forecasts quickly and simply, possibly avoiding some of the complexities of alternate procedures.
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Sensory Integration and Ego Development in a Schizophrenic Adolescent Male.
ERIC Educational Resources Information Center
Pettit, Karen A.
1987-01-01
A retrospective study compared hours spent by a schizophrenic adolescent in "time out" before and after initiation of treatment. The study evaluated the effects of sensory integrative treatment on the ability to handle anger and frustration. Results demonstrate the utility of statistical analysis versus visual comparison to validate effectiveness…
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SATWG networked quality function deployment
NASA Technical Reports Server (NTRS)
Brown, Don
1992-01-01
The initiative of this work is to develop a cooperative process for continual evolution of an integrated, time phased avionics technology plan that involves customers, technologists, developers, and managers. This will be accomplished by demonstrating a computer network technology to augment the Quality Function Deployment (QFD). All results are presented in viewgraph format.
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DOT National Transportation Integrated Search
2012-08-01
This report presents the test plan for conducting the Corridor Performance Analysis for the United States Department of Transportation (U.S. DOT) evaluation of the Dallas U.S. 75 Integrated Corridor Management (ICM) Initiative Demonstration. The ICM ...
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DOT National Transportation Integrated Search
2012-08-01
This report presents the test plan for conducting the Corridor Performance Analysis for the United States Department of Transportation (U.S. DOT) evaluation of the San Diego Integrated Corridor Management (ICM) Initiative Demonstration. The ICM proje...
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DOT National Transportation Integrated Search
2012-08-01
This report presents the test plan for conducting the Decision Support System (DSS) Analysis for the United States Department of Transportation (U.S. DOT) evaluation of the Dallas U.S. 75 Integrated Corridor Management (ICM) Initiative Demonstration....
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DOT National Transportation Integrated Search
2012-08-01
This report presents the test plan for conducting the Technical Capability Analysis for the United States Department of Transportation (U.S. DOT) evaluation of the Dallas U.S. 75 Integrated Corridor Management (ICM) Initiative Demonstration. The ICM ...
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Time's arrow: A numerical experiment
NASA Astrophysics Data System (ADS)
Fowles, G. Richard
1994-04-01
The dependence of time's arrow on initial conditions is illustrated by a numerical example in which plane waves produced by an initial pressure pulse are followed as they are multiply reflected at internal interfaces of a layered medium. Wave interactions at interfaces are shown to be analogous to the retarded and advanced waves of point sources. The model is linear and the calculation is exact and demonstrably time reversible; nevertheless the results show most of the features expected of a macroscopically irreversible system, including the approach to the Maxwell-Boltzmann distribution, ergodicity, and concomitant entropy increase.
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Small sample estimation of the reliability function for technical products
NASA Astrophysics Data System (ADS)
Lyamets, L. L.; Yakimenko, I. V.; Kanishchev, O. A.; Bliznyuk, O. A.
2017-12-01
It is demonstrated that, in the absence of big statistic samples obtained as a result of testing complex technical products for failure, statistic estimation of the reliability function of initial elements can be made by the moments method. A formal description of the moments method is given and its advantages in the analysis of small censored samples are discussed. A modified algorithm is proposed for the implementation of the moments method with the use of only the moments at which the failures of initial elements occur.
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Lesser, Mark R; Jackson, Stephen T
2013-03-01
Long-distance dispersal is an integral part of plant species migration and population development. We aged and genotyped 1125 individuals in four disjunct populations of Pinus ponderosa that were initially established by long-distance dispersal in the 16th and 17th centuries. Parentage analysis was used to determine if individuals were the product of local reproductive events (two parents present), long-distance pollen dispersal (one parent present) or long-distance seed dispersal (no parents present). All individuals established in the first century at each site were the result of long-distance dispersal. Individuals reproduced at younger ages with increasing age of the overall population. These results suggest Allee effects, where populations were initially unable to expand on their own, and were dependent on long-distance dispersal to overcome a minimum-size threshold. Our results demonstrate that long-distance dispersal was not only necessary for initial colonisation but also to sustain subsequent population growth during early phases of expansion. © 2012 Blackwell Publishing Ltd/CNRS.
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Zhang, Tao; Zhu, Yongyun; Zhou, Feng; Yan, Yaxiong; Tong, Jinwu
2017-06-17
Initial alignment of the strapdown inertial navigation system (SINS) is intended to determine the initial attitude matrix in a short time with certain accuracy. The alignment accuracy of the quaternion filter algorithm is remarkable, but the convergence rate is slow. To solve this problem, this paper proposes an improved quaternion filter algorithm for faster initial alignment based on the error model of the quaternion filter algorithm. The improved quaternion filter algorithm constructs the K matrix based on the principle of optimal quaternion algorithm, and rebuilds the measurement model by containing acceleration and velocity errors to make the convergence rate faster. A doppler velocity log (DVL) provides the reference velocity for the improved quaternion filter alignment algorithm. In order to demonstrate the performance of the improved quaternion filter algorithm in the field, a turntable experiment and a vehicle test are carried out. The results of the experiments show that the convergence rate of the proposed improved quaternion filter is faster than that of the tradition quaternion filter algorithm. In addition, the improved quaternion filter algorithm also demonstrates advantages in terms of correctness, effectiveness, and practicability.
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An adaptive control scheme for a flexible manipulator
NASA Technical Reports Server (NTRS)
Yang, T. C.; Yang, J. C. S.; Kudva, P.
1987-01-01
The problem of controlling a single link flexible manipulator is considered. A self-tuning adaptive control scheme is proposed which consists of a least squares on-line parameter identification of an equivalent linear model followed by a tuning of the gains of a pole placement controller using the parameter estimates. Since the initial parameter values for this model are assumed unknown, the use of arbitrarily chosen initial parameter estimates in the adaptive controller would result in undesirable transient effects. Hence, the initial stage control is carried out with a PID controller. Once the identified parameters have converged, control is transferred to the adaptive controller. Naturally, the relevant issues in this scheme are tests for parameter convergence and minimization of overshoots during control switch-over. To demonstrate the effectiveness of the proposed scheme, simulation results are presented with an analytical nonlinear dynamic model of a single link flexible manipulator.
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Raub, Steffen; Liao, Hui
2012-05-01
We developed and tested a cross-level model of the antecedents and outcomes of proactive customer service performance. Results from a field study of 900 frontline service employees and their supervisors in 74 establishments of a multinational hotel chain located in Europe, the Middle East, Africa, and Asia demonstrated measurement equivalence and suggested that, after controlling for service climate, initiative climate at the establishment level and general self-efficacy at the individual level predicted employee proactive customer service performance and interacted in a synergistic way. Results also showed that at the establishment level, controlling for service climate and collective general service performance, initiative climate was positively and indirectly associated with customer service satisfaction through the mediation of aggregated proactive customer service performance. We discuss important theoretical and practical implications of these findings. (PsycINFO Database Record (c) 2012 APA, all rights reserved).
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Dynamic propagation of symmetric Airy pulses with initial chirps in an optical fiber
NASA Astrophysics Data System (ADS)
Shi, Xiaohui; Huang, Xianwei; Deng, Yangbao; Tan, Chao; Bai, Yanfeng; Fu, Xiquan
2017-09-01
We analytically and numerically investigate the propagation dynamics of initially chirped symmetric Airy pulses in an optical fiber. The results show that the positive chirps act to promote the interference in generating a focal point on the propagation axis, while the negative chirps tend to suppress the focusing effect, as compared to conventional unchirped symmetric Airy pulses. The numerical results demonstrate that the linear propagation of chirped symmetric Airy pulses depend considerably on the chirp parameter and the primary lobe position. In the anomalous dispersion region, positively chirped symmetric Airy pulses first undergo an initial compression, and reach a foci due to the opposite acceleration, and then experience a lossy inversion transformation, and come to the opposite facing focal position. The impact of truncation coefficient and Kerr nonlinearity on the chirped symmetric Airy pulses propagation is also disclosed separately.
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Observations of specular reflective particles and layers in crystal clouds.
Balin, Yurii S; Kaul, Bruno V; Kokhanenko, Grigorii P; Penner, Ioganes E
2011-03-28
In the present article, results of observations of high crystal clouds with high spatial and temporal resolution using the ground-based polarization LOSA-S lidar are described. Cases of occurrence of specularly reflective layers formed by particles oriented predominantly in the horizontal plane are demonstrated. Results of measuring echo-signal depolarization are compared for linear and circular polarization states of the initial laser beam.
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Fixation of Radiological Contamination; International Collaborative Development
DOE Office of Scientific and Technical Information (OSTI.GOV)
Rick Demmer
2013-03-01
A cooperative international project was conducted by the Idaho National Laboratory (INL) and the United Kingdom’s National Nuclear Laboratory (NNL) to integrate a capture coating with a high performance atomizing process. The initial results were promising, and lead to further trials. The somewhat longer testing and optimization process has resulted in a product that could be demonstrated in the field to reduce airborne radiological dust and contamination.
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Multiple scene attitude estimator performance for LANDSAT-1
NASA Technical Reports Server (NTRS)
Rifman, S. S.; Monuki, A. T.; Shortwell, C. P.
1979-01-01
Initial results are presented to demonstrate the performance of a linear sequential estimator (Kalman Filter) used to estimate a LANDSAT 1 spacecraft attitude time series defined for four scenes. With the revised estimator a GCP poor scene - a scene with no usable geodetic control points (GCPs) - can be rectified to higher accuracies than otherwise based on the use of GCPs in adjacent scenes. Attitude estimation errors was determined by the use of GCPs located in the GCP-poor test scene, but which are not used to update the Kalman filter. Initial results achieved indicate that errors of 500m (rms) can be attained for the GCP-poor scenes. Operational factors are related to various scenarios.
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Pseudorapidity correlations in heavy ion collisions from viscous fluid dynamics
Monnai, A.; Schenke, B.
2015-11-26
We demonstrate by explicit calculations in 3+1 dimensional viscous relativistic fluid dynamics how two-particle pseudorapidity correlation functions in heavy ion collisions at the LHC and RHIC depend on the number of particle producing sources and the transport properties of the produced medium. In particular, we present results for the Legendre coefficients of the two-particle pseudorapidity correlation function, a n,m, in Pb+Pb collisions at 2760 GeV and Au+Au collisions at 200 GeV from viscous hydrodynamics with three dimensionally fluctuating initial conditions. Our results suggest that the a n,m provide important constraints on initial state fluctuations and the transport properties of themore » quark gluon plasma.« less
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Stormwater quality modelling in combined sewers: calibration and uncertainty analysis.
Kanso, A; Chebbo, G; Tassin, B
2005-01-01
Estimating the level of uncertainty in urban stormwater quality models is vital for their utilization. This paper presents the results of application of a Monte Carlo Markov Chain method based on the Bayesian theory for the calibration and uncertainty analysis of a storm water quality model commonly used in available software. The tested model uses a hydrologic/hydrodynamic scheme to estimate the accumulation, the erosion and the transport of pollutants on surfaces and in sewers. It was calibrated for four different initial conditions of in-sewer deposits. Calibration results showed large variability in the model's responses in function of the initial conditions. They demonstrated that the model's predictive capacity is very low.
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Develop and test fuel cell powered on-site integrated total energy system
NASA Technical Reports Server (NTRS)
1983-01-01
Test results are given for a 5 kW stack and initial results for an integrated, grid connected system operating from methanol fuel. Site selection criteria are presented for future demonstration of a 50 or 100 kW OS/IES. Preliminary results are also given with approximate internal rates of return to the building owner. Progress in development and construction of a 50 kW modular methanol/steam reformer is reported.
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NASA Technical Reports Server (NTRS)
Chevalley, Eric
2016-01-01
The Charlotte EDC Evaluation and Demonstration (CEED) was the first Human-In-The-Loop experiment under the Air Traffic Management Technology Demonstration-2 (ATD-2) project. The purpose of the study was fourfold: 1) to establish a simulation environment (Charlotte) for airspace operations for ATD-2 technology, 2) to simulate current-day departures and arrival operations, 3) to assess the impact of current Traffic Management Initiatives (TMI) on Charlotte (CLT) departure flows and en route operations in Washington (ZDC) and Atlanta Centers (ZTL), and 4) to assess the impact of departure takeoff time compliance on airspace operations. The experimental design compared 3 TMIs and 2 compliance levels. Fourteen FAA retired controllers participated in the simulation. In addition, two Traffic Management Coordinators from ZTL and ZDC managed traffic flows. Surface and airborne delays, control efficiency, throughput, realism, workload, and acceptability were assessed and will be compared across the experimental conditions. Participants rated the simulation as very realistic. Results indicate that different TMIs have different impacts on surface and airspace delay. Departure compliance indicates partial benefits to sector complexity and controller workload. This simulation will provide an initial assessment of the tactical scheduling problems that the ATD-2 technology will address in the near term.
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NASA Astrophysics Data System (ADS)
Shafirovich, Vladimir; Singh, Carolyn; Geacintov, Nicholas E.
2003-11-01
Oxidative damage of DNA molecules associated with electron-transfer reactions is an important phenomenon in living cells, which can lead to mutations and contribute to carcinogenesis and the aging processes. This article describes the design of several simple experiments to explore DNA damage initiated by photoinduced electron-transfer reactions sensitized by the acridine derivative, proflavine (PF). A supercoiled DNA agarose gel nicking assay is employed as a sensitive probe of DNA strand cleavage. A low-cost experimental and computer-interfaced imaging apparatus is described allowing for the digital recording and analysis of the gel electrophoresis results. The first experiment describes the formation of direct strand breaks in double-stranded DNA induced by photoexcitation of the intercalated PF molecules. The second experiment demonstrates that the addition of the well-known electron acceptor, methylviologen, gives rise to a significant enhancement of the photochemical DNA strand cleavage effect. This occurs by an electron transfer step to methylviologen that renders the inital photoinduced charge separation between photoexcited PF and DNA irreversible. The third experiment demonstrates that the action spectrum of the DNA photocleavage matches the absorption spectrum of DNA-bound, intercalated PF molecules, which differs from that of free PF molecules. This result demonstrates that the photoinduced DNA strand cleavage is initiated by intercalated rather than free PF molecules.
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Bioprocessing of a stored mixed liquid waste
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wolfram, J.H.; Rogers, R.D.; Finney, R.
1995-12-31
This paper describes the development and results of a demonstration for a continuous bioprocess for mixed waste treatment. A key element of the process is an unique microbial strain which tolerates high levels of aromatic solvents and surfactants. This microorganism is the biocatalysis of the continuous flow system designed for the processing of stored liquid scintillation wastes. During the past year a process demonstration has been conducted on commercial formulation of liquid scintillation cocktails (LSC). Based on data obtained from this demonstration, the Ohio EPA granted the Mound Applied Technologies Lab a treatability permit allowing the limited processing of actualmore » mixed waste. Since August 1994, the system has been successfully processing stored, {open_quotes}hot{close_quotes} LSC waste. The initial LSC waste fed into the system contained 11% pseudocumene and detectable quantities of plutonium. Another treated waste stream contained pseudocumene and tritium. Data from this initial work shows that the hazardous organic solvent, and pseudocumene have been removed due to processing, leaving the aqueous low level radioactive waste. Results to date have shown that living cells are not affected by the dissolved plutonium and that 95% of the plutonium was sorbed to the biomass. This paper discusses the bioprocess, rates of processing, effluent, and the implications of bioprocessing for mixed waste management.« less
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DOT National Transportation Integrated Search
2012-08-01
This report presents the test plan for conducting the Benefit-Cost Analysis (BCA) for the United States Department of Transportation (U.S. DOT) evaluation of the San Diego Integrated Corridor Management (ICM) Initiative Demonstration. The ICM project...
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Acetogenic microbial degradation of vinyl chloride
Bradley, P.M.; Chapelle, F.H.
2000-01-01
Under methanogenic conditions, microbial degradation of [1,2-14C]vinyl chloride (VC) resulted in significant (14 ?? 3% maximum recovery) but transient recovery of radioactivity as 14C-acetate. Subsequently, 14C- acetate was degraded to 14CH4 and 14CO2 (18 ?? 2% and 54 ?? 3% final recoveries, respectively). In contrast, under 2-bromoethanesulfonic acid (BES) amended conditions, 14C-acetate recovery remained high (27 ?? 1% maximum recovery) throughout the study, no 14CH4 was produced, and the final recovery of 14CO2 was only 35 ?? 4%. These results demonstrate that oxidative acetogenesis may be an important mechanism for anaerobic VC biodegradation. Moreover, these results (1) demonstrate that microbial degradation of VC to CH4 and CO2 may involve oxidative acetogenesis followed by acetotrophic methanogenesis and (2) suggest that oxidative acetogenesis may be the initial step in the net oxidation of VC to CO2 reported previously under Fe(III)-reducing, SO4-reducing, and humic acids- reducing conditions.Under methanogenic conditions, microbial degradation of [1,2-14C]vinyl chloride (VC) resulted in significant (14 ?? 3% maximum recovery) but transient recovery of radioactivity as 14C-acetate. Subsequently, 14C-acetate was degraded to 14CH4 and 14CO2 (18 ?? 2% and 54 ?? 3% final recoveries respectively). In contrast, under 2-bromoethanesulfonic acid (BES) amended conditions, 14C-acetate recovery remained high (27 ?? 1% maximum recovery) throughout the study, no 14CH4 was produced, and the final recovery of 14CO2 was only 35 ?? 4%. These results demonstrate that oxidative acetogenesis may be an important mechanism for anaerobic VC biodegradation. Moreover, these results (1) demonstrate that microbial degradation of VC to CH4 and CO2 may involve oxidative acetogenesis followed by acetotrophic methanogenesis and (2) suggest that oxidative acetogenesis may be the initial step in the net oxidation of VC to CO2 reported previously under Fe(III)-reducing, SO4-reducing, and humic acids-reducing conditions.
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Development and initial test of the University of Wisconsin global isentropic-sigma model
NASA Technical Reports Server (NTRS)
Zapotocny, Tom H.; Johnson, Donald R.; Reames, Fred M.
1994-01-01
The description of a global version of the University of Wisconsin (UW) hybrid isentropic-sigma (theta-sigma) model and the results from an initial numerical weather prediction experiment are presented in this paper. The main objectives of this initial test are to (1) discuss theta-sigma model development and computer requirements, (2) demonstrate the ability of the UW theta-sigma model for global numerical weather prediction using realistic orography and parameterized physical processes, and (3) compare the transport of an inert trace constituent against a nominally 'identical' sigma coordinate model. Initial and verifying data for the 5-day simulations presented in this work were supplied by the Goddard Earth Observing System (GEOS-1) data assimilation system. The time period studied is 1-6 February 1985. This validation experiment demonstrates that the global UW theta-sigma model produces a realistic 5-day simulation of the mass and momentum distributions when compared to both the identical sigma model and GEOS-1 verification. Root-mean-square errors demonstrate that the theta-sigma model is slightly more accurate than the nominally identical sigma model with respect to standard synoptic variables. Of particular importance, the UW theta-sigma model displays a distinct advantage over the conventional sigma model with respect to the prognostic simulation of inert trace constituent transport in amplifying baroclinic waves of the extratropics. This is especially true in the upper troposphere and stratosphere where the spatial integrity and conservation of an inert trace constituent is severely compromised in the sigma model compared to the theta-sigma model.
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Epistemic Beliefs and Conceptual Understanding in Biotechnology: A Case Study
NASA Astrophysics Data System (ADS)
Rebello, Carina M.; Siegel, Marcelle A.; Witzig, Stephen B.; Freyermuth, Sharyn K.; McClure, Bruce A.
2012-04-01
The purpose of this investigation was to explore students' epistemic beliefs and conceptual understanding of biotechnology. Epistemic beliefs can influence reasoning, how individuals evaluate information, and informed decision making abilities. These skills are important for an informed citizenry that will participate in debates regarding areas in science such as biotechnology. We report on an in-depth case study analysis of three undergraduate, non-science majors in a biotechnology course designed for non-biochemistry majors. We selected participants who performed above average and below average on the first in-class exam. Data from multiple sources—interviews, exams, and a concept instrument—were used to construct (a) individual profiles and (b) a cross-case analysis of our participants' conceptual development and epistemic beliefs from two different theoretical perspectives—Women's Ways of Knowing and the Reflective Judgment Model. Two independent trained researchers coded all case records independently for both theoretical perspectives, with resultant initial Cohen's kappa values above .715 (substantial agreement), and then reached consensus on the codes. Results indicate that a student with more sophisticated epistemology demonstrated greater conceptual understandings at the end of the course than a student with less sophisticated epistemology, even though the latter performed higher initially. Also a student with a less sophisticated epistemology and low initial conceptual performance does not demonstrate gains in their overall conceptual understanding. Results suggest the need for instructional interventions fostering epistemological development of learners in order to facilitate their conceptual growth.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Sluis, C.
1980-09-01
The economic feasibility of plant tissue culture was demonstrated as applied to two plants: jojoba (Simmondsia chinensis) and Euphorbia spp. The gopher weed (Euphorbia lathyris) was selected as the species of Euphorbia to research due to the interest in this plant as a potential source of hydrocarbon-like compounds. High yield female selections of jojoba were chosen from native stands and were researched to determine the economic feasibility of mass producing these plants via a tissue culture micropropagation program. The female jojoba selection was successfully mass produced through tissue culture. Modifications in initiation techniques, as well as in multiplication media andmore » rooting parameters, were necessary to apply the tissue culture system, which had been developed for juvenile seedling tissue, to mature jojobas. Since prior attempts at transfer of tissue cultured plantlets were unsuccessful, transfer research was a major part of the project and has resulted in a system for transfer of rooted jojoba plantlets to soil. Euphorbia lathyris was successfully cultured using shoot tip cultures. Media and procedures were established for culture initiation, multiplication of shoots, callus induction and growth, and root initiation. Well-developed root systems were not attained and root initiation percentages should be increased if the system is to become commercially feasible.« less
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Unger, J B; Chen, X
1999-01-01
The increasing prevalence of adolescent smoking demonstrates the need to identify factors associated with early smoking initiation. Previous studies have shown that smoking by social network members and receptivity to pro-tobacco marketing are associated with smoking among adolescents. It is not clear, however, whether these variables also are associated with the age of smoking initiation. Using data from 10,030 California adolescents, this study identified significant correlates of age of smoking initiation using bivariate methods and a multivariate proportional hazards model. Age of smoking initiation was earlier among those adolescents whose friends, siblings, or parents were smokers, and among those adolescents who had a favorite tobacco advertisement, had received tobacco promotional items, or would be willing to use tobacco promotional items. Results suggest that the smoking behavior of social network members and pro-tobacco media influences are important determinants of age of smoking initiation. Because early smoking initiation is associated with higher levels of addiction in adulthood, tobacco control programs should attempt to counter these influences.
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GPIM AF-M315E Propulsion System
NASA Technical Reports Server (NTRS)
Spores, Ronald A.; Masse, Robert; Kimbrel, Scott; McLean, Chris
2014-01-01
The NASA Space Technology mission Directorate's (STMD) Green Propellant Infusion Mission (GPIM) Technology Demonstration Mission (TDM) will demonstrate an operational AF-M315E green propellant propulsion system. Aerojet-Rocketdyne is responsible for the development of the propulsion system payload. This paper statuses the propulsion system module development, including thruster design and system design; Initial test results for the 1N engineering model thruster are presented. The culmination of this program will be high-performance, green AF-M315E propulsion system technology at TRL 7+, with components demonstrated to TRL 9, ready for direct infusion to a wide range of applications for the space user community.
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Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.
Cencic, Regina; Carrier, Marilyn; Galicia-Vázquez, Gabriela; Bordeleau, Marie-Eve; Sukarieh, Rami; Bourdeau, Annie; Brem, Brigitte; Teodoro, Jose G; Greger, Harald; Tremblay, Michel L; Porco, John A; Pelletier, Jerry
2009-01-01
Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been shown to modulate the activity of eIF4A, the DEAD-box RNA helicase subunit of the eukaryotic initiation factor (eIF) 4F complex, a complex that stimulates ribosome recruitment during translation initiation. One flavagline, silvestrol, is capable of modulating chemosensitivity in a mechanism-based mouse model. Among a number of flavagline family members tested herein, we find that silvestrol is the more potent translation inhibitor among these. We find that silvestrol impairs the ribosome recruitment step of translation initiation by affecting the composition of the eukaryotic initiation factor (eIF) 4F complex. We show that silvestrol exhibits significant anticancer activity in human breast and prostate cancer xenograft models, and that this is associated with increased apoptosis, decreased proliferation, and inhibition of angiogenesis. We demonstrate that targeting translation by silvestrol results in preferential inhibition of weakly initiating mRNAs. Our results indicate that silvestrol is a potent anti-cancer compound in vivo that exerts its activity by affecting survival pathways as well as angiogenesis. We propose that silvestrol mediates its effects by preferentially inhibiting translation of malignancy-related mRNAs. Silvestrol appears to be well tolerated in animals.
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40 CFR 63.7114 - How do I demonstrate initial compliance with the emission limitations standard?
Code of Federal Regulations, 2012 CFR
2012-07-01
... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Lime Manufacturing Plants Testing and Initial Compliance Requirements § 63.7114 How do I demonstrate...
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Holmes, Brent; Lee, Jihye; Landon, Kenna A; Benavides-Serrato, Angelica; Bashir, Tariq; Jung, Michael E; Lichtenstein, Alan; Gera, Joseph
2016-07-01
Our previous work has demonstrated an intrinsic mRNA-specific protein synthesis salvage pathway operative in glioblastoma (GBM) tumor cells that is resistant to mechanistic target of rapamycin (mTOR) inhibitors. The activation of this internal ribosome entry site (IRES)-dependent mRNA translation initiation pathway results in continued translation of critical transcripts involved in cell cycle progression in the face of global eIF-4E-mediated translation inhibition. Recently we identified compound 11 (C11), a small molecule capable of inhibiting c-MYC IRES translation as a consequence of blocking the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. Here we demonstrate that C11 also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties when combined with the mechanistic target of rapamycin kinase inhibitor PP242. The structure-activity relationship of C11 was investigated and resulted in the identification of IRES-J007, which displayed improved IRES-dependent initiation blockade and synergistic anti-GBM effects with PP242. Mechanistic studies with C11 and IRES-J007 revealed binding of the inhibitors within the UP1 fragment of heterogeneous nuclear ribonucleoprotein A1, and docking analysis suggested a small pocket within close proximity to RRM2 as the potential binding site. We further demonstrate that co-therapy with IRES-J007 and PP242 significantly reduces tumor growth of GBM xenografts in mice and that combined inhibitor treatments markedly reduce the mRNA translational state of cyclin D1 and c-MYC transcripts in these tumors. These data support the combined use of IRES-J007 and PP242 to achieve synergistic antitumor responses in GBM. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.
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Numerical simulations of the process of multiple shock-flame interactions
NASA Astrophysics Data System (ADS)
Jiang, Hua; Dong, Gang; chen, Xiao; Wu, Jin-Tao
2016-08-01
Based on a weighted essentially nonoscillatory scheme, the multiple interactions of a flame interface with an incident shock wave and its reshock waves are numerically simulated by solving the compressible reactive Navier-Stokes equations with a single-step Arrhenius chemical reaction. The two-dimensional sinusoidally perturbed premixed flames with different initial perturbed amplitudes are used to investigate the effect of the initial perturbation on the flame evolutions. The results show that the development of the flame interface is directly affected by the initial perturbed amplitudes before the passages of reshock waves, and the perturbation development is mainly controlled by the Richtmyer-Meshkov instability (RMI). After the successive impacts of multiple reshock waves, the chemical reaction accelerates the consumption of reactants and leads to a gradual disappearance of the initial perturbed information. The perturbation developments in frozen flows with the same initial interface as those in reactive flows are also demonstrated. Comparisons of results between the reactive and frozen flows show that a chemical reaction changes the perturbation pattern of the flame interface by decreasing the density gradient, thereby weakening the baroclinic torque in the flame mixing region, and therefore plays a dominant role after the passage of reshock waves.
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Application of Interface Technology in Progressive Failure Analysis of Composite Panels
NASA Technical Reports Server (NTRS)
Sleight, D. W.; Lotts, C. G.
2002-01-01
A progressive failure analysis capability using interface technology is presented. The capability has been implemented in the COMET-AR finite element analysis code developed at the NASA Langley Research Center and is demonstrated on composite panels. The composite panels are analyzed for damage initiation and propagation from initial loading to final failure using a progressive failure analysis capability that includes both geometric and material nonlinearities. Progressive failure analyses are performed on conventional models and interface technology models of the composite panels. Analytical results and the computational effort of the analyses are compared for the conventional models and interface technology models. The analytical results predicted with the interface technology models are in good correlation with the analytical results using the conventional models, while significantly reducing the computational effort.
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NASA Astrophysics Data System (ADS)
Tian, Lei; Waller, Laura
2017-05-01
Microscope lenses can have either large field of view (FOV) or high resolution, not both. Computational microscopy based on illumination coding circumvents this limit by fusing images from different illumination angles using nonlinear optimization algorithms. The result is a Gigapixel-scale image having both wide FOV and high resolution. We demonstrate an experimentally robust reconstruction algorithm based on a 2nd order quasi-Newton's method, combined with a novel phase initialization scheme. To further extend the Gigapixel imaging capability to 3D, we develop a reconstruction method to process the 4D light field measurements from sequential illumination scanning. The algorithm is based on a 'multislice' forward model that incorporates both 3D phase and diffraction effects, as well as multiple forward scatterings. To solve the inverse problem, an iterative update procedure that combines both phase retrieval and 'error back-propagation' is developed. To avoid local minimum solutions, we further develop a novel physical model-based initialization technique that accounts for both the geometric-optic and 1st order phase effects. The result is robust reconstructions of Gigapixel 3D phase images having both wide FOV and super resolution in all three dimensions. Experimental results from an LED array microscope were demonstrated.
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Schnapp, A; Clos, J; Hädelt, W; Schreck, R; Cvekl, A; Grummt, I
1990-03-25
The murine ribosomal gene promoter contains two cis-acting control elements which operate in concert to promote efficient and accurate transcription initiation by RNA polymerase I. The start site proximal core element which is indispensable for promoter recognition by RNA polymerase I (pol I) encompasses sequences from position -39 to -1. An upstream control element (UCE) which is located between nucleotides -142 and -112 stimulates the efficiency of transcription initiation both in vivo and in vitro. Here we report the isolation and functional characterization of a specific rDNA binding protein, the transcription initiation factor TIF-IB, which specifically interacts with the core region of the mouse ribosomal RNA gene promoter. Highly purified TIF-IB complements transcriptional activity in the presence of two other essential initiation factors TIF-IA and TIF-IC. We demonstrate that the binding efficiency of purified TIF-IB to the core promoter is strongly enhanced by the presence in cis of the UCE. This positive effect of upstream sequences on TIF-IB binding is observed throughout the purification procedure suggesting that the synergistic action of the two distant promoter elements is not mediated by a protein different from TIF-IB. Increasing the distance between both control elements still facilitates stable factor binding but eliminates transcriptional activation. The results demonstrate that TIF-IB binding to the rDNA promoter is an essential early step in the assembly of a functional transcription initiation complex. The subsequent interaction of TIF-IB with other auxiliary transcription initiation factors, however, requires the correct spacing between the UCE and the core promoter element.
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Aircraft accident investigation: the decision-making in initial action scenario.
Barreto, Marcia M; Ribeiro, Selma L O
2012-01-01
In the complex aeronautical environment, the efforts in terms of operational safety involve the adoption of proactive and reactive measures. The process of investigation begins right after the occurrence of the aeronautical accident, through the initial action. Thus, it is in the crisis scenario, that the person responsible for the initial action makes decisions and gathers the necessary information for the subsequent phases of the investigation process. Within this scenario, which is a natural environment, researches have shown the fragility of rational models of decision making. The theoretical perspective of naturalistic decision making constitutes a breakthrough in the understanding of decision problems demanded by real world. The proposal of this study was to verify if the initial action, after the occurrence of an accident, and the decision-making strategies, used by the investigators responsible for this activity, are characteristic of the naturalistic decision making theoretical approach. To attend the proposed objective a descriptive research was undertaken with a sample of professionals that work in this activity. The data collected through individual interviews were analyzed and the results demonstrated that the initial action environment, which includes restricted time, dynamic conditions, the presence of multiple actors, stress and insufficient information is characteristic of the naturalistic decision making. They also demonstrated that, when the investigators make their decisions, they use their experience and the mental simulation, intuition, improvisation, metaphors and analogues cases, as strategies, all of them related to the naturalistic approach of decision making, in order to satisfy the needs of the situation and reach the objectives of the initial action in the accident scenario.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Hansen, Ryan H.; Timm, Andrea C.; Timm, Collin M.
The structure, function and evolving composition of microbial communities is deeply influenced by the physical and chemical architecture of the local microenvironment. The complexity of this parameter space in naturally occurring systems has made a clear understanding of the key drivers of community development elusive. Here, we examine the role of spatial confinement on community development using a microwell platform that allows for assembly and monitoring of unique microbial communities en masse. This platform was designed to contain microwells with varied size features in order to mimic various levels of spatial confinement found in natural systems. Microbial populations assembled inmore » wells with incrementally smaller size features showed increasingly larger variations in inoculum levels. By exploiting this size dependence, large wells were used to assemble homogenous initial populations of Pseudomonas aeruginosa, allowing for reproducible, directed growth trajectories. In contrast, smaller wells were used to assemble a heterogeneous range of initial populations, resulting in a variety of growth and decay trajectories. This allowed for parallel screening of single member communities across different levels of confinement to identify initial conditions in which P. aeruginosa colonies have dramatically higher probabilities of survival. These results demonstrate a unique approach for manipulating the distribution of initial microbial populations assembled into controlled microenvironments to rapidly identify population and environmental parameters conducive or inhibitive to growth. Additionally, multi-member community assembly was characterized to demonstrate the power of this platform for studying the role of member abundance on microbial competition, mutualism and community succession.« less
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Hansen, Ryan H.; Timm, Andrea C.; Timm, Collin M.; ...
2016-05-06
The structure, function and evolving composition of microbial communities is deeply influenced by the physical and chemical architecture of the local microenvironment. The complexity of this parameter space in naturally occurring systems has made a clear understanding of the key drivers of community development elusive. Here, we examine the role of spatial confinement on community development using a microwell platform that allows for assembly and monitoring of unique microbial communities en masse. This platform was designed to contain microwells with varied size features in order to mimic various levels of spatial confinement found in natural systems. Microbial populations assembled inmore » wells with incrementally smaller size features showed increasingly larger variations in inoculum levels. By exploiting this size dependence, large wells were used to assemble homogenous initial populations of Pseudomonas aeruginosa, allowing for reproducible, directed growth trajectories. In contrast, smaller wells were used to assemble a heterogeneous range of initial populations, resulting in a variety of growth and decay trajectories. This allowed for parallel screening of single member communities across different levels of confinement to identify initial conditions in which P. aeruginosa colonies have dramatically higher probabilities of survival. These results demonstrate a unique approach for manipulating the distribution of initial microbial populations assembled into controlled microenvironments to rapidly identify population and environmental parameters conducive or inhibitive to growth. Additionally, multi-member community assembly was characterized to demonstrate the power of this platform for studying the role of member abundance on microbial competition, mutualism and community succession.« less
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NASA Astrophysics Data System (ADS)
Zhou, Feifan; Yamaguchi, Munehiko; Qin, Xiaohao
2016-07-01
This paper investigates the possible sources of errors associated with tropical cyclone (TC) tracks forecasted using the Global/Regional Assimilation and Prediction System (GRAPES). The GRAPES forecasts were made for 16 landfalling TCs in the western North Pacific basin during the 2008 and 2009 seasons, with a forecast length of 72 hours, and using the default initial conditions ("initials", hereafter), which are from the NCEP-FNL dataset, as well as ECMWF initials. The forecasts are compared with ECMWF forecasts. The results show that in most TCs, the GRAPES forecasts are improved when using the ECMWF initials compared with the default initials. Compared with the ECMWF initials, the default initials produce lower intensity TCs and a lower intensity subtropical high, but a higher intensity South Asia high and monsoon trough, as well as a higher temperature but lower specific humidity at the TC center. Replacement of the geopotential height and wind fields with the ECMWF initials in and around the TC center at the initial time was found to be the most efficient way to improve the forecasts. In addition, TCs that showed the greatest improvement in forecast accuracy usually had the largest initial uncertainties in TC intensity and were usually in the intensifying phase. The results demonstrate the importance of the initial intensity for TC track forecasts made using GRAPES, and indicate the model is better in describing the intensifying phase than the decaying phase of TCs. Finally, the limit of the improvement indicates that the model error associated with GRAPES forecasts may be the main cause of poor forecasts of landfalling TCs. Thus, further examinations of the model errors are required.
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Non-Small Cell Lung Cancer Cells Expressing CD44 Are Enriched for Stem Cell-Like Properties
Leung, Elaine Lai-Han; Fiscus, Ronald R.; Tung, James W.; Tin, Vicky Pui-Chi; Cheng, Lik Cheung; Sihoe, Alan Dart-Loon; Fink, Louis M.; Ma, Yupo; Wong, Maria Pik
2010-01-01
Background The cancer stem cell theory hypothesizes that cancers are perpetuated by cancer stem cells (CSC) or tumor initiating cells (TIC) possessing self-renewal and other stem cell-like properties while differentiated non-stem/initiating cells have a finite life span. To investigate whether the hypothesis is applicable to lung cancer, identification of lung CSC and demonstration of these capacities is essential. Methodology/Principal Finding The expression profiles of five stem cell markers (CD34, CD44, CD133, BMI1 and OCT4) were screened by flow cytometry in 10 lung cancer cell lines. CD44 was further investigated by testing for in vitro and in vivo tumorigenecity. Formation of spheroid bodies and in vivo tumor initiation ability were demonstrated in CD44+ cells of 4 cell lines. Serial in vivo tumor transplantability in nude mice was demonstrated using H1299 cell line. The primary xenografts initiated from CD44+ cells consisted of mixed CD44+ and CD44− cells in similar ratio as the parental H1299 cell line, supporting in vivo differentiation. Semi-quantitative Real-Time PCR (RT-PCR) showed that both freshly sorted CD44+ and CD44+ cells derived from CD44+-initiated tumors expressed the pluripotency genes OCT4/POU5F1, NANOG, SOX2. These stemness markers were not expressed by CD44− cells. Furthermore, freshly sorted CD44+ cells were more resistant to cisplatin treatment with lower apoptosis levels than CD44− cells. Immunohistochemical analysis of 141 resected non-small cell lung cancers showed tumor cell expression of CD44 in 50.4% of tumors while no CD34, and CD133 expression was observed in tumor cells. CD44 expression was associated with squamous cell carcinoma but unexpectedly, a longer survival was observed in CD44-expressing adenocarcinomas. Conclusion/Significance Overall, our results demonstrated that stem cell-like properties are enriched in CD44-expressing subpopulations of some lung cancer cell lines. Further investigation is required to clarify the role of CD44 in tumor cell renewal and cancer propagation in the in vivo environment. PMID:21124918
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Guo, Dongshu; Zhang, Jinzhe; Wang, Xinlei; Han, Xiang; Wei, Baoye; Wang, Jianqiao; Li, Boxun; Yu, Hao; Huang, Qingpei; Gu, Hongya; Qu, Li-Jia; Qin, Genji
2015-11-01
Plant shoot branching is pivotal for developmental plasticity and crop yield. The formation of branch meristems is regulated by several key transcription factors including REGULATOR OF AXILLARY MERISTEMS1 (RAX1), RAX2, and RAX3. However, the regulatory network of shoot branching is still largely unknown. Here, we report the identification of EXCESSIVE BRANCHES1 (EXB1), which affects axillary meristem (AM) initiation and bud activity. Overexpression of EXB1 in the gain-of-function mutant exb1-D leads to severe bushy and dwarf phenotypes, which result from excessive AM initiation and elevated bud activities. EXB1 encodes the WRKY transcription factor WRKY71, which has demonstrated transactivation activities. Disruption of WRKY71/EXB1 by chimeric repressor silencing technology leads to fewer branches, indicating that EXB1 plays important roles in the control of shoot branching. We demonstrate that EXB1 controls AM initiation by positively regulating the transcription of RAX1, RAX2, and RAX3. Disruption of the RAX genes partially rescues the branching phenotype caused by EXB1 overexpression. We further show that EXB1 also regulates auxin homeostasis in control of shoot branching. Our data demonstrate that EXB1 plays pivotal roles in shoot branching by regulating both transcription of RAX genes and auxin pathways. © 2015 American Society of Plant Biologists. All rights reserved.
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Guo, Dongshu; Zhang, Jinzhe; Wang, Xinlei; Han, Xiang; Wei, Baoye; Yu, Hao; Huang, Qingpei
2015-01-01
Plant shoot branching is pivotal for developmental plasticity and crop yield. The formation of branch meristems is regulated by several key transcription factors including REGULATOR OF AXILLARY MERISTEMS1 (RAX1), RAX2, and RAX3. However, the regulatory network of shoot branching is still largely unknown. Here, we report the identification of EXCESSIVE BRANCHES1 (EXB1), which affects axillary meristem (AM) initiation and bud activity. Overexpression of EXB1 in the gain-of-function mutant exb1-D leads to severe bushy and dwarf phenotypes, which result from excessive AM initiation and elevated bud activities. EXB1 encodes the WRKY transcription factor WRKY71, which has demonstrated transactivation activities. Disruption of WRKY71/EXB1 by chimeric repressor silencing technology leads to fewer branches, indicating that EXB1 plays important roles in the control of shoot branching. We demonstrate that EXB1 controls AM initiation by positively regulating the transcription of RAX1, RAX2, and RAX3. Disruption of the RAX genes partially rescues the branching phenotype caused by EXB1 overexpression. We further show that EXB1 also regulates auxin homeostasis in control of shoot branching. Our data demonstrate that EXB1 plays pivotal roles in shoot branching by regulating both transcription of RAX genes and auxin pathways. PMID:26578700
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Summary of results from the Tandem Mirror Experiment (TMX)
DOE Office of Scientific and Technical Information (OSTI.GOV)
Simonen, T.C.
1981-02-26
This report summarizes results from the successful experimental operation of the Tandem Mirror Experiment (TMX) over the period October 1978 through September 1980. The experimental program, summarized by the DOE milestones given in Table 1-1, had three basic phases: (1) an 8-month checkout period, October 1978 through May 1979; (2) a 6-month initial period of operation, June through November 1979, during which the basic principles of the tandem configuration were demonstrated (i.e., plasma confinement was improved over that of a single-cell mirror); and (3) a 10-month period, December 1979 through September 1980, during which the initial TMX results were corroboratedmore » by additional diagnostic measurements and many detailed physics investigations were carried out. This report summarizes the early results, presents results of recent data analysis, and outlines areas of ongoing research and data analysis which will be reported in future journal publications.« less
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Henzlova, Daniela; Menlove, Howard Olsen; Rael, Carlos D.; ...
2015-10-09
Our paper presents results of the first experimental demonstration of the Californium Interrogation Prompt Neutron (CIPN) instrument developed within a multi-year effort launched by the Next Generation Safeguards Initiative Spent Fuel Project of the United States Department of Energy. The goals of this project focused on developing viable non-destructive assay techniques with capabilities to improve an independent verification of spent fuel assembly characteristics. For this purpose, the CIPN instrument combines active and passive neutron interrogation, along with passive gamma-ray measurements, to provide three independent observables. We describe the initial feasibility demonstration of the CIPN instrument, which involved measurements of fourmore » pressurized-water-reactor spent fuel assemblies with different levels of burnup and two initial enrichments. The measurements were performed at the Post-Irradiation Examination Facility at the Korea Atomic Energy Institute in the Republic of Korea. The key aim of the demonstration was to evaluate CIPN instrument performance under realistic deployment conditions, with the focus on a detailed assessment of systematic uncertainties that are best evaluated experimentally. The measurements revealed good positioning reproducibility, as well as a high degree of insensitivity of the CIPN instrument's response to irregularities in a radial burnup profile. Systematic uncertainty of individual CIPN instrument signals due to assembly rotation was found to be <4.5%, even for assemblies with fairly extreme gradients in the radial burnup profile. Lastly, these features suggest that the CIPN instrument is capable of providing a good representation of assembly average characteristics, independent of assembly orientation in the instrument.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Henzlova, Daniela; Menlove, Howard Olsen; Rael, Carlos D.
Our paper presents results of the first experimental demonstration of the Californium Interrogation Prompt Neutron (CIPN) instrument developed within a multi-year effort launched by the Next Generation Safeguards Initiative Spent Fuel Project of the United States Department of Energy. The goals of this project focused on developing viable non-destructive assay techniques with capabilities to improve an independent verification of spent fuel assembly characteristics. For this purpose, the CIPN instrument combines active and passive neutron interrogation, along with passive gamma-ray measurements, to provide three independent observables. We describe the initial feasibility demonstration of the CIPN instrument, which involved measurements of fourmore » pressurized-water-reactor spent fuel assemblies with different levels of burnup and two initial enrichments. The measurements were performed at the Post-Irradiation Examination Facility at the Korea Atomic Energy Institute in the Republic of Korea. The key aim of the demonstration was to evaluate CIPN instrument performance under realistic deployment conditions, with the focus on a detailed assessment of systematic uncertainties that are best evaluated experimentally. The measurements revealed good positioning reproducibility, as well as a high degree of insensitivity of the CIPN instrument's response to irregularities in a radial burnup profile. Systematic uncertainty of individual CIPN instrument signals due to assembly rotation was found to be <4.5%, even for assemblies with fairly extreme gradients in the radial burnup profile. Lastly, these features suggest that the CIPN instrument is capable of providing a good representation of assembly average characteristics, independent of assembly orientation in the instrument.« less
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Tao, Guohua; Miller, William H
2011-07-14
An efficient time-dependent importance sampling method is developed for the Monte Carlo calculation of time correlation functions via the initial value representation (IVR) of semiclassical (SC) theory. A prefactor-free time-dependent sampling function weights the importance of a trajectory based on the magnitude of its contribution to the time correlation function, and global trial moves are used to facilitate the efficient sampling the phase space of initial conditions. The method can be generally applied to sampling rare events efficiently while avoiding being trapped in a local region of the phase space. Results presented in the paper for two system-bath models demonstrate the efficiency of this new importance sampling method for full SC-IVR calculations.
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Stewart, Claire Elizabeth; Sage, Emma Louise Maitland; Reynolds, Peter
2016-07-01
We describe a quality improvement initiative conducted in a medium-sized district general hospital with a neonatal intensive care unit, which involved working with the multidisciplinary team to create a 'Baby Friendly' neonatal hypoglycaemia pathway with implementation of dextrose gel as a first-line treatment. As a result of the project, formula supplementation rates and admissions for transitional hypoglycaemia were reduced and breastfeeding rates at 3 months improved. This initiative demonstrates that evidence-based guidelines with multidisciplinary team input can improve standards of care. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
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NASA Astrophysics Data System (ADS)
Gupta, Ankur; Balomajumder, Chandrajit
2017-12-01
In this study, simultaneous removal of Cr(VI) and phenol from binary solution was carried out using Fe-treated tea waste biomass. The effect of process parameters such as adsorbent dose, pH, initial concentration of Cr(VI) (mg/L), and initial concentration of phenol (mg/L) was optimized. The analysis of variance of the quadratic model demonstrates that the experimental results are in good agreement with the predicted values. Based on experimental design at an initial concentration of 55 mg/L of Cr(VI), 27.50 mg/L of phenol, pH 2.0, 15 g/L adsorbent dose, 99.99% removal of Cr(VI), and phenol was achieved.
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NASA Astrophysics Data System (ADS)
Auborn, K. J.; Little, R. D.; Platt, T. H. K.; Vaccariello, M. A.; Schildkraut, C. L.
1994-07-01
We have examined the structures of replication intermediates from the human papillomavirus type 11 genome in DNA extracted from papilloma lesions (laryngeal papillomas). The sites of replication initiation and termination utilized in vivo were mapped by using neutral/neutral and neutral/alkaline two-dimensional agarose gel electrophoresis methods. Initiation of replication was detected in or very close to the upstream regulatory region (URR; the noncoding, regulatory sequences upstream of the open reading frames in the papillomavirus genome). We also show that replication forks proceed bidirectionally from the origin and converge 180circ opposite the URR. These results demonstrate the feasibility of analysis of replication of viral genomes directly from infected tissue.
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Zahed, Mohammad Ali; Aziz, Hamidi Abdul; Isa, Mohamed Hasnain; Mohajeri, Leila
2010-04-01
The effects of initial oil concentration and the Corexit 9500 dispersant on the rate of bioremediation of petroleum hydrocarbons were investigated with a series of ex-situ seawater samples. With initial oil concentrations of 100, 500, 1,000 and 2,000 mg/L, removal of total petroleum hydrocarbons (TPHs) with dispersant were 67.3%, 62.5%, 56.5% and 44.7%, respectively, and were 64.2%, 55.7%, 48.8% and 37.6% without dispersant. The results clearly indicate that the presence of dispersant enhanced crude oil biodegradation. Lower concentrations of crude oil demonstrated more efficient hydrocarbon removal. Based on these findings, bioremediation is not recommended for crude oil concentrations of 2,000 mg/L or higher.
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Electric utility acid fuel cell stack technology advancement
NASA Astrophysics Data System (ADS)
Congdon, J. V.; Goller, G. J.; Greising, G. J.; Obrien, J. J.; Randall, S. A.; Sandelli, G. J.; Breault, R. D.; Austin, G. W.; Bopse, S.; Coykendall, R. D.
1984-11-01
The principal effort under this program was directed at the fuel cell stack technology required to accomplish the initial feasibility demonstrations of increased cell stack operating pressures and temperatures, increased cell active area, incorporation of the ribbed substrate cell configuration at the bove conditions, and the introduction of higher performance electrocatalysts. The program results were successful with the primary accomplishments being: (1) fabrication of 10 sq ft ribbed substrate, cell components including higher performing electrocatalysts; (2) assembly of a 10 sq ft, 30-cell short stack; and (3) initial test of this stack at 120 psia and 405 F. These accomplishments demonstrate the feasibility of fabricating and handling large area cells using materials and processes that are oriented to low cost manufacture. An additional accomplishment under the program was the testing of two 3.7 sq ft short stacks at 12 psia/405 F to 5400 and 4500 hours respectively. These tests demonstrate the durability of the components and the cell stack configuration to a nominal 5000 hours at the higher pressure and temperature condition planned for the next electric utility power plant.
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Carbon source and energy harvesting optimization in solid anolyte microbial fuel cells
NASA Astrophysics Data System (ADS)
Adekunle, Ademola; Raghavan, Vijaya; Tartakovsky, Boris
2017-07-01
This work investigates the application of a solid anolyte microbial fuel cell (saMFC) as a long-lasting source of electricity for powering electronic devices. Broadly available biodegradable materials such as humus, cattle manure, peat moss, and sawdust are evaluated as solid anolytes. The initial comparison shows significantly higher power production in the saMFC operated using humus as compared to other solid anolytes. At the same time, power production in the humus-based saMFC is found to decline after about 40 days of operation, while the sawdust MFC demonstrates stable performance over the test period. Following this initial comparison, a combined humus - sawdust anolyte is developed to increase saMFC life span. The optimized saMFC demonstrates stable power production for over nine months. Furthermore, power production in the saMFC is maximized by using an intermittent connection to an electrical load (on/off operation) and optimizing the connection/disconnection times. These results demonstrate the feasibility of utilizing solid anolytes for developing inexpensive and long-lasting biobatteries operated on renewable carbon sources.
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Electric utility acid fuel cell stack technology advancement
NASA Technical Reports Server (NTRS)
Congdon, J. V.; Goller, G. J.; Greising, G. J.; Obrien, J. J.; Randall, S. A.; Sandelli, G. J.; Breault, R. D.; Austin, G. W.; Bopse, S.; Coykendall, R. D.
1984-01-01
The principal effort under this program was directed at the fuel cell stack technology required to accomplish the initial feasibility demonstrations of increased cell stack operating pressures and temperatures, increased cell active area, incorporation of the ribbed substrate cell configuration at the bove conditions, and the introduction of higher performance electrocatalysts. The program results were successful with the primary accomplishments being: (1) fabrication of 10 sq ft ribbed substrate, cell components including higher performing electrocatalysts; (2) assembly of a 10 sq ft, 30-cell short stack; and (3) initial test of this stack at 120 psia and 405 F. These accomplishments demonstrate the feasibility of fabricating and handling large area cells using materials and processes that are oriented to low cost manufacture. An additional accomplishment under the program was the testing of two 3.7 sq ft short stacks at 12 psia/405 F to 5400 and 4500 hours respectively. These tests demonstrate the durability of the components and the cell stack configuration to a nominal 5000 hours at the higher pressure and temperature condition planned for the next electric utility power plant.
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Planning, Implementing, and Documenting an Innovative Statewide Occupational Initiative.
ERIC Educational Resources Information Center
Floyd, Jerald D.
During an 18-month demonstration period, the Illinois Occupational Program Initiative (IOPI), funded through the state's Division of Alcoholism, demonstrated the feasibility of funding individual contractors to create and market employee assistance programs (EAPs) to representatives of industry and labor. Cost estimates for the EAPs were to cover…
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40 CFR 63.4741 - How do I demonstrate initial compliance with the emission limitations?
Code of Federal Regulations, 2011 CFR
2011-07-01
... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for Hazardous Air Pollutants: Surface Coating of... practice standards required in §§ 63.4692 and 63.4693, respectively. To demonstrate initial compliance with...
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ERIC Educational Resources Information Center
Mayton, Michael R.; Carter, Stacy L.; Zhang, Jie; Wheeler, John J.
2014-01-01
The behaviors frequently displayed by students with autism can place them at risk for overly reactive behavior interventions with unwanted side effects. The current study examined the level of intrusiveness of behavioral treatments developed for 198 students with disabilities from 13 different states. Results demonstrated that students diagnosed…
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Report #15-P-0198, July 16, 2015. EPA does not know the benefits realized from its efforts to promote siting renewable energy on contaminated lands. As a result, the agency is unable to demonstrate benefits realized for the $4 million it stated it has inve
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Myer, Michael; Goettel, Russell T.
2010-06-29
A report describing the process and results of replacing existing parking lot lighting, looking at a LED option with occupancy sensors, and conventional alternates. Criteria include payback, light levels, occupant satisfaction. This report is Phase I of II. Phase I deals with initial installation.
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Empirical Evidence in Support of a Research-Informed Water Conservation Education Program
ERIC Educational Resources Information Center
Thompson, Ruthanne; Serna, Victoria Faubion
2016-01-01
Based on results from a 2008 research study of regional citizen knowledge concerning watershed issues, a water conservation education program was designed and implemented. Findings from the initial study demonstrated program success as evidenced by knowledge gain and willingness to "commit" to water saving behaviors in 94% of students. A…
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29 CFR 1910.1018 - Inorganic arsenic.
Code of Federal Regulations, 2011 CFR
2011-07-01
...-anterior chest x-ray; (B) A nasal and skin examination; and (C) Other examinations which the physician... results or references to that information; (C) The initial X-ray; (D) The X-rays for the most recent 5 years; and (E) Any X-rays with a demonstrated abnormality and all subsequent X-rays; (iv) The employer...
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Transcriptomic and field evaluation of apple trees overexpressing a peach CBF gene
USDA-ARS?s Scientific Manuscript database
The role of CBF genes in cold response and acclimation has been well documented in both herbaceous and woody plants. Our initial research demonstrated that overexpression of a peach CBF gene (PpCBF1) in ‘M.26’ apple increases freezing tolerance of non-acclimated plants and unexpectedly also results...
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ERIC Educational Resources Information Center
Donohue, Brad; Azrin, Nathan H.; Lawson, Heather; Friedlander, Josh; Teichner, Gordon; Rindsberg, Jeff
1998-01-01
Demonstrates a method of improving first session attendance in a population of conduct-disordered and substance-abusing adolescents. Results indicate that an intensive intervention involving the youth and parent was more effective in improving session attendance than a less intensive intervention that excluded the youth's involvement. Discusses…
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Re-Os isotopic systematics in chromitites from the Stillwater Complex, Montana, USA
NASA Astrophysics Data System (ADS)
Marcantonio, Franco; Zindler, Alan; Reisberg, Laurie; Mathez, E. A.
1993-08-01
New Re-Os isotopic data on chromitites of the Stillwater Complex demonstrate isotopic equilibrium between cumulate chromite and whole rock. Initial osmium isotopic ratios for the chromitites, chosen for their freshness, are consistent with derivation from a mantle-derived magma that suffered little or no interaction with the continental crust prior to crystallization. Molybdenite, separated from a sample of the G-chromitite, yields a Re-Os age of 2740 Ma, indistinguishable from the age of the intrusion. The presence of molybdenite documents rhenium, and probably osmium, mobilization by hydrothermal fluids that permeated the intrusion shortly after crystallization. Initial osmium isotopic variability observed in chromitites and other rocks from the Stillwater Complex could result from interaction with these fluids. In this context, there is no compelling reason to call on assimilation of crust by mantle-derived magma to explain the osmium or neodymium isotopic variability. Although osmium isotopic systematics have been affected by hydrothermal processes, Re-Os results demonstrate that more than 95 percent of the osmium, and by inference other PGEs in the Stillwater Complex, derive from the mantle.
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Airborne Turbulence Detection and Warning ACLAIM Flight Test Results
NASA Technical Reports Server (NTRS)
Hannon, Stephen M.; Bagley, Hal R.; Soreide, Dave C.; Bowdle, David A.; Bogue, Rodney K.; Ehernberger, L. Jack
1999-01-01
The Airborne Coherent Lidar for Advanced Inflight Measurements (ACLAIM) is a NASA/Dryden-lead program to develop and demonstrate a 2 micrometers pulsed Doppler lidar for airborne look-ahead turbulence detection and warning. Advanced warning of approaching turbulence can significantly reduce injuries to passengers and crew aboard commercial airliners. The ACLAIM instrument is a key asset to the ongoing Turbulence component of NASA's Aviation Safety Program, aimed at reducing the accident rate aboard commercial airliners by a factor of five over the next ten years and by a factor of ten over the next twenty years. As well, the advanced turbulence warning capability can prevent "unstarts" in the inlet of supersonic aircraft engines by alerting the flight control computer which then adjusts the engine to operate in a less fuel efficient, and more turbulence tolerant, mode. Initial flight tests of the ACLAIM were completed in March and April of 1998. This paper and presentation gives results from these initial flights, with validated demonstration of Doppler lidar wind turbulence detection several kilometers ahead of the aircraft.
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Initial results from a cryogenic proton irradiation of a p-channel CCD
NASA Astrophysics Data System (ADS)
Gow, J. P. D.; Wood, D.; Burt, D.; Hall, D. J.; Dryer, B.; Holland, A. D.; Murray, N. J.
2015-08-01
The displacement damage hardness that can be achieved using p-channel charge coupled devices (CCD) was originally demonstrated in 1997 and since then a number of other studies have demonstrated an improved tolerance to radiationinduced CTI when compared to n-channel CCDs. A number of recent studies have also shown that the temperature history of the device after the irradiation impacts the performance of the detector, linked to the mobility of defects at different temperatures. This study describes the initial results from an e2v technologies p-channel CCD204 irradiated at 153 K with a 10 MeV equivalent proton fluences of 1.24×109 and 1.24×1011 protons.cm-2. The number of defects identified using trap pumping, dark current and cosmetic quality immediately after irradiation and over a period of 150 hours after the irradiation with the device held at 153 K and then after different periods of time at room temperature are described. The device also exhibited a flatband voltage shift of around 30 mV per krad, determined by the reduction in full well capacity.
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Effects of Psychological Attention on Pronoun Comprehension
Arnold, Jennifer E.; Lao, Shin-Yi C.
2015-01-01
Pronoun comprehension is facilitated for referents that are focused in the discourse context. Discourse focus has been described as a function of attention, especially shared attention, but few studies have explicitly tested this idea. Two experiments used an exogenous capture cue paradigm to demonstrate that listeners’ visual attention at the onset of a story influences their preferences during pronoun resolution later in the story. In both experiments trial-initial attention modulated listeners’ transitory biases while considering referents for the pronoun, whether it was in response to the capture cue or not. These biases even had a small influence on listeners’ final interpretation of the pronoun. These results provide independently-motivated evidence that the listener’s attention influences the on-line processes of pronoun comprehension. Trial-initial attentional shifts were made on the basis of non-shared, private information, demonstrating that attentional effects on pronoun comprehension are not restricted to shared attention among interlocutors. PMID:26191533
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Nagel, Thomas; Kelly, Daniel J
2010-11-01
Constitutive models facilitate investigation into load bearing mechanisms of biological tissues and may aid attempts to engineer tissue replacements. In soft tissue models, a commonly made assumption is that collagen fibers can only bear tensile loads. Previous computational studies have demonstrated that radially aligned fibers stiffen a material in unconfined compression most by limiting lateral expansion while vertically aligned fibers buckle under the compressive loads. In this short communication, we show that in conjunction with swelling, these intuitive statements can be violated at small strains. Under such conditions, a tissue with fibers aligned parallel to the direction of load initially provides the greatest resistance to compression. The results are further put into the context of a Benninghoff architecture for articular cartilage. The predictions of this computational study demonstrate the effects of varying fiber orientations and an initial tare strain on the apparent material parameters obtained from unconfined compression tests of charged tissues.
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Chromosomal instability affects the tumorigenicity of glioblastoma tumor-initiating cells
Godek, Kristina M.; Venere, Monica; Wu, Quilian; Mills, Kevin D.; Hickey, William F.; Rich, Jeremy N.; Compton, Duane A.
2016-01-01
Tumors are dynamic organs that evolve during disease progression with genetic, epigenetic, and environmental differences among tumor cells serving as the foundation for selection and evolution in tumors. Tumor-initiating cells (TICs) that are responsible for tumorigenesis are a source of functional cellular heterogeneity while chromosomal instability (CIN) is a source of karyotypic genetic diversity. However, the extent that CIN contributes to TIC genetic diversity and its relationship to TIC function remains unclear. Here we demonstrate that glioblastoma TICs display chromosomal instability with lagging chromosomes at anaphase and extensive non-clonal chromosome copy number variations. Elevating the basal chromosome mis-segregation rate in TICs both decreases proliferation and the stem-like phenotype of TICs in vitro. Consequently tumor formation is abolished in an orthotopic mouse model. These results demonstrate that TICs generate genetic heterogeneity within tumors but that TIC function is impaired if the rate of genetic change is elevated above a tolerable threshold. PMID:27001151
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Richardson, J Don; Elhai, Jon D; Sarreen, Jitender
2011-09-01
Military-related posttraumatic stress disorder (PTSD) is a significant psychiatric condition associated with severe psychosocial dysfunction. This study examined the predictors of treatment outcome in a group of veterans with military-related PTSD. Participants were 102 Canadian combat and peacekeeping veterans who received treatment at a specialized outpatient clinic for veterans with psychiatric disorders resulting from military operation. Analysis demonstrated a significant decrease in PTSD severity during the 1-year period (Yuan-Bentler χ [86, N = 99] = 282.45, p < 0.001). We did not find chronicity, alcohol use, and anxiety or depression severity as significant predictors for PTSD symptom decline. However, initial depression significantly predicted anxiety symptom decline, and initial anxiety predicted depression symptom decline. This study demonstrated that, despite considerable comorbidity, significant treatment gains, including remission of PTSD, can be achieved in an outpatient setting in veterans with chronic military-related PTSD.
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Neuroanatomic organization of sound memory in humans.
Kraut, Michael A; Pitcock, Jeffery A; Calhoun, Vince; Li, Juan; Freeman, Thomas; Hart, John
2006-11-01
The neural interface between sensory perception and memory is a central issue in neuroscience, particularly initial memory organization following perceptual analyses. We used functional magnetic resonance imaging to identify anatomic regions extracting initial auditory semantic memory information related to environmental sounds. Two distinct anatomic foci were detected in the right superior temporal gyrus when subjects identified sounds representing either animals or threatening items. Threatening animal stimuli elicited signal changes in both foci, suggesting a distributed neural representation. Our results demonstrate both category- and feature-specific responses to nonverbal sounds in early stages of extracting semantic memory information from these sounds. This organization allows for these category-feature detection nodes to extract early, semantic memory information for efficient processing of transient sound stimuli. Neural regions selective for threatening sounds are similar to those of nonhuman primates, demonstrating semantic memory organization for basic biological/survival primitives are present across species.
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Procedure for Adapting Direct Simulation Monte Carlo Meshes
NASA Technical Reports Server (NTRS)
Woronowicz, Michael S.; Wilmoth, Richard G.; Carlson, Ann B.; Rault, Didier F. G.
1992-01-01
A technique is presented for adapting computational meshes used in the G2 version of the direct simulation Monte Carlo method. The physical ideas underlying the technique are discussed, and adaptation formulas are developed for use on solutions generated from an initial mesh. The effect of statistical scatter on adaptation is addressed, and results demonstrate the ability of this technique to achieve more accurate results without increasing necessary computational resources.
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Results of Casting in Severe Curves in Infantile Scoliosis.
Stasikelis, Peter J; Carpenter, Ashley M
2018-04-01
Previous work has demonstrated best results for casting in infantile scoliosis when the curves are small and the child begins casting under 2 years of age. This study examines if casting can delay the need for growth friendly instrumentation in severe curves (50 to 106 degrees) and how the comorbidities of syrinx or genetic syndromes affected outcomes. All children undergoing casting for scoliosis at a single institution over an 8-year period were examined. Inclusion criteria included initial curve at first casting of ≥50 degrees, age ≤3 years at the start of casting, and a minimum follow-up of 3 years. Of 148 children undergoing casting during this period, 44 met our inclusion criteria. All children underwent magnetic resonance imaging. Ten children with a syrinx were identified. Ten children had known genetic syndromes (2 who also had a syrinx). The 26 children without these comorbidities were considered idiopathic. Curve magnitude ranged from 50 to 106 degrees. Nine of the 26 (35%) children in the children with idiopathic curves demonstrated resolution of their curves, while only 3 of the remaining 18 (17%) did. Of the children that did not have resolution of their curves, 14 were maintained over the entire follow-up period to within 15 degrees of their initial curve and 13 were improved 15 degrees or more. Only 5 children had an increase of 15 degrees or more over the follow-up period and 4 of these have undergone growth friendly instrumentation after a mean delay from initial cast of 71 months (range, 18 to 100 mo). This study demonstrates that even in severe curves, casting was effective in delaying instrumentation in all cases, and led to curve resolution of the curves in 12 of 44 children. Level III-case control study.
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Identification of spatially-localized initial conditions via sparse PCA
NASA Astrophysics Data System (ADS)
Dwivedi, Anubhav; Jovanovic, Mihailo
2017-11-01
Principal Component Analysis involves maximization of a quadratic form subject to a quadratic constraint on the initial flow perturbations and it is routinely used to identify the most energetic flow structures. For general flow configurations, principal components can be efficiently computed via power iteration of the forward and adjoint governing equations. However, the resulting flow structures typically have a large spatial support leading to a question of physical realizability. To obtain spatially-localized structures, we modify the quadratic constraint on the initial condition to include a convex combination with an additional regularization term which promotes sparsity in the physical domain. We formulate this constrained optimization problem as a nonlinear eigenvalue problem and employ an inverse power-iteration-based method to solve it. The resulting solution is guaranteed to converge to a nonlinear eigenvector which becomes increasingly localized as our emphasis on sparsity increases. We use several fluids examples to demonstrate that our method indeed identifies the most energetic initial perturbations that are spatially compact. This work was supported by Office of Naval Research through Grant Number N00014-15-1-2522.
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Bu, Lingjun; Zhou, Shiqing; Shi, Zhou; Deng, Lin; Li, Guangchao; Yi, Qihang; Gao, Naiyun
2016-02-01
The degradation kinetics and mechanism of the antiepileptic drug oxcarbazepine (OXC) by UV-activated persulfate oxidation were investigated in this study. Results showed that UV/persulfate (UV/PS) process appeared to be more effective in degrading OXC than UV or PS alone. The OXC degradation exhibited a pseudo-first order kinetics pattern and the degradation rate constants (k obs) were affected by initial OXC concentration, PS dosage, initial pH, and humic acid concentration to different degrees. It was found that low initial OXC concentration, high persulfate dosage, and initial pH enhanced the OXC degradation. Additionally, the presence of humic acid in the solution could greatly inhibit the degradation of OXC. Moreover, hydroxyl radical (OH•) and sulfate radical (SO4 (-)••) were identified to be responsible for OXC degradation and SO4 (-)• made the predominant contribution in this study. Finally, major intermediate products were identified and a preliminary degradation pathway was proposed. Results demonstrated that UV/PS system is a potential technology to control the water pollution caused by emerging contaminants such as OXC.
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Wang, Ran; Chen, Shuxun; Li, Changxian; Ng, Kevin Tak Pan; Kong, Chi-wing; Cheng, Jinping; Cheng, Shuk Han; Li, Ronald A; Lo, Chung Mau; Man, Kwan; Sun, Dong
2016-02-04
Cell fusion is a fast and highly efficient technique for cells to acquire new properties. The fusion of somatic cells with stem cells can reprogram somatic cells to a pluripotent state. Our research on the fusion of stem cells and cancer cells demonstrates that the fused cells can exhibit stemness and cancer cell-like characteristics. Thus, tumor-initiating cell-like cells are generated. We employed laser-induced single-cell fusion technique to fuse the hepatocellular carcinoma cells and human embryonic stem cells (hESC). Real-time RT-PCR, flow cytometry and in vivo tumorigenicity assay were adopted to identify the gene expression difference. We successfully produced a fused cell line that coalesces the gene expression information of hepatocellular carcinoma cells and stem cells. Experimental results showed that the fused cells expressed cancer and stemness markers as well as exhibited increased resistance to drug treatment and enhanced tumorigenesis. Fusion with stem cells transforms liver cancer cells into tumor initiating-like cells. Results indicate that fusion between cancer cell and stem cell may generate tumor initiating-like cells.
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NASA Technical Reports Server (NTRS)
Chato, David J.
1991-01-01
The results are presented of a series of no-vent fill experiments conducted on a 175 cu ft flightweight hydrogen tank. The experiments consisted of the nonvented fill of the tankage with liquid hydrogen using two different inlet systems (top spray, and bottom spray) at different tank initial conditions and inflow rates. Nine tests were completed of which six filled in excess of 94 percent. The experiments demonstrated a consistent and repeatable ability to fill the tank in excess of 94 percent using the nonvented fill technique. Ninety-four percent was established as the high level cutoff due to requirements for some tank ullage to prevent rapid tank pressure rise which occurs in a tank filled entirely with liquid. The best fill was terminated at 94 percent full with a tank internal pressure less than 26 psia. Although the baseline initial tank wall temperature criteria was that all portions of the tank wall be less than 40 R, fills were achieved with initial wall temperatures as high as 227 R.
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Xu, Mingyu; Yin, Ping; Liu, Xiguang; Tang, Qinghua; Qu, Rongjun; Xu, Qiang
2013-12-01
Novel biosorbent materials (RH-2 and RH-3) obtained from agricultural waste materials rice husks (RH-1) were successfully developed through fast and facile esterification reactions with hydroxylethylidenediphosphonic acid and nitrilotrimethylenetriphosphonic acid, respectively. The present paper reported the feasibility of using RH-1, RH-2 and RH-3 for removal of heavy metals from simulated wastewater, the results revealed that the adsorption property of functionalized rice husks with organotriphosphonic acid RH-3 for Au(III) was very excellent, especially for gold ions. The combined effect of initial solution pH, RH-3 dosage and initial Au(III) concentration was investigated using response surface methodology (RSM), the results showed that initial Au(III) concentration exerted stronger influence on Au(III) uptake than initial pH and biomass dosage. The analysis of variance (ANOVA) of the quadratic model demonstrated that the model was highly significant, and under the optimum process conditions, the maximum adsorption capacity could reach 3.25 ± 0.07 mmol/g that is higher than other reported adsorbents. Copyright © 2013 Elsevier Ltd. All rights reserved.
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40 CFR 63.10400 - How do I demonstrate initial compliance?
Code of Federal Regulations, 2010 CFR
2010-07-01
... CATEGORIES (CONTINUED) National Emission Standards for Hospital Ethylene Oxide Sterilizers Initial Compliance... submitting an Initial Notification of Compliance Status certifying that you are venting the ethylene oxide...
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Bio-inspired Design Approached Antifouling Strategies
NASA Astrophysics Data System (ADS)
Fitzsimons, L.; Chapman, J.; Lawlor, A.; Regan, F.
2012-04-01
Biofouling exists as the undesirable accumulation of flora and fauna on a given substrate when immersed into an aquatic media. Its presence causes a range of deleterious effects for anyone faced in tackling the problem, which is more than often financially testing. Generally, the initial biofouling stage is stochastic and the attachment of microorganisms held fast in biofilm matrices is irreversible. Stability of the biofilm occurs when exopolymeric substances (EPS) are produced forming a protective surrounding, allowing the cohered microorganisms to colonise and thrive upon the surface. Therefore, if this initial stage of biofilm development can be prevented then it could be possible to prevent subsequent macro events that ensue. Environmental monitoring is one area that faces this challenge and forms the impetus of the work presented herein. In order to improve a monitoring device's lifetime, surface coatings with biocidal agents are applied to counteract these steps. This work shows the development of a range of novel materials, which demonstrate the ability to counteract and inhibit the initial stages of biofouling for monitoring devices. Natural bio-inspired surfaces have been developed using nano-functionalised coatings. All materials are tested in the field and positive results in reducing the biofouling challenge are demonstrated. The results from the deployment of antifouling materials, together with real-time, long-term water quality data from the test site are also shown.
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Assimilation of water temperature and discharge data for ensemble water temperature forecasting
NASA Astrophysics Data System (ADS)
Ouellet-Proulx, Sébastien; Chimi Chiadjeu, Olivier; Boucher, Marie-Amélie; St-Hilaire, André
2017-11-01
Recent work demonstrated the value of water temperature forecasts to improve water resources allocation and highlighted the importance of quantifying their uncertainty adequately. In this study, we perform a multisite cascading ensemble assimilation of discharge and water temperature on the Nechako River (Canada) using particle filters. Hydrological and thermal initial conditions were provided to a rainfall-runoff model, coupled to a thermal module, using ensemble meteorological forecasts as inputs to produce 5 day ensemble thermal forecasts. Results show good performances of the particle filters with improvements of the accuracy of initial conditions by more than 65% compared to simulations without data assimilation for both the hydrological and the thermal component. All thermal forecasts returned continuous ranked probability scores under 0.8 °C when using a set of 40 initial conditions and meteorological forecasts comprising 20 members. A greater contribution of the initial conditions to the total uncertainty of the system for 1-dayforecasts is observed (mean ensemble spread = 1.1 °C) compared to meteorological forcings (mean ensemble spread = 0.6 °C). The inclusion of meteorological uncertainty is critical to maintain reliable forecasts and proper ensemble spread for lead times of 2 days and more. This work demonstrates the ability of the particle filters to properly update the initial conditions of a coupled hydrological and thermal model and offers insights regarding the contribution of two major sources of uncertainty to the overall uncertainty in thermal forecasts.
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Hong-Seng, Gan; Sayuti, Khairil Amir; Karim, Ahmad Helmy Abdul
2017-01-01
Existing knee cartilage segmentation methods have reported several technical drawbacks. In essence, graph cuts remains highly susceptible to image noise despite extended research interest; active shape model is often constraint by the selection of training data while shortest path have demonstrated shortcut problem in the presence of weak boundary, which is a common problem in medical images. The aims of this study is to investigate the capability of random walks as knee cartilage segmentation method. Experts would scribble on knee cartilage image to initialize random walks segmentation. Then, reproducibility of the method is assessed against manual segmentation by using Dice Similarity Index. The evaluation consists of normal cartilage and diseased cartilage sections which is divided into whole and single cartilage categories. A total of 15 normal images and 10 osteoarthritic images were included. The results showed that random walks method has demonstrated high reproducibility in both normal cartilage (observer 1: 0.83±0.028 and observer 2: 0.82±0.026) and osteoarthritic cartilage (observer 1: 0.80±0.069 and observer 2: 0.83±0.029). Besides, results from both experts were found to be consistent with each other, suggesting the inter-observer variation is insignificant (Normal: P=0.21; Diseased: P=0.15). The proposed segmentation model has overcame technical problems reported by existing semi-automated techniques and demonstrated highly reproducible and consistent results against manual segmentation method.
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Structural Basis of Mitochondrial Transcription Initiation.
Hillen, Hauke S; Morozov, Yaroslav I; Sarfallah, Azadeh; Temiakov, Dmitry; Cramer, Patrick
2017-11-16
Transcription in human mitochondria is driven by a single-subunit, factor-dependent RNA polymerase (mtRNAP). Despite its critical role in both expression and replication of the mitochondrial genome, transcription initiation by mtRNAP remains poorly understood. Here, we report crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mtRNAP to achieve promoter-dependent initiation. TFAM tethers the N-terminal region of mtRNAP to recruit the polymerase to the promoter whereas TFB2M induces structural changes in mtRNAP to enable promoter opening and trapping of the DNA non-template strand. Structural comparisons demonstrate that the initiation mechanism in mitochondria is distinct from that in the well-studied nuclear, bacterial, or bacteriophage transcription systems but that similarities are found on the topological and conceptual level. These results provide a framework for studying the regulation of gene expression and DNA replication in mitochondria. Copyright © 2017 Elsevier Inc. All rights reserved.
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Rengers, Francis K.; McGuire, Luke; Coe, Jeffrey A.; Kean, Jason W.; Baum, Rex L.; Staley, Dennis M.; Godt, Jonathan W.
2016-01-01
We explored regional influences on debris-flow initiation throughout the Colorado Front Range (Colorado, USA) by exploiting a unique data set of more than 1100 debris flows that initiated during a 5 day rainstorm in 2013. Using geospatial data, we examined the influence of rain, hillslope angle, hillslope aspect, and vegetation density on debris-flow initiation. In particular we used a greenness index to differentiate areas of high tree density from grass and bare soil. The data demonstrated an overwhelming propensity for debris-flow initiation on south-facing hillslopes. However, when the debris-flow density was analyzed with respect to total rainfall and greenness we found that most debris flows occurred in areas of high rainfall and low tree density, regardless of hillslope aspect. These results indicate that present-day tree density exerts a stronger influence on debris-flow initiation locations than aspect-driven variations in soil and bedrock properties that developed over longer time scales.
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NASA Astrophysics Data System (ADS)
Li, Yongfu; Li, Kezhi; Zheng, Taixiong; Hu, Xiangdong; Feng, Huizong; Li, Yinguo
2016-05-01
This study proposes a feedback-based platoon control protocol for connected autonomous vehicles (CAVs) under different network topologies of initial states. In particularly, algebraic graph theory is used to describe the network topology. Then, the leader-follower approach is used to model the interactions between CAVs. In addition, feedback-based protocol is designed to control the platoon considering the longitudinal and lateral gaps simultaneously as well as different network topologies. The stability and consensus of the vehicular platoon is analyzed using the Lyapunov technique. Effects of different network topologies of initial states on convergence time and robustness of platoon control are investigated. Results from numerical experiments demonstrate the effectiveness of the proposed protocol with respect to the position and velocity consensus in terms of the convergence time and robustness. Also, the findings of this study illustrate the convergence time of the control protocol is associated with the initial states, while the robustness is not affected by the initial states significantly.
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Augmenting Probabilistic Risk Assesment with Malevolent Initiators
DOE Office of Scientific and Technical Information (OSTI.GOV)
Curtis Smith; David Schwieder
2011-11-01
As commonly practiced, the use of probabilistic risk assessment (PRA) in nuclear power plants only considers accident initiators such as natural hazards, equipment failures, and human error. Malevolent initiators are ignored in PRA, but are considered the domain of physical security, which uses vulnerability assessment based on an officially specified threat (design basis threat). This paper explores the implications of augmenting and extending existing PRA models by considering new and modified scenarios resulting from malevolent initiators. Teaming the augmented PRA models with conventional vulnerability assessments can cost-effectively enhance security of a nuclear power plant. This methodology is useful for operatingmore » plants, as well as in the design of new plants. For the methodology, we have proposed an approach that builds on and extends the practice of PRA for nuclear power plants for security-related issues. Rather than only considering 'random' failures, we demonstrated a framework that is able to represent and model malevolent initiating events and associated plant impacts.« less
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Self-initiated object-location memory in young and older adults.
Berger-Mandelbaum, Anat; Magen, Hagit
2017-11-20
The present study explored self-initiated object-location memory in ecological contexts, as aspect of memory that is largely absent from the research literature. Young and older adults memorized objects-location associations they selected themselves or object-location associations provided to them, and elaborated on the strategy they used when selecting the locations themselves. Retrieval took place 30 min and 1 month after encoding. The results showed an age-related decline in self-initiated and provided object-location memory. Older adults benefited from self-initiation more than young adults when tested after 30 min, while the benefit was equal when tested after 1 month. Furthermore, elaboration enhanced memory only in older adults, and only after 30 min. Both age groups used deep encoding strategies on the majority of the trials, but their percentage was lower in older adults. Overall, the study demonstrated the processes involved in self-initiated object-location memory, which is an essential part of everyday functioning.
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Advances in Electrically Driven Thermal Management
NASA Technical Reports Server (NTRS)
Didion, Jeffrey R.
2017-01-01
Electrically Driven Thermal Management is a vibrant technology development initiative incorporating ISS based technology demonstrations, development of innovative fluid management techniques and fundamental research efforts. The program emphasizes high temperature high heat flux thermal management required for future generations of RF electronics and power electronic devices. This presentation reviews i.) preliminary results from the Electrohydrodynamic (EHD) Long Term Flight Demonstration launched on STP-H5 payload in February 2017 ii.) advances in liquid phase flow distribution control iii.) development of the Electrically Driven Liquid Film Boiling Experiment under the NASA Microgravity Fluid Physics Program.
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Identification of tumor-initiating cells derived from two canine rhabdomyosarcoma cell lines
KISHIMOTO, Takuya Evan; YASHIMA, Shoko; NAKAHIRA, Rei; ONOZAWA, Eri; AZAKAMI, Daigo; UJIKE, Makoto; OCHIAI, Kazuhiko; ISHIWATA, Toshiyuki; TAKAHASHI, Kimimasa; MICHISHITA, Masaki
2017-01-01
Cancer stem cells or tumor-initiating cells (TICs) are a small subpopulation of cells that have the capacity to self-renew, differentiate and initiate tumors. These cells may function in tumor initiation, aggression and recurrence. Whether spheres derived from canine rhabdomyosarcoma cells have stem cell-like properties is unclear. We induced sphere formation in the canine rhabdomyosarcoma cell lines, CMS-C and CMS-J, and characterized the spheres in vitro and in vivo. Sphere-forming cells were more resistant to vincristine, mitoxantrone and doxorubicin than adherent cells. Xenograft transplantation demonstrated that 1 × 103 sphere-forming cells derived from CMS-C were sufficient for tumor formation. The sphere assay showed that the sphere-forming cells were present in these tumors. These results suggest that the spheres derived from canine rhabdomyosarcoma cells may possess characteristics of TICs. This study provides the foundation for elucidating the contribution of TICs to rhabdomyosarcoma tumorigenesis. PMID:28529244
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Identification of tumor-initiating cells derived from two canine rhabdomyosarcoma cell lines.
Kishimoto, Takuya Evan; Yashima, Shoko; Nakahira, Rei; Onozawa, Eri; Azakami, Daigo; Ujike, Makoto; Ochiai, Kazuhiko; Ishiwata, Toshiyuki; Takahashi, Kimimasa; Michishita, Masaki
2017-07-07
Cancer stem cells or tumor-initiating cells (TICs) are a small subpopulation of cells that have the capacity to self-renew, differentiate and initiate tumors. These cells may function in tumor initiation, aggression and recurrence. Whether spheres derived from canine rhabdomyosarcoma cells have stem cell-like properties is unclear. We induced sphere formation in the canine rhabdomyosarcoma cell lines, CMS-C and CMS-J, and characterized the spheres in vitro and in vivo. Sphere-forming cells were more resistant to vincristine, mitoxantrone and doxorubicin than adherent cells. Xenograft transplantation demonstrated that 1 × 10 3 sphere-forming cells derived from CMS-C were sufficient for tumor formation. The sphere assay showed that the sphere-forming cells were present in these tumors. These results suggest that the spheres derived from canine rhabdomyosarcoma cells may possess characteristics of TICs. This study provides the foundation for elucidating the contribution of TICs to rhabdomyosarcoma tumorigenesis.
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Genetic variation in adaptability and pleiotropy in budding yeast
Mitchell, James Kameron; Bloom, Joshua S; Kruglyak, Leonid
2017-01-01
Evolution can favor organisms that are more adaptable, provided that genetic variation in adaptability exists. Here, we quantify this variation among 230 offspring of a cross between diverged yeast strains. We measure the adaptability of each offspring genotype, defined as its average rate of adaptation in a specific environmental condition, and analyze the heritability, predictability, and genetic basis of this trait. We find that initial genotype strongly affects adaptability and can alter the genetic basis of future evolution. Initial genotype also affects the pleiotropic consequences of adaptation for fitness in a different environment. This genetic variation in adaptability and pleiotropy is largely determined by initial fitness, according to a rule of declining adaptability with increasing initial fitness, but several individual QTLs also have a significant idiosyncratic role. Our results demonstrate that both adaptability and pleiotropy are complex traits, with extensive heritable differences arising from naturally occurring variation. PMID:28826486
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NASA Astrophysics Data System (ADS)
Jun, LIU; Huang, Wei; Hongjie, Fan
2016-02-01
A novel method for finding the initial structure parameters of an optical system via the genetic algorithm (GA) is proposed in this research. Usually, optical designers start their designs from the commonly used structures from a patent database; however, it is time consuming to modify the patented structures to meet the specification. A high-performance design result largely depends on the choice of the starting point. Accordingly, it would be highly desirable to be able to calculate the initial structure parameters automatically. In this paper, a method that combines a genetic algorithm and aberration analysis is used to determine an appropriate initial structure of an optical system. We use a three-mirror system as an example to demonstrate the validity and reliability of this method. On-axis and off-axis telecentric three-mirror systems are obtained based on this method.
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Bu, Xiangwei; Wu, Xiaoyan; Zhu, Fujing; Huang, Jiaqi; Ma, Zhen; Zhang, Rui
2015-11-01
A novel prescribed performance neural controller with unknown initial errors is addressed for the longitudinal dynamic model of a flexible air-breathing hypersonic vehicle (FAHV) subject to parametric uncertainties. Different from traditional prescribed performance control (PPC) requiring that the initial errors have to be known accurately, this paper investigates the tracking control without accurate initial errors via exploiting a new performance function. A combined neural back-stepping and minimal learning parameter (MLP) technology is employed for exploring a prescribed performance controller that provides robust tracking of velocity and altitude reference trajectories. The highlight is that the transient performance of velocity and altitude tracking errors is satisfactory and the computational load of neural approximation is low. Finally, numerical simulation results from a nonlinear FAHV model demonstrate the efficacy of the proposed strategy. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.
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Genetic variation in adaptability and pleiotropy in budding yeast.
Jerison, Elizabeth R; Kryazhimskiy, Sergey; Mitchell, James Kameron; Bloom, Joshua S; Kruglyak, Leonid; Desai, Michael M
2017-08-17
Evolution can favor organisms that are more adaptable, provided that genetic variation in adaptability exists. Here, we quantify this variation among 230 offspring of a cross between diverged yeast strains. We measure the adaptability of each offspring genotype, defined as its average rate of adaptation in a specific environmental condition, and analyze the heritability, predictability, and genetic basis of this trait. We find that initial genotype strongly affects adaptability and can alter the genetic basis of future evolution. Initial genotype also affects the pleiotropic consequences of adaptation for fitness in a different environment. This genetic variation in adaptability and pleiotropy is largely determined by initial fitness, according to a rule of declining adaptability with increasing initial fitness, but several individual QTLs also have a significant idiosyncratic role. Our results demonstrate that both adaptability and pleiotropy are complex traits, with extensive heritable differences arising from naturally occurring variation.
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Demonstrator study for micro-ranging-laser device
NASA Astrophysics Data System (ADS)
Henkel, Hartmut; Bernhardt, Bodo; Pereira do Carmo, J.
2017-11-01
Within ESA's Innovation Triangle Initiative (ITI) a demonstrator breadboard for a micro-ranging-laser device "MYLRAD" has been developed. Its working principle is the measurement of the round-trip delay time of a laser beam as a phase shift. The demonstrator consists of the laser diode (30 mW, square wave AM), optics, APD detector, narrowband preamplifier, limiter, and a phase digitiser based on a novel noise-shaping synchroniser (NSS) circuit; this works without ADCs and can be built from rad-hard components for space. The system timing and the digitiser algorithm are performed by an FPGA. The demonstrator has been tested at ranges from 1 m to 30 m. With a static non-cooperative target an RMS noise of 1 mm at a result rate of 60 Hz was reached. The demonstrator needs less than 2.5 W power.
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Least Squares Shadowing sensitivity analysis of chaotic limit cycle oscillations
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wang, Qiqi, E-mail: qiqi@mit.edu; Hu, Rui, E-mail: hurui@mit.edu; Blonigan, Patrick, E-mail: blonigan@mit.edu
2014-06-15
The adjoint method, among other sensitivity analysis methods, can fail in chaotic dynamical systems. The result from these methods can be too large, often by orders of magnitude, when the result is the derivative of a long time averaged quantity. This failure is known to be caused by ill-conditioned initial value problems. This paper overcomes this failure by replacing the initial value problem with the well-conditioned “least squares shadowing (LSS) problem”. The LSS problem is then linearized in our sensitivity analysis algorithm, which computes a derivative that converges to the derivative of the infinitely long time average. We demonstrate ourmore » algorithm in several dynamical systems exhibiting both periodic and chaotic oscillations.« less
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Molecular alignment and orientation with a hybrid Raman scattering technique
NASA Astrophysics Data System (ADS)
Bustard, Philip J.; Lausten, R.; Sussman, Benjamin J.
2012-11-01
We demonstrate a scheme for the preparation of molecular alignment and angular momentum orientation using a hybrid combination of two limits of Raman scattering. First a weak, impulsive pump pulse initializes the system via the nonresonant dynamic Stark effect. Then, having overcome the influence of the vacuum fluctuations, an amplification pulse selectively enhances the initial coherences by transient stimulated Raman scattering, generating alignment and angular momentum orientation of molecular hydrogen. The amplitude and phase of the resulting coherent dynamics are experimentally probed, indicating an amplification factor of 4.5. An analytic theory is developed to model the dynamics.
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Effect of surface crystallographic orientation on the oxidation behavior of Ni-based alloy
NASA Astrophysics Data System (ADS)
Wang, Xu; Szpunar, J. A.; Zhang, Lina
2015-02-01
Dependence of initial oxidation behavior on crystalline orientation of Haynes 230 at 900 °C was investigated by a novel method. Analysis of oxidation rate reveals that the oxide thicknesses are different for grains having different orientations. Orientation mapping was performed on oxidized specimen and grains having near {1 1 1} were easily indexed by electron backscattered diffraction. We determined that planes with deviation angle lower than 20° were all well indexed after oxidation. Results demonstrate that substrate orientation plays an important role on oxidation rate during the initial stage.
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Non-equilibrium scale invariance and shortcuts to adiabaticity in a one-dimensional Bose gas
Rohringer, W.; Fischer, D.; Steiner, F.; Mazets, I. E.; Schmiedmayer, J.; Trupke, M.
2015-01-01
We present experimental evidence for scale invariant behaviour of the excitation spectrum in phase-fluctuating quasi-1d Bose gases after a rapid change of the external trapping potential. Probing density correlations in free expansion, we find that the temperature of an initial thermal state scales with the spatial extension of the cloud as predicted by a model based on adiabatic rescaling of initial eigenmodes with conserved quasiparticle occupation numbers. Based on this result, we demonstrate that shortcuts to adiabaticity for the rapid expansion or compression of the gas do not induce additional heating. PMID:25867640
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Eshoo, Mark W.; Crowder, Christopher C.; Rebman, Alison W.; Rounds, Megan A.; Matthews, Heather E.; Picuri, John M.; Soloski, Mark J.; Ecker, David J.; Schutzer, Steven E.; Aucott, John N.
2012-01-01
Direct molecular tests in blood for early Lyme disease can be insensitive due to low amount of circulating Borrelia burgdorferi DNA. To address this challenge, we have developed a sensitive strategy to both detect and genotype B. burgdorferi directly from whole blood collected during the initial patient visit. This strategy improved sensitivity by employing 1.25 mL of whole blood, a novel pre-enrichment of the entire specimen extract for Borrelia DNA prior to a multi-locus PCR and electrospray ionization mass spectrometry detection assay. We evaluated the assay on blood collected at the initial presentation from 21 endemic area patients who had both physician-diagnosed erythema migrans (EM) and positive two-tiered serology either at the initial visit or at a follow-up visit after three weeks of antibiotic therapy. Results of this DNA analysis showed detection of B. burgdorferi in 13 of 21 patients (62%). In most cases the new assay also provided the B. burgdorferi genotype. The combined results of our direct detection assay with initial physician visit serology resulted in the detection of early Lyme disease in 19 of 21 (90%) of patients at the initial visit. In 5 of 21 cases we demonstrate the ability to detect B. burgdorferi in early Lyme disease directly from whole blood specimens prior to seroconversion. PMID:22590620
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Initialized Fractional Calculus
NASA Technical Reports Server (NTRS)
Lorenzo, Carl F.; Hartley, Tom T.
2000-01-01
This paper demonstrates the need for a nonconstant initialization for the fractional calculus and establishes a basic definition set for the initialized fractional differintegral. This definition set allows the formalization of an initialized fractional calculus. Two basis calculi are considered; the Riemann-Liouville and the Grunwald fractional calculi. Two forms of initialization, terminal and side are developed.
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Kash, Bita Arbab; Spaulding, Aaron; Johnson, Christopher E; Gamm, Larry
2014-01-01
Success factors related to the implementation of change initiatives are well documented and discussed in the management literature, but they are seldom studied in healthcare organizations engaged in multiple strategic change initiatives. The purpose of this study was to identify key success factors related to implementation of change initiatives based on rich qualitative data gathered from health leader interviews at two large health systems implementing multiple change initiatives. In-depth personal interviews with 61 healthcare leaders in the two large systems were conducted and inductive qualitative analysis was employed to identify success factors associated with 13 change initiatives. Results from this analysis were compared to success factors identified in the literature, and generalizations were drawn that add significantly to the management literature, especially to that in the healthcare sector. Ten specific success factors were identified for the implementation of change initiatives. The top three success factors were (1) culture and values, (2) business processes, and (3) people and engagement. Two of the identified success factors are unique to the healthcare sector and not found in the literature on change models: service quality and client satisfaction (ranked fourth of 10) and access to information (ranked ninth). Results demonstrate the importance of human resource functions, alignment of culture and values with change, and business processes that facilitate effective communication and access to information to achieve many change initiatives. The responses also suggest opportunities for leaders of healthcare organizations to more formally recognize the degree to which various change initiatives are dependent on one another.
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Code of Federal Regulations, 2010 CFR
2010-07-01
... preventative maintenance schedule and, as applicable, detailed descriptions of the corrective action procedures... compliance with the operation and maintenance requirements that apply to me? 63.7826 Section 63.7826... Compliance Requirements § 63.7826 How do I demonstrate initial compliance with the operation and maintenance...
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40 CFR 63.7937 - How do I demonstrate initial compliance with the general standards?
Code of Federal Regulations, 2014 CFR
2014-07-01
... compliance with the general standards? 63.7937 Section 63.7937 Protection of Environment ENVIRONMENTAL... Remediation General Compliance Requirements § 63.7937 How do I demonstrate initial compliance with the general... remediation material treated or managed by the process vented through the affected process vents has an...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Tanks § 63.7896 How do I demonstrate initial...) for the tanks to be used for your site remediation. (2) You have determined, according to the...
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40 CFR 63.7937 - How do I demonstrate initial compliance with the general standards?
Code of Federal Regulations, 2011 CFR
2011-07-01
... compliance with the general standards? 63.7937 Section 63.7937 Protection of Environment ENVIRONMENTAL... Remediation General Compliance Requirements § 63.7937 How do I demonstrate initial compliance with the general... remediation material treated or managed by the process vented through the affected process vents has an...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Tanks § 63.7896 How do I demonstrate initial...) for the tanks to be used for your site remediation. (2) You have determined, according to the...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Tanks § 63.7896 How do I demonstrate initial...) for the tanks to be used for your site remediation. (2) You have determined, according to the...
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40 CFR 63.7937 - How do I demonstrate initial compliance with the general standards?
Code of Federal Regulations, 2013 CFR
2013-07-01
... compliance with the general standards? 63.7937 Section 63.7937 Protection of Environment ENVIRONMENTAL... Remediation General Compliance Requirements § 63.7937 How do I demonstrate initial compliance with the general... remediation material treated or managed by the process vented through the affected process vents has an...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Tanks § 63.7896 How do I demonstrate initial...) for the tanks to be used for your site remediation. (2) You have determined, according to the...
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40 CFR 63.3961 - How do I demonstrate initial compliance?
Code of Federal Regulations, 2010 CFR
2010-07-01
... and Products Compliance Requirements for the Emission Rate with Add-on Controls Option § 63.3961 How do I demonstrate initial compliance? (a) You may use the emission rate with add-on controls option... option or the emission rate without add-on controls option for any coating operation in the affected...
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40 CFR 63.4561 - How do I demonstrate initial compliance?
Code of Federal Regulations, 2010 CFR
2010-07-01
... Compliance Requirements for the Emission Rate with Add-on Controls Option § 63.4561 How do I demonstrate initial compliance? (a) You may use the emission rate with add-on controls option for any coating... rate without add-on controls option for any coating operation in the affected source for which you do...
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40 CFR 63.7937 - How do I demonstrate initial compliance with the general standards?
Code of Federal Regulations, 2010 CFR
2010-07-01
... Remediation General Compliance Requirements § 63.7937 How do I demonstrate initial compliance with the general... remediation material treated or managed by the process vented through the affected process vents has an..., according to the procedures § 63.7943, and recorded the average VOHAP concentration of the remediation...
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2010-01-01
Background Growing interest and burgeoning technology for discovering genetic mechanisms that influence disease processes have ushered in a flood of genetic association studies over the last decade, yet little heritability in highly studied complex traits has been explained by genetic variation. Non-additive gene-gene interactions, which are not often explored, are thought to be one source of this "missing" heritability. Methods Stochastic methods employing evolutionary algorithms have demonstrated promise in being able to detect and model gene-gene and gene-environment interactions that influence human traits. Here we demonstrate modifications to a neural network algorithm in ATHENA (the Analysis Tool for Heritable and Environmental Network Associations) resulting in clear performance improvements for discovering gene-gene interactions that influence human traits. We employed an alternative tree-based crossover, backpropagation for locally fitting neural network weights, and incorporation of domain knowledge obtainable from publicly accessible biological databases for initializing the search for gene-gene interactions. We tested these modifications in silico using simulated datasets. Results We show that the alternative tree-based crossover modification resulted in a modest increase in the sensitivity of the ATHENA algorithm for discovering gene-gene interactions. The performance increase was highly statistically significant when backpropagation was used to locally fit NN weights. We also demonstrate that using domain knowledge to initialize the search for gene-gene interactions results in a large performance increase, especially when the search space is larger than the search coverage. Conclusions We show that a hybrid optimization procedure, alternative crossover strategies, and incorporation of domain knowledge from publicly available biological databases can result in marked increases in sensitivity and performance of the ATHENA algorithm for detecting and modelling gene-gene interactions that influence a complex human trait. PMID:20875103
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Shulman, Abraham; Strashun, Arnold M
2009-01-01
It is hypothesized that in all traumatic brain injury (TBI) patients with a clinical history of closed or penetrating head injury, the initial head trauma is associated with a vibratory sensation and noise exposure, with resultant alteration in vascular supply to the structures and contents of the fluid compartments of brain and ear (i.e., the fluid dynamics vascular theory of brain-inner-ear function [FDVTBE]). The primary etiology-head trauma-results in an initial fluctuation, interference, or interaction in the normal fluid dynamics between brain and labyrinth of the inner ear, with a resultant clinical diversity of complaints varying in time of onset and severity. Normal function of the brain and ear is a reflection of a normal state of homeostasis between the fluid compartments in the brain of cerebrospinal fluid and perilymph-endolymph in the labyrinth of the ear. The normal homeostasis in the structures and contents between the two fluid compartment systems--intracerebral and intralabyrinthine--is controlled by mechanisms involved in the maintenance of normal pressures, water and electrolyte content, and neurotransmitter activities. The initial pathophysiology (a reflection of an alteration in the vascular supply to the brain-ear) is hypothesized to be an initial acute inflammatory response, persistence of which results in ischemia and an irreversible alteration in the involved neural substrates of brain-ear. Clinically, a chronic multisymptom complex becomes manifest. The multisymptom complex, individual for each TBI patient regardless of the diagnostic TBI category (i.e., mild, moderate, or severe), initially reflects processes of inflammation and ischemia which, in brain, result in brain volume loss identified as neurodegeneration and hydrocephalus ex vacuo or an alteration in cerebrospinal fluid production (i.e., pseudotumor cerebri) and, in ear, secondary endolymphatic hydrops with associated cochleovestibular complaints of hearing loss, tinnitus, vertigo, ear blockage, and hyperacusis. The FDVTBE integrates and translates a neurovascular hypothesis for Alzheimer's disease to TBI. This study presents an FDVTBE hypothesis of TBI to explain the clinical association of head trauma (TBI) and central nervous system neurodegeneration with multisensory complaints, highlighted by and focusing on cochleovestibular complaints. A clinical case report, previously published for demonstration of the cerebrovascular medical significance of a particular type of tinnitus, and evidence-based basic science and clinical medicine are cited to provide objective evidence in support and demonstration of the FDVTBE.
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Tarescavage, Anthony M; Corey, David M; Gupton, Herbert M; Ben-Porath, Yossef S
2015-01-01
Minnesota Multiphasic Personality Inventory-2-Restructured Form scores for 145 male police officer candidates were compared with supervisor ratings of field performance and problem behaviors during their initial probationary period. Results indicated that the officers produced meaningfully lower and less variant substantive scale scores compared to the general population. After applying a statistical correction for range restriction, substantive scale scores from all domains assessed by the inventory demonstrated moderate to large correlations with performance criteria. The practical significance of these results was assessed with relative risk ratio analyses that examined the utility of specific cutoffs on scales demonstrating associations with performance criteria.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Field, Scott E.; Hesthaven, Jan S.; Lau, Stephen R.
In the context of metric perturbation theory for nonspinning black holes, extreme mass ratio binary systems are described by distributionally forced master wave equations. Numerical solution of a master wave equation as an initial boundary value problem requires initial data. However, because the correct initial data for generic-orbit systems is unknown, specification of trivial initial data is a common choice, despite being inconsistent and resulting in a solution which is initially discontinuous in time. As is well known, this choice leads to a burst of junk radiation which eventually propagates off the computational domain. We observe another potential consequence ofmore » trivial initial data: development of a persistent spurious solution, here referred to as the Jost junk solution, which contaminates the physical solution for long times. This work studies the influence of both types of junk on metric perturbations, waveforms, and self-force measurements, and it demonstrates that smooth modified source terms mollify the Jost solution and reduce junk radiation. Our concluding section discusses the applicability of these observations to other numerical schemes and techniques used to solve distributionally forced master wave equations.« less
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Recurrence of Phaeochromocytoma and Abdominal Paraganglioma After Initial Surgical Intervention
Mullan, Karen R; Atkinson, A Brew; Eatock, Fiona C; Wallace, Helen; Gray, Moyra; Hunter, Steven J
2015-01-01
Background Clinical and biochemical follow up after surgery for phaeochromocytoma is essential with long term studies demonstrating recurrence frequencies between 6% and 23%. Aim To examine the characteristics and frequency of tumour recurrence in a regional endocrine referral centre, in patients with surgical resection of phaeochromocytoma (P) and abdominal paraganglioma (AP). Methods We identified a cohort of 52 consecutive patients who attended our Regional Endocrinology & Diabetes Centre and retrospectively reviewed their clinical, biochemical and radiological data (between 2002 and 2013). After confirmation of early post-operative remission by negative biochemical testing, tumour recurrence was defined by demonstration of catecholamine excess with confirmatory imaging. Results Phaeochromocytoma was confirmed histologically in all cases (43:P, 9:AP, mean-age:53years). Open adrenalectomy was performed in 20 cases and laparoscopically in 32. Hereditary phaeochromocytoma was confirmed by genetic analysis in 12 (23%) patients. Median follow up time from initial surgery was 47 months, (range: 12 - 296 months), 49 patients had no evidence of tumour recurrence at latest follow-up. Three patients (6%) demonstrated tumour development, one in a patient with VHL which occurred in a contralateral adrenal gland, one sporadic case had local recurrence, and an adrenal tumour occurred in a patient with a SDHB gene mutation who had a previous bladder tumour. After initial surgery, the tumours occurred at 8.6, 12.0 and 17.7 years respectively. Conclusion In this study tumour development occurred in 6% of patients. Although tumour rates were low, careful and sustained clinical and biochemical follow up is advocated, as new tumour development or recurrence may occur long after the initial surgery is performed. PMID:26170485
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Proulx, Steven T.; Kwok, Edmund; You, Zhigang; Papuga, M. Owen; Beck, Christopher A.; Shealy, David J.; Ritchlin, Christopher T.; Awad, Hani A.; Boyce, Brendan F.; Xing, Lianping; Schwarz, Edward M.
2009-01-01
Objective Development of longitudinal 3D outcomes of inflammation and bone erosion in murine arthritis using contrast enhanced (CE) MRI and in vivo micro-CT; and in a pilot study, to determine the value of entrance criteria by age versus synovial volume in therapeutic intervention studies. Methods CE-MRI and in vivo micro-CT was performed on TNF-Tg and WT littermates to quantify the synovial and popliteal lymph node (LN) volumes and patella and talus bone volumes, respectively, which were validated with histology. These longitudinal outcome measures were used to assess the natural history of inflammatory-erosive arthritis. We also performed anti-TNF versus placebo efficacy studies in TNF-Tg mice in which treatment was initiated either by age (4–5 months) or synovial volume (3mm3 as detected by CE-MRI). Linear regression was performed to analyze the correlation between synovitis and focal erosion. Results CE-MRI demonstrated the highly variable nature of TNF-induced joint inflammation. Initiation of treatment by synovial volume produced significantly larger treatment effects on synovial volume (p=0.04) and lymph node volume (p<0.01) than initiation by age. By correlating the MRI and microCT data we were able to demonstrate a significant relationship between changes in synovial and patellar volumes (R2 =0.75; p<0.01). Conclusion In vivo CE-MRI and micro-CT 3D outcome measures are powerful tools that accurately demonstrate the progression of inflammatory-erosive arthritis in mice. These methods can be used to identify mice with arthritis of similar severity before intervention studies are initiated and thus minimize heterogeneity in outcome studies of chronic arthritis seen between genetically identical littermates. PMID:18050199
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Coleman-Minahan, Kate
2017-01-01
Prior research often explains the lower risk of early sexual initiation among foreign-born Mexican-origin young women by a patriarchal and sexually conservative “traditional Latino culture.” This definition overlooks structural factors such as exploitation of migrant workers, and conflates gender inequality and sexual expectations. I use an intersectional framework and the theory of gender and power to explore how gender inequality and sexual expectations are both influenced by structural factors and affect reproductive health outcomes. I integrate data from qualitative interviews with 21 first and second generation Mexican-origin women in 2013–2014 with data from discrete time hazard models with 798 Mexican-origin young women in the National Longitudinal Study of Adolescent to Adult Health. Qualitative results demonstrate that gender inequality and sexual expectations in Mexican-origin immigrant households are associated with structural factors. Gender inequality occurs more often in households with family instability, greater poverty, and among parents who migrated independently. Qualitative data also demonstrate that parental gendered expectations are sometimes at odds to what parents are actually doing in the household. Finally, contrary to assumptions that a patriarchal “traditional Latino culture” protects against early sexual initiation, qualitative and multivariate quantitative data suggest that household gender inequality increases risk of early sexual initiation. These findings challenge the utility of a culturalist approach that views culture as determining behavior to explain health disparities among immigrants and demonstrate the need to incorporate an intersectional framework that includes structural factors. This approach may reduce stereotypes and identify meaningful interventions to reduce reproductive health disparities. PMID:28324794
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Kataoka, Ken; Kim, Dae Joon; Carbajal, Steve; Clifford, John L; DiGiovanni, John
2008-06-01
Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been found in a variety of human malignancies and has been suggested to play an important role in carcinogenesis. Recently, our laboratory demonstrated that Stat3 is required for the development of skin tumors via two-stage carcinogenesis using skin-specific loss-of-function transgenic mice. To investigate further the role of Stat3 in each stage of chemical carcinogenesis in mouse skin, i.e. initiation and promotion stages, we generated inducible Stat3-deficient mice (K5.Cre-ER(T2) x Stat3(fl/fl)) that show epidermal-specific disruption of Stat3 following topical treatment with 4-hydroxytamoxifen (TM). The epidermis of inducible Stat3-deficient mice treated with TM showed a significant increase in apoptosis induced by 7,12-dimethylbenz[a]anthracene (DMBA) and reduced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate. In two-stage skin carcinogenesis assays, inducible Stat3-deficient mice treated with TM during the promotion stage showed a significant delay of tumor development and a significantly reduced number of tumors compared with control groups. Inducible Stat3-deficient mice treated with TM before initiation with DMBA also showed a significant delay in tumor development and a significantly reduced number of tumors compared with control groups. Finally, treatment of inducible Stat3-deficient mice that had existing skin tumors generated by the two-stage carcinogenesis protocol with TM (by intraperitoneal injection) led to inhibition of tumor growth compared with tumors formed in control groups. Collectively, these results directly demonstrate that Stat3 is required for skin tumor development during both the initiation and promotion stages of skin carcinogenesis in vivo.
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Wallace, Louise M; Ma, Yuanying; Qiu, Li Qian; Dunn, Orla M
2018-04-26
UNICEF Baby Friendly Initiative (BFHI) is the global standard for maternity and community services requiring all practitioners to be trained to support mothers in the essential skills of supporting positioning and attachment, and hand expression. These studies aim to rigorously assess knowledge in nurses, midwives, and doctors in these skills, tested before and after watching short videos demonstrating these skills. Practitioners were attending BFHI education, and the video study was additional. In Phase 1 clinicians in England were randomised to one of two videos (practitioner role play or clinical demonstration). The results showed improvements in knowledge and confidence, and a preference for clinical demonstration by mothers and infants. The clinical demonstration video was evaluated in China in Phase 2 where expert trainers viewed the video after completing the BHFI workshop, and in Phase 3 practitioners viewed the video before the BHFI workshop. Phase 2 with expert trainers only showed improvement in knowledge of hand expression but not positioning and attachment. In Phase 3 clinicians showed improved knowledge for both skills. In all Phases there were statistically significant improvements in confidence in practice in both skills. Viewing short videos increased knowledge, particularly about teaching hand expression, and confidence in both skills. Copyright © 2018. Published by Elsevier Ltd.
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2011-04-01
castrate resistant pros- tate cancer that initially undergoes a latency period (possibly quiescent low proliferating tumors as docu- mented in the...our results demonstrate that low dose concurrent panobinostat/everolimus combination therapy is well tolerated and results in greater anti-tumor...and dose dependent manner, where as Myc-CaP cell lines were resistant to the cytotoxic effects of everolimus. Treatment with low dose (non
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Description and Evaluation of a Four-Channel, Coherent 100-kHz Sidescan Sonar
2004-12-01
document contains color images. 14. ABSTRACT This report documents the design and features of a new, four-channel, coherent 100-kHz sidescan sonar...Atlantic Technical Memorandum DRDC Atlantic TM 2004-204 December 2004 Abstract This report documents the design and features of a new...Results This report documents the design and features of this new high-frequency sonar system. These initial field trial results demonstrate some of
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Initial Results of a New Clinical Practice Model: Impact on Learners at Risk
ERIC Educational Resources Information Center
Wasburn-Moses, Leah; Noltemeyer, Amity L.; Schmitz, Kristin J.
2015-01-01
The last several years have seen a dramatic increase in interest surrounding the role of clinical experiences in enhancing the learning of teacher candidates. Further, pressure has intensified to demonstrate the impact of teacher candidates on P-12 learners. With these goals in mind, a model alternative school/university partnership was created,…
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Fisher population and landscape genetics
Michael Schwartz; Joel Saunder; Kristine L. Pilgrim; Ray Vinkey; Michael K. Lucid; Sean Parks; Nathan Albrecht
2013-01-01
This talk provides a population and landscape genetic overview of fishers in Idaho and Montana. We start by discussing some of our initial findings using mitochondrial DNA (Vinkey et al. 2006, Schwartz 2007, Knaus et al. 2011). On balance these results demonstrate the uniqueness of a native haplotype that persisted in the Bitterroot-Selway Ecosystem. They also show the...
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Paul B. Hamel
2003-01-01
Forest community restoration in the primarily agricultural landscape of the Lower Mississippi Alluvial Valley (LMAV), USA, has been initiated for recreational, economic and biological objectives, including provision of habitat for migratory birds of late successional stands. A long-term demonstration experiment of succession under several afforestation treatments was...
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Improve Your Marketing Results by Asking Peter F. Drucker's "Five Most Important Questions."
ERIC Educational Resources Information Center
Rossum, Constance; Baum, Geoffrey
2001-01-01
This case study demonstrates how the Office of Marketing & Public Relations at Claremont McKenna College used five "Drucker Tool" questions to improve marketing's image on campus and awareness of the college among key constituencies. It concludes with a reevaluation of the initial marketing strategy based on the growing importance of…
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-12
... are part of the treatment and control groups, as well as PHA staff. Data will be gathered through a... a group of FSS participants from initial enrollment to program completion (or exit). The intent is... driving observed results. The demonstration will document the progress of a group of FSS participants from...
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Dealing with Free-Riders in Assessed Group Work: Results from a Study at a UK University
ERIC Educational Resources Information Center
Maiden, Barbara; Perry, Bob
2011-01-01
Potential employers require graduates to be able to demonstrate competent teamwork skills in initiating ideas and solving problems cooperatively. Teamwork is prevalent in educational institutions and often included as a way of enriching learning and assessment. Whilst group working can provide a rich opportunity for cooperative learning, its…
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Strict parabolicity of the multifractal spectrum at the Anderson transition
DOE Office of Scientific and Technical Information (OSTI.GOV)
Suslov, I. M., E-mail: suslov@kapitza.ras.ru
Using the well-known “algebra of multifractality,” we derive the functional equation for anomalous dimensions Δ{sub q}, whose solution Δ = χq(q–1) corresponds to strict parabolicity of the multifractal spectrum. This result demonstrates clearly that a correspondence of the nonlinear σ-models with the initial disordered systems is not exact.
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A Visualization Case Study of Feature Vector and Stemmer Effects on TREC Topic-document Subsets.
ERIC Educational Resources Information Center
Rorvig, Mark T.; Sullivan, Terry; Oyarce, Guillermo
1998-01-01
Demonstrates a method of visual analysis which takes advantage of the pooling technique of topic-document set creation in the TREC collection. Describes the procedures used to create the initial visual fields, and their respective treatments as vectors without stemming and vectors with stemming; discusses results of these treatments and…
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ERIC Educational Resources Information Center
Colorado State Dept. of Education, Denver. Special Education Services Unit.
The report summarizes five Colorado teacher research projects in teaching students with disabilities. The five projects described demonstrate that teacher initiated classroom based research allows educators to develop innovative approaches to instruction and to analyze their results in an objective way. The following projects are presented: (1)…
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Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins.
O'Connor, Marie N; Salles, Isabelle I; Cvejic, Ana; Watkins, Nicholas A; Walker, Adam; Garner, Stephen F; Jones, Chris I; Macaulay, Iain C; Steward, Michael; Zwaginga, Jaap-Jan; Bray, Sarah L; Dudbridge, Frank; de Bono, Bernard; Goodall, Alison H; Deckmyn, Hans; Stemple, Derek L; Ouwehand, Willem H
2009-05-07
In this study, we demonstrate the suitability of the vertebrate Danio rerio (zebrafish) for functional screening of novel platelet genes in vivo by reverse genetics. Comparative transcript analysis of platelets and their precursor cell, the megakaryocyte, together with nucleated blood cell elements, endothelial cells, and erythroblasts, identified novel platelet membrane proteins with hitherto unknown roles in thrombus formation. We determined the phenotype induced by antisense morpholino oligonucleotide (MO)-based knockdown of 5 of these genes in a laser-induced arterial thrombosis model. To validate the model, the genes for platelet glycoprotein (GP) IIb and the coagulation protein factor VIII were targeted. MO-injected fish showed normal thrombus initiation but severely impaired thrombus growth, consistent with the mouse knockout phenotypes, and concomitant knockdown of both resulted in spontaneous bleeding. Knockdown of 4 of the 5 novel platelet proteins altered arterial thrombosis, as demonstrated by modified kinetics of thrombus initiation and/or development. We identified a putative role for BAMBI and LRRC32 in promotion and DCBLD2 and ESAM in inhibition of thrombus formation. We conclude that phenotypic analysis of MO-injected zebrafish is a fast and powerful method for initial screening of novel platelet proteins for function in thrombosis.
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Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins
O'Connor, Marie N.; Salles, Isabelle I.; Cvejic, Ana; Watkins, Nicholas A.; Walker, Adam; Garner, Stephen F.; Jones, Chris I.; Macaulay, Iain C.; Steward, Michael; Zwaginga, Jaap-Jan; Bray, Sarah L.; Dudbridge, Frank; de Bono, Bernard; Goodall, Alison H.; Stemple, Derek L.; Ouwehand, Willem H.
2009-01-01
In this study, we demonstrate the suitability of the vertebrate Danio rerio (zebrafish) for functional screening of novel platelet genes in vivo by reverse genetics. Comparative transcript analysis of platelets and their precursor cell, the megakaryocyte, together with nucleated blood cell elements, endothelial cells, and erythroblasts, identified novel platelet membrane proteins with hitherto unknown roles in thrombus formation. We determined the phenotype induced by antisense morpholino oligonucleotide (MO)–based knockdown of 5 of these genes in a laser-induced arterial thrombosis model. To validate the model, the genes for platelet glycoprotein (GP) IIb and the coagulation protein factor VIII were targeted. MO-injected fish showed normal thrombus initiation but severely impaired thrombus growth, consistent with the mouse knockout phenotypes, and concomitant knockdown of both resulted in spontaneous bleeding. Knockdown of 4 of the 5 novel platelet proteins altered arterial thrombosis, as demonstrated by modified kinetics of thrombus initiation and/or development. We identified a putative role for BAMBI and LRRC32 in promotion and DCBLD2 and ESAM in inhibition of thrombus formation. We conclude that phenotypic analysis of MO-injected zebrafish is a fast and powerful method for initial screening of novel platelet proteins for function in thrombosis. PMID:19109564
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Torous, John
2017-01-01
Research studies that leverage emerging technologies, such as passive sensing devices and mobile apps, have demonstrated encouraging potential with respect to favorably influencing the human condition. As a result, the nascent fields of mHealth and digital medicine have gained traction over the past decade as demonstrated in the United States by increased federal funding for research that cuts across a broad spectrum of health conditions. The existence of mHealth and digital medicine also introduced new ethical and regulatory challenges that both institutional review boards (IRBs) and researchers are struggling to navigate. In response, the Connected and Open Research Ethics (CORE) initiative was launched. The CORE initiative has employed a participatory research approach, whereby researchers and IRB affiliates are involved in identifying the priorities and functionality of a shared resource. The overarching goal of CORE is to develop dynamic and relevant ethical practices to guide mHealth and digital medicine research. In this Viewpoint paper, we describe the CORE initiative and call for readers to join the CORE Network and contribute to the bigger conversation on ethics in the digital age. PMID:28179216
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Ruiz, Yumary; Matos, Sergio; Kapadia, Smiti; Islam, Nadia; Cusack, Arthur; Kwong, Sylvia; Trinh-Shevrin, Chau
2012-12-01
Despite the importance of community health workers (CHWs) in strategies to reduce health disparities and the call to enhance their roles in research, little information exists on how to prepare CHWs involved in community-academic initiatives (CAIs). Therefore, the New York University Prevention Research Center piloted a CAI-CHW training program. We applied a core competency framework to an existing CHW curriculum and bolstered the curriculum to include research-specific sessions. We employed diverse training methods, guided by adult learning principles and popular education philosophy. Evaluation instruments assessed changes related to confidence, intention to use learned skills, usefulness of sessions, and satisfaction with the training. Results demonstrated that a core competency-based training can successfully affect CHWs' perceived confidence and intentions to apply learned content, and can provide a larger social justice context of their role and work. This program demonstrates that a core competency-based framework coupled with CAI-research-specific skill sessions (1) provides skills that CAI-CHWs intend to use, (2) builds confidence, and (3) provides participants with a more contextualized view of client needs and CHW roles.
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Harmonisation of seven common enzyme results through EQA.
Weykamp, Cas; Franck, Paul; Gunnewiek, Jacqueline Klein; de Jonge, Robert; Kuypers, Aldy; van Loon, Douwe; Steigstra, Herman; Cobbaert, Christa
2014-11-01
Equivalent results between different laboratories enable optimal patient care and can be achieved with harmonisation. We report on EQA-initiated national harmonisation of seven enzymes using commutable samples. EQA samples were prepared from human serum spiked with human recombinant enzymes. Target values were assigned with the IFCC Reference Measurement Procedures. The same samples were included at four occasions in the EQA programmes of 2012 and 2013. Laboratories were encouraged to report IFCC traceable results. A parallel study was done to confirm commutability of the samples. Of the 223 participating laboratories, 95% reported IFCC traceable results, ranging from 98% (ASAT) to 87% (amylase). Users of Roche and Siemens (97%) more frequently reported in IFCC traceable results than users of Abbott (91%), Beckman (90%), and Olympus (87%). The success of harmonisation, expressed as the recovery of assigned values and the inter-laboratory CV was: ALAT (recovery 100%; inter-lab CV 4%), ASAT (102%; 4%), LD (98%; 3%), CK (101%; 5%), GGT (98%; 4%), AP (96%; 6%), amylase (99%; 4%). There were no significant differences between the manufacturers. Commutability was demonstrated in the parallel study. Equal results in the same sample in the 2012 and 2013 EQA programmes demonstrated stability of the samples. The EQA-initiated national harmonisation of seven enzymes, using stable, commutable human serum samples, spiked with human recombinant enzymes, and targeted with the IFCC Reference Measurement Procedures, was successful in terms of implementation of IFCC traceable results (95%), recovery of the target (99%), and inter-laboratory CV (4%).
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Pevnick, Joshua M.; Fuller, Garth; Duncan, Ray; Spiegel, Brennan M. R.
2016-01-01
Background Personal fitness trackers (PFT) have substantial potential to improve healthcare. Objective To quantify and characterize early adopters who shared their PFT data with providers. Methods We used bivariate statistics and logistic regression to compare patients who shared any PFT data vs. patients who did not. Results A patient portal was used to invite 79,953 registered portal users to share their data. Of 66,105 users included in our analysis, 499 (0.8%) uploaded data during an initial 37-day study period. Bivariate and regression analysis showed that early adopters were more likely than non-adopters to be younger, male, white, health system employees, and to have higher BMIs. Neither comorbidities nor utilization predicted adoption. Conclusion Our results demonstrate that patients had little intrinsic desire to share PFT data with their providers, and suggest that patients most at risk for poor health outcomes are least likely to share PFT data. Marketing, incentives, and/or cultural change may be needed to induce such data-sharing. PMID:27846287
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Fatigue damage behavior of a surface-mount electronic package under different cyclic applied loads
NASA Astrophysics Data System (ADS)
Ren, Huai-Hui; Wang, Xi-Shu
2014-04-01
This paper studies and compares the effects of pull-pull and 3-point bending cyclic loadings on the mechanical fatigue damage behaviors of a solder joint in a surface-mount electronic package. The comparisons are based on experimental investigations using scanning electron microscopy (SEM) in-situ technology and nonlinear finite element modeling, respectively. The compared results indicate that there are different threshold levels of plastic strain for the initial damage of solder joints under two cyclic applied loads; meanwhile, fatigue crack initiation occurs at different locations, and the accumulation of equivalent plastic strain determines the trend and direction of fatigue crack propagation. In addition, simulation results of the fatigue damage process of solder joints considering a constitutive model of damage initiation criteria for ductile materials and damage evolution based on accumulating inelastic hysteresis energy are identical to the experimental results. The actual fatigue life of the solder joint is almost the same and demonstrates that the FE modeling used in this study can provide an accurate prediction of solder joint fatigue failure.
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NASA Technical Reports Server (NTRS)
Garcia, Daniel B.; Forman, Royce; Shindo, David
2010-01-01
A test program was developed and executed to evaluate the influence of corroded hemispherical notches on the fatigue crack initiation and propagation in aluminum 7075-T7351, 4340 steel, and D6AC steel. Surface enhancements such as shot peening and laser shock peening were also incorporated as part of the test effort with the intent of improving fatigue performance. In addition to the testing, fracture mechanics and endurance limit based analysis methods were evaluated to characterize the results with the objective of challenging typical assumptions used in modeling fatigue cracks from corrosion pits. The results specifically demonstrate that the aluminum and steel alloys behave differently with respect to fatigue crack initiation from hemispherical corrosion pits. The aluminum test results were bounded by the fracture mechanics and endurance limit models while exhibiting a general insensitivity to the residual stress field generated by shot peening. The steel specimens were better characterized by the endurance limit fatigue properties and did exhibit sensitivities to residual stresses from the shot peening and laser shock peening
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Impact of Exposure to Childhood Maltreatment on Transitions to Alcohol Dependence in Women and Men.
Oberleitner, Lindsay M S; Smith, Philip H; Weinberger, Andrea H; Mazure, Carolyn M; McKee, Sherry A
2015-11-01
Childhood maltreatment decreases age of first use and speeds the transition from first use to dependence (i.e., telescoping) for alcohol use, however, it is currently unknown whether this influence is the same for men and women. Analyses were conducted with the National Epidemiologic Survey on Alcohol and Related Conditions (n = 34,653). Outcome variables included age of alcohol initiation and time to onset of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition alcohol dependence. Predictor variables included gender and childhood maltreatment. Linear and Poisson regression analyses were conducted. Results demonstrated that in regard to age of drinking initiation, individuals who experienced childhood maltreatment initiated 1 year earlier than those without maltreatment, however, there was no interaction of this relationship with gender. Regarding the time to dependence, it was found that women who experienced childhood maltreatment demonstrated telescoping (shorter time between onset and dependence) compared to women without maltreatment and men (both with and without maltreatment). Women with a history of childhood maltreatment are particularly vulnerable to an accelerated time from initiation of alcohol use until dependence, a pattern indicative of increased negative alcohol-related outcomes. Findings highlight the need for development of gender-specific prevention efforts and behavioral treatments to aid in early intervention of problematic alcohol use in women. © The Author(s) 2015.
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DNA immobilization and detection on cellulose paper using a surface grown cationic polymer via ATRP.
Aied, Ahmed; Zheng, Yu; Pandit, Abhay; Wang, Wenxin
2012-02-01
Cationic polymers with various structures have been widely investigated in the areas of medical diagnostics and molecular biology because of their unique binding properties and capability to interact with biological molecules in complex biological environments. In this work, we report the grafting of a linear cationic polymer from an atom transfer radical polymerization (ATRP) initiator bound to cellulose paper surface. We show successful binding of ATRP initiator onto cellulose paper and grafting of polymer chains from the immobilized initiator with ATRP. The cellulose paper grafted polymer was used in combination with PicoGreen (PG) to demonstrate detection of nucleic acids in the nanogram range in homogeneous solution and in a biological sample (serum). The results showed specific identification of hybridized DNA after addition of PG in both solutions.
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A magma ocean and the Earth's internal water budget
NASA Technical Reports Server (NTRS)
Ahrens, Thomas J.
1992-01-01
There are lines of evidence which relate bounds on the primordial water content of the Earth's mantle to a magma ocean and the accompanying Earth accretion process. We assume initially (before a magma ocean could form) that as the Earth accreted, it grew from volatile- (H2O, CO2, NH3, CH4, SO2, plus noble) gas-rich planetesimals, which accreted to form an initial 'primitive accretion core' (PAC). The PAC retained the initial complement of planetesimal gaseous components. Shock wave experiments in which both solid, and more recently, the gaseous components of materials such as serpentine and the Murchison meteorite have demonstrated that planetesimal infall velocities of less than 0.5 km/sec, induce shock pressures of less than 0.5 GPa and result in virtually complete retention of planetary gases.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Yang, Liang; Wang, C. Z.; Lin, Shiwei
Understanding of metal oxidation is very critical to corrosion control, catalysis synthesis, and advanced materials engineering. Metal oxidation is a very complex phenomenon, with many different processes which are coupled and involved from the onset of reaction. In this work, the initial stage of oxidation on titanium surface was investigated in atomic scale by molecular dynamics (MD) simulations using a reactive force field (ReaxFF). We show that oxygen transport is the dominant process during the initial oxidation. Our simulation also demonstrate that a compressive stress was generated in the oxide layer which blocked the oxygen transport perpendicular to the Titaniummore » (0001) surface and further prevented oxidation in the deeper layers. As a result, the mechanism of initial oxidation observed in this work can be also applicable to other self-limiting oxidation.« less
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Achalasia following gastro-oesophageal reflux.
Smart, H L; Mayberry, J F; Atkinson, M
1986-01-01
Five patients initially presenting with symptomatic gastro-oesophageal reflux, proven by radiology or pH monitoring, subsequently developed achalasia, confirmed by radiology and manometry, after an interval of 2-10 years. During this period dysphagia, present as a mild and intermittent symptom accompanying the initial reflux in 3 of the 5, became severe and resulted in oesophageal stasis of food in all. Three of the 5 had a demonstrable hiatal hernia. In none was reflux a troublesome symptom after Rider-Moeller dilatation or cardiomyotomy undertaken for the achalasia. Gastro-oesophageal reflux does not protect against the subsequent development of achalasia. It is suggested that the autonomic damage eventually leading to achalasia may in its initial phases cause gastro-oesophageal reflux. Images Figure 1. A Figure 1. B Figure 2. PMID:3950898
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Brown, K; Buchmann, A; Balmain, A
1990-01-01
A number of mouse skin tumors initiated by the carcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), methylnitrosourea (MNU), 3-methylcholanthrene (MCA), and 7,12-dimethylbenz[a]anthracene (DMBA) have been shown to contain activated Ha-ras genes. In each case, the point mutations responsible for activation have been characterized. Results presented demonstrate the carcinogen-specific nature of these ras mutations. For each initiating agent, a distinct spectrum of mutations is observed. Most importantly, the distribution of ras gene mutations is found to differ between benign papillomas and carcinomas, suggesting that molecular events occurring at the time of initiation influence the probability with which papillomas progress to malignancy. This study provides molecular evidence in support of the existence of subsets of papillomas with differing progression frequencies. Thus, the alkylating agents MNNG and MNU induced exclusively G ---- A transitions at codon 12, with this mutation being found predominantly in papillomas. MCA initiation produced both codon 13 G ---- T and codon 61 A ---- T transversions in papillomas; only the G ---- T mutation, however, was found in carcinomas. These findings provide strong evidence that the mutational activation of Ha-ras occurs as a result of the initiation process and that the nature of the initiating event can affect the probability of progression to malignancy. Images PMID:2105486
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Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol
Cencic, Regina; Carrier, Marilyn; Galicia-Vázquez, Gabriela; Bordeleau, Marie-Eve; Sukarieh, Rami; Bourdeau, Annie; Brem, Brigitte; Teodoro, Jose G.; Greger, Harald; Tremblay, Michel L.; Porco, John A.; Pelletier, Jerry
2009-01-01
Background Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been shown to modulate the activity of eIF4A, the DEAD-box RNA helicase subunit of the eukaryotic initiation factor (eIF) 4F complex, a complex that stimulates ribosome recruitment during translation initiation. One flavagline, silvestrol, is capable of modulating chemosensitivity in a mechanism-based mouse model. Methodology/Principal Findings Among a number of flavagline family members tested herein, we find that silvestrol is the more potent translation inhibitor among these. We find that silvestrol impairs the ribosome recruitment step of translation initiation by affecting the composition of the eukaryotic initiation factor (eIF) 4F complex. We show that silvestrol exhibits significant anticancer activity in human breast and prostate cancer xenograft models, and that this is associated with increased apoptosis, decreased proliferation, and inhibition of angiogenesis. We demonstrate that targeting translation by silvestrol results in preferential inhibition of weakly initiating mRNAs. Conclusions/Significance Our results indicate that silvestrol is a potent anti-cancer compound in vivo that exerts its activity by affecting survival pathways as well as angiogenesis. We propose that silvestrol mediates its effects by preferentially inhibiting translation of malignancy-related mRNAs. Silvestrol appears to be well tolerated in animals. PMID:19401772
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Code of Federal Regulations, 2013 CFR
2013-07-01
... Hazardous Air Pollutants: Coal- and Oil-Fired Electric Utility Steam Generating Units Testing and Initial... liquid oil-fired unit, and you use quarterly stack testing for HCl and HF plus site-specific parameter monitoring to demonstrate continuous performance, you must also establish a site-specific operating limit, in...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... Hazardous Air Pollutants: Coal- and Oil-Fired Electric Utility Steam Generating Units Testing and Initial... liquid oil-fired unit, and you use quarterly stack testing for HCl and HF plus site-specific parameter monitoring to demonstrate continuous performance, you must also establish a site-specific operating limit, in...
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40 CFR 63.4751 - How do I demonstrate initial compliance with the emission limitations?
Code of Federal Regulations, 2010 CFR
2010-07-01
... emission rate without add-on controls option for any individual coating operation, for any group of coating operations in the affected source, or for all the coating operations in the affected source. You must use... operation in the affected source for which you do not use this option. To demonstrate initial compliance...
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40 CFR 63.4151 - How do I demonstrate initial compliance with the emission limitations?
Code of Federal Regulations, 2010 CFR
2010-07-01
... without add-on controls option for any individual coating operation, for any group of coating operations in the affected source, or for all of the coating operations in the affected source. You must use... operation(s) in the affected source for which you do not use this option. To demonstrate initial compliance...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Containers § 63.7901 How do I demonstrate initial... specified in § 63.7990 for the containers to be used for your site remediation. (2) You have determined and...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Containers § 63.7901 How do I demonstrate initial... specified in § 63.7990 for the containers to be used for your site remediation. (2) You have determined and...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Containers § 63.7901 How do I demonstrate initial... specified in § 63.7990 for the containers to be used for your site remediation. (2) You have determined and...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Standards for Hazardous Air Pollutants: Site Remediation Containers § 63.7901 How do I demonstrate initial... specified in § 63.7990 for the containers to be used for your site remediation. (2) You have determined and...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... must I use to demonstrate initial compliance with the emission limits for particulate matter? 63.9621... the emission limits for particulate matter? (a) You must conduct each performance test that applies to... source, you must determine compliance with the applicable emission limit for particulate matter in Table...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... must I use to demonstrate initial compliance with the emission limits for particulate matter? 63.9621... the emission limits for particulate matter? (a) You must conduct each performance test that applies to... source, you must determine compliance with the applicable emission limit for particulate matter in Table...
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ERIC Educational Resources Information Center
Pasnik, Shelley; Llorente, Carlin
2012-01-01
The 2012 Transmedia Demonstration Stations program study is part of the multiyear CPB-PBS "Ready To Learn" summative evaluation initiative by Education Development Center, Inc., (EDC) and SRI International (SRI). Through a series of related studies, the authors are documenting, and, whenever possible, measuring the impact of PBS KIDS…
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NASA Technical Reports Server (NTRS)
Haas, Lin; Massey, Christopher; Baraban, Dmitri
2003-01-01
This paper presents the Global Positioning System (GPS) navigation results from the Communications and Navigation Demonstration on Shuttle (CANDOS) experiment flown on STS-107. This experiment was the initial flight of a Low Power Transceiver (LPT) that featured high capacity space- space and space-ground communications and GPS- based navigation capabilities. The LPT also hosted the GPS Enhanced Orbit Determination Experiment (GEODE) orbit determination software. All CANDOS test data were recovered during the mission using LPT communications links via the Tracking and Data Relay Satellite System (TDRSS). An overview of the LPT s navigation software and the GPS experiment timeline is presented, along with comparisons of test results to the NASA Johnson Space Center (JSC) real-time ground navigation vectors and Best Estimate of Trajectory (BET).
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iTRAQ-Based Quantitative Proteomic Analysis of the Initiation of Head Regeneration in Planarians.
Geng, Xiaofang; Wang, Gaiping; Qin, Yanli; Zang, Xiayan; Li, Pengfei; Geng, Zhi; Xue, Deming; Dong, Zimei; Ma, Kexue; Chen, Guangwen; Xu, Cunshuan
2015-01-01
The planarian Dugesia japonica has amazing ability to regenerate a head from the anterior ends of the amputated stump with maintenance of the original anterior-posterior polarity. Although planarians present an attractive system for molecular investigation of regeneration and research has focused on clarifying the molecular mechanism of regeneration initiation in planarians at transcriptional level, but the initiation mechanism of planarian head regeneration (PHR) remains unclear at the protein level. Here, a global analysis of proteome dynamics during the early stage of PHR was performed using isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomics strategy, and our data are available via ProteomeXchange with identifier PXD002100. The results showed that 162 proteins were differentially expressed at 2 h and 6 h following amputation. Furthermore, the analysis of expression patterns and functional enrichment of the differentially expressed proteins showed that proteins involved in muscle contraction, oxidation reduction and protein synthesis were up-regulated in the initiation of PHR. Moreover, ingenuity pathway analysis showed that predominant signaling pathways such as ILK, calcium, EIF2 and mTOR signaling which were associated with cell migration, cell proliferation and protein synthesis were likely to be involved in the initiation of PHR. The results for the first time demonstrated that muscle contraction and ILK signaling might played important roles in the initiation of PHR at the global protein level. The findings of this research provide a molecular basis for further unraveling the mechanism of head regeneration initiation in planarians.
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NASA Astrophysics Data System (ADS)
Mao, Liucheng; Liu, Xinhua; Liu, Meiying; Huang, Long; Xu, Dazhuang; Jiang, Ruming; Huang, Qiang; Wen, Yuanqing; Zhang, Xiaoyong; Wei, Yen
2017-10-01
Aggregation-induced emission (AIE) dyes have recently been intensively explored for biological imaging applications owing to their outstanding optical feature as compared with conventional organic dyes. The AIE-active luminescent silica nanoparticles (LSNPs) are expected to combine the advantages both of silica nanoparticles and AIE-active dyes. Although the AIE-active LSNPs have been prepared previously, surface modification of these AIE-active LSNPs with functional polymers has not been reported thus far. In this work, we reported a rather facile and general strategy for preparation of polymers functionalized AIE-active LSNPs through the surface-initiated atom transfer radical polymerization (ATRP). The AIE-active LSNPs were fabricated via direct encapsulation of AIE-active dye into silica nanoparticles through a non-covalent modified Stöber method. The ATRP initiator was subsequently immobilized onto these AIE-active LSNPs through amidation reaction between 3-aminopropyl-triethoxy-silane and 2-bromoisobutyryl bromide. Finally, the zwitterionic 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) was selected as model monomer and grafted onto MSNs through ATRP. The characterization results suggested that LSNPs can be successfully modified with poly(MPC) through surface-initiated ATRP. The biological evaluation results demonstrated that the final SNPs-AIE-pMPC composites possess low cytotoxicity, desirable optical properties and great potential for biological imaging. Taken together, we demonstrated that AIE-active LSNPs can be fabricated and surface modified with functional polymers to endow novel functions and better performance for biomedical applications. More importantly, this strategy developed in this work could also be extended for fabrication of many other LSNPs polymer composites owing to the good monomer adoptability of ATRP.
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Adiabatic invariants in stellar dynamics, 3: Application to globular cluster evolution
NASA Technical Reports Server (NTRS)
Weinberg, Martin D.
1994-01-01
The previous two companion papers demonstrate that slowly varying perturbations may not result in adiabatic cutoffs and provide a formalism for computing the long-term effects of time-dependent perturbations on stellar systems. Here, the theory is implemented in a Fokker-Planck code and a suite of runs illustrating the effects of shock heating on globular cluster evolution are described. Shock heating alone results in considerable mass loss for clusters with R(sub g) less than or approximately 8 kpc: a concentration c = 1.5 cluster with R(sub g) kpc loses up to 95% of its initial mass in 15 Gyr. Only those with concentration c greater than or approximately 1.3 survive disk shocks inside of this radius. Other effects, such as mass loss by stellar evolution, will decrease this survival bound. Loss of the initial halo together with mass segregation leads to mass spectral indices, x, which may be considerably larger than their initial values.
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Simulations of Heterogeneous Detonations and Post Detonation Turbulent Mixing and Afterburning
NASA Astrophysics Data System (ADS)
Menon, Suresh; Gottiparthi, Kalyana
2011-06-01
Most metal-loaded explosives and thermobaric explosives exploit the afterburning of metals to maintain pressure and temperature conditions.The use of such explosives in complex environment can result in post detonation flow containing many scales of vortical motion, flow jetting and shear, as well as plume-surface interactions due to flow impingement and wall flows. In general, all these interactions can lead to highly turbulent flow fields even if the initial ambient conditions were quiescent. Thus, turbulent mixing can dominate initial mixing and impact the final afterburn. We conduct three-dimensional numerical simulations of the propagation of detonation resulting from metal-loaded (inert or reacting) explosives and analyze the afterburn process as well as the generation of multiple scales of mixing in the post detonation flow field. Impact of the detonation and post-detonation flow field on solid surface is also considered for a variety of initial conditions. Comparison with available data is carried out to demonstrate validity of the simulation method. Supported by Defense Threat Reduction Agency
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Swallowing difficulties for cerebellar stroke may recover beyond three years.
Périé, S; Wajeman, S; Vivant, R; St Guily, J L
1999-01-01
Swallowing disorders after stroke or skull base surgery can be life threatening. Although late recovery can occur, it remains poorly documented. We report a case of a 54-year-old woman with dysphagia resulting from a cerebellar stroke with hemorrhage that was evacuated through craniotomy. Swallowing difficulties were assessed by a videoendoscopic swallowing study. She presented with disruption of swallow initiation and impairment of the pharyngeal stage, resulting in hypopharyngeal stasis and penetration with aspiration. Supportive swallowing therapy was conducted with careful reeducation to assist initiation of the pharyngeal stage as well as development of compensatory postural technique. Initial improvement was very slow but became rapidly progressive from the 31st month after the stroke. By the 34th month, oral feeding was possible without aspiration. This case demonstrates that improvement in swallowing function can be expected even 3 years after stroke or skull base surgery. Determination of predictive factors for late functional recovery is of great importance and should be the focus of further investigation.
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NASA Astrophysics Data System (ADS)
Lemoine, F.
1997-09-01
Specific aspects of irradiated fuel result from the increasing retention of gaseous and volatile fission products with burnup, which, under overpower conditions, can lead to solid fuel pressurization and swelling causing severe PCMI (pellet clad mechanical interaction). In order to assess the reliability of high burnup fuel under RIAs, experimental programs have been initiated which have provided important data concerning the transient fission gas behavior and the clad loading mechanisms. The importance of the rim zone is demonstrated based on three experiments resulting in clad failure at low enthalpy, which are explained by energetic considerations. High gas release in non-failure tests with low energy deposition underlines the importance of grain boundary and porosity gas. Measured final releases are strongly correlated to the microstructure evolution, depending on energy deposition, pulse width, initial and refabricated fuel rod design. Observed helium release can also increase internal pressure and gives hints to the gas behavior understanding.
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Jiang, Wei; Chen, Yaxin; He, Xiaoxia; Hu, Shiwei; Li, Shijie; Liu, Yu
2018-01-15
The tyramine/glucose Maillard reaction was proposed as an emerging tool for tyramine reduction in a model system and two commercial soy sauce samples. The model system was composed of tyramine and glucose in buffer solutions with or without NaCl. The results showed that tyramine was reduced in the model system, and the reduction rate was affected by temperature, heating time, initial pH value, NaCl concentration, initial glucose concentration and initial tyramine concentration. Changes in fluorescence intensity and ultraviolet-visible (UV-vis) absorption spectra showed three stages of the Maillard reaction between tyramine and glucose. Cytotoxicity assay demonstrated that tyramine/glucose Maillard reaction products (MRPs) were significantly less toxic than that of tyramine (p<0.05). Moreover, tyramine concentration in soy sauce samples was significantly reduced when heated with the addition of glucose (p<0.05). Experimental results showed that the tyramine/glucose Maillard reaction is a promising method for tyramine reduction in foods. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Carboch, Jan; Süss, Vladimir; Kocib, Tomas
2014-01-01
Practicing with the use of a ball machine could handicap a player compared to playing against an actual opponent. Recent studies have shown some differences in swing timing and movement coordination, when a player faces a ball projection machine as opposed to a human opponent. We focused on the time of movement initiation and on stroke timing during returning tennis serves (simulated by a ball machine or by a real server). Receivers’ movements were measured on a tennis court. In spite of using a serving ball speed from 90 kph to 135 kph, results showed significant differences in movement initiation and backswing duration between serves received from a ball machine and serves received from a real server. Players had shorter movement initiation when they faced a ball machine. Backswing duration was longer for the group using a ball machine. That demonstrates different movement timing of tennis returns when players face a ball machine. Use of ball machines in tennis practice should be limited as it may disrupt stroke timing. Key points Players have shorter initial move time when they are facing the ball machine. Using the ball machine results in different swing timing and movement coordination. The use of the ball machine should be limited. PMID:24790483
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Carboch, Jan; Süss, Vladimir; Kocib, Tomas
2014-05-01
Practicing with the use of a ball machine could handicap a player compared to playing against an actual opponent. Recent studies have shown some differences in swing timing and movement coordination, when a player faces a ball projection machine as opposed to a human opponent. We focused on the time of movement initiation and on stroke timing during returning tennis serves (simulated by a ball machine or by a real server). Receivers' movements were measured on a tennis court. In spite of using a serving ball speed from 90 kph to 135 kph, results showed significant differences in movement initiation and backswing duration between serves received from a ball machine and serves received from a real server. Players had shorter movement initiation when they faced a ball machine. Backswing duration was longer for the group using a ball machine. That demonstrates different movement timing of tennis returns when players face a ball machine. Use of ball machines in tennis practice should be limited as it may disrupt stroke timing. Key pointsPlayers have shorter initial move time when they are facing the ball machine.Using the ball machine results in different swing timing and movement coordination.The use of the ball machine should be limited.
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Recent Results from the MAJORANA DEMONSTRATOR
NASA Astrophysics Data System (ADS)
Gilliss, T.; Alvis, S. I.; Arnquist, I. J.; Avignone, F. T.; Barabash, A. S.; Barton, C. J.; Bertrand, F. E.; Bode, T.; Brudanin, V.; Busch, M.; Buuck, M.; Caldwell, T. S.; Chan, Y.-D.; Christofferson, C. D.; Chu, P.-H.; Cuesta, C.; Detwiler, J. A.; Dunagan, C.; Efremenko, Yu; Ejiri, H.; Elliott, S. R.; Giovanetti, G. K.; Green, M. P.; Gruszko, J.; Guinn, I. S.; Guiseppe, V. E.; Haufe, C. R.; Hehn, L.; Henning, R.; Hoppe, E. W.; Howe, M. A.; Keeter, K. J.; Kidd, M. F.; Konovalov, S. I.; Kouzes, R. T.; Lopez, A. M.; Martin, R. D.; Massarczyk, R.; Meijer, S. J.; Mertens, S.; Myslik, J.; O’Shaughnessy, C.; Othman, G.; Pettus, W.; Poon, A. W. P.; Radford, D. C.; Rager, J.; Reine, A. L.; Rielage, K.; Robertson, R. G. H.; Ruof, N. W.; Shanks, B.; Shirchenko, M.; Suriano, A. M.; Tedeschi, D.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yu, C.-H.; Yumatov, V.; Zhitnikov, I.; Zhu, B. X.
The MAJORANA Collaboration has completed construction and is now operating an array of high purity Ge detectors searching for neutrinoless double-beta decay (0νββ) in 76Ge. The array, known as the MAJORANA DEMONSTRATOR, is comprised of 44 kg of Ge detectors (30 kg enriched to 88% in 76Ge) installed in an ultra-low background compact shield at the Sanford Underground Research Facility in Lead, South Dakota. The primary goal of the DEMONSTRATOR is to establish a low-background design that can be scaled to a next-generation tonne-scale experiment. This work reports initial background levels in the 0νββ region of interest. Also presented are recent physics results leveraging P-type point-contact detectors with sub-keV energy thresholds to search for physics beyond the Standard Model; first results from searches for bosonic dark matter, solar axions, Pauli exclusion principle violation, and electron decay have been published. Finally, this work discusses the proposed tonne-scale 76Ge 0νββ LEGEND experiment.
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Towards adjoint-based inversion of time-dependent mantle convection with nonlinear viscosity
NASA Astrophysics Data System (ADS)
Li, Dunzhu; Gurnis, Michael; Stadler, Georg
2017-04-01
We develop and study an adjoint-based inversion method for the simultaneous recovery of initial temperature conditions and viscosity parameters in time-dependent mantle convection from the current mantle temperature and historic plate motion. Based on a realistic rheological model with temperature-dependent and strain-rate-dependent viscosity, we formulate the inversion as a PDE-constrained optimization problem. The objective functional includes the misfit of surface velocity (plate motion) history, the misfit of the current mantle temperature, and a regularization for the uncertain initial condition. The gradient of this functional with respect to the initial temperature and the uncertain viscosity parameters is computed by solving the adjoint of the mantle convection equations. This gradient is used in a pre-conditioned quasi-Newton minimization algorithm. We study the prospects and limitations of the inversion, as well as the computational performance of the method using two synthetic problems, a sinking cylinder and a realistic subduction model. The subduction model is characterized by the migration of a ridge toward a trench whereby both plate motions and subduction evolve. The results demonstrate: (1) for known viscosity parameters, the initial temperature can be well recovered, as in previous initial condition-only inversions where the effective viscosity was given; (2) for known initial temperature, viscosity parameters can be recovered accurately, despite the existence of trade-offs due to ill-conditioning; (3) for the joint inversion of initial condition and viscosity parameters, initial condition and effective viscosity can be reasonably recovered, but the high dimension of the parameter space and the resulting ill-posedness may limit recovery of viscosity parameters.
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The Majorana Demonstrator Status and Preliminary Results
Yu, C. -H.; Alvis, S. I.; Arnquist, I. J.; ...
2018-01-01
The MAJORANA Collaboration is using an array of high-purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. Searches for neutrinoless double-beta decay are understood to be the only viable experimental method for testing the Majorana nature of the neutrino. Observation of this decay would imply violation of lepton number, that neutrinos are Majorana in nature, and provide information on the neutrino mass. The MAJORANA DEMONSTRATOR comprises 44.1 kg of p-type point-contact Ge detectors (29.7 kg enriched in 76Ge) surrounded by a low-background shield system. The experiment achieved a high efficiency of converting raw Ge material to detectors andmore » an unprecedented detector energy resolution of 2.5 keV FWHM at Q ββ. The MAJORANA collaboration began taking physics data in 2016. Here, this paper summarizes key construction aspects of the Demonstrator and shows preliminary results from initial data.« less
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The Majorana Demonstrator Status and Preliminary Results
NASA Astrophysics Data System (ADS)
Yu, C.-H.; Alvis, S. I.; Arnquist, I. J.; Avignone, F. T.; Barabash, A. S.; Barton, C. J.; Bertrand, F. E.; Bode, T.; Brudanin, V.; Busch, M.; Buuck, M.; Caldwell, T. S.; Chan, Y.-D.; Christofferson, C. D.; Chu, P.-H.; Cuesta, C.; Detwiler, J. A.; Dunagan, C.; Efremenko, Yu; Ejiri, H.; Elliott, S. R.; Gilliss, T.; Giovanetti, G. K.; Green, M.; Gruszko, J.; Guinn, I. S.; Guiseppe, V. E.; Haufe, C. R.; Hehn, L.; Henning, R.; Hoppe, E. W.; Howe, M. A.; Keeter, K. J.; Kidd, M. F.; Konovalov, S. I.; Kouzes, R. T.; Lopez, A. M.; Martin, R. D.; Massarczyk, R.; Meijer, S. J.; Mertens, S.; Myslik, J.; Othman, G.; Pettus, W.; Poon, A. W. P.; Radford, D. C.; Rager, J.; Reine, A. L.; Rielage, K.; Ruof, N. W.; Shanks, B.; Shirchenko, M.; Suriano, A. M.; Tedeschi, D.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yumatov, V.; Zhitnikov, I.; Zhu, B. Z.
2018-05-01
The MAJORANA Collaboration is using an array of high-purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. Searches for neutrinoless double-beta decay are understood to be the only viable experimental method for testing the Majorana nature of the neutrino. Observation of this decay would imply violation of lepton number, that neutrinos are Majorana in nature, and provide information on the neutrino mass. The MAJORANA DEMONSTRATOR comprises 44.1 kg of p-type point-contact Ge detectors (29.7 kg enriched in 76Ge) surrounded by a low-background shield system. The experiment achieved a high efficiency of converting raw Ge material to detectors and an unprecedented detector energy resolution of 2.5 keV FWHM at Qββ. The MAJORANA collaboration began taking physics data in 2016. This paper summarizes key construction aspects of the Demonstrator and shows preliminary results from initial data.
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The Majorana Demonstrator Status and Preliminary Results
DOE Office of Scientific and Technical Information (OSTI.GOV)
Yu, C. -H.; Alvis, S. I.; Arnquist, I. J.
The MAJORANA Collaboration is using an array of high-purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. Searches for neutrinoless double-beta decay are understood to be the only viable experimental method for testing the Majorana nature of the neutrino. Observation of this decay would imply violation of lepton number, that neutrinos are Majorana in nature, and provide information on the neutrino mass. The MAJORANA DEMONSTRATOR comprises 44.1 kg of p-type point-contact Ge detectors (29.7 kg enriched in 76Ge) surrounded by a low-background shield system. The experiment achieved a high efficiency of converting raw Ge material to detectors andmore » an unprecedented detector energy resolution of 2.5 keV FWHM at Q ββ. The MAJORANA collaboration began taking physics data in 2016. Here, this paper summarizes key construction aspects of the Demonstrator and shows preliminary results from initial data.« less
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Absence of periodic orbits in digital memcomputing machines with solutions
NASA Astrophysics Data System (ADS)
Di Ventra, Massimiliano; Traversa, Fabio L.
2017-10-01
In Traversa and Di Ventra [Chaos 27, 023107 (2017)] we argued, without proof, that if the non-linear dynamical systems with memory describing the class of digital memcomputing machines (DMMs) have equilibrium points, then no periodic orbits can emerge. In fact, the proof of such a statement is a simple corollary of a theorem already demonstrated in Traversa and Di Ventra [Chaos 27, 023107 (2017)]. Here, we point out how to derive such a conclusion. Incidentally, the same demonstration implies absence of chaos, a result we have already demonstrated in Di Ventra and Traversa [Phys. Lett. A 381, 3255 (2017)] using topology. These results, together with those in Traversa and Di Ventra [Chaos 27, 023107 (2017)], guarantee that if the Boolean problem the DMMs are designed to solve has a solution, the system will always find it, irrespective of the initial conditions.
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Evidence accumulation as a model for lexical selection.
Anders, R; Riès, S; van Maanen, L; Alario, F X
2015-11-01
We propose and demonstrate evidence accumulation as a plausible theoretical and/or empirical model for the lexical selection process of lexical retrieval. A number of current psycholinguistic theories consider lexical selection as a process related to selecting a lexical target from a number of alternatives, which each have varying activations (or signal supports), that are largely resultant of an initial stimulus recognition. We thoroughly present a case for how such a process may be theoretically explained by the evidence accumulation paradigm, and we demonstrate how this paradigm can be directly related or combined with conventional psycholinguistic theory and their simulatory instantiations (generally, neural network models). Then with a demonstrative application on a large new real data set, we establish how the empirical evidence accumulation approach is able to provide parameter results that are informative to leading psycholinguistic theory, and that motivate future theoretical development. Copyright © 2015 Elsevier Inc. All rights reserved.
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Contamination control and assay results for the Majorana Demonstrator ultra clean components
NASA Astrophysics Data System (ADS)
Christofferson, C. D.; Abgrall, N.; Alvis, S. I.; Arnquist, I. J.; Avignone, F. T.; Barabash, A. S.; Barton, C. J.; Bertrand, F. E.; Bode, T.; Bradley, A. W.; Brudanin, V.; Busch, M.; Buuck, M.; Caldwell, T. S.; Chan, Y.-D.; Chu, P.-H.; Cuesta, C.; Detwiler, J. A.; Dunagan, C.; Efremenko, Yu.; Ejiri, H.; Elliott, S. R.; Gilliss, T.; Giovanetti, G. K.; Green, M. P.; Gruszko, J.; Guinn, I. S.; Guiseppe, V. E.; Haufe, C. R.; Hehn, L.; Henning, R.; Hoppe, E. W.; Howe, M. A.; Keeter, K. J.; Kidd, M. F.; Konovalov, S. I.; Kouzes, R. T.; Lopez, A. M.; Martin, R. D.; Massarczyk, R.; Meijer, S. J.; Mertens, S.; Myslik, J.; O'Shaughnessy, C.; Othman, G.; Poon, A. W. P.; Radford, D. C.; Rager, J.; Reine, A. L.; Rielage, K.; Robertson, R. G. H.; Rouf, N. W.; Shanks, B.; Shirchenko, M.; Suriano, A. M.; Tedeschi, D.; Trimble, J. E.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yu, C.-H.; Yumatov, V.; Zhitnikov, I.; Zhu, B. X.
2018-01-01
The Majorana Demonstrator is a neutrinoless double beta decay experiment utilizing enriched Ge-76 detectors in 2 separate modules inside of a common solid shield at the Sanford Underground Research Facility. The Demonstrator has utilized world leading assay sensitivities to develop clean materials and processes for producing ultra-pure copper and plastic components. This experiment is now operating, and initial data provide new insights into the success of cleaning and processing. Post production copper assays after the completion of Module 1 showed an increase in U and Th contamination in finished parts compared to starting bulk material. A revised cleaning method and additional round of surface contamination studies prior to Module 2 construction have provided evidence that more rigorous process control can reduce surface contamination. This article describes the assay results and discuss further studies to take advantage of assay capabilities for the purpose of maintaining ultra clean fabrication and process design.
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Constitutive modeling for isotropic materials (HOST)
NASA Technical Reports Server (NTRS)
Lindholm, Ulric S.; Chan, Kwai S.; Bodner, S. R.; Weber, R. M.; Walker, K. P.; Cassenti, B. N.
1984-01-01
The results of the first year of work on a program to validate unified constitutive models for isotropic materials utilized in high temperature regions of gas turbine engines and to demonstrate their usefulness in computing stress-strain-time-temperature histories in complex three-dimensional structural components. The unified theories combine all inelastic strain-rate components in a single term avoiding, for example, treating plasticity and creep as separate response phenomena. An extensive review of existing unified theories is given and numerical methods for integrating these stiff time-temperature-dependent constitutive equations are discussed. Two particular models, those developed by Bodner and Partom and by Walker, were selected for more detailed development and evaluation against experimental tensile, creep and cyclic strain tests on specimens of a cast nickel base alloy, B19000+Hf. Initial results comparing computed and test results for tensile and cyclic straining for temperature from ambient to 982 C and strain rates from 10(exp-7) 10(exp-3) s(exp-1) are given. Some preliminary date correlations are presented also for highly non-proportional biaxial loading which demonstrate an increase in biaxial cyclic hardening rate over uniaxial or proportional loading conditions. Initial work has begun on the implementation of both constitutive models in the MARC finite element computer code.
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Serious Non-AIDS Conditions in HIV: Benefit of Early ART.
Lundgren, Jens D; Borges, Alvaro H; Neaton, James D
2018-04-01
Optimal control of HIV can be achieved by early diagnosis followed by the initiation of antiretroviral therapy (ART). Two large randomised trials (TEMPRANO and START) have recently been published documenting the clinical benefits to HIV-positive adults of early ART initiation. Main findings are reviewed with a focus on serious non-AIDS (SNA) conditions. Data from the two trials demonstrated that initiating ART early in the course of HIV infection resulted in marked reductions in the risk of opportunistic diseases and invasive bacterial infections. This indicates that HIV causes immune impairment in early infection that is remedied by controlling viral replication. Intriguingly, in START, a marked reduction in risk of cancers, both infection-related and unrelated types of cancers, was observed. Like the findings for opportunistic infections, this anti-cancer effect of early ART shows how the immune system influences important pro-oncogenic processes. In START, there was also some evidence suggesting that early ART initiation preserved kidney function, although the clinical consequence of this remains unclear. Conversely, while no adverse effects were evident, the trials did not demonstrate a clear effect on metabolic-related disease outcomes, pulmonary disease, or neurocognitive function. HIV causes immune impairment soon after acquisition of infection. ART reverses this harm at least partially. The biological nature of the immune impairment needs further elucidation, as well as mechanisms and clinical impact of innate immune activation. Based on the findings from TEMPRANO and START, and because ART lowers the risk of onward transmission, ART initiation should be offered to all persons following their diagnosis of HIV.
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Development of Gold Standard Ion-Selective Electrode-Based Methods for Fluoride Analysis
Martínez-Mier, E.A.; Cury, J.A.; Heilman, J.R.; Katz, B.P.; Levy, S.M.; Li, Y.; Maguire, A.; Margineda, J.; O’Mullane, D.; Phantumvanit, P.; Soto-Rojas, A.E.; Stookey, G.K.; Villa, A.; Wefel, J.S.; Whelton, H.; Whitford, G.M.; Zero, D.T.; Zhang, W.; Zohouri, V.
2011-01-01
Background/Aims: Currently available techniques for fluoride analysis are not standardized. Therefore, this study was designed to develop standardized methods for analyzing fluoride in biological and nonbiological samples used for dental research. Methods A group of nine laboratories analyzed a set of standardized samples for fluoride concentration using their own methods. The group then reviewed existing analytical techniques for fluoride analysis, identified inconsistencies in the use of these techniques and conducted testing to resolve differences. Based on the results of the testing undertaken to define the best approaches for the analysis, the group developed recommendations for direct and microdiffusion methods using the fluoride ion-selective electrode. Results Initial results demonstrated that there was no consensus regarding the choice of analytical techniques for different types of samples. Although for several types of samples, the results of the fluoride analyses were similar among some laboratories, greater differences were observed for saliva, food and beverage samples. In spite of these initial differences, precise and true values of fluoride concentration, as well as smaller differences between laboratories, were obtained once the standardized methodologies were used. Intraclass correlation coefficients ranged from 0.90 to 0.93, for the analysis of a certified reference material, using the standardized methodologies. Conclusion The results of this study demonstrate that the development and use of standardized protocols for F analysis significantly decreased differences among laboratories and resulted in more precise and true values. PMID:21160184
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Makan, Abdelhadi; Assobhei, Omar; Mountadar, Mohammed
2013-01-03
This study aimed to evaluate the effect of initial moisture content on the in-vessel composting under air pressure of organic fraction of municipal solid waste in Morocco in terms of internal temperature, produced gases quantity, organic matter conversion rate, and the quality of the final composts.For this purpose, in-vessel bioreactor was designed and used to evaluate both appropriate initial air pressure and appropriate initial moisture content for the composting process. Moreover, 5 experiments were carried out within initial moisture content of 55%, 65%, 70%, 75% and 85%. The initial air pressure and the initial moisture content of the mixture showed a significant effect on the aerobic composting. The experimental results demonstrated that for composting organic waste, relatively high moisture contents are better at achieving higher temperatures and retaining them for longer times.This study suggested that an initial moisture content of around 75%, under 0.6 bar, can be considered as being suitable for efficient composting of organic fraction of municipal solid waste. These last conditions, allowed maximum value of temperature and final composting product with good physicochemical properties as well as higher organic matter degradation and higher gas production. Moreover, final compost obtained showed good maturity levels and can be used for agricultural applications.
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NASA Astrophysics Data System (ADS)
Pollock, N. M.; Brand, B. D.; Roche, O.
2017-12-01
The macroscopic processes that control the behavior of pyroclastic density currents (PDCs) include the transportation and deposition of flow particles, entrainment of air, and interaction with topography. However, recent field studies demonstrate that substrate erosion by PDCs is also pervasive. Furthermore, analogue experiments suggest that erosion can increase flow runout distance up to 50%. We present the results from a series of analogue flume experiments on both non-fluidized and initially gas fluidized (i.e. high pore fluid pressure) granular flows. The experiments are designed to explore the controls on erosion initiation and intensity, and how erosion affects flow dynamics. A range of initial conditions allow us to explore how the angle of the bed (0°-20°) and diameter of substrate particles (40 to 700 μm) affect the onset of erosion. The experiments also explore how erosion, once initiated, affects the behavior of the flow in terms of velocity and runout distance. We observe that fluidized flows have increased runout distances of 50-300% relative to non-fluidized flows with the same initial conditions. Fluidized flows that travel over substrates composed of 40 μm particles consistently experience the largest increase in runout distance relative to non-fluidized flows, while flows over substrates of 80 μm particles experience the lowest increase. Erosion occurs for all experimental configurations in both non-fluidized and fluidized flows; however, the intensity of erosion varies widely, from small, millimeter-scale erosional features to decimeter sized wave-like features. Fluidized flows consistently show more intense erosion than non-fluidized flows, suggesting that the fluid-like behavior of these flows allows for efficient mixing between flow and substrate particles. These experiments demonstrate that erosion is a pervasive process for fluidized granular flows and that intense erosion is associated with increased flow runout distances. These results improve our understanding of the role of fluidization in erosion processes, what controls when PDCs become erosional, and how that erosion can alter flow behavior. To accurately model and predict hazards associated with PDCs, we must better understand erosional processes as they relate to these dangerous volcanic phenomena.
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NASA Technical Reports Server (NTRS)
Morehead, R. L.; Atwell, M. J.; Melcher, J. C.; Hurlbert, E. A.
2016-01-01
A prototype cold helium active pressurization system was incorporated into an existing liquid oxygen (LOX) / liquid methane (LCH4) prototype planetary lander and hot-fire tested to collect vehicle-level performance data. Results from this hot-fire test series were used to validate integrated models of the vehicle helium and propulsion systems and demonstrate system effectiveness for a throttling lander. Pressurization systems vary greatly in complexity and efficiency between vehicles, so a pressurization performance metric was also developed as a means to compare different active pressurization schemes. This implementation of an active repress system is an initial sizing draft. Refined implementations will be tested in the future, improving the general knowledge base for a cryogenic lander-based cold helium system.
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Hamacher, Michael; Gröttrup, Bernd; Eisenacher, Martin; Marcus, Katrin; Park, Young Mok; Meyer, Helmut E; Kwon, Kyung-Hoon; Stephan, Christian
2011-01-01
Several projects were initiated by the Human Proteome Organisation (HUPO) focusing on the proteome analysis of distinct human organs. The initiative dedicated to the brain, its development and correlated diseases is the HUPO Brain Proteome Project (HUPO BPP). An objective data submission, storage, and reprocessing strategy have been established with the help of the results gained in a pilot study phase and within subsequent studies. The bioinformatic relevance of the data is drawn from the inter-laboratory comparisons as well as from the recalculation of all data sets submitted by the different groups. In the following, results of the single groups as well as the centralised reprocessing effort are summarised, demonstrating the added-value of this concerted work.
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Adjustable typography: an approach to enhancing low vision text accessibility.
Arditi, Aries
2004-04-15
Millions of people have low vision, a disability condition caused by uncorrectable or partially correctable disorders of the eye. The primary goal of low vision rehabilitation is increasing access to printed material. This paper describes how adjustable typography, a computer graphic approach to enhancing text accessibility, can play a role in this process, by allowing visually-impaired users to customize fonts to maximize legibility according to their own visual needs. Prototype software and initial testing of the concept is described. The results show that visually-impaired users tend to produce a variety of very distinct fonts, and that the adjustment process results in greatly enhanced legibility. But this initial testing has not yet demonstrated increases in legibility over and above the legibility of highly legible standard fonts such as Times New Roman.
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Cascade heterogeneous face sketch-photo synthesis via dual-scale Markov Network
NASA Astrophysics Data System (ADS)
Yao, Saisai; Chen, Zhenxue; Jia, Yunyi; Liu, Chengyun
2018-03-01
Heterogeneous face sketch-photo synthesis is an important and challenging task in computer vision, which has widely applied in law enforcement and digital entertainment. According to the different synthesis results based on different scales, this paper proposes a cascade sketch-photo synthesis method via dual-scale Markov Network. Firstly, Markov Network with larger scale is used to synthesise the initial sketches and the local vertical and horizontal neighbour search (LVHNS) method is used to search for the neighbour patches of test patches in training set. Then, the initial sketches and test photos are jointly entered into smaller scale Markov Network. Finally, the fine sketches are obtained after cascade synthesis process. Extensive experimental results on various databases demonstrate the superiority of the proposed method compared with several state-of-the-art methods.
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Bolin, Jocelyn Holden; Finch, W Holmes
2014-01-01
Statistical classification of phenomena into observed groups is very common in the social and behavioral sciences. Statistical classification methods, however, are affected by the characteristics of the data under study. Statistical classification can be further complicated by initial misclassification of the observed groups. The purpose of this study is to investigate the impact of initial training data misclassification on several statistical classification and data mining techniques. Misclassification conditions in the three group case will be simulated and results will be presented in terms of overall as well as subgroup classification accuracy. Results show decreased classification accuracy as sample size, group separation and group size ratio decrease and as misclassification percentage increases with random forests demonstrating the highest accuracy across conditions.
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Necessity of guides in pedestrian emergency evacuation
NASA Astrophysics Data System (ADS)
Yang, Xiaoxia; Dong, Hairong; Yao, Xiuming; Sun, Xubin; Wang, Qianling; Zhou, Min
2016-01-01
The role of guide who is in charge of leading pedestrians to evacuate in the case of emergency plays a critical role for the uninformed people. This paper first investigates the influence of mass behavior on evacuation dynamics and mainly focuses on the guided evacuation dynamics. In the extended crowd model proposed in this paper, individualistic behavior, herding behavior and environment influence are all considered for pedestrians who are not informed by the guide. According to the simulation results, herding behavior makes more pedestrians evacuate from the room in the same period of time. Besides, guided crowd demonstrates the same behavior of group dynamics which is characterized by gathering, conflicts and balance. Moreover, simulation results indicate guides with appropriate initial positions and quantity are more conducive to evacuation under a moderate initial density of pedestrians.
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Angell, Trevor E; Vyas, Chirag M; Barletta, Justine A; Cibas, Edmund S; Cho, Nancy L; Doherty, Gerard M; Gawande, Atul A; Howitt, Brooke E; Krane, Jeffrey F; Marqusee, Ellen; Strickland, Kyle C; Alexander, Erik K; Moore, Francis D; Nehs, Matthew A
2018-05-01
Diagnostic hemithyroidectomy (HT) is the most widely recommended surgical procedure for a nodule with indeterminate cytology; however, additional details may make initial total thyroidectomy (TT) preferable. We sought to identify patient-specific factors (PSFs) associated with initial TT in patients with indeterminate thyroid nodules. Retrospective analysis of all patients with a thyroid nodule ≥ 1 cm and initial cytology of atypia of undetermined significance or suspicious for follicular neoplasm between 2012 and 2015 who underwent thyroidectomy. Medical records were reviewed for patient demographics, neck symptoms, nodule size, cytology, molecular test results, final histopathology, and additional PSFs influencing surgical management. Variables were analyzed to determine associations with the use of initial TT. Logistic regression analyses were performed to identify independent associations. Of 325 included patients, 182/325 (56.0%) had HT and 143/325 (44.0%) had TT. While patient age and sex, nodule size, and cytology result were not associated with initial treatment, five PSFs were associated with initial TT (p < 0.0001). These included contralateral nodules, hypothyroidism, fluorodeoxyglucose avidity on positron emission tomography scan, family history of thyroid cancer, and increased surgical risk. At least one PSF was present in 126/143 (88.1%) TT patients versus 47/182 (25.8%) HT patients (p < 0.0001). Multivariate logistic regression analysis demonstrated that these variables were the strongest independent predictor of TT (odds ratio 45.93, 95% confidence interval 18.80-112.23, p < 0.001). When surgical management of an indeterminate cytology thyroid nodule was performed, several PSFs were associated with a preference by surgeons and patients for initial TT, which may be useful to consider in making decisions on initial operative extent.
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Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I demonstrate initial compliance with the emission limitations if I monitor fermenter exhaust? 63.2165 Section 63.2165 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 12 2010-07-01 2010-07-01 true How do I demonstrate initial compliance with the emission limitations if I monitor fermenter exhaust? 63.2165 Section 63.2165 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 12 2011-07-01 2009-07-01 true How do I demonstrate initial compliance with the emission limitations if I monitor brew ethanol? 63.2166 Section 63.2166 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... must I use to demonstrate initial compliance with the emission limits for particulate matter and PM10... compliance with the emission limits for particulate matter and PM10? (a) You must conduct each performance... determine compliance with the applicable emission limits for particulate matter in Table 1 to this subpart...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... must I use to demonstrate initial compliance with the emission limits for particulate matter and PM10... compliance with the emission limits for particulate matter and PM10? (a) You must conduct each performance... determine compliance with the applicable emission limits for particulate matter in Table 1 to this subpart...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... Standards for Hazardous Air Pollutants: Site Remediation Tanks § 63.7896 How do I demonstrate initial...) for the tanks to be used for your site remediation. (2) You have determined, according to the procedures in § 63.7944, and recorded the maximum HAP vapor pressure of the remediation material placed in...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... Standards for Hazardous Air Pollutants: Site Remediation Containers § 63.7901 How do I demonstrate initial... specified in § 63.7990 for the containers to be used for your site remediation. (2) You have determined and recorded the maximum vapor pressure or total organic concentration for the remediation material placed in...
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40 CFR 63.8234 - What equations and procedures must I use for the initial compliance demonstration?
Code of Federal Regulations, 2010 CFR
2010-07-01
... What equations and procedures must I use for the initial compliance demonstration? (a) By-product... Megagram of chlorine production (g Hg/Mg Cl2) of chlorine produced from all by-product hydrogen streams and...) Determine the mercury emission rate for each test run in grams per day for each by-product hydrogen stream...
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UAS Integration into the NAS: HSI Full Mission Simulation Preliminary Results
NASA Technical Reports Server (NTRS)
Shively, Jay; Fern, Lisa; Rorie, Conrad
2014-01-01
The goal of the Full Mission Sim was to examine the effects of different command and control interfaces on UAS pilots' ability to respond to ATC commands and traffic advisories. Results suggest that higher levels of automation (i.e., waypoint-to-waypoint control interfaces) lead to longer initial response times and longer edit times. The findings demonstrate the importance of providing pilots with interfaces that facilitate their ability to get back "in the loop."
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1987-08-01
conflicts between the facility and local standards, and to evaluate the probability of conflict resulting from any planned expansions. 2-2 Visual Resources...on staffing and housing for the facility itself is contained in Table 2-7. Additional data on the socio - economic background of Ebeye, including...resources, noise, and socio - economics. As a result of that evaluation, consequences vere assigned to one of three categories: insignificant, mitigable, or
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Efficacy of Single and Combined Antibiotic Treatments of Anthrax in Rabbits.
Weiss, Shay; Altboum, Zeev; Glinert, Itai; Schlomovitz, Josef; Sittner, Assa; Bar-David, Elad; Kobiler, David; Levy, Haim
2015-12-01
Respiratory anthrax is a fatal disease in the absence of early treatment with antibiotics. Rabbits are highly susceptible to infection with Bacillus anthracis spores by intranasal instillation, succumbing within 2 to 4 days postinfection. This study aims to test the efficiency of antibiotic therapy to treat systemic anthrax in this relevant animal model. Delaying the initiation of antibiotic administration to more than 24 h postinfection resulted in animals with systemic anthrax in various degrees of bacteremia and toxemia. As the onset of symptoms in humans was reported to start on days 1 to 7 postexposure, delaying the initiation of treatment by 24 to 48 h (time frame for mass distribution of antibiotics) may result in sick populations. We evaluated the efficacy of antibiotic administration as a function of bacteremia levels at the time of treatment initiation. Here we compare the efficacy of treatment with clarithromycin, amoxicillin-clavulanic acid (Augmentin), imipenem, vancomycin, rifampin, and linezolid to the previously reported efficacy of doxycycline and ciprofloxacin. We demonstrate that treatment with amoxicillin-clavulanic acid, imipenem, vancomycin, and linezolid were as effective as doxycycline and ciprofloxacin, curing rabbits exhibiting bacteremia levels of up to 10(5) CFU/ml. Clarithromycin and rifampin were shown to be effective only as a postexposure prophylactic treatment but failed to treat the systemic (bacteremic) phase of anthrax. Furthermore, we evaluate the contribution of combined treatment of clindamycin and ciprofloxacin, which demonstrated improvement in efficacy compared to ciprofloxacin alone. Copyright © 2015, American Society for Microbiology. All Rights Reserved.
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Deng, Jie; Larson, Andrew C.
2010-01-01
Objectives To test the feasibility of combining inner-volume imaging (IVI) techniques with conventional multishot periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) techniques for targeted-PROPELLER magnetic resonance imaging. Materials and Methods Perpendicular section-selective gradients for spatially selective excitation and refocusing RF pulses were applied to limit the refocused field-of-view (FOV) along the phase-encoding direction for each rectangular blade image. We performed comparison studies in phantoms and normal volunteers by using targeted-PROPELLER methods for a wide range of imaging applications that commonly use turbo-spin-echo (TSE) approaches (brain, abdominal, vessel wall, cardiac). Results In these initial studies, we demonstrated the feasibility of using targeted-PROPELLER approaches to limit the imaging FOV thereby reducing the number of blades or permitting increased spatial resolution without commensurate increases in scan time. Both phantom and in vivo motion studies demonstrated the potential for more robust regional self-navigated motion correction compared with conventional full FOV PROPELLER methods. Conclusion We demonstrated that the reduced FOV targeted-PROPELLER technique offers the potential for reducing imaging time, increasing spatial resolution, and targeting specific areas for robust regional motion correction. PMID:19465860
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Electrolysis Performance Improvement Concept Study (EPICS) Flight Experiment-Reflight
NASA Technical Reports Server (NTRS)
Schubert, F. H.
1997-01-01
The Electrolysis Performance Improvement Concept Study (EPICS) is a flight experiment to demonstrate and validate in a microgravity environment the Static Feed Electrolyzer (SFE) concept which was selected for the use aboard the International Space Station (ISS) for oxygen (O2) generation. It also is to investigate the impact of microgravity on electrochemical cell performance. Electrochemical cells are important to the space program because they provide an efficient means of generating O2 and hydrogen (H2) in space. Oxygen and H2 are essential not only for the survival of humans in space but also for the efficient and economical operation of various space systems. Electrochemical cells can reduce the mass, volume and logistical penalties associated with resupply and storage by generating and/or consuming these gases in space. An initial flight of the EPICS was conducted aboard STS-69 from September 7 to 8, 1995. A temperature sensor characteristics shift and a missing line of software code resulted in only partial success of this initial flight. Based on the review and recommendations of a National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) review team a reflight activity was initiated to obtain the remaining desired results, not achieved during the initial flight.
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Very High Cycle Fatigue Behavior of a Directionally Solidified Ni-Base Superalloy DZ4
Nie, Baohua; Zhao, Zihua; Liu, Shu; Chen, Dongchu; Ouyang, Yongzhong; Hu, Zhudong; Fan, Touwen; Sun, Haibo
2018-01-01
The effect of casting pores on the very high cycle fatigue (VHCF) behavior of a directionally solidified (DS) Ni-base superalloy DZ4 is investigated. Casting and hot isostatic pressing (HIP) specimens were subjected to very high cycle fatigue loading in an ambient atmosphere. The results demonstrated that the continuously descending S-N curves were exhibited for both the casting and HIP specimens. Due to the elimination of the casting pores, the HIP samples had better fatigue properties than the casting samples. The subsurface crack initiated from the casting pore in the casting specimens at low stress amplitudes, whereas fatigue crack initiated from crystallographic facet decohesion for the HIP specimens. When considering the casting pores as initial cracks, there exists a critical stress intensity threshold ranged from 1.1 to 1.3 MPam, below which fatigue cracks may not initiate from the casting pores. Furthermore, the effect of the casting pores on the fatigue limit is estimated based on a modified El Haddad model, which is in good agreement with the experimental results. Fatigue life for both the casting and HIP specimens is well predicted using the Fatigue Indicator Parameter (FIP) model. PMID:29320429
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Monitoring wetlands change using LANDSAT data
NASA Technical Reports Server (NTRS)
Hardin, D. L.
1981-01-01
A wetlands monitoring study was initiated as part of Delaware's LANDSAT applications demonstration project. Classifications of digital data are conducted in an effort to determine the location and acreage of wetlands loss or gain, species conversion, and application for the inventory and typing of freshwater wetlands. A multi-seasonal approach is employed to compare data from two different years. Unsupervised classifications were conducted for two of the four dates examined. Initial results indicate the multi-seasonal approach allows much better separation of wetland types for both tidal and non-tidal wetlands than either season alone. Change detection is possible but generally misses the small acreages now impacted by man.
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Redundant information from thermal illumination: quantum Darwinism in scattered photons
NASA Astrophysics Data System (ADS)
Jess Riedel, C.; Zurek, Wojciech H.
2011-07-01
We study quantum Darwinism, the redundant recording of information about the preferred states of a decohering system by its environment, for an object illuminated by a blackbody. We calculate the quantum mutual information between the object and its photon environment for blackbodies that cover an arbitrary section of the sky. In particular, we demonstrate that more extended sources have a reduced ability to create redundant information about the system, in agreement with previous evidence that initial mixedness of an environment slows—but does not stop—the production of records. We also show that the qualitative results are robust for more general initial states of the system.
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An Equation of State for Foamed Divinylbenzene (DVB) Based on Multi-Shock Response
NASA Astrophysics Data System (ADS)
Aslam, Tariq; Schroen, Diana; Gustavsen, Richard; Bartram, Brian
2013-06-01
The methodology for making foamed Divinylbenzene (DVB) is described. For a variety of initial densities, foamed DVB is examined through multi-shock compression and release experiments. Results from multi-shock experiments on LANL's 2-stage gas gun will be presented. A simple conservative Lagrangian numerical scheme, utilizing total-variation-diminishing interpolation and an approximate Riemann solver, will be presented as well as the methodology of calibration. It has been previously demonstrated that a single Mie-Gruneisen fitting form can replicate foam multi-shock compression response at a variety of initial densities; such a methodology will be presented for foamed DVB.
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Marketing physical activity: lessons learned from a statewide media campaign.
Peterson, Michael; Abraham, Avron; Waterfield, Allan
2005-10-01
Steps taken to create, implement, and initially assess a statewide physical activity social marketing campaign targeted to 18-to 30-year-olds are presented. Included is a summary demonstration of the application of the associative group analysis in formative market research and message development. Initial postcampaign questionnaire (n = 363) results indicated that 39.1% of respondents had seen the television ad, of which 31.2% indicated they intended to be more active, and 62.5% of respondents had been exposed to either the television or outdoor media ads. Lessons learned through the social marketing process including media channel effectiveness, message development and assessment, and marketing firm relationships are provided.
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Improved Fractal Space Filling Curves Hybrid Optimization Algorithm for Vehicle Routing Problem.
Yue, Yi-xiang; Zhang, Tong; Yue, Qun-xing
2015-01-01
Vehicle Routing Problem (VRP) is one of the key issues in optimization of modern logistics system. In this paper, a modified VRP model with hard time window is established and a Hybrid Optimization Algorithm (HOA) based on Fractal Space Filling Curves (SFC) method and Genetic Algorithm (GA) is introduced. By incorporating the proposed algorithm, SFC method can find an initial and feasible solution very fast; GA is used to improve the initial solution. Thereafter, experimental software was developed and a large number of experimental computations from Solomon's benchmark have been studied. The experimental results demonstrate the feasibility and effectiveness of the HOA.
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Discontinuously Stiffened Composite Panel under Compressive Loading
NASA Technical Reports Server (NTRS)
Minnetyan, Levon; Rivers, James M.; Chamis, Christos C.; Murthy, Pappu L. N.
1995-01-01
The design of composite structures requires an evaluation of their safety and durability under service loads and possible overload conditions. This paper presents a computational tool that has been developed to examine the response of stiffened composite panels via the simulation of damage initiation, growth, accumulation, progression, and propagation to structural fracture or collapse. The structural durability of a composite panel with a discontinuous stiffener is investigated under compressive loading induced by the gradual displacement of an end support. Results indicate damage initiation and progression to have significant effects on structural behavior under loading. Utilization of an integrated computer code for structural durability assessment is demonstrated.
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Improved Fractal Space Filling Curves Hybrid Optimization Algorithm for Vehicle Routing Problem
Yue, Yi-xiang; Zhang, Tong; Yue, Qun-xing
2015-01-01
Vehicle Routing Problem (VRP) is one of the key issues in optimization of modern logistics system. In this paper, a modified VRP model with hard time window is established and a Hybrid Optimization Algorithm (HOA) based on Fractal Space Filling Curves (SFC) method and Genetic Algorithm (GA) is introduced. By incorporating the proposed algorithm, SFC method can find an initial and feasible solution very fast; GA is used to improve the initial solution. Thereafter, experimental software was developed and a large number of experimental computations from Solomon's benchmark have been studied. The experimental results demonstrate the feasibility and effectiveness of the HOA. PMID:26167171
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Scattering of water from the glycerol liquid-vacuum interface
NASA Technical Reports Server (NTRS)
Benjamin, I.; Wilson, M. A.; Pohorille, A.; Nathanson, G. M.
1995-01-01
Molecular dynamics calculations of the scattering of D2O from the glycerol surface at different collision energies are reported. The results for the trapping probabilities and energy transfer are in good agreement with experiments. The calculations demonstrate that the strong attractive forces between these two strongly hydrogen bonding molecules have only a minor effect on the initial collision dynamics. The trapping probability is influenced to a significant extent by the repulsive hard sphere-like initial encounter with the corrugated surface and, only at a later stage, by the efficiency of energy flow in the multiple interactions between the water and the surface molecules.
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Suicide case with multiple injuries with sharp objects.
Черняк, Валентина В; Девяткин, Александр Е; Мустафина, Галия М; Никифоров, Артём Г
The work of forensic - medical expert examination of the corpse at the place of its discovery and further research in the morgue often there are certain difficulties associated with the solution of a number of issues, including the establishment of a kind of death. Bringing the case demonstrates that, during the initial examination of the corpse to the place of its discovery the presence of multiple injuries on the body of a different nature, as a rule, initially suggest investigators to suspect that the murder occurred. But further questioning around him lately those studying survey data and scene study results allowed the corpse to make objective conclusions.
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Knowledge representation into Ada parallel processing
NASA Technical Reports Server (NTRS)
Masotto, Tom; Babikyan, Carol; Harper, Richard
1990-01-01
The Knowledge Representation into Ada Parallel Processing project is a joint NASA and Air Force funded project to demonstrate the execution of intelligent systems in Ada on the Charles Stark Draper Laboratory fault-tolerant parallel processor (FTPP). Two applications were demonstrated - a portion of the adaptive tactical navigator and a real time controller. Both systems are implemented as Activation Framework Objects on the Activation Framework intelligent scheduling mechanism developed by Worcester Polytechnic Institute. The implementations, results of performance analyses showing speedup due to parallelism and initial efficiency improvements are detailed and further areas for performance improvements are suggested.
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Compliant Task Execution and Learning for Safe Mixed-Initiative Human-Robot Operations
NASA Technical Reports Server (NTRS)
Dong, Shuonan; Conrad, Patrick R.; Shah, Julie A.; Williams, Brian C.; Mittman, David S.; Ingham, Michel D.; Verma, Vandana
2011-01-01
We introduce a novel task execution capability that enhances the ability of in-situ crew members to function independently from Earth by enabling safe and efficient interaction with automated systems. This task execution capability provides the ability to (1) map goal-directed commands from humans into safe, compliant, automated actions, (2) quickly and safely respond to human commands and actions during task execution, and (3) specify complex motions through teaching by demonstration. Our results are applicable to future surface robotic systems, and we have demonstrated these capabilities on JPL's All-Terrain Hex-Limbed Extra-Terrestrial Explorer (ATHLETE) robot.
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A demonstrative model of a lunar base simulation on a personal computer
NASA Technical Reports Server (NTRS)
1985-01-01
The initial demonstration model of a lunar base simulation is described. This initial model was developed on the personal computer level to demonstrate feasibility and technique before proceeding to a larger computer-based model. Lotus Symphony Version 1.1 software was used to base the demonstration model on an personal computer with an MS-DOS operating system. The personal computer-based model determined the applicability of lunar base modeling techniques developed at an LSPI/NASA workshop. In addition, the personnal computer-based demonstration model defined a modeling structure that could be employed on a larger, more comprehensive VAX-based lunar base simulation. Refinement of this personal computer model and the development of a VAX-based model is planned in the near future.
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Preferences for the Return of Individual Results From Research on Pediatric Biobank Samples.
Christensen, Kurt D; Savage, Sarah K; Huntington, Noelle L; Weitzman, Elissa R; Ziniel, Sonja I; Bacon, Phoebe L; Cacioppo, Cara N; Green, Robert C; Holm, Ingrid A
2017-04-01
Discussions about disclosing individual genetic research results include calls to consider participants' preferences. In this study, parents of Boston Children's Hospital patients set preferences for disclosure based on disease preventability and severity, and could exclude mental health, developmental, childhood degenerative, and adult-onset disorders. Participants reviewed hypothetical reports and reset preferences, if desired. Among 661 participants who initially wanted all results (64%), 1% reset preferences. Among 336 participants who initially excluded at least one category (36%), 38% reset preferences. Participants who reset preferences added 0.9 categories, on average; and their mean satisfaction on 0 to 10 scales increased from 4.7 to 7.2 ( p < .001). Only 2% reduced the number of categories they wanted disclosed. Findings demonstrate the benefits of providing examples of preference options and the tendency of participants to want results disclosed. Findings also suggest that preference-setting models that do not provide specific examples of results could underestimate participants' desires for information.
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Preferences for the return of individual results from research on pediatric biobank samples
Christensen, Kurt D.; Savage, Sarah K.; Huntington, Noelle L.; Weitzman, Elissa R.; Ziniel, Sonja I.; Bacon, Phoebe L.; Cacioppo, Cara N.; Green, Robert C.; Holm, Ingrid A.
2016-01-01
Discussions about disclosing individual genetic research results include calls to consider participants’ preferences. In this study, parents of Boston Children’s Hospital patients set preferences for disclosure based on disease preventability and severity, and could exclude mental health, developmental, childhood degenerative, and adult-onset disorders. Participants reviewed hypothetical reports and reset preferences, if desired. Among 661 participants who initially wanted all results (64%), 1% reset preferences. Among 336 participants who initially excluded at least one category (36%), 38% reset preferences. Participants who reset preferences added 0.9 categories, on average; and their mean satisfaction on 0–10 scales increased from 4.7 to 7.2 (p<0.001). Only 2% reduced the number of categories they wanted disclosed. Findings demonstrate the benefits of providing examples of preference options and the tendency of participants to want results disclosed. Findings also suggest that preference-setting models that do not provide specific examples of results could underestimate participants’ desires for information. PMID:28421887
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Effects of space environment on composites: An analytical study of critical experimental parameters
NASA Technical Reports Server (NTRS)
Gupta, A.; Carroll, W. F.; Moacanin, J.
1979-01-01
A generalized methodology currently employed at JPL, was used to develop an analytical model for effects of high-energy electrons and interactions between electron and ultraviolet effects. Chemical kinetic concepts were applied in defining quantifiable parameters; the need for determining short-lived transient species and their concentration was demonstrated. The results demonstrates a systematic and cost-effective means of addressing the issues and show qualitative and quantitative, applicable relationships between space radiation and simulation parameters. An equally important result is identification of critical initial experiments necessary to further clarify the relationships. Topics discussed include facility and test design; rastered vs. diffuse continuous e-beam; valid acceleration level; simultaneous vs. sequential exposure to different types of radiation; and interruption of test continuity.
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Heat Melt Compactor Development Progress
NASA Technical Reports Server (NTRS)
Lee, Jeffrey M.; Fisher, John W.; Pace, Gregory
2017-01-01
The status of the Heat Melt Compactor (HMC) development project is reported. HMC Generation 2 (Gen 2) has been assembled and initial testing has begun. A baseline mission use case for trash volume reduction, water recovery, trash sterilization, and the venting of effluent gases and water vapor to space has been conceptualized. A test campaign to reduce technical risks is underway. This risk reduction testing examines the many varied operating scenarios and conditions needed for processing trash during a space mission. The test results along with performance characterization of HMC Gen 2 will be used to prescribe requirements and specifications for a future ISS flight Technology Demonstration. We report on the current status, technical risks, and test results in the context of an ISS vent-to-space Technology Demonstration.
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Mechanics of wafer bonding: Effect of clamping
NASA Astrophysics Data System (ADS)
Turner, K. T.; Thouless, M. D.; Spearing, S. M.
2004-01-01
A mechanics-based model is developed to examine the effects of clamping during wafer bonding processes. The model provides closed-form expressions that relate the initial geometry and elastic properties of the wafers to the final shape of the bonded pair and the strain energy release rate at the interface for two different clamping configurations. The results demonstrate that the curvature of bonded pairs may be controlled through the use of specific clamping arrangements during the bonding process. Furthermore, it is demonstrated that the strain energy release rate depends on the clamping configuration and that using applied loads usually leads to an undesirable increase in the strain energy release rate. The results are discussed in detail and implications for process development and bonding tool design are highlighted.
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Nature and the river: a natural resources report of the Chicago and Calumet waterways.
Barbara J Moore; John D. Rogner; Drew Ullberg
1998-01-01
In 1992, the National Park Service initiated a project to galvanize local interest in the conservation and use of the Chicago Waterway System. The purpose of this project was to promote local stewardship of the waterway system through the integration of economic development, recreation, and environmental conservation. As a result, the ChicagoRivers Demonstration...
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NCI RNA Biology 2017 symposium recap | Center for Cancer Research
The recent discovery of new classes of RNAs and the demonstration that alterations in RNA metabolism underlie numerous human cancers have resulted in enormous interest among CCR investigators in RNA biology. In order to share the latest research in this exciting field, the CCR Initiative in RNA Biology held its second international symposium April 23-24, 2017, in Natcher
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United States-European Commission Urban Freight Twinning Initiative: Compendium of Project Summaries
DOT National Transportation Integrated Search
2017-09-01
This compendium is comprised of 33 brief summaries of urban freight initiatives that include research projects, plans, pilot demonstrations, and other efforts. These initiatives were presented at a roundtable discussion that was part of the 2017 Annu...
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Results of Ponseti Brasil Program: Multicentric Study in 1621 Feet: Preliminary Results.
Nogueira, Monica P; Queiroz, Ana C D B F; Melanda, Alessandro G; Tedesco, Ana P; Brandão, Antonio L G; Beling, Claudio; Violante, Francisco H; Brandão, Gilberto F; Ferreira, Laura F A; Brambila, Leandro S; Leite, Leopoldina M; Zabeu, Jose L; Kim, Jung H; Fernandes, Kalyana E; Arima, Marcia A S; Aguilar, Maria D P Q; Farias Filho, Orlando C D; Oliveira Filho, Oscar B D A; Pinho, Solange D S; Moulin, Paulo; Volpi, Reinaldo; Fox, Mark; Greenwald, Miles F; Lyle, Brandon; Morcuende, Jose A
The Ponseti method has been shown to be the most effective treatment for congenital clubfoot. The current challenge is to establish sustainable national clubfoot treatment programs that utilize the Ponseti method and integrate it within a nation's governmental health system. The Brazilian Ponseti Program (Programa Ponseti Brasil) has increased awareness of the utility of the Ponseti method and has trained >500 Brazilian orthopaedic surgeons in it. A group of 18 of those surgeons had been able to reproduce the Ponseti clubfoot treatment, and compiled their initial results through structured spreadsheet. The study compiled 1040 patients for a total of 1621 feet. The average follow-up time was 2.3 years with an average correction time of approximately 3 months. Patients required an average of 6.40 casts to achieve correction. This study demonstrates that good initial correction rates are reproducible after training; from 1040 patients only 1.4% required a posteromedial release. Level IV.
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DAT isn’t all that: cocaine reward and reinforcement requires Toll Like Receptor 4 signaling
Northcutt, A.L.; Hutchinson, M.R.; Wang, X.; Baratta, M.V.; Hiranita, T.; Cochran, T.A.; Pomrenze, M.B.; Galer, E.L.; Kopajtic, T.A.; Li, C.M.; Amat, J.; Larson, G.; Cooper, D.C.; Huang, Y.; O’Neill, C.E.; Yin, H.; Zahniser, N.R.; Katz, J.L.; Rice, K.C.; Maier, S.F.; Bachtell, R.K.; Watkins, L.R.
2014-01-01
The initial reinforcing properties of drugs of abuse, such as cocaine, are largely attributed to their ability to activate the mesolimbic dopamine system. Resulting increases in extracellular dopamine in the nucleus accumbens (NAc) are traditionally thought to result from cocaine’s ability to block dopamine transporters (DATs). Here we demonstrate that cocaine also interacts with the immunosurveillance receptor complex, Toll-Like Receptor 4 (TLR4), on microglial cells to initiate central innate immune signaling. Disruption of cocaine signaling at TLR4 suppresses cocaine-induced extracellular dopamine in the NAc, as well as cocaine conditioned place preference and cocaine self-administration. These results provide a novel understanding of the neurobiological mechanisms underlying cocaine reward/reinforcement that includes a critical role for central immune signaling, and offer a new target for medication development for cocaine abuse treatment. PMID:25644383
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Dynamics of anisotropic particles under waves
NASA Astrophysics Data System (ADS)
Dibenedetto, Michelle; Ouellette, Nicholas; Koseff, Jeffrey
2017-11-01
We present results on anisotropic particles in wavy flows in order to gain insight into the transport and mixing of microplastic particles in the near-shore environment. From theory and numerical simulations, we find that the rate of alignment of the particles is not constant and depends strongly on their initial orientation; thus, variations in initial particle orientation result in dispersion of anisotropic-particle plumes. We find that this dispersion is a function of the particle's eccentricity and the ratio of the settling and wave time scales. Experiments in which non-spherical particles of various shapes are released under surface gravity waves were also performed. Our main goal is to explore the effects of particle shape under various wave scenarios. We vary the aspect ratio of the particle in our experiments while holding other variables constant. Our results demonstrate that particle shape can be important when predicting transport.
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Hydrogen Fuel Cell Electric Vehicle Learning Demonstration | Hydrogen and
Fuel Cells | NREL Fuel Cell Electric Vehicle Learning Demonstration Hydrogen Fuel Cell Electric Vehicle Learning Demonstration Initiated in 2004, DOE's Controlled Hydrogen Fleet and Infrastructure Demonstration and Validation Project-later dubbed the Fuel Cell Electric Vehicle (FCEV) Learning Demonstration
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Al-Gharabli, Samer; Engeßer, Patrick; Gera, Diana; Klein, Sandra; Oppenländer, Thomas
2016-02-01
Excilamps are mercury-free gas-discharge sources of non-coherent VUV or UV radiation with high radiant power and a long lifetime. The most efficient excilamp that is currently available on the market is a VUV xenon excilamp system (Xe2(*)-excimer lamp, λ(max) = 172 nm) with a stated radiant efficiency η of 40% at an electrical input power P(el) of 20 W, 50 W or 100 W. In this paper, the use of this highly efficient Xe2(*)-excilamp (P(el) = 20 W) for water treatment is demonstrated using a recirculating laboratory photoreactor system with negative radiation geometry. The efficiency in the 172 nm initiated bleaching of aqueous solutions of Rhodamine B is compared to that initiated by a common low-pressure mercury (LP-Hg) lamp (185 nm, TNN 15/32). The dependence of the pseudo zero order rate constant k´ of decolorization of RhB on the flow rate and on the initial concentration of RhB was investigated. Both lamps exhibited dependences of k´ on the initial concentration of RhB, which represents a typical saturation kinetical behavior. The saturation kinetics was very prominent in the case of the Xe2(*)-excilamp. Also, the Xe2(*)-excilamp treatment exhibited a significant influence on the flow rate of the RhB aqueous solution, which was not the case during the LP-Hg lamp initiated bleaching of RhB. The results of this paper demonstrate that Xe2(*)-excilamps can be used for VUV-initiated water purification. However, to reach the maximum efficacy of the Xe2(*)-excilamp for photo-initiated water purification further engineering optimization of the photoreactor concept is necessary. Copyright © 2015 Elsevier Ltd. All rights reserved.
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Lim, Hyang-Tag; Hong, Kang-Hee; Kim, Yoon-Ho
2015-10-21
Quantum coherence and entanglement, which are essential resources for quantum information, are often degraded and lost due to decoherence. Here, we report a proof-of-principle experimental demonstration of high fidelity entanglement distribution over decoherence channels via qubit transduction. By unitarily switching the initial qubit encoding to another, which is insensitive to particular forms of decoherence, we have demonstrated that it is possible to avoid the effect of decoherence completely. In particular, we demonstrate high-fidelity distribution of photonic polarization entanglement over quantum channels with two types of decoherence, amplitude damping and polarization-mode dispersion, via qubit transduction between polarization qubits and dual-rail qubits. These results represent a significant breakthrough in quantum communication over decoherence channels as the protocol is input-state independent, requires no ancillary photons and symmetries, and has near-unity success probability.
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Lim, Hyang-Tag; Hong, Kang-Hee; Kim, Yoon-Ho
2015-01-01
Quantum coherence and entanglement, which are essential resources for quantum information, are often degraded and lost due to decoherence. Here, we report a proof-of-principle experimental demonstration of high fidelity entanglement distribution over decoherence channels via qubit transduction. By unitarily switching the initial qubit encoding to another, which is insensitive to particular forms of decoherence, we have demonstrated that it is possible to avoid the effect of decoherence completely. In particular, we demonstrate high-fidelity distribution of photonic polarization entanglement over quantum channels with two types of decoherence, amplitude damping and polarization-mode dispersion, via qubit transduction between polarization qubits and dual-rail qubits. These results represent a significant breakthrough in quantum communication over decoherence channels as the protocol is input-state independent, requires no ancillary photons and symmetries, and has near-unity success probability. PMID:26487083
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Classical Demonstration of Polarization.
ERIC Educational Resources Information Center
Bauman, Robert P.; Moore, Dennis R.
1980-01-01
Presents a classical demonstration of polarization for high school students. The initial state of this model, which demonstrates the important concepts of the optical and quantum problems, was developed during the 1973 summer program on lecture demonstration at the U.S. Naval Academy. (HM)
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The Expert System Programme of the European Space Agency
NASA Astrophysics Data System (ADS)
Lafay, J. F.; Allard, F.
1992-08-01
ESA's Expert System Demonstration (ESD) program is discussed in terms of its goals, structure, three-phase approach, and initial results. ESD is intended to demonstrate the benefits of AI and knowledge-based systems for in-orbit infrastructures by developing a strategic technology to contribute to ESA missions. Three phases were defined for: (1) program definition and review of existing work; (2) demonstration of applications prototypes; and (3) the development of operational systems from successful prototypes. Applications of 16 proposed expert-system candidates are grouped into payload-engineering and crew/operations categories. The candidates are to be evaluated in terms of their potential contribution to strategic goals such as improving scientific return and automating operator functions to eliminate human error.
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Computational aspects of helicopter trim analysis and damping levels from Floquet theory
NASA Technical Reports Server (NTRS)
Gaonkar, Gopal H.; Achar, N. S.
1992-01-01
Helicopter trim settings of periodic initial state and control inputs are investigated for convergence of Newton iteration in computing the settings sequentially and in parallel. The trim analysis uses a shooting method and a weak version of two temporal finite element methods with displacement formulation and with mixed formulation of displacements and momenta. These three methods broadly represent two main approaches of trim analysis: adaptation of initial-value and finite element boundary-value codes to periodic boundary conditions, particularly for unstable and marginally stable systems. In each method, both the sequential and in-parallel schemes are used and the resulting nonlinear algebraic equations are solved by damped Newton iteration with an optimally selected damping parameter. The impact of damped Newton iteration, including earlier-observed divergence problems in trim analysis, is demonstrated by the maximum condition number of the Jacobian matrices of the iterative scheme and by virtual elimination of divergence. The advantages of the in-parallel scheme over the conventional sequential scheme are also demonstrated.
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Laser-Induced Breakdown Spectroscopy (LIBS) in a Novel Molten Salt Aerosol System.
Williams, Ammon N; Phongikaroon, Supathorn
2017-04-01
In the pyrochemical separation of used nuclear fuel (UNF), fission product, rare earth, and actinide chlorides accumulate in the molten salt electrolyte over time. Measuring this salt composition in near real-time is advantageous for operational efficiency, material accountability, and nuclear safeguards. Laser-induced breakdown spectroscopy (LIBS) has been proposed and demonstrated as a potential analytical approach for molten LiCl-KCl salts. However, all the studies conducted to date have used a static surface approach which can lead to issues with splashing, low repeatability, and poor sample homogeneity. In this initial study, a novel molten salt aerosol approach has been developed and explored to measure the composition of the salt via LIBS. The functionality of the system has been demonstrated as well as a basic optimization of the laser energy and nebulizer gas pressure used. Initial results have shown that this molten salt aerosol-LIBS system has a great potential as an analytical technique for measuring the molten salt electrolyte used in this UNF reprocessing technology.
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Xin, Hong-Wu; Hari, Danielle M.; Mullinax, John E.; Ambe, Chenwi M.; Koizumi, Tomotake; Ray, Satyajit; Anderson, Andrew J.; Wiegand, Gordon W.; Garfield, Susan H.; Thorgeirsson, Snorri S.; Avital, Itzhak
2012-01-01
Label-retaining cells (LRCs) have been proposed to represent adult tissue stem cells. LRCs are hypothesized to result from either slow cycling or asymmetric cell division (ACD). However, the stem cell nature and whether LRC undergo ACD remain controversial. Here, we demonstrate label-retaining cancer cells (LRCCs) in several gastrointestinal (GI) cancers including fresh surgical specimens. Using a novel method for isolation of live LRCC, we demonstrate that a subpopulation of LRCC is actively dividing and exhibits stem cells and pluripotency gene expression profiles. Using real-time confocal microscopic cinematography, we show live LRCC undergoing asymmetric nonrandom chromosomal cosegregation LRC division. Importantly, LRCCs have greater tumor-initiating capacity than non-LRCCs. Based on our data and that cancers develop in tissues that harbor normal-LRC, we propose that LRCC might represent a novel population of GI stem-like cancer cells. LRCC may provide novel mechanistic insights into the biology of cancer and regenerative medicine and present novel targets for cancer treatment. PMID:22331764
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Sewage outfall plume dispersion observations with an autonomous underwater vehicle.
Ramos, P; Cunha, S R; Neves, M V; Pereira, F L; Quintaneiro, I
2005-01-01
This work represents one of the first successful applications of Autonomous Underwater Vehicles (AUVs) for interdisciplinary coastal research. A monitoring mission to study the shape and estimate the initial dilution of the S. Jacinto sewage outfall plume using an AUV was performed on July 2002. An efficient sampling strategy enabling greater improvements in spatial and temporal range of detection demonstrated that the sewage effluent plume can be clearly traced using naturally occurring tracers in the wastewater. The outfall plume was found at the surface highly influenced by the weak stratification and low currents. Dilution varying with distance downstream was estimated from the plume rise over the outfall diffuser until a nearly constant value of 130:1, 60 m from the diffuser, indicating the near field end. Our results demonstrate that AUVs can provide high-quality measurements of physical properties of effluent plumes in a very effective manner and valuable considerations about the initial mixing processes under real oceanic conditions can be further investigated.
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Novel high-frequency, high-power, pulsed oscillator based on a transmission line transformer.
Burdt, R; Curry, R D
2007-07-01
Recent analysis and experiments have demonstrated the potential for transmission line transformers to be employed as compact, high-frequency, high-power, pulsed oscillators with variable rise time, high output impedance, and high operating efficiency. A prototype system was fabricated and tested that generates a damped sinusoidal wave form at a center frequency of 4 MHz into a 200 Omega load, with operating efficiency above 90% and peak power on the order of 10 MW. The initial rise time of the pulse is variable and two experiments were conducted to demonstrate initial rise times of 12 and 3 ns, corresponding to a spectral content from 4-30 and from 4-100 MHz, respectively. A SPICE model has been developed to accurately predict the circuit behavior and scaling laws have been identified to allow for circuit design at higher frequencies and higher peak power. The applications, circuit analysis, test stand, experimental results, circuit modeling, and design of future systems are all discussed.
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Suppression of autophagy impedes glioblastoma development and induces senescence.
Gammoh, Noor; Fraser, Jane; Puente, Cindy; Syred, Heather M; Kang, Helen; Ozawa, Tatsuya; Lam, Du; Acosta, Juan Carlos; Finch, Andrew J; Holland, Eric; Jiang, Xuejun
2016-09-01
The function of macroautophagy/autophagy during tumor initiation or in established tumors can be highly distinct and context-dependent. To investigate the role of autophagy in gliomagenesis, we utilized a KRAS-driven glioblastoma mouse model in which autophagy is specifically disrupted via RNAi against Atg7, Atg13 or Ulk1. Inhibition of autophagy strongly reduced glioblastoma development, demonstrating its critical role in promoting tumor formation. Further supporting this finding is the observation that tumors originating from Atg7-shRNA injections escaped the knockdown effect and thereby still underwent functional autophagy. In vitro, autophagy inhibition suppressed the capacity of KRAS-expressing glial cells to form oncogenic colonies or to survive low serum conditions. Molecular analyses revealed that autophagy-inhibited glial cells were unable to maintain active growth signaling under growth-restrictive conditions and were prone to undergo senescence. Overall, these results demonstrate that autophagy is crucial for glioma initiation and growth, and is a promising therapeutic target for glioblastoma treatment.
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Instrumentation for electrochemical performance characterization of neural electrodes
NASA Astrophysics Data System (ADS)
Marsh, Michael P.; Kruchowski, James N.; Hara, Seth A.; McIntosh, Malcom B.; Forsman, Renae M.; Reed, Terry L.; Kimble, Christopher; Lee, Kendall H.; Bennet, Kevin E.; Tomshine, Jonathan R.
2017-08-01
In an effort to determine the chronic stability, sensitivity, and thus the potential viability of various neurochemical recording electrode designs and compositions, we have developed a custom device called the Voltammetry Instrument for Neurochemical Applications (VINA). Here, we describe the design of the VINA and initial testing of its functionality for prototype neurochemical sensing electrodes. The VINA consists of multiple electrode fixtures, a flowing electrolyte bath, associated reservoirs, peristaltic pump, voltage waveform generator, data acquisition hardware, and system software written in National Instrument's LabVIEW. The operation of VINA was demonstrated on a set of boron-doped diamond neurochemical recording electrodes, which were subjected to an applied waveform for a period of eighteen days. Each electrode's cyclic voltammograms (CVs) were recorded, and sensitivity calibration to dopamine (DA) was performed. Results showed an initial decline with subsequent stabilization in the CV current measured during the voltammetric sweep, corresponding closely with changes in electrode sensitivity to DA. The VINA has demonstrated itself as a useful tool for the characterization of electrode stability and chronic electrochemical performance.
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NASA Astrophysics Data System (ADS)
Jang, Inae; Lee, Sun Young; Hwangbo, Song; Kang, Dukjin; Lee, Hookeun; Kim, Hugh I.; Moon, Bongjin; Oh, Han Bin
2017-01-01
The present study demonstrates that one-step peptide backbone fragmentations can be achieved using the TEMPO [2-(2,2,6,6-tetramethyl piperidine-1-oxyl)]-assisted free radical-initiated peptide sequencing (FRIPS) mass spectrometry in a hybrid quadrupole time-of-flight (Q-TOF) mass spectrometer and a Q-Exactive Orbitrap instrument in positive ion mode, in contrast to two-step peptide fragmentation in an ion-trap mass spectrometer (reference Anal. Chem. 85, 7044-7051 (30)). In the hybrid Q-TOF and Q-Exactive instruments, higher collisional energies can be applied to the target peptides, compared with the low collisional energies applied by the ion-trap instrument. The higher energy deposition and the additional multiple collisions in the collision cell in both instruments appear to result in one-step peptide backbone dissociations in positive ion mode. This new finding clearly demonstrates that the TEMPO-assisted FRIPS approach is a very useful tool in peptide mass spectrometry research.
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Phillips, M L; David, A S
1997-11-01
Left hemi-face (LHF) perceptual bias of chimeric faces in normal right-handers is well-documented. We investigated mechanisms underlying this by measuring visual scan paths in right-handed normal controls (n = 9) and schizophrenics (n = 8) for simple, full-face photographs and schematic, happy-sad chimeric faces over 5 s. Normals viewed the left side/ LHF first, more so than the right of all stimuli. Schizophrenics viewed the LHF first more than the right of stimuli for which there was a LHF choice of predominant affect. Neither group demonstrated an overall LHF perceptual bias for the chimeric stimuli. Readjustment of the initial LHF bias in controls was probably a result of increased attention to stimulus detail with scanning, whereas the schizophrenics demonstrated difficulty in redirection of the initial focus of attention. The study highlights the role of visual scan paths as a marker of normal and abnormal attentional processes. Copyright 1997 Academic Press.
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Yan, Li; Ye, Jie; Zhang, Panyue; Xu, Dong; Wu, Yan; Liu, Jianbo; Zhang, Haibo; Fang, Wei; Wang, Bei; Zeng, Guangming
2018-07-01
High sulfur content in excess sludge impacts the production of biomethane during anaerobic digestion, meanwhile leads to hydrogen sulfide (H 2 S) formation in biogas. Effect of initial sludge pH on H 2 S formation during batch mesophilic anaerobic digestion of slaughterhouse wastewater sludge was studied in this paper. The results demonstrated that when the initial sludge pH increased from 6.5 to 8.0, the biogas production increased by 10.1%, the methane production increased by 64.1%, while the H 2 S content in biogas decreased by 44.7%. The higher initial sludge pH inhibited the competition of sulfate-reducing bacteria with methane-producing bacteria, and thus benefitted the growth of methanogens. Positive correlation was found between the relative abundance of Desulfomicrobium and H 2 S production, as well as the relative abundance of Methanosarcina and methane production. More sulfates and organic sulfur were transferred to solid and liquid rather than H 2 S formation at a high initial pH. Copyright © 2018 Elsevier Ltd. All rights reserved.
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AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet.
Jurėnas, Dukas; Chatterjee, Sneha; Konijnenberg, Albert; Sobott, Frank; Droogmans, Louis; Garcia-Pino, Abel; Van Melderen, Laurence
2017-06-01
Toxin-antitoxin (TA) loci are prevalent in bacterial genomes. They are suggested to play a central role in dormancy and persister states. Under normal growth conditions, TA toxins are neutralized by their cognate antitoxins, and under stress conditions, toxins are freed and inhibit essential cellular processes using a variety of mechanisms. Here we characterize ataR-ataT, a novel TA system, from enterohemorrhagic Escherichia coli. We show that the toxin AtaT is a GNAT family enzyme that transfers an acetyl group from acetyl coenzyme A to the amine group of the methionyl aminoacyl moiety of initiator tRNA. AtaT specifically modifies Met-tRNA fMet , but no other aminoacyl-tRNAs, including the elongator Met-tRNA Met . We demonstrate that once acetylated, AcMet-tRNA fMet fails to interact with initiation factor-2 (IF2), resulting in disruption of the translation initiation complex. This work reveals a new mechanism of translation inhibition and confirms Met-tRNA fMet as a prime target to efficiently block cell growth.
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Burton, Rachel A; Lallemand, Nicole M; Peters, Rebecca A; Zuckerman, Stephen
2018-02-05
Through the Multi-Payer Advanced Primary Care Practice (MAPCP) Demonstration, Medicare, Medicaid, and private payers offered supplemental payments to 849 primary care practices that became patient-centered medical homes (PCMHs) in eight states; practices also received technical assistance and data reports. Average Medicare payments were capped at $10 per beneficiary per month in each state. Since there was variation in the eight participating states' demonstration designs, experiences, and outcomes, we conducted a qualitative multi-case analysis to identify the key factors that differentiated states that were estimated to have generated net savings for Medicare from states that did not. States' MAPCP Demonstration initiatives were comprehensively profiled in case studies based on secondary document review, three rounds of annual interviews with state staff, payers, practices, and other stakeholders, and other data sources. Case study findings were summarized in a case-ordered predictor-outcome matrix, which identified the presence or absence of key demonstration design features and experiences and arrayed states based on the amount of net savings or losses they generated for Medicare. We then used this matrix to identify initiative features that were present in at least three of the four states that generated net savings and absent from at least three of the four states that did not generate savings. A majority of the states that generated net savings: required practices to be recognized PCMHs to enter the demonstration, did not allow late entrants into the demonstration, used a consistent demonstration payment model across participating payers, and offered practices opportunities to earn performance bonuses. Practices in states that generated net savings also tended to report receiving the demonstration payments and bonuses they expected to receive, without any issues. Designers of future PCMH initiatives may increase their likelihood of generating net savings by incorporating the demonstration features we identified.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Ge, Yuqing; Zhou, Fengbiao; Chen, Hong
2010-07-09
Sox2, a master transcription factor, contributes to the generation of induced pluripotent stem cells and plays significant roles in sustaining the self-renewal of neural stem cells and glioma-initiating cells. Understanding the functional differences of Sox2 between glioma-initiating cells and normal neural stem cells would contribute to therapeutic approach for treatment of brain tumors. Here, we first demonstrated that Sox2 could contribute to the self-renewal and proliferation of glioma-initiating cells. The following experiments showed that Sox2 was activated at translational level in a subset of human glioma-initiating cells compared with the normal neural stem cells. Further investigation revealed there was amore » positive correlation between Sox2 and eukaryotic initiation factor 4E (eIF4E) in glioma tissues. Down-regulation of eIF4E decreased Sox2 protein level without altering its mRNA level in glioma-initiating cells, indicating that Sox2 was activated by eIF4E at translational level. Furthermore, eIF4E was presumed to regulate the expression of Sox2 by its 5' untranslated region (5' UTR) sequence. Our results suggest that the eIF4E-Sox2 axis is a novel mechanism of unregulated self-renewal of glioma-initiating cells, providing a potential therapeutic target for glioma.« less
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Li, Yafan; Wheeler, Deric L; Ananthaswamy, Honnavara N; Verma, Ajit K; Oberley, Terry D
2007-12-01
Our previous studies showed that protein kinase Cepsilon (PKCepsilon) verexpression in mouse skin resulted in metastatic squamous cell carcinoma (SCC) elicited by single 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion in the absence of preceding papilloma formation as is typically observed in wild type mice. The present study demonstrates that double-DMBA initiation modulates tumor incidence, multiplicity, and latency period in both wild type and PKCepsilon overexpression transgenic (PKCepsilon-Tg) mice. After 17 weeks (wks) of tumor promotion, a reduction in papilloma multiplicity was observed in double- versus single-DMBA initiated wild type mice. Papilloma multiplicity was inversely correlated with cell death indices of interfollicular keratinocytes, indicating decreased papilloma formation was caused by increased cell death and suggesting the origin of papillomas is in interfollicular epidermis. Double-initiated PKCepsilon-Tg mice had accelerated carcinoma formation and cancer incidence in comparison to single-initiated PKCepsilon-Tg mice. Morphologic analysis of mouse skin following double initiation and tumor promotion showed a similar if not identical series of events to those previously observed following single initiation and tumor promotion: putative preneoplastic cells were observed arising from hyperplastic hair follicles (HFs) with subsequent cancer cell infiltration into the dermis. Single-initiated PKCepsilon-Tg mice exhibited increased mitosis in epidermal cells of HFs during tumor promotion.
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Early Stage of Oxidation on Titanium Surface by Reactive Molecular Dynamics Simulation
Yang, Liang; Wang, C. Z.; Lin, Shiwei; ...
2018-01-01
Understanding of metal oxidation is very critical to corrosion control, catalysis synthesis, and advanced materials engineering. Metal oxidation is a very complex phenomenon, with many different processes which are coupled and involved from the onset of reaction. In this work, the initial stage of oxidation on titanium surface was investigated in atomic scale by molecular dynamics (MD) simulations using a reactive force field (ReaxFF). We show that oxygen transport is the dominant process during the initial oxidation. Our simulation also demonstrate that a compressive stress was generated in the oxide layer which blocked the oxygen transport perpendicular to the Titaniummore » (0001) surface and further prevented oxidation in the deeper layers. As a result, the mechanism of initial oxidation observed in this work can be also applicable to other self-limiting oxidation.« less
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Neutral Silicon-Vacancy Center in Diamond: Spin Polarization and Lifetimes
NASA Astrophysics Data System (ADS)
Green, B. L.; Mottishaw, S.; Breeze, B. G.; Edmonds, A. M.; D'Haenens-Johansson, U. F. S.; Doherty, M. W.; Williams, S. D.; Twitchen, D. J.; Newton, M. E.
2017-09-01
We demonstrate optical spin polarization of the neutrally charged silicon-vacancy defect in diamond (SiV0 ), an S =1 defect which emits with a zero-phonon line at 946 nm. The spin polarization is found to be most efficient under resonant excitation, but nonzero at below-resonant energies. We measure an ensemble spin coherence time T2>100 μ s at low-temperature, and a spin relaxation limit of T1>25 s . Optical spin-state initialization around 946 nm allows independent initialization of SiV0 and NV- within the same optically addressed volume, and SiV0 emits within the telecoms down-conversion band to 1550 nm: when combined with its high Debye-Waller factor, our initial results suggest that SiV0 is a promising candidate for a long-range quantum communication technology.
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DOT National Transportation Integrated Search
2000-10-01
The Phoenix, Arizona Metropolitan Model Deployment was one of four cities included in the Metropolitan Model Deployment Initiative (MMDI). The initiative was set forth in 1996 to serve as model deployments of ITS infrastructure and integration. One o...
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5 CFR 470.205 - Initiation of research programs.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Initiation of research programs. 470.205... PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.205 Initiation of research programs. OPM will announce opportunities for research...
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5 CFR 470.205 - Initiation of research programs.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Initiation of research programs. 470.205... PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.205 Initiation of research programs. OPM will announce opportunities for research...
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40 CFR 63.11562 - What are my initial compliance requirements?
Code of Federal Regulations, 2011 CFR
2011-07-01
... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Area Sources: Asphalt Processing and Asphalt Roofing Manufacturing Standards and Compliance Requirements § 63.11562 What are my initial compliance requirements? (a) For asphalt processing operations, you must: (1) Demonstrate initial...
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40 CFR 63.11562 - What are my initial compliance requirements?
Code of Federal Regulations, 2014 CFR
2014-07-01
... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Area Sources: Asphalt Processing and Asphalt Roofing Manufacturing Standards and Compliance Requirements § 63.11562 What are my initial compliance requirements? (a) For asphalt processing operations, you must: (1) Demonstrate initial...
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40 CFR 63.11562 - What are my initial compliance requirements?
Code of Federal Regulations, 2012 CFR
2012-07-01
... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Area Sources: Asphalt Processing and Asphalt Roofing Manufacturing Standards and Compliance Requirements § 63.11562 What are my initial compliance requirements? (a) For asphalt processing operations, you must: (1) Demonstrate initial...
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40 CFR 63.11562 - What are my initial compliance requirements?
Code of Federal Regulations, 2013 CFR
2013-07-01
... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Area Sources: Asphalt Processing and Asphalt Roofing Manufacturing Standards and Compliance Requirements § 63.11562 What are my initial compliance requirements? (a) For asphalt processing operations, you must: (1) Demonstrate initial...
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40 CFR 63.11562 - What are my initial compliance requirements?
Code of Federal Regulations, 2010 CFR
2010-07-01
... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Area Sources: Asphalt Processing and Asphalt Roofing Manufacturing Standards and Compliance Requirements § 63.11562 What are my initial compliance requirements? (a) For asphalt processing operations, you must: (1) Demonstrate initial...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... conduct performance tests upon initial startup or no later than 180 calendar days after the compliance... initial startup or no later than 30 calendar days after the compliance date that is specified for your...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... conduct performance tests upon initial startup or no later than 180 calendar days after the compliance... initial startup or no later than 30 calendar days after the compliance date that is specified for your...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-05
... Information Collection: Transformation Initiative Family Self-Sufficiency Demonstration Small Grants AGENCY... information: Title of Proposal: Notice of Funding Availability for the Transformation Initiative Family Self..., think tanks, consortia, Institutions of higher education accredited by a national or regional...
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Connecting remote systems for demonstration of automation technologies
NASA Technical Reports Server (NTRS)
Brown, R. M.; Yee, R.
1988-01-01
An initial estimate of the communications requirements of the Systems Autonomy Demonstration Project (SADP) development and demonstration environments is presented. A proposed network paradigm is developed, and options for network topologies are explored.
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Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 13 2011-07-01 2011-07-01 false What test methods and other procedures must I use to demonstrate initial compliance with the TDS or constituent limits for quench water? 63.7325 Section 63.7325 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR...
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NASA Astrophysics Data System (ADS)
Burritt, Rosemary; Francois, Elizabeth; Windler, Gary; Chavez, David
2017-06-01
Diaminoazoxyfurazan (DAAF) has many of the safety characteristics of an insensitive high explosive (IHE): it is extremely insensitive to impact and friction and is comparable to triaminotrinitrobezene (TATB) in this way. Conversely, it demonstrates many performance characteristics of a Conventional High Explosive (CHE). DAAF has a small failure diameter of about 1.25 mm and can be sensitive to shock under the right conditions. Large particle sized DAAF will not initiate in a typical exploding foil initiator (EFI) configuration but smaller particle sizes will. Large particle sized DAAF, of 40 μm, was crash precipitated and ball milled into six distinct samples and pressed into pellets with a density of 1.60 g/cc (91% TMD). To investigate the effect of particle size and surface area on the direct initiation on DAAF multiple threshold tests were preformed on each sample of DAAF in different EFI configurations, which varied in flyer thickness and/or bridge size. Comparative tests were performed examining threshold voltage and correlated to Photon Doppler Velocimetry (PDV) results. The samples with larger particle sizes and surface area required more energy to initiate while the smaller particle sizes required less energy and could be initiated with smaller diameter flyers.
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Metrical expectations from preceding prosody influence perception of lexical stress
Brown, Meredith; Salverda, Anne Pier; Dilley, Laura C.; Tanenhaus, Michael K.
2015-01-01
Two visual-world experiments tested the hypothesis that expectations based on preceding prosody influence the perception of suprasegmental cues to lexical stress. The results demonstrate that listeners’ consideration of competing alternatives with different stress patterns (e.g., ‘jury/gi’raffe) can be influenced by the fundamental frequency and syllable timing patterns across material preceding a target word. When preceding stressed syllables distal to the target word shared pitch and timing characteristics with the first syllable of the target word, pictures of alternatives with primary lexical stress on the first syllable (e.g., jury) initially attracted more looks than alternatives with unstressed initial syllables (e.g., giraffe). This effect was modulated when preceding unstressed syllables had pitch and timing characteristics similar to the initial syllable of the target word, with more looks to alternatives with unstressed initial syllables (e.g., giraffe) than to those with stressed initial syllables (e.g., jury). These findings suggest that expectations about the acoustic realization of upcoming speech include information about metrical organization and lexical stress, and that these expectations constrain the initial interpretation of suprasegmental stress cues. These distal prosody effects implicate on-line probabilistic inferences about the sources of acoustic-phonetic variation during spoken-word recognition. PMID:25621583
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2013-01-01
Background Prior studies demonstrated that hesitation-prone persons with Parkinson’s disease (PDs) acutely improve step initiation using a novel self-triggered stimulus that enhances lateral weight shift prior to step onset. PDs showed reduced anticipatory postural adjustment (APA) durations, earlier step onsets, and faster 1st step speed immediately following stimulus exposure. Objective This study investigated the effects of long-term stimulus exposure. Methods Two groups of hesitation-prone subjects with Parkinson’s disease (PD) participated in a 6-week step-initiation training program involving one of two stimulus conditions: 1) Drop. The stance-side support surface was lowered quickly (1.5 cm); 2) Vibration. A short vibration (100 ms) was applied beneath the stance-side support surface. Stimuli were self-triggered by a 5% reduction in vertical force under the stance foot during the APA. Testing was at baseline, immediately post-training, and 6 weeks post-training. Measurements included timing and magnitude of ground reaction forces, and step speed and length. Results Both groups improved their APA force modulation after training. Contrary to previous results, neither group showed reduced APA durations or earlier step onset times. The vibration group showed 55% increase in step speed and a 39% increase in step length which were retained 6 weeks post-training. The drop group showed no stepping-performance improvements. Conclusions The acute sensitivity to the quickness-enhancing effects of stimulus exposure demonstrated in previous studies was supplanted by improved force modulation following prolonged stimulus exposure. The results suggest a potential approach to reduce the severity of start hesitation in PDs, but further study is needed to understand the relationship between short- and long-term effects of stimulus exposure. PMID:23363975
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Hartford Gerontological Nursing Leaders: From Funding Initiative to National Organization.
Van Cleave, Janet H; Szanton, Sarah L; Shillam, Casey; Rose, Karen; Rao, Aditi D; Perez, Adriana; O'Connor, Melissa; Walker, Rachel; Buron, Bill; Boltz, Marie; Bellot, Jennifer; Batchelor-Murphy, Melissa
2016-01-01
In 2000, the John A. Hartford Foundation established the Building Academic Geriatric Nursing Capacity Program initiative, acknowledging nursing's key role in the care of the growing population of older adults. This program has supported 249 nurse scientists with pre- and postdoctoral awards. As a result of the program's success, several Building Academic Geriatric Nursing Capacity Program awardees formed an alumni organization to continue to advance the quality care of older adults. This group of Building Academic Geriatric Nursing Capacity Program awardees joined others receiving support from the John A. Hartford Foundation nursing initiatives to grow a formal organization, the Hartford Gerontological Nursing Leaders (HGNL). The purpose of this article is to present the development, accomplishments, and challenges of the HGNL, informing other professional nursing organizations that are experiencing similar accomplishments and challenges. This article also demonstrates the power of a funding initiative to grow an organization dedicated to impact gerontological health and health care through research, practice, education, and policy. Copyright © 2016 Elsevier Inc. All rights reserved.
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Photoactive high explosives: linear and nonlinear photochemistry of petrin tetrazine chloride.
Greenfield, Margo T; McGrane, Shawn D; Bolme, Cindy A; Bjorgaard, Josiah A; Nelson, Tammie R; Tretiak, Sergei; Scharff, R Jason
2015-05-21
Pentaerythritol tetranitrate (PETN), a high explosive, initiates with traditional shock and thermal mechanisms. In this study, the tetrazine-substituted derivative of PETN, pentaerythritol trinitrate chlorotetrazine (PetrinTzCl), is being investigated for a photochemical initiation mechanism that could allow control over the chemistry contributing to decomposition leading to initiation. PetrinTzCl exhibits a photochemical quantum yield (QYPC) at 532 nm not evident with PETN. Using static spectroscopic methods, we observe energy absorption on the tetrazine (Tz) ring that results in photodissociation yielding N2, Cl-CN, and Petrin-CN as the major photoproducts. The QYPC was enhanced with increasing irradiation intensity. Experiment and theoretical calculations imply this excitation mechanism follows sequential photon absorption. Dynamic simulations demonstrate that the relaxation mechanism leading to the observed photochemistry in PetrinTzCl is due to vibrational excitation during internal conversion. PetrinTzCl's single photon stability and intensity dependence suggest this material could be stable in ambient lighting, yet possible to initiate with short-pulsed lasers.
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Ludwin, Brian M; Meeks, Suzanne
2018-05-03
This study examined the validity of a psychological model for understanding nursing home providers' treatment choices when managing challenging dementia-related behaviors. Ninety-nine nurses from 26 long-term care facilities responded to a case study with their intentions to initiate an antipsychotic or psychosocial intervention and completed self-report measures of their attitudes, descriptive norms, self-efficacy, and outcome expectancies. The multi-level modeling results demonstrated that nurses with more positive outcome expectancies for the effect of an antipsychotic on resident behavior, and those with more positive attitudes towards antipsychotics, had greater intentions to initiate an antipsychotic. Intentions to initiate a psychosocial intervention were greater when nurses perceived a lower prevalence of antipsychotics and in facilities with nurses who collectively had higher self-efficacy to implement such interventions. The findings offer partial support for the proposed model and possible intervention targets to improve psychosocial intervention use and antipsychotic prescribing. Published by Elsevier Inc.
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PhoneSat: Ground Testing of a Phone-Based Prototype Bus
NASA Technical Reports Server (NTRS)
Felix, Carmen; Howard, Benjamin; Reyes, Matthew; Snarskiy, Fedor; Hickman, Ryan; Boshuizen, Christopher; Marshall, William
2010-01-01
Most of the key capabilities that are requisite of a satellite bus are housed in today's smart phones. PhoneSat refers to an initiative to build a ground-based prototype vehicle that could all the basic functionality of a satellite, including attitude control, using a smart Phone as its central hardware. All components used were also low cost Commercial off the Shelf (COTS). In summer 2009, an initial prototype was created using the LEGO Mindstorm toolkit demonstrating simple attitude control. Here we report on a follow up initiative to design, build and test a vehicle based on the Google s smart phone Nexus One. The report includes results from initial thermal-vacuum chamber tests and low altitude sub-orbital rocket flights which show that, at least for short durations, the Nexus One phone is able to withstand key aspects of the space environment without failure. We compare the sensor data from the Phone's accelerometers and magnetometers with that of an external microelectronic inertial measurement unit.
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Sustained culture and surgical outcome improvement.
Babic, Bruna; Volpe, Anita Ayrandjian; Merola, Stephen; Mauer, Elizabeth; Cozacov, Yaniv; Ko, Clifford Y; Michelassi, Fabrizio; Saldinger, Pierre
2018-02-16
A focus on the culture of safety and patient outcomes continues to grow in importance. Several initiatives targeted at individual deficits have been described but few institutions have shown the effect of a global change in culture on patient outcomes. Patient care perception was assessed using Safety Attitudes Questionnaire (SAQ) by Pascal Metrics ® . A change in culture was initiated, followed by implementation of initiatives targeting communication and patient safety. ACS-NSQIP data was analyzed to assess outcomes during the period of improved culture. Our institution had poor outcomes as measured by ACS-NSQIP data and several deficiencies in our culture score. Both statistically improved after initiative implementation. A difference in mean culture score across time (p < 0.001 = .031) was seen from 2013 to 2015, while NSQIP odds ratios falling in the 'exemplary' category increased. Our results demonstrate an improvement in both culture and outcomes from 2013 to 2015, suggesting a correlation between culture and surgical outcomes. Copyright © 2018 Elsevier Inc. All rights reserved.
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Optimization of High-Dimensional Functions through Hypercube Evaluation
Abiyev, Rahib H.; Tunay, Mustafa
2015-01-01
A novel learning algorithm for solving global numerical optimization problems is proposed. The proposed learning algorithm is intense stochastic search method which is based on evaluation and optimization of a hypercube and is called the hypercube optimization (HO) algorithm. The HO algorithm comprises the initialization and evaluation process, displacement-shrink process, and searching space process. The initialization and evaluation process initializes initial solution and evaluates the solutions in given hypercube. The displacement-shrink process determines displacement and evaluates objective functions using new points, and the search area process determines next hypercube using certain rules and evaluates the new solutions. The algorithms for these processes have been designed and presented in the paper. The designed HO algorithm is tested on specific benchmark functions. The simulations of HO algorithm have been performed for optimization of functions of 1000-, 5000-, or even 10000 dimensions. The comparative simulation results with other approaches demonstrate that the proposed algorithm is a potential candidate for optimization of both low and high dimensional functions. PMID:26339237
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Parafoveal preview during reading: Effects of sentence position
White, Sarah J.; Warren, Tessa; Reichle, Erik D.
2011-01-01
Two experiments examined parafoveal preview for words located in the middle of sentences and at sentence boundaries. Parafoveal processing was shown to occur for words at sentence-initial, mid-sentence, and sentence-final positions. Both Experiments 1 and 2 showed reduced effects of preview on regressions out for sentence-initial words. In addition, Experiment 2 showed reduced preview effects on first-pass reading times for sentence-initial words. These effects of sentence position on preview could result from reduced parafoveal processing for sentence-initial words, or other processes specific to word reading at sentence boundaries. In addition to the effects of preview, the experiments also demonstrate variability in the effects of sentence wrap-up on different reading measures, indicating that the presence and time course of wrap-up effects may be modulated by text-specific factors. We also report simulations of Experiment 2 using version 10 of E-Z Reader (Reichle, Warren, & McConnell, 2009), designed to explore the possible mechanisms underlying parafoveal preview at sentence boundaries. PMID:21500948
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Green, Douglas H.; Wurzinger, Brian
2012-01-01
Purpose/Background: Both forefoot strike shod (FFS) and barefoot (BF) running styles result in different mechanics when compared to rearfoot strike (RFS) shod running. Additionally, running mechanics of FFS and BF running are similar to one another. Comparing the mechanical changes occurring in each of these patterns is necessary to understand potential benefits and risks of these running styles. The authors hypothesized that FFS and BF conditions would result in increased sagittal plane joint angles at initial contact and that FFS and BF conditions would demonstrate a shift in sagittal plane joint power from the knee to the ankle when compared to the RFS condition. Finally, total lower extremity power absorption will be least in BF and greatest in the RFS shod condition. Methods: The study included 10 male and 10 female RFS runners who completed 3‐dimensional running analysis in 3 conditions: shod with RFS, shod with FFS, and BF. Variables were the angles of plantarflexion, knee flexion, and hip flexion at initial contact and peak sagittal plane joint power at the hip, knee, and ankle during stance phase. Results: Running with a FFS pattern and BF resulted in significantly greater plantarflexion and significantly less negative knee power (absorption) when compared to shod RFS condition. FFS condition runners landed in the most plantarflexion and demonstrated the most peak ankle power absorption and lowest knee power absorption between the 3 conditions. BF and FFS conditions demonstrated decreased total lower extremity power absorption compared to the shod RFS condition but did not differ from one another. Conclusions: BF and FFS running result in reduced total lower extremity power, hip power and knee power and a shift of power absorption from the knee to the ankle. Clinical Relevance: Alterations associated with BF running patterns are present in a FFS pattern when wearing shoes. Additionally, both patterns result in increased demand at the foot and ankle as compared to the knee. PMID:23091785
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Servello, David F; Fallis, Drew W; Alvetro, Lisa
2015-01-01
To assess skeletal and dental changes in patients successfully treated with the Forsus appliance based on cervical vertebral maturation status. Forty-seven Class II patients, successfully treated with the Forsus appliance, were divided into peak and postpeak growth groups determined immediately prior to Forsus placement. The mean (SD) ages of the peak and postpeak groups were 13.4 (1.0) and 14.1 (1.3) years, respectively. Superimpositions of initial, Forsus placement, Forsus removal, and final cephalometric radiographs were completed, allowing the measurement of changes during three treatment phases. There were no significant differences between groups during treatment phase 1 (alignment/leveling), with both groups demonstrating a worsening of the Class II molar relationship. However, during treatment phase 2 (Class II correction), patients within the peak group demonstrated significantly higher mean apical base, mandibular and molar changes, and an increased rate of change compared with those in the postpeak group. No significant differences were observed during treatment phase 3 (detail/finishing). Following an initial worsening of the Class II molar relationship as a result of straight-wire appliance effects, Forsus appliance treatment initiated during cervical vertebral maturation status (CS) 3-4 elicits more effective and efficient correction of Class II molar relationships than when initiated during CS 5-6. Data support that these effects are due mainly to maxillary skeletal and dentoalveolar restraint during a period of more rapid mandibular growth.
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Analysis and Hindcast Experiments of the 2009 Sudden Stratospheric Warming in WACCMX+DART
NASA Astrophysics Data System (ADS)
Pedatella, N. M.; Liu, H.-L.; Marsh, D. R.; Raeder, K.; Anderson, J. L.; Chau, J. L.; Goncharenko, L. P.; Siddiqui, T. A.
2018-04-01
The ability to perform data assimilation in the Whole Atmosphere Community Climate Model eXtended version (WACCMX) is implemented using the Data Assimilation Research Testbed (DART) ensemble adjustment Kalman filter. Results are presented demonstrating that WACCMX+DART analysis fields reproduce the middle and upper atmosphere variability during the 2009 major sudden stratospheric warming (SSW) event. Compared to specified dynamics WACCMX, which constrains the meteorology by nudging toward an external reanalysis, the large-scale dynamical variability of the stratosphere, mesosphere, and lower thermosphere is improved in WACCMX+DART. This leads to WACCMX+DART better representing the downward transport of chemical species from the mesosphere into the stratosphere following the SSW. WACCMX+DART also reproduces most aspects of the observed variability in ionosphere total electron content and equatorial vertical plasma drift during the SSW. Hindcast experiments initialized on 5, 10, 15, 20, and 25 January are used to assess the middle and upper atmosphere predictability in WACCMX+DART. A SSW, along with the associated middle and upper atmosphere variability, is initially predicted in the hindcast initialized on 15 January, which is ˜10 days prior to the warming. However, it is not until the hindcast initialized on 20 January that a major SSW is forecast to occur. The hindcast experiments reveal that dominant features of the total electron content can be forecasted ˜10-20 days in advance. This demonstrates that whole atmosphere models that properly account for variability in lower atmosphere forcing can potentially extend the ionosphere-thermosphere forecast range.
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Bebell, Lisa M; Siedner, Mark J; Musinguzi, Nicholas; Boum, Yap; Bwana, Bosco M; Muyindike, Winnie; Hunt, Peter W; Martin, Jeffrey N; Bangsberg, David R
2017-07-01
Recent ecological data demonstrate improving outcomes for HIV-infected people in sub-Saharan Africa. Recently, Uganda has experienced a resurgence in HIV incidence and prevalence, but trends in HIV-related deaths have not been well described. Data were collected through the Uganda AIDS Rural Treatment Outcomes (UARTO) Study, an observational longitudinal cohort of Ugandan adults initiating antiretroviral therapy (ART) between 2005 and 2013. We calculated cumulative incidence of death within one year of ART initiation, and fit Poisson models with robust variance estimators to estimate the effect enrollment period on one-year risk of death and loss to follow-up. Of 760 persons in UARTO who started ART, 30 deaths occurred within one year of ART initiation (cumulative incidence 3.9%, 95% confidence interval [CI] 2.7-5.6%). Risk of death was highest for those starting ART in 2005 (13.0%, 95% CI 6.0-24.0%), decreased in 2006-2007 to 4% (95% CI 2.0-6.0%), and did not change thereafter ( P = 0.61). These results were robust to adjustment for age, sex, CD4 cell count, viral load, asset wealth, baseline depression, and body mass index. Here, we demonstrate that one-year cumulative incidence of death was high just after free ART rollout, decreased the following year, and remained low thereafter. Once established, ART programs in President's Emergency Fund for AIDS Relief-supported countries can maintain high quality care.
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Brantuo, Mary N A; Cristofalo, Elizabeth; Meheš, Mira M; Ameh, Juliana; Brako, Nana Okai; Boahene, Frederick; Adjei, Stella B; Opoku, Ernest; Banda, Harriet; Wang, Yu T; Forgor, Abdulai A; Punguire, Damien; Brightson, Kennedy; Sottie, Cynthia; Owusu-Agyei, Seth; Williams, John E; Sulemana, Abubakari; Oduro, Abraham R; Gyampong, Margaret; Sarpong, Doris; Andrews, Edith; Gyansa-Lutterodt, Martha; Hodgson, Abraham; Bannerman, Cynthia; Abdullah, Fizan
2014-04-01
To evaluate the impact of a district hospital intervention focused on enhancing healthcare provider capacity to address leading causes of neonatal death: birth asphyxia, infection and prematurity. The neonatal quality improvement initiative was launched at two intervention referral district hospitals in Ghana. Local Health and Demographic Surveillance Systems were enlisted to enhance recording of neonatal and infant deaths in the community and at the facility. After baseline site assessments, a team of local paediatric experts conducted three clinical trainings on-site at each intervention hospital. Assessments were conducted to evaluate participant knowledge before and after participation in training modules. Monthly mentorship visits provided additional training to support the adoption of essential early neonatal care practices. In the first year of implementation, the initiative provided focused clinical training to 278 participants. A comparison of pre- and post-training test results demonstrates significant improvement in provider knowledge (73% vs. 89% correct, P < 0.001), with even greater improvement among trainees receiving recurrent refresher training (86% vs. 94% correct, P < 0.001). Participant feedback following training revealed enthusiasm about the programme and improved confidence. Locally led initiatives that invest directly in healthcare provider education and health systems strengthening represent a promising avenue for reducing neonatal morbidity and mortality. The NQI initiative demonstrates the positive impact of a district hospital intervention that combines on-site training, mentorship and enhanced demographic surveillance. © 2014 John Wiley & Sons Ltd.
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Jipp, Meike
2016-12-01
This study explored whether working memory and sustained attention influence cognitive lock-up, which is a delay in the response to consecutive automation failures. Previous research has demonstrated that the information that automation provides about failures and the time pressure that is associated with a task influence cognitive lock-up. Previous research has also demonstrated considerable variability in cognitive lock-up between participants. This is why individual differences might influence cognitive lock-up. The present study tested whether working memory-including flexibility in executive functioning-and sustained attention might be crucial in this regard. Eighty-five participants were asked to monitor automated aircraft functions. The experimental manipulation consisted of whether or not an initial automation failure was followed by a consecutive failure. Reaction times to the failures were recorded. Participants' working-memory and sustained-attention abilities were assessed with standardized tests. As expected, participants' reactions to consecutive failures were slower than their reactions to initial failures. In addition, working-memory and sustained-attention abilities enhanced the speed with which participants reacted to failures, more so with regard to consecutive than to initial failures. The findings highlight that operators with better working memory and sustained attention have small advantages when initial failures occur, but their advantages increase across consecutive failures. The results stress the need to consider personnel selection strategies to mitigate cognitive lock-up in general and training procedures to enhance the performance of low ability operators. © 2016, Human Factors and Ergonomics Society.
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A moving baseline for evaluation of advanced coal extraction systems
NASA Technical Reports Server (NTRS)
Bickerton, C. R.; Westerfield, M. D.
1981-01-01
Results from the initial effort to establish baseline economic performance comparators for a program whose intent is to define, develop, and demonstrate advanced systems suitable for coal resource extraction beyond the year 2000 are reported. Systems used were selected from contemporary coal mining technology and from conservation conjectures of year 2000 technology. The analysis was also based on a seam thickness of 6 ft. Therefore, the results are specific to the study systems and the selected seam extended to other seam thicknesses.
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Preclinical Justification of pbi-shRNA EWS/FLI1 Lipoplex (LPX) Treatment for Ewing's Sarcoma.
Rao, Donald D; Jay, Christopher; Wang, Zhaohui; Luo, Xiuquan; Kumar, Padmasini; Eysenbach, Hilary; Ghisoli, Maurizio; Senzer, Neil; Nemunaitis, John
2016-08-01
The EWS/FLI1 fusion gene is well characterized as a driver of Ewing's sarcoma. Bi-shRNA EWS/FLI1 is a functional plasmid DNA construct that transcribes both siRNA and miRNA-like effectors each of which targets the identical type 1 translocation junction region of the EWS/FLI1 transcribed mRNA sequence. Previous preclinical and clinical studies confirm the safety of this RNA interference platform technology and consistently demonstrate designated mRNA and protein target knockdown at greater than 90% efficiency. We initiated development of pbi-shRNA EWS/FLI1 lipoplex (LPX) for the treatment of type 1 Ewing's sarcoma. Clinical-grade plasmid was manufactured and both sequence and activity verified. Target protein and RNA knockdown of 85-92% was demonstrated in vitro in type 1 human Ewing's sarcoma tumor cell lines with the optimal bi-shRNA EWS/FLI1 plasmid. This functional plasmid was placed in a clinically tested, liposomal (LP) delivery vehicle followed by in vivo verification of activity. Type 1 Ewing's sarcoma xenograft modeling confirmed dose related safety and tumor response to pbi-shRNA EWS/FLI1 LPX. Toxicology studies in mini-pigs with doses comparable to the demonstrated in vivo efficacy dose resulted in transient fever, occasional limited hypertension at low- and high-dose assessment and transient liver enzyme elevation at high dose. These results provide the justification to initiate clinical testing.
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Preclinical Justification of pbi-shRNA EWS/FLI1 Lipoplex (LPX) Treatment for Ewing's Sarcoma
Rao, Donald D.; Jay, Christopher; Wang, Zhaohui; Luo, Xiuquan; Kumar, Padmasini; Eysenbach, Hilary; Ghisoli, Maurizio; Senzer, Neil; Nemunaitis, John
2016-01-01
The EWS/FLI1 fusion gene is well characterized as a driver of Ewing's sarcoma. Bi-shRNA EWS/FLI1 is a functional plasmid DNA construct that transcribes both siRNA and miRNA-like effectors each of which targets the identical type 1 translocation junction region of the EWS/FLI1 transcribed mRNA sequence. Previous preclinical and clinical studies confirm the safety of this RNA interference platform technology and consistently demonstrate designated mRNA and protein target knockdown at greater than 90% efficiency. We initiated development of pbi-shRNA EWS/FLI1 lipoplex (LPX) for the treatment of type 1 Ewing's sarcoma. Clinical-grade plasmid was manufactured and both sequence and activity verified. Target protein and RNA knockdown of 85–92% was demonstrated in vitro in type 1 human Ewing's sarcoma tumor cell lines with the optimal bi-shRNA EWS/FLI1 plasmid. This functional plasmid was placed in a clinically tested, liposomal (LP) delivery vehicle followed by in vivo verification of activity. Type 1 Ewing's sarcoma xenograft modeling confirmed dose related safety and tumor response to pbi-shRNA EWS/FLI1 LPX. Toxicology studies in mini-pigs with doses comparable to the demonstrated in vivo efficacy dose resulted in transient fever, occasional limited hypertension at low- and high-dose assessment and transient liver enzyme elevation at high dose. These results provide the justification to initiate clinical testing. PMID:27166877
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Physical initialization using SSM/I rain rates
NASA Technical Reports Server (NTRS)
Krishnamurti, T. N.; Bedi, H. S.; Ingles, Kevin
1993-01-01
Following our recent study on physical initialization for tropical prediction using rain rates based on outgoing long-wave radiation, the present study demonstrates a major improvement from the use of microwave radiance-based rain rates. A rain rate algorithm is used on the data from a special sensor microwave instrument (SSM/I). The initialization, as before, uses a reverse surface similarity theory, a reverse cumulus parameterization algorithm, and a bisection method to minimize the difference between satellite-based and the model-based outgoing long-wave radiation. These are invoked within a preforecast Newtonian relaxation phase of the initialization. These tests are carried out with a high-resolution global spectral model. The impact of the initialization on forecast is tested for a complex triple typhoon scenario over the Western Pacific Ocean during September 1987. A major impact from the inclusion of the SSM/I is demonstrated. Also addressed are the spin-up issues related to the typhoon structure and the improved water budget from the physical initialization.
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Foust, Amanda; Popovic, Marko; Zecevic, Dejan; McCormick, David A.
2010-01-01
Purkinje neurons are the output cells of the cerebellar cortex and generate spikes in two distinct modes, known as simple and complex spikes. Revealing the point of origin of these action potentials, and how they conduct into local axon collaterals, is important for understanding local and distal neuronal processing and communication. By utilizing a recent improvement in voltage sensitive dye imaging technique that provided exceptional spatial and temporal resolution, we were able to resolve the region of spike initiation as well as follow spike propagation into axon collaterals for each action potential initiated on single trials. All fast action potentials, for both simple and complex spikes, whether occurring spontaneously or in response to a somatic current pulse or synaptic input, initiated in the axon initial segment. At discharge frequencies of less than approximately 250 Hz, spikes propagated faithfully through the axon and axon collaterals, in a saltatory manner. Propagation failures were only observed for very high frequencies or for the spikelets associated with complex spikes. These results demonstrate that the axon initial segment is a critical decision point in Purkinje cell processing and that the properties of axon branch points are adjusted to maintain faithful transmission. PMID:20484631
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Effect of initiator concentration to low-density polyethylene production in a tubular reactor
NASA Astrophysics Data System (ADS)
Azmi, A.; Aziz, N.
2016-11-01
Low-density polyethylene (LDPE) is one of the most widely used polymers in the world, which is produced in high-capacity tubular and autoclave reactors. As the LDPE industry turn into more competitive and its market profit margins become tighter, manufacturers have to develop solutions to debottleneck the reactor output while abiding to the stringent product specification. A single polyolefin plant producing ten to forty grades of LDPE with various melt flow index (MFI), therefore understanding the reaction mechanism, the operating conditions as well as the dynamic behavior of tubular reactor is essential before any improvement can take place. In the present work, a steady state mathematical model representing a tubular reactor for the production of LDPE is simulated using MATLAB R2015a®. The model developed is a function of feed inlet, reactor jacket, single initiator injector and outlet stream. Analysis on the effect of initiator concentration (CI) shows sudden declining trend of initiator's concentration which indicates that all of the initiators are exhausted after polymerization reaction and no further reaction occur from this point onwards. Furthermore, the results demonstrate that the concentration of initiator gives significant impact on reactor temperature's profile and monomer conversion rate, since higher initiator concentration promotes greater polymerization rate, and therefore leads to higher monomer conversion throughput.
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Directed current in the Holstein system.
Hennig, D; Burbanks, A D; Osbaldestin, A H
2011-03-01
We propose a mechanism to rectify charge transport in the semiclassical Holstein model. It is shown that localized initial conditions associated with a polaron solution, in conjunction with static electron on-site potential not having inversion symmetry, constitute minimal prerequisites for the emergence of a directed current in the underlying periodic lattice system. In particular, we demonstrate that for unbiased spatially localized initial conditions (constituted by kicked static polaron states), violation of parity prevents the existence of pairs of counterpropagating trajectories, thus allowing for a directed current despite the time reversibility of the equations of motion. Nevertheless, propagating polaron solutions associated with sets of unbiased localized initial conditions which eventually leave the region of localized initial conditions do not exhibit time reversibility. Since the initial conditions belonging to the corresponding counterpropagating, current-compensating polaron solutions are not contained in the set, this gives rise to the emergence of a current. Occurrence of long-range coherent charge transport is demonstrated.
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Initial Multidisciplinary Design and Analysis Framework
NASA Technical Reports Server (NTRS)
Ozoroski, L. P.; Geiselhart, K. A.; Padula, S. L.; Li, W.; Olson, E. D.; Campbell, R. L.; Shields, E. W.; Berton, J. J.; Gray, J. S.; Jones, S. M.;
2010-01-01
Within the Supersonics (SUP) Project of the Fundamental Aeronautics Program (FAP), an initial multidisciplinary design & analysis framework has been developed. A set of low- and intermediate-fidelity discipline design and analysis codes were integrated within a multidisciplinary design and analysis framework and demonstrated on two challenging test cases. The first test case demonstrates an initial capability to design for low boom and performance. The second test case demonstrates rapid assessment of a well-characterized design. The current system has been shown to greatly increase the design and analysis speed and capability, and many future areas for development were identified. This work has established a state-of-the-art capability for immediate use by supersonic concept designers and systems analysts at NASA, while also providing a strong base to build upon for future releases as more multifidelity capabilities are developed and integrated.
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Nuclear thermal propulsion transportation systems for lunar/Mars exploration
NASA Technical Reports Server (NTRS)
Clark, John S.; Borowski, Stanley K.; Mcilwain, Melvin C.; Pellaccio, Dennis G.
1992-01-01
Nuclear thermal propulsion technology development is underway at NASA and DoE for Space Exploration Initiative (SEI) missions to Mars, with initial near-earth flights to validate flight readiness. Several reactor concepts are being considered for these missions, and important selection criteria will be evaluated before final selection of a system. These criteria include: safety and reliability, technical risk, cost, and performance, in that order. Of the concepts evaluated to date, the Nuclear Engine for Rocket Vehicle Applications (NERVA) derivative (NDR) is the only concept that has demonstrated full power, life, and performance in actual reactor tests. Other concepts will require significant design work and must demonstrate proof-of-concept. Technical risk, and hence, development cost should therefore be lowest for the concept, and the NDR concept is currently being considered for the initial SEI missions. As lighter weight, higher performance systems are developed and validated, including appropriate safety and astronaut-rating requirements, they will be considered to support future SEI application. A space transportation system using a modular nuclear thermal rocket (NTR) system for lunar and Mars missions is expected to result in significant life cycle cost savings. Finally, several key issues remain for NTR's, including public acceptance and operational issues. Nonetheless, NTR's are believed to be the 'next generation' of space propulsion systems - the key to space exploration.
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NASA Astrophysics Data System (ADS)
Sato, Ayuko; Iwasaki, Akiko
2004-11-01
Pattern recognition by Toll-like receptors (TLRs) is known to be important for the induction of dendritic cell (DC) maturation. DCs, in turn, are critically important in the initiation of T cell responses. However, most viruses do not infect DCs. This recognition system poses a biological problem in ensuring that most viral infections be detected by pattern recognition receptors. Furthermore, it is unknown what, if any, is the contribution of TLRs expressed by cells that are infected by a virus, versus TLRs expressed by DCs, in the initiation of antiviral adaptive immunity. Here we address these issues using a physiologically relevant model of mucosal infection with herpes simplex virus type 2. We demonstrate that innate immune recognition of viral infection occurs in two distinct stages, one at the level of the infected epithelial cells and the other at the level of the noninfected DCs. Importantly, both TLR-mediated recognition events are required for the induction of effector T cells. Our results demonstrate that virally infected tissues instruct DCs to initiate the appropriate class of effector T cell responses and reveal the critical importance of the stromal cells in detecting infectious agents through their own pattern recognition receptors. mucosal immunity | pattern recognition | viral infection
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Mallett, Kimberly A; Ray, Anne E; Turrisi, Rob; Belden, Calum; Bachrach, Rachel L; Larimer, Mary E
2010-07-01
The current study tested age of onset as a moderator of intervention efficacy on drinking and consequence outcomes among a high-risk population of college students (i.e., former high school athletes). Students were randomized to one of four conditions: assessment only control, combined parent-based intervention (PBI) and brief motivational intervention (BMI), PBI alone, and BMI alone. Participants (n = 1,275) completed web-administered measures at baseline (summer before starting college) and 10-month follow-up. Overall, the combined intervention demonstrated the strongest and most consistent reductions across all outcomes, particularly with the youngest initiators. Participants who initiated drinking at the youngest ages had significantly lower peak drinking, typical weekly drinking, and reported consequences at follow-up when they received the combined intervention when compared to the control group. The BMI and PBI groups, when examined independently, demonstrated significant effects across outcomes but were inconsistent across the different age groups. Results suggest the combination of a PBI and a peer-delivered BMI is an appropriate and efficacious way to reduce drinking and related consequences among individuals who initiated drinking earlier in adolescence and are at an increased risk of experiencing alcohol problems.
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Torous, John; Nebeker, Camille
2017-02-08
Research studies that leverage emerging technologies, such as passive sensing devices and mobile apps, have demonstrated encouraging potential with respect to favorably influencing the human condition. As a result, the nascent fields of mHealth and digital medicine have gained traction over the past decade as demonstrated in the United States by increased federal funding for research that cuts across a broad spectrum of health conditions. The existence of mHealth and digital medicine also introduced new ethical and regulatory challenges that both institutional review boards (IRBs) and researchers are struggling to navigate. In response, the Connected and Open Research Ethics (CORE) initiative was launched. The CORE initiative has employed a participatory research approach, whereby researchers and IRB affiliates are involved in identifying the priorities and functionality of a shared resource. The overarching goal of CORE is to develop dynamic and relevant ethical practices to guide mHealth and digital medicine research. In this Viewpoint paper, we describe the CORE initiative and call for readers to join the CORE Network and contribute to the bigger conversation on ethics in the digital age. ©John Torous, Camille Nebeker. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 08.02.2017.
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Chan, Olivia; Hall, Håkan; Elford, Alisha R.; Yen, Patty; Calzascia, Thomas; Spencer, David M.; Ohashi, Pamela S.
2017-01-01
Although the role of T cells in autoimmunity has been explored for many years, the mechanisms leading to the initial priming of an autoimmune T cell response remain enigmatic. The ‘hit and run’ model suggests that self-antigens released upon cell death can provide the initial signal for a self-sustaining autoimmune response. Using a novel transgenic mouse model where we could induce the release of self-antigens via caspase-dependent apoptosis. We tracked the fate of CD8+ T cells specific for the self-antigen. Our studies demonstrated that antigens released from apoptotic cells were cross-presented by CD11c+ cells in the draining lymph node. This cross-presentation led to proliferation of self-antigen specific T cells, followed by a transient ability to produce IFN-γ, but did not lead to the development of autoimmune diabetes. Using this model we examined the consequences on T cell immunity when apoptosis was combined with dendritic cell maturation signals, an autoimmune susceptible genetic background, and the deletion of Tregs. The results of our study demonstrate that autoimmune diabetes cannot be initiated by the presentation of antigens released from apoptotic cells in vivo even in the presence of factors known to promote autoimmunity. PMID:28257518
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Harris, Keith M; Aboujaoude, Elias
2016-08-01
Online relationships are increasingly central to many people's lives. As a result, there is a growing need to scientifically examine their psychosocial implications. This study developed and tested the Online Relationship Initiation Scale (ORIS) through classical and item response theory analyses to address this need. An anonymous online survey included 713 adults, aged 18-71 years. The ORIS was tested on psychometric properties and examined for associations with gender and several standardized psychosocial measures. Results demonstrated unidimensionality of nine items, strong factor loadings, and high internal consistency (α = 0.90, ωt = 0.94). All items captured significant information on the latent trait and none showed differential item functioning by sex, age group, or ethnicity. General linear modeling confirmed hypotheses that men were more likely than women to initiate online relationships. Online relationship initiation was not strongly associated with perceived social support, but was positively related to financial distress, and willingness to engage in infidelity or unprotected sex. The ORIS was negatively associated with age and satisfaction with life and showed modest interactions with ethnicity and hours online. This study provided empirical evidence for an interpersonal relationship initiation construct. The ORIS was shown to be a psychometrically sound instrument for evaluating online interpersonal behaviors and their associations with psychosocial and demographic factors. Such psychometrically sound instruments can be useful in exploring online interpersonal behaviors and their significance.
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NASA Astrophysics Data System (ADS)
Bosman, Peter A. N.; Alderliesten, Tanja
2016-03-01
We recently demonstrated the strong potential of using dual-dynamic transformation models when tackling deformable image registration problems involving large anatomical differences. Dual-dynamic transformation models employ two moving grids instead of the common single moving grid for the target image (and single fixed grid for the source image). We previously employed powerful optimization algorithms to make use of the additional flexibility offered by a dual-dynamic transformation model with good results, directly obtaining insight into the trade-off between important registration objectives as a result of taking a multi-objective approach to optimization. However, optimization has so far been initialized using two regular grids, which still leaves a great potential of dual-dynamic transformation models untapped: a-priori grid alignment with image structures/areas that are expected to deform more. This allows (far) less grid points to be used, compared to using a sufficiently refined regular grid, leading to (far) more efficient optimization, or, equivalently, more accurate results using the same number of grid points. We study the implications of exploiting this potential by experimenting with two new smart grid initialization procedures: one manual expert-based and one automated image-feature-based. We consider a CT test case with large differences in bladder volume with and without a multi-resolution scheme and find a substantial benefit of using smart grid initialization.
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Lower limb ice application alters ground reaction force during gait initiation
Muniz, Thiago B.; Moraes, Renato; Guirro, Rinaldo R. J.
2015-01-01
BACKGROUND: Cryotherapy is a widely used technique in physical therapy clinics and sports. However, the effects of cryotherapy on dynamic neuromuscular control are incompletely explained. OBJECTIVES: To evaluate the effects of cryotherapy applied to the calf, ankle and sole of the foot in healthy young adults on ground reaction forces during gait initiation. METHOD: This study evaluated the gait initiation forces, maximum propulsion, braking forces and impulses of 21 women volunteers through a force platform, which provided maximum and minimum ground reaction force values. To assess the effects of cooling, the task - gait initiation - was performed before ice application, immediately after and 30 minutes after removal of the ice pack. Ice was randomly applied on separate days to the calf, ankle and sole of the foot of the participants. RESULTS: It was demonstrated that ice application for 30 minutes to the sole of the foot and calf resulted in significant changes in the vertical force variables, which returned to their pre-application values 30 minutes after the removal of the ice pack. Ice application to the ankle only reduced propulsion impulse. CONCLUSIONS: These results suggest that although caution is necessary when performing activities that require good gait control, the application of ice to the ankle, sole of the foot or calf in 30-minute intervals may be safe even preceding such activities. PMID:25993625
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Goodrich, J. Marc; Lonigan, Christopher J.; Farver, JoAnn M.
2013-01-01
The purpose of this study was to evaluate the cross-language transfer of the emergent literacy skills of preschoolers who were Spanish-speaking language minority children in the context of an experimental intervention study. Ninety-four children were randomly assigned to either a control condition (High/Scope preschool curriculum) or to receive small-group pull-out instruction (Literacy Express Preschool Curriculum) in English or initially in Spanish and transitioning to English. We examined whether children's initial skills in one language moderated the impact of the intervention on those same skills in the other language at posttest. Results demonstrated that, for children in the English-only intervention condition, initial Spanish receptive vocabulary and elision skills moderated the impact of the intervention on English receptive vocabulary and elision skills at posttest, respectively. For children in the transitional intervention condition, initial English definitional vocabulary and elision skills moderated the impact of the intervention on Spanish definitional vocabulary and elision skills at posttest, respectively. Results for the vocabulary interactions, as well as the elision interaction for the English-only intervention group comparisons, supported the notion of transfer of specific linguistic information across languages. Results for elision interaction for the transitional intervention group comparisons supported language-independent transfer. Implications for the theory of cross-language transfer of emergent literacy skills are discussed. PMID:24019555
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Space Exploration Technologies Developed through Existing and New Research Partnerships Initiatives
NASA Technical Reports Server (NTRS)
Nall, Mark; Casas, Joseph
2004-01-01
The Space Partnership Development Program of NASA has been highly successful in leveraging commercial research investments to the strategic mission and applied research goals of the Agency through industry academic partnerships. This program is currently undergoing an outward-looking transformation towards Agency wide research and discovery goals that leverage partnership contributions to the strategic research needed to demonstrate enabling space exploration technologies encompassing both robotic spacecraft missions and human space flight. New Space Partnership Initiatives with incremental goals and milestones will allow a continuing series of accomplishments to be achieved throughout the duration of each initiative, permit the "lessons learned" and capabilities acquired from previous implementation steps to be incorporated into subsequent phases of the initiatives, and allow adjustments to be made to the implementation of the initiatives as new opportunities or challenges arise. An Agency technological risk reduction roadmap for any required technologies not currently available will identify the initiative focus areas for the development, demonstration and utilization of space resources supporting the production of power, air, and water, structures and shielding materials. This paper examines the successes to date, lessons learned, and programmatic outlook of enabling sustainable exploration and discovery through governmental, industrial, academic, and international partnerships. Previous government and industry technology development programs have demonstrated that a focused research program that appropriately shares the developmental risk can rapidly mature low Technology Readiness Level (TRL) technologies to the demonstration level. This cost effective and timely, reduced time to discovery, partnership approach to the development of needed technological capabilities addresses the dual use requirements by the investing partners. In addition, these partnerships help to ensure the attainment of complimenting human and robotic exploration goals for NASA while providing additional capabilities for sustainable scientific research benefiting life and security on Earth.