Science.gov

Sample records for injection control summary

  1. State and National Energy and Environmental Risk Analysis Systems for Underground Injection Control. Summary annual report, April 1993--April 1994

    SciTech Connect

    Smith, G.E.

    1994-04-01

    ICF Resources` project, entitled {open_quotes}State and National Energy and Environmental Risk Analysis Systems for Underground Injection Control{close_quotes} originally included two primary tasks (development of state and national systems respectively) and a technology transfer element. The state system was planned to assist states with data management related to underground injection control (UIC). However, during the current period, a change was received to the Statement of Work which discontinued work on this task. Prior to discontinuation, the concept for a protocol that would assess the relative risk of groundwater contamination due to UIC activities in various areas of a state was developed. A risk assessment protocol similar to that designed could be used to assist states in allocating scarce resources and potentially could form the analytical basis of a state variance program. The national energy and environmental risk analysis system (EERAS) is designed to enhance DOE`s analytical capabilities. This concept will be demonstrated using UIC data. The initial system design for EERAS has been completed but may be revised based on input from DOE and on the pending UIC regulatory changes. Data have been collected and organized and can be input once the file structure is finalized. The further development options for EERAS defined as part of this project will allow for the full development of the system beyond the current prototype phase, which will enhance DOE`s analytical capabilities for responding to regulatory initiatives and for evaluating the benefits of risk-based regulatory approaches.

  2. State and National Energy and Environmental Risk Analysis Systems for underground injection control. Summary annual report, April 1992--April 1993

    SciTech Connect

    Haas, M.R.

    1993-04-01

    ICF Resources` project, entitled {open_quotes}State and National Energy and Environmental Risk Analysis Systems for Underground Injection Control{close_quotes} includes two primary tasks (development of state and national systems respectively) and a technology transfer element. The state system was designed to assist states with data management related to underground injection control (UIC). However, during the current period, external changes (primarily pending regulatory changes at the federal level) have made the risk assessment protocol aspect of the state system of increased importance relative to data management. This protocol would assess the relative risk of groundwater contamination due to UIC activities in various areas of the state. The risk assessment system could be used to assist states in allocating scarce resources and potentially could form the analytical basis of a state variance program to respond to pending federal regulatory changes. Consequently, a substantial portion of the effort to date has been focused on this aspect of the project, The national energy and environmental risk analysis system (EERAS) is designed to enhance DOE`s analytical capabilities. This concept will be demonstrated using UIC data. The initial system design for EERAS has been completed but may be revised based on input from DOE and on the pending UIC regulatory changes. Data have been collected and organized and can be input once the file structure is finalized. The further development options for EERAS defined as part of this project will allow for the full development of the system beyond the current prototype phase which will enhance DOE`s analytical capabilities for responding to regulatory initiatives and for evaluating the benefits of risk-based regulatory approaches.

  3. Injection rate control cam

    SciTech Connect

    Perr, J.P.; Liang, E.; Yu, R.C.; Ghuman, A.S.

    1990-10-16

    This patent describes a cam for controlling the injection rate of fuel in a fuel injection system of an engine. The fuel injection system including a cyclically operating unit injector having a body, an injector plunger mounted for reciprocating movement in the injector body between an advanced position and a retracted portion to pump into the engine during each cycle a variable quantity of fuel up to a maximum quantity under rated engine conditions, and a drive train for converting rotational movement of the cam into reciprocating movement of the pumping plunger depending on the profile of the cam. The cam profile comprises at least a plunger retraction segment and a plunger advancement segment for controlling the velocity if injector plunger retraction and advancement, respectively, the plunger advancement segment including a pre-injection subsequent shaped to cause an initial quantity of fuel to be injected into the engine during each cycle at rated engine conditions while the pre-injection subsegment is in contact with the drive train, and an injection subsegment following the pre-injection subsegment.

  4. Underground Injection Control (UIC)

    EPA Pesticide Factsheets

    Provide information on: individual injection well classes; regulations specific to each well class; technical guidance; compliance assistance; federal, state, and tribal/territory roles and responsibilities.

  5. Injection-controlled laser resonator

    DOEpatents

    Chang, Jim J.

    1995-07-18

    A new injection-controlled laser resonator incorporates self-filtering and self-imaging characteristics with an efficient injection scheme. A low-divergence laser signal is injected into the resonator, which enables the injection signal to be converted to the desired resonator modes before the main laser pulse starts. This injection technique and resonator design enable the laser cavity to improve the quality of the injection signal through self-filtering before the main laser pulse starts. The self-imaging property of the present resonator reduces the cavity induced diffraction effects and, in turn, improves the laser beam quality.

  6. Injection-controlled laser resonator

    DOEpatents

    Chang, J.J.

    1995-07-18

    A new injection-controlled laser resonator incorporates self-filtering and self-imaging characteristics with an efficient injection scheme. A low-divergence laser signal is injected into the resonator, which enables the injection signal to be converted to the desired resonator modes before the main laser pulse starts. This injection technique and resonator design enable the laser cavity to improve the quality of the injection signal through self-filtering before the main laser pulse starts. The self-imaging property of the present resonator reduces the cavity induced diffraction effects and, in turn, improves the laser beam quality. 5 figs.

  7. Cryogenic thermal control technology summaries

    NASA Technical Reports Server (NTRS)

    Stark, J. A.; Leonhard, K. E.; Bennett, F. O., Jr.

    1974-01-01

    A summarization and categorization is presented of the pertinent literature associated with cryogenic thermal control technology having potential application to in-orbit fluid transfer systems and/or associated space storage. Initially, a literature search was conducted to obtain pertinent documents for review. Reports determined to be of primary significance were summarized in detail. Each summary, where applicable, consists of; (1) report identification, (2) objective(s) of the work, (3) description of pertinent work performed, (4)major results, and (5) comments of the reviewer (GD/C). Specific areas covered are; (1) multilayer insulation of storage tanks with and without vacuum jacketing, (2) other insulation such as foams, shadow shields, microspheres, honeycomb, vent cooling and composites, (3) vacuum jacketed and composite fluid lines, and (4) low conductive tank supports and insulation penetrations. Reports which were reviewed and not summarized, along with reasons for not summarizing, are also listed.

  8. 77 FR 52717 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... AGENCY Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection; Cornerstone Chemical Company, Waggaman, LA AGENCY... granted to Cornerstone for four Class I injection wells located at Waggaman, Louisiana. The company...

  9. 78 FR 23246 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... AGENCY Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection; BASF Corporation Freeport, Texas AGENCY: Environmental... granted to BASF Corporation for three Class I injection wells located at Freeport, Texas. The company...

  10. Summary of Lateral-Control Research

    DTIC Science & Technology

    1947-01-01

    Murray, Harry E.? and Erwin, Mary A.: Hinge Moments of Sealed- Internal-Balance Arrangements for Control Surfaces. I-Theo- retical Investigation. NSCA ...Ailerons for a Wing with a Full-Span Flap Consist- ing of an Inboard Fowler and an Outboard Retractable Split Flap. NSCA ACR, March 1941. SUMMARY OF...dimensional ................. NSCA conventional (approx. 14 per- m ._ ...... .20 ................ .13 1. 91 cent thick). Semispan wing

  11. Multipoint Grout Injection System. Innovative Technology Summary Report

    SciTech Connect

    2001-09-01

    At the Oak Ridge Reservation (ORR), radioactive waste contained in the 16 cylindrical Gunite and Associated Tanks (GAATs) must retrieved so the tanks can be closed. In many cases, removing the small amounts of sludge that remain in the tank after the bulk of the waste is retrieved is extremely costly and provides little benefit from site health and environmental standpoints. The Tanks Focus Area is working with ORR's M and I contractor (Bechtel-Jacobs), Oak Ridge National Laboratory, and Ground Environmental Services to demonstrate the application of multi-point-injection (MPI) grout emplacement technology for horizontal cylindrical tanks during a cold demonstration in FY99. GAAT TH-4 has been identified as the tank to be used for the hot demonstration in FY00. Evaluation efforts continue on the effect of slag on strength performance of the grout to be used in TH-4 tank closure. The site must find out what level of slag can be accommodated in the grout while maintaining strength performance requirements. Other efforts in support of the utilization of MPI TM technology in large-scale waste tanks will continue. Also, ORR is collaborating with SRS to evaluate the use this technology to support grouting of the Old Burial Ground tanks at SRS.

  12. Summary of lateral-control research

    NASA Technical Reports Server (NTRS)

    Toll, Thomas A

    1947-01-01

    A summary has been made of the available information on lateral control. A discussion is given of the criterions used in lateral-control specifications, of the factors involved in obtaining satisfactory lateral control, and of the methods employed in making lateral-control investigations in flight and in wind tunnels. The available data on conventional flap-type ailerons having various types of aerodynamic balance are presented in a form convenient for use in design. The characteristics of spoiler devices and booster mechanisms are discussed. The effects of Mach number, boundary layer, and distortion of the wing or of the lateral-control system are considered insofar as the available information permits. An example is included to illustrate the use of the design data. The limitations of the available information and some of the lateral-control problems that remain to be solved are indicated.

  13. Impulsive Injection for Compressor Stator Separation Control

    NASA Technical Reports Server (NTRS)

    Culley, Dennis E.; Braunscheidel, Edward P.; Bright, Michelle M.

    2005-01-01

    Flow control using impulsive injection from the suction surface of a stator vane has been applied in a low speed axial compressor. Impulsive injection is shown to significantly reduce separation relative to steady injection for vanes that were induced to separate by an increase in vane stagger angle of 4 degrees. Injected flow was applied to the airfoil suction surface using spanwise slots pitched in the streamwise direction. Injection was limited to the near-hub region, from 10 to 36 percent of span, to affect the dominant loss due to hub leakage flow. Actuation was provided externally using high-speed solenoid valves closely coupled to the vane tip. Variations in injected mass, frequency, and duty cycle are explored. The local corrected total pressure loss across the vane at the lower span region was reduced by over 20 percent. Additionally, low momentum fluid migrating from the hub region toward the tip was effectively suppressed resulting in an overall benefit which reduced corrected area averaged loss through the passage by 4 percent. The injection mass fraction used for impulsive actuation was typically less than 0.1 percent of the compressor through flow.

  14. Mould temperature control during injection moulding process

    NASA Astrophysics Data System (ADS)

    Postawa, Przemyslaw; Stachowiak, Tomasz

    2015-05-01

    Mould temperature is one of the most important parameter in injection moulding process of thermoplastic polymers in particular semi crystalline polymers. There are a lots of methods of control mould temperature but it is not simple and easy to measure heat transfer precisely. Injection moulds have usually a large mass and this is equal also to large heat capacity of tools and its thermal inertia. Measuring temperature by using contact equipment causes a lot of mistakes, because that method is based on heat transfer between thermocouple and measured area of mould. Result of research of 3 different method of temperature control of mould surface were present in the publication. For this purpose a special experimental mould was made. Mould has eight independent cooling circuits which were connected to the thermo controller Wittmann with two circuits. The main aim of research was to determine the effect of normal process of injection moulding on temperature changing in different area of mould. Under the cavity 4 thermocouple were placed and connect to the recorder what gave a possibility of uploading data during injection process. For that research mould temperature was change in many different layouts. Data and sequences of changes in temperature collected during tests gave very interesting result for discussion. Furthermore use of differences in temperature profile of the mould causes different temperature profile recorded during injection moulding. Tests were made by using fallowing equipment: Krauss Maffei injection moulding machine KM65-C4 and thermo controller Wittmann TPplus2, Shini Rotameter, infrared camera TESTO-890 and thermocouple signal recorder with 4 thermocouples of diameter 1mm located in injection mould 3mm under cavity surface. Draft of experimental mould and thermocouple location were presented in the article, and results of research as a drafts and charts of temperature changing in different area of mould were included.

  15. Injectable controlled release depots for large molecules

    PubMed Central

    Schwendeman, Steven P.; Shah, Ronak B.; Bailey, Brittany A.; Schwendeman, Anna S.

    2014-01-01

    Biodegradable, injectable depot formulations for long-term controlled drug release have improved therapy for a number of drug molecules and led to over a dozen highly successful pharmaceutical products. Until now, success has been limited to several small molecules and peptides, although remarkable improvements have been accomplished in some of these cases. For example, twice-a-year depot injections with leuprolide are available compared to the once-a-day injection of the solution dosage form. Injectable depots are typically prepared by encapsulation of the drug in poly(lactic-co-glycolic acid) (PLGA), a polymer that is used in children every day as a resorbable suture material, and therefore, highly biocompatible. PLGAs remain today as one of the few “real world” biodegradable synthetic biomaterials used in US FDA-approved parenteral long-acting-release (LAR) products. Despite their success, there remain critical barriers to the more widespread use of PLGA LAR products, particularly for delivery of more peptides and other large molecular drugs, namely proteins. In this review, we describe key concepts in the development of injectable PLGA controlled-release depots for peptides and proteins, and then use this information to identify key issues impeding greater widespread use of PLGA depots for this class of drugs. Finally, we examine important approaches, particularly those developed in our research laboratory, toward overcoming these barriers to advance commercial LAR development. PMID:24929039

  16. Injectable controlled release depots for large molecules.

    PubMed

    Schwendeman, Steven P; Shah, Ronak B; Bailey, Brittany A; Schwendeman, Anna S

    2014-09-28

    Biodegradable, injectable depot formulations for long-term controlled drug release have improved therapy for a number of drug molecules and led to over a dozen highly successful pharmaceutical products. Until now, success has been limited to several small molecules and peptides, although remarkable improvements have been accomplished in some of these cases. For example, twice-a-year depot injections with leuprolide are available compared to the once-a-day injection of the solution dosage form. Injectable depots are typically prepared by encapsulation of the drug in poly(lactic-co-glycolic acid) (PLGA), a polymer that is used in children every day as a resorbable suture material, and therefore, highly biocompatible. PLGAs remain today as one of the few "real world" biodegradable synthetic biomaterials used in US FDA-approved parenteral long-acting-release (LAR) products. Despite their success, there remain critical barriers to the more widespread use of PLGA LARproducts, particularly for delivery of more peptides and other large molecular drugs, namely proteins. In this review, we describe key concepts in the development of injectable PLGA controlled-release depots for peptides and proteins, and then use this information to identify key issues impeding greater widespread use of PLGA depots for this class of drugs. Finally, we examine important approaches, particularly those developed in our research laboratory, toward overcoming these barriers to advance commercial LAR development.

  17. Passive injection control for microfluidic systems

    DOEpatents

    Paul, Phillip H.; Arnold, Don W.; Neyer, David W.

    2004-12-21

    Apparatus for eliminating siphoning, "dead" regions, and fluid concentration gradients in microscale analytical devices. In its most basic embodiment, the present invention affords passive injection control for both electric field-driven and pressure-driven systems by providing additional fluid flow channels or auxiliary channels disposed on either side of a sample separation column. The auxiliary channels are sized such that volumetric fluid flow rate through these channels, while sufficient to move the sample away from the sample injection region in a timely fashion, is less than that through the sample separation channel or chromatograph.

  18. Solenoid-valve-controlled fuel injection device

    SciTech Connect

    Oshizawa, H.

    1988-12-06

    This patent describes a solenoid-valve-controlled fuel injection device comprising: a fuel injection pump having a pump cylinder, a plunger rotatably and reciprocably disposed in the pump cylinder in a fluid-tight manner and defining a fuel pressurization chamber between a distal end of the plunger and the pump cylinder, a drive shaft rotatable in synchronism with an output shaft of an internal combustion engine, means responsive to rotation of the drive shaft for reciprocably displacing the plunger to pressurize fuel in the pressurization chamber, and a fuel chamber for being supplied with fuel from a fuel tank in response to rotation of the drive shaft, whereby the pressurized fuel can be fed into cylinders of the internal combustion engine; a solenoid valve for selectively opening and closing a communication passage by which the pressurization chamber and the fuel chamber communicate with each other; valve opening delay time detecting means for detecting a valve opening delay time of the solenoid valve; valve closing delay time detecting means for detecting a valve closing delay time of the solenoid valve; valve closing period calculating means for calculating a valve closing time of the solenoid valve according to operating conditions of the internal combustion engine; target fuel injection time calculating means for calculating a target fuel injection time according to the operating conditions of the internal combustion engine.

  19. 76 FR 42125 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... AGENCY Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection; ConocoPhillips Company, Borger, TX AGENCY: Environmental... Company for one Class I injection well located at Borger, Texas. The company has adequately...

  20. 76 FR 55908 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... AGENCY Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection; Great Lakes Chemical Corporation, El Dorado, AR AGENCY... granted to Great Lakes Chemical Corporation for two Class I injection wells located at El Dorado,...

  1. 76 FR 36129 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... AGENCY Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection; ExxonMobil Environmental Services Company, Pasadena TX AGENCY... Environmental Services Company for two Class I injection wells located at Pasadena, Texas. The company...

  2. 75 FR 60457 - Underground Injection Control Program Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... AGENCY Underground Injection Control Program Hazardous Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection Dow Chemical Company (DOW), Magnolia, AR AGENCY: Environmental... a Class I injection well located at Magnolia, Arkansas. As required by 40 CFR Part 148, the...

  3. 78 FR 42776 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... AGENCY Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection; Blanchard Refining Company LLC Galveston Bay Refinery, Texas... injection wells located at Texas City, Texas. The company has adequately demonstrated to the satisfaction...

  4. Electronically controlled distributor type fuel injection pump

    SciTech Connect

    Kobayashi, M.; Nozaki, S.; Kobayashi, T.

    1986-05-06

    A distributor type fuel injection pump is described which consists of: a plunger barrel; a plunger received within the plunger barrel for concurrent reciprocating and rotative motion for suction, pressure delivery and distribution of fuel; a pair of cut-off ports formed in the plunger and the plunger barrel at a predetermined axial location and registrable with each other to spill pressurized fuel in the plunger into a zone under lower pressure; a communication passageway communicating a pump working chamber defined by the plunger at one end thereof with the zone under lower pressure; a fuel suction passage extending between the pump working chamber and the zone under lower pressure; the communication passageway extending between the pump working chamber and an intermediate portion of the fuel suction passage; a solenoid valve arranged across the communication passageway for blocking same; and control means for controlling means for controlling the solenoid valve to cause same to selectively assume an open position and a closed position; wherein while the plunger moves toward the pump working chamber, the solenoid valve is closed by the control means to start injection of fuel present in the pump working chamber, and upon registration of the cut-off ports with each other, the fuel injection is terminated; the solenoid valve including a valve body disposed opposite an end face of the one end of the plunger; the control means including means for selectively energizing or deenergizing the solenoid for causing the valve body to selectively assume the closed position or the open position.

  5. Steam injection profile control agent and process

    SciTech Connect

    Shu, P.

    1992-04-14

    This patent describes a method for controlling a formation's profile where temperatures higher than 400 degrees F. are encountered in a substantially silica or sand containing formation, it comprises: injecting an aqueous solution of an alkali metal silicate into a zone of higher permeability; injecting a solvent solution containing a calcium salt in an amount sufficient to react with the alkali metal silicate as the solvent solution flows a front evenly through the zone thereby forming a calcium silicate cement which binds silica containing particles in the zone while decreasing the permeability of the zone and retaining a desired permeability of the higher permeability zone; and initiating a thermal oil recovery method in a zone of lesser permeability within the formation and removing hydrocarbonaceous fluids therefrom where the recovery method causes the formation to be heated to a temperature in excess of about 400 degrees F.

  6. Influence of pre-injection control parameters on main-injection fuel quantity for an electronically controlled double-valve fuel injection system of diesel engine

    NASA Astrophysics Data System (ADS)

    Song, Enzhe; Fan, Liyun; Chen, Chao; Dong, Quan; Ma, Xiuzhen; Bai, Yun

    2013-09-01

    A simulation model of an electronically controlled two solenoid valve fuel injection system for a diesel engine is established in the AMESim environment. The accuracy of the model is validated through comparison with experimental data. The influence of pre-injection control parameters on main-injection quantity under different control modes is analyzed. In the spill control valve mode, main-injection fuel quantity decreases gradually and then reaches a stable level because of the increase in multi-injection dwell time. In the needle control valve mode, main-injection fuel quantity increases with rising multi-injection dwell time; this effect becomes more obvious at high-speed revolutions and large main-injection pulse widths. Pre-injection pulse width has no obvious influence on main-injection quantity under the two control modes; the variation in main-injection quantity is in the range of 1 mm3.

  7. Fuel injection pump with spill control mechanism

    SciTech Connect

    Djordjevic, I.

    1987-02-24

    This patent describes a rotary fuel injection pump for an internal combustion engine, having a housing, a rotor rotatable in the housing, a charge pump having radially extending plunger bores in the rotor and a plunger pump for each plunger bore having a pumping plunger reciprocable in the bore. The pumping plungers have outward fuel intake strokes and inward fuel delivery strokes for supplying high pressure charges of fuel for fuel injection. A cam ring surrounds the rotor and is engageable with the plunger pumps to reciprocate the plungers as the rotor rotates. Bumping plunger timing means relatively angularly adjusts the cam ring and rotor adjusting the pumping plunger timing. A spill control mechanism has spill valve means connected to the charge pump for spill control of the high pressure charges of fuel. The improvement described here wherein the spill valve means comprises at least one rotary spill valve having a valve bore in the rotor connected to the charge pump and a rotary spill valve member rotatably mounted within the valve bore. The spill control mechanism comprises first means for rotating each rotary spill valve member in unison with the rotor and in synchronism with the reciprocable movement of the pumping plungers for spill control of the high pressure charges of fuel. The pumping plunger timing means and the first means provide for separate relative angular adjustment of the cam ring and rotor and relative angular adjustment of the rotary spill valve member of at least the one rotary spill valve and the rotor.

  8. Dynamic Feed Control For Injection Molding

    DOEpatents

    Kazmer, David O.

    1996-09-17

    The invention provides methods and apparatus in which mold material flows through a gate into a mold cavity that defines the shape of a desired part. An adjustable valve is provided that is operable to change dynamically the effective size of the gate to control the flow of mold material through the gate. The valve is adjustable while the mold material is flowing through the gate into the mold cavity. A sensor is provided for sensing a process condition while the part is being molded. During molding, the valve is adjusted based at least in part on information from the sensor. In the preferred embodiment, the adjustable valve is controlled by a digital computer, which includes circuitry for acquiring data from the sensor, processing circuitry for computing a desired position of the valve based on the data from the sensor and a control data file containing target process conditions, and control circuitry for generating signals to control a valve driver to adjust the position of the valve. More complex embodiments include a plurality of gates, sensors, and controllable valves. Each valve is individually controllable so that process conditions corresponding to each gate can be adjusted independently. This allows for great flexibility in the control of injection molding to produce complex, high-quality parts.

  9. Control Class Summaries and Control Class IV from April 1990

    SciTech Connect

    Wu, J.; /Fermilab

    1991-02-22

    The D0 cryogenic control system is a complicated system with many facets. Because of the large number and variety of features in the system, a series of ongoing control system training seminars, or control classes, were created in order to keep people up to date on the operation of the system. As of the writing of this engineering note, there have been four classes. The original lecture notes from each class can be found in the cryogenic control room at the D0 Assembly Building, or in the Co-op office. This note provides a summary of the first three control classes, and it includes the entire set of notes from the fourth class, which was held in April of 1990. This class was taught by Jeff Wendlandt and Dan Markley. Dan should be consulted for more complete explanations than those given in the notes. The notes are, in fact, more of a reference for someone who has some experience with the system, than they are a training manual. Most of the pages include pictures and printouts of different menus and functions, useful for finding details without searching through the actual program. In general, this note serves as a pointer to the existence of the control class lecture notes, and as an explanation of their overall contents and purpose.

  10. Variable stroke, electronically controlled fuel injection control system

    SciTech Connect

    O'Neill, C.G.

    1987-02-17

    A fuel injection control system is described comprising an internal combustion engine having a crankshaft, a fuel supply, a spill valve in fluid communication with the fuel supply, a fuel injection nozzle, a fuel pump comprising a piston and cylinder, the cylinder in fluid communication with the fuel injection nozzle and the spill valve, means for actuating the fuel pump piston comprises means for actuating the fuel pump piston to achieve a constant velocity relative to angular rotation of the crankshaft for the piston during the delivery portion of the pumpstroke during the travel of the piston in the cylinder, means for closing the spill valve when the piston, during the delivery portion of the pumpstroke, reaches a first predetermined position in the fuel pump cylinder and opening the spill valve when the piston, during the delivery portion, reaches a second predetermined position in the fuel pump cylinder.

  11. Evaluation of Sorbent Injection for Mercury Control

    SciTech Connect

    Sharon Sjostrom

    2005-12-30

    The power industry in the U.S. is faced with meeting new regulations to reduce the emissions of mercury compounds from coal-fired plants. These regulations are directed at the existing fleet of nearly 1,100 boilers. These plants are relatively old with an average age of over 40 years. Although most of these units are capable of operating for many additional years, there is a desire to minimize large capital expenditures because of the reduced (and unknown) remaining life of the plant to amortize the project. Injecting a sorbent such as powdered activated carbon into the flue gas represents one of the simplest and most mature approaches to controlling mercury emissions from coal-fired boilers. This is the final site report for tests conducted at Laramie River Station Unit 3, one of five sites evaluated in this DOE/NETL program. The overall objective of the test program is to evaluate the capabilities of activated carbon injection at five plants: Sunflower Electric's Holcomb Station Unit 1, AmerenUE's Meramec Station Unit 2, Missouri Basin Power Project's Laramie River Station Unit 3, Detroit Edison's Monroe Power Plant Unit 4, and AEP's Conesville Station Unit 6. These plants have configurations that together represent 78% of the existing coal-fired generation plants. The goals for the program established by DOE/NETL are to reduce the uncontrolled mercury emissions by 50 to 70% at a cost 25 to 50% lower than the benchmark established by DOE of $60,000/lb mercury removed. The goals of the program were exceeded at Laramie River Station by achieving over 90% mercury removal at a sorbent cost of $3,980/lb ($660/oz) mercury removed for a coal mercury content of 7.9 lb/TBtu.

  12. Dynamics and controls working group summary

    NASA Technical Reports Server (NTRS)

    Oglevie, R. E.

    1984-01-01

    The technology status of the dynamics and controls discipline as it applies to energy storage wheel systems was evaluated. No problems were identified for which an adequate solution could not be proposed. Design issues that influence control were addressed. The dynamics and control aspects associated with the energy storage system concept and its various constituent parts, and the control tasks attendant to large, manned spacecraft are discussed.

  13. Electrokinetically controlled fluid injection into unicellular microalgae.

    PubMed

    Zhou, Xuewen; Zhang, Xixi; Boualavong, Jonathan; Durney, Andrew R; Wang, Tonghui; Kirschner, Scott; Wentz, Michaela; Mukaibo, Hitomi

    2017-04-04

    Electrokinetically-controlled microinjection is reported as an effective transport mechanism for microinjection into the wild-type strain of the widely-studied model microalga Chlamydomonas reinhardtii. Microinjection system using glass capillary pipettes was developed to capture and impale the motile cell. To apply an electric field and induce electrokinetic flow (e.g. electrophoresis and electroosmosis), an electrode was inserted directly to the solution inside the impaling injection pipette (IP) and another electrode was inserted into the external cell media. The viability of the impaled cells was confirmed for more than an hour under 0.01 V using the fluorescein diacetate (FDA)/propidium iodide (PI) dual fluorescent dye-based assay. The viability was also found to increase almost logarithmically with decreasing voltage and to depend strongly on the solution within the IP. Successful electrokinetic microinjection into the cell was confirmed by both the increase in the cell volume under an applied voltage and the electric-field dependent delivery of fluorescent fluorescein molecule into an impaled cell. Our study offers novel opportunities for quantitative delivery of biomolecules into microalgae and advancing the research and development of these organisms as biosynthetic factories. This article is protected by copyright. All rights reserved.

  14. Evaluation of Sorbent Injection for Mercury Control

    SciTech Connect

    Sharon Sjostrom

    2008-06-30

    ADA-ES, Inc., with support from DOE/NETL, EPRI, and industry partners, studied mercury control options at six coal-fired power plants. The overall objective of the this test program was to evaluate the capabilities of activated carbon injection at six plants: Sunflower Electric's Holcomb Station Unit 1, AmerenUE's Meramec Station Unit 2, Missouri Basin Power Project's Laramie River Station Unit 3, Detroit Edison's Monroe Power Plant Unit 4, American Electric Power's Conesville Station Unit 6, and Labadie Power Plant Unit 2. These plants have configurations that together represent 78% of the existing coal-fired generation plants. The financial goals for the program established by DOE/NETL were to reduce the uncontrolled mercury emissions by 50 to 70% at a cost 25 to 50% lower than the target established by DOE of $60,000 per pound of mercury removed. Results from testing at Holcomb, Laramie, Meramec, Labadie, and Monroe indicate the DOE goal was successfully achieved. However, further improvements for plants with conditions similar to Conesville are recommended that would improve both mercury removal performance and economics.

  15. Evaluation of Sorbent Injection for Mercury Control

    SciTech Connect

    Sharon Sjostrom

    2006-04-30

    The power industry in the U.S. is faced with meeting new regulations to reduce the emissions of mercury compounds from coal-fired plants. These regulations are directed at the existing fleet of nearly 1,100 boilers. These plants are relatively old with an average age of over 40 years. Although most of these units are capable of operating for many additional years, there is a desire to minimize large capital expenditures because of the reduced (and unknown) remaining life of the plant to amortize the project. Injecting a sorbent such as powdered activated carbon into the flue gas represents one of the simplest and most mature approaches to controlling mercury emissions from coal-fired boilers. This is the final site report for tests conducted at DTE Energy's Monroe Power Plant, one of five sites evaluated in this DOE/NETL program. The overall objective of the test program was to evaluate the capabilities of activated carbon injection at five plants: Sunflower Electric's Holcomb Station Unit 1, AmerenUE's Meramec Station Unit 2, Missouri Basin Power Project's Laramie River Station Unit 3, Detroit Edison's Monroe Power Plant Unit 4, and AEP's Conesville Station Unit 6. These plants have configurations that together represent 78% of the existing coal-fired generation plants. The goals for the program established by DOE/NETL were to reduce the uncontrolled mercury emissions by 50 to 70% at a cost 25 to 50% lower than the target established by DOE of $60,000/lb mercury removed. The results from Monroe indicate that using DARCO{reg_sign} Hg would result in higher mercury removal (80%) at a sorbent cost of $18,000/lb mercury, or 70% lower than the benchmark. These results demonstrate that the goals established by DOE/NETL were exceeded during this test program. The increase in mercury removal over baseline conditions is defined for this program as a comparison in the outlet emissions measured using the Ontario Hydro method during the baseline and long-term test periods

  16. Evaluation of Sorbent Injection for Mercury Control

    SciTech Connect

    Sharon Sjostrom

    2005-02-02

    The power industry in the U.S. is faced with meeting new regulations to reduce the emissions of mercury compounds from coal-fired plants. These regulations are directed at the existing fleet of nearly 1,100 boilers. These plants are relatively old with an average age of over 40 years. Although most of these units are capable of operating for many additional years, there is a desire to minimize large capital expenditures because of the reduced (and unknown) remaining life of the plant to amortize the project. Injecting a sorbent such as powdered activated carbon into the flue gas represents one of the simplest and most mature approaches to controlling mercury emissions from coal-fired boilers. The overall objective of the test program described in this quarterly report is to evaluate the capabilities of activated carbon injection at five plants with configurations that together represent 78% of the existing coal-fired generation plants. This technology was successfully evaluated in NETL's Phase I tests at scales up to 150 MW, on plants burning subbituminous and bituminous coals and with ESPs and fabric filters. The tests also identified issues that still need to be addressed, such as evaluating performance on other configurations, optimizing sorbent usage (costs), and gathering longer-term operating data to address concerns about the impact of activated carbon on plant equipment and operations. The four sites identified for testing are Sunflower Electric's Holcomb Station, AmerenUE's Meramec Station, AEP's Conesville Station, and Detroit Edison's Monroe Power Plant. In addition to tests identified for the four main sites, parametric testing at Missouri Basin Power Project's Laramie River Station Unit 3 has been scheduled and made possible through additional costshare participation targeted by team members specifically for tests at Holcomb or a similar plant. This is the fifth quarterly report for this project. Long-term testing was completed at Meramec during this

  17. Evaluation of Sorbent Injection for Mercury Control

    SciTech Connect

    Sharon Sjostrom

    2004-10-29

    The power industry in the U.S. is faced with meeting new regulations to reduce the emissions of mercury compounds from coal-fired plants. These regulations are directed at the existing fleet of nearly 1,100 boilers. These plants are relatively old with an average age of over 40 years. Although most of these units are capable of operating for many additional years, there is a desire to minimize large capital expenditures because of the reduced (and unknown) remaining life of the plant to amortize the project. Injecting a sorbent such as powdered activated carbon into the flue gas represents one of the simplest and most mature approaches to controlling mercury emissions from coal-fired boilers. The overall objective of the test program described in this quarterly report is to evaluate the capabilities of activated carbon injection at four plants with configurations that together represent 78% of the existing coal-fired generation plants. This technology was successfully evaluated in NETL's Phase I tests at scales up to 150 MW, on plants burning subbituminous and bituminous coals and with ESPs and fabric filters. The tests also identified issues that still need to be addressed, such as evaluating performance on other configurations, optimizing sorbent usage (costs), and gathering longer-term operating data to address concerns about the impact of activated carbon on plant equipment and operations. The four sites identified for testing are Sunflower Electric's Holcomb Station, AmerenUE's Meramec Station, AEP's Conesville Station, and a site burning a blend of bituminous and subbituminous coals with a cold-side ESP. This is the fourth quarterly report for this project. Long-term testing was completed at Holcomb during this reporting period and baseline testing at Meramec was begun. Preliminary results from long-term testing at Holcomb are included in this report. Planning information for the other three sites is also included. In general, quarterly reports will be used

  18. Alkaline sorbent injection for mercury control

    DOEpatents

    Madden, Deborah A.; Holmes, Michael J.

    2002-01-01

    A mercury removal system for removing mercury from combustion flue gases is provided in which alkaline sorbents at generally extremely low stoichiometric molar ratios of alkaline earth or an alkali metal to sulfur of less than 1.0 are injected into a power plant system at one or more locations to remove at least between about 40% and 60% of the mercury content from combustion flue gases. Small amounts of alkaline sorbents are injected into the flue gas stream at a relatively low rate. A particulate filter is used to remove mercury-containing particles downstream of each injection point used in the power plant system.

  19. Alkaline sorbent injection for mercury control

    DOEpatents

    Madden, Deborah A.; Holmes, Michael J.

    2003-01-01

    A mercury removal system for removing mercury from combustion flue gases is provided in which alkaline sorbents at generally extremely low stoichiometric molar ratios of alkaline earth or an alkali metal to sulfur of less than 1.0 are injected into a power plant system at one or more locations to remove at least between about 40% and 60% of the mercury content from combustion flue gases. Small amounts of alkaline sorbents are injected into the flue gas stream at a relatively low rate. A particulate filter is used to remove mercury-containing particles downstream of each injection point used in the power plant system.

  20. Diesel engine fuel injection system with a rate-of-injection control arrangement

    SciTech Connect

    Abe, S.; Igashira, T.; Sakakibara, Y.; Izawa, A.; Sekiguchi, K.

    1988-03-15

    A fuel injection system for a diesel engine is described comprising: (a) a fuel injection pump for delivering a controlled quantity of high pressure fuel cyclically at a timing synchronized with the operation of the engine; (b) a fuel injection nozzle hydraulically connected to the injection pump for receiving high pressure fuel therefrom and injecting the fuel into an engine cylinder; (c) means for controlling a rate of injection of the system in response to operating conditions of the engine; and (d) passage means for providing, during each delivery stroke of the pump plunger, fluid communication between the pumping chamber and the variable volume chamber only for a predetermined initial phase of the delivery stroke. The variable volume chamber is hydraulically isolated from the pumping chamber during subsequent phases of the delivery stroke.

  1. National Drug Control Strategy. FY 2009 Budget Summary

    ERIC Educational Resources Information Center

    The White House, 2008

    2008-01-01

    The National Drug Control Budget Summary identifies resources and performance indicators for programs within the Executive Branch that are integral to the President's National Drug Control Strategy. The Strategy, which is the Administration's plan for reducing drug use and availability, is based on three pillars: (1) Stopping Use Before It Starts,…

  2. Distributed Energy Communications & Controls, Lab Activities - Summary

    SciTech Connect

    Rizy, D Tom

    2010-01-01

    The purpose is to develop controls for inverter-based renewable and non-renewable distributed energy systems to provide local voltage, power and power quality support for loads and the power grid. The objectives are to (1) develop adaptive controls for inverter-based distributed energy (DE) systems when there are multiple inverters on the same feeder and (2) determine the impact of high penetration high seasonal energy efficiency ratio (SEER) air conditioning (A/C) units on power systems during sub-transmission faults which can result in an A/C compressor motor stall and assess how inverter-based DE can help to mitigate the stall event. The Distributed Energy Communications & Controls Laboratory (DECC) is a unique facility for studying dynamic voltage, active power (P), non-active power (Q) and power factor control from inverter-based renewable distributed energy (DE) resources. Conventionally, inverter-based DE systems have been designed to provide constant, close to unity power factor and thus not provide any voltage support. The DECC Lab interfaces with the ORNL campus distribution system to provide actual power system testing of the controls approach. Using mathematical software tools and the DECC Lab environment, we are developing and testing local, autonomous and adaptive controls for local voltage control and P & Q control for inverter-based DE. We successfully tested our active and non-active power (P,Q) controls at the DECC laboratory along with voltage regulation controls. The new PQ control along with current limiter controls has been tested on our existing inverter test system. We have tested both non-adaptive and adaptive control modes for the PQ control. We have completed several technical papers on the approaches and results. Electric power distribution systems are experiencing outages due to a phenomenon known as fault induced delayed voltage recovery (FIDVR) due to air conditioning (A/C) compressor motor stall. Local voltage collapse from FIDVR is

  3. Sensors and Controls Workshop Summary Report

    SciTech Connect

    Susan Maley; Robert R. Romanosky

    2001-11-30

    Higher operating efficiencies, emission reductions, improved reliability, and lower operating costs are benefits that the power industry can realize with the utilization of sensors and controls. However, for the power industry to derive the maximum benefit from sensors and controls, improvements in existing technologies and novel approaches to challenging measurements are needed. Recognizing the importance of sensors and controls, the U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL) sponsored a sensors and controls workshop on April 17 to 18, 2001, in Washington, DC. The workshop focused on identifying technology needs in sensors and controls for existing fossil-energy power plants as well as future facilities conceived under the Vision 21 Program. Forty-six experts from 29 organizations, including private industry, research laboratories, academia, and government agencies, attended the workshop. The meeting opened with keynote speakers from NETL and the private sector. NETL officials spoke of the Vision 21 and advanced research programs. Speakers from the Electric Power Research Institute (EPRI) and Delphi Automotive Systems Research Laboratory discussed the improvements realized with their respective operation through the use of sensors and controls. NETL keynote speakers Robert Romanosky and Carl Bauer emphasized that developing sensor and control systems plays a critical role in DOE Office of Fossil Energy Vision 21 Program, clean coal activities under the Power Plant Improvement Initiative, and the proposed Clean Coal Power Initiative. The Vision 21 Program is aimed at providing technologies for ultra-clean fossil-fuel-based energy production with 60- to 75-percent efficiencies and near zero emissions. The program also uses a modular approach to present opportunities to not only generate power, but also co-produce clean fuels, chemicals, steam, and other useful products. The ultra-high efficiency and environmental performance goals

  4. 2011 National Drug Control Strategy. Executive Summary

    ERIC Educational Resources Information Center

    Office of National Drug Control Policy, 2011

    2011-01-01

    In May of 2010, President Obama released the Administration's inaugural "National Drug Control Strategy", a comprehensive approach to combat the public health and safety consequences posed by drug use. Now, a year later, the Administration is releasing its update building upon that initial "Strategy". The "Strategy" establishes ambitious goals to…

  5. Helicopter roll control effectiveness criteria program summary

    NASA Technical Reports Server (NTRS)

    Heffley, Robert K.; Bourne, Simon M.; Mnich, Marc A.

    1988-01-01

    A study of helicopter roll control effectiveness is summarized for the purpose of defining military helicopter handling qualities requirements. The study is based on an analysis of pilot-in-the-loop task performance of several basic maneuvers. This is extended by a series of piloted simulations using the NASA Ames Vertical Motion Simulator and selected flight data. The main results cover roll control power and short-term response characteristics. In general the handling qualities requirements recommended are set in conjunction with desired levels of flight task and maneuver response which can be directly observed in actual flight. An important aspect of this, however, is that vehicle handling qualities need to be set with regard to some quantitative aspect of mission performance. Specific examples of how this can be accomplished include a lateral unmask/remask maneuver in the presence of a threat and an air tracking maneuver which recognizes the kill probability enhancement connected with decreasing the range to the target. Conclusions and recommendations address not only the handling qualities recommendations, but also the general use of flight simulators and the dependence of mission performance on handling qualities.

  6. Method for controlling corrosion in thermal vapor injection gases

    DOEpatents

    Sperry, John S.; Krajicek, Richard W.

    1981-01-01

    An improvement in the method for producing high pressure thermal vapor streams from combustion gases for injection into subterranean oil producing formations to stimulate the production of viscous minerals is described. The improvement involves controlling corrosion in such thermal vapor gases by injecting water near the flame in the combustion zone and injecting ammonia into a vapor producing vessel to contact the combustion gases exiting the combustion chamber.

  7. Fuel injection control apparatus for use to engine

    SciTech Connect

    Kato, M.; Kano, H.; Ohmori, T.

    1987-06-30

    A fuel injection control apparatus is described for use in an engine comprising: a compression plunger driven in response to fuel injection timing which corresponds to the rotation of an engine; a compression pump chamber which is filled with fuel and whose volume is compressed when the compression plunger is driven; an injection plunger driven by fuel which is pushed out of the compression pump chamber by the operation of the compression plunger; an injection pump chamber defined by the injection plunger; means for filling the injection pump chamber with fuel whose amount has been determined in accordance with the conditions of the operation of the engine; a timing plunger slidable between a stop position and a full position, the amount of fuel the filling means provides to the injection pump chamber cooperating with the injection plunger to mechanically set the timing plunger at the full position corresponding to the amount of fuel to be injected. The timing plunger contacts the face on which the fuel pressure in the compression pump chamber acts at the full position when the compression plunger is not driven, the fuel in the compression pump chamber moves the timing plunger as fuel is pushed out of the compression pump chamber. The fuel pressure in the compression pump chamber acts on the injection plunger when the timing plunger is moved to the stop position; and fuel injection means, responsive to the operation of the compression plunger, for moving the timing plunger from the full position to the stop position, then raising the pressure of the compression pump chamber to drive the injection plunger. In this high pressure state it delivers the fuel in the injection pump chamber and injects it into an engine cylinder.

  8. Electromagnetically controlled distributor-type fuel injection system

    SciTech Connect

    Schechter, M.M.; Levin, M.B.; Dutcher, W.R. Jr.

    1989-01-01

    With the advent of electronic controls and development of electromagnetically controlled fuel injection pumps, the cost of fuel systems using plunger-type pumps was substantially reduced. Further reduction in cost can be achieved if fewer solenoid valves are used. A new type of injection pump combining electromagnetic spill control principle with distributor-type operation is described. A review of the basic concept and operating principles is given, and test results as well as cost considerations are discussed.

  9. Omni-axis secondary injection thrust vector control system

    NASA Technical Reports Server (NTRS)

    Kirkley, D. J.

    1973-01-01

    The concept, development, design study and preliminary analysis and layout of the required digital logic scheme to be used for injection valve control are presented. An application and optimization study of an Omni-Axis Secondary Injection Control System applicable to the proposed Space Shuttle Pressure Fed Engine is reported. Technical definition and analysis control procedures and test routines, as well as a supporting set of drawing sketches and reference manual, are enclosed.

  10. Closed-Loop Control of Chemical Injection Rate for a Direct Nozzle Injection System.

    PubMed

    Cai, Xiang; Walgenbach, Martin; Doerpmond, Malte; Schulze Lammers, Peter; Sun, Yurui

    2016-01-20

    To realize site-specific and variable-rate application of agricultural pesticides, accurately metering and controlling the chemical injection rate is necessary. This study presents a prototype of a direct nozzle injection system (DNIS) by which chemical concentration transport lag was greatly reduced. In this system, a rapid-reacting solenoid valve (RRV) was utilized for injecting chemicals, driven by a pulse-width modulation (PWM) signal at 100 Hz, so with varying pulse width the chemical injection rate could be adjusted. Meanwhile, a closed-loop control strategy, proportional-integral-derivative (PID) method, was applied for metering and stabilizing the chemical injection rate. In order to measure chemical flow rates and input them into the controller as a feedback in real-time, a thermodynamic flowmeter that was independent of chemical viscosity was used. Laboratory tests were conducted to assess the performance of DNIS and PID control strategy. Due to the nonlinear input-output characteristics of the RRV, a two-phase PID control process obtained better effects as compared with single PID control strategy. Test results also indicated that the set-point chemical flow rate could be achieved within less than 4 s, and the output stability was improved compared to the case without control strategy.

  11. Closed-Loop Control of Chemical Injection Rate for a Direct Nozzle Injection System

    PubMed Central

    Cai, Xiang; Walgenbach, Martin; Doerpmond, Malte; Schulze Lammers, Peter; Sun, Yurui

    2016-01-01

    To realize site-specific and variable-rate application of agricultural pesticides, accurately metering and controlling the chemical injection rate is necessary. This study presents a prototype of a direct nozzle injection system (DNIS) by which chemical concentration transport lag was greatly reduced. In this system, a rapid-reacting solenoid valve (RRV) was utilized for injecting chemicals, driven by a pulse-width modulation (PWM) signal at 100 Hz, so with varying pulse width the chemical injection rate could be adjusted. Meanwhile, a closed-loop control strategy, proportional-integral-derivative (PID) method, was applied for metering and stabilizing the chemical injection rate. In order to measure chemical flow rates and input them into the controller as a feedback in real-time, a thermodynamic flowmeter that was independent of chemical viscosity was used. Laboratory tests were conducted to assess the performance of DNIS and PID control strategy. Due to the nonlinear input–output characteristics of the RRV, a two-phase PID control process obtained better effects as compared with single PID control strategy. Test results also indicated that the set-point chemical flow rate could be achieved within less than 4 s, and the output stability was improved compared to the case without control strategy. PMID:26805833

  12. SLIC Simulation-Based Liquid Injection Control

    DTIC Science & Technology

    2007-11-02

    Artificial Intelligence Optimized Design For RTM / VARTM Sensors & Recognition Algorithms Process Monitoring Control Algorithms Feedback Control...of Online Flow Control Solution Advantages of developing RTM / VARTM with SLIC • Rapid design for RTM / VARTM . • Less cost for process development...User Manual • Examples • Tutorials Probability Model FASTRAC Flow Control in VARTM RTM Light Optimization Preform Distribution Media 1 Jul 2003

  13. Field Demonstration of Enhanced Sorbent Injection for Mercury Control

    SciTech Connect

    Shin Kang; Robert Schrecengost

    2009-01-07

    Alstom Power Inc. has conducted a DOE/NETL-sponsored program (under DOE Cooperative Agreement No. DE-FC26-04NT42306) to demonstrate Mer-Cure{trademark}, one of Alstom's mercury control technologies for coal-fired boilers. Mer-Cure{trademark} utilizes a small amount of Mer-Clean{trademark} sorbent that is injected into the flue gas stream for oxidation and adsorption of gaseous mercury. Mer-Clean{trademark} sorbents are carbon-based and prepared with chemical additives that promote oxidation and capture of mercury. Mer-Cure{trademark} is unique in that the sorbent is injected into an environment where the mercury capture kinetics is accelerated. This full-scale demonstration program was comprised of three seven-week long test campaigns at three host sites including PacifiCorp's 240-MW{sub e} Dave Johnston Unit No.3 burning a Powder River Basin (PRB) coal, Basin Electric's 220-MW{sub e} Leland Olds Unit No.1 burning a North Dakota lignite, and Reliant Energy's 170-MW{sub e} Portland Unit No.1 burning an Eastern bituminous coal. All three boilers are equipped with electrostatic precipitators. The goals for this Round 2 program, established by DOE/NETL under the original solicitation, were to reduce the uncontrolled mercury emissions by 50 to 70% at a cost 25 to 50% lower than the previous target of $60,000/lb mercury removed. The results for all three host sites indicated that Mer-Cure{trademark} technology could achieve mercury removal of 90%. The estimated mercury removal costs were 25-92% lower than the benchmark of $60,000/lb mercury removed. The estimated costs for control, at sorbent cost of $1.25 to $2.00/lb respectively, are as follows: (1) Dave Johnston Unit No.3--$2,650 to $4,328/lb Hg removed (92.8% less than $60k/lb); (2) Leland Olds Unit No.1--$8,680 to $13,860/lb Hg removed (76.7% less than $60k/lb); and (3) Portland Unit No.1--$28,540 to $45,065/lb Hg removed (24.9% less than $60k/lb). In summary, the results from demonstration testing at all three host

  14. Summary

    NASA Astrophysics Data System (ADS)

    Habing, H.

    2004-07-01

    Summaries of conferences consist of subjective views of the reviewer, on what he remarked, of what he thought was important. And yet some of these remarks may be of interest to all participants. The event called "inspiration" may happen when scientist A gets an idea because of a brilliant or of stupid remark she heard when scientist B gave a summary. So, what is a good review? A review that broadens the perspective of at least some people in the audience. I hope that my attempt works. Let's see.

  15. [Development of the remote hydraulic pressure control injection].

    PubMed

    Wang, Di-le; Li, Ming-jie; He, Tao; Zheng, Zhi; Duan, Xin; Zheng, Ying-jian

    2009-01-01

    This paper introduced the work principle, execution, use and major characteristics of the remote hydraulic pressure control injection. Using Pascal principle, it is more accurate, convenient, cheap and safe. It could be used in all the fields of the medicine.

  16. Distributor-type fuel injection pump with preliminary injection control device

    SciTech Connect

    Taira, S.; Ishibashi, T.

    1987-01-13

    A distributor-type fuel injection pump is described for an internal combustion engine having at least one cylinder, the fuel injection pump comprising: (a) a housing having a fuel chamber defined therein; (b) fuel supply means for supplying fuel to the fuel chamber under pressure dependent upon engine r.p.m.; (c) a barrel mounted within the housing and having a distribution hole communicating with the engine cylinder; (d) a plunger mounted within the barrel for axial and rotary motion therein and defining jointly with the barrel a pump working chamber communicating with the fuel chamber. The plunger has a main discharge port communicating at one end with the pump working chamber and alignable with the distribution hole for effecting a main fuel injection, and a preliminary discharge port communicating with the pump working chamber and alignable with the distribution hole before the alignment of the main discharge port with the distribution hole, thereby effecting a preliminary fuel injection before the main injection; and (e) means operatively connected with the plunger and actuatable in response to pressure within the fuel chamber, for controlling fuel injection timing. The control means includes a first means, actuatable in response to the pressure within the fuel chamber, for effecting the preliminary fuel injection when the pressure within the fuel chamber is at less than a predetermined value, and a second means, actuatable in response to the pressure within the fuel chamber, for preventing the preliminary fuel injection when the pressure within the fuel chamber is above the predetermined value.

  17. A Summary of Some Discrete-Event System Control Problems

    NASA Astrophysics Data System (ADS)

    Rudie, Karen

    A summary of the area of control of discrete-event systems is given. In this research area, automata and formal language theory is used as a tool to model physical problems that arise in technological and industrial systems. The key ingredients to discrete-event control problems are a process that can be modeled by an automaton, events in that process that cannot be disabled or prevented from occurring, and a controlling agent that manipulates the events that can be disabled to guarantee that the process under control either generates all the strings in some prescribed language or as many strings as possible in some prescribed language. When multiple controlling agents act on a process, decentralized control problems arise. In decentralized discrete-event systems, it is presumed that the agents effecting control cannot each see all event occurrences. Partial observation leads to some problems that cannot be solved in polynomial time and some others that are not even decidable.

  18. Progestin-Only Hormonal Birth Control: Pill and Injection

    MedlinePlus

    ... in progestin-only pills and the birth control injection. The birth control implant and the hormonal intrauterine device also are progestin-only forms of birth control and are discussed in FAQ Long-Acting Reversible Contraception (LARC): IUD and Implant. How effective ...

  19. Separation Control in a Multistage Compressor Using Impulsive Surface Injection

    NASA Technical Reports Server (NTRS)

    Wundrow, David W.; Braunscheidel, Edward P.; Culley, Dennis E.; Bright, Michelle M.

    2006-01-01

    Control of flow separation using impulsive surface injection is investigated within the multistage environment of a low speed axial-flow compressor. Measured wake profiles behind a set of embedded stator vanes treated with suction-surface injection indicate significant reduction in flow separation at a variety of injection-pulse repetition rates and durations. The corresponding total pressure losses across the vanes reveal a bank of repetition rates at each pulse duration where the separation control remains nearly complete. This persistence allows for demands on the injected-mass delivery system to be economized while still achieving effective flow control. The response of the stator-vane boundary layers to infrequently applied short injection pulses is described in terms of the periodic excitation of turbulent strips whose growth and propagation characteristics dictate the lower bound on the band of optimal pulse repetition rates. The eventual falloff in separation control at higher repetition rates is linked to a competition between the benefits of pulse-induced mixing and the aggravation caused by the periodic introduction of low-momentum fluid. Use of these observations for impulsive actuator design is discussed and their impact on modeling the time-average effect of impulsive surface injection for multistage steady-flow simulation is considered.

  20. Injection timing control device for distributor-type fuel injection pumps

    SciTech Connect

    Sakuranaka, T.

    1986-09-09

    This patent describes an injection timing control device for combination with a fuel injection pump for an internal combustion engine, the pump being of the type having a suction space filled with fuel under pressure variable as a function of the rotational speed of the engine, a pumping and distributing plunger, and a roller holder carrying rollers circumferentially arranged and disposed in camming engagement with the plunger the injection timing control device comprising: a cylinder; a timer piston slidably received within the cylinder. The timer piston is coupled to the roller holder such that displacement thereof causes a corresponding change in the cicumferential position of the roller holder,; a first chamber defined at one end of the timer piston; a second chamber defined at one end of the timer piston; a second chamber defined at an opposite end of the timer piston.

  1. Fuel injection control apparatus for use in an engine

    SciTech Connect

    Kato, M.; Nishimaki, H.; Omori, T.; Sekijima, H.

    1988-07-26

    A fuel injection control apparatus for use in an engine is described including: a compression plunger, defining a compression pump chamber and driven in accordance with the rotation of the engine, for expelling fuel filled in the compression pump chamber; an injection plunger, which defines an injection pump chamber and is driven by the pressure of the fuel expelled from the compression pump chamber, a quantity of fuel determined to correspond with engine conditions being filled in the injection pump chamber; a fuel injector to which the fuel filled in the injection pump chamber is supplied in accordance with an operation of the injection plunger, and which is opened by the pressure of the fuel to inject the quantity-controlled fuel; a timing passage which communicates with the compression pump chamber and is closed when compression plunger is driven; a delta port which communicates with the compression plunger is driven; a delta port which communicates with the compression pump chamber, the delta port being closed by the compression plunger after the timing passage is closed, when the compression plunger is driven, so that an increase of fuel pressure in the compression pump chamber is delayed until after fuel is discharged from the compression pump chamber and the timing passage is closed.

  2. FPGA-Based Multiprocessor System for Injection Molding Control

    PubMed Central

    Muñoz-Barron, Benigno; Morales-Velazquez, Luis; Romero-Troncoso, Rene J.; Rodriguez-Donate, Carlos; Trejo-Hernandez, Miguel; Benitez-Rangel, Juan P.; Osornio-Rios, Roque A.

    2012-01-01

    The plastic industry is a very important manufacturing sector and injection molding is a widely used forming method in that industry. The contribution of this work is the development of a strategy to retrofit control of an injection molding machine based on an embedded system microprocessors sensor network on a field programmable gate array (FPGA) device. Six types of embedded processors are included in the system: a smart-sensor processor, a micro fuzzy logic controller, a programmable logic controller, a system manager, an IO processor and a communication processor. Temperature, pressure and position are controlled by the proposed system and experimentation results show its feasibility and robustness. As validation of the present work, a particular sample was successfully injected. PMID:23202036

  3. FPGA-based multiprocessor system for injection molding control.

    PubMed

    Muñoz-Barron, Benigno; Morales-Velazquez, Luis; Romero-Troncoso, Rene J; Rodriguez-Donate, Carlos; Trejo-Hernandez, Miguel; Benitez-Rangel, Juan P; Osornio-Rios, Roque A

    2012-10-18

    The plastic industry is a very important manufacturing sector and injection molding is a widely used forming method in that industry. The contribution of this work is the development of a strategy to retrofit control of an injection molding machine based on an embedded system microprocessors sensor network on a field programmable gate array (FPGA) device. Six types of embedded processors are included in the system: a smart-sensor processor, a micro fuzzy logic controller, a programmable logic controller, a system manager, an IO processor and a communication processor. Temperature, pressure and position are controlled by the proposed system and experimentation results show its feasibility and robustness. As validation of the present work, a particular sample was successfully injected.

  4. A targeted controlled force injection of genetic material in vivo

    PubMed Central

    Ahlén, Gustaf; Frelin, Lars; Holmström, Fredrik; Smetham, Grant; Augustyn, Steve; Sällberg, Matti

    2016-01-01

    A general limitation in gene delivery is the cellular uptake in lager animals including humans. Several approaches have been tested including liposomes, micro-needles, in vivo electro-transfer, ballistic delivery, and needle-free delivery. All these techniques have individual limitations. One approach reproducibly delivering genetic material in muscle tissue in nonhuman primates is hydrodynamic injection, a forced injection of a volume equaling the volume of the tissue to be transfected thereby causing an increased local pressure resulting in an improved uptake of genetic material. We transferred the principle of hydrodynamic injection to a device, where a small injection volume can be delivered to a targeted tissue volume, termed in vivo intracellular injection (IVIN). The device is based on needle(s) with apertures along the needle shafts, where multiple needles can fix the tissue volume to be transfected. The apertures direct the injection from a central needle outward or inward to the centroid of a geometric arrangement thereby targeting the tissue to be transfected. With a controlled force, this results in a targeted injection with increased transfection efficiency. We here show that the IVIN technology reproducibly improved plasmid uptake and expression and the immunogenicity. The IVIN technology can be generally applied to a targeted delivery of genetic materials. PMID:27069951

  5. ELECTROKINETICS, INC. INSITU BIO REMEDIATION BY ELECTROKINETIC INJECTION EMERGING TECHNOLOGY SUMMARY

    EPA Science Inventory

    Electrokinetics, Inc. through a cooperative agreement with USEPA's NRMRL conducted a laboratory evaluation of electrokinetic transport as a means to enhance in-situ bioremediation of trichloroethene (TCE). Four critical aspects of enhancing bioremediation by electrokinetic inject...

  6. High pressure common rail injection system modeling and control.

    PubMed

    Wang, H P; Zheng, D; Tian, Y

    2016-07-01

    In this paper modeling and common-rail pressure control of high pressure common rail injection system (HPCRIS) is presented. The proposed mathematical model of high pressure common rail injection system which contains three sub-systems: high pressure pump sub-model, common rail sub-model and injector sub-model is a relative complicated nonlinear system. The mathematical model is validated by the software Matlab and a virtual detailed simulation environment. For the considered HPCRIS, an effective model free controller which is called Extended State Observer - based intelligent Proportional Integral (ESO-based iPI) controller is designed. And this proposed method is composed mainly of the referred ESO observer, and a time delay estimation based iPI controller. Finally, to demonstrate the performances of the proposed controller, the proposed ESO-based iPI controller is compared with a conventional PID controller and ADRC.

  7. NOx Sensor for Direct Injection Emission Control

    SciTech Connect

    Betteridge, William J

    2006-02-28

    The Electricore/Delphi team continues to leverage the electrochemical planar sensor technology that has produced stoichiometric planar and wide range oxygen sensors as the basis for development of a NOx sensor. Zirconia cell technology with an integrated heater will provide the foundation for the sensor structure. Proven materials and packaging technology will help to ensure a cost-effective approach to the manufacture of this sensor. The electronics technique and interface is considered to be an area where new strategies need to be employed to produce higher S/N ratios of the NOx signal with emphasis on signal stability over time for robustness and durability Both continuous mode and pulse mode control techniques are being evaluated. Packaging the electronics requires careful design and circuit partitioning so that only the necessary signal conditioning electronics are coupled directly in the wiring harness, while the remainder is situated within the ECM for durability and costs reasons. This task continues to be on hold due to the limitation that the definition of the interface electronics was unavailable until very late in the project. The sense element is based on the amperometric method utilizing integrated alumina and zirconia ceramics. Precious metal electrodes are used to form the integrated heater, the cell electrodes and leads. Inside the actual sense cell structure, it is first necessary to separate NOx from the remaining oxygen constituents of the exhaust, without reducing the NOx. Once separated, the NOx will be measured using a measurement cell. Development or test coupons have been used to facilitate material selection and refinement, cell, diffusion barrier, and chamber development. The sense element currently requires elaborate interconnections. To facilitate a robust durable connection, mechanical and metallurgical connections are under investigation. Materials and process refinements continue to play an important role in the development of the

  8. Foreign technology summary of flight crucial flight control systems

    NASA Technical Reports Server (NTRS)

    Rediess, H. A.

    1984-01-01

    A survey of foreign technology in flight crucial flight controls is being conducted to provide a data base for planning future research and technology programs. Only Free World countries were surveyed, and the primary emphasis was on Western Europe because that is where the most advanced technology resides. The survey includes major contemporary systems on operational aircraft, R&D flight programs, advanced aircraft developments, and major research and technology programs. The information was collected from open literature, personal communications, and a tour of several companies, government organizations, and research laboratories in the United Kingdom, France, and the Federal Republic of Germany. A summary of the survey results to date is presented.

  9. Magnetic control of particle injection in plasma based accelerators.

    PubMed

    Vieira, J; Martins, S F; Pathak, V B; Fonseca, R A; Mori, W B; Silva, L O

    2011-06-03

    The use of an external transverse magnetic field to trigger and to control electron self-injection in laser- and particle-beam driven wakefield accelerators is examined analytically and through full-scale particle-in-cell simulations. A magnetic field can relax the injection threshold and can be used to control main output beam features such as charge, energy, and transverse dynamics in the ion channel associated with the plasma blowout. It is shown that this mechanism could be studied using state-of-the-art magnetic fields in next generation plasma accelerator experiments.

  10. Numerical simulation of flow separation control by oscillatory fluid injection

    NASA Astrophysics Data System (ADS)

    Resendiz Rosas, Celerino

    2005-07-01

    In this work, numerical simulations of flow separation control are performed. The separation control technique studied is called "synthetic jet actuation". The developed code employs a cell centered finite volume scheme which handles viscous, steady and unsteady compressible turbulent flows. The pulsating zero mass jet flow is simulated by imposing a harmonically varying transpiration boundary condition on the airfoil's surface. Turbulence is modeled with the algebraic model of Baldwin and Lomax. The application of synthetic jet actuators is based in their ability to energize the boundary layer, thereby providing significant increase in the lift coefficient. This has been corroborated experimentally and it is corroborated numerically in this research. The performed numerical simulation investigates the flow over a NACA0015 airfoil. For this flow Re = 9 x 105 and the reduced frequency and momentum coefficient are F + = 1.1 and Cmu = 0.04 respectively. The oscillatory injection takes place at 12.27% chord from the leading edge. A maximum increase in the mean lift coefficient of 93% is predicted by the code. A discrepancy of approximately 10% is observed with corresponding experimental data from the literature. The general trend is, however, well captured. The discrepancy is attributed to the modeling of the injection boundary condition and to the turbulence model. A sensitivity analysis of the lift coefficient to different values of the oscillation parameters is performed. It is concluded that tangential injection, F+ ≈ O(1) and the utilized grid resolution around the site of injection are optimal. Streamline fields obtained for different angles of injection are analyzed. Flow separation and attachment as functions of the injection angle and of the velocity of injection can be observed. It is finally concluded that a reliable numerical tool has been developed which can be utilized as a support tool in the optimization of the synthetic jet operation and in the

  11. HANDBOOK: ASSESSING THE FATE OF DEEP-WELL-INJECTED HAZARDOUS WASTE. Summaries of Recent Research

    EPA Science Inventory

    This handbook has been developed for use as a reference tool in evaluating the suitability of disposing of specific hazardous wastes in deep injection wells. sers of the document will get a better understanding of the factors that affect 1) geochemical waste-reservoir reactions o...

  12. Flow monitoring and control system for injection wells

    DOEpatents

    Corey, J.C.

    1991-01-01

    The present invention relates to a system for monitoring and controlling the rate of fluid flow from an injection well used for in-situ remediation of contaminated groundwater. The United States Government has rights in this invention pursuant to Contract No. DE-AC09-89SR18035 between the US Department of Energy and Westinghouse Savannah River Company.

  13. Analytical study of spatiotemporal chaos control by applying local injections

    PubMed

    Gang; Jinghua; Jihua; Xiangming; Yugui; Hu

    2000-09-01

    Spatiotemporal chaos control by applying local feedback injections is investigated analytically. The influence of gradient force on the controllability is investigated. It is shown that as the gradient force of the system is larger than a critical value, local control can reach very high efficiency to drive the turbulent system of infinite size to a regular target state by using a single control signal. The complex Ginzburg-Landau equation is used as a model to confirm the above analysis, and a four-wave-mixing mode is revealed to determine the dynamical behavior of the controlled system at the onset of instability.

  14. Advanced HVDC control, Volume 1: Summary report. Final report

    SciTech Connect

    Bridenbaugh, C.J.; Clark, K.; Cutler, J.M.; D`Aquila, R.; Larsen, E.V.; Lorden, D.J.; Nozari, F.; Piwko, R.J.; Walling, R.A.

    1994-09-01

    Enhancing HVDC system response to power transmission system disturbances will increase the overall security of power system operations. This five-volume report discusses the numerous performance aspects involved in the design process when applying digital control methods to HVDC systems. This study identified basic issues important in understanding the performance limits of HVDC systems regardless of control system implementation. Special attention has been given to enhancing performance for single-pole dc faults and, the most common ac network faults, namely, single-phase ac faults. In each case, investigators studied the underlying system behavior for a wide variety of network parameters, determining the type of information needed to select and apply a control philosophy. Also addressed is control of overvoltages at the connection point of the dc converter in weak ac systems by means of nonlinear filters. Based on the understanding developed during this project, this five-volume report recommends control functions that will achieve the greatest possible benefit from the system. Volume 1 contains the Summary Report, which provides brief synopses for each of the following four volumes. Volume 2 addresses the Characterization and Mitigation of AC Overvoltages and Distortion at HVDC Terminals. Volume 3 presents Concepts of Stability and Performance Enhancement with Digital Controls for HVDC Systems. Volume 4 describes the Characterization and Enhancement of HVDC System Performance During Unbalanced AC Faults. Volume 5 details the Characterization and Enhancement of HVDC System Performance During Single-Pole DC Faults.

  15. Fuel injection control based on spill port opening timing correction

    SciTech Connect

    Ban, M.; Miyaki, M.; Hasegawa, T.; Kobayashi, F.; Kobashi, M.

    1988-08-30

    This patent describes a fuel injection control system for an internal combustion engine, comprising: (a) a fuel injection pump including: a pump chamber; a low pressure chamber; plunger means reciprocating in synchronism with rotation of the engine for introducing fuel into the pump chamber, and for feeding the fuel under pressure from the pump chamber to a cylinder of the engine, detector means for detecting a reference position of the plunger, and for generating a detection signal indicative of the reference position, and a spill port coupled to the pump chamber and in communication with the low pressure chamber, (b) solenoid valve means for opening and closing the spill port; (c) first circuit means including first and second adjusting resistors, the first circuit means being replaceably disposed on the fuel injection pump; (d) first control means for calculating a fuel injection time period according to operating conditions of the engine; (e) second control means including second circuit means comprising first and second fixed resistors, the first fixed resistor being connected to the first adjusting resistor so as to produce a first voltage signal corresponding to a ratio of a resistance value of the first adjusting resistor to a resistance value of the first fixed resistor.

  16. Flow monitoring and control system for injection wells

    DOEpatents

    Corey, John C.

    1993-01-01

    A system for monitoring and controlling the injection rate of fluid by an injection well of an in-situ remediation system for treating a contaminated groundwater plume. The well is fitted with a gated insert, substantially coaxial with the injection well. A plurality of openings, some or all of which are equipped with fluid flow sensors and gates, are spaced along the insert. The gates and sensors are connected to a surface controller. The insert may extend throughout part of, or substantially the entire length of the injection well. Alternatively, the insert may comprise one or more movable modules which can be positioned wherever desired along the well. The gates are opened part-way at the start of treatment. The sensors monitor and display the flow rate of fluid passing through each opening on a controller. As treatment continues, the gates are opened to increase flow in regions of lesser flow, and closed to decrease flow in regions of greater flow, thereby approximately equalizing the amount of fluid reaching each part of the plume.

  17. Flow monitoring and control system for injection wells

    DOEpatents

    Corey, J.C.

    1993-02-16

    A system for monitoring and controlling the injection rate of fluid by an injection well of an in-situ remediation system for treating a contaminated groundwater plume. The well is fitted with a gated insert, substantially coaxial with the injection well. A plurality of openings, some or all of which are equipped with fluid flow sensors and gates, are spaced along the insert. The gates and sensors are connected to a surface controller. The insert may extend throughout part of, or substantially the entire length of the injection well. Alternatively, the insert may comprise one or more movable modules which can be positioned wherever desired along the well. The gates are opened part-way at the start of treatment. The sensors monitor and display the flow rate of fluid passing through each opening on a controller. As treatment continues, the gates are opened to increase flow in regions of lesser flow, and closed to decrease flow in regions of greater flow, thereby approximately equalizing the amount of fluid reaching each part of the plume.

  18. Effects of Water Injection into Fractured Geothermal Reservoirs: A Summary of Experience Worldwide

    SciTech Connect

    Horne, Roland N.

    1982-06-01

    Reinjection of water into fractured geothermal reservoirs holds potential both for improvement and degradation of total energy recovery. The replacement of reservoir fluid can mean support of placement of reservoir pressures and also more efficient thermal energy recovery, but at the same time the premature invasion of reinjected water back into production wells through high permeability fractures can reduce discharge enthalpy and hence deliverability and useful energy output. Increases in reservoir pressure and maintenance of field output have been observed in operating fields, but unfortunately so too have premature thermal breakthroughs. The design of reinjection schemes, therefore, requires careful investigation into the likely effects, using field experimentation. This paper summarizes field experience with reinjection around the world, with the intention of elucidating characteristics of possible problems. The results summarized in this paper fall into three categories of interest: permeability changes dye to injection (both increases and decreases); the path followed by injected water (as indicated by tracer tests); and the thermal and hydraulic influences of injection on the reinjection well itself and on surrounding producers. [DJE-2005

  19. Future directions for arms control and nonproliferation. Conference summary

    SciTech Connect

    Not Available

    1994-07-06

    This report provides a summary of the presentations and discussions at the Spring 1994 CNSN-Wilton Park Conference. The Conference was one of a series on US-European security cooperation organized by The Center for National Security Negotiations (CNSN) of Science Applications International Corporation. These conferences bring together government and non-government experts, primarily from the United States and Europe, to discuss a range of regional and global security issues. The conferences provide an opportunity to explore, in a frank and off-the-record environment, common interests and concerns, as well as differences in approach that affect trans-Atlantic cooperation. This report is divided into the following three areas: (1) implementation of existing and pending agreements; (2) non-proliferation: prospects for trans-Atlantic cooperation; and (3) future directions in arms control.

  20. Controlled electron injection using nanoparticles in laser wakefield acceleration

    NASA Astrophysics Data System (ADS)

    Cho, Myung Hoon; Pathak, Vishwa Bandhu; Kim, Hyung Taek; Nakajima, Kazuhisa; Nam, Chang Hee; CenterRelativistic Laser Science Team

    2016-10-01

    Laser wakefield acceleration is one of compact electron acceleration schemes due to its high accelerating gradient. Despite of the great progress of several GeV electron beams with high power lasers, the electron injection to the wakefield is still a critical issue for a very low density plasma 1017 electrons/cc. In this talk a novel method to control the injection using nanoparticles is proposed. We investigate the electron injection by analyzing the interaction of electrons with the two potentials - one created by a nanoparticle and the other by the wakefield. The nanoparticle creates a localized electric potential and this nanoparticle potential just slips the present wake potential. To confirm the Hamiltonian description of the interaction, a test particle calculation is performed by controlling the bubble and the nanoparticle potentials. A multi-dimensional particle-in-cell simulations are also presented as a proof-of-principle. Comparing theoretical estimates and PIC simulation, we suggest nanoparticle parameters of size and electron density depending on the background plasma density. Our scheme can be applicable for low plasma density to break though the limitation of self-injection toward extremely high energy electron energy.

  1. FURNACE INJECTION OF ALKALINE SORBENTS FOR SULFURIC ACID CONTROL

    SciTech Connect

    Gary M. Blythe

    2001-11-06

    This document summarizes progress on Cooperative Agreement DE-FC26-99FT40718, Furnace Injection of Alkaline Sorbents for Sulfuric Acid Control, during the time period April 1, 2001 through September 30, 2001. The objective of this project is to demonstrate the use of alkaline reagents injected into the furnace of coal-fired boilers as a means of controlling sulfuric acid emissions. The coincident removal of hydrochloric acid and hydrofluoric acid is also being determined, as is the removal of arsenic, a known poison for NO{sub x} selective catalytic reduction (SCR) catalysts. EPRI, the Tennessee Valley Authority (TVA), FirstEnergy Corporation, and the Dravo Lime Company are project co-funders. URS Corporation is the prime contractor. During the current period, American Electric Power (AEP) joined the project as an additional co-funder and as a provider of a host site for testing. This is the fourth reporting period for the subject Cooperative Agreement. During this period, two long-term sorbent injection tests were conducted, one on Unit 3 at FirstEnergy's Bruce Mansfield Plant (BMP) and one on Unit 1 at AEP's Gavin Station. These tests determined the effectiveness of injecting alkaline slurries into the upper furnace of the boiler as a means of controlling sulfuric acid emissions from these units. The alkaline slurries tested included commercially available magnesium hydroxide slurry (Gavin Station), and a byproduct magnesium hydroxide slurry (both Gavin Station and BMP). The tests showed that injecting either the commercial or the byproduct magnesium hydroxide slurry could achieve up to 70 to 75% sulfuric acid removal. At BMP, the overall removal was limited by the need to maintain acceptable electrostatic precipitator (ESP) particulate control performance. At Gavin Station, the overall sulfuric acid removal was limited because the furnace injected sorbent was less effective at removing SO{sub 3} formed across the SCR system installed on the unit for NO{sub x

  2. Beam diagnostics, collimation, injection/extraction, targetry, accidents and commissioning: Working group C&G summary report

    SciTech Connect

    Mokhov, N.V.; Hasegawa, K.; Henderson, S.; Schmidt, R.; Tomizawa, M.; Wittenburg, K.; /DESY

    2006-11-01

    The performance of accelerators with high beam power or high stored beam energy is strongly dependent on the way the beam is handled, how beam parameters are measured and how the machine is commissioned. Two corresponding working groups have been organized for the Workshop: group C ''Beam diagnostics, collimation, injection/extraction and targetry'' and group G ''Commissioning strategies and procedures''. It has been realized that the issues to be discussed in these groups are interlaced with the participants involved and interested in the above topics, with an extremely important subject of beam-induced accidents as additional topic. Therefore, we have decided to combine the group sessions as well as this summary report. Status, performance and outstanding issues of each the topic are described in the sections below, with additional observations and proposals by the joint group at the end.

  3. Control System of Neutral Beam Injection on HT-7

    NASA Astrophysics Data System (ADS)

    Wang, Yongjun; Hu, Chundong; Liu, Zhimin; Liu, Sheng; Song, Shihua; Yang, Daoye

    2005-06-01

    Neutral Beam Injection control system (NBICS) is constructed to measure the plasma current, Magnet current, vacuum pressure, cryopump temperature, control water cooling, filament voltage, and power supply, etc. The NBICS, consisting mainly of a Programmable Logic Controller (PLC) subsystem, data acquisition and processing subsystem and cryopump and vacuum pressure monitoring subsystem, has successfully been used on a NBI device. In this article, the design of NBICS on HT-7 is discussed and each subsystem is described in particular. In addition, some experimental results are reported which are very important data for further research related to the HT-7 tokamak.

  4. Control over Drug Acquisition, Preparation, and Injection: Implications for HIV and HCV Risk among Young Female Injection Drug Users

    PubMed Central

    Wagner, Karla D.; Jackson Bloom, Jennifer; Hathazi, Susan Dodi; Sanders, Bill; Lankenau, Stephen E.

    2013-01-01

    Young female injection drug users (IDUs) are at risk for HIV/HCV, and initiating the use of a new drug may confer additional and unexpected risks. While gender differences in the social context of injection drug use have been identified, it is unknown whether those differences persist during the initiation of a new drug. This mixed-methods study examined the accounts of 30 young female IDUs in Los Angeles, CA, USA from 2004 to 2006, who described the social context of initiating injection drug use and initiating ketamine injection. The analysis aimed to understand how the social context of young women's injection events contributes to HIV/HCV risk. Women's initiation into ketamine injection occurred approximately 2 years after their first injection of any drug. Over that time, women experienced changes in some aspects of the social context of drug injection, including the size and composition of the using group. A significant proportion of women described injection events characterized by a lack of control over the acquisition, preparation, and injection of drugs, as well as reliance on friends and sexual partners. Findings suggest that lack of control over drug acquisition, preparation, and injection may elevate women's risk; these phenomena should be considered as a behavioral risk factor when designing interventions. PMID:24364027

  5. FURNACE INJECTION OF ALKALINE SORBENTS FOR SULFURIC ACID CONTROL

    SciTech Connect

    Gary M. Blythe

    2000-12-01

    A test program is being sponsored by the US Department of Energy (DOE), EPRI, FirstEnergy, and TVA to investigate furnace injection of alkaline sorbents as a means of reducing sulfuric acid concentrations in the flue gas from coal-fired boilers. This test program is being conducted at the FirstEnergy Bruce Mansfield Plant (BMP), although later testing will be conducted at a TVA plant. A sorbent injection test was conducted the week of April 18, 2000. The test was the first of several short-term (one- to two-week duration) tests to investigate the effectiveness of various alkaline sorbents for sulfuric acid control and the effects of these sorbents on boiler equipment performance. This first short-term test investigated the effect of injecting dry dolomite powder (CaCO{sub 3} {center_dot} MgCO{sub 3}), a mineral similar to limestone, into the furnace of Unit 2. During the test program, various analytical techniques were used to assess the effects of sorbent injection. These primarily included sampling with the controlled condensation system (CCS) for determining flue gas SO{sub 3} content and an acid dew-point (ADP) meter for determining the sulfuric acid dew point (and, indirectly, the concentration of sulfuric acid) of the flue gas. EPA Reference Method 26a was used for determining hydrochloric acid (HCl) and hydrofluoric acid (HF), as well and chlorine (Cl{sub 2}) and fluorine (F{sub 2}) concentrations in the flue gas. Fly ash resistivity was measured using a Southern Research Institute (SRI) point-to-plane resistivity probe, and unburned carbon in fly ash was determined by loss on ignition (LOI). Coal samples were also collected and analyzed for a variety of parameters. Finally, visual observations were made of boiler furnace and convective pass surfaces prior to and during sorbent injection.

  6. Summary

    SciTech Connect

    Powell, Danny H; Elwood Jr, Robert H

    2011-01-01

    An effective risk assessment system is needed to address the threat posed by an active or passive insider who, acting alone or in collusion, could attempt diversion or theft of nuclear material. The material control and accountability (MC&A) system effectiveness tool (MSET) is a self-assessment or inspection tool utilizing probabilistic risk assessment (PRA) methodology to calculate the system effectiveness of a nuclear facility's material protection, control, and accountability (MPC&A) system. The MSET process is divided into four distinct and separate parts: (1) Completion of the questionnaire that assembles information about the operations of every aspect of the MPC&A system; (2) Conversion of questionnaire data into numeric values associated with risk; (3) Analysis of the numeric data utilizing the MPC&A fault tree and the SAPHIRE computer software; and (4) Self-assessment using the MSET reports to perform the effectiveness evaluation of the facility's MPC&A system. The process should lead to confirmation that mitigating features of the system effectively minimize the threat, or it could lead to the conclusion that system improvements or upgrades are necessary to achieve acceptable protection against the threat. If the need for system improvements or upgrades is indicated when the system is analyzed, MSET provides the capability to evaluate potential or actual system improvements or upgrades. A facility's MC&A system can be evaluated at a point in time. The system can be reevaluated after upgrades are implemented or after other system changes occur. The total system or specific subareas within the system can be evaluated. Areas of potential system improvement can be assessed to determine where the most beneficial and cost-effective improvements should be made. Analyses of risk importance factors show that sustainability is essential for optimal performance and reveals where performance degradation has the greatest impact on total system risk. The risk

  7. The Role of Vorticity Injection in Separation Control

    NASA Astrophysics Data System (ADS)

    Taira, Kunihiko; Munday, Phillip

    2013-11-01

    Large eddy simulation is performed to examine the role of vorticity injection in separation control of spanwise periodic flow over a NACA0012 airfoil. The computations are conducted with a high-fidelity LES solver CharLES with sufficient grid resolution to resolve the near-wall turbulence at a moderate Reynolds number of Re = 23 , 000 . The actuator input is introduced to the flow field through the velocity boundary condition to specify the desired vorticity flux input. The aim of this investigation is to analyze the influence of the injected vorticity magnitude and direction on the separation physics over the airfoil such that the separation is delayed. The vortical perturbation is added to break apart the large spanwise vortices responsible for causing separation and hence delay stall. The range of the vorticity injected is chosen to match those from commonly used flow control devices for separation control. In this study, particular focus is placed on examining the interaction between the actuator input and the inherent Kelvin-Helmholtz and spanwise instabilities. Work supported by AFOSR (Award No. FA9550-13-1-0183).

  8. FURNACE INJECTION OF ALKALINE SORBENTS FOR SULFURIC ACID CONTROL

    SciTech Connect

    Gary M. Blythe

    2003-10-01

    This document summarizes progress on Cooperative Agreement DE-FC26-99FT40718, Furnace Injection of Alkaline Sorbents for Sulfuric Acid Control, during the time period April 1, 2003 through September, 2003. The objective of this project is to demonstrate the use of alkaline reagents injected into the furnace of coal-fired boilers as a means of controlling sulfuric acid emissions. The coincident removal of hydrochloric acid and hydrofluoric acid is also being determined, as is the removal of arsenic, a known poison for NO{sub x} selective catalytic reduction (SCR) catalysts. EPRI, the Tennessee Valley Authority (TVA), FirstEnergy Corporation, American Electric Power (AEP) and the Dravo Lime Company are project co-funders. URS Group is the prime contractor. This is the eighth reporting period for the subject Cooperative Agreement. During previous reporting periods, two long-term sorbent injection tests were conducted, one on Unit 3 at FirstEnergy's Bruce Mansfield Plant (BMP) and one on Unit 1 at AEP's Gavin Plant. Those tests determined the effectiveness of injecting alkaline slurries into the upper furnace of the boiler as a means of controlling sulfuric acid emissions from these units. The alkaline slurries tested included commercially available magnesium hydroxide slurry (Gavin Plant), and a byproduct magnesium hydroxide slurry (both Gavin Plant and BMP). The tests showed that injecting either the commercial or the byproduct magnesium hydroxide slurry could achieve up to 70-75% overall sulfuric acid removal. At BMP, the overall removal was limited by the need to maintain acceptable electrostatic precipitator (ESP) particulate control performance. At Gavin Plant, the overall sulfuric acid removal was limited because the furnace injected sorbent was less effective at removing SO{sub 3} formed across the SCR system installed on the unit for NO{sub x} control than at removing SO{sub 3} formed in the furnace. The SO{sub 3} removal results were presented in the semi

  9. FURNACE INJECTION OF ALKALINE SORBENTS FOR SULFURIC ACID CONTROL

    SciTech Connect

    Gary M. Blythe

    2003-06-01

    This document summarizes progress on Cooperative Agreement DE-FC26-99FT40718, Furnace Injection of Alkaline Sorbents for Sulfuric Acid Control, during the time period October 1, 2002 through March 31, 2003. The objective of this project is to demonstrate the use of alkaline reagents injected into the furnace of coal-fired boilers as a means of controlling sulfuric acid emissions. The coincident removal of hydrochloric acid and hydrofluoric acid is also being determined, as is the removal of arsenic, a known poison for NO{sub x} selective catalytic reduction (SCR) catalysts. EPRI, the Tennessee Valley Authority (TVA), FirstEnergy Corporation, American Electric Power (AEP) and the Dravo Lime Company are project co-funders. URS Group is the prime contractor. This is the seventh reporting period for the subject Cooperative Agreement. During previous reporting periods, two long-term sorbent injection tests were conducted, one on Unit 3 at FirstEnergy's Bruce Mansfield Plant (BMP) and one on Unit 1 at AEP's Gavin Plant. Those tests determined the effectiveness of injecting alkaline slurries into the upper furnace of the boiler as a means of controlling sulfuric acid emissions from these units. The alkaline slurries tested included commercially available magnesium hydroxide slurry (Gavin Plant), and a byproduct magnesium hydroxide slurry (both Gavin Plant and BMP). The tests showed that injecting either the commercial or the byproduct magnesium hydroxide slurry could achieve up to 70-75% overall sulfuric acid removal. At BMP, the overall removal was limited by the need to maintain acceptable electrostatic precipitator (ESP) particulate control performance. At Gavin Plant, the overall sulfuric acid removal was limited because the furnace injected sorbent was less effective at removing SO{sub 3} formed across the SCR system installed on the unit for NO{sub x} control than at removing SO{sub 3} formed in the furnace. The SO3 removal results were presented in the semi

  10. Piezo stack actuation control system for sperm injection

    NASA Astrophysics Data System (ADS)

    Tan, K. K.; Putra, A. S.

    2005-12-01

    Among the electric motor drives, the piezoelectric actuator (PA) is one drive which is becoming very popular in high precision biomedical applications, such as intracytoplasmic sperm injection. The main benefits of a PA include low thermal losses and, most importantly, the high precision and accuracy achievable consequent of the driect drive principle. One major source of uncertainties in PA control design is the hysteresis behavior which yields a rate-independent lag and residual displacement near zero input, reducing the precision of the actuators. Due to the typical precision positioning requirements and low offset tolerance of PA applications, the design and control of these systems, under the influence of these uncertainties, is particularly challenging since conventional PID control usually does not suffice in these application domains to meet the stringent performance requirements. In this paper, we consider the design and realization of a piezo stack actuator which is capable of linear motion and non-full rotation to fulfill the stringent requirements associated with sperm injection applications. A complementary precise control system is developed employing a robust adaptive control algorithm to reject the hysteresis phenomenon associated with general PAs and to achieve rapid and highly precise positioning. The controller comprises of a PID feedback component and an adaptive component for hysteresis compensation. The adaptive component is continuously refined based on just prevailing input and output signals. In the paper, it will be proven that the tracking error can asymptotically converge to zero. In addition, analytical quantification is given to illustrate the improvement of the system's transient performance. Real-time experimental results verify the effectiveness of the proposed micro actuator for high precision motion trajectory tracking in intracytoplasmic sperm injection using mice eggs.

  11. Radium Ra 223 dichloride injection: U.S. Food and Drug Administration drug approval summary.

    PubMed

    Kluetz, Paul G; Pierce, William; Maher, V Ellen; Zhang, Hui; Tang, Shenghui; Song, Pengfei; Liu, Qi; Haber, Martin T; Leutzinger, Eldon E; Al-Hakim, Ali; Chen, Wei; Palmby, Todd; Alebachew, Elleni; Sridhara, Rajeshwari; Ibrahim, Amna; Justice, Robert; Pazdur, Richard

    2014-01-01

    On May 15, 2013, the U.S. Food and Drug Administration (FDA) approved radium Ra 223 dichloride (Ra-223; Xofigo injection; Bayer HealthCare Pharmaceuticals Inc.) for the treatment of patients with castration-resistant prostate cancer (CRPC), symptomatic bone metastases, and no known visceral metastatic disease. The FDA review was based on clinical trial BC1-06, which randomly allocated patients (2:1) to either Ra-223 plus best standard of care (BSoC) or placebo plus BSoC. The primary endpoint was overall survival (OS) with a key secondary endpoint of time to first symptomatic skeletal event (SSE). A statistically significant improvement in OS was demonstrated [HR, 0.70; 95% confidence interval, 0.55-0.88, P = 0.0019]. At the prespecified interim analysis, the median OS durations were 14.0 and 11.2 months in the Ra-223 and placebo arms, respectively. The improvement in OS was supported by a delay in time to first SSE favoring the Ra-223 arm. The most common (>10%) adverse reactions in patients receiving Ra-223 were nausea, diarrhea, vomiting, and peripheral edema. The most common (>10%) hematologic laboratory abnormalities were anemia, lymphocytopenia, leukopenia, thrombocytopenia, and neutropenia. Ra-223 is the first α-emitting radiotherapeutic and the first radiopharmaceutical to demonstrate an OS advantage in metastatic prostate cancer.

  12. Apparatus and method for controlling the secondary injection of fuel

    DOEpatents

    Martin, Scott M.; Cai, Weidong; Harris, Jr., Arthur J.

    2013-03-05

    A combustor (28) for a gas turbine engine is provided comprising a primary combustion chamber (30) for combusting a first fuel to form a combustion flow stream (50) and a transition piece (32) located downstream from the primary combustion chamber (30). The transition piece (32) comprises a plurality of injectors (66) located around a circumference of the transition piece (32) for injecting a second fuel into the combustion flow stream (50). The injectors (66) are effective to create a radial temperature profile (74) at an exit (58) of the transition piece (32) having a reduced coefficient of variation relative to a radial temperature profile (64) at an inlet (54) of the transition piece (32). Methods for controlling the temperature profile of a secondary injection are also provided.

  13. In Situ Decommissioning Sensor Network, Meso-Scale Test Bed - Phase 3 Fluid Injection Test Summary Report

    SciTech Connect

    Serrato, M. G.

    2013-09-27

    located at the Florida International University Applied Research Center, Miami, FL (FIU-ARC). A follow-on fluid injection test was developed to detect fluid and ion migration in a cementitious material/grouted test cube using a limited number of existing embedded sensor systems. This In Situ Decommissioning Sensor Network, Meso-Scale Test Bed (ISDSN-MSTB) - Phase 3 Fluid Injection Test Summary Report summarizes the test implementation, acquired and processed data, and results from the activated embedded sensor systems used during the fluid injection test. The ISDSN-MSTB Phase 3 Fluid Injection Test was conducted from August 27 through September 6, 2013 at the FIU-ARC ISDSN-MSTB test cube. The fluid injection test activated a portion of the existing embedded sensor systems in the ISDSN-MSTB test cube: Electrical Resistivity Tomography-Thermocouple Sensor Arrays, Advance Tensiometer Sensors, and Fiber Loop Ringdown Optical Sensors. These embedded sensor systems were activated 15 months after initial placement. All sensor systems were remotely operated and data acquisition was completed through the established Sensor Remote Access System (SRAS) hosted on the DOE D&D Knowledge Management Information Tool (D&D DKM-IT) server. The ISDN Phase 3 Fluid Injection Test successfully demonstrated the feasibility of embedding sensor systems to assess moisture-fluid flow and resulting transport potential for contaminate mobility through a cementitious material/grout monolith. The ISDSN embedded sensor systems activated for the fluid injection test highlighted the robustness of the sensor systems and the importance of configuring systems in-depth (i.e., complementary sensors and measurements) to alleviate data acquisition gaps.

  14. Utility flue gas mercury control via sorbent injection

    SciTech Connect

    Chang, R.; Carey, T.; Hargrove, B.

    1996-12-31

    The potential for power plant mercury control under Title III of the 1990 Clean Air Act Amendments generated significant interest in assessing whether cost effective technologies are available for removing the mercury present in fossil-fired power plant flue gas. One promising approach is the direct injection of mercury sorbents such as activated carbon into flue gas. This approach has been shown to be effective for mercury control from municipal waste incinerators. However, tests conducted to date on utility fossil-fired boilers show that it is much more difficult to remove the trace species of mercury present in flue gas. EPRI is conducting research in sorbent mercury control including bench-scale evaluation of mercury sorbent activity and capacity with simulated flue gas, pilot testing under actual flue gas conditions, evaluation of sorbent regeneration and recycle options, and the development of novel sorbents. A theoretical model that predicts maximum mercury removals achievable with sorbent injection under different operating conditions is also being developed. This paper presents initial bench-scale and model results. The results to date show that very fine and large amounts of sorbents are needed for mercury control unless long residence times are available for sorbent-mercury contact. Also, sorbent activity and capacity are highly dependent on flue gas composition, temperature, mercury species, and sorbent properties. 10 refs., 4 figs., 2 tabs.

  15. 77 FR 26755 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... Exemption--Class I Hazardous Waste Injection; Diamond Shamrock Refining Company, LP, Sunray, TX AGENCY... granted to Diamond Shamrock for three Class I injection wells located at Sunray, Texas. The company has... final decision allows the continued underground injection by Diamond Shamrock, of the...

  16. Injection pump with radially mounted spill control valve

    SciTech Connect

    Djordjevic, I.

    1987-05-26

    This patent describes a rotary fuel injection pump for an internal combustion engine,. The method comprises: a housing, a rotor rotatable in the housing, a charge pump having radially extending plunger bores in the rotor and a plunger pump for each plunger bore having a pumping plunger reciprocable in the bore. The pumping plunger has outward fuel tank strokes and inward fuel delivery strokes for supplying high pressure charges of fuel for fuel injection. A cam ring surrounds the rotor and is engageable with the plunger pumps to reciprocate the plungers as the rotor rotates. A spill control mechanism has spill valve means connected to the charge pump for spill control of the high pressure charge of fuel. The improvement consists of the spill valve means which comprises at least one rotary spill valve having a valve bore in the rotor oriented transversely to the axis of the rotor and connected to the charge pump through pump passage means and a rotary spill valve member rotatably mounted within the valve bore; and the spill control mechanism.

  17. 78 FR 48639 - North Dakota Underground Injection Control Program Revision Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... AGENCY 40 CFR Part 147 North Dakota Underground Injection Control Program Revision Application AGENCY... Injection Control (UIC) program to include Class VI primacy; that the EPA has determined the application... Underground Injection Control Program Revision Application to add Class VI wells to its Sec. 1422...

  18. Enhanced controllability of domain-wall pinning by asymmetric control of domain-wall injection.

    PubMed

    Ahn, Sung-Min; Moon, Kyoung-Woong

    2013-03-15

    We investigate a control scheme for enhancing the controllability of domain-wall (DW) pinning on ferromagnetic devices using an interaction between magnetic charges distributed on a nanobar and at a notch, respectively. The scheme is realized at an artificial notch with a nanobar vertical to it on Permalloy nanowires with an asymmetrical pad. Injection fields for injecting the DWs from the asymmetrical pad to the nanowire show an asymmetrical dependence on the saturation angle for initializing the magnetization of the nanowire, and the injected DWs are pinned by the notch with the nanobar vertical to it. We have found that the landscape of the pinning potential energy experienced by the DWs depends on the magnetized direction of the nanobar and that its level is shifted by the injection field, leading to an increase or decrease in the depinning field with respect to the saturation angle. This is consistent with our estimation based on micromagnetic simulation.

  19. Rapid control of mold temperature during injection molding process

    SciTech Connect

    Liparoti, Sara; Titomanlio, Giuseppe; Hunag, Tsang Min; Cakmak, Mukerrem; Sorrentino, Andrea

    2015-05-22

    The control of mold surface temperature is an important factor that determines surface morphology and its dimension in thickness direction. It can also affect the frozen molecular orientation and the mold surface replicability in injection molded products. In this work, thin thermally active films were used to quickly control the mold surface temperature. In particular, an active high electrical conductivity carbon black loaded polyimide composites sandwiched between two insulating thin polymeric layers was used to condition the mold surface. By controlling the heating time, it was possible to control precisely the temporal variation of the mold temperature surface during the entire cycle. The surface heating rate was about 40°C/s and upon contact with the polymer the surface temperature decreased back to 40°C within about 5 s; the overall cycle time increased only slightly. The effect on cross section sample morphology of samples of iPP were analyzed and discussed on the basis of the recorded temperature evolution.

  20. Embedded computer controlled premixing inline injection system for air-assisted variable-rate sprayers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Improvements to reduce chemical waste and environmental pollution for variable-rate sprayers used in orchards and ornamental nurseries require inline injection techniques. A microprocessor controlled premixing inline injection system implementing a ceramic piston chemical metering pump and two small...

  1. 78 FR 76294 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ... Exemption--Class I Hazardous Waste Injection; Mosaic Fertilizer, LLC Uncle Sam, LA AGENCY: Environmental... Waste Amendments to the Resource Conservation and Recovery Act, has been granted to Mosaic...

  2. Screening of conditions controlling spectrophotometric sequential injection analysis

    PubMed Central

    2011-01-01

    Background Despite its potential benefits over univariate, chemometrics is rarely utilized for optimizing sequential injection analysis (SIA) methods. Specifically, in previous vis-spectrophotometric SIA methods, chemometrically optimized conditions were confined within flow rate and reagent concentrations while other conditions were ignored. Results The current manuscript reports, for the first time, a comprehensive screening of conditions controlling vis-spectrophotometric SIA. A new diclofenac assay method was adopted. The method was based on oxidizing diclofenac by permanganate (a major reagent) with sulfuric acid (a minor reagent). The reaction produced a spectrophotometrically detectable diclofenac form. The 26 full-factorial design was utilized to study the effect of volumes of reagents and sample, in addition to flow rate and concentrations of reagents. The main effects and all interaction order effects on method performance, i.e. namely sensitivity, rapidity and reagent consumption, were determined. The method was validated and applied to pharmaceutical formulations (tablets, injection and gel). Conclusions Despite 64 experiments those conducted in the current study were cumbersome, the results obtained would reduce effort and time when developing similar SIA methods in the future. It is recommended to critically optimize effective and interacting conditions using other such optimization tools as fractional-factorial design, response surface and simplex, rather than full-factorial design that used at an initial optimization stage. In vis-spectrophotometric SIA methods those involve developing reactions with two reagents (major and minor), conditions affecting method performance are in the following order: sample volume > flow rate ≈ major reagent concentration >> major reagent volume ≈ minor reagent concentration >> minor reagent volume. PMID:21333024

  3. Control of Pseudo-Shock by Slot Injection

    NASA Astrophysics Data System (ADS)

    Okui, Hidetaka; Hiraki, Hisashi; Park, Myeong-Kwan; Oshima, Shuzo; Yamane, Ryuichiro

    It is well known that the boundary layer separation due to the adverse pressure gradient of the pseudo-shock affects the dynamic feature of the pseudo-shock such as the shape of the first shock, the pressure recovery and the self-induced oscillation. The suppression of the separation is effective to control the interaction between the shock wave and the boundary layer. In this research, the boundary layer control with the slot injection is studied experimentally and numerically. The experiment is carried out in a blow-down supersonic wind tunnel at free stream Mach number of 2.0. The numerical simulation is made with the two-dimensional compressible Navier-Stokes code. In solving the equations, the second-order accurate Harten-Yee's upwind TVD scheme and k-ɛ turbulence model modified for the compressible flow are used. The results show that the separation is appreciably suppressed and the shape of the first shock is changed, resulting the wall pressure fluctuation to be greatly reduced. Furthermore the total pressure loss is decreased with the low slot height.

  4. Development of ADOCS controllers and control laws. Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    Landis, Kenneth H.; Glusman, Steven I.

    1985-01-01

    The Advanced Cockpit Controls/Advanced Flight Control System (ACC/AFCS) study was conducted by the Boeing Vertol Company as part of the Army's Advanced Digital/Optical Control System (ADOCS) program. Specifically, the ACC/AFCS investigation was aimed at developing the flight control laws for the ADOCS demonstrator aircraft that will provide satisfactory handling qualities for an attack helicopter mission. The three major elements of design considered during the study are as follows: Pilot's integrated Side-Stick Controller (SSC) -- Number of axes controlled; force/displacement characteristics; ergonomic design. Stability and Control Augmentation System (SCAS)--Digital flight control laws for the various mission phases; SCAS mode switching logic. Pilot's Displays--For night/adverse weather conditions, the dynamics of the superimposed symbology presented to the pilot in a format similar to the Advanced Attack Helicopter (AAH) Pilot Night Vision System (PNVS) for each mission phase as a function of SCAS characteristics; display mode switching logic. Volume 1 is an Executive Summary of the study. Conclusions drawn from analysis of pilot rating data and commentary were used to formulate recommendations for the ADOCS demonstrator flight control system design. The ACC/AFCS simulation data also provide an extensive data base to aid the development of advanced flight control system design for future V/STOL aircraft.

  5. Distributor-type fuel injection pump having injection rate control function for internal combustion engines

    SciTech Connect

    Taira, S.; Ishibashi, T.

    1987-04-07

    This patent describes a distributor-type fuel injection pump for an internal combustion engine having a plurality of cylinders and a plurality of fuel injection valves for injecting fuel into respective ones of the cylinders. The fuel injection pump includes a plunger arranged for concurrent reciprocating and rotative motion in response to rotation of the engine to perform pressure delivery and distribution of fuel into the cylinders of the engine. The plunger has a first portion and a second portion having different diameters from each other, a first pump working chamber defined by the first portion, and a second pump working chamber defined by the second portion. Fuel delivery passageways are arranged for communication with the first pump working chamber and lead to respective ones of the fuel injection valves of the engine. A communication passageway is arranged for communicating the second pump working chamber with the fuel delivery passageways and a drain passageway is arranged for communicating the communication passageway with a zone under a lower pressure of the pump.

  6. Impact on Caesarean section rates following injections of sterile water (ICARIS): a multicentre randomised controlled trial

    PubMed Central

    2013-01-01

    Background Sterile water injections have been used as an effective intervention for the management of back pain during labour. The objective of the current research is to determine if sterile water injections, as an intervention for back pain in labour, will reduce the intrapartum caesarean section rate. Methods/design Design: A double blind randomised placebo controlled trial Setting: Maternity hospitals in Australia Participants: 1866 women in labour, ≥18 years of age who have a singleton pregnancy with a fetus in a cephalic presentation at term (between 37 + 0 and 41 + 6 weeks gestation), who assess their back pain as equal to or greater than seven on a visual analogue scale when requesting analgesia and able to provide informed consent. Intervention: Participants will be randomised to receive either 0.1 to 0.3 millilitres of sterile water or a normal saline placebo via four intradermal injections into four anatomical points surrounding the Michaelis’ rhomboid over the sacral area. Two injections will be administered over the posterior superior iliac spine (PSIS) and the remaining two at two centimetres posterior, and one centimetre medial to the PSIS respectively. Main outcome measure:Proportion of women who have a caesarean section in labour. Randomisation: Permuted blocks stratified by research site. Blinding (masking):Double-blind trial in which participants, clinicians and research staff blinded to group assignment. Funding:Funded by the National Health and Medical Research Council Trial registration:Australian New Zealand Clinical Trials Registry (No ACTRN12611000221954). Discussion Sterile water injections, which may have a positive effect on reducing the CS rate, have been shown to be a safe and simple analgesic suitable for most maternity settings. A procedure that could reduce intervention rates without adversely affecting safety for mother and baby would benefit Australian families and taxpayers and would reduce requirements for maternal operating

  7. Overview of underground injection control regulations relating to Class II (oil and gas associated) injection wells - past, present, and future

    SciTech Connect

    Syed, T.

    1989-04-01

    The Safe Drinking Water Act of 1974 mandates US Environmental Protection Agency (USEPA) and primacy state regulation of injection wells in order to protect underground sources of drinking water (USDW) from contamination. Currently five classes (I-V) of injection wells exist with class II wells being those used in conjunction with oil and gas production activities. In 1986, 60 million bbl of oil-field fluids were injected through 166,000 injection wells in the continental US. These disposal volumes will increase significantly in the future as the producing fields continue to be depleted. The petroleum industry's generally good track record in protecting the nation's ground-water resources, unfortunately, has not been accepted by all sectors of the public. This in turn, has led to the current reevaluation of the existing class II regulatory framework and a reassessment of the degree of protection afforded to USDW from oil and gas activities. This presentation gives an overview of the evolution, current status, and emerging trends in class II Underground Injection Control regulations. Key areas discussed include well construction, operating and monitoring requirements, mechanical integrity testing, plugging and abandonment procedures, and financial assurance demonstrations. The petroleum industry must continue to work closely with EPA and other regulatory agencies in identifying and correcting any deficiencies in current injection practices. A sincere and open approach by both parties will prevent unnecessary additional regulatory burdens and enhance the petroleum industry's image and its commitment to continued protection of the drinking water resources.

  8. Electron ripple injection concept for tokamak transport control

    NASA Astrophysics Data System (ADS)

    Choe, W.; Ono, M.; Chang, C. S.

    1996-02-01

    A non-intrusive method for inducing a radial electric field (Er) based on electron ripple injection (ERI) is under development by the Princeton CDX-U group. Since Er is known to play an important role in the L-H and H-VH mode transition, it is therefore important to develop a non-intrusive tool to control the Er profile in tokamak plasmas. The present technique utilizes externally-applied local magnetic ripple fields to trap electrons at the edge, allowing them to penetrate towards the plasma center via ∇B and curvature drifts, causing the flux surfaces to charge up negatively. Electron cyclotron resonance heating (ECRH) is utilized to increase the trapped population and the electron drift velocity by raising the perpendicular energy of trapped electrons. The temperature anisotropy of resonant electrons in a tokamak plasma is calculated in order to investigate effects of ECRH on electrons. Simulations using a guiding-center orbit model have been performed to understand the behavior of suprathermal electrons in the presence of ripple fields. Examples for CDX-U and ITER are given.

  9. Summary of electric vehicle dc motor-controller tests

    NASA Technical Reports Server (NTRS)

    Mcbrien, E. F.; Tryon, H. B.

    1982-01-01

    The differences in the performance of dc motors are evaluated when operating with chopper type controllers, and when operating on direct current. The interactions between the motor and the controller which cause these differences are investigated. Motor-controlled tests provided some of the data the quantified motor efficiency variations for both ripple free and chopper modes of operation.

  10. SUMMARY REPORT CONTROL OF NOX EMISSIONS BY REBURNING

    EPA Science Inventory

    This report covers NOx control employing reburning technology: A new, effective method of controlling NOx emissions from a wide range of stationary combustion sources including large, coal-fired, utility boilers. Although reburning potentially is applicable ...

  11. Control Systems Security Test Center - FY 2004 Program Summary

    SciTech Connect

    Robert E. Polk; Alen M. Snyder

    2005-04-01

    In May 2004, the US-CERT Control Systems Security Center (CSSC) was established at Idaho National Laboratory to execute assessment activities to reduce the vulnerability of the nation’s critical infrastructure control systems to terrorist attack. The CSSC implements a program to accomplish the five goals presented in the US-CERT National Strategy for Control Systems Security. This report summarizes the first year funding of startup activities and program achievements that took place in FY 2004 and early FY 2005. This document was prepared for the US-CERT Control Systems Security Center of the National Cyber Security Division of the Department of Homeland Security (DHS). DHS has been tasked under the Homeland Security Act of 2002 to coordinate the overall national effort to enhance the protection of the national critical infrastructure. Homeland Security Presidential Directive HSPD-7 directs federal departments to identify and prioritize the critical infrastructure and protect it from terrorist attack. The US-CERT National Strategy for Control Systems Security was prepared by the National Cyber Security Division to address the control system security component addressed in the National Strategy to Secure Cyberspace and the National Strategy for the Physical Protection of Critical Infrastructures and Key Assets. The US-CERT National Strategy for Control Systems Security identified five high-level strategic goals for improving cyber security of control systems.

  12. Corrosion Effects of Calcium Chloride Injection for Mercury Control on the Pollution Control Equipment

    SciTech Connect

    Vijay Sethi; M.P. Sharma

    2009-02-28

    In response to the Clean Air Mercury Rule (CAMR) of 2005, Black Hills Power (BHP) initiated testing of a calcium chloride (CaCl{sub 2}) injection method in their Wygen 1 (Gillette, WY) coal-fired power plant to help lower mercury emissions. In 2006, Babcock & Wilcox (B&W) was contracted to test their CaCl{sub 2} technology in-situ by adding a CaCl{sub 2} solution onto the raw, pre-pulverized coal during normal operation of Wygen 1. Follow-up tests were conducted by BHP in 2007. Data were collected from these two time periods and analyzed by a collaborative investigation team from Western Research Institute (WRI) and the University of Wyoming (UW) to see if there were any effects on the current air pollution control systems. During a CaCl{sub 2} injection period in 2007, corrosion was monitored in the flue and recycle ash system by placing corrosion coupons in strategic locations to test if corrosion was enhanced by the CaCl{sub 2} injection. While the CaCl{sub 2} produced a reduction in stack mercury levels, there was some evidence of beneficial impacts on the removal of SO{sub 2} from the flue gas during CaCl{sub 2} injection. Data on NOx remained inconclusive. It was also discovered that corrosion was enhanced significantly in the Spray Drier Absorber (SDA) vessel and corresponding outlet ductwork during CaCl{sub 2} injections. Further studies are being carried out in the field and lab to better understand the corrosive effects of CaCl{sub 2} to help formulate operation controls to manage the increased corrosion rates.

  13. 77 FR 26231 - State of Tennessee; Underground Injection Control (UIC) Program Primacy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-03

    ... AGENCY 40 CFR Part 147 State of Tennessee; Underground Injection Control (UIC) Program Primacy AGENCY: U... application from the State of Tennessee requesting approval of its Underground Injection Control program; 2... June 7, 2012 at 1:00 p.m. Requests to testify may be mailed to Fred McManus, Chief, Ground Water...

  14. Fuel injection system electromagnetic-valve controlled type

    SciTech Connect

    Oshizawa, H.; Ishikawa, M.

    1989-01-31

    A fuel injection system for an engine is described including: (a) a fuel injection pump having a pump housing, a plunger associated with the pump housing and reciprocatively movable in relation to rotation of a crankshaft of the engine, and a fuel pressurizing chamber associated with the pump housing and variable in volume in response to reciprocative movement of the plunger; (b) supply passage means supplying fuel to the fuel pressurizing chamber, the supply passage means being closed substantially during a forward stroke of the plunger and being opened substantially during a backward stroke of the plunger; (c) forcible-delivery passage means connecting the fuel pressurizing chamber to at least one fuel injection nozzle of the engine; (d) release passage means communicating with the fuel pressurizing chamber.

  15. Boundary Layer Control in Pipes through Strong Injection

    SciTech Connect

    Yeung, William Chor-Chun; Holt, Maurice

    1982-01-01

    In coal gasification, oxidation and sulfidization cause serious pipe corrosion. This study attempts to determine the feasibility of reducing such corrosion by injecting steam at pipe entry to modify the boundary-layer gas composition along pipe walls. The injection will form a thin layer on the inner wall, preventing, for a time, contact with the corrosive gases. (Turbulence will eventually force diffusion through the protective layer.) The gas products are assumed to be hydrogen sulfide and steam. The Method of Integral Relations is used to obtain the numerical solutions to the governing equations. Finally, with several different injectant lengths and velocities, the concentration of H2S along the pipe wall is calculated and is found low enough to prevent corrosion.

  16. Integrated command, control, communication and computation system design study. Summary of tasks performed

    NASA Technical Reports Server (NTRS)

    1982-01-01

    A summary of tasks performed on an integrated command, control, communication, and computation system design study is given. The Tracking and Data Relay Satellite System command and control system study, an automated real-time operations study, and image processing work are discussed.

  17. SUMMARY REPORT: THE CAUSES AND CONTROL OF ACTIVATED SLUDGE BULKING AND FOAMING

    EPA Science Inventory

    This 92-page Technology Transfer Summary Report provides reference material on the causes and controls of sludge bulking and foaming in activated sludge treatment that can be readily understood, and it includes sufficient detail to help plant operators control their systems. The ...

  18. Telerobotic control of a mobile coordinated robotic server, executive summary

    NASA Technical Reports Server (NTRS)

    Lee, Gordon

    1993-01-01

    This interim report continues with the research effort on advanced adaptive controls for space robotics systems. In particular, previous results developed by the principle investigator and his research team centered around fuzzy logic control (FLC) in which the lack of knowledge of the robotic system as well as the uncertainties of the environment are compensated for by a rule base structure which interacts with varying degrees of belief of control action using system measurements. An on-line adaptive algorithm was developed using a single parameter tuning scheme. In the effort presented, the methodology is further developed to include on-line scaling factor tuning and self-learning control as well as extended to the multi-input, multi-output (MIMO) case. Classical fuzzy logic control requires tuning input scale factors off-line through trial and error techniques. This is time-consuming and cannot adapt to new changes in the process. The new adaptive FLC includes a self-tuning scheme for choosing the scaling factors on-line. Further the rule base in classical FLC is usually produced by soliciting knowledge from human operators as to what is good control action for given circumstances. This usually requires full knowledge and experience of the process and operating conditions, which limits applicability. A self-learning scheme is developed which adaptively forms the rule base with very limited knowledge of the process. Finally, a MIMO method is presented employing optimization techniques. This is required for application to space robotics in which several degrees-of-freedom links are commonly used. Simulation examples are presented for terminal control - typical of robotic problems in which a desired terminal point is to be reached for each link. Future activities will be to implement the MIMO adaptive FLC on an INTEL microcontroller-based circuit and to test the algorithm on a robotic system at the Mars Mission Research Center at North Carolina State University.

  19. Activated carbon injection - a mercury control success story

    SciTech Connect

    2008-07-01

    Almost 100 full-scale activated carbon injection (ACI) systems have been ordered by US electric utilities. These systems have the potential to remove over 90% of the mercury in flue, at a cost below $10,000 per pound of mercury removal. Field trials of ACI systems arm outlined. 1 fig.

  20. Summary Report on Beam and Radiation Generation, Monitoring and Control

    SciTech Connect

    Gordon, D. F.; Power, J. G.

    2009-01-22

    The discussions of the working group on beam and radiation generation, monitoring, and control (working group 6) at the 2008 advanced accelerator concepts workshop are summarized. The discussions concerned electron injectors, phase space manipulation, beam diagnostics, pulse train generation, intense beam physics, and radiation generation.

  1. STATIONARY COMBUSTION NOX CONTROL: A SUMMARY OF THE 1991 SYMPOSIUM

    EPA Science Inventory

    The 1991 Symposium on Stationary Combustion NOX Control was held March 25-28,1991 in Washington, DC. The sixth meeting in a biennial series, the Symposium was cosponsored by the Electric Power Research Institute (EPRI) and the U.S. Environmental Protection Agency (EPA). Approxima...

  2. Best infection control practices for intradermal, subcutaneous, and intramuscular needle injections.

    PubMed Central

    Hutin, Yvan; Hauri, Anja; Chiarello, Linda; Catlin, Mary; Stilwell, Barbara; Ghebrehiwet, Tesfamicael; Garner, Julia

    2003-01-01

    OBJECTIVE: To draw up evidence-based guidelines to make injections safer. METHODS: A development group summarized evidence-based best practices for preventing injection-associated infections in resource-limited settings. The development process included a breakdown of the WHO reference definition of a safe injection into a list of potentially critical steps, a review of the literature for each of these steps, the formulation of best practices, and the submission of the draft document to peer review. FINDINGS: Eliminating unnecessary injections is the highest priority in preventing injection-associated infections. However, when intradermal, subcutaneous, or intramuscular injections are medically indicated, best infection control practices include the use of sterile injection equipment, the prevention of contamination of injection equipment and medication, the prevention of needle-stick injuries to the provider, and the prevention of access to used needles. CONCLUSION: The availability of best infection control practices for intradermal, subcutaneous, and intramuscular injections will provide a reference for global efforts to achieve the goal of safe and appropriate use of injections. WHO will revise the best practices five years after initial development, i.e. in 2005. PMID:12973641

  3. Full-coverage film cooling heat transfer study: Summary of data for normal-hole injection and 30 deg slant-hole injection

    NASA Technical Reports Server (NTRS)

    Crawford, M. E.; Choe, H.; Kays, W. M.; Moffat, R. J.

    1976-01-01

    Heat transfer to a full coverage film cooled turbulent boundary layer over a flat surface was studied. The surface consisted of a discrete hole test section containing 11 rows of holes spaced 5 diameters apart in a staggered array and an instrumented recovery region. Ten diameter spacing was also studied by plugging appropriate holes. Two test sections were used, one having holes normal to the surface and the other having holes angled 30 deg to the surface in the downstream direction. Stanton number data were obtained both in the full coverage region and in the downstream recovery region for a range of blowing ratios, or mass flux ratios, from 0 to 1.3. Initial conditions at the upstream edge of the blowing region were varied from 500 to 5000 for momentum thickness Reynolds number and from 100 to 1800 for enthalpy thickness Reynolds number. The range of Reynolds numbers based on hole diameter and mainstream velocity was 6000 to 22000. Initial boundary layer thicknesses range from 0.5 to 2.0 hole diameters. Air was used as the working fluid. The data were taken for the secondary injection temperature equal to the wall temperature and also equal to the mainstream temperature. Superposition was then used to obtain Stanton number as a continuous function of the injectant temperature. The heat transfer coefficient was defined on the basis of a mainstream-to-wall temperature difference. This definition permits direct comparison of performance between film cooling and transpiration cooling.

  4. Crime Control Act of 1990 [29 November 1990]. [Summary].

    PubMed

    1990-01-01

    In the US, the Crime Control Act of 1990 was approved on November 29, 1990. This various titles of this Act include provisions relating to the following: 1) international money laundering; 2) child abuse; 3) child pornography; 4) kidnapping, abducting, or unlawfully restraining a child; 5) the protection of crime victims; 6) funding for local law enforcement agencies; 7) funding for federal law enforcement; 8) rural drug enforcement assistance; 9) mandatory detention for certain criminals; 10) juvenile justice; 11) penalties for use of certain firearms; 12) improvements in miscellaneous criminal law; 13) disability benefits for public safety officers; 14) money laundering; 15) drug-free school zones; 16) miscellaneous amendments to the federal judicial and criminal codes; 17) general provisions; 18) grants for correctional options; 19) control of anabolic steroids; 20) asset forfeiture; 21) student loan cancellation for law enforcement officers; 22) firearms provisions; 23) chemical diversion and trafficking; 24) drug paraphernalia; 25) banking law enforcement; 26) licit opium imports; 27) sentencing for methamphetamine offenses; 28) drug enforcement grants; 29) prisons; 30) shock incarceration (prison boot camps); 31) bankruptcy and restitution; 32) appropriations for law and drug enforcement agencies; 33) anti-drug programs; 34) support of law enforcement; 35) technical and minor substantive amendments to the federal criminal code; 36) federal debt collection; and 37) national child search assistance (for missing children).

  5. Flue gas injection control of silica in cooling towers.

    SciTech Connect

    Brady, Patrick Vane; Anderson, Howard L., Jr.; Altman, Susan Jeanne

    2011-06-01

    Injection of CO{sub 2}-laden flue gas can decrease the potential for silica and calcite scale formation in cooling tower blowdown by lowering solution pH to decrease equilibrium calcite solubility and kinetic rates of silica polymerization. Flue gas injection might best inhibit scale formation in power plant cooling towers that use impaired makeup waters - for example, groundwaters that contain relatively high levels of calcium, alkalinity, and silica. Groundwaters brought to the surface for cooling will degas CO{sub 2} and increase their pH by 1-2 units, possibly precipitating calcite in the process. Recarbonation with flue gas can lower the pHs of these fluids back to roughly their initial pH. Flue gas carbonation probably cannot lower pHs to much below pH 6 because the pHs of impaired waters, once outgassed at the surface, are likely to be relatively alkaline. Silica polymerization to form scale occurs most rapidly at pH {approx} 8.3 at 25 C; polymerization is slower at higher and lower pH. pH 7 fluids containing {approx}220 ppm SiO{sub 2} require > 180 hours equilibration to begin forming scale whereas at pH 8.3 scale formation is complete within 36 hours. Flue gas injection that lowers pHs to {approx} 7 should allow substantially higher concentration factors. Periodic cycling to lower recoveries - hence lower silica concentrations - might be required though. Higher concentration factors enabled by flue gas injection should decrease concentrate volumes and disposal costs by roughly half.

  6. Electron beam control using shock-induced density downramp injection

    NASA Astrophysics Data System (ADS)

    Swanson, K.; Tsai, H.-E.; Barber, S.; Lehe, R.; Mao, H.-S.; Steinke, S.; van Tilborg, J.; Geddes, C. G. R.; Leemans, W. P.

    2017-03-01

    In these experiments, we improve the quality of electrons injected along a shock-induced density downramp. We demonstrate that beam ellipticity and steering are influenced by the shock front tilt, and we present simple models to explain these effects. By adjusting the shock front angle, we minimize the beam's off-axis steering and ellipticity, producing high-quality electron beams over a tunable energy range.

  7. Remote Control Concrete Demolition System. Innovative Technology Summary Report

    SciTech Connect

    1998-12-01

    The Remote Control Concrete Demolition System (Brokk BM150) is a remote operated articulated hydraulic boom with various tool head attachments to perform the work. The machine is designed primarily to drive a hammer and has a reach of fifteen feet. The Brokk can be operated by someone 400 feet away or in a different room with a TV monitor. The machine can be operated up to a 30 degree gradient. The unit requires a 480 volt, 50 amp circuit for it's power source. Two attachments were used in this demonstration. The hydraulic hammer and the excavating bucket. The hammer operates at 600 foot pounds and has outputs of 1000 to 1500 beats per minute. The bucket had a capacity of 1/4 cubic yard and had a smooth cutting edge. Other attachments available include a concrete crusher, a La Bounty Shear, and a 1/4 yard clamshell bucket.

  8. Hanford 100-D Area Biostimulation Soluble Substrate Field Test: Interim Data Summary for the Substrate Injection and Process Monitoring Phases of the Field Test

    SciTech Connect

    Truex, Michael J.; Vermeul, Vincent R.; Mackley, Rob D.; Fritz, Brad G.; Mendoza, Donaldo P.; Johnson, Christian D.; Elmore, Rebecca P.; Brockman, Fred J.; Bilskis, Christina L.

    2008-06-01

    Pacific Northwest National Laboratory is conducting a treatability test designed to demonstrate that in situ biostimulation can be applied to help meet cleanup goals in the Hanford Site 100-D Area. The in situ biostimulation technology is intended to provide supplemental treatment upgradient of the In Situ Redox Manipulation (ISRM) barrier by reducing the concentration of the primary oxidizing species in groundwater (i.e., nitrate and dissolved oxygen) and chromate, and thereby increasing the longevity of the ISRM barrier. This report summarizes the initial results from field testing of an in situ biological treatment zone implemented through injection of a soluble substrate. The field test is divided into operational phases that include substrate injection, process monitoring, and performance monitoring. The results summarized herein are for the substrate injection and process monitoring phase encompassing the first approximately three months of field testing. Performance monitoring is ongoing at the time this report was prepared and is planned to extend over approximately 18 months. As such, this report is an interim data summary report for the field test. The treatability testing has multiple objectives focused on evaluating the performance of biostimulation as a reducing barrier for nitrate, oxygen, and chromate. The following conclusions related to these objectives are supported by the data provided in this report. Substrate was successfully distributed to a radius of about 15 m (50 ft) from the injection well. Monitoring data indicate that microbial growth initiated rapidly, and this rapid growth would limit the ability to inject substrate to significantly larger zones from a single injection well. As would be expected, the uniformity of substrate distribution was impacted by subsurface heterogeneity. However, subsequent microbial activity and ability to reduce the targeted species was observed throughout the monitored zone during the process monitoring

  9. Borehole Investigation of the Effectiveness of Grout Injection Technology on Coal Mine Subsidence Control

    NASA Astrophysics Data System (ADS)

    Xuan, Dayang; Xu, Jialin; Wang, Binglong; Teng, Hao

    2015-11-01

    Grout injection into the horizontal fracture at the bed separation of an overburden is used as a surface subsidence control measure in coal-producing countries such as Poland, China, and Australia. However, the stiffness and distribution of the grouting mass in the post-injected overburden, as well as its effect on surface subsidence control, have not been investigated. To address these issues, two surface boreholes were drilled into the post-injected overburden above a longwall panel on the study site. It was found that the fly ash injected more than 7 months previously had become compacted. More than 90 % of the total fill was concentrated in the main injection section (MIS) of the overburden (thickness of 4.8-18.4 m). The MIS was located between the bottom of the injection borehole and the key stratum immediately above. Following injection, the central gob area received the maximum possible compression and served as the foundation of the support for the grout, allowing the grout to restrain the deformation of the strata above it, thus reducing surface subsidence. The results of this investigation may facilitate future injection design, thus improving the control of surface subsidence.

  10. Some Factors Controlling the Seismic Hazard due to Earthquakes Induced by Fluid Injection at Depth

    NASA Astrophysics Data System (ADS)

    McGarr, A.

    2012-12-01

    The maximum seismic moment (or moment magnitude) is an important measure of the seismic hazard associated with earthquakes induced by deep fluid injection. Although it would be advantageous to be able to predict the induced earthquake outcome, including the maximum seismic moment, of a specified fluid injection project in advance, this capability has, to date, proved to be elusive because the geomechanical and hydrological factors that control the seismic response to injection are too poorly understood. Fortunately, the vast majority of activities involving the injection of fluids into deep aquifers do not cause earthquakes that are large enough to be of any consequence. There have been, however, significant exceptions during the past 50 years, starting with the earthquakes induced by injection of wastewater at the Rocky Mountain Arsenal Well, during the 1960s, that caused extensive damage in the Denver, CO, area. Results from numerous case histories of earthquakes induced by injection activities, including wastewater disposal at depth and the development of enhanced geothermal systems, suggest that it may be feasible to estimate bounds on maximum magnitudes based on the volume of injected liquid. For these cases, volumes of injected liquid ranged from approximately 11.5 thousand to 5 million cubic meters and resulted in main shock moment magnitudes from 3.4 to 5.3. Because the maximum seismic moment appears to be linearly proportional to the total volume of injected fluid, this upper bound is expected to increase with time as long as a given injection well remains active. For example, in the Raton Basin, southern Colorado and northern New Mexico, natural gas is produced from an extensive coal bed methane field. The deep injection of wastewater associated with this gas production has induced a sequence of earthquakes starting in August 2001, shortly after the beginning of major injection activities. Most of this seismicity defines a northeast striking plane dipping

  11. Simulation and experiment research on the proportional pressure control of water-assisted injection molding

    NASA Astrophysics Data System (ADS)

    Zhou, Hua; Chen, Yinglong; Zhang, Zengmeng; Yang, Huayong

    2012-05-01

    Water-assisted injection molding (WAIM), a newly developed fluid-assisted injection molding technology has drawn more and more attentions for the energy saving, short cooling circle time and high quality of products. Existing research for the process of WAIM has shown that the pressure control of the injecting water is mostly important for the WAIM. However, the proportional pressure control for the WAIM system is quite complex due to the existence of nonlinearities in the water hydraulic system. In order to achieve better pressure control performance of the injecting water to meet the requirements of the WAIM, the proportional pressure control of the WAIM system is investigated both numerically and experimentally. A newly designed water hydraulic system for WAIM is first modeled in AMEsim environment, the load characteristics and the nonlinearities of water hydraulic system are both considered, then the main factors affecting the injecting pressure and load flow rate are extensively studied. Meanwhile, an open-loop model-based compensation control strategy is employed to regulate the water injection pressure and a feedback proportional integrator controller is further adopted to achieve better control performance. In order to verify the AMEsim simulation results WAIM experiment for particular Acrylonitrile Butadiene Styrene (ABS) parts is implemented and the measured experimental data including injecting pressure and flow rate results are compared with the simulation. The good coincidence between experiment and simulation shows that the AMEsim model is accurate, and the tracking performance of the load pressure indicates that the proposed control strategy is effective for the proportional pressure control of the nonlinear WAIM system. The proposed proportional pressure control strategy and the conclusions drawn from simulation and experiment contribute to the application of water hydraulic proportional control and WAIM technology.

  12. Potential of foliar, dip, and injection applications of avermectins for control of plant-parasitic nematodes.

    PubMed

    Jansson, R K; Rabatin, S

    1998-03-01

    Studies were conducted to determine the potential of two avermectin compounds, abamectin and emamectin benzoate, for controlling plant-parasitic nematodes when applied by three methods: foliar spray, root dip, and pseudostem injection. Experiments were conducted against Meloidogyne incognita on tomato, M. javanica on banana, and Radopholus similis on banana. Foliar applications of both avermectins to banana and tomato were not effective for controlling any of the nematodes evaluated. Root dips of banana and tomato were moderately effective for controlling M. incognita on tomato and R. similis on banana. Injections (1 ml) of avermectins into banana pseudostems were effective for controlling M. javanica and R similis, and were comparable to control achieved with a conventional chemical nematicide, fenamiphos. Injections of 125 to 2,000 mug/plant effectively controlled one or both nematodes on banana; abamectin was more effective than emamectin benzoate for controlling nematodes.

  13. Potential of Foliar, Dip, and Injection Applications of Avermectins for Control of Plant-Parasitic Nematodes

    PubMed Central

    Jansson, Richard K.; Rabatin, Susan

    1998-01-01

    Studies were conducted to determine the potential of two avermectin compounds, abamectin and emamectin benzoate, for controlling plant-parasitic nematodes when applied by three methods: foliar spray, root dip, and pseudostem injection. Experiments were conducted against Meloidogyne incognita on tomato, M. javanica on banana, and Radopholus similis on banana. Foliar applications of both avermectins to banana and tomato were not effective for controlling any of the nematodes evaluated. Root dips of banana and tomato were moderately effective for controlling M. incognita on tomato and R. similis on banana. Injections (1 ml) of avermectins into banana pseudostems were effective for controlling M. javanica and R similis, and were comparable to control achieved with a conventional chemical nematicide, fenamiphos. Injections of 125 to 2,000 μg/plant effectively controlled one or both nematodes on banana; abamectin was more effective than emamectin benzoate for controlling nematodes. PMID:19274200

  14. Can Earthquakes Induced by Deep Fluid Injection Projects Be Controlled or Limited?

    NASA Astrophysics Data System (ADS)

    McGarr, A.; Williams, C. F.; Hickman, S.; Oppenheimer, D. H.

    2011-12-01

    Projects that involve the injection of high-pressure fluids at depth include Enhanced Geothermal Systems (EGS), CO2 sequestration and liquid waste disposal. We consider some case histories to address the question of the extent to which earthquakes induced by fluid injection can be controlled or limited. For instance, can induced earthquakes be controlled in ways that don't compromise the effectiveness of a given injection project? It is difficult to answer this question definitively because, to our knowledge, only one successful experiment in earthquake control has been performed (Raleigh et al., Science, v. 191, pp. 1230-1237, 1976). Moreover, for numerous injection projects, the induced earthquakes of maximum magnitude have been post shut-in, e.g., the Rocky Mountain Arsenal well, a liquid waste disposal project for which the three largest induced earthquakes occurred more than a year after injection had been terminated. For EGS operations requiring the injection of liquid into rock of low permeability, estimations of maximum magnitudes based on the volume of injected fluid have been moderately successful. For a typical magnitude distribution of induced earthquakes, it can be shown that the largest event accounts for about half of the total induced seismic moment, which is given by the volume of injected liquid multiplied by the modulus of rigidity (McGarr, J. Geophys. Res., v. 81, p. 1487, 1976). The Basel Deep Heat Mining project, an EGS injection of 11,500 cubic meters of water into low-permeability rock at a depth of five km, induced earthquakes with magnitudes that exceeded the safety threshold and so injection was discontinued (Deichmann and Giardini, Seismol. Res. Letters, v. 80, p. 784, 2009). Approximately half a day after shut-in, however, an earthquake of magnitude 3.4 occurred, the largest event of the sequence. It is worth noting that the magnitude of this earthquake is quite close to what could have been estimated based on the volume of injected

  15. Active Flow Separation Control of a Stator Vane Using Surface Injection in a Multistage Compressor Experiment

    NASA Technical Reports Server (NTRS)

    Culley, Dennis E.; Bright, Michelle M.; Prahst, Patricia S.; Strazisar, Anthony J.

    2003-01-01

    Micro-flow control actuation embedded in a stator vane was used to successfully control separation and improve near stall performance in a multistage compressor rig at NASA Glenn. Using specially designed stator vanes configured with internal actuation to deliver pulsating air through slots along the suction surface, a research study was performed to identify performance benefits using this microflow control approach. Pressure profiles and unsteady pressure measurements along the blade surface and at the shroud provided a dynamic look at the compressor during microflow air injection. These pressure measurements lead to a tracking algorithm to identify the onset of separation. The testing included steady air injection at various slot locations along the vane. The research also examined the benefit of pulsed injection and actively controlled air injection along the stator vane. Two types of actuation schemes were studied, including an embedded actuator for on-blade control. Successful application of an online detection and flow control scheme will be discussed. Testing showed dramatic performance benefit for flow reattachment and subsequent improvement in diffusion through the use of pulsed controlled injection. The paper will discuss the experimental setup, the blade configurations, and preliminary CFD results which guided the slot location along the blade. The paper will also show the pressure profiles and unsteady pressure measurements used to track flow control enhancement, and will conclude with the tracking algorithm for adjusting the control.

  16. Assessing sorbent injection mercury control effectiveness in flue gas streams

    USGS Publications Warehouse

    Carey, T.R.; Richardson, C.F.; Chang, R.; Meserole, F.B.; Rostam-Abadi, M.; Chen, S.

    2000-01-01

    One promising approach for removing mercury from coal-fired, utility flue gas involves the direct injection of mercury sorbents. Although this method has been effective at removing mercury in municipal waste incinerators, tests conducted to date on utility coal-fired boilers show that mercury removal is much more difficult in utility flue gas. EPRI is conducting research to investigate mercury removal using sorbents in this application. Bench-scale, pilot-scale, and field tests have been conducted to determine the ability of different sorbents to remove mercury in simulated and actual flue gas streams. This paper focuses on recent bench-scale and field test results evaluating the adsorption characteristics of activated carbon and fly ash and the use of these results to develop a predictive mercury removal model. Field tests with activated carbon show that adsorption characteristics measured in the lab agree reasonably well with characteristics measured in the field. However, more laboratory and field data will be needed to identify other gas phase components which may impact performance. This will allow laboratory tests to better simulate field conditions and provide improved estimates of sorbent performance for specific sites. In addition to activated carbon results, bench-scale and modeling results using fly ash are presented which suggest that certain fly ashes are capable of adsorbing mercury.

  17. Frequency stabilization in injection controlled pulsed CO2 lasers

    NASA Technical Reports Server (NTRS)

    Menzies, Robert T.; Ancellet, Gerard M.

    1987-01-01

    Longitudinal mode selection by injection has been demonstrated as a viable technique for tailoring a TEA-CO2 laser with pulse energies of a Joule or greater to fit the requirements of a coherent lidar transmitter. Once reliable generation of single-longitudinal-mode (SLM) pulses is obtained, one can study the intrapulse frequency variation and attempt to determine the sources of frequency sweeping, or chirp. These sources include the effect of the decaying plasma, the thermal gradient due to the energy dissipation associated with the laser mechanism itself, and the pressure shift of the center frequency of the laser transition. The use of the positive-branch unstable resonator as an efficient means of coupling a discharge with transverse spatial dimensions of the order of centimeters to an optical cavity mode introduces another concern: namely, what can be done to emphasize transverse mode discrimination in an unstable resonator cavity while maintaining high coupling efficiency. These issues are briefly discussed in the paper, and representative experimental examples are included.

  18. PAB3D Simulations of a Nozzle with Fluidic Injection for Yaw Thrust-Vector Control

    NASA Technical Reports Server (NTRS)

    Deere, Karen A.

    1998-01-01

    An experimental and computational study was conducted on an exhaust nozzle with fluidic injection for yaw thrust-vector control. The nozzle concept was tested experimentally in the NASA Langley Jet Exit Test Facility (JETF) at nozzle pressure ratios up to 4 and secondary fluidic injection flow rates up to 15 percent of the primary flow rate. Although many injection-port geometries and two nozzle planforms (symmetric and asymmetric) were tested experimentally, this paper focuses on the computational results of the more successful asymmetric planform with a slot injection port. This nozzle concept was simulated with the Navier-Stokes flow solver, PAB3D, invoking the Shih, Zhu, and Lumley algebraic Reynolds stress turbulence model (ASM) at nozzle pressure ratios (NPRs) of 2,3, and 4 with secondary to primary injection flow rates (w(sub s)/w(sub p)) of 0, 2, 7 and 10 percent.

  19. Medroxyprogesterone Injection

    MedlinePlus

    ... Medroxyprogesterone injection is a very effective method of birth control but does not prevent the spread of human ... you have been using a different method of birth control and are switching to medroxyprogesterone injection, your doctor ...

  20. Method of controlling injection of oxygen into hydrogen-rich fuel cell feed stream

    DOEpatents

    Meltser, Mark Alexander; Gutowski, Stanley; Weisbrod, Kirk

    2001-01-01

    A method of operating a H.sub.2 --O.sub.2 fuel cell fueled by hydrogen-rich fuel stream containing CO. The CO content is reduced to acceptable levels by injecting oxygen into the fuel gas stream. The amount of oxygen injected is controlled in relation to the CO content of the fuel gas, by a control strategy that involves (a) determining the CO content of the fuel stream at a first injection rate, (b) increasing the O.sub.2 injection rate, (c) determining the CO content of the stream at the higher injection rate, (d) further increasing the O.sub.2 injection rate if the second measured CO content is lower than the first measured CO content or reducing the O.sub.2 injection rate if the second measured CO content is greater than the first measured CO content, and (e) repeating steps a-d as needed to optimize CO consumption and minimize H.sub.2 consumption.

  1. A summary of laser and microwave flow control in high-speed flows

    NASA Astrophysics Data System (ADS)

    Knight, D.

    2013-06-01

    Laser and microwave discharge in air has emerged as an effective method for flow control in high-speed flows. Computational and experimental research has demonstrated its capability for significant drag reduction and mitigation of adverse interactions in high-speed flows. The paper presents a summary of key computational and experimental studies performed at Rutgers University in collaboration with the Joint Institute for High Temperatures (Moscow, Russia) and St. Petersburg State University (St. Petersburg, Russia).

  2. Impact of the underground injection control program on energy resource development

    SciTech Connect

    Allen, E.P.

    1983-10-01

    Part C of the Safe Drinking Water Act requires that underground sources of drinking water be protected from endangerment by well injection. The Act, as amended through 1980, and the resultant Underground Injection Control (UIC) program regulations and guidance describe minimum requirements for achieving this protection. Injection wells used in the development of energy resources, for example, those related to oil and natural gas production, and the solution mining of uranium, are regulated under the UIC program. The major features of the program requirements that affect such energy related wells are considered here from the Federal-Regional perspective.

  3. Class I Underground Injection Control Program: Study of the Risks Associated with Class I Underground Injection Wells

    EPA Pesticide Factsheets

    The document provides describes the current Class I UIC program, the history of Class I injection, and studies of human health risks associated with Class I injection wells, which were conducted for past regulatory efforts and policy documentation.

  4. Percutaneous Cyanoacrylate Glue Injection into the Renal Pseudoaneurysm to Control Intractable Hematuria After Percutaneous Nephrolithotomy

    SciTech Connect

    Lal, Anupam Kumar, Ajay; Prakash, Mahesh; Singhal, Manphool; Agarwal, Mayank Mohan; Sarkar, Debansu; Khandelwal, Niranjan

    2009-07-15

    We report a case of a 43-year-old man who developed intractable hematuria after percutaneous nephrolithotomy. Angiography detected a pseudoaneurysm arising from the lower polar artery; however, embolization could not be performed because of unfavorable vascular anatomy. A percutaneous thrombin injection under ultrasound guidance initially controlled the bleeding, but hematuria subsequently recurred as a result of recanalization of the aneurysm. The case was successfully managed with ultrasound- and fluoroscopic-guided direct injection of cyanoacrylate glue into the pseudoaneurysm.

  5. Percutaneous cyanoacrylate glue injection into the renal pseudoaneurysm to control intractable hematuria after percutaneous nephrolithotomy.

    PubMed

    Lal, Anupam; Kumar, Ajay; Prakash, Mahesh; Singhal, Manphool; Agarwal, Mayank Mohan; Sarkar, Debansu; Khandelwal, Niranjan

    2009-07-01

    We report a case of a 43-year-old man who developed intractable hematuria after percutaneous nephrolithotomy. Angiography detected a pseudoaneurysm arising from the lower polar artery; however, embolization could not be performed because of unfavorable vascular anatomy. A percutaneous thrombin injection under ultrasound guidance initially controlled the bleeding, but hematuria subsequently recurred as a result of recanalization of the aneurysm. The case was successfully managed with ultrasound- and fluoroscopic-guided direct injection of cyanoacrylate glue into the pseudoaneurysm.

  6. Pressure-controlled injection of guar gum stabilized microscale zerovalent iron for groundwater remediation.

    PubMed

    Luna, M; Gastone, F; Tosco, T; Sethi, R; Velimirovic, M; Gemoets, J; Muyshondt, R; Sapion, H; Klaas, N; Bastiaens, L

    2015-10-01

    The paper reports a pilot injection test of microsized zerovalent iron (mZVI) dispersed in a guar gum shear thinning solution. The test was performed in the framework of the EU research project AQUAREHAB in a site in Belgium contaminated by chlorinated aliphatic hydrocarbons (CAHs). The field application was aimed to overcome those critical aspects which hinder mZVI field injection, mainly due to the colloidal instability of ZVI-based suspensions. The iron slurry properties (iron particles size and concentration, polymeric stabilizer type and concentration, slurry viscosity) were designed in the laboratory based on several tests (reactivity tests towards contaminants, sedimentation tests and rheological measurements). The particles were delivered into the aquifer through an injection well specifically designed for controlled-pressure delivery (approximately 10 bars). The well characteristics and the critical pressure of the aquifer (i.e. the injection pressure above which fracturing occurs) were assessed via two innovative injection step rate tests, one performed with water and the other one with guar gum. Based on laboratory and field preliminary tests, a flow regime at the threshold between permeation and preferential flow was selected for mZVI delivery, as a compromise between the desired homogeneous distribution of the mZVI around the injection point (ensured by permeation flow) and the fast and effective injection of the slurry (guaranteed by high discharge rates and injection pressure, resulting in the generation of preferential flow paths). A monitoring setup was designed and installed for the real-time monitoring of relevant parameters during injection, and for a fast determination of the spatial mZVI distribution after injection via non-invasive magnetic susceptibility measurements.

  7. Optimization of Trona/Limestone Injection for SO2 Control in Coal-Fired Boilers

    SciTech Connect

    2005-09-01

    Mobotec USA develops and markets air pollution control systems for utility boilers and other combustion systems. They have a particular interest in technologies that can reduce NOx, SOx, and mercury emissions from coal-fired boilers, and have been investigating the injection of sorbents such as limestone and trona into a boiler to reduce SOx and Hg emissions. WRI proposed to use the Combustion Test Facility (CTF) to enable Mobotec to conduct a thorough evaluation of limestone and trona injection for SO{sub 2} control. The overall goal of the project was to characterize the SO{sub 2} reductions resulting from the injection of limestone and trona into the CTF when fired with a high-sulfur eastern bituminous coal used in one of Mobotec's Midwest installations. Results revealed that when limestone was injected at Ca:S molar ratios of 1.5 to 3.0, the resulting SO{sub 2} reductions were 35-55%. It is believed that further reductions can be attained with improved mixing of the sorbent with the combustion gases. When limestone was added to the coal, at Ca:S molar ratios of 0.5 to 1.5, the SO{sub 2} reductions were 13-21%. The lower reductions were attributed to dead-burning of the sorbent in the high temperature flame zone. In cases where limestone was both injected into the furnace and added to the coal, the total SO{sub 2} reductions for a given Ca:S molar ratio were similar to the reductions for furnace injection only. The injection of trona into the mid-furnace zone, for Na:S molar ratios of 1.4 to 2.4, resulted in SO{sub 2} reductions of 29-43%. Limestone injection did not produce any slag deposits on an ash deposition probe while trona injection resulted in noticeable slag deposition.

  8. Heated carrier fluids in decreasing propofol injection pain: a randomized, controlled trial

    PubMed Central

    Hsu, Tzung-Min

    2017-01-01

    Background Propofol is a commonly used intravenous drug during anesthetic induction because of its rapid onset and short duration. However, the injection pain that patients experience is so severe that they recall the induction of anesthesia as the most painful part of the perioperative period. Therefore, the objective of this study was to determine the effect of heated carrier fluids (40℃) in decreasing propofol injection pain. Methods A randomized, controlled clinical trial was conducted in 90 patients aged 18 to 65 who were scheduled for either elective or urgent surgery under general anesthesia classified as American Society of Anesthesiologists physical status I or II. Patients were allocated into the following 3 groups: 1) Group W (n = 30) who received 200 ml of heated carrier fluids for 20 minutes prior to propofol injection; 2) Group L (n = 30) who received 200 ml of heated carrier fluids for 20 minutes prior to 0.5 mg/kg 1%lidocaine 1 minute before propofol injection; 3) Group C (control group, n = 30) who received 200 ml of room temperature fluids prior to propofol injection. Pain was evaluated using verbal pain score (VPS). Results Group W and Group L showed significant reduction (P = 0.001) in the incidence and severity of injection pain compared to Group C. VPS scores were significantly lower in Group W and Group L compared to those of Group C. Incidence of propofol injection pain was statistically different between Group W (P = 0.005) and Group L (P = 0.037) compared to Group C, but not statistically different between Group W and Group L (P = 0.432). Conclusions Both sole injection of heated carrier fluids and the combination of 0.5 mg/kg 1%lidocaine pretreatment effectively reduced propofol injection pain. PMID:28184264

  9. Application of Sequence Control Injection in Modified Design of Car Front Bumper

    NASA Astrophysics Data System (ADS)

    Feng, Wang; Guodong, Chen; Jiling, Bu; Bin, Zhou

    2014-08-01

    In view of lightweight and cost reduction, a bumper has been redesigned, which results in weld lines during the manufacture. For that, a new method of sequence control technology is introduced. The simulation results with the new method and the traditional method were compared. The results showed that the weld lines were removed, and at the same time, the injection balance was better and the injection pressure was decreased by using the sequence control technology. The sequence control technology is of great practical significance to bumper manufacturing.

  10. SOLERAS - Solar Controlled Environment Agriculture Project. Final report, Volume 1. Project summary

    SciTech Connect

    Not Available

    1985-12-30

    A summary of the Solar Controlled Environment Agriculture Project is presented. The design of the greenhouses include transparent double pane glass roof with channels for fluid between the panes, inner pane tinted and double pane extruded acrylic aluminized mylar shade and diffuser. Solar energy technologies provide power for water desalination, for pumping irrigation water, and for cooling and heating the controlled environment space so that crops can grow in arid lands. The project is a joint effort between the United States and Saudi Arabia. (BCS)

  11. A summary of the Dynamics Explorer /DE/-2 spacecraft attitude control operations and dynamics

    NASA Technical Reports Server (NTRS)

    Stengle, T. H.

    1982-01-01

    A summary of attitude control operations and observed attitude dynamics for the Dynamics Explorer (DE)-2 spacecraft is presented. By performing a systematic analysis of spacecraft drift and through optimization of modeling parameters in dynamics simulators, insight is given into spacecraft dynamics, techniques for reducing drift, and methods for streamlining operational procedures. This paper discusses how attitude and momentum drift were reduced for DE-2 by changing spacecraft geometry, altering operational procedures and making timely use of the control modes available. Attempts to correlate spacecraft drift activity with known environmental variables are made with only limited success.

  12. Controle de la fabrication des composites par injection sur renforts

    NASA Astrophysics Data System (ADS)

    Lebel, Francois

    Liquid Composite Molding (LCM) is an increasingly used class of processes to manufacture high performance composites. A multiscale study is presented in this thesis in order to better understand the fundamental physics of impregnation and air entrapment phenomena in dual scale fibrous reinforcements and thus propose practical solutions for process control engineers. First of all, an experimental setup is developed to study the saturation of fibrous reinforcements, at the macroscopic scale, during the Resin Transfer Molding (RTM). This setup is used to determine some key parameters of the part filling step and industrial post-filling strategies (mold bleeding and consolidation) that control the impregnation quality of fibrous reinforcements. These key parameters are identified using three series of experiments. These parameters are the flow front velocity, the inlet mold pressure and the bleeding flow rate. The analyses in these three series of experiments are based on an ASTM standard procedure for void content determination in the composite parts by carbonization (also called loss on ignition (LOI)). These three series of experiments have related a posteriori the key parameters of LCM processes to phenomena of void formation, migration and dissolution in composite parts made of E-glass non crimp fabric (NCF) and vinyl ester resin. The second part of this thesis aims to investigate, at the mesoscopic and microscopic scale, the impregnation mechanisms of fibrous reinforcements during LCM processes. This analysis focuses more specifically on wicking phenomenon in fiber tows and in fibrous laminates, namely here stacks of non crimp fabric plies. This experimental study is carried out to better understand the physics which explain that the impregnation velocity is one of the key parameters that control the quality of composite parts manufactured by LCM processes. This analysis also aims to identify the structural features of fiber tows and fibrous reinforcements that

  13. Improved diabetic control in adolescents using the Penject syringe for multiple insulin injections.

    PubMed

    McCaughey, E S; Betts, P R; Rowe, D J

    1986-05-01

    Eleven adolescent diabetics, aged 15.1 +/- 1.3 years (mean +/- 1SD) in poor glycaemic control (HbA1 12.0 +/- 1.5% at entry) were commenced on a four times daily insulin injection regimen using the Penject fountain-pen syringe with Initard (50:50 mixture of porcine soluble and isophane) insulin on a sliding scale. Diabetic control improved over a 3-month period, assessed by a reduction in both the mean preprandial blood glucose concentrations (10.9 +/- 3.3 mmol/l to 7.7 +/- 2.3 mmol/l) and mean glycosylated haemoglobin concentrations (12.0 +/- 1.5% to 9.5 +/- 0.9%). Further improvement was again seen in 5 patients who remained on four daily injections for an additional 3 months (mean HbA1: 9.6 +/- 0.9% to 8.4 +/- 1.0%), whereas diabetic control in 6 patients who returned to twice daily injections deteriorated (mean HbA1 rose from 9.5 +/- 1.0% to 10.6 +/- 1.6%). Multiple insulin injections using an injection pen are acceptable to adolescent diabetics and improve their control.

  14. Integrated dry NO{sub x}/SO{sub 2} emissions control system performance summary

    SciTech Connect

    Hunt, T.; Muzio, L.J.; Smith, R.; Jones, D.; Hebb, J.L.; Stallings, J.

    1997-12-31

    The Integrated Dry NO{sub x}/SO{sub 2} Emissions Control System was installed at Public Service Company of Colorado`s Arapahoe 4 generating station in 1992 in cooperation with the US Department of Energy (DOE) and the Electric Power Research Institute (EPRI). This full-scale 100 MWe demonstration combines low-NO{sub x} burners, overfire, air, and selective non-catalytic reduction (SNCR) for NO{sub x} control and dry sorbent injection (DSI) with or without humidification for SO{sub 2} control. Operation and testing of the Integrated Dry NO{sub x}/SO{sub 2} Emissions Control System began in August 1992 and will continue through 1996. Results of the NO{sub x} control technologies show that the original system goal of 70% NO{sub x} removal has been easily met and the combustion and SNCR systems can achieve NO{sub x} removals of up to 80% at full load. Duct injection of commercial calcium hydroxide has achieved a maximum SO{sub 2} removal of nearly 40% while humidifying the flue gas to a 20 F approach to saturation. Sodium-based dry sorbent injection has provided SO{sub 2} removal of over 70% without the occurrence of a visible NO{sub 2} plume. Recent test work has improved SNCR performance at low loads and has demonstrated that combined dry sodium injection and SNCR yields both lower NO{sub 2} levels and NH{sub 3} slip than either technology alone.

  15. Control of oscillations and NOx concentrations in ducted premixed flames by spray injection of water

    SciTech Connect

    Sivasegaram, S.; Tsai, R.F.; Whitelaw, J.H.

    1995-12-31

    The antinodal rms pressure fluctuations of a ducted premixed flame has been reduced from 9 to 1.75 kPa by pulsed injection of water with heat removal of less than 3% of the total heat release of 150 kW. A corresponding benefit was the reduction in NO{sub x} emissions from 65 to 30 ppm. Several control strategies were considered and active control based on the oscillation of injection at the same phase as that of the oscillations was found to provide the best combination of attenuation and NO{sub x} reduction.

  16. Uptake and distribution of specific and control monoclonal antibodies in subcutaneous xenografts following intratumor injection

    SciTech Connect

    Rowlinson-Busza, G.; Bamias, A.; Krausz, T.; Epenetos, A.A. )

    1991-06-15

    Nude mice bearing s.c. xenografts of the human colon adenocarcinoma HT29 were given intratumor injections of a mixture of 125I-labeled specific antibody (AUA1) and 131I-labeled control antibody (HMFG1), or with the labels reversed. After dissection at 1 and 4 h postadministration, both specific and control antibodies had 47-63% of the injected dose (% ID) in the tumor. By 24 h, the tumor contained 43 {plus minus} 11% ID of AUA1 which persisted at around this level for 5 days and remained at nearly 20% ID at 18 days. In contrast, the HMFG1 activity was 23 {plus minus} 9% ID at 24 h, which continued to fall and was less than 5% ID by 7 days. Normal organ levels were less than 2% ID/g for both antibodies, with HMFG1 being higher than AUA1 at all times, resulting in specificity indices greater than 20 by 5 days. Autoradiography of tumors removed 2 h postinjection of 125I-labeled AUA1 or HMFG1 showed high levels of antibody at the injection site. At 48 h and 7 days postinjection, the specific antibody was bound to the surface of tumor cells in islands remote from the injection site, whereas the control antibody was found only in the stroma and blood vessels, or as diffuse nonspecific uptake. These data indicate that intratumor injection of radiolabeled monoclonal antibodies may achieve high radiation doses in accessible tumors without systemic irradiation.

  17. Strategies and Decision Support Systems for Integrating Variable Energy Resources in Control Centers for Reliable Grid Operations. Executive Summary

    SciTech Connect

    Jones, Lawrence E.

    2011-11-01

    This is the executive summary for a report that provides findings from the field regarding the best ways in which to guide operational strategies, business processes and control room tools to support the integration of renewable energy into electrical grids.

  18. Paraspinous Lidocaine Injection for Chronic Nonspecific Low Back Pain: A Randomized Controlled Clinical Trial

    PubMed Central

    Imamura, Marta; Imamura, Satiko Tomikawa; Targino, Rosa Alves; Morales-Quezada, León; Onoda Tomikawa, Luis C.; Onoda Tomikawa, Luis G.; Alfieri, Fabio M.; Filippo, Thais R.; da Rocha, Ivan D.; Neto, Raul Bolliger; Fregni, Felipe; Battistella, Linamara Rizzo

    2016-01-01

    In this large, sham-controlled, randomized trial, we examined the efficacy of the combination of standard treatment and paraspinous lidocaine injection compared with standard therapy alone in subjects with chronic low back pain. There is little research-based evidence for the routine clinical use of paraspinous lidocaine injection for low back pain. A total of 378 subjects with nonspecific chronic low back pain were randomized to 3 groups: paraspinous lidocaine injection, analgesics, and exercises (group 1, LID-INJ); sham paraspinous lidocaine injection, analgesics, and exercises (group 2, SH-INJ); and analgesics and exercises (group 3, STD-TTR). A blinded rater assessed the study outcomes at 3 time points: baseline, after treatment, and after 3 months of follow-up. There were increased frequency of pain responses and better low back functional scores in the LID-INJ group compared with the SH-INJ and STD-TTR groups. These effects remained at the 3-month follow-up but differed between all 3 groups. There were significant changes in pain threshold immediately after treatment, supporting the effects of this intervention in reducing central sensitization. Paraspinous lidocaine injection therapy is not associated with a higher risk of adverse effects compared with conventional treatment and sham injection. Its effects on hyperalgesia might correlate with changes in central sensitization. PMID:26828801

  19. Fast electron spin resonance controlled manipulation of spin injection into quantum dots

    SciTech Connect

    Merz, Andreas Siller, Jan; Schittny, Robert; Krämmer, Christoph; Kalt, Heinz; Hetterich, Michael

    2014-06-23

    In our spin-injection light-emitting diodes, electrons are spin-polarized in a semimagnetic ZnMnSe spin aligner and then injected into InGaAs quantum dots. The resulting electron spin state can be read out by measuring the circular polarization state of the emitted light. Here, we resonantly excite the Mn 3d electron spin system with microwave pulses and perform time-resolved measurements of the spin dynamics. We find that we are able to control the spin polarization of the injected electrons on a microsecond timescale. This electron spin resonance induced spin control could be one of the ingredients required to utilize the quantum dot electrons or the Mn spins as qubits.

  20. Tentative fingerprint-efficacy study of Houttuynia cordata injection in quality control of traditional Chinese medicine.

    PubMed

    Lu, Hong-Mei; Liang, Yi-Zeng; Wu, Xian-Jin; Qiu, Ping

    2006-05-01

    To establish potent fingerprint for quality control of traditional Chinese medicine, Houttuynia cordata (Saururaceae) injection (HCI), the attempt on fingerprint-efficacy was developed in this study. HCI from ten different factories were determined by gas chromatography-mass spectrum (GC-MS) and classified by hierarchical clustering. The anti-inflammatory effect of HCI was characterized with the rat pleurisy model induced by carrageenin and the mice ear edema model by xylene. The results showed that anti-inflammatory effect of the injections from most of factories on the two models was significant. There was corresponding relationship between the fingerprint of HCI and efficacy to certain extent. The main common constitutes in injection from the factories that possess anti-inflammatory activity were analysed with GC-MS and identified using the NIST Mass Spectral Database. This common pattern of HCI based on the efficacy was helpful for the purpose of quality control.

  1. Study on Model Based Combustion Control of Diesel Engine with Multi Fuel Injection

    NASA Astrophysics Data System (ADS)

    Ikemura, R.; Yamasaki, Y.; Kaneko, S.

    2016-09-01

    A controller for model-based control of diesel engine with triple injection were developed with a combustion model. In the combustion model, an engine cycle is discretized into several representative points in order to improve calculation speed, while physical equations are employed to expand the versatility. The combustion model can predict in-cylinder pressure and temperature in these discrete points. Prediction accuracy of the combustion model was evaluated by comparison with experimental result. A controller was designed with the combustion model in order to calculate optimal fuel injection pattern for controlling in-cylinder pressure peak timing. The controller's performance was evaluated through simulation in which the combustion model was used as a plant model.

  2. Summary tables of six commercially available entry control and contraband detection technologies.

    SciTech Connect

    Hunter, John Anthony

    2005-07-01

    Existing contraband detection and entry control devices such as metal detectors, X-ray machines, and radiation monitors were investigated for their capability to operate in an automated environment. In addition, a limited number of new devices for detection of explosives, chemicals, and biological agents were investigated for their feasibility for inclusion in future physical security systems. The tables in this document resulted from this investigation, which was part of a conceptual design upgrade for the United States Mints. This summary of commercially available technologies was written to provide a reference for physical security upgrades at other sites.

  3. New kind of injection-locked oscillator and its corresponding long-term stability control.

    PubMed

    Hong, Jun; Liu, An; Wang, Xiao-hu; Yao, Sheng-xing; Li, Zu-ling

    2015-09-20

    A new type of opto-electronic hybrid oscillator is proposed for the first time, to the best of our knowledge, and verified by experiments in this paper. Typical electronic oscillator-dielectric resonator oscillator as the first injection source is used to injection lock the first long-fiber loop-based opto-electronic oscillator (OEO); then its output is used to injection lock the second long-fiber opto-electronic oscillator. Using this method, low-phase noise output signal can be obtained. Experiments show that single side-band (SSB) phase noise of a 9.5 GHz oscillation signal at 10 kHz offset frequency decreases from -123 to -135  dBc/Hz after the first injection, then, through the second injection, the SSB phase noise drops down to -146  dBc/Hz. In order to solve the long-term stability problem of the above oscillator, a new stability-control circuit also is designed and verified by experiments. Experiments show that the Allan deviation decreases from 9.0×10(-11) to 2.2×10(-12) during 1 s after the long-term stability-control circuit being used.

  4. The effectiveness of a double-stem injection valve in controlling combustion in a compression-ignition engine

    NASA Technical Reports Server (NTRS)

    Spanogle, J A; Whitney, E G

    1931-01-01

    An investigation was made to determine to what extent the rates of combustion in a compression-ignition engine can be controlled by varying the rates of fuel injection. The tests showed that the double-stem valve operated satisfactorily under all normal injection conditions; the rate of injection has a definite effect on the rate of combustion; the engine performance with the double-stem valve was inferior to that obtained with a single-stem valve; and the control of injection rates permitted by an injection valve of two stages of discharge is not sufficient to effect the desired rates of combustion.

  5. Summary of Resources for the International Space Station Environmental Control and Life Support System

    NASA Technical Reports Server (NTRS)

    Williams, David E.

    2003-01-01

    The assembly complete Environmental Control and Life Support (ECLS) s ystem for the International Space Station (ISS) will consist of compo nents and subsystems in both the U.S. and International partner eleme nts which together will perform the functions of Temperature and Hum idity Control (THC), Atmosphere Control and Supply (ACS), Atmosphere Revitalization (AR), Water Recovery and Management (WRM), Fire Detect ion and Suppression (FDS), and Vacuum System (VS) for the station. D ue to limited resources available on ISS, detailed attention is given to minimizing and tracking all resources associated with all systems , beginning with estimates during the hardware development phase thr ough measured actuals when flight hardware is built and delivered. A summary of resources consumed by the current on-orbit U.S. ECLS syste m hardware is presented, including launch weight, average continuous and peak power loads, on-orbit volume and resupply logistics. ..

  6. EMISSION TEST REPORT- FIELD TEST OF CARBON INJECTION FOR MERCURY CONTROL, CAMDEN COUNTY MUNICIPAL WASTE COMBUSTOR

    EPA Science Inventory

    The report gives results of parametric test to evaluate the injection powdered activated carbon to control volatile pollutants in municipal waste combustor (MWC) flue gas. he tests were conducted at a spray dryer absorber/electrostatic precipitator (SD/ESP)-equipped MWC in Camden...

  7. TEST DESIGN FOR ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) OF ADD-ON NOX CONTROL UTILIZING OZONE INJECTION

    EPA Science Inventory

    The paper discusses the test design for environmental technology verification (ETV) of add-0n nitrogen oxides (NOx) control utilizing ozone injection. (NOTE: ETV is an EPA-established program to enhance domestic and international market acceptance of new or improved commercially...

  8. Pulsed Injection Flow Control for Throttling in Supersonic Nozzles - A Computational Fluid Dynamics Design Study (Preprint)

    DTIC Science & Technology

    2007-05-14

    other high temperature real gas effects. Although such effects are relevant when numerically 4 assessing rocket engine performance, the fundamental...Study of Rocket Thrust Control by Gas Injection,” Massachusetts Institite of Technolog, Naval Supersonic Laboratory, Technical Report 448...because of its space access mission. However, potential cadidates for this technology include gas turbines and rockets whose application required the

  9. Controlled release of protein from biodegradable multi-sensitive injectable poly(ether-urethane) hydrogel.

    PubMed

    Li, Xiaomeng; Wang, Yangyun; Chen, Jiaming; Wang, Yinong; Ma, Jianbiao; Wu, Guolin

    2014-03-12

    The synthesis and characterization of multi-sensitive polymers for use as injectable hydrogels for controlled protein/drug delivery is reported. A series of biodegradable multi-sensitive poly(ether-urethane)s were prepared through a simple one-pot condensation of poly(ethylene glycol), 2,2'-dithiodiethanol, N-methyldiethanolamine, and hexamethylene diisocyanate. The sol-gel phase transition behaviors of the obtained copolymers were investigated. Experimental results showed that the aqueous medium comprising the multi-segment copolymers underwent a sol-to-gel phase transition with increasing temperature and pH. At a certain concentration, the copolymer solution could immediately change to a gel under physiological conditions (37 °C and pH 7.4), indicating their suitability as in situ injectable hydrogels in vivo. Insulin was used as a model protein drug for evaluation of the injectable hydrogels as a site-specific drug delivery system. The controlled release of insulin from the hydrogel devices was demonstrated by degradation of the copolymer, which is modulated via the 2,2'-dithiodiethanol content in the poly(ether-urethane)s. These hydrogels having multi-responsive properties may prove to be promising candidates for injectable and controllable protein drug delivery devices.

  10. Field Testing of Activated Carbon Injection Options for Mercury Control at TXU's Big Brown Station

    SciTech Connect

    John Pavlish; Jeffrey Thompson; Christopher Martin; Mark Musich; Lucinda Hamre

    2009-01-07

    The primary objective of the project was to evaluate the long-term feasibility of using activated carbon injection (ACI) options to effectively reduce mercury emissions from Texas electric generation plants in which a blend of lignite and subbituminous coal is fired. Field testing of ACI options was performed on one-quarter of Unit 2 at TXU's Big Brown Steam Electric Station. Unit 2 has a design output of 600 MW and burns a blend of 70% Texas Gulf Coast lignite and 30% subbituminous Powder River Basin coal. Big Brown employs a COHPAC configuration, i.e., high air-to-cloth baghouses following cold-side electrostatic precipitators (ESPs), for particulate control. When sorbent injection is added between the ESP and the baghouse, the combined technology is referred to as TOXECON{trademark} and is patented by the Electric Power Research Institute in the United States. Key benefits of the TOXECON configuration include better mass transfer characteristics of a fabric filter compared to an ESP for mercury capture and contamination of only a small percentage of the fly ash with AC. The field testing consisted of a baseline sampling period, a parametric screening of three sorbent injection options, and a month long test with a single mercury control technology. During the baseline sampling, native mercury removal was observed to be less than 10%. Parametric testing was conducted for three sorbent injection options: injection of standard AC alone; injection of an EERC sorbent enhancement additive, SEA4, with ACI; and injection of an EERC enhanced AC. Injection rates were determined for all of the options to achieve the minimum target of 55% mercury removal as well as for higher removals approaching 90%. Some of the higher injection rates were not sustainable because of increased differential pressure across the test baghouse module. After completion of the parametric testing, a month long test was conducted using the enhanced AC at a nominal rate of 1.5 lb/Macf. During the

  11. A harmonic injection SPWM method for the high-responsive PMSM control system

    NASA Astrophysics Data System (ADS)

    Lei, Wang; Shuanghui, Hao; Minghui, Hao; Baoyu, Song

    2016-01-01

    In a permanent magnet synchronous motor (PMSM) control system, usually, the phase voltage instruction is limited independently to prevent a three-phase pulse width modulation (PWM) wave from overflowing. This method decreases the efficiency of the bus voltage and causes voltage vector direction errors. To solve these problems, we propose a harmonic injection sinusoidal pulse-width modulation (SPWM). This method uses harmonic injected sinusoidal PWM to improve the utilisation ratio of the bus voltage, and consequently improve system performance. In this paper, we analyse the problem in terms of potential difference. The simulation results show that the proposed method can increase the utilisation ratio of the bus voltage up to 15.4%, and the voltage vector mode obtained with the proposed algorithm is larger than that obtained with the conventional one. The method with harmonic injection consequently improves current response, without affecting voltage vector accuracy. The experiment results validate the proposed method.

  12. Single Cell Transfection through Precise Microinjection with Quantitatively Controlled Injection Volumes

    PubMed Central

    Chow, Yu Ting; Chen, Shuxun; Wang, Ran; Liu, Chichi; Kong, Chi-wing; Li, Ronald A.; Cheng, Shuk Han; Sun, Dong

    2016-01-01

    Cell transfection is a technique wherein foreign genetic molecules are delivered into cells. To elucidate distinct responses during cell genetic modification, methods to achieve transfection at the single-cell level are of great value. Herein, we developed an automated micropipette-based quantitative microinjection technology that can deliver precise amounts of materials into cells. The developed microinjection system achieved precise single-cell microinjection by pre-patterning cells in an array and controlling the amount of substance delivered based on injection pressure and time. The precision of the proposed injection technique was examined by comparing the fluorescence intensities of fluorescent dye droplets with a standard concentration and water droplets with a known injection amount of the dye in oil. Injection of synthetic modified mRNA (modRNA) encoding green fluorescence proteins or a cocktail of plasmids encoding green and red fluorescence proteins into human foreskin fibroblast cells demonstrated that the resulting green fluorescence intensity or green/red fluorescence intensity ratio were well correlated with the amount of genetic material injected into the cells. Single-cell transfection via the developed microinjection technique will be of particular use in cases where cell transfection is challenging and genetically modified of selected cells are desired. PMID:27067121

  13. Controlling domain wall nucleation and injection through focussed ion beam irradiation in perpendicularly magnetized nanowires

    NASA Astrophysics Data System (ADS)

    Beguivin, A.; Petit, D. C. M. C.; Mansell, R.; Cowburn, R. P.

    2017-01-01

    Using Ga+ focussed ion beam irradiation of Ta/Pt/CoFeB/Pt perpendicularly magnetized nanowires, the nucleation and injection fields of domain walls into the nanowires is controlled. The nucleation and injection fields can be varied as a function of dose, however, the range of injection fields is found to be limited by the creation of a step in anisotropy between the irradiated and unirradiated regions. This can be altered by defocussing the beam, which allows the injection fields to be further reduced. The ability to define an arbitrary dose profile allows domain walls to be injected at different fields either side of an asymmetrically irradiated area, which could form the initial stage of a logic device. The effect of the thickness of the magnetic layer and the thickness of a Ta underlayer on the dose required to remove the perpendicular anisotropy is also studied and is seen that for similar Ta underlayers the dose is determined by the thickness of the magnetic layer rather than its anisotropy. This finding is supported by some transport of ions in matter simulations.

  14. Single Cell Transfection through Precise Microinjection with Quantitatively Controlled Injection Volumes

    NASA Astrophysics Data System (ADS)

    Chow, Yu Ting; Chen, Shuxun; Wang, Ran; Liu, Chichi; Kong, Chi-Wing; Li, Ronald A.; Cheng, Shuk Han; Sun, Dong

    2016-04-01

    Cell transfection is a technique wherein foreign genetic molecules are delivered into cells. To elucidate distinct responses during cell genetic modification, methods to achieve transfection at the single-cell level are of great value. Herein, we developed an automated micropipette-based quantitative microinjection technology that can deliver precise amounts of materials into cells. The developed microinjection system achieved precise single-cell microinjection by pre-patterning cells in an array and controlling the amount of substance delivered based on injection pressure and time. The precision of the proposed injection technique was examined by comparing the fluorescence intensities of fluorescent dye droplets with a standard concentration and water droplets with a known injection amount of the dye in oil. Injection of synthetic modified mRNA (modRNA) encoding green fluorescence proteins or a cocktail of plasmids encoding green and red fluorescence proteins into human foreskin fibroblast cells demonstrated that the resulting green fluorescence intensity or green/red fluorescence intensity ratio were well correlated with the amount of genetic material injected into the cells. Single-cell transfection via the developed microinjection technique will be of particular use in cases where cell transfection is challenging and genetically modified of selected cells are desired.

  15. Acupuncture point injection treatment of primary dysmenorrhoea: a randomised, double blind, controlled study

    PubMed Central

    Wade, C; Wang, L; Zhao, W J; Cardini, F; Kronenberg, F; Gui, S Q; Ying, Z; Zhao, N Q; Chao, M T; Yu, J

    2016-01-01

    Objective To determine if injection of vitamin K3 in an acupuncture point is optimal for the treatment of primary dysmenorrhoea, when compared with 2 other injection treatments. Setting A Menstrual Disorder Centre at a public hospital in Shanghai, China. Participants Chinese women aged 14–25 years with severe primary dysmenorrhoea for at least 6 months not relieved by any other treatment were recruited. Exclusion criteria were the use of oral contraceptives, intrauterine devices or anticoagulant drugs, pregnancy, history of abdominal surgery, participation in other therapies for pain and diagnosis of secondary dysmenorrhoea. Eighty patients with primary dysmenorrhoea, as defined on a 4-grade scale, completed the study. Two patients withdrew after randomisation. Interventions A double-blind, double-dummy, randomised controlled trial compared vitamin K3 acupuncture point injection to saline acupuncture point injection and vitamin K3 deep muscle injection. Patients in each group received 3 injections at a single treatment visit. Primary and secondary outcome measures The primary outcome was the difference in subjective perception of pain as measured by an 11 unit Numeric Rating Scale (NRS). Secondary measurements were Cox Pain Intensity and Duration scales and the consumption of analgesic tablets before and after treatment and during 6 following cycles. Results Patients in all 3 groups experienced pain relief from the injection treatments. Differences in NRS measured mean pain scores between the 2 active control groups were less than 1 unit (−0.71, CI −1.37 to −0.05) and not significant, but the differences in average scores between the treatment hypothesised to be optimal and both active control groups (1.11, CI 0.45 to 1.78) and (1.82, CI 1.45 to 2.49) were statistically significant in adjusted mixed-effects models. Menstrual distress and use of analgesics were diminished for 6 months post-treatment. Conclusions Acupuncture point injection of

  16. Lime Juice and Vinegar Injections as a Cheap and Natural Alternative to Control COTS Outbreaks

    PubMed Central

    Moutardier, Grégoire; Gereva, Sompert; Mills, Suzanne C.; Adjeroud, Mehdi; Beldade, Ricardo; Ham, Jayven; Kaku, Rocky; Dumas, Pascal

    2015-01-01

    Outbreaks of the corallivorous crown-of-thorns seastar Acanthaster planci (COTS) represent one of the greatest disturbances to coral reef ecosystems in the Indo-Pacific, affecting not only coral reefs but also the coastal communities which rely on their resources. While injection approaches are increasingly used in an attempt to control COTS densities, most of them display severe drawbacks including logistical challenges, high residual environmental impacts or low cost-effectiveness. We tested a new alternative control method based upon acidic injections of cheap, 100% natural products. We investigated the lethal doses, intra- and inter-specific disease transmission and immune responses of COTS when injected with fresh lime juice (extracted from local Citrus arantifolia) and white spirit vinegar. High COTS mortality was achieved with small volumes: 10–20 ml per seastar induced death in 89%/97% of injected specimens after an average 34.3 h/29.8 h for lime juice and vinegar respectively. Highest efficiency was reached for both solutions with double shots of (2 × 10 ml) in two different areas on the body: 100% mortality occurred within 12–24 h, which is similar or faster compared with other current injection methods. Multiple immune measures suggested that death was very likely caused by pH stress from the acidic solutions rather than a bacterial infection. Contagion to either conspecifics or a variety of other reef species was not observed, even at COTS densities 15 times higher than the highest naturally reported. 10 to 20 l lime juice/vinegar could kill up to a thousand COTS at a cost of less than 0.05 USD per specimen; no permits or special handling procedures are required. We conclude that injections of lime juice and vinegar offer great advantages when compared to current best practises and constitute a cheap and natural option for all reefs affected by COTS. PMID:26356840

  17. Lime Juice and Vinegar Injections as a Cheap and Natural Alternative to Control COTS Outbreaks.

    PubMed

    Moutardier, Grégoire; Gereva, Sompert; Mills, Suzanne C; Adjeroud, Mehdi; Beldade, Ricardo; Ham, Jayven; Kaku, Rocky; Dumas, Pascal

    2015-01-01

    Outbreaks of the corallivorous crown-of-thorns seastar Acanthaster planci (COTS) represent one of the greatest disturbances to coral reef ecosystems in the Indo-Pacific, affecting not only coral reefs but also the coastal communities which rely on their resources. While injection approaches are increasingly used in an attempt to control COTS densities, most of them display severe drawbacks including logistical challenges, high residual environmental impacts or low cost-effectiveness. We tested a new alternative control method based upon acidic injections of cheap, 100% natural products. We investigated the lethal doses, intra- and inter-specific disease transmission and immune responses of COTS when injected with fresh lime juice (extracted from local Citrus arantifolia) and white spirit vinegar. High COTS mortality was achieved with small volumes: 10-20 ml per seastar induced death in 89%/97% of injected specimens after an average 34.3 h/29.8 h for lime juice and vinegar respectively. Highest efficiency was reached for both solutions with double shots of (2 × 10 ml) in two different areas on the body: 100% mortality occurred within 12-24 h, which is similar or faster compared with other current injection methods. Multiple immune measures suggested that death was very likely caused by pH stress from the acidic solutions rather than a bacterial infection. Contagion to either conspecifics or a variety of other reef species was not observed, even at COTS densities 15 times higher than the highest naturally reported. 10 to 20 l lime juice/vinegar could kill up to a thousand COTS at a cost of less than 0.05 USD per specimen; no permits or special handling procedures are required. We conclude that injections of lime juice and vinegar offer great advantages when compared to current best practises and constitute a cheap and natural option for all reefs affected by COTS.

  18. Injection molding simulation with variothermal mold temperature control of highly filled polyphenylene sulfide

    NASA Astrophysics Data System (ADS)

    Birkholz, A.; Tschiersky, M.; Wortberg, J.

    2015-05-01

    For the installation of a fuel cell stack to convert chemical energy into electricity it is common to apply bipolar plates to separate and distribute reaction gases and cooling agents. For reducing manufacturing costs of bipolar plates a fully automated injection molding process is examined. The high performance thermoplastic matrix material, polyphenylene sulfide (PPS), defies against the chemical setting and the operation temperature up to 200 °C. To adjust also high electrical and thermal conductivity, PPS is highly filled with various carbon fillers up to an amount of 65 percentage by volume. In the first step two different structural plates (one-sided) with three different gate heights and molds are designed according to the characteristics of a bipolar plate. To cope with the approach that this plate should be producible on standard injection molding machines with variothermal mold temperature control, injection molding simulation is used. Additionally, the simulation should allow to formulate a quality prediction model, which is transferrable to bipolar plates. Obviously, the basis for a precise simulation output is an accurate description of the material properties and behavior of the highly filled compound. This, the design of the structural plate and mold and the optimization via simulation is presented, as well. The influence of the injection molding process parameters, e.g. injection time, cycle times, packing pressure, mold temperature, and melt temperature on the form filling have been simulated to determine optimal process conditions. With the aid of the simulation and the variothermal mold temperature control it was possible to reduce the required melt temperature below the decomposition temperature of PPS. Thereby, hazardous decomposition products as hydrogen sulfide are obviated. Thus, the health of the processor, the longevity of the injection molding machine as well as the material and product properties can be protected.

  19. Randomised controlled trial of local corticosteroid injections for de Quervain's tenosynovitis in general practice

    PubMed Central

    Peters-Veluthamaningal, Cyriac; Winters, Jan C; Groenier, Klaas H; Meyboom-deJong, Betty

    2009-01-01

    Background De Quervain's tenosynovitis is a stenosing tenosynovitis of the first dorsal compartment of the wrist and leads to wrist pain and to impaired function of the wrist and hand. It can be treated by splinting, local corticosteroid injection and operation. In this study effectiveness of local corticosteroid injections for de Quervain's tenosynovitis provided by general practitioners was assessed. Methods Participants with de Quervain's tenosynovitis were recruited by general practitioners. Short-term outcomes (one week after injections) were assessed in a randomised, placebo-controlled trial. Long-term effectiveness was evaluated in an open prospective cohort-study of steroid responders during a follow-up period of 12 months. Participants were randomised to one or two local injections of 1 ml of triamcinolonacetonide (TCA) or 1 ml of NaCl 0.9% (placebo). Non-responders to NaCl were treated with additional TCA injections. Main outcomes were immediate treatment response, severity of pain, improvement as perceived by participant and functional disability using sub items hand and finger function of the Dutch Arthritis Impact Measurement Scale (Dutch AIMS-2-HFF). Results 11 general practitioners included 21 wrists in 21 patients. The TCA-group had better results for short-term outcomes treatment response (78% vs. 25%; p = 0.015), perceived improvement (78% vs. 33%; p = 0.047) and severity of pain (4.27 vs. 1.33; p = 0.031) but not for the Dutch-AIMS-HFF (2.71 vs. 1.92; p = 0.112). Absolute risk reduction for the main outcome short-term treatment response was 0.55 (95% CI: 0.34, 0.76) with a number needed to treat of 2 (95% CI: 1, 3). In the cohort of steroid responders (n = 12) the beneficial effects of steroid injections were sustained during the follow-up of 12 months regarding severity of pain (p = 0.67) and scores of Dutch AIMS-2-HFF (p = 0.36), but not for patient perceived improvement (p = 0.02). No adverse events were observed during the 12 months of follow

  20. Effectiveness of intramuscular corticosteroid injection versus placebo injection in patients with hip osteoarthritis: design of a randomized double-blinded controlled trial

    PubMed Central

    2011-01-01

    Background Recent international guidelines recommend intra-articular corticosteroid injections for patients with hip osteoarthritis who have moderate to severe pain and do not respond satisfactorily to oral analgesic/anti-inflammatory agents. Of the five available randomized controlled trials, four showed positive effects with respect to pain reduction. However, intra-articular injection in the hip is complex because the joint is adjacent to important neurovascular structures and cannot be palpated. Therefore fluoroscopic or ultrasound guidance is needed. The systemic effect of corticosteroids has been studied in patients with impingement shoulder pain. Gluteal corticosteroid injection was almost as effective as ultrasound-guided subacromial corticosteroid injection. Such a clinically relevant effect of a systemic corticosteroid injection offers a less complex alternative for treatment of patients with hip osteoarthritis not responsive to oral pain medication. Methods/Design This is a double-blinded, randomized controlled trial. A total of 135 patients (aged > 40 years) with hip osteoarthritis and persistent pain despite oral analgesics visiting a general practitioner or orthopaedic surgeon will be included. They will be randomized to a gluteal intramuscular corticosteroid injection or a gluteal intramuscular placebo (saline) injection. The randomization will be stratified for setting (general practitioner and outpatient clinics of department of orthopaedics). Treatment effect will be evaluated by questionnaires at 2, 4, 6, and 12 weeks follow-up and a physical examination at 12 weeks. Primary outcome is severity of hip pain reported by the patients at 2-week follow-up. Statistical analyses will be based on the intention-to-treat principle. Discussion This study will evaluate the effectiveness of an intramuscular corticosteroid injection on pain in patients with hip osteoarthritis. Patient recruitment has started. Trial Registration This trial is registered in the

  1. Controlled CO2 injection into heterogeneous geologic formations for improved solubility and residual trapping

    NASA Astrophysics Data System (ADS)

    Shamshiri, Hossein; Jafarpour, Behnam

    2012-02-01

    Geologic CO2 storage (GCS) has been proposed as a potentially viable climate change mitigation option. Among the trapping mechanisms known for permanent CO2 storage in saline aquifers, solubility and residual trapping are important for safe short-term entrapment. These storage mechanisms are hampered by density-driven upward CO2 movement that inhibits the lateral migration of the plume, leaving a large portion of the aquifer volume unexposed to CO2 and unavailable for storage. Heterogeneity of aquifer hydraulic properties and high horizontal/vertical hydraulic conductivity ratio of geologic formations are two competing mechanisms that can hinder upward CO2 migration. Postinjection displacement of free-phase CO2 is somewhat controlled by the heterogeneity in rock permeability and porosity distributions. In particular, low permeability shale layers that act as vertical flow barrier and high-permeability horizontal channels that form flow conduits can spread the CO2 plume laterally in the aquifer. In this paper, we consider CO2 storage in heterogeneous saline aquifers and propose controlled CO2 injection, based on existing knowledge of heterogeneity, to increase CO2 contact with brine and improve the solubility and residual trapping and the overall aquifer storage potential. We examine two optimization methods: directly maximizing the total stored gas in the aquifer, and maximizing the sweep efficiency of the CO2 flood to promote uniform displacement in all directions. We consider the effect of geologic uncertainty on the performance of the controlled injection schemes by using an ensemble of model realizations to represent the uncertainty in aquifer property distribution. We also show how a controlled injection can be used to mitigate the risk of leakage from potential pathways, such as an abandoned well, by restricting CO2 movement toward the leakage zone. Our results suggest that controlled injection can lead to substantial improvements in residual and dissolution

  2. Light Control of Insulin Release and Blood Glucose Using an Injectable Photoactivated Depot

    PubMed Central

    2016-01-01

    In this work we demonstrate that blood glucose can be controlled remotely through light stimulated release of insulin from an injected cutaneous depot. Human insulin was tethered to an insoluble but injectable polymer via a linker, which was based on the light cleavable di-methoxy nitrophenyl ethyl (DMNPE) group. This material was injected into the skin of streptozotocin-treated diabetic rats. We observed insulin being released into the bloodstream after a 2 min trans-cutaneous irradiation of this site by a compact LED light source. Control animals treated with the same material, but in which light was blocked from the site, showed no release of insulin into the bloodstream. We also demonstrate that additional pulses of light from the light source result in additional pulses of insulin being absorbed into circulation. A significant reduction in blood glucose was then observed. Together, these results demonstrate the feasibility of using light to allow for the continuously variable control of insulin release. This in turn has the potential to allow for the tight control of blood glucose without the invasiveness of insulin pumps and cannulas. PMID:27653828

  3. Summary of Current and Future MSFC International Space Station Environmental Control and Life Support System Activities

    NASA Technical Reports Server (NTRS)

    Ray, Charles D.; Carrasquillo, Robyn L.; Minton-Summers, Silvia

    1997-01-01

    This paper provides a summary of current work accomplished under technical task agreement (TTA) by the Marshall Space Flight Center (MSFC) regarding the Environmental Control and Life Support System (ECLSS) as well as future planning activities in support of the International Space Station (ISS). Current activities include ECLSS computer model development, component design and development, subsystem integrated system testing, life testing, and government furnished equipment delivered to the ISS program. A long range plan for the MSFC ECLSS test facility is described whereby the current facility would be upgraded to support integrated station ECLSS operations. ECLSS technology development efforts proposed to be performed under the Advanced Engineering Technology Development (AETD) program are also discussed.

  4. Summary of Previous Chamber or Controlled Anthrax Studies and Recommendations for Possible Additional Studies

    SciTech Connect

    Piepel, Gregory F.; Amidan, Brett G.; Morrow, Jayne B.

    2010-12-29

    This report and an associated Excel file(a) summarizes the investigations and results of previous chamber and controlled studies(b) to characterize the performance of methods for collecting, storing and/or transporting, extracting, and analyzing samples from surfaces contaminated by Bacillus anthracis (BA) or related simulants. This report and the Excel are the joint work of the Pacific Northwest National Laboratory (PNNL) and the National Institute of Standards and Technology (NIST) for the Department of Homeland Security, Science and Technology Directorate. The report was originally released as PNNL-SA-69338, Rev. 0 in November 2009 with limited distribution, but was subsequently cleared for release with unlimited distribution in this Rev. 1. Only minor changes were made to Rev. 0 to yield Rev. 1. A more substantial update (including summarizing data from other studies and more condensed summary tables of data) is underway

  5. Nuclear Safety Functions of ITER Gas Injection System Instrumentation and Control and the Concept Design

    NASA Astrophysics Data System (ADS)

    Yang, Yu; Maruyama, S.; Fossen, A.; Villers, F.; Kiss, G.; Zhang, Bo; Li, Bo; Jiang, Tao; Huang, Xiangmei

    2016-08-01

    The ITER Gas Injection System (GIS) plays an important role on fueling, wall conditioning and distribution for plasma operation. Besides that, to support the safety function of ITER, GIS needs to implement three nuclear safety Instrumentation and Control (I&C) functions. In this paper, these three functions are introduced with the emphasis on their latest safety classifications. The nuclear I&C design concept is briefly discussed at the end.

  6. Independent Auditor’s Report on the FY 2014 DoD Performance Summary Report of the Funds Obligated for National Drug Control Program Activities

    DTIC Science & Technology

    2015-01-30

    Independent Auditor’s Report on the FY 2014 DoD Performance Summary Report of the Funds Obligated for National Drug Control Program Activities J A N U...Independent Auditor’s Report on the FY 2014 DoD Performance Summary Report of the Funds Obligated for National Drug Control Program Activities 5a. CONTRACT...Summary Report of the Funds Obligated for National Drug Control Program Activities (Report No. DODIG-2015-074) The Office of National Drug Control

  7. Randomised controlled trial of local corticosteroid injections for carpal tunnel syndrome in general practice

    PubMed Central

    2010-01-01

    Background Carpal tunnel syndrome is caused by entrapment of the median nerve and results in pain, tingling and numbness in the wrist and hand. It is a common condition in general practice. Effectiveness of treatment by intracarpal corticosteroid injection has never been investigated in general practice. The objective of this study was to determine if corticosteroid injections for carpal tunnel syndrome provided by general practitioners are effective. Methods In this study 69 participants with a clinical diagnosis of carpal tunnel syndrome were recruited from 20 general practices. Short-term outcomes were assessed in a randomised, placebo-controlled trial. Long-term results were assessed in a prospective cohort-study of steroid responders. Participants were randomised to intracarpal injections of 1 ml triamcinolonacetonide 10 mg/ml (TCA) or 1 ml NaCl (placebo). Non-responders to NaCl were treated with additional TCA injections. Main outcomes were immediate treatment success, mean score of the Symptom Severity Scale (SSS) and Functional Status Scale (FSS) of the Boston carpal tunnel questionnaire, subjective improvement and proportion of participants with recurrences during follow-up. Duration of follow-up was twelve months. Results The TCA-group (36 participants) had better outcomes than the NaCl-group (33 participants) during short-term assessment for outcome measures treatment response, mean improvement of SSS-score (the mean difference in change score was 0.637 {95% CI: 0.320, 0.960; p < 0.001}) and FSS-score (the mean difference in change score was 0.588 {95% CI: 0.232, 0.944; p = 0.002}) and perceived improvement (p = 0.01). The number to treat to achieve satisfactory partial treatment response or complete resolution of symptoms and signs was 3 (95% CI:1.83, 9.72). 49% of TCA-responders (17/35) had recurrences during follow-up. In the group of TCA-responders without recurrences (51%, 18/35) outcomes for SSS-score and FSS-score deteriorated during the follow

  8. Effect of semiconductor-controlled voltage injection by UPFC and ULTC on power system stability

    NASA Astrophysics Data System (ADS)

    Alavian Mehr, Alireza

    Commercial availability of various power semiconductor switches indicates proliferation of power electronic based apparatus in utility power systems. Furthermore, existing power system apparatus, e.g. mechanical phase shifters and mechanical tap changing transformers, will be retrofitted to utilize higher switching speed of semiconductor switches. A group of these apparatus, i.e., unified power flow controller (UPFC), static phase shifter (SPS), under-load tap-changing (ULTC) transformer and static series capacitor (SSC), perform their respective functions by means of injecting series controlled voltages in power systems. This thesis demonstrates that fast series voltage injection, for dynamic power flow regulation, can result in voltage dynamics and even voltage instability. This indicates that fast voltage injection by means of power electronic based apparatus can couple voltage stability and angle stability phenomena. To investigate this coupling phenomena, the voltage dependency of the load must be adequately represented in the load model. The reported studies in this work are based on representing the load by a combination of static and dynamic loads. This thesis primarily investigates impacts of UPFC and semiconductor-controlled ULTC on voltage stability and angle stability phenomena. An eigen analysis approach is used for the studies. The eigen analysis results are validated by digital time-domain simulations using a transient stability software. Both the eigen analysis and the transient stability software tools are tailored to account for angle and voltage stability phenomena.

  9. A ground based phase control system for the solar power satellite. Executive summary, volume 1, phase 3

    NASA Technical Reports Server (NTRS)

    Chie, C. M.

    1980-01-01

    The Solar Power Satellite (SPS) concept and the reference phase control system investigated in earlier efforts are reviewed. A summary overview of the analysis and selection of the pilot signal and power transponder design is presented along with the SOLARSIM program development and the simulated SPS phase control performance. Evaluations of the ground based phase control system as an alternate phase control concept are summarized.

  10. CONTROL TECHNOLOGY: SUMMARY OF THE 1991 EPRI/EPA/DOE S02 CONTROL SYMPOSIUM

    EPA Science Inventory

    The 1991 SO2 Control Symposium was held December 3–6, 1991, in Washington, D.C. The symposium, jointly sponsored by the Electric Power Research Institute (EPRI), the U.S. Environmental Protection Agency (EPA), and the U.S. Department of Energy (DOE), focused attention...

  11. Summary of the 2004 CFD Validation Workshop on Synthetic Jets and Turbulent Separation Control

    NASA Technical Reports Server (NTRS)

    Rumsey, C. L.; Gatski, T. B.; Sellers, W. L., III; Vatsa, V. N.; Viken, S. A.

    2004-01-01

    A CFD validation workshop for synthetic jets and turbulent separation control (CFDVAL2004) was held in Williamsburg, Virginia in March 2004. Three cases were investigated: synthetic jet into quiescent air, synthetic jet into a turbulent boundary layer crossflow, and flow over a hump model with no-flow-control, steady suction, and oscillatory control. This paper is a summary of the CFD results from the workshop. Although some detailed results are shown, mostly a broad viewpoint is taken, and the CFD state-of-the-art for predicting these types of flows is evaluated from a general point of view. Overall, for synthetic jets, CFD can only qualitatively predict the flow physics, but there is some uncertainty regarding how to best model the unsteady boundary conditions from the experiment consistently. As a result. there is wide variation among CFD results. For the hump flow, CFD as a whole is capable of predicting many of the particulars of this flow provided that tunnel blockage is accounted for, but the length of the separated region compared to experimental results is consistently overpredicted.

  12. Summary of the 2004 CFD Validation Workshop on Synthetic Jets and Turbulent Separation Control

    NASA Technical Reports Server (NTRS)

    Rumsey, C. L.; Gatski, T. B.; Sellers, W. L., III; Vatsa, V. N.; Viken, S. A.

    2006-01-01

    A computational fluid dynamics (CFD) validation workshop for synthetic jets and turbulent separation control (CFDVAL2004) was held in Williamsburg, Virginia in March 2004. Three cases were investigated: synthetic jet into quiescent air, synthetic jet into a turbulent boundary layer crossflow, and flow over a hump model with no-flow-control, steady suction, and oscillatory control. This paper is a summary of the CFD results from the workshop. Although some detailed results are shown, mostly a broad viewpoint is taken, and the CFD state-of-the-art for predicting these types of flows is evaluated from a general point of view. Overall, for synthetic jets, CFD can only qualitatively predict the flow physics, but there is some uncertainty regarding how to best model the unsteady boundary conditions from the experiment consistently. As a result, there is wide variation among CFD results. For the hump flow, CFD as a whole is capable of predicting many of the particulars of this flow provided that tunnel blockage is accounted for, but the length of the separated region compared to experimental results is consistently overpredicted.

  13. Corticosteroid versus placebo injection for plantar fasciitis: A meta-analysis of randomized controlled trials

    PubMed Central

    LI, ZONGHUAN; YU, AIXI; QI, BAIWEN; ZHAO, YONG; WANG, WEIYANG; LI, PING; DING, JUNHUI

    2015-01-01

    The aim of this meta-analysis was to determine the efficacy of corticosteroid versus placebo injection for the treatment of plantar fasciitis. Databases (Medline, Embase, the Cochrane Library and Google Scholar) and study references were searched for randomized controlled trials comparing corticosteroid with placebo injection for plantar fasciitis. Studies that met the inclusion criteria were selected for the analysis. The risk of bias tool was used for the methodological assessment. Outcomes including visual analogue score (VAS) and plantar fascia thickness (PFT) were extracted and pooled. Egger's test was used to detect publication bias. The evidence quality was assessed by the Grading of Recommendations Assessment, Development and Evaluation system. Statistical analysis was performed using RevMan 5.2. A total of four studies with 289 patients were included in the analysis. Compared with the placebo, corticosteroid injection provided better pain relief after one month [standardized mean difference (SMD), −0.32; 95% confidence interval (CI), −0.59--0.06); P=0.02). No difference was detected with respect to the VAS after two months (SMD, −0.04; 95% CI, −0.35–0.27; P=0.79) or three months (SMD, −0.42; 95% CI, −1.00–0.16; P=0.15) or to the PFT (MD, 0.70; 95% CI, −1.77–0.38; P=0.20), although a tendency of favoring corticosteroid injection was observed. No obvious publication bias was detected. In conclusion, corticosteroid injection may provide pain relief for a short period of time, but the efficacy may disappear with the progression of time. PMID:26136971

  14. Characterization of a high-pressure diesel fuel injection system as a control technology option to improve engine performance and reduce exhaust emissions

    NASA Technical Reports Server (NTRS)

    Mcfadden, J. J.; Dezelick, R. A.; Barrows, R. R.

    1983-01-01

    Test results from a high pressure electronically controlled fuel injection system are compared with a commercial mechanical injection system on a single cylinder, diesel test engine using an inlet boost pressure of 2.6:1. The electronic fuel injection system achieved high pressure by means of a fluid intensifier with peak injection pressures of 47 to 69 MPa. Reduced exhaust emissions were demonstrated with an increasing rate of injection followed by a fast cutoff of injection. The reduction in emissions is more responsive to the rate of injection and injection timing than to high peak injection pressure.

  15. Cavitation control on a 2D hydrofoil through a continuous tangential injection of liquid: Experimental study

    NASA Astrophysics Data System (ADS)

    Timoshevskiy, M. V.; Zapryagaev, I. I.; Pervunin, K. S.; Markovich, D. M.

    2016-10-01

    In the paper, the possibility of active control of a cavitating flow over a 2D hydrofoil that replicates a scaled-down model of high-pressure hydroturbine guide vane (GV) was tested. The flow manipulation was implemented by a continuous tangential liquid injection at different flow rates through a spanwise slot in the foil surface. In experiments, the hydrofoil was placed in the test channel at the attack angle of 9°. Different cavitation conditions were reached by varying the cavitation number and injection velocity. In order to study time dynamics and spatial patterns of partial cavities, high-speed imaging was employed. A PIV method was used to measure the mean and fluctuating velocity fields over the hydrofoil. Hydroacoustic measurements were carried out by means of a pressure transducer to identify spectral characteristics of the cavitating flow. It was found that the present control technique is able to modify the partial cavity pattern (or even totally suppress cavitation) in case of stable sheet cavitation and change the amplitude of pressure pulsations at unsteady regimes. The injection technique makes it also possible to significantly influence the spatial distributions of the mean velocity and its turbulent fluctuations over the GV section for non-cavitating flow and sheet cavitation.

  16. Electron Injection to Control Self-Assembly and Disassembly of Phenylacetylene on Gold

    NASA Astrophysics Data System (ADS)

    Baddorf, Arthur P.; Li, Qing; Han, Chengbo; Bernholc, J.; Terrones, Humberto; Sumpter, Bobby; Fuentes-Cabrera, Miguel; Yi, Jieyu; Gai, Zheng; Maksymovych, Peter; Pan, Minghu

    2013-03-01

    The power of two-dimensional organic molecular systems for applications including electronics, functionalization and nanolithography is enabled by our ability to produce structures through self-assembly on a surface. Unfortunately, relying on thermal fluctuations to drive the surface attachment reactions has limited self-assembled molecules (SAMs) to little beyond alkanethiols on gold. We demonstrate a seminal example of non-thermal control over molecular self-assembly, where hot-electron injection rather than thermal fluctuations transform a disordered layer of weakly bonded hydrocarbon molecules into an ordered, dense monolayer. The process is reversible, in that injection of holes reverts to a disordered state. Since electron and hole injection is accomplished with a STM, unprecedented local control over ordered and disordered domains is achieved. STM imaging and correlated density functional calculations reveal that ordered domains consist of molecules vertically aligned and more strongly attached to the gold substrate through the acetylene tail, while disordered domains contain weakly bound molecules lying flat. Research was conducted at the CNMS, sponsored by the Division of Scientific User Facilities, U.S. Department of Energy.

  17. Determination of dry carbon-based sorbent injection for mercury control in utility ESP and baghouses

    SciTech Connect

    Broderick, T.; Haythornthwaite, S.; Bell, W.; Selegue, T.; Perry, M.

    1998-12-31

    Domestic coal-fired power plants emit approximately 40 to 80 metric tons of mercury to the atmosphere annually. The mercury concentration in utility flue gas is in the dilute range of 0.1 to 1 parts per billion. The EPA is assessing whether such low concentrations of mercury emissions from coal-fired utilities pose any significant health risk and whether mercury regulations would be necessary or appropriate. In anticipation of possible mercury control regulations, ADA Technologies (ADA) and TDA Research, Inc (TDA) were funded by the Department of Energy (DOE) to evaluate carbon-based sorbents for mercury control at utility coal-fired power plants. Past investigations of the use of dry carbon-based sorbent injection for mercury control on pilot-scale utility flue gas applications have shown that these sorbents are capable of removing gas-phase mercury. ADA Technologies field-tested the mercury removal capability of several carbon-based sorbents manufactured by TDA. The test facility was a DOE-owned test facility built and operated by ADA at the Public Service Company of Colorado`s Comanche Station in Pueblo, Colorado. The pilot-scale test fixture is a 600-acfm particulate control module that can be configured as an electrostatic precipitator, a pulse-jet baghouse, or a reverse-gas baghouse. It extracts a slipstream of flue gas from a coal-fired utility boiler. Sorbent is injected into the flue gas slipstream upstream of the particulate control module and is removed by the module. ADA evaluated the mercury capture efficiency of the sorbents over a range of flue gas temperatures and injection rates. In addition, the effect of flyash on mercury capture was also investigated. The test facility is configured to take flue gas from either upstream or downstream of Comanche Station`s full-scale reverse-gas baghouse, allowing tests to be conducted with normal-ash or low-ash flue gas.

  18. The Louisiana Department of Natural Resources, Office of Conservation, Injection and Mining Division underground injection control program: A peer review

    SciTech Connect

    Not Available

    1989-01-01

    The reports included herein and any reports added subsequently are the result of an effort to evaluate the effectiveness of state programs to protect Underground Sources of Drinking Water (USDW) from potential contamination resulting from the operation of injection wells related to the production of oil and gas (Class II injection wells). A USDW is defined as an aquifer or its portion which supplies a public water system, or which contains sufficient water to supply a public water system, and currently supplies drinking water for human consumption, or contains a concentration of less than 10,000 mg/l total dissolved solids (TDS) and which is not otherwise exempted as a USDW. Where defined waters other than USDWs exist and where they are addressed in the state program, they are highlighted in the General Program Comments and Observations portion of the report. Readers will need to exercise care when using individual state reports to understand specific relationships between USDWs and any waters with a more limited definition. The Review Team's conclusions are in every case based on protection of USDWs. The programs examined in this study cover wells which are used for the injection of fluids into oil reservoirs for the purpose of stimulating or furthering their production when natural production mechanisms decline or cease (enhanced recovery wells) and for the disposal of waters produced in conjunction with the production of oil and gas (disposal wells).

  19. Shuttle active thermal control system development testing. Volume 1: Overall summary

    NASA Technical Reports Server (NTRS)

    Howell, H. R.

    1974-01-01

    A summary is given of a series of thermal vacuum tests designed to support the development of the orbiter active thermal control system (ATCS) and included testing of a wide heat load range modular radiator system (MRS) configured to the March 1973 orbiter baseline system, a candidate weight reducing radiator/water cooling system, and a smaller radiator system with a high performance radiator coating. The tests verified the performance of the baseline system and obtained detailed design information for application of a wide heat load range modular radiator system to the orbiter. The two candidate ATCS weight reducing designs have undergone extensive concept verification testing and their system operating characteristics have been determined in sufficient detail for application to the orbiter. Design information has been obtained for an integrated radiator/water cooling system that provides for vehicle heat rejection as well as water management of the excess fuel cell water. Processing techniques have been developed and verified for the application of a high performance thermal control coating to large radiator areas subjected to a temperature range of -280 F to +160 F.

  20. Closing plenary summary of working group 4 instrumentation and controls for ERL2011

    SciTech Connect

    Gassner, D.; Obina, T.

    2011-10-16

    Working group 4 was charged with presentations and discussions on instrumentation and controls with regards to Energy Recovery Linacs (ERL). There were 4 sessions spanning 3.5 hours in which 7 talks were delivered, the first being an invited plenary presentation. The time allotted for each talk was limited to 20-25 minutes in order to allow 5-10 minutes for discussion. Most of the talks were held in joint session with working group 5 (Unwanted Beam Loss). This format was effective for the purpose of this workshop. A final series of discussion sessions were also held with working group 5. Summary of the working group 4 activities, presented in the closing plenary session. We had a plenary presentation on operational performance, experience, and future plans at the existing ERL injector prototype at Cornell. This included instrumentation data, controls system configurations, as well as description of future needs. This was followed by four talks from KEK and RIKEN/SPring-8 that described electron beam instrumentation already in use or under development that can be applied to ERL facilities. The final talks described the ERLs under construction at KEK and BNL. The format of having joint sessions with working group 5 was beneficial as there were a significant number of common topics and concerns with regards to the causes of beam loss, instrumentation hardware, and techniques used to measure and analyze beam loss.

  1. Modeling and control of plasma rotation for NSTX using neoclassical toroidal viscosity and neutral beam injection

    SciTech Connect

    Goumiri, I. R.; Rowley, C. W.; Sabbagh, S. A.; Gates, D. A.; Gerhardt, S. P.; Boyer, M. D.; Andre, R.; Kolemen, E.; Taira, K.

    2016-02-19

    A model-based feedback system is presented to control plasma rotation in a magnetically confined toroidal fusion device, to maintain plasma stability for long-pulse operation. This research uses experimental measurements from the National Spherical Torus Experiment (NSTX) and is aimed at controlling plasma rotation using two different types of actuation: momentum from injected neutral beams and neoclassical toroidal viscosity generated by three-dimensional applied magnetic fields. Based on the data-driven model obtained, a feedback controller is designed, and predictive simulations using the TRANSP plasma transport code show that the controller is able to attain desired plasma rotation profiles given practical constraints on the actuators and the available measurements of rotation.

  2. Control of Meloidogyne chitwoodi in Potato with Shank-injected Metam Sodium and other Nematicides.

    PubMed

    Ingham, R E; Hamm, P B; Baune, M; David, N L; Wade, N M

    2007-06-01

    Metam sodium (MS) is often applied to potato fields via sprinkler irrigation systems (water-run, WR) to reduce propagules of soil-borne pathogenic fungi, particularly Verticillium dahliae, to prevent yield loss from potato early dying disease. However, this procedure has not been effective for controlling quality defects in tubers caused by Columbia root-knot nematode (Meloidogyne chitwoodi). In five trials from 1996 to 2001, application of MS by soil shank injection (SH) provided better control and tuber quality than that generally obtained by WR MS, in three of five trials. Results were similar when SH MS was injected at one (41-45 cm), two (15 and 30 cm) or three (15, 30 and 45 cm) depths. In the two trials where SH metam potassium was tested, culls were reduced to 3% and 0% and were equivalent to those resulting from a similar rate in kg a.i./ha of SH MS. A shank-injected tank mix of MS plus ethoprop EC and SH MS plus in-season chemigation applications of oxamyl provided acceptable control in trials where SH MS alone was inadequate. In-furrow application of aldicarb at planting following SH MS did not appear to increase performance. Most consistent control (0-2% culled tubers in five trials) occurred when SH MS at 280 liters/ha was used together with 1,3- dichloropropene (140 liters/ha), applied simultaneously or sequentially. This was similar to combinations of 1,3-D and WR MS, but SH MS may be preferred under certain conditions.

  3. Investigation and Demonstration of Dry Carbon-Based Sorbent Injection for Mercury Control

    SciTech Connect

    Jim Butz; Terry Hunt

    2005-11-01

    Public Service Company of Colorado and ADA Technologies, Inc. have performed a study of the injection of activated carbon for the removal of vapor-phase mercury from coal-fired flue gas streams. The project was completed under contract to the US Department of Energy's National Energy Technology Laboratory, with contributions from EPRI and Public Service Company. The prime contractor for the project was Public Service Company, with ADA Technologies as the major subcontractor providing technical support to all aspects of the project. The research and development effort was conducted in two phases. In Phase I a pilot facility was fabricated and tests were performed using dry carbon-based sorbent injection for mercury control on a coal-fired flue gas slipstream extracted from an operating power plant. Phase II was designed to move carbon injection technology towards commercial application on coal-fired power plants by addressing key reliability and operability concerns. Phase II field work included further development work with the Phase I pilot and mercury measurements on several of PSCo's coal-fired generating units. In addition, tests were run on collected sorbent plus fly ash to evaluate the impact of the activated carbon sorbent on the disposal of fly ash. An economic analysis was performed where pilot plant test data was used to develop a model to predict estimated costs of mercury removal from plants burning western coals. Testing in the pilot plant was undertaken to quantify the effects of plant configuration, flue gas temperature, and activated carbon injection rate on mercury removal. All three variables were found to significantly impact the mercury removal efficiency in the pilot. The trends were clear: mercury removal rates increased with decreasing flue gas temperature and with increasing carbon injection rates. Mercury removal was much more efficient with reverse-gas and pulse-jet baghouse configurations than with an ESP as the particulate control device

  4. Detecting Solenoid Valve Deterioration in In-Use Electronic Diesel Fuel Injection Control Systems

    PubMed Central

    Tsai, Hsun-Heng; Tseng, Chyuan-Yow

    2010-01-01

    The diesel engine is the main power source for most agricultural vehicles. The control of diesel engine emissions is an important global issue. Fuel injection control systems directly affect fuel efficiency and emissions of diesel engines. Deterioration faults, such as rack deformation, solenoid valve failure, and rack-travel sensor malfunction, are possibly in the fuel injection module of electronic diesel control (EDC) systems. Among these faults, solenoid valve failure is most likely to occur for in-use diesel engines. According to the previous studies, this failure is a result of the wear of the plunger and sleeve, based on a long period of usage, lubricant degradation, or engine overheating. Due to the difficulty in identifying solenoid valve deterioration, this study focuses on developing a sensor identification algorithm that can clearly classify the usability of the solenoid valve, without disassembling the fuel pump of an EDC system for in-use agricultural vehicles. A diagnostic algorithm is proposed, including a feedback controller, a parameter identifier, a linear variable differential transformer (LVDT) sensor, and a neural network classifier. Experimental results show that the proposed algorithm can accurately identify the usability of solenoid valves. PMID:22163597

  5. Detecting solenoid valve deterioration in in-use electronic diesel fuel injection control systems.

    PubMed

    Tsai, Hsun-Heng; Tseng, Chyuan-Yow

    2010-01-01

    The diesel engine is the main power source for most agricultural vehicles. The control of diesel engine emissions is an important global issue. Fuel injection control systems directly affect fuel efficiency and emissions of diesel engines. Deterioration faults, such as rack deformation, solenoid valve failure, and rack-travel sensor malfunction, are possibly in the fuel injection module of electronic diesel control (EDC) systems. Among these faults, solenoid valve failure is most likely to occur for in-use diesel engines. According to the previous studies, this failure is a result of the wear of the plunger and sleeve, based on a long period of usage, lubricant degradation, or engine overheating. Due to the difficulty in identifying solenoid valve deterioration, this study focuses on developing a sensor identification algorithm that can clearly classify the usability of the solenoid valve, without disassembling the fuel pump of an EDC system for in-use agricultural vehicles. A diagnostic algorithm is proposed, including a feedback controller, a parameter identifier, a linear variable differential transformer (LVDT) sensor, and a neural network classifier. Experimental results show that the proposed algorithm can accurately identify the usability of solenoid valves.

  6. Skin and needle hygiene intervention for injection drug users: Results from a randomized, controlled Stage I pilot trial

    PubMed Central

    Phillips, Kristina T.; Stein, Michael D.; Anderson, Bradley J.; Corsi, Karen F.

    2012-01-01

    A new skin and needle hygiene intervention, designed to reduce high-risk injection practices associated with bacterial and viral infections, was tested in a pilot, randomized controlled trial. Participants included 48 active heroin injectors recruited through street outreach and randomized to either the two-session intervention or an assessment-only condition (AO) and followed for six months. The primary outcome was skin and needle cleaning behavioral skills measured by videotaped demonstration. Secondary outcomes were high-risk injection practices, intramuscular injection, and bacterial infections. Intervention participants had greater improvements on the skin (d = 1.00) and needle cleaning demonstrations (d = .52) and larger reductions in high-risk injection practices (d = .32) and intramuscular injection (d = .29), with a lower incidence rate of bacterial infections (HR = .80), at 6-months compared to AO. The new intervention appears feasible and promising as a brief intervention to reduce bacterial and viral risks associated with drug injection. PMID:22341554

  7. Green Infrastructure for Stormwater Control: Gauging its Effectiveness with Community Partners, Summary of EPA GI Reports

    EPA Science Inventory

    This document is a summary of the green infrastructure reports, journal articles, and conference proceedings published to date. This summary will be updated as more reports are completed. The Environmental Protection Agency’s Office of Research and Development has an ambitious ...

  8. Controlled Electron Injection into Plasma Accelerators and SpaceCharge Estimates

    SciTech Connect

    Fubiani, Gwenael G.J.

    2005-09-01

    Plasma based accelerators are capable of producing electron sources which are ultra-compact (a few microns) and high energies (up to hundreds of MeVs) in much shorter distances than conventional accelerators. This is due to the large longitudinal electric field that can be excited without the limitation of breakdown as in RF structures.The characteristic scale length of the accelerating field is the plasma wavelength and for typical densities ranging from 1018 - 1019 cm-3, the accelerating fields and scale length can hence be on the order of 10-100GV/m and 10-40 μm, respectively. The production of quasimonoenergetic beams was recently obtained in a regime relying on self-trapping of background plasma electrons, using a single laser pulse for wakefield generation. In this dissertation, we study the controlled injection via the beating of two lasers (the pump laser pulse creating the plasma wave and a second beam being propagated in opposite direction) which induce a localized injection of background plasma electrons. The aim of this dissertation is to describe in detail the physics of optical injection using two lasers, the characteristics of the electron beams produced (the micrometer scale plasma wavelength can result in femtosecond and even attosecond bunches) as well as a concise estimate of the effects of space charge on the dynamics of an ultra-dense electron bunch with a large energy spread.

  9. Pilot scale-SO{sub 2} control by dry sodium bicarbonate injection and an electrostatic precipitator

    SciTech Connect

    Pliat, M.J.; Wilder, J.M.

    2007-10-15

    A 500 actual cubic feet gas per minute (acfm) pilot-scale SO{sub 2} control study was undertaken to investigate flue gas desulfurization (FGD) by dry sodium sorbents in 400{sup o}F (204.5{sup o}C) flue gases emitted from a coal fired boiler with flue gas concentrations between 350 and 2500 ppm SO{sub 2}. Powdered sodium alkaline reagents were injected into the hot flue gas downstream of the air preheater and the spent reagents were collected using an electrostatic precipitator. Three different sorbents were used: processed sodium bicarbonate of two particle sizes; solution mined sodium bicarbonate, and processed sodium sesquicarbonate. SO{sub 2} concentrations were measured upstream of the reagent injection, 25-ft (7.62 m) downstream of the injection point, and downstream of the electrostatic precipitator. SO{sub 2} collection efficiencies ranged from 40 to 80% using sodium bicarbonate stoichiometric ratios from 0.5 to 3.0. Much of the in-duct SO{sub 2} removal occurred during the first second of reagent reaction time, indicating that the sulfur dioxide-sodium reaction rates may be faster than have been measured for fixed bed measurements reported in the literature.

  10. Controlled laser plasma wakefield acceleration of electrons via colliding pulse injection in non-collinear geometry

    NASA Astrophysics Data System (ADS)

    Toth, Csaba; Nakamura, Kei; Geddes, Cameron; Panasenko, Dmitriy; Plateau, Guillaume; Matlis, Nicholas; Schroeder, Carl; Esarey, Eric; Leemans, Wim

    2007-11-01

    Colliding laser pulses [1] have been proposed as a method for controlling injection of electrons into a laser wakefield accelerator (LWFA) and hence producing high quality electron beams with energy spread below 1% and normalized emittances < 1 micron. The. One pulse excites a plasma wake, and a collinear pulse following behind it collides with a counterpropagating pulse forming a beat pattern that boosts background electrons into accelerating phase. A variation of the original method uses only two laser pulses [2] which may be non-collinear. The first pulse drives the wake, and beating of the trailing edge of this pulse with the colliding pulse injects electrons. Non-collinear injection avoids optical elements on the electron beam path (avoiding emittance growth). We report on progress of non-collinear experiments at LBNL, using the Ti:Sapphire laser at the LOASIS facility of LBNL. New results indicate that the electron beam properties are affected by the presence of the second beam. [1] E. Esarey, et al, Phys. Rev. Lett 79, 2682 (1997) [2] G. Fubiani, Phys. Rev. E 70, 016402 (2004)

  11. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.

    2009-01-01

    This article presents summaries of three recent crisis management publications: (1) "School Violence: Associations With Control, Security/Enforcement, Educational/Therapeutic Approaches, and Demographic Factors," reviewed by Ashlee Barton; (2) "The Relationship Between Cognitive Coping Styles and PTSD in Survivors of Traffic Accidents," summarized…

  12. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.

    2009-01-01

    This article presents summaries of two recent crisis management publications: (1) "Social Validity of the CISM Model for School Crisis Intervention," summarized by Jack R. Dempsey; and (2) "School Violence: Associations With Control, Security/Enforcement, Educational/Therapeutic Approaches, and Demographic Factors," summarized by Ashlee Barton.…

  13. A summary of the new GINA strategy: a roadmap to asthma control.

    PubMed

    Reddel, Helen K; Bateman, Eric D; Becker, Allan; Boulet, Louis-Philippe; Cruz, Alvaro A; Drazen, Jeffrey M; Haahtela, Tari; Hurd, Suzanne S; Inoue, Hiromasa; de Jongste, Johan C; Lemanske, Robert F; Levy, Mark L; O'Byrne, Paul M; Paggiaro, Pierluigi; Pedersen, Soren E; Pizzichini, Emilio; Soto-Quiroz, Manuel; Szefler, Stanley J; Wong, Gary W K; FitzGerald, J Mark

    2015-09-01

    Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and annually updated a global strategy for asthma management and prevention that has formed the basis for many national guidelines. However, uptake of existing guidelines is poor. A major revision of the GINA report was published in 2014, and updated in 2015, reflecting an evolving understanding of heterogeneous airways disease, a broader evidence base, increasing interest in targeted treatment, and evidence about effective implementation approaches. During development of the report, the clinical utility of recommendations and strategies for their practical implementation were considered in parallel with the scientific evidence.This article provides a summary of key changes in the GINA report, and their rationale. The changes include a revised asthma definition; tools for assessing symptom control and risk factors for adverse outcomes; expanded indications for inhaled corticosteroid therapy; a framework for targeted treatment based on phenotype, modifiable risk factors, patient preference, and practical issues; optimisation of medication effectiveness by addressing inhaler technique and adherence; revised recommendations about written asthma action plans; diagnosis and initial treatment of the asthma-chronic obstructive pulmonary disease overlap syndrome; diagnosis in wheezing pre-school children; and updated strategies for adaptation and implementation of GINA recommendations.

  14. Controlled, sustained release of proteins via an injectable, mineral-coated microsphere delivery vehicle

    NASA Astrophysics Data System (ADS)

    Franklin-Ford, Travelle

    Hydroxyapatite interfaces have demonstrated strong protein binding and protein selection from a passing solution and can serve as a biocompatible carrier for controlled protein delivery. Hydroxyapatite is a major component of long bones and tooth enamel and is the most stable of all calcium phosphate isoforms in aqueous solutions at physiologic pH, providing a sensitive chromatographic mechanism for separating proteins. Here we describe an approach to create a synthetic hydroxyapatite coating through a biomimetic, heterogeneous nucleation from a modified simulated body fluid--supersaturated with calcium and phosphate ions on the surface of injectable polymer microspheres. We are able to bind and release bioactive growth factors into a variety of in vitro and in vivo conditions, demonstrating the functionality and advantage of the biomaterial. Creating a hydroxyapatite layer on the Poly(D,L-lactide-co-glycolide) (PLG) microsphere surface, avails the microsphere interior for another application that will not compete with protein binding and release. Encapsulating an imaging agent within the aqueous phase of the emulsion provides a visual reference for the injectable therapy upon microsphere fabrication. Another advantage of this system is that the mineral coating and subsequent protein binding is not compromised by the encapsulated imaging agent. This dual function delivery vehicle is not only advantageous for spatial tracking therapeutic applications, but also determining the longevity of the delivery vehicle once injected. In the broader sense, providing a mechanism to image and track our temporally controlled, sustained delivery system gives more evidence to support the effects of released protein on in vivo responses (bioactivity) and locate microspheres within different biological systems.

  15. Electronically controlled distributor type fuel injection pump for internal combustion engines

    SciTech Connect

    Kobayashi, T.; Nozaki, S.; Yamada, K.

    1986-08-12

    A distributor type fuel injection pump is described for an internal combustion engine, comprising: a suction space filled with fuel under pressure variable as a function of the rotational speed of the engine; a plunger driven by the engine for concurrent reciprocating and rotative motion to effect suction of fuel from the suction space into a pump working chamber defined by the plunger at one end thereof, pressure delivery of fuel from the pump working chamber and distribution of the fuel into cylinders of the engine; suction ports formed in the plunger and identical in number with the cylinders of the engine. The suction ports with the pump working chamber; a first communication passageway communicating the suction space with the pump working chamber; a second communication passageway having a restriction therein. The second communication passageway is disposed to sequentially register with the suction ports as the plunger rotates for communicating the suction space with each of the suction ports that registers with the second communication passageway; a solenoid valve disposed to selectively open and close the first communication passageway; a selector valve operable to assume, independently of the opening and closing action of the solenoid valve, a first valve position wherein the first communication passageway is closed and simultaneously the second communication passageway is opened, at the start of the engine, and a second valve position wherein the second communication passageway is closed and simultaneously the first communication passageway is is opened, during operation of the engine other than at the start of the engine; and control means operable in response to operating conditions of the engine to control the solenoid valve to alternately open and close so as to achieve required fuel injection quantity and required injection timing.

  16. CO2 Injection Into CH4 Hydrate Reservoirs: Quantifying Controls of Micro-Scale Processes

    NASA Astrophysics Data System (ADS)

    Bigalke, N. K.; Deusner, C.; Kossel, E.; Haeckel, M.

    2014-12-01

    The exchangeability of methane for carbon dioxide in gas hydrates opens the possibility of producing emission-neutral hydrocarbon energy. Recent field tests have shown that the production of natural gas from gas hydrates is feasible via injection of carbon dioxide into sandy, methane-hydrate-bearing sediment strata. Industrial-scale application of this method requires identification of thermo- and fluid-dynamic as well as kinetic controls on methane yield from and carbon dioxide retention within the reservoir. Extraction of gas via injection of carbon dioxide into the hydrate reservoir triggers a number of macroscopic effects, which are revealed for example by changes of the hydraulic conductivity and geomechanical stability. Thus far, due to analytical limitations, localized reactions and fluid-flow phenomena held responsible for these effects remain unresolved on the microscale (1 µm - 1 mm) and at near-natural reservoir conditions. We address this deficit by showing results from high-resolution, two-dimensional Raman spectroscopy mappings of an artificial hydrate reservoir during carbon dioxide injection under realistic reservoir conditions. The experiments allow us to resolve hydrate conversion rate and efficiency as well as activation of fluid pathways in space and time and their effect on methane yield, carbon-dioxide retention and hydraulic conductivity of the reservoir. We hypothesize that the conversion of single hydrate grains is a diffusion-controlled process which starts at the grain surface before continuing into the grain interior and show that the conversion can be modeled simply by using published permeation coefficients for CO2 and CH4 in hydrate and grain size as only input parameters.

  17. Curative and Residual Efficacy of Injection Applications of Avermectins for Control of Plant-parasitic Nematodes on Banana

    PubMed Central

    Jansson, Richard K.; Rabatin, Susan

    1997-01-01

    Studies were conducted to determine the curative and residual efficacy of avermectins at controlling plant-parasitic nematodes when injected into the pseudostem of banana, Musa acuminata cv. Cavendish. In addition, we determined the lowest concentration of avermectins that provided satisfactory efficacy as protectants when injected into banana pseudostems. Experiments were conducted with a root-knot nematode, Meleidogyne javanica, and the burrowing nematode, Radopholus similis. Injections (1 ml) of ≥ 100 μg a.i./plant of abamectin into pseudostems were effective at controlling M. javanica and R. similis, and were comparable to control achieved with a conventional chemical nemaficide, fenamiphos, in a protectant assay. Abamecfin injections of 250 and 500 μg a.i./plant were effective at reducing nematode infections 28 to 56 days after inoculation. Abamectin was more effective than ivermectin at controlling nematodes after nematode populations were established in banana roots. Injections of between 100 and 1,000 μg a.i./plant were effective at controlling nematodes for at least 56 days after treatment. These studies confirmed earlier results and demonstrated that abamecfin has potential for controlling nematode parasites on banana when injected into the pseudostem. PMID:19274271

  18. Curative and Residual Efficacy of Injection Applications of Avermectins for Control of Plant-parasitic Nematodes on Banana.

    PubMed

    Jansson, R K; Rabatin, S

    1997-12-01

    Studies were conducted to determine the curative and residual efficacy of avermectins at controlling plant-parasitic nematodes when injected into the pseudostem of banana, Musa acuminata cv. Cavendish. In addition, we determined the lowest concentration of avermectins that provided satisfactory efficacy as protectants when injected into banana pseudostems. Experiments were conducted with a root-knot nematode, Meleidogyne javanica, and the burrowing nematode, Radopholus similis. Injections (1 ml) of >/= 100 mug a.i./plant of abamectin into pseudostems were effective at controlling M. javanica and R. similis, and were comparable to control achieved with a conventional chemical nemaficide, fenamiphos, in a protectant assay. Abamecfin injections of 250 and 500 mug a.i./plant were effective at reducing nematode infections 28 to 56 days after inoculation. Abamectin was more effective than ivermectin at controlling nematodes after nematode populations were established in banana roots. Injections of between 100 and 1,000 mug a.i./plant were effective at controlling nematodes for at least 56 days after treatment. These studies confirmed earlier results and demonstrated that abamecfin has potential for controlling nematode parasites on banana when injected into the pseudostem.

  19. Integrated computer control system CORBA-based simulator FY98 LDRD project final summary report

    SciTech Connect

    Bryant, R M; Holloway, F W; Van Arsdall, P J

    1999-01-15

    The CORBA-based Simulator was a Laboratory Directed Research and Development (LDRD) project that applied simulation techniques to explore critical questions about distributed control architecture. The simulator project used a three-prong approach comprised of a study of object-oriented distribution tools, computer network modeling, and simulation of key control system scenarios. This summary report highlights the findings of the team and provides the architectural context of the study. For the last several years LLNL has been developing the Integrated Computer Control System (ICCS), which is an abstract object-oriented software framework for constructing distributed systems. The framework is capable of implementing large event-driven control systems for mission-critical facilities such as the National Ignition Facility (NIF). Tools developed in this project were applied to the NIF example architecture in order to gain experience with a complex system and derive immediate benefits from this LDRD. The ICCS integrates data acquisition and control hardware with a supervisory system, and reduces the amount of new coding and testing necessary by providing prebuilt components that can be reused and extended to accommodate specific additional requirements. The framework integrates control point hardware with a supervisory system by providing the services needed for distributed control such as database persistence, system start-up and configuration, graphical user interface, status monitoring, event logging, scripting language, alert management, and access control. The design is interoperable among computers of different kinds and provides plug-in software connections by leveraging a common object request brokering architecture (CORBA) to transparently distribute software objects across the network of computers. Because object broker distribution applied to control systems is relatively new and its inherent performance is roughly threefold less than traditional point

  20. INVESTIGATION AND DEMONSTRATION OF DRY CARBON-BASED SORBENT INJECTION FOR MERCURY CONTROL

    SciTech Connect

    Terry Hunt; Mark Fox; Lillian Stan; Sheila Haythornthwaite; Justin Smith; Jason Ruhl

    1998-10-01

    This quarterly report describes the activities that have taken place during the first full quarter of the Phase II project ''Investigation and Demonstration of Dry Carbon-Based Sorbent Injection for Mercury Control''. Modifications were completed and sampling began at the 600 acfm pilot-scale particulate control module (PCM) located at the Comanche Station in Pueblo, CO. The PCM was configured as an electrostatic precipitator for these tests. A Perkin-Elmer flue gas mercury analyzer was installed on-site and operated. Initial test results using both manual sampling methodology and the mercury analyzer are presented herein. Preparations were made during this period for full-scale mercury testing of several PSCo units. A site visit was made to Arapahoe and Cherokee Generating Stations to determine sample locations and to develop a test plan.

  1. Controlled Betatron X-Ray Radiation from Tunable Optically Injected Electrons

    SciTech Connect

    Corde, S.; Phuoc, K. Ta; Fitour, R.; Faure, J.; Tafzi, A.; Goddet, J. P.; Malka, V.; Rousse, A.

    2011-12-16

    The features of Betatron x-ray emission produced in a laser-plasma accelerator are closely linked to the properties of the relativistic electrons which are at the origin of the radiation. While in interaction regimes explored previously the source was by nature unstable, following the fluctuations of the electron beam, we demonstrate in this Letter the possibility to generate x-ray Betatron radiation with controlled and reproducible features, allowing fine studies of its properties. To do so, Betatron radiation is produced using monoenergetic electrons with tunable energies from a laser-plasma accelerator with colliding pulse injection [J. Faure et al., Nature (London) 444, 737 (2006)]. The presented study provides evidence of the correlations between electrons and x-rays, and the obtained results open significant perspectives toward the production of a stable and controlled femtosecond Betatron x-ray source in the keV range.

  2. Controlled betatron x-ray radiation from tunable optically injected electrons.

    PubMed

    Corde, S; Phuoc, K Ta; Fitour, R; Faure, J; Tafzi, A; Goddet, J P; Malka, V; Rousse, A

    2011-12-16

    The features of Betatron x-ray emission produced in a laser-plasma accelerator are closely linked to the properties of the relativistic electrons which are at the origin of the radiation. While in interaction regimes explored previously the source was by nature unstable, following the fluctuations of the electron beam, we demonstrate in this Letter the possibility to generate x-ray Betatron radiation with controlled and reproducible features, allowing fine studies of its properties. To do so, Betatron radiation is produced using monoenergetic electrons with tunable energies from a laser-plasma accelerator with colliding pulse injection [J. Faure et al., Nature (London) 444, 737 (2006)]. The presented study provides evidence of the correlations between electrons and x-rays, and the obtained results open significant perspectives toward the production of a stable and controlled femtosecond Betatron x-ray source in the keV range.

  3. Liposomal bupivacaine versus traditional periarticular injection for pain control after total knee arthroplasty.

    PubMed

    Bagsby, Deren T; Ireland, Phillip H; Meneghini, R Michael

    2014-08-01

    The purpose of this study was to compare a novel liposomal bupivacaine to traditional peri-articular injection (PAI) in a multi-modal pain protocol for total knee arthroplasty (TKA). A retrospective cohort study compared 85 consecutive patients undergoing TKA with a traditional PAI of ropivacaine, epinephrine and morphine to 65 patients with a liposomal bupivacaine PAI. After the initial 24h, inpatient self-reported pain scores were higher in the liposomal bupivacaine group compared to the traditional PAI group (P = 0.04) and a smaller percentage (16.9%) of patients in the liposomal bupivacaine group rated their pain as "mild" compared to the traditional group (47.6%). Liposomal bupivacaine PAI provided inferior pain control compared to the less expensive traditional PAI in a multi-modal pain control program in patients undergoing TKA.

  4. Two-Year Follow-Up Results of Fluoroscopic Cervical Epidural Injections in Chronic Axial or Discogenic Neck Pain: A Randomized, Double-Blind, Controlled Trial

    PubMed Central

    Manchikanti, Laxmaiah; Cash, Kimberly A.; Pampati, Vidyasagar; Malla, Yogesh

    2014-01-01

    Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain. Methods: One hundred and twenty patients without disc herniation or radiculitis and negative for facet joint pain as determined by means of controlled diagnostic medial branch blocks were randomly assigned to one of the 2 treatment groups. Group I patients received cervical interlaminar epidural injections of local anesthetic (lidocaine 0.5%, 5 mL), whereas Group II patients received 0.5% lidocaine, 4 mL, mixed with 1 mL or 6 mg of nonparticulate betamethasone. The primary outcome measure was ≥ 50% improvement in pain and function. Outcome assessments included numeric rating scale (NRS), Neck Disability Index (NDI), opioid intake, employment, and changes in weight. Results: Significant pain relief and functional improvement (≥ 50%) was present at the end of 2 years in 73% of patients receiving local anesthetic only and 70% receiving local anesthetic with steroids. In the successful group of patients, however, defined as consistent relief with 2 initial injections of at least 3 weeks, significant improvement was illustrated in 78% in the local anesthetic group and 75% in the local anesthetic with steroid group at the end of 2 years. The results reported at the one-year follow

  5. Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial.

    PubMed

    Ayatollahi, Vida; Behdad, Shekoufeh; Kargar, Saeed; Yavari, Tayebe

    2012-01-01

    Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect. One of most popular complication in using this drug is pain during injection that is more sever in new generation of its components (lipid-free microemulsion). Other complications of propofol are bradycardia and hypotension. This study compares 3 drugs with placebo in control of these complications of propofol. In this double blinded randomized placebo controlled trial 140 patient who were candidates for elective surgery were divided in 4 groups (35 patients in each groups) and drugs (ephedrine, lidocaine, ketamine and NaCl solution (as placebo) were tried on each group by a blinded technician and responses to drugs were evaluated under supervision of a blinded anesthesiologist. Pain after injection, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were measured 5 times during anesthesia process of each patient. All gathered data were analyzed using t-test and Chi-square under SPSS software. Our data shows that in pain management all tested drugs can decrease pain significantly comparing with placebo (P=0.017). In control of hemodynamic parameters ephedrine could efficiently control SBP, DBP, MAP at the time 1 min after intubation. Based on our study ephedrine can be an appropriate suggestion for control of both pain and hemodynamic changes induced by propofol, although because of inconsistent result in other studies it is recommended to design a systematic review to draw a broader view on this issue.

  6. [Experiences with pain control during piglet castration in Switzerland Part 2: Injection anesthesia].

    PubMed

    Enz, A; Schüpbach-Regula, G; Bettschart, R; Fuschini, E; Bürgi, E; Sidler, X

    2013-12-01

    The aim of this study was to describe the practical implementation of the painless castration under injection anaesthesia in Switzerland. 30 swine farms were visited and 60 farmers answered a questionnaire. 34 % of the piglets showed movements during castration under injection anaesthesia and 17 % had excitations during recovery from anaesthesia. After 48 minutes half of the piglets were in sternal position and after 112 minutes half of them showed coordinated movements. The body temperature decreased by 3.1 °C until 60 minutes after castration, especially small piglets reached critical temperature levels. 38 % of the piglets showed strong bleeding after castration. The healing of the wound was good according to 82 % of the farmers. 83 % of the farmers reported piglet losses, especially at the beginning of the anaesthesia period. The anaesthesia may be improved by using butorphanol in addition to the combination of ketamine and azaperone. The recovery of the piglets should be in a warm place without any risk of injury by obstacles or the sow. Increased bleeding can be controlled by using an emasculator.

  7. FUEL FORMULATION EFFECTS ON DIESEL FUEL INJECTION, COMBUSTION, EMISSIONS AND EMISSION CONTROL

    SciTech Connect

    Boehman, A; Alam, M; Song, J; Acharya, R; Szybist, J; Zello, V; Miller, K

    2003-08-24

    This paper describes work under a U.S. DOE sponsored Ultra Clean Fuels project entitled ''Ultra Clean Fuels from Natural Gas,'' Cooperative Agreement No. DE-FC26-01NT41098. In this study we have examined the incremental benefits of moving from low sulfur diesel fuel and ultra low sulfur diesel fuel to an ultra clean fuel, Fischer-Tropsch diesel fuel produced from natural gas. Blending with biodiesel, B100, was also considered. The impact of fuel formulation on fuel injection timing, bulk modulus of compressibility, in-cylinder combustion processes, gaseous and particulate emissions, DPF regeneration temperature and urea-SCR NOx control has been examined. The primary test engine is a 5.9L Cummins ISB, which has been instrumented for in-cylinder combustion analysis and in-cylinder visualization with an engine videoscope. A single-cylinder engine has also been used to examine in detail the impacts of fuel formulation on injection timing in a pump-line-nozzle fueling system, to assist in the interpretation of results from the ISB engine.

  8. Fuel injection pump having a compact spill-port timing control unit

    SciTech Connect

    Matsumura, T.; Miyaki, M.; Masuda, A.

    1986-03-04

    This patent describes a fuel injection pump. This pump consists of a compression chamber adapted to be coupled to a source of fuel; fuel injection nozzles; a rotary plunger rotatably driven by an internal combustion engine, the plunger including means for defining a common passageway connected at one end to the compression chamber, the plunger further including means for defining angularly spaced apart spill ports branching off the common passageway to an outside surface thereof and a fuel delivery port branching off the common passageway, the fuel delivery port being selectively movable into and out of alignment with each one of the nozzles by rotation of the plunger; a magnetized rotary ring including means for defining a spill groove extending along the inner wall thereof, the ring being mounted on the plunger and rotatable, with respect to the plunger, between at least a first angular position, the ring consists of a cylindrical structure having differently magnetized equally divided arcuate sections, the groove being formed on the inner wall of the cylindrical structure and substantially axially extending from one end of the structure; spring means for biasing the ring toward one of the first and second angular positions; a stationary core surrounding the ring; and a coil wound on the core for generating a rotative thrust on the ring for selectively moving the ring between the first and second angular positions in response to a control signal.

  9. Controlled infection of Poecilia reticulata Peters (guppy) with Tetrahymena by immersion and intraperitoneal injection.

    PubMed

    Sharon, G; Pimenta-Leibowitz, M; Vilchis, M C L; Isakov, N; Zilberg, D

    2015-01-01

    Tetrahymena is a protozoan parasite, which infects guppy, Poecilia reticulata Peters, and causes substantial economical losses in commercial farms worldwide. Studies of guppy infected by Tetrahymena require standardized infection protocols. The LD50 for Tetrahymena infection of guppies by intraperitoneal (IP) injection was calibrated, and the level obtained was 946 parasites per fish. Guppy infection with Tetrahymena by immersion, imitating the natural route of infection via the integument, was studied under normal or stress conditions. Exposure to cold and netting (CNI) and to cold only (CI) followed by immersion exposure to 10 000 Tetrahymena per mL resulted in 22.5% and 19.2% mortality, respectively, as compared to 14.2% and 10% in groups that were netted only (NI) or non-stressed (I). Histopathology revealed that immersion infection resulted in a systemic infection. Lysozyme levels, measured 3 weeks after infection, were significantly higher in the CNI group (288 μg per mg protein) compared with CI-, NI- and I-treated groups (94.5, 64 and 62.3 μg mg(-1), respectively). There was no evident parasite immobilization activity in body homogenates, suggesting no development of acquired immunity. Re-infection by IP injection revealed no increase in protection in any of the treatment groups, mortality range of 56.3-75%, higher than in the non-exposed control (40.6% mortality).

  10. Sulfate geoengineering: a review of the factors controlling the needed injection of sulfur dioxide

    NASA Astrophysics Data System (ADS)

    Visioni, Daniele; Pitari, Giovanni; Aquila, Valentina

    2017-03-01

    Sulfate geoengineering has been proposed as an affordable and climate-effective means to temporarily offset the warming produced by the increase of well-mixed greenhouse gases (WMGHGs). This technique would likely have to be applied while and after global intergovernmental measures on emissions of WMGHGs are implemented in order to achieve surface temperature stabilization. The direct radiative effects of sulfur injection in the tropical lower stratosphere can be summarized as increasing shortwave scattering with consequent tropospheric cooling and increasing longwave absorption with stratospheric warming. Indirect radiative effects are related to induced changes in the ozone distribution; stratospheric water vapor abundance,;formation and size of upper-tropospheric cirrus ice particles; and lifetime of long-lived species, namely CH4 in connection with OH changes through several photochemical mechanisms. Direct and indirect effects of sulfate geoengineering both concur to determine the atmospheric response. A review of previous studies on these effects is presented here, with an outline of the important factors that control the amount of sulfur dioxide to be injected in an eventual realization of the experiment. However, we need to take into account that atmospheric models used for these studies have shown a wide range of climate sensitivity and differences in the response to stratospheric volcanic aerosols. In addition, large uncertainties exist in the estimate of some of these aerosol effects.

  11. Coal-water slurry spray characteristics of an electronically-controlled accumulator fuel injection system

    SciTech Connect

    Caton, J.A.; Payne, S.E.; Terracina, D.P.; Kihm, K.D.

    1993-12-31

    Experiments have been complete to characterize coal-water slurry sprays from a electronically-controlled accumulator fuel injection system of diesel engine. The sprays were injected into a pressurized chamber equipped with windows. High speed movies, fuel pressures and needle lifts were obtained as a function of time, orifice diameter, coal loading, gas density in the chamber, and accumulator fuel pressure. For the base conditions 50% (by mass) coal loading, 0.4 mm diameter nozzle hole, coal-water slurry pressure of 82 MPa (12,000 psi), and a chamber density of 25 kg/m{sup 3}, the break-up time was 0. 30 ms. An empirical correlation for both spray tip penetration and initial jet velocity was developed. For the conditions of this study, the spray tip penetration and initial jet velocity were 15% greater for coal-water slurry than for diesel fuel or water. Cone angles of the sprays were dependent on the operating conditions and fluid, as well as the time and locations of the measurement. The time-averaged cone angle for the base case conditions was 13.6{degree}. Results of this study and the correlation are specific to the tested coal-water slurry and are not general for other coal-water slurry fuels.

  12. Thrust shock vector control of an axisymmetric conical supersonic nozzle via secondary transverse gas injection

    NASA Astrophysics Data System (ADS)

    Zmijanovic, V.; Lago, V.; Sellam, M.; Chpoun, A.

    2014-01-01

    Transverse secondary gas injection into the supersonic flow of an axisymmetric convergent-divergent nozzle is investigated to describe the effects of the fluidic thrust vectoring within the framework of a small satellite launcher. Cold-flow dry-air experiments are performed in a supersonic wind tunnel using two identical supersonic conical nozzles with the different transverse injection port positions. The complex three-dimensional flow field generated by the supersonic cross-flows in these test nozzles was examined. Valuable experimental data were confronted and compared with the results obtained from the numerical simulations. Different nozzle models are numerically simulated under experimental conditions and then further investigated to determine which parameters significantly affect thrust vectoring. Effects which characterize the nozzle and thrust vectoring performances are established. The results indicate that with moderate secondary to primary mass flow rate ratios, ranging around 5 %, it is possible to achieve pertinent vector side forces. It is also revealed that injector positioning and geometry have a strong effect on the shock vector control system and nozzle performances.

  13. Lacosamide Injection

    MedlinePlus

    ... with other medications to control certain types of seizures in people who cannot take oral medications. Lacosamide ... If you suddenly stop using lacosamide injection, your seizures may happen more often. Your doctor will probably ...

  14. Doxercalciferol Injection

    MedlinePlus

    Doxercalciferol injection is used to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone [PTH; a natural substance needed to control the amount of calcium in ...

  15. Haloperidol Injection

    MedlinePlus

    ... emotions). Haloperidol injection is also used to control motor tics (uncontrollable need to repeat certain body movements) ... people who have Tourette's disorder (condition characterized by motor or verbal tics). Haloperidol is in a class ...

  16. Late - Cycle Injection of Air/Oxygen - Enriched Air for Diesel Exhaust Emissions Control

    SciTech Connect

    Mather, Daniel

    2000-08-20

    Reduce the ''Engine Out'' particulates using the ''In Cylinder'' technique of late cycle auxiliary gas injection (AGI). Reduce the ''Engine Out'' NOx by combining AGI with optimization of fuel injection parameters. Maintain or Improve the Fuel Efficiency.

  17. Coherent control of injection currents in high-quality films of Bi{sub 2}Se{sub 3}

    SciTech Connect

    Bas, D. A.; Vargas-Velez, K.; Babakiray, S.; Johnson, T. A.; Borisov, P.; Stanescu, T. D.; Lederman, D.; Bristow, A. D.

    2015-01-26

    Films of the topological insulator Bi{sub 2}Se{sub 3} are grown by molecular beam epitaxy with in-situ reflection high-energy electron diffraction. The films are shown to be high-quality by X-ray reflectivity and diffraction and atomic-force microscopy. Quantum interference control of photocurrents is observed by excitation with harmonically related pulses and detected by terahertz radiation. The injection current obeys the expected excitation irradiance dependence, showing linear dependence on the fundamental pulse irradiance and square-root irradiance dependence of the frequency-doubled optical pulses. The injection current also follows a sinusoidal relative-phase dependence between the two excitation pulses. These results confirm the third-order nonlinear optical origins of the coherently controlled injection current. Experiments are compared to a tight-binding band structure to illustrate the possible optical transitions that occur in creating the injection current.

  18. Application of knowledge-based vision to closed-loop control of the injection molding process

    NASA Astrophysics Data System (ADS)

    Marsh, Robert; Stamp, R. J.; Hill, T. M.

    1997-10-01

    An investigation is under way to develop a control system for an industrial process which uses a vision systems as a sensor. The research is aimed at the improvement of product quality in commercial injection molding system. A significant enhancement has been achieved in the level of application of visually based inspection techniques to component quality. The aim of the research has been the investigation, and employment, of inspection methods that use knowledge based machine vision. The application of such techniques in this context is comprehensive, extending from object oriented analysis, design and programming of the inspection program, to the application of rule based reasoning, to image interpretation, vision system diagnostics, component diagnostics and molding machine control. In this way, knowledge handling methods are exploited wherever they prove to be beneficial. The vision knowledge base contains information on the procedures required to achieve successful identification of component surface defects. A collection of image processing and pattern recognition algorithms are applied selectively. Once inspection of the component has been performed, defects are related to process variables which affect the quality of the component, and another knowledge base is used to effect a control action at the molding machine. Feedback from other machine sensor is also used to direct the control procedure. Results from the knowledge based vision inspection system are encouraging. They indicate that rapid and effective fault detection and analysis is feasible, as is the verification of system integrity.

  19. A Design Methodology for Rapid Implementation of Active Control Systems Across Lean Direct Injection Combustor Platforms

    NASA Technical Reports Server (NTRS)

    Baumann, William T.; Saunders, William R.; Vandsburger, Uri; Saus, Joseph (Technical Monitor)

    2003-01-01

    The VACCG team is comprised of engineers at Virginia Tech who specialize in the subject areas of combustion physics, chemical kinetics, dynamics and controls, and signal processing. Currently, the team's work on this NRA research grant is designed to determine key factors that influence combustion control performance through a blend of theoretical and experimental investigations targeting design and demonstration of active control for three different combustors. To validiate the accuracy of conclusions about control effectiveness, a sequence of experimental verifications on increasingly complex lean, direct injection combustors is underway. During the work period January 1, 2002 through October 15, 2002, work has focused on two different laboratory-scale combustors that allow access for a wide variety of measurements. As the grant work proceeds, one key goal will be to obtain certain knowledge about a particular combustor process using a minimum of sophisticated measurements, due to the practical limitations of measurements on full-scale combustors. In the second year, results obtained in the first year will be validated on test combustors to be identified in the first quarter of that year. In the third year, it is proposed to validate the results at more realistic pressure and power levels by utilizing the facilities at the Glenn Research Center.

  20. Precision vector control of a superconducting RF cavity driven by an injection locked magnetron

    DOE PAGES

    Chase, Brian; Pasquinelli, Ralph; Cullerton, Ed; ...

    2015-03-01

    The technique presented in this paper enables the regulation of both radio frequency amplitude and phase in narrow band devices such as a Superconducting RF (SRF) cavity driven by constant power output devices i.e. magnetrons [1]. The ability to use low cost high efficiency magnetrons for accelerator RF power systems, with tight vector regulation, presents a substantial cost savings in both construction and operating costs - compared to current RF power system technology. An operating CW system at 2.45 GHz has been experimentally developed. Vector control of an injection locked magnetron has been extensively tested and characterized with a SRFmore » cavity as the load. Amplitude dynamic range of 30 dB, amplitude stability of 0.3% r.m.s, and phase stability of 0.26 degrees r.m.s. has been demonstrated.« less

  1. Precision vector control of a superconducting RF cavity driven by an injection locked magnetron

    SciTech Connect

    Chase, Brian; Pasquinelli, Ralph; Cullerton, Ed; Varghese, Philip

    2015-03-01

    The technique presented in this paper enables the regulation of both radio frequency amplitude and phase in narrow band devices such as a Superconducting RF (SRF) cavity driven by constant power output devices i.e. magnetrons [1]. The ability to use low cost high efficiency magnetrons for accelerator RF power systems, with tight vector regulation, presents a substantial cost savings in both construction and operating costs - compared to current RF power system technology. An operating CW system at 2.45 GHz has been experimentally developed. Vector control of an injection locked magnetron has been extensively tested and characterized with a SRF cavity as the load. Amplitude dynamic range of 30 dB, amplitude stability of 0.3% r.m.s, and phase stability of 0.26 degrees r.m.s. has been demonstrated.

  2. Summary of air permeability data from single-hole injection tests in unsaturated fractured tuffs at the Apache Leap Research Site: Results of steady-state test interpretation

    SciTech Connect

    Guzman, A.G.; Geddis, A.M.; Henrich, M.J.; Lohrstorfer, C.F.; Neuman, S.P.

    1996-03-01

    This document summarizes air permeability estimates obtained from single hole pneumatic injection tests in unsaturated fractured tuffs at the Covered Borehole Site (CBS) within the larger apache Leap Research Site (ALRS). Only permeability estimates obtained from a steady state interpretation of relatively stable pressure and flow rate data are included. Tests were conducted in five boreholes inclined at 45{degree} to the horizontal, and one vertical borehole. Over 180 borehole segments were tested by setting the packers 1 m apart. Additional tests were conducted in segments of lengths 0.5, 2.0, and 3.0 m in one borehole, and 2.0 m in another borehole, bringing the total number of tests to over 270. Tests were conducted by maintaining a constant injection rate until air pressure became relatively stable and remained so for some time. The injection rate was then incremented by a constant value and the procedure repeated. The air injection rate, pressure, temperature, and relative humidity were recorded. For each relatively stable period of injection rate and pressure, air permeability was estimated by treating the rock around each test interval as a uniform, isotropic porous medium within which air flows as a single phase under steady state, in a pressure field exhibiting prolate spheroidal symmetry. For each permeability estimate the authors list the corresponding injection rate, pressure, temperature and relative humidity. They also present selected graphs which show how the latter quantities vary with time; logarithmic plots of pressure versus time which demonstrate the importance of borehole storage effects during the early transient portion of each incremental test period; and semilogarithmic plots of pressure versus recovery time at the end of each test sequence.

  3. Determination of Zinc-Based Additives in Lubricating Oils by Flow-Injection Analysis with Flame-AAS Detection Exploiting Injection with a Computer-Controlled Syringe.

    PubMed

    Pignalosa, Gustavo; Knochen, Moisés; Cabrera, Noel

    2005-01-01

    A flow-injection system is proposed for the determination of metal-based additives in lubricating oils. The system, operating under computer control uses a motorised syringe for measuring and injecting the oil sample (200 muL) in a kerosene stream, where it is dispersed by means of a packed mixing reactor and carried to an atomic absorption spectrometer which is used as detector. Zinc was used as model analyte. Two different systems were evaluated, one for low concentrations (range 0-10 ppm) and the second capable of providing higher dilution rates for high concentrations (range 0.02%-0.2% w/w). The sampling frequency was about 30 samples/h. Calibration curves fitted a second-degree regression model (r(2) = 0.996). Commercial samples with high and low zinc levels were analysed by the proposed method and the results were compared with those obtained with the standard ASTM method. The t test for mean values showed no significant differences at the 95% confidence level. Precision (RSD%) was better than 5% (2% typical) for the high concentrations system. The carryover between successive injections was found to be negligible.

  4. Determination of Zinc-Based Additives in Lubricating Oils by Flow-Injection Analysis with Flame-AAS Detection Exploiting Injection with a Computer-Controlled Syringe

    PubMed Central

    Pignalosa, Gustavo; Cabrera, Noel

    2005-01-01

    A flow-injection system is proposed for the determination of metal-based additives in lubricating oils. The system, operating under computer control uses a motorised syringe for measuring and injecting the oil sample (200 μL) in a kerosene stream, where it is dispersed by means of a packed mixing reactor and carried to an atomic absorption spectrometer which is used as detector. Zinc was used as model analyte. Two different systems were evaluated, one for low concentrations (range 0–10 ppm) and the second capable of providing higher dilution rates for high concentrations (range 0.02%–0.2% w/w). The sampling frequency was about 30 samples/h. Calibration curves fitted a second-degree regression model (r 2 = 0.996). Commercial samples with high and low zinc levels were analysed by the proposed method and the results were compared with those obtained with the standard ASTM method. The t test for mean values showed no significant differences at the 95% confidence level. Precision (RSD%) was better than 5% (2% typical) for the high concentrations system. The carryover between successive injections was found to be negligible. PMID:18924720

  5. Autologous whole blood versus corticosteroid local injection in treatment of plantar fasciitis: A randomized, controlled multicenter clinical trial.

    PubMed

    Karimzadeh, Afshin; Raeissadat, Seyed Ahmad; Erfani Fam, Saleh; Sedighipour, Leyla; Babaei-Ghazani, Arash

    2017-03-01

    Plantar fasciitis is the most common cause of heel pain. Local injection modalities are among treatment options in patients with resistant pain. The aim of the present study was to evaluate the effect of local autologous whole blood compared with corticosteroid local injection in treatment of plantar fasciitis. In this randomized controlled multicenter study, 36 patients with chronic plantar fasciitis were recruited. Patients were allocated randomly into three treatment groups: local autologous blood, local corticosteroid injection, and control groups receiving no injection. Patients were assessed with visual analog scale (VAS), pressure pain threshold (PPT), and plantar fasciitis pain/disability scale (PFPS) before treatment, as well as 4 and 12 weeks post therapy. Variables of pain and function improved significantly in both corticosteroid and autologous blood groups compared to control group. At 4 weeks following treatment, patients in corticosteroid group had significantly lower levels of pain than patients in autologous blood and control groups (higher PPT level, lower PFPS, and VAS). After 12 weeks of treatment, both corticosteroid and autologous blood groups had lower average levels of pain than control group. The corticosteroid group showed an early sharp and then more gradual improvement in pain scores, but autologous blood group had a steady gradual drop in pain. Autologous whole blood and corticosteroid local injection can both be considered as effective methods in the treatment of chronic plantar fasciitis. These treatments decrease pain and significantly improve function compared to no treatment.

  6. [Application of nested case-control study on safe evaluation of post-marketing traditional Chinese medicine injection].

    PubMed

    Xiao, Ying; Zhao, Yubin; Xie, Yanming

    2011-10-01

    The nested case-control study design (or the case-control in a cohort study) is described here as a new study design used in safe evaluation of post-marketing traditional Chinese medicine injection. In the nested case-control study, cases of a disease that occur in a defined cohort are identified and, for each, a specified number of matched controls is selected from among those in the cohort who have not developed the disease by the time of disease occurrence in the case. For many research questions, the nested case-control design potentially offers impressive reductions in costs and efforts of data collection and analysis compared with the full cohort approach, with relatively minor loss in statistical efficiency. The nested case-control design is particularly advantageous for studies in safe evaluation of post-marketing traditional Chinese medicine injection. Some examples of the application of nested case-control study were given.

  7. CO2 spray mini-injector for digital subtraction angiography versus PC-controlled injection system: experiments in dogs.

    PubMed

    Schmitz-Rode, T; Alzen, G; Günther, R W; Pott, H

    1993-01-01

    A personal computer (PC)-controlled CO2 injector (consisting of a pneumatic unit, electric/electronic system, and calculator) and a spray mini-injector (consisting of a CO2 spray can and a dosage chamber) were used in 10 dogs to determine their efficacy regarding imaging quality and ease of handling. CO2 was injected into the abdominal aorta, renal artery, and femoral artery. The vessel diameter was determined on each CO2 arteriogram and compared with that determined on a reference arteriogram obtained using an iodinated contrast agent. The filling ratio (CO2/iodine) was calculated for each set of injection parameters. Both injection systems provided good visualization (filling ratio > 0.9) of large and small arteries within a range of injection parameters. In terms of practicality, the spray mini-injector is more appealing, because it is easier to handle and does not require any preparation.

  8. FIELD TEST PROGRAM FOR EVALUATION OF SORBENT INJECTION FOR MERCURY CONTROL

    SciTech Connect

    Sharon Sjostrom

    2004-02-12

    The power industry in the U.S. is faced with meeting new regulations to reduce the emissions of mercury compounds from coal-fired plants. These regulations are directed at the existing fleet of nearly 1,100 boilers. These plants are relatively old with an average age of over 40 years. Although most of these units are capable of operating for many additional years, there is a desire to minimize large capital expenditures because of the reduced (and unknown) remaining life of the plant to amortize the project. Injecting a sorbent such as powdered activated carbon into the flue gas represents one of the simplest and most mature approaches to controlling mercury emissions from coal-fired boilers. The overall objective of this test program described in this quarterly report is to evaluate the capabilities of activated carbon injection at four plants with configurations that together represent 78% of the existing coal-fired generation plants. This technology was successfully evaluated in NETL's Phase I tests at scales up to 150 MW, on plants burning subbituminous and bituminous coals and with ESPs and fabric filters. The tests also identified issues that still need to be addressed, such as evaluating performance on other configurations, optimizing sorbent usage (costs), and gathering longer term operating data to address concerns about the impact of activated carbon on plant equipment and operations. The four sites identified for testing are Sunflower Electric's Holcomb Station, AmerenUE's Meramec Station, AEP's Conesville Station, and Ontario Power Generation's Nanticoke Station. This is the first quarterly report for this project. This report includes an overview of the plans for the project. Field testing is scheduled to begin next quarter. In general, quarterly reports will be used to provide project overviews, project status, and technology transfer information. Topical reports will be prepared to present detailed technical information.

  9. The role of harm reduction in controlling HIV among injecting drug users

    PubMed Central

    Wodak, Alex; McLeod, Leah

    2012-01-01

    Injecting drug users (IDU) now account for one in 10 new HIV infections world wide. Yet it has been known since the early 1990s that HIV among IDU can be effectively, safely and cost-effectively controlled by the early and vigorous implementation of a comprehensive package of strategies known as ’harm reduction’. This concept means that decreasing drug-related harms is accorded an even higher priority than reduction of drug consumption. Strategies required involve: explicit and peer-based education about the risk of HIV from sharing injecting equipment; needle syringe programmes; drug treatment (including especially opiate substitution treatment) and community development. Many countries experiencing or threatened by an HIV epidemic among IDU have now adopted harm reduction but often implementation has been too little and too late. Although coverage is slowly improving in many countries, HIV is still spreading faster among IDU than harm reduction programmes while coverage in correctional centres lags far behind community settings. The scientific debate about harm reduction is now over. National and international support for harm reduction is growing while almost all the major UN organizations responsible for drug policy now support harm reduction. Only a small number of countries, led by the USA, are still vehemently opposed to harm reduction. Excessive reliance on drug law enforcement remains the major barrier to increased adoption of harm reduction. Sometimes zealous drug law enforcement undermines harm reduction. A more balanced approach to drug law enforcement is required with illicit drug use recognized primarily as a health and social problem. PMID:18641473

  10. Duct injection for SO{sub 2} control, Design Handbook, Volume 1, Process design and engineering guidelines

    SciTech Connect

    1995-09-01

    PETC developed a comprehensive program of coal-related, acid-rain research and development with a major activity area centering on flue gas cleanup and control of SO{sub 2} emissions. Particular emphasis was placed on the retrofit measures for older coal-fired power plants which predate the 1971 New Source Performance Standards. Candidate emission control technologies fall into three categories, depending upon their point of application along the fuel path (i.e., pre, during, or post combustion). The post-combustion, in-duct injection of a calcium-based chemical reagent seemed promising. Preliminary studies showed that reagent injection between the existing air heater and electrostatic precipitator (ESP) could remove between 50-60% of the SO{sub 2} and produce an environmentally safe, dry, solid waste that is easily disposed. Although SO{sub 2} removal efficiencies were less, the estimated capital costs for duct injection technology were low making the economics of duct injection systems seem favorable when compared to conventional wet slurry scrubbers under certain circumstances. With the promulgation of the Clean Air Act Amendments of 1990 came more incentive for the development of low capital cost flue gas desulfurization (FGD) processes. A number of technical problems had to be resolved, however, before duct injection technology could be brought to a state of commercial readiness. The Duct Injection Technology Development Program was launched as a comprehensive, four-year research effort undertaken by PETC to develop this new technology. Completed in 1992, this Duct Injection Design Handbook and the three-dimensional predictive mathematical model constitute two primary end products from this development program. The aim of this design handbook and the accompanying math model is to provide utility personnel with sufficient information to evaluate duct injection technology against competing SO{sub 2} emissions reduction strategies for an existing plant.

  11. Filter-based control of particulate matter from a lean gasoline direct injection engine

    SciTech Connect

    Parks, II, James E; Lewis Sr, Samuel Arthur; DeBusk, Melanie Moses; Prikhodko, Vitaly Y; Storey, John Morse

    2016-01-01

    New regulations requiring increases in vehicle fuel economy are challenging automotive manufacturers to identify fuel-efficient engines for future vehicles. Lean gasoline direct injection (GDI) engines offer significant increases in fuel efficiency over the more common stoichiometric GDI engines already in the marketplace. However, particulate matter (PM) emissions from lean GDI engines, particularly during stratified combustion modes, are problematic for lean GDI technology to meet U.S. Environmental Protection Agency Tier 3 and other future emission regulations. As such, the control of lean GDI PM with wall-flow filters, referred to as gasoline particulate filter (GPF) technology, is of interest. Since lean GDI PM chemistry and morphology differ from diesel PM (where more filtration experience exists), the functionality of GPFs needs to be studied to determine the operating conditions suitable for efficient PM removal. In addition, lean GDI engine exhaust temperatures are generally higher than diesel engines which results in more continuous regeneration of the GPF and less presence of the soot cake layer common to diesel particulate filters. Since the soot layer improves filtration efficiency, this distinction is important to consider. Research on the emission control of PM from a lean GDI engine with a GPF was conducted on an engine dynamometer. PM, after dilution, was characterized with membrane filters, organic vs. elemental carbon characterization, and size distribution techniques at various steady state engine speed and load points. The engine was operated in three primary combustion modes: stoichiometric, lean homogeneous, and lean stratified. In addition, rich combustion was utilized to simulate PM from engine operation during active regeneration of lean NOx control technologies. High (>95%) PM filtration efficiencies were observed over a wide range of conditions; however, some PM was observed to slip through the GPF at high speed and load conditions. The

  12. Injection molding of iPP samples in controlled conditions and resulting morphology

    SciTech Connect

    Sessa, Nino De Santis, Felice Pantani, Roberto

    2015-12-17

    Injection molded parts are driven down in size and weight especially for electronic applications. In this work, an investigation was carried out on the process of injection molding of thin iPP samples and on the morphology of these parts. Melt flow in the mold cavity was analyzed and described with a mathematical model. Influence of mold temperature and injection pressure was analyzed. Samples orientation was studied using optical microscopy.

  13. The MAP3S Precipitation Chemistry Network: Data and quality control summary for 1986 and 1987

    SciTech Connect

    Dana, M.T.; Barchet, W.R.

    1989-05-01

    This report, the tenth in a series documenting results from the MAP3S Precipitation Chemistry Network, contains a statistical summary of daily precipitation chemistry data from the nine-site network in the eastern United States, both for the years 1986 and 1987 individually and for the period 1977 through 1987. In addition, external quality assurance results for 1986 and 1987 are summarized. 17 refs., 21 figs., 20 tabs.

  14. Parts, materials, and processes experience summary, volume 2. [design, engineering, and quality control

    NASA Technical Reports Server (NTRS)

    1973-01-01

    This summary provides the general engineering community with the accumulated experience from ALERT reports issued by NASA and the Government-Industry. Data Exchange Program, and related experience gained by Government and industry. It provides expanded information on selected topics by relating the problem area (failure) to the cause, the investigation and findings, the suggestions for avoidance (inspections, screening tests, proper part applications, requirements for manufacturer's plant facilities, etc.), and failure analysis procedures. Diodes, integrated circuits, and transistors are covered in this volume.

  15. Subacromial impingement syndrome and pain: protocol for a randomised controlled trial of exercise and corticosteroid injection (the SUPPORT trial)

    PubMed Central

    2014-01-01

    Background Subacromial impingement syndrome is the most frequent cause of shoulder problems which themselves affect 1 in 3 adults. Management commonly includes exercise and corticosteroid injection. However, the few existing trials of exercise or corticosteroid injection for subacromial impingement syndrome are mostly small, of poor quality, and focus only on short-term results. Exercise packages tend to be standardised rather than individualised and progressed. There has been much recent interest in improving outcome from corticosteroid injections by using musculoskeletal ultrasound to guide injections. However, there are no high-quality trials comparing ultrasound-guided and blind corticosteroid injection in subacromial impingement syndrome. This trial will investigate how to optimise the outcome of subacromial impingement syndrome from exercise (standardised advice and information leaflet versus physiotherapist-led exercise) and from subacromial corticosteroid injection (blind versus ultrasound-guided), and provide long-term follow-up data on clinical and cost-effectiveness. Methods/Design The study design is a 2x2 factorial randomised controlled trial. 252 adults with subacromial impingement syndrome will be recruited from two musculoskeletal Clinical Assessment and Treatment Services at the primary-secondary care interface in Staffordshire, UK. Participants will be randomised on a 1:1:1:1 basis to one of four treatment groups: (1) ultrasound-guided subacromial corticosteroid injection and a physiotherapist-led exercise programme, (2) ultrasound-guided subacromial corticosteroid injection and an advice and exercise leaflet, (3) blind subacromial corticosteroid injection and a physiotherapist-led exercise programme, or (4) blind subacromial corticosteroid injection and an advice and exercise leaflet. The primary intention-to-treat analysis will be the mean differences in Shoulder Pain and Disability Index (SPADI) scores at 6 weeks for the comparison between

  16. CO2 migration in the vadose zone: experimental and numerical modelling of controlled gas injection

    NASA Astrophysics Data System (ADS)

    gasparini, andrea; credoz, anthony; grandia, fidel; garcia, david angel; bruno, jordi

    2014-05-01

    The mobility of CO2 in the vadose zone and its subsequent transfer to the atmosphere is a matter of concern in the risk assessment of the geological storage of CO2. In this study the experimental and modelling results of controlled CO2 injection are reported to better understanding of the physical processes affecting CO2 and transport in the vadose zone. CO2 was injected through 16 micro-injectors during 49 days of experiments in a 35 m3 experimental unit filled with sandy material, in the PISCO2 facilities at the ES.CO2 centre in Ponferrada (North Spain). Surface CO2 flux were monitored and mapped periodically to assess the evolution of CO2 migration through the soil and to the atmosphere. Numerical simulations were run to reproduce the experimental results, using TOUGH2 code with EOS7CA research module considering two phases (gas and liquid) and three components (H2O, CO2, air). Five numerical models were developed following step by step the injection procedure done at PISCO2. The reference case (Model A) simulates the injection into a homogeneous soil(homogeneous distribution of permeability and porosity in the near-surface area, 0.8 to 0.3 m deep from the atmosphere). In another model (Model B), four additional soil layers with four specific permeabilities and porosities were included to predict the effect of differential compaction on soil. To account for the effect of higher soil temperature, an isothermal simulation called Model C was also performed. Finally, the assessment of the rainfall effects (soil water saturation) on CO2 emission on surface was performed in models called Model D and E. The combined experimental and modelling approach shows that CO2 leakage in the vadose zone quickly comes out through preferential migration pathways and spots with the ranges of fluxes in the ground/surface interface from 2.5 to 600 g·m-2·day-1. This gas channelling is mainly related to soil compaction and climatic perturbation. This has significant implications to

  17. Electrokinetic injection of samples into a short electrophoretic capillary controlled by piezoelectric micropumps.

    PubMed

    Opekar, František; Nesměrák, Karel; Tůma, Petr

    2016-02-01

    Electrokinetic sample injection using two piezoelectric micropumps has been proposed for electrophoresis in short capillaries. The sample is brought to the injection end of the capillary using one of them. Then, the high-voltage source is turned on and the sample is injected electrokinetically for a defined time. The injection is terminated by removal of the sample zone by the flowing separation electrolyte pumped by the second piezoelectric micropump. The RSD value, expressing the repeatability of the injection, does not exceed 4%. The injection apparatus does not contain any mobile mechanical components, there is no movement of the capillary and both its ends remain constantly in the solution during both the sample injection and separation. Thus, the micropumps replace the six-way injection valve and linear pump in similar types of injection apparatuses. The injection was tested in the separation and determination of ammonium and potassium ions in two samples of mineral fertilizers. The separation was performed in background electrolyte containing 500 mM of acetic acid + 20 mM Tris + 2 mM 18-crown-6 (pH 3.3) in a capillary with id 50 μm and total length/length to the contactless conductivity detector of 10.5/8 cm. The injection and separation took place at a voltage of 5 kV and the separation time equaled 20 s. The measured values of the analyte contents corresponded to the value declared by the manufacturer within the reliability interval, where RSD equaled between 3.5 and 4.7%.

  18. Pain and efficacy rating of a microprocessor-controlled metered injection system for local anaesthesia in minor hand surgery.

    PubMed

    Nimigan, André S; Gan, Bing Siang

    2011-01-01

    Purpose. Little attention has been given to syringe design and local anaesthetic administration methods. A microprocessor-controlled anaesthetic delivery device has become available that may minimize discomfort during injection. The purpose of this study was to document the pain experience associated with the use of this system and to compare it with use of a conventional syringe. Methods. A prospective, randomized clinical trial was designed. 40 patients undergoing carpal tunnel release were block randomized according to sex into a two groups: a traditional syringe group and a microprocessor-controlled device group. The primary outcome measure was surgical pain and local anaesthetic administration pain. Secondary outcomes included volume of anaesthetic used and injection time. Results. Analysis showed that equivalent anaesthesia was achieved in the microprocessor-controlled group despite using a significantly lower volume of local anaesthetic (P = .0002). This same group, however, has significantly longer injection times (P < .0001). Pain during the injection process or during surgery was not different between the two groups. Conclusions. This RCT comparing traditional and microprocessor controlled methods of administering local anaesthetic showed similar levels of discomfort in both groups. While the microprocessor-controlled group used less volume, the total time for the administration was significantly greater.

  19. Controlling outbreaks of the coral-eating crown-of-thorns starfish using a single injection of common household vinegar

    NASA Astrophysics Data System (ADS)

    Boström-Einarsson, Lisa; Rivera-Posada, Jairo

    2016-03-01

    Outbreaks of the destructive coral-eating crown-of-thorns starfish, Acanthaster planci, present a considerable threat to coral reefs worldwide, and mitigating their impact has proven challenging. The most effective methods to control A. planci require injecting individual starfish with lethal chemicals. While some of these are highly effective, their administration often requires permits, training and access to specialised equipment. We aimed to identify a widely available and highly efficient alternative. We discovered that common household vinegar is lethal to A. planci individuals when injected at the base of one their arms. A single injection of 25 ml vinegar induced functional mortality in <24 h and 100 % mortality in <48 h. These results demonstrate that vinegar is an effective alternative to currently used chemicals. Vinegar is a viable alternative in the toolkit of methods that can control and eradicate local outbreaks of COTS on coral reefs.

  20. A double-blind randomised controlled study comparing subacromial injection of tenoxicam or methylprednisolone in patients with subacromial impingement.

    PubMed

    Karthikeyan, S; Kwong, H T; Upadhyay, P K; Parsons, N; Drew, S J; Griffin, D

    2010-01-01

    We have carried out a prospective double-blind randomised controlled trial to compare the efficacy of a single subacromial injection of the non-steroidal anti-inflammatory drug, tenoxicam, with a single injection of methylprednisolone in patients with subacromial impingement. A total of 58 patients were randomly allocated into two groups. Group A received 40 mg of methylprednisolone and group B 20 mg of tenoxicam as a subacromial injection along with lignocaine. The Constant-Murley shoulder score was used as the primary outcome measure and the Disability of Arm, Shoulder and Hand (DASH) and the Oxford Shoulder Score (OSS) as secondary measures. Six weeks after injection the improvement in the Constant-Murley score was significantly greater in the methylprednisolone group (p = 0.003) than in the tenoxicam group. The improvement in the DASH score was greater in the steroid group and the difference was statistically significant and consistent two (p < 0.01), four (p < 0.01) and six weeks (p < 0.020) after the injection. The improvement in the OSS was consistently greater in the steroid group than in the tenoxicam group. Although the difference was statistically significant at two (p < 0.001) and four (p = 0.003) weeks after the injection, it was not at six weeks (p = 0.055). Subacromial injection of tenoxicam does not offer an equivalent outcome to subacromial injection of corticosteroid at six weeks. Corticosteroid is significantly better than tenoxicam for improving shoulder function in tendonitis of the rotator cuff after six weeks.

  1. Nanofibrous yet injectable polycaprolactone-collagen bone tissue scaffold with osteoprogenitor cells and controlled release of bone morphogenetic protein-2.

    PubMed

    Subramanian, Gayathri; Bialorucki, Callan; Yildirim-Ayan, Eda

    2015-06-01

    In this work, we developed a nanofibrous, yet injectable orthobiologic tissue scaffold that is capable of hosting osteoprogenitor cells and controlling kinetic release profile of the encapsulated pro-osteogenic factor without diminishing its bioactivity over 21days. This innovative injectable scaffold was synthesized by incorporating electrospun and subsequently O2 plasma-functionalized polycaprolactone (PCL) nanofibers within the collagen type-I solution along with MC3T3-E1 cells (pre-osteoblasts) and bone morphogenetic protein-2 (BMP2). Through changing the PCL nanofiber concentration within the injectable scaffolds, we were able to tailor the mechanical strength, protein retention capacity, bioactivity preservation, and osteoinductive potential of the scaffolds. The nanofibrous internal structure of the scaffold allowed us to use a low dose of BMP2 (200ng/ml) to achieve osteoblastic differentiation in in vitro culture. The osteogenesis capacity of the injectable scaffolds were evaluated though measuring MC3T3-E1 cell proliferation, ALP activity, matrix mineralization, and early- and late-osteoblast specific gene expression profiles over 21days. The results demonstrated that the nanofibrous injectable scaffold provides not only an osteoinductive environment for osteoprogenitor cells to differentiate, but also a suitable biomechanical and biochemical environment to act as a reservoir for osteogenic factors with controlled release profile.

  2. Differences in postoperative opioid consumption in patients prescribed patient-controlled analgesia versus intramuscular injection.

    PubMed

    Everett, Bronwyn; Salamonson, Yenna

    2005-12-01

    The purpose of this study was to examine differences in opioid consumption in patients prescribed patient-controlled analgesia (PCA) versus intramuscular injection (IMI) in the early postoperative period after open abdominal surgery. A retrospective audit of 115 patients elicited demographic and clinical data. No significant differences were found between the demographic variables of the PCA and IMI groups. There was a significant difference in the mean opioid dose used during the first 3 postoperative days (p < .01). Mean opioid consumption was 136.89 mg for the PCA group and 50.79 mg for the IMI group. Although there was a reduction in the amount of opioid consumed over the first 3 postoperative days, the PCA group consistently consumed more opioid analgesia compared with the IMI group. Furthermore, there was a disproportionate reduction in opioid consumption between the two groups from Day 1 (r = .34; p < .01) to Day 3 (r = .14; p = .14). This study shows that the amount of analgesia consumed during the postoperative period by patients who had abdominal surgery varied markedly depending on the mode of analgesia (PCA or IMI). The difference in analgesic consumption was also found to increase throughout the 3-day postoperative period. This divergence in the amount of opioid consumption between patients who were prescribed PCA and patients who were prescribed IM analgesia heightens the need for vigilance in assessment and management of pain during the early postoperative period, particularly in patients prescribed IM analgesia on an "as-needed" basis.

  3. Advanced in-duct sorbent injection for SO{sub 2} control. Final technical report

    SciTech Connect

    Stouffer, M.R.; Withium, J.A.; Rosenhoover, W.A.; Maskew, J.T.

    1994-12-01

    The objective of this research project was to develop a second generation duct sorbent injection technology as a cost-effective compliance option for the 1990 Clean Air Act Amendments. Research and development work was focused on the Advanced Coolside process, which showed the potential for exceeding the original performance targets of 90% SO{sub 2} removal and 60% sorbent utilization. Process development was conducted in a 1000 acfm pilot plant. The pilot plant testing showed that the Advanced Coolside process can achieve 90% SO{sub 2} removal at sorbent utilizations up to 75%. The testing also showed that the process has the potential to achieve very high removal efficiency (90 to >99%). By conducting conceptual process design and economic evaluations periodically during the project, development work was focused on process design improvements which substantially lowered process capital and operating costs, A final process economic study projects capital costs less than one half of those for limestone forced oxidation wet FGD. Projected total SO{sub 2} control cost is about 25% lower than wet FGD for a 260 MWe plant burning a 2.5% sulfur coal. A waste management study showed the acceptability of landfill disposal; it also identified a potential avenue for by-product utilization which should be further investigated. Based on the pilot plant performance and on the above economic projections, future work to scale up the Advanced Coolside process is recommended.

  4. Controlling device for a fuel-quantity adjusting member of a fuel injection pump

    SciTech Connect

    Eheim, F.; Hofer, G.; Konrath, K.; Straubel, M.

    1987-11-03

    This patent describes a controlling device for a fuel-quantity adjustment element of a fuel injection pump including an adjusting lever pivotable around a shaft. The adjusting lever is coupled with a fuel-quantity adjusting element, a drag lever pivotable around the shaft of the adjusting lever. The drag lever communicates with the adjusting lever by way of a coupling element. An adjustable governor spring assembly is arranged to act on the drag lever, a stop for stopping the drag lever, further including a device for generating rpm-dependent force transmittable to the drag lever by means of an actuating element thereof and counter to the governor spring assembly, whereby the drag lever and the adjusting lever are coupled for movement together at least at the end of each relative movement effected by the actuating element. The actuating element acts directly upon the drag lever and the adjusting lever during deflection by way of a predetermined relative adjustment distance between the drag lever and the adjusting lever for adjustment by the actuating element, at least one spring arranged between the adjusting lever and a fixed support. At least one spring acts on the adjusting lever to force the adjusting lever into contact with an adjustable stop which is adjustable in dependence from the operating parameters of the combustion engine.

  5. Iron pyrite: Phase and shape control by facile hot injection method

    NASA Astrophysics Data System (ADS)

    Trinh, Thanh Kieu; Pham, Viet Thanh Hau; Truong, Nguyen Tam Nguyen; Kim, Chang Duk; Park, Chinho

    2017-03-01

    Pure phases of cubic and spherical FeS2 nanocrystals (NCs) with the mean size of 80 nm and 30 nm, respectively, were obtained using trioctylamine and oleylamine as the solvents to dissolve the sulfur source via a facile and efficient hot injection method. The pure phase formation and shape control were strongly dependent on the concentration of active sulfur source (H2S) that could be formed by the reaction between the elemental sulfur and a primary amine. The chemically active sulfur source could facilitate the formation of a pure FeS2 phase from a FeS phase via a Fe3S4 phase. In addition, the active sulfur concentration is believed to be the main factor to drive the orientation attachment to obtain different shapes of FeS2 NCs. The obtained FeS2 pyrite NCs with excellent phase purity and good optical properties are believed to have potential applications to various energy devices including low-cost photovoltaics.

  6. Field evaluation of natural gas and dry sorbent injection for MWC emissions control

    SciTech Connect

    Wohadlo, S; Abbasi, H; Cygan, D

    1993-10-01

    The Institute of Gas Technology (IGT), in cooperation with the Olmsted Waste-to-Energy Facility (OWEF) and with subcontracted engineering services from the Energy and Environmental Research Corporation (EER), has completed the detailed engineering and preparation of construction specifications for an Emissions Reduction Testing System (ERTS). The ERTS has been designed for retrofit to one of two 100-ton/day municipal waste combustors at the OWEF, located in Rochester, Minnesota. The purpose of the retrofit is to conduct a field evaluation of a combined natural gas and sorbent injection process (IGT`s METHANE de-TOX{sup SM}, IGT Patent No. 5,105,747) for reducing the emissions of oxides of nitrogen (NO{sub x}), hydrochloric acid (HCI), oxides of sulfur (SO{sub x}), carbon monoxide (CO), total hydrocarbons (THC), and chlorinated hydrocarbons (dioxin/furans). In addition, the design includes modifications for the control of heavy metals (HM). Development of the process should allow the waste-to-energy industry to meet the Federal New Source Performance Standards for these pollutants at significantly lower costs when compared to existing technology of Thermal deNO{sub x} combined with spray dryer scrubber/fabric filters. Additionally, the process should reduce boiler corrosion and increase both the thermal and power production efficiency of the facility.

  7. A digital computer propulsion control facility: Description of capabilities and summary of experimental program results

    NASA Technical Reports Server (NTRS)

    Zeller, J. R.; Arpasi, D. J.; Lehtinen, B.

    1976-01-01

    Flight weight digital computers are being used today to carry out many of the propulsion system control functions previously delegated exclusively to hydromechanical controllers. An operational digital computer facility for propulsion control mode studies has been used successfully in several experimental programs. This paper describes the system and some of the results concerned with engine control, inlet control, and inlet engine integrated control. Analytical designs for the digital propulsion control modes include both classical and modern/optimal techniques.

  8. Future Air Force aircraft propulsion control systems: The extended summary paper

    NASA Technical Reports Server (NTRS)

    Skira, C. A.

    1980-01-01

    Hydromechanical control technology simply cannot compete against the performance benefits offered by electronics. Future military aircraft propulsion control systems will be full authority, digital electronic, microprocessor base systems. Anticipating the day when microprocessor technology will permit the integration and management of aircraft flight control, fire control and propulsion control systems, the Air Force Aero Propulsion Laboratory is developing control logic algorithms for a real time, adaptive control and diagnostic information system.

  9. First demonstration and performance of an injection locked continuous wave magnetron to phase control a superconducting cavity

    SciTech Connect

    A.C. Dexter, G. Burt, R.G. Carter, I. Tahir, H. Wang, K. Davis, R. Rimmer

    2011-03-01

    The applications of magnetrons to high power proton and cw electron linacs are discussed. An experiment is described where a 2.45 GHz magnetron has been used to drive a single cell superconducting cavity. With the magnetron injection locked, a modest phase control accuracy of 0.95° rms has been demonstrated. Factors limiting performance have been identified.

  10. Intelligent emissions controller for substance injection in the post-primary combustion zone of fossil-fired boilers

    DOEpatents

    Reifman, Jaques; Feldman, Earl E.; Wei, Thomas Y. C.; Glickert, Roger W.

    2003-01-01

    The control of emissions from fossil-fired boilers wherein an injection of substances above the primary combustion zone employs multi-layer feedforward artificial neural networks for modeling static nonlinear relationships between the distribution of injected substances into the upper region of the furnace and the emissions exiting the furnace. Multivariable nonlinear constrained optimization algorithms use the mathematical expressions from the artificial neural networks to provide the optimal substance distribution that minimizes emission levels for a given total substance injection rate. Based upon the optimal operating conditions from the optimization algorithms, the incremental substance cost per unit of emissions reduction, and the open-market price per unit of emissions reduction, the intelligent emissions controller allows for the determination of whether it is more cost-effective to achieve additional increments in emission reduction through the injection of additional substance or through the purchase of emission credits on the open market. This is of particular interest to fossil-fired electrical power plant operators. The intelligent emission controller is particularly adapted for determining the economical control of such pollutants as oxides of nitrogen (NO.sub.x) and carbon monoxide (CO) emitted by fossil-fired boilers by the selective introduction of multiple inputs of substances (such as natural gas, ammonia, oil, water-oil emulsion, coal-water slurry and/or urea, and combinations of these substances) above the primary combustion zone of fossil-fired boilers.

  11. 76 FR 56982 - Announcement of Federal Underground Injection Control (UIC) Class VI Program for Carbon Dioxide (CO2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... (UIC) Class VI Program for Carbon Dioxide (CO 2 ) Geologic Sequestration (GS) Wells AGENCY... establishment of a Federal Underground Injection Control (UIC) Class VI Program for Carbon Dioxide (CO 2... highlighted in the ``Report of the Interagency Task Force on Carbon Capture and Storage'' (August 2010), it...

  12. Plastic Injection Quality Controlling Using the Lean Six Sigma and FMEA Method

    NASA Astrophysics Data System (ADS)

    Mansur, A.; Mu'alim; Sunaryo

    2016-01-01

    PT. Yogya Presisi Teknikatama Industri (PT. YPTI) is a mold, precision part, and plastic injection maker company. One of the obstacles faced by the company is the high level of nonconformity on its production results. The waste on production process can be identified and classified into four types, i.e.: a). during the process of injection molding machines, b). finishing and cutting processes, c). quality control process and d). the packaging process. The objectives of this research are minimizing the defective goods and reducing the waste using Lean Six Sigma and FMEA approaches, especially for Bush product. From the analysis result, defective types on Bush product can be classified into bubble, speckle, short shoot, sunken, sink mark, over-cut, flashing, and discolor. Based on the attributes data on Bush product, the DPMO score is 988.42 or the sigma level is 4.6, While the DPMO score on the variable data on each dimension i.e.: a). Slit width on the bottom side has DPMO score of 30119 (sigma level 3.37), b). Diameter of the circle on the top side has DPMO score of 392294 (sigma level 1.77), c). Product thickness on the top side has DPMO score of 70474 (sigma level 2.97), d). Product height has DPMO score of 82107 (sigma level 2.89), product thickness on the bottom side has DPMO score of 24448 (sigma level 3.47), and f). Diameter of the circle on the bottom side has DPMO score of 24448 (sigma level 3.47). The highest RPN score on the dominant types of product defects which needs improvement are the defective goods of bubble type has RPN score of 729, flashing and the molten material out on the heating channel has RPN score of 384, over cutting has RPN score of 324 and sink mark has RPN score of 270. The recommendations for improvement that can be given from this research are making checklist for maintenance and production monitoring, enhancing work supervision and inspection, as well as improving the environment and work stations.

  13. Tests of ionospheric control of young injection events identified from magnetometer observations at Saturn

    NASA Astrophysics Data System (ADS)

    Kivelson, M.; Jia, X.

    2015-12-01

    Kennelly et al. (2013) reported that young plasma injection events observed in Saturn's nightside magnetosphere and identified from plasma wave signatures are modulated at the period associated with the winter hemisphere. In a system unstable to interchange, radial motion of flux tubes is constrained by the "line-tying" effect of high ionospheric conductance (Southwood and Kivelson, 1989). Slippage of a flux tube would then occur initially in the hemisphere in which the ionospheric conductance is lowest. Saturn's ionospheric conductances vary not only with season, but also with rotation phase because of the presence of a pattern of rotating field-aligned currents that drive "planetary period oscillations" (Jia and Kivelson, 2012). The conductance should minimize near the center of the downward current region and, at this rotation phase in the winter hemisphere, the growth rate of the instability would be largest, accounting for control by the northern period. With motion starting in the winter hemisphere, the flux tube would develop a tilt of predictable sense and the initial inward motion of the interchanging flux tube would occur at a specific rotation phase of the winter ionosphere. For a subset of the Kennelly events, we found that the tilt and phase are consistent with expectations based on the control of displacement by ionospheric conductance. Many additional young interchange events have been identified by K. K. Khurana [personal communication, 2015] whom we thank for making the list available. We examine this more extensive set of events and use them to investigate the proposed mechanism more fully. __________ Jia, X., and M. G. Kivelson (2012), J. Geophys. Res., 117, A11219. Kennelly, T. J., J. S. Leisner, G. B. Hospodarsky, and D. A. Gurnett (2013), J. Geophys. Res. Space Physics, 118, 832-838. Kivelson, M., and X. Jia (2014), , AGU Fall meeting, 2014, SM51E-4295. Southwood, D. J., and M. G. Kivelson (1989), J. Geophys. Res., 94, 299-308.

  14. Injectable hydrogels embedded with alginate microspheres for controlled delivery of bone morphogenetic protein-2.

    PubMed

    Zhu, Youjia; Wang, Jiulong; Wu, Jingjing; Zhang, Jun; Wan, Ying; Wu, Hua

    2016-03-23

    Some delivery carriers with injectable characteristics were built using the thermosensitive chitosan/dextran-polylactide/glycerophosphate hydrogel and selected alginate microspheres for the controllable release of bone morphogenetic protein-2 (BMP-2). BMP-2 was first loaded into the microspheres with an average size of around 20 μm and the resulting microspheres were then embedded into the gel in order to achieve well-controlled BMP-2 release. The microsphere-embedded gels show their incipient gelation temperature at around 32 °C and pH at about 7.1. Some gels had their elastic modulus close to 1400 Pa and the ratio of elastic modulus to viscous modulus at around 34, revealing that they behaved like mechanically strong gels. Optimized microsphere-embedded gels were found to be able to administer the BMP-2 release without significant initial burst release in an approximately linear manner over a period of time longer than four weeks. The release rate and the released amount of BMP-2 from these gels could be regulated individually or cooperatively by the initial BMP-2 load and the dextran-polylactide content in the gels. Measurements of the BMP-2 induced alkaline phosphatase activity in C2C12 cells confirmed that C2C12 cells responded to BMP-2 in a dose-dependent way and the released BMP-2 from the microsphere-embedded gels well retained their bioactivity. In vivo assessment of some gels revealed that the released BMP-2 maintained its osteogenesis functions.

  15. Efficacy of acupuncture versus local methylprednisolone acetate injection in De Quervain's tenosynovitis: a randomized controlled trial.

    PubMed

    Hadianfard, Mohammadjavad; Ashraf, Alireza; Fakheri, Maryamsadat; Nasiri, Aref

    2014-06-01

    There is no consensus on the management of De Quervain's tenosynovitis, but local corticosteroid injection is considered the mainstay of treatment. However, some patients are reluctant to take steroid injections. This study was performed to compare the efficacy of acupuncture versus corticosteroid injection for the treatment of this disease. Thirty patients were consequently treated in two groups. The acupuncture group received five acupuncture sessions of 30 minutes duration on classic points of LI-5, LU-7, and LU-9 and on ahshi points. The injection group received one methylprednisolone acetate injection in the first dorsal compartment of the wrist. The degree of disability and pain was evaluated by using the Quick Disabilities of the Arm, Shoulder, and Hand (Q-DASH) scale and the Visual Analogue Scale (VAS) at baseline and at 2 weeks and 6 weeks after the start of treatment. The baseline means of the Q-DASH and the VAS scores were 62.8 and 6.9, respectively. At the last follow-up, the mean Q-DASH scores were 9.8 versus 6.2 in the acupuncture and injection groups, respectively, and the mean VAS scores were 2 versus 1.2. We demonstrated short-term improvement of pain and function in both groups. Although the success rate was somewhat higher with corticosteroid injection, acupuncture can be considered as an alternative option for treatment of De Quervain's tenosynovitis.

  16. Aminocaproic Acid Injection

    MedlinePlus

    Aminocaproic acid injection is used to control bleeding that occurs when blood clots are broken down too quickly. This ... the baby is ready to be born). Aminocaproic acid injection is also used to control bleeding in ...

  17. Summary of Resources for the International Space Station Environmental Control and Life Support System For Core Complete Modules

    NASA Technical Reports Server (NTRS)

    Williams, David E.

    2004-01-01

    The Core Complete Environmental Control and Life Support (ECLS) System for the International Space Station (ISS) will consist of components and subsystems in both the United States (U.S.) and International Partner elements which together will perform the functions of Temperature and Humidity Control (THC), Atmosphere Control and Supply (ACS), Atmosphere Revitalization (AR), Water Recovery and Management (WRM), Fire Detection and Suppression (FDS), and Vacuum System (VS) for the station. Due to limited resources available on ISS, detailed attention is given to minimizing and tracking all resources associated with all systems, beginning with estimates during the hardware development phase through measured actuals when flight hardware is built and delivered. A summary of resources consumed by the addition of future U.S. ECLS system hardware to get to Core Complete is presented, including launch weight, average continuous and peak power loads, on-orbit volume and resupply logistics.

  18. Injectable Chemically Crosslinked Hydrogel for the Controlled Release of Bevacizumab in Vitreous: A 6-Month In Vivo Study

    PubMed Central

    Yu, Yu; Lau, Laurence Chi Ming; Lo, Amy Cheuk-yin; Chau, Ying

    2015-01-01

    can reduce the injection frequency, its associated complications, and treatment cost, which will be beneficial to both the patients and doctors. In this study, we showed that the in situ hydrogel-based controlled release system is a feasible option to tackle this problem. PMID:25774331

  19. The Texas Railroad Commission, Oil and Gas Division underground injection control program: A peer review

    SciTech Connect

    Not Available

    1989-01-01

    The reports included herein and any reports added subsequently are the result of an effort to evaluate the effectiveness of state programs to protect Underground Sources of Drinking Water (USDW) from potential contamination resulting from the operation of injection wells related to the production of oil and gas (Class II injection wells). The programs examined in this study cover wells which are used for the injection of fluids into oil reservoirs for the purpose of stimulating or furthering their production when natural production mechanisms decline or cease (enhanced recovery wells) and for the disposal of waters produced in conjunction with the production of oil and gas (disposal wells). The programs examined are those where primary enforcement authority has been delegated to the states by the US Environmental Protection Agency (EPA) under provisions of the Safe Drinking Water Act and EPA regulations (see following UIC Development Section of this report). The study was conducted under the auspices of the Underground Injection Practices Council (UIPC).

  20. Modeling of the flow continuum and optimal design of control-oriented injection systems in liquid composite molding processes

    NASA Astrophysics Data System (ADS)

    Gokce, Ali

    time and reject ratio of LCM processes by providing an accurate and complete model of the flow continuum and optimal control-oriented injection design solutions, increasing the profitability and feasibility of the process.

  1. Safety and pharmacodynamics of suprachoroidal injection of triamcinolone acetonide as a controlled ocular drug release model.

    PubMed

    Chen, Mei; Li, Xiaoli; Liu, Jinkun; Han, Yin; Cheng, Lingyun

    2015-04-10

    Suprachoroidal injection is an emerging technique for drug delivery to the posterior segment, which is hard to reach by non-invasive approaches. However, the injection technique varies and the associated ocular safety is not well understood. In addition, it is not clear if drug formulation is a major factor in optimizing pharmacodynamics using this technique. The current study was designed to compare the suprachoroidal injection of different drug formulations and to characterize the safety and pharmacodynamics of triamcinolone acetonide (TA) delivered by this technique. Both indocyanine green (ICG) solution and TA suspension, at 50μL, 100μL, and 150μL, were suprachoroidally injected and intraocular pressure (IOP) tonometry, fundus photography, and electroretinography were performed over multiple time points up to eight weeks. After 50μL TA (Kenalog-40) suprachoroidal injection, 4-5 animals at 7 time points were sacrificed for aqueous, vitreous, retina, and plasma collections. TA was quantitated using ultra-performance liquid chromatography tandem mass spectrometry. For comparative efficacy study, 50μL (2mg) suprachoroidal TA versus 20mg subtenon TA were performed 4weeks before induction of experimental uveitis with 10ng of intravitreal lipopolysaccharide. After suprachoroidal injection, IOP had an acute elevation, higher volume caused higher IOP (p<0.0001). Equivalent volume of ICG solution led to a significantly smaller IOP elevation than after TA suprachoroidal injection. This finding suggests better distribution of ICG solution than TA suspension in the suprachoroidal space. Following a 50μL suprachoroidal injection, peak TA concentration in the aqueous was below 1ng/mL. In contrast, the posterior vitreous and retina had 1912ng/mL and 400,369ng/mL TA, respectively. Maximum TA in plasma was 11.6ng/mL. Drug exposure to the posterior retina was 523,910 times more than that to the aqueous and 29,516 times more than systemic TA exposure. In the treatment of

  2. Prototype demonstration of dual sorbent injection for acid gas control on municipal solid waste combustion units

    SciTech Connect

    1994-05-01

    This report gathered and evaluated emissions and operations data associated with furnace injection of dry hydrated lime and duct injection of dry sodium bicarbonate at a commercial, 1500 ton per day, waste-to-energy facility. The information compiled during the project sheds light on these sorbents to affect acid gas emissions from municipal solid waste combustors. The information assesses the capability of these systems to meet the 1990 Clean Air Act and 1991 EPA Emission Guidelines.

  3. How Computational Modeling of Geologic Sequestration of Carbon Dioxide will be used in the Underground Injection Control program

    NASA Astrophysics Data System (ADS)

    McDonald, J. R.

    2011-12-01

    The greenhouse gas mitigation technique of sequestering large volumes of carbon dioxide underground holds the promise of significantly reducing the amounts of carbon dioxide that the world contributes to the atmosphere. During the past few years, the United States Environmental Protection Agency evaluated the potential risks associated with the injection of large masses of carbon dioxide and determined that those risks would be best addressed through the development of a new well class under the Safe Drinking Water Act's Underground Injection Control (UIC) program. The large quantities of injected carbon dioxide, its mobile and buoyant nature, and its potential to alter the chemistry of formations it might leak into were part of this evaluation. The regulations under this new well class, Class VI, were built upon the existing requirements for Class I wells that dispose of industrial waste fluids. One of the key elements of the new regulations is the role of the computational modeling of the injected carbon dioxide and the associated pressure effects in the injection zone. A series of requirements and possible actions will cascade from the site characterization and computational modeling results. The requirements for ongoing subsurface monitoring and the reevaluation of carbon dioxide plume movement and pressure effects every five years will requite the regulators and the regulated to compare computational modeling results with observations frequently.

  4. Hydrogeologic controls on induced seismicity in crystalline basement rocks due to fluid injection into basal reservoirs.

    PubMed

    Zhang, Yipeng; Person, Mark; Rupp, John; Ellett, Kevin; Celia, Michael A; Gable, Carl W; Bowen, Brenda; Evans, James; Bandilla, Karl; Mozley, Peter; Dewers, Thomas; Elliot, Thomas

    2013-01-01

    A series of Mb 3.8-5.5 induced seismic events in the midcontinent region, United States, resulted from injection of fluid either into a basal sedimentary reservoir with no underlying confining unit or directly into the underlying crystalline basement complex. The earthquakes probably occurred along faults that were likely critically stressed within the crystalline basement. These faults were located at a considerable distance (up to 10 km) from the injection wells and head increases at the hypocenters were likely relatively small (∼70-150 m). We present a suite of simulations that use a simple hydrogeologic-geomechanical model to assess what hydrogeologic conditions promote or deter induced seismic events within the crystalline basement across the midcontinent. The presence of a confining unit beneath the injection reservoir horizon had the single largest effect in preventing induced seismicity within the underlying crystalline basement. For a crystalline basement having a permeability of 2 × 10(-17)  m(2) and specific storage coefficient of 10(-7) /m, injection at a rate of 5455 m(3) /d into the basal aquifer with no underlying basal seal over 10 years resulted in probable brittle failure to depths of about 0.6 km below the injection reservoir. Including a permeable (kz  = 10(-13)  m(2) ) Precambrian normal fault, located 20 m from the injection well, increased the depth of the failure region below the reservoir to 3 km. For a large permeability contrast between a Precambrian thrust fault (10(-12)  m(2) ) and the surrounding crystalline basement (10(-18)  m(2) ), the failure region can extend laterally 10 km away from the injection well.

  5. Air Force Command and Control: The Path Ahead. Volume 1: Summary

    DTIC Science & Technology

    2000-12-01

    B-1 Appendix C Acronyms and Abbreviations... C -1 Appendix D Top-Level Organizations...direction, and control over deployed air resources. The AOC supports COMAFFOR, C /JFACC, the Airspace Control Authority, and/or the Area Air

  6. Colliding pulse injection experiments in non-collinear geometry for controlled laser plasma wakefield acceleration of electrons

    NASA Astrophysics Data System (ADS)

    Toth, Csaba; Nakamura, K.; Geddes, C.; Michel, P.; Schroeder, C.; Esarey, E.; Leemans, W.

    2006-10-01

    A method for controlled injection of electrons into a plasma wakefield relying on colliding laser pulses [1] has been proposed a decade ago to produce high quality relativistic electron beams with energy spread below 1% and normalized emittances < 1 micron from a laser wakefield accelerator (LWFA). The original idea uses three pulses in which one pulse excites the plasma wake and a trailing laser pulse collides with a counterpropagating one to form a beat pattern that boosts background electrons to catch the plasma wave. Another, two-beam off-axis injection method [2] with crossing angles varying from 180 to 90 degrees avoids having optical elements on the path of the electron beam and has been studied at the LOASIS facility of LBNL as a viable method for laser triggered injection. It allows low dark current operation with controllable final beam energy and low energy spread. Here, we report on progress of electron optical injection via the two-beam non-collinear colliding pulse scheme using multi-terawatt Ti:Sapphire laser beams (45 fs, 100s of mJ) focused onto a Hydrogen gas plume. Experimental results indicate that electron beam properties are affected by the second beam. *This work is supported by DoE under contract DE-AC02-05CH11231. [1] E. Esarey, et al, Phys. Rev. Lett 79, 2682 (1997) [2] G. Fubiani, Phys. Rev. E 70, 016402 (2004)

  7. Patient satisfaction and clinical outcome after injecting gonadotropins with use of a needle-free carbon dioxide injection system for controlled ovarian hyperstimulation for in vitro fertilization.

    PubMed

    Solnica, Amy; Oh, Cheongeun; Cho, Michael M; Loughlin, Jacquelyn S; McCulloh, David H; McGovern, Peter G

    2009-10-01

    In this prospective, randomized clinical trial, we tested the hypothesis that a needle-free CO(2) injection system (Biojector 2000) would be better tolerated by patients when compared with traditional sharp needles used for gonadotropin injections during stimulation for IVF. As measured by our questionnaire, the needle-free CO(2) injection system was not better tolerated by patients, even though it was equally effective clinically.

  8. Diffusion and Controlled Localized Drug Release from an Injectable Solid Self-Assembling Peptide Hydrogel

    NASA Astrophysics Data System (ADS)

    Sun, Jessie E. P.; Stewart, Brandon; Langhans, Sigrid; Stewart, Joel P.; Pochan, Darrin J.

    2014-03-01

    We use an injectable solid peptide hydrogel (first assembled into a solid hydrogel, can shear-thin flow and immediately reheal on cessation of shear) as a drug delivery vehicle for sustained and active drug release. The triggered intramolecular peptide folding into a beta-hairpin leads to intermolecular assmebly of the peptides into the entangled and branched nanofibrillar hydrogel network responsible for its advantageous rheological properties. The hydrogel is used to encapsulate a highly effective chemotherapeutic, vincristine, with hydrophobic behavior. We show that we are able to constantly maintain drug release in low but still potent concentrations after the shear-thinning injection process. Similarly, the mechanical and morphoogical properties of the gels remains identical after injection. Characterization of the hydrogel construct is through tritiated vincristine release, TEM, confocal microscopy, and in vitro methods.

  9. Development of a novel pH sensitive silane crosslinked injectable hydrogel for controlled release of neomycin sulfate.

    PubMed

    Jabeen, Sehrish; Islam, Atif; Ghaffar, Abdul; Gull, Nafisa; Hameed, Ayesha; Bashir, Anbreen; Jamil, Tahir; Hussain, Tousif

    2017-04-01

    Silane crosslinked biopolymer based novel pH-responsive hydrogels were fabricated by blending the cationic (chitosan) and anionic (alginate) polymers with poly(vinyl alcohol). Tetraethoxysilane (TEOS) was used, as a crosslinker in different amounts due to its nonhazardous nature, to study its impact on physical and chemical properties of the prepared injectable hydrogels along with the controlled release of drug. The swelling response of the prepared hydrogels was examined in different solvent media which exhibited decreased swelling ratio with increase in the amount of TEOS. All the fabricated hydrogels represented highest swelling at acidic pH while low swelling at basic and neutral pH. This specific pH sensitive behavior at pH 7 made them an appropriate candidate for the injectable controlled drug delivery in which Neomycin Sulfate (NMS) was successfully loaded on suitable hydrogel (comprising 50μL TEOS) to study its release mechanism. The results revealed that in simulated gastric fluid (SGF), hydrogel released the entire drug (NMS) in initial 30min while in simulated intestinal fluid (SIF), NMS was released in a controlled way up to 83% in 80min. These results endorsed that the hydrogels could be practiced as a smart intelligent material for injectable controlled drug delivery as well as for other biomedical applications at physiological pH.

  10. Full-scale evaluation of mercury control with sorbent injection and COHPAC at Alabama Power E.C. Gaston.

    PubMed

    Bustard, C Jean; Durham, Michael; Lindsey, Charles; Starns, Travis; Baldrey, Ken; Martin, Cameron; Schlager, Richard; Sjostrom, Sharon; Slye, Rick; Renninger, Scott; Monroe, Larry; Miller, Richard; Chang, Ramsay

    2002-08-01

    The overall objective of this project was to determine the cost and impacts of Hg control using sorbent injection into a Compact Hybrid Particulate Collector (COHPAC) at Alabama Power's Gaston Unit 3. This test is part of a program funded by the U.S. Department of Energy's National Energy Technology Laboratory (NETL) to obtain the necessary information to assess the costs of controlling Hg from coal-fired utility plants that do not have scrubbers for SO2 control. The economics will be developed based on various levels of Hg control. Gaston Unit 3 was chosen for testing because COHPAC represents a cost-effective retrofit option for utilities with existing electrostatic precipitators (ESPs). COHPAC is an EPRI-patented concept that places a high air-to-cloth ratio baghouse downstream of an existing ESP to improve overall particulate collection efficiency. Activated carbons were injected upstream of COHPAC and downstream of the ESP to obtain performance and operational data. Results were very encouraging, with up to 90% removal of Hg for short operating periods using powdered activated carbon (PAC). During the long-term tests, an average Hg removal efficiency of 78% was measured. The PAC injection rate for the long-term tests was chosen to maintain COHPAC cleaning frequency at less than 1.5 pulses/bag/hr.

  11. Summary of NASA/DOE Aileron-Control Development Program for Wind Turbines

    NASA Technical Reports Server (NTRS)

    Miller, D. R.

    1986-01-01

    The development of aileron-control for wind turbines is discussed. Selected wind tunnel test results and full-scale rotor test results are presented for various types of ailerons. Finally, the current status of aileron-control development is discussed. Aileron-control was considered as a method of rotor control for use on wind turbines based on its potential to reduce rotor weight and cost. Following an initial feasibility study, a 20 percent chord aileron-control rotor was fabricated and tested on the NASA/DOE Mod-0 experimental wind turbine. Results from these tests indicated that the 20 percent chord ailerons regulated power and provided overspeed protection, but only over a very limited windspeed range. The next aileron-control rotor to be tested on the Mod-0 had 38 percent chord ailerons and test results showed these ailerons provided overspeed protection and power regulation over the Mod-0's entire operational windspeed range.

  12. Annual Anastasia Arbovirus Surveillance and Mosquito Control Workshops: Summary of the Past 11 Years

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Realizing the needs of local mosquito control workers for advance training and education the Anastasia Mosquito Control District (AMCD) and the USDA-ARS Center for Medical, Agricultural and Veterinary entomology (CMAVE) developed a regional workshop to address these needs. Since 2004 the AMCD and CM...

  13. Space vehicle electrical power processing distribution and control study. Volume 1: Summary

    NASA Technical Reports Server (NTRS)

    Krausz, A.

    1972-01-01

    A concept for the processing, distribution, and control of electric power for manned space vehicles and future aircraft is presented. Emphasis is placed on the requirements of the space station and space shuttle configurations. The systems involved are referred to as the processing distribution and control system (PDCS), electrical power system (EPS), and electric power generation system (EPGS).

  14. EPA Summaries and Reports on Several State and Local PM Control Measures

    EPA Pesticide Factsheets

    A sample of existing control measures and their effectiveness, along with recommendations for improvement, can help states develop better control measures for reducing PM2.5 in order to attain 2012 PM2.5 National Ambient Air Quality Standards (NAAQS).

  15. Toluene depletion in produced oil contributes to souring control in a field subjected to nitrate injection.

    PubMed

    Agrawal, Akhil; Park, Hyung Soo; Nathoo, Safia; Gieg, Lisa M; Jack, Thomas R; Miner, Kirk; Ertmoed, Ryan; Benko, Aaron; Voordouw, Gerrit

    2012-01-17

    Souring in the Medicine Hat Glauconitic C field, which has a low bottom-hole temperature (30 °C), results from the presence of 0.8 mM sulfate in the injection water. Inclusion of 2 mM nitrate to decrease souring results in zones of nitrate-reduction, sulfate-reduction, and methanogenesis along the injection water flow path. Microbial community analysis by pyrosequencing indicated dominant community members in each of these zones. Nitrate breakthrough was observed in 2-PW, a major water- and sulfide-producing well, after 4 years of injection. Sulfide concentrations at four other production wells (PWs) also reached zero, causing the average sulfide concentration in 14 PWs to decrease significantly. Interestingly, oil produced by 2-PW was depleted of toluene, the preferred electron donor for nitrate reduction. 2-PW and other PWs with zero sulfide produced 95% water and 5% oil. At 2 mM nitrate and 5 mM toluene, respectively, this represents an excess of electron acceptor over electron donor. Hence, continuous nitrate injection can change the composition of produced oil and nitrate breakthrough is expected first in PWs with a low oil to water ratio, because oil from these wells is treated on average with more nitrate than is oil from PWs with a high oil to water ratio.

  16. Executive summary

    NASA Technical Reports Server (NTRS)

    Ayon, Juan A.

    1992-01-01

    The Astrotech 21 Optical Systems Technology Workshop was held in Pasadena, California on March 6-8, 1991. The purpose of the workshop was to examine the state of Optical Systems Technology at the National Aeronautics Space Administration (NASA), and in industry and academia, in view of the potential Astrophysics mission set currently being considered for the late 1990's through the first quarter of the 21st century. The principal result of the workshop is this publication, which contains an assessment of the current state of the technology, and specific technology advances in six critical areas of optics, all necessary for the mission set. The workshop was divided into six panels, each of about a dozen experts in specific fields, representing NASA, industry, and academia. In addition, each panel contained expertise that spanned the spectrum from x-ray to submillimeter wavelengths. This executive summary contains the principal recommendations of each panel. The six technology panels and their chairs were: (1) Wavefront Sensing, Control, and Pointing, Thomas Pitts, Itek Optical Systems, A Division of Litton; (2) Fabrication, Roger Angel, Steward Observatory, University of Arizona; (3) Materials and Structures, Theodore Saito, Lawrence Livermore National Laboratory; (4) Optical Testing, James Wyant, WYKO Corporation; (5) Optical Systems Integrated Modeling, Robert R. Shannon, Optical Sciences Center, University of Arizona; and (6) Advanced Optical Instruments Technology, Michael Shao, Jet Propulsion Laboratory, California Institute of Technology. This Executive Summary contains the principal recommendations of each panel.

  17. Controllable all-optical stochastic logic gates and their delay storages based on the cascaded VCSELs with optical-injection

    NASA Astrophysics Data System (ADS)

    Zhong, Dongzhou; Luo, Wei; Xu, Geliang

    2016-09-01

    Using the dynamical properties of the polarization bistability that depends on the detuning of the injected light, we propose a novel approach to implement reliable all-optical stochastic logic gates in the cascaded vertical cavity surface emitting lasers (VCSELs) with optical-injection. Here, two logic inputs are encoded in the detuning of the injected light from a tunable CW laser. The logic outputs are decoded from the two orthogonal polarization lights emitted from the optically injected VCSELs. For the same logic inputs, under electro-optic modulation, we perform various digital signal processing (NOT, AND, NAND, XOR, XNOR, OR, NOR) in the all-optical domain by controlling the logic operation of the applied electric field. Also we explore their delay storages by using the mechanism of the generalized chaotic synchronization. To quantify the reliabilities of these logic gates, we further demonstrate their success probabilities. Project supported by the National Natural Science Foundation of China (Grant No. 61475120) and the Innovative Projects in Guangdong Colleges and Universities, China (Grant Nos. 2014KTSCX134 and 2015KTSCX146).

  18. Synchronized droplet size measurements for Coal-Water-Slurry (CWS) diesel sprays of an electronically-controlled fuel injection system

    NASA Astrophysics Data System (ADS)

    Kihm, K. D.; Terracina, D. P.; Payne, S. E.; Caton, J. A.

    Experiments were completed to study intermittent coal-water slurry (CWS) fuel sprays injected from an electronically-controlled accumulator injector system. A laser diffraction particle analyzing (LDPA) technique was used to measure the spray diameters (Sauter mean diameter, SMD) assuming the Rosin-Rammler two parameter model. In order to ensure an accurate synchronization of the measurement with the intermittent sprays, a new synchronization technique was developed using the light extinction signal as a triggering source for the data taking initiation. This technique allowed measurement of SMD's near the spray tip where the light extinction was low and the data were free from the multiscattering bias. Coal-water slurry fuel with 50% coal loading in mass containing 5 (mu)m mass median diameter coal particulates was considered. Injection pressures ranging from 28 to 110 MPa, two different nozzle orifice diameters, 0.2 ad 0.4 mm, and four axial measurement locations from 60 to 120 mm from the nozzle orifice were studied. Measurements were made for pressurized (2.0 MPa in gauge) and for ambient chamber conditions. The spray SMD showed an increase with the distance of the axial measurement location and with the ambient gas density, and showed a decrease with increasing injection pressure. A correlation of the Sauter mean diameter with the injection conditions was determined. The results were also compared with previous SMD correlations that were available only for diesel fuel sprays.

  19. A randomised control trial to evaluate the efficacy of autologous blood injection versus local corticosteroid injection for treatment of lateral epicondylitis

    PubMed Central

    Dojode, C. M.

    2012-01-01

    Objectives Local corticosteroid infiltration is a common practice of treatment for lateral epicondylitis. In recent studies no statistically significant or clinically relevant results in favour of corticosteroid injections were found. The injection of autologous blood has been reported to be effective for both intermediate and long-term outcomes. It is hypothesised that blood contains growth factors, which induce the healing cascade. Methods A total of 60 patients were included in this prospective randomised study: 30 patients received 2 ml autologous blood drawn from contralateral upper limb vein + 1 ml 0.5% bupivacaine, and 30 patients received 2 ml local corticosteroid + 1 ml 0.5% bupivacaine at the lateral epicondyle. Outcome was measured using a pain score and Nirschl staging of lateral epicondylitis. Follow-up was continued for total of six months, with assessment at one week, four weeks, 12 weeks and six months. Results The corticosteroid injection group showed a statistically significant decrease in pain compared with autologous blood injection group in both visual analogue scale (VAS) and Nirschl stage at one week (both p < 0.001) and at four weeks (p = 0.002 and p = 0.018, respectively). At the 12-week and six-month follow-up, autologous blood injection group showed statistically significant decrease in pain compared with corticosteroid injection group (12 weeks: VAS p = 0.013 and Nirschl stage p = 0.018; six months: VAS p = 0.006 and Nirschl p = 0.006). At the six-month final follow-up, a total of 14 patients (47%) in the corticosteroid injection group and 27 patients (90%) in autologous blood injection group were completely relieved of pain. Conclusions Autologous blood injection is efficient compared with corticosteroid injection, with less side-effects and minimum recurrence rate. PMID:23610690

  20. The effect of switched array battery charge control on CRRES spacecraft: 3 + month data summary

    NASA Technical Reports Server (NTRS)

    Olbert, Phil

    1991-01-01

    The following topics are covered in viewgraph format: Combined Release and Radiation Effects Satellite (CRRES) orbit parameters; battery charge control; battery description; battery current and voltage output during one orbit; and battery reconditioning discharge profile.

  1. Summary of Research on Reliability Criteria-Based Flight System Control

    NASA Technical Reports Server (NTRS)

    Wu, N. Eva; Belcastro, Christine (Technical Monitor)

    2002-01-01

    This paper presents research on the reliability assessment of adaptive flight control systems. The topics include: 1) Overview of Project Focuses; 2) Reliability Analysis; and 3) Design for Reliability. This paper is presented in viewgraph form.

  2. QUALITY ASSURANCE AND QUALITY CONTROL FOR WASTE CONTAINMENT FACILITIES. Project Summary

    EPA Science Inventory

    It is generally agreed that both quality assurance (QA) and quality control (QC) are essential to the proper installation and eventual performance of environmentally safe and secure waste containment systems. Even further, there are both manufacturing and construction aspects to...

  3. Preventing ventilator-associated pneumonia: An executive summary of the Association for Professionals in Infection Control and Epidemiology, Inc, Elimination Guide.

    PubMed

    Rebmann, Terri; Greene, Linda R

    2010-10-01

    This article is an executive summary of the Association for Professionals in Infection Control and Epidemiology, Inc, Elimination Guide for ventilator-associated pneumonia. Infection preventionists are encouraged to obtain the original, full-length Association for Professionals in Infection Control and Epidemiology, Inc, Elimination Guide for more thorough coverage of ventilator-associated pneumonia prevention.

  4. Summary of semi-initiative and initiative control automobile engine vibration

    NASA Astrophysics Data System (ADS)

    Qu, Wei; Qu, Zhou

    2009-07-01

    Engine vibration accounts for around 55% of automobile vibration, separating the engine vibration from transmitting to automobile to the utmost extent is significant for improving NVH performance. Semi-initiative and initiative control of engine vibration is one of the hot spots of technical research in domestic and foreign automobile industry, especially luxury automobiles which adopt this technology to improve amenity and competitiveness. This article refers to a large amount of domestic and foreign related materials, fully introduces the research status of semi-initiative and initiative control suspension of engine vibration suspension and many kinds of structural style, and provides control policy and method of semi-initiative and initiative control suspension system. Compare and analyze the structural style of semi-initiative and initiative control and merits and demerits of current structures of semi-initiative and initiative control of mechanic electrorheological, magnetorheological, electromagnetic actuator, piezoelectric ceramics, electrostriction material, pneumatic actuator etc. Models of power assembly mounting system was classified.Calculation example indicated that reasonable selection of engine mounting system parameters is useful to reduce engine vibration transmission and to increase ride comfort. Finally we brought forward semi-initiative and initiative suspension which might be applied for automobiles, and which has a promising future.

  5. Control of fire blight (Erwinia amylovora) on apple trees with trunk-injected plant resistance inducers and antibiotics and assessment of induction of pathogenesis-related protein genes.

    PubMed

    Aćimović, Srđan G; Zeng, Quan; McGhee, Gayle C; Sundin, George W; Wise, John C

    2015-01-01

    Management of fire blight is complicated by limitations on use of antibiotics in agriculture, antibiotic resistance development, and limited efficacy of alternative control agents. Even though successful in control, preventive antibiotic sprays also affect non-target bacteria, aiding the selection for resistance which could ultimately be transferred to the pathogen Erwinia amylovora. Trunk injection is a target-precise pesticide delivery method that utilizes tree xylem to distribute injected compounds. Trunk injection could decrease antibiotic usage in the open environment and increase the effectiveness of compounds in fire blight control. In field experiments, after 1-2 apple tree injections of either streptomycin, potassium phosphites (PH), or acibenzolar-S-methyl (ASM), significant reduction of blossom and shoot blight symptoms was observed compared to water injected control trees. Overall disease suppression with streptomycin was lower than typically observed following spray applications to flowers. Trunk injection of oxytetracycline resulted in excellent control of shoot blight severity, suggesting that injection is a superior delivery method for this antibiotic. Injection of both ASM and PH resulted in the significant induction of PR-1, PR-2, and PR-8 protein genes in apple leaves indicating induction of systemic acquired resistance (SAR) under field conditions. The time separating SAR induction and fire blight symptom suppression indicated that various defensive compounds within the SAR response were synthesized and accumulated in the canopy. ASM and PH suppressed fire blight even after cessation of induced gene expression. With the development of injectable formulations and optimization of doses and injection schedules, the injection of protective compounds could serve as an effective option for fire blight control.

  6. Control of fire blight (Erwinia amylovora) on apple trees with trunk-injected plant resistance inducers and antibiotics and assessment of induction of pathogenesis-related protein genes

    PubMed Central

    Aćimović, Srđan G.; Zeng, Quan; McGhee, Gayle C.; Sundin, George W.; Wise, John C.

    2015-01-01

    Management of fire blight is complicated by limitations on use of antibiotics in agriculture, antibiotic resistance development, and limited efficacy of alternative control agents. Even though successful in control, preventive antibiotic sprays also affect non-target bacteria, aiding the selection for resistance which could ultimately be transferred to the pathogen Erwinia amylovora. Trunk injection is a target-precise pesticide delivery method that utilizes tree xylem to distribute injected compounds. Trunk injection could decrease antibiotic usage in the open environment and increase the effectiveness of compounds in fire blight control. In field experiments, after 1–2 apple tree injections of either streptomycin, potassium phosphites (PH), or acibenzolar-S-methyl (ASM), significant reduction of blossom and shoot blight symptoms was observed compared to water injected control trees. Overall disease suppression with streptomycin was lower than typically observed following spray applications to flowers. Trunk injection of oxytetracycline resulted in excellent control of shoot blight severity, suggesting that injection is a superior delivery method for this antibiotic. Injection of both ASM and PH resulted in the significant induction of PR-1, PR-2, and PR-8 protein genes in apple leaves indicating induction of systemic acquired resistance (SAR) under field conditions. The time separating SAR induction and fire blight symptom suppression indicated that various defensive compounds within the SAR response were synthesized and accumulated in the canopy. ASM and PH suppressed fire blight even after cessation of induced gene expression. With the development of injectable formulations and optimization of doses and injection schedules, the injection of protective compounds could serve as an effective option for fire blight control. PMID:25717330

  7. Independent Auditors Report on the FY 2015 DoD Performance Summary Report of the Funds Obligated for National Drug Control Program Activities

    DTIC Science & Technology

    2016-01-29

    for National Drug Control Program Activities Mission Our mission is to provide independent, relevant, and timely oversight of the Department of...THE ARMY SUBJECT: Independent Auditor’s Report on the FY 2015 DoD Performance Summary Report of the Funds Obligated for National Drug Control Program...Activities (Report No. DODIG-2016-042) The Office of National Drug Control Policy (ONDCP) Circular, “Accounting of Drug Control Funding and

  8. Development and flight evaluation of an augmented stability active controls concept: Executive summary

    NASA Technical Reports Server (NTRS)

    Guinn, W. A.

    1982-01-01

    A pitch active control system (PACS) was developed and flight tested on a wide body jet transport (L-1011) with a flying horizontal stabilizer. Two dual channel digital computers and the associated software provide command signals to a dual channel series servo which controls the stabilizer power actuators. Input sensor signals to the computer are pitch rate, column trim position, and dynamic pressure. Control laws are given for the PACS and the system architecture is defined. Discussions are given regarding piloted flight simulation and vehicle system simulation and vehicle system simulation tests that are performed to verify control laws and system operation prior to installation on the aircraft. Modifications to the basic aircraft included installation of the PACS, addition of a c.g. management system to provide a c.g. range from 25 to 39% mac, and downrigging of the geared elevator to provide the required nose down control authority for aft c.g. flight test conditions. Three pilots used the Cooper-Harper Rating Scale to judge flying qualities of the aircraft with PACS on and off. The handling qualities with the c.g. at 39% mac (41% stability margin) and PACS operating were judged to be as good as the handling qualities with the c.g. at 25% mac (+15% stability margin) and PACS off.

  9. A summary of research and progress on carbon monoxide exposure control solutions on houseboats.

    PubMed

    Hall, Ronald M; Earnest, G Scott; Hammond, Duane R; Dunn, Kevin H; Garcia, Alberto

    2014-01-01

    Investigations of carbon monoxide (CO-related poisonings and deaths on houseboats were conducted by the Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. These investigations measured hazardous CO concentrations on and around houseboats that utilize gasoline-powered generators. Engineering control devices were developed and tested to mitigate this deadly hazard. CO emissions were measured using various sampling techniques which included exhaust emission analyzers, detector tubes, evacuated containers (grab air samples analyzed by a gas chromatograph), and direct-reading CO monitors. CO results on houseboats equipped with gasoline-powered generators without emission controls indicated hazardous CO concentrations exceeding immediately dangerous to life and health (IDLH) levels in potentially occupied areas of the houseboat. Air sample results on houseboats that were equipped with engineering controls to remove the hazard were highly effective and reduced CO levels by over 98% in potentially occupied areas. The engineering control devices used to reduce the hazardous CO emissions from gasoline-powered generators on houseboats were extremely effective at reducing CO concentrations to safe levels in potentially occupied areas on the houseboats and are now beginning to be widely used.

  10. Asymmetrical booster ascent guidance and control system design study. Volume 1: Summary. [space shuttle development

    NASA Technical Reports Server (NTRS)

    Williams, F. E.; Lemon, R. S.; Jaggers, R. F.; Wilson, J. L.

    1974-01-01

    Dynamics and control, stability, and guidance analyses are summarized for the asymmetrical booster ascent guidance and control system design studies, performed in conjunction with space shuttle planning. The mathematical models developed for use in rigid body and flexible body versions of the NASA JSC space shuttle functional simulator are briefly discussed, along with information on the following: (1) space shuttle stability analysis using equations of motion for both pitch and lateral axes; (2) the computer program used to obtain stability margin; and (3) the guidance equations developed for the space shuttle powered flight phases.

  11. Understanding and Quantifying Controls of Arsenic Mobility during Deepwell Re-injection of CSG Waters

    NASA Astrophysics Data System (ADS)

    Davis, J. A.; Rathi, B.; Prommer, H.; Donn, M.; Siade, A. J.; Berg, M.

    2014-12-01

    In Australia, the injection of reverse-osmosis treated production water from coal seams into the surrounding, deep aquifers may provide the most viable method to dispose of large quantities of production water. The geochemical disequilibrium between the injectant water composition and the target aquifer can potentially drive a range of water-sediment interactions that must be clearly understood and quantified in order to anticipate and manage future water quality changes at both the local and regional scale. In this study, we use a multi-scale geochemical characterisation of a proposed reinjection site in combination with geochemical/reactive transport modeling to understand and predict the long-term fate of arsenic; and explore means for suitably mitigating an undesired increase of naturally occurring arsenic concentrations. We use a series of arsenic sorption experiments with the aquifer material from an injection trial site in Queensland, Australia to quantify As sorption/desorption from mineral surfaces in response to changes in site-specific geochemical conditions. Batch experiments with arsenite were performed under anoxic conditions to replicate the highly reducing in-situ conditions. The results showed significant arsenic mobility at pH >8. Competitive sorption effects with phosphate and the impact of varying temperatures were also tested in batch mode. A site-specific general composite (GC) surface complexation model (SCM) was derived through inverse geochemical modeling, i.e., selection of appropriate surface complexation reactions and optimization of sorption constants. The SCM was subsequently tested and further improved during the interpretation of data from column flow-through experiments and from a field injection trial. Eventually the uncertainty associated with estimates of sorption constants was addressed and the effects of this uncertainty on field-scale model predictions were analyzed.

  12. Quality Control of Injection Molded Eyewear by Non-Contact Deflectometry

    NASA Astrophysics Data System (ADS)

    Speck, A.; Zelzer, B.; Langenbucher, A.; Eppig, T.

    2014-07-01

    Occupational eye wear such as safety spectacles are manufactured by injection molding techniques. Testing of the assembled safety spectacle lenses in transmission is state of the art, but there is a lack of surface measurement systems for occupational safety lenses. The purpose of this work was to validate a deflectometric setup for topography measurement, detection of defects and visualization of the polishing quality, e.g. casting indentations or impressions, for the production process of safety spectacles. The setup is based on a customized stereo phase measuring deflectometer (PMD), equipped with 3 cameras with f'1,2 = 16 mm and f'3 = 8.5 mm and a specified measurement uncertainty of ± 3 μm. Sixteen plastic lenses and 8 corresponding injection molds from 4 parallel cavities were used for validation of the deflectometer. For comparison an interferometric method and a reference standard (< λ/10 super polished) was used. The accuracy and bias with a spherical safety spectacle sample was below 1 μm, according to DIN ISO 5725-2.2002-12. The repeatability was 2.1 μm and 35.7 μm for a blind radius fit. In conclusion, the PMD technique is an appropriate tool for characterizing occupational safety spectacle and injections mold surfaces. With the presented setup we were able to quantify the surface quality. This can be useful and may optimize the quality of the end product, in addition to standardized measuring systems in transmission.

  13. Summary report on beam and radiation generation, monitoring and control (working group 6).

    SciTech Connect

    Power, J. G.; Gordon, D. F.; High Energy Physics; Naval Research Lab.

    2009-01-01

    The discussions of the working group on beam and radiation generation, monitoring, and control (working group 6) at the 2008 advanced accelerator concepts workshop are summarized. The discussions concerned electron injectors, phase space manipulation, beam diagnostics, pulse train generation, intense beam physics, and radiation generation.

  14. Workshop on arms control and security in the Middle East II summary report

    SciTech Connect

    Chrzanowski, P.L.

    1994-04-01

    The Middle East peace process is now moving more rapidly than ever before. Many actors in the region have displayed a newfound willingness to adopt innovative approaches to resolving persistent conflicts. The end of the Cold War, the accord signed between Israel and the PLO in September 1993, and other recent hopeful developments in the bilateral and multilateral talks have opened the door to real progress in regional security and arms control. The door may quickly shut, however, if promising signs are not translated into concrete, practical, and verifiable agreements. To complement the ongoing negotiations and help sustain the momentum of the Middle East peace process, the Institute on Global Conflict and Cooperation (IGCC) and the Institute of International Relations, co-sponsored a Workshop on Arms Control and Security in the Middle East in Delphi, Greece, in January 1994. Participants in the Delphi workshop were current and former government officials, veteran arms control negotiators, military officers, and leading nongovernmental specialists on arms control and regional security issues from Arab states, Israel, the United States, Europe, and Russia. To facilitate frank discussions and the free exchange of ideas, the conference was held in a private, informal setting, and all discussions at the meeting were off the record. The workshop gave Arab and Israeli participants an opportunity to draw upon the expertise that American, European, and Russian experts have gained through research and development efforts and negotiations between and within governments on arms control issues. At the same time, Arab and Israeli experts voiced their ideas, perspectives, and concerns to each other and to the participants from outside the Middle East. This report summarizes the main points of agreement and the major areas of controversy that came to the fore at the Delphi conference.

  15. NRRI summary of Florida Public Service Commission: Fraud control policies of seven major Florida utilities

    SciTech Connect

    1995-12-31

    The Florida Public Service Commission (PSC) Staff recently completed an audit of fraud control policies and programs at the State`s largest regulated electric and local telephone utilities. The purpose of the audit was to examine the ability of Florida`s largest regulated utilities to deter, detect, and resolve occurrences of fraud. The Staff audited the state`s seven largest regulated electric and local telephone utilities: Florida Power Corporation, Florida Power and Light, Gulf Power Corporation, Tampa Electric Company, GTE-Florida, BellSouth Telecommunications (Southern Bell), and Sprint United/Centel. The audit scope was limited to fraudulent acts committed by employees, contractors, suppliers, or agents of the seven utilities. Information regarding the utilities` fraud control policies and programs was obtained through surveys, document requests, and interviews with managers and officers.

  16. Summary of stability and control characteristics of the XB-70 airplane

    NASA Technical Reports Server (NTRS)

    Wolowicz, C. H.; Yancey, R. B.

    1973-01-01

    The stability and control characteristics of the XB-70 airplane were evaluated for Mach numbers up to 3.0 and altitudes up to 21,300 meters (70,000 feet). The airplane's inherent longitudinal characteristics proved to be generally satisfactory. In the lateral-directional modes, the airplane was characterized by light wheel forces, low static directional stability beyond approximately 2 deg of sideslip, adverse yaw response to aileron inputs throughout the entire Mach number range, and negative effective dihedral with wingtips full down. At subsonic Mach numbers, with the flight augmentation control system off, the light wheel forces and adverse yaw response to aileron inputs caused the pilots to minimize use of the ailerons. At supersonic Mach numbers, with the augmentation system off, the adverse yaw due to aileron and the negative effective dihedral were conducive to pilot-induced oscillations.

  17. Ada Compiler Validation Summary Report: Control Data Corporation, CYBER 180-830 (Host and Target)

    DTIC Science & Technology

    1988-01-22

    1988 to 22 Jan 1989 Control Data Corporation,CYBER 180 Ada Compiler, Version 1.0, CYBER 180-830 (Host and 6. PERFORM’NG ORG . REPORT NUMBER % Target). PO_...Compiler, Version: 1.0 Host Architecture ISA: CYBER 180 - 830 OS&VER #: NOS/VE LEVEL 688 . "* 0’ \\.1: Implementor’s Deol Iara -t, ln I, the

  18. Controlled drug release from a novel injectable biodegradable microsphere/scaffold composite based on poly(propylene fumarate).

    PubMed

    Kempen, Diederik H R; Lu, Lichun; Kim, Choll; Zhu, Xun; Dhert, Wouter J A; Currier, Bradford L; Yaszemski, Michael J

    2006-04-01

    The ideal biomaterial for the repair of bone defects is expected to have good mechanical properties, be fabricated easily into a desired shape, support cell attachment, allow controlled release of bioactive factors to induce bone formation, and biodegrade into nontoxic products to permit natural bone formation and remodeling. The synthetic polymer poly(propylene fumarate) (PPF) holds great promise as such a biomaterial. In previous work we developed poly(DL-lactic-co-glycolic acid) (PLGA) and PPF microspheres for the controlled delivery of bioactive molecules. This study presents an approach to incorporate these microspheres into an injectable, porous PPF scaffold. Model drug Texas red dextran (TRD) was encapsulated into biodegradable PLGA and PPF microspheres at 2 microg/mg microsphere. Five porous composite formulations were fabricated via a gas foaming technique by combining the injectable PPF paste with the PLGA or PPF microspheres at 100 or 250 mg microsphere per composite formulation, or a control aqueous TRD solution (200 microg per composite). All scaffolds had an interconnected pore network with an average porosity of 64.8 +/- 3.6%. The presence of microspheres in the composite scaffolds was confirmed by scanning electron microscopy and confocal microscopy. The composite scaffolds exhibited a sustained release of the model drug for at least 28 days and had minimal burst release during the initial phase of release, as compared to drug release from microspheres alone. The compressive moduli of the scaffolds were between 2.4 and 26.2 MPa after fabrication, and between 14.9 and 62.8 MPa after 28 days in PBS. The scaffolds containing PPF microspheres exhibited a significantly higher initial compressive modulus than those containing PLGA microspheres. Increasing the amount of microspheres in the composites was found to significantly decrease the initial compressive modulus. The novel injectable PPF-based microsphere/scaffold composites developed in this study

  19. Evaluation of laminar flow control systems for subsonic commercial transport aircraft: Executive summary

    NASA Technical Reports Server (NTRS)

    Pearce, W. E.

    1982-01-01

    An evaluation was made of laminar flow control (LFC) system concepts for subsonic commercial transport aircraft. Configuration design studies, performance analyses, fabrication development, structural testing, wind tunnel testing, and contamination-avoidance techniques were included. As a result of trade studies, a configuration with LFC on the upper wing surface only, utilizing an electron beam-perforated suction surface, and employing a retractable high-lift shield for contamination avoidance, was selected as the most practical LFC system. The LFC aircraft was then compared with an advanced turbulent aircraft designed for the same mission. This comparison indicated significant fuel savings.

  20. Summary of Altitude Pulse Testing of a 100-lbf L02/LCH4 Reaction Control Engine

    NASA Technical Reports Server (NTRS)

    Marshall, William M.; Kleinhenz, Julie E.

    2011-01-01

    Recently, liquid oxygen-liquid methane (LO2/LCH4) has been considered as a potential "green" propellant alternative for future exploration missions. The Propulsion and Cryogenic Advanced Development (PCAD) project has been tasked by NASA to develop this propulsion combination to enable safe and cost effective exploration missions. To date, limited experience with such combinations exist, and as a result a comprehensive test program is critical to demonstrating the viability of implementing such a system. The NASA Glenn Research Center has conducted a test program of a 100-lbf (445-N) reaction control engine (RCE) at the center s Altitude Combustion Stand (ACS), focusing on altitude testing over a wide variety of operational conditions. The ACS facility includes a unique propellant conditioning feed system (PCFS) which allows precise control of propellant inlet conditions to the engine. Engine performance as a result of these inlet conditions was examined extensively during the test program. This paper is a companion to the previous specific impulse testing paper, and discusses the pulsed mode operation portion of testing, with a focus on minimum impulse bit (I-bit) and repeatable pulse performance. The engine successfully demonstrated target minimum impulse bit performance at all conditions, as well as successful demonstration of repeatable pulse widths. Some anomalous conditions experienced during testing are also discussed, including a double pulse phenomenon which was not noted in previous test programs for this engine.

  1. Thermal Control Method for High-Current Wire Bundles by Injecting a Thermally Conductive Filler

    NASA Technical Reports Server (NTRS)

    Rodriguez-Ruiz, Juan; Rowles, Russell; Greer, Greg

    2011-01-01

    A procedure was developed to inject thermal filler material (a paste-like substance) inside the power wire bundle coming from solar arrays. This substance fills in voids between wires, which enhances the heat path and reduces wire temperature. This leads to a reduced amount of heat generated. This technique is especially helpful for current and future generation high-power spacecraft (1 kW or more), because the heat generated by the power wires is significant enough to cause unacceptable overheating to critical components that are in close contact with the bundle.

  2. Retrieving treatment and control proportions from incomplete summary data in meta-analysis.

    PubMed

    Olkin, Ingram

    2012-09-01

    One of the vexing problems often encountered when combining the results of independent studies in a meta-analysis is that the data provided in individual studies are incomplete. Some studies may provide only a risk difference and others only an odds ratio. Of course, if the proportions for treatment and control are reported, then the meta-analyst can carry out a variety of analyses, such as fixed or random effect estimates. Excluding studies with incomplete data carries a risk and should be avoided if it is possible to retrieve the original proportions. Inclusion criteria in some meta-analyses may require that studies contain full data. This requirement can be relaxed if the original data can be retrieved. Copyright © 2012 John Wiley & Sons, Ltd.

  3. A Randomized Controlled Clinical Trial to Determine the Effectiveness of Caudal Epidural Steroid Injection in Lumbosacral Sciatica

    PubMed Central

    Chowdhery, Abhishek

    2017-01-01

    Introduction Caudal epidural steroid injection have been a part of nonsurgical management of lumbosacral sciatica since last half a century but various randomized controlled trials fail to provide convincing evidence in favour of its effectiveness. Aim To assess the efficacy of caudal epidural steroid injection in patients of lumbosacral sciatica in comparison to placebo. Materials and Methods The study consisted of patients of sciatica caused by lumbosacral disc prolapse (observed on Magnetic Resonance Imaging (MRI) scan). Caudal epidural injections of 80 mg methyl prednisolone were injected in 47 patients in one group. The other group consisted of 46 patients who were injected isotonic saline as placebo. Self-evaluation was the main judgment criterion at 4th week using a descriptive four item scale (recovery, marked improvement, slight improvement, or worse). Patients rating the improvement as “recovery” or “marked improvement” were considered as success. Patients rating the improvement as “slight improvement” or “worse” were considered as failure. Only paracetamol were authorized and patients requiring Non Steroidal Anti-inflammatory Drugs (NSAIDs) before 4th week were also considered as failure. Results On analysis per protocol, at 4 weeks, the two groups differed significantly with respect to the primary outcome: among the 93 patients, 8/46 (17%) in the placebo group and 32/47 (68%) in the steroid group (p=0.000) were considered as success (difference 50.7%; 95% CI for the difference 33.4 to 67.99). But at the end of the study (week 12) there was no significant difference in primary outcome between the groups: 22/46 (48%) patients in the placebo group and 28/47 (60%) in the steroid group (p=0.25) were considered as success (difference 11.8%; 95% CI for the difference -8.38 to 31.9). Conclusion Caudal epidural steroid injections provide no additional improvement over placebo in the long term natural history of lumbosacral sciatica. However, it

  4. International Nosocomial Infection Control Consortium (INICC) report, data summary for 2003-2008, issued June 2009.

    PubMed

    Rosenthal, Victor D; Maki, Dennis G; Jamulitrat, Silom; Medeiros, Eduardo A; Todi, Subhash Kumar; Gomez, David Yepes; Leblebicioglu, Hakan; Abu Khader, Ilham; Miranda Novales, María Guadalupe; Berba, Regina; Ramírez Wong, Fernando Martín; Barkat, Amina; Pino, Osiel Requejo; Dueñas, Lourdes; Mitrev, Zan; Bijie, Hu; Gurskis, Vaidotas; Kanj, S S; Mapp, Trudell; Hidalgo, Rosalía Fernández; Ben Jaballah, Nejla; Raka, Lul; Gikas, Achilleas; Ahmed, Altaf; Thu, Le Thi Anh; Guzmán Siritt, María Eugenia

    2010-03-01

    We report the results of the International Infection Control Consortium (INICC) surveillance study from January 2003 through December 2008 in 173 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study, using Centers for Disease Control and Prevention (CDC) US National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infection, we collected prospective data from 155,358 patients hospitalized in the consortium's hospital ICUs for an aggregate of 923,624 days. Although device utilization in the developing countries' ICUs was remarkably similar to that reported from US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were markedly higher in the ICUs of the INICC hospitals: the pooled rate of central venous catheter (CVC)-associated bloodstream infections (BSI) in the INICC ICUs, 7.6 per 1000 CVC-days, is nearly 3-fold higher than the 2.0 per 1000 CVC-days reported from comparable US ICUs, and the overall rate of ventilator-associated pneumonia (VAP) was also far higher, 13.6 versus 3.3 per 1000 ventilator-days, respectively, as was the rate of catheter-associated urinary tract infection (CAUTI), 6.3 versus 3.3 per 1000 catheter-days, respectively. Most strikingly, the frequencies of resistance of Staphylococcus aureus isolates to methicillin (MRSA) (84.1% vs 56.8%, respectively), Klebsiella pneumoniae to ceftazidime or ceftriaxone (76.1% vs 27.1%, respectively), Acinetobacter baumannii to imipenem (46.3% vs 29.2%, respectively), and Pseudomonas aeruginosa to piperacillin (78.0% vs 20.2%, respectively) were also far higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 23.6% (CVC-associated bloodstream infections) to 29.3% (VAP).

  5. International Nosocomial Infection Control Consortium report, data summary for 2002-2007, issued January 2008.

    PubMed

    Rosenthal, Victor D; Maki, Dennis G; Mehta, Ajita; Alvarez-Moreno, Carlos; Leblebicioglu, Hakan; Higuera, Francisco; Cuellar, Luis E; Madani, Naoufel; Mitrev, Zan; Dueñas, Lourdes; Navoa-Ng, Josephine Anne; Garcell, Humberto Guanche; Raka, Lul; Hidalgo, Rosalía Fernández; Medeiros, Eduardo A; Kanj, Souha S; Abubakar, Salisu; Nercelles, Patricio; Pratesi, Ricardo Diez

    2008-11-01

    We report the results of an International Nosocomial Infection Control Consortium (INICC) surveillance study from 2002 through 2007 in 98 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study, using Centers for Disease Control and Prevention (CDC) National Nosocomial Infections Surveillance System (NNIS) definitions for device-associated health care-associated infection, we collected prospective data from 43,114 patients hospitalized in the Consortium's hospital ICUs for an aggregate of 272,279 days. Although device utilization in the INICC ICUs was remarkably similar to that reported from US ICUs in the CDC's National Healthcare Safety Network, rates of device-associated nosocomial infection were markedly higher in the ICUs of the INICC hospitals: the pooled rate of central line-associated bloodstream infections (CLABs) in the INICC ICUs, 9.2 per 1000 CL-days, is nearly 3-fold higher than the 2.4-5.3 per 1000 CL-days reported from comparable US ICUs, and the overall rate of ventilator-associated pneumonia was also far higher, 19.5 vs 1.1-3.6 per 1000 ventilator-days, as was the rate of catheter-associated urinary tract infection, 6.5 versus 3.4-5.2 per 1000 catheter-days. Most strikingly, the frequencies of resistance of Staphylococcus aureus isolates to methicillin (MRSA) (80.8% vs 48.1%), Enterobacter species to ceftriaxone (50.8% vs 17.8%), and Pseudomonas aeruginosa to fluoroquinolones (52.4% vs 29.1%) were also far higher in the Consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 14.3% (CLABs) to 27.5% (ventilator-associated pneumonia).

  6. Estimates of increased black carbon emissions from electrostatic precipitators during powdered activated carbon injection for mercury emissions control.

    PubMed

    Clack, Herek L

    2012-07-03

    The behavior of mercury sorbents within electrostatic precipitators (ESPs) is not well-understood, despite a decade or more of full-scale testing. Recent laboratory results suggest that powdered activated carbon exhibits somewhat different collection behavior than fly ash in an ESP and particulate filters located at the outlet of ESPs have shown evidence of powdered activated carbon penetration during full-scale tests of sorbent injection for mercury emissions control. The present analysis considers a range of assumed differential ESP collection efficiencies for powdered activated carbon as compared to fly ash. Estimated emission rates of submicrometer powdered activated carbon are compared to estimated emission rates of particulate carbon on submicrometer fly ash, each corresponding to its respective collection efficiency. To the extent that any emitted powdered activated carbon exhibits size and optical characteristics similar to black carbon, such emissions could effectively constitute an increase in black carbon emissions from coal-based stationary power generation. The results reveal that even for the low injection rates associated with chemically impregnated carbons, submicrometer particulate carbon emissions can easily double if the submicrometer fraction of the native fly ash has a low carbon content. Increasing sorbent injection rates, larger collection efficiency differentials as compared to fly ash, and decreasing sorbent particle size all lead to increases in the estimated submicrometer particulate carbon emissions.

  7. Simultaneous determination of eight active components in Houttuynia cordata injection and its quality control in productive process.

    PubMed

    Ji, Wei; Bi, Kaishun; Chen, Qianqian; Jiang, Lingyan; Liang, Ke; Li, Qing

    2011-11-01

    A simple, reliable and effective gas chromatography coupled with flame ionization detection method was developed for the simultaneous determination of eight components (α-pinene, β-pinene, myrcene, limonene, terpinen-4-ol, α-terpineol, bornyl acetate and methyl-n-nonylketone) in Chinese medicine Houttuynia cordata and its injection. The chromatographic separation of all eight components, including undecylene as internal standard was performed on a DB-1 column (30 m×0.25 mm, 0.25 μm). Excellent linear behaviors including herb and injection over the investigated concentration ranges were observed with the values of r(2) higher than 0.9990 for all analytes. Satisfactory intra-day and inter-day precisions were achieved with RSD less than 2% and the average recoveries for all analytes at three different concentrations obtained were in the range of 93.4-104.4%, with RSD ranging from 1.3 to 4.1%. The proposed method was successfully applied in the simultaneous determination of these active components in H. cordata and H. cordata injection (HCI), including the intermediate product of HCI in productive process, from different pharmaceutical factories and different production batches, indicating that the method in this paper was particularly suitable for the routine analysis of HCI and its quality control in productive process.

  8. Controlled injection of a liquid into ultra-high vacuum: Submonolayers of adenosine triphosphate deposited on Cu(110)

    NASA Astrophysics Data System (ADS)

    Sobrado, J. M.; Martín-Gago, J. A.

    2016-10-01

    We have combined a fast-valve device with vacuum technology for implementing a new method that allows introducing liquid solutions in an ultra-high vacuum chamber in the form of very small droplets. This technical development allows the easy deposition of (bio) organic molecules or small nanoparticles on a surface in a fully in-situ process, avoiding possible contamination due to the handle of the material. Moreover, our experimental set-up is suitable for any liquid and does not require any voltage application as in electrospray. We can easily change the operating regime from liquid droplet injection to the formation of a highly dispersive jet of micro-droplets by exclusively adjusting external parameters. Due to the nature of the injection process, the operational protocol makes possible the deposition of delicate molecular species that cannot be thermally sublimated. In particular, we have used this system to study the deposition of adenosine triphosphate on Cu(110). The structure of the layer was analyzed by X-ray photoemission spectroscopy and the evolution of the signal from the deposited molecule with the number of injections indicates that the molecular coverage can be controlled with submonolayer precision.

  9. Efficacy of imidacloprid, trunk-injected into Acer platanoides, for control of adult Asian longhorned beetles (Coleoptera: Cerambycidae).

    PubMed

    Ugine, Todd A; Gardescu, Sana; Lewis, Phillip A; Hajek, Ann E

    2012-12-01

    Feeding experiments with Asian longhorned beetles (Anoplophora glabripennis (Motschulsky)) in a quarantine laboratory were used to assess the effectiveness of imidacloprid in reducing adult fecundity and survival. The beetles were fed twigs and leaves cut between June-September 2010 from Norway maples (Acer platanoides L.) in the beetle-infested area of Worcester, MA. Treated trees had been trunk-injected once with imidacloprid in spring 2010 under the U.S. Department of Agriculture-Animal and Plant Health Inspection Service operational eradication program. The 21 d LC50 value for adult beetles feeding on twig bark from imidacloprid-injected trees was 1.3 ppm. Adult reproductive output and survival were significantly reduced when beetles fed on twig bark or leaves from treated trees. However, results varied widely, with many twig samples having no detectable imidacloprid and little effect on the beetles. When twigs with > 1 ppm imidacloprid in the bark were fed to mated beetles, the number of larvae produced was reduced by 94% and median adult survival was reduced to 14 d. For twigs with < 1 ppm imidacloprid, 68% of reproductively mature mated beetles survived 21 d and 56% of unmated recently eclosed beetles survived 42 d. For twigs with < 1 ppm, beetles ingested an average of 30 nanograms of imidacloprid per day. Bark consumption was reduced at higher imidacloprid levels (> 1 ppm). When given a choice of control twigs and twigs from injected trees, beetles did not show a strong preference.

  10. Reductions in HIV/STI Incidence and Sharing of Injection Equipment among Female Sex Workers Who Inject Drugs: Results from a Randomized Controlled Trial

    PubMed Central

    Strathdee, Steffanie A.; Abramovitz, Daniela; Lozada, Remedios; Martinez, Gustavo; Rangel, Maria Gudelia; Vera, Alicia; Staines, Hugo; Magis-Rodriguez, Carlos; Patterson, Thomas L.

    2013-01-01

    Background We evaluated brief combination interventions to simultaneously reduce sexual and injection risks among female sex workers who inject drugs (FSW-IDUs) in Tijuana and Ciudad Juarez, Mexico during 2008–2010, when harm reduction coverage was expanding rapidly in Tijuana, but less so in Juarez. Methods FSW-IDUs ≥18 years reporting sharing injection equipment and unprotected sex with clients within the last month participated in a randomized factorial trial comparing four brief, single-session conditions combining either an interactive or didactic version of a sexual risk intervention to promote safer sex in the context of drug use, and an injection risk intervention to reduce sharing of needles/injection paraphernalia. Women underwent quarterly interviews and testing for HIV, syphilis, gonorrhea, Chlamydia and Trichomonas, blinding interviewers and assessors to assignment. Poisson regression with robust variance estimation and repeated measures ordinal logistic regression examined effects on combined HIV/STI incidence and receptive needle sharing frequency. Findings Of 584 initially HIV-negative FSW-IDUs, retention was ≥90%. After 12 months, HIV/STI incidence decreased >50% in the interactive vs. didactic sex intervention (Tijuana:AdjRR:0.38,95% CI:0.16–0.89; Juarez: AdjRR:0.44,95% CI:0.19–0.99). In Juarez, women receiving interactive vs. didactic injection risk interventions decreased receptive needle-sharing by 85% vs. 71%, respectively (p = 0.04); in Tijuana, receptive needle sharing declined by 95%, but was similar in active versus didactic groups. Tijuana women reported significant increases in access to syringes and condoms, but Juarez women did not. Interpretation After 12 months in both cities, the interactive sexual risk intervention significantly reduced HIV/STI incidence. Expanding free access to sterile syringes coupled with brief, didactic education on safer injection was necessary and sufficient for achieving robust, sustained

  11. Hydrologic evaluation of salinity control and reclamation projects in the Indus Plain, Pakistan--A summary

    USGS Publications Warehouse

    Mundorff, Maurice John; Carrigan, P.H.; Steele, T.D.; Randall, A.D.

    1976-01-01

    This report summarizes the observations and findings of a team of four specialists from the U.S. Geological Survey assigned to Pakistan under the auspices of the U.S. Agency for International Development during May to August 1972 for a hydrologic evaluation of Salinity Control and Reclamation Projects in the Indus Plain Individual members of the team undertook comprehensive studies related to climatology, surface-water hydrology, and the canal system; streamflow and sediment yields of the rivers; computer applications to hydrologic data; aquifer characteristics; hydrologic evaluation of Salinity Control and Reclamation Projects (SCARPs); tubewell performance; hydrology of shallow versus deep tubewells; well and well-screen design in the Indus Plain; evaluation of observed and anticipated trends in both private and public tubewell development; evaluation of water-quality programs, data analysis, and records, and computer coding of special water-quality data; and evaluation of water-level data, well discharge and specific-capacity tests and aquifer tests. The reclamation program, by pumping from tubewells, has been notably successful in lowering the water table, in providing supplemental water for irrigation and for leaching of salinized soils, and in improving crop production. Some changes in water quality have been observed in SCARP-I and the Mona Scheme of SCARP-II, but these have not as yet (1972) significantly affected the utility of the water for irrigation. Problems associated with reclamation include control of deterioration in performance of tubewells and their rehabilitation, local brackish or saline-water encroachment, and maintenance of a favorable salt balance in the ground-water system. Rapid and as yet (1972) unregulated growth of shallow private tubewell development in the past decade has introduced complicating factors to the reclamation planning of the early 1960's which had emphasized public tubewell development through the SCARP program. In

  12. International Nosocomial Infection Control Consortium (INICC) report, data summary of 36 countries, for 2004-2009.

    PubMed

    Rosenthal, Victor D; Bijie, Hu; Maki, Dennis G; Mehta, Yatin; Apisarnthanarak, Anucha; Medeiros, Eduardo A; Leblebicioglu, Hakan; Fisher, Dale; Álvarez-Moreno, Carlos; Khader, Ilham Abu; Del Rocío González Martínez, Marisela; Cuellar, Luis E; Navoa-Ng, Josephine Anne; Abouqal, Rédouane; Guanche Garcell, Humberto; Mitrev, Zan; Pirez García, María Catalina; Hamdi, Asma; Dueñas, Lourdes; Cancel, Elsie; Gurskis, Vaidotas; Rasslan, Ossama; Ahmed, Altaf; Kanj, Souha S; Ugalde, Olber Chavarría; Mapp, Trudell; Raka, Lul; Yuet Meng, Cheong; Thu, Le Thi Anh; Ghazal, Sameeh; Gikas, Achilleas; Narváez, Leonardo Pazmiño; Mejía, Nepomuceno; Hadjieva, Nassya; Gamar Elanbya, May Osman; Guzmán Siritt, María Eugenia; Jayatilleke, Kushlani

    2012-06-01

    The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia).

  13. Effects of intracutaneous injections of sterile water in patients with acute low back pain: a randomized, controlled, clinical trial

    PubMed Central

    Cui, J.Z.; Geng, Z.S.; Zhang, Y.H.; Feng, J.Y.; Zhu, P.; Zhang, X.B.

    2016-01-01

    Intracutaneous sterile water injection (ISWI) is used for relief of low back pain during labor, acute attacks of urolithiasis, chronic neck and shoulder pain following whiplash injuries, and chronic myofascial pain syndrome. We conducted a randomized, double-blinded, placebo-controlled trial to evaluate the effect of ISWI for relief of acute low back pain (aLBP). A total of 68 patients (41 females and 27 males) between 18 and 55 years old experiencing aLBP with moderate to severe pain (scores ≥5 on an 11-point visual analogue scale [VAS]) were recruited and randomly assigned to receive either ISWIs (n=34) or intracutaneous isotonic saline injections (placebo treatment; n=34). The primary outcome was improvement in pain intensity using the VAS at 10, 45, and 90 min and 1 day after treatment. The secondary outcome was functional improvement, which was assessed using the Patient-Specific Functional Scale (PSFS) 1 day after treatment. The mean VAS score was significantly lower in the ISWI group than in the control group at 10, 45, and 90 min, and 1 day after injection (P<0.05, t-test). The mean increment in PSFS score of the ISWI group was 2.9±2.2 1 day after treatment, while that in the control group was 0.9±2.2. Our study showed that ISWI was effective for relieving pain and improving function in aLBP patients at short-term follow-up. ISWI might be an alternative treatment for aLBP patients, especially in areas where medications are not available, as well as in specific patients (e.g., those who are pregnant or have asthma), who are unable to receive medications or other forms of analgesia because of side effects. PMID:26840703

  14. Summary of property damage control programs of the United States Department of Energy CY 1979

    SciTech Connect

    Dix, George P.; Maybee, Walter W.

    1980-10-01

    Calendar year 1979 was the second full year of operation of the Department of Energy. This report summarizes the loss experience in overall terms and itemizes facility and program achievements in property protection. Planned projects for CY 1980 are included and several subjects of interest to loss-control specialists are discussed in detail. Property damage from all causes was $2.5 million, of which $0.65 million was due to fire, the major cause of losses in both the Department of Energy and its predecessor agencies. Combined losses for the 2 full years of Department of Energy experience total over $20 million, of which over $13 million is due to fire. The fire loss ratio for 1979 was 0.13 cents for each $100 of property values at risk, more than an order-of-magnitude less than that expeienced by the better class of insured private property. Final decontamination and cleanup costs necessitated by a product spill at a solvent-refined coal pilot plant at the end of 1979 may exceed $2 million. Even including this estimate, the total loss from all causes (fire, explosion, mechanical or electrical damage, acts of nature, radioactive and non-radioactive contamination/cleanup costs, and a variety of miscellaneous causes), would yield a loss ratio of about 1 cent for each $100 of property. This indicated the overall property protection program is exemplary.

  15. Tug fleet and ground operations schedules and controls. Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    1975-01-01

    This study presents Tug Fleet and Ground Operations Schedules and Controls plan. This plan was developed and optimized out of a combination of individual Tug program phased subplans, special emphasis studies, contingency analyses and sensitivity analyses. The subplans cover the Tug program phases: (1) Tug operational, (2) Interim Upper Stage (IUS)/Tug fleet utilization, (3) and IUS/Tug payload integration, (4) Tug site activation, (5) IUS/Tug transition, (6) Tug acquisition. Resource requirements (facility, GSE, TSE, software, manpower, logistics) are provided in each subplan, as are appropriate Tug processing flows, active and total IUS and Tug fleet requirements, fleet management and Tug payload integration concepts, facility selection recommendations, site activation and IUS to Tug transition requirements. The impact of operational concepts on Tug acquisition is assessed and the impact of operating Tugs out of KSC and WTR is analyzed and presented showing WTR as a delta. Finally, cost estimates for fleet management and ground operations of the DDT&E and operational phases of the Tug program are given.

  16. [Descriptive summary of the classical swine fever control in wild boar in Germany since 2005].

    PubMed

    Staubach, Christoph; Höreth-Böntgen, Detlef; Blome, Sandra; Fröhlich, Andreas; Blicke, Julia; Jahn, Birgit; Teuffert, Jürgen; Kramers, Matthias

    2013-01-01

    Classical swine fever (CSF) in wild boar repeatedly appeared in different federal states of the Federal Republic of Germany since 1995, from which it has been successfully eradicated sometimes fast, sometimes in a more time taking way using oral immunization as a main element of control. Since 2005 the cases focused solely on North Rhine-Westphalia and Rhineland-Palatinate. In the present study, therefore, the situation of CSF in wild boar has been closely investigated concerning the period 2005 to 2012 in these two regions. It is noteworthy that in this period two different variants of the virus subtype 2.3 occurred in two regionally defined areas of the "Eifel" and "Westerwald" as well as in the "Pfalz". The two Federal States have undertaken extensive oral vaccination campaigns and surveillance activities, which enabled an assessment of the existing virus prevalence and serological prevalence in the different regions. After an initial high serological prevalence, caused probably by interaction of infection and vaccination, the serological levels stabilized seasonally adjusted in a range from 50 to 60% in almost all areas. The vaccination campaigns have been maintained by both Federal States over a period of at least 2.5 years after virus has been detected for the last time. In consequence Germany as a whole has been recognized for the first time to be officially free from CSF in wild boar. By genotyping of virus isolates it has been demonstrated that the virus changed over time and played a role in the outbreak area "Westerwald".

  17. Summary of longitudinal stability and control parameters as determined from Space Shuttle Challenger flight test data

    NASA Technical Reports Server (NTRS)

    Suit, William T.

    1989-01-01

    Estimates of longitudinal stability and control parameters for the space shuttle were determined by applying a maximum likelihood parameter estimation technique to Challenger flight test data. The parameters for pitching moment coefficient, C(m sub alpha), (at different angles of attack), pitching moment coefficient, C(m sub delta e), (at different elevator deflections) and the normal force coefficient, C(z sub alpha), (at different angles of attack) describe 90 percent of the response to longitudinal inputs during Space Shuttle Challenger flights with C(m sub delta e) being the dominant parameter. The values of C(z sub alpha) were found to be input dependent for these tests. However, when C(z sub alpha) was set at preflight predictions, the values determined for C(m sub delta e) changed less than 10 percent from the values obtained when C(z sub alpha) was estimated as well. The preflight predictions for C(z sub alpha) and C(m sub alpha) are acceptable values, while the values of C(z sub delta e) should be about 30 percent less negative than the preflight predictions near Mach 1, and 10 percent less negative, otherwise.

  18. Modeling sorbent injection for mercury control in baghouse filters: I--model development and sensitivity analysis.

    PubMed

    Flora, Joseph R V; Hargis, Richard A; O'Dowd, William J; Pennline, Henry W; Vidic, Radisav D

    2003-04-01

    A two-stage mathematical model for Hg removal using powdered activated carbon injection upstream of a baghouse filter was developed, with the first stage accounting for removal in the ductwork and the second stage accounting for additional removal caused by the retention of carbon particles on the filter. The model shows that removal in the ductwork is minimal, and the additional carbon detention time from the entrapment of the carbon particles in the fabric filter enhances the Hg removal from the gas phase. A sensitivity analysis on the model shows that Hg removal is dependent on the isotherm parameters, the carbon pore radius and tortuosity, the C/Hg ratio, and the carbon particle radius.

  19. Phonon-assisted coherent control of injected carriers in indirect bandgap semiconductors

    NASA Astrophysics Data System (ADS)

    Rioux, Julien; Nastos, Fred; Sipe, John E.

    2007-03-01

    Charge and spin currents can be generated in direct semiconductors by quantum interference between one- and two-photon absorption. For semiconductors such as Si and Ge, optical injection of carriers over the indirect bandgap must be assisted by momentum transfer from phonon scattering. We consider the optical properties for such 1+2 photon processes in the presence of the electron-phonon interaction. The latter is modelled by acoustic deformation potential. Indirect transitions involve double Brillouin zone integrations, which are computed by a linearized tetrahedron method. We compare our results to those for bulk GaAs. M.J. Stevens, R.D.R. Bhat, A. Najmaie, H.M. van Driel, J.E. Sipe and A.L. Smirl, in Optics of Semiconductors and Their Nanostructures, edited by H. Kalt and M. Hetterich (Springer, Berlin, 2004), vol. 146 of Springer Series in Solid-State Sciences, p. 209.

  20. The use of wetlands and chemical injections to control sediment and soluble phosphorus

    NASA Astrophysics Data System (ADS)

    Ippolito, Jim; Bjorneberg, Dave

    2015-04-01

    Irrigated agriculture accounts for ~25% of the total US cropland, yet comprises 55% of the US crop value. These systems play a major role in US production agriculture, and thus it is important to manage irrigated systems to maintain or improve environmental quality. Irrigated agriculture in the western has historically utilized furrow irrigation. It has long been recognized that furrow irrigation causes particle detachment and transport, leading to increased sediment and nutrient (e.g. P) loads to receiving water bodies. The use of engineered wetlands in furrow irrigation settings can help capture sediment and sediment-bound P (>90-95%). One of the main water quality challenges that exists today is reducing soluble P in irrigation waters returning to receiving water bodies. This presentation will focus on the use of strategically located wetlands in conjunction with chemical injections (alum or polyaluminum chloride) to reduce water soluble P in order to meet total maximum daily P loads in receiving water bodies.

  1. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.

    2011-01-01

    This article presents summaries of three articles relevant to school crisis response: (1) "Factors Contributing to Posttraumatic Growth," summarized by Steve DeBlois; (2) "Psychological Debriefing in Cross-Cultural Contexts" (Stacey Rice); and (3) "Brain Abnormalities in PTSD" (Sunny Windingstad). The first summary reports the findings of a…

  2. DOE/NETL's phase II mercury control technology field testing program: preliminary economic analysis of activated carbon injection.

    PubMed

    Jones, Andrew P; Hoffmann, Jeffrey W; Smith, Dennis N; Feeley, Thomas J; Murphy, James T

    2007-02-15

    Based on results of field testing conducted by the U.S. Department of Energy's National Energy Technology Laboratory (DOE/NETL), this article provides preliminary costs for mercury control via conventional activated carbon injection (ACI), brominated ACI, and conventional ACI coupled with the application of a sorbent enhancement additive (SEA) to coal prior to combustion. The economic analyses are reported on a plant-specific basis in terms of the cost required to achieve low (50%), mid (70%), and high (90%) levels of mercury removal "above and beyond" the baseline mercury removal achieved by existing emission control equipment. In other words, the levels of mercury control are directly attributable to ACI. Mercury control costs via ACI have been amortized on a current dollar basis. Using a 20-year book life, levelized costs for the incremental increase in cost of electricity (COE), expressed in mills per kilowatt-hour (mills/kWh), and the incremental cost of mercury control, expressed in dollars per pound of mercury removed ($/lb Hg removed), have been calculated for each level of ACI mercury control. For this analysis, the increase in COE varied from 0.14 mills/kWh to 3.92 mills/kWh. Meanwhile, the incremental cost of mercury control ranged from $3810/lb Hg removed to $166000/lb Hg removed.

  3. Comparison of injection pain, heart rate increase, and postinjection pain of articaine and lidocaine in a primary intraligamentary injection administered with a computer-controlled local anesthetic delivery system.

    PubMed Central

    Nusstein, John; Berlin, Jeffrey; Reader, Al; Beck, Mike; Weaver, Joel M.

    2004-01-01

    The purpose of this prospective, randomized, double-blind study was to compare the pain of injection, heart rate increase, and postinjection pain of the intraligamentary injection of 4% articaine with 1:100,000 epinephrine and 2% lidocaine with 1:100,000 epinephrine administered with a computer-controlled local anesthetic delivery system. Using a crossover design, intraligamentary injections of 1.4 mL of 4% articaine with 1:100,000 epinephrine and 1.4 mL of 2% lidocaine with 1:100,000 epinephrine were randomly administered on the mesial and distal aspects of the mandibular first molar with a computer-controlled local anesthetic delivery system in a double-blind manner at 2 separate appointments to 51 subjects. The results demonstrated the incidence of moderate pain was 14%-27% with needle insertion, with 0%-4% reporting severe pain. For solution deposition, moderate pain was reported 8%-18% of the time, with no reports of severe pain. There were no significant differences between the articaine and lidocaine solutions. Regarding heart rate changes, neither anesthetic solution resulted in a significant increase in heart rate over baseline readings. On day 1 postinjection, there was a 31% incidence of moderate/severe pain with the articaine solution and 20% incidence of moderate/severe pain with the lidocaine solution. The moderate/severe pain ratings decreased over the next 2 days. There were no significant differences between the articaine and lidocaine solutions. We concluded that the intraligamentary injection of 4% articaine with 1:100,000 epinephrine was similar to 2% lidocaine with 1:100,000 epinephrine for injection pain and postinjection pain in the mandibular first molar when administered with a computer-controlled local anesthetic delivery system. For both anesthetic solutions, heart rate did not significantly increase with the intraligamentary injection using the computer-controlled local anesthetic system. PMID:15675261

  4. Stability of butorphanol-tropisetron mixtures in 0.9% sodium chloride injection for patient-controlled analgesia use.

    PubMed

    Chen, Fu-Chao; Shi, Xiao-Ya; Li, Peng; Yang, Jin-Guo; Zhou, Ben-Hong

    2015-02-01

    Tropisetron is an adjuvant for butorphanol used in intravenous patient-controlled analgesia (PCA) and has been reported to provide superior pain control. It is efficacious in reducing the incidence of postoperative nausea and vomiting. However, this admixture is not available commercially and stability data applicable to hospital practice are limited. This study aimed to describe the drug compounding and evaluates the long-term (up to 14 days) stability of butorphanol and tropisetron in 0.9% sodium chloride injection for PCA use.In this study, commercial solutions of butorphanol tartrate and tropisetron hydrochloride were combined and further diluted with 0.9% sodium chloride injection to final concentrations of butorphanol tartrate 0.08 mg/mL and tropisetron hydrochloride 0.05 mg/mL. The polyolefin bags and glass bottles were stored at 4°C and 25°C for up to 14 days. The drug stabilities were determined by visual inspection, pH measurement, and high-pressure liquid chromatography assay of drug concentrations.The data obtained for admixtures prepared and stored at temperatures of 25°C and 4°C show the drugs have maintained at least 98% of the initial concentration. All solutions remained clear and colorless over the 14-day period, and the pH value did not change significantly.The results indicate that admixtures of butorphanol tartrate 0.08 mg/mL and tropisetron hydrochloride 0.05 mg/mL in 0.9% sodium chloride injection solution were stable for 14 days when stored in polyolefin bags or glass bottles at 4°C and 25°C and protected from light. The infusion is feasible for manufacturing in pharmacy aseptic units and can be stored for up to 14 days for routine use in PCA infusions.

  5. Cabazitaxel Injection

    MedlinePlus

    ... injection is used along with prednisone to treat prostate cancer (cancer of a male reproductive organ) that has ... cabazitaxel injection is usually used in men with prostate cancer. If used by pregnant women, cabazitaxel injection can ...

  6. Fondaparinux Injection

    MedlinePlus

    ... fondaparinux injection.Talk to your doctor about the risk of using fondaparinux injection. ... Fondaparinux injection is used to prevent deep vein thrombosis (DVT; a blood ... Xa inhibitors. It works by decreasing the clotting ability of the blood.

  7. Morphine Injection

    MedlinePlus

    Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate ( ... Morphine injection comes as a solution (liquid) to inject intramuscularly (into a muscle) or intravenously (into a ...

  8. Dexamethasone Injection

    MedlinePlus

    Dexamethasone injection is used to treat severe allergic reactions. It is used in the management of certain types of ... gastrointestinal disease, and certain types of arthritis. Dexamethasone injection is also used for diagnostic testing. Dexamethasone injection ...

  9. Romidepsin Injection

    MedlinePlus

    Romidepsin injection is used to treat cutaneous T-cell lymphoma (CTCL; a group of cancers of the immune system ... one other medication given by mouth or by injection. Romidepsin injection is in a class of medications ...

  10. Ondansetron Injection

    MedlinePlus

    Zofran® Injection ... Ondansetron injection is used to prevent nausea and vomiting caused by cancer chemotherapy and surgery. Ondansetron is in a ... medications: or any of the ingredients in ondansetron injection. Ask your pharmacist for a list of the ...

  11. Nonlinear Burn Control in Tokamaks using Heating, Non-axisymmetric Magnetic Fields, Isotopic fueling and Impurity injection

    NASA Astrophysics Data System (ADS)

    Pajares, Andres; Schuster, Eugenio

    2016-10-01

    Plasma density and temperature regulation in future tokamaks such as ITER is arising as one of the main problems in nuclear-fusion control research. The problem, known as burn control, is to regulate the amount of fusion power produced by the burning plasma while avoiding thermal instabilities. Prior work in the area of burn control considered different actuators, such as modulation of the auxiliary power, modulation of the fueling rate, and controlled impurity injection. More recently, the in-vessel coil system was suggested as a feasible actuator since it has the capability of modifying the plasma confinement by generating non-axisymmetric magnetic fields. In this work, a comprehensive, model-based, nonlinear burn control strategy is proposed to integrate all the previously mentioned actuators. A model to take into account the influence of the in-vessel coils on the plasma confinement is proposed based on the plasma collisionality and the density. A simulation study is carried out to show the capability of the controller to drive the system between different operating points while rejecting perturbations. Supported by the US DOE under DE-SC0010661.

  12. Controlled surface oxidation of multi-layered graphene anode to increase hole injection efficiency in organic electronic devices

    NASA Astrophysics Data System (ADS)

    Han, Tae-Hee; Kwon, Sung-Joo; Seo, Hong-Kyu; Lee, Tae-Woo

    2016-03-01

    Ultraviolet ozone (UVO) surface treatment of graphene changes its sp2-hybridized carbons to sp3-bonded carbons, and introduces oxygen-containing components. Oxidized graphene has a finite energy band gap, so UVO modification of the surface of a four-layered graphene anode increases its surface ionization potential up to ∼5.2 eV and improves the hole injection efficiency (η) in organic electronic devices by reducing the energy barrier between the graphene anode and overlying organic layers. By controlling the conditions of the UVO treatment, the electrical properties of the graphene can be tuned to improve η. This controlled surface modification of the graphene will provide a way to achieve efficient and stable flexible displays and solid-state lighting.

  13. Controlling the injection of ammonia in a dry type exhaust gas denitration process

    SciTech Connect

    Shiraishi, Y.; Ukawa, N.

    1982-02-02

    In a first processor unit the relationship between the amount of nitrogen oxides in a combustion exhaust gas and a numerical value representing an amount of combustion, E.G. - fuel flow rate or the like, is stored. In a second processor unit the ratio of ammonia to nitrogen oxides as a function of the combustion exhaust gas temperature is stored. A numerical value corresponding to the actual measured amount of combustion is inputted to the first processor unit to derive the amount of nitrogen oxides in the combustion exhaust gas. The actual measured combustion exhaust gas temperature is inputted to the second processor unit to derive the ratio of ammonia to nitrogen oxides. The optimum amount of ammonia to be injected is derived by multiplying the amount of nitrogen oxides, derived by means of the first processor unit, by the ratio of ammonia to nitrogen oxides derived by means of the second processor unit. In a preferable embodiment of the present invention, the ratio of ammonia to nitrogen oxides is corrected before the multiplication by means of a correction factor which is stored in a third processor unit and which corresponds to a time variation rate of the combustion exhaust gas temperature.

  14. Controlled delivery of platelet-derived growth factor-BB from injectable microsphere/hydrogel composites.

    PubMed

    Wu, Hua; Liu, Jiaoyan; Wu, Jingjing; Wan, Ying; Chen, Yun

    2016-12-01

    Platelet-derived growth factor-BB (PGDF-BB) loaded gelatin microspheres with an average size of about 2μm was incorporated into chitosan/silk fibroin/glycerophosphate (GP) solutions to prepare composites. The formulated composite solutions were able to form into hydrogels in a temperature range between 32 and 37°C at a pH of ca.7. They had good fluidity at 25°C and showed shear-thinning features at both 25 and 37°C, revealing that they are injectable at room temperature. Elastic modulus of some composites at 37°C was about 10-fold higher than that of chitosan/GP gel, confirming that these composites behave like mechanically strong gels. Optimal composites showed abilities to administrate PDGF-BB release in an approximately linear manner up to 5 weeks. The PDGF-BB release could be regulated by the PDGF-BB load and the silk fibroin content in the composites in an individual or cooperative way. In vivo degradation of composites demonstrated that some of them had markedly enhanced degradation endurance as compared to the chitosan/GP gel. PDGF-BB-stimulated DNA synthesis in Balb/c 3T3 fibroblasts and PDGF-BB-induced cell migration suggested that the bioactivity of released PDGF-BB was well retained.

  15. Long-Acting Injectable Antipsychotics for Prevention of Relapse in Bipolar Disorder: A Systematic Review and Meta-Analyses of Randomized Controlled Trials

    PubMed Central

    Oya, Kazuto; Iwata, Nakao

    2016-01-01

    Background: This meta-analysis of randomized controlled trials aimed to examine the advantages of long-acting injectable antipsychotics over placebo or oral medications regarding efficacy and safety for patients with bipolar disorder. Methods: Two categorical meta-analyses of randomized controlled trials were performed to compare study-defined relapse rate (primary), discontinuation rates, and individual adverse events: (1) risperidone-long-acting injectable vs placebo, and (2) long-acting injectable antipsychotics vs oral medications. Results: We identified 7 randomized controlled trials (n=1016; long-acting injectable antipsychotics [flupenthixol (1 randomized controlled trial) and risperidone (6 randomized controlled trials)=449]; oral medications [mood stabilizers, antidepressants, antipsychotic, or any combination of these agents=283]; and placebo=284). Risperidone-long-acting injectable antipsychotic was superior to placebo for study-defined relapse rate (risk ratio=0.63, P<.0001), relapse of manic symptoms (risk ratio=0.42, P<.00001), and all-cause discontinuation (risk ratio=0.75, P=.007). Risperidone-long-acting injectable was associated with higher incidence of prolactin-related adverse events (risk ratio=4.82, P=.001) and weight gain (risk ratio=3.80, P<.0001) than placebo. The pooled long-acting injectable antipsychotics did not outperform oral medications regarding primary outcome but with significant heterogeneity (I2=74%). Sensitivity analysis, including only studies with rapid cycling or high frequency of relapse patients, revealed that long-acting injectable antipsychotics were superior compared to oral medications (I2=0%, RR=0.58, P=.0004). However, the comparators in this sensitivity analysis did not include second-generation antipsychotic monotherapy. In sensitivity analysis, including only studies with second-generation antipsychotic monotherapy as the comparator, long-acting injectable antipsychotics did not outperform second

  16. Precise and high-speed control of partial pressures of multiple gas species in plasma process chamber using pulse-controlled gas injection

    SciTech Connect

    Morishita, Sadaharu; Goto, Tetsuya; Nagase, Masaaki; Ohmi, Tadahiro

    2009-05-15

    Multiprocesses in a single plasma process chamber with high throughput require precise, sequential, high-speed alteration of partial pressures of multiple gas species. A conventional gas-distribution system cannot realize this because the system seriously overshoots gas pressure immediately following valve operation. Furthermore, chamber volume and conductance of gas piping between the system and chamber should both be considered because they delay the stabilizing time of gas pressure. Therefore, the authors proposed a new gas-distribution system without overshoot by controlling gas flow rate based on pressure measurement, as well as a method of pulse-controlled gas injection immediately following valve operation. Time variation of measured partial pressure agrees well with a calculation based on an equivalent-circuit model that represents the chamber and gas piping between the system and chamber. Using pulse-controlled gas injection, the stabilizing time can be reduced drastically to 0.6 s for HBr added to pure Ar plasma, and 0.7 s for O{sub 2} added to Ar/HBr plasma; without the pulse control, the stabilizing times are 3 and 7 s, respectively. In the O{sub 2} addition case, rapid stabilization can be achieved during the period of line/space pattern etching of poly-Si on a thin SiO{sub 2} film. This occurs without anomalous etching of the underlying SiO{sub 2} film or the Si substrate near the sidewall, thus obtaining a wide process margin with high throughput.

  17. Effectiveness of splinting and splinting plus local steroid injection in severe carpal tunnel syndrome: A Randomized control clinical trial

    PubMed Central

    Khosrawi, Saeid; Emadi, Masoud; Mahmoodian, Amir Ebrahim

    2016-01-01

    Background: The Study aimed to compare the effectiveness of two commonly used conservative treatments, splinting and local steroid injection in improving clinical and nerve conduction findings of the patients with severe carpal tunnel syndrome (CTS). Materials and Methods: In this randomized control clinical trial, the patients with severe CTS selected and randomized in two interventional groups. Group A was prescribed to use full time neutral wrist splint and group B was injected with 40 mg Depo-Medrol and prescribed to use the full time neutral wrist splint for 12 weeks. Clinical and nerve conduction findings of the patients was evaluated at baseline, 4 and 12 weeks after interventions. Results: Twenty-two and 21 patients were allocated in group A and B, respectively. Mean of clinical symptoms and functional status scores, nerve conduction variables and patients’ satisfaction score were not significant between group at baseline and 4 and 12 weeks after intervention. Within the group comparison, there was significant improvement in the patients’ satisfaction, clinical and nerve conduction items between the baseline level and 4 weeks after intervention and between the baseline and 12 weeks after intervention (P < 0.01). The difference was significant for functional status score between 4 and 12 weeks after intervention in group B (P = 0.02). Conclusion: considering some findings regarding the superior effect of splinting plus local steroid injection on functional status scale and median nerve distal motor latency, it seems that using combination therapy could be more effective for long-term period specially in the field of functional improvement of CTS. PMID:26962518

  18. Diesel fuel injection pump with electronically controlled fuel spilling and cutoff and recirculation venting of split fuel

    SciTech Connect

    Kobayashi, F.; Ito, Y.

    1986-01-14

    This patent describes a fuel injection pump for a diesel engine. The pump consists of a number of intercommunicating parts. The first part is a housing containing a bore. Analogously, the patent describes a plunger slidably fitted in the bore for reciprocation with respect to housing in response to engine rotation, the bore defining a high pressure chamber at one end of the plunger. A first electromagnetic valve for shutting off fuel to the pump when the engine is not running, is also described and characterized as having an inlet adapted to be connected to a source of fuel at a relatively low pressure and an outlet. Connected to the outlet of the first electromagnetic valve is the upstream end of a fuel supply passage. The downstream end of the fuel supply leads to the high pressure chamber. A means for communicating the high pressure chamber with a fuel injection line substantially only when the plunger is moving in a second direction to reduce the size of the high pressure chamber is represented. Similarly, a means for selectively communicating the high pressure chamber with a vent passage in order to control the amount of fuel delivered during each fuel injection is described and is characterized as a principal feature of this patent. This selective modality of communication consists of two components. The first component is a second electromagnetic valve having an inlet connected to the high pressure chamber and an outlet connected to the fuel supply passage. The second component is a means for selectively opening the second electromagnetic valve to communicate the high pressure chamber with the fuel supply passage for a predetermined minimum time in response to the closing of the first electromagnetic valve.

  19. State and national energy environmental risk analysis systems for underground injection control. Final report, April 7, 1992--May 31, 1995

    SciTech Connect

    1995-05-01

    The purpose of this effort is to develop and demonstrate the concept of a national Energy and Environmental Risk Analysis System that could support DOE policy analysis and decision-making. That effort also includes the development and demonstration of a methodology for assessing the risks of groundwater contamination from underground injection operations. EERAS is designed to enhance DOE`s analytical capabilities by working with DOE`s existing resource analysis models for oil and gas. The full development of EERAS was not planned as part of this effort. The design and structure for the system were developed, along with interfaces that facilitate data input to DOE`s other analytical tools. The development of the database for EERAS was demonstrated with the input of data related to underground injection control, which also supported the risk assessment being performed. The utility of EERAS has been demonstrated by this effort and its continued development is recommended. Since the absolute risk of groundwater contamination due to underground injection is quite low, the risk assessment methodology focuses on the relative risk of groundwater contamination. The purpose of this methodology is to provide DOE with an enhanced understanding of the relative risks posed nationwide as input to DOE decision-making and resource allocation. Given data problems encountered, a broad assessment of all oil reservoirs in DOE`s resource database was not possible. The methodology was demonstrated using a sample of 39 reservoirs in 15 states. While data difficulties introduce substantial uncertainties, the results found are consistent with expectations and with prior analyses. Therefore the methodology for performing assessments appears to be sound. Recommendations on steps that can be taken to resolve uncertainties or obtain improved data are included in the report.

  20. Neutral beam injection system

    SciTech Connect

    Duesing, G.; Altmann, H.; Falter, H.; Goede, A.; Haange, R.; Hemsworth, R.S.; Kupschus, P.; Stork, D.; Thompson, E.

    1987-01-01

    The development of the neutral injection (NI) system for the Joint European Torus and its status in 1985 are reported. First the system parameters are discussed and the layout is described, followed by a summary of the physics design calculations, the development, production, and testing of the components and the subsystem assembly. The system commissioning is presented, including a description of the function and the realization of the NI test bed. A summary of performance predictions for 80-keV beam heating experiments, and of the experimental evidence on balanced versus coinjection, is presented. The operational experience with the first injector and the plasma physics results obtained so far are summarized.

  1. Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway.

    PubMed Central

    Braddock, M; Muckenthaler, M; White, M R; Thorburn, A M; Sommerville, J; Kingsman, A J; Kingsman, S M

    1994-01-01

    The translation of a capped, polyadenylated RNA after injection into the nucleus of Xenopus oocytes occurs only if the RNA contains an intron. A single point mutation in the splice donor site prevents translation. Intron-less RNA is exported efficiently to the cytoplasm and is held, undegraded, in a translationally inert state for several days. Translation can be activated by treating the oocytes with progesterone or by injecting antibodies that bind the FRGY2 class of messenger RNA binding proteins, p56 and p60, but these antibodies are only effective if delivered to the nucleus. Inhibitors of casein kinase II also activate translation whereas phosphatase inhibitors block progesterone-mediated activation of translation. These data suggest the presence of an RNA handling pathway in the nucleus of Xenopus oocytes which is regulated by casein kinase type II phosphorylation and which directs transcripts to be sequestered by p56/p60 or by closely related proteins. This pathway can be bypassed if the RNA contains an intron and it can be reversed by progesterone treatment. These data may have implications for understanding translational control during early development. Images PMID:7816614

  2. Investigation of SF6 injection during cyclic C2H2/SF6 flow for the formation of geometrically controlled carbon coils.

    PubMed

    Jeon, Young-Chul; Park, Bitna; Park, Semi; Kim, Sung-Hoon

    2014-12-01

    Carbon coils could be synthesized using C2H2/H2 as source gases along with SF6 as an incorporated additive gas using a thermal chemical vapor deposition (CVD) system. To obtain geometrically controlled carbon coils, a cyclic process, namely the turning on and off of C2H2 or SF6 flow during the initial reaction stage, was carried out. According to the different reaction processes, different interruption/injection times of C2H2 or SF6 flow and different injection sequences of the gas flow were investigated while maintaining the identical overall injection time of C2H2 and/or SF6 flow. The formation of carbon microcoils (CMCs) is favored by the lowest interruption/injection time ratio of SF6 flow within one cycle. In addition, the injection of SF6 flow prior to the injection of C2H2 flow promotes the formation of CMCs. Based on these results we revealed the role of the SF6 flow injection for the enhanced formation of geometrically controlled CMCs. The etching of materials, thereby promoting an increase in the number of nucleation sites for the survived growth species to form CMCs, by the increased fluorine concentration, originating from the dominant SF6 influx, is understood to be the main cause for the exclusive CMCs formation.

  3. EMISSION TEST REPORT, OMSS FIELD TEST ON CARBON INJECTION FOR MERCURY CONTROL

    EPA Science Inventory

    The report discusses results of a parametric evaluation of powdered activated carbon for control of mercury (Hg) emission from a municipal waste cornbustor (MWC) equipped with a lime spray dryer absorber/fabric filter (SD/FF). The primary test objectives were to evaluate the effe...

  4. Ibandronate Injection

    MedlinePlus

    Boniva® Injection ... Ibandronate injection is used to treat osteoporosis (a condition in which the bones become thin and weak and break ... Ibandronate injection comes as a solution (liquid) to be injected into a vein by a doctor or nurse in ...

  5. Leuprolide Injection

    MedlinePlus

    Leuprolide injection comes as a long-acting suspension (Lupron) that is injected intramuscularly (into a muscle) by a doctor or nurse in a medical ... Depot-4 month, Lupron Depot-6 Month). Leuprolide injection also comes as a long-acting suspension (Eligard) that is injected subcutaneously (just under ...

  6. Injectable Sources of Locally Controlled Electrical Fields to Facilitate Tissue Repair

    DTIC Science & Technology

    2007-11-02

    controlling the developmental growth deformities found in cleft lip & palate and craniofacial anomalies [2]. The requisite ’wiring’ of the wounds presents...representation of "Developmental Osteogenic Stimulation" [2] being used to direct and promote maxillary and palatal shelf growth following cleft lip ... palate repair. 4 each require a 0.8 V polarization. • The compliance voltage needed to generate the required current will thus be 0.8 + 0.8 + 0.4

  7. Alkali injection system with controlled CO.sub.2 /O.sub.2 ratios for combustion of coal

    DOEpatents

    Berry, Gregory F.

    1988-01-01

    A high temperature combustion process for an organic fuel containing sulfur n which the nitrogen of air is replaced by carbon dioxide for combination with oxygen with the ratio of CO.sub.2 /O.sub.2 being controlled to generate combustion temperatures above 2000 K. for a gas-gas reaction with SO.sub.2 and an alkali metal compound to produce a sulfate and in which a portion of the carbon-dioxide rich gas is recycled for mixing with oxygen and/or for injection as a cooling gas upstream from heating exchangers to limit fouling of the exchangers, with the remaining carbon-dioxide rich gas being available as a source of CO.sub.2 for oil recovery and other purposes.

  8. Target Diffusion and Concentration Control of Varying Hydrophobicity Drugs in an Injectable Solid Self-Assembling Peptide Hydrogel

    NASA Astrophysics Data System (ADS)

    Sun, Jessie E. P.; Langhans, Sigrid; Lee, Seung Joon; Sathaye, Sameer; Schneider, Joel P.; Pochan, Darrin J.

    2013-03-01

    We studied diffusion profiles of varying hydrophobicity drugs in a beta-hairpin peptide hydrogel solid that is shear thinning, injectable, and immediate reheals after shear. These rheological properties result from its entangled and branched fibrillar nanostructures, formed from intrmolecular folding and consequent intermolecular assembly of the peptides. Different chemotherapeutic drugs at different concentrations with greatly differing properties were encapsulated to show direct targeting drug delivery. Using in vitro and spectroscopy techniques, we showed controlled, sustained diffusion of the drugs. We were able to protect and keep active, hydrophobic agents that otherwise would be deactivated through traditional delivery methods. We also showed that we can maintain low, targeted, and constant dosages, preserving surrounding areas from lack of target specificity of certain drugs.

  9. Optoelectronic imaging using a millimeter-wave, optically controlled, photo-injected Fresnel-zone plate antenna

    NASA Astrophysics Data System (ADS)

    Gallacher, Tom F.; Robertson, Duncan A.; Smith, Graham M.

    2012-11-01

    We present results for a rapid, precise, and wide field-of-view scanning antenna for use at millimeter and submillimeter wavelengths, based on the photo-injected Fresnel-zone plate antenna (piFZPA) method. In this paper, we demonstrate the potential of this technology as a viable solution for a range of applications demanding real-time imagery or high flexibility and beam fidelity at these frequencies. We present proof-of-principle experiments at 94 GHz that incorporate a commercial display technology operating at visible wavelengths. The 100-mm-diameter piFZPA achieves 37-dBi directivity, excellent beam symmetry, beam steering in two dimensions over a ±20-deg field of view, and precise beam control and repeatability. Preliminary results of a piFZPA-based, short-range, 94-GHz, three-dimensional imaging radar are also presented.

  10. Optimising corticosteroid injection for lateral epicondylalgia with the addition of physiotherapy: A protocol for a randomised control trial with placebo comparison

    PubMed Central

    Coombes, Brooke K; Bisset, Leanne; Connelly, Luke B; Brooks, Peter; Vicenzino, Bill

    2009-01-01

    Background Corticosteroid injection and physiotherapy are two commonly prescribed interventions for management of lateral epicondylalgia. Corticosteroid injections are the most clinically efficacious in the short term but are associated with high recurrence rates and delayed recovery, while physiotherapy is similar to injections at 6 weeks but with significantly lower recurrence rates. Whilst practitioners frequently recommend combining physiotherapy and injection to overcome harmful effects and improve outcomes, study of the benefits of this combination of treatments is lacking. Clinicians are also faced with the paradox that the powerful anti-inflammatory corticosteroid injections work well, albeit in the short term, for a non-inflammatory condition like lateral epicondylalgia. Surprisingly, these injections have not been rigorously tested against placebo injections. This study primarily addresses both of these issues. Methods A randomised placebo-controlled clinical trial with a 2 × 2 factorial design will evaluate the clinical efficacy, cost-effectiveness and recurrence rates of adding physiotherapy to an injection. In addition, the clinical efficacy and adverse effects of corticosteroid injection beyond that of a placebo saline injection will be studied. 132 participants with a diagnosis of lateral epicondylalgia will be randomly assigned by concealed allocation to one of four treatment groups – corticosteroid injection, saline injection, corticosteroid injection with physiotherapy or saline injection with physiotherapy. Physiotherapy will comprise 8 sessions of elbow manipulation and exercise over an 8 week period. Blinded follow-up assessments will be conducted at baseline, 4, 8, 12, 26 and 52 weeks after randomisation. The primary outcome will be a participant rating of global improvement, from which measures of success and recurrence will be derived. Analyses will be conducted on an intention-to-treat basis using linear mixed and logistic regression

  11. Assistance to state underground injection control programs and the oil and gas industry with class 2 injection well data management and technology transfer. Final technical report

    SciTech Connect

    Paque, M.J.

    1995-11-23

    The Underground Injection Practices Research Foundation (UIPRF) administered a grant project funded by the US Department of Energy relating to Class 2 injection well operations in various primacy and direct implementation states throughout the country. This effort provided substantial benefits to state regulatory agencies and oil and gas producing companies. It enhanced the protection of the environment through the protection of ground water resources and improved oil and gas production operations within affected states. This project involved the following accomplishment: (1) Completed the design and installation of the only comprehensive, fully relational PC-Based Oil and Gas regulatory data management system (the Risk Based Data Management System) in the country. Additionally, training and data conversion was conduced and the RBDMS User`s Guide and the RBDMS Administrator`s Guide were completed. (2) State wide Area-Of-Review (AOR) workshop were held in California and Oklahoma and a national three-day workshop was held in Kansas City, Missouri where 24 state oil and gas agencies were represented.

  12. Characterization of Reactivity Controlled Compression Ignition (RCCI) Using Premixed Gasoline and Direct-Injected Gasoline with a Cetane Improver on a Multi-Cylinder Engine

    DOE PAGES

    Dempsey, Adam B.; Curran, Scott; Reitz, Rolf D.

    2015-04-14

    The focus of the present paper was to characterize Reactivity Controlled Compression Ignition (RCCI) using a single-fuel approach of gasoline and gasoline mixed with a commercially available cetane improver on a multi-cylinder engine. RCCI was achieved by port-injecting a certification grade 96 research octane gasoline and direct-injecting the same gasoline mixed with various levels of a cetane improver, 2-ethylhexyl nitrate (EHN). The EHN volume percentages investigated in the direct-injected fuel were 10, 5, and 2.5%. The combustion phasing controllability and emissions of the different fueling combinations were characterized at 2300 rpm and 4.2 bar brake mean effective pressure over amore » variety of parametric investigations including direct injection timing, premixed gasoline percentage, and intake temperature. Comparisons were made to gasoline/diesel RCCI operation on the same engine platform at nominally the same operating condition. The experiments were conducted on a modern four cylinder light-duty diesel engine that was modified with a port-fuel injection system while maintaining the stock direct injection fuel system. The pistons were modified for highly premixed operation and feature an open shallow bowl design. The results indicate that the authority to control the combustion phasing through the fuel delivery strategy (e.g., direct injection timing or premixed gasoline percentage) is not a strong function of the EHN concentration in the direct-injected fuel. It was also observed that NOx emissions are a strong function of the global EHN concentration in-cylinder and the combustion phasing. Finally, in general, NOx emissions are significantly elevated for gasoline/gasoline+EHN operation compared with gasoline/diesel RCCI operation at a given operating condition.« less

  13. Characterization of Reactivity Controlled Compression Ignition (RCCI) Using Premixed Gasoline and Direct-Injected Gasoline with a Cetane Improver on a Multi-Cylinder Engine

    SciTech Connect

    Dempsey, Adam B.; Curran, Scott; Reitz, Rolf D.

    2015-04-14

    The focus of the present paper was to characterize Reactivity Controlled Compression Ignition (RCCI) using a single-fuel approach of gasoline and gasoline mixed with a commercially available cetane improver on a multi-cylinder engine. RCCI was achieved by port-injecting a certification grade 96 research octane gasoline and direct-injecting the same gasoline mixed with various levels of a cetane improver, 2-ethylhexyl nitrate (EHN). The EHN volume percentages investigated in the direct-injected fuel were 10, 5, and 2.5%. The combustion phasing controllability and emissions of the different fueling combinations were characterized at 2300 rpm and 4.2 bar brake mean effective pressure over a variety of parametric investigations including direct injection timing, premixed gasoline percentage, and intake temperature. Comparisons were made to gasoline/diesel RCCI operation on the same engine platform at nominally the same operating condition. The experiments were conducted on a modern four cylinder light-duty diesel engine that was modified with a port-fuel injection system while maintaining the stock direct injection fuel system. The pistons were modified for highly premixed operation and feature an open shallow bowl design. The results indicate that the authority to control the combustion phasing through the fuel delivery strategy (e.g., direct injection timing or premixed gasoline percentage) is not a strong function of the EHN concentration in the direct-injected fuel. It was also observed that NOx emissions are a strong function of the global EHN concentration in-cylinder and the combustion phasing. Finally, in general, NOx emissions are significantly elevated for gasoline/gasoline+EHN operation compared with gasoline/diesel RCCI operation at a given operating condition.

  14. Summary of hydrogeologic controls on ground-water flow at the Nevada Test Site, Nye County, Nevada

    SciTech Connect

    Laczniak, R.J.; Cole, J.C.; Sawyer, D.A.; Trudeau, D.A.

    1996-07-01

    The underground testing of nuclear devices has generated substantial volumes of radioactive and other chemical contaminants below ground at the Nevada Test Site (NTS). Many of the more radioactive contaminants are highly toxic and are known to persist in the environment for thousands of years. In response to concerns about potential health hazards, the US Department of Energy, under its Environmental Restoration Program, has made NTS the subject of a long-term investigation. Efforts will assess whether byproducts of underground testing pose a potential hazard to the health and safety of the public and, if necessary, will evaluate and implement steps to remediate any of the identified dangers. Ground-water flow is the primary mechanism by which contaminants can be transported significant distances away from the initial point of injection. Flow paths between contaminant sources and potential receptors are separated by remote areas that span tens of miles. The diversity and structural complexity of the rocks along these flow paths complicates the hydrology of the region. Although the hydrology has been studied in some detail, much still remains uncertain about flow rates and directions through the fractured-rock aquifers that transmit water great distances across this arid region. Unique to the hydrology of NTS are the effects of underground testing, which severely alter local rock characteristics and affect hydrologic conditions throughout the region. This report summarizes what is known and inferred about ground-water flow throughout the NTS region. The report identifies and updates what is known about some of the major controls on ground-water flow, highlights some of the uncertainties in the current understanding, and prioritizes some of the technical needs as related to the Environmental Restoration Program. 113 refs.

  15. Admixture enhanced controlled low-strength material for direct underwater injection with minimal cross-contamination

    SciTech Connect

    Hepworth, H.K.; Davidson, J.S.; Hooyman, J.L.

    1997-03-01

    Commercially available admixtures have been developed for placing traditional concrete products under water. This paper evaluates adapting anti-washout admixture (AWA) and high range water reducing admixture (HRWRA) products to enhance controlled low-strength materials (CLSMs) for underwater placement. A simple experimental scale model (based on dynamic and geometric similitude) of typical grout pump emplacement equipment has been developed to determine the percentage of cementing material washed out. The objective of this study was to identify proportions of admixtures and underwater CLSM emplacement procedures which would minimize the cross-contamination of the displaced water while maintaining the advantages of CLSM. Since the displaced water from radioactively contaminated systems must be subsequently treated prior to release to the environment, the amount of cross-contamination is important for cases in which cementing material could form hard sludges in a water treatment facility and contaminate the in-place CLSM stabilization medium.

  16. Plasma gradient controlled injection and postacceleration of high quality electron bunches

    SciTech Connect

    Geddes, C. G. R.; Cormier-Michel, E.; Nakamura, K.; Schroeder, C. B.; Toth, Cs.; Esarey, E.; Plateau, G. R.; Bruhwiler, D. L.; Cary, J. R.; Leemans, W. P.

    2009-01-22

    Plasma density gradient control of wake phase velocity and trapping threshold in a laser wakefield accelerator produced electron bunches with absolute longitudinal and transverse momentum spreads more than ten times lower than in previous experiments (0.17 and 0.02 MeV/c FWHM, respectively) and with central momenta of 0.76{+-}0.02 MeV/c, stable over a week of operation. Simulations validated against diagnostics show that use of such bunches as a wakefield accelerator injector can produce stable beams with 0.2 MeV/c-class momentum spread at high energies. Preservation of bunch momentum spread requires high simulation momentum accuracy, and related self-trapped simulations showed that high order particle weight effectively suppresses simulation momentum errors allowing design of low emittance stages.

  17. Intake system for an electronic control fuel injection system for an internal combustion engine

    SciTech Connect

    Okuno, T.; Okabayashi, K.; Takahashi, K.; Sugimoto, K.

    1988-02-02

    An intake system for an internal combustion engine provided with a first camshaft for operating intake valves and a second camshaft for operating exhaust valves, the camshafts being covered by respective covers which form a recess therebetween is described comprising: a tubular throttle body; a throttle valve arranged in the throttle body for controlling an amount of air introduced into the engine; a surge tank having intake pipes extending therefrom and connected to respective cylinders of the engine; one end of a connection pipe being connected to the throttle body to receive air from the throttle body, the other end of the connection pipe being connected to the surge tank; at least one attachment member connected to the throttle valve; the throttle body together with at least one attachment member being bounded by a region formed between opposite longitudinal side portions of the respective covers and at least partially arranged in the recess between the covers of the respective camshafts.

  18. Paper 58714 - Exploring activated faults hydromechanical processes from semi-controled field injection experiments

    NASA Astrophysics Data System (ADS)

    Guglielmi, Y.; Cappa, F.; Nussbaum, C.

    2015-12-01

    The appreciation of the sensitivity of fractures and fault zones to fluid-induced-deformations in the subsurface is a key question in predicting the reservoir/caprock system integrity around fluid manipulations with applications to reservoir leakage and induced seismicity. It is also a question of interest in understanding earthquakes source, and recently the hydraulic behavior of clay faults under a potential reactivation around nuclear underground depository sites. Fault and fractures dynamics studies face two key problems (1) the up-scaling of laboratory determined properties and constitutive laws to the reservoir scale which is not straightforward when considering faults and fractures heterogeneities, (2) the difficulties to control both the induced seismicity and the stimulated zone geometry when a fault is reactivated. Using instruments dedicated to measuring coupled pore pressures and deformations downhole, we conducted field academic experiments to characterize fractures and fault zones hydromechanical properties as a function of their multi-scale architecture, and to monitor their dynamic behavior during the earthquake nucleation process. We show experiments on reservoir or cover rocks analogues in underground research laboratories where experimental conditions can be optimized. Key result of these experiments is to highlight how important the aseismic fault activation is compared to the induced seismicity. We show that about 80% of the fault kinematic moment is aseismic and discuss the complex associated fault friction coefficient variations. We identify that the slip stability and the slip velocity are mainly controlled by the rate of the permeability/porosity increase, and discuss the conditions for slip nucleation leading to seismic instability.

  19. Efficacy of a Multi-level Intervention to Reduce Injecting and Sexual Risk Behaviors among HIV-Infected People Who Inject Drugs in Vietnam: A Four-Arm Randomized Controlled Trial

    PubMed Central

    Go, Vivian F.; Frangakis, Constantine; Minh, Nguyen Le; Latkin, Carl; Ha, Tran Viet; Mo, Tran Thi; Sripaipan, Teerada; Davis, Wendy W.; Zelaya, Carla; Vu, Pham The; Celentano, David D.; Quan, Vu Minh

    2015-01-01

    Introduction Injecting drug use is a primary driver of HIV epidemics in many countries. People who inject drugs (PWID) and are HIV infected are often doubly stigmatized and many encounter difficulties reducing risk behaviors. Prevention interventions for HIV-infected PWID that provide enhanced support at the individual, family, and community level to facilitate risk-reduction are needed. Methods 455 HIV-infected PWID and 355 of their HIV negative injecting network members living in 32 sub-districts in Thai Nguyen Province were enrolled. We conducted a two-stage randomization: First, sub-districts were randomized to either a community video screening and house-to-house visits or standard of care educational pamphlets. Second, within each sub-district, participants were randomized to receive either enhanced individual level post-test counseling and group support sessions or standard of care HIV testing and counseling. This resulted in four arms: 1) standard of care; 2) community level intervention; 3) individual level intervention; and 4) community plus individual intervention. Follow-up was conducted at 6, 12, 18, and 24 months. Primary outcomes were self-reported HIV injecting and sexual risk behaviors. Secondary outcomes included HIV incidence among HIV negative network members. Results Fewer participants reported sharing injecting equipment and unprotected sex from baseline to 24 months in all arms (77% to 4% and 24% to 5% respectively). There were no significant differences at the 24-month visit among the 4 arms (Wald = 3.40 (3 df); p = 0.33; Wald = 6.73 (3 df); p = 0.08). There were a total of 4 HIV seroconversions over 24 months with no significant difference between intervention and control arms. Discussion Understanding the mechanisms through which all arms, particularly the control arm, demonstrated both low risk behaviors and low HIV incidence has important implications for policy and prevention programming. Trial Registration ClinicalTrials.gov NCT

  20. Controlled release of an osteogenic peptide from injectable biodegradable polymeric composites.

    PubMed

    Hedberg, Elizabeth L; Tang, Andrew; Crowther, Roger S; Carney, Darrell H; Mikos, Antonios G

    2002-12-05

    Poly(D,L-lactic-co-glycolic acid)/poly(ethylene glycol) (PLGA/PEG) blend microparticles loaded with the osteogenic peptide TP508 were added to a mixture of poly(propylene fumarate) (PPF), poly(propylene fumarate)-diacrylate (PPF-DA), and sodium chloride (NaCl) for the fabrication of PPF composite scaffolds that could allow for tissue ingrowth as well as for the controlled release of TP508 when implanted in an orthopedic defect site. In this study, PPF composites were fabricated and the in vitro release kinetics of TP508 were determined. TP508 loading within the PLGA/PEG microparticles, PEG content within the PLGA/PEG microparticles, the microparticle content of the PPF composite polymer component, and the leachable porogen initial mass percent of the PPF composites were varied according to a fractional factorial design and the effect of each variable on the release kinetics was determined for up to 28 days. Each composite formulation released TP508 with a unique release profile. The initial release (release through day 1) of the PLGA/PEG microparticles was reduced upon inclusion in the PPF composite formulations. Day 1 normalized cumulative mass release from PPF composites ranged from 0.14+/-0.01 to 0.41+/-0.01, whereas the release from PLGA/PEG microparticles ranged from 0.31+/-0.02 to 0.58+/-0.01. After 28 days, PPF composites released 53+/-4% to 86+/-2% of the entrapped peptide resulting in cumulative mass releases ranging from 0.14+/-0.01 microg TP508/mm(3) scaffold to 2.46+/-0.05 microg TP508/mm(3) scaffold. The results presented here demonstrate that PPF composites can be used for the controlled release of TP508 and that alterations in the composite's composition can lead to modulation of the TP508 release kinetics. These composites can be used to explore the effects varied release kinetics and dosages on the formation of bone in vivo.

  1. Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less

    PubMed Central

    Lin, S-M; Lin, C-J; Lin, C-C; Hsu, C-W; Chen, Y-C

    2005-01-01

    Aims: The aim of this study was to compare the outcomes of radiofrequency thermal ablation (RFTA), percutaneous ethanol injection (PEI), and percutaneous acetic acid injection (PAI) in the treatment of hepatocellular carcinoma (HCC). Patients and methods: A total of 187 patients with HCCs of 3 cm or less were randomly assigned to RFTA (n = 62), PEI (n = 62), or PAI (n = 63). Tumour recurrence and survival rates were assessed. Results: One, two, and three year local recurrence rates were 10%, 14%, and 14% in the RFTA group, 16%, 34%, and 34% in the PEI group, and 14%, 31%, and 31% in the PAI group (RFTA v PEI, p = 0.012; RFTA v PAI, p = 0.017). One, two, and three year survival rates were 93%, 81%, and 74% in the RFTA group, 88%, 66%, and 51% in the PEI group, and 90%, 67%, and 53% in the PAI group (RFTA v PEI, p = 0.031; RFTA v PAI, p = 0.038). One, two, and three year cancer free survival rates were 74%, 60%, and 43% in the RFTA group, 70%, 41%, and 21% in the PEI group, and 71%, 43%, and 23% in the PAI group (RFTA v PEI, p = 0.038; RFTA v PAI, p = 0.041). Tumour size, tumour differentiation, and treatment methods (RFTA v PEI and PAI) were significant factors for local recurrence, overall survival, and cancer free survival. Major complications occurred in 4.8% of patients (two with haemothorax, one gastric perforation) in the RFTA group and in none in two other groups (RFTA v PEI and PAI, p = 0.035). Conclusions: RFTA was superior to PEI and PAI with respect to local recurrence, overall survival, and cancer free survival rates, but RFTA also caused more major complications. PMID:16009687

  2. Effectiveness of music therapy: a summary of systematic reviews based on randomized controlled trials of music interventions

    PubMed Central

    Kamioka, Hiroharu; Tsutani, Kiichiro; Yamada, Minoru; Park, Hyuntae; Okuizumi, Hiroyasu; Tsuruoka, Koki; Honda, Takuya; Okada, Shinpei; Park, Sang-Jun; Kitayuguchi, Jun; Abe, Takafumi; Handa, Shuichi; Oshio, Takuya; Mutoh, Yoshiteru

    2014-01-01

    Objective The objective of this review was to summarize evidence for the effectiveness of music therapy (MT) and to assess the quality of systematic reviews (SRs) based on randomized controlled trials (RCTs). Study design An SR of SRs based on RCTs. Methods Studies were eligible if they were RCTs. Studies included were those with at least one treatment group in which MT was applied. We searched the following databases from 1995 to October 1, 2012: MEDLINE via PubMed, CINAHL (Cumulative Index of Nursing and Allied Health Literature), Web of Science, Global Health Library, and Ichushi-Web. We also searched all Cochrane Database and Campbell Systematic Reviews up to October 1, 2012. Based on the International Classification of Diseases, 10th revision, we identified a disease targeted for each article. Results Twenty-one studies met all inclusion criteria. This study included 16 Cochrane reviews. As a whole, the quality of the articles was very good. Eight studies were about “Mental and behavioural disorders (F00-99)”; there were two studies on “Diseases of the nervous system (G00-99)” and “Diseases of the respiratory system (J00-99)”; and there was one study each for “Endocrine, nutritional and metabolic diseases (E00-90)”, “Diseases of the circulatory system (I00-99)”, and “Pregnancy, childbirth and the puerperium (O60)”. MT treatment improved the following: global and social functioning in schizophrenia and/or serious mental disorders, gait and related activities in Parkinson’s disease, depressive symptoms, and sleep quality. Conclusion This comprehensive summary of SRs demonstrated that MT treatment improved the following: global and social functioning in schizophrenia and/or serious mental disorders, gait and related activities in Parkinson’s disease, depressive symptoms, and sleep quality. MT may have the potential for improving other diseases, but there is not enough evidence at present. Most importantly, no specific adverse effect or

  3. Nanostructure controlled sustained delivery of human growth hormone using injectable, biodegradable, pH/temperature responsive nanobiohybrid hydrogel

    NASA Astrophysics Data System (ADS)

    Singh, Narendra K.; Nguyen, Quang Vinh; Kim, Bong Sup; Lee, Doo Sung

    2015-02-01

    The clinical efficacy of a therapeutic protein, the human growth hormone (hGH), is limited by its short plasma half-life and premature degradation. To overcome this limitation, we proposed a new protein delivery system by the self-assembly and intercalation of a negatively charged hGH onto a positively charged 2D-layered double hydroxide nanoparticle (LDH). The LDH-hGH ionic complex, with an average particle size of approximately 100 nm, retards hGH diffusion. Nanobiohybrid hydrogels (PAEU/LDH-hGH) were prepared by dispersing the LDH-hGH complex into a cationic pH- and temperature-sensitive injectable PAEU copolymer hydrogel to enhance sustained hGH release by dual ionic interactions. Biodegradable copolymer hydrogels comprising poly(β-amino ester urethane) and triblock poly(ε-caprolactone-lactide)-poly(ethylene glycol)-poly-(ε-caprolactone-lactide) (PCLA-PEG-PCLA) were synthesized and characterized. hGH was self-assembled and intercalated onto layered LDH nanoparticles through an anion exchange technique. X-ray diffraction and zeta potential results showed that the LDH-hGH complex was prepared successfully and that the PAEU/LDH-hGH nanobiohybrid hydrogel had a disordered intercalated nanostructure. The biocompatibility of the nanobiohybrid hydrogel was confirmed by an in vitro cytotoxicity test. The in vivo degradation of pure PAEU and its nanobiohybrid hydrogels was investigated and it showed a controlled degradation of the PAEU/LDH nanobiohybrids compared with the pristine PAEU copolymer hydrogel. The LDH-hGH loaded injectable hydrogels suppressed the initial burst release of hGH and extended the release period for 13 days in vitro and 5 days in vivo. The developed nanohybrid hydrogel has the potential for application as a protein carrier to improve patient compliance.The clinical efficacy of a therapeutic protein, the human growth hormone (hGH), is limited by its short plasma half-life and premature degradation. To overcome this limitation, we proposed a new

  4. Control of emitted light polarization in a 1310 nm dilute nitride spin-vertical cavity surface emitting laser subject to circularly polarized optical injection

    SciTech Connect

    Alharthi, S. S. Hurtado, A.; Al Seyab, R. K.; Henning, I. D.; Adams, M. J.; Korpijarvi, V.-M.; Guina, M.

    2014-11-03

    We experimentally demonstrate the control of the light polarization emitted by a 1310 nm dilute nitride spin-Vertical Cavity Surface Emitting Laser (VCSEL) at room temperature. This is achieved by means of a combination of polarized optical pumping and polarized optical injection. Without external injection, the polarization of the optical pump controls that of the spin-VCSEL. However, the addition of the externally injected signal polarized with either left- (LCP) or right-circular polarization (RCP) is able to control the polarization of the spin-VCSEL switching it at will to left- or right-circular polarization. A numerical model has been developed showing a very high degree of agreement with the experimental findings.

  5. Summary of hydrogeologic controls on ground-water flow at the Nevada Test Site, Nye County, Nevada

    USGS Publications Warehouse

    Laczniak, R.J.; Cole, J.C.; Sawyer, D.A.; Trudeau, D.A.

    1996-01-01

    The underground testing of nuclear devices has generated substantial volumes of radioactive and other chemical contaminants below ground at the Nevada Test Site (NTS). Many of the more radioactive contaminants are highly toxic and are known to persist in the environment for thousands of years. In response to concerns about potential health hazards, the U.S. Department of Energy, under its Environmental Restoration Program, has made NTS the subject of a long-term investigation. Efforts supported through the U.S. Department of Energy program will assess whether byproducts of underground testing pose a potential hazard to the health and safety of the public and, if necessary, will evaluate and implement steps to remediate any of the identified dangers. Test-generated contaminants have been introduced over large areas and at variable depths above and below the water table throughout NTS. Evaluating the risks associated with these byproducts of underground testing presupposes a knowledge of the source, transport, and potential receptors of these contaminants. Ground-water flow is the primary mechanism by which contaminants can be transported significant distances away from the initial point of injection. Flow paths between contaminant sources and potential receptors are separated by remote areas that span tens of miles. The diversity and structural complexity of the rocks along these flow paths complicates the hydrology of the region. Although the hydrology has been studied in some detail, much still remains uncertain about flow rates and directions through the fractured-rock aquifers that transmit water great distances across this arid region. Unique to the hydrology of NTS are the effects of underground testing, which severely alter local rock characteristics and affect hydrologic conditions throughout the region. Any assessment of the risk must rely in part on the current understanding of ground-water flow, and the assessment will be only as good as the understanding

  6. Comparative effectiveness of dextrose prolotherapy versus control injections and exercise in the management of osteoarthritis pain: a systematic review and meta-analysis

    PubMed Central

    Hung, Chen-Yu; Hsiao, Ming-Yen; Chang, Ke-Vin; Han, Der-Sheng; Wang, Tyng-Guey

    2016-01-01

    Background Increasing evidence has supported the use of dextrose prolotherapy for patients with osteoarthritis. However, the real benefits may be affected by differences in injection protocols, comparative regimens, and evaluation scales. Methods PubMed and Scopus were searched from the earliest record until February 2016. One single-arm study and five randomized controlled trials were included, comprising 326 participants. We estimated the effect sizes of pain reduction before and after serial dextrose injections and compared the values between dextrose prolotherapy, comparative regimens, and exercise 6 months after the initial injection. Results Regarding the treatment arm using dextrose prolotherapy, the effect sizes compared with baseline were 0.65 (95% confidence interval [CI], 0.14–1.17), 0.84 (95% CI, 0.40–1.27), 0.85 (95% CI, 0.60–1.10), and 0.87 (95% CI, 0.53–1.21) after the first, second, third, and fourth or more injections, respectively. The overall effect of dextrose was better than control injections (effect size, 0.36; 95% CI, 0.10–0.63). Dextrose prolotherapy had a superior effect compared with local anesthesia (effect size, 0.38; 95% CI, 0.07–0.70) and exercise (effect size, 0.71; 95% CI, 0.30–1.11). There was an insignificant advantage of dextrose over corticosteroids (effect size, 0.31; 95% CI, –0.18 to 0.80) which was only estimated from one study. Conclusion Dextrose injections decreased pain in osteoarthritis patients but did not exhibit a positive dose–response relationship following serial injections. Dextrose prolotherapy was found to provide a better therapeutic effect than exercise, local anesthetics, and probably corticosteroids when patients were retested 6 months following the initial injection. PMID:27799816

  7. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.

    2011-01-01

    This column features summaries of five research articles relevant to school crisis response. The first, "High School Teachers' Experiences With Suicidal Students," summarized by Robyn Bratica, offers the results of a study examining high school teachers' experiences with suicidal students and suggests that contact with suicidal students is very…

  8. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.

    2012-01-01

    In this column, members of the NASP Crisis Management in the Schools Interest Group provide summaries of three studies relevant to school crisis response. The first study investigated the prevalence of posttraumatic stress disorder (PTSD) among rescue workers. The second article explored the Child and Family Traumatic Stress Intervention, which is…

  9. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.

    2009-01-01

    This article presents summaries of four recent crisis management publications: (1) "Crisis Intervention for Children/Caregivers Exposed to Intimate Partner Violence," summarized by Donna DeVaughn Kreskey; (2) "Predictors of Trauma Reactions Following the 9/11 Terrorist Attacks," summarized by Kelly O'Connor; (3) "Cognitive Coping Styles and PTSD…

  10. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.

    2009-01-01

    This article presents summaries of three recent crisis management publications: (1) "The Impact of School Violence on School Personnel," summarized by Kimberly de Deaux; (2) "Children Exposed to War/Terrorism," summarized by Jennifer DeFago; and (3) "Suicide Survivors Seeking Mental Health Services," summarized by Kimberly de Deaux. The first…

  11. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.

    2010-01-01

    This column features summaries of research articles from 3 recent crisis management publications. The first, "School Shootings and Counselor Leadership: Four Lessons from the Field" summarized by Kristi Fenning, was conducted as the result of the increased demand for trained crisis personnel on school campuses. Survey participants were…

  12. Research Summaries

    ERIC Educational Resources Information Center

    Brock, Stephen E., Ed.; Bratica, Robyn; Dempsey, Jack R.; Karle, Jessica

    2009-01-01

    This article presents summaries of recent crisis management publications. The first article summarized provides a review of research documenting that even when children are not physically proximal to a national disaster (9/11), they may still have negative reactions. The second article summarized is an examination of the PTSD diagnostic criterion…

  13. Golimumab Injection

    MedlinePlus

    ... body and causes pain, swelling, and damage) including: rheumatoid arthritis (condition in which the body attacks its own ... doctor.If golimumab injection is used to treat rheumatoid arthritis, it may also be injected intravenously (into a ...

  14. Adalimumab Injection

    MedlinePlus

    ... causes pain, swelling, and damage) including the following: rheumatoid arthritis (a condition in which the body attacks its ... If you are using adalimumab injection to treat rheumatoid arthritis, your doctor may tell you to inject the ...

  15. Aripiprazole Injection

    MedlinePlus

    ... aripiprazole injection and aripiprazole extended-release injection developed gambling problems or other intense urges or behaviors that ... even if you do not realize that your gambling or any other intense urges or unusual behaviors ...

  16. Teduglutide Injection

    MedlinePlus

    ... mix and inject it.Teduglutide comes as a kit containing vials of teduglutide powder for injection, prefilled syringes containing diluent (liquid to be mixed with teduglutide powder), needles to attach to the diluent syringe, dosing syringes ...

  17. Degarelix Injection

    MedlinePlus

    Degarelix injection is used to treat advanced prostate cancer (cancer that begins in the prostate [a male reproductive gland]). Degarelix injection is in a class of medications called gonadotropin-releasing hormone (GnRH) ...

  18. Cyclosporine Injection

    MedlinePlus

    ... injection is used with other medications to prevent transplant rejection (attack of the transplanted organ by the ... people who have received kidney, liver, and heart transplants. Cyclosporine injection should only be used to treat ...

  19. Colistimethate Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria. Colistimethate injection is in a class of medications called antibiotics. It works by killing bacteria.Antibiotics such as colistimethate injection will not work ...

  20. Chloramphenicol Injection

    MedlinePlus

    ... treat certain types of serious infections caused by bacteria when other antibiotics cannot be used. Chloramphenicol injection ... antibiotics. It works by stopping the growth of bacteria..Antibiotics such as chloramphenicol injection will not work ...

  1. Estrogen Injection

    MedlinePlus

    ... forms of estrogen injection are used to treat hot flushes (hot flashes; sudden strong feelings of heat and sweating) ... If you are using estrogen injection to treat hot flushes, your symptoms should improve within 1 to ...

  2. Etanercept Injection

    MedlinePlus

    ... areas causing pain and joint damage), chronic plaque psoriasis (a skin disease in which red, scaly patches ... etanercept injection is used to treat chronic plaque psoriasis, it may be injected twice a week during ...

  3. Levoleucovorin Injection

    MedlinePlus

    Levoleucovorin injection is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall) when methotrexate is used to to treat certain types of cancer. Levoleucovorin injection is also used to treat people ...

  4. Leucovorin Injection

    MedlinePlus

    Leucovorin injection is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to to treat certain types of cancer. Leucovorin injection is used to ...

  5. Teniposide Injection

    MedlinePlus

    ... in men. You should not become pregnant or breast-feed while you are receiving teniposide injection. If you or your partner become pregnant while receiving teniposide injection, call your doctor. Teniposide may harm the fetus.

  6. Ipilimumab Injection

    MedlinePlus

    ... are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving ipilimumab injection, call your doctor. Ipilimumab injection may cause your baby to be born too early or to die before birth.

  7. Pralatrexate Injection

    MedlinePlus

    Pralatrexate injection is used to treat peripheral T-cell lymphoma (PTCL; a form of cancer that begins in a ... come back after treatment with other medications. Pralatrexate injection has not been shown to help people who ...

  8. Cyanocobalamin Injection

    MedlinePlus

    Cyanocobalamin injection is used to treat and prevent a lack of vitamin B12 that may be caused by any ... organs) and permanent damage to the nerves. Cyanocobalamin injection also may be given as a test to ...

  9. Paclitaxel Injection

    MedlinePlus

    Paclitaxel injection manufactured with human albumin is used to treat breast cancer that has not improved or that has come back after treatment with other medications. Paclitaxel injection manufactured with polyoxyethylated castor oil is used to ...

  10. Diphenhydramine Injection

    MedlinePlus

    Diphenhydramine injection is used to treat allergic reactions, especially for people who are unable to take diphenhydramine by mouth. ... is used also to treat motion sickness. Diphenhydramine injection is also used alone or along with other ...

  11. Peramivir Injection

    MedlinePlus

    Peramivir injection is used to treat some types of influenza infection ('flu') in people who have had symptoms of ... flu for no longer than 2 days. Peramivir injection is in a class of medications called neuraminidase ...

  12. Cefotetan Injection

    MedlinePlus

    Cefotetan injection is used to treat infections of the lungs, skin, bones, joints, stomach area, blood, female reproductive organs, and urinary tract. Cefotetan injection is also used before surgery to prevent infections. ...

  13. Mipomersen Injection

    MedlinePlus

    Mipomersen injection is used to decrease levels of cholesterol and other fatty substances in the blood in people who ... that removes LDL from the blood), but mipomersen injection should not be used along with this treatment. ...

  14. Romiplostim Injection

    MedlinePlus

    Romiplostim injection is used to increase the number of platelets (cells that help the blood to clot) in order ... low number of platelets in the blood). Romiplostim injection should only be used in people who cannot ...

  15. Hydrocortisone Injection

    MedlinePlus

    Hydrocortisone injection is used to treat symptoms of low corticosteroid levels (lack of certain substances that are usually produced ... also used to treat severe allergic reactions. Hydrocortisone injection is used in the management of multiple sclerosis ( ...

  16. Palivizumab Injection

    MedlinePlus

    Palivizumab injection is used to help prevent respiratory syncytial virus (RSV; common virus that can cause serious lung infections) ... or have certain heart or lung diseases. Palivizumab injection is not used to treat the symptoms of ...

  17. Naltrexone Injection

    MedlinePlus

    Naltrexone injection is used along with counseling and social support to help people who have stopped drinking large amounts of alcohol to avoid drinking again. Naltrexone injection is also used along with counseling and social ...

  18. Tesamorelin Injection

    MedlinePlus

    Tesamorelin injection is used to decrease the amount of extra fat in the stomach area in adults with human ... fat in certain areas of the body). Tesamorelin injection is not used to help with weight loss. ...

  19. Testosterone Injection

    MedlinePlus

    ... and testosterone pellet (Testopel) are forms of testosterone injection used to treat symptoms of low testosterone in ... are low before you begin to use testosterone injection. Testosterone enanthate (Delatestryl) and testosterone pellet (Testopel) are ...

  20. Tigecycline Injection

    MedlinePlus

    Tigecycline injection used to treat certain serious infections including community acquired pneumonia (a lung infection that developed in a ... area between the chest and the waist). Tigecycline injection should not be used to treat pneumonia that ...

  1. Eculizumab Injection

    MedlinePlus

    Eculizumab injection is used to treat paroxysmal nocturnal hemoglobinuria (PNH: a type of anemia in which too many red ... oxygen to all parts of the body). Eculizumab injection is also used to treat atypical hemolytic uremic ...

  2. Pembrolizumab Injection

    MedlinePlus

    Pembrolizumab injection is used to treat melanoma (a type of skin cancer) that cannot be treated with surgery or ... spread to other parts of the body. Pembrolizumab injection is also used to treat a certain type ...

  3. Methylprednisolone Injection

    MedlinePlus

    ... allergic reactions. Methylprednisolone injection is used in the management of multiple sclerosis (a disease in which the ... laboratory test, tell your doctor and the laboratory personnel that you are using methylprednisolone injection.If you ...

  4. Obinutuzumab Injection

    MedlinePlus

    Obinutuzumab injection is used with chlorambucil (Leukeran) to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells). Obinutuzumab injection is in a class of medications called ...

  5. Busulfan Injection

    MedlinePlus

    Busulfex® Injection ... Busulfan injection is used to treat a certain type of chronic myelogenous leukemia (CML; a type of cancer of ... of 16 doses) before bone marrow transplant.Busulfan injection may cause seizures during therapy with the medication. ...

  6. Fuel injection system

    SciTech Connect

    Herth, H.; Kraus, B.; Sautter, W.; Wessel, W.

    1983-03-15

    A fuel injection system for an internal combustion engine includes electromagnetic injection valves controlled by a fuel control unit which receives signals from a camshaft actuated switch, a position-dependent throttle transducer and an oxygen sensor. When the oxygen sensor changes output levels, the transmission of this information is delayed, by the action of a switching transistor controlled by a monostable multivibrator, for a period of time equal to the internal time constant of the multivibrator.

  7. Single versus repetitive injection of lignocaine in the management of carpal tunnel syndrome--a randomized controlled trial.

    PubMed

    Akarsu, S; Karadaş, Ö; Tok, F; Levent Gül, H; Eroğlu, E

    2015-02-01

    The aim of this study was to determine the efficacy of single versus repetitive injection of lignocaine into the carpal tunnel for the management of carpal tunnel syndrome. The 42 patients included were randomly assigned to two Groups: group 1 was injected with 4 mL of 1% lignocaine once and Group 2 was injected with 4 mL of 1% lignocaine twice a week for 2 weeks. Clinical and electrophysiological evaluations were performed at the study onset, and at 6 and 12 weeks following the final injection. Initially, the groups were similar with respect to clinical and electrophysiological findings. All parameters in Group 2 improved 6 weeks post treatment (p < 0.05), and these improvements persisted at 12 weeks post treatment (p < 0.05). Repetitive local lignocaine injection was effective in reducing the symptoms of carpal tunnel syndrome and improving electrophysiological findings.

  8. Effect of prophylactic intraocular pressure-lowering medication (brinzolamide) on intraocular pressure after ranibizumab intravitreal injection: A case–control study

    PubMed Central

    Song, Shuang; Yu, Xiao-bing; Dai, Hong

    2016-01-01

    Purpose: To observe the effect of prophylactic intraocular pressure (IOP)-lowering medication (brinzolamide) on IOP after ranibizumab intravitreal injections (IVIs). Materials and Methods: This prospective case–control study included 352 eyes from 352 patients (1 eye per patient) who were treated with ranibizumab intravitreal injection and divided randomly into two groups. Two hundred and three patients in control group only received the ranibizumab IVI, but 149 patients in case group received one drop of prophylactic intraocular brinzolamide preinjection. The IOP was measured by noncontact tonometer before injection, at 10, 30, 120 min and 1 day after injection in a sitting position. Results: The mean IOP measured before injection, at 10, 30, 120 min and 1 day after injection individually were 15.79 ± 2.21 mmHg, 19.33 ± 4.86 mmHg, 16.64 ± 2.93 mmHg, 16.17 ± 3.13 mmHg, and 15.07 ± 2.55 mmHg in case group and were 15.82 ± 2.57 mmHg, 21.34 ± 5.88 mmHg, 18.17 ± 4.06 mmHg, 17.59 ± 4.42 mmHg, and15.48 ± 2.92 mmHg in control group. Comparing two groups, the mean increase on IOP was statistically significant at 10, 30, 120 min postinjection (P < 0.05). Conclusions: IVI of ranibizumab causes a considerable short-term transient rise on IOP in most patients. The effect of prophylactic IOP-lowering medication on IOP after IVIs can be statistically significant from 10 min to 2 h after IVIs. PMID:27905340

  9. Development of a new tracer-encapsulated solid pellet injection system for more precise control of tracer-impurity-deposit location in LHD

    NASA Astrophysics Data System (ADS)

    Tamura, N.; Shoji, M.; Suzuki, C.; Funaba, H.; Hayashi, H.; Maeno, H.; Yokota, M.; Ogawa, H.; Sudo, S.

    2016-11-01

    A new tracer-encapsulated solid pellet (TESPEL) injection system has been developed additionally for the LHD heliotron. This system has three-dimensionally bended guide tubes, which allows us to inject the TESPEL obliquely on a poloidal cross-section of the LHD plasma. Consequently, this system enables us to control a tracer-impurity-deposited location more precisely. Moreover, this system can make it possible for the tracer impurity to be deposited even only inside the ergodic region (outside a last closed flux surface of the LHD plasma). A stereoscopic fast camera system has been also developed for capturing a three-dimensional TESPEL trajectory.

  10. Interactional group discussion: results of a controlled trial using a behavioral intervention to reduce the use of injections in public health facilities.

    PubMed

    Hadiyono, J E; Suryawati, S; Danu, S S; Sunartono; Santoso, B

    1996-04-01

    Injections are commonly overused in Indonesia. More than 60% of patients attending public health facilities receive at least one injection, which increases clinical risk and has adverse economic impact. This study assesses the efficacy of an innovative behavioral intervention, the Interactional Group Discussion (IGD), for reducing the overuse of injections. This study was a controlled trial in a single district with 24 public health centers randomized to intervention and control groups. Prescribers in the intervention group were invited to one IGD, each of which consisted of 6 prescribers and 6 patients; a total of 24 IGDs were held in a 4-week period, and all invited prescribers participated. The groups, which lasted 90-120 minutes, were facilitated by a behavioral scientist and a clinician, who also served as a scientific resource person. The hypothesized mechanism of behavior change involved reality testing prescribers' assumptions about patient beliefs, imparting scientific information about injection efficacy, and establishing peer norms about correct behavior. Outcomes were measured by a retrospective prescribing survey covering the periods 3 months before and 3 months after the intervention, with samples of 100 prescriptions per center per month. Rates of injection and average number of drugs per prescription were computed separately for each center, and t-tests were used to compare pre-post changes in outcomes in both groups. Results showed a significant decrease in injection use from 69.5 to 42.3% in the intervention group, compared to a decrease from 75.6 to 67.1% among controls [-18.7.0% intervention vs control, 95% CI = (-31.1%, -6.4%), P < 0.025]. There was also a significant reduction in average number of drugs per prescription [-0.37 drugs prescribed per patient, 95% CI = (-0.04, -0.52), P < 0.05], indicating that injections were not substituted with other drugs. We conclude that the IGD significantly reduces the overuse of injections. It is

  11. Has aidi injection the attenuation and synergistic efficacy to gemcitabine and cisplatin in non-small cell lung cancer? A meta-analysis of 36 randomized controlled trials

    PubMed Central

    Xiao, Zheng; Wang, Chengqiong; Chen, Ling; Tang, Xuemei; Li, Lianhong; Li, Nana; Li, Jing; Gong, Qihai; Tang, Fushan; Feng, Jihong; Li, Xiaofei

    2017-01-01

    Gemcitabine and cisplatin is the first line chemotherapy for non-small cell lung cancer with high toxicity. Aidi injection is a cantharidin and astragalu-based Chinese herbs injection in China. Has Aidi injection attenuation and synergistic efficacy to GP in NSCLC? There is lack of strong evidence to prove it. To further reveal it, we systematically evaluated all related studies. We collected all studies about Aidi injection plus GP for NSCLC in Medline, Embase, Web of Science, CNKI, VIP, Wanfang Database, CBM, CCRCT, Chi-CTR, and US-clinical trials (established to June 2015). We evaluated their quality according to the Cochrane evaluation handbook of randomized controlled trials (5.1.0), extracted data following the PICO principles and synthesized the data by Meta analysis. Thirty six RCTs with 2582 NSCLC patients were included, with general methodological quality in most trials. The RR values and their 95% CI of Meta-analysis for ORR, DCR and QOL were as following: 1.28 (1.17, 1.39), 1.11(1.07, 1.15) and 1.81 (1.61, 2.03). The merged RD values and their 95% CI of Meta-analysis for myelosuppression, neutropenia, thrombocytopenia, neurotoxicity and nausea and vomiting were as following: -0.23(-0.29, -0.17), -0.17(-0.22, -0.11), -0.13(-0.18, -0.08), -0.06(-0.17, 0.05) and -0.15(-0.21, -0.10). To compare with GP alone, all differences were statistically significant. The available evidence indicates that Aidi injection plus GP can significantly increase the clinical efficacy and improve the QOL of patients with NSCLC. Aidi injection can reduce myelosuppression, neutropenia, thrombocytopenia neurotoxicity and nausea/vomiting. These indirectly reveal that Aidi injection has the attenuation and synergistic efficacy to GP chemotherapy in NSCLC. PMID:27901493

  12. Gate-voltage controlled spin pumping effects: spin injection from YIG and Co into metal and graphene based 2 D materials

    NASA Astrophysics Data System (ADS)

    Kalitsov, Alan; Chshiev, Mairbek; Mryasov, Oleg

    2015-03-01

    Spin current injection into nonmagnetic metals, semiconductors and oxides is crucial component of spintronics. The spin pumping mechanism free from the impedance mismatch is a promising way to inject spin current into nonmagnetic materials. Here we present theory of spin current injected into non-magnetic films which arises from magnetization precession. We apply this theory to two cases (i) insulating yttrium iron garnet ferromagnet/nonmagnetic metal interfaces and (ii) hcp-Co/single layer graphene interface. The electron transport calculations are based on the non-equilibrium Green Function formalism within the tight binding Hamiltonian model. We show that magnitude of the pumped spin current can be efficiently controlled by the gate voltage.

  13. Large-scale synthesis of the controlled-geometry carbon coils by the manipulation of the SF6 gas flow injection time.

    PubMed

    Eum, Jun-Ho; Kim, Sung-Hoon; Yi, Soung Soo; Jang, Kiwan

    2012-05-01

    Carbon coils could be synthesized using C2H2/H2 as source gases and SF6 as an incorporated additive gas under thermal chemical vapor deposition system. Nickel catalyst layer deposition and then hydrogen plasma pretreatment were performed prior to the carbon coils deposition reaction. According to the different reaction processes, the injection time of SF6 gas flow was varied. The characteristics (formation density, morphology, and geometry) of the deposited carbon coils on the substrates were investigated according to the different reaction processes. Finally, the large-scale synthesis of carbon coils and their geometry control could be achieved merely by manipulating SF6 gas flow injection time. Three cases growth aspects were proposed according to SF6 gas flow injection time in association with the fluorine's characteristics for etching the materials or enhancing the nucleation sites.

  14. OnabotulinumtoxinA Urethral Sphincter Injection as Treatment for Non-neurogenic Voiding Dysfunction – A Randomized, Double-Blind, Placebo-Controlled Study

    PubMed Central

    Jiang, Yuan-Hong; Wang, Chung-Cheng; Kuo, Hann-Chorng

    2016-01-01

    Non-neurogenic voiding dysfunction including dysfunctional voiding and detrusor underactivity caused by a spastic or non-relaxing external urethral sphincter can theoretically be treated by injections of botulinum A toxin into the external urethral sphincter. This randomized, double-blind, placebo-controlled trial was designed to determine the clinical efficacy of onabotulinumtoxinA urethral sphincter injections in patients with dysfunctional voiding or detrusor underactivity. Patients with medically refractory dysfunctional voiding (n = 31) or detrusor underactivity (n = 31) were randomly allocated in a 2:1 ratio to receive either onabotulinumtoxinA (100 U) (n = 38) or placebo (normal saline) (n = 24). There were no significant differences in subjective or objective parameters between patients who received onabotulinumtoxinA and those who received saline injection therapy, and the overall success rate was 43.5% (reduction in Patient perception of Bladder Condition by ≥2: onabotulinumtoxinA 36.8% vs placebo 54.2%, p = 0.114). The results were similar between the dysfunctional voiding and detrusor underactivity subgroups; however, a significant reduction in detrusor voiding pressure was only observed in dysfunctional voiding patients who received onabotulinumtoxinA. Repeat urethral sphincter onabotulinumtoxinA injections offered greater therapeutic effects in both dysfunctional voiding and detrusor underactivity patients. For patients with non-neurogenic voiding dysfunction, the success rate of onabotulinumtoxinA urethral sphincter injection was not superior to placebo. PMID:27958325

  15. More than just someone to inject drugs with: injecting within primary injection partnerships

    PubMed Central

    Morris, Meghan D.; Bates, Anna; Andrew, Erin; Hahn, Judith; Page, Kimberly; Maher, Lisa

    2015-01-01

    Background Studies have shown intimate injection partners engage in higher rates of syringe and injecting equipment sharing. We examined the drug use context and development of injection drug use behaviors within intimate injection partnerships. Methods In-depth interviews (n=18) were conducted with both members of nine injecting partnerships in Sydney, Australia. Content analysis identified key domains related to the reasons for injecting with a primary injection partner and development of drug injection patterns. Main Findings Most partnerships (n=5) were also sexual; three were blood-relatives and one a friend dyad. The main drug injected was heroin (66%) with high rates of recent sharing behaviors (88%) reported within dyads. Injecting within a primary injection partnership provided perceived protection against overdose events, helped reduce stress, increased control over when, where, and how drugs were used, and promoted the development of an injecting pattern where responsibilities could be shared. Unique to injecting within primary injection partnerships was the social connection and companionship resulted in a feeling of fulfillment while also blinding one from recognizing risky behavior. Conclusions Findings illuminated the tension between protection and risks within primary injection partnerships. Primary injection partnerships provide a potential platform to expand risk reduction strategies. PMID:26460140

  16. Design, fabrication and test of a pneumatically controlled, renewable, microfluidic bead trapping device for sequential injection analysis applications

    SciTech Connect

    Shao, Guocheng; Lu, Donglai; Fu, Zhifeng; Du, Dan; Ozanich, Richard M.; Wang, Wanjun; Lin, Yuehe

    2016-01-01

    This paper describes the design, fabrication, and testing of a pneumatically controlled,renewable, microfluidic device for conducting bead-based assays in an automated sequential injection analysis system. The device used a “brick wall”-like pillar array (pillar size: 20 μm length X 50 μm width X 45 μm height) with 5 μm gaps between the pillars serving as the micro filter. The flow channel where bead trapping occurred is 500 μm wide X 75 μm deep. An elastomeric membrane and an air chamber were located underneath the flow channel. By applying pressure to the air chamber, the membrane is deformed and pushed upward against the filter structure. This effectively traps beads larger than 5 μm and creates a “bed” or micro column of beads that can be perfused and washed with liquid samples and reagents. Upon completion of the assay process, the pressure is released and the beads are flushed out from underneath the filter structure to renew the device. Mouse IgG was used as a model analyte to test the feasibility of using the proposed device for immunoassay applications. Resulting microbeads from an on-chip fluorescent immunoassay were individually examined using flow cytometry. The results show that the fluorescence signal intensity distribution is fairly narrow indicating high chemical reaction uniformity among the beads population. Electrochemical onchip assay was also conducted. A detection limit of 0.1 ng/mL1 ppb was achieved and good device reliability and repeatability were demonstrated. The novel microfluidic-based beadstrapping device thus opens up a new pathway to design micro-bead based biosensor immunoassays for clinical and othervarious applications.

  17. Comparative Evaluation of Preemptive Analgesic Effect of Injected Intramuscular Diclofenac and Ketorolac after Third Molar Surgery- A Randomized Controlled Trial

    PubMed Central

    Mony, Deepthi; Kulkarni, Deepak

    2016-01-01

    Introduction Analgesia pre-emptively administered effect-ively aid in management of pain. Pre-emptive analgesia is anti-nociceptive treatment which prevents altered central sensitization of afferent inputs. Aim To compare and evaluate the pre-emptive analgesic efficacy of preoperatively administered ketorolac and diclofenac for controlling postoperative pain after third molar surgery. Materials and Methods A total of 50 patients with symmetrically impacted third molars were divided into two groups, 30mg intramuscular injection of ketorolac and 75 mg diclofenac sodium were used in the respective groups. The visual analogue scale was used to assess post operative pain for three days and the patients were also evaluated for the number of rescue analgesia. Results The data was statistically evaluated with paired t- test. The maximum time taken for pain perception for Group A Ketoralac was 5.48 hrs and Group B Diclofenac sodium was 4.9 hrs and p=0.235 which was not significant. The mean number of tablets taken by the patients in the first three post operative days was 3.24 in Group A i.e., Ketorolac and 4.04 in Group B i.e., Diclofenac sodium. The values were compared using the paired t test. The p value = 0.004, which was significant. Conclusion Ketoralac showed better pre-emptive analgesic effect for post-operative pain management after third molar extraction. The immediate post-operative pain free period provided by both ketorolac and diclofenac by intramuscular route was same. PMID:27504398

  18. Investigation and demonstration of dry carbon-based sorbent injection for mercury control. Quarterly report, November 1, 1995--December 31, 1995

    SciTech Connect

    Hunt, T.; Sjostrom, S.

    1996-02-05

    The overall objective to this two phase program is to investigate dry carbon-based sorbents for mercury control. During Phase I, a bench-scale field test device that can simulate an electrostatic precipitator, a pulse-jet baghouse, or a reverse-gas baghouse will be designed and integrated with an existing pilot-scale facility at Public Service Company of Colorado`s (PSCo`s) Comanche station. Various sorbents will then be injected to determine the mercury removal efficiency for each. During Phase II effort, component integration of the most promising technologies shall be tested at the 5000 acfm pilot-scale. The primary task currently underway is the facility design. The design is expected to be finished in January, 1996. The facility, regardless of the particulate control module configuration, will be fitted with supply line injection port, through which mercury sorbents and SO{sub 2} control sorbents can be added to the flue gas stream.

  19. Musculoskeletal Injection

    PubMed Central

    Wittich, Christopher M.; Ficalora, Robert D.; Mason, Thomas G.; Beckman, Thomas J.

    2009-01-01

    Patients commonly present to primary care physicians with musculoskeletal symptoms. Clinicians certified in internal medicine must be knowledgeable about the diagnosis and management of musculoskeletal diseases, yet they often receive inadequate postgraduate training on this topic. The musculoskeletal problems most frequently encountered in our busy injection practice involve, in decreasing order, the knees, trochanteric bursae, and glenohumeral joints. This article reviews the clinical presentations of these problems. It also discusses musculoskeletal injections for these problems in terms of medications, indications, injection technique, and supporting evidence from the literature. Experience with joint injection and the pharmacological principles described in this article should allow primary care physicians to become comfortable and proficient with musculoskeletal injections. PMID:19720781

  20. Effects of Bee Venom Injections at Acupoints on Neurologic Dysfunction Induced by Thoracolumbar Intervertebral Disc Disorders in Canines: A Randomized, Controlled Prospective Study

    PubMed Central

    Tsai, Li-Chuan; Lin, Yi-Wen; Hsieh, Ching-Liang

    2015-01-01

    Intervertebral disk disease (IVDD) is a major spine disorder in canines that causes neurological dysfunction, particularly in the thoracolumbar area. Analgesic and anti-inflammatory drugs are typically used to reduce nociceptive signals to decrease canine suffering. Bee venom (BV) has been reported to exert anti-inflammatory and analgesic effects. Injection of BV at acupoints has been widely used to treat clinical disorders including inflammation, pain, and arthritis. The current study was intended to determine whether BV injections at acupoints can enhance treatment of canine neurological dysfunction caused by IVDD. A single-blind controlled trial involving 40 adult canines with neurological dysfunction induced by IVDD subdivided into 2 groups was designed, and 36 canines finished the study. The myelopathy scoring system (MSS) grade and functional numeric scale (FNS) scores improved further after BV treatment than after control treatment. BV injection exerted a particularly strong effect on canines with moderate to severe IVDD and dramatically reduced clinical rehabilitation time. The results indicate that BV injections at acupoints are more effective at protecting canines from IVDD-induced neurological dysfunction and pain than is treatment alone. PMID:26693480

  1. Comparison of Periodontal Ligament Injection and Inferior Alveolar Nerve Block in Mandibular Primary Molars Pulpotomy: A Randomized Control Trial

    PubMed Central

    Haghgoo, Roza; Taleghani, Ferial

    2015-01-01

    Background: Inferior alveolar nerve block is a common technique for anesthesia of the primary mandibular molars. A number of disadvantages have been shown to be associated with this technique. Periodontal ligament (PDL) injection could be considered as an alternative to inferior alveolar nerve block. The aim of this study was to evaluate the effectiveness of PDL injection in the anesthesia of primary molar pulpotomy with mandibular block. Methods: This study was performed using a sequential double-blind randomized trial design. 80 children aged 3-7 years old who required pulpotomy in symmetrical mandibular primary molars were selected. The teeth of these children were anesthetized with periodontal injection on one side of the mandible and block on the other. Pulpotomy was performed on each patient during the same appointment. Signs of discomfort, including hand and body tension and eye movement, the verbal complaint and crying (SEM scale), were evaluated by a dental assistant who was blinded to the treatment allocation of the patients. Finally, the data were analyzed using the exact Fisher test and Pearson Chi-squared exact test. Results: Success rate was 88/75 and 91/25 in the PDL injection and nerve block groups, respectively. There was no statistically significant difference between the two techniques (P = 0.250). Conclusion: Results showed that PDL injection can be used as an alternative to nerve block in pulpotomy of the mandibular primary molars. PMID:26028895

  2. Summary report: A preliminary investigation into the use of fuzzy logic for the control of redundant manipulators

    NASA Technical Reports Server (NTRS)

    Cheatham, John B., Jr.; Magee, Kevin N.

    1991-01-01

    The Rice University Department of Mechanical Engineering and Materials Sciences' Robotics Group designed and built an eight degree of freedom redundant manipulator. Fuzzy logic was proposed as a control scheme for tasks not directly controlled by a human operator. In preliminary work, fuzzy logic control was implemented for a camera tracking system and a six degree of freedom manipulator. Both preliminary systems use real time vision data as input to fuzzy controllers. Related projects include integration of tactile sensing and fuzzy control of a redundant snake-like arm that is under construction.

  3. Potential Risk Factors for Injecting Among Mexican American Non-Injecting Heroin Users

    PubMed Central

    Valdez, Avelardo; Neaigus, Alan; Cepeda, Alice

    2008-01-01

    SUMMARY This study examines potential risk factors for resuming and transitioning to injecting among a prospective cohort of 300 Mexican American non-injecting heroin users (NIUs) with distinct injecting histories (i.e., never vs. former injectors). Overall. findings revealed NIUs with an injecting history are more likely to be at greater risk for resuming injecting practices. Of interest, scoring high on acculturation decreased the risk of being a former injector. The present analysis supports previous research, and more importantly further identifies potential risk factors for injecting that are unique to the cultural and social context of the Mexican American community. PMID:18192204

  4. Mortality Risk Associated With Long-acting Injectable Antipsychotics: A Systematic Review and Meta-analyses of Randomized Controlled Trials.

    PubMed

    Kishi, Taro; Matsunaga, Shinji; Iwata, Nakao

    2016-11-01

    Long-acting injectable (LAI) antipsychotics (LAI-APs) have several advantages over oral medications, but deaths reported in Japan during the early post-marketing phase vigilance period have raised safety concerns. We conducted a series of meta-analyses to assess whether LAI-APs affect the mortality of patients with schizophrenia. Three categorical meta-analyses of randomized controlled trials (RCTs) were performed to compare all-cause death (primary outcome) and death due to suicide: individual and pooled LAI-APs vs placebo, individual and pooled LAI-APs vs oral antipsychotics (OAPs), and head-to-head comparisons of LAI-APs. The risk ratios (RRs) and 95% CIs were calculated. We identified 52 RCTs (53 comparisons; total participants = 17 416, LAI-APs = 11 360, OAP = 3910, and placebo = 2146; mean study duration [wk]: LAI-APs vs placebo = 28.9, LAI-APs vs OAPs = 64.5). Neither pooled nor individual LAI-APs (aripiprazole, fluphenazine, olanzapine, paliperidone, and risperidone) differed from the placebo regarding the incidences of all-cause death (pooled LAI-APs: RR = 0.64, P = .37) and death due to suicide (pooled LAI-APs: RR = 0.98, P = .98). However, in a subgroup meta-analysis of only short-duration RCTs (≤13wk), pooled LAI-APs exhibited a trend toward lower incidence of all-cause death than placebo (RR = 0.29, P = .08). Pooled LAI-APs (aripiprazole, fluphenazine, haloperidol, olanzapine, paliperidone, risperidone, and zuclopenthixol) did not differ from pooled OAPs regarding all-cause death (pooled LAI-APs: RR = 0.71, P = .30) and death due to suicide (pooled LAI-APs: RR = 0.94, P = .91). Individual LAI-APs and OAPs were associated with similar risks of death. Data for head-to-head comparisons of individual LAI-APs were insufficient. In conclusion, there was no significant difference between LAI-APs and placebo or OAPs regarding all-cause death and death due to suicide.

  5. Miniscalpel-Needle versus Steroid Injection for Plantar Fasciitis: A Randomized Controlled Trial with a 12-Month Follow-Up

    PubMed Central

    Li, Shuming; Shen, Tong; Liang, Yongshan; Zhang, Ying; Bai, Bo

    2014-01-01

    Plantar fasciitis is the most common cause of heel pain in adults. A novel alternative medical instrument, the miniscalpel-needle (MSN), which is based on an acupuncture needle, has been recently developed in China. The objective of this study was to evaluate the effectiveness of the MSN release treatment versus that of traditional steroid injection for plantar fasciitis. Patients with plantar fasciitis were randomly assigned to 2 groups and followed up for 12 months, with 29 receiving MSN treatment and 25 receiving steroid injection treatment. The results showed that visual analog scale scores for morning pain, active pain, and overall heel pain all were decreased significantly in the MSN group from 1 to 12 months after treatment. In contrast, treatment with steroid injection showed a significant effect only at the 1-month follow-up but not at 6 or 12 months after treatment. Moreover, the MSN group achieved more rapid and sustained improvements than the steroid group throughout the duration of this study. No severe side effects were observed with MSN treatment. Our data suggest that the MSN release treatment is safe and has a significant benefit for plantar fasciitis compared to steroid injection. PMID:25114704

  6. Certolizumab Injection

    MedlinePlus

    ... has not improved when treated with other medications, rheumatoid arthritis (a condition in which the body attacks its ... continues. When certolizumab injection is used to treat rheumatoid arthritis, it is usually given every other week and ...

  7. Natalizumab Injection

    MedlinePlus

    ... prevent episodes of symptoms in people who have Crohn's disease (a condition in which the body attacks the ... If you are receiving natalizumab injection to treat Crohn's disease, your symptoms should improve during the first few ...

  8. Vedolizumab Injection

    MedlinePlus

    ... injection may cause serious allergic reactions during an infusion and for several hours afterward. A doctor or ... of the following symptoms during or after your infusion: rash; itching; swelling of the face, eyes, mouth, ...

  9. Panitumumab Injection

    MedlinePlus

    ... as a solution (liquid) to be given by infusion (injected into a vein). It is usually given ... doctor or nurse in a doctor's office or infusion center. Panitumumab is usually given once every 2 ...

  10. Methotrexate Injection

    MedlinePlus

    ... woman's uterus while she is pregnant), breast cancer, lung cancer, certain cancers of the head and neck; certain ... Methotrexate injection is also used along with rest, physical therapy and ... treat rheumatoid arthritis by decreasing the activity of the immune system.

  11. Alirocumab Injection

    MedlinePlus

    ... injection is used along with diet and certain cholesterol-lowering medications (HMG-CoA reductase inhibitors [statins]) in ... familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally) or ...

  12. Evolocumab Injection

    MedlinePlus

    ... injection is used along with diet and certain cholesterol-lowering medications, HMG-CoA reductase inhibitors (statins), in ... heterozygous hypercholesterolemia (HeFH; an inherited condition in which cholesterol cannot be removed from the body normally) or ...

  13. Pentamidine Injection

    MedlinePlus

    Pentamidine injection is used to treat pneumonia caused by a fungus called Pneumocystis carinii. It is in a class of medications called antiprotozoals. It works by stopping the growth of protozoa that can cause pneumonia.

  14. Oxytocin Injection

    MedlinePlus

    Oxytocin injection is used to begin or improve contractions during labor. Oxytocin also is used to reduce bleeding after childbirth. ... other medications or procedures to end a pregnancy. Oxytocin is in a class of medications called oxytocic ...

  15. Ibritumomab Injection

    MedlinePlus

    ... is in a class of medications called monoclonal antibodies with radioisotopes. It works by attaching to cancer ... you receive ibritumomab injection, your body may develop antibodies (substances in the blood that help the immune ...

  16. Ganciclovir Injection

    MedlinePlus

    ... problems, eye problems other than CMV retinitis, or kidney disease.tell your doctor if you are pregnant or plan to become pregnant. Ganciclovir injection may cause infertility (difficulty becoming pregnant). However, if you are a ...

  17. Bendamustine Injection

    MedlinePlus

    ... a type of cancer of the white blood cells). Bendamustine injection is also used to treat a ... that begins in a type of white blood cell that normally fights infection) that is slow spreading, ...

  18. Vancomycin Injection

    MedlinePlus

    ... medications called glycopeptide antibiotics. It works by killing bacteria that cause infections.Antibiotics such as vancomycin injection ... infection may not be completely treated and the bacteria may become resistant to antibiotics.

  19. Levofloxacin Injection

    MedlinePlus

    ... of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections.Antibiotics such as levofloxacin injection ... infection may not be completely treated and the bacteria may become resistant to antibiotics.

  20. Doxycycline Injection

    MedlinePlus

    ... medications called tetracycline antibiotics. It works by killing bacteria that cause infections.Antibiotics such as doxycycline injection ... infection may not be completely treated and the bacteria may become resistant to antibiotics.

  1. Sumatriptan Injection

    MedlinePlus

    ... accompanied by nausea and sensitivity to sound and light). Sumatriptan injection is also used to treat the ... children. Store it at room temperature, away from light, excess heat, and moisture (not in the bathroom). ...

  2. Alemtuzumab Injection

    MedlinePlus

    ... injection, the medication is usually given three times weekly on alternate days (usually Monday, Wednesday, and Friday) ... that you eat foods that are rich in iron such as meats, leafy green vegetables, and fortified ...

  3. Epinephrine Injection

    MedlinePlus

    Epinephrine injection is used along with emergency medical treatment to treat life-threatening allergic reactions caused by ... or stings, foods, medications, latex, and other causes. Epinephrine is in a class of medications called alpha- ...

  4. Mitoxantrone Injection

    MedlinePlus

    ... medications to relieve pain in people with advanced prostate cancer who did not respond to other medications. Mitoxantrone ... doses). When mitoxantrone injection is used to treat prostate cancer, it is usually given once every 21 days. ...

  5. Trastuzumab Injection

    MedlinePlus

    ... with other medications to treat certain types of stomach cancer that have spread to other parts of the ... weeks. When trastuzumab injection is used to treat stomach cancer, it is usually given once every 3 weeks. ...

  6. Topotecan Injection

    MedlinePlus

    ... organs where eggs are formed) and small cell lung cancer (a type of cancer that begins in the ... topotecan injection is used to treat ovarian or lung cancer, it is usually given once a day for ...

  7. Palonosetron Injection

    MedlinePlus

    ... that may occur several days after receiving certain chemotherapy medications. Palonosetron injection is in a class of medications called 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural ...

  8. Meropenem Injection

    MedlinePlus

    ... skin and abdominal (stomach area) infections caused by bacteria and meningitis (infection of the membranes that surround ... of medications called antibiotics. It works by killing bacteria that cause infection.Antibiotics such as meropenem injection ...

  9. Amikacin Injection

    MedlinePlus

    ... treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that ... medications called aminoglycoside antibiotics. It works by killing bacteria.Antibiotics such as amikacin injection will not work ...

  10. Ertapenem Injection

    MedlinePlus

    ... abdominal (stomach area) infections, that are caused by bacteria. It is also used for the prevention of ... medications called carbapenem antibiotics. It works by killing bacteria.Antibiotics such as ertapenem injection will not work ...

  11. Moxifloxacin Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria such as pneumonia; ; and , skin, and abdominal (stomach ... antibiotics called fluoroquinolones. It works by killing the bacteria that cause infections.Antibiotics such as moxifloxacin injection ...

  12. Cefepime Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria including pneumonia, and skin, urinary tract, and kidney ... medications called cephalosporin antibiotics. It works by killing bacteria.Antibiotics such as cefepime injection will not work ...

  13. Cefazolin Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria including skin, bone, joint, genital, blood, heart valve, ... medications called cephalosporin antibiotics. It works by killing bacteria.Antibiotics such as cefazolin injection will not work ...

  14. Daptomycin Injection

    MedlinePlus

    ... blood infections or serious skin infections caused by bacteria. Daptomycin injection is in a class of medications called cyclic lipopeptide antibiotics. It works by killing bacteria. Antibiotics will not work for treating colds, flu, ...

  15. Aztreonam Injection

    MedlinePlus

    ... to treat certain infections that are caused by bacteria, including respiratory tract (including pneumonia and bronchitis), urinary ... abdominal (stomach area) infections, that are caused by bacteria. Aztreonam injection also may be used before, during, ...

  16. Ceftazidime Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria including pneumonia and other lower respiratory tract (lung) ... medications called cephalosporin antibiotics. It works by killing bacteria.Antibiotics such as ceftazidime injection will not work ...

  17. Tobramycin Injection

    MedlinePlus

    ... treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that ... medications called aminoglycoside antibiotics. It works by killing bacteria.Antibiotics such as tobramycin injection will not work ...

  18. Ciprofloxacin Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria such as pneumonia; and infections of the skin, ... of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections.Antibiotics such as ciprofloxacin injection ...

  19. Gentamicin Injection

    MedlinePlus

    ... treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that ... medications called aminoglycoside antibiotics. It works by killing bacteria.Antibiotics such as gentamicin injection will not work ...

  20. Ceftaroline Injection

    MedlinePlus

    ... infections and pneumonia (lung infection) caused by certain bacteria. Ceftaroline is in a class of medications called cephalosporin antibiotics. It works by killing bacteria.Antibiotics such as ceftaroline injection will not work ...

  1. Daclizumab Injection

    MedlinePlus

    ... course of disease where symptoms flare up from time to time) of multiple sclerosis (MS; a disease in which ... injections. Before you use daclizumab yourself the first time, read the written instructions that come with it. ...

  2. Risperidone Injection

    MedlinePlus

    ... release (long-acting) injection is used to treat schizophrenia (a mental illness that causes disturbed or unusual ... do not already have diabetes. If you have schizophrenia, you are more likely to develop diabetes than ...

  3. Acyclovir Injection

    MedlinePlus

    ... chickenpox in the past) in people with weak immune systems. It is also used to treat first-time ... from time to time) in people with normal immune systems. Acyclovir injection is used to treat herpes simplex ...

  4. Omalizumab Injection

    MedlinePlus

    ... steroids. Omalizumab is also used to treat chronic hives without a known cause that cannot successfully be ... is not used to treat other forms of hives or allergic conditions. Omalizumab injection is in a ...

  5. Pegloticase Injection

    MedlinePlus

    ... doctor if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency (an inherited blood disease). Your doctor may test you for G6PD deficiency before you start to receive pegloticase injection. If ...

  6. Oxacillin Injection

    MedlinePlus

    ... injection is in a class of medications called penicillins. It works by killing bacteria.Antibiotics such as ... and pharmacist if you are allergic to oxacillin; penicillins; cephalosporin antibiotics such as cefaclor, cefadroxil, cefazolin, cefdinir, ...

  7. Nafcillin Injection

    MedlinePlus

    ... injection is in a class of medications called penicillins. It works by killing bacteria.Antibiotics such as ... and pharmacist if you are allergic to nafcillin; penicillins; cephalosporin antibiotics such as cefaclor, cefadroxil, cefazolin, cefdinir, ...

  8. Ampicillin Injection

    MedlinePlus

    ... injection is in a class of medications called penicillins. It works by killing bacteria.Antibiotics such as ... and pharmacist if you are allergic to ampicillin; penicillins; cephalosporin antibiotics such as cefaclor, cefadroxil, cefazolin (Ancef, ...

  9. Naloxone Injection

    MedlinePlus

    ... emergency medical treatment to reverse the life-threatening effects of a known or suspected opiate (narcotic) overdose. ... is also used after surgery to reverse the effects of opiates given during surgery. Naloxone injection is ...

  10. Omacetaxine Injection

    MedlinePlus

    ... or cannot take these medications due to side effects. Omacetaxine injection is in a class of medications ... a treatment cycle if you experience serious side effects of the medication or if blood tests show ...

  11. Methylnaltrexone Injection

    MedlinePlus

    ... injection is used to treat constipation caused by opioid (narcotic) pain medications in patients with chronic (on-going) pain that is not caused by ... by protecting the bowel from the effects of opioid (narcotic) medications.

  12. Denosumab Injection

    MedlinePlus

    ... menstrual periods), who have an increased risk for fractures (broken bones) or who cannot take or did ... receiving certain treatments that increase their risk for fractures. Denosumab injection (Xgeva) is used to reduce fractures ...

  13. Rasburicase Injection

    MedlinePlus

    ... break down) in people with certain types of cancer who are being treated with chemotherapy medications. Rasburicase injection is in a class of medications called enzymes. It works by breaking down uric acid so that the body can eliminate it.

  14. Gemcitabine Injection

    MedlinePlus

    ... with surgery. Gemcitabine is also used to treat cancer of the pancreas that has spread to other parts of the ... 4 weeks. When gemcitabine is used to treat cancer of pancreas it may be injected once every week. The ...

  15. Granisetron Injection

    MedlinePlus

    ... that may occur after surgery. Granisetron extended-release (long-acting) injection is used with other medications to prevent nausea and vomiting caused by cancer chemotherapy that may occur immediately ...

  16. Fluconazole Injection

    MedlinePlus

    ... injection is used to treat fungal infections, including yeast infections of the mouth, throat, esophagus (tube leading ... by fungus. Fluconazole is also used to prevent yeast infections in patients who are likely to become ...

  17. Docetaxel Injection

    MedlinePlus

    ... allergic to docetaxel injection or drugs made with polysorbate 80, an ingredient found in some medications. Ask ... if a medication you are allergic to contains polysorbate 80. If you experience any of the following ...

  18. Evaluation of the effectiveness of insecticide trunk injections for control of Latoia lepida (Cramer) in the sweet olive tree Osmanthus fragrans.

    PubMed

    Huang, Jun; Zhang, Juan; Li, Yan; Li, Jun; Shi, Xiao-Hua

    2016-01-01

    The screening of suitable insecticides is a key factor in successfully applying trunk injection technology to ornamental plants. In this study, six chemical pesticides were selected and injected into the trunks of Osmanthus fragrans to control the nettle caterpillar, Latoia lepida (Lepidoptera: Limacodidae), using a no-pressure injection system. The absorption rate of the insecticides, the leaf loss due to insect damage, and the mortality and frass amount of L. lepida larvae were evaluated after 77 and 429 days. The results showed that 4% imidacloprid + carbosulfan and 21% abamectin + imidacloprid + omethoate had the fastest conductivity and were completely absorbed into the trunkswithin14 days; however, the efficiencies of these insecticides in controlling L. lepidawere extremely low. Additionally, the treatment 10% emamectin benzoate + clothianidin and 2.5% emamectin benzoate was almost completely absorbed within 30 days and exhibited a longer duration of insecticide efficiency (>80% mortality) in the upper and lower leaves of the canopy. Treatment with these insecticides also resulted in significantly lower leaf loss and frass amounts. We conclude that emamectin benzoate and emamectin benzoate + clothianidin have a rapid uptake into O. fragrans, and are effective as insecticides over long durations. Hence, they may be a suitable control option for L. lepida in O. fragrans plants.

  19. Evaluation of the effectiveness of insecticide trunk injections for control of Latoia lepida (Cramer) in the sweet olive tree Osmanthus fragrans

    PubMed Central

    Li, Yan; Shi, Xiao-Hua

    2016-01-01

    The screening of suitable insecticides is a key factor in successfully applying trunk injection technology to ornamental plants. In this study, six chemical pesticides were selected and injected into the trunks of Osmanthus fragrans to control the nettle caterpillar, Latoia lepida (Lepidoptera: Limacodidae), using a no-pressure injection system. The absorption rate of the insecticides, the leaf loss due to insect damage, and the mortality and frass amount of L. lepida larvae were evaluated after 77 and 429 days. The results showed that 4% imidacloprid + carbosulfan and 21% abamectin + imidacloprid + omethoate had the fastest conductivity and were completely absorbed into the trunkswithin14 days; however, the efficiencies of these insecticides in controlling L. lepidawere extremely low. Additionally, the treatment 10% emamectin benzoate + clothianidin and 2.5% emamectin benzoate was almost completely absorbed within 30 days and exhibited a longer duration of insecticide efficiency (>80% mortality) in the upper and lower leaves of the canopy. Treatment with these insecticides also resulted in significantly lower leaf loss and frass amounts. We conclude that emamectin benzoate and emamectin benzoate + clothianidin have a rapid uptake into O. fragrans, and are effective as insecticides over long durations. Hence, they may be a suitable control option for L. lepida in O. fragrans plants. PMID:27688974

  20. Ultrasound-Guided Versus Fluoroscopy-Guided Caudal Epidural Steroid Injection for the Treatment of Unilateral Lower Lumbar Radicular Pain: Case-Controlled, Retrospective, Comparative Study.

    PubMed

    Park, Ki Deok; Kim, Tai Kon; Lee, Woo Yong; Ahn, JaeKi; Koh, Sung Hoon; Park, Yongbum

    2015-12-01

    The aim of the article is to investigate the efficacy of ultrasound (US)-guided Caudal Epidural Steroid Injection (CESI) compared with fluoroscopy (FL)-guided CESI in patients with unilateral lower lumbar radicular pain. This case-controlled, retrospective, comparative study was done at the university hospital. A total of 110 patients treated with US- or FL-guided CESI were administered a mixture of 20 cc (0.5% lidocaine 18.0  mL + dexamethason 10  mg 2  mL). Outcome measurement was assessed by Oswestry Disability Index (ODI), verbal numeric pain scale (VNS) before injections and at 3, 6, and 12 months after the last injections. Successful outcome was defined as measured by >50% improvement in the VNS score and >40% improvement in the ODI. ODI and VNS showed improvement at 3, 6, and 12 months after the last injection in both groups. No statistical differences in ODI, VNS were observed between groups (P < 0.05). No significant differences in the proportion of patients with successful treatment were observed between the groups from the 3-month to 6-month to 12-month outcomes. US-guided CESI is deserving of consideration in conservative management of unilateral lower lumbar radicular pain.