Sample records for inl experimental program

  1. INL Experimental Program Roadmap for Thermal Hydraulic Code Validation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Glenn McCreery; Hugh McIlroy

    2007-09-01

    Advanced computer modeling and simulation tools and protocols will be heavily relied on for a wide variety of system studies, engineering design activities, and other aspects of the Next Generation Nuclear Power (NGNP) Very High Temperature Reactor (VHTR), the DOE Global Nuclear Energy Partnership (GNEP), and light-water reactors. The goal is for all modeling and simulation tools to be demonstrated accurate and reliable through a formal Verification and Validation (V&V) process, especially where such tools are to be used to establish safety margins and support regulatory compliance, or to design a system in a manner that reduces the role ofmore » expensive mockups and prototypes. Recent literature identifies specific experimental principles that must be followed in order to insure that experimental data meet the standards required for a “benchmark” database. Even for well conducted experiments, missing experimental details, such as geometrical definition, data reduction procedures, and manufacturing tolerances have led to poor Benchmark calculations. The INL has a long and deep history of research in thermal hydraulics, especially in the 1960s through 1980s when many programs such as LOFT and Semiscle were devoted to light-water reactor safety research, the EBRII fast reactor was in operation, and a strong geothermal energy program was established. The past can serve as a partial guide for reinvigorating thermal hydraulic research at the laboratory. However, new research programs need to fully incorporate modern experimental methods such as measurement techniques using the latest instrumentation, computerized data reduction, and scaling methodology. The path forward for establishing experimental research for code model validation will require benchmark experiments conducted in suitable facilities located at the INL. This document describes thermal hydraulic facility requirements and candidate buildings and presents examples of suitable validation experiments related to VHTRs, sodium-cooled fast reactors, and light-water reactors. These experiments range from relatively low-cost benchtop experiments for investigating individual phenomena to large electrically-heated integral facilities for investigating reactor accidents and transients.« less

  2. The Construction of an Embankment with Frozen Soil.

    DTIC Science & Technology

    1980-05-01

    Idewlrty by block numlbe) Inls paper presents the construction procedure, data and analysis from an experimental field program to determine the rippability ...finite element computer solution. Also the frozen chunks, produced in the ripping operation, were analyzed to determine the rippability of the frozen

  3. Laboratory Directed Research and Development FY-15 Annual Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pillai, Rekha Sukamar

    The Laboratory Directed Research and Development (LDRD) Program at Idaho National Laboratory (INL) reports its status to the U.S. Department of Energy (DOE) by March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the laboratory director broad flexibility for program implementation. LDRD funds are obtained through a charge to all INL programs. This report includes summaries of all INL LDRD research activities supported during Fiscal Year (FY) 2015.

  4. 2011 Annual Criticality Safety Program Performance Summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Andrea Hoffman

    The 2011 review of the INL Criticality Safety Program has determined that the program is robust and effective. The review was prepared for, and fulfills Contract Data Requirements List (CDRL) item H.20, 'Annual Criticality Safety Program performance summary that includes the status of assessments, issues, corrective actions, infractions, requirements management, training, and programmatic support.' This performance summary addresses the status of these important elements of the INL Criticality Safety Program. Assessments - Assessments in 2011 were planned and scheduled. The scheduled assessments included a Criticality Safety Program Effectiveness Review, Criticality Control Area Inspections, a Protection of Controlled Unclassified Information Inspection,more » an Assessment of Criticality Safety SQA, and this management assessment of the Criticality Safety Program. All of the assessments were completed with the exception of the 'Effectiveness Review' for SSPSF, which was delayed due to emerging work. Although minor issues were identified in the assessments, no issues or combination of issues indicated that the INL Criticality Safety Program was ineffective. The identification of issues demonstrates the importance of an assessment program to the overall health and effectiveness of the INL Criticality Safety Program. Issues and Corrective Actions - There are relatively few criticality safety related issues in the Laboratory ICAMS system. Most were identified by Criticality Safety Program assessments. No issues indicate ineffectiveness in the INL Criticality Safety Program. All of the issues are being worked and there are no imminent criticality concerns. Infractions - There was one criticality safety related violation in 2011. On January 18, 2011, it was discovered that a fuel plate bundle in the Nuclear Materials Inspection and Storage (NMIS) facility exceeded the fissionable mass limit, resulting in a technical safety requirement (TSR) violation. The TSR limits fuel plate bundles to 1085 grams U-235, which is the maximum loading of an ATR fuel element. The overloaded fuel plate bundle contained 1097 grams U-235 and was assembled under an 1100 gram U-235 limit in 1982. In 2003, the limit was reduced to 1085 grams citing a new criticality safety evaluation for ATR fuel elements. The fuel plate bundle inventories were not checked for compliance prior to implementing the reduced limit. A subsequent review of the NMIS inventory did not identify further violations. Requirements Management - The INL Criticality Safety program is organized and well documented. The source requirements for the INL Criticality Safety Program are from 10 CFR 830.204, DOE Order 420.1B, Chapter III, 'Nuclear Criticality Safety,' ANSI/ANS 8-series Industry Standards, and DOE Standards. These source requirements are documented in LRD-18001, 'INL Criticality Safety Program Requirements Manual.' The majority of the criticality safety source requirements are contained in DOE Order 420.1B because it invokes all of the ANSI/ANS 8-Series Standards. DOE Order 420.1B also invokes several DOE Standards, including DOE-STD-3007, 'Guidelines for Preparing Criticality Safety Evaluations at Department of Energy Non-Reactor Nuclear Facilities.' DOE Order 420.1B contains requirements for DOE 'Heads of Field Elements' to approve the criticality safety program and specific elements of the program, namely, the qualification of criticality staff and the method for preparing criticality safety evaluations. This was accomplished by the approval of SAR-400, 'INL Standardized Nuclear Safety Basis Manual,' Chapter 6, 'Prevention of Inadvertent Criticality.' Chapter 6 of SAR-400 contains sufficient detail and/or reference to the specific DOE and contractor documents that adequately describe the INL Criticality Safety Program per the elements specified in DOE Order 420.1B. The Safety Evaluation Report for SAR-400 specifically recognizes that the approval of SAR-400 approves the INL Criticality Safety Program. No new source requirements were released in 2011. A revision to LRD-18001 is planned for 2012 to clarify design requirements for criticality alarms. Training - Criticality Safety Engineering has developed training and provides training for many employee positions, including fissionable material handlers, facility managers, criticality safety officers, firefighters, and criticality safety engineers. Criticality safety training at the INL is a program strength. A revision to the training module developed in 2010 to supplement MFC certified fissionable material handlers (operators) training was prepared and presented in August of 2011. This training, 'Applied Science of Criticality Safety,' builds upon existing training and gives operators a better understanding of how their criticality controls are derived. Improvements to 00INL189, 'INL Criticality Safety Principles' are planned for 2012 to strengthen fissionable material handler training.« less

  5. Idaho National Laboratory Site Pollution Prevention Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    E. D. Sellers

    2007-03-01

    It is the policy of the Department of Energy (DOE) that pollution prevention and sustainable environmental stewardship will be integrated into DOE operations as a good business practice to reduce environmental hazards, protect environmental resources, avoid pollution control costs, and improve operational efficiency and mission sustainability. In furtherance of this policy, DOE established five strategic, performance-based Pollution Prevention (P2) and Sustainable Environmental Stewardship goals and included them as an attachment to DOE O 450.1, Environmental Protection Program. These goals and accompanying strategies are to be implemented by DOE sites through the integration of Pollution Prevention into each site's Environmental Managementmore » System (EMS). This document presents a P2 and Sustainability Program and corresponding plan pursuant to DOE Order 450.1 and DOE O 435.1, Radioactive Waste Management. This plan is also required by the state of Idaho, pursuant to the Resource Conservation and Recovery Act (RCRA) partial permit. The objective of this document is to describe the Idaho National Laboratory (INL) Site P2 and Sustainability Program. The purpose of the program is to decrease the environmental footprint of the INL Site while providing enhanced support of its mission. The success of the program is dependent on financial and management support. The signatures on the previous page indicate INL, ICP, and AMWTP Contractor management support and dedication to the program. P2 requirements have been integrated into working procedures to ensure an effective EMS as part of an Integrated Safety Management System (ISMS). This plan focuses on programmatic functions which include environmentally preferable procurement, sustainable design, P2 and Sustainability awareness, waste generation and reduction, source reduction and recycling, energy management, and pollution prevention opportunity assessments. The INL Site P2 and Sustainability Program is administratively managed by the INL Site P2 Coordinator. Development and maintenance of this overall INL Site plan is ultimately the responsibility of DOE-ID. This plan is applicable to all INL Site contractors except those at the Naval Reactors Facility.« less

  6. Laboratory-Directed Research and Development 2016 Summary Annual Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pillai, Rekha Sukamar; Jacobson, Julie Ann

    The Laboratory-Directed Research and Development (LDRD) Program at Idaho National Laboratory (INL) reports its status to the U.S. Department of Energy (DOE) by March of each year. The program operates under the authority of DOE Order 413.2C, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the laboratory director broad flexibility for program implementation. LDRD funds are obtained through a charge to all INL programs. This report includes summaries of all INL LDRD research activities supported during Fiscal Year (FY) 2016. INL is the lead laboratory for the DOE Office of Nuclearmore » Energy (DOE-NE). The INL mission is to discover, demonstrate, and secure innovative nuclear energy solutions, other clean energy options, and critical infrastructure with a vision to change the world’s energy future and secure our critical infrastructure. Operating since 1949, INL is the nation’s leading research, development, and demonstration center for nuclear energy, including nuclear nonproliferation and physical and cyber-based protection of energy systems and critical infrastructure, as well as integrated energy systems research, development, demonstration, and deployment. INL has been managed and operated by Battelle Energy Alliance, LLC (a wholly owned company of Battelle) for DOE since 2005. Battelle Energy Alliance, LLC, is a partnership between Battelle, BWX Technologies, Inc., AECOM, the Electric Power Research Institute, the National University Consortium (Massachusetts Institute of Technology, Ohio State University, North Carolina State University, University of New Mexico, and Oregon State University), and the Idaho university collaborators (i.e., University of Idaho, Idaho State University, and Boise State University). Since its creation, INL’s research and development (R&D) portfolio has broadened with targeted programs supporting national missions to advance nuclear energy, enable clean energy deployment, and secure and modernize critical infrastructure. INL’s research, development, and demonstration capabilities, its resources, and its unique geography enable integration of scientific discovery, innovation, engineering, operations, and controls into complex large-scale testbeds for discovery, innovation, and demonstration of transformational clean energy and security concepts. These attributes strengthen INL’s leadership as a demonstration laboratory. As a national resource, INL also applies its capabilities and skills to the specific needs of other federal agencies and customers through DOE’s Strategic Partnership Program.« less

  7. Data Quality Objectives Supporting the Environmental Soil Monitoring Program for the Idaho National Laboratory Site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haney, Thomas Jay

    This document describes the process used to develop data quality objectives for the Idaho National Laboratory (INL) Environmental Soil Monitoring Program in accordance with U.S. Environmental Protection Agency guidance. This document also develops and presents the logic that was used to determine the specific number of soil monitoring locations at the INL Site, at locations bordering the INL Site, and at locations in the surrounding regional area. The monitoring location logic follows the guidance from the U.S. Department of Energy for environmental surveillance of its facilities.

  8. The influence of precipitation, vegetation and soil properties on the ecohydrology of sagebrush steppe rangelands on the INL site

    USGS Publications Warehouse

    Germino, Matthew J.

    2013-01-01

    The INL Site and other landscapes having sagebrush steppe vegetation are experiencing a simultaneous change in climate and floristics that result from increases in exotic species. Determining the separate and combined/interactive effects of climate and vegetation change is important for assessing future changes on the landscape and for hydrologic processes. This research uses the 72 experimental plots established and initially maintained for many years as the “Protective Cap Biobarrier Experiment” by Dr. Jay Anderson and the Stoller ESER program, and the experiment is also now referred to as the “INL Site Ecohydrology Study.” We are evaluating long-term impacts of different plant communities commonly found throughout Idaho subject to different precipitation regimes and to different soil depths. Treatments of amount and timing of precipitation (irrigation), soil depth, and either native/perennial or exotic grass vegetation allow researchers to investigate how vegetation, precipitation and soil interact to influence soil hydrology and ecosystem biogeochemistry. This information will be used to improve a variety of models, as well as provide data for these models.

  9. TESTING AND PERFORMANCE ANALYSIS OF NASA 5 CM BY 5 CM BI-SUPPORTED SOLID OXIDE ELECTROLYSIS CELLS OPERATED IN BOTH FUEL CELL AND STEAM ELECTROLYSIS MODES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    R. C. O'Brien; J. E. O'Brien; C. M. Stoots

    A series of 5 cm by 5 cm bi-supported Solid Oxide Electrolysis Cells (SOEC) were produced by NASA for the Idaho National Laboratory (INL) and tested under the INL High Temperature Steam Electrolysis program. The results from the experimental demonstration of cell operation for both hydrogen production and operation as fuel cells is presented. An overview of the cell technology, test apparatus and performance analysis is also provided. The INL High Temperature Steam Electrolysis laboratory has developed significant test infrastructure in support of single cell and stack performance analyses. An overview of the single cell test apparatus is presented. Themore » test data presented in this paper is representative of a first batch of NASA's prototypic 5 cm by 5 cm SOEC single cells. Clearly a significant relationship between the operational current density and cell degradation rate is evident. While the performance of these cells was lower than anticipated, in-house testing at NASA Glenn has yielded significantly higher performance and lower degradation rates with subsequent production batches of cells. Current post-test microstructure analyses of the cells tested at INL will be published in a future paper. Modification to cell compositions and cell reduction techniques will be altered in the next series of cells to be delivered to INL with the aim to decrease the cell degradation rate while allowing for higher operational current densities to be sustained. Results from the testing of new batches of single cells will be presented in a future paper.« less

  10. INL Generic Robot Architecture

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    2005-03-30

    The INL Generic Robot Architecture is a generic, extensible software framework that can be applied across a variety of different robot geometries, sensor suites and low-level proprietary control application programming interfaces (e.g. mobility, aria, aware, player, etc.).

  11. WIPP Waste Information Systems (WWIS)

    EPA Pesticide Factsheets

    EPA approved the INL-CCP and ANL-CCP RH TRU WC programs based on a demonstration of the sites’ capabilities, with conditions and limitations as documented in the INL Baseline Final Inspection Report and the ANL Baseline Final Inspection Report.

  12. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haney, Thomas Jay

    This report documents the Data Quality Objectives (DQOs) developed for the Idaho National Laboratory (INL) Site ambient air surveillance program. The development of the DQOs was based on the seven-step process recommended “for systematic planning to generate performance and acceptance criteria for collecting environmental data” (EPA 2006). The process helped to determine the type, quantity, and quality of data needed to meet current regulatory requirements and to follow U.S. Department of Energy guidance for environmental surveillance air monitoring design. It also considered the current air monitoring program that has existed at INL Site since the 1950s. The development of themore » DQOs involved the application of the atmospheric dispersion model CALPUFF to identify likely contamination dispersion patterns at and around the INL Site using site-specific meteorological data. Model simulations were used to quantitatively assess the probable frequency of detection of airborne radionuclides released by INL Site facilities using existing and proposed air monitors.« less

  13. Process for selecting NEAMS applications for access to Idaho National Laboratory high performance computing resources

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Michael Pernice

    2010-09-01

    INL has agreed to provide participants in the Nuclear Energy Advanced Mod- eling and Simulation (NEAMS) program with access to its high performance computing (HPC) resources under sponsorship of the Enabling Computational Technologies (ECT) program element. This report documents the process used to select applications and the software stack in place at INL.

  14. Idaho National Laboratory Directed Research and Development FY-2009

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2010-03-01

    The FY 2009 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support the future DOE missions and national research priorities. LDRD is essential to the INL - it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enhances technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development. Established by Congress in 1991, LDRD proves its benefitmore » each year through new programs, intellectual property, patents, copyrights, publications, national and international awards, and new hires from the universities and industry, which helps refresh the scientific and engineering workforce. The benefits of INL's LDRD research are many as shown in the tables below. Last year, 91 faculty members from various universities contributed to LDRD research, along with 7 post docs and 64 students. Of the total invention disclosures submitted in FY 2009, 7 are attributable to LDRD research. Sixty three refereed journal articles were accepted or published, and 93 invited presentations were attributable to LDRD research conducted in FY 2009. The LDRD Program is administered in accordance with requirements set in DOE Order 413.2B, accompanying contractor requirements, and other DOE and federal requirements invoked through the INL contract. The LDRD Program is implemented in accordance with the annual INL LDRD Program Plan, which is approved by the DOE, Nuclear Energy Program Secretarial Office. This plan outlines the method the laboratory uses to develop its research portfolio, including peer and management reviews, and the use of other INL management systems to ensure quality, financial, safety, security and environmental requirements and risks are appropriately handled. The LDRD Program is assessed annually for both output and process efficiency to ensure the investment is providing expected returns on technical capability enhancement. The call for proposals and project selection process for the INL LDRD program begins typically in April, with preliminary budget allocations, and submittal of the technical requests for preproposals. A call for preproposals is made at this time as well, and the preparation of full proposals follows in June and closes in July. The technical and management review follows this, and the portfolio is submitted for DOE-ID concurrence in early September. Project initiation is in early October. The technical review process is independent of, and in addition to the management review. These review processes are very stringent and comprehensive, ensuring technical viability and suitable technical risk are encompassed within each project that is selected for funding. Each proposal is reviewed by two or three anonymous technical peers, and the reviews are consolidated into a cohesive commentary of the overall research based on criteria published in the call for proposals. A grade is assigned to the technical review and the review comments and grade are released back to the principal investigators and the managers interested in funding the proposals. Management criteria are published in the call for proposals, and management comments and selection results are available for principal investigator and other interested management as appropriate. The DOE Idaho Operations Office performs a final review and concurs on each project prior to project authorization, and on major scope/budget changes should they occur during the project's implementation. This report begins with several research highlights that exemplify the diversity of scientific and engineering research performed at the INL in FY 2009. Progress summaries for all projects are organized into sections reflecting the major areas of research focus at the INL. These sections begin with the DOE-NE Nuclear Science and Technology mission support area, followed by the National and Homeland Security and the Energy and Environmental Science and Technology areas. The major INL initiatives and the INL's Distinctive Signatures areas complete the project summaries. The appendices provide information on project relevance to DOE missions and major national programs as well as an author index, list of refereed publications and index of key terms.« less

  15. Idaho National Laboratory Human Capitol Development Program Summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rynes, Amanda R.

    2014-09-01

    The Next Generation Safeguards Initiative HCD Subprogram has successfully employed unique nuclear capabilities and employee expertise through INL to achieve multiple initiatives in FY14. These opportunities range from internship programs to university and training courses. One of the central facets of this work has been the international safeguards pre inspector training course. Another significant milestone is the INL led university engagement effort which resulted in courses being offered at ISU and University of Utah.

  16. Of mice and men: Dissecting the interaction between Listeria monocytogenes Internalin A and E-cadherin

    PubMed Central

    Genheden, Samuel; Eriksson, Leif A

    2013-01-01

    We report a study of the interaction between internalin A (inlA) and human or murine E-cadherin (Ecad). inlA is used by Listeria monocytogenes to internalize itself into host cell, but the bacterium is unable to invade murine cells, which has been attributed to the difference in sequence between hEcad and mEcad. Using molecular dynamics simulations, MM/GBSA free energy calculations, hydrogen bond analysis, water characterization and umbrella sampling, we provide a complete atomistic picture of the binding between inlA and Ecad. We dissect key residues in the protein–protein interface and analyze the energetics using MM/GBSA. From this analysis it is clear that the binding of inlA–mEcad is weaker than inlA–hEcad, on par with the experimentally observed inability of inlA to bind to mEcad. However, extended MD simulations of 200 ns in length show no destabilization of the inlA–mEcad complex and the estimation of the potential of mean force (PMF) using umbrella sampling corroborates this conclusion. The binding strength computed from the PMFs show no significant difference between the two protein complexes. Hence, our study suggests that the inability of L. monocytogenes to invade murine cells cannot be explained by processes at the nanosecond to sub-microsecond time scale probed by the simulations performed here. PMID:24688730

  17. Of mice and men: Dissecting the interaction between Listeria monocytogenes Internalin A and E-cadherin.

    PubMed

    Genheden, Samuel; Eriksson, Leif A

    2013-01-01

    We report a study of the interaction between internalin A (inlA) and human or murine E-cadherin (Ecad). inlA is used by Listeria monocytogenes to internalize itself into host cell, but the bacterium is unable to invade murine cells, which has been attributed to the difference in sequence between hEcad and mEcad. Using molecular dynamics simulations, MM/GBSA free energy calculations, hydrogen bond analysis, water characterization and umbrella sampling, we provide a complete atomistic picture of the binding between inlA and Ecad. We dissect key residues in the protein-protein interface and analyze the energetics using MM/GBSA. From this analysis it is clear that the binding of inlA-mEcad is weaker than inlA-hEcad, on par with the experimentally observed inability of inlA to bind to mEcad. However, extended MD simulations of 200 ns in length show no destabilization of the inlA-mEcad complex and the estimation of the potential of mean force (PMF) using umbrella sampling corroborates this conclusion. The binding strength computed from the PMFs show no significant difference between the two protein complexes. Hence, our study suggests that the inability of L. monocytogenes to invade murine cells cannot be explained by processes at the nanosecond to sub-microsecond time scale probed by the simulations performed here.

  18. Energy Systems Laboratory Groundbreaking

    ScienceCinema

    Hill, David; Otter, C.L.; Simpson, Mike; Rogers, J.W.

    2018-05-11

    INL recently broke ground for a research facility that will house research programs for bioenergy, advanced battery systems, and new hybrid energy systems that integrate renewable, fossil and nuclear energy sources. Here's video from the groundbreaking ceremony for INL's new Energy Systems Laboratory. You can learn more about CAES research at http://www.facebook.com/idahonationallaboratory.

  19. Idaho National Laboratory Emergency Readiness Assurance Plan — Fiscal Year 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    Battelle Energy Alliance, LLC, the prime contractor for Idaho National Laboratory (INL), provides this Emergency Readiness Assurance Plan (ERAP) for Fiscal Year 2016 in accordance with DOE O 151.1C, “Comprehensive Emergency Management System.” The ERAP documents the readiness of the INL Emergency Management Program using emergency response planning and preparedness activities as the basis. It describes emergency response planning and preparedness activities, and where applicable, summarizes and/or provides supporting information in tabular form for easy access to data. The ERAP also provides budget, personnel, and planning forecasts for Fiscal Year 2017. Specifically, the ERAP assures the Department of Energy Idahomore » Operations Office that stated emergency capabilities at INL are sufficient to implement PLN 114, “INL Emergency Plan/RCRA Contingency Plan.”« less

  20. Idaho National Laboratory Emergency Readiness Assurance Plan — Fiscal Year 2014

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bush, Shane

    Battelle Energy Alliance, LLC, the prime contractor for Idaho National Laboratory (INL), provides this Emergency Readiness Assurance Plan (ERAP) for Fiscal Year 2014 in accordance with DOE O 151.1C, “Comprehensive Emergency Management System.” The ERAP documents the readiness of the INL Emergency Management Program using emergency response planning and preparedness activities as the basis. It describes emergency response planning and preparedness activities, and where applicable, summarizes and/or provides supporting information in tabular form for easy access to data. The ERAP also provides budget, personnel, and planning forecasts for Fiscal Year 2015. Specifically, the ERAP assures the Department of Energy Idahomore » Operations Office that stated emergency capabilities at INL are sufficient to implement PLN-114, “INL Emergency Plan/RCRA Contingency Plan.”« less

  1. Testing large volume water treatment and crude oil ...

    EPA Pesticide Factsheets

    Report EPA’s Homeland Security Research Program (HSRP) partnered with the Idaho National Laboratory (INL) to build the Water Security Test Bed (WSTB) at the INL test site outside of Idaho Falls, Idaho. The WSTB was built using an 8-inch (20 cm) diameter cement-mortar lined drinking water pipe that was previously taken out of service. The pipe was exhumed from the INL grounds and oriented in the shape of a small drinking water distribution system. Effluent from the pipe is captured in a lagoon. The WSTB can support drinking water distribution system research on a variety of drinking water treatment topics including biofilms, water quality, sensors, and homeland security related contaminants. Because the WSTB is constructed of real drinking water distribution system pipes, research can be conducted under conditions similar to those in a real drinking water system. In 2014, WSTB pipe was experimentally contaminated with Bacillus globigii spores, a non-pathogenic surrogate for the pathogenic B. anthracis, and then decontaminated using chlorine dioxide. In 2015, the WSTB was used to perform the following experiments: • Four mobile disinfection technologies were tested for their ability to disinfect large volumes of biologically contaminated “dirty” water from the WSTB. B. globigii spores acted as the biological contaminant. The four technologies evaluated included: (1) Hayward Saline C™ 6.0 Chlorination System, (2) Advanced Oxidation Process (A

  2. Development and Test Evaluations for Ni-DOBDC Metal Organic Framework (MOF) Engineered Forms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Troy G. Garn; Mitchell Greenhalgh

    2013-07-01

    A joint effort to prepare engineered forms of a Ni-DOBDC metal organic framework (MOF) was completed with contributions from PNNL, SNL and the INL. Two independent methods were used at INL and SNL to prepare engineered form (EF) sorbents from Ni-DOBDC MOF powder developed and prepared at PNNL. Xe and Kr capacity test evaluations were performed at ambient temperature with the cryostat experimental setup at INL. The initial INL EF MOF test results indicated a Xe capacity of 1.6 mmol/kg sorbent and no Kr capacity. A large loss of surface area also occurred during minimal testing rendering the INL EFmore » MOF unusable. Four capacity tests were completed using the SNL EF MOF at ambient temperature and resulted in Xe capacities of 1.4, 4.2, 5.0 and 3.8 mmol/kg sorbent with no Kr capacity observed in any ambient temperature tests. Two additional capacity tests were performed at 240 K to further evaluate SNL EF MOF performance. Xe capacities of 50.7 and 49.3 mmol/kg of sorbent and Kr capacities of 0.77 and 0.69 mmol/kg of sorbent were obtained, respectively. Following the adsorption evaluations, the SNL EF MOF material had lost about 40 % of the initial mass and 40 % of the initial surface area. In general, the Xe capacity results at ambient temperature for the INL and SNL EF Ni-DOBDC MOF’s were lower than 9.8 mmol Xe/kg sorbent test results reported by INL in FY-12 using PNNL’s inital EF supplied material.« less

  3. Progress Toward Security and Stability in Afghanistan. Report to Congress in accordance with the 2008 National Defense Authorization Act (Section 1230, Public Law 110-181)

    DTIC Science & Technology

    2009-06-01

    sub-national government. INL, through its Justice Sector Support Program ( JSSP ), is strengthening the capacity of the Attorney General’s Office to...monitor, investigate, prosecute and appeal cases of corruption more efficiently, effectively, and fairly. To this end, INL/ JSSP , with support from

  4. Idaho National Laboratory Cultural Resource Management Office FY 2010 Activity Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hollie K. Gilbert; Clayton F. Marler; Christina L. Olson

    2011-09-01

    The Idaho National Laboratory (INL) Site is home to vast numbers and a wide variety of important cultural resources representing at least a 13,500 year span of human land use in the region. As a federal agency, the Department of Energy, Idaho Operations Office (DOE-ID) has legal responsibility for the management and protection of the resources and has contracted these responsibilities to Battelle Energy Alliance (BEA). The BEA professional staff is committed to maintaining a cultural resource management program that accepts the challenge of preserving INL cultural resources in a manner reflecting their importance in local, regional, and national history.more » This report summarizes activities performed by the INL Cultural Resource Management Office (CRMO) staff during fiscal year 2010. This work is diverse, far-reaching and though generally confined to INL cultural resource compliance, also includes a myriad of professional and voluntary community activities. This document is intended to be informative to both internal and external stakeholders and to serve as a planning tool for future INL cultural resource management work.« less

  5. U.S. Geological Survey geohydrologic studies and monitoring at the Idaho National Laboratory, southeastern Idaho

    USGS Publications Warehouse

    Bartholomay, Roy C.

    2017-09-14

    BackgroundThe U.S. Geological Survey (USGS) geohydrologic studies and monitoring at the Idaho National Laboratory (INL) is an ongoing, long-term program. This program, which began in 1949, includes hydrologic monitoring networks and investigative studies that describe the effects of waste disposal on water contained in the eastern Snake River Plain (ESRP) aquifer and the availability of water for long-term consumptive and industrial use. Interpretive reports documenting study findings are available to the U.S. Department of Energy (DOE) and its contractors; other Federal, State, and local agencies; private firms; and the public at https://id.water.usgs.gov/INL/Pubs/index.html. Information contained within these reports is crucial to the management and use of the aquifer by the INL and the State of Idaho. USGS geohydrologic studies and monitoring are done in cooperation with the DOE Idaho Operations Office.

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barnes, Scott V.

    On August 1, 2014, Idaho National Laboratory (INL), in coordination with the State of Idaho, local jurisdictions, Department of Energy (DOE) Idaho Operations Office, and DOE Headquarters (DOE-HQ), conducted the annual emergency exercise to demonstrate the ability to implement the requirements of DOE O 151.1C, “Comprehensive Emergency Management System.” The INL contractor, Battelle Energy Alliance, LLC (BEA), in coordination with other INL contractors, conducted operations and demonstrated appropriate response measures to mitigate an event and protect the health and safety of personnel, the environment, and property. Offsite response organizations participated to demonstrate appropriate response measures. Report data were collected frommore » multiple sources, which included documentation generated during exercise response, player critiques conducted immediately after terminating the exercise, personnel observation sheets, and evaluation critiques. Evaluation of this exercise served as a management assessment of the performance of the INL Emergency Management Program (IAS141618).« less

  7. Supercritical/Solid Catalyst (SSC)

    ScienceCinema

    Ginosar, Daniel; Fox, Robert; Bright, Patricia

    2018-05-23

    INL's patented, continuous-flow Supercritical/Solid Catalyst (SSC) produces the highest ASTM-quality B-100 biodiesel from waste fats, oils, and greases at the site of waste generation. SSC delivers low-cost transportation fuel, avoids significant landfill costs for municipalities, and reduces potent methane and other emissions produced in landfills from these wastes. You can learn more about INL's energy research programs at http://www.facebook.com/idahonationallaboratory.

  8. Supercritical/Solid Catalyst (SSC)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ginosar, Daniel; Fox, Robert; Bright, Patricia

    2010-05-28

    INL's patented, continuous-flow Supercritical/Solid Catalyst (SSC) produces the highest ASTM-quality B-100 biodiesel from waste fats, oils, and greases at the site of waste generation. SSC delivers low-cost transportation fuel, avoids significant landfill costs for municipalities, and reduces potent methane and other emissions produced in landfills from these wastes. You can learn more about INL's energy research programs at http://www.facebook.com/idahonationallaboratory.

  9. Cyber Security Testing and Training Programs for Industrial Control Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daniel Noyes

    2012-03-01

    Service providers rely on industrial control systems (ICS) to manage the flow of water at dams, open breakers on power grids, control ventilation and cooling in nuclear power plants, and more. In today's interconnected environment, this can present a serious cyber security challenge. To combat this growing challenge, government, private industry, and academia are working together to reduce cyber risks. The Idaho National Laboratory (INL) is a key contributor to the Department of Energy National SCADA Test Bed (NSTB) and the Department of Homeland Security (DHS) Control Systems Security Program (CSSP), both of which focus on improving the overall securitymore » posture of ICS in the national critical infrastructure. In support of the NSTB, INL hosts a dedicated SCADA testing facility which consists of multiple control systems supplied by leading national and international manufacturers. Within the test bed, INL researchers systematically examine control system components and work to identify vulnerabilities. In support of the CSSP, INL develops and conducts training courses which are designed to increase awareness and defensive capabilities for IT/Control System professionals. These trainings vary from web-based cyber security trainings for control systems engineers to more advanced hands-on training that culminates with a Red Team/ Blue Team exercise that is conducted within an actual control systems environment. INL also provides staffing and operational support to the DHS Industrial Control Systems Cyber Emergency Response Team (ICS-CERT) Security Operations Center which responds to and analyzes control systems cyber incidents across the 18 US critical infrastructure sectors.« less

  10. Idaho National Laboratory Cultural Resource Management Office FY 2011 Activity Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Julie Braun Williams; Brenda R. Pace; Hollie K. Gilbert

    The Idaho National Laboratory (INL) Site is home to vast numbers and a wide variety of important cultural resources representing at least a 13,500 year span of human land use in the region. As a federal agency, the Department of Energy, Idaho Operations Office (DOE-ID) has legal responsibility for the management and protection of the resources and has contracted these responsibilities to Battelle Energy Alliance (BEA). The BEA professional staff is committed to maintaining a cultural resource management program that accepts the challenge of preserving INL cultural resources in a manner reflecting their importance in local, regional, and national history.more » This report is intended as a stand-alone document that summarizes activities performed by the INL Cultural Resource Management Office (CRMO) staff during fiscal year 2011. This work is diverse, far-reaching and though generally confined to INL cultural resource compliance, also includes a myriad of professional and voluntary community activities. This document is intended to be informative to both internal and external stakeholders, serve as a planning tool for future INL cultural resource management work, and meet an agreed upon legal requirement.« less

  11. Operational Philosophy for the Advanced Test Reactor National Scientific User Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J. Benson; J. Cole; J. Jackson

    2013-02-01

    In 2007, the Department of Energy (DOE) designated the Advanced Test Reactor (ATR) as a National Scientific User Facility (NSUF). At its core, the ATR NSUF Program combines access to a portion of the available ATR radiation capability, the associated required examination and analysis facilities at the Idaho National Laboratory (INL), and INL staff expertise with novel ideas provided by external contributors (universities, laboratories, and industry). These collaborations define the cutting edge of nuclear technology research in high-temperature and radiation environments, contribute to improved industry performance of current and future light-water reactors (LWRs), and stimulate cooperative research between user groupsmore » conducting basic and applied research. To make possible the broadest access to key national capability, the ATR NSUF formed a partnership program that also makes available access to critical facilities outside of the INL. Finally, the ATR NSUF has established a sample library that allows access to pre-irradiated samples as needed by national research teams.« less

  12. Technology Transfer Annual Report Fiscal Year 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Skinner, Wendy Lee

    Idaho National Laboratory (INL) is a Department of Energy (DOE) multi-program national laboratory that conducts research and development in all DOE mission areas. Like all other federal laboratories, INL has a statutory, technology transfer mission to make its capabilities and technologies available to federal agencies, state and local governments, universities, and industry. To fulfill this mission, INL encourages its scientific, engineering, and technical staff to disclose new inventions and creations to ensure the resulting intellectual property is captured, protected, and available to others who might benefit from it. As part of the mission, intellectual property is licensed to industrial partnersmore » for commercialization, job creation, and delivering the benefits of federally funded technology to consumers. In some cases, unique capabilities are made available to other federal agencies, international organizations, domestic and foreign commercial entities, or small businesses to solve specific technical challenges. INL employees work cooperatively with researchers and technical staff from the university and industrial sectors to further development of emerging technologies. In this multinational global economy, INL is contributing to the development of the next generation of engineers and scientists by licensing software to educational institutions throughout the world. This report is a catalog of select INL technology transfer and commercialization transactions and research agreements that were executed during this past year. The size and diversity of INL technical resources, coupled with the large number of relationships with other organizations, virtually ensures that a report of this nature will fail to capture all interactions. Recognizing this limitation, this report focuses on transactions that are specifically authorized by technology transfer legislation (and corresponding contractual provisions) or involve the transfer of legal rights to technology to other parties. This report was compiled from primary records, which were readily available to the INL’s Technology Deployment and Contracts Management Offices. Accomplishments cataloged in the report reflect the achievements and creativity of the researchers, technicians, support staff, and operators of the INL workforce.« less

  13. DOE Office of Scientific and Technical Information (OSTI.GOV)

    N /A

    Idaho National Laboratory (INL) is a Department of Energy (DOE) multi-program national laboratory that conducts research and development in all DOE mission areas. Like all other federal laboratories, INL has a statutory technology transfer mission to make its capabilities and technologies available to all federal agencies, to state and local governments, and to universities and industry. To fulfill this mission, INL encourages its scientific, engineering, and technical staff to disclose new inventions and creations to ensure the resulting intellectual property is captured, protected, and made available to others who might benefit from it. As part of the mission, intellectual propertymore » is licensed to industrial partners for commercialization, creating jobs and delivering the benefits of federally funded technology to consumers. In other cases, unique capabilities are made available to other federal agencies or to regional small businesses to solve specific technical challenges. INL employees also work cooperatively with researchers and technical staff from the university and industrial sectors to further develop emerging technologies. In a multinational global economy, INL is contributing to the development of the next generation of engineers and scientists by licensing software to educational institutions throughout the world. This report is a catalog of selected INL technology transfer and commercialization transactions during this past year. The size and diversity of INL technical resources, coupled with the large number of relationships with other organizations, virtually ensures that a report of this nature will fail to capture all interactions. Recognizing this limitation, this report focuses on transactions that are specifically authorized by technology transfer legislation (and corresponding contractual provisions) or involve the transfer of legal rights to technology to other parties. This report was compiled from primary records, which were readily available to the INL’s Office of Technology Deployment. However, the accomplishments cataloged in the report reflect the achievements and creativity of the researchers, technicians, support staff, and operators of the INL workforce.« less

  14. Molecular and phenotypic characterization of Listeria monocytogenes from U.S. Department of Agriculture Food Safety and Inspection Service surveillance of ready-to-eat foods and processing facilities.

    PubMed

    Ward, Todd J; Evans, Peter; Wiedmann, Martin; Usgaard, Thomas; Roof, Sherry E; Stroika, Steven G; Hise, Kelley

    2010-05-01

    A panel of 501 Listeria monocytogenes isolates obtained from the U.S. Department of Agriculture Food Safety and Inspection Service monitoring programs for ready-to-eat (RTE) foods were subtyped by multilocus genotyping (MLGT) and by sequencing the virulence gene inlA, which codes for internalin. MLGT analyses confirmed that clonal lineages associated with previous epidemic outbreaks were rare (7.6%) contaminants of RTE meat and poultry products and their production environments. Conversely, sequence analyses revealed mutations leading to 11 different premature stop codons (PMSCs) in inlA, including three novel PMSC mutations, and revealed that the frequency of these virulence-attenuating mutations among RTE isolates (48.5%) was substantially higher than previously appreciated. Significant differences (P < 0.001) in the frequency of inlA PMSCs were observed between lineages and between major serogroups, which could partially explain differences in association of these subtypes with human listeriosis. Interrogation of single-nucleotide polymorphisms responsible for PMSCs in inlA improved strain resolution among isolates with the 10 most common pulsed-field gel electrophoresis (PFGE) patterns, 8 of which included isolates with a PMSC in inlA. The presence or absence of PMSCs in inlA accounted for significant differences (P < 0.05) in Caco-2 invasion efficiencies among isolates with identical PFGE patterns, and the proportion of PulseNet entries from clinical sources was significantly higher (P < 0.001) for PFGE patterns exclusively from isolates with full-length inlA. These results indicated that integration of PFGE and DNA sequence-based subtyping provides an improved framework for prediction of relative risk associated with L. monocytogenes strains from RTE foods.

  15. Development plan for the External Hazards Experimental Group. Light Water Reactor Sustainability Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Coleman, Justin Leigh; Smith, Curtis Lee; Burns, Douglas Edward

    This report describes the development plan for a new multi-partner External Hazards Experimental Group (EHEG) coordinated by Idaho National Laboratory (INL) within the Risk-Informed Safety Margin Characterization (RISMC) technical pathway of the Light Water Reactor Sustainability Program. Currently, there is limited data available for development and validation of the tools and methods being developed in the RISMC Toolkit. The EHEG is being developed to obtain high-quality, small- and large-scale experimental data validation of RISMC tools and methods in a timely and cost-effective way. The group of universities and national laboratories that will eventually form the EHEG (which is ultimately expectedmore » to include both the initial participants and other universities and national laboratories that have been identified) have the expertise and experimental capabilities needed to both obtain and compile existing data archives and perform additional seismic and flooding experiments. The data developed by EHEG will be stored in databases for use within RISMC. These databases will be used to validate the advanced external hazard tools and methods.« less

  16. AGR-1 Compact 1-3-1 Post-Irradiation Examination Results

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Demkowicz, Paul Andrew

    The Advanced Gas Reactor (AGR) Fuel Development and Qualification Program was established to perform the requisite research and development on tristructural isotropic (TRISO) coated particle fuel to support deployment of a high-temperature gas-cooled reactor (HTGR). The work continues as part of the Advanced Reactor Technologies (ART) TRISO Fuel program. The overarching program goal is to provide a baseline fuel qualification data set to support licensing and operation of an HTGR. To achieve these goals, the program includes the elements of fuel fabrication, irradiation, post-irradiation examination (PIE) and safety testing, fuel performance modeling, and fission product transport (INL 2015). A seriesmore » of fuel irradiation experiments is being planned and conducted in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL). These experiments will provide data on fuel performance under irradiation, support fuel process development, qualify the fuel for normal operating conditions, provide irradiated fuel for safety testing, and support the development of fuel performance and fission product transport models. The first of these irradiation tests, designated AGR-1, began in the ATR in December 2006 and ended in November 2009. This experiment was conducted primarily to act as a shakedown test of the multicapsule test train design and provide early data on fuel performance for use in fuel fabrication process development. It also provided samples for post-irradiation safety testing, where fission product retention of the fuel at high temperatures will be experimentally measured. The capsule design and details of the AGR-1 experiment have been presented previously (Grover, Petti, and Maki 2010, Maki 2009).« less

  17. AGR-1 Compact 5-3-1 Post-Irradiation Examination Results

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Demkowicz, Paul; Harp, Jason; Winston, Phil

    The Advanced Gas Reactor (AGR) Fuel Development and Qualification Program was established to perform the requisite research and development on tristructural isotropic (TRISO) coated particle fuel to support deployment of a high-temperature gas-cooled reactor (HTGR). The work continues as part of the Advanced Reactor Technologies (ART) TRISO Fuel program. The overarching program goal is to provide a baseline fuel qualification data set to support licensing and operation of an HTGR. To achieve these goals, the program includes the elements of fuel fabrication, irradiation, post-irradiation examination (PIE) and safety testing, fuel performance, and fission product transport (INL 2015). A series ofmore » fuel irradiation experiments is being planned and conducted in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL). These experiments will provide data on fuel performance under irradiation, support fuel process development, qualify the fuel for normal operating conditions, provide irradiated fuel for safety testing, and support the development of fuel performance and fission product transport models. The first of these irradiation tests, designated AGR-1, began in the ATR in December 2006 and ended in November 2009. This experiment was conducted primarily to act as a shakedown test of the multicapsule test train design and provide early data on fuel performance for use in fuel fabrication process development. It also provided samples for post-irradiation safety testing, where fission product retention of the fuel at high temperatures will be experimentally measured. The capsule design and details of the AGR-1 experiment have been presented previously.« less

  18. APPLICATION OF BAYESIAN AND GEOSTATISTICAL MODELING TO THE ENVIRONMENTAL MONITORING OF CS-137 AT THE IDAHO NATIONAL LABORATORY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kara G. Eby

    2010-08-01

    At the Idaho National Laboratory (INL) Cs-137 concentrations above the U.S. Environmental Protection Agency risk-based threshold of 0.23 pCi/g may increase the risk of human mortality due to cancer. As a leader in nuclear research, the INL has been conducting nuclear activities for decades. Elevated anthropogenic radionuclide levels including Cs-137 are a result of atmospheric weapons testing, the Chernobyl accident, and nuclear activities occurring at the INL site. Therefore environmental monitoring and long-term surveillance of Cs-137 is required to evaluate risk. However, due to the large land area involved, frequent and comprehensive monitoring is limited. Developing a spatial model thatmore » predicts Cs-137 concentrations at unsampled locations will enhance the spatial characterization of Cs-137 in surface soils, provide guidance for an efficient monitoring program, and pinpoint areas requiring mitigation strategies. The predictive model presented herein is based on applied geostatistics using a Bayesian analysis of environmental characteristics across the INL site, which provides kriging spatial maps of both Cs-137 estimates and prediction errors. Comparisons are presented of two different kriging methods, showing that the use of secondary information (i.e., environmental characteristics) can provide improved prediction performance in some areas of the INL site.« less

  19. INL Cultural Resource Monitoring Report for FY 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pace, Brenda Ringe; Olson, Christina Liegh; Gilbert, Hollie Kae

    This report describes the cultural resource monitoring activities of the Idaho National Laboratory’s (INL) Cultural Resource Management (CRM) Office during fiscal year (FY) 2015. Throughout the year, 67 total monitoring visits were completed, with several especially sensitive resources visited on more than one occasion. Overall, FY 2015 monitoring included surveillance of the following 49 individual cultural resource localities: three locations with human remains, one of which is also a cave; nine additional caves; twenty prehistoric archaeological sites; five historic archaeological sites; two historic trails; Experimental Breeder Reactor I (EBR-I), a National Historic Landmark; Aircraft Nuclear Propulsion (ANP) objects located atmore » EBR-I; and eight Arco Naval Proving Ground (NPG) property types. Several INL work processes and projects were also monitored to confirm compliance with original INL CRM recommendations and assess the effects of ongoing work. On two occasions, ground disturbing activities within the boundaries of the Power Burst Facility/Critical Infrastructure Test Range Complex (PBF/CITRC) were observed by INL CRM staff prepared to respond to any additional finds of Native American human remains. Finally, the current location housing INL Archives and Special Collections was evaluated once. Most of the cultural resources monitored in FY 2015 exhibited no adverse impacts, resulting in Type 1 impact assessments. However, Type 2 impacts were noted 13 times. In one case, a portion of a historic trail was graded without prior review or coordination with the INL CRM Office, resulting in impacts to the surface of the trail and one archaeological site. Evidence of unauthorized artifact collection/ looting was also documented at three archaeological sites located along INL powerlines. Federal agents concluded a FY 2012 investigation by filing civil charges and levying fine under the Archaeological Resource Protection Act against one INL employee for this kind of illegal removal of artifacts from INL lands. Goodale‘s Cutoff of the Oregon Trail showed evidence of heavy use associated with grazing. A number of previously reported Type 2 impacts were also once again documented at the EBR-I National Historic Landmark, including spalling and deterioration of bricks due to inadequate drainage, minimal maintenance, and rodent infestation. The ANP engines and locomotive on display at the EBR-I Visitors Center also exhibited impacts related to long term exposure. Finally, most of the Arco NPG properties monitored at Central Facilities Area exhibited problems with lack of timely and appropriate maintenance as well as inadequate drainage. No new Type 3 or Type 4 impacts that adversely affected significant cultural resources and threatened National Register eligibility were documented in FY 2015.« less

  20. Recombination and positive selection contributed to the evolution of Listeria monocytogenes lineages III and IV, two distinct and well supported uncommon L. monocytogenes lineages.

    PubMed

    Tsai, Yeu-Harn Lucy; Maron, Steve B; McGann, Patrick; Nightingale, Kendra K; Wiedmann, Martin; Orsi, Renato H

    2011-12-01

    Listeriamonocytogenes lineages III and IV represent two uncommon lineages of the human and animal pathogen L. monocytogenes, characterized by occurrence of unusual phenotypic and genetic characteristics that differentiate them from the common lineages I and II. To gain further insights into the evolution of lineages III and IV, we amplified and sequenced housekeeping genes (i.e., gap, prs, purM, ribC, and sigB), internalin genes (i.e., inlA, inlB, inlC, inlG, inlC2, inlD, inlE, inlF, and inlH) and the virulence gene cluster containing prfA, plcA, hly, mpl, actA, and plcB for lineages III (n = 7) and IV (n = 4) isolates. Phylogenetic analyses of the sequences obtained along with previously reported sequence data for 40 isolates representing lineages I (n = 18), II (n = 21), and III (n = 1), showed that lineages III and IV represent divergent and monophyletic lineages. The virulence gene cluster as well as the inlAB operon were present in all isolates, with inlF absent from all lineages III and IV isolates. While all lineage IV isolates contained only inlC (in addition to inlAB), lineage III isolates showed considerable diversity with regard to internalin gene presence, including presence of (i) only inlC (n = 2), (ii) inlC and inlGC2DE (n = 3), (iii) only inlGC2DE (n = 2), and (iv) inlC and inlC2DE (n = 1). In addition to evidence for horizontal gene transfer events, among lineages III and IV isolates, in prs, actA, plcB, mpl, inlA, inlB, inlG, inlD, and inlE, we also found significant evidence for positive selection in the hly promoter region and, along the lineages III and IV branches, for actA (including in sites recognized for interactions with proteins involved in actin tail polymerization). In conclusion, lineages III and IV represent two distinct monophyletic groups with contributions of intragenic recombination to the evolution of their internalin genes as well as contributions of positive selection to evolution of the virulence genes island. Copyright © 2011 Elsevier B.V. All rights reserved.

  1. Project Execution Plan for the Remote Handled Low-Level Waste Disposal Project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Danny Anderson

    2014-07-01

    As part of ongoing cleanup activities at the Idaho National Laboratory (INL), closure of the Radioactive Waste Management Complex (RWMC) is proceeding under the Comprehensive Environmental Response, Compensation, and Liability Act (42 USC 9601 et seq. 1980). INL-generated radioactive waste has been disposed of at RWMC since 1952. The Subsurface Disposal Area (SDA) at RWMC accepted the bulk of INL’s contact and remote-handled low-level waste (LLW) for disposal. Disposal of contact-handled LLW and remote-handled LLW ion-exchange resins from the Advanced Test Reactor in the open pit of the SDA ceased September 30, 2008. Disposal of remote-handled LLW in concrete disposalmore » vaults at RWMC will continue until the facility is full or until it must be closed in preparation for final remediation of the SDA (approximately at the end of fiscal year FY 2017). The continuing nuclear mission of INL, associated ongoing and planned operations, and Naval spent fuel activities at the Naval Reactors Facility (NRF) require continued capability to appropriately dispose of contact and remote handled LLW. A programmatic analysis of disposal alternatives for contact and remote-handled LLW generated at INL was conducted by the INL contractor in Fiscal Year 2006; subsequent evaluations were completed in Fiscal Year 2007. The result of these analyses was a recommendation to the Department of Energy (DOE) that all contact-handled LLW generated after September 30, 2008, be disposed offsite, and that DOE proceed with a capital project to establish replacement remote-handled LLW disposal capability. An analysis of the alternatives for providing replacement remote-handled LLW disposal capability has been performed to support Critical Decision-1. The highest ranked alternative to provide this required capability has been determined to be the development of a new onsite remote-handled LLW disposal facility to replace the existing remote-handled LLW disposal vaults at the SDA. Several offsite DOE and commercial disposal options exist for contact-handled LLW; however, offsite disposal options are either not currently available (i.e., commercial disposal facilities), practical, or cost-effective for all remote-handled LLW streams generated at INL. Offsite disposal of all INL and tenant-generated remote-handled waste is further complicated by issues associated with transporting highly radioactive waste in commerce; and infrastructure and processing changes at the generating facilities, specifically NRF, that would be required to support offsite disposal. The INL Remote-Handled LLW Disposal Project will develop a new remote handled LLW disposal facility to meet mission-critical, remote-handled LLW disposal needs. A formal DOE decision to proceed with the project has been made in accordance with the requirements of National Environmental Policy Act (42 USC§ 4321 et seq.). Remote-handled LLW is generated from nuclear programs conducted at INL, including spent nuclear fuel handling and operations at NRF and operations at the Advanced Test Reactor. Remote-handled LLW also will be generated by new INL programs and from segregation and treatment (as necessary) of remote handled scrap and waste currently stored in the Radioactive Scrap and Waste Facility at the Materials and Fuels Complex.« less

  2. Idaho National Laboratory Cultural Resource Monitoring Report for FY 2010

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    INL Cultural Resource Management Office

    2010-10-01

    This report describes the cultural resource monitoring activities of the Idaho National Laboratory’s (INL) Cultural Resource Management (CRM) Office during fiscal year 2010 (FY 2010). Throughout the year, thirty-three cultural resource localities were revisited, including somethat were visited more than once, including: two locations with Native American human remains, one of which is a cave, two additional caves, twenty-six prehistoric archaeological sites, two historic stage stations, and Experimental Breeder Reactor-I, which is a designated National Historic Landmark. The resources that were monitored included seventeen that are routinely visited and sixteen that are located in INL project areas. Although impacts weremore » documented at a few locations and one trespassing incident (albeit sans formal charges) was discovered, no significant adverse effects that would threaten the National Register eligibility of any resources were observed. Monitoring also demonstrated that several INL projects generally remain in compliance with recommendations to protect cultural resources.« less

  3. Idaho National Laboratory Cultural Resource Management Annual Report FY 2006

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Clayton F. Marler; Julie Braun; Hollie Gilbert

    2007-04-01

    The Idaho National Laboratory Site is home to vast numbers and a wide variety of important cultural resources representing at least a 13,500-year span of human occupation in the region. As a federal agency, the Department of Energy Idaho Operations Office has legal responsibility for the management and protection of those resources and has delegated these responsibilities to its primary contractor, Battelle Energy Alliance (BEA). The INL Cultural Resource Management Office, staffed by BEA professionals, is committed to maintaining a cultural resource management program that accepts these challenges in a manner reflecting the resources’ importance in local, regional, and nationalmore » history. This annual report summarizes activities performed by the INL Cultural Resource Management Office staff during Fiscal Year 2006. This work is diverse, far-reaching and though generally confined to INL cultural resource compliance, also includes a myriad of professional and voluntary community activities. This document is intended to be both informative to internal and external stakeholders, and to serve as a planning tool for future cultural resource management work to be conducted on the INL.« less

  4. Idaho National Laboratory Cultural Resource Management Annual Report FY 2007

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Julie Braun; Hollie Gilbert; Dino Lowrey

    2008-03-01

    The Idaho National Laboratory (INL) Site is home to vast numbers and a wide variety of important cultural resources representing at least a 13,500-year span of human land use in the region. As a federal agency, the Department of Energy Idaho Operations Office has legal responsibility for the management and protection of those resources and has delegated these responsibilities to its primary contractor, Battelle Energy Alliance (BEA). The BEA professional staff is committed to maintaining a cultural resource management program that accepts these challenges in a manner reflecting the resources’ importance in local, regional, and national history. This annual reportmore » summarizes activities performed by the INL Cultural Resource Management Office (CRMO) staff during fiscal year 2007. This work is diverse, far-reaching and though generally confined to INL cultural resource compliance, also includes a myriad of professional and voluntary community activities. This document is intended to be both informative to internal and external stakeholders, and to serve as a planning tool for future cultural resource management work to be conducted on the INL.« less

  5. Technology Deployment Annual Report 2014 December

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arterburn, George K.

    This report is a summary of key Technology Deployment activities and achievements for 2014, including intellectual property, granted copyrights, royalties, license agreements, CRADAs, WFOs and Technology-Based Economic Development. Idaho National Laboratory (INL) is a Department of Energy (DOE) multi-program national laboratory that conducts research and development in all DOE mission areas. Like all other federal laboratories, INL has a statutory, technology transfer mission to make its capabilities and technologies available to all federal agencies, to state and local governments, and to universities and industry. To fulfill this mission, INL encourages its scientific, engineering, and technical staff to disclose new inventionsmore » and creations to ensure the resulting intellectual property is captured, protected, and made available to others who might benefit from it. As part of the mission, intellectual property is licensed to industrial partners for commercialization, creating jobs and delivering the benefits of federally funded technology to consumers. In other cases, unique capabilities are made available to other federal agencies or to regional small businesses to solve specific technical challenges. INL employees also work cooperatively with researchers and technical staff from the university and industrial sectors to further develop emerging technologies. In our multinational global economy, INL is contributing to the development of the next generation of engineers and scientists by licensing software to educational instiutitons throughout the world. This report is a catalog of selected INL technology transfer and commercialization transactions during this past year. The size and diversity of INL technical resources, coupled with the large number of relationships with other organizations, virtually ensures that a report of this nature will fail to capture all interactions. Recognizing this limitation, this report focuses on transactions that are specifically authorized by technology transfer legislation (and corresponding contractual provisions) or involve the transfer of legal rights to technology to other parties. This report was compiled from primary records, which were readily available to the INL’s Office of Technology Deployment. However, the accomplishments cataloged in the report reflect the achievements and creativity of the researchers, technicians, support staff, and operators of the INL workforce.« less

  6. Criticality Safety Basics for INL FMHs and CSOs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    V. L. Putman

    2012-04-01

    Nuclear power is a valuable and efficient energy alternative in our energy-intensive society. However, material that can generate nuclear power has properties that require this material be handled with caution. If improperly handled, a criticality accident could result, which could severely harm workers. This document is a modular self-study guide about Criticality Safety Principles. This guide's purpose it to help you work safely in areas where fissionable nuclear materials may be present, avoiding the severe radiological and programmatic impacts of a criticality accident. It is designed to stress the fundamental physical concepts behind criticality controls and the importance of criticalitymore » safety when handling fissionable materials outside nuclear reactors. This study guide was developed for fissionable-material-handler and criticality-safety-officer candidates to use with related web-based course 00INL189, BEA Criticality Safety Principles, and to help prepare for the course exams. These individuals must understand basic information presented here. This guide may also be useful to other Idaho National Laboratory personnel who must know criticality safety basics to perform their assignments safely or to design critically safe equipment or operations. This guide also includes additional information that will not be included in 00INL189 tests. The additional information is in appendices and paragraphs with headings that begin with 'Did you know,' or with, 'Been there Done that'. Fissionable-material-handler and criticality-safety-officer candidates may review additional information at their own discretion. This guide is revised as needed to reflect program changes, user requests, and better information. Issued in 2006, Revision 0 established the basic text and integrated various programs from former contractors. Revision 1 incorporates operation and program changes implemented since 2006. It also incorporates suggestions, clarifications, and additional information from readers and from personnel who took course 00INL189. Revision 1 also completely reorganized the training to better emphasize physical concepts behind the criticality controls that fissionable material handlers and criticality safety officers must understand. The reorganization is based on and consistent with changes made to course 00INL189 due to a review of course exam results and to discussions with personnel who conduct area-specific training.« less

  7. Applying DOE's Graded Approach for assessing radiation impacts to non-human biota at the INL.

    PubMed

    Morris, Randall C

    2006-01-01

    In July 2002, The US Department of Energy (DOE) released a new technical standard entitled A Graded Approach for Evaluating Radiation Doses to Aquatic and Terrestrial Biota. DOE facilities are annually required to demonstrate that routine radioactive releases from their sites are protective of non-human receptors and sites are encouraged to use the Graded Approach for this purpose. Use of the Graded Approach requires completion of several preliminary steps, to evaluate the degree to which the site environmental monitoring program is appropriate for evaluating impacts to non-human biota. We completed these necessary activities at the Idaho National Laboratory (INL) using the following four tasks: (1) develop conceptual models and evaluate exposure pathways; (2) define INL evaluation areas; (3) evaluate sampling locations and media; (4) evaluate data gaps. All of the information developed in the four steps was incorporated, data sources were identified, departures from the Graded Approach were justified, and a step-by-step procedure for biota dose assessment at the INL was specified. Finally, we completed a site-wide biota dose assessment using the 2002 environmental surveillance data and an offsite assessment using soil and surface water data collected since 1996. These assessments demonstrated the environmental concentrations of radionuclides measured on and near the INL do not present significant risks to populations of non-human biota.

  8. Ruminant Rhombencephalitis-Associated Listeria monocytogenes Alleles Linked to a Multilocus Variable-Number Tandem-Repeat Analysis Complex ▿ †

    PubMed Central

    Balandyté, Lina; Brodard, Isabelle; Frey, Joachim; Oevermann, Anna; Abril, Carlos

    2011-01-01

    Listeria monocytogenes is among the most important food-borne pathogens and is well adapted to persist in the environment. To gain insight into the genetic relatedness and potential virulence of L. monocytogenes strains causing central nervous system (CNS) infections, we used multilocus variable-number tandem-repeat analysis (MLVA) to subtype 183 L. monocytogenes isolates, most from ruminant rhombencephalitis and some from human patients, food, and the environment. Allelic-profile-based comparisons grouped L. monocytogenes strains mainly into three clonal complexes and linked single-locus variants (SLVs). Clonal complex A essentially consisted of isolates from human and ruminant brain samples. All but one rhombencephalitis isolate from cattle were located in clonal complex A. In contrast, food and environmental isolates mainly clustered into clonal complex C, and none was classified as clonal complex A. Isolates of the two main clonal complexes (A and C) obtained by MLVA were analyzed by PCR for the presence of 11 virulence-associated genes (prfA, actA, inlA, inlB, inlC, inlD, inlE, inlF, inlG, inlJ, and inlC2H). Virulence gene analysis revealed significant differences in the actA, inlF, inlG, and inlJ allelic profiles between clinical isolates (complex A) and nonclinical isolates (complex C). The association of particular alleles of actA, inlF, and newly described alleles of inlJ with isolates from CNS infections (particularly rhombencephalitis) suggests that these virulence genes participate in neurovirulence of L. monocytogenes. The overall absence of inlG in clinical complex A and its presence in complex C isolates suggests that the InlG protein is more relevant for the survival of L. monocytogenes in the environment. PMID:21984240

  9. Neutron radiography of irradiated nuclear fuel at Idaho National Laboratory

    DOE PAGES

    Craft, Aaron E.; Wachs, Daniel M.; Okuniewski, Maria A.; ...

    2015-09-10

    Neutron radiography of irradiated nuclear fuel provides more comprehensive information about the internal condition of irradiated nuclear fuel than any other non-destructive technique to date. Idaho National Laboratory (INL) has multiple nuclear fuels research and development programs that routinely evaluate irradiated fuels using neutron radiography. The Neutron Radiography reactor (NRAD) sits beneath a shielded hot cell facility where neutron radiography and other evaluation techniques are performed on these highly radioactive objects. The NRAD currently uses the foil-film transfer technique for imaging fuel that is time consuming but provides high spatial resolution. This study describes the NRAD and hot cell facilities,more » the current neutron radiography capabilities available at INL, planned upgrades to the neutron imaging systems, and new facilities being brought online at INL related to neutron imaging.« less

  10. Summary Report on Solid-oxide Electrolysis Cell Testing and Development

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J.E. O'Brien; X. Zhang; R.C. O'Brien

    2012-01-01

    Idaho National Laboratory (INL) has been researching the application of solid-oxide electrolysis cells (SOECs) for large-scale hydrogen production from steam over a temperature range of 800 to 900 C. From 2003 to 2009, this work was sponsored by the United States Department of Energy Nuclear Hydrogen Initiative, under the Office of Nuclear Energy. Starting in 2010, the high-temperature electrolysis (HTE) research program has been sponsored by the INL Next Generation Nuclear Plant Project. This report provides a summaryof program activities performed in Fiscal Year (FY) 2011 and the first quarter of FY-12, with a focus on small-scale testing and cellmore » development activities. HTE research priorities during this period have included the development and testing of SOEC and stack designs that exhibit high-efficiency initial performance and low, long-term degradation rates. This report includes contributions from INL and five industry partners: Materials and Systems Research, Incorporated (MSRI); Versa Power Systems, Incorporated (VPS); Ceramatec, Incorporated; National Aeronautics and Space Administration - Glenn Research Center (NASA - GRC); and the St. Gobain Advanced Materials Division. These industry partners have developed SOEC cells and stacks for in-house testing in the electrolysis mode and independent testing at INL. Additional fundamental research and post-test physical examinations have been performed at two university partners: Massachusetts Institute of Technology (MIT) and the University of Connecticut. Summaries of these activities and test results are also presented in this report.« less

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Michelle R. Blacker

    The Idaho National Laboratory (INL) is a Department of Energy (DOE) multi-program national laboratory that conducts research and development in all DOE mission areas. Like all other federal laboratories, INL has a statutory, technology transfer mission to make its capabilities and technologies available to all federal agencies, to state and local governments, and to universities and industry. To fulfill this mission, INL encourages its scientific, engineering, and technical staff to disclose new inventions and creations to ensure the resulting intellectual property is captured, protected, and made available to others who might benefit from it. As part of the mission, intellectualmore » property is licensed to industrial partners for commercialization, creating jobs and delivering the benefits of federally funded technology to consumers. In other cases, unique capabilities are made available to other federal agencies or to regional small businesses to solve specific technical challenges. In other interactions, INL employees work cooperatively with researchers and other technical staff of our partners to further develop emerging technologies. This report is a catalog of selected INL technology transfer and commercialization transactions during this past year. The size and diversity of INL technical resources, coupled with the large number of relationships with other organizations, virtually ensures that a report of this nature will fail to capture all interactions. Recognizing this limitation, this report focuses on transactions that are specifically authorized by technology transfer legislation (and corresponding contractual provisions) or involve the transfer of legal rights to technology to other parties. This report was compiled from primary records, which were readily available to the INL’s Office of Technology Transfer & Commercialization. The accomplishments cataloged in the report, however, reflect the achievements and creativity of the highly skilled researchers, technicians, support staff, and operators of the INL workforce. Their achievements and recognized capabilities are what make the accomplishments cataloged here possible. Without them, none of these transactions would occur.« less

  12. Feasibility of Ground Testing a Moon and Mars Surface Power Reactor in EBR-II

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sheryl Morton; Carl Baily; Tom Hill

    Ground testing of a surface fission power system would be necessary to verify the design and validate reactor performance to support safe and sustained human exploration of the Moon and Mars. The Idaho National Laboratory (INL) has several facilities that could be adapted to support a ground test. This paper focuses on the feasibility of ground testing at the Experimental Breeder Reactor II (EBR-II) facility and using other INL existing infrastructure to support such a test. This brief study concludes that the INL EBR-II facility and supporting infrastructure are a viable option for ground testing the surface power system. Itmore » provides features and attributes that offer advantages to locating and performing ground testing at this site, and it could support the National Aeronautics and Space Administration schedules for human exploration of the Moon. This study used the initial concept examined by the U.S. Department of Energy Inter-laboratory Design and Analysis Support Team for surface power, a lowtemperature, liquid-metal, three-loop Brayton power system. With some facility modification, the EBR-II can safely house a test chamber and perform long-term testing of the space reactor power system. The INL infrastructure is available to receive and provide bonded storage for special nuclear materials. Facilities adjacent to EBR-II can provide the clean room environment needed to assemble and store the test article assembly, disassemble the power system at the conclusion of testing, and perform posttest examination. Capability for waste disposal is also available at the INL.« less

  13. Feasibility of Ground Testing a Moon and Mars Surface Power Reactor in EBR-II

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Morton, Sheryl L.; Baily, Carl E.; Hill, Thomas J.

    Ground testing of a surface fission power system would be necessary to verify the design and validate reactor performance to support safe and sustained human exploration of the Moon and Mars. The Idaho National Laboratory (INL) has several facilities that could be adapted to support a ground test. This paper focuses on the feasibility of ground testing at the Experimental Breeder Reactor II (EBR-II) facility and using other INL existing infrastructure to support such a test. This brief study concludes that the INL EBR-II facility and supporting infrastructure are a viable option for ground testing the surface power system. Itmore » provides features and attributes that offer advantages to locating and performing ground testing at this site, and it could support the National Aeronautics and Space Administration schedules for human exploration of the Moon. This study used the initial concept examined by the U.S. Department of Energy Inter-laboratory Design and Analysis Support Team for surface power, a low-temperature, liquid-metal, three-loop Brayton power system. With some facility modification, the EBR-II can safely house a test chamber and perform long-term testing of the space reactor power system. The INL infrastructure is available to receive and provide bonded storage for special nuclear materials. Facilities adjacent to EBR-II can provide the clean room environment needed to assemble and store the test article assembly, disassemble the power system at the conclusion of testing, and perform posttest examination. Capability for waste disposal is also available at the INL.« less

  14. Feasibility of Ground Testing a Moon and Mars Surface Power Reactor in EBR-II

    NASA Astrophysics Data System (ADS)

    Morton, Sheryl L.; Baily, Carl E.; Hill, Thomas J.; Werner, James E.

    2006-01-01

    Ground testing of a surface fission power system would be necessary to verify the design and validate reactor performance to support safe and sustained human exploration of the Moon and Mars. The Idaho National Laboratory (INL) has several facilities that could be adapted to support a ground test. This paper focuses on the feasibility of ground testing at the Experimental Breeder Reactor II (EBR-II) facility and using other INL existing infrastructure to support such a test. This brief study concludes that the INL EBR-II facility and supporting infrastructure are a viable option for ground testing the surface power system. It provides features and attributes that offer advantages to locating and performing ground testing at this site, and it could support the National Aeronautics and Space Administration schedules for human exploration of the Moon. This study used the initial concept examined by the U.S. Department of Energy Inter-laboratory Design and Analysis Support Team for surface power, a low-temperature, liquid-metal, three-loop Brayton power system. With some facility modification, the EBR-II can safely house a test chamber and perform long-term testing of the space reactor power system. The INL infrastructure is available to receive and provide bonded storage for special nuclear materials. Facilities adjacent to EBR-II can provide the clean room environment needed to assemble and store the test article assembly, disassemble the power system at the conclusion of testing, and perform posttest examination. Capability for waste disposal is also available at the INL.

  15. Idaho National Laboratory Cultural Resource Monitoring Report for FY 2009

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brenda R. Pace; Julie B. Braun

    2009-10-01

    This report describes the cultural resource monitoring activities of the Idaho National Laboratory’s (INL) Cultural Resource Management (CRM) Office during fiscal year 2009 (FY 2009). Throughout the year, thirty-eight cultural resource localities were revisited including: two locations with Native American human remains, one of which is a cave, two additional caves, twenty-two prehistoric archaeological sites, six historic homesteads, two historic stage stations, two historic trails, and two nuclear resources, including Experimental Breeder Reactor-I, which is a designated National Historic Landmark. Several INL project areas were also monitored in FY 2009 to assess project compliance with cultural resource recommendations and monitormore » the effects of ongoing project activities. Although impacts were documented at a few locations and trespassing citations were issued in one instance, no significant adverse effects that would threaten the National Register eligibility of any resources were observed. Monitoring also demonstrated that several INL projects generally remain in compliance with recommendations to protect cultural resources.« less

  16. Development of Electrical Capacitance Sensors for Accident Tolerant Fuel (ATF) Testing at the Transient Reactor Test (TREAT) Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Maolong; Ryals, Matthew; Ali, Amir

    2016-08-01

    A variety of instruments are being developed and qualified to support the Accident Tolerant Fuels (ATF) program and future transient irradiations at the Transient Reactor Test (TREAT) facility at Idaho National Laboratory (INL). The University of New Mexico (UNM) is working with INL to develop capacitance-based void sensors for determining the timing of critical boiling phenomena in static capsule fuel testing and the volume-averaged void fraction in flow-boiling in-pile water loop fuel testing. The static capsule sensor developed at INL is a plate-type configuration, while UNM is utilizing a ring-type capacitance sensor. Each sensor design has been theoretically and experimentallymore » investigated at INL and UNM. Experiments are being performed at INL in an autoclave to investigate the performance of these sensors under representative Pressurized Water Reactor (PWR) conditions in a static capsule. Experiments have been performed at UNM using air-water two-phase flow to determine the sensitivity and time response of the capacitance sensor under a flow boiling configuration. Initial measurements from the capacitance sensor have demonstrated the validity of the concept to enable real-time measurement of void fraction. The next steps include designing the cabling interface with the flow loop at UNM for Reactivity Initiated Accident (RIA) ATF testing at TREAT and further characterization of the measurement response for each sensor under varying conditions by experiments and modeling.« less

  17. INL Seismic Monitoring Annual Report: January 1, 2013 to December 31, 2013

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Payne, Suzette Jackson; Bockholt, Blaine Matthew; Hodges, Jed M

    During 2013, the Idaho National Laboratory (INL) recorded 14,011 independent triggers and 7,355 triggers were manmade blasts and distant, regional, and local earthquakes. Within the region, the INL Seismic Monitoring program located 2,085 earthquakes and 150 man-made blasts. Near and within the 161-km radius of INL, 38 of these earthquakes had small to moderate size magnitudes that ranged from 3.0 to 4.2. Residents near 19 of the M>3.0 earthquakes reported ground shaking affects of these earthquakes to the U.S. Geological Survey. Also, five new seismic stations with broadband seismometers and accelerometers were installed near INL facility areas. These new stationsmore » were installed to collect earthquake data that can be used in future INL probabilistic seismic hazard analyses to reduce uncertainties of ground motion models. In 2013, 1,013 earthquakes were located within the 161-km radius of INL and three occurred within the eastern Snake River Plain (ESRP). The earthquakes included three swarms and a mainshock-aftershock sequence. The earthquakes were located northwest of the INL in the Basin and Range regions of Idaho and Montana and southeast of the ESRP in the Basin and Range region along the Idaho-Wyoming border. A swarm of >180 earthquakes occurred at Driggs, Idaho; the largest events had local magnitudes (ML) of 2.8 and 3.1 and were felt by residents. A less intense swarm of 64 earthquakes was located west of Jackson, Wyoming along the Idaho-Wyoming border. The largest event was a MW 3.8 that was felt by local residents. Southeast of Pocatello, Idaho an earthquake of ML 4.2 was followed by 18 aftershocks that included a ML 3.6. Both earthquakes were felt by residents near to the epicenters. Three earthquakes occurred within the ESRP and three other earthquakes were located at the northwest edge of the ESRP. The coda magnitude (Mc) 1.3 earthquake was located in the center of ESRP north of the Great Rift and at a depth of 45 km. To the west, an earthquake of Mc 0.7 was located at a depth of 37 km and at the northwestern end of the Great Rift. Four earthquakes, Mc 0.0, Mc 1.3, Mc 1.8, and Mc 1.1 were located north of the INL along the edge of the ESRP. The Mc 0.0 and 1.1 earthquakes were located just within the ESRP at depths less than 6 km.« less

  18. Weapons of Mass Destruction Technology Evaluation and Training Range

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kevin Larry Young

    2009-05-01

    The Idaho National Laboratory (INL) has a long history for providing technology evaluation and training for military and other federal level Weapons of Mass Destruction (WMD) response agencies. Currently there are many federal organizations and commercial companies developing technologies related to detecting, assessing, mitigating and protecting against hazards associated with a WMD event. Unfortunately, very few locations exist within the United States where WMD response technologies are realistically field tested and evaluated using real chemical, biological, radiological, nuclear and explosive materials. This is particularly true with biological and radiological hazards. Related to this lack of adequate WMD, multi-hazard technology testingmore » capability is the shortage of locations where WMD response teams can train using actual chemical, biological, and radiological material or highly realistic simulates. In response to these technology evaluation and training needs, the INL has assembled a consortium of subject matter experts from existing programs and identified dedicated resources for the purpose of establishing an all-hazards, WMD technology evaluation and training range. The author describes the challenges associated with creating the all-hazards WMD technology evaluation and training range and lists the technical, logistical and financial benefits of an all-hazards technology evaluation and training range. Current resources and capabilities for conducting all-hazard technology evaluation and training at the INL are identified. Existing technology evaluation and training programs at the INL related to radiological, biological and chemical hazards are highlighted, including successes and lessons learned. Finally, remaining gaps in WMD technology evaluation and training capabilities are identified along with recommendations for closing those gaps.« less

  19. NEET Enhanced Micro-Pocket Fission Detector for High Temperature Reactors - FY16 Status Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Unruh, Troy; Reichenberger, Michael; Stevenson, Sarah

    2016-09-01

    A collaboration between the Idaho National Laboratory (INL), the Kansas State University (KSU), and the French Atomic Energy Agency, Commissariat à l'Énergie Atomique et aux Energies Alternatives, (CEA), has been initiated by the Nuclear Energy Enabling Technologies (NEET) Advanced Sensors and Instrumentation (ASI) program for developing and testing High Temperature Micro-Pocket Fission Detectors (HT MPFD), which are compact fission chambers capable of simultaneously measuring thermal neutron flux, fast neutron flux and temperature within a single package for temperatures up to 800 °C. The MPFD technology utilizes a small, multi-purpose, robust, in-core fission chambers and thermocouple. As discussed within this report,more » the small size, variable sensitivity, and increased accuracy of the MPFD technology represent a revolutionary improvement over current methods used to support irradiations in US Material Test Reactors (MTRs). Previous research conducted through NEET ASI1-3 has shown that the MPFD technology could be made robust and was successfully tested in a reactor core. This new project will further the MPFD technology for higher temperature regimes and other reactor applications by developing a HT MPFD suitable for temperatures up to 800 °C. This report summarizes the research progress for year two of this three year project. Highlights from research accomplishments include: • Continuation of a joint collaboration between INL, KSU, and CEA. Note that CEA is participating at their own expense because of interest in this unique new sensor. • An updated parallel wire HT MPFD design was developed. • Program support for HT MPFD deployments was given to Accident Tolerant Fuels (ATF) and Advanced Gas-cooled Reactor (AGR) irradiation test programs. • Quality approved materials for HT MPFD construction were procured by irradiation test programs for upcoming deployments. • KSU improved and performed electrical contact and fissile material plating. • KSU delivered fissile HT MPFD parts to INL for final construction of HT MPFD prototype. • A prototype HT MPFD was constructed and analyzed at INL. • The HT MPFD has been modeled in MCNP to optimize the amount of fissile material deposition. • The HT MPFD has been modeled in MCNP to optimize the sensor location in the irradiation test. • The fissile material deposition is undergoing independent verifications. • Detector amplifier electronics have been revised and tested by KSU. • Several project meetings were held at INL and KSU to discuss the roles and responsibilities between INL, KSU, and CEA for development and deployment of the HT MPFDs. As documented in this report, FY16 funding has allowed the project to meet year two planned accomplishments to develop a HT MPFD. In addition, the accomplishments of this project have attracted independent funding from other Department of Energy Office of Nuclear Energy (DOE-NE) programs for MTR irradiations of the MPFD technology. These are significant opportunities for this NEET Enhanced Micro-Pocket Fission Detector for High Temperature Reactors project because the irradiation expense of these experiments could not be included in the original project scope.« less

  20. An investigation of the hydraulic performance of culvert grates.

    DOT National Transportation Integrated Search

    1990-11-01

    An experimental investigation of the hydraulic performance of culvert endsections is reported. Of particular concern is the effect on performance that the addition of safety gratings may have. The head-discharge characteristics for various model inle...

  1. Complications Associated with Long-Term Disposition of Newly-Generated Transuranic Waste: A National Laboratory Perspective

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    B.J. Orchard; L.A. Harvego; T.L. Carlson

    The Idaho National Laboratory (INL) is a multipurpose national laboratory delivering specialized science and engineering solutions for the U.S. Department of Energy (DOE). Sponsorship of INL was formally transferred to the DOE Office of Nuclear Energy, Science and Technology (NE) by Secretary Spencer Abraham in July 2002. The move to NE, and designation as the DOE lead nuclear energy laboratory for reactor technology, supports the nation’s expanding nuclear energy initiatives, placing INL at the center of work to develop advanced Generation IV nuclear energy systems; nuclear energy/hydrogen coproduction technology; advanced nuclear energy fuel cycle technologies; and providing national security answersmore » to national infrastructure needs. As a result of the Laboratory’s NE mission, INL generates both contact-handled and remote-handled transuranic (TRU) waste from ongoing operations. Generation rates are relatively small and fluctuate based on specific programs and project activities being conducted; however, the Laboratory will continue to generate TRU waste well into the future in association with the NE mission. Currently, plans and capabilities are being established to transfer INL’s contact-handled TRU waste to the Advanced Mixed Waste Treatment Plant (AMWTP) for certification and disposal to the Waste Isolation Pilot Plant (WIPP). Remote-handled TRU waste is currently placed in storage at the Materials and Fuels Complex (MFC). In an effort to minimize future liabilities associated with the INL NE mission, INL is evaluating and assessing options for the management and disposition of all its TRU waste on a real-time basis at time of generation. This paper summarizes near-term activities to minimize future re handling of INL’s TRU waste, as well as, potential complications associated with the long-term disposition of newly-generated TRU waste. Potential complications impacting the disposition of INL newly-generated TRU waste include, but are not limited to: 1) required remote-handled TRU packaging configuration(s) vs. current facility capabilities, 2) long-term NE mission activities, 3) WIPP certification requirements, and 4) budget considerations.« less

  2. Laboratory Directed Research and Development LDRD-FY-2011

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dena Tomchak

    2012-03-01

    This report provides a summary of the research conducted at the Idaho National Laboratory (INL) during Fiscal Year (FY) 2011. This report demonstrates the types of cutting edge research the INL is performing to help ensure the nation's energy security. The research conducted under this program is aligned with our strategic direction, benefits the Department of Energy (DOE) and is in compliance with DOE order 413.2B. This report summarizes the diverse research and development portfolio with emphasis on the DOE Office of Nuclear Energy (DOE-NE) mission, encompassing both advanced nuclear science and technology and underlying technologies.

  3. Virtual tour: INL's space battery facility

    ScienceCinema

    Johnson, Steve

    2018-05-07

    This virtual tour shows how INL fuels and tests nuclear power systems for deep space missions. To learn more about INL's contribution to the Mars Science Laboratory, visit http://www.inl.gov/marsrover.

  4. DIissolution of low enriched uranium from the experimental breeder reactor-II fuel stored at the Idaho National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daniel, G.; Rudisill, T.; Almond, P.

    The Idaho National Laboratory (INL) is actively engaged in the development of electrochemical processing technology for the treatment of fast reactor fuels using irradiated fuel from the Experimental Breeder Reactor-II (EBR-II) as the primary test material. The research and development (R&D) activities generate a low enriched uranium (LEU) metal product from the electrorefining of the EBR-II fuel and the subsequent consolidation and removal of chloride salts by the cathode processor. The LEU metal ingots from past R&D activities are currently stored at INL awaiting disposition. One potential disposition pathway is the shipment of the ingots to the Savannah River Sitemore » (SRS) for dissolution in H-Canyon. Carbon steel cans containing the LEU metal would be loaded into reusable charging bundles in the H-Canyon Crane Maintenance Area and charged to the 6.4D or 6.1D dissolver. The LEU dissolution would be accomplished as the final charge in a dissolver batch (following the dissolution of multiple charges of spent nuclear fuel (SNF)). The solution would then be purified and the 235U enrichment downblended to allow use of the U in commercial reactor fuel. To support this potential disposition path, the Savannah River National Laboratory (SRNL) developed a dissolution flowsheet for the LEU using samples of the material received from INL.« less

  5. Afghan National Police Training Program Would Benefit from Better Compliance with the Economy Act and Reimbursable Agreements

    DTIC Science & Technology

    2011-08-25

    Security Cooperation Agency INL Bureau of International Narcotics and Law Enforcement Affairs JSSP Justice Sector Security Program PAE Pacific...regional training centers. The programs were the Justice Sector Security Program ( JSSP ), the Corrections System Support Program (CSSP), and the...Civilian Police International. JSSP and CSSP are considered rule of law programs. Rule of law is most commonly understood to be a foundational

  6. ATRC Neutron Detector Testing Quick Look Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Troy C. Unruh; Benjamin M. Chase; Joy L. Rempe

    2013-08-01

    As part of the Advanced Test Reactor (ATR) National Scientific User Facility (NSUF) program, a joint Idaho State University (ISU) / French Alternative Energies and Atomic Energy Commission (CEA) / Idaho National Laboratory (INL) project was initiated in FY-10 to investigate the feasibility of using neutron sensors to provide online measurements of the neutron flux and fission reaction rate in the ATR Critical Facility (ATRC). A second objective was to provide initial neutron spectrum and flux distribution information for physics modeling and code validation using neutron activation based techniques in ATRC as well as ATR during depressurized operations. Detailed activationmore » spectrometry measurements were made in the flux traps and in selected fuel elements, along with standard fission rate distribution measurements at selected core locations. These measurements provide additional calibration data for the real-time sensors of interest as well as provide benchmark neutronics data that will be useful for the ATR Life Extension Program (LEP) Computational Methods and V&V Upgrade project. As part of this effort, techniques developed by Prof. George Imel will be applied by Idaho State University (ISU) for assessing the performance of various flux detectors to develop detailed procedures for initial and follow-on calibrations of these sensors. In addition to comparing data obtained from each type of detector, calculations will be performed to assess the performance of and reduce uncertainties in flux detection sensors and compare data obtained from these sensors with existing integral methods employed at the ATRC. The neutron detectors required for this project were provided to team participants at no cost. Activation detectors (foils and wires) from an existing, well-characterized INL inventory were employed. Furthermore, as part of an on-going ATR NSUF international cooperation, the CEA sent INL three miniature fission chambers (one for detecting fast flux and two for detecting thermal flux) with associated electronics for assessment. In addition, Prof. Imel, ISU, has access to an inventory of Self-Powered Neutron Detectors (SPNDs) with a range of response times as well as Back-to-Back (BTB) fission chambers from prior research he conducted at the Transient REActor Test Facility (TREAT) facility and Neutron RADiography (NRAD) reactors. Finally, SPNDs from the National Atomic Energy Commission of Argentina (CNEA) were provided in connection with the INL effort to upgrade ATR computational methods and V&V protocols that are underway as part of the ATR LEP. Work during fiscal year 2010 (FY10) focussed on design and construction of Experiment Guide Tubes (EGTs) for positioning the flux detectors in the ATRC N-16 locations as well as obtaining ATRC staff concurrence for the detector evaluations. Initial evaluations with CEA researchers were also started in FY10 but were cut short due to reactor reliability issues. Reactor availability issues caused experimental work to be delayed during FY11/12. In FY13, work resumed; and evaluations were completed. The objective of this "Quick Look" report is to summarize experimental activities performed from April 4, 2013 through May 16, 2013.« less

  7. Idaho National Laboratory Cultural Resource Monitoring Report for FY 2008

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brenda R. Pace

    2009-01-01

    This report describes the cultural resource monitoring activities of the Idaho National Laboratory’s (INL) Cultural Resource Management (CRM) Office during fiscal year 2008 (FY 2008). Throughout the year, 45 cultural resource localities were revisited including: two locations of heightened Shoshone-Bannock tribal sensitivity, four caves, one butte, twenty-eight prehistoric archaeological sites, three historic homesteads, two historic stage stations, one historic canal construction camp, three historic trails, and Experimental Breeder Reactor-I, which is a designated National Historic Landmark. Several INL project areas were also monitored in FY 2008 to assess project compliance with cultural resource recommendations, confirm the locations of previously recordedmore » cultural resources in relation to project activities, to assess the damage caused by fire-fighting efforts, and to watch for cultural materials during ground disturbing activities. Although impacts were documented at a few locations, no significant adverse effects that would threaten the National Register eligibility of any resource were observed. Monitoring also demonstrated that INL projects generally remain in compliance with recommendations to protect cultural resources« less

  8. Decoupling Internalization, Acidification and Phagosmal-Endosomal/Iysosomal Phagocytosis of Internalin A coated Beads in epithelial cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blanchette, C D; Woo, Y; Thomas, C

    2008-12-22

    Phagocytosis has been extensively examined in 'professional' phagocytic cells using pH sensitive dyes. However, in many of the previous studies, a separation between the end of internalization, beginning of acidification and completion of phagosomal-endosomal/lysosomal fusion was not clearly established, and in several cases, it was treated as a one-step process. In addition, very little work has been done to systematically examine phagosomal maturation in 'non-professional' phagocytic cells, such as epithelial cells. Therefore, in this study, we developed a simple and novel method to decouple and accurately measure particle internalization, phagosomal acidification and phagosomal-endosomal/lysosomal fusion in Madin-Darby Canine Kidney (MDCK) andmore » Caco-2 epithelial cells. Our method was developed using a pathogen mimetic system consisting of polystyrene beads coated with Internalin A (InlA), a membrane surface protein from Listeria monocytogenes known to trigger receptor-mediated internalization. We achieved independent measurements of the rates of internalization, phagosomal acidification and phagosomal-endosomal/lysosomal fusion in epithelial cells by combining the InlA-coated beads (InlA-beads) with antibody quenching, pH sensitive dyes and endosomal/lysosomal dyes, as follows: the rate of InlA bead internalization was measured via antibody quenching of a pH independent dye (Alexa488) conjugated to InlA-beads, the rate at which phagosomes containing internalized InlA beads became acidified was measured using a pH dependent dye (FITC) conjugated to the beads and the rate of phagosomal-endosomal/lysosomal fusion was measured using a combination of unlabeled InlA-beads and an endosomal/lysosomal dye. By performing these independent measurements under identical experimental conditions, we were able to decouple the three processes and establish time scales for each. In a separate set of experiments, we also exploited the phagosomal acidification process to demonstrate an additional, real31 time method for tracking bead binding, internalization and phagosomal acidification in both MDCK and Caco-2 cells, as well as 1 NIH 3T3 fibroblast cells, using FITC conjugated to InlA-beads or fibronectin-coated beads. Using this method, we found that the time scales for internalization, phagosomal acidification and phagosomal-endosomal/lysosomal fusion were 23-32 min, 3-4 min and 74-120 min, respectively, for epithelial cells, MDCK and Caco-2, which are slower than the kinetics observed in professional phagocytes such as macrophages. Both the static and real-time methods developed here are expected to be readily and broadly applicable, as they simply require conjugation of a fluorophore to a pathogen or mimetic of interest in combination with common cell labeling dyes, and are not limited to the InlA ligand or cell types used here. As such, these methods hold promise for future measurements of receptor-mediated internalization in other cell systems, e.g. other pathogen-host systems.« less

  9. Multi-Physics Simulation of TREAT Kinetics using MAMMOTH

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    DeHart, Mark; Gleicher, Frederick; Ortensi, Javier

    With the advent of next generation reactor systems and new fuel designs, the U.S. Department of Energy (DOE) has identified the need for the resumption of transient testing of nuclear fuels. DOE has decided that the Transient Reactor Test Facility (TREAT) at Idaho National Laboratory (INL) is best suited for future testing. TREAT is a thermal neutron spectrum nuclear test facility that is designed to test nuclear fuels in transient scenarios. These specific fuels transient tests range from simple temperature transients to full fuel melt accidents. The current TREAT core is driven by highly enriched uranium (HEU) dispersed in amore » graphite matrix (1:10000 U-235/C atom ratio). At the center of the core, fuel is removed allowing for the insertion of an experimental test vehicle. TREAT’s design provides experimental flexibility and inherent safety during neutron pulsing. This safety stems from the graphite in the driver fuel having a strong negative temperature coefficient of reactivity resulting from a thermal Maxwellian shift with increased leakage, as well as graphite acting as a temperature sink. Air cooling is available, but is generally used post-transient for heat removal. DOE and INL have expressed a desire to develop a simulation capability that will accurately model the experiments before they are irradiated at the facility, with an emphasis on effective and safe operation while minimizing experimental time and cost. At INL, the Multi-physics Object Oriented Simulation Environment (MOOSE) has been selected as the model development framework for this work. This paper describes the results of preliminary simulations of a TREAT fuel element under transient conditions using the MOOSE-based MAMMOTH reactor physics tool.« less

  10. Countering Overseas Threats: DOD and State Need to Address Gaps in Monitoring of Security Equipment Transferred to Lebanon

    DTIC Science & Technology

    2014-02-01

    the ISF—night vision devices and ceramic plates for bullet proof vests . With regard to these two articles, we found the following: • INL consulted...However, INL did not consult the directorate about ceramic plates , which INL provided for bullet proof vests that it transferred to the ISF in...did not consult with the directorate about the ceramic plates , INL officials said that INL would contact the directorate in the future about any

  11. ETR, TRA642. BASEMENT SPACE ALLOCATION FOR EXPERIMENTERS CA. 1966, SOUTHEAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR, TRA-642. BASEMENT SPACE ALLOCATION FOR EXPERIMENTERS CA. 1966, SOUTHEAST QUADRANT OF FLOOR. WESTINGHOUSE ATOMIC POWER DIVISION (WAPD) AND BETTIS ATOMIC POWER LABORATORY (BAPL) CONSUME MOST OF THE QUADRANT. PHILLIPS PETROLEUM COMPANY ETR-E-2256, 12/1966. INL INDEX NO. 532-0642-00-706-021256, REV. F. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  12. Final Report on ITER Task Agreement 81-10

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brad J. Merrill

    An International Thermonuclear Experimental Reactor (ITER) Implementing Task Agreement (ITA) on Magnet Safety was established between the ITER International Organization (IO) and the Idaho National Laboratory (INL) Fusion Safety Program (FSP) during calendar year 2004. The objectives of this ITA were to add new capabilities to the MAGARC code and to use this updated version of MAGARC to analyze unmitigated superconductor quench events for both poloidal field (PF) and toroidal field (TF) coils of the ITER design. This report documents the completion of the work scope for this ITA. Based on the results obtained for this ITA, an unmitigated quenchmore » event in an ITER larger PF coil does not appear to be as severe an accident as in an ITER TF coil.« less

  13. Online Monitoring of Induction Motors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McJunkin, Timothy R.; Agarwal, Vivek; Lybeck, Nancy Jean

    2016-01-01

    The online monitoring of active components project, under the Advanced Instrumentation, Information, and Control Technologies Pathway of the Light Water Reactor Sustainability Program, researched diagnostic and prognostic models for alternating current induction motors (IM). Idaho National Laboratory (INL) worked with the Electric Power Research Institute (EPRI) to augment and revise the fault signatures previously implemented in the Asset Fault Signature Database of EPRI’s Fleet Wide Prognostic and Health Management (FW PHM) Suite software. Induction Motor diagnostic models were researched using the experimental data collected by Idaho State University. Prognostic models were explored in the set of literature and through amore » limited experiment with 40HP to seek the Remaining Useful Life Database of the FW PHM Suite.« less

  14. Human Factors Engineering Bibliographic Series. Volume 5, 1967 Literature

    DTIC Science & Technology

    1976-03-01

    8217aining progracus designed to In- crease arn strength. There were 26 subects In each group. those In the experimental group, static and dyl’sic... experimental design over more usual classical procedures are Swq* gested.a’ 32,258 Cohen. 1t.l. CONTINUOUS VERSUS Tti. VISUAL FEEDSAX INl PRISM... experimental study was :?arformeed to evaluate, singly &no In combination, the effective- ness of a is-hr. training progrm and a set of visual aids designed to

  15. Analysis of Multilocus Sequence Typing and Virulence Characterization of Listeria monocytogenes Isolates from Chinese Retail Ready-to-Eat Food

    PubMed Central

    Wu, Shi; Wu, Qingping; Zhang, Jumei; Chen, Moutong; Guo, Weipeng

    2016-01-01

    Eighty Listeria monocytogenes isolates were obtained from Chinese retail ready-to-eat (RTE) food and were previously characterized with serotyping and antibiotic susceptibility tests. The aim of this study was to characterize the subtype and virulence potential of these L. monocytogenes isolates by multilocus sequence typing (MLST), virulence-associate genes, epidemic clones (ECs), and sequence analysis of the important virulence factor: internalin A (inlA). The result of MLST revealed that these L. monocytogenes isolates belonged to 14 different sequence types (STs). With the exception of four new STs (ST804, ST805, ST806, and ST807), all other STs observed in this study have been associated with human listeriosis and outbreaks to varying extents. Six virulence-associate genes (inlA, inlB, inlC, inlJ, hly, and llsX) were selected and their presence was investigated using PCR. All strains carried inlA, inlB, inlC, inlJ, and hly, whereas 38.8% (31/80) of strains harbored the listeriolysin S genes (llsX). A multiplex PCR assay was used to evaluate the presence of markers specific to epidemic clones of L. monocytogenes and identified 26.3% (21/80) of ECI in the 4b-4d-4e strains. Further study of inlA sequencing revealed that most strains contained the full-length InlA required for host cell invasion, whereas three mutations lead to premature stop codons (PMSC) within a novel PMSCs at position 326 (GAA → TAA). MLST and inlA sequence analysis results were concordant, and different virulence potentials within isolates were observed. These findings suggest that L. monocytogenes isolates from RTE food in China could be virulent and be capable of causing human illness. Furthermore, the STs and virulence profiles of L. monocytogenes isolates have significant implications for epidemiological and public health studies of this pathogen. PMID:26909076

  16. Analysis of Multilocus Sequence Typing and Virulence Characterization of Listeria monocytogenes Isolates from Chinese Retail Ready-to-Eat Food.

    PubMed

    Wu, Shi; Wu, Qingping; Zhang, Jumei; Chen, Moutong; Guo, Weipeng

    2016-01-01

    Eighty Listeria monocytogenes isolates were obtained from Chinese retail ready-to-eat (RTE) food and were previously characterized with serotyping and antibiotic susceptibility tests. The aim of this study was to characterize the subtype and virulence potential of these L. monocytogenes isolates by multilocus sequence typing (MLST), virulence-associate genes, epidemic clones (ECs), and sequence analysis of the important virulence factor: internalin A (inlA). The result of MLST revealed that these L. monocytogenes isolates belonged to 14 different sequence types (STs). With the exception of four new STs (ST804, ST805, ST806, and ST807), all other STs observed in this study have been associated with human listeriosis and outbreaks to varying extents. Six virulence-associate genes (inlA, inlB, inlC, inlJ, hly, and llsX) were selected and their presence was investigated using PCR. All strains carried inlA, inlB, inlC, inlJ, and hly, whereas 38.8% (31/80) of strains harbored the listeriolysin S genes (llsX). A multiplex PCR assay was used to evaluate the presence of markers specific to epidemic clones of L. monocytogenes and identified 26.3% (21/80) of ECI in the 4b-4d-4e strains. Further study of inlA sequencing revealed that most strains contained the full-length InlA required for host cell invasion, whereas three mutations lead to premature stop codons (PMSC) within a novel PMSCs at position 326 (GAA → TAA). MLST and inlA sequence analysis results were concordant, and different virulence potentials within isolates were observed. These findings suggest that L. monocytogenes isolates from RTE food in China could be virulent and be capable of causing human illness. Furthermore, the STs and virulence profiles of L. monocytogenes isolates have significant implications for epidemiological and public health studies of this pathogen.

  17. Space Nuclear Program INL's role in energizing exploration

    ScienceCinema

    Idaho National Laboratory

    2017-12-09

    Idaho National Laboratory is helping make space exploration possible with the development of radioisotope power systems, which can work in areas too harsh and too isolated in space where the suns rays cannot be used for energy.

  18. INL@Work Radiological Search & Response Training

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Turnage, Jennifer

    Dealing with radiological hazards is just part of the job for many INL scientists and engineers. Dodging bullets isn't. But some Department of Defense personnel may have to do both. INL employee Jennifer Turnage helps train soldiers in the art of detecting radiological and nuclear material. For more information about INL's research projects, visit http://www.facebook.com/idahonationallaboratory.

  19. INL@Work Radiological Search & Response Training

    ScienceCinema

    Turnage, Jennifer

    2017-12-13

    Dealing with radiological hazards is just part of the job for many INL scientists and engineers. Dodging bullets isn't. But some Department of Defense personnel may have to do both. INL employee Jennifer Turnage helps train soldiers in the art of detecting radiological and nuclear material. For more information about INL's research projects, visit http://www.facebook.com/idahonationallaboratory.

  20. gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes.

    PubMed

    Braun, L; Ghebrehiwet, B; Cossart, P

    2000-04-03

    InlB is a Listeria monocytogenes protein that promotes entry of the bacterium into mammalian cells by stimulating tyrosine phosphorylation of the adaptor proteins Gab1, Cbl and Shc, and activation of phosphatidyl- inositol (PI) 3-kinase. Using affinity chromatography and enzyme-linked immunosorbent assay, we demonstrate a direct interaction between InlB and the mammalian protein gC1q-R, the receptor of the globular part of the complement component C1q. Soluble C1q or anti-gC1q-R antibodies impair InlB-mediated entry. Transient transfection of GPC16 cells, which are non-permissive to InlB-mediated entry, with a plasmid-expressing human gC1q-R promotes entry of InlB-coated beads. Furthermore, several experiments indicate that membrane recruitment and activation of PI 3-kinase involve an InlB-gC1q-R interaction and that gC1q-R associates with Gab1 upon stimulation of Vero cells with InlB. Thus, gC1q-R constitutes a cellular receptor involved in InlB-mediated activation of PI 3-kinase and tyrosine phosphorylation of the adaptor protein Gab1. After E-cadherin, the receptor for internalin, gC1q-R is the second identified mammalian receptor promoting entry of L. monocytogenes into mammalian cells.

  1. Biomass Research Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kenney, Kevin; Wright, Christopher; Shelton-Davis,

    INL's mission is to achieve DOE's vision of supplying high-quality raw biomass; preprocessing biomass into advanced bioenergy feedstocks; and delivering bioenergy commodities to biorefineries. You can learn more about research like this at the lab's facebook site http://www.facebook.com/idahonationallaboratory.

  2. Biomass Research Program

    ScienceCinema

    Kenney, Kevin; Wright, Christopher; Shelton-Davis, Colleen

    2017-12-09

    INL's mission is to achieve DOE's vision of supplying high-quality raw biomass; preprocessing biomass into advanced bioenergy feedstocks; and delivering bioenergy commodities to biorefineries. You can learn more about research like this at the lab's facebook site http://www.facebook.com/idahonationallaboratory.

  3. Idaho National Laboratory Integrated Safety Management System FY 2016 Effectiveness Review and Declaration Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunt, Farren J.

    Idaho National Laboratory’s (INL’s) Integrated Safety Management System (ISMS) effectiveness review of fiscal year (FY) 2016 shows that INL has integrated management programs and safety elements throughout the oversight and operational activities performed at INL. The significant maturity of Contractor Assurance System (CAS) processes, as demonstrated across INL’s management systems and periodic reporting through the Management Review Meeting process, over the past two years has provided INL with current real-time understanding and knowledge pertaining to the health of the institution. INL’s sustained excellence of the Integrated Safety and effective implementation of the Worker Safety and Health Program is also evidencedmore » by other external validations and key indicators. In particular, external validations include VPP, ISO 14001, DOELAP accreditation, and key Laboratory level indicators such as ORPS (number, event frequency and severity); injury/illness indicators such as Days Away, Restricted and Transfer (DART) case rate, back & shoulder metric and open reporting indicators, demonstrate a continuous positive trend and therefore improved operational performance over the last few years. These indicators are also reflective of the Laboratory’s overall organizational and safety culture improvement. Notably, there has also been a step change in ESH&Q Leadership actions that have been recognized both locally and complex-wide. Notwithstanding, Laboratory management continues to monitor and take action on lower level negative trends in numerous areas including: Conduct of Operations, Work Control, Work Site Analysis, Risk Assessment, LO/TO, Fire Protection, and Life Safety Systems, to mention a few. While the number of severe injury cases has decreased, as evidenced by the reduction in the DART case rate, the two hand injuries and the fire truck/ambulance accident were of particular concern. Aggressive actions continue in order to understand the causes and define actions needed to prevent similar injuries and accidents in the future. While our injury rate is not where we want it to be, it is not the only indicator that defines our ISMS program, safety culture, and efforts to be a continuous learning organization. When reviewing the entire year’s performance, and all areas that integrate ISMS principles and core functions, INL has an “effective” ISMS program that is continually improving.« less

  4. Idaho National Laboratory Cultural Resource Monitoring Report for Fiscal Year 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gilbert, Hollie Kae; Holmer, Marie Pilkington; Olson, Christina Liegh

    This report describes the cultural resource monitoring activities of the Idaho National Laboratory’s (INL) Cultural Resource Management (CRM) Office during fiscal year (FY) 2016. Overall monitoring included surveillance of the following 23 individual cultural resource localities: two locations with human remains, one of which is also a cave; seven additional caves; six prehistoric archaeological sites; four historic archaeological sites; one historic trail; Experimental Breeder Reactor I (EBR-I), a National Historic Landmark; Aircraft Nuclear Propulsion (ANP) objects located at EBR-I; and one Arco Naval Proving Ground (NPG) property, CF-633 and related objects and structures. Several INL work processes and projects weremore » also monitored to confirm compliance with original INL CRM recommendations and assess the effects of ongoing work. On one occasion, ground disturbing activities within the boundaries of the Critical Infrastructure Test Range Complex (CITRC) were observed by INL CRM staff prepared to respond to any additional finds of Native American human remains. Additionally, the CRM office was notified during two Trespass Investigations conducted by INL Security. Most of the cultural resources monitored in FY 2016 exhibited no adverse impacts, resulting in Type 1 impact assessments. However, Type 2 impacts were noted five times. Three previously reported Type 2 impacts were once again documented at the EBR-I National Historic Landmark, including spalling and deterioration of bricks due to inadequate drainage, minimal maintenance, and rodent infestation. The ANP engines and locomotive on display at the EBR-I Visitors Center also exhibited impacts related to long term exposure. Finally, most of the Arco NPG properties monitored at Central Facilities Area exhibited problems with lack of timely and appropriate maintenance as well as inadequate drainage. No new Type 3 or Type 4 impacts that adversely affected significant cultural resources and threatened National Register eligibility were documented in FY 2016.« less

  5. Promotion of couples' voluntary HIV counseling and testing: a comparison of influence networks in Rwanda and Zambia.

    PubMed

    Kelley, April L; Hagaman, Ashley K; Wall, Kristin M; Karita, Etienne; Kilembe, William; Bayingana, Roger; Tichacek, Amanda; Kautzman, Michele; Allen, Susan A

    2016-08-08

    Many African adults do not know that partners in steady or cohabiting relationships can have different HIV test results. Despite WHO recommendations for couples' voluntary counseling and testing (CVCT), fewer than 10 % of couples have been jointly tested and counseled. We examine the roles and interactions of influential network leaders (INLs) and influential network agents (INAs) in promoting CVCT in Kigali, Rwanda and Lusaka, Zambia. INLs were identified in the faith-based, non-governmental, private, and health sectors. Each INL recruited and mentored several INAs who promoted CVCT. INLs and INAs were interviewed about demographic characteristics, promotional efforts, and working relationships. We also surveyed CVCT clients about sources of CVCT information. In Zambia, 53 INAs and 31 INLs were surveyed. In Rwanda, 33 INAs and 27 INLs were surveyed. Most (75 %-90 %) INAs believed that INL support was necessary for their promotional work. Zambian INLs reported being more engaged with their INAs than Rwandan INLs, with 58 % of Zambian INLs reporting that they gave a lot of support to their INAs versus 39 % in Rwanda. INAs in both Rwanda and Zambia reported promoting CVCT via group forums (77 %-97 %) and speaking to a community leader about CVCT (79 %-88 %) in the past month. More Rwandan INAs and INLs reported previous joint or individual HIV testing compared with their Zambian counterparts, of which more than half had not been tested. In Zambia and Rwanda, 1271 and 3895 CVCT clients were surveyed, respectively. Hearing about CVCT from INAs during one-on-one promotions was the most frequent source of information reported by clients in Zambia (71 %). In contrast, Rwandan couples who tested were more likely to have heard about CVCT from a previously tested couple (59 %). CVCT has long been endorsed for HIV prevention but few couples have been reached. Influential social networks can successfully promote evidence-based HIV prevention in Africa. Support from more senior INLs and group presentations leveraged INAs' one-on-one promotions. The INL/INA model was effective in promoting couples to seek joint HIV testing and counseling and may have broader application to other sub-Saharan African countries to sustainably increase CVCT uptake.

  6. INL@Work Hope Lee microbiologist

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Hope

    2010-01-01

    INL environmental microbiologist Hope Lee is working to develop and apply tools that clean contaminants out of ground water. You can learn more about INL's environmental projects at http://www.facebook.com/idahonationallaboratory.

  7. INL@Work Hope Lee microbiologist

    ScienceCinema

    Lee, Hope

    2018-02-07

    INL environmental microbiologist Hope Lee is working to develop and apply tools that clean contaminants out of ground water. You can learn more about INL's environmental projects at http://www.facebook.com/idahonationallaboratory.

  8. AGR-2: The first irradiation of French HTR fuel in Advanced Test Reactor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    T. Lambert; B. Grover; P. Guillermier

    AGR-2, the second irradiation of the US program for qualification of the NGNP fuel, is open to international participation within the scope of the Generation IV International Forum. In this frame, it includes in its multi-capsule irradiation rig an irradiation of French HTR fuel manufactured in the CAPRI line (GAIA facility at CEA/Cadarache and AREVA/CERCA compacting line at Romans). The AGR-2 irradiation is designed to place our first fabrications of HTR particles under operating conditions that are representative of ANTARES project while keeping close to the test range of the German fuel as much as possible, which is the referencemore » in terms of irradiation behavior. A few batches of particles and 12 fuel compacts were produced and characterized in 2009 by CEA and CERCA. The fuel main characteristics are in conformity with our specifications and in compliance with INL requirements. The AGR-2 experiment is based on the design and devices used in the first experiment of the AGR program. The design makes it possible to monitor the irradiation conditions and in particular, the temperature, the power and the fission products released from fuel particles. The in pile equipment consists of a multi-capsule device designed to simultaneously irradiate six independent capsules with temperature control. The out-of-core part consists of the equipment for actively controlling temperature and measuring the fission products release on-line. The target conditions for the irradiation experiment were defined with the aim of comparing the results obtained under irradiation with German particles along with the objectives of reaching burn-up and fluence targets to validate the behavior of our fuel in a significant range (15% FIMA – 5 × 1025 n/m2 at 600 EFPD with centerline fuel temperature about 1100 degrees C). These conditions have to be representative of ANTARES project characteristics. These target conditions were compared with final results from neutron and thermal design studies performed by INL team, and preliminary thermal mechanical ATLAS calculations were carried out by CEA from this pre-design. Despite the mean burn-up achieved in approximately 600 EFPD being a little high (16.3% FIMA max. associated with a low fluence up to 2.85 × 1025 n/m2), this irradiation will nevertheless encompass the range of irradiation effects covered in our experimental objectives (maximum stress peak at start of irradiation then sign inversion of the stress in the SiC layer). In addition, the fluence and burn-up acceleration factors are very similar to those of the German reference experiments. This experimental irradiation began in July 2010 in the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) and first results have been acquired.« less

  9. Wound healing potential of a dimeric InlB variant analyzed by in vitro experiments on re-epithelialization of human skin models.

    PubMed

    Kolditz, F; Krausze, J; Heinz, D W; Niemann, H H; Müller-Goymann, C C

    2014-02-01

    A constitutively dimeric truncated variant of internalin B (InlB321-CD), acting as stimulator of the receptor tyrosine kinase MET, was tested for dermal wound-healing potential. Due to a lack of the endogenous MET agonist HGF/SF in chronic wounds, HGF/SF substitution by an InlB321-CD-loaded hydrogel might be beneficial in chronic wound therapy. In this study, InlB321-CD in solution and incorporated in a hydrogel was tested for mitogenic effects on immortalized human dermal keratinocytes (HaCaT) with an MTT assay. Cell migration was investigated with a scratch assay on primary keratinocytes (PHK) and on HaCaT. For the latter, scratching needed to be mitomycin C-controlled. InlB321-CD effects on a model of human skin were analyzed histologically with respect to viability. InlB321-CD led to dose-dependent proliferative effects on HaCaT cells whereas the equimolar dose of monomeric InlB321 did not. Upon hydrogel incorporation of InlB321-CD its mitogenic activity for HaCaT cells was maintained thus confirming the hydrogel as a promising drug delivery system. Motogenic effects were shown on both HaCaT and PHK cells. InlB321-CD neither possesses cytotoxic effects on the viability of a human skin model nor alters its organotypic cell morphology. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. AGR-2 Final Data Qualification Report for U.S. Capsules - ATR Cycles 147A Through 154B

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pham, Binh T.; Einerson, Jeffrey J.

    2014-07-01

    This report provides the data qualification status of AGR-2 fuel irradiation experimental data in four U.S. capsules from all 15 Advanced Test Reactor (ATR) Cycles 147A, 148A, 148B, 149A, 149B, 150A, 150B, 151A, 151B, 152A, 152B, 153A, 153B, 154A, and 154B, as recorded in the Nuclear Data Management and Analysis System (NDMAS). Thus, this report covers data qualification status for the entire AGR-2 irradiation and will replace four previously issued AGR-2 data qualification reports (e.g., INL/EXT-11-22798, INL/EXT-12-26184, INL/EXT-13-29701, and INL/EXT-13-30750). During AGR-2 irradiation, two cycles, 152A and 153A, occurred when the ATR core was briefly at low power, so AGR-2more » irradiation data are not used for physics and thermal calculations. Also, two cycles, 150A and 153B, are Power Axial Locator Mechanism (PALM) cycles when the ATR power is higher than during normal cycles. During the first PALM cycle, 150A, the experiment was temporarily moved from the B-12 location to the ATR water canal and during the second PALM cycle, 153B, the experiment was temporarily moved from the B-12 location to the I-24 location to avoid being overheated. During the “Outage” cycle, 153A, seven flow meters were installed downstream from seven Fission Product Monitoring System (FPMS) monitors to measure flows from the monitors and these data are included in the NDMAS database.« less

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Farren Hunt

    Idaho National Laboratory (INL) performed an Annual Effectiveness Review of the Integrated Safety Management System (ISMS), per 48 Code of Federal Regulations (CFR) 970.5223 1, “Integration of Environment, Safety and Health into Work Planning and Execution.” The annual review assessed Integrated Safety Management (ISM) effectiveness, provided feedback to maintain system integrity, and identified target areas for focused improvements and assessments for fiscal year (FY) 2013. Results of the FY 2012 annual effectiveness review demonstrated that the INL’s ISMS program was significantly strengthened. Actions implemented by the INL demonstrate that the overall Integrated Safety Management System is sound and ensures safemore » and successful performance of work while protecting workers, the public, and environment. This report also provides several opportunities for improvement that will help further strengthen the ISM Program and the pursuit of safety excellence. Demonstrated leadership and commitment, continued surveillance, and dedicated resources have been instrumental in maturing a sound ISMS program. Based upon interviews with personnel, reviews of assurance activities, and analysis of ISMS process implementation, this effectiveness review concludes that ISM is institutionalized and is “Effective”.« less

  12. ATR Spent Fuel Options Study

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Connolly, Michael James; Bean, Thomas E.; Brower, Jeffrey O.

    The Advanced Test Reactor (ATR) is a materials and fuels test nuclear reactor that performs irradiation services for the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Naval Reactors, the National Nuclear Security Administration (NNSA), and other research programs. ATR achieved initial criticality in 1967 and is expected to operate in support of needed missions until the year 2050 or beyond. It is anticipated that ATR will generate approximately 105 spent nuclear fuel (SNF) elements per year through the year 2050. Idaho National Laboratory (INL) currently stores 2,008 ATR SNF elements in dry storage, 976 in wet storage,more » and expects to have 1,000 elements in wet storage before January 2017. A capability gap exists at INL for long-term (greater than the year 2050) management, in compliance with the Idaho Settlement Agreement (ISA), of ATR SNF until a monitored retrievable geological repository is open. INL has significant wet and dry storage capabilities that are owned by the DOE Office of Environmental Management (EM) and operated and managed by Fluor Idaho, which include the Idaho Nuclear Technology and Engineering Center’s (INTEC’s) CPP-666, CPP-749, and CPP-603. In addition, INL has other capabilities owned by DOE-NE and operated and managed by Battelle Energy Alliance, LLC (BEA), which are located at the Materials and Fuel Complex (MFC). Additional storage capabilities are located on the INL Site at the Naval Reactors Facility (NRF). Current INL SNF management planning, as defined in the Fluor Idaho contract, shows INTEC dry fuel storage, which is currently used for ATR SNF, will be nearly full after transfer of an additional 1,000 ATR SNF from wet storage. DOE-NE tasked BEA with identifying and analyzing options that have the potential to fulfill this capability gap. BEA assembled a team comprised of SNF management experts from Fluor Idaho, Savannah River Site (SRS), INL/BEA, and the MITRE Corp with an objective of developing and analyzing options for fulfilling the capability gap. This management options analysis is not an alternatives analysis as defined by DOE Order 413.3B; rather, it is an evaluation of near-term, mid term and long-term actions needed to fulfill the capability gap. The actions are described in sufficient detail to inform stakeholders and DOE decision makers regarding a potential path forward. The recommended path forward will inform Fiscal Year 2019 budget formulation, support potential National Environmental Policy Act (NEPA) analyses, and may or may not include capital asset projects.« less

  13. ETRCF, TRA654, INTERIOR. REACTOR OPERATED IN WATERFILLED TANK. CAMERA LOOKS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR-CF, TRA-654, INTERIOR. REACTOR OPERATED IN WATER-FILLED TANK. CAMERA LOOKS DOWN FROM ABOVE UPON LATER (NON-NUCLEAR) EXPERIMENTAL GEAR. INL NEGATIVE NO. HD24-1-1. Mike Crane, Photographer, ca. 2003 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  14. Airport Landside. Volume IV. Appendix A. ALSIM AUXILIARY and MAIN Programs.

    DTIC Science & Technology

    1982-06-01

    covered 12. Spern g Agen.cy Nope mid Addes.inl.ep rU.S. Department of Transportation Fnal Reporte. 98 Federal Aviation AdministrationJa. 17 -Se.98 Office...Volume III: ALSIM Calibration and Validation; and, Volume V: Appendix B ALSIM Subroutines. 17 . Key Words 1.Distriheties Statemawn GPSS-V IKHT 18...A-1-3 Enplaning Passenger Creation Section ............... A-1- 17 Program Control Section ............................ A-1-23 MAIN PROGRAM

  15. Batelle Energy Alliance, LLC (BEA) 2014 Annual report for Idaho National Laboratory (INL)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Alvarez, Juan; Allen, Todd

    2014-10-01

    This Fiscal Year (FY) 2014 annual report provides the Department of Energy (DOE) with BEA’s self-assessment of performance managing and operating the INL for the period ending September 30, 2014. After considering all of the information related to INL performance during the rating period against the Goals, Objectives and Notable Outcomes in the FY 2014 Performance Evaluation and Measurement Plan (PEMP), BEA believes it earned an overall grade closest to an A. The paragraphs below highlight how INL excelled in delivering innovative and impactful research across the three mission areas; how INL has successfully positioned itself for future growth andmore » sustainment; and how, through strong leadership, INL has set and implemented a strategic direction to ensure we meet and exceed the expectations of DOE and other customers. Attachments 1 through 5 provide additional detail on FY 2014 mission accomplishments, outline corporate contributions for success, highlight national and international awards and recognitions at the organization and individual levels, and describe the performance issues and challenges faced in FY 2014. • Attachment 1, “Self-Assessed PEMP Ratings” • Attachment 2, “INL Mission Accomplishments” • Attachment 3, “Battelle Energy Alliance, LLC Contributions to INL Success” • Attachment 4, “FY 2014 Awards, Recognition, Professional Roles and Certifications” • Attachment 5, “Performance Issues and Challenges.”« less

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mary Catherine Thelen; Todd R. Allen

    This is the 2010 ATR National Scientific User Facility Annual Report. This report provides an overview of the program for 2010, along with individual project reports from each of the university principal investigators. The report also describes the capabilities offered to university researchers here at INL and at the ATR NSUF partner facilities.

  17. In-core flux sensor evaluations at the ATR critical facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Troy Unruh; Benjamin Chase; Joy Rempe

    2014-09-01

    Flux detector evaluations were completed as part of a joint Idaho State University (ISU) / Idaho National Laboratory (INL) / French Atomic Energy commission (CEA) ATR National Scientific User Facility (ATR NSUF) project to compare the accuracy, response time, and long duration performance of several flux detectors. Special fixturing developed by INL allows real-time flux detectors to be inserted into various ATRC core positions and perform lobe power measurements, axial flux profile measurements, and detector cross-calibrations. Detectors initially evaluated in this program include the French Atomic Energy Commission (CEA)-developed miniature fission chambers; specialized self-powered neutron detectors (SPNDs) developed by themore » Argentinean National Energy Commission (CNEA); specially developed commercial SPNDs from Argonne National Laboratory. As shown in this article, data obtained from this program provides important insights related to flux detector accuracy and resolution for subsequent ATR and CEA experiments and flux data required for bench-marking models in the ATR V&V Upgrade Initiative.« less

  18. Listeria monocytogenes Isolates Carrying Virulence-Attenuating Mutations in Internalin A Are Commonly Isolated from Ready-to-Eat Food Processing Plant and Retail Environments.

    PubMed

    VAN Stelten, A; Roberts, A R; Manuel, C S; Nightingale, K K

    2016-10-01

    Listeria monocytogenes is a human foodborne pathogen that may cause an invasive disease known as listeriosis in susceptible individuals. Internalin A (InlA; encoded by inlA) is a virulence factor that facilitates crossing of host cell barriers by L. monocytogenes . At least 19 single nucleotide polymorphisms (SNPs) in inlA that result in a premature stop codon (PMSC) have been described worldwide. SNPs leading to a PMSC in inlA have been shown to be causally associated with attenuated virulence. L. monocytogenes pathogens carrying virulence-attenuating (VA) mutations in inlA have been commonly isolated from ready-to-eat (RTE) foods but rarely have been associated with human disease. This study was conducted to determine the prevalence of VA SNPs in inlA among L. monocytogenes from environments associated with RTE food production and handling. More than 700 L. monocytogenes isolates from RTE food processing plant (n = 409) and retail (n = 319) environments were screened for the presence of VA SNPs in inlA. Overall, 26.4% of isolates from RTE food processing plant and 32.6% of isolates from retail environments carried a VA mutation in inlA. Food contact surfaces sampled at retail establishments were significantly (P < 0.0001) more likely to be contaminated by a L. monocytogenes isolate carrying a VA mutation in inlA (56% of 55 isolates) compared with nonfood contact surfaces (28% of 264 isolates). Overall, a significant proportion of L. monocytogenes isolated from RTE food production and handling environments have reduced virulence. These data will be useful in the revision of current and the development of future risk assessments that incorporate strain-specific virulence parameters.

  19. Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing.

    PubMed

    Faralla, Cristina; Bastounis, Effie E; Ortega, Fabian E; Light, Samuel H; Rizzuto, Gabrielle; Nocadello, Salvatorre; Anderson, Wayne F; Robbins, Jennifer R; Theriot, Julie A; Bakardjiev, Anna I

    2018-05-30

    During pregnancy, the placenta protects the fetus against the maternal immune response, as well as bacterial and viral pathogens. Bacterial pathogens that have evolved specific mechanisms of breaching this barrier, such as Listeria monocytogenes, present a unique opportunity for learning how the placenta carries out its protective function. We previously identified the L. monocytogenes protein Internalin P (InlP) as a secreted virulence factor critical for placental infection. Here, we show that InlP, but not the highly similar L. monocytogenes internalin Lmo2027, binds to human afadin (encoded by AF-6), a protein associated with cell-cell junctions. A crystal structure of InlP reveals several unique features, including an extended leucine-rich repeat (LRR) domain with a distinctive Ca2+-binding site. Despite afadin's involvement in the formation of cell-cell junctions, MDCK epithelial cells expressing InlP displayed a decrease in the magnitude of the traction stresses they could exert on deformable substrates, similar to the decrease in traction exhibited by AF-6 knock-out MDCK cells. L. monocytogenes ΔinlP mutants were deficient in their ability to form actin-rich protrusions from the basal face of polarized epithelial monolayers, a necessary step in the crossing of such monolayers (transcytosis). A similar phenotype was observed for bacteria expressing an internal in-frame deletion in inlP (inlP ΔLRR5) that specifically disrupts its interaction with afadin. However, afadin deletion in the host cells did not rescue the transcytosis defect. We conclude that secreted InlP targets cytosolic afadin to specifically promote L. monocytogenes transcytosis across the basal face of epithelial monolayers, which may contribute to the crossing of the basement membrane during placental infection.

  20. Idaho National Laboratory (INL) Site Greenhouse Gas (GHG) Monitoring Plan - 40 CFR 98

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Deborah L. Layton; Kimberly Frerichs

    2011-12-01

    The purpose of this Greenhouse Gas (GHG) Monitoring Plan is to meet the monitoring plan requirements of Title 40 of the Code of Federal Regulations Part 98.3(g)(5). This GHG Monitoring Plan identifies procedures and methodologies used at the Idaho National Laboratory Site (INL Site) to collect data used for GHG emissions calculations and reporting requirements from stationary combustion and other regulated sources in accordance with 40 CFR 98, Subparts A and other applicable subparts. INL Site Contractors determined subpart applicability through the use of a checklist (Appendix A). Each facility/contractor reviews operations to determine which subparts are applicable and themore » results are compiled to determine which subparts are applicable to the INL Site. This plan is applicable to the 40 CFR 98-regulated activities managed by the INL Site contractors: Idaho National Laboratory (INL), Idaho Cleanup Project (ICP), Advanced Mixed Waste Treatment Project (AMWTP), and Naval Reactors Facilities (NRF).« less

  1. Idaho National Laboratory (INL) Site Greenhouse Gas (GHG) Monitoring Plan - 40 CFR 98

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Deborah L. Layton; Kimberly Frerichs

    2010-07-01

    The purpose of this Greenhouse Gas (GHG) Monitoring Plan is to meet the monitoring plan requirements of Title 40 of the Code of Federal Regulations Part 98.3(g)(5). This GHG Monitoring Plan identifies procedures and methodologies used at the Idaho National Laboratory Site (INL Site) to collect data used for GHG emissions calculations and reporting requirements from stationary combustion and other regulated sources in accordance with 40 CFR 98, Subparts A and other applicable subparts. INL Site Contractors determined subpart applicability through the use of a checklist (Appendix A). Each facility/contractor reviews operations to determine which subparts are applicable and themore » results are compiled to determine which subparts are applicable to the INL Site. This plan is applicable to the 40 CFR 98-regulated activities managed by the INL Site contractors: Idaho National Laboratory (INL), Idaho Cleanup Project (ICP), Advanced Mixed Waste Treatment Project (AMWTP), and Naval Reactors Facilities (NRF).« less

  2. Single Component Sorption-Desorption Test Experimental Design Approach Discussions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Phil WInston

    A task was identified within the fission-product-transport work package to develop a path forward for doing testing to determine behavior of volatile fission products behavior and to engage members of the NGNP community to advise and dissent on the approach. The following document is a summary of the discussions and the specific approaches suggested for components of the testing. Included in the summary isare the minutes of the conference call that was held with INL and external interested parties to elicit comments on the approaches brought forward by the INL participants. The conclusion was that an initial non-radioactive, single componentmore » test will be useful to establish the limits of currently available chemical detection methods, and to evaluated source-dispersion uniformity. In parallel, development of a real-time low-concentration monitoring method is believed to be useful in detecting rapid dispersion as well as desorption phenomena. Ultimately, the test cycle is expected to progress to the use of radio-traced species, simply because this method will allow the lowest possible detection limits. The consensus of the conference call was that there is no need for an in-core test because the duct and heat exchanger surfaces that will be the sorption target will be outside the main neutron flux and will not be affected by irradiation. Participants in the discussion and contributors to the INL approach were Jeffrey Berg, Pattrick Calderoni, Gary Groenewold, Paul Humrickhouse, Brad Merrill, and Phil Winston. Participants from outside the INL included David Hanson of General Atomics, Todd Allen, Tyler Gerczak, and Izabela Szlufarska of the University of Wisconsin, Gary Was, of the University of Michigan, Sudarshan Loyalka and Tushar Ghosh of the University of Missouri, and Robert Morris of Oak Ridge National Laboratory.« less

  3. Murinization of Internalin Extends Its Receptor Repertoire, Altering Listeria monocytogenes Cell Tropism and Host Responses

    PubMed Central

    Tsai, Yu-Huan; Disson, Olivier; Bierne, Hélène; Lecuit, Marc

    2013-01-01

    Listeria monocytogenes (Lm) is an invasive foodborne pathogen that leads to severe central nervous system and maternal-fetal infections. Lm ability to actively cross the intestinal barrier is one of its key pathogenic properties. Lm crosses the intestinal epithelium upon the interaction of its surface protein internalin (InlA) with its host receptor E-cadherin (Ecad). InlA-Ecad interaction is species-specific, does not occur in wild-type mice, but does in transgenic mice expressing human Ecad and knock-in mice expressing humanized mouse Ecad. To study listeriosis in wild-type mice, InlA has been “murinized” to interact with mouse Ecad. Here, we demonstrate that, unexpectedly, murinized InlA (InlAm) mediates not only Ecad-dependent internalization, but also N-cadherin-dependent internalization. Consequently, InlAm-expressing Lm targets not only goblet cells expressing luminally-accessible Ecad, as does Lm in humanized mice, but also targets villous M cells, which express luminally-accessible N-cadherin. This aberrant Lm portal of entry results in enhanced innate immune responses and intestinal barrier damage, both of which are not observed in wild-type Lm-infected humanized mice. Murinization of InlA therefore not only extends the host range of Lm, but also broadens its receptor repertoire, providing Lm with artifactual pathogenic properties. These results challenge the relevance of using InlAm-expressing Lm to study human listeriosis and in vivo host responses to this human pathogen. PMID:23737746

  4. Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses.

    PubMed

    Tsai, Yu-Huan; Disson, Olivier; Bierne, Hélène; Lecuit, Marc

    2013-01-01

    Listeria monocytogenes (Lm) is an invasive foodborne pathogen that leads to severe central nervous system and maternal-fetal infections. Lm ability to actively cross the intestinal barrier is one of its key pathogenic properties. Lm crosses the intestinal epithelium upon the interaction of its surface protein internalin (InlA) with its host receptor E-cadherin (Ecad). InlA-Ecad interaction is species-specific, does not occur in wild-type mice, but does in transgenic mice expressing human Ecad and knock-in mice expressing humanized mouse Ecad. To study listeriosis in wild-type mice, InlA has been "murinized" to interact with mouse Ecad. Here, we demonstrate that, unexpectedly, murinized InlA (InlA(m)) mediates not only Ecad-dependent internalization, but also N-cadherin-dependent internalization. Consequently, InlA(m)-expressing Lm targets not only goblet cells expressing luminally-accessible Ecad, as does Lm in humanized mice, but also targets villous M cells, which express luminally-accessible N-cadherin. This aberrant Lm portal of entry results in enhanced innate immune responses and intestinal barrier damage, both of which are not observed in wild-type Lm-infected humanized mice. Murinization of InlA therefore not only extends the host range of Lm, but also broadens its receptor repertoire, providing Lm with artifactual pathogenic properties. These results challenge the relevance of using InlA(m)-expressing Lm to study human listeriosis and in vivo host responses to this human pathogen.

  5. Special Inspector General for Afghanistan Reconstruction Quarterly Report to the United States Congress

    DTIC Science & Technology

    2011-04-30

    U.S. Justice Sector Support Program Operating under INL, the Justice Sector Support Program ( JSSP ) aims to develop the capacity of the Afghan criminal...investigators graduated from JSSP legal training programs.252 The JSSP also added to the number of U.S. and local Afghan lawyers on its staff, growing...drafting guidelines for an extension of the JSSP based on experiences in the preceding year. Anticipated changes include moving some functions into the

  6. INL's Data Center

    ScienceCinema

    Idaho National Laboratory - Brent Stacey, John Grossenbacher, Shane Johnson

    2017-12-09

    ICE STORM is a super computer procured by INL from a well-knowncomputer vendor, SGI. ICE STORM is rated as No. 64 on the list of ICE STORM is a super computer procured by INL from a well-knowncomputer vendor, SGI. ICE STORM is rated as No. 64 on the lis

  7. HORIZONTAL BEAM HOLE NO. 3. PLUG AND RADIATION DOOR HAVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HORIZONTAL BEAM HOLE NO. 3. PLUG AND RADIATION DOOR HAVE BEEN REMOVED. EXPERIMENTAL APPARATUS WAS INSERTED INTO THE HOLE. NOTE VALVE CUBICLES NEAR FLOOR ON EACH SIDE OF HB-3. INL NEGATIVE NO. 3471. Unknown Photographer, 10/12/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  8. Wind Farm Recommendation Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    John Reisenauer

    On April 21, 2011, an Idaho National Laboratory (INL) Land Use Committee meeting was convened to develop a wind farm recommendation for the Executive Council and a list of proposed actions for proceeding with the recommendation. In terms of land use, the INL Land Use Committee unanimously agrees that Site 6 is the preferred location of the alternatives presented for an INL wind farm. However, further studies and resolution to questions raised (stated in this report) by the INL Land Use Committee are needed for the preferred location. Studies include, but are not limited to, wind viability (6 months), batsmore » (2 years), and the visual impact of the wind farm. In addition, cultural resource surveys and consultation (1 month) and the National Environmental Policy Act process (9 to 12 months) need to be completed. Furthermore, there is no documented evidence of developers expressing interest in constructing a small wind farm on INL, nor a specific list of expectations or concessions for which a developer might expect INL to cover the cost. To date, INL assumes the National Environmental Policy Act activities will be paid for by the Department of Energy and INL (the environmental assessment has only received partial funding). However, other concessions also may be expected by developers such as roads, fencing, power line installation, tie-ins to substations, annual maintenance, snow removal, access control, down-time, and remediation. These types of concessions have not been documented, as a request, from a developer and INL has not identified the short and long-term cost liabilities for such concessions should a developer expect INL to cover these costs. INL has not identified a go-no-go funding level or the priority this Wind Farm Project might have with respect to other nuclear-related projects, should the wind farm remain an unfunded mandate. The Land Use Committee recommends Legal be consulted to determine what, if any, liabilities exist with the Wind Farm Project and INL’s rights and responsibilities in regards to access to the wind farm once constructed. An expression of interest is expected to go out soon to developers. However, with the potential of 2 years of study remaining for Site 6, the expectation of obtaining meaningful interest from developers should be questioned.« less

  9. NEET Enhanced Micro Pocket Fission Detector for High Temperature Reactors - FY15 Status Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Unruh, Troy; McGregor, Douglas; Ugorowski, Phil

    2015-09-01

    A new project, that is a collaboration between the Idaho National Laboratory (INL), the Kansas State University (KSU), and the French Atomic Energy Agency, Commissariat à l'Énergie Atomique et aux Energies Alternatives, (CEA), has been initiated by the Nuclear Energy Enabling Technologies (NEET) Advanced Sensors and Instrumentation (ASI) program for developing and testing High Temperature Micro-Pocket Fission Detectors (HT MPFD), which are compact fission chambers capable of simultaneously measuring thermal neutron flux, fast neutron flux and temperature within a single package for temperatures up to 800 °C. The MPFD technology utilizes a small, multi-purpose, robust, in-core parallel plate fission chambermore » and thermocouple. As discussed within this report, the small size, variable sensitivity, and increased accuracy of the MPFD technology represent a revolutionary improvement over current methods used to support irradiations in US Material Test Reactors (MTRs). Previous research conducted through NEET ASI1-3 has shown that the MPFD technology could be made robust and was successfully tested in a reactor core. This new project will further the MPFD technology for higher temperature regimes and other reactor applications by developing a HT MPFD suitable for temperatures up to 800 °C. This report summarizes the research progress for year one of this three year project. Highlights from research accomplishments include: A joint collaboration was initiated between INL, KSU, and CEA. Note that CEA is participating at their own expense because of interest in this unique new sensor. An updated HT MPFD design was developed. New high temperature-compatible materials for HT MPFD construction were procured. Construction methods to support the new design were evaluated at INL. Laboratory evaluations of HT MPFD were initiated. Electrical contact and fissile material plating has been performed at KSU. Updated detector electronics are undergoing evaluations at KSU. A project meeting was held at KSU to discuss the roles and responsibilities between INL and KSU for development of the HT MPFDs. Provide input to various irradiation programs for installation of the MPFD technology in irradiation tests. As documented in this report, FY15 funding has allowed the project to meet year one planned accomplishments to develop a HT MPFD that offers US MTR users enhanced capabilities for real-time measurement of flux and temperature with a single detector. In addition, the accomplishments of this project have attracted funding from other Department of Energy Office of Nuclear Energy (DOE-NE) programs for additional applications. The work in those programs will build on current activities completed in this NEETASI HT MPFD project, but the MPFD will be specifically tailored to meet their program needs.« less

  10. Idaho National Laboratory LDRD Annual Report FY 2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dena Tomchak

    This report provides a glimpse into our diverse research and development portfolio, wwhich encompasses both advanced nuclear science and technology and underlying technologies. IN keeping with the mission, INL's LDRD program fosters technical capabilities necessary to support current and future DOE-Office of Nuclear Energy research and development needs.

  11. Accelerator Generation and Thermal Separation (AGATS) of Technetium-99m

    ScienceCinema

    Grover, Blaine

    2018-05-01

    Accelerator Generation and Thermal Separation (AGATS) of Technetium-99m is a linear electron accelerator-based technology for producing medical imaging radioisotopes from a separation process that heats, vaporizes and condenses the desired radioisotope. You can learn more about INL's education programs at http://www.facebook.com/idahonationallaboratory.

  12. Effects of Levels of Automation for Advanced Small Modular Reactors: Impacts on Performance, Workload, and Situation Awareness

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Johanna Oxstrand; Katya Le Blanc

    The Human-Automation Collaboration (HAC) research effort is a part of the Department of Energy (DOE) sponsored Advanced Small Modular Reactor (AdvSMR) program conducted at Idaho National Laboratory (INL). The DOE AdvSMR program focuses on plant design and management, reduction of capital costs as well as plant operations and maintenance costs (O&M), and factory production costs benefits.

  13. Fiscal Year 2014: Comprehensive Oversight Plan for Southwest Asia

    DTIC Science & Technology

    2013-09-30

    rule of law. We plan to focus primarily on DOS Bureau of International Narcotics and Law Enforcement (INL) Justice Sector Support Program ( JSSP ...Specifically, (1) assess whether JSSP contractor(s) provided qualified trainers and services in accordance with the terms of the contract(s); (2...and USAID justice sector training efforts and determine the extent to which these programs complement the JSSP . (Project: SIGAR-073A) Dec-12 Oct-13

  14. Airborne Dust Cloud Measurements at the INL National Security Test Range

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Michael L. Abbott; Norm Stanley; Larry Radke

    2007-09-01

    On July 11, 2007, a surface, high-explosive test (<20,000 lb TNT-equivalent) was carried out at the National Security Test Range (NSTR) on the Idaho National Laboratory (INL) Site. Aircraft-mounted rapid response (1-sec) particulate monitors were used to measure airborne PM-10 concentrations directly in the dust cloud and to develop a PM-10 emission factor that could be used for subsequent tests at the NSTR. The blast produced a mushroom-like dust cloud that rose approximately 2,500–3,000 ft above ground level, which quickly dissipated (within 5 miles of the source). In general, the cloud was smaller and less persistence than expected, or thatmore » might occur in other areas, likely due to the coarse sand and subsurface conditions that characterize the immediate NSTR area. Maximum short time-averaged (1-sec) PM-10 concentrations at the center of the cloud immediately after the event reached 421 µg m-3 but were rapidly reduced (by atmospheric dispersion and fallout) to near background levels (~10 µg m-3) after about 15 minutes. This occurred well within the INL Site boundary, about 8 km (5 miles) from the NSTR source. These findings demonstrate that maximum concentrations in ambient air beyond the INL Site boundary (closest is 11.2 km from NSTR) from these types of tests would be well within the 150 µg m-3 24-hour National Ambient Air Quality Standards for PM-10. Aircraft measurements and geostatistical techniques were used to successfully quantify the initial volume (1.64E+9 m3 or 1.64 km3) and mass (250 kg) of the PM-10 dust cloud, and a PM-10 emission factor (20 kg m-3 crater soil volume) was developed for this specific type of event at NSTR. The 250 kg of PM-10 mass estimated from this experiment is almost seven-times higher than the 36 kg estimated for the environmental assessment (DOE-ID 2007) using available Environmental Protection Agency (EPA 1995) emission factors. This experiment demonstrated that advanced aircraft-mounted instruments operated by experienced atmospheric research groups, such as the INL and Airborne Research Consultants LLC team, can safely and effectively assess difficult air pollutant questions at the INL Site and elsewhere that cannot be otherwise answered. This site-specific, measurement-based assessment provides valuable input to stakeholders in judging the risks associated with these types of events and NSTR project staff in the development of future experimental design and environmental impact assessments.« less

  15. Geochemistry of groundwater in the eastern Snake River Plain aquifer, Idaho National Laboratory and vicinity, eastern Idaho

    USGS Publications Warehouse

    Rattray, Gordon W.

    2018-05-30

    Nuclear research activities at the U.S. Department of Energy (DOE) Idaho National Laboratory (INL) in eastern Idaho produced radiochemical and chemical wastes that were discharged to the subsurface, resulting in detectable concentrations of some waste constituents in the eastern Snake River Plain (ESRP) aquifer. These waste constituents may pose risks to the water quality of the aquifer. In order to understand these risks to water quality the U.S. Geological Survey, in cooperation with the DOE, conducted a study of groundwater geochemistry to improve the understanding of hydrologic and chemical processes in the ESRP aquifer at and near the INL and to understand how these processes affect waste constituents in the aquifer.Geochemistry data were used to identify sources of recharge, mixing of water, and directions of groundwater flow in the ESRP aquifer at the INL. The geochemistry data were analyzed from 167 sample sites at and near the INL. The sites included 150 groundwater, 13 surface-water, and 4 geothermal-water sites. The data were collected between 1952 and 2012, although most data collected at the INL were collected from 1989 to 1996. Water samples were analyzed for all or most of the following: field parameters, dissolved gases, major ions, dissolved metals, isotope ratios, and environmental tracers.Sources of recharge identified at the INL were regional groundwater, groundwater from the Little Lost River (LLR) and Birch Creek (BC) valleys, groundwater from the Lost River Range, geothermal water, and surface water from the Big Lost River (BLR), LLR, and BC. Recharge from the BLR that may have occurred during the last glacial epoch, or paleorecharge, may be present at several wells in the southwestern part of the INL. Mixing of water at the INL primarily included mixing of surface water with groundwater from the tributary valleys and mixing of geothermal water with regional groundwater. Additionally, a zone of mixing between tributary valley water and regional groundwater, trending southwesterly, extended from near the northeastern boundary of the INL to the southern boundary of the INL. Groundwater flow directions for regional groundwater were southwesterly, and flow directions for tributary groundwater were southeasterly upon entering the ESRP, but eventually began to flow southwesterly in a direction parallel with regional groundwater. Several discrepancies were identified from comparison of sources of recharge determined from geochemistry data and backward particle tracking with a groundwater-flow model. Some discrepancies observed in the particle tracking results included representation of recharge from BC near the north INL boundary, groundwater from the BC valley not extending far enough south, regional groundwater that extends too far west in the southern part of the INL, and no representation of recharge from geothermal water in model layer 1 or recharge from the BLR in the southwestern part of the INL.

  16. Center for Advanced Modeling and Simulation Intern

    ScienceCinema

    Gertman, Vanessa

    2017-12-13

    Some interns just copy papers and seal envelopes. Not at INL! Check out how Vanessa Gertman, an INL intern working at the Center for Advanced Modeling and Simulation, spent her summer working with some intense visualization software. Lots more content like this is available at INL's facebook page http://www.facebook.com/idahonationallaboratory.

  17. Center for Advanced Modeling and Simulation Intern

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gertman, Vanessa

    Some interns just copy papers and seal envelopes. Not at INL! Check out how Vanessa Gertman, an INL intern working at the Center for Advanced Modeling and Simulation, spent her summer working with some intense visualization software. Lots more content like this is available at INL's facebook page http://www.facebook.com/idahonationallaboratory.

  18. ICD Complex Operations and Maintenance Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gibson, P. L.

    2007-06-25

    This Operations and Maintenance (O&M) Plan describes how the Idaho National Laboratory (INL) conducts operations, winterization, and startup of the Idaho CERCLA Disposal Facility (ICDF) Complex. The ICDF Complex is the centralized INL facility responsible for the receipt, storage, treatment (as necessary), and disposal of INL Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) remediation waste.

  19. Thermal Properties Measurement Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carmack, Jon; Braase, Lori; Papesch, Cynthia

    2015-08-01

    The Thermal Properties Measurement Report summarizes the research, development, installation, and initial use of significant experimental thermal property characterization capabilities at the INL in FY 2015. These new capabilities were used to characterize a U 3Si 2 (candidate Accident Tolerant) fuel sample fabricated at the INL. The ability to perform measurements at various length scales is important and provides additional data that is not currently in the literature. However, the real value of the data will be in accomplishing a phenomenological understanding of the thermal conductivity in fuels and the ties to predictive modeling. Thus, the MARMOT advanced modeling andmore » simulation capability was utilized to illustrate how the microstructural data can be modeled and compared with bulk characterization data. A scientific method was established for thermal property measurement capability on irradiated nuclear fuel samples, which will be installed in the Irradiated Material Characterization Laboratory (IMCL).« less

  20. Adult Diabetic Patients’ Self-Care Levels, Attitudes, and Perceptions Following an Education Program.

    DTIC Science & Technology

    1983-01-01

    hospital. Diabetes care, 1981, 4,. 487-489. Graber, A. L., Christman, B. G., Alogna, M, T., & Davidson, J. K. Evaluation of diabetes patient - education programs...L. Why patient education ? An elookate thow doatientwt diabeter elts c:j~inlHat Nurs ngOulo, 1979, 27, 71-75 7-11. Leie .(E..Idviulzn.hea.• atrt-ne...Salzer, J. E. Classes to improve diabetic self-care. American Journal of Nursing, 1975, 75, 1324-1326. Svtall, D. A patient education program. American

  1. INL Seismic Monitoring Annual Report: January 1, 2006 - December 31, 2006

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    S. J. Payne; N. S. Carpenter; J. M. Hodges

    During 2006, the Idaho National Laboratory (INL) recorded 1998 independent triggers from earthquakes both within the region and from around the world. Fifteen small to moderate size earthquakes ranging in magnitude from 3.0 to 4.5 occurred within and outside the 161-km (100-mile) radius of INL. There were 357 earthquakes with magnitudes up to 4.5 that occurred within the 161-km radius of the INL. The majority of earthquakes occurred in the Basin and Range Province surrounding the eastern Snake River Plain (ESRP). The largest of these earthquakes had a body-wave magnitude (mb) 4.5 and occurred on February 5, 2006. It wasmore » located northeast of Spencer, Idaho near the east-west trending Centennial fault along the Idaho-Montana border. The earthquake did not trigger SMAs located within INL buildings. Three earthquakes occurred within the ESRP, two of which occurred within the INL boundaries. One earthquake of coda magnitude (Mc) 1.7 occurred on October 18, 2006 and was located southeast of Pocatello, Idaho. The two earthquakes within the INL boundaries included the local magnitude (ML) 2.0 on July 31, 2006 located near the southern termination of the Lemhi fault and the Mc 0.4 on August 6, 2006 located near the center of INL. The ML 2.0 earthquake was well recorded by most of the INL seismic stations and had a focal depth of 8.98 km. First motions were used to compute a focal mechanism, which indicated normal faulting along one of two possible fault planes that may strike N76ºW and dip 70±3ºSW or strike N55ºW and dip 20±13ºNE. Slip along a normal fault that strikes N76ºW and dips 70±3ºSW is consistent with slip along a possible segment of the NW-trending Lemhi normal fault.« less

  2. Powering Mars Rovers

    ScienceCinema

    Stewert, Robin

    2018-01-15

    INL scientists are doing their best to help solve our energy problems here on Earth. But did you know the lab is playing a key role in the exploration of other worlds, too? Meet INL Engineer Robin Stewart helps build and test generators that power NASA missions to Pluto and Mars. You can learn more about INL projects at http://www.facebook.com/idahonationallaboratory.

  3. Feasibility of processing the experimental breeder reactor-II driver fuel from the Idaho National Laboratory through Savannah River Site's H-Canyon facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Magoulas, V. E.

    Savannah River National Laboratory (SRNL) was requested to evaluate the potential to receive and process the Idaho National Laboratory (INL) uranium (U) recovered from the Experimental Breeder Reactor II (EBR-II) driver fuel through the Savannah River Site’s (SRS) H-Canyon as a way to disposition the material. INL recovers the uranium from the sodium bonded metallic fuel irradiated in the EBR-II reactor using an electrorefining process. There were two compositions of EBR-II driver fuel. The early generation fuel was U-5Fs, which consisted of 95% U metal alloyed with 5% noble metal elements “fissium” (2.5% molybdenum, 2.0% ruthenium, 0.3% rhodium, 0.1% palladium,more » and 0.1% zirconium), while the later generation was U-10Zr which was 90% U metal alloyed with 10% zirconium. A potential concern during the H-Canyon nitric acid dissolution process of the U metal containing zirconium (Zr) is the explosive behavior that has been reported for alloys of these materials. For this reason, this evaluation was focused on the ability to process the lower Zr content materials, the U-5Fs material.« less

  4. Virulence factors and resistance to antimicrobials in Listeria monocytogenes serotype 1/2c isolated from food.

    PubMed

    Gelbíčová, T; Pantůček, R; Karpíšková, R

    2016-08-01

    The aim of this study was to assess the potential risk posed to the human population by the presence of Listeria monocytogenes serotype 1/2c in food based on the characterization of virulence factors of Listeria involved in the invasion of host cells and sensitivity to antimicrobial agents. In addition to sequencing of the inlA and inlB genes, the presence of genes lapB, aut, fbpA, ami, vip and llsX was tested. A premature stop codon (PMSC) in the inlA gene was detected in all tested strains of serotype 1/2c and, concurrently, two novel PMSC mutation types were identified. However, neither PMSC in the inlB gene nor deletion of the lapB, aut, fbpA, ami and vip genes were found in any of the strains. The presence of the llsX gene was not confirmed. Even though all L. monocytogenes strains showed sensitivity to the tested antimicrobials on the basis of their phenotype, sequencing revealed the presence of IS1542 insertion in the inlA gene, indicating the possibility of sharing of mobile genetic elements associated with antimicrobial resistance among strains. Other than the presence of PMSCs in the inlA gene, no PMSC in inlB or deletion of other factors linked to the invasiveness of listeria were detected. Tested strains showed sensitivity to antibiotics used in the therapy of listeriosis. Strains of L. monocytogenes serotype 1/2c typically carry a PMSC in the inlA gene, but these strains still represent a potential threat to public health. The possibility of transfer of IS1542, associated with resistance to vancomycin, between enterococci and Listeria spp. was revealed. © 2016 The Society for Applied Microbiology.

  5. Diagnostic and Prognostic Models for Generator Step-Up Transformers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vivek Agarwal; Nancy J. Lybeck; Binh T. Pham

    In 2014, the online monitoring (OLM) of active components project under the Light Water Reactor Sustainability program at Idaho National Laboratory (INL) focused on diagnostic and prognostic capabilities for generator step-up transformers. INL worked with subject matter experts from the Electric Power Research Institute (EPRI) to augment and revise the GSU fault signatures previously implemented in the Electric Power Research Institute’s (EPRI’s) Fleet-Wide Prognostic and Health Management (FW-PHM) Suite software. Two prognostic models were identified and implemented for GSUs in the FW-PHM Suite software. INL and EPRI demonstrated the use of prognostic capabilities for GSUs. The complete set of faultmore » signatures developed for GSUs in the Asset Fault Signature Database of the FW-PHM Suite for GSUs is presented in this report. Two prognostic models are described for paper insulation: the Chendong model for degree of polymerization, and an IEEE model that uses a loading profile to calculates life consumption based on hot spot winding temperatures. Both models are life consumption models, which are examples of type II prognostic models. Use of the models in the FW-PHM Suite was successfully demonstrated at the 2014 August Utility Working Group Meeting, Idaho Falls, Idaho, to representatives from different utilities, EPRI, and the Halden Research Project.« less

  6. Characterization of LWRS Hybrid SiC-CMC-Zircaloy-4 Fuel Cladding after Gamma Irradiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Isabella J van Rooyen

    2012-09-01

    The purpose of the gamma irradiation tests conducted at the Idaho National Laboratory (INL) was to obtain a better understanding of chemical interactions and potential changes in microstructural properties of a mock-up hybrid nuclear fuel cladding rodlet design (unfueled) in a simulated PWR water environment under irradiation conditions. The hybrid fuel rodlet design is being investigated under the Light Water Reactor Sustainability (LWRS) program for further development and testing of one of the possible advanced LWR nuclear fuel cladding designs. The gamma irradiation tests were performed in preparation for neutron irradiation tests planned for a silicon carbide (SiC) ceramic matrixmore » composite (CMC) zircaloy-4 (Zr-4) hybrid fuel rodlet that may be tested in the INL Advanced Test Reactor (ATR) if the design is selected for further development and testing« less

  7. Secure Retrieval of FFTF Testing, Design, and Operating Information

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Butner, R. Scott; Wootan, David W.; Omberg, Ronald P.

    One of the goals of the Advanced Fuel Cycle Initiative (AFCI) is to preserve the knowledge that has been gained in the United States on Liquid Metal Reactors (LMR). In addition, preserving LMR information and knowledge is part of a larger international collaborative activity conducted under the auspices of the International Atomic Energy Agency (IAEA). A similar program is being conducted for EBR-II at the Idaho Nuclear Laboratory (INL) and international programs are also in progress. Knowledge preservation at the FFTF is focused on the areas of design, construction, startup, and operation of the reactor. As the primary function ofmore » the FFTF was testing, the focus is also on preserving information obtained from irradiation testing of fuels and materials. This information will be invaluable when, at a later date, international decisions are made to pursue new LMRs. In the interim, this information may be of potential use for international exchanges with other LMR programs around the world. At least as important in the United States, which is emphasizing large-scale computer simulation and modeling, this information provides the basis for creating benchmarks for validating and testing these large scale computer programs. Although the preservation activity with respect to FFTF information as discussed below is still underway, the team of authors above is currently retrieving and providing experimental and design information to the LMR modeling and simulation efforts for use in validating their computer models. On the Hanford Site, the FFTF reactor plant is one of the facilities intended for decontamination and decommissioning consistent with the cleanup mission on this site. The reactor facility has been deactivated and is being maintained in a cold and dark minimal surveillance and maintenance mode until final decommissioning is pursued. In order to ensure protection of information at risk, the program to date has focused on sequestering and secure retrieval. Accomplishments include secure retrieval of: more than 400 boxes of FFTF information, several hundred microfilm reels including Clinch River Breeder Reactor (CRBR) information, and 40 boxes of information on the Fuels and Materials Examination Facility (FMEF). All information preserved to date is now being stored and categorized consistent with the IAEA international standardized taxonomy. Earlier information largely related to irradiation testing is likewise being categorized. The fuel test results information exists in several different formats depending upon the final stage of the test evaluation. In some cases there is information from both non-destructive and destructive examination while in other cases only non-destructive results are available. Non-destructive information would include disassembly records, dimensional profilometry, gamma spectrometry, and neutron radiography. Information from destructive examinations would include fission gas analysis, metallography, and photomicrographs. Archiving of FFTF data, including both the reactor plant and the fuel test information, is being performed in coordination with other data archiving efforts underway under the aegis of the AFCI program. In addition to the FFTF efforts, archiving of data from the EBR-II reactor is being carried out by INL. All material at risk associated with FFTF documentation has been secured in a timely manner consistent with the stated plan. This documentation is now being categorized consistent with internationally agreed upon IAEA standards. Documents are being converted to electronic format for transfer to a large searchable electronic database being developed by INL. In addition, selected FFTF information is being used to generate test cases for large-scale simulation modeling efforts and for providing Design Data Need (DDN) packages as requested by the AFCI program.« less

  8. Experimental Fuels Facility Re-categorization Based on Facility Segmentation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reiss, Troy P.; Andrus, Jason

    The Experimental Fuels Facility (EFF) (MFC-794) at the Materials and Fuels Complex (MFC) located on the Idaho National Laboratory (INL) Site was originally constructed to provide controlled-access, indoor storage for radiological contaminated equipment. Use of the facility was expanded to provide a controlled environment for repairing contaminated equipment and characterizing, repackaging, and treating waste. The EFF facility is also used for research and development services, including fuel fabrication. EFF was originally categorized as a LTHC-3 radiological facility based on facility operations and facility radiological inventories. Newly planned program activities identified the need to receive quantities of fissionable materials in excessmore » of the single parameter subcritical limit in ANSI/ANS-8.1, “Nuclear Criticality Safety in Operations with Fissionable Materials Outside Reactors” (identified as “criticality list” quantities in DOE-STD-1027-92, “Hazard Categorization and Accident Analysis Techniques for Compliance with DOE Order 5480.23, Nuclear Safety Analysis Reports,” Attachment 1, Table A.1). Since the proposed inventory of fissionable materials inside EFF may be greater than the single parameter sub-critical limit of 700 g of U-235 equivalent, the initial re-categorization is Hazard Category (HC) 2 based upon a potential criticality hazard. This paper details the facility hazard categorization performed for the EFF. The categorization was necessary to determine (a) the need for further safety analysis in accordance with LWP-10802, “INL Facility Categorization,” and (b) compliance with 10 Code of Federal Regulations (CFR) 830, Subpart B, “Safety Basis Requirements.” Based on the segmentation argument presented in this paper, the final hazard categorization for the facility is LTHC-3. Department of Energy Idaho (DOE-ID) approval of the final hazard categorization determined by this hazard assessment document (HAD) was required per the DOE-ID Supplemental Guidance for DOE-STD-1027-92 based on the proposed downgrade of the initial facility categorization of Hazard Category 2.« less

  9. GW domains of the Listeria monocytogenes invasion protein InlB are SH3-like and mediate binding to host ligands

    PubMed Central

    Marino, Michael; Banerjee, Manidipa; Jonquières, Renaud; Cossart, Pascale; Ghosh, Partho

    2002-01-01

    InlB, a surface-localized protein of Listeria monocytogenes, induces phagocytosis in non-phagocytic mammalian cells by activating Met, a receptor tyrosine kinase. InlB also binds glycosaminoglycans and the protein gC1q-R, two additional host ligands implicated in invasion. We present the structure of InlB, revealing a highly elongated molecule with leucine-rich repeats that bind Met at one end, and GW domains that dissociably bind the bacterial surface at the other. Surprisingly, the GW domains are seen to resemble SH3 domains. Despite this, GW domains are unlikely to act as functional mimics of SH3 domains since their potential proline-binding sites are blocked or destroyed. However, we do show that the GW domains, in addition to binding glycosaminoglycans, bind gC1q-R specifically, and that this binding requires release of InlB from the bacterial surface. Dissociable attachment to the bacterial surface via the GW domains may be responsible for restricting Met activation to a small, localized area of the host cell and for coupling InlB-induced host membrane dynamics with bacterial proximity during invasion. PMID:12411480

  10. Conversion from film to image plates for transfer method neutron radiography of nuclear fuel

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Craft, Aaron E.; Papaioannou, Glen C.; Chichester, David L.

    This paper summarizes efforts to characterize and qualify a computed radiography (CR) system for neutron radiography of irradiated nuclear fuel at Idaho National Laboratory (INL). INL has multiple programs that are actively developing, testing, and evaluating new nuclear fuels. Irradiated fuel experiments are subjected to a number of sequential post-irradiation examination techniques that provide insight into the overall behavior and performance of the fuel. One of the first and most important of these exams is neutron radiography, which provides more comprehensive information about the internal condition of irradiated nuclear fuel than any other non-destructive technique to date. Results from neutronmore » radiography are often the driver for subsequent examinations of the PIE program. Features of interest that can be evaluated using neutron radiography include irradiation-induced swelling, isotopic and fuel-fragment redistribution, plate deformations, and fuel fracturing. The NRAD currently uses the foil-film transfer technique with film for imaging fuel. INL is pursuing multiple efforts to advance its neutron imaging capabilities for evaluating irradiated fuel and other applications, including conversion from film to CR image plates. Neutron CR is the current state-of-the-art for neutron imaging of highly-radioactive objects. Initial neutron radiographs of various types of nuclear fuel indicate that radiographs can be obtained of comparable image quality currently obtained using film. This paper provides neutron radiographs of representative irradiated fuel pins along with neutron radiographs of standards that informed the qualification of the neutron CR system for routine use. Additionally, this paper includes evaluations of some of the CR scanner parameters and their effects on image quality.« less

  11. FAST CHOPPER BUILDING, TRA665, INTERIOR. LOWER (DETECTOR) LEVEL. NOTE BRICKEDIN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FAST CHOPPER BUILDING, TRA-665, INTERIOR. LOWER (DETECTOR) LEVEL. NOTE BRICKED-IN WINDOW ON MTR SIDE. USED FOR STORAGE OF LEAD BRICKS AFTER EXPERIMENTAL NEUTRON INSTRUMENTS WERE REMOVED. SIGN SAYS "IN-PROCESS LEAD SOURCE STORAGE." INL NEGATIVE NO. HD-42-2. Mike Crane, Photographer, 3/2004 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  12. Strategy for the Identification of an INL Comprehensive Utility Corridor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    John Reisenauer

    2011-05-01

    This report documents the strategy developed to identify a comprehensive utility corridor (CUC) on the Idaho National Laboratory (INL) Site. The strategy established the process for which the Campus Development Office will evaluate land management issues. It is a process that uses geographical information system geospatial technology to layer critical INL mission information in a way that thorough evaluations can be conducted and strategies developed. The objective of the CUC Project was to develop a process that could be implemented to identify potential utility corridor options for consideration. The process had to take into account all the missions occurring onmore » the INL and other land-related issues. The process for developing a CUC strategy consists of the following four basic elements using geographical information system capabilities: 1. Development of an INL base layer map; this base layer map geospatially references all stationary geographical features on INL and sitewide information. 2. Development of current and future mission land-use need maps; this involved working with each directorate to identify current mission land use needs and future land use needs that project 30 years into the future. 3. Development of restricted and potential constraint maps; this included geospatially mapping areas such as wells, contaminated areas, firing ranges, cultural areas, ecological areas, hunting areas, easement, and grazing areas. 4. Development of state highway and power line rights of way map; this included geospatially mapping rights-of-way along existing state highways and power lines running through the INL that support INL operations. It was determined after completing and evaluating the geospatial information that the area with the least impact to INL missions was around the perimeter of the INL Site. Option 1, in this document, identifies this perimeter; however, it does not mean the entire perimeter is viable. Many places along the perimeter corridor cannot be used or are not economically viable. Specific detailed studies will need to be conducted on a case-by-case basis to clearly identify which sections along the perimeter can and cannot be used. Option 2, in this document, identifies areas along existing highways that could be a viable option. However, discussions would have to take place with the State of Idaho to use their easement as part of the corridor and mission impact would need to be evaluated if a specific request was made to the Department of Energy, Idaho Operations Office. Option 3, in this document, is a combination of Options 1 and 2. This option provides the most flexibility to minimize impacts to INL missions. As with the other two options, discussions and agreements with the State of Idaho would be needed and any specific route would need to be thoroughly evaluated for impact, implementation, and operability beyond just a strategy.« less

  13. Idaho National Laboratory 2015-2023 Ten-Year Site Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sheryl Morton; Elizabeth Connell; Bill Buyers

    2013-09-01

    This Idaho National Laboratory (INL) Ten-Year Site Plan (TYSP) describes the strategy for accomplishing the long-term objective of sustaining the INL infrastructure to meet the Department of Energy Office of Nuclear Energy (DOE-NE) mission: to promote nuclear power as a resource capable of making major contributions in meeting the nation’s energy supply, environmental and energy security needs. This TYSP provides the strategy for INL to accomplish its mission by: (1) linking R&D mission goals to core capabilities and infrastructure requirements; (2) establishing a ten-year end-state vision for INL facility complexes; (3) identifying and prioritizing infrastructure needs and capability gaps; (4)more » establishing maintenance and repair strategies that allow for sustainment of mission-critical (MC) facilities; and (5) applying sustainability principles to each decision and action. The TYSP serves as the infrastructure-planning baseline for INL; and, though budget formulation documents are informed by the TYSP, it is not itself a budget document.« less

  14. Matched Index of Refraction Flow Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mcllroy, Hugh

    What's 27 feet long, 10 feet tall and full of mineral oil (3000 gallons' worth)? If you said INL's Matched Index of Refraction facility, give yourself a gold star. Scientists use computers to model the inner workings of nuclear reactors, and MIR helps validate those models. INL's Hugh McIlroy explains in this video. You can learn more about INL energy research at the lab's facebook site http://www.facebook.com/idahonationallaboratory.

  15. Matched Index of Refraction Flow Facility

    ScienceCinema

    Mcllroy, Hugh

    2018-01-08

    What's 27 feet long, 10 feet tall and full of mineral oil (3000 gallons' worth)? If you said INL's Matched Index of Refraction facility, give yourself a gold star. Scientists use computers to model the inner workings of nuclear reactors, and MIR helps validate those models. INL's Hugh McIlroy explains in this video. You can learn more about INL energy research at the lab's facebook site http://www.facebook.com/idahonationallaboratory.

  16. Exploitation of host cell cytoskeleton and signalling during Listeria monocytogenes entry into mammalian cells.

    PubMed

    Pizarro-Cerdá, Javier; Sousa, Sandra; Cossart, Pascale

    2004-02-01

    Deciphering how Listeria monocytogenes exploits the host cell machinery to invade mammalian cells during infection is a key issue for the understanding how this food-borne pathogen causes a pleiotropic disease ranging from gastro-enteritis to meningitis and abortions. Using multidisciplinary approaches, essentially combining bacterial genetics and cell biology, we have identified two bacterial proteins critical for entry into target cells, InlA and InlB. Their cellular ligands have been also identified: InlA interacts with the adhesion molecule E-cadherin, while InlB interacts with the receptor for the globular head of the complement factor C1q (gC1q-R), with the hepatocyte growth factor receptor (c-Met) and with glycosaminoglycans (including heparan sulphate). The dynamic interaction between these cellular receptors and the actin cytoskeleton is currently under investigation. Several intracellular molecules have been recognized as key effectors for Listeria entry into target cells, including catenins (implicated in the connection of E-cadherin to actin) and the actin depolymerising factor/cofilin (involved in the rearrangement of the cytoskeleton in the InlB-dependent internalisation pathway). At the organism level, species specificity has been discovered concerning the interaction between InlA and E-cadherin, leading to the generation of transgenic mice expressing the human E-cadherin, in which the critical role of InlA in the crossing of the intestinal barrier has been clearly determined. Listeria appears as an instrumental model for addressing critical questions concerning both the complex process of bacterial pathogenesis and also fundamental molecular processes, such as phagocytosis.

  17. Exploitation of host cell cytoskeleton and signalling during Listeria monocytogenes entry into mammalian cells.

    PubMed

    Pizarro-Cerdá, Javier; Sousa, Sandra; Cossart, Pascale

    2004-06-01

    Deciphering how Listeria monocytogenes exploits the host cell machinery to invade mammalian cells during infection isa key issue for the understanding how this food-borne pathogen causes a pleiotropic disease ranging from gastro-enteritis to meningitis and abortions. Using multidisciplinary approaches, essentially combining bacterial genetics and cell biology, we have identified two bacterial proteins critical for entry into target cells, InlA and InlB. Their cellular ligands have been also identified: InlA interacts with the adhesion molecule E-cadherin, while InlB interacts with the receptor for the globular head of the complement factor Clq (gClq-R), with the hepatocyte growth factor receptor (c-Met) and with glycosaminoglycans(including heparan sulphate). The dynamic interaction between these cellular receptors and the actin cytoskeleton is currently under investigation. Several intracellular molecules have been recognized as key effectors for Listeria entry into target cells,including catenins (implicated in the connection of E-cadherin to actin) and the actin depolymerising factor/cofilin (involved in the rearrangement of the cytoskeleton in the InlB-dependent internalisation pathway). At the organism level, species specificity has been discovered concerning the interaction between InlA and E-cadherin, leading to the generation of transgenic mice expressing the human E-cadherin, in which the critical role of InlA in the crossing of the intestinal barrier has been clearly determined. Listeria appears as an instrumental model for addressing critical questions concerning both the complex process of bacterial pathogenesis and also fundamental molecular processes, such as phagocytosis.

  18. Light Water Reactor Sustainability Program FY13 Status Update for EPRI - RISMC Collaboration

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, Curtis

    2013-09-01

    The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway research and development (R&D) is to support plant decisions for risk-informed margins management with the aim to improve economics, reliability, and sustain safety of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced "RISMC toolkit" that enables more accurate representation of NPP safety margin. In order to carry out the R&D needed for the Pathway, the Idaho Nationalmore » Laboratory (INL) is collaborating with the Electric Power Research Institute (EPRI) in order to focus on applications of interest to the U.S. nuclear power industry. This report documents the collaboration activities performed between INL and EPRI during FY2013.« less

  19. RELAP-7 Software Verification and Validation Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, Curtis L.; Choi, Yong-Joon; Zou, Ling

    This INL plan comprehensively describes the software for RELAP-7 and documents the software, interface, and software design requirements for the application. The plan also describes the testing-based software verification and validation (SV&V) process—a set of specially designed software models used to test RELAP-7. The RELAP-7 (Reactor Excursion and Leak Analysis Program) code is a nuclear reactor system safety analysis code being developed at Idaho National Laboratory (INL). The code is based on the INL’s modern scientific software development framework – MOOSE (Multi-Physics Object-Oriented Simulation Environment). The overall design goal of RELAP-7 is to take advantage of the previous thirty yearsmore » of advancements in computer architecture, software design, numerical integration methods, and physical models. The end result will be a reactor systems analysis capability that retains and improves upon RELAP5’s capability and extends the analysis capability for all reactor system simulation scenarios.« less

  20. Medical Actinium Therapeutic Treatment

    ScienceCinema

    None

    2018-02-13

    Learn how INL researchers are increasing world supplies of Bismuth 213 to help with cancer treatments. For more information about INL research projects, visit http://www.facebook.com/idahonationallaboratory.

  1. Further investigation of surface velocity measurements for material characterization in laser shockwave experiments

    NASA Astrophysics Data System (ADS)

    Smith, James A.; Lacy, Jeffrey M.; Scott, Clark L.; Benefiel, Bradley C.; Lévesque, Daniel; Monchalin, Jean-Pierre; Lord, Martin

    2018-04-01

    As part of the U.S. High Performance Research Reactor program, a laser shock test system is being developed by the Idaho National Laboratory (INL) to characterize interface strength in innovative plate fuel for research reactors around the world. The INL has been working with National Research Council Canada (NRC) on this project for the last five years. One of the concerns is the difficulty of calibrating and standardizing the laser shock technique. A recent analytical study and testing support the use of the Hugoniot Elastic Limit (HEL) in materials as a robust and simple benchmark to compare stresses generated by different laser shock systems. Using a non-contact laser velocimeter based on a solid Fabry-Perot etalon, the systems at NRC and INL show that the back-surface velocity reached at the HEL is consistent, and independent of the laser power used. In this work, the laser velocimeter of the NRC system is tested against a fast rotating wheel to verify accuracy and determine best operating conditions. A round robin test between the two laser shock systems on plates of different aluminum alloys is presented that shows the consistent characterization of the aluminum alloys based on the HEL velocities as well as determines the bias between the systems. The effects of setup parameters on other characteristics of the back-surface velocity trace and corresponding stress wave are also discussed.

  2. Online Monitoring Technical Basis and Analysis Framework for Large Power Transformers; Interim Report for FY 2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nancy J. Lybeck; Vivek Agarwal; Binh T. Pham

    The Light Water Reactor Sustainability program at Idaho National Laboratory (INL) is actively conducting research to develop and demonstrate online monitoring (OLM) capabilities for active components in existing Nuclear Power Plants. A pilot project is currently underway to apply OLM to Generator Step-Up Transformers (GSUs) and Emergency Diesel Generators (EDGs). INL and the Electric Power Research Institute (EPRI) are working jointly to implement the pilot project. The EPRI Fleet-Wide Prognostic and Health Management (FW-PHM) Software Suite will be used to implement monitoring in conjunction with utility partners: the Shearon Harris Nuclear Generating Station (owned by Duke Energy for GSUs, andmore » Braidwood Generating Station (owned by Exelon Corporation) for EDGs. This report presents monitoring techniques, fault signatures, and diagnostic and prognostic models for GSUs. GSUs are main transformers that are directly connected to generators, stepping up the voltage from the generator output voltage to the highest transmission voltages for supplying electricity to the transmission grid. Technical experts from Shearon Harris are assisting INL and EPRI in identifying critical faults and defining fault signatures associated with each fault. The resulting diagnostic models will be implemented in the FW-PHM Software Suite and tested using data from Shearon-Harris. Parallel research on EDGs is being conducted, and will be reported in an interim report during the first quarter of fiscal year 2013.« less

  3. Blast Noise Prediction. Volume II. BNOISE 3.2 Computer Program Description and Program Listing.

    DTIC Science & Technology

    1981-03-01

    tttim itit) k cii he sCli h I Apptif 4\\1111,1C’ I Lin ~Ist I Itis is tj ’it. hi ilti Ituitph inlI N’ skiLl I ink, hi k I i e II it,~ 11it I Mi...to which the point (XMIN,YMIN) will correspond SCLE Card cc 1 SCLI - PS( A L Format (A4,2X,G8.3) where. PSCALF (col 7-14t is the plotter scale factor

  4. Differential expression of Listeria monocytogenes virulence genes in mammalian host cells.

    PubMed

    Bubert, A; Sokolovic, Z; Chun, S K; Papatheodorou, L; Simm, A; Goebel, W

    1999-03-01

    We have used RT-PCR and GFP-mediated fluorescence to analyse the regulation of PrfA-dependent virulence genes of Listeria monocytogenes during proliferation in mammalian host cells. Our data show that most of the PrfA-regulated virulence genes are more efficiently expressed, as measured by transcript levels, when L. monocytogenes is grown in macrophages and macrophage-like cells rather than in epithelial cells, hepatocytes or endothelial cells. The promoters for hly and plcA are predominantly activated within the phagosomal compartment, while those for actA and inlC are predominantly activated in the host cell cytosol. Expression of actA and plcB precedes that of inlC after infection of epithelial cells and macrophages. Little transcription of inlA or inlB is observed in epithelial cells and there is only slightly more in macrophages. In both cell types the level of transcription of the inlAB operon is lower than is seen under extracellular growth conditions in rich media, which is compatible with the assumption that InlA and InlB are not required during intracellular growth of the bacteria. Activation of the PrfA-independent iap promoter is also low during intracellular growth, although the gene product (p60) is required for cell viability. The levels of the PrfA-dependent virulence gene transcripts do not correlate with the amount of prfA transcript present, which is low under all intracellular conditions analysed, suggesting that the prfA transcript is either highly unstable in bacteria that are growing intracellularly, or that the small amount of PrfA produced is highly activated by additional component(s).

  5. Different foveal schisis patterns in each retinal layer in eyes with hereditary juvenile retinoschisis evaluated by en-face optical coherence tomography.

    PubMed

    Yoshida-Uemura, Tomoyo; Katagiri, Satoshi; Yokoi, Tadashi; Nishina, Sachiko; Azuma, Noriyuki

    2017-04-01

    To analyze the structures of schisis in eyes with hereditary juvenile retinoschisis using en-face optical coherence tomography (OCT) imaging. In this retrospective observational study, we reviewed the medical records of patients with hereditary juvenile retinoschisis who underwent comprehensive ophthalmic examinations including swept-source OCT. OCT images were obtained from 16 eyes of nine boys (mean age ± standard deviation, 10.6 ± 4.0 years). The horizontal OCT images at the fovea showed inner nuclear layer (INL) schisis in one eye (6.3 %), ganglion cell layer (GCL) and INL schisis in 12 eyes (75.0 %), INL and outer plexiform layer (OPL) schisis in two eyes (12.5 %), and GCL, INL, and OPL schisis in one eye (6.3 %). En-face OCT images showed characteristic schisis patterns in each retinal layer, which were represented by multiple hyporeflective holes in the parafoveal region in the GCL, a spoke-like pattern in the foveal region, a reticular pattern in the parafoveal region in the INL, and multiple hyporeflective polygonal cavities with partitions in the OPL. Our results using en-face OCT imaging clarified different patterns of schisis formation among the GCL, INL, and OPL, which lead to further recognition of structure in hereditary juvenile retinoschisis.

  6. Climate Change Vulnerability Assessment for Idaho National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Christopher P. Ischay; Ernest L. Fossum; Polly C. Buotte

    2014-10-01

    The University of Idaho (UI) was asked to participate in the development of a climate change vulnerability assessment for Idaho National Laboratory (INL). This report describes the outcome of that assessment. The climate change happening now, due in large part to human activities, is expected to continue in the future. UI and INL used a common framework for assessing vulnerability that considers exposure (future climate change), sensitivity (system or component responses to climate), impact (exposure combined with sensitivity), and adaptive capacity (capability of INL to modify operations to minimize climate change impacts) to assess vulnerability. Analyses of climate change (exposure)more » revealed that warming that is ongoing at INL will continue in the coming decades, with increased warming in later decades and under scenarios of greater greenhouse gas emissions. Projections of precipitation are more uncertain, with multi model means exhibiting somewhat wetter conditions and more wet days per year. Additional impacts relevant to INL include estimates of more burned area and increased evaporation and transpiration, leading to reduced soil moisture and plant growth.« less

  7. Idaho Science, Technology, Engineering and Mathematics Overview

    ScienceCinema

    None

    2017-12-09

    Idaho National Laboratory has been instrumental in establishing the Idaho Science, Technology, Engineering and Mathematics initiative -- i-STEM, which brings together industry, educators, government and other partners to provide K-12 teachers with support, materials and opportunities to improve STEM instruction and increase student interest in technical careers. You can learn more about INL's education programs at http://www.facebook.com/idahonationallaboratory.

  8. Idaho Science, Technology, Engineering and Mathematics Overview

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hampton, Brandon; Shoushtarian, Joannah; Ledoux, P

    2011-02-11

    Idaho National Laboratory has been instrumental in establishing the Idaho Science, Technology, Engineering and Mathematics initiative -- i-STEM, which brings together industry, educators, government and other partners to provide K-12 teachers with support, materials and opportunities to improve STEM instruction and increase student interest in technical careers. You can learn more about INL's education programs at http://www.facebook.com/idahonationallaboratory.

  9. Using the Human Systems Simulation Laboratory at Idaho National Laboratory for Safety Focused Research

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Joe, Jeffrey .C; Boring, Ronald L.

    Under the United States (U.S.) Department of Energy (DOE) Light Water Reactor Sustainability (LWRS) program, researchers at Idaho National Laboratory (INL) have been using the Human Systems Simulation Laboratory (HSSL) to conduct critical safety focused Human Factors research and development (R&D) for the nuclear industry. The LWRS program has the overall objective to develop the scientific basis to extend existing nuclear power plant (NPP) operating life beyond the current 60-year licensing period and to ensure their long-term reliability, productivity, safety, and security. One focus area for LWRS is the NPP main control room (MCR), because many of the instrumentation andmore » control (I&C) system technologies installed in the MCR, while highly reliable and safe, are now difficult to replace and are therefore limiting the operating life of the NPP. This paper describes how INL researchers use the HSSL to conduct Human Factors R&D on modernizing or upgrading these I&C systems in a step-wise manner, and how the HSSL has addressed a significant gap in how to upgrade systems and technologies that are built to last, and therefore require careful integration of analog and new advanced digital technologies.« less

  10. Idaho Explosive Detection System

    ScienceCinema

    Klinger, Jeff

    2018-05-23

    Learn how INL researchers are making the world safer by developing an explosives detection system that can inspect cargo. For more information about INL security research, visit http://www.facebook.com/idahonationallaboratory

  11. MTR,TRA603. EXPERIMENTERS' SPACE ALLOCATIONS IN BASEMENT AS OF 1963. SHIELDED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR,TRA-603. EXPERIMENTERS' SPACE ALLOCATIONS IN BASEMENT AS OF 1963. SHIELDED CUBICLES WERE IDENTIFIED BY SPONSORING LABORATORY AND ITS TEST HOLE NUMBER IN THE REACTOR, IE, "KAPL HB-1" SIGNIFIED KNOLLS ATOMIC POWER LABORATORY, HORIZONTAL BEAM NO. 1. "WAPD" WAS WESTINGHOUSE ATOMIC POWER DIVISION. CATCH TANKS AND SAMPLE STATIONS FOR TEST LOOPS WERE ASSOCIATED WITH THESE CUBICLES. NOTE DESKS, STORAGE CABINETS, SWITCH GEAR, INSTRUMENT PANELS. PHILLIPS PETROLEUM COMPANY MTR-E-5205, 4/1963. INL INDEX NO. 531-0603-00-706-009757, REV. 5. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  12. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carvo, Alan E.

    Between the mid-1970s and the mid-1980s Sandia National Laboratory constructed eleven experimental assemblies to simulate debris beds formed in a sodium-cooled fast breeder reactor. All but one of the assemblies were irradiated. The experimental assemblies were transferred to the Idaho National Laboratory (INL) in 2007 and 2008 for storage, dismantlement, recovery of the uranium for reuse in the nuclear fuel cycle, and disposal of unneeded materials. This paper addresses the effort to dismantle the assemblies down to the primary containment vessel and repackage them for temporary storage until such time as equipment necessary for sodium separation is in place.

  13. INL Autonomous Navigation System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    2005-03-30

    The INL Autonomous Navigation System provides instructions for autonomously navigating a robot. The system permits high-speed autonomous navigation including obstacle avoidance, waypoing navigation and path planning in both indoor and outdoor environments.

  14. Post-wildfire wind erosion in and around the Idaho National Laboratory Site

    USGS Publications Warehouse

    Germino, Matthew J.

    2012-01-01

    Wind erosion following large wildfires on and around the INL Site is a recurrent threat to human health and safety, DOE operations and trafficability, and ecological and hydrological condition of the INL Site and down-wind landscapes. Causes and consequences of wind erosion are mainly known from warm deserts (e.g., Southwest U.S.), dunefields, and croplands, and some but not all findings are transferable to the cold desert environments such as where the INL Site lies.

  15. Tracking Listeria monocytogenes contamination and virulence-associated characteristics in the ready-to-eat meat-based food products industry according to the hygiene level.

    PubMed

    Henriques, A R; Gama, L T; Fraqueza, M J

    2017-02-02

    Listeria monocytogenes isolates collected from final products and food contact surfaces of 10 ready-to-eat meat-based food products (RTEMP) producing industries were analyzed to relate their virulence-associated characteristics and genetic profiles with the hygiene assessment of those industries. Together with sample collection, an audit was performed to evaluate the implemented food safety management system and to investigate the specific audit requisites more associated to the occurrence of those L. monocytogenes serogroups frequently related with human disease. L. monocytogenes was present in 18% of the samples. The isolates (n=62) were serogrouped and detection of virulence-associated genes inlA, inlB, inlC and inlJ, and also plcA, hlyA, actA and iap was done by multiplex PCR. After this initial characterization, selected isolates (n=31) were submitted to antibiotic resistance testing by the disk diffusion method for the currently most used human and veterinary antibiotics and resistance was low. These isolates were also subtyped by pulsed-field gel electrophoresis. Genotyping and serogrouping of L. monocytogenes isolates revealed a genetically diverse population. Our data indicate that contamination of final products does not seem to be uniquely related to the sampled food surfaces. The occurrence of those L. monocytogenes serogroups more commonly associated with human disease in industries with a high hygienic audit classification could be the result of a previous identification of the pathogen, with an enforcement of the hygiene program without recognizing the real source of contamination. This reinforces the importance of a conjoined diagnosis using audit data and microbiological testing. Food safety management systems of those industries need improvement, particularly in cleaning and sanitizing operations, analytical control, preventive maintenance, personal hygiene and root cause analysis. Copyright © 2016. Published by Elsevier B.V.

  16. Solar Nanoantennas

    ScienceCinema

    None

    2018-05-16

    Bang Goes the Theory: See how this BBC TV show described INL research to one day make electricity from ambient heat. You can learn more about INL's energy research projects at http://www.facebook.com/idahonationallaboratory.

  17. Instrumentation, Control, and Intelligent Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2005-09-01

    Abundant and affordable energy is required for U.S. economic stability and national security. Advanced nuclear power plants offer the best near-term potential to generate abundant, affordable, and sustainable electricity and hydrogen without appreciable generation of greenhouse gases. To that end, Idaho National Laboratory (INL) has been charged with leading the revitalization of nuclear power in the U.S. The INL vision is to become the preeminent nuclear energy laboratory with synergistic, world-class, multi-program capabilities and partnerships by 2015. The vision focuses on four essential destinations: (1) Be the preeminent internationally-recognized nuclear energy research, development, and demonstration laboratory; (2) Be a majormore » center for national security technology development and demonstration; (3) Be a multi-program national laboratory with world-class capabilities; (4) Foster academic, industry, government, and international collaborations to produce the needed investment, programs, and expertise. Crucial to that effort is the inclusion of research in advanced instrumentation, control, and intelligent systems (ICIS) for use in current and advanced power and energy security systems to enable increased performance, reliability, security, and safety. For nuclear energy plants, ICIS will extend the lifetime of power plant systems, increase performance and power output, and ensure reliable operation within the system's safety margin; for national security applications, ICIS will enable increased protection of our nation's critical infrastructure. In general, ICIS will cost-effectively increase performance for all energy security systems.« less

  18. INL@Work Cyber Security

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chaffin, May

    May Chaffin is one of many Idaho National Laboratory researchers who are helping secure the nation's critical infrastructure from cyber attacks.Lots more content like this is available at INL's facebook page http://www.facebook.com/idahonationallaboratory.

  19. Managing Critical Infrastructures C.I.M. Suite

    ScienceCinema

    Dudenhoeffer, Donald

    2018-05-23

    See how a new software package developed by INL researchers could help protect infrastructure during natural disasters, terrorist attacks and electrical outages. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  20. INL@Work Firefighter

    ScienceCinema

    Baron, Wendy

    2018-01-15

    Did you know INL has its own firefighting team? Its members help protect our remote 890-square-mile site from range fires and other incidents. Meet firefighter Wendy Baron, who was recently named Idaho's firefighter of the year.

  1. INL@Work Firefighter

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baron, Wendy

    2011-01-01

    Did you know INL has its own firefighting team? Its members help protect our remote 890-square-mile site from range fires and other incidents. Meet firefighter Wendy Baron, who was recently named Idaho's firefighter of the year.

  2. Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis.

    PubMed

    Disson, Olivier; Grayo, Solène; Huillet, Eugénie; Nikitas, Georgios; Langa-Vives, Francina; Dussurget, Olivier; Ragon, Marie; Le Monnier, Alban; Babinet, Charles; Cossart, Pascale; Lecuit, Marc

    2008-10-23

    The ability to cross host barriers is an essential virulence determinant of invasive microbial pathogens. Listeria monocytogenes is a model microorganism that crosses human intestinal and placental barriers, and causes severe maternofetal infections by an unknown mechanism. Several studies have helped to characterize the bacterial invasion proteins InlA and InlB. However, their respective species specificity has complicated investigations on their in vivo role. Here we describe two novel and complementary animal models for human listeriosis: the gerbil, a natural host for L. monocytogenes, and a knock-in mouse line ubiquitously expressing humanized E-cadherin. Using these two models, we uncover the essential and interdependent roles of InlA and InlB in fetoplacental listeriosis, and thereby decipher the molecular mechanism underlying the ability of a microbe to target and cross the placental barrier.

  3. MicroSight Optics

    ScienceCinema

    None

    2018-05-16

    MicroSight is an innovative gunsight technology that allows a marksman's eye to focus on both the front gunsight and the intended target. The MicroSight improves both firearm safety and performance by imaging two objects at different focal distances. The MicroSight was developed at Idaho National Laboratory, and has been licensed by Apollo Optical Systems. You can learn more about INL's research programs at http://www.facebook.com/idahonationallaboratory.

  4. NEAMS FPL M2 Milestone Report: Development of a UO₂ Grain Size Model using Multicale Modeling and Simulation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tonks, Michael R; Zhang, Yongfeng; Bai, Xianming

    2014-06-01

    This report summarizes development work funded by the Nuclear Energy Advanced Modeling Simulation program's Fuels Product Line (FPL) to develop a mechanistic model for the average grain size in UO₂ fuel. The model is developed using a multiscale modeling and simulation approach involving atomistic simulations, as well as mesoscale simulations using INL's MARMOT code.

  5. A Charge-Coupled Device (CCD) Memory for Navy C3 Systems

    DTIC Science & Technology

    1976-07-30

    CONTRACT OR GRANT mumUER(a) __ _ _ IT /Ii,/skiA ~ f I. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK Naval...kcy A1is al)oed inl soice ronCilites to allow tilc user to rely pie th Lilst cha~r.,.oer. Ini I1)11 M( )lDl-, a user is, allowed to cdit the data oin

  6. MicroSight Optics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2010-01-01

    MicroSight is an innovative gunsight technology that allows a marksman's eye to focus on both the front gunsight and the intended target. The MicroSight improves both firearm safety and performance by imaging two objects at different focal distances. The MicroSight was developed at Idaho National Laboratory, and has been licensed by Apollo Optical Systems. You can learn more about INL's research programs at http://www.facebook.com/idahonationallaboratory.

  7. Treatment of Perfluorinated Alkyl Substances in Wash Water ...

    EPA Pesticide Factsheets

    Report The U.S. Environmental Protection Agency’s (EPA) National Homeland Security Research Center partnered with the Idaho National Laboratory (INL) to build the Water Security Test Bed (WSTB) at the INL test site outside of Idaho Falls, Idaho. This report summarizes the results from testing conducted to evaluate the treatment of large volumes of water containing perfluorinated alkyl substances (PFAS). This summary of conclusions and observations about the performance and implementation of adsorptive treatment of AFFF contaminated water, based on the testing performed at the INL WSTB.

  8. Idaho National Laboratory’s Analysis of ARRA-Funded Plug-in Electric Vehicle and Charging Infrastructure Projects: Final Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Francfort, Jim; Bennett, Brion; Carlson, Richard

    2015-09-01

    Battelle Energy Alliance, LLC, managing and operating contractor for the U.S. Department of Energy’s (DOE) Idaho National Laboratory (INL), is the lead laboratory for U.S. Department of Energy’s Advanced Vehicle Testing Activity (AVTA). INL’s conduct of the AVTA resulted in a significant base of knowledge and experience in the area of testing light-duty vehicles that reduced transportation-related petroleum consumption. Due to this experience, INL was tasked by DOE to develop agreements with companies that were the recipients of The American Recovery and Reinvestment Act of 2009 (ARRA) grants, that would allow INL to collect raw data from light-duty vehicles andmore » charging infrastructure. INL developed non-disclosure agreements (NDAs) with several companies and their partners that resulted in INL being able to receive raw data via server-to-server connections from the partner companies. This raw data allowed INL to independently conduct data quality checks, perform analysis, and report publicly to DOE, partners, and stakeholders, how drivers used both new vehicle technologies and the deployed charging infrastructure. The ultimate goal was not the deployment of vehicles and charging infrastructure, cut rather to create real-world laboratories of vehicles, charging infrastructure and drivers that would aid in the design of future electric drive transportation systems. The five projects that INL collected data from and their partners are: • ChargePoint America - Plug-in Electric Vehicle Charging Infrastructure Demonstration • Chrysler Ram PHEV Pickup - Vehicle Demonstration • General Motors Chevrolet Volt - Vehicle Demonstration • The EV Project - Plug-in Electric Vehicle Charging Infrastructure Demonstration • EPRI / Via Motors PHEVs – Vehicle Demonstration The document serves to benchmark the performance science involved the execution, analysis and reporting for the five above projects that provided lessons learned based on driver’s use of the vehicles and recharging decisions made. Data is reported for the use of more than 25,000 vehicles and charging units.« less

  9. INL High Performance Building Strategy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jennifer D. Morton

    High performance buildings, also known as sustainable buildings and green buildings, are resource efficient structures that minimize the impact on the environment by using less energy and water, reduce solid waste and pollutants, and limit the depletion of natural resources while also providing a thermally and visually comfortable working environment that increases productivity for building occupants. As Idaho National Laboratory (INL) becomes the nation’s premier nuclear energy research laboratory, the physical infrastructure will be established to help accomplish this mission. This infrastructure, particularly the buildings, should incorporate high performance sustainable design features in order to be environmentally responsible and reflectmore » an image of progressiveness and innovation to the public and prospective employees. Additionally, INL is a large consumer of energy that contributes to both carbon emissions and resource inefficiency. In the current climate of rising energy prices and political pressure for carbon reduction, this guide will help new construction project teams to design facilities that are sustainable and reduce energy costs, thereby reducing carbon emissions. With these concerns in mind, the recommendations described in the INL High Performance Building Strategy (previously called the INL Green Building Strategy) are intended to form the INL foundation for high performance building standards. This revised strategy incorporates the latest federal and DOE orders (Executive Order [EO] 13514, “Federal Leadership in Environmental, Energy, and Economic Performance” [2009], EO 13423, “Strengthening Federal Environmental, Energy, and Transportation Management” [2007], and DOE Order 430.2B, “Departmental Energy, Renewable Energy, and Transportation Management” [2008]), the latest guidelines, trends, and observations in high performance building construction, and the latest changes to the Leadership in Energy and Environmental Design (LEED®) Green Building Rating System (LEED 2009). The document employs a two-level approach for high performance building at INL. The first level identifies the requirements of the Guiding Principles for Sustainable New Construction and Major Renovations, and the second level recommends which credits should be met when LEED Gold certification is required.« less

  10. Cyber Security and Resilient Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Robert S. Anderson

    2009-07-01

    The Department of Energy (DOE) Idaho National Laboratory (INL) has become a center of excellence for critical infrastructure protection, particularly in the field of cyber security. It is one of only a few national laboratories that have enhanced the nation’s cyber security posture by performing industrial control system (ICS) vendor assessments as well as user on-site assessments. Not only are vulnerabilities discovered, but described actions for enhancing security are suggested – both on a system-specific basis and from a general perspective of identifying common weaknesses and their corresponding corrective actions. These cyber security programs have performed over 40 assessments tomore » date which have led to more robust, secure, and resilient monitoring and control systems for the US electrical grid, oil and gas, chemical, transportation, and many other sectors. In addition to cyber assessments themselves, the INL has been engaged in outreach to the ICS community through vendor forums, technical conferences, vendor user groups, and other special engagements as requested. Training programs have been created to help educate all levels of management and worker alike with an emphasis towards real everyday cyber hacking methods and techniques including typical exploits that are used. The asset owner or end user has many products available for its use created from these programs. One outstanding product is the US Department of Homeland Security (DHS) Cyber Security Procurement Language for Control Systems document that provides insight to the user when specifying a new monitoring and control system, particularly concerning security requirements. Employing some of the top cyber researchers in the nation, the INL can leverage this talent towards many applications other than critical infrastructure. Monitoring and control systems are used throughout the world to perform simple tasks such as cooking in a microwave to complex ones such as the monitoring and control of the next generation fighter jets or nuclear material safeguards systems in complex nuclear fuel cycle facilities. It is the intent of this paper to describe the cyber security programs that are currently in place, the experiences and successes achieved in industry including outreach and training, and suggestions about how other sectors and organizations can leverage this national expertise to help their monitoring and control systems become more secure.« less

  11. Engineered Zircaloy Cladding Modifications for Improved Accident Tolerance of LWR Nuclear Fuel

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Heuser, Brent; Stubbins, James; Kozlowski, Tomasz

    The DOE NEUP sponsored IRP on accident tolerant fuel (ATF) entitled Engineered Zircaloy Cladding Modifications for Improved Accident Tolerance of LWR Nuclear Fuel involved three academic institutions, Idaho National Laboratory (INL), and ATI Materials (ATI). Detailed descriptions of the work at the University of Illinois (UIUC, prime), the University of Florida (UF), the University of Michigan (UMich), and INL are included in this document as separate sections. This summary provides a synopsis of the work performed across the IRP team. Two ATF solution pathways were initially proposed, coatings on monolithic Zr-based LWR cladding material and selfhealing modifications of Zr-based alloys.more » The coating pathway was extensively investigated, both experimentally and in computations. Experimental activities related to ATF coatings were centered at UIUC, UF, and UMich and involved coating development and testing, and ion irradiation. Neutronic and thermal hydraulic aspects of ATF coatings were the focus of computational work at UIUC and UMich, while materials science aspects were the focus of computational work at UF and INL. ATI provided monolithic Zircaloy 2 and 4 material and a binary Zr-Y alloy material. The selfhealing pathway was investigated with advanced computations only. Beryllium was identified as a valid self-healing additive early in this work. However, all attempts to fabricate a Zr-Be alloy failed. Several avenues of fabrication were explored. ATI ultimately declined our fabrication request over health concerns associated with Be (we note that Be was not part of the original work scope and the ATI SOW). Likewise, Ames Laboratory declined our fabrication request, citing known litigation dating to the 1980s and 1990s involving the U.S. Federal government and U.S. National Laboratory employees involving the use of Be. Materion (formerly, Brush Wellman) also declined our fabrication request, citing the difficulty in working with a highly reactive Zr and Be. International fabrication options were explored in Europe and Asia, but this proved to be impractical, if not impossible. Consequently, experimental investigation of the Zr-Be binary system was dropped and exploration binary Zr-Y binary system was initiated. The motivation behind the Zr-Y system is the known thermodynamic stability of yttria over zirconia.« less

  12. ETR ELECTRICAL BUILDING, TRA648, INTERIOR. SWITCHGEAR. INL NEGATIVE NO. 563794. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR ELECTRICAL BUILDING, TRA-648, INTERIOR. SWITCHGEAR. INL NEGATIVE NO. 56-3794. Jack L. Anderson, Photographer, 11/26/1956 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  13. ETR ELECTRICAL BUILDING, TRA648. BATTERY ROOM. INL NEGATIVE NO. 563785. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR ELECTRICAL BUILDING, TRA-648. BATTERY ROOM. INL NEGATIVE NO. 56-3785. Jack L. Anderson, Photographer, 11/26/1956 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  14. Julie D. Baker - Associate Laboratory Director | NREL

    Science.gov Websites

    her most recent role at INL, Baker has served in a variety of operations, engineering, science and role as special assistant to INL's laboratory director. During that time, Baker engaged in the full

  15. High Temperature Irradiation Resistant Thermocouple (HTIR-TC)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rempe, Joy; Condie, Keith; Knudson, Darrell

    2011-01-01

    INL researchers have created a new thermocouple that can resist high temperature and radiation. This device will improve safety and reduce costs associated with unit failures. Learn more about INL research at http://www.facebook.com/idahonationallaboratory

  16. INL Archeology Tour

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stone, Brett

    Check out this tour of the Idaho National Laboratory's archeological sites. The lab sits on 890-square miles of land and contains numerous archeological artifacts. Lots more content like this is available at INL's facebook page http://www.facebook.com/idahonationallaboratory.

  17. High Temperature Irradiation Resistant Thermocouple (HTIR-TC)

    ScienceCinema

    Rempe, Joy; Condie, Keith; Knudson, Darrell

    2018-05-16

    INL researchers have created a new thermocouple that can resist high temperature and radiation. This device will improve safety and reduce costs associated with unit failures. Learn more about INL research at http://www.facebook.com/idahonationallaboratory

  18. INL Archeology Tour

    ScienceCinema

    None

    2017-12-09

    Check out this tour of the Idaho National Laboratory's archeological sites. The lab sits on 890-square miles of land and contains numerous archeological artifacts. Lots more content like this is available at INL's facebook page http://www.facebook.com/idahonationallaboratory.

  19. PROCESS WATER BUILDING, TRA605. INSIDE A FLASH EVAPORATOR. INL NEGATIVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PROCESS WATER BUILDING, TRA-605. INSIDE A FLASH EVAPORATOR. INL NEGATIVE NO. 3323. Unknown Photographer, 9/12/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  20. Special Analysis for the Disposal of the INL Waste Associated with the Unirradiated Light Water Breeder Reactor (LWBR) Waste Stream at the Area 5 Radioactive Waste Management Site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shott, Gregory

    This special analysis (SA) evaluates whether the Idaho National Laboratory (INL) Waste Associated with the Unirradiated Light Water Breeder Reactor (LWBR) waste stream (INEL167203QR1, Revision 0) is suitable for shallow land burial (SLB) at the Area 5 Radioactive Waste Management Site (RWMS) on the Nevada National Security Site (NNSS). Disposal of the INL Waste Associated with the Unirradiated LWBR waste meets all U.S. Department of Energy (DOE) Manual DOE M 435.1-1, “Radioactive Waste Management Manual,” Chapter IV, Section P performance objectives (DOE 1999). The INL Waste Associated with the Unirradiated LWBR waste stream is recommended for acceptance with the conditionmore » that the total uranium-233 ( 233U) inventory be limited to 2.7E13 Bq (7.2E2 Ci).« less

  1. Host Serine/Threonine Kinases mTOR and Protein Kinase C-α Promote InlB-Mediated Entry of Listeria monocytogenes

    PubMed Central

    Bhalla, Manmeet; Law, Daria; Dowd, Georgina C.

    2017-01-01

    ABSTRACT The bacterial pathogen Listeria monocytogenes causes foodborne illnesses resulting in gastroenteritis, meningitis, or abortion. Listeria induces its internalization into some human cells through interaction of the bacterial surface protein InlB with the host receptor tyrosine kinase Met. InlB-dependent entry requires localized polymerization of the host actin cytoskeleton. The signal transduction pathways that act downstream of Met to regulate actin filament assembly or other processes during Listeria uptake remain incompletely characterized. Here, we demonstrate important roles for the human serine/threonine kinases mTOR and protein kinase C-α (PKC-α) in InlB-dependent entry. Experiments involving RNA interference (RNAi) indicated that two multiprotein complexes containing mTOR, mTORC1 and mTORC2, are each needed for efficient internalization of Listeria into cells of the human cell line HeLa. InlB stimulated Met-dependent phosphorylation of mTORC1 or mTORC2 substrates, demonstrating activation of both mTOR-containing complexes. RNAi studies indicated that the mTORC1 effectors 4E-BP1 and hypoxia-inducible factor 1α (HIF-1α) and the mTORC2 substrate PKC-α each control Listeria uptake. Genetic or pharmacological inhibition of PKC-α reduced the internalization of Listeria and the accumulation of actin filaments that normally accompanies InlB-mediated entry. Collectively, our results identify mTOR and PKC-α to be host factors exploited by Listeria to promote infection. PKC-α controls Listeria entry, at least in part, by regulating the actin cytoskeleton downstream of the Met receptor. PMID:28461391

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Simpson, Wayne; Borders, Tammie

    INL successfully developed a proof of concept for "Software Defined Anything" by emulating the laboratory's business applications that run on Virtual Machines. The work INL conducted demonstrates to industry on how this methodology can be used to improve security, automate and repeat processes, and improve consistency.

  3. CONSTRUCTION VIEW OF MAIN PROCESSING BUILDING (CPP601) LOOKING NORTHWEST. INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION VIEW OF MAIN PROCESSING BUILDING (CPP-601) LOOKING NORTHWEST. INL PHOTO NUMBER NRTS-51-1390. Unknown Photographer, 1/31/1951 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  4. CONSTRUCTION PROGRESS PHOTO OF REMOTE ANALYTICAL FACILITY (CPP627). INL PHOTO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO OF REMOTE ANALYTICAL FACILITY (CPP-627). INL PHOTO NUMBER NRTS-54-12124. Unknown Photographer, 9/21/1954 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  5. DETAILS OF REMOTE ANALYTICAL FACILITY (CPP627). INL DRAWING NUMBER 200062700098105071. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAILS OF REMOTE ANALYTICAL FACILITY (CPP-627). INL DRAWING NUMBER 200-0627-00-098-105071. ALTERNATE ID NUMBER 4272-14-108. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  6. CONSTRUCTION VIEW OF MAIN PROCESSING BUILDING (CPP601) LOOKING EAST. INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION VIEW OF MAIN PROCESSING BUILDING (CPP-601) LOOKING EAST. INL PHOTO NUMBER NRTS-51-1547. Unknown Photographer, 2/28/1951 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  7. FAST CHOPPER BUILDING, TRA665, INTERIOR. UPPER LEVEL. CONCRETE WALLS. INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FAST CHOPPER BUILDING, TRA-665, INTERIOR. UPPER LEVEL. CONCRETE WALLS. INL NEGATIVE NO. HD42-2. Mike Crane, Photographer, 3/2004 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  8. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Halsey, W

    This report provides a summary for FY-2008 of activities, analyses and products from the Material Transportation, Storage and Disposal (M-TSD) sub-task of Systems Analysis within the Advanced Fuel Cycle Research & Development area of the Global Nuclear Energy Partnership. The objective of this work is to evaluate near-term material management requirements for initial GNEP facilities and activities, long-term requirements for large-scale GNEP technology deployment, and alternatives and paths forward to meet these needs. For FY-08, the work expanded to include the Integrated Waste Management Strategy as well as integration with the newly formed Waste Forms Campaign. The M-TSD team wasmore » expanded with the addition of support from Savannah River National Lab (SRNL) to the existing team of Lawrence Livermore National Lab (LLNL), Argonne National Lab (ANL), Idaho National Lab (INL), Sandia National Lab (SNL) and University of Nevada - Reno (UN-R). During the first half of the year, analysis was focused on providing supporting technical analysis and documentation to support anticipated high-level decisions on program direction. A number of analyses were conducted and reports prepared as program deliverables. This work is briefly summarized in this report. Analyses provided informally to other program efforts are included in this report to provide documentation. This year-end summary was planned primarily as a compilation of activities following the anticipated programmatic decisions. These decisions were deferred beyond the end of the year, and funds were reallocated in a number of areas, thus reducing the M-TSD activities. This report summarizes the miscellaneous 'ad-hoc' work conducted during the later part of the year, such as support to the draft Programmatic Environmental Impact Statement (PEIS), and support to other program studies. Major programmatic contributions from the M-TSD team during the year included: (1) Completion of the IWMS in March 2008 as the baseline for waste management calculations for the GNEP Programmatic Environmental Impact Statement (PEIS). The IWMS represents a collaborative effort between the Systems Analysis, Waste Forms, and Separations Campaigns with contributing authors from multiple laboratories. The IWMS reference is: 'Global Nuclear Energy Partnership Integrated Waste Management Strategy, D. Gombert, INL, et al, GNEP-WAST-WAST-AI-RT-2008-000214, March 2008'. (2) As input to the IWMS and support for program decisions, an evaluation of the current regulatory framework in the U.S. pertaining to the disposal of radioactive wastes under an advanced nuclear fuel cycle was completed by ANL. This evaluation also investigated potential disposal pathways for these wastes. The entire evaluation is provided in Appendix A of this report. (3) Support was provided to the development of the GNEP Programmatic Environmental Impact Statement from INL, SNL and ANL M-TSD staff. (4) M-TSD staff prepared input for DSARR (Dynamic Systems Analysis Report for Nuclear Fuel Recycle) report. The DSARR is an INL led report to examine the time-dependent dynamics for a transition from the current open fuel cycle to either a 1-tier or 2-tier closed fuel cycle. Section 5.3 Waste Management Impacts was provided to INL for incorporation into the DSARR. (5) SNL M-TSD staff prepared a M2 milestone report 'Material Transportation, Storage and Disposal Contribution for Secretarial Decision Package'. The report purpose was to comprehensively evaluate and discuss packaging, storage, and transportation for all potential nuclear and radioactive materials in the process and waste streams being considered by the GNEP program. In particular, a systems view was used to capture all packaging, storage, and transport operations needed to link the various functional aspects of the fuel cycle. (6) SRNL M-TSD staff developed a deliverable report 'Management of Decay Heat from Spent Nuclear Fuel'. This report evaluated a range of options for managing the near-term decay heat associated with Cs and Sr in spent nuclear fuel (SNF) reprocessing wastes. (7) M-TSD staff participated in a series of meetings of the US-Japan GNEP Working Group on Waste Management, developing the content for the first deliverable of the working group.« less

  9. MTR BUILDING, TRA603. EAST SIDE. CAMERA FACING WEST. CORRUGATED IRON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR BUILDING, TRA-603. EAST SIDE. CAMERA FACING WEST. CORRUGATED IRON BUILDING MARKED WITH "X" IS TRA-651. TRA-626, TO ITS RIGHT, HOUSED COMPRESSOR EQUIPMENT FOR THE AIRCRAFT NUCLEAR PROPULSION PROGRAM. LATER, IT WAS USED FOR STORAGE. INL NEGATIVE NO. HD46-42-4. Mike Crane, Photographer, April 2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  10. Advanced In-Pile Instrumentation for Materials Testing Reactors

    NASA Astrophysics Data System (ADS)

    Rempe, J. L.; Knudson, D. L.; Daw, J. E.; Unruh, T. C.; Chase, B. M.; Davis, K. L.; Palmer, A. J.; Schley, R. S.

    2014-08-01

    The U.S. Department of Energy sponsors the Advanced Test Reactor (ATR) National Scientific User Facility (NSUF) program to promote U.S. research in nuclear science and technology. By attracting new research users - universities, laboratories, and industry - the ATR NSUF facilitates basic and applied nuclear research and development, advancing U.S. energy security needs. A key component of the ATR NSUF effort is to design, develop, and deploy new in-pile instrumentation techniques that are capable of providing real-time measurements of key parameters during irradiation. This paper describes the strategy developed by the Idaho National Laboratory (INL) for identifying instrumentation needed for ATR irradiation tests and the program initiated to obtain these sensors. New sensors developed from this effort are identified, and the progress of other development efforts is summarized. As reported in this paper, INL researchers are currently involved in several tasks to deploy real-time length and flux detection sensors, and efforts have been initiated to develop a crack growth test rig. Tasks evaluating `advanced' technologies, such as fiber-optics based length detection and ultrasonic thermometers, are also underway. In addition, specialized sensors for real-time detection of temperature and thermal conductivity are not only being provided to NSUF reactors, but are also being provided to several international test reactors.

  11. MISCELLANEOUS ARCHITECTURAL DETAILS OF REMOTE ANALYTICAL FACILITY (CPP627). INL DRAWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MISCELLANEOUS ARCHITECTURAL DETAILS OF REMOTE ANALYTICAL FACILITY (CPP-627). INL DRAWING NUMBER 200-0627-00-098-105631. ALTERNATE ID NUMBER 4272-814-134. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  12. SOUTH ELEVATION OF HOT PILOT PLANT (CPP640) LOOKING NORTH. INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH ELEVATION OF HOT PILOT PLANT (CPP-640) LOOKING NORTH. INL PHOTO NUMBER HD-22-3-1. Mike Crane, Photographer, 11/1998 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  13. BUILDING PLANS OF FUEL STORAGE BUILDING (CPP603). INL DRAWING NUMBER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    BUILDING PLANS OF FUEL STORAGE BUILDING (CPP-603). INL DRAWING NUMBER 200-0603-61-299-103029. ALTERNATE ID NUMBER 542-31-B-21. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  14. CONSTRUCTION PROGRESS PHOTO OF REMOTE ANALYTICAL FACILITY (CPP627). INL PHOTO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO OF REMOTE ANALYTICAL FACILITY (CPP-627). INL PHOTO NUMBER NRTS-54-12573. R.G. Larsen, Photographer, 10/20/1954 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  15. SOUTH ELEVATION OF MAIN PROCESSING BUILDING (CPP601) LOOKING NORTH. INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH ELEVATION OF MAIN PROCESSING BUILDING (CPP-601) LOOKING NORTH. INL PHOTO NUMBER HD-22-5-3. Mike Crane, Photographer, 11/1998 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  16. An internalin a probe-based genosensor for Listeria monocytogenes detection and differentiation.

    PubMed

    Bifulco, Laura; Ingianni, Angela; Pompei, Raffaello

    2013-01-01

    Internalin A (InlA), a protein required for Listeria monocytogenes virulence, is encoded by the inlA gene, which is only found in pathogenic strains of this genus. One of the best ways to detect and confirm the pathogenicity of the strain is the detection of one of the virulence factors produced by the microorganism. This paper focuses on the design of an electrochemical genosensor used to detect the inlA gene in Listeria strains without labelling the target DNA. The electrochemical sensor was obtained by immobilising an inlA gene probe (single-stranded oligonucleotide) on the surfaces of screen-printed gold electrodes (Au-SPEs) by means of a mercaptan-activated self-assembled monolayer (SAM). The hybridisation reaction occurring on the electrode surface was electrochemically transduced by differential pulse voltammetry (DPV) using methylene blue (MB) as an indicator. The covalently immobilised single-stranded DNA was able to selectively hybridise to its complementary DNA sequences in solution to form double-stranded DNA on the gold surface. A significant decrease of the peak current of the voltammogram (DPV) upon hybridisation of immobilised ssDNA was recorded. Whole DNA samples of L. monocytogenes strains could be discriminated from other nonpathogenic Listeria species DNA with the inlA gene DNA probe genosensor.

  17. Nondestructive Evaluation of the VSC-17 Cask

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sheryl Morton; Al Carlson; Cecilia Hoffman

    2006-01-01

    In 2003, representatives from the Central Research Institute of Electric Power Industry (CRIEPI) requested development of a project with the objective of determining the performance of a concrete spent nuclear fuel storage cask. Radiation and environmental effects may cause chemical alteration of the concrete that could result in excessive cracking, spalling, and loss of compressive strength. The Idaho National Laboratory (INL) project team and CRIEPI representatives identified the Ventilated Storage Cask (VSC 17) spent nuclear fuel storage cask, originally located at the INL Test Area North, as a candidate to study cask performance because it had been used to storemore » fuel as part of a dry cask storage demonstration project for over 15 years. The project involved investigating the properties of the concrete shield. INL performed a survey of the cask in the summers of 2003 and 2004. The INL team met with the CRIEPI representatives in December of 2004 to discuss the next steps. As a result of that meeting, CRIEPI requested that in the summer 2005 INL perform additional surveys on the VSC 17 cask with participation of CRIEPI scientists. This document summarizes the evaluation methods used on the VSC 17 to evaluate the cask for compressive strength, concrete cracking, concrete thickness, and temperature distribution.« less

  18. Improvement of Nonlinearity Correction for BESIII ETOF Upgrade

    NASA Astrophysics Data System (ADS)

    Sun, Weijia; Cao, Ping; Ji, Xiaolu; Fan, Huanhuan; Dai, Hongliang; Zhang, Jie; Liu, Shubin; An, Qi

    2015-08-01

    An improved scheme to implement integral non-linearity (INL) correction of time measurements in the Beijing Spectrometer III Endcap Time-of-Flight (BESIII ETOF) upgrade system is presented in this paper. During upgrade, multi-gap resistive plate chambers (MRPC) are introduced as ETOF detectors which increases the total number of time measurement channels to 1728. The INL correction method adopted in BESIII TOF proved to be of limited use, because the sharply increased number of electronic channels required for reading out the detector strips degrade the system configuration efficiency severely. Furthermore, once installed into the spectrometer, BESIII TOF electronics do not support the TDCs' nonlinearity evaluation online. In this proposed method, INL data used for the correction algorithm are automatically imported from a non-volatile read-only memory (ROM) instead of from data acquisition software. This guarantees the real-time performance and system efficiency of the INL correction, especially for the ETOF upgrades with massive number of channels. Besides, a signal that is not synchronized to the system 41.65 MHz clock from BEPCII is sent to the frontend electronics (FEE) to simulate pseudo-random test pulses for the purpose of online nonlinearity evaluation. Test results show that the time measuring INL errors in one module with 72 channels can be corrected online and in real time.

  19. MISCELLANEOUS SECTIONS AND DETAILS OF FUEL STORAGE BUILDING (CPP603). INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MISCELLANEOUS SECTIONS AND DETAILS OF FUEL STORAGE BUILDING (CPP-603). INL DRAWING NUMBER 200-0603-61-299-103032. ALTERNATE ID NUMBER 542-31-B-24. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  20. SOUTH ELEVATION AND DETAILS OF MAIN PROCESSING BUILDING (CPP601). INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH ELEVATION AND DETAILS OF MAIN PROCESSING BUILDING (CPP-601). INL DRAWING NUMBER 200-0601-00-291-103082. ALTERNATE ID NUMBER 542-12-B-76. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  1. ARCHITECTURAL WALL SECTIONS OF HOT PILOT PLANT (CPP640). INL DRAWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARCHITECTURAL WALL SECTIONS OF HOT PILOT PLANT (CPP-640). INL DRAWING NUMBER 200-0640-00-279-111682. ALTERNATE ID NUMBER 8952-CPP-640-A-5. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  2. NORTH AND SOUTH SECTIONS OF REMOTE ANALYTICAL FACILITY (CPP627). INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTH AND SOUTH SECTIONS OF REMOTE ANALYTICAL FACILITY (CPP-627). INL DRAWING NUMBER 200-0627-00-098-105068. ALTERNATE ID NUMBER 4272-14-105. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  3. EAST AND WEST ELEVATIONS OF REMOTE ANALYTICAL FACILITY (CPP627). INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST AND WEST ELEVATIONS OF REMOTE ANALYTICAL FACILITY (CPP-627). INL DRAWING NUMBER 200-0627-00-098-105067. ALTERNATE ID NUMBER 4272-14-104. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  4. EAST AND WEST ELEVATIONS OF MAIN PROCESSING BUILDING (CPP601). INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST AND WEST ELEVATIONS OF MAIN PROCESSING BUILDING (CPP-601). INL DRAWING NUMBER 200-0601-00-291-103081. ALTERNATE ID NUMBER 542-11-B-75. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  5. WEST ELEVATIONS AND SECTIONS OF FUEL STORAGE BUILDING (CPP603). INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WEST ELEVATIONS AND SECTIONS OF FUEL STORAGE BUILDING (CPP-603). INL DRAWING NUMBER 200-063-61-299-103031. ALTERNATE ID NUMBER 542-31-B-23. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  6. MISCELLANEOUS ARCHITECTURAL DETAILS OF HOT PILOT PLANT (CPP640). INL DRAWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MISCELLANEOUS ARCHITECTURAL DETAILS OF HOT PILOT PLANT (CPP-640). INL DRAWING NUMBER 200-640-00-279-111684. ALTERNATE ID NUMBER 8952-CPP-640-A-7. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  7. SIDING AND ROOF DETAILS OF FUEL STORAGE BUILDING (CPP603). INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SIDING AND ROOF DETAILS OF FUEL STORAGE BUILDING (CPP-603). INL DRAWING NUMBER 200-0603-61-299-103033. ALTERNATE ID NUMBER 542-31-B-25. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  8. BUILDING DETAILS AND SECTIONS OF MAIN PROCESSING BUILDING (CPP601). INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    BUILDING DETAILS AND SECTIONS OF MAIN PROCESSING BUILDING (CPP-601). INL DRAWING NUMBER 200-0601-00-291-103080. ALTERNATE ID NUMBER 542-11-B-74. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  9. STRUCTURAL DETAILS AND SECTIONS OF MAIN PROCESSING BUILDING (CPP601). INL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    STRUCTURAL DETAILS AND SECTIONS OF MAIN PROCESSING BUILDING (CPP-601). INL DRAWING NUMBER 200-0601-00-291-103079. ALTERNATE ID NUMBER 542-11-B-73. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  10. Influence of Technological Treatments on the Functionality of Bifidobacterium lactis INL1, a Breast Milk-Derived Probiotic.

    PubMed

    Zacarías, María Florencia; Souza, Tassia Costa; Zaburlín, Natalia; Carmona Cara, Denise; Reinheimer, Jorge; Nicoli, Jacques; Vinderola, Gabriel

    2017-10-01

    The aim of this study is to evaluate the influence of the technological processing on the functionality of the human breast milk probiotic strain Bifidobacterium lactis INL1. In vitro antagonistic activity of B. lactis INL1 was detected for Gram-positive and Gram-negative pathogens. B. lactis INL1 was administered to mice as fresh (F), frozen (Z), spray-dried (S), or lyophilized (L) culture. Immune parameters (IgA, IL-10, and IFN-γ) were determined and histological analysis was performed to assess functionality and protection capacity against Salmonella. In BALB/c mice, F and S cultures induced an increase in the number of IgA-producing cells in the small intestine and IL-10 levels were increased for L culture in the large intestine. In Swiss mice, B. lactis INL1 increased secretory-IgA levels in the small intestine before and after Salmonella infection, both as F or dehydrated culture. Also, an attenuation of damage in the intestinal epithelium and less inflammatory infiltrates were observed in animals that received F and S cultures, whereas in liver only F showed some effect. The anti-inflammatory effect was confirmed in both tissues by myeloperoxidase activity and by IFN-γ levels in the intestinal content. B. lactis INL1 showed inhibitory activity against pathogens and confirmed its probiotic potential in animal models. Technological processing of the probiotic strain affected its functionality. This work provides evidence about the influence of technology on the functionality of probiotics, which may help probiotics and functional food manufacturers to take processing into consideration when assessing the functionality of new strains. © 2017 Institute of Food Technologists®.

  11. Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin.

    PubMed

    Lecuit, Marc; Nelson, D Michael; Smith, Steve D; Khun, Huot; Huerre, Michel; Vacher-Lavenu, Marie-Cécile; Gordon, Jeffrey I; Cossart, Pascale

    2004-04-20

    Listeria monocytogenes produces severe fetoplacental infections in humans. How it targets and crosses the maternofetal barrier is unknown. We used immunohistochemistry to examine the location of L. monocytogenes in placental and amniotic tissue samples obtained from women with fetoplacental listeriosis. The results raised the possibility that L. monocytogenes crosses the maternofetal barrier through the villous syncytiotrophoblast, with secondary infection occurring via the amniotic epithelium. Because epidemiological studies indicate that the bacterial surface protein, internalin (InlA), may play a role in human fetoplacental listeriosis, we investigated the cellular patterns of expression of its host receptor, E-cadherin, at the maternofetal interface. E-cadherin was found on the basal and apical plasma membranes of syncytiotrophoblasts and in villous cytotrophoblasts. Established trophoblastic cell lines, primary trophoblast cultures, and placental villous explants were each exposed to isogenic InlA+ or InlA- strains of L. monocytogenes, and to L. innocua expressing or not InlA. Quantitative assays of cellular invasion demonstrated that bacterial entry into syncytiotrophoblasts occurs via the apical membrane in an InlA-E-cadherin dependent manner. In human placental villous explants, bacterial invasion of the syncytiotrophoblast barrier and underlying villous tissue and subsequent replication produces histopathological lesions that mimic those seen in placentas of women with listeriosis. Thus, the InlA-E-cadherin interaction that plays a key role in the crossing of the intestinal barrier in humans is also exploited by L. monocytogenes to target and cross the placental barrier. Such a ligand-receptor interaction allowing a pathogen to specifically cross the placental villous trophoblast barrier has not been reported previously.

  12. Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: Role of internalin interaction with trophoblast E-cadherin

    PubMed Central

    Lecuit, Marc; Nelson, D. Michael; Smith, Steve D.; Khun, Huot; Huerre, Michel; Vacher-Lavenu, Marie-Cécile; Gordon, Jeffrey I.; Cossart, Pascale

    2004-01-01

    Listeria monocytogenes produces severe fetoplacental infections in humans. How it targets and crosses the maternofetal barrier is unknown. We used immunohistochemistry to examine the location of L. monocytogenes in placental and amniotic tissue samples obtained from women with fetoplacental listeriosis. The results raised the possibility that L. monocytogenes crosses the maternofetal barrier through the villous syncytiotrophoblast, with secondary infection occurring via the amniotic epithelium. Because epidemiological studies indicate that the bacterial surface protein, internalin (InlA), may play a role in human fetoplacental listeriosis, we investigated the cellular patterns of expression of its host receptor, E-cadherin, at the maternofetal interface. E-cadherin was found on the basal and apical plasma membranes of syncytiotrophoblasts and in villous cytotrophoblasts. Established trophoblastic cell lines, primary trophoblast cultures, and placental villous explants were each exposed to isogenic InlA+ or InlA- strains of L. monocytogenes, and to L. innocua expressing or not InlA. Quantitative assays of cellular invasion demonstrated that bacterial entry into syncytiotrophoblasts occurs via the apical membrane in an InlA–E-cadherin dependent manner. In human placental villous explants, bacterial invasion of the syncytiotrophoblast barrier and underlying villous tissue and subsequent replication produces histopathological lesions that mimic those seen in placentas of women with listeriosis. Thus, the InlA–E-cadherin interaction that plays a key role in the crossing of the intestinal barrier in humans is also exploited by L. monocytogenes to target and cross the placental barrier. Such a ligand–receptor interaction allowing a pathogen to specifically cross the placental villous trophoblast barrier has not been reported previously. PMID:15073336

  13. Experimental studies of Micro- and Nano-grained UO 2: Grain Growth Behavior, Sufrace Morphology, and Fracture Toughness

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miao, Yinbin; Mo, Kun; Jamison, Laura M.

    This activity is supported by the US Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Product Line (FPL) and aims at providing experimental data for the validation of the mesoscale simulation code MARMOT. MARMOT is a mesoscale multiphysics code that predicts the coevolution of microstructure and properties within reactor fuel during its lifetime in the reactor. It is an important component of the Moose-Bison-Marmot (MBM) code suite that has been developed by Idaho National Laboratory (INL) to enable next generation fuel performance modeling capability as part of the NEAMS Program FPL. In order to ensure the accuracy of the microstructure-basedmore » materials models being developed within the MARMOT code, extensive validation efforts must be carried out. In this report, we summarize the experimental efforts in FY16 including the following important experiments: (1) in-situ grain growth measurement of nano-grained UO 2; (2) investigation of surface morphology in micrograined UO 2; (3) Nano-indentation experiments on nano- and micro-grained UO 2. The highlight of this year is: we have successfully demonstrated our capability to in-situ measure grain size development while maintaining the stoichiometry of nano-grained UO 2 materials; the experiment is, for the first time, using synchrotron X-ray diffraction to in-situ measure grain growth behavior of UO 2.« less

  14. Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2011

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    David W. Nigg; Devin A. Steuhm

    2011-09-01

    Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance and, to some extent, experiment management are obsolete, inconsistent with the state of modern nuclear engineering practice, and are becoming increasingly difficult to properly verify and validate (V&V). Furthermore, the legacy staff knowledge required for application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In 2009 the Idaho National Laboratory (INL) initiated a focused effort to address this situation through the introduction of modern high-fidelitymore » computational software and protocols, with appropriate V&V, within the next 3-4 years via the ATR Core Modeling and Simulation and V&V Update (or 'Core Modeling Update') Project. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF). The ATR Core Modeling Update Project, targeted for full implementation in phase with the anticipated ATR Core Internals Changeout (CIC) in the 2014 time frame, began during the last quarter of Fiscal Year 2009, and has just completed its first full year. Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (SCALE, KENO-6, HELIOS, NEWT, and ATTILA) have been installed at the INL under various permanent sitewide license agreements and corresponding baseline models of the ATR and ATRC are now operational, demonstrating the basic feasibility of these code packages for their intended purpose. Furthermore, a capability for rigorous sensitivity analysis and uncertainty quantification based on the TSUNAMI system is being implemented and initial computational results have been obtained. This capability will have many applications in 2011 and beyond as a tool for understanding the margins of uncertainty in the new models as well as for validation experiment design and interpretation. Finally we note that although full implementation of the new computational models and protocols will extend over a period 3-4 years as noted above, interim applications in the much nearer term have already been demonstrated. In particular, these demonstrations included an analysis that was useful for understanding the cause of some issues in December 2009 that were triggered by a larger than acceptable discrepancy between the measured excess core reactivity and a calculated value that was based on the legacy computational methods. As the Modeling Update project proceeds we anticipate further such interim, informal, applications in parallel with formal qualification of the system under the applicable INL Quality Assurance procedures and standards.« less

  15. High affinity anti-Internalin B VHH antibody fragments isolated from naturally and artificially immunized repertoires.

    PubMed

    Gene, Robert W; Kumaran, Jyothi; Aroche, Cristina; van Faassen, Henk; Hall, J Christopher; MacKenzie, C Roger; Arbabi-Ghahroudi, Mehdi

    2015-01-01

    The need for rapid and easy technologies for the detection of food-borne and environmental pathogens is essential for safeguarding the health of populations. Furthermore, distribution of tainted food and water can have consequences which can affect whole economies. Antibodies and antibody fragments have been historically used in detection platforms due to their antigen specificity and robust physicochemical properties. In this study, we report the isolation and characterization of antibody fragments from the heavy chain antibody repertoire (VHH) of Camelidae which bind with specificity and high affinity to the Listeria monocytogenes invasin, Internalin B (InlB). To the best of our knowledge, this is the first report of anti-InlB VHHs from camelids. These anti-InlB VHHs were not cross-reactive to the structurally related Listeria invasin Internalin A (InlA) and are potential reagents to be used in the development of detection and medical technologies. Copyright © 2014. Published by Elsevier B.V.

  16. The Transient Intermediate Plexiform Layer, a Plexiform Layer-like Structure Temporarily Existing in the Inner Nuclear Layer in Developing Rat Retina.

    PubMed

    Park, Hyung Wook; Kim, Hong-Lim; Park, Yong Soo; Kim, In-Beom

    2018-02-01

    The retina is a highly specialised part of the brain responsible for visual processing. It is well-laminated; three layers containing five different types of neurons are compartmentalised by two synaptic layers. Among the retinal layers, the inner nuclear layer (INL) is composed of horizontal, bipolar, and amacrine cell types. Bipolar cells form one sublayer in the distal half of the IPL, while amacrine cells form another sublayer in the proximal half, without any border-like structure. Here, we report that a plexiform layer-like structure exists temporarily in the border between the bipolar and amacrine sublayers in the INL in the rat retina during retinal development. This transient intermediate plexiform layer (TIPL) appeared at postnatal day (PD) 7 and then disappeared around PD 12. Most apoptotic cells in the INL were found near the TIPL. These results suggest that the TIPL may contribute to the formation of sublayers and the cell number limit in the INL.

  17. Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model.

    PubMed

    Arikan, Sedat; Ersan, Ismail; Karaca, Turan; Kara, Selcuk; Gencer, Baran; Karaboga, Ihsan; Hasan Ali, Tufan

    2015-01-01

    This study aimed to investigate the effect of quercetin on apoptotic cell death induced by ischemia-reperfusion (I/R) injury in the rat retina. Twenty-four rats were divided into four equal groups: control, ischemic, solvent, and quercetin. I/R injury was achieved by elevating the intraocular pressure above the perfusion pressure. Intraperitoneal injections of 20 mg/kg of quercetin and dimethyl sulfoxide (DMSO) were performed in the quercetin and solvent groups, respectively, immediately prior to I/R injury, and the researchers allowed for the retinas to be reperfused. Forty-eight hours after injury, the thicknesses of the retinal ganglion cell layer (RGCL), inner nuclear layer (INL), inner plexiform layer (IPL), outer plexiform layer (OPL), and outer nuclear layer (ONL) were measured in all groups. Moreover, the numbers of terminal deoxynucleotidyl transferase dUTP nick-end-labeled [TUNEL (+)] cells and caspase-3 (+) cells in both INL and ONL were evaluated in all groups. The administration of quercetin was found to reduce the thinning of all retinal layers. The mean thickness of INL in the quercetin and ischemic groups was 21 ± 5.6 µm and 16 ± 6.4 µm, respectively (P<0.05). Similarly, the mean thickness of ONL in the quercetin and ischemic groups was 50 ± 12.8 µm and 40 ± 8.7 µm, respectively (P<0.05). The antiapoptotic effect of quercetin in terms of reducing the numbers of both TUNEL (+) cells and caspase-3 (+) cells was significant in INL. The mean number of TUNEL (+) cells in INL in the ischemic and quercetin groups was 476.8 ± 45.6/mm2 and 238.72 ± 251/mm2, respectively (P<0.005). The mean number of caspase-3 (+) cells in INL of ischemic and quercetin groups was 633.6 ± 38.7/mm2 and 342.4 ± 36.1/mm2, respectively (P<0.001). The use of quercetin may be beneficial in the treatment of retinal I/R injury because of its antiapoptotic effect on the retinal layers, particularly in INL.

  18. After Action Report: Idaho National Laboratory Annual Exercise June 10, 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barnes, Vernon Scott

    On June 10, 2015, Idaho National Laboratory (INL), in coordination with the State of Idaho, local jurisdictions, Department of Energy Idaho Operations Office (DOE-ID), and DOE Headquarters (DOE HQ), conducted the annual emergency exercise to demonstrate the ability to implement the requirements of DOE O 151.1C, “Comprehensive Emergency Management System.” The INL contractor, Battelle Energy Alliance, LLC (BEA), in coordination with other INL contractors, conducted operations and demonstrated appropriate response measures to mitigate an event and protect the health and safety of personnel, the environment, and property. Offsite response organizations participated to demonstrate appropriate response measures.

  19. A Novel ImageJ Macro for Automated Cell Death Quantitation in the Retina

    PubMed Central

    Maidana, Daniel E.; Tsoka, Pavlina; Tian, Bo; Dib, Bernard; Matsumoto, Hidetaka; Kataoka, Keiko; Lin, Haijiang; Miller, Joan W.; Vavvas, Demetrios G.

    2015-01-01

    Purpose TUNEL assay is widely used to evaluate cell death. Quantification of TUNEL-positive (TUNEL+) cells in tissue sections is usually performed manually, ideally by two masked observers. This process is time consuming, prone to measurement errors, and not entirely reproducible. In this paper, we describe an automated quantification approach to address these difficulties. Methods We developed an ImageJ macro to quantitate cell death by TUNEL assay in retinal cross-section images. The script was coded using IJ1 programming language. To validate this tool, we selected a dataset of TUNEL assay digital images, calculated layer area and cell count manually (done by two observers), and compared measurements between observers and macro results. Results The automated macro segmented outer nuclear layer (ONL) and inner nuclear layer (INL) successfully. Automated TUNEL+ cell counts were in-between counts of inexperienced and experienced observers. The intraobserver coefficient of variation (COV) ranged from 13.09% to 25.20%. The COV between both observers was 51.11 ± 25.83% for the ONL and 56.07 ± 24.03% for the INL. Comparing observers' results with macro results, COV was 23.37 ± 15.97% for the ONL and 23.44 ± 18.56% for the INL. Conclusions We developed and validated an ImageJ macro that can be used as an accurate and precise quantitative tool for retina researchers to achieve repeatable, unbiased, fast, and accurate cell death quantitation. We believe that this standardized measurement tool could be advantageous to compare results across different research groups, as it is freely available as open source. PMID:26469755

  20. The Realistic Job Preview as a Persuasive Communication.

    DTIC Science & Technology

    1982-02-01

    10. PROGRAM ELEMENT, PROJECT. TAK AREA 6 WORK UNIT NUMBERS Michigan State Uiversity NR 170-894 Ii. CONTROLLING OFFICE NAME AND ADDRESS IS. REPORT...RJP research seems to show a stronger preview effect using more intelligent subjects. That is, studies of life insurance agents (Weitz, 1956; Youngberg...University Department of Psychological Sciences west Lafayette, INl 47907 1 Dr. Philip G. Zi±bardo*2 ~ Staniford Uiversity Department of Psychology Stanford, CA 94305 <El

  1. Process and equipment development for hot isostatic pressing treatability study

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bateman, Ken; Wahlquist, Dennis; Malewitz, Tim

    2015-03-01

    Battelle Energy Alliance (BEA), LLC, has developed processes and equipment for a pilot-scale hot isostatic pressing (HIP) treatability study to stabilize and volume reduce radioactive calcine stored at Idaho National Laboratory (INL). In 2009, the U. S. Department of Energy signed a Record of Decision with the state of Idaho selecting HIP technology as the method to treat 5,800 yd^3 (4,400 m^3) of granular zirconia and alumina calcine produced between 1953 and 1992 as a waste byproduct of spent nuclear fuel reprocessing. Since the 1990s, a variety of radioactive and hazardous waste forms have been remotely treated using HIP withinmore » INL hot cells. To execute the remote process at INL, waste is loaded into a stainless-steel or aluminum can, which is evacuated, sealed, and placed into a HIP furnace. The HIP simultaneously heats and pressurizes the waste, reducing its volume and increasing its durability. Two 1 gal cans of calcine waste currently stored in a shielded cask were identified as candidate materials for a treatability study involving the HIP process. Equipment and materials for cask-handling and calcine transfer into INL hot cells, as well as remotely operated equipment for waste can opening, particle sizing, material blending, and HIP can loading have been designed and successfully tested. These results demonstrate BEA’s readiness for treatment of INL calcine.« less

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Layne Pincock; Wendell Hintze; Dr. Koji Shirai

    Following the massive earthquake and resulting tsunami damage in March of 2011 at the Fukushima Daiichi nuclear power plant in Japan, interest was amplified for what was done for recovery at the Three Mile Island Unit 2 (TMI-2) in the United States following its meltdown in 1979. Many parallels could be drawn between to two accidents. This paper presents the results of research done into the TMI-2 recovery effort and its applicability to the Fukushima Daiichi cleanup. This research focused on three topics: packaging, transportation, and disposition. This research work was performed as a collaboration between Japan’s Central Research Institutemore » of Electric Power Industry (CRIEPI) and the Idaho National Laboratory (INL). Hundreds of TMI-2 related documents were searched and pertinent information was gleaned from these documents. Other important information was also obtained by interviewing employees who were involved first hand in various aspects of the TMI-2 cleanup effort. This paper is organized into three main sections: (1) Transport from Three Mile Island to Central Facilities Area at INL, (2) Transport from INL Central Receiving Facility to INL Test Area North (TAN) and wet storage at TAN, and (3) Transport from TAN to INL Idaho Nuclear Technology and Engineering Center (INTEC) and Dry Storage at INTEC. Within each of these sections, lessons learned from performing recovery activities are presented and their applicability to the Fukushima Daiichi nuclear power plant cleanup are outlined.« less

  3. Physics Teachers Workshop

    ScienceCinema

    Huggins, DaNel; Calhoun, John; Palmer, Alyson; Thorpe, Steve; Vanderveen, Anne

    2017-12-09

    INL is looking for the nation's top high school physics teachers to attend our July workshop in Idaho Falls. Participants get to learn from nuclear researchers, tour facilities including a research reactor and interact with peers from across the country. You can learn more about INL projects at http://www.facebook.com/idahonationallaboratory

  4. Physics Teachers Workshop

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Huggins, DaNel; Calhoun, John; Palmer, Alyson

    INL is looking for the nation's top high school physics teachers to attend our July workshop in Idaho Falls. Participants get to learn from nuclear researchers, tour facilities including a research reactor and interact with peers from across the country. You can learn more about INL projects at http://www.facebook.com/idahonationallaboratory

  5. Advanced Vehicle Testing Activity Cold Weather On-road Testing of the Chevrolet Volt

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smart, John

    This report details cold weather on-road testing of a Chevrolet Volt. It quantifies changes in efficiency and electric range as ambient temperature changes. It will be published to INL's AVTA website as an INL technical report and will be accessible to the general public.

  6. DEFLECTION OF A HETEROGENEOUS WIDE-BEAM UNDER UNIFORM PRESSURE LOAD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    T. V. Holschuh; T. K. Howard; W. R. Marcum

    2014-07-01

    Oregon State University (OSU) and the Idaho National Laboratory (INL) are currently collaborating on a test program which entails hydro-mechanical testing of a generic plate type fuel element, or generic test plate assembly (GTPA), for the purpose of qualitatively demonstrating mechanical integrity of uranium-molybdenum monolithic plates as compared to that of uranium aluminum dispersion, and aluminum fuel plates onset by hydraulic forces. This test program supports ongoing work conducted for/by the Global Threat Reduction Initiative (GTRI) Fuels Development Program. This study’s focus supports the ongoing collaborative effort by detailing the derivation of an analytic solution for deflection of a heterogeneousmore » plate under a uniform, distributed load in order to predict the deflection of test plates in the GTPA. The resulting analytical solutions for three specific boundary condition sets are then presented against several test cases of a homogeneous plate. In all test cases considered, the results for both homogeneous and heterogeneous plates are numerically identical to one another, demonstrating correct derivation of the heterogeneous solution. Two additional problems are presents herein that provide a representative deflection profile for the plates under consideration within the GTPA. Furthermore, qualitative observations are made about the influence of a more-rigid internal fuel-meat region and its influence on the overall deflection profile of a plate. Present work is being directed to experimentally confirm the analytical solution’s results using select materials.« less

  7. Synchrotron characterization of nanograined UO 2 grain growth

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mo, Kun; Miao, Yinbin; Yun, Di

    2015-09-30

    This activity is supported by the US Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Product Line (FPL) and aims at providing experimental data for the validation of the mesoscale simulation code MARMOT. MARMOT is a mesoscale multiphysics code that predicts the coevolution of microstructure and properties within reactor fuel during its lifetime in the reactor. It is an important component of the Moose-Bison-Marmot (MBM) code suite that has been developed by Idaho National Laboratory (INL) to enable next generation fuel performance modeling capability as part of the NEAMS Program FPL. In order to ensure the accuracy of the microstructuremore » based materials models being developed within the MARMOT code, extensive validation efforts must be carried out. In this report, we summarize our preliminary synchrotron radiation experiments at APS to determine the grain size of nanograin UO 2. The methodology and experimental setup developed in this experiment can directly apply to the proposed in-situ grain growth measurements. The investigation of the grain growth kinetics was conducted based on isothermal annealing and grain growth characterization as functions of duration and temperature. The kinetic parameters such as activation energy for grain growth for UO 2 with different stoichiometry are obtained and compared with molecular dynamics (MD) simulations.« less

  8. Supplying materials needed for grain growth characterizations of nano-grained UO 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mo, Kun; Miao, Yinbin; Yun, Di

    2015-09-30

    This activity is supported by the US Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Product Line (FPL) and aims at providing experimental data for the validation of the mesoscale simulation code MARMOT. MARMOT is a mesoscale multiphysics code that predicts the coevolution of microstructure and properties within reactor fuel during its lifetime in the reactor. It is an important component of the Moose-Bison-Marmot (MBM) code suite that has been developed by Idaho National Laboratory (INL) to enable next generation fuel performance modeling capability as part of the NEAMS Program FPL. In order to ensure the accuracy of the microstructuremore » based materials models being developed within the MARMOT code, extensive validation efforts must be carried out. In this report, we summarize our preliminary synchrotron radiation experiments at APS to determine the grain size of nanograin UO 2. The methodology and experimental setup developed in this experiment can directly apply to the proposed in-situ grain growth measurements. The investigation of the grain growth kinetics was conducted based on isothermal annealing and grain growth characterization as functions of duration and temperature. The kinetic parameters such as activation energy for grain growth for UO 2 with different stoichiometry are obtained and compared with molecular dynamics (MD) simulations.« less

  9. Feedstock Supply System Design and Economics for Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels Conversion Pathway: Fast Pyrolysis and Hydrotreating Bio-Oil Pathway "The 2017 Design Case"

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kevin L. Kenney; Kara G. Cafferty; Jacob J. Jacobson

    The U.S. Department of Energy promotes the production of liquid fuels from lignocellulosic biomass feedstocks by funding fundamental and applied research that advances the state of technology in biomass sustainable supply, logistics, conversion, and overall system sustainability. As part of its involvement in this program, Idaho National Laboratory (INL) investigates the feedstock logistics economics and sustainability of these fuels. Between 2000 and 2012, INL quantified and the economics and sustainability of moving biomass from the field or stand to the throat of the conversion process using conventional equipment and processes. All previous work to 2012 was designed to improve themore » efficiency and decrease costs under conventional supply systems. The 2012 programmatic target was to demonstrate a biomass logistics cost of $55/dry Ton for woody biomass delivered to fast pyrolysis conversion facility. The goal was achieved by applying field and process demonstration unit-scale data from harvest, collection, storage, preprocessing, handling, and transportation operations into INL’s biomass logistics model.« less

  10. PIE on Safety-Tested AGR-1 Compact 5-1-1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunn, John D.; Morris, Robert Noel; Baldwin, Charles A.

    Post-irradiation examination (PIE) is being performed in support of tristructural isotropic (TRISO) coated particle fuel development and qualification for High-Temperature Gas-cooled Reactors (HTGRs). AGR-1 was the first in a series of TRISO fuel irradiation experiments initiated in 2006 under the Advanced Gas Reactor (AGR) Fuel Development and Qualification Program; this work continues to be funded by the Department of Energy's Office of Nuclear Energy as part of the Advanced Reactor Technologies (ART) initiative. AGR-1 fuel compacts were fabricated at Oak Ridge National Laboratory (ORNL) in 2006 and irradiated for three years in the Idaho National Laboratory (INL) Advanced Test Reactormore » (ATR) to demonstrate and evaluate fuel performance under HTGR irradiation conditions. PIE is being performed at INL and ORNL to study how the fuel behaved during irradiation, and to examine fuel performance during exposure to elevated temperatures at or above temperatures that could occur during a depressurized conduction cooldown event. This report summarizes safety testing of irradiated AGR-1 Compact 5-1-1 in the ORNL Core Conduction Cooldown Test Facility (CCCTF) and post-safety testing PIE.« less

  11. INL Control System Situational Awareness Technology Final Report 2013

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gordon Rueff; Bryce Wheeler; Todd Vollmer

    The Situational Awareness project is a comprehensive undertaking of Idaho National Laboratory (INL) in an effort to produce technologies capable of defending the country’s energy sector infrastructure from cyber attack. INL has addressed this challenge through research and development of an interoperable suite of tools that safeguard critical energy sector infrastructure. The technologies in this project include the Sophia Tool, Mesh Mapper (MM) Tool, Intelligent Cyber Sensor (ICS) Tool, and Data Fusion Tool (DFT). Each is designed to function effectively on its own, or they can be integrated in a variety of customized configurations based on the end user’s riskmore » profile and security needs.« less

  12. Techno-economic analysis of a biomass depot

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jacobson, Jacob Jordan; Lamers, Patrick; Roni, Mohammad Sadekuzzaman

    2014-10-01

    The U.S. Department of Energy (DOE) Bioenergy Technologies Office (BETO) promotes the production of an array of liquid fuels and fuel blendstocks from lignocellulosic biomass feedstocks by funding fundamental and applied research that advances the state of technology in biomass collection, conversion, and sustainability. As part of its involvement in this program, the Idaho National Laboratory (INL) investigates the technical, economic, and environmental performance of different feedstock supply systems and their impacts on the downstream conversion processes.

  13. NSUF Irradiated Materials Library

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cole, James Irvin

    The Nuclear Science User Facilities has been in the process of establishing an innovative Irradiated Materials Library concept for maximizing the value of previous and on-going materials and nuclear fuels irradiation test campaigns, including utilization of real-world components retrieved from current and decommissioned reactors. When the ATR national scientific user facility was established in 2007 one of the goals of the program was to establish a library of irradiated samples for users to access and conduct research through competitively reviewed proposal process. As part of the initial effort, staff at the user facility identified legacy materials from previous programs thatmore » are still being stored in laboratories and hot-cell facilities at the INL. In addition other materials of interest were identified that are being stored outside the INL that the current owners have volunteered to enter into the library. Finally, over the course of the last several years, the ATR NSUF has irradiated more than 3500 specimens as part of NSUF competitively awarded research projects. The Logistics of managing this large inventory of highly radioactive poses unique challenges. This document will describe materials in the library, outline the policy for accessing these materials and put forth a strategy for making new additions to the library as well as establishing guidelines for minimum pedigree needed to be included in the library to limit the amount of material stored indefinitely without identified value.« less

  14. Advanced Polymer Technology for Containing and Immobilizing Strontium-90 in the Subsurface - 8361

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    K. Baker; G. Heath; C. Scott

    2008-02-01

    Many Department of Energy (DOE) sites, including Idaho and Hanford, have heavy metals and/or radionuclides (e.g. strontium-90) present that are strongly adsorbed in the vadose zone, but which nevertheless are propagating toward the water table. A key challenge for immobilization of these contaminants is bringing the chosen amendment or remediation technology into contact with the contaminated porous medium, while ensuring that contaminated water and colloids do not escape. This is particularly challenging when the subsurface geology is complex and highly heterogeneous, as is the case at many DOE sites. The Idaho National Laboratory (INL) in collaboration with the University ofmore » Texas at Austin (UT) has conducted research sponsored through the DOE Office of Environmental Management (EM) Advanced Remediation Technologies Phase I program that successfully demonstrated application of a novel, pH-triggered advanced polymer for creating a physical barrier that prevents heavy metals and radionuclides in vadose zone soil and soil-pore water from migrating to the groundwater. The focus of this paper is on the column and sandbox experiments conducted by researchers at the Idaho National Laboratory in support of the Phase I program objectives. Proof of these concepts provides a technology basis for confining or isolating a volume of contaminated groundwater, to be implemented in future investigations at the Vadose Zone Research Park (VZRP) at INL.« less

  15. PROCESS WATER BUILDING, TRA605. CONTROL PANEL SUPPLIES STATUS INDICATORS. CARD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PROCESS WATER BUILDING, TRA-605. CONTROL PANEL SUPPLIES STATUS INDICATORS. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION ON ORIGINAL NEGATIVE. INL NEGATIVE NO. 4219. Unknown Photographer, 2/13/1952 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  16. DHS National Technical Nuclear Forensics Program FY 10 Summary Report: Graduate Mentoring Assistance Program (GMAP)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martha R. Finck Ph.D.

    2011-10-01

    This program provides practical training to DHS graduate fellows in the DOE laboratory complex. It involves coordinating students, their thesis advisors, and their laboratory project mentors in establishing a meaningful program of research which contributes to the graduate student's formation as a member of the nuclear forensics community. The summary report details the student/mentor experience and future plans after the first summer practicum. This program provides practical training to DHS graduate fellows in the DOE laboratory complex. It involves coordinating students, their thesis advisors, and their laboratory project mentors in establishing a meaningful program of research which contributes to themore » graduate student's formation as a member of the nuclear forensics community. This final written report includes information concerning the overall mentoring experience, including benefits (to the lab, the mentors, and the students), challenges, student research contributions, and lab mentor interactions with students home universities. Idaho National Laboratory hosted two DHS Nuclear Forensics graduate Fellows (nuclear engineering) in summer 2011. Two more Fellows (radiochemistry) are expected to conduct research at the INL under this program starting in 2012. An undergraduate Fellow (nuclear engineering) who worked in summer 2011 at the laboratory is keenly interested in applying for the NF Graduate Fellowship this winter with the aim of returning to INL. In summary, this program appears to have great potential for success in supporting graduate level students who pursue careers in nuclear forensics. This relatively specialized field may not have been an obvious choice for some who have already shown talent in the traditional areas of chemistry or nuclear engineering. The active recruiting for this scholarship program for candidates at universities across the U.S. brings needed visibility to this field. Not only does this program offer critical practical training to these students, it brings attention to a very attractive field of work where young professionals are urgently required in order for the future. The effectiveness of retaining such talent remains to be seen and may be primarily controlled by the availability of DOE laboratory research funding in this field in the years to come.« less

  17. Expression of ionotropic glutamate receptors, AMPA, kainite and NMDA, in the pigeon retina.

    PubMed

    Atoji, Yasuro

    2015-07-01

    Glutamate is an excitatory neurotransmitter in the vertebrate retina. A previous study found vesicular glutamate transporter 2 (vGluT2) mRNA in the pigeon retina, suggesting that bipolar and ganglion cells are glutamatergic. The present study examined the localization of ionotropic glutamate receptors to identify receptor cells in the pigeon retina using in situ hybridization histochemistry. Nine subunits of AMPA receptor (GluA1, GluA2, GluA3, and GluA4), kainate receptor (GluK1, GluK2, and GluK4), and NMDA receptor (GluN1 and GluN2A) were found to be expressed in the inner nuclear layer (INL) and ganglion cell layers. GluA1, GluA2, GluA3, and GluA4 were primarily expressed in the inner half of INL, and the signal intensity was strong for GluA2, GluA3, and GluA4. GluK1 was intensely expressed in the outer half of INL, whereas GluK2 and GluK4 were mainly localized in the inner half of INL. GluN1 and GluN2A were moderately expressed in the inner half of INL. Horizontal cells expressed GluA3 and GluA4, and ganglion cells expressed all subunits examined. These results suggest that the glutamatergic neurotransmission in the pigeon retina is similar to that in mammals. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Experimental oral iron administration: Histological investigations and expressions of iron handling proteins in rat retina with aging.

    PubMed

    Kumar, Pankaj; Nag, Tapas Chandra; Jha, Kumar Abhiram; Dey, Sanjay Kumar; Kathpalia, Poorti; Maurya, Meenakshi; Gupta, Chandan Lal; Bhatia, Jagriti; Roy, Tara Sankar; Wadhwa, Shashi

    2017-12-01

    Iron is implicated in age-related macular degeneration (AMD). The aim of this study was to see if long-term, experimental iron administration with aging modifies retinal and choroidal structures and expressions of iron handling proteins, to understand some aspects of iron homeostasis. Male Wistar rats were fed with ferrous sulphate heptahydrate (500mg/kg body weight/week, oral; elemental iron availability: 20%) from 2 months of age onward until they were 19.5 month-old. At 8, 14 and 20 months of age, they were sacrificed and serum and retinal iron levels were detected by HPLC. Oxidative stress was analyzed by TBARS method. The retinas were examined for cell death (TUNEL), histology (electron microscopy) and the expressions of transferrin, transferrin receptor-1 [TFR-1], H- and L-ferritin. In control animals, at any age, there was no difference in the serum and retinal iron levels, but the latter increased significantly in 14- and 20 month-old iron-fed rats, indicating that retinal iron accumulation proceeds with progression of aging (>14 months). The serum and retinal TBARS levels increased significantly with progression of aging in experimental but not in control rats. There was significant damage to choriocapillaris, accumulation of phagosomes in retinal pigment epithelium and increased incidence of TUNEL+ cells in outer nuclear layer and vacuolation in inner nuclear layer (INL) of 20 month-aged experimental rats, compared to those in age-matched controls. Vacuolations in INL could indicate a long-term effect of iron accumulation in the inner retina. These events paralleled the increased expression of ferritins and transferrin and a decrease in the expression of TFR-1 in iron-fed rats with aging, thereby maintaining iron homeostasis in the retina. As some of these changes mimic with those happening in eyes with AMD, this model can be utilized to understand iron-induced pathophysiological changes in AMD. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Combining Experiments and Simulations of Extraction Kinetics and Thermodynamics in Advanced Separation Processes for Used Nuclear Fuel

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nilsson, Mikael

    This 3-year project was a collaboration between University of California Irvine (UC Irvine), Pacific Northwest National Laboratory (PNNL), Idaho National Laboratory (INL), Argonne National Laboratory (ANL) and with an international collaborator at ForschungZentrum Jülich (FZJ). The project was led from UC Irvine under the direction of Profs. Mikael Nilsson and Hung Nguyen. The leads at PNNL, INL, ANL and FZJ were Dr. Liem Dang, Dr. Peter Zalupski, Dr. Nathaniel Hoyt and Dr. Giuseppe Modolo, respectively. Involved in this project at UC Irvine were three full time PhD graduate students, Tro Babikian, Ted Yoo, and Quynh Vo, and one MS student,more » Alba Font Bosch. The overall objective of this project was to study how the kinetics and thermodynamics of metal ion extraction can be described by molecular dynamic (MD) simulations and how the simulations can be validated by experimental data. Furthermore, the project includes the applied separation by testing the extraction systems in a single stage annular centrifugal contactor and coupling the experimental data with computational fluid dynamic (CFD) simulations. Specific objectives of the proposed research were: Study and establish a rigorous connection between MD simulations based on polarizable force fields and extraction thermodynamic and kinetic data. Compare and validate CFD simulations of extraction processes for An/Ln separation using different sizes (and types) of annular centrifugal contactors. Provide a theoretical/simulation and experimental base for scale-up of batch-wise extraction to continuous contactors. We approached objective 1 and 2 in parallel. For objective 1 we started by studying a well established extraction system with a relatively simple extraction mechanism, namely tributyl phosphate. What we found was that well optimized simulations can inform experiments and new information on TBP behavior was presented in this project, as well be discussed below. The second objective proved a larger challenge and most of the efforts were devoted to experimental studies.« less

  20. Lactococcus lactis expressing either Staphylococcus aureus fibronectin-binding protein A or Listeria monocytogenes internalin A can efficiently internalize and deliver DNA in human epithelial cells.

    PubMed

    Innocentin, Silvia; Guimarães, Valeria; Miyoshi, Anderson; Azevedo, Vasco; Langella, Philippe; Chatel, Jean-Marc; Lefèvre, François

    2009-07-01

    Lactococci are noninvasive bacteria frequently used as protein delivery vectors and, more recently, as in vitro and in vivo DNA delivery vehicles. We previously showed that a functional eukaryotic enhanced green fluorescent protein (eGFP) expression plasmid vector was delivered in epithelial cells by Lactococcus lactis producing Listeria monocytogenes internalin A (L. lactis InlA(+)), but this strategy is limited in vivo to transgenic mice and guinea pigs. In this study, we compare the internalization ability of L. lactis InlA(+) and L. lactis producing either the fibronectin-binding protein A of Staphylococcus aureus (L. lactis FnBPA(+)) or its fibronectin binding domains C and D (L. lactis CD(+)). L. lactis FnBPA(+) and L. lactis InlA(+) showed comparable internalization rates in Caco-2 cells, while the internalization rate observed with L. lactis CD(+) was lower. As visualized by conventional and confocal fluorescence microscopy, large clusters of L. lactis FnBPA(+), L. lactis CD(+), and L. lactis InlA(+) were present in the cytoplasm of Caco-2 cells after internalization. Moreover, the internalization rates of Lactobacillus acidophilus NCFM and of an NCFM mutant strain with the gene coding for the fibronectin-binding protein (fbpA) inactivated were also evaluated in Caco-2 cells. Similar low internalization rates were observed for both wild-type L. acidophilus NCFM and the fbpA mutant, suggesting that commensal fibronectin binding proteins have a role in adhesion but not in invasion. L. lactis FnBPA(+), L. lactis CD(+), and L. lactis InlA(+) were then used to deliver a eukaryotic eGFP expression plasmid in Caco-2 cells: flow cytometry analysis showed that the highest percentage of green fluorescent Caco-2 cells was observed after coculture with either L. lactis FnBPA(+) or L. lactis InlA(+). Analysis of the in vivo efficiency of these invasive recombinant strains is currently in progress to validate their potential as DNA vaccine delivery vehicles.

  1. Examination of food chain-derived Listeria monocytogenes strains of different serotypes reveals considerable diversity in inlA genotypes, mutability, and adaptation to cold temperatures.

    PubMed

    Kovacevic, Jovana; Arguedas-Villa, Carolina; Wozniak, Anna; Tasara, Taurai; Allen, Kevin J

    2013-03-01

    Listeria monocytogenes strains belonging to serotypes 1/2a and 4b are frequently linked to listeriosis. While inlA mutations leading to premature stop codons (PMSCs) and attenuated virulence are common in 1/2a, they are rare in serotype 4b. We observed PMSCs in 35% of L. monocytogenes isolates (n = 54) recovered from the British Columbia food supply, including serotypes 1/2a (30%), 1/2c (100%), and 3a (100%), and a 3-codon deletion (amino acid positions 738 to 740) seen in 57% of 4b isolates from fish-processing facilities. Caco-2 invasion assays showed that two isolates with the deletion were significantly more invasive than EGD-SmR (P < 0.0001) and were either as (FF19-1) or more (FE13-1) invasive than a clinical control strain (08-5578) (P = 0.006). To examine whether serotype 1/2a was more likely to acquire mutations than other serotypes, strains were plated on agar with rifampin, revealing 4b isolates to be significantly more mutable than 1/2a, 1/2c, and 3a serotypes (P = 0.0002). We also examined the ability of 33 strains to adapt to cold temperature following a downshift from 37°C to 4°C. Overall, three distinct cold-adapting groups (CAG) were observed: 46% were fast (<70 h), 39% were intermediate (70 to 200 h), and 15% were slow (>200 h) adaptors. Intermediate CAG strains (70%) more frequently possessed inlA PMSCs than did fast (20%) and slow (10%) CAGs; in contrast, 87% of fast adaptors lacked inlA PMSCs. In conclusion, we report food chain-derived 1/2a and 4b serotypes with a 3-codon deletion possessing invasive behavior and the novel association of inlA genotypes encoding a full-length InlA with fast cold-adaptation phenotypes.

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Frerichs, Kimberly Irene

    A greenhouse gas (GHG) inventory is a systematic approach to account for the production and release of certain gases generated by an institution from various emission sources. The gases of interest are those that climate science has identified as related to anthropogenic global climate change. This document presents an inventory of GHGs generated during Fiscal Year (FY) 2014 by Idaho National Laboratory (INL), a Department of Energy (DOE) sponsored entity, located in southeastern Idaho. In recent years, concern has grown about the environmental impact of GHGs. This, together with a desire to decrease harmful environmental impacts, would be enough tomore » encourage the calculation of an inventory of the total GHGs generated at INL. Additionally, INL has a desire to see how its emissions compare with similar institutions, including other DOE national laboratories. Executive Order 13514 requires that federal agencies and institutions document reductions in GHG emissions. INL’s GHG inventory was calculated according to methodologies identified in federal GHG guidance documents using operational control boundaries. It measures emissions generated in three scopes: (1) INL emissions produced directly by stationary or mobile combustion and by fugitive emissions, (2) the share of emissions generated by entities from which INL purchased electrical power, and (3) indirect or shared emissions generated by outsourced activities that benefit INL (occur outside INL’s organizational boundaries, but are a consequence of INL’s activities). This inventory found that INL generated 73,521 metric tons (MT) of CO2 equivalent (CO2e ) emissions during FY14. The following conclusions were made from looking at the results of the individual contributors to INL’s FY14 GHG inventory: • Electricity (including the associated transmission and distribution losses) is the largest contributor to INL’s GHG inventory, with over 50% of the CO2e emissions • Other sources with high emissions were stationary combustion (facility fuels), employee commuting, mobile combustion (fleet fuels), business air travel, and waste disposal (including fugitive emissions from the onsite landfill and contracted disposal) • Sources with low emissions were wastewater treatment (onsite and contracted), business ground travel (in personal and rental vehicles), and fugitive emissions from refrigerants. This report details the methods behind quantifying INL’s GHG inventory and discusses lessons learned on better practices by which information important to tracking GHGs can be tracked and recorded. It is important to note that because this report differentiates between those portions of INL that are managed and operated by Battelle Energy Alliance (BEA) and those managed by other contractors, it includes only the large proportion of Laboratory activities overseen by BEA. It is assumed that other contractors will provide similar reporting for those activities they manage, where appropriate.« less

  3. Job Complexity and Cognitive Performance in Bank Personnel

    DTIC Science & Technology

    1984-09-01

    Hemispheric differences in serial versus parallel processing. Journal of Experimental Psychology 97(3):349-356, 1973. Dumas, R. and Morgan, A. EEG ...7 8 9 10 J_l 12 13 14 15. 16 .17 18 19 20 i 1 n -ifl i 3^1 9 4f^^^ 1 1 M sM^ tM i ’ N eH^^^^H i 1 yllH^^^^I i sH^^^^^^^B ! i...NL Boiling Air Force Base Washington, D.C. 20332 ’ AFHRL/LRS TDC Attn: Susan Ewing Wright-Patterson AFB, OH 45433 Chief, Systems Engineering

  4. INL and NREL Demonstrate Power Grid Simulation at a Distance | News | NREL

    Science.gov Websites

    RTDSs can form a virtual laboratory that allows multiple laboratories to cooperate on energy integration Laboratory (NREL) and Idaho National Laboratory (INL) have successfully demonstrated the capability to within the DOE national laboratory complex. The two national laboratories were able to connect their

  5. INL Director Discusses the Future for Nuclear Energy in the United States

    ScienceCinema

    Grossenbacher, John

    2018-01-15

    Idaho National Laboratory's Director John Grossenbacher explains that the United States should develop its energy policies based on an assessment of the current events at Japan's Fukushima nuclear reactors and the costs and benefits of providing electricity through various energy sources. For more information about INL's nuclear energy research, visit http://www.facebook.com/idahonationallaboratory.

  6. Lighting Studies for Fuelling Machine Deployed Visual Inspection Tool

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stoots, Carl; Griffith, George

    2015-04-01

    Under subcontract to James Fisher Nuclear, Ltd., INL has been reviewing advanced vision systems for inspection of graphite in high radiation, high temperature, and high pressure environments. INL has performed calculations and proof-of-principle measurements of optics and lighting techniques to be considered for visual inspection of graphite fuel channels in AGR reactors in UK.

  7. WATER PUMP HOUSE, TRA619, PUMP INSTALLATION. CAMERA FACING NORTHEAST CORNER. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WATER PUMP HOUSE, TRA-619, PUMP INSTALLATION. CAMERA FACING NORTHEAST CORNER. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON THE ORIGINAL NEGATIVE. INL NEGATIVE NO. 3998. Unknown Photographer, 12/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  8. Computer Program to Add NOISEMAP Grids of Different Spacings

    DTIC Science & Technology

    1980-04-01

    GRIC POINT. C 1,J ARE THE INDICES !-OR THE #-IN’- GRIL , PUINT CLOSLSTP C uUT TO THE LkFT AND 8tLGW9 T~ic Oi.JIRL&j iEIG GkIO POIt4TO C .(1,RJ ARE THE...ACTUAL FLOATING POINT CUORGINATES THE bIG C i.kID POINT WOULD HAVE WERL IT IN THE i-INL GRIL .. C CUMMION /GRIOS/ NBF, NBFL, OG(IOUIOO), dSo FG(iI.0QI,1

  9. PAN AIR - A Computer Program for Predicting Subsonic or Supersonic Linear Potential Flows About Arbitrary Configurations Using a Higher Order Panel Method. Volume II. User’s Manual (Version 1.0).

    DTIC Science & Technology

    1980-05-15

    commercial potential. The FEDD concept was developed as a result of the desire to maintain U.S. leadership in world trade markets and encourage a favorable...normal component of Uo Inl n-- direction shown Onln \\"// corresponds to (c) R * • L " + Onl gives net normal mass flux of amount •U R Onl Figure B.27

  10. Development of Improved Graphical Displays for an Advanced Outage Control Center, Employing Human Factors Principles for Outage Schedule Management

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    St Germain, Shawn Walter; Farris, Ronald Keith; Thomas, Kenneth David

    The long-term viability of existing nuclear power plants in the United States (U.S.) is dependent upon a number of factors, including maintaining high capacity factors, maintaining nuclear safety, and reducing operating costs, particularly those associated with refueling outages. Refueling outages typically take 20-30 days, and for existing light water NPPs in the U.S., the reactor cannot be in operation during the outage. Furthermore, given that many NPPs generate between $1-1.5 million/day in revenue when in operation, there is considerable interest in shortening the length of refueling outages. Yet refueling outages are highly complex operations, involving multiple concurrent and dependent activitiesmore » that are somewhat challenging to coordinate; therefore, finding ways to improve refueling outage performance, while maintaining nuclear safety has proven to be difficult. The Advanced Outage Control Center (AOCC) project is a research and development (R&D) demonstration activity under the LWRS Program. LWRS is an R&D program that works closely with industry R&D programs to establish technical foundations for the licensing and managing of long-term, safe, and economical operation of current fleet of NPPs. As such, the LWRS Advanced Outage Control Center project has the goal of improving the management of commercial NPP refueling outages. To accomplish this goal, INL is developing an advanced outage control center (OCC) that is specifically designed to maximize the usefulness of communication and collaboration technologies for outage coordination and problem resolution activities. The overall focus is on developing an AOCC with the following capabilities that enables plant and OCC staff to; Collaborate in real-time to address emergent issues; Effectively communicate outage status to all workers involved in the outage; Effectively communicate discovered conditions in the field to the OCC; Provide real-time work status; Provide automatic pending support notifications; Provide real-time requirements monitoring; Maximize their collective situational awareness to improve decision-making; and Leverage macro data to better support resource allocation. INL has partnered with several commercial NPP utilities to develop a number of advanced outage management technologies. These outage management technologies have focused on both collaborative technologies for control centers and developing mobile technologies for NPP field workers. This report describes recent efforts made in developing a suite of outage technologies to support more effective schedule management. Currently, a master outage schedule is created months in advance using the plant’s existing scheduling software (e.g., Primavera P6). Typically, during the outage, the latest version of the schedule is printed at the beginning of each shift. INL and its partners are developing technologies that will have capabilities such as Automatic Schedule Updating, Automatic Pending Support Notifications, and the ability to allocate and schedule outage support task resources on a sub-hour basis (e.g., outage Micro-Scheduling). The remaining sections of this report describe in more detail the scheduling challenges that occur during outages, how the outage scheduling technologies INL is developing helps address those challenges, and the latest developments on this task (e.g., work accomplished to date and the path forward)« less

  11. The evaluation of experimental data in fast range for n + 56Fe(n,inl)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Qian, Jing; Herman, M.; Ge, Zhigang

    Iron is one of the five materials selected for evaluation within the pilot international evaluation project CIELO. Analysis of experimental data for n+ 56Fe reaction is the basis for constraining theoretical calculations and eventual creation of the evaluated file. The detail analysis was performed for inelastic cross sections of neutron induced reactions with 56Fe in the fast range up to 20 MeV where there are significant differences among the main evaluated libraries, mainly caused by the different inelastic scattering cross section measurements. Gamma-ray production cross sections provide a way to gain experimental information about the inelastic cross section. Large discrepanciesmore » between experimental data for the 847-keV gamma ray produced in the 56Fe(n,n 1'γ) reaction were analyzed. In addition, experimental data for elastic scattering cross section between 9.41~11 MeV were used to deduce the inelastic cross section from the unitarity constrain.« less

  12. The evaluation of experimental data in fast range for n + 56Fe(n,inl)

    DOE PAGES

    Qian, Jing; Herman, M.; Ge, Zhigang; ...

    2017-09-13

    Iron is one of the five materials selected for evaluation within the pilot international evaluation project CIELO. Analysis of experimental data for n+ 56Fe reaction is the basis for constraining theoretical calculations and eventual creation of the evaluated file. The detail analysis was performed for inelastic cross sections of neutron induced reactions with 56Fe in the fast range up to 20 MeV where there are significant differences among the main evaluated libraries, mainly caused by the different inelastic scattering cross section measurements. Gamma-ray production cross sections provide a way to gain experimental information about the inelastic cross section. Large discrepanciesmore » between experimental data for the 847-keV gamma ray produced in the 56Fe(n,n 1'γ) reaction were analyzed. In addition, experimental data for elastic scattering cross section between 9.41~11 MeV were used to deduce the inelastic cross section from the unitarity constrain.« less

  13. INL Director Discusses Lessons Learned from TMI, Fukushima

    ScienceCinema

    Grossenbacher, John

    2017-12-22

    Idaho National Laboratory's Director John Grossenbacher explains how the U.S. nuclear industry has boosted its safety procedures as a result of the Three Mile Island (TMI) accident in 1979 and how the industry plans to use current events at Japan's Fukushima nuclear plants to further enhance safety. For more information about INL's nuclear energy research, visit http://www.facebook.com/idahonationallaboratory.

  14. Expression of Listeria monocytogenes key virulence genes during growth in liquid medium, on rocket and melon at 4, 10 and 30 °C.

    PubMed

    Hadjilouka, Agni; Molfeta, Christina; Panagiotopoulou, Olga; Paramithiotis, Spiros; Mataragas, Marios; Drosinos, Eleftherios H

    2016-05-01

    The aim of the present study was to assess the expression of key virulence genes, during growth of a Listeria monocytogenes isolate in liquid medium, on melon and rocket at different temperatures and time. For that purpose, BHI broth, rocket and melon were inoculated at 7.0-7.5 log CFU mL(-1) or g(-1)and stored at 4, 10 and 30 °C. Sampling took place upon inoculation and after 0.5, 6 and 24 h of incubation. The RNA was stabilized and the expression of hly, plcA, plcB, sigB, inlA, inlB, inlC, inlJ, lmo2672 and lmo2470 was assessed by RT-qPCR. The results obtained were summarized into two observations; the first one referring to the interactive effect of incubation temperature and type of substrate and the second one to the effect of time on gene expression. Regarding the latter, nearly all genes were regulated upon inoculation and exhibited differential expression in the subsequent sampling times indicating the existence of additional regulatory mechanisms yet to be explored. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Status Report on Activities of the Systems Assessment Task Force, OECD-NEA Expert Group on Accident Tolerant Fuels for LWRs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bragg-Sitton, Shannon Michelle

    The Organization for Economic Cooperation and Development /Nuclear Energy Agency (OECD/NEA) Nuclear Science Committee approved the formation of an Expert Group on Accident Tolerant Fuel (ATF) for LWRs (EGATFL) in 2014. Chaired by Kemal Pasamehmetoglu, INL Associate Laboratory Director for Nuclear Science and Technology, the mandate for the EGATFL defines work under three task forces: (1) Systems Assessment, (2) Cladding and Core Materials, and (3) Fuel Concepts. Scope for the Systems Assessment task force includes definition of evaluation metrics for ATF, technology readiness level definition, definition of illustrative scenarios for ATF evaluation, parametric studies, and selection of system codes. Themore » Cladding and Core Materials and Fuel Concepts task forces will identify gaps and needs for modeling and experimental demonstration; define key properties of interest; identify the data necessary to perform concept evaluation under normal conditions and illustrative scenarios; identify available infrastructure (internationally) to support experimental needs; and make recommendations on priorities. Where possible, considering proprietary and other export restrictions (e.g., International Traffic in Arms Regulations), the Expert Group will facilitate the sharing of data and lessons learned across the international group membership. The Systems Assessment Task Force is chaired by Shannon Bragg-Sitton (INL), while the Cladding Task Force will be chaired by a representative from France (Marie Moatti, Electricite de France [EdF]) and the Fuels Task Force will be chaired by a representative from Japan (Masaki Kurata, Japan Atomic Energy Agency [JAEA]). This report provides an overview of the Systems Assessment Task Force charter and status of work accomplishment.« less

  16. Frequency, virulence genes and antimicrobial resistance of Listeria spp. isolated from bovine clinical mastitis.

    PubMed

    Jamali, Hossein; Radmehr, Behrad

    2013-11-01

    The aims of this study were to determine the prevalence, characteristics and antimicrobial resistance of Listeria spp. isolated from bovine clinical mastitis in Iran. Listeria spp. were detected in 21/207 bovine mastitic milk samples from dairy farms in Iran, comprising L. monocytogenes (n=17), L. innocua (n=3) and L. ivanovii (n=1). L. monocytogenes isolates were grouped into serogroups '4b, 4d, 4e', '1/2a, 3a', '1/2b, 3b, 7' and '1/2c, 3c'; all harboured inlA, inlC and inlJ virulence genes. Listeria spp. were most frequently resistant to penicillin G (14/21 isolates, 66.7%) and tetracyclines (11/21 isolates, 52.4%). Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Definition of Aviation Turbine Fuel Contamination under Simulated Combat Conditions

    DTIC Science & Technology

    1977-09-01

    metals ill a riet system as would quIarttz. The plagio - clase thus con tribiites no0 seven t to ttile test. As a reSU~ti t i A.( . Test O ust reail l...the test package inl that oxides of’ iron. quartz. and mineralls inl thle plagio )Clase feldspar tammiji were idemitt Iitd t’or example, 210 see

  18. DEMINERALIZER BUILDING, TRA608. INSTALLATION OF SAMPLING AND OTHER INSTRUMENTS COMPLETES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DEMINERALIZER BUILDING, TRA-608. INSTALLATION OF SAMPLING AND OTHER INSTRUMENTS COMPLETES DEMINERALIZER UNITS ALONG NORTH WALL. CAMERA FACES EAST. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON THE ORIGINAL NEGATIVE. INL NEGATIVE NO. 3996A. Unknown Photographer, 12/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  19. MTR WING, TRA604. A LABORATORY ROOM WITH ITS CABINETS AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR WING, TRA-604. A LABORATORY ROOM WITH ITS CABINETS AND SERVICE STRIP DOWN CENTER OF ROOM. CARD IN LEFT CORNER OF VIEW WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON THE ORIGINAL NEGATIVE. INL NEGATIVE NO. 3817. Unknown Photographer, 11/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  20. HFE Process Guidance and Standards for potential application to updating NRC guidance

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jacques Hugo; J. J. Persensky

    2012-07-01

    The U.S. Nuclear Regulatory Commission (NRC) reviews and evaluates the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed tomore » the periodic update and improvement of these guidance documents to ensure that they remain state-of-the-art design evaluation tools. Thus, the NRC has initiated a project with BNL to update the NRC guidance to remain current with recent research on human performance, advances in HFE methods and tools, and new technology. INL supported Brookhaven National Lab (BNL) to update the detailed HFE review criteria contained in NUREG-0711 and NUREG-0700 based on (1) feedback obtained from end users, (2) the results of NRC research and development efforts supporting the NRC staff’s HFE safety reviews, and (3) other material the project staff identify as applicable to the update effort. INL submitted comments on development plans and sections of NUREGs 0800, 0711, and 0700. The contractor prepared the report attached here as the deliverable for this work.« less

  1. PIE on Safety-Tested Loose Particles from Irradiated Compact 4-4-2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunn, John D.; Gerczak, Tyler J.; Morris, Robert Noel

    2016-04-01

    Post-irradiation examination (PIE) is being performed in support of tristructural isotropic (TRISO) coated particle fuel development and qualification for High Temperature Gas-cooled Reactors (HTGRs). This work is sponsored by the Department of Energy Office of Nuclear Energy (DOE-NE) through the Advanced Reactor Technologies (ART) Office under the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program. The AGR-1 experiment was the first in a series of TRISO fuel irradiation tests initiated in 2006. The AGR-1 TRISO particles and fuel compacts were fabricated at Oak Ridge National Laboratory (ORNL) in 2006 using laboratory-scale equipment and irradiated for 3 years in themore » Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) to demonstrate and evaluate fuel performance under HTGR irradiation conditions. Post-irradiation examination was performed at INL and ORNL to study how the fuel behaved during irradiation, and to test fuel performance during exposure to elevated temperatures at or above temperatures that could occur during a depressurized conduction cooldown event. This report summarizes safety testing and post-safety testing PIE conducted at ORNL on loose particles extracted from irradiated AGR-1 Compact 4-4-2.« less

  2. Multi-Column Experimental Test Bed Using CaSDB MOF for Xe/Kr Separation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Welty, Amy Keil; Greenhalgh, Mitchell Randy; Garn, Troy Gerry

    Processing of spent nuclear fuel produces off-gas from which several volatile radioactive components must be separated for further treatment or storage. As part of the Off-gas Sigma Team, parallel research at INL and PNNL has produced several promising sorbents for the selective capture of xenon and krypton from these off-gas streams. In order to design full-scale treatment systems, sorbents that are promising on a laboratory scale must be proven under process conditions to be considered for pilot and then full-scale use. To that end, a bench-scale multi-column system with capability to test multiple sorbents was designed and constructed at INL.more » This report details bench-scale testing of CaSDB MOF, produced at PNNL, and compares the results to those reported last year using INL engineered sorbents. Two multi-column tests were performed with the CaSDB MOF installed in the first column, followed with HZ-PAN installed in the second column. The CaSDB MOF column was placed in a Stirling cryocooler while the cryostat was employed for the HZ-PAN column. Test temperatures of 253 K and 191 K were selected for the first column while the second column was held at 191 K for both tests. Calibrated volume sample bombs were utilized for gas stream analyses. At the conclusion of each test, samples were collected from each column and analyzed for gas composition. While CaSDB MOF does appear to have good capacity for Xe, the short time to initial breakthrough would make design of a continuous adsorption/desorption cycle difficult, requiring either very large columns or a large number of smaller columns. Because of the tenacity with which Xe and Kr adhere to the material once adsorbed, this CaSDB MOF may be more suitable for use as a long-term storage solution. Further testing is recommended to determine if CaSDB MOF is suitable for this purpose.« less

  3. Vibro-acoustic Imaging at the Breazeale Reactor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, James Arthur; Jewell, James Keith; Lee, James Edwin

    2016-09-01

    The INL is developing Vibro-acoustic imaging technology to characterize microstructure in fuels and materials in spent fuel pools and within reactor vessels. A vibro-acoustic development laboratory has been established at the INL. The progress in developing the vibro-acoustic technology at the INL is the focus of this report. A successful technology demonstration was performed in a working TRIGA research reactor. Vibro-acoustic imaging was performed in the reactor pool of the Breazeale reactor in late September of 2015. A confocal transducer driven at a nominal 3 MHz was used to collect the 60 kHz differential beat frequency induced in a spentmore » TRIGA fuel rod and empty gamma tube located in the main reactor water pool. Data was collected and analyzed with the INLDAS data acquisition software using a short time Fourier transform.« less

  4. INL receives GreenGov Presidential Award for fleet fuel efficiency improvements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wold, Scott

    Idaho National Laboratory has received a 2010 GreenGov Presidential Award for outstanding achievement in fuel efficiency in its bus and automotive fleets. The award was presented today in Washington, D.C., as part of a three-day symposium on improving sustainability and energy efficiency across the federal government. Lots more content like this is available at INL's facebook page http://www.facebook.com/idahonationallaboratory.

  5. Aerial Flyover of New Research Facilities

    ScienceCinema

    None

    2018-02-14

    The Idaho National Laboratory is focused on continued development of its primary campus areas, including our Idaho Falls campus, to enable the INL to meet DOE expectations as the nations lead nuclear energy laboratory. This video identifies some of the existing Idaho Falls campus facilities and highlights planned and potential future development to support campus growth. You can learn more about INL's energy research projects at http://www.facebook.com/idahonationallaboratory.

  6. INL Director Explains How the National Labs Are Assisting With Japan's Nuclear Crisis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Grossenbacher, John

    2011-04-14

    Idaho National Laboratory's Director John Grossenbacher discusses the types of nuclear expertise and capabilities that exist within the U.S. Department of Energy's national labs to assist with the Japan nuclear crisis. He also explains how the labs will provide long-term research that will uncover lessons learned from the Fukushima nuclear plants. For more information about INL's nuclear energy research, visit http://www.facebook.com/idahonationallaboratory.

  7. INL Multi-Robot Control Interface

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    2005-03-30

    The INL Multi-Robot Control Interface controls many robots through a single user interface. The interface includes a robot display window for each robot showing the robot’s condition. More than one window can be used depending on the number of robots. The user interface also includes a robot control window configured to receive commands for sending to the respective robot and a multi-robot common window showing information received from each robot.

  8. INL Director Explains How the National Labs Are Assisting With Japan's Nuclear Crisis

    ScienceCinema

    Grossenbacher, John

    2018-02-06

    Idaho National Laboratory's Director John Grossenbacher discusses the types of nuclear expertise and capabilities that exist within the U.S. Department of Energy's national labs to assist with the Japan nuclear crisis. He also explains how the labs will provide long-term research that will uncover lessons learned from the Fukushima nuclear plants. For more information about INL's nuclear energy research, visit http://www.facebook.com/idahonationallaboratory.

  9. An update of hydrologic conditions and distribution of selected constituents in water, eastern Snake River Plain aquifer and perched groundwater zones, Idaho National Laboratory, Idaho, emphasis 2012-15

    USGS Publications Warehouse

    Bartholomay, Roy C.; Maimer, Neil V.; Rattray, Gordon W.; Fisher, Jason C.

    2017-04-10

    Since 1952, wastewater discharged to in ltration ponds (also called percolation ponds) and disposal wells at the Idaho National Laboratory (INL) has affected water quality in the eastern Snake River Plain (ESRP) aquifer and perched groundwater zones underlying the INL. The U.S. Geological Survey (USGS), in cooperation with the U.S. Department of Energy, maintains groundwater-monitoring networks at the INL to determine hydrologic trends and to delineate the movement of radiochemical and chemical wastes in the aquifer and in perched groundwater zones. This report presents an analysis of water-level and water-quality data collected from the ESRP aquifer, multilevel monitoring system (MLMS) wells in the ESRP aquifer, and perched groundwater wells in the USGS groundwater monitoring networks during 2012-15.

  10. INL DPAH STAAR 2015 Annual Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peterman, Dean Richard

    2015-09-15

    Research conducted at the INL has demonstrated the synergistic extraction of americium using solvents comprised of bis(o,o-(trifluoromethyl)phenyl) dithiophosphinic acid (DPAH “1”) and trioctylphosphine oxide (TOPO), butyl bis(2,4,4-trimethylpentyl) phosphinate (BuCy272), or dibutyl butylphosphonate (DBBP). One potential drawback of this separations scheme is that soft metals such as silver, cadmium, or palladium and fission products such as zirconium are well extracted by these solvents. Several potential scrubbing reagents were examined. Of the scrubbing reagents studied, cysteine and methione exhibited some ability to scrub soft metals from the loaded solvent. More conventional scrub reagents such as ammonium fluoride or oxalic acid were notmore » effective. Reagents like Bimet and CDTA were not soluble at the acidities used in these studies. Unfortunately, these results indicate that the identification of effective scrubbing reagents for use in a flowsheet based upon the INL DPAH is going to be very difficult.« less

  11. Advanced Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Technical Exchange Meeting

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, Curtis

    2013-09-01

    During FY13, the INL developed an advanced SMR PRA framework which has been described in the report Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Detailed Technical Framework Specification, INL/EXT-13-28974 (April 2013). In this framework, the various areas are considered: Probabilistic models to provide information specific to advanced SMRs Representation of specific SMR design issues such as having co-located modules and passive safety features Use of modern open-source and readily available analysis methods Internal and external events resulting in impacts to safety All-hazards considerations Methods to support the identification of design vulnerabilities Mechanistic and probabilistic data needs to support modelingmore » and tools In order to describe this framework more fully and obtain feedback on the proposed approaches, the INL hosted a technical exchange meeting during August 2013. This report describes the outcomes of that meeting.« less

  12. PINS Testing and Modification for Explosive Identification

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    E.H. Seabury; A.J. Caffrey

    2011-09-01

    The INL's Portable Isotopic Neutron Spectroscopy System (PINS)1 non-intrusively identifies the chemical fill of munitions and sealed containers. PINS is used routinely by the U.S. Army, the Defense Threat Reduction Agency, and foreign military units to determine the contents of munitions and other containers suspected to contain explosives, smoke-generating chemicals, and chemical warfare agents such as mustard and nerve gas. The objects assayed with PINS range from softball-sized M139 chemical bomblets to 200 gallon DOT 500X ton containers. INL had previously examined2 the feasibility of using a similar system for the identification of explosives, and based on this proof-of-principle test,more » the development of a dedicated system for the identification of explosives in an improvised nuclear device appears entirely feasible. INL has been tasked by NNSA NA-42 Render Safe Research and Development with the development of such a system.« less

  13. AGR-1 Thermocouple Data Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jeff Einerson

    2012-05-01

    This report documents an effort to analyze measured and simulated data obtained in the Advanced Gas Reactor (AGR) fuel irradiation test program conducted in the INL's Advanced Test Reactor (ATR) to support the Next Generation Nuclear Plant (NGNP) R&D program. The work follows up on a previous study (Pham and Einerson, 2010), in which statistical analysis methods were applied for AGR-1 thermocouple data qualification. The present work exercises the idea that, while recognizing uncertainties inherent in physics and thermal simulations of the AGR-1 test, results of the numerical simulations can be used in combination with the statistical analysis methods tomore » further improve qualification of measured data. Additionally, the combined analysis of measured and simulation data can generate insights about simulation model uncertainty that can be useful for model improvement. This report also describes an experimental control procedure to maintain fuel target temperature in the future AGR tests using regression relationships that include simulation results. The report is organized into four chapters. Chapter 1 introduces the AGR Fuel Development and Qualification program, AGR-1 test configuration and test procedure, overview of AGR-1 measured data, and overview of physics and thermal simulation, including modeling assumptions and uncertainties. A brief summary of statistical analysis methods developed in (Pham and Einerson 2010) for AGR-1 measured data qualification within NGNP Data Management and Analysis System (NDMAS) is also included for completeness. Chapters 2-3 describe and discuss cases, in which the combined use of experimental and simulation data is realized. A set of issues associated with measurement and modeling uncertainties resulted from the combined analysis are identified. This includes demonstration that such a combined analysis led to important insights for reducing uncertainty in presentation of AGR-1 measured data (Chapter 2) and interpretation of simulation results (Chapter 3). The statistics-based simulation-aided experimental control procedure described for the future AGR tests is developed and demonstrated in Chapter 4. The procedure for controlling the target fuel temperature (capsule peak or average) is based on regression functions of thermocouple readings and other relevant parameters and accounting for possible changes in both physical and thermal conditions and in instrument performance.« less

  14. INFLUENCE NETWORK AGENT EFFECTIVENESS IN PROMOTING COUPLES’ HIV COUNSELING AND TESTING IN KIGALI, RWANDA

    PubMed Central

    Wall, Kristin; Karita, Etienne; Nizam, Azhar; Bekan, Brigitte; Sardar, Gurkiran; Casanova, Debbie; Joseph, Dvora; De Clercq, Freya; Kestelyn, Evelyne; Bayingana, Roger; Tichacek, Amanda; Allen, Susan

    2013-01-01

    Objective To identify predictors of promotion of couples’ voluntary counseling and testing (CVCT) in Kigali, Rwanda Design Analysis of CVCT promotional agent (influential network leaders, INLs; influential network agents, INAs), and couple/invitation-level predictors of CVCT uptake. Methods Number of invitations and couples tested were evaluated by INL, INA, and couple/contextual factors. Multivariable logistic regression accounting for two-level clustering analyzed factors predictive of couples’ testing. Results 26 INLs recruited and mentored 118 INAs who delivered 24,991 invitations. 4,513 couples sought CVCT services after invitation. INAs distributed an average of 212 invitations resulting in an average of 38 couples tested/agent. Characteristics predictive of CVCT in multivariate analyses included the invitee and INA being socially acquainted (aOR=1.4;95%CI:1.2–1.6); invitations delivered after public endorsement (aOR=1.3;95%CI:1.1–1.5); and presence of a mobile testing unit (aOR=1.4;95%CI:1.0–2.0). In stratified analyses, predictors significant among cohabiting couples included invitation delivery to the couple (aOR=1.2;95%CI:1.0–1.4) in the home (aOR=1.3;95%CI:1.1–1.4), while among non-cohabiting couples predictors included invitations given by unemployed INAs (aOR=1.7;95%CI:1.1–2.7). Cohabiting couples with older men were more likely to test, while younger age was associated with testing among men in non-cohabiting unions. Conclusions Invitations distributed by influential people were successful in prompting couples to seek joint HIV testing, particularly if the invitation was given in the home to someone known to the INA, and accompanied by a public endorsement of CVCT. Mobile units also increased the number of couples tested. Country-specific strategies to promote CVCT programs are needed to reduce HIV transmission among those at highest risk for HIV in sub-Saharan Africa. PMID:22008653

  15. An Update of Hydrologic Conditions and Distribution of Selected Constituents in Water, Snake River Plain Aquifer and Perched-Water Zones, Idaho National Laboratory, Idaho, Emphasis 2002-05

    USGS Publications Warehouse

    Davis, Linda C.

    2008-01-01

    Radiochemical and chemical wastewater discharged since 1952 to infiltration ponds, evaporation ponds, and disposal wells at the Idaho National Laboratory (INL) has affected water quality in the Snake River Plain aquifer and perched-water zones underlying the INL. The U.S. Geological Survey, in cooperation with the U.S. Department of Energy, maintains ground-water monitoring networks at the INL to determine hydrologic trends, and to delineate the movement of radiochemical and chemical wastes in the aquifer and in perched-water zones. This report presents an analysis of water-level and water-quality data collected from aquifer and perched-water wells in the USGS ground-water monitoring networks during 2002-05. Water in the Snake River Plain aquifer primarily moves through fractures and interflow zones in basalt, generally flows southwestward, and eventually discharges at springs along the Snake River. The aquifer is recharged primarily from infiltration of irrigation water, infiltration of streamflow, ground-water inflow from adjoining mountain drainage basins, and infiltration of precipitation. From March-May 2001 to March-May 2005, water levels in wells declined throughout the INL area. The declines ranged from about 3 to 8 feet in the southwestern part of the INL, about 10 to 15 feet in the west central part of the INL, and about 6 to 11 feet in the northern part of the INL. Water levels in perched water wells declined also, with the water level dropping below the bottom of the pump in many wells during 2002-05. For radionuclides, concentrations that equal 3s, wheres s is the sample standard deviation, represent a measurement at the minimum detectable concentration, or 'reporting level'. Detectable concentrations of radiochemical constituents in water samples from wells in the Snake River Plain aquifer at the INL generally decreased or remained constant during 2002-05. Decreases in concentrations were attributed to decreased rates of radioactive-waste disposal, radioactive decay, changes in waste-disposal methods, and dilution from recharge and underflow. In October 2005, reportable concentrations of tritium in ground water ranged from 0.51+or-0.12 to 11.5+or-0.6 picocuries per milliliter and the tritium plume extended south-southwestward in the general direction of ground-water flow. Tritium concentrations in water from several wells southwest of the Idaho Nuclear Technology and Engineering Center (INTEC) decreased or remained constant as they had during 1998-2001, with the exception of well USGS 47, which increased a few picocuries per milliliter. Most wells completed in shallow perched water at the Reactor Technology Complex (RTC) were dry during 2002---05. Tritium concentrations in deep perched water exceeded the reporting level in nine wells at the RTC. The tritium concentration in water from one deep perched water well exceeded the reporting level at the INTEC. Concentrations of strontium-90 in water from 14 of 34 wells sampled during October 2005 exceeded the reporting level. Concentrations ranged from 2.2+or-0.7 to 33.1+or-1.2 picocuries per liter. However, concentrations from most wells remained relatively constant or decreased since 1989. Strontium-90 has not been detected within the eastern Snake River Plain aquifer beneath the RTC partly because of the exclusive use of waste-disposal ponds and lined evaporation ponds rather than the disposal well for radioactive-wastewater disposal at RTC. At the RTC, strontium-90 concentrations in water from six wells completed in deep perched ground water exceeded the reporting level during 2002-05. At the INTEC, the reporting level was exceeded in water from three wells completed in deep perched ground water. During 2002-05, concentrations of plutonium-238, and plutonium-239, -240 (undivided), and americium-241 were less than the reporting level in water samples from all wells sampled at the INL. During 2002-05, concentrations of cesium-137 in water from all wells sa

  16. WATER PUMP HOUSE, TRA619, AND TWO WATER STORAGE RESERVOIRS. INDUSTRIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WATER PUMP HOUSE, TRA-619, AND TWO WATER STORAGE RESERVOIRS. INDUSTRIAL WINDOWS AND COPING STRIPS AT TOP OF WALLS AND ENTRY VESTIBULE. BOLLARDS PROTECT UNDERGROUND FACILITIES. SWITCHYARD AT RIGHT EDGE OF VIEW. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON ORIGINAL NEGATIVE. INL NEGATIVE NO. 3816. Unknown Photographer, 11/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  17. Eye Movements and Visual Search: A Bibliography,

    DTIC Science & Technology

    1983-01-01

    Stacey, S.R.; Snyder, H.L. Air-to-air target acquisition: Factors and means of improvement. School of Aerospace Medicine , Brooks AFB, TX, Final Report no...Annual Conference on en6ineerin6 in medicine and biology, Washington , 16-19 November, 1970, p. 136. New York: IEEZ, 1970. EYM, MOD, PSY, CTL 222...HDM, ABN, EYM 242 Freska, C., Ellis, S., Stark, L. Simplified measurement of eye fixation. Computers in Biology and Medicine , 1980. INlS, FIX 243

  18. Operating Experience Review of the INL HTE Gas Monitoring System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    L. C. Cadwallader; K. G. DeWall

    2010-06-01

    This paper describes the operations of several types of gas monitors in use at the Idaho National Laboratory (INL) High Temperature Electrolysis Experiment (HTE) laboratory. The gases monitored at hydrogen, carbon monoxide, carbon dioxide, and oxygen. The operating time, calibration, and unwanted alarms are described. The calibration session time durations are described. Some simple statistics are given for the reliability of these monitors and the results are compared to operating experiences of other types of monitors.

  19. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Demmer, Rick; Fox, Don; Reese, Stephen

    The Idaho National Laboratory (INL) and the United Kingdom (UK) National Nuclear Laboratory (NNL) have been collaborating for several years on materials and methods for the fogged/misted introduction of fixatives into radiologically contaminated facilities. The objective of the project is to deliver a process for reducing airborne radiological and/or mercury contamination and affixing loose contamination in place, thereby reducing contamination risk to employees and decreasing D&D cost and schedule. The developed process provides a reliable, unmanned method of introducing a coating that captures and fixes contamination in place within facilities. The INL coating, termed FX2, has undergone extensive non-radiological testing,more » including determination that it is non-flammable, affixes contamination and flows well through unusual geometries (testing at Florida International University). A series of non-active fogging trials for activity knock/tie-down application have been completed at NNL Workington on behalf of Idaho National Laboratory (INL). These trials performed by the NNL employed commercially available agricultural fogging equipment and the INL’s knock/tie-down latex formulation (FX-2). This testing successfully demonstrated the ability of the fogging devices to successfully spray the FX-2 formulation within various scenarios, and prepared the project for a radioactive trial. The INL has also developed a mercury vapor reducing form of the coating termed FX-Hg, which has shown great promise in laboratory studies.« less

  20. FbpA, a novel multifunctional Listeria monocytogenes virulence factor.

    PubMed

    Dramsi, S; Bourdichon, F; Cabanes, D; Lecuit, M; Fsihi, H; Cossart, P

    2004-07-01

    Listeria monocytogenes is a Gram-positive intracellular bacterium responsible for severe opportunistic infections in humans and animals. Signature-tagged mutagenesis (STM) was used to identify a gene named fbpA, required for efficient liver colonization of mice inoculated intravenously. FbpA was also shown to be required for intestinal and liver colonization after oral infection of transgenic mice expressing human E-cadherin. fbpA encodes a 570-amino-acid polypeptide that has strong homologies to atypical fibronectin-binding proteins. FbpA binds to immobilized human fibronectin in a dose-dependent and saturable manner and increases adherence of wild-type L. monocytogenes to HEp-2 cells in the presence of exogenous fibronectin. Despite the lack of conventional secretion/anchoring signals, FbpA is detected using an antibody generated against the recombinant FbpA protein on the bacterial surface by immunofluorescence, and in the membrane compartment by Western blot analysis of cell extracts. Strikingly, FbpA expression affects the protein levels of two virulence factors, listeriolysin O (LLO) and InlB, but not that of InlA or ActA. FbpA co-immunoprecipitates with LLO and InlB, but not with InlA or ActA. Thus, FbpA, in addition to being a fibronectin-binding protein, behaves as a chaperone or an escort protein for two important virulence factors and appears as a novel multifunctional virulence factor of L. monocytogenes.

  1. The composition of the inner nuclear layer of the cat retina.

    PubMed

    Macneil, Margaret A; Purrier, Sheryl; Rushmore, R Jarrett

    2009-01-01

    The cellular composition of the inner nuclear layer (INL) is largely conserved among mammals. Studies of rabbit, monkey, and mouse retinas have shown that bipolar, amacrine, Müller, and horizontal cells make up constant fractions of the INL (42, 35, 20, and 3%, respectively); these proportions remain relatively constant at all retinal eccentricities. The purpose of our study was to test whether the organization of cat retina is similar to that of other mammalian retinas. Fixed retinas were embedded in plastic, serially sectioned at a thickness of 1 microm, stained, and imaged at high power in the light microscope. Bipolar, amacrine, Müller, and horizontal cells were classified and counted according to established morphological criteria. Additional sets of sections were processed for protein kinase C and calretinin immunoreactivity to determine the relative fraction of rod bipolar and AII amacrine cells. Our results show that the organization of INL in the cat retina contains species-specific alterations in the composition of the INL tied to the large fraction of rod photoreceptors. Compared with other mammalian retinas, cat retinas show an expansion of the rod pathway with rod bipolar cells accounting for about 70% of all bipolar cells and AII cells accounting for nearly a quarter of all amacrine cells. Our results suggest that evolutionary pressures in cats over time have refined their retinal organization to suit its ecological niche.

  2. Enhancements to High Temperature In-Pile Thermocouple Performance

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J.C. Crepeau; J.L. Rempe; J.E. Daw

    2008-03-31

    A joint University of Idaho (UI) and Idaho National Laboratory (INL) University Nuclear Research Initiative (UNERI) was to initiated to extend initial INL efforts to develop doped molybdenum/niobium alloy High Temperature Irradiation Resistant Thermocouples (HTIR-TCs). The overall objective of this UNERI was to develop recommendations for an optimized thermocouple design for high temperature, long duration, in-pile testing by expanding upon results from initial INL efforts. Tasks to quantify the impact of candidate enhancements, such as alternate alloys, alternate geometries, and alternate thermocouple fabrication techniques, on thermocouple performance were completed at INL's High Temperature Test Laboratory (HTTL), a state of themore » art facility equipped with specialized equipment and trained staff in the area of high temperature instrumentation development and evaluation. Key results of these evaluations, which are documented in this report, are as follows. The doped molybdenum and Nb-1%Zr, which were proposed in the initial INL HTIR-TC design, were found to retain ductility better than the developmental molybdenum-low niobium alloys and the niobium-low molybdenum alloys evaluated. Hence, the performance and lower cost of the commercially available KW-Mo makes a thermocouple containing KW-Mo and Nb-1%Zr the best option at this time. HTIR-TCs containing larger diameter wires offer the potential to increase HTIR-TC stability and reliability at higher temperatures. HTIR-TC heat treatment temperatures and times should be limited to not more than 100 C above the proposed operating temperatures and to durations of at least 4 to 5 hours. Preliminary investigations suggest that the performance of swaged and loose assembly HTIR-TC designs is similar. However, the swaged designs are less expensive and easier to construct. In addition to optimizing HTIR-TC performance, This UNERI project provided unique opportunities to several University of Idaho students, allowing them to become familiar with the techniques and equipment used for specialized high temperature instrumentation fabrication and evaluation and to author/coauthor several key conference papers and journal articles.« less

  3. Enhancements to High Temperature In-Pile Thermocouple Performance

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J. C. Crepeau; J. L. Rempe; J. E. Daw

    2008-03-01

    A joint University of Idaho (UI) and Idaho National Laboratory (INL) University Nuclear Research Initiative (UNERI) was to initiated to extend initial INL efforts to develop doped lybdenum/niobium alloy High Temperature Irradiation Resistant Thermocouples (HTIR-TCs). The overall objective of this UNERI was to develop recommendations for an optimized thermocouple design for high temperature, long duration, in-pile testing by expanding upon results from initial INL efforts. Tasks to quantify the impact of candidate enhancements, such as alternate alloys, alternate geometries, and alternate thermocouple fabrication techniques, on thermocouple performance were completed at INL's High Temperature Test Laboratory (HTTL), a state of themore » art facility equipped with specialized equipment and trained staff in the area of high temperature instrumentation development and evaluation. Key results of these evaluations, which are documented in this report, are as follows. The doped molybdenum and Nb-1%Zr, which were proposed in the initial INL HTIR-TC design, were found to retain ductility better than the developmental molybdenum-low niobium alloys and the niobium-low molybdenum alloys evaluated. Hence, the performance and lower cost of the commercially available KW-Mo makes a thermocouple containing KW-Mo and Nb-1%Zr the best option at this time. HTIR-TCs containing larger diameter wires offer the potential to increase HTIR-TC stability and reliability at higher temperatures. HTIR-TC heat treatment temperatures and times should be limited to not more than 100 °C above the proposed operating temperatures and to durations of at least 4 to 5 hours. Preliminary investigations suggest that the performance of swaged and loose assembly HTIR-TC designs is similar. However, the swaged designs are less expensive and easier to construct. In addition to optimizing HTIR-TC performance, This UNERI project provided unique opportunities to several University of Idaho students, allowing them to become familiar with the techniques and equipment used for specialized high temperature instrumentation fabrication and evaluation and to author/coauthor several key conference papers and journal articles.« less

  4. Hearing Protection Evaluation for the Combat Arms Earplug at Idaho National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    James Lovejoy

    2007-03-01

    The Idaho National Laboratory (INL) is managed by Battelle Energy Alliance, LLC (BEA) for the Department of Energy. The INL Protective Security Forces (Pro Force) are involved in training exercises that generate impulse noise by small arms fire. Force-on-force (FOF) training exercises that simulate real world scenarios require the Pro Force to engage the opposition force (OPFOR) while maintaining situational awareness through verbal communications. The Combat Arms earplug was studied to determine if it provides adequate hearing protection in accordance with the requirements of MIL-STD-1474C/D. The Combat Arms earplug uses a design that allows continuous noise through a critical orificemore » while effectively attenuating high-energy impulse noise. The earplug attenuates noise on a non linear scale, as the sound increases the attenuation increases. The INL studied the effectiveness of the Combat Arms earplug with a Bruel & Kjaer (B&K) head and torso simulator used with a selection of small arms to create impulse sound pressures. The Combat Arms earplugs were inserted into the B&K head and torso ears, and small arms were then discharged to generate the impulse noise. The INL analysis of the data indicates that the Combat Arms earplug does provide adequate protection, in accordance with MIL-STD-1474C/D, when used to protect against impulse noise generated by small arms fire using blank ammunition. Impulse noise generated by small arms fire ranged from 135–160 dB range unfiltered un-weighted. The Combat Arms earplug attenuated the sound pressure 10–25 dB depending on the impulse noise pressure. This assessment is consistent with the results of previously published studies on the Combat Arms earplug (see Section 5, “References”). Based upon these result, the INL intends to use the Combat Arms earplug for FOF training exercises.« less

  5. High Temperature Electrolysis for Hydrogen Production from Nuclear Energy – TechnologySummary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J. E. O'Brien; C. M. Stoots; J. S. Herring

    2010-02-01

    The Department of Energy, Office of Nuclear Energy, has requested that a Hydrogen Technology Down-Selection be performed to identify the hydrogen production technology that has the best potential for timely commercial demonstration and for ultimate deployment with the Next Generation Nuclear Plant (NGNP). An Independent Review Team has been assembled to execute the down-selection. This report has been prepared to provide the members of the Independent Review Team with detailed background information on the High Temperature Electrolysis (HTE) process, hardware, and state of the art. The Idaho National Laboratory has been serving as the lead lab for HTE research andmore » development under the Nuclear Hydrogen Initiative. The INL HTE program has included small-scale experiments, detailed computational modeling, system modeling, and technology demonstration. Aspects of all of these activities are included in this report. In terms of technology demonstration, the INL successfully completed a 1000-hour test of the HTE Integrated Laboratory Scale (ILS) technology demonstration experiment during the fall of 2008. The HTE ILS achieved a hydrogen production rate in excess of 5.7 Nm3/hr, with a power consumption of 18 kW. This hydrogen production rate is far larger than has been demonstrated by any of the thermochemical or hybrid processes to date.« less

  6. FY 2014 LDRD Annual Report Project Summaries

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tomchak, Dena

    The FY 2014 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support future DOE missions and national research priorities. LDRD is essential to INL - it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enahnces technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

  7. Idaho National Laboratory Quarterly Performance Analysis - 2nd Quarter FY2014

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lisbeth A. Mitchell

    2014-06-01

    This report is published quarterly by the Idaho National Laboratory (INL) Performance Assurance Organization. The Department of Energy Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of occurrence reports and other deficiency reports (including not reportable events) identified at INL from January 2014 through March 2014.

  8. An Assessment of Aquifer/Well Flow Dynamics: Identification of Parameters Key to Passive Sampling and Application of Downhole Sensor Technologies

    DTIC Science & Technology

    2014-12-01

    Simulated Solute Transport in a Numerical Replication of Britt’s 2005 Experiment Figure 44 In-Well Flow Inhibitor Figure 45 Results of a Preliminary Dye ...Tracer Experiment Conducted at INL Figure 46 Results Horizontally-Oriented Dye Tracer Experiment Conducted at INL ER-1704 Final Report 2014 vii...possible sources of well convection and mixing. Specifically, the modeling explored: • 2D and 3D physical tank models. Dye tracer testing was conducted

  9. Operating experience review of an INL gas monitoring system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cadwallader, Lee C.; DeWall, K. G.; Herring, J. S.

    2015-03-12

    This article describes the operations of several types of gas monitors in use at the Idaho National Laboratory (INL) High Temperature Electrolysis Experiment (HTE) laboratory. The gases monitored in the lab room are hydrogen, carbon monoxide, carbon dioxide, and oxygen. The operating time, calibration, and both actual and unwanted alarms are described. The calibration session time durations are described. In addition, some simple calculations are given to estimate the reliability of these monitors and the results are compared to operating experiences of other types of monitors.

  10. DEMINERALIZER BUILDING,TRA608. CAMERA FACES EAST ALONG SOUTH WALL. INSTRUMENT PANEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DEMINERALIZER BUILDING,TRA-608. CAMERA FACES EAST ALONG SOUTH WALL. INSTRUMENT PANEL BOARD IS IN RIGHT HALF OF VIEW, WITH FOUR PUMPS BEYOND. SMALLER PUMPS FILL DEMINERALIZED WATER TANK ON SOUTH SIDE OF BUILDING. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON ORIGINAL NEGATIVE. INL NEGATIVE NO. 3997A. Unknown Photographer, 12/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  11. An overview of research activities on materials for nuclear applications at the INL Safety, Tritium and Applied Research facility

    NASA Astrophysics Data System (ADS)

    Calderoni, P.; Sharpe, J.; Shimada, M.; Denny, B.; Pawelko, B.; Schuetz, S.; Longhurst, G.; Hatano, Y.; Hara, M.; Oya, Y.; Otsuka, T.; Katayama, K.; Konishi, S.; Noborio, K.; Yamamoto, Y.

    2011-10-01

    The Safety, Tritium and Applied Research facility at the Idaho National Laboratory is a US Department of Energy National User Facility engaged in various aspects of materials research for nuclear applications related to fusion and advanced fission systems. Research activities are mainly focused on the interaction of tritium with materials, in particular plasma facing components, liquid breeders, high temperature coolants, fuel cladding, cooling and blanket structures and heat exchangers. Other activities include validation and verification experiments in support of the Fusion Safety Program, such as beryllium dust reactivity and dust transport in vacuum vessels, and support of Advanced Test Reactor irradiation experiments. This paper presents an overview of the programs engaged in the activities, which include the US-Japan TITAN collaboration, the US ITER program, the Next Generation Power Plant program and the tritium production program, and a presentation of ongoing experiments as well as a summary of recent results with emphasis on fusion relevant materials.

  12. Workplace slip, trip and fall injuries and obesity.

    PubMed

    Koepp, Gabriel A; Snedden, Bradley J; Levine, James A

    2015-01-01

    The objective of this study was to examine the relationship between slip, trip and fall injuries and obesity in a population of workers at the Idaho National Laboratory (INL) in Idaho Falls, Idaho. INL is an applied engineering facility dedicated to supporting the US Department of Energy's mission. An analysis was performed on injuries reported to the INL Medical Clinic to determine whether obesity was related to an increase in slip, trip and fall injuries. Records were analysed that spanned a 6-year period (2005-2010), and included 8581 employees (mean age, 47 ± 11 years and body mass index [BMI], 29 ± 5 kg/m(2); 34% obesity rate). Of the 189 people who reported slip, trip and fall injuries (mean age, 48 ± 11 years), 51% were obese (P < 0.001 compared with uninjured employees), and their mean BMI was 31 ± 6 kg/m(2) (P < 0.001). Obesity in this population was associated with a greater rate of slip, trip and fall injuries.

  13. CTBTO Contractor Laboratory Test Sample Production Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bob Hague; Tracy Houghton; Nick Mann

    2013-08-01

    In October 2012 scientists from both Idaho National Laboratory (INL) and the CTBTO contact laboratory at Seibersdorf, Austria designed a system and capability test to determine if the INL could produce and deliver a short lived radio xenon standard in time for the standard to be measured at the CTBTO contact laboratory at Seibersdorf, Austria. The test included sample standard transportation duration and potential country entrance delays at customs. On October 23, 2012 scientists at the Idaho National Laboratory (INL) prepared and shipped a Seibersdorf contract laboratory supplied cylinder. The canister contained 1.0 scc of gas that consisted of 70%more » xenon and 30% nitrogen by volume. The t0 was October 24, 2012, 1200 ZULU. The xenon content was 0.70 +/ 0.01 scc at 0 degrees C. The 133mXe content was 4200 +/ 155 dpm per scc of stable xenon on t0 (1 sigma uncertainty). The 133Xe content was 19000 +/ 800 dpm per scc of stable xenon on t0 (1 sigma uncertainty).« less

  14. Genetic Characterization of Listeria monocytogenes Isolates from Industrial and Retail Ready-to-Eat Meat-Based Foods and Their Relationship with Clinical Strains from Human Listeriosis in Portugal.

    PubMed

    Henriques, A R; Cristino, J Melo; Fraqueza, M J

    2017-04-01

    Listeria monocytogenes isolates (n = 81) recovered from ready-to-eat meat-based food products (RTEMP) collected in industrial processing plants and retail establishments were genetically characterized for comparison with those from human clinical cases of listeriosis (n = 49). The aim was to assess RTEMP as a possible food source for human infection. L. monocytogenes was detected in 12.5% of the RTEMP samples, and in some cases, counts were above the European food safety criteria. All isolates were assessed by multiplex PCR for serogroup determination and detection of virulence-associated genes inlA, inlB, inlC, inlJ, plcA, hlyA, actA, and iap. Serogroups IIb and IVb dominated in RTEMP and human isolates, and all were positive for the assessed virulence genes. Antibiotic susceptibility testing by the disk diffusion method revealed a low level of resistance among the isolates. Pulsed-field gel electrophoresis (PFGE) of L. monocytogenes isolates, using restriction enzymes ApaI and AscI, revealed genetic variability and differentiated the isolates in five clusters. Although some pulsed-field gel electrophoresis profiles of particular RTEMP and human isolates seemed to be highly related, exhibiting more than 90% similarity, which suggests a possible common source, in most cases the strains were not genetically or temporally matched. The close genetic relatedness of RTEMP and human listeriosis strains stressed the importance of preventive measure implementation throughout the food chain.

  15. Developing Government Renewable Energy Projects

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kurt S. Myers; Thomas L. Baldwin; Jason W. Bush

    The US Army Corps of Engineers has retained Idaho National Laboratory (INL) to conduct a study of past INL experiences and complete a report that identifies the processes that are needed for the development of renewable energy projects on government properties. The INL has always maintained expertise in power systems and applied engineering and INL’s renewable energy experiences date back to the 1980’s when our engineers began performing US Air Force wind energy feasibility studies and development projects. Over the last 20+ years of working with Department of Defense and other government agencies to study, design, and build government renewablemore » projects, INL has experienced the do’s and don’ts for being successful with a project. These compiled guidelines for government renewable energy projects could include wind, hydro, geothermal, solar, biomass, or a variety of hybrid systems; however, for the purpose of narrowing the focus of this report, wind projects are the main topic discussed throughout this report. It is our thought that a lot of what is discussed could be applied, possibly with some modifications, to other areas of renewable energy. It is also important to note that individual projects (regardless the type) vary to some degree depending on location, size, and need but in general these concepts and directions can be carried over to the majority of government renewable energy projects. This report focuses on the initial development that needs to occur for any project to be a successful government renewable energy project.« less

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    McLing, Travis; Carpenter, Michael; Brandon, William

    The Environmental Protection Agency (EPA) has teamed with Battelle Energy Alliance, LLC (BEA) at Idaho National Laboratory (INL) to facilitate further testing of geologic-fracture-identification methodology at a field site near the Monsanto Superfund Site located in Soda Springs, Idaho. INL has the necessary testing and technological expertise to perform this work. Battelle Memorial Institute (BMI) has engaged INL to perform this work through a Work for Others (WFO) Agreement. This study continues a multi-year collaborative effort between INL and EPA to test the efficacy of using field deployed Cr-39 radon in soil portals. This research enables identification of active fracturesmore » capable of transporting contaminants at sites where fractures are suspected pathways into the subsurface. Current state of the art methods for mapping fracture networks are exceedingly expensive and notoriously inaccurate. The proposed WFO will evaluate the applicability of using cheap, readily available, passive radon detectors to identify conductive geologic structures (i.e. fractures, and fracture networks) in the subsurface that control the transport of contaminants at fracture-dominated sites. The proposed WFO utilizes proven off-the-shelf technology in the form of CR-39 radon detectors, which have been widely deployed to detect radon levels in homes and businesses. In an existing collaborative EPA/INL study outside of this workscope,. CR-39 detectors are being utilized to determine the location of active transport fractures in a fractured granitic upland adjacent to a landfill site at the Fort Devens, MA that EPA-designated as National Priorities List (NPL) site. The innovative concept of using an easily deployed port that allows the CR-39 to measure the Rn-222 in the soil or alluvium above the fractured rock, while restricting atmospheric Rn-222 and soil sourced Ra from contaminating the detector is unique to INL and EPA approach previously developed. By deploying a series of these inexpensive detector-casing combinations statistical samples of the Rn-222 flux can be measured, elucidating the most communicative fractures (i.e. fractures that are actively transporting water and gasses). The Rn-222 measurements can then be used as an input to create a more accurate conceptual model to be used for transport modeling and related cleanup activities. If the team’s approach is demonstrated to be applicable to a wide variety of rock types and soil conditions it might potentially offer significant cost saving without a reduction in data quality at Monsanto Superfund and other sites underlain by fracture-dominated bedrock.« less

  17. Laboratory Directed Research and Development FY-10 Annual Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dena Tomchak

    2011-03-01

    The FY 2010 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support the future DOE missions and national research priorities. LDRD is essential to the INL -- it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enhances technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

  18. Arundo Donax Analysis Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Corrie I. Nichol, Ph.D.; Tyler L. Westover, Ph.D.

    This is a summary report of preliminary analysis conducted on Arundo Donax. Arundo Donax was received from Greenwood Resources via Portland General Electric. PGE plans to transition a coal-fired boiler to 100% biomass by 2020, and has partnered with EPRI and INL to conduct the necessary testing and development to understand what needs to take place to make this transition. Arundo Donax is a promising energy crop for biopower, and is as yet relatively untested and uncharacterized. The INL has begun initial characterization of this material, and this summary report presents the initial findings.

  19. DC Fast Charger Usage in the Pacific Northwest

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Salisbury, Shawn; Smart, John

    2015-02-01

    This document will describe the use of a number of Direct Current Fast Charging Stations throughout Washington and Oregon as a part of of the West Coast Electric Highway. It will detail the usage frequency and location of the charging stations INL has data from. It will also include aggregated data from hundreds of privately owned vehicles that were enrolled in the EV Project regarding driving distance when using one of the West Coast Electric Highway fast chargers. This document is a white paper that will be published on the INL AVTA website.

  20. Idaho National Laboratory Quarterly Event Performance Analysis FY 2013 4th Quarter

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitchell, Lisbeth A.

    2013-11-01

    This report is published quarterly by the Idaho National Laboratory (INL) Performance Assurance Organization. The Department of Energy Occurrence Reporting and Processing System (ORPS) as prescribed in DOE Order 232.2 “Occurrence Reporting and Processing of Operations Information” requires a quarterly analysis of events, both reportable and not reportable for the previous twelve months. This report is the analysis of occurrence reports and deficiency reports (including not reportable events) identified at the Idaho National Laboratory (INL) during the period of October 2012 through September 2013.

  1. Chemical constituents in groundwater from multiple zones in the eastern Snake River Plain aquifer, Idaho National Laboratory, Idaho, 2009-13

    USGS Publications Warehouse

    Bartholomay, Roy C.; Hopkins, Candice B.; Maimer, Neil V.

    2015-01-01

    Tritium concentrations in relation to basaltic flow units indicate the presence of wastewater influence in multiple basalt flow groups; however, tritium is most abundant in the South Late Matuyama flow group in the southern boundary wells. The concentrations of wastewater constituents in deep zones in wells Middle 2051, USGS 132, USGS 105, and USGS 103 support the concept of groundwater flow deepening in the southwestern corner of the INL, as indicated by the INL groundwater-flow model.

  2. Automated Work Package: Initial Wireless Communication Platform Design, Development, and Evaluation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Al Rashdan, Ahmad Yahya Mohammad; Agarwal, Vivek

    The Department of Energy’s Light Water Reactor Sustainability Program is developing the scientific basis to ensure long-term reliability, productivity, safety, and security of the nuclear power industry in the United States. The Instrumentation, Information, and Control (II&C) pathway of the program aims to increase the role of advanced II&C technologies to achieve this objective. One of the pathway efforts at Idaho National Laboratory (INL) is to improve the work packages execution process by replacing the expensive, inefficient, bulky, complex, and error-prone paper-based work orders with automated work packages (AWPs). An AWP is an automated and dynamic presentation of the workmore » package designed to guide the user through the work process. It is loaded on a mobile device, such as a tablet, and is capable of communicating with plant equipment and systems to acquire plant and procedure states. The AWP replaces those functions where a computer is more efficient and reliable than a human. To enable the automatic acquisition of plant data, it is necessary to design and develop a prototype platform for data exchange between the field instruments and the AWP mobile devices. The development of the platform aims to reveal issues and solutions generalizable to large-scale implementation of a similar system. Topics such as bandwidth, robustness, response time, interference, and security are usually associated with wireless communication. These concerns, along with other requirements, are listed in an earlier INL report. Specifically, the targeted issues and performance aspects in this work are relevant to the communication infrastructure from the perspective of promptness, robustness, expandability, and interoperability with different technologies.« less

  3. Advanced Fuel Cycle Cost Basis – 2017 Edition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dixon, B. W.; Ganda, F.; Williams, K. A.

    This report, commissioned by the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), provides a comprehensive set of cost data supporting a cost analysis for the relative economic comparison of options for use in the DOE Nuclear Technology Research and Development (NTRD) Program (previously the Fuel Cycle Research and Development (FCRD) and the Advanced Fuel Cycle Initiative (AFCI)). The report describes the NTRD cost basis development process, reference information on NTRD cost modules, a procedure for estimating fuel cycle costs, economic evaluation guidelines, and a discussion on the integration of cost data into economic computer models. This reportmore » contains reference cost data for numerous fuel cycle cost modules (modules A-O) as well as cost modules for a number of reactor types (R modules). The fuel cycle cost modules were developed in the areas of natural uranium mining and milling, thorium mining and milling, conversion, enrichment, depleted uranium disposition, fuel fabrication, interim spent fuel storage, reprocessing, waste conditioning, spent nuclear fuel (SNF) packaging, long-term monitored retrievable storage, managed decay storage, recycled product storage, near surface disposal of low-level waste (LLW), geologic repository and other disposal concepts, and transportation processes for nuclear fuel, LLW, SNF, transuranic, and high-level waste. Since its inception, this report has been periodically updated. The last such internal document was published in August 2015 while the last external edition was published in December of 2009 as INL/EXT-07-12107 and is available on the Web at URL: www.inl.gov/technicalpublications/Documents/4536700.pdf. This current report (Sept 2017) is planned to be reviewed for external release, at which time it will replace the 2009 report as an external publication. This information is used in the ongoing evaluation of nuclear fuel cycles by the NE NTRD program.« less

  4. An update of hydrologic conditions and distribution of selected constituents in water, Snake River Plain aquifer, Idaho National Laboratory, Idaho, Emphasis 1999-2001

    USGS Publications Warehouse

    Davis, Linda C.

    2006-01-01

    Radiochemical and chemical wastewater discharged since 1952 to infiltration ponds, evaporation ponds, and disposal wells at the Idaho National Laboratory (INL) has affected water quality in the Snake River Plain aquifer underlying the INL. The U.S. Geological Survey (USGS), in cooperation with the U.S. Department of Energy, maintains ground-water monitoring networks at the INL to determine hydrologic trends, and to delineate the movement of radiochemical and chemical wastes in the aquifer. This report presents an analysis of water-level and water-quality data collected from wells in the USGS ground-water monitoring networks during 1999-2001. Water in the Snake River Plain aquifer moves principally through fractures and interflow zones in basalt, generally flows southwestward, and eventually discharges at springs along the Snake River. The aquifer is recharged principally from infiltration of irrigation water, infiltration of streamflow, ground-water inflow from adjoining mountain drainage basins, and infiltration of precipitation. Water levels in wells rose in the northern and west-central parts of the INL by 1 to 3 feet, and declined in the southwestern parts of the INL by up to 4 feet during 1999-2001. Detectable concentrations of radiochemical constituents in water samples from wells in the Snake River Plain aquifer at the INL generally decreased or remained constant during 1999-2001. Decreases in concentrations were attributed to decreased rates of radioactive-waste disposal, radioactive decay, changes in waste-disposal methods, and dilution from recharge. Tritium concentrations in water samples decreased as much as 8.3 picocuries per milliliter (pCi/mL) during 1999-2001, ranging from 0.43?0.14 to 13.6?0.6 pCi/mL in October 2001. Tritium concentrations in five wells near the Idaho Nuclear Technology and Engineering Center (INTEC) increased a few picocuries per milliliter from October 2000 to October 2001. Strontium-90 concentrations decreased or remained constant during 1999-2001, ranging from 2.1?0.6 to 42.4?1.4 pCi/L in October 2001. During 1999-2001, concentrations of cesium-137, plutonium-238, and plutonium-239, -240 (undivided) were less than the reporting level in water samples from all wells sampled at the INL. The concentration of americium-241 in one sample was 0.003?0.001 pCi/L, the reporting level for that constituent. Cobalt-60 was not detected in any samples collected during 1999-2001. Changes in detectable concentrations of nonradioactive chemical constituents in water from the Snake River Plain aquifer at the INL varied during 1999-2001. In October 2001, water from one well south of the Reactor Technology Complex (RTC) [known as the Test Reactor Area (TRA) until 2005] contained 139 micrograms per liter (?g/L) of chromium, a decrease from the concentration of 168 ?g/L detected in October 1998. Other water samples contained from less than 16.7 to 21.3 ?g/L of chromium. In October 2001, concentrations of sodium in water samples from most of the wells in the southern part of the INL were larger than the background concentration of 10 mg/L, but were similar to or slightly less than October 1998 concentrations. The largest sodium concentration was 75 milligrams per liter (mg/L) in water from well USGS 113. In 2001, chloride concentrations in most water samples from the INTEC and the Central Facilities Area (CFA) exceeded ambient concentrations of 10 and 20 mg/L, respectively. Chloride concentrations in water from wells near the RTC were less than 20 mg/L. At the Radioactive Waste Management Complex (RWMC), chloride concentrations in water from wells USGS 88, 89, and 120 were 81, 40, and 23 mg/L, respectively. Concentrations of chloride in all other wells near the RWMC were less than 19 mg/L. During 2001, concentrations of sulfate in water from two wells near the RTC, two wells near the RWMC, and one well near the CFA exceeded 40 mg/L, the estimated background concentration of sulfate in the Snake River

  5. Quantitative Assessment of Detection Frequency for the INL Ambient Air Monitoring Network

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sondrup, A. Jeffrey; Rood, Arthur S.

    A quantitative assessment of the Idaho National Laboratory (INL) air monitoring network was performed using frequency of detection as the performance metric. The INL air monitoring network consists of 37 low-volume air samplers in 31 different locations. Twenty of the samplers are located on INL (onsite) and 17 are located off INL (offsite). Detection frequencies were calculated using both BEA and ESER laboratory minimum detectable activity (MDA) levels. The CALPUFF Lagrangian puff dispersion model, coupled with 1 year of meteorological data, was used to calculate time-integrated concentrations at sampler locations for a 1-hour release of unit activity (1 Ci) formore » every hour of the year. The unit-activity time-integrated concentration (TICu) values were calculated at all samplers for releases from eight INL facilities. The TICu values were then scaled and integrated for a given release quantity and release duration. All facilities modeled a ground-level release emanating either from the center of the facility or at a point where significant emissions are possible. In addition to ground-level releases, three existing stacks at the Advanced Test Reactor Complex, Idaho Nuclear Technology and Engineering Center, and Material and Fuels Complex were also modeled. Meteorological data from the 35 stations comprising the INL Mesonet network, data from the Idaho Falls Regional airport, upper air data from the Boise airport, and three-dimensional gridded data from the weather research forecasting model were used for modeling. Three representative radionuclides identified as key radionuclides in INL’s annual National Emission Standards for Hazardous Air Pollutants evaluations were considered for the frequency of detection analysis: Cs-137 (beta-gamma emitter), Pu-239 (alpha emitter), and Sr-90 (beta emitter). Source-specific release quantities were calculated for each radionuclide, such that the maximum inhalation dose at any publicly accessible sampler or the National Emission Standards for Hazardous Air Pollutants maximum exposed individual location (i.e., Frenchman’s Cabin) was no more than 0.1 mrem yr–1 (i.e., 1% of the 10 mrem yr–1 standard). Detection frequencies were calculated separately for the onsite and offsite monitoring network. As expected, detection frequencies were generally less for the offsite sampling network compared to the onsite network. Overall, the monitoring network is very effective at detecting the potential releases of Cs-137 or Sr-90 from all sources/facilities using either the ESER or BEA MDAs. The network was less effective at detecting releases of Pu-239. Maximum detection frequencies for Pu-239 using ESER MDAs ranged from 27.4 to 100% for onsite samplers and 3 to 80% for offsite samplers. Using BEA MDAs, the maximum detection frequencies for Pu-239 ranged from 2.1 to 100% for onsite samplers and 0 to 5.9% for offsite samplers. The only release that was not detected by any of the samplers under any conditions was a release of Pu-239 from the Idaho Nuclear Technology and Engineering Center main stack (CPP-708). The methodology described in this report could be used to improve sampler placement and detection frequency, provided clear performance objectives are defined.« less

  6. CO2 Separation Using Thermally Optimized Membranes: A Comprehensive Project Report (2000 - 2007)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J.R. Klaehn; C.J. Orme; E.S. Peterson

    2008-03-01

    This is a complete (Fiscal Years 2000–2006) collection of the Idaho National Laboratory’s (INL) research and development contributions to the project, “CO2 Separation Using Thermally Optimized Membranes.” The INL scientific contribution to the project has varied due to the fluctuations in funding from year to year. The focus of the project was polybenzimidazole (PBI) membranes and developing PBI compounds (both substitution and blends) that provide good film formation and gas separation membranes. The underlying problem with PBI is its poor solubility in common solvents. Typically, PBI is dissolved in “aggressive” solvents, like N,N-dimethylacetamide (DMAc) and N methylpyrrolidone (NMP). The INLmore » FY-03 research was directed toward making soluble N-substituted PBI polymers, where INL was very successful. Many different types of modified PBI polymers were synthesized; however, film formation proved to be a big problem with both unsubstituted and N-substituted PBIs. Therefore, INL researchers directed their attention to using plasticizers or additives to make the membranes more stable and workable. During the course of these studies, other high-performance polymers (like polyamides and polyimides) were found to be better materials, which could be used either by themselves or blends with PBI. These alternative high-performance polymers provided the best pathway forward for soluble high-temperature polymers with good stable film formation properties. At present, the VTEC polyimides (product of RBI, Inc.) are the best film formers that exhibit high-temperature resistance. INL’s gas testing results show VTEC polyimides have very good gas selectivities for both H2/CO2 and CO2/CH4. Overall, these high-performance polymers pointed towards new research areas where INL has gained a greater understanding of polymer film formation and gas separation. These studies are making possible a direct approach to stable polymer-based high-temperature gas separation membranes. This report is separated into several sections due to the complexity of the research and the variation with the development of better high-temperature, gas separation membranes. Several fiscal years are combined because the research and development efforts within those areas crossed fiscal year boundaries.« less

  7. CO2 Separation Using Thermally Optimized Membranes: A Comprehensive Project Report (2000 - 2007)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    N /A

    2008-03-04

    This is a complete (Fiscal Years 2000–2006) collection of the Idaho National Laboratory’s (INL) research and development contributions to the project, “CO2 Separation Using Thermally Optimized Membranes.” The INL scientific contribution to the project has varied due to the fluctuations in funding from year to year. The focus of the project was polybenzimidazole (PBI) membranes and developing PBI compounds (both substitution and blends) that provide good film formation and gas separation membranes. The underlying problem with PBI is its poor solubility in common solvents. Typically, PBI is dissolved in “aggressive” solvents, like N,N-dimethylacetamide (DMAc) and N methylpyrrolidone (NMP). The INLmore » FY-03 research was directed toward making soluble N-substituted PBI polymers, where INL was very successful. Many different types of modified PBI polymers were synthesized; however, film formation proved to be a big problem with both unsubstituted and N-substituted PBIs. Therefore, INL researchers directed their attention to using plasticizers or additives to make the membranes more stable and workable. During the course of these studies, other high-performance polymers (like polyamides and polyimides) were found to be better materials, which could be used either by themselves or blends with PBI. These alternative high-performance polymers provided the best pathway forward for soluble high-temperature polymers with good stable film formation properties. At present, the VTEC polyimides (product of RBI, Inc.) are the best film formers that exhibit high-temperature resistance. INL’s gas testing results show VTEC polyimides have very good gas selectivities for both H2/CO2 and CO2/CH4. Overall, these high-performance polymers pointed towards new research areas where INL has gained a greater understanding of polymer film formation and gas separation. These studies are making possible a direct approach to stable polymer-based high-temperature gas separation membranes. This report is separated into several sections due to the complexity of the research and the variation with the development of better high-temperature, gas separation membranes. Several fiscal years are combined because the research and development efforts within those areas crossed fiscal year boundaries.« less

  8. Prevalence, populations and pheno- and genotypic characteristics of Listeria monocytogenes isolated from ready-to-eat vegetables marketed in São Paulo, Brazil.

    PubMed

    Sant'Ana, Anderson S; Igarashi, Maria Crystina; Landgraf, Mariza; Destro, Maria Teresa; Franco, Bernadette D G M

    2012-04-02

    Listeria monocytogenes is a foodborne pathogen of great concern due to the high fatality rates of listeriosis. The consumption of RTE vegetables has increased in Brazil over the last two decades, but little is known about the risks associated to the consumption of these products. This study evaluated the prevalence and counts of L. monocytogenes in 512 packages of ready-to-eat vegetables marketed in São Paulo. The isolates were characterized for their serotypes, ribotypes, positivity for virulence genes inlA, inlC and inlJ, resistance to chlorine, growth rate variability and capability to form biofilm on stainless steel (AISI 304, #4) coupons. L. monocytogenes was detected in 3.1% of the samples. Only five samples presented countable levels, with counts between 1.0×10(1) and 2.6×10(2)CFU/g. Isolates belonged to serotypes 1/2b or 4b and most were positive for genes inlC and inlJ. Ribotypable isolates were grouped into four groups: 1038 (69.4%), 19175 (11.3%), 19191 (17.7%) and 18604 (one isolate). Most isolates survived to exposure to 125 ppm of a chlorine-based disinfectant for 3 min. All isolates were capable to attach to the coupons, reaching counts above 4 log(10) CFU/cm(2) and the growth rate (μ) at 25°C of the majority of the isolates varied between 0.1 and 0.2 log OD/h, but for few strains the μ was as high as 0.26 log OD/h. Results of this survey indicate that RTE vegetables may be vehicles of L. monocytogenes strains with limited variation in serotype, ribotype and virulence factors but varying significantly in resistance to chlorine disinfectants, capability of forming biofilm and growth rate. Data obtained is of foremost importance to serve as baseline for the development of scientific-based policies to control the incidence of L. monocytogenes in RTE vegetables in Brazil. Copyright © 2012 Elsevier B.V. All rights reserved.

  9. AGR-3/4 Final Data Qualification Report for ATR Cycles 151A through 155B-1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pham, Binh T.

    2015-03-01

    This report provides the qualification status of experimental data for the entire Advanced Gas Reactor 3/4 (AGR 3/4) fuel irradiation. AGR-3/4 is the third in a series of planned irradiation experiments conducted in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) for the AGR Fuel Development and Qualification Program, which supports development of the advanced reactor technology under the INL ART Technology Development Office (TDO). The main objective of AGR-3/4 irradiation is to provide a known source of fission products for subsequent transport through compact matrix and structural graphite materials due to the presence of designed-to-fail fuel particles.more » Full power irradiation of the AGR 3/4 test began on December 14, 2011 (ATR Cycle 151A), and was completed on April 12, 2014 (end of ATR Cycle 155B) after 369.1 effective full power days of irradiation. The AGR-3/4 test was in the reactor core for eight of the ten ATR cycles between 151A and 155B. During the unplanned outage cycle, 153A, the experiment was removed from the ATR northeast flux trap (NEFT) location and stored in the ATR canal. This was to prevent overheating of fuel compacts due to higher than normal ATR power during the subsequent Powered Axial Locator Mechanism cycle, 153B. The AGR 3/4 test was inserted back into the ATR NEFT location during the outage of ATR Cycle 154A on April 26, 2013. Therefore, the AGR-3/4 irradiation data received during these 2 cycles (153A and 153B) are irrelevant and their qualification status isnot included in this report. Additionally, during ATR Cycle 152A the ATR core ran at low power for a short enough duration that the irradiation data are not used for physics and thermal calculations. However, the qualification status of irradiation data for this cycle is still covered in this report. As a result, this report includes data from 8 ATR Cycles: 151A, 151B, 152A, 152B, 154A, 154B, 155A, and 155B, as recorded in the Nuclear Data Management and Analysis System (NDMAS). The AGR 3/4 data streams addressed in this report include thermocouple (TC) temperatures, sweep gas data (flow rates, pressure, and moisture content), and Fission Product Monitoring System (FPMS) data (release rates, release to birth rate ratios [R/Bs], and particle failure counts) for each of the twelve capsules in the AGR 3/4 experiment. During Outage Cycle 155A, fourteen flow meters were installed downstream from fourteen FPMS monitors to measure flows from the monitors; qualification status of these data are also included in the report. The final data qualification status for these data streams is determined by a Data Review Committee (DRC) composed of AGR technical leads, Sitewide Quality Assurance (QA), and NDMAS analysts. For ATR Cycles 151A through 154B, the DRC convened on February 12, 2014, reviewed the data acquisition process, and considered whether the data met the requirements for data collection as specified in QA approved INL ART TDO data collection plans. The DRC also examined the results of NDMAS data testing and statistical analyses, and confirmed the qualification status of the data as given in this report. The qualification status of AGR-3/4 irradiation data during the first six cycles were previously reported in INL/EXT-14-31186 document. This report presents data qualification status for the entire AGR-3/4 irradiation.« less

  10. Epithelial Keratins Modulate cMet Expression and Signaling and Promote InlB-Mediated Listeria monocytogenes Infection of HeLa Cells.

    PubMed

    Cruz, Rui; Pereira-Castro, Isabel; Almeida, Maria T; Moreira, Alexandra; Cabanes, Didier; Sousa, Sandra

    2018-01-01

    The host cytoskeleton is a major target for bacterial pathogens during infection. In particular, pathogens usurp the actin cytoskeleton function to strongly adhere to the host cell surface, to induce plasma membrane remodeling allowing invasion and to spread from cell to cell and disseminate to the whole organism. Keratins are cytoskeletal proteins that are the major components of intermediate filaments in epithelial cells however, their role in bacterial infection has been disregarded. Here we investigate the role of the major epithelial keratins, keratins 8 and 18 (K8 and K18), in the cellular infection by Listeria monocytogenes . We found that K8 and K18 are required for successful InlB/cMet-dependent L. monocytogenes infection, but are dispensable for InlA/E-cadherin-mediated invasion. Both K8 and K18 accumulate at InlB-mediated internalization sites following actin recruitment and modulate actin dynamics at those sites. We also reveal the key role of K8 and K18 in HGF-induced signaling which occurs downstream the activation of cMet. Strikingly, we show here that K18, and at a less extent K8, controls the expression of cMet and other surface receptors such TfR and integrin β1, by promoting the stability of their corresponding transcripts. Together, our results reveal novel functions for major epithelial keratins in the modulation of actin dynamics at the bacterial entry sites and in the control of surface receptors mRNA stability and expression.

  11. Prevalence, genetic diversity and antimicrobial resistance of Listeria monocytogenes isolated from fresh and smoked fish in Poland.

    PubMed

    Wieczorek, Kinga; Osek, Jacek

    2017-06-01

    A total of 57 out of 301 (18.9%) fresh and smoked fish samples in Poland were positive for Listeria monocytotgenes. The bacteria were most frequently identified in fresh and smoked salmon (32.0% and 33.8% respectively) as well as in fresh cod (31.8%). Only three samples of smoked salmon were contaminated with the bacteria above 100 CFU/g. Four molecular serogroups were identified and the most prevalent, 1/2a-3a (40 isolates; 70.2%), was present in samples from both marine (33 strains; 71.7%) and freshwater fish (7 isolates; 63.6%). Similar duality of prevalence was observed only for L. monocytogenes of 1/2b-3b-7 serogroup (14 strains; 24.6%), which was identified in 11 (23.9%) marine and 3 (27.3%) freshwater fish. All isolates harboured 10 virulence-associated genes (inlA, inlB, inlC, inlJ, lmo2672, plcA, plcB, hlyA, actA, and mpl) and most of them (56; 98.2%) also possessed the flaA marker. Several strains displayed resistance to oxacillin (33; 57.9%), ceftriaxone (18; 31.6%), or clindamycin (5; 8.8%), and two isolates of serogroup 1/2a-3a showed multiresistance to all three. Genetic subtyping showed the presence of different pulsotypes belonging to six PFGE clusters. The obtained results provide useful information regarding fish contamination with L. monocytogenes which may have implications for public health. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Joint tests at INL and CEA of a transient hot wire needle probe for in-pile thermal conductivity measurement

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daw, J.E.; Knudson, D.L.; Villard, J.F.

    2015-07-01

    Thermal conductivity is a key property that must be known for proper design, testing, and deployment of new fuels and structural materials in nuclear reactors. Thermal conductivity is highly dependent on the physical structure, chemical composition, and the state of the material. Typically, thermal conductivity changes that occur during irradiation are currently measured out-of-pile using a 'cook and look' approach. But repeatedly removing samples from a test reactor to make measurements is expensive, has the potential to disturb phenomena of interest, and only provides understanding of the sample's end state when each measurement is made. There are also limited thermo-physicalmore » property data available for advanced fuels; and such data are needed for simulation codes, the development of next generation reactors, and advanced fuels for existing nuclear plants. Being able to quickly characterize fuel thermal conductivity during irradiation can improve the fidelity of data, reduce costs of post-irradiation examinations, increase understanding of how fuels behave under irradiation, and confirm or improve existing thermal conductivity measurement techniques. This paper discusses efforts to develop and evaluate an innovative in-pile thermal conductivity sensor based on the transient hot wire thermal conductivity method (THWM), using a single needle probe (NP) containing a line heat source and thermocouple embedded in the fuel. The sensor that has been designed and manufactured by the Idaho National Laboratory (INL) includes a unique combination of materials, geometry, and fabrication techniques that make the hot wire method suitable for in-pile applications. In particular, efforts were made to minimize the influence of the sensor and maximize fuel hot-wire heating. The probe has a thermocouple-like construction with high temperature resistant materials that remain ductile while resisting transmutation and materials interactions. THWM-NP prototypes were fabricated for both room temperature proof-of-concept evaluations and high temperature testing. Evaluations have been performed jointly by the INL and the French Alternative Energies and Atomic Energy Commission (CEA), both in Idaho Falls (USA) and in Cadarache (France), in the framework of a collaborative program for instrumentation of Material Testing Reactors. Initial tests were conducted on samples with a large range of thermal conductivities and temperatures ranging from 20 deg. C to 600 deg. C. Particularly, tests were recently performed on a sample having thermal conductivity and dimensions similar to UO{sub 2} and MOX nuclear fuels, in order to validate the ability of this sensor to operate for in-pile characterization of Light Water Reactors fuels. The results of the tests already completed at INL and CEA indicate that the Transient Hot Wire Needle Probe offers an enhanced method for in-pile detection of thermal conductivity. (authors)« less

  13. Cultural Resource Investigations for the Resumption of Transient Testing of Nuclear Fuels and Material at the Idaho National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pace, Brenda R.; Williams, Julie B.

    2013-11-01

    The U. S. Department of Energy (DOE) has a need to test nuclear fuels under conditions that subject them to short bursts of intense, high-power radiation called ‘transient testing’ in order to gain important information necessary for licensing new nuclear fuels for use in U.S. nuclear power plants, for developing information to help improve current nuclear power plant performance and sustainability, for improving the affordability of new generation reactors, for developing recyclable nuclear fuels, and for developing fuels that inhibit any repurposing into nuclear weapons. To meet this mission need, DOE is considering alternatives for re-use and modification of existingmore » nuclear reactor facilities to support a renewed transient testing program. One alternative under consideration involves restarting the Transient Reactor Test (TREAT) reactor located at the Materials and Fuels Complex (MFC) on the Idaho National Laboratory (INL) site in southeastern Idaho. This report summarizes cultural resource investigations conducted by the INL Cultural Resource Management Office in 2013 to support environmental review of activities associated with restarting the TREAT reactor at the INL. These investigations were completed in order to identify and assess the significance of cultural resources within areas of potential effect associated with the proposed action and determine if the TREAT alternative would affect significant cultural resources or historic properties that are eligible for nomination to the National Register of Historic Places. No archaeological resources were identified in the direct area of potential effects for the project, but four of the buildings proposed for modifications are evaluated as historic properties, potentially eligible for nomination to the National Register of Historic Places. This includes the TREAT reactor (building #), control building (building #), guardhouse (building #), and warehouse (building #). The proposed re-use of these historic properties is consistent with original missions related to nuclear reactor testing and is expected to result in no adverse effects to their historic significance. Cultural resource investigations also involved communication with representatives from the Shoshone-Bannock Tribes to characterize cultural resources of potential tribal concern. This report provides a summary of the cultural resources inventoried and assessed within the defined areas of potential effect for the resumption of transient testing at the INL. Based on these analyses, proposed activities would have no adverse effects on historic properties within the APEs that have been defined. Other archaeological resources and cultural resources of potential concern to the Shoshone-Bannock Tribes and others that are located near the APEs are also discussed with regard to potential indirect impacts. The report concludes with general recommendations for measures to reduce impacts to all identified resources.« less

  14. 137Cs activities and 135Cs/137Cs isotopic ratios from soils at Idaho National Laboratory: a case study for contaminant source attribution in the vicinity of nuclear facilities.

    PubMed

    Snow, Mathew S; Snyder, Darin C; Clark, Sue B; Kelley, Morgan; Delmore, James E

    2015-03-03

    Radiometric and mass spectrometric analyses of Cs contamination in the environment can reveal the location of Cs emission sources, release mechanisms, modes of transport, prediction of future contamination migration, and attribution of contamination to specific generator(s) and/or process(es). The Subsurface Disposal Area (SDA) at Idaho National Laboratory (INL) represents a complicated case study for demonstrating the current capabilities and limitations to environmental Cs analyses. (137)Cs distribution patterns, (135)Cs/(137)Cs isotope ratios, known Cs chemistry at this site, and historical records enable narrowing the list of possible emission sources and release events to a single source and event, with the SDA identified as the emission source and flood transport of material from within Pit 9 and Trench 48 as the primary release event. These data combined allow refining the possible number of waste generators from dozens to a single generator, with INL on-site research and reactor programs identified as the most likely waste generator. A discussion on the ultimate limitations to the information that (135)Cs/(137)Cs ratios alone can provide is presented and includes (1) uncertainties in the exact date of the fission event and (2) possibility of mixing between different Cs source terms (including nuclear weapons fallout and a source of interest).

  15. 137 Cs Activities and 135 Cs/ 137 Cs Isotopic Ratios from Soils at Idaho National Laboratory: A Case Study for Contaminant Source Attribution in the Vicinity of Nuclear Facilities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Snow, Mathew S.; Snyder, Darin C.; Clark, Sue B.

    2015-03-03

    Radiometric and mass spectrometric analyses of Cs contamination in the environment can reveal the location of Cs emission sources, release mechanisms, modes of transport, prediction of future contamination migration, and attribution of contamination to specific generator(s) and/or process(es). The Subsurface Disposal Area (SDA) at Idaho National Laboratory (INL) represents a complicated case study for demonstrating the current capabilities and limitations to environmental Cs analyses. 137Cs distribution patterns, 135Cs/ 137Cs isotope ratios, known Cs chemistry at this site, and historical records enable narrowing the list of possible emission sources and release events to a single source and event, with the SDAmore » identified as the emission source and flood transport of material from within Pit 9 and Trench 48 as the primary release event. These data combined allow refining the possible number of waste generators from dozens to a single generator, with INL on-site research and reactor programs identified as the most likely waste generator. A discussion on the ultimate limitations to the information that 135Cs/ 137Cs ratios alone can provide is presented and includes (1) uncertainties in the exact date of the fission event and (2) possibility of mixing between different Cs source terms (including nuclear weapons fallout and a source of interest).« less

  16. Indium-loaded Liquid Scintillator for the Low Energy Neutrino Spectrometer (LENS)

    NASA Astrophysics Data System (ADS)

    Hu, Liangming; Hans, Sunej; Rosero, Richard; Beriguete, Wanda; Chan, Wai Ting; Cumming, James; Yeh, Minfang; Roundtree, Derek; Vogelaar, Bruce

    2012-03-01

    The Chemistry Department at Brookhaven National Laboratory has a long history of neutrino research since Ray Davis's Homestake experiment. The Solar Neutrino and Nuclear Chemistry group has been successfully building large neutrino detectors over the past decade for various physics experiments, using tens to hundreds of tons of liquid scintillator. Among them, LENS aims to use 8% indium-loaded LS (In-LS, first investigated by Raghavan in the 1970s) for a real-time measurement of over 95% of sub-MeV solar neutrinos, mainly from pp-, CNO-, and ^7Be-processes. A nearly background-free spectral image from neutrino interactions on ^115In can be obtained via a triple coincidence tag in space and time. LENS detector R&D has made major progress in the recent years. The development of In-LS, in collaboration with Virginia Tech, now meets the challenging requirements of light yield, optical clarity, and chemical stability; and the collaboration is in the process of building a 410-L prototype (miniLENS). In this talk, the preparation and properties of In-LS for the miniLENS detector will be presented.

  17. Final Report - Assessment of Testing Options for the NTR at the INL

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Howe, Steven D; McLing, Travis L; McCurry, Michael

    One of the main technologies that can be developed to dramatically enhance the human exploration of space is the nuclear thermal rocket (NTR). Several studies over the past thirty years have shown that the NTR can reduce the cost of a lunar outpost, reduce the risk of a human mission to Mars, enable fast transits for most missions throughout the solar system, and reduce the cost and time for robotic probes to deep space. Three separate committees of the National Research Council of the National Academy of Sciences have recommended that NASA develop the NTR. One of the primary issuesmore » in development of the NTR is the ability to verify a flight ready unit. Three main methods can be used to validate safe operation of a NTR: 1) Full power, full duration test in an above ground facility that scrubs the rocket exhaust clean of any fission products; 2) Full power , full duration test using the Subsurface Active Filtering of Exhaust (SAFE) technique to capture the exhaust in subsurface strata; 3) Test of the reactor fuel at temperature and power density in a driver reactor with subsequent first test of the fully integrated NTR in space. The first method, the above ground facility, has been studied in the past. The second method, SAFE, has been examined for application at the Nevada Test Site. The third method relies on the fact that the Nuclear Furnace series of tests in 1971 showed that the radioactive exhaust coming from graphite based fuel for the NTR could be completely scrubbed of fission products and the clean hydrogen flared into the atmosphere. Under funding from the MSFC, the Center for Space Nuclear Research (CSNR) at the Idaho National laboratory (INL) has completed a reexamination of Methods 2 and 3 for implementation at the INL site. In short, the effort performed the following: 1) Assess the geology of the INL site and determine a location suitable SAFE testing; 2) Perform calculations of gas transport throughout the geology; 3) Produce a cost estimate of a non-nuclear , sub-scale test using gas injection to validate the computational models; 4) Produce a preliminary cost estimate to build a nuclear furnace equivalent facility to test NTR fuel on a green field location on the INL site. The results show that the INL geology is substantially better suited to the SAFE testing method than the NTS site. The existence of impermeable interbeds just above the sub-surface aquifer ensure that no material from the test, radioactive or not, can enter the water table. Similar beds located just below the surface will prevent any gaseous products from reaching the surface for dispersion. The extremely high permeability of the strata between the interbeds allows rapid dispersion of the rocket exhaust. In addition, the high permeability suggests that a lower back-pressure may develop in the hole against the rocket thrust, which increases safety of operations. Finally, the cost of performing a sub-scale, non-nuclear verification experiment was determined to be $3M. The third method was assessed through discussions with INL staff resident at the site. In essence, any new Category I facility on any DOE site will cost in excess of $250M. Based on the results of this study, a cost estimate for testing a nuclear rocket at the INL site appears to be warranted. Given the fact that a new nuclear fuel may be possible that does not release any fission products, the SAFE testing option appears to be the most affordable.« less

  18. An update of hydrologic conditions and distribution of selected constituents in water, Snake River Plain aquifer and perched groundwater zones, Idaho National Laboratory, Idaho, emphasis 2006-08

    USGS Publications Warehouse

    Davis, Linda C.

    2010-01-01

    Since 1952, radiochemical and chemical wastewater discharged to infiltration ponds (also called percolation ponds), evaporation ponds, and disposal wells at the Idaho National Laboratory (INL) has affected water quality in the eastern Snake River Plain aquifer and perched groundwater zones underlying the INL. The U.S. Geological Survey, in cooperation with the U.S. Department of Energy, maintains groundwater monitoring networks at the INL to determine hydrologic trends, and to delineate the movement of radiochemical and chemical wastes in the aquifer and in perched groundwater zones. This report presents an analysis of water-level and water-quality data collected from aquifer and perched groundwater wells in the USGS groundwater monitoring networks during 2006-08. Water in the Snake River Plain aquifer primarily moves through fractures and interflow zones in basalt, generally flows southwestward, and eventually discharges at springs along the Snake River. The aquifer primarily is recharged from infiltration of irrigation water, infiltration of streamflow, groundwater inflow from adjoining mountain drainage basins, and infiltration of precipitation. From March-May 2005 to March-May 2008, water levels in wells generally remained constant or rose slightly in the southwestern corner of the INL. Water levels declined in the central and northern parts of the INL. The declines ranged from about 1 to 3 feet in the central part of the INL, to as much as 9 feet in the northern part of the INL. Water levels in perched groundwater wells around the Advanced Test Reactor Complex (ATRC) also declined. Detectable concentrations of radiochemical constituents in water samples from wells in the Snake River Plain aquifer at the INL generally decreased or remained constant during 2006-08. Decreases in concentrations were attributed to decreased rates of radioactive-waste disposal, radioactive decay, changes in waste-disposal methods, and dilution from recharge and underflow. In April or October 2008, reportable concentrations of tritium in groundwater ranged from 810 ? 70 to 8,570 ? 190 picocuries per liter (pCi/L), and the tritium plume extended south-southwestward in the general direction of groundwater flow. Tritium concentrations in water from wells completed in shallow perched groundwater at the ATRC were less than the reporting levels. Tritium concentrations in deep perched groundwater exceeded the reporting level in 11 wells during at least one sampling event during 2006-08 at the ATRC. Tritium concentrations from one or more zones in each well were reportable in water samples collected at various depths in six wells equipped with multi-level WestbayTM packer sampling systems. Concentrations of strontium-90 in water from 24 of 52 aquifer wells sampled during April or October 2008 exceeded the reporting level. Concentrations ranged from 2.2 ? 0.7 to 32.7 ? 1.2 pCi/L. Strontium-90 has not been detected within the eastern Snake River Plain aquifer beneath the ATRC partly because of the exclusive use of waste-disposal ponds and lined evaporation ponds rather than using the disposal well for radioactive-wastewater disposal at ATRC. At the ATRC, the strontium-90 concentration in water from one well completed in shallow perched groundwater was less than the reporting level. During at least one sampling event during 2006-08, concentrations of strontium-90 in water from nine wells completed in deep perched groundwater at the ATRC were greater than reporting levels. Concentrations ranged from 2.1?0.7 to 70.5?1.8 pCi/L. At the Idaho Nuclear Technology and Engineering Center (INTEC), the reporting level was exceeded in water from two wells completed in deep perched groundwater. During 2006-08, concentrations of cesium-137, plutonium-238, and plutonium-239, -240 (undivided), and americium-241 were less than the reporting level in water samples from all wells and all zones in wells equipped with multi-level WestbayTM packer sampling systems

  19. Idaho National Laboratory Emergency Readiness Assurance Plan - Fiscal Year 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Farmer, Carl J.

    Department of Energy Order 151.1C, Comprehensive Emergency Management System requires that each Department of Energy field element documents readiness assurance activities, addressing emergency response planning and preparedness. Battelle Energy Alliance, LLC, as prime contractor at the Idaho National Laboratory (INL), has compiled this Emergency Readiness Assurance Plan to provide this assurance to the Department of Energy Idaho Operations Office. Stated emergency capabilities at the INL are sufficient to implement emergency plans. Summary tables augment descriptive paragraphs to provide easy access to data. Additionally, the plan furnishes budgeting, personnel, and planning forecasts for the next 5 years.

  20. MTR WING, TRA604. ONE OF THE LABORATORY UNITS ALONG THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR WING, TRA-604. ONE OF THE LABORATORY UNITS ALONG THE SOUTH SIDE WALL. NOTE SINK, CABINET, TABLE, AND HOOD UNITS. DUCT ABOVE RECEIVES CONTAMINATED AIR AND SENDS IT TO FAN HOUSE AND STACK. NOTE PARTITION WALL BEHIND WORK UNITS. THE HEALTH PHYSICS LAB WAS SIMILARLY EQUIPPED. WINDOW AT LEFT EDGE OF VIEW. CARD IN LOWER RIGHT WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON ORIGINAL NEGATIVE. INL NEGATIVE NO. 4225. Unknown Photographer, 2/13/1952 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  1. FY-12 INL KR CAPTURE ACTIVITIES SUPPORTING THE OFF-GAS SIGMA TEAM

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Troy G. Garn; Mitchell R. Greenhalgh; Jack D Law

    2012-08-01

    Tasks performed this year by INL Kr capture off-gas team members can be segregated into three separate task sub-sections which include: 1) The development and testing of a new engineered form sorbent, 2) An initial NDA gamma scan effort performed on the drum containing the Legacy Kr-85 sample materials, and 3) Collaborative research efforts with PNNL involving the testing of the Ni-DOBDC MOF and an initial attempt to make powdered chalcogel material into an engineered form using our binding process. This document describes the routes to success for the three task sub-sections.

  2. Hydrogen milestone could help lower fossil fuel refining costs

    ScienceCinema

    McGraw, Jennifer

    2017-12-27

    Hydrogen researchers at the U.S. Department of Energy's Idaho National Laboratory have reached another milestone on the road to reducing carbon emissions and protecting the nation against the effects of peaking world oil production. Stephen Herring, laboratory fellow and technical director of the INL High Temperature Electrolysis team, today announced that the latest fuel cell modification has set a new mark in endurance. The group's Integrated Laboratory Scale experiment has now operated continuously for 2,583 hours at higher efficiencies than previously attained. Learn more about INL research at http://www.facebook.com/idahonationallaboratory.

  3. INL Control System Situational Awareness Technology Annual Report 2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gordon Rueff; Bryce Wheeler; Todd Vollmer

    The overall goal of this project is to develop an interoperable set of tools to provide a comprehensive, consistent implementation of cyber security and overall situational awareness of control and sensor network implementations. The operation and interoperability of these tools will fill voids in current technological offerings and address issues that remain an impediment to the security of control systems. This report provides an FY 2012 update on the Sophia, Mesh Mapper, Intelligent Cyber Sensor, and Data Fusion projects with respect to the year-two tasks and annual reporting requirements of the INL Control System Situational Awareness Technology report (July 2010).

  4. Readiness Review of BWXT for Fabrication of AGR-5/6/7 TRISO Particles

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marshall, Douglas William; Sharp, Michelle Tracy

    2016-02-01

    INL readiness review assessment of BWXT readiness to commence fabrication of low-enriched TRISO coated fuel particles for the AGR-5/6/7 irradiation experiments. BWXT self-identified equipment issues preventing operation. INL identified two findings. The first was that disposition codes had not been assigned and documented on BWXT forms to ensure that off-specification materials could not be used in the fabrication of TRISO particles. The second was that chemical purity specifications were not reliably passed on to chemical suppliers, which resulted in the receipt of one acetylene cylinder with suspect impurity levels.

  5. Strategic need for a multi-purpose thermal hydraulic loop for support of advanced reactor technologies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    O'Brien, James E.; Sabharwall, Piyush; Yoon, Su -Jong

    2014-09-01

    This report presents a conceptual design for a new high-temperature multi fluid, multi loop test facility for the INL to support thermal hydraulic, materials, and thermal energy storage research for nuclear and nuclear-hybrid applications. In its initial configuration, the facility will include a high-temperature helium loop, a liquid salt loop, and a hot water/steam loop. The three loops will be thermally coupled through an intermediate heat exchanger (IHX) and a secondary heat exchanger (SHX). Research topics to be addressed with this facility include the characterization and performance evaluation of candidate compact heat exchangers such as printed circuit heat exchangers (PCHEs)more » at prototypical operating conditions, flow and heat transfer issues related to core thermal hydraulics in advanced helium-cooled and salt-cooled reactors, and evaluation of corrosion behavior of new cladding materials and accident-tolerant fuels for LWRs at prototypical conditions. Based on its relevance to advanced reactor systems, the new facility has been named the Advanced Reactor Technology Integral System Test (ARTIST) facility. Research performed in this facility will advance the state of the art and technology readiness level of high temperature intermediate heat exchangers (IHXs) for nuclear applications while establishing the INL as a center of excellence for the development and certification of this technology. The thermal energy storage capability will support research and demonstration activities related to process heat delivery for a variety of hybrid energy systems and grid stabilization strategies. Experimental results obtained from this research will assist in development of reliable predictive models for thermal hydraulic design and safety codes over the range of expected advanced reactor operating conditions. Proposed/existing IHX heat transfer and friction correlations and criteria will be assessed with information on materials compatibility and instrumentation needs. The experimental database will guide development of appropriate predictive methods and be available for code verification and validation (V&V) related to these systems.« less

  6. Status Report on Activities of the Systems Assessment Task Force, OECD-NEA Expert Group on Accident Tolerant Fuels for LWRs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bragg-Sitton, Shannon Michelle

    The Organization for Economic Cooperation and Development /Nuclear Energy Agency (OECD/NEA) Nuclear Science Committee approved the formation of an Expert Group on Accident Tolerant Fuel (ATF) for LWRs (EGATFL) in 2014. Chaired by Kemal Pasamehmetoglu, INL Associate Laboratory Director for Nuclear Science and Technology, the mandate for the EGATFL defines work under three task forces: (1) Systems Assessment, (2) Cladding and Core Materials, and (3) Fuel Concepts. Scope for the Systems Assessment task force (TF1) includes definition of evaluation metrics for ATF, technology readiness level definition, definition of illustrative scenarios for ATF evaluation, and identification of fuel performance and systemmore » codes applicable to ATF evaluation. The Cladding and Core Materials (TF2) and Fuel Concepts (TF3) task forces will identify gaps and needs for modeling and experimental demonstration; define key properties of interest; identify the data necessary to perform concept evaluation under normal conditions and illustrative scenarios; identify available infrastructure (internationally) to support experimental needs; and make recommendations on priorities. Where possible, considering proprietary and other export restrictions (e.g., International Traffic in Arms Regulations), the Expert Group will facilitate the sharing of data and lessons learned across the international group membership. The Systems Assessment task force is chaired by Shannon Bragg-Sitton (Idaho National Laboratory [INL], U.S.), the Cladding Task Force is chaired by Marie Moatti (Electricite de France [EdF], France), and the Fuels Task Force is chaired by a Masaki Kurata (Japan Atomic Energy Agency [JAEA], Japan). The original Expert Group mandate was established for June 2014 to June 2016. In April 2016 the Expert Group voted to extend the mandate one additional year to June 2017 in order to complete the task force deliverables; this request was subsequently approved by the Nuclear Science Committee. This report provides an update on the status Systems Assessment Task Force activities.« less

  7. Retinal Laminar Architecture in Human Retinitis Pigmentosa Caused by Rhodopsin Gene Mutations

    PubMed Central

    Aleman, Tomas S.; Cideciyan, Artur V.; Sumaroka, Alexander; Windsor, Elizabeth A. M.; Herrera, Waldo; White, D. Alan; Kaushal, Shalesh; Naidu, Anjani; Roman, Alejandro J.; Schwartz, Sharon B.; Stone, Edwin M.; Jacobson, Samuel G.

    2008-01-01

    Purpose. To determine the underlying retinal micropathology in subclasses of autosomal dominant retinitis pigmentosa (ADRP) caused by rhodopsin (RHO) mutations. Methods. Patients with RHO-ADRP (n = 17, ages 6–73 years), representing class A (R135W and P347L) and class B (P23H, T58R, and G106R) functional phenotypes, were studied with optical coherence tomography (OCT), and colocalized visual thresholds were determined by dark- and light-adapted chromatic perimetry. Autofluorescence imaging was performed with near-infrared light. Retinal histology in hT17M-rhodopsin mice was compared with the human results. Results. Class A patients had only cone-mediated vision. The outer nuclear layer (ONL) thinned with eccentricity and was not detectable within 3 to 4 mm of the fovea. Scotomatous extracentral retina showed loss of ONL, thickening of the inner retina, and demelanization of RPE. Class B patients had superior–inferior asymmetry in function and structure. The superior retina could have normal rod and cone vision, normal lamination (including ONL) and autofluorescence of the RPE melanin; laminopathy was found in the scotomas. With Fourier-domain-OCT, there was apparent inner nuclear layer (INL) thickening in regions with ONL thinning. Retinal regions without ONL had a thick hyporeflective layer that was continuous with the INL from neighboring regions with normal lamination. Transgenic mice had many of the laminar abnormalities found in patients. Conclusions. Retinal laminar abnormalities were present in both classes of RHO-ADRP and were related to the severity of colocalized vision loss. The results in human class B and the transgenic mice support the following disease sequence: ONL diminution with INL thickening; amalgamation of residual ONL with the thickened INL; and progressive retinal remodeling with eventual thinning. PMID:18385078

  8. Prevalence, antimicrobial susceptibility and virulotyping of Listeria species and Listeria monocytogenes isolated from open-air fish markets.

    PubMed

    Jamali, Hossein; Paydar, Mohammadjavad; Ismail, Salmah; Looi, Chung Yeng; Wong, Won Fen; Radmehr, Behrad; Abedini, Atefeh

    2015-07-25

    The aim of this study was to investigate the prevalence and characterization of Listeria species and Listeria monocytogenes isolated from raw fish and open-air fish market environments. Eight hundred and sixty two samples including raw fish and fish market environments (samples from workers' hands, workers' knives, containers and work surface) were collected from the open-air fish markets in the Northern region of Iran. Listeria spp. was isolated from 104/488 (21.3%) raw fish and 29/374 (7.8%) of samples from open-air fish market environment. The isolates of Listeria spp. included L. innocua (35.3%), L. monocytogenes (32.3%), L. seeligeri (18%), and L. ivanovii (14.3%). Of the 43 L. monocytogenes isolates, 31 (72.1%), 10 (23.3%) and 2 (4.7%) belonged to serovars 1/2a, 4b, and 1/2b, respectively. The inlA, inlB, inlC, inlJ, actA, hlyA, iap, plcA, and prfA virulence-associated genes were detected in almost all of the L. monocytogenes isolates. The Listeria spp. isolates showed high resistance against tetracycline (23.3%), penicillin G, and cephalothin (each 16.5%). Besides, we observed significant resistance level to tetracycline (27.9%), ampicillin (20.9%), cephalothin, penicillin G, and streptomycin (each 16.3%) in the L. monocytogenes isolates. All of the isolates were susceptible to cefotaxime, gentamicin, kanamycin, and pefloxacin. We found that tetM (25.6%), tetA (23.3%), ampC (14%), and penA (11.6%) were the most prevalent antibiotic resistance genes in the L. monocytogenes isolates. Recovery of potentially pathogenic L. monocytogenes from raw fish and environment of open-air fish market samples in this study is a convincing evidence for the zoonotic potential of listeriosis.

  9. Report for Task 8.4: Development of Control Room Layout Recommendations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McDonald, Robert

    Idaho National Laboratory (INL) has contracted Institutt for Energiteknikk (IFE) to support in the development of an end state vision for the US Nuclear industry and in particular for a utility that is currently moving forward with a control room modernization project. This support includes the development of an Overview display and technical support in conducting an operational study. Development of operational scenarios to be conducted using a full scope simulator at the INL HSSL. Additionally IFE will use the CREATE modelling tool to provide 3-D views of the potential and possible end state view after the completion of digitalmore » upgrade project.« less

  10. Two-photon excited autofluorescence imaging of freshly isolated frog retinas.

    PubMed

    Lu, Rong-Wen; Li, Yi-Chao; Ye, Tong; Strang, Christianne; Keyser, Kent; Curcio, Christine A; Yao, Xin-Cheng

    2011-06-01

    The purpose of this study was to investigate cellular sources of autofluorescence signals in freshly isolated frog (Rana pipiens) retinas. Equipped with an ultrafast laser, a laser scanning two-photon excitation fluorescence microscope was employed for sub-cellular resolution examination of both sliced and flat-mounted retinas. Two-photon imaging of retinal slices revealed autofluorescence signals over multiple functional layers, including the photoreceptor layer (PRL), outer nuclear layer (ONL), outer plexiform layer (OPL), inner nuclear layer (INL), inner plexiform layer (IPL), and ganglion cell layer (GCL). Using flat-mounted retinas, depth-resolved imaging of individual retinal layers further confirmed multiple sources of autofluorescence signals. Cellular structures were clearly observed at the PRL, ONL, INL, and GCL. At the PRL, the autofluorescence was dominantly recorded from the intracellular compartment of the photoreceptors; while mixed intracellular and extracellular autofluorescence signals were observed at the ONL, INL, and GCL. High resolution autofluorescence imaging clearly revealed mosaic organization of rod and cone photoreceptors; and sub-cellular bright autofluorescence spots, which might relate to connecting cilium, was observed in the cone photoreceptors only. Moreover, single-cone and double-cone outer segments could be directly differentiated.

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Clarke, Kester Diederik

    The intent of this report is to document a procedure used at LANL for HIP bonding aluminum cladding to U-10Mo fuel foils using a formed HIP can for the Domestic Reactor Conversion program in the NNSA Office of Material, Management and Minimization, and provide some details that may not have been published elsewhere. The HIP process is based on the procedures that have been used to develop the formed HIP can process, including the baseline process developed at Idaho National Laboratory (INL). The HIP bonding cladding process development is summarized in the listed references. Further iterations with Babcock & Wilcoxmore » (B&W) to refine the process to meet production and facility requirements is expected.« less

  12. Idaho National Laboratory Integrated Safety Management System FY 2013 Effectiveness Review and Declaration Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunt, Farren

    2013-12-01

    Idaho National Laboratory (INL) performed an Annual Effectiveness Review of the Integrated Safety Management System (ISMS), per 48 Code of Federal Regulations (CFR) 970.5223 1, “Integration of Environment, Safety and Health into Work Planning and Execution.” The annual review assessed Integrated Safety Management (ISM) effectiveness, provided feedback to maintain system integrity, and identified target areas for focused improvements and assessments for Fiscal Year (FY) 2014. Results of the FY 2013 annual effectiveness review demonstrate that the INL’s ISMS program is “Effective” and continually improving and shows signs of being significantly strengthened. Although there have been unacceptable serious events in themore » past, there has also been significant attention, dedication, and resources focused on improvement, lessons learned and future prevention. BEA’s strategy of focusing on these improvements includes extensive action and improvement plans that include PLN 4030, “INL Sustained Operational Improvement Plan, PLN 4058, “MFC Strategic Excellence Plan,” PLN 4141, “ATR Sustained Excellence Plan,” and PLN 4145, “Radiological Control Road to Excellence,” and the development of LWP 20000, “Conduct of Research.” As a result of these action plans, coupled with other assurance activities and metrics, significant improvement in operational performance, organizational competence, management oversight and a reduction in the number of operational events is being realized. In short, the realization of the fifth core function of ISMS (feedback and continuous improvement) and the associated benefits are apparent.« less

  13. Methodology for the Incorporation of Passive Component Aging Modeling into the RAVEN/ RELAP-7 Environment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mandelli, Diego; Rabiti, Cristian; Cogliati, Joshua

    2014-11-01

    Passive system, structure and components (SSCs) will degrade over their operation life and this degradation may cause to reduction in the safety margins of a nuclear power plant. In traditional probabilistic risk assessment (PRA) using the event-tree/fault-tree methodology, passive SSC failure rates are generally based on generic plant failure data and the true state of a specific plant is not reflected realistically. To address aging effects of passive SSCs in the traditional PRA methodology [1] does consider physics based models that account for the operating conditions in the plant, however, [1] does not include effects of surveillance/inspection. This paper representsmore » an overall methodology for the incorporation of aging modeling of passive components into the RAVEN/RELAP-7 environment which provides a framework for performing dynamic PRA. Dynamic PRA allows consideration of both epistemic and aleatory uncertainties (including those associated with maintenance activities) in a consistent phenomenological and probabilistic framework and is often needed when there is complex process/hardware/software/firmware/ human interaction [2]. Dynamic PRA has gained attention recently due to difficulties in the traditional PRA modeling of aging effects of passive components using physics based models and also in the modeling of digital instrumentation and control systems. RAVEN (Reactor Analysis and Virtual control Environment) [3] is a software package under development at the Idaho National Laboratory (INL) as an online control logic driver and post-processing tool. It is coupled to the plant transient code RELAP-7 (Reactor Excursion and Leak Analysis Program) also currently under development at INL [3], as well as RELAP 5 [4]. The overall methodology aims to: • Address multiple aging mechanisms involving large number of components in a computational feasible manner where sequencing of events is conditioned on the physical conditions predicted in a simulation environment such as RELAP-7. • Identify the risk-significant passive components, their failure modes and anticipated rates of degradation • Incorporate surveillance and maintenance activities and their effects into the plant state and into component aging progress. • Asses aging affects in a dynamic simulation environment 1. C. L. SMITH, V. N. SHAH, T. KAO, G. APOSTOLAKIS, “Incorporating Ageing Effects into Probabilistic Risk Assessment –A Feasibility Study Utilizing Reliability Physics Models,” NUREG/CR-5632, USNRC, (2001). 2. T. ALDEMIR, “A Survey of Dynamic Methodologies for Probabilistic Safety Assessment of Nuclear Power Plants, Annals of Nuclear Energy, 52, 113-124, (2013). 3. C. RABITI, A. ALFONSI, J. COGLIATI, D. MANDELLI and R. KINOSHITA “Reactor Analysis and Virtual Control Environment (RAVEN) FY12 Report,” INL/EXT-12-27351, (2012). 4. D. ANDERS et.al, "RELAP-7 Level 2 Milestone Report: Demonstration of a Steady State Single Phase PWR Simulation with RELAP-7," INL/EXT-12-25924, (2012).« less

  14. Steady-State and Transient Groundwater Flow and Advective Transport, Eastern Snake River Plain Aquifer, Idaho National Laboratory and Vicinity, Idaho

    NASA Astrophysics Data System (ADS)

    Fisher, J. C.; Ackerman, D. J.; Rousseau, J. P.; Rattray, G. W.

    2009-12-01

    Three-dimensional steady-state and transient models of groundwater flow and advective transport through the fractured basalts and interbedded sediments of the Eastern Snake River Plain (ESRP) aquifer were developed by the U.S. Geological Survey in cooperation with the U.S. Department of Energy. The model domain covers an area of 1,940 square miles that includes most of the Idaho National Laboratory (INL). A 50-year history of waste disposal at the INL has resulted in measurable concentrations of waste contaminants in the aquifer. Numerical models simulated 1980 steady-state conditions and transient flow for 1980-95. In the transient model, streamflow infiltration was the major stress. The models were calibrated using the parameter-estimation program incorporated in MODFLOW-2000. The steady-state model reasonably simulated the observed water-table altitude and gradients. Simulation of transient conditions reproduced changes in the flow system resulting from episodic infiltration from the Big Lost River. Analysis of simulations shows that flow is (1) dominantly horizontal through interflow zones in basalt, vertical anisotropy resulting from contrasts in hydraulic conductivity of different types of basalt and the interbedded sediments, (2) temporally variable due to streamflow infiltration from the Big Lost River, and (3) moving downward downgradient of the INL. Particle-tracking simulations were used to evaluate how simulated groundwater flow paths and travel times differ between the steady-state and transient flow models, and how well model-derived groundwater flow directions and velocities compare to independently-derived estimates. Particle tracking also was used to simulate the growth of tritium plumes originating at two INL facilities over a 16 year period under steady-state and transient flow conditions (1953-68). The shape, dimensions, and areal extent of these plumes were compared to a map of the plumes for 1968 from tritium releases beginning in 1952. Collectively, the particle-tracking simulations indicate that groundwater flow paths and velocities, based on uncalibrated estimates of porosity, are influenced by the dynamic character of the water table and the large contrasts in the hydraulic properties of the media, primarily hydraulic conductivity. Simulation results also indicate that temporal changes in the local hydraulic gradient can account for some of the observed dispersion of contaminants in the aquifer near the major sources of contamination and perhaps the majority of the observed dispersion several miles downgradient of these facilities. The distance downgradient of the facilities where simulated particle plumes were able to reasonably reproduce the 1968 tritium plume extended only to the boundary separating sediment-rich from sediment-poor aquifer layers about 4 mi downgradient of the contaminant source. Particle plumes simulated beyond this boundary were narrow and long, and did not reasonably reproduce the shape, dimensions, or position of the leading edge of the tritium plume; however, few data were available to characterize its true areal extent and shape.

  15. Idaho National Laboratory Cultural Resource Monitoring Report for 2013

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Williams, Julie B.

    2013-10-01

    This report describes the cultural resource monitoring activities of the Idaho National Laboratory’s (INL) Cultural Resource Management (CRM) Office during 2013. Throughout the year, thirty-eight cultural resource localities were revisited including: two locations with Native American human remains, one of which is also a cave; fourteen additional caves; seven prehistoric archaeological sites ; four historic archaeological sites; one historic trail; one nuclear resource (Experimental Breeder Reactor-I, a designated National Historic Landmark); and nine historic structures located at the Central Facilities Area. Of the monitored resources, thirty-three were routinely monitored, and five were monitored to assess project compliance with cultural resourcemore » recommendations along with the effects of ongoing project activities. On six occasions, ground disturbing activities within the boundaries of the Power Burst Facility/Critical Infrastructure Test Range Complex (PBF/CITRC) were observed by INL CRM staff prepared to respond to any additional finds of Native American human remains. In addition, two resources were visited more than once as part of the routine monitoring schedule or to monitor for additional damage. Throughout the year, most of the cultural resources monitored had no visual adverse changes resulting in Type 1determinations. However, Type 2 impacts were noted at eight sites, indicating that although impacts were noted or that a project was operating outside of culturally cleared limitations, cultural resources retained integrity and noted impacts did not threaten National Register eligibility. No new Type 3 or any Type 4 impacts that adversely impacted cultural resources and threatened National Register eligibility were observed at cultural resources monitored in 2013.« less

  16. Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection

    PubMed Central

    Eitson, Jennifer L.; Chen, Didi; Jimenez, Alyssa; Mettlen, Marcel; Schoggins, John W.; Alto, Neal M.

    2016-01-01

    The type I interferon (IFN) activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes (Lm) as a model bacterial pathogen, we sought to identify the roles of individual interferon-stimulated genes (ISGs) in context of bacterial infection. Previously, IFN has been implicated in both restricting and promoting Lm growth and immune stimulatory functions in vivo. Here we adapted a gain-of-function flow cytometry based approach to screen a library of more than 350 human ISGs for inhibitors and enhancers of Lm infection. We identify 6 genes, including UNC93B1, MYD88, AQP9, and TRIM14 that potently inhibit Lm infection. These inhibitors act through both transcription-mediated (MYD88) and non-transcriptional mechanisms (TRIM14). Further, we identify and characterize the human high affinity immunoglobulin receptor FcγRIa as an enhancer of Lm internalization. Our results reveal that FcγRIa promotes Lm uptake in the absence of known host Lm internalization receptors (E-cadherin and c-Met) as well as bacterial surface internalins (InlA and InlB). Additionally, FcγRIa-mediated uptake occurs independently of Lm opsonization or canonical FcγRIa signaling. Finally, we established the contribution of FcγRIa to Lm infection in phagocytic cells, thus potentially linking the IFN response to a novel bacterial uptake pathway. Together, these studies provide an experimental and conceptual basis for deciphering the role of IFN in bacterial defense and virulence at single-gene resolution. PMID:28002492

  17. Advanced Instrumentation, Information, and Control Systems Technologies Pathway: FY 2016 External Review

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thomas, Kenneth David; Hallbert, Bruce Perry

    2016-11-01

    This report describes an External Review conducted by the LWRS Program Advanced Instrumentation, Information, and Control (II&C) Systems Technologies Pathway to solicit feedback on the topics and results of the ongoing II&C research program. This review was held in conjunction with the Nuclear Energy Institute (NEI) Digital I&C Working Group meeting that was held at Idaho National Laboratory (INL) on August 9-10, 2016. Given the opportunity to visit INL and see the pathway research projects, NEI agreed that the Working Group would serve as the External Review panel for the purpose of obtaining expert input on the value and timingmore » of the research projects. This consisted of demonstrations in the Human Systems Simulation Laboratory followed by presentations on the II&C research program in general as well as the five technology development areas. Following the meeting, the presentations were sent to each of the attendees so they could review them in more detail and refer to them in completing the feedback form. Follow-up activities were conducted with the attendees following the meeting to obtain the completed feedback forms. A total of 13 forms were returned. The feedback forms were reviewed by the pathway to compile the data and comments received, which are documented in the report. In all, the feedback provided by the External Review participants is taken to be a strong endorsement of the types of projects being conducted by the pathway, the value they hold for the nuclear plants, and the general timing of need. The feedback aligns well with the priorities, levels of efforts allocated for the research projects, and project schedules. The feedback also represents realistic observations on the practicality of some aspects of implementing these technologies. In some cases, the participants provided thoughtful challenges to certain assumptions in the formulation of the technologies or in deployment plans. These deserve further review and revision of plans if warranted. The pathway will take all of the feedback and address the open issues that have been identified by the participants. This includes 11 actionable items for follow up by the II&C Pathway.« less

  18. Numerical Simulation of Metallic Uranium Sintering

    NASA Astrophysics Data System (ADS)

    Berry, Bruce

    Conventional ceramic oxide nuclear fuels are limited in their thermal and life-cycle properties. The desire to operate at higher burnups as is required by current utility economics has proven a formidable challenge for oxide fuel designs. Metallic formulations have superior thermal performance but are plagued by volumetric swelling due to fission gas buildup. In this study, we consider a number of specific microstructure configurations that have been experimentally shown to exhibit considerable resistance to porosity loss. Specifically, a void sizing that is bimodally distributed was shown to resist early pore loss and could provide collection sites for fission gas buildup. We employ the phase field model of Cahn and Hilliard, solved via the finite element method using the open source Multi-User Object Oriented Simulation Environment (MOOSE) developed by INL.

  19. Updated procedures for using drill cores and cuttings at the Lithologic Core Storage Library, Idaho National Laboratory, Idaho

    USGS Publications Warehouse

    Hodges, Mary K.V.; Davis, Linda C.; Bartholomay, Roy C.

    2018-01-30

    In 1990, the U.S. Geological Survey, in cooperation with the U.S. Department of Energy Idaho Operations Office, established the Lithologic Core Storage Library at the Idaho National Laboratory (INL). The facility was established to consolidate, catalog, and permanently store nonradioactive drill cores and cuttings from subsurface investigations conducted at the INL, and to provide a location for researchers to examine, sample, and test these materials.The facility is open by appointment to researchers for examination, sampling, and testing of cores and cuttings. This report describes the facility and cores and cuttings stored at the facility. Descriptions of cores and cuttings include the corehole names, corehole locations, and depth intervals available.Most cores and cuttings stored at the facility were drilled at or near the INL, on the eastern Snake River Plain; however, two cores drilled on the western Snake River Plain are stored for comparative studies. Basalt, rhyolite, sedimentary interbeds, and surficial sediments compose most cores and cuttings, most of which are continuous from land surface to their total depth. The deepest continuously drilled core stored at the facility was drilled to 5,000 feet below land surface. This report describes procedures and researchers' responsibilities for access to the facility and for examination, sampling, and return of materials.

  20. Listeria Species in Broiler Poultry Farms: Potential Public Health Hazards.

    PubMed

    Dahshan, Hesham; Merwad, Abdallah Mohamed Amin; Mohamed, Taisir Saber

    2016-09-28

    Broiler meat production worldwide has been plagued by lethal food-poisoning bacteria diseases, including listeriosis. A fatality rate of 15.6% was recorded in human beings in the EU in 2015. During 2013, a total of 200 poultry farm samples, including litter, chicken breast, farm feed, and drinking water, were collected to generate baseline data for the characterization of the genus Listeria in broiler poultry farms. Listeria spp. were detected in a total of 95 (47.5%) poultry farm samples. The isolates of Listeria spp. included L. innocua (28.5%), L. ivanovii (12.5%), L. welshimeri (4.5%), and L. monocytogenes and L. seeligeri (1% each). Listeria spp. contamination rates were higher in farm feed (70%), followed by litter (52.5%), chicken breasts (42.2%), and drinking water (10%). Almost all Listeria spp. isolates were resistant to more than three classes of antibiotics (multidrug resistant). Besides this, we observed a significant resistance level to penicillin and fluoroquinolone drugs. However, lower resistance levels were recorded for broad-spectrum cephalosporins. The inlA, inlC, and inlJ virulence genes were detected in almost all of the L. monocytogenes isolates. Thus, food safety management approaches and interventions at all stages of the broiler rearing cycle were needed to control cross-contamination and the zoonotic potential of listeriosis.

  1. Versatile Stimulation Back-End With Programmable Exponential Current Pulse Shapes for a Retinal Visual Prosthesis.

    PubMed

    Maghami, Mohammad Hossein; Sodagar, Amir M; Sawan, Mohamad

    2016-11-01

    This paper reports on the design, implementation, and test of a stimulation back-end, for an implantable retinal prosthesis. In addition to traditional rectangular pulse shapes, the circuit features biphasic stimulation pulses with both rising and falling exponential shapes, whose time constants are digitally programmable. A class-B second generation current conveyor is used as a wide-swing, high-output-resistance stimulation current driver, delivering stimulation current pulses of up to ±96 μA to the target tissue. Duration of the generated current pulses is programmable within the range of 100 μs to 3 ms. Current-mode digital-to-analog converters (DACs) are used to program the amplitudes of the stimulation pulses. Fabricated using the IBM 130 nm process, the circuit consumes 1.5×1.5 mm 2 of silicon area. According to the measurements, the DACs exhibit DNL and INL of 0.23 LSB and 0.364 LSB, respectively. Experimental results indicate that the stimuli generator meets expected requirements when connected to electrode-tissue impedance of as high as 25 k Ω. Maximum power consumption of the proposed design is 3.4 mW when delivering biphasic rectangular pulses to the target load. A charge pump block is in charge of the upconversion of the standard 1.2-V supply voltage to ±3.3V.

  2. Recent Upgrades at the Safety and Tritium Applied Research Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cadwallader, Lee Charles; Merrill, Brad Johnson; Stewart, Dean Andrew

    This paper gives a brief overview of the Safety and Tritium Applied Research (STAR) facility operated by the Fusion Safety Program (FSP) at the Idaho National Laboratory (INL). FSP researchers use the STAR facility to carry out experiments in tritium permeation and retention in various fusion materials, including wall armor tile materials. FSP researchers also perform other experimentation as well to support safety assessment in fusion development. This lab, in its present two-building configuration, has been in operation for over ten years. The main experiments at STAR are briefly described. This paper discusses recent work to enhance personnel safety atmore » the facility. The STAR facility is a Department of Energy less than hazard category 3 facility; the personnel safety approach calls for ventilation and tritium monitoring for radiation protection. The tritium areas of STAR have about 4 to 12 air changes per hour, with air flow being once through and then routed to the facility vent stack. Additional radiation monitoring has been installed to read the laboratory room air where experiments with tritium are conducted. These ion chambers and bubblers are used to verify that no significant tritium concentrations are present in the experiment rooms. Standby electrical power has been added to the facility exhaust blower so that proper ventilation will now operate during commercial power outages as well as the real-time tritium air monitors.« less

  3. Hydraulic Shuttle Irradiation System (HSIS) Recently Installed in the Advanced Test Reactor (ATR)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    A. Joseph Palmer; Gerry L. McCormick; Shannon J. Corrigan

    2010-06-01

    2010 International Congress on Advances in Nuclear Power Plants (ICAPP’10) ANS Annual Meeting Imbedded Topical San Diego, CA June 13 – 17, 2010 Hydraulic Shuttle Irradiation System (HSIS) Recently Installed in the Advanced Test Reactor (ATR) Author: A. Joseph Palmer, Mechanical Engineer, Irradiation Test Programs, 208-526-8700, Joe.Palmer@INL.gov Affiliation: Idaho National Laboratory P.O. Box 1625, MS-3840 Idaho Falls, ID 83415 INL/CON-10-17680 ABSTRACT Most test reactors are equipped with shuttle facilities (sometimes called rabbit tubes) whereby small capsules can be inserted into the reactor and retrieved during power operations. With the installation of Hydraulic Shuttle Irradiation System (HSIS) this capability has beenmore » restored to the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL). The general design and operating principles of this system were patterned after the hydraulic rabbit at Oak Ridge National Laboratory’s (ORNL) High Flux Isotope Reactor (HFIR), which has operated successfully for many years. Using primary coolant as the motive medium the HSIS system is designed to simultaneously transport fourteen shuttle capsules, each 16 mm OD x 57 mm long, to and from the B-7 position of the reactor. The B-7 position is one of the higher flux positions in the reactor with typical thermal and fast (>1 Mev) fluxes of 2.8E+14 n/cm2/sec and 1.9E+14 n/cm2/sec respectively. The available space inside each shuttle is approximately 14 mm diameter x 50 mm long. The shuttle containers are made from titanium which was selected for its low neutron activation properties and durability. Shuttles can be irradiated for time periods ranging from a few minutes to several months. The Send and Receive Station (SRS) for the HSIS is located 2.5 m deep in the ATR canal which allows irradiated shuttles to be easily moved from the SRS to a wet loaded cask, or transport pig. The HSIS system first irradiated (empty) shuttles in September 2009 and has since completed a Readiness Assessment in November 2009. The HSIS is a key component of the ATR National Scientific User Facility (NSUF) operated by Battelle Energy Alliance, LLC and is available to a wide variety of university researchers for nuclear fuels and materials experiments as well as medical isotope research and production.« less

  4. Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Soelberg, Renae

    2014-11-01

    Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014 Highlights Rory Kennedy and Sarah Robertson attended the American Nuclear Society Winter Meeting and Nuclear Technology Expo in Anaheim, California, Nov. 10-13. ATR NSUF exhibited at the technology expo where hundreds of meeting participants had an opportunity to learn more about ATR NSUF. Dr. Kennedy briefed the Nuclear Engineering Department Heads Organization (NEDHO) on the workings of the ATR NSUF. • Rory Kennedy, James Cole and Dan Ogden participated in a reactor instrumentation discussion with Jean-Francois Villard and Christopher Destouches of CEA and several members of themore » INL staff. • ATR NSUF received approval from the NE-20 office to start planning the annual Users Meeting. The meeting will be held at INL, June 22-25. • Mike Worley, director of the Office of Innovative Nuclear Research (NE-42), visited INL Nov. 4-5. Milestones Completed • Recommendations for the Summer Rapid Turnaround Experiment awards were submitted to DOE-HQ Nov. 12 (Level 2 milestone due Nov. 30). Major Accomplishments/Activities • The University of California, Santa Barbara 2 experiment was unloaded from the GE-2000 at HFEF. The experiment specimen packs will be removed and shipped to ORNL for PIE. • The Terrani experiment, one of three FY 2014 new awards, was completed utilizing the Advanced Photon Source MRCAT beamline. The experiment investigated the chemical state of Ag and Pd in SiC shell of irradiated TRISO particles via X-ray Absorption Fine Structure (XAFS) spectroscopy. Upcoming Meetings/Events • The ATR NSUF program review meeting will be held Dec. 9-10 at L’Enfant Plaza. In addition to NSUF staff and users, NE-4, NE-5 and NE-7 representatives will attend the meeting. Awarded Research Projects Boise State University Rapid Turnaround Experiments (14-485 and 14-486) Nanoindentation and TEM work on the T91, HT9, HCM12A and 9Cr ODS specimens has been completed at CAES by Boise State PI Janelle Wharry and Cory Dolph. PI Corey Dolph returned in early November to complete their research by performing nanoindentation on unirradiated specimens that will be used as a baseline for their research.« less

  5. Retrospective cohort study exploring whether an association exists between spatial distribution of cystoid spaces in cystoid macular oedema secondary to retinitis pigmentosa and response to treatment with carbonic anhydrase inhibitors.

    PubMed

    Strong, Stacey A; Hirji, Nashila; Quartilho, Ana; Kalitzeos, Angelos; Michaelides, Michel

    2018-04-29

    Carbonic anhydrase inhibitors (CAIs) are frequently used as an initial step to treat retinitis pigmentosa-associated cystoid macular oedema (RP-CMO). Interestingly, it has been postulated that CAIs might reduce outer nuclear layer (ONL) fluid more effectively than inner nuclear layer (INL) fluid due to better access to retinal pigment epithelium basolateral membrane than neurosensory retina. This retrospective cohort study explores if an association between spatial distribution of cystoid spaces in RP-CMO and CAI response exists. Two independent graders reviewed pretreatment and post-treatment optical coherence tomography (OCT) images of 25 patients (43 eyes) initiated on topical and/or oral CAIs between January 2013 and December 2014. Documentation included the presence/absence of fluid (and layer(s) involved), external limiting membrane, epiretinal membrane (ERM), vitreomacular adhesion/traction, lamellar/full-thickness macular hole and central macular thickness (CMT)/volume. INL fluid was found in all study eyes. All 13 'responders' (at least 11% reduction of CMT after treatment) demonstrated pretreatment ONL fluid. In seven patients (four responders and three non-responders), complete clearance of ONL fluid was achieved despite persistence of INL fluid. ERM presence was similar in responders and non-responders. In this study, INL fluid was found to be the most common spatial distribution of RP-CMO. However, patients who were classed as a 'responder' to CAI treatment all demonstrated coexisting ONL fluid on their pretreatment OCT scans. This may be explained by CAIs having better access to retinal pigment epithelium basolateral membrane than neurosensory retina. Our study also suggests a minimal impact on response to CAIs by ERM. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  6. Listeria Monocytogenes Persistence in Ready-to-Eat Sausages and in Processing Plants

    PubMed Central

    Mureddu, Anna; Mazza, Roberta; Fois, Federica; Meloni, Domenico; Bacciu, Roberto; Piras, Francesca

    2014-01-01

    Listeria monocytogenes is of major concern in the fermented meat products and is able to persist in their processing environments. The aim of the present work was to evaluate the virulence profile and the persistence capacity of L. monocytogenes strains isolated in Sardinian fermented sausages processing plants. Food (ground meat, sausages at the end of acidification and ripening stage) and environmental samples (a total of n. 385), collected from 4 meat processing plants located in Sardinia (Italy), were examined to detect L. monocytogenes presence. All the L. monocytogenes isolates were identified by polymerase chain reaction (PCR) method. A subset of strains was also characterised by multiplex PCR-based serogrouping, using the lmo0737, lmo1118, ORF2819 and ORF2110 genes. Three different multiplex PCRs were used to obtain the virulence profiles by the rrn, hlyA, actA, prfA, inlA, inlB, iap, plcA, plcB and mpl marker genes. Furthermore, in vitro biofilm forming ability and resistance to disinfectants were carried out on microtiter plate. The overall prevalence was 31.5% in food, and 68.5% in environmental samples. The prevalent serotype resulted 1/2c (43%), followed by 1/2a (40%), 4b (8.6%), and 1/2b (8.6%). The amplification products of the virulence genes were found in all the isolates with the following prevalence: 77.1% hlyA; 100% rrn; 100% prfA; 97.1% iap; 65.7% inlB; 88.6% inlA; 100% plcA; 100% plcB and 74.3% mpl. As for biofilm forming ability, 37.1% of the strains were positive and resulted weak producer, but all the isolates were sensible to disinfectants showing a reduction of L. monocytogenes growth after each incubation time. More appropriate technologies and application of measures of hygienic control should be implemented to prevent the L. monocytogenes growth and cross-contamination in salsiccia sarda processing plants. PMID:27800316

  7. Listeria Monocytogenes Persistence in Ready-to-Eat Sausages and in Processing Plants.

    PubMed

    Mureddu, Anna; Mazza, Roberta; Fois, Federica; Meloni, Domenico; Bacciu, Roberto; Piras, Francesca; Mazzette, Rina

    2014-01-21

    Listeria monocytogenes is of major concern in the fermented meat products and is able to persist in their processing environments. The aim of the present work was to evaluate the virulence profile and the persistence capacity of L. monocytogenes strains isolated in Sardinian fermented sausages processing plants. Food (ground meat, sausages at the end of acidification and ripening stage) and environmental samples (a total of n. 385), collected from 4 meat processing plants located in Sardinia (Italy), were examined to detect L. monocytogenes presence. All the L. monocytogenes isolates were identified by polymerase chain reaction (PCR) method. A subset of strains was also characterised by multiplex PCR-based serogrouping, using the lmo0737 , lmo1118 , ORF2819 and ORF2110 genes. Three different multiplex PCRs were used to obtain the virulence profiles by the rrn , hlyA , actA , prfA , inlA , inlB , iap , plcA , plcB and mpl marker genes. Furthermore, in vitro biofilm forming ability and resistance to disinfectants were carried out on microtiter plate. The overall prevalence was 31.5% in food, and 68.5% in environmental samples. The prevalent serotype resulted 1/2c (43%), followed by 1/2a (40%), 4b (8.6%), and 1/2b (8.6%). The amplification products of the virulence genes were found in all the isolates with the following prevalence: 77.1% hlyA ; 100% rrn ; 100% prfA ; 97.1% iap ; 65.7% inlB ; 88.6% inlA ; 100% plcA ; 100% plcB and 74.3% mpl . As for biofilm forming ability, 37.1% of the strains were positive and resulted weak producer, but all the isolates were sensible to disinfectants showing a reduction of L. monocytogenes growth after each incubation time. More appropriate technologies and application of measures of hygienic control should be implemented to prevent the L. monocytogenes growth and cross-contamination in salsiccia sarda processing plants.

  8. Evaluate the role of organic acids in the protection of ligands from radiolytic degradation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, Anneka; Mezyk, Stehpen; Peterman, Dean

    In the Advanced TALSPEAK process, the bis(2-ethylhexyl)phosphoric acid (HDEHP) extractant used in the traditional TALSPEAK process is replaced by the extractant 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (HEH[EHP]). In addition, the aqueous phase complexant and buffer used in traditional TALSPEAK is replaced with the combination of N-(2-hydroxyethyl)ethylenediamine-N,N’,N’-triacetic acid (HEDTA) and citric acid. In order to evaluate the possible impacts of gamma radiolysis upon the efficacy of the Advanced TALSPEAK flowsheet, aqueous and organic phases corresponding to the extraction section of the proposed flowsheet were irradiated in the INL test loop under an ambient atmosphere. The results of these studies conducted at INL,more » led INL researchers to conclude that the scarcity of values of rate constants for the reaction of hydroxyl radical with the components of the Advanced TALSPEAK process chemistry was severely limiting the interpretation of the results of radiolysis studies performed at the INL. In this work, the rate of reaction of hydroxyl radical with citric acid at several pH values was measured using a competitive pulse radiolysis technique. This report describes those results and is written in completion of milestone M3FT-16IN030102028, the goal of which was to evaluate the role of organic acids in the protection of ligands from radiolytic degradation. The results reported here demonstrate the importance of obtaining hydroxyl radical reaction rate data for the conditions that closely resemble actual solution conditions expected to be used in an actual solvent extraction process. This report describes those results and is written in completion of milestone M3FT-16IN030102028, the goal of which was to evaluate the role of organic acids in the protection of ligands from radiolytic degradation.« less

  9. Radiological Monitoring Equipment For Real-Time Quantification Of Area Contamination In Soils And Facility Decommissioning

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    M. V. Carpenter; Jay A. Roach; John R Giles

    2005-09-01

    The environmental restoration industry offers several sys¬tems that perform scan-type characterization of radiologically contaminated areas. The Idaho National Laboratory (INL) has developed and deployed a suite of field systems that rapidly scan, characterize, and analyse radiological contamination in surface soils. The base system consists of a detector, such as sodium iodide (NaI) spectrometers, a global positioning system (GPS), and an integrated user-friendly computer interface. This mobile concept was initially developed to provide precertifica¬tion analyses of soils contaminated with uranium, thorium, and radium at the Fernald Closure Project, near Cincinnati, Ohio. INL has expanded the functionality of this basic system tomore » create a suite of integrated field-deployable analytical systems. Using its engineering and radiation measurement expertise, aided by computer hardware and software support, INL has streamlined the data acquisition and analysis process to provide real-time information presented on wireless screens and in the form of coverage maps immediately available to field technicians. In addition, custom software offers a user-friendly interface with user-selectable alarm levels and automated data quality monitoring functions that validate the data. This system is deployed from various platforms, depending on the nature of the survey. The deployment platforms include a small all-terrain vehicle used to survey large, relatively flat areas, a hand-pushed unit for areas where manoeuvrability is important, an excavator-mounted system used to scan pits and trenches where personnel access is restricted, and backpack- mounted systems to survey rocky shoreline features and other physical settings that preclude vehicle-based deployment. Variants of the base system include sealed proportional counters for measuring actinides (i.e., plutonium-238 and americium-241) in building demolitions, soil areas, roadbeds, and process line routes at the Miamisburg Closure Project near Dayton, Ohio. In addition, INL supports decontamination operations at the Oak Ridge National Laboratory.« less

  10. Adsorption Isotherms for Xenon and Krypton using INL HZ-PAN and AgZ-PAN Sorbents

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Garn, Troy G.; Greenhalgh, Mitchell; Rutledge, Veronica J.

    2014-08-01

    The generation of adsorption isotherms compliments the scale-up of off-gas processes used to control the emission of encapsulated radioactive volatile fission and activation products released during Used Nuclear Fuel (UNF) reprocessing activities. A series of experiments were conducted to obtain capacity results for varying Kr and Xe gas concentrations using HZ-PAN and AgZ-PAN engineered form sorbents. Gas compositions for Kr ranged from 150-40,000 ppmv and 250-5020 ppmv for Xe in a helium balance. The experiments were all performed at 220 K at a flowrate of 50 sccm. Acquired capacities were then respectively fit to the Langmuir equation using the Langmuirmore » linear regression method to obtain the equilibrium parameters Qmax and Keq. Generated experimental adsorption isotherms were then plotted with the Langmuir predicted isotherms to illustrate agreement between the two. The Langmuir parameters were provided for input into the OSPREY model to predict breakthrough of single component adsorption of Kr and Xe on HZ-PAN and AgZ-PAN sorbents at the experimental conditions tested. Kr and Xe capacities resulting from model breakthrough predictions were then compared to experimental capacities for model validation.« less

  11. Geochemistry of groundwater in the Beaver and Camas Creek drainage basins, eastern Idaho

    USGS Publications Warehouse

    Rattray, Gordon W.; Ginsbach, Michael L.

    2014-01-01

    The U.S. Geological Survey (USGS), in cooperation with the U.S. Department of Energy, is studying the fate and transport of waste solutes in the eastern Snake River Plain (ESRP) aquifer at the Idaho National Laboratory (INL) in eastern Idaho. This effort requires an understanding of the natural and anthropogenic geochemistry of groundwater at the INL and of the important physical and chemical processes controlling the geochemistry. In this study, the USGS applied geochemical modeling to investigate the geochemistry of groundwater in the Beaver and Camas Creek drainage basins, which provide groundwater recharge to the ESRP aquifer underlying the northeastern part of the INL. Data used in this study include petrology and mineralogy from 2 sediment and 3 rock samples, and water-quality analyses from 4 surface-water and 18 groundwater samples. The mineralogy of the sediment and rock samples was analyzed with X-ray diffraction, and the mineralogy and petrology of the rock samples were examined in thin sections. The water samples were analyzed for field parameters, major ions, silica, nutrients, dissolved organic carbon, trace elements, tritium, and the stable isotope ratios of hydrogen, oxygen, carbon, sulfur, and nitrogen. Groundwater geochemistry was influenced by reactions with rocks of the geologic terranes—carbonate rocks, rhyolite, basalt, evaporite deposits, and sediment comprised of all of these rocks. Agricultural practices near and south of Dubois and application of road anti-icing liquids on U.S. Interstate Highway 15 were likely sources of nitrate, chloride, calcium, and magnesium to groundwater. Groundwater geochemistry was successfully modeled in the alluvial aquifer in Camas Meadows and the ESRP fractured basalt aquifer using the geochemical modeling code PHREEQC. The primary geochemical processes appear to be precipitation or dissolution of calcite and dissolution of silicate minerals. Dissolution of evaporite minerals, associated with Pleistocene Lake Terreton, is an important contributor of solutes in the Mud Lake-Dubois area. Oxidation-reduction reactions are important influences on the chemistry of groundwater at Camas Meadows and the Camas National Wildlife Refuge. In addition, mixing of different groundwaters or surface water with groundwater appears to be an important physical process influencing groundwater geochemistry in much of the study area, and evaporation may be an important physical process influencing the groundwater geochemistry of the Camas National Wildlife Refuge. The mass-balance modeling results from this study provide an explanation of the natural geochemistry of groundwater in the ESRP aquifer northeast of the INL, and thus provide a starting point for evaluating the natural and anthropogenic geochemistry of groundwater at the INL.

  12. Improving Rangeland Monitoring and Assessment: Integrating Remote Sensing, GIS, and Unmanned Aerial Vehicle Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Robert Paul Breckenridge

    2007-05-01

    Creeping environmental changes are impacting some of the largest remaining intact parcels of sagebrush steppe ecosystems in the western United States, creating major problems for land managers. The Idaho National Laboratory (INL), located in southeastern Idaho, is part of the sagebrush steppe ecosystem, one of the largest ecosystems on the continent. Scientists at the INL and the University of Idaho have integrated existing field and remotely sensed data with geographic information systems technology to analyze how recent fires on the INL have influenced the current distribution of terrestrial vegetation. Three vegetation mapping and classification systems were used to evaluate themore » changes in vegetation caused by fires between 1994 and 2003. Approximately 24% of the sagebrush steppe community on the INL was altered by fire, mostly over a 5-year period. There were notable differences between methods, especially for juniper woodland and grasslands. The Anderson system (Anderson et al. 1996) was superior for representing the landscape because it includes playa/bare ground/disturbed area and sagebrush steppe on lava as vegetation categories. This study found that assessing existing data sets is useful for quantifying fire impacts and should be helpful in future fire and land use planning. The evaluation identified that data from remote sensing technologies is not currently of sufficient quality to assess the percentage of cover. To fill this need, an approach was designed using both helicopter and fixed wing unmanned aerial vehicles (UAVs) and image processing software to evaluate six cover types on field plots located on the INL. The helicopter UAV provided the best system compared against field sampling, but is more dangerous and has spatial coverage limitations. It was reasonably accurate for dead shrubs and was very good in assessing percentage of bare ground, litter and grasses; accuracy for litter and shrubs is questionable. The fixed wing system proved to be feasible and can collect imagery for very large areas in a short period of time. It was accurate for bare ground and grasses. Both UAV systems have limitations, but these will be reduced as the technology advances. In both cases, the UAV systems collected data at a much faster rate than possible on the ground. The study concluded that improvements in automating the image processing efforts would greatly improve use of the technology. In the near future, UAV technology may revolutionize rangeland monitoring in the same way Global Positioning Systems have affected navigation while conducting field activities.« less

  13. Use of SUSA in Uncertainty and Sensitivity Analysis for INL VHTR Coupled Codes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gerhard Strydom

    2010-06-01

    The need for a defendable and systematic Uncertainty and Sensitivity approach that conforms to the Code Scaling, Applicability, and Uncertainty (CSAU) process, and that could be used for a wide variety of software codes, was defined in 2008.The GRS (Gesellschaft für Anlagen und Reaktorsicherheit) company of Germany has developed one type of CSAU approach that is particularly well suited for legacy coupled core analysis codes, and a trial version of their commercial software product SUSA (Software for Uncertainty and Sensitivity Analyses) was acquired on May 12, 2010. This interim milestone report provides an overview of the current status of themore » implementation and testing of SUSA at the INL VHTR Project Office.« less

  14. Effects of alpha-lipoic acid on retinal ganglion cells, retinal thicknesses, and VEGF production in an experimental model of diabetes.

    PubMed

    Kan, Emrah; Alici, Ömer; Kan, Elif Kılıç; Ayar, Ahmet

    2017-12-01

    The purpose of the present study was to investigate the effect of alpha-lipoic acid (ALA) on the thicknesses of various retinal layers and on the numbers of retinal ganglion cells and vascular endothelial growth factor levels in experimental diabetic mouse retinas. Twenty-one male BALB/C mice were made diabetic by the intraperitoneal administration of streptozotocin (200 mg/kg). One week after the induction of diabetes, the mice were divided randomly into three groups: control group (non-diabetic mice treated with alpha-lipoic acid, n = 7), diabetic group (diabetic mice without treatment, n = 7), and alpha-lipoic acid treatment group (diabetic mice with alpha-lipoic acid treatment, n = 7). At the end of the 8th week, the thicknesses of the inner nuclear layer (INL), outer nuclear layer (ONL), and full-length retina were measured; also retinal ganglion cells and VEGF expressions were counted on the histological sections of the mouse retinas and compared with each other. The thicknesses of the full-length retina, ONL, and INL were significantly reduced in the diabetic group compared to the control and ALA treatment groups (p = 0.001), whereas the thicknesses of these layers did not show a significant difference between ALA treatment and control groups. The number of ganglion cells in the diabetic group was significantly lower than those in the control and ALA treatment groups (p = 0.001). The VEGF expression was significantly higher in the diabetic group and mostly observed in the ganglion cell and inner nuclear layers compared to the control and ALA treatment groups (p = 0.001). Therefore, the number of ganglion cells and VEGF levels did not show significant differences between the ALA treatment and control groups (p = 0.7). Our results show that alpha-lipoic acid treatment may have an impact on reducing VEGF levels, protecting ganglion cells, and preserving the thicknesses of the inner and outer layers in diabetic mouse retinas.

  15. Real-Time SCADA Cyber Protection Using Compression Techniques

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lyle G. Roybal; Gordon H Rueff

    2013-11-01

    The Department of Energy’s Office of Electricity Delivery and Energy Reliability (DOE-OE) has a critical mission to secure the energy infrastructure from cyber attack. Through DOE-OE’s Cybersecurity for Energy Delivery Systems (CEDS) program, the Idaho National Laboratory (INL) has developed a method to detect malicious traffic on Supervisory, Control, and Data Acquisition (SCADA) network using a data compression technique. SCADA network traffic is often repetitive with only minor differences between packets. Research performed at the INL showed that SCADA network traffic has traits desirable for using compression analysis to identify abnormal network traffic. An open source implementation of a Lempel-Ziv-Welchmore » (LZW) lossless data compression algorithm was used to compress and analyze surrogate SCADA traffic. Infected SCADA traffic was found to have statistically significant differences in compression when compared against normal SCADA traffic at the packet level. The initial analyses and results are clearly able to identify malicious network traffic from normal traffic at the packet level with a very high confidence level across multiple ports and traffic streams. Statistical differentiation between infected and normal traffic level was possible using a modified data compression technique at the 99% probability level for all data analyzed. However, the conditions tested were rather limited in scope and need to be expanded into more realistic simulations of hacking events using techniques and approaches that are better representative of a real-world attack on a SCADA system. Nonetheless, the use of compression techniques to identify malicious traffic on SCADA networks in real time appears to have significant merit for infrastructure protection.« less

  16. A HUMAN FACTORS ENGINEERING PROCESS TO SUPPORT HUMAN-SYSTEM INTERFACE DESIGN IN CONTROL ROOM MODERNIZATION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kovesdi, C.; Joe, J.; Boring, R.

    The primary objective of the United States (U.S.) Department of Energy (DOE) Light Water Reactor Sustainability (LWRS) program is to sustain operation of the existing commercial nuclear power plants (NPPs) through a multi-pathway approach in conducting research and development (R&D). The Advanced Instrumentation, Information, and Control (II&C) System Technologies pathway conducts targeted R&D to address aging and reliability concerns with legacy instrumentation and control (I&C) and other information systems in existing U.S. NPPs. Control room modernization is an important part following this pathway, and human factors experts at Idaho National Laboratory (INL) have been involved in conducting R&D to supportmore » migration of new digital main control room (MCR) technologies from legacy analog and legacy digital I&C. This paper describes a human factors engineering (HFE) process that supports human-system interface (HSI) design in MCR modernization activities, particularly with migration of old digital to new digital I&C. The process described in this work is an expansion from the LWRS Report INL/EXT-16-38576, and is a requirements-driven approach that aligns with NUREG-0711 requirements. The work described builds upon the existing literature by adding more detail around key tasks and decisions to make when transitioning from HSI Design into Verification and Validation (V&V). The overall objective of this process is to inform HSI design and elicit specific, measurable, and achievable human factors criteria for new digital technologies. Upon following this process, utilities should have greater confidence with transitioning from HSI design into V&V.« less

  17. Vertical Transmission of Listeria monocytogenes: Probing the Balance between Protection from Pathogens and Fetal Tolerance.

    PubMed

    Lamond, Nicole M; Freitag, Nancy E

    2018-05-25

    Protection of the developing fetus from pathogens is one of the many critical roles of the placenta. Listeria monocytogenes is one of a select number of pathogens that can cross the placental barrier and cause significant harm to the fetus, leading to spontaneous abortion, stillbirth, preterm labor, and disseminated neonate infection despite antibiotic treatment. Such severe outcomes serve to highlight the importance of understanding how L. monocytogenes mediates infiltration of the placental barrier. Here, we review what is currently known regarding vertical transmission of L. monocytogenes as a result of cell culture and animal models of infection. In vitro cell culture and organ models have been useful for the identification of L. monocytogenes virulence factors that contribute to placental invasion. Examples include members of the Internalin family of bacterial surface proteins such as Interalin (Inl)A, InlB, and InlP that promote invasion of cells at the maternal-fetal interface. A number of animal models have been used to interrogate L. monocytogenes vertical transmission, including mice, guinea pigs, gerbils, and non-human primates; each of these models has advantages while still not providing a comprehensive understanding of L. monocytogenes invasion of the human placenta and/or fetus. These models do, however, allow for the molecular investigation of the balance between fetal tolerance and immune protection from L. monocytogenes during pregnancy.

  18. Spatio-temporal assessment of soil erosion risk in different agricultural zones of the Inle Lake region, southern Shan State, Myanmar.

    PubMed

    Htwe, Thin Nwe; Brinkmann, Katja; Buerkert, Andreas

    2015-10-01

    Myanmar is one of Southeast Asia's climatically most diverse countries, where sheet, rill, and gully erosion affect crop yields and subsequently livelihood strategies of many people. In the unique wetland ecosystem of Inle Lake, soil erosion in surrounding uplands lead to sedimentation and pollution of the water body. The current study uses the Revised Universal Soil Loss Equation (RUSLE) to identify soil erosion risks of the Inle Lake region in space and time and to assess the relationship between soil erosion and degradation for different agricultural zones and cropping systems. Altogether, 85% of soil losses occurred on barren land along the steep slopes. The hotspot of soil erosion risk is situated in the western uplands characterized by unsustainable land use practices combined with a steep topography. The estimated average soil losses amounted to 19.9, 10.1, and 26.2 t ha(-1) yr(-1) in 1989, 2000, and 2009, respectively. These fluctuations were mainly the results of changes in precipitation and land cover (deforestation (-19%) and expansion of annual cropland (+35%) from 1989 to 2009). Most farmers in the study area have not yet adopted effective soil protection measures to mitigate the effects of soil erosion such as land degradation and water pollution of the lake reservoir. This urgently needs to be addressed by policy makers and extension services.

  19. Concrete Shield Performance of the VSC-17 Spent Nuclear Fuel Cask

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sheryl L. Morton; Philip L. Winston; Toshiari Saegusa

    2006-04-01

    In 2003, representatives from the Central Research Institute of Electric Power Industry (CRIEPI) requested development of a project with the objective of determining the performance of a concrete spent nuclear fuel storage cask. Radiation and environmental effects may cause chemical alteration of the concrete that could result in excessive cracking, spalling, and loss of compressive strength. The Idaho National Laboratory (INL) project team and CRIEPI representatives identified the Ventilated Storage Cask (VSC-17) spent nuclear fuel storage cask as a candidate to study cask performance, because it had been used to store fuel as part of a dry cask storage demonstrationmore » project for more than 15 years. The project involved investigating the properties of the concrete shield. INL performed a survey of the cask in the summers of 2003 and 2004. Preliminary cask evaluations performed in 2003 indicated that the cask has no visual degradation. However, a 4-5 mrem/hr step-change in the radiation levels about halfway up the cask and a localized hot spot beneath an upper air vent indicate that there may be variability in the density of the concrete or localized cracking. In 2005, INL and CRIEPI scientists performed additional surveys on the VSC-17 cask. This document summarizes the methods used on the VSC-17 to evaluate the cask for compressive strength, concrete cracking, concrete thickness, and temperature distribution.« less

  20. A 7.4 ps FPGA-Based TDC with a 1024-Unit Measurement Matrix

    PubMed Central

    Zhang, Min; Wang, Hai; Liu, Yan

    2017-01-01

    In this paper, a high-resolution time-to-digital converter (TDC) based on a field programmable gate array (FPGA) device is proposed and tested. During the implementation, a new architecture of TDC is proposed which consists of a measurement matrix with 1024 units. The utilization of routing resources as the delay elements distinguishes the proposed design from other existing designs, which contributes most to the device insensitivity to variations of temperature and voltage. Experimental results suggest that the measurement resolution is 7.4 ps, and the INL (integral nonlinearity) and DNL (differential nonlinearity) are 11.6 ps and 5.5 ps, which indicates that the proposed TDC offers high performance among the available TDCs. Benefitting from the FPGA platform, the proposed TDC has superiorities in easy implementation, low cost, and short development time. PMID:28420121

  1. A 7.4 ps FPGA-Based TDC with a 1024-Unit Measurement Matrix.

    PubMed

    Zhang, Min; Wang, Hai; Liu, Yan

    2017-04-14

    In this paper, a high-resolution time-to-digital converter (TDC) based on a field programmable gate array (FPGA) device is proposed and tested. During the implementation, a new architecture of TDC is proposed which consists of a measurement matrix with 1024 units. The utilization of routing resources as the delay elements distinguishes the proposed design from other existing designs, which contributes most to the device insensitivity to variations of temperature and voltage. Experimental results suggest that the measurement resolution is 7.4 ps, and the INL (integral nonlinearity) and DNL (differential nonlinearity) are 11.6 ps and 5.5 ps, which indicates that the proposed TDC offers high performance among the available TDCs. Benefitting from the FPGA platform, the proposed TDC has superiorities in easy implementation, low cost, and short development time.

  2. Idaho National Laboratory Quarterly Performance Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitchell, Lisbeth

    2014-11-01

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 60 reportable events (23 from the 4th Qtr FY14 and 37 from the prior three reporting quarters) as well as 58 other issue reports (including not reportable events and Significant Category A and B conditions) identified at INLmore » from July 2013 through October 2014. Battelle Energy Alliance (BEA) operates the INL under contract DE AC07 051D14517.« less

  3. Idaho National Laboratory Quarterly Occurrence Analysis - 3rd Quarter FY-2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitchell, Lisbeth Ann

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 73 reportable events (23 from the 3rd Qtr FY-16 and 50 from the prior three reporting quarters), as well as 45 other issue reports (including events found to be not reportable and Significant Category A and B conditions)more » identified at INL during the past 12 months (16 from this quarter and 29 from the prior three quarters).« less

  4. Idaho National Laboratory Quarterly Occurrence Analysis - 1st Quarter FY 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitchell, Lisbeth Ann

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 74 reportable events (16 from the 1st Qtr FY-16 and 58 from the prior three reporting quarters), as well as 35 other issue reports (including events found to be not reportable and Significant Category A and B conditions)more » identified at INL during the past 12 months (15 from this quarter and 20 from the prior three quarters).« less

  5. Idaho National Laboratory Quarterly Occurrence Analysis 4th Quarter FY 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitchell, Lisbeth Ann

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System, as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 84 reportable events (29 from the 4th quarter fiscal year 2016 and 55 from the prior three reporting quarters), as well as 39 other issue reports (including events found to be not reportable and Significant Category A and Bmore » conditions) identified at INL during the past 12 months (two from this quarter and 37 from the prior three quarters).« less

  6. Idaho National Laboratory Quarterly Occurrence Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitchell, Lisbeth Ann

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 85 reportable events (18 from the 4th Qtr FY-15 and 67 from the prior three reporting quarters), as well as 25 other issue reports (including events found to be not reportable and Significant Category A and B conditions)more » identified at INL during the past 12 months (8 from this quarter and 17 from the prior three quarters).« less

  7. Water-quality characteristics and trends for selected sites at and near the Idaho National Laboratory, Idaho, 1949-2009

    USGS Publications Warehouse

    Bartholomay, Roy C.; Davis, Linda C.; Fisher, Jason C.; Tucker, Betty J.; Raben, Flint A.

    2012-01-01

    The U.S. Geological Survey, in cooperation with the U.S. Department of Energy, analyzed water-quality data collected from 67 aquifer wells and 7 surface-water sites at the Idaho National Laboratory (INL) from 1949 through 2009. The data analyzed included major cations, anions, nutrients, trace elements, and total organic carbon. The analyses were performed to examine water-quality trends that might inform future management decisions about the number of wells to sample at the INL and the type of constituents to monitor. Water-quality trends were determined using (1) the nonparametric Kendall's tau correlation coefficient, p-value, Theil-Sen slope estimator, and summary statistics for uncensored data; and (2) the Kaplan-Meier method for calculating summary statistics, Kendall's tau correlation coefficient, p-value, and Akritas-Theil-Sen slope estimator for robust linear regression for censored data. Statistical analyses for chloride concentrations indicate that groundwater influenced by Big Lost River seepage has decreasing chloride trends or, in some cases, has variable chloride concentration changes that correlate with above-average and below-average periods of recharge. Analyses of trends for chloride in water samples from four sites located along the Big Lost River indicate a decreasing trend or no trend for chloride, and chloride concentrations generally are much lower at these four sites than those in the aquifer. Above-average and below-average periods of recharge also affect concentration trends for sodium, sulfate, nitrate, and a few trace elements in several wells. Analyses of trends for constituents in water from several of the wells that is mostly regionally derived groundwater generally indicate increasing trends for chloride, sodium, sulfate, and nitrate concentrations. These increases are attributed to agricultural or other anthropogenic influences on the aquifer upgradient of the INL. Statistical trends of chemical constituents from several wells near the Naval Reactors Facility may be influenced by wastewater disposal at the facility or by anthropogenic influence from the Little Lost River basin. Groundwater samples from three wells downgradient of the Power Burst Facility area show increasing trends for chloride, nitrate, sodium, and sulfate concentrations. The increases could be caused by wastewater disposal in the Power Burst Facility area. Some groundwater samples in the southwestern part of the INL and southwest of the INL show concentration trends for chloride and sodium that may be influenced by wastewater disposal. Some of the groundwater samples have decreasing trends that could be attributed to the decreasing concentrations in the wastewater from the late 1970s to 2009. The young fraction of groundwater in many of the wells is more than 20 years old, so samples collected in the early 1990s are more representative of groundwater discharged in the 1960s and 1970s, when concentrations in wastewater were much higher. Groundwater sampled in 2009 would be representative of the lower concentrations of chloride and sodium in wastewater discharged in the late 1980s. Analyses of trends for sodium in several groundwater samples from the central and southern part of the eastern Snake River aquifer show increasing trends. In most cases, however, the sodium concentrations are less than background concentrations measured in the aquifer. Many of the wells are open to larger mixed sections of the aquifer, and the increasing trends may indicate that the long history of wastewater disposal in the central part of the INL is increasing sodium concentrations in the groundwater.

  8. Results for Phase I of the IAEA Coordinated Research Program on HTGR Uncertainties

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Strydom, Gerhard; Bostelmann, Friederike; Yoon, Su Jong

    2015-01-01

    The quantification of uncertainties in design and safety analysis of reactors is today not only broadly accepted, but in many cases became the preferred way to replace traditional conservative analysis for safety and licensing analysis. The use of a more fundamental methodology is also consistent with the reliable high fidelity physics models and robust, efficient, and accurate codes available today. To facilitate uncertainty analysis applications a comprehensive approach and methodology must be developed and applied. High Temperature Gas-cooled Reactors (HTGR) has its own peculiarities, coated particle design, large graphite quantities, different materials and high temperatures that also require other simulationmore » requirements. The IAEA has therefore launched a Coordinated Research Project (CRP) on the HTGR Uncertainty Analysis in Modeling (UAM) in 2013 to study uncertainty propagation specifically in the HTGR analysis chain. Two benchmark problems are defined, with the prismatic design represented by the General Atomics (GA) MHTGR-350 and a 250 MW modular pebble bed design similar to the HTR-PM (INET, China). This report summarizes the contributions of the HTGR Methods Simulation group at Idaho National Laboratory (INL) up to this point of the CRP. The activities at INL have been focused so far on creating the problem specifications for the prismatic design, as well as providing reference solutions for the exercises defined for Phase I. An overview is provided of the HTGR UAM objectives and scope, and the detailed specifications for Exercises I-1, I-2, I-3 and I-4 are also included here for completeness. The main focus of the report is the compilation and discussion of reference results for Phase I (i.e. for input parameters at their nominal or best-estimate values), which is defined as the first step of the uncertainty quantification process. These reference results can be used by other CRP participants for comparison with other codes or their own reference results. The status on the Monte Carlo modeling of the experimental VHTRC facility is also discussed. Reference results were obtained for the neutronics stand-alone cases (Ex. I-1 and Ex. I-2) using the (relatively new) Monte Carlo code Serpent, and comparisons were performed with the more established Monte Carlo codes MCNP and KENO-VI. For the thermal-fluids stand-alone cases (Ex. I-3 and I-4) the commercial CFD code CFX was utilized to obtain reference results that can be compared with lower fidelity tools.« less

  9. DeepFocus Acoustic Microscope Transducer

    ScienceCinema

    Taylor, Steven; Kraft, Nancy

    2018-02-13

    A new nondestructive testing device being used to analyse nuclear fuel could reduce costs for manufacturing and other industry. For more information about INL research projects, visit http://www.facebook.com/idahonationallaboratory.

  10. Advanced Electron Microscopy and Micro analytical technique development and application for Irradiated TRISO Coated Particles from the AGR-1 Experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Van Rooyen, Isabella Johanna; Lillo, Thomas Martin; Wen, Haiming

    2017-01-01

    A series of up to seven irradiation experiments are planned for the Advanced Gas Reactor (AGR) Fuel Development and Quantification Program, with irradiation completed at the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) for the first experiment (i.e., AGR-1) in November 2009 for an effective 620 full power days. The objective of the AGR-1 experiment was primarily to provide lessons learned on the multi-capsule test train design and to provide early data on fuel performance for use in fuel fabrication process development and post-irradiation safety testing data at high temperatures. This report describes the advanced microscopy and micro-analysismore » results on selected AGR-1 coated particles.« less

  11. Low tritium partial pressure permeation system for mass transport measurement in lead lithium eutectic

    DOE PAGES

    Pawelko, R. J.; Shimada, M.; Katayama, K.; ...

    2015-11-28

    This paper describes a new experimental system designed to investigate tritium mass transfer properties in materials important to fusion technology. Experimental activities were carried out at the Safety and Tritium Applied Research (STAR) facility located at the Idaho National Laboratory (INL). The tritium permeation measurement system was developed as part of the Japan/US TITAN collaboration to investigate tritium mass transfer properties in liquid lead lithium eutectic (LLE) alloy. The experimental system is configured to measure tritium mass transfer properties at low tritium partial pressures. Initial tritium permeation scoping tests were conducted on a 1 mm thick α-Fe plate to determinemore » operating parameters and to validate the experimental technique. A second series of permeation tests was then conducted with the α-Fe plate covered with an approximately 8.5 mm layer of liquid lead lithium eutectic alloy (α-Fe/LLE). We present preliminary tritium permeation data for α-Fe and α-Fe/LLE at temperatures between 400 and 600°C and at tritium partial pressures between 1.7E-3 and 2.5 Pa in helium. Preliminary results for the α-Fe plate and α-Fe/LLE indicate that the data spans a transition region between the diffusion-limited regime and the surface-limited regime. In conclusion, additional data is required to determine the existence and range of a surface-limited regime.« less

  12. Rfinity

    ScienceCinema

    Aaron R. Turner

    2017-12-09

    An innovation that offers a low-cost, plug-n-play option that enables virtually any wireless telecommunications device to safely store sensitive personal information and perform secure transactions. INL researchers include Steven McCown, Aaron Turner, Kur

  13. Precision Nanoparticles

    ScienceCinema

    John Hemminger

    2017-12-09

    A revolutionary technology that efficiently produces nanoparticles in uniform and prescribed sizes (1-100 nanometers) using supercritical fluids. INL researcher Robert Fox was joined by Idaho State University researchers Rene Rodriquez and Joshua Pak in d

  14. Rfinity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aaron R. Turner

    An innovation that offers a low-cost, plug-n-play option that enables virtually any wireless telecommunications device to safely store sensitive personal information and perform secure transactions. INL researchers include Steven McCown, Aaron Turner, Kur

  15. INL Results for Phases I and III of the OECD/NEA MHTGR-350 Benchmark

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gerhard Strydom; Javier Ortensi; Sonat Sen

    2013-09-01

    The Idaho National Laboratory (INL) Very High Temperature Reactor (VHTR) Technology Development Office (TDO) Methods Core Simulation group led the construction of the Organization for Economic Cooperation and Development (OECD) Modular High Temperature Reactor (MHTGR) 350 MW benchmark for comparing and evaluating prismatic VHTR analysis codes. The benchmark is sponsored by the OECD's Nuclear Energy Agency (NEA), and the project will yield a set of reference steady-state, transient, and lattice depletion problems that can be used by the Department of Energy (DOE), the Nuclear Regulatory Commission (NRC), and vendors to assess their code suits. The Methods group is responsible formore » defining the benchmark specifications, leading the data collection and comparison activities, and chairing the annual technical workshops. This report summarizes the latest INL results for Phase I (steady state) and Phase III (lattice depletion) of the benchmark. The INSTANT, Pronghorn and RattleSnake codes were used for the standalone core neutronics modeling of Exercise 1, and the results obtained from these codes are compared in Section 4. Exercise 2 of Phase I requires the standalone steady-state thermal fluids modeling of the MHTGR-350 design, and the results for the systems code RELAP5-3D are discussed in Section 5. The coupled neutronics and thermal fluids steady-state solution for Exercise 3 are reported in Section 6, utilizing the newly developed Parallel and Highly Innovative Simulation for INL Code System (PHISICS)/RELAP5-3D code suit. Finally, the lattice depletion models and results obtained for Phase III are compared in Section 7. The MHTGR-350 benchmark proved to be a challenging simulation set of problems to model accurately, and even with the simplifications introduced in the benchmark specification this activity is an important step in the code-to-code verification of modern prismatic VHTR codes. A final OECD/NEA comparison report will compare the Phase I and III results of all other international participants in 2014, while the remaining Phase II transient case results will be reported in 2015.« less

  16. In Vivo Protection against Retinal Neurodegeneration by Sigma Receptor 1 Ligand (+)-Pentazocine

    PubMed Central

    Smith, Sylvia B.; Duplantier, Jennifer; Dun, Ying; Mysona, Barbara; Roon, Penny; Martin, Pamela M.; Ganapathy, Vadivel

    2008-01-01

    Purpose To evaluate the neuroprotective properties of the sigma receptor 1 (σR1) ligand, (+)-pentazocine in an in vivo model of retinal neurodegeneration. Methods Spontaneously diabetic Ins2Akita/+ and wild-type mice received intraperitoneal injections of (+)-pentazocine for 22 weeks beginning at diabetes onset. Retinal mRNA and protein were analyzed by RT-PCR and Western blot analysis. Retinal histologic sections were measured to determine total retinal thickness, thicknesses of inner-outer nuclear and plexiform layers (INL, ONL, IPL, INL), and the number of cell bodies in the ganglion cell layer (GCL). Immunolabeling experiments were performed using antibodies specific for 4-hydroxynonenal and nitrotyrosine, markers of lipid peroxidation, and reactive nitrogen species, respectively, and an antibody specific for vimentin to view radial Müller fibers. Results σR1 mRNA and protein levels in the Ins2Akita/+ retina were comparable to those in the wild-type, indicating that σR1 is an available target during the disease process. Histologic evaluation of eyes of Ins2Akita/+ mice showed disruption of retinal architecture. By 17 to 25 weeks after birth, Ins2Akita/+ mice demonstrated ∼30% and 25% decreases in IPL and INL thicknesses, respectively, and a 30% reduction in ganglion cells. In the (+)-pentazocine-treated group, retinas of Ins2Akita/+ mice showed remarkable preservation of retinal architecture; IPL and INL thicknesses of (+)-pentazocinetreated Ins2Akita/+ mouse retinas were within normal limits. The number of ganglion cells was 15.6 ± 1.5 versus 10.4 ± 1.2 cells/100 μm retinal length in (+)-pentazocine-treated versus nontreated mutant mice. Levels of nitrotyrosine and 4-hydroxynonenal increased in Ins2Akita/+ retinas, but were reduced in (+)-pentazocine-treated mice. Retinas of Ins2Akita/+ mice showed loss of the uniform organization of radial Müller fibers. Retinas of (+)-pentazocine-treated mice maintained the radial organization of glial processes. Conclusion Sustained (+)-pentazocine treatment in an in vivo model of retinal degeneration conferred significant neuroprotection, reduced evidence of oxidative stress, and preserved retinal architecture, suggesting that σR1 ligands are promising therapeutic agents for intervention in neurodegenerative diseases of the retina. PMID:18469181

  17. RAVEN User Manual

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mandelli, Diego; Rabiti, Cristian; Cogliati, Joshua Joseph

    2015-10-01

    RAVEN is a generic software framework to perform parametric and probabilistic analysis based on the response of complex system codes. The initial development was aimed to provide dynamic risk analysis capabilities to the Thermo-Hydraulic code RELAP-7, currently under development at the Idaho National Laboratory (INL). Although the initial goal has been fully accomplished, RAVEN is now a multi-purpose probabilistic and uncertainty quantification platform, capable to agnostically communicate with any system code. This agnosticism includes providing Application Programming Interfaces (APIs). These APIs are used to allow RAVEN to interact with any code as long as all the parameters that need tomore » be perturbed are accessible by inputs files or via python interfaces. RAVEN is capable of investigating the system response, and investigating the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused toward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. The development of RAVEN has started in 2012, when, within the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program, the need to provide a modern risk evaluation framework became stronger. RAVEN principal assignment is to provide the necessary software and algorithms in order to employ the concept developed by the Risk Informed Safety Margin Characterization (RISMC) program. RISMC is one of the pathways defined within the Light Water Reactor Sustainability (LWRS) program. In the RISMC approach, the goal is not just the individuation of the frequency of an event potentially leading to a system failure, but the closeness (or not) to key safety-related events. Hence, the approach is interested in identifying and increasing the safety margins related to those events. A safety margin is a numerical value quantifying the probability that a safety metric (e.g. for an important process such as peak pressure in a pipe) is exceeded under certain conditions. The initial development of RAVEN has been focused on providing dynamic risk assessment capability to RELAP-7, currently under development at the INL and, likely, future replacement of the RELAP5-3D code. Most the capabilities that have been implemented having RELAP-7 as principal focus are easily deployable for other system codes. For this reason, several side activaties are currently ongoing for coupling RAVEN with software such as RELAP5-3D, etc. The aim of this document is the explanation of the input requirements, focalizing on the input structure.« less

  18. RAVEN User Manual

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mandelli, Diego; Rabiti, Cristian; Cogliati, Joshua Joseph

    2016-02-01

    RAVEN is a generic software framework to perform parametric and probabilistic analysis based on the response of complex system codes. The initial development was aimed to provide dynamic risk analysis capabilities to the Thermo-Hydraulic code RELAP-7, currently under development at the Idaho National Laboratory (INL). Although the initial goal has been fully accomplished, RAVEN is now a multi-purpose probabilistic and uncertainty quantification platform, capable to agnostically communicate with any system code. This agnosticism includes providing Application Programming Interfaces (APIs). These APIs are used to allow RAVEN to interact with any code as long as all the parameters that need tomore » be perturbed are accessible by input files or via python interfaces. RAVEN is capable of investigating the system response, and investigating the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused toward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. The development of RAVEN started in 2012, when, within the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program, the need to provide a modern risk evaluation framework became stronger. RAVEN principal assignment is to provide the necessary software and algorithms in order to employ the concept developed by the Risk Informed Safety Margin Characterization (RISMC) program. RISMC is one of the pathways defined within the Light Water Reactor Sustainability (LWRS) program. In the RISMC approach, the goal is not just the individuation of the frequency of an event potentially leading to a system failure, but the closeness (or not) to key safety-related events. Hence, the approach is interested in identifying and increasing the safety margins related to those events. A safety margin is a numerical value quantifying the probability that a safety metric (e.g. for an important process such as peak pressure in a pipe) is exceeded under certain conditions. The initial development of RAVEN has been focused on providing dynamic risk assessment capability to RELAP-7, currently under development at the INL and, likely, future replacement of the RELAP5-3D code. Most the capabilities that have been implemented having RELAP-7 as principal focus are easily deployable for other system codes. For this reason, several side activates are currently ongoing for coupling RAVEN with software such as RELAP5-3D, etc. The aim of this document is the explanation of the input requirements, focusing on the input structure.« less

  19. RAVEN User Manual

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mandelli, Diego; Rabiti, Cristian; Cogliati, Joshua Joseph

    2017-03-01

    RAVEN is a generic software framework to perform parametric and probabilistic analy- sis based on the response of complex system codes. The initial development was aimed to provide dynamic risk analysis capabilities to the Thermo-Hydraulic code RELAP-7, currently under development at the Idaho National Laboratory (INL). Although the initial goal has been fully accomplished, RAVEN is now a multi-purpose probabilistic and uncer- tainty quantification platform, capable to agnostically communicate with any system code. This agnosticism includes providing Application Programming Interfaces (APIs). These APIs are used to allow RAVEN to interact with any code as long as all the parameters thatmore » need to be perturbed are accessible by inputs files or via python interfaces. RAVEN is capable of investigating the system response, and investigating the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused to- ward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. The development of RAVEN has started in 2012, when, within the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program, the need to provide a modern risk evaluation framework became stronger. RAVEN principal assignment is to provide the necessary software and algorithms in order to employ the concept developed by the Risk Informed Safety Margin Characterization (RISMC) program. RISMC is one of the pathways defined within the Light Water Reactor Sustainability (LWRS) program. In the RISMC approach, the goal is not just the individuation of the frequency of an event potentially leading to a system failure, but the closeness (or not) to key safety-related events. Hence, the approach is in- terested in identifying and increasing the safety margins related to those events. A safety margin is a numerical value quantifying the probability that a safety metric (e.g. for an important process such as peak pressure in a pipe) is exceeded under certain conditions. The initial development of RAVEN has been focused on providing dynamic risk assess- ment capability to RELAP-7, currently under develop-ment at the INL and, likely, future replacement of the RELAP5-3D code. Most the capabilities that have been implemented having RELAP-7 as principal focus are easily deployable for other system codes. For this reason, several side activates are currently ongoing for coupling RAVEN with soft- ware such as RELAP5-3D, etc. The aim of this document is the explaination of the input requirements, focalizing on the input structure.« less

  20. A Career in Nuclear Energy

    ScienceCinema

    Lambregts, Marsha

    2018-02-07

    Nuclear chemist Dr. Marsha Lambregts talks about the Center for Advanced Energy Studies and the benefits of a nuclear energy career. For more information about careers at INL, visit http://www.facebook.com/idahonationallaboratory.

  1. NSR&D Program Fiscal Year (FY) 2015 Call for Proposals Mitigation of Seismic Risk at Nuclear Facilities using Seismic Isolation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Coleman, Justin

    2015-02-01

    Seismic isolation (SI) has the potential to drastically reduce seismic response of structures, systems, or components (SSCs) and therefore the risk associated with large seismic events (large seismic event could be defined as the design basis earthquake (DBE) and/or the beyond design basis earthquake (BDBE) depending on the site location). This would correspond to a potential increase in nuclear safety by minimizing the structural response and thus minimizing the risk of material release during large seismic events that have uncertainty associated with their magnitude and frequency. The national consensus standard America Society of Civil Engineers (ASCE) Standard 4, Seismic Analysismore » of Safety Related Nuclear Structures recently incorporated language and commentary for seismically isolating a large light water reactor or similar large nuclear structure. Some potential benefits of SI are: 1) substantially decoupling the SSC from the earthquake hazard thus decreasing risk of material release during large earthquakes, 2) cost savings for the facility and/or equipment, and 3) applicability to both nuclear (current and next generation) and high hazard non-nuclear facilities. Issue: To date no one has evaluated how the benefit of seismic risk reduction reduces cost to construct a nuclear facility. Objective: Use seismic probabilistic risk assessment (SPRA) to evaluate the reduction in seismic risk and estimate potential cost savings of seismic isolation of a generic nuclear facility. This project would leverage ongoing Idaho National Laboratory (INL) activities that are developing advanced (SPRA) methods using Nonlinear Soil-Structure Interaction (NLSSI) analysis. Technical Approach: The proposed study is intended to obtain an estimate on the reduction in seismic risk and construction cost that might be achieved by seismically isolating a nuclear facility. The nuclear facility is a representative pressurized water reactor building nuclear power plant (NPP) structure. Figure 1: Project activities The study will consider a representative NPP reinforced concrete reactor building and representative plant safety system. This study will leverage existing research and development (R&D) activities at INL. Figure 1 shows the proposed study steps with the steps in blue representing activities already funded at INL and the steps in purple the activities that would be funded under this proposal. The following results will be documented: 1) Comparison of seismic risk for the non-seismically isolated (non-SI) and seismically isolated (SI) NPP, and 2) an estimate of construction cost savings when implementing SI at the site of the generic NPP.« less

  2. Further Development of Crack Growth Detection Techniques for US Test and Research Reactors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kohse, Gordon; Carpenter, David M.; Ostrovsky, Yakov

    One of the key issues facing Light Water Reactors (LWRs) in extending lifetimes beyond 60 years is characterizing the combined effect of irradiation and water chemistry on material degradation and failure. Irradiation Assisted Stress Corrosion Cracking (IASCC), in which a crack propagates in a susceptible material under stress in an aggressive environment, is a mechanism of particular concern. Full understanding of IASCC depends on real time crack growth data acquired under relevant irradiation conditions. Techniques to measure crack growth in actively loaded samples under irradiation have been developed outside the US - at the Halden Boiling Water Reactor, for example.more » Several types of IASCC tests have also been deployed at the MITR, including passively loaded crack growth measurements and actively loaded slow strain rate tests. However, there is not currently a facility available in the US to measure crack growth on actively loaded, pre-cracked specimens in LWR irradiation environments. A joint program between the Idaho National Laboratory (INL) and the Massachusetts Institute of Technology (MIT) Nuclear Reactor Laboratory (NRL) is currently underway to develop and demonstrate such a capability for US test and research reactors. Based on the Halden design, the samples will be loaded using miniature high pressure bellows and a compact loading mechanism, with crack length measured in real time using the switched Direct Current Potential Drop (DCPD) method. The basic design and initial mechanical testing of the load system and implementation of the DCPD method have been previously reported. This paper presents the results of initial autoclave testing at INL and the adaptation of the design for use in the high pressure, high temperature water loop at the MITR 6 MW research reactor, where an initial demonstration is planned in mid-2015. Materials considerations for the high pressure bellows are addressed. Design modifications to the loading mechanism required by the size constraints of the MITR water loop are described. The safety case for operation of the high pressure gas-driven bellows mechanism is also presented. Key issues are the design and response of systems to limit gas flow in the event of a high pressure gas leak in the in-core autoclave. Integrity of the autoclave must be maintained and reactivity effects due to voiding of the loop coolant must be shown to be within the reactor technical specifications. The technical development of the crack growth monitor for application in the INL Advanced Test Reactor or the MITR can act as a template for adaptation of this technology in other reactors. (authors)« less

  3. 77 FR 55813 - Transition of DOE-ID Public Reading Room

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... to the INL Research Library at 1776 Science Center Drive, Idaho Falls, ID 83401, beginning September... Library, 1776 Science Center Drive, Idaho Falls, ID 83401. FOR FURTHER INFORMATION CONTACT: Clayton...

  4. Idaho National Laboratory Quarterly Occurrence Analysis for the 1st Quarter FY2017

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mitchell, Lisbeth Ann

    This report is published quarterly by the Idaho National Laboratory (INL) Quality and Performance Management Organization. The Department of Energy (DOE) Occurrence Reporting and Processing System (ORPS), as prescribed in DOE Order 232.2, “Occurrence Reporting and Processing of Operations Information,” requires a quarterly analysis of events, both reportable and not reportable, for the previous 12 months. This report is the analysis of 82 reportable events (13 from the 1st quarter (Qtr) of fiscal year (FY) 2017 and 68 from the prior three reporting quarters), as well as 31 other issue reports (including events found to be not reportable and Significantmore » Category A and B conditions) identified at INL during the past 12 months (seven from this quarter and 24 from the prior three quarters).« less

  5. Radon in Soil Gas Above Bedrock Fracture Sets at the Shepley’s Hill Superfund Site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J.R. Giles; T.L. McLing; M.V. Carpenter

    2012-12-01

    The Idaho National Laboratory (INL) recently provided technical support for ongoing environmental remediation activities at the Shepley’s Hill remediation site near Devens, MA (Figure 1). The technical support was requested as follow-on work to an initial screening level radiation survey conducted in 2008. The purpose of the original study was to assess the efficacy of the INL-developed Backpack Sodium Iodide System (BaSIS) for detecting elevated areas of natural radioactivity due to the decay of radon-222 gases emanating from the underlying fracture sets. Although the results from the initial study were mixed, the BaSIS radiation surveys did confirm that exposed bedrockmore » outcrops have higher natural radioactivity than the surficial soils, thus a high potential for detecting elevated levels of radon and/or radon daughter products. (INL 2009) The short count times associated with the BaSIS measurements limited the ability of the system to respond to elevated levels of radioactivity from a subsurface source, in this instance radon gas emanating from fracture sets. Thus, it was postulated that a different methodology be employed to directly detect the radon in the soil gases. The CR-39 particle track detectors were investigated through an extensive literature and technology search. The relatively long deployment or “detection” time of several days, as well as the sensitivity of the measurement and robustness of the detectors made the CR-39 technology promising for deployment at the Shepley’s Hill site.« less

  6. Characterisation of InlA truncation in Listeria monocytogenes isolates from farm animals and human cases in the province of Quebec

    PubMed Central

    Fravalo, Philippe; Cherifi, Tamazight; Neira Feliciano, Kersti Dina; Letellier, Ann; Fairbrother, Julie-Hélène; Bekal, Sadjia

    2017-01-01

    The introduction of Listeria monocytogenes into the food production chain is a concern, with numerous grouped cases of listeriosis associated with milk-derived or pork-derived products have been documented. Management of this zoonotic pathogen considers all strains as an equal risk. Recently, a new perspective for characterisation of strain virulence was introduced with the discovery of the unaltered sequence of InlA as a determinant of strain virulence; this has also been reported as an infrequent finding among so-called environmental strains, that is, strains isolated from food or from surfaces in food industries. The aim of this study was to differentiate L monocytogenes strains isolated from animal cases versus those from human cases and to differentiate clinical strains from environmental ones using a Caenorhabditis elegans virulence testing model. In Quebec in 2013/2014, the surveillance of L monocytogenes clinical isolates registered a total of 20 strains of animal origin and 16 pulsed-field gel electrophoresis types isolated from human cases. The mixed PCR multiplex agglutination protocol used for geno-serotyping clearly discriminated genogroup IVB strains from bovine and human origins. The presence of a premature stop codon single nucleotide polymorphism in the inlA gene sequence in clinical strains and the identical behaviour of particular strains in the C elegans model are discussed in this paper from the perspective of industrial management of L monocytogenes risk. PMID:28761668

  7. Evaluation of Caco-2 cells response to Listeria monocytogenes virulence factors by RT-PCR.

    PubMed

    Xie, Manman; Ding, Chengchao; Guo, Liang; Chen, Guowei; Zeng, Haijuan; Liu, Qing

    2018-04-30

    Listeria monocytogenes expresses various virulence factors enabling the invasion and multiplying in host cells, and together induces cytokines transcription. In order to explore the relationship between virulence factors of L. monocytogenes wild-type EGD-e and cellular response in human colonic epithelial cell line(Caco-2), we constructed mutant strains with in-frame deletions of critical virulence genes of inlA, inlB, hly, actA and virulence regulatory factor prfA from EGD-e, respectively. Compared with EGD-e, mutant strains showed significantly decreased invasion and apoptosis in Caco-2 cells. However, mutant strains were capable to evoke cytokines transcription of interleukin-8 (IL-8), mononuclear chemoattractant protein-1 (MCP-1), tumor necrosis factor-a (TNF-a), interleukin-1β (IL-1β), interleukin-6 (IL-6) and CXCL-2 production in Caco-2 cells. Interestingly, EGD-e Δhly-infected Caco-2 cells showed a significant decrease of IL-6, IL-8 and MCP-1 transcription compared with EGD-e at 1 h post-infection. Simultaneously, EGD-e ΔinlB-infected cells showed a decrease in IL-6 transcription, while EGD-e ΔactA-infected cells reflected a decrease in MCP-1 transcription. Virulence genes play a role in inflammatory transcription, but the interaction between pathogenic bacteria and the host cells predominates in inflammatory transcription. Overall, the data showed cellular response of Caco-2 cells infected with EGD-e mutant strains. Copyright © 2018. Published by Elsevier Ltd.

  8. Feedstock Supply System Design and Economics for Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels: Conversion Pathway: Biological Conversion of Sugars to Hydrocarbons The 2017 Design Case

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kevin Kenney; Kara G. Cafferty; Jacob J. Jacobson

    The U.S. Department of Energy promotes the production of a range of liquid fuels and fuel blendstocks from lignocellulosic biomass feedstocks by funding fundamental and applied research that advances the state of technology in biomass collection, conversion, and sustainability. As part of its involvement in this program, the Idaho National Laboratory (INL) investigates the feedstock logistics economics and sustainability of these fuels. Between 2000 and 2012, INL conducted a campaign to quantify the economics and sustainability of moving biomass from standing in the field or stand to the throat of the biomass conversion process. The goal of this program wasmore » to establish the current costs based on conventional equipment and processes, design improvements to the current system, and to mark annual improvements based on higher efficiencies or better designs. The 2012 programmatic target was to demonstrate a delivered biomass logistics cost of $35/dry ton. This goal was successfully achieved in 2012 by implementing field and process demonstration unit-scale data from harvest, collection, storage, preprocessing, handling, and transportation operations into INL’s biomass logistics model. Looking forward to 2017, the programmatic target is to supply biomass to the conversion facilities at a total cost of $80/dry ton and on specification with in-feed requirements. The goal of the 2017 Design Case is to enable expansion of biofuels production beyond highly productive resource areas by breaking the reliance of cost-competitive biofuel production on a single, abundant, low-cost feedstock. If this goal is not achieved, biofuel plants are destined to be small and/or clustered in select regions of the country that have a lock on low-cost feedstock. To put the 2017 cost target into perspective of past accomplishments of the cellulosic ethanol pathway, the $80 target encompasses total delivered feedstock cost, including both grower payment and logistics costs, while meeting all conversion in-feed quality targets. The 2012 $35 programmatic target included only logistics costs with a limited focus on biomass quality« less

  9. Impacts Analyses Supporting the National Environmental Policy Act Environmental Assessment for the Resumption of Transient Testing Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schafer, Annette L.; Brown, LLoyd C.; Carathers, David C.

    2014-02-01

    This document contains the analysis details and summary of analyses conducted to evaluate the environmental impacts for the Resumption of Transient Fuel and Materials Testing Program. It provides an assessment of the impacts for the two action alternatives being evaluated in the environmental assessment. These alternatives are (1) resumption of transient testing using the Transient Reactor Test Facility (TREAT) at Idaho National Laboratory (INL) and (2) conducting transient testing using the Annular Core Research Reactor (ACRR) at Sandia National Laboratory in New Mexico (SNL/NM). Analyses are provided for radiologic emissions, other air emissions, soil contamination, and groundwater contamination that couldmore » occur (1) during normal operations, (2) as a result of accidents in one of the facilities, and (3) during transport. It does not include an assessment of the biotic, cultural resources, waste generation, or other impacts that could result from the resumption of transient testing. Analyses were conducted by technical professionals at INL and SNL/NM as noted throughout this report. The analyses are based on bounding radionuclide inventories, with the same inventories used for test materials by both alternatives and different inventories for the TREAT Reactor and ACRR. An upper value on the number of tests was assumed, with a test frequency determined by the realistic turn-around times required between experiments. The estimates provided for impacts during normal operations are based on historical emission rates and projected usage rates; therefore, they are bounding. Estimated doses for members of the public, collocated workers, and facility workers that could be incurred as a result of an accident are very conservative. They do not credit safety systems or administrative procedures (such as evacuation plans or use of personal protective equipment) that could be used to limit worker doses. Doses estimated for transportation are conservative and are based on transport of the bounding radiologic inventory that will be contained in any given test. The transportation analysis assumes all transports will contain the bounding inventory.« less

  10. Distributed Name Management.

    DTIC Science & Technology

    1985-02-01

    u)l that labelled "ill)" or inl thle electronic mnail cx anpk Ocisng the nuans *’se iider ’’ and " recipient’’ rather than "i’sender’’". and "reader

  11. EBR-I Tour

    ScienceCinema

    Miley, Don

    2018-04-16

    Sixty years ago, the first light bulb to be lit with nuclear energy got its juice right here in Idaho. Here's a virtual tour of the place where it all happened. To learn more visit http://www.inl.gov/ebr.

  12. EBR-I Tour

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miley, Don

    2011-06-01

    Sixty years ago, the first light bulb to be lit with nuclear energy got its juice right here in Idaho. Here's a virtual tour of the place where it all happened. To learn more visit http://www.inl.gov/ebr.

  13. Baseline Fracture Toughness and CGR testing of alloys X-750 and XM-19 (EPRI Phase I)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J. H. Jackson; S. P. Teysseyre

    2012-10-01

    The Advanced Test Reactor National Scientific User Facility (ATR NSUF) and Electric Power Research Institute (EPRI) formed an agreement to test representative alloys used as reactor structural materials as a pilot program toward establishing guidelines for future ATR NSUF research programs. This report contains results from the portion of this program established as Phase I (of three phases) that entails baseline fracture toughness, stress corrosion cracking (SCC), and tensile testing of selected materials for comparison to similar tests conducted at GE Global Research. The intent of this Phase I research program is to determine baseline properties for the materials ofmore » interest prior to irradiation, and to ensure comparability between laboratories using similar testing techniques, prior to applying these techniques to the same materials after having been irradiated at the Advanced Test Reactor (ATR). The materials chosen for this research are the nickel based super alloy X-750, and nitrogen strengthened austenitic stainless steel XM-19. A spare core shroud upper support bracket of alloy X-750 was purchased by EPRI from Southern Co. and a section of XM-19 plate was purchased by EPRI from GE-Hitachi. These materials were sectioned at GE Global Research and provided to INL.« less

  14. Baseline Fracture Toughness and CGR testing of alloys X-750 and XM-19 (EPRI Phase I)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J. H. Jackson; S. P. Teysseyre

    2012-02-01

    The Advanced Test Reactor National Scientific User Facility (ATR NSUF) and Electric Power Research Institute (EPRI) formed an agreement to test representative alloys used as reactor structural materials as a pilot program toward establishing guidelines for future ATR NSUF research programs. This report contains results from the portion of this program established as Phase I (of three phases) that entails baseline fracture toughness, stress corrosion cracking (SCC), and tensile testing of selected materials for comparison to similar tests conducted at GE Global Research. The intent of this Phase I research program is to determine baseline properties for the materials ofmore » interest prior to irradiation, and to ensure comparability between laboratories using similar testing techniques, prior to applying these techniques to the same materials after having been irradiated at the Advanced Test Reactor (ATR). The materials chosen for this research are the nickel based super alloy X-750, and nitrogen strengthened austenitic stainless steel XM-19. A spare core shroud upper support bracket of alloy X-750 was purchased by EPRI from Southern Co. and a section of XM-19 plate was purchased by EPRI from GE-Hitachi. These materials were sectioned at GE Global Research and provided to INL.« less

  15. Application of Frequency of Detection Methods in Design and Optimization of the INL Site Ambient Air Monitoring Network

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rood, Arthur S.; Sondrup, A. Jeffrey

    This report presents an evaluation of a hypothetical INL Site monitoring network and the existing INL air monitoring network using frequency of detection methods. The hypothetical network was designed to address the requirement in 40 CFR Part 61, Subpart H (2006) that “emissions of radionuclides to ambient air from U.S. DOE facilities shall not exceed those amounts that would cause any member of the public to receive in any year an effective dose equivalent exceeding 10 mrem/year.” To meet the requirement for monitoring only, “radionuclide releases that would result in an effective dose of 10% of the standard shall bemore » readily detectable and distinguishable from background.” Thus, the hypothetical network consists of air samplers placed at residence locations that surround INL and at other locations where onsite livestock grazing takes place. Two exposure scenarios were used in this evaluation: a resident scenario and a shepherd/rancher scenario. The resident was assumed to be continuously present at their residence while the shepherd/rancher was assumed to be present 24-hours at a fixed location on the grazing allotment. Important radionuclides were identified from annual INL radionuclide National Emission Standards for Hazardous Pollutants reports. Important radionuclides were defined as those that potentially contribute 1% or greater to the annual total dose at the radionuclide National Emission Standards for Hazardous Pollutants maximally exposed individual location and include H-3, Am-241, Pu-238, Pu 239, Cs-137, Sr-90, and I-131. For this evaluation, the network performance objective was set at achieving a frequency of detection greater than or equal to 95%. Results indicated that the hypothetical network for the resident scenario met all performance objectives for H-3 and I-131 and most performance objectives for Cs-137 and Sr-90. However, all actinides failed to meet the performance objectives for most sources. The shepherd/rancher scenario showed that air samplers placed around the facilities every 22.5 degrees were very effective in detecting releases, but this arrangement is not practical or cost effective. However, it was shown that a few air samplers placed in the prevailing wind direction around each facility could achieve the performance objective of a frequency of detection greater than or equal to 95% for the shepherd/rancher scenario. The results also indicate some of the current sampler locations have little or no impact on the network frequency of detection and could be removed from the network with no appreciable deterioration of performance. Results show that with some slight modifications to the existing network (i.e., additional samplers added north and south of the Materials and Fuels Complex and ineffective samplers removed), the network would achieve performance objectives for all sources for both the resident and shepherd/rancher scenario.« less

  16. WORKER STACKS GRAPHITE BLOCKS AGAINST INNER SOUTH WALL OF REACTOR. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WORKER STACKS GRAPHITE BLOCKS AGAINST INNER SOUTH WALL OF REACTOR. INL NEGATIVE NO. 3925. Unknown Photographer, 12/14/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  17. INL Researchers Advance Detection of Brucellosis

    ScienceCinema

    Roberto, Frank; Newby, Deborah

    2017-12-09

    What do cattle ranchers in the greater Yellowstone region have in common with British soldiers garrisoned on the island of Malta in the late 1800s? Hint: it's a pathogen that starts with the letter B. It's Brucella Abortus.

  18. EAST ELEVATION OF HIGH BAY ADDITION OF FUEL STORAGE BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST ELEVATION OF HIGH BAY ADDITION OF FUEL STORAGE BUILDING (CPP-603). INL DRAWING NUMBER 200-0603-00-706-051286. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  19. INL Researchers Advance Detection of Brucellosis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roberto, Frank; Newby, Deborah

    What do cattle ranchers in the greater Yellowstone region have in common with British soldiers garrisoned on the island of Malta in the late 1800s? Hint: it's a pathogen that starts with the letter B. It's Brucella Abortus.

  20. Construction diagrams, geophysical logs, and lithologic descriptions for boreholes USGS 103, 105, 108, 131, 135, NRF-15, and NRF-16, Idaho National Laboratory, Idaho

    USGS Publications Warehouse

    Hodges, Mary K.V.; Orr, Stephanie M.; Potter, Katherine E.; LeMaitre, Tynan

    2012-01-01

    This report, prepared in cooperation with the U.S. Department of Energy, summarizes construction, geophysical, and lithologic data collected from about 4,509 feet of core from seven boreholes deepened or drilled by the U.S. Geological Survey (USGS), Idaho National Laboratory (INL) Project Office, from 2006 to 2009 at the INL. USGS 103, 105, 108, and 131 were deepened and cored from 759 to 1,307 feet, 800 to 1,409 feet, 760 to 1,218 feet, and 808 to 1,239 feet, respectively. Boreholes USGS 135, NRF-15, and NRF-16 were drilled and continuously cored from land surface to 1,198, 759, and 425 feet, respectively. Cores were photographed and digitally logged by using commercially available software. Borehole descriptions summarize location, completion date, and amount and type of core recovered.

  1. Preliminary Options Assessment of Versatile Irradiation Test Reactor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sen, Ramazan Sonat

    The objective of this report is to summarize the work undertaken at INL from April 2016 to January 2017 and aimed at analyzing some options for designing and building a versatile test reactor; the scope of work was agreed upon with DOE-NE. Section 2 presents some results related to KNK II and PRISM Mod A. Section 3 presents some alternatives to the VCTR presented in [ ] as well as a neutronic parametric study to assess the minimum power requirement needed for a 235U metal fueled fast test reactor capable to generate a fast (>100 keV) flux of 4.0 xmore » 1015 n /cm2-s at the test location. Section 4 presents some results regarding a fundamental characteristic of test reactors, namely displacement per atom (dpa) in test samples. Section 5 presents the INL assessment of the ANL fast test reactor design FASTER. Section 6 presents a summary.« less

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jonathan Gray; Robert Anderson; Julio G. Rodriguez

    Abstract: Identifying and understanding digital instrumentation and control (I&C) cyber vulnerabilities within nuclear power plants and other nuclear facilities, is critical if nation states desire to operate nuclear facilities safely, reliably, and securely. In order to demonstrate objective evidence that cyber vulnerabilities have been adequately identified and mitigated, a testbed representing a facility’s critical nuclear equipment must be replicated. Idaho National Laboratory (INL) has built and operated similar testbeds for common critical infrastructure I&C for over ten years. This experience developing, operating, and maintaining an I&C testbed in support of research identifying cyber vulnerabilities has led the Korean Atomic Energymore » Research Institute of the Republic of Korea to solicit the experiences of INL to help mitigate problems early in the design, development, operation, and maintenance of a similar testbed. The following information will discuss I&C testbed lessons learned and the impact of these experiences to KAERI.« less

  3. An analysis of nuclear fuel burnup in the AGR-1 TRISO fuel experiment using gamma spectrometry, mass spectrometry, and computational simulation techniques

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harp, Jason M.; Demkowicz, Paul A.; Winston, Philip L.

    AGR 1 was the first in a series of experiments designed to test US TRISO fuel under high temperature gas-cooled reactor irradiation conditions. This experiment was irradiated in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) and is currently undergoing post irradiation examination (PIE) at INL and Oak Ridge National Laboratory. One component of the AGR 1 PIE is the experimental evaluation of the burnup of the fuel by two separate techniques. Gamma spectrometry was used to non destructively evaluate the burnup of all 72 of the TRISO fuel compacts that comprised the AGR 1 experiment. Two methodsmore » for evaluating burnup by gamma spectrometry were developed, one based on the Cs 137 activity and the other based on the ratio of Cs 134 and Cs 137 activities. Burnup values determined from both methods compared well with the values predicted from simulations. The highest measured burnup was 20.1% FIMA for the direct method and 20.0% FIMA for the ratio method (compared to 19.56% FIMA from simulations). An advantage of the ratio method is that the burnup of the cylindrical fuel compacts can determined in small (2.5 mm) axial increments and an axial burnup profile can be produced. Destructive chemical analysis by inductively coupled mass spectrometry (ICP MS) was then performed on selected compacts that were representative of the expected range of fuel burnups in the experiment to compare with the burnup values determined by gamma spectrometry. The compacts analyzed by mass spectrometry had a burnup range of 19.3% FIMA to 10.7% FIMA. The mass spectrometry evaluation of burnup for the four compacts agreed well with the gamma spectrometry burnup evaluations and the expected burnup from simulation. For all four compacts analyzed by mass spectrometry, the maximum range in the three experimentally determined values and the predicted value was 6% or less. Furthermore, the results confirm the accuracy of the nondestructive burnup evaluation from gamma spectrometry for TRISO fuel compacts across a burnup range of approximately 10 to 20% FIMA and also validate the approach used in the physics simulation of the AGR 1 experiment.« less

  4. An analysis of nuclear fuel burnup in the AGR-1 TRISO fuel experiment using gamma spectrometry, mass spectrometry, and computational simulation techniques

    DOE PAGES

    Harp, Jason M.; Demkowicz, Paul A.; Winston, Philip L.; ...

    2014-09-03

    AGR 1 was the first in a series of experiments designed to test US TRISO fuel under high temperature gas-cooled reactor irradiation conditions. This experiment was irradiated in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) and is currently undergoing post irradiation examination (PIE) at INL and Oak Ridge National Laboratory. One component of the AGR 1 PIE is the experimental evaluation of the burnup of the fuel by two separate techniques. Gamma spectrometry was used to non destructively evaluate the burnup of all 72 of the TRISO fuel compacts that comprised the AGR 1 experiment. Two methodsmore » for evaluating burnup by gamma spectrometry were developed, one based on the Cs 137 activity and the other based on the ratio of Cs 134 and Cs 137 activities. Burnup values determined from both methods compared well with the values predicted from simulations. The highest measured burnup was 20.1% FIMA for the direct method and 20.0% FIMA for the ratio method (compared to 19.56% FIMA from simulations). An advantage of the ratio method is that the burnup of the cylindrical fuel compacts can determined in small (2.5 mm) axial increments and an axial burnup profile can be produced. Destructive chemical analysis by inductively coupled mass spectrometry (ICP MS) was then performed on selected compacts that were representative of the expected range of fuel burnups in the experiment to compare with the burnup values determined by gamma spectrometry. The compacts analyzed by mass spectrometry had a burnup range of 19.3% FIMA to 10.7% FIMA. The mass spectrometry evaluation of burnup for the four compacts agreed well with the gamma spectrometry burnup evaluations and the expected burnup from simulation. For all four compacts analyzed by mass spectrometry, the maximum range in the three experimentally determined values and the predicted value was 6% or less. Furthermore, the results confirm the accuracy of the nondestructive burnup evaluation from gamma spectrometry for TRISO fuel compacts across a burnup range of approximately 10 to 20% FIMA and also validate the approach used in the physics simulation of the AGR 1 experiment.« less

  5. Advanced Test Reactor Core Modeling Update Project Annual Report for Fiscal Year 2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    David W. Nigg, Principal Investigator; Kevin A. Steuhm, Project Manager

    Legacy computational reactor physics software tools and protocols currently used for support of Advanced Test Reactor (ATR) core fuel management and safety assurance, and to some extent, experiment management, are inconsistent with the state of modern nuclear engineering practice, and are difficult, if not impossible, to properly verify and validate (V&V) according to modern standards. Furthermore, the legacy staff knowledge required for application of these tools and protocols from the 1960s and 1970s is rapidly being lost due to staff turnover and retirements. In late 2009, the Idaho National Laboratory (INL) initiated a focused effort, the ATR Core Modeling Updatemore » Project, to address this situation through the introduction of modern high-fidelity computational software and protocols. This aggressive computational and experimental campaign will have a broad strategic impact on the operation of the ATR, both in terms of improved computational efficiency and accuracy for support of ongoing DOE programs as well as in terms of national and international recognition of the ATR National Scientific User Facility (NSUF). The ATR Core Modeling Update Project, targeted for full implementation in phase with the next anticipated ATR Core Internals Changeout (CIC) in the 2014-2015 time frame, began during the last quarter of Fiscal Year 2009, and has just completed its third full year. Key accomplishments so far have encompassed both computational as well as experimental work. A new suite of stochastic and deterministic transport theory based reactor physics codes and their supporting nuclear data libraries (HELIOS, KENO6/SCALE, NEWT/SCALE, ATTILA, and an extended implementation of MCNP5) has been installed at the INL under various licensing arrangements. Corresponding models of the ATR and ATRC are now operational with all five codes, demonstrating the basic feasibility of the new code packages for their intended purpose. Of particular importance, a set of as-run core depletion HELIOS calculations for all ATR cycles since August 2009, Cycle 145A through Cycle 151B, was successfully completed during 2012. This major effort supported a decision late in the year to proceed with the phased incorporation of the HELIOS methodology into the ATR Core Safety Analysis Package (CSAP) preparation process, in parallel with the established PDQ-based methodology, beginning late in Fiscal Year 2012. Acquisition of the advanced SERPENT (VTT-Finland) and MC21 (DOE-NR) Monte Carlo stochastic neutronics simulation codes was also initiated during the year and some initial applications of SERPENT to ATRC experiment analysis were demonstrated. These two new codes will offer significant additional capability, including the possibility of full-3D Monte Carlo fuel management support capabilities for the ATR at some point in the future. Finally, a capability for rigorous sensitivity analysis and uncertainty quantification based on the TSUNAMI system has been implemented and initial computational results have been obtained. This capability will have many applications as a tool for understanding the margins of uncertainty in the new models as well as for validation experiment design and interpretation.« less

  6. I-NERI Annual Technical Progress Report 2007-004-K Development and Characterization of New High-Level Waste Forms for Achieving Waste Minimization from Pyroprocessing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    S. Frank

    The current method for the immobilization of fission products that accumulate in electrorefiner salt during the electrochemical processing of used metallic nuclear fuel is to encapsulate the electrorefiner salt in a glass-bonded sodalite ceramic waste form. This process was developed by Argonne National Laboratory in the USA and is currently performed at the Idaho National Laboratory for the treatment of Experimental Breeder Reactor-II (EBR-II) used fuel. This process utilizes a “once-through” option for the disposal of spent electrorefiner salt; where, after the treatment of the EBR-II fuel, the electrorefiner salt containing the active fission products will be disposed of inmore » the ceramic waste form (CWF). The CWF produced will have low fission product loading of approximately 2 to 5 weight percent due to the limited fuel inventory currently being processed. However; the design and implementation of advanced electrochemical processing facilities to treat used fuel would process much greater quantities fuel. With an advanced processing facility, it would be necessary to selectively remove fission products from the electrorefiner salt for salt recycle and to concentrate the fission products to reduce the volume of high-level waste from the treatment facility. The Korean Atomic Energy Research Institute and the Idaho National Laboratory have been collaborating on I-NERI research projects for a number of years to investigate both aspects of selective fission product separation from electrorefiner salt, and to develop advanced waste forms for the immobilization of the collected fission products. The first joint KAERI/INL I-NERI project titled: 2006-002-K, Separation of Fission Products from Molten LiCl-KCl Salt Used for Electrorefining of Metal Fuels, was successfully completed in 2009 by concentrating and isolating fission products from actual electrorefiner salt used for the treated used EBR-II fuel. Two separation methods were tested and from these tests were produced concentrated salt products that acted as the feed material for development of advanced waste forms investigated in this proposal. Accomplishments from the first year activities associated with this I-NERI project included the down selection of candidate waste forms to immobilize fission products separated from electrorefiner salt, and the design of equipment to fabricate actual waste forms in the Hot Fuels Examination Facility (HFEF) at the INL. Reported in this document are accomplishments from the second year (FY10) work performed at the INL, and includes the testing of waste form fabrication equipment, repeating the fission product precipitation experiment, and initial waste form fabrication efforts.« less

  7. Intraretinal hyperreflective foci on spectral-domain optical coherence tomographic images of patients with retinitis pigmentosa

    PubMed Central

    Kuroda, Masako; Hirami, Yasuhiko; Hata, Masayuki; Mandai, Michiko; Takahashi, Masayo; Kurimoto, Yasuo

    2014-01-01

    Background The purpose of this study was to observe the characteristic findings of spectral-domain optical coherence tomography (SD-OCT) images in the retinas of patients with retinitis pigmentosa and to evaluate their distribution patterns in the early and advanced stages of the disease. Methods A total of 184 patients (368 eyes) with retinitis pigmentosa were observed using SD-OCT. We studied the presence or absence of continuous inner/outer segment (IS/OS) lines, presence of thinning of the retinal pigment epithelium-Bruch’s membrane complex, and distribution patterns of hyperreflective foci in the inner and outer nuclear layers (INL and ONL). Results The IS/OS junction had partially disappeared in 275 eyes, which were at the early stage of retinitis pigmentosa (group X), whereas the junction had totally disappeared in 93, which were at the advanced stage of retinitis pigmentosa (group Y). Hyperreflective foci in the INL were observed in a significantly larger proportion of the eyes in group X than in group Y (90% versus 61%, P<0.001), but hyperreflective foci in the ONL were observed in a significantly larger proportion of eyes in group Y than in group X (100% versus 69%, P<0.001). Conclusion Hyperreflective foci in the INL were more frequently observed in retinas with the early stage of retinitis pigmentosa and hyperreflective foci in the ONL were more frequently observed in the advanced stage. Hyperreflective foci may be indicative of changes in the retinal structure at each stage of retinitis pigmentosa. PMID:24591813

  8. Polyphasic characterization and genetic relatedness of low-virulence and virulent Listeria monocytogenes isolates

    PubMed Central

    2012-01-01

    Background Currently, food regulatory authorities consider all Listeria monocytogenes isolates as equally virulent. However, an increasing number of studies demonstrate extensive variations in virulence and pathogenicity of L. monocytogenes strains. Up to now, there is no comprehensive overview of the population genetic structure of L. monocytogenes taking into account virulence level. We have previously demonstrated that different low-virulence strains exhibit the same mutations in virulence genes suggesting that they could have common evolutionary pathways. New low-virulence strains were identified and assigned to phenotypic and genotypic Groups using cluster analysis. Pulsed-field gel electrophoresis, virulence gene sequencing and multi-locus sequence typing analyses were performed to study the genetic relatedness and the population structure between the studied low-virulence isolates and virulent strains. Results These methods showed that low-virulence strains are widely distributed in the two major lineages, but some are also clustered according to their genetic mutations. These analyses showed that low-virulence strains initially grouped according to their lineage, then to their serotypes and after which, they lost their virulence suggesting a relatively recent emergence. Conclusions Loss of virulence in lineage II strains was related to point mutation in a few virulence genes (prfA, inlA, inlB, plcA). These strains thus form a tightly clustered, monophyletic group with limited diversity. In contrast, low-virulence strains of lineage I were more dispersed among the virulence strains and the origin of their loss of virulence has not been identified yet, even if some strains exhibited different mutations in prfA or inlA. PMID:23267677

  9. Review of the TREAT Conversion Conceptual Design and Fuel Qualification Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Diamond, David

    The U.S. Department of Energy (DOE) is preparing to re establish the capability to conduct transient testing of nuclear fuels at the Idaho National Laboratory (INL) Transient Reactor Test (TREAT) facility. The original TREAT core went critical in February 1959 and operated for more than 6,000 reactor startups before plant operations were suspended in 1994. DOE is now planning to restart the reactor using the plant's original high-enriched uranium (HEU) fuel. At the same time, the National Nuclear Security Administration (NNSA) Office of Material Management and Minimization Reactor Conversion Program is supporting analyses and fuel fabrication studies that will allowmore » for reactor conversion to low-enriched uranium (LEU) fuel (i.e., fuel with less than 20% by weight 235U content) after plant restart. The TREAT Conversion Program's objectives are to perform the design work necessary to generate an LEU replacement core, to restore the capability to fabricate TREAT fuel element assemblies, and to implement the physical and operational changes required to convert the TREAT facility to use LEU fuel.« less

  10. Submission of FeCrAl Feedstock for Support of AFC ATR-2 Irradiations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Field, Kevin G.; Barrett, Kristine E.; Sun, Zhiqian

    The Advanced Test Reactor (ATR) is currently being used to test accident tolerant fuel (ATF) forms destined for commercial nuclear power plant deployment. One irradiation program using the ATR for ATF concepts, Accident Tolerant Fuel-2 (ATF-2), is a water loop irradiation test using miniaturized fuel pins as test articles. This complicated testing configuration requires a series of pre-test experiments and verification including a flowing loop autoclave test and a sensor qualification test (SQT) prior to full test train deployment within the ATR. In support of the ATF-2 irradiation program, Oak Ridge National Laboratory (ORNL) has supplied two different Generation IImore » FeCrAl alloys in rod stock form to Idaho National Laboratory (INL). These rods will be machined into dummy pins for deployment in the autoclave test and SQT. Post-test analysis of the dummy pins will provide initial insight into the performance of Generation II FeCrAl alloys in the ATF-2 irradiation experiment as well as within a commercial nuclear reactor.« less

  11. LWRS ATR Irradiation Testing Readiness Status

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kristine Barrett

    2012-09-01

    The Light Water Reactor Sustainability (LWRS) Program was established by the U.S. Department of Energy Office of Nuclear Energy (DOE-NE) to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors. The LWRS Program is divided into four R&D Pathways: (1) Materials Aging and Degradation; (2) Advanced Light Water Reactor Nuclear Fuels; (3) Advanced Instrumentation, Information and Control Systems; and (4) Risk-Informed Safety Margin Characterization. This report describes an irradiation testing readiness analysis in preparation of LWRS experiments for irradiation testing at the Idaho National Laboratory (INL) Advanced Testmore » Reactor (ATR) under Pathway (2). The focus of the Advanced LWR Nuclear Fuels Pathway is to improve the scientific knowledge basis for understanding and predicting fundamental performance of advanced nuclear fuel and cladding in nuclear power plants during both nominal and off-nominal conditions. This information will be applied in the design and development of high-performance, high burn-up fuels with improved safety, cladding integrity, and improved nuclear fuel cycle economics« less

  12. GRAPHITE BLOCKS ARE ARRAYED IN "THERMAL COLUMN" ON NORTH SIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GRAPHITE BLOCKS ARE ARRAYED IN "THERMAL COLUMN" ON NORTH SIDE OF REACTOR. INL NEGATIVE NO. 4000. Unknown Photographer, 12/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  13. CONSTRUCTION PROGRESS PHOTO SHOWING WEST STORAGE BASIN AT FUEL STORAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO SHOWING WEST STORAGE BASIN AT FUEL STORAGE BUILDING (CPP-603). INL PHOTO NUMBER NRTS-51-689. Unknown Photographer, 1950 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  14. Motion-to-Energy (M2E) Power Generation Technology

    ScienceCinema

    INL

    2017-12-09

    INL researchers developed M2E, a new technology that converts motion to energy. M2E uses an innovative, optimized microgenerator with power management circuitry that kinetically charges mobile batteries from natural motion such as walking.

  15. MTR BASEMENT. GENERAL ELECTRIC CONTROL CONSOLE FOR AIRCRAFT NUCLEAR PROPULSION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR BASEMENT. GENERAL ELECTRIC CONTROL CONSOLE FOR AIRCRAFT NUCLEAR PROPULSION EXPERIMENT NO. 1. INL NEGATIVE NO. 6510. Unknown Photographer, 9/29/1959 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  16. PRECAST CONCRETE WALL PANELS ARE LIFTED INTO PLACE ON MTR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PRECAST CONCRETE WALL PANELS ARE LIFTED INTO PLACE ON MTR STEEL FRAME STRUCTURE. INL NEGATIVE NO. 1330. Unknown Photographer, 1/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  17. Genotypes Associated with Listeria monocytogenes Isolates Displaying Impaired or Enhanced Tolerances to Cold, Salt, Acid, or Desiccation Stress

    PubMed Central

    Hingston, Patricia; Chen, Jessica; Dhillon, Bhavjinder K.; Laing, Chad; Bertelli, Claire; Gannon, Victor; Tasara, Taurai; Allen, Kevin; Brinkman, Fiona S. L.; Truelstrup Hansen, Lisbeth; Wang, Siyun

    2017-01-01

    The human pathogen Listeria monocytogenes is a large concern in the food industry where its continuous detection in food products has caused a string of recalls in North America and Europe. Most recognized for its ability to grow in foods during refrigerated storage, L. monocytogenes can also tolerate several other food-related stresses with some strains possessing higher levels of tolerances than others. The objective of this study was to use a combination of phenotypic analyses and whole genome sequencing to elucidate potential relationships between L. monocytogenes genotypes and food-related stress tolerance phenotypes. To accomplish this, 166 L. monocytogenes isolates were sequenced and evaluated for their ability to grow in cold (4°C), salt (6% NaCl, 25°C), and acid (pH 5, 25°C) stress conditions as well as survive desiccation (33% RH, 20°C). The results revealed that the stress tolerance of L. monocytogenes is associated with serotype, clonal complex (CC), full length inlA profiles, and the presence of a plasmid which was identified in 55% of isolates. Isolates with full length inlA exhibited significantly (p < 0.001) enhanced cold tolerance relative to those harboring a premature stop codon (PMSC) in this gene. Similarly, isolates possessing a plasmid demonstrated significantly (p = 0.013) enhanced acid tolerance. We also identified nine new L. monocytogenes sequence types, a new inlA PMSC, and several connections between CCs and the presence/absence or variations of specific genetic elements. A whole genome single-nucleotide-variants phylogeny revealed sporadic distribution of tolerant isolates and closely related sensitive and tolerant isolates, highlighting that minor genetic differences can influence the stress tolerance of L. monocytogenes. Specifically, a number of cold and desiccation sensitive isolates contained PMSCs in σB regulator genes (rsbS, rsbU, rsbV). Collectively, the results suggest that knowing the sequence type of an isolate in addition to screening for the presence of full-length inlA and a plasmid, could help food processors and food agency investigators determine why certain isolates might be persisting in a food processing environment. Additionally, increased sequencing of L. monocytogenes isolates in combination with stress tolerance profiling, will enhance the ability to identify genetic elements associated with higher risk strains. PMID:28337186

  18. DEGRADATION ISSUES IN SOLID OXIDE CELLS DURING HIGH TEMPERATURE ELECTROLYSIS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    M. S. Sohal; J. E. O'Brien; C. M. Stoots

    2012-02-01

    Idaho National Laboratory (INL) is performing high-temperature electrolysis research to generate hydrogen using solid oxide electrolysis cells (SOECs). The project goals are to address the technical and degradation issues associated with the SOECs. This paper provides a summary of various ongoing INL and INL sponsored activities aimed at addressing SOEC degradation. These activities include stack testing, post-test examination, degradation modeling, and a list of issues that need to be addressed in future. Major degradation issues relating to solid oxide fuel cells (SOFC) are relatively better understood than those for SOECs. Some of the degradation mechanisms in SOFCs include contact problemsmore » between adjacent cell components, microstructural deterioration (coarsening) of the porous electrodes, and blocking of the reaction sites within the electrodes. Contact problems include delamination of an electrode from the electrolyte, growth of a poorly (electronically) conducting oxide layer between the metallic interconnect plates and the electrodes, and lack of contact between the interconnect and the electrode. INL's test results on high temperature electrolysis (HTE) using solid oxide cells do not provide a clear evidence whether different events lead to similar or drastically different electrochemical degradation mechanisms. Post-test examination of the solid oxide electrolysis cells showed that the hydrogen electrode and interconnect get partially oxidized and become non-conductive. This is most likely caused by the hydrogen stream composition and flow rate during cool down. The oxygen electrode side of the stacks seemed to be responsible for the observed degradation due to large areas of electrode delamination. Based on the oxygen electrode appearance, the degradation of these stacks was largely controlled by the oxygen electrode delamination rate. University of Utah (Virkar) has developed a SOEC model based on concepts in local thermodynamic equilibrium in systems otherwise in global thermodynamic non-equilibrium. This model is under continued development. It shows that electronic conduction through the electrolyte, however small, must be taken into account for determining local oxygen chemical potential, within the electrolyte. The chemical potential within the electrolyte may lie out of bounds in relation to values at the electrodes in the electrolyzer mode. Under certain conditions, high pressures can develop in the electrolyte just under the oxygen electrode (anode)/electrolyte interface, leading to electrode delamination. This theory is being further refined and tested by introducing some electronic conduction in the electrolyte.« less

  19. Enabling fast charging – Introduction and overview

    DOE PAGES

    Michelbacher, Christopher; Ahmed, Shabbir; Bloom, Ira; ...

    2017-10-23

    Argonne National Laboratory (Argonne), Idaho National Laboratory (INL), and the National Renewable Energy Laboratory (NREL), with guidance from VTO, initiated this study to understand the technical, cost, infrastructure, and implementation barriers associated with high rate charging up to 350 kW.

  20. CONSTRUCTION PROGRESS PHOTO SHOWING EXCAVATION PIT FOR MAIN PROCESSING BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO SHOWING EXCAVATION PIT FOR MAIN PROCESSING BUILDING (CPP-601) LOOKING SOUTH. INL PHOTO NUMBER NRTS-50-693. Unknown Photographer, 1950 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  1. CONSTRUCTION VIEW FUEL STORAGE BUILDING (CPP603) LOOKING EAST SHOWING ASBESTOS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION VIEW FUEL STORAGE BUILDING (CPP-603) LOOKING EAST SHOWING ASBESTOS SIDING. INL PHOTO NUMBER NRTS-51-1543. Unknown Photographer, 2/28/1951 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  2. CONSTRUCTION PROGRESS PHOTO SHOWING MAIN PROCESSING BUILDING (CPP601) LOOKING NORTH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO SHOWING MAIN PROCESSING BUILDING (CPP-601) LOOKING NORTH. INL PHOTO NUMBER NRTS-51-1387. Unknown Photographer, 1/31/1951 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  3. CONSTRUCTION PROGRESS PHOTO SHOWING FUEL STORAGE BUILDING (CPP603) LOOKING NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO SHOWING FUEL STORAGE BUILDING (CPP-603) LOOKING NORTHWEST. INL PHOTO NUMBER NRTS-50-895. Unknown Photographer, 10/30/1950 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  4. CONSTRUCTION PROGRESS PHOTO OF REMOTE ANALYTICAL FACILITY (CPP627) SHOWING INITIAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO OF REMOTE ANALYTICAL FACILITY (CPP-627) SHOWING INITIAL EXCAVATION. INL PHOTO NUMBER NRTS-54-10703. Unknown Photographer, 5/21/1954 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  5. Feedstock Interface Fy2017 Q3 Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carpenter, Danny; Howe, Daniel; Westover, Tyler

    This report summarized the results obtained in FY2017 Q3 of a collaborative effort between researchers at NREL, PNNL, and INL to develop rapid screening methods and models to predict the fact pyrolysis conversion performance of a range of biomass materials.

  6. Multiphysics Object-Oriented Simulation Environment (MOOSE)

    ScienceCinema

    None

    2017-12-09

    Nuclear reactor operators can expand safety margins with more precise information about how materials behave inside operating reactors. INL's new simulation platform makes such studies easier & more informative by letting researchers "plug-n-play" their mathematical models, skipping years of computer code development.

  7. A readout integrated circuit based on DBI-CTIA and cyclic ADC for MEMS-array-based focal plane

    NASA Astrophysics Data System (ADS)

    Miao, Liu; Dong, Wu; Zheyao, Wang

    2016-11-01

    A readout integrated circuit (ROIC) for a MEMS (microelectromechanical system)-array-based focal plane (MAFP) intended for imaging applications is presented. The ROIC incorporates current sources for diode detectors, scanners, timing sequence controllers, differential buffered injection-capacitive trans-impedance amplifier (DBI-CTIA) and 10-bit cyclic ADCs, and is integrated with MAFP using 3-D integration technology. A small-signal equivalent model is built to include thermal detectors into circuit simulations. The biasing current is optimized in terms of signal-to-noise ratio and power consumption. Layout design is tailored to fulfill the requirements of 3-D integration and to adapt to the size of MAFP elements, with not all but only the 2 bottom metal layers to complete nearly all the interconnections in DBI-CTIA and ADC in a 40 μm wide column. Experimental chips are designed and fabricated in a 0.35 μm CMOS mixed signal process, and verified in a code density test of which the results indicate a (0.29/-0.31) LSB differential nonlinearity (DNL) and a (0.61/-0.45) LSB integral nonlinearity (INL). Spectrum analysis shows that the effective number of bits (ENOB) is 9.09. The ROIC consumes 248 mW of power at most if not to cut off quiescent current paths when not needed. Project supported by by National Natural Science Foundation of China (No. 61271130), the Beijing Municipal Science and Tech Project (No. D13110100290000), the Tsinghua University Initiative Scientific Research Program (No. 20131089225), and the Shenzhen Science and Technology Development Fund (No. CXZZ20130322170740736).

  8. Modifications to the Fission Surface Power Primary Test Circuit (FSP-PTC)

    NASA Technical Reports Server (NTRS)

    Garber, Anne E.

    2008-01-01

    An actively pumped alkali metal flow circuit, designed and fabricated at the NASA Marshall Space Flight Center, underwent a range of tests at MSFC in early 2007. During this period, system transient responses and the performance of the liquid metal pump were evaluated. In May of 2007, the circuit was drained and cleaned to prepare for multiple modifications: the addition of larger upper and lower reservoirs, the installation of an annular linear induction pump (ALIP), and the inclusion of a closeable orifice in the test section. Modifications are now complete and testing has resumed. Performance of the ALIp, provided by Idaho National Laboratory (INL), is the subject of the first round ofexperimentation. This paper provides a summary of the tests conducted on the original circuit, details the physical changes that have since been made to it, and describes the current test program.

  9. FY 2013 INL SITE SUSTAINABILITY PLAN WITH THE FY 2012 ANNUAL REPORT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ernest L. Fossum; Steve A. Birrer

    2012-12-01

    It is the policy of the Department of Energy (DOE) that sustainable energy and transportation fuels management will be integrated into DOE operations to meet obligations under Executive Order (EO) 13423 "Strengthening Federal Environmental, Energy, and Transportation Management," the Instructions for Implementation of EO 13423, as well as Guidance Documents issued in accordance thereto and any modifcations or amendments that may be issued from time to time. In furtherance of this obligation, DOE established strategic performance-based energy and transportation fuels goals and strategies through the Transformational Energy Action Management (TEAM) Initiative, which were incorporated into DOE Order 430.2B "Departmental Energy,more » Renewable energy, and Transportation Management" and were also identified in DOE Order 450.1A, "Environmental Protection Program." These goals and accompanying strategies are to be implemented by DOE sites through the integration of energy and transportation fuels management into site Environmental Management Systems (EMS).« less

  10. MTR CONTROL ROOM WITH CONTROL CONSOLE AND STATUS READOUTS ALONG ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR CONTROL ROOM WITH CONTROL CONSOLE AND STATUS READOUTS ALONG WALL. WORKERS MAKE ELECTRICAL AND OTHER CONNECTIONS. INL NEGATIVE NO. 4289. Unknown Photographer, 2/26/1952 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  11. SOUTH WING, TRA661. SOUTH SIDE. CAMERA FACING NORTH. MTR HIGH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH WING, TRA-661. SOUTH SIDE. CAMERA FACING NORTH. MTR HIGH BAY BEYOND. INL NEGATIVE NO. HD46-45-3. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  12. ETR HEAT EXCHANGER BUILDING, TRA644. WORKERS ARE INSTALLING HEAT EXCHANGER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR HEAT EXCHANGER BUILDING, TRA-644. WORKERS ARE INSTALLING HEAT EXCHANGER PIPING. INL NEGATIVE NO. 56-3122. Jack L. Anderson, Photographer, 9/21/1956 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  13. MISCELLANEOUS ARCHITECTURAL DETAILS AND SECTIONS OF REMOTE ANALYTICAL FACILITY (CPP627). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MISCELLANEOUS ARCHITECTURAL DETAILS AND SECTIONS OF REMOTE ANALYTICAL FACILITY (CPP-627). INL DRAWING NUMBER 200-0627-00-098-105632. ALTERNATE ID NUMBER 4272-814-135. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  14. CONSTRUCTION PROGRESS PHOTO SHOWING EXCAVATION PIT FOR MAIN PROCESSING BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO SHOWING EXCAVATION PIT FOR MAIN PROCESSING BUILDING (CPP-601) LOOKING NORTHWEST. INL PHOTO NUMBER NRTS-50-885. Unknown Photographer, 10/30/1950 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  15. MTR AND ETR COMPLEXES. CAMERA FACING EASTERLY TOWARD CHEMICAL PROCESSING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR AND ETR COMPLEXES. CAMERA FACING EASTERLY TOWARD CHEMICAL PROCESSING PLANT. MTR AND ITS ATTACHMENTS IN FOREGROUND. ETR BEYOND TO RIGHT. INL NEGATIVE NO. 56-4100. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  16. WEST ELEVATION OF FUEL STORAGE BUILDING (CPP603). PHOTO TAKEN LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WEST ELEVATION OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING NORTHEAST. INL PHOTO NUMBER HD-54-20-1. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  17. AERIAL VIEW OF MAIN PROCESSING BUILDING SHOWING CONSTRUCTION PROGRESS AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    AERIAL VIEW OF MAIN PROCESSING BUILDING SHOWING CONSTRUCTION PROGRESS AND EXCAVATION FOR LABORATORY ON LEFT. INL PHOTO NUMBER NRTS-51-1759. Unknown Photographer, 3/28/1951 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  18. INTERIOR PHOTO OF THE REMOTE ANALYTICAL FACILITY OF SHIELDED GLOVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR PHOTO OF THE REMOTE ANALYTICAL FACILITY OF SHIELDED GLOVE BOXES IN OPERATING CORRIDOR (CPP-627). INL PHOTO NUMBER NRTS-55-1524. Unknown Photographer, 1955 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  19. CONSTRUCTION PROGRESS PHOTO SHOWING EMPLACEMENT STEEL BEAMS FUEL STORAGE BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO SHOWING EMPLACEMENT STEEL BEAMS FUEL STORAGE BUILDING (CPP-603) LOOKING EAST. INL PHOTO NUMBER NRTS-51-1371. Unknown Photographer, 1/31/1951 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  20. INTERIOR VIEW OF FUEL STORAGE BUILDING (CPP603) SHOWING CRANE ASSEMBLY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR VIEW OF FUEL STORAGE BUILDING (CPP-603) SHOWING CRANE ASSEMBLY FOR TRANSFER PIT. INL PHOTO NUMBER NRTS-51-2404. Unknown Photographer, 5/31/1951 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  1. PLAN VIEW OF FUEL STORAGE BUILDING (CPP603) SHOWING STORAGE BASINS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PLAN VIEW OF FUEL STORAGE BUILDING (CPP-603) SHOWING STORAGE BASINS. INL DRAWING NUMBER 200-0603-00-706-051285. ALTERNATE ID NUMBER CPP-D-1285. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  2. WEST ELEVATION OF FUEL STORAGE BUILDING (CPP603). PHOTO TAKEN LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WEST ELEVATION OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING NORTHEAST. INL PHOTO NUMBER HD-54-20-3. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  3. CONSTRUCTION PROGRESS PHOTO OF REMOTE ANALYTICAL FACILITY (CPP627) SHOWING PLACEMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO OF REMOTE ANALYTICAL FACILITY (CPP-627) SHOWING PLACEMENT OF PIERS. INL PHOTO NUMBER NRTS-54-11716. Unknown Photographer, 8/20/1954 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  4. ETR COMPRESSOR BUILDING, TRA643. COMPRESSORS AND OTHER EQUIPMENT INSTALLED. METAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR COMPRESSOR BUILDING, TRA-643. COMPRESSORS AND OTHER EQUIPMENT INSTALLED. METAL ROOF AND CONCRETE BLOCK WALLS. INL NEGATIVE NO. 61-4536. Unknown Photographer, ca. 1961. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  5. Viability of Existing INL Facilities for Dry Storage Cask Handling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Randy Bohachek; Charles Park; Bruce Wallace

    2013-04-01

    This report evaluates existing capabilities at the INL to determine if a practical and cost effective method could be developed for opening and handling full-sized dry storage casks. The Idaho Nuclear Technology and Engineering Center (INTEC) CPP-603, Irradiated Spent Fuel Storage Facility, provides the infrastructure to support handling and examining casks and their contents. Based on a reasonable set of assumptions, it is possible to receive, open, inspect, remove samples, close, and reseal large bolted-lid dry storage casks at the INL. The capability can also be used to open and inspect casks that were last examined at the TAN Hotmore » Shop over ten years ago. The Castor V/21 and REA-2023 casks can provide additional confirmatory information regarding the extended performance of low-burnup (<45 GWD/MTU) used nuclear fuel. Once a dry storage cask is opened inside CPP-603, used fuel retrieved from the cask can be packaged in a shipping cask, and sent to a laboratory for testing. Testing at the INL’s Materials and Fuels Complex (MFC) can occur starting with shipment of samples from CPP-603 over an on-site road, avoiding the need to use public highways. This reduces cost and reduces the risk to the public. The full suite of characterization methods needed to establish the condition of the fuel exists and MFC. Many other testing capabilities also exist at MFC, but when those capabilities are not adequate, samples can be prepared and shipped to other laboratories for testing. This report discusses how the casks would be handled, what work needs to be done to ready the facilities/capabilities, and what the work will cost.« less

  6. Viability of Existing INL Facilities for Dry Storage Cask Handling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bohachek, Randy; Wallace, Bruce; Winston, Phil

    2013-04-30

    This report evaluates existing capabilities at the INL to determine if a practical and cost effective method could be developed for opening and handling full-sized dry storage casks. The Idaho Nuclear Technology and Engineering Center (INTEC) CPP-603, Irradiated Spent Fuel Storage Facility, provides the infrastructure to support handling and examining casks and their contents. Based on a reasonable set of assumptions, it is possible to receive, open, inspect, remove samples, close, and reseal large bolted-lid dry storage casks at the INL. The capability can also be used to open and inspect casks that were last examined at the TAN Hotmore » Shop over ten years ago. The Castor V/21 and REA-2023 casks can provide additional confirmatory information regarding the extended performance of low-burnup (<45 GWD/MTU) used nuclear fuel. Once a dry storage cask is opened inside CPP-603, used fuel retrieved from the cask can be packaged in a shipping cask, and sent to a laboratory for testing. Testing at the INL’s Materials and Fuels Complex (MFC) can occur starting with shipment of samples from CPP-603 over an on-site road, avoiding the need to use public highways. This reduces cost and reduces the risk to the public. The full suite of characterization methods needed to establish the condition of the fuel exists and MFC. Many other testing capabilities also exist at MFC, but when those capabilities are not adequate, samples can be prepared and shipped to other laboratories for testing. This report discusses how the casks would be handled, what work needs to be done to ready the facilities/capabilities, and what the work will cost.« less

  7. Region-specific ischemia, neovascularization and macular oedema in treatment-naïve proliferative diabetic retinopathy.

    PubMed

    Lange, Jason; Hadziahmetovic, Majda; Zhang, Jingfa; Li, Weiye

    2018-02-07

    Region-specific pathology in proliferative diabetic retinopathy enhances our understanding and management of this disease. To investigate non-perfusion, neovascularization and macular oedema. A cross-sectional, observational, non-randomized study. Consecutive 43 eyes of 27 treatment-naïve patients. Ultra-widefield fluorescein angiography for studying specific zones, that is, far-peripheral zone, mid-peripheral zone and central retina (cr), and spectral-domain optical coherence tomography for analysing thickness of macular layers. Non-perfusion index (NPI) and neovascularization index (NVI) in different zones, thickness of cr, retinal nerve fibre layer, ganglion cell layer (GCL), inner nuclear layer (INL) and outer plexiform layer in parafoveal regions. The NPI of far-periphery and NVI of mid-periphery were the highest by one-way analysis of variance testing. Ischemic retina defined as high NPI in far-periphery was significantly related to macular oedema via a binary classification approach (P < 0.05). The ischemic retina was correlated with a decreased thickness of both retinal nerve fibre and GCL (P < 0.05); macular oedema was correlated with increased INL thickness (P < 0.0001). The region-specific correlation of NPI of far-periphery and NVI of mid-periphery, but not with central retinal thickness, suggests different pathogeneses of neovascularization and macular oedema. Retinal nerve fibre layer and GCL, both biomarkers of diabetic retinal neuronopathy, are associated with retinal ischemia, but not with macular oedema, suggesting that diabetic microangiopathy and neuronopathy possess distinct pathogenic pathways. The strong correlation between macular oedema and INL indicates that intracellular oedema is a determining factor of diabetic macular oedema. © 2018 Royal Australian and New Zealand College of Ophthalmologists.

  8. Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons

    NASA Astrophysics Data System (ADS)

    Flores, Thomas; Lei, Xin; Huang, Tiffany; Lorach, Henri; Dalal, Roopa; Galambos, Ludwig; Kamins, Theodore; Mathieson, Keith; Palanker, Daniel

    2018-06-01

    Objective. High-resolution prosthetic vision requires dense stimulating arrays with small electrodes. However, such miniaturization reduces electrode capacitance and penetration of electric field into tissue. We evaluate potential solutions to these problems with subretinal implants based on utilization of pillar electrodes. Approach. To study integration of three-dimensional (3D) implants with retinal tissue, we fabricated arrays with varying pillar diameter, pitch, and height, and implanted beneath the degenerate retina in rats (Royal College of Surgeons, RCS). Tissue integration was evaluated six weeks post-op using histology and whole-mount confocal fluorescence imaging. The electric field generated by various electrode configurations was calculated in COMSOL, and stimulation thresholds assessed using a model of network-mediated retinal response. Main results. Retinal tissue migrated into the space between pillars with no visible gliosis in 90% of implanted arrays. Pillars with 10 μm height reached the middle of the inner nuclear layer (INL), while 22 μm pillars reached the upper portion of the INL. Electroplated pillars with dome-shaped caps increase the active electrode surface area. Selective deposition of sputtered iridium oxide onto the cap ensures localization of the current injection to the pillar top, obviating the need to insulate the pillar sidewall. According to computational model, pillars having a cathodic return electrode above the INL and active anodic ring electrode at the surface of the implant would enable six times lower stimulation threshold, compared to planar arrays with circumferential return, but suffer from greater cross-talk between the neighboring pixels. Significance. 3D electrodes in subretinal prostheses help reduce electrode-tissue separation and decrease stimulation thresholds to enable smaller pixels, and thereby improve visual acuity of prosthetic vision.

  9. Lessons Learned about Plug-in Electric Vehicle Charging Infrastructure from The EV Project and ChargePoint America

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smart, John Galloway; Salisbury, Shawn Douglas

    2015-07-01

    This report summarizes key findings in two national plug-in electric vehicle charging infrastructure demonstrations: The EV Project and ChargePoint America. It will be published to the INL/AVTA website for the general public.

  10. ETRMTR MECHANICAL SERVICES BUILDING, TRA653. CAMERA FACING NORTHWEST AS BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR-MTR MECHANICAL SERVICES BUILDING, TRA-653. CAMERA FACING NORTHWEST AS BUILDING WAS NEARLY COMPLETE. INL NEGATIVE NO. 57-3653. K. Mansfield, Photographer, 7/22/1957 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  11. SOUTH, EAST, NORTH ELEVATIONS AND SECTIONS OF FUEL STORAGE BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH, EAST, NORTH ELEVATIONS AND SECTIONS OF FUEL STORAGE BUILDING (CPP-603). INL DRAWING NUMBER 200-0603-61-299-103030. ALTERNATE ID NUMBER 542-31-B-22. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  12. INTERIOR OF SECOND FLOOR CONTROL ROOM OF FUEL STORAGE BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR OF SECOND FLOOR CONTROL ROOM OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING SOUTHWEST. INL PHOTO NUMBER HD-54-19-2. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  13. NORTHERN PORTION OF WEST ELEVATION OF FUEL STORAGE BUILDING (CPP603). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTHERN PORTION OF WEST ELEVATION OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING NORTHEAST. INL PHOTO NUMBER HD-54-20-4. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  14. EAST WEST NORTH ELEVATIONS OF MULTICURIE CELL ARCHITECTURAL DETAILS REMOTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EAST WEST NORTH ELEVATIONS OF MULTICURIE CELL ARCHITECTURAL DETAILS REMOTE ANALYTICAL FACILITY (CPP-627). INL DRAWING NUMBER 200-00627-00-706-050245. ALTERNATE ID NUMBER AED-D-245. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  15. ARCHITECTURAL FLOOR PLAN OF OPERATING AREA HOT PILOT PLANT (CPP640). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARCHITECTURAL FLOOR PLAN OF OPERATING AREA HOT PILOT PLANT (CPP-640). INL DRAWING NUMBER 200-0640-00-279-111678. ALTERNATE ID NUMBER 8952-CPP-640-A-1. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  16. OBLIQUE PHOTO OF NORTHWEST CORNER OF FUEL STORAGE BUILDING (CPP603). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    OBLIQUE PHOTO OF NORTHWEST CORNER OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING SOUTHEAST. INL PHOTO NUMBER HD-54-14-4. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  17. NORTHERN PORTION OF WEST ELEVATION OF FUEL STORAGE BUILDING (CPP603). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTHERN PORTION OF WEST ELEVATION OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING SOUTHEAST. INL PHOTO NUMBER HD-54-20-2. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  18. VIEW OF FECF HOT CELL OF FUEL STORAGE BUILDING (CPP603). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF FECF HOT CELL OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING NORHTWEST. INL PHOTO NUMBER HD-54-18-3. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  19. CONSTRUCTION PROGRESS PHOTO REMOTE ANALYTICAL FACILITY (CPP627) SHOWING EMPLACEMENT OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO REMOTE ANALYTICAL FACILITY (CPP-627) SHOWING EMPLACEMENT OF ROOF SLABS. INL PHOTO NUMBER NRTS-54-13463. R.G. Larsen, Photographer, 12/20/1954 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  20. VIEW OF TRANSFER BASIN CORRIDOR OF FUEL STORAGE BUILDING (CPP603). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF TRANSFER BASIN CORRIDOR OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING NORTH. INL PHOTO NUMBER HD-54-17-2. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  1. PLAN SECTIONS AND DETAILS OF CELL HATCHES MAIN PROCESSING BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PLAN SECTIONS AND DETAILS OF CELL HATCHES MAIN PROCESSING BUILDING (CPP-601). INL DRAWING NUMBER 200-0601-00-291-103256. ALTERNATE ID NUMBER 542-11-F-302. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  2. OBLIQUE PHOTO OF NORTH ELEVATION OF FUEL STORAGE BUILDING (CPP603). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    OBLIQUE PHOTO OF NORTH ELEVATION OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING SOUTH. INL PHOTO NUMBER HD-54-14-3. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  3. ARCHITECTURAL DOOR DETAILS AND SCHEDULE OF HOT PILOT PLANT (CPP640). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARCHITECTURAL DOOR DETAILS AND SCHEDULE OF HOT PILOT PLANT (CPP-640). INL DRAWING NUMBER 200-640-00-279-111683. ALTERNATE ID NUMBER 8952-CPP-640-A-6. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  4. ARCHITECTURAL SECTIONS A, B, C, D, OF HOT PILOT PLANT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARCHITECTURAL SECTIONS A, B, C, D, OF HOT PILOT PLANT (CPP-640). INL DRAWING NUMBER 200-0640-00-279-111681. ALTERNATE ID NUMBER 8952-CPP-640-A-5. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  5. FAST CHOPPER BUILDING, TRA665. DETAIL OF STEEL DOOR ENTRY TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FAST CHOPPER BUILDING, TRA-665. DETAIL OF STEEL DOOR ENTRY TO LOWER LEVEL. CAMERA FACING NORTH. INL NEGATIVE NO. HD42-1. Mike Crane, Photographer, 3/2004 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  6. Transmission Line Security Monitor

    ScienceCinema

    None

    2017-12-09

    The Transmission Line Security Monitor is a multi-sensor monitor that mounts directly on high-voltage transmission lines to detect, characterize and communicate terrorist activity, human tampering and threatening conditions around support towers. For more information about INL's critical infrastructure protection research, visit http://www.facebook.com/idahonationallaboratory.

  7. Usage of Electric Vehicle Supply Equipment Along the Corridors between the EV Project Major Cities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mindy Kirkpatrick

    The report explains how the EVSE are being used along the corridors between the EV Project cities. The EV Project consists of a nationwide collaboration between Idaho National Laboratory (INL), ECOtality North America, Nissan, General Motors, and more than 40 other city, regional and state governments, and electric utilities. The purpose of the EV Project is to demonstrate the deployment and use of approximately 14,000 Level II (208-240V) electric vehicle supply equipment (EVSE) and 300 fast chargers in 16 major cities. This research investigates the usage of all currently installed EV Project commercial EVSE along major interstate corridors. ESRI ArcMapmore » software products are utilized to create geographic EVSE data layers for analysis and visualization of commercial EVSE usage. This research locates the crucial interstate corridors lacking sufficient commercial EVSE and targets locations for future commercial EVSE placement. The results and methods introduced in this research will be used by INL for the duration of the EV Project.« less

  8. Intelligent unmanned vehicle systems suitable for individual or cooperative missions

    NASA Astrophysics Data System (ADS)

    Anderson, Matthew O.; McKay, Mark D.; Wadsworth, Derek C.

    2007-04-01

    The Department of Energy's Idaho National Laboratory (INL) has been researching autonomous unmanned vehicle systems for over fifteen years. Areas of research have included unmanned ground and aerial vehicles used for hazardous and remote operations as well as teamed together for advanced payloads and mission execution. Areas of application include aerial particulate sampling, cooperative remote radiological sampling, and persistent surveillance including real-time mosaic and geo-referenced imagery in addition to high-resolution still imagery. Both fixed-wing and rotary airframes are used possessing capabilities spanning remote control to fully autonomous operation. Patented INL-developed auto steering technology is taken advantage of to provide autonomous parallel path swathing with either manned or unmanned ground vehicles. Aerial look-ahead imagery is utilized to provide a common operating picture for the ground and air vehicles during cooperative missions. This paper will discuss the various robotic vehicles, including sensor integration, used to achieve these missions and anticipated cost and labor savings.

  9. Reducing Risk for the Next Generation Nuclear Plant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    John M. Beck II; Harold J. Heydt; Emmanuel O. Opare

    2010-07-01

    The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project.more » Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.« less

  10. The effect of a hyperdynamic environment on the development of the rat retina

    NASA Technical Reports Server (NTRS)

    Murakami, D. M.; Fuller, C. A.

    1985-01-01

    The effects of a 2 G field on the retinal development of the layers in the rat and central visual system nuclei are investigated. The thickness of the retinal layers, ganglion cells, and brains of male and female Wistar rats suspended from an 18 foot diameter centrifuge creating a 2 G field are evaluated and compared with a control group. A decrease in the thickness of the outer nuclear layer (ONL) of 37.1 percent, of 58.5 percent in the inner nuclear layer (INL), and of 28.8 percent in the inner plexiform layer (IPL), and a reduction in body weight are observed in the 2-G rats. The data reveal that the ganglion cells and visual system nuclei activity correspond well with the control data; however, the medial terminal nucleus (MTN) activity is inhibited in the 2-G rats. It is concluded that the differences in ONL and IPL are attributed to body weight reduction, but the INL and MTN are affected by the 2-G conditions.

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Layton, Deborah L.

    The Toxic Substances Control Act, 40 CFR 761.65(a)(1) provides an exemption from the one year storage time limit for PCB/radioactive waste. PCB/radioactive waste may exceed the one year time limit provided that the provisions at 40 CFR 761.65(a)(2)(ii) and 40 CFR 761.65(a)(2)(iii) are followed. These two subsections require, (ii) "A written record documenting all continuing attempts to secure disposal is maintained until the waste is disposed of" and (iii) "The written record required by subsection (ii) of this section is available for inspection or submission if requested by EPA." EPA Region 10 has requested the Department of Energy (DOE) tomore » submit an inventory of radioactive-contaminated PCB waste in storage at the Idaho National Laboratory (INL) for the previous calendar year. The annual inventory is separated into two parts, INL without Advanced Mixed Waste Treatment Project (AMWTP) (this includes Battelle Energy Alliance, LLC, CH2M-WG Idaho, LLC, and the Naval Reactors Facility), and AMWTP.« less

  12. Isolation and Purification of the Xenon Fraction of 252Cf Spontaneous Fission Products for the Production of Radio Xenon Calibration Standards

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McGrath, Christopher A.

    2015-04-01

    The presence of radioactive xenon isotopes indicates that fission events have occurred, and is used to help enforce the Comprehensive Test Ban Treaty. Idaho National Laboratory (INL) produces 135Xe, 133mXe, 133Xe, and 131mXe standards used for the calibration and testing of collection equipment and analytical techniques used to monitor radio xenon emissions. At INL, xenon is produced and collected as one of several spontaneous fission products from a 252Cf source. Further chromatographic purification of the fission gases ensures the separations of the xenon fraction for selective collection. An explanation of the fission gas collection, separation and purification is presented. Additionally,more » the range of 135Xe to 133Xe ratio that can be isolated is explained. This is an operational update on the work introduced previously, now that it is in operation and has been recharged with a second 252Cf source.« less

  13. Borehole deviation and correction factor data for selected wells in the eastern Snake River Plain aquifer at and near the Idaho National Laboratory, Idaho

    USGS Publications Warehouse

    Twining, Brian V.

    2016-11-29

    The U.S. Geological Survey (USGS), in cooperation with the U.S. Department of Energy, has maintained a water-level monitoring program at the Idaho National Laboratory (INL) since 1949. The purpose of the program is to systematically measure and report water-level data to assess the eastern Snake River Plain aquifer and long term changes in groundwater recharge, discharge, movement, and storage. Water-level data are commonly used to generate potentiometric maps and used to infer increases and (or) decreases in the regional groundwater system. Well deviation is one component of water-level data that is often overlooked and is the result of the well construction and the well not being plumb. Depending on measured slant angle, where well deviation generally increases linearly with increasing slant angle, well deviation can suggest artificial anomalies in the water table. To remove the effects of well deviation, the USGS INL Project Office applies a correction factor to water-level data when a well deviation survey indicates a change in the reference elevation of greater than or equal to 0.2 ft.Borehole well deviation survey data were considered for 177 wells completed within the eastern Snake River Plain aquifer, but not all wells had deviation survey data available. As of 2016, USGS INL Project Office database includes: 57 wells with gyroscopic survey data; 100 wells with magnetic deviation survey data; 11 wells with erroneous gyroscopic data that were excluded; and, 68 wells with no deviation survey data available. Of the 57 wells with gyroscopic deviation surveys, correction factors for 16 wells ranged from 0.20 to 6.07 ft and inclination angles (SANG) ranged from 1.6 to 16.0 degrees. Of the 100 wells with magnetic deviation surveys, a correction factor for 21 wells ranged from 0.20 to 5.78 ft and SANG ranged from 1.0 to 13.8 degrees, not including the wells that did not meet the correction factor criteria of greater than or equal to 0.20 ft.Forty-seven wells had gyroscopic and magnetic deviation survey data for the same well. Datasets for both survey types were compared for the same well to determine whether magnetic survey data were consistent with gyroscopic survey data. Of those 47 wells, 96 percent showed similar correction factor estimates (≤ 0.20 ft) for both magnetic and gyroscopic well deviation surveys. A linear comparison of correction factor estimates for both magnetic and gyroscopic deviation well surveys for all 47 wells indicate good linear correlation, represented by an r-squared of 0.88. The correction factor difference between the gyroscopic and magnetic surveys for 45 of 47 wells ranged from 0.00 to 0.18 ft, not including USGS 57 and USGS 125. Wells USGS 57 and USGS 125 show a correction factor difference of 2.16 and 0.36 ft, respectively; however, review of the data files suggest erroneous SANG data for both magnetic deviation well surveys. The difference in magnetic and gyroscopic well deviation SANG measurements, for all wells, ranged from 0.0 to 0.9 degrees. These data indicate good agreement between SANG data measured using the magnetic deviation survey methods and SANG data measured using gyroscopic deviation survey methods, even for surveys collected years apart.

  14. Experimental design, operation, and results of a 4 kW high temperature steam electrolysis experiment

    DOE PAGES

    Zhang, Xiaoyu; O'Brien, James E.; Tao, Greg; ...

    2015-08-06

    High temperature steam electrolysis (HTSE) is a promising technology for large-scale hydrogen production. However, research on HTSE performance above the kW level is limited. This paper presents the results of 4 kW HTSE long-term test completed in a multi-kW test facility recently developed at the Idaho National Laboratory (INL). The 4 kW HTSE unit included two solid oxide electrolysis stacks operating in parallel, each of which included 40 electrode-supported planar cells. A current density of 0.41 A/cm2 was used for the long-term operation, resulting in a hydrogen production rate about 25 slpm. A demonstration of 920 hours stable operation wasmore » achieved. The paper also includes detailed descriptions of the piping layout, steam generation and delivery system, test fixture, heat recuperation system, hot zone, instrumentation, and operating conditions. As a result, this successful demonstration of multi-kW scale HTSE unit will help to advance the technology toward near-term commercialization.« less

  15. Produced Water Treatment Using the Switchable Polarity Solvent Forward Osmosis (SPS FO) Desalination Process: Preliminary Engineering Design Basis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wendt, Daniel; Adhikari, Birendra; Orme, Christopher

    Switchable Polarity Solvent Forward Osmosis (SPS FO) is a semi-permeable membrane-based water treatment technology. INL is currently advancing SPS FO technology such that a prototype unit can be designed and demonstrated for the purification of produced water from oil and gas production operations. The SPS FO prototype unit will used the thermal energy in the produced water as a source of process heat, thereby reducing the external process energy demands. Treatment of the produced water stream will reduce the volume of saline wastewater requiring disposal via injection, an activity that is correlated with undesirable seismic events, as well as generatemore » a purified product water stream with potential beneficial uses. This paper summarizes experimental data that has been collected in support of the SPS FO scale-up effort, and describes how this data will be used in the sizing of SPS FO process equipment. An estimate of produced water treatment costs using the SPS FO process is also provided.« less

  16. SAFETY AND SECURITY BUILDING, TRA614. ELEVATIONS. SECTIONS. TWO ROOF LEVELS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SAFETY AND SECURITY BUILDING, TRA-614. ELEVATIONS. SECTIONS. TWO ROOF LEVELS. BLAW-KNOX 3150-814-2, 3/1950. INL INDEX NO. 531-0614-00-098-100703, REV. 6. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  17. SAFETY AND SECURITY BUILDING, TRA614. SIMPLIFIED FLOOR LAYOUT AND WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SAFETY AND SECURITY BUILDING, TRA-614. SIMPLIFIED FLOOR LAYOUT AND WEST ELEVATION. BLAW-KNOX 3150-14-1, 1/1950. INL INDEX NO. 531-0614-00-098-100024, REV. 2. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  18. PROCESS WATER BUILDING, TRA605. FLASH EVAPORATOR, CONDENSER (PROJECT FROM EVAPORATOR), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PROCESS WATER BUILDING, TRA-605. FLASH EVAPORATOR, CONDENSER (PROJECT FROM EVAPORATOR), AND STEAM EJECTOR (ALONG REAR WALL). INL NEGATIVE NO. 4377. M.H. Bartz, Photographer, 3/5/1952 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  19. WEST ELEVATION OF REMOTE ANALYTICAL FACILITY (CPP627) AND HOT PILOT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    WEST ELEVATION OF REMOTE ANALYTICAL FACILITY (CPP-627) AND HOT PILOT PLANT (CPP-640) LOOKING NORTHEAST. INL PHOTO NUMBER HD-22-2-1. Mike Crane, Photographer, 11/1998 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  20. VIEW OF CRANE LOADING AND UNLOADING AREA OF FUEL STORAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF CRANE LOADING AND UNLOADING AREA OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING NORTH. INL PHOTO NUMBER HD-54-17-4. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  1. ARCHITECTURAL FLOOR PLAN OF PROCESS AND ACCESS AREAS HOT PILOT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARCHITECTURAL FLOOR PLAN OF PROCESS AND ACCESS AREAS HOT PILOT PLANT (CPP-640). INL DRAWING NUMBER 200-0640-00-279-111679. ALTERNATE ID NUMBER 8952-CPP-640-A-2. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  2. FACILITY LAYOUT OF FUEL STORAGE BUILDING (CPP603) SHOWING STORAGE BASINS, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FACILITY LAYOUT OF FUEL STORAGE BUILDING (CPP-603) SHOWING STORAGE BASINS, FUEL ELEMENT CUTTING FACILITY, AND DRY GRAPHITE STORAGE FACILITY. INL DRAWING NUMBER 200-0603-00-030-056329. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  3. 0BLIQUE PHOTO OF EAST ELEVATION OF FUEL STORAGE BUILDING (CPP603). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    0BLIQUE PHOTO OF EAST ELEVATION OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING WEST. INL PHOTO NUMBER HD-54-15-1. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  4. CONSTRUCTION PROGRESS PHOTO OF HOT PILOT PLANT (CPP640) OVERALL VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION PROGRESS PHOTO OF HOT PILOT PLANT (CPP-640) OVERALL VIEW LOOKING SOUTHEAST; CONSTRUCTION 34 PERCENT COMPLETE. INL PHOTO NUMBER NRTS-60-3034. Holmes, Photographer, 6/23/1960 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  5. VIEW OF CRANE LOADING AND UNLOADING AREA OF FUEL STORAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF CRANE LOADING AND UNLOADING AREA OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING SOUTH. INL PHOTO NUMBER HD-54-17-1. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  6. CONSTRUCTION VIEW OF MAIN PROCESSING BUILDING (CPP601) ON THE RIGHT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONSTRUCTION VIEW OF MAIN PROCESSING BUILDING (CPP-601) ON THE RIGHT AND LABORATORY (CPP-602) ON THE LEFT. INL PHOTO NUMBER NRTS-51-3373. Unknown Photographer, 9/28/1951 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  7. VIEW OF SOUTH STORAGE BASIN NUMBER 1 OF FUEL STORAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF SOUTH STORAGE BASIN NUMBER 1 OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING NORTHEAST. INL PHOTO NUMBER HD-54-18-4. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  8. VIEW OF MIDDLE STORAGE BASIN NUMBER 2 OF FUEL STORAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF MIDDLE STORAGE BASIN NUMBER 2 OF FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING NORTHEAST. INL PHOTO NUMBER HD-54-17-3. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  9. ARCHITECTURAL ROOF PLAN AND WESTSOUTHEAST ELEVATIONS OF HOT PILOT PLANT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARCHITECTURAL ROOF PLAN AND WEST-SOUTHEAST ELEVATIONS OF HOT PILOT PLANT (CPP-640). INL DRAWING NUMBER 200-0640-00-279-111680. ALTERNATE ID NUMBER 8952-CPP-640-A-3. - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  10. FAN HOUSE INTERIOR. THREE MOTOR DRIVES FOR POSITIVE DISPLACEMENT BLOWERS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FAN HOUSE INTERIOR. THREE MOTOR DRIVES FOR POSITIVE DISPLACEMENT BLOWERS LINE UP ON NORTH WALL. CONCRETE PEDESTALS. CAMERA FACES NORTHEAST. INL NEGATIVE NO. 4291. Unknown Photographer, 2/26/1952 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  11. MTR BUILDING AND BALCONY FLOORS. CAMERA FACING EASTERLY. PHOTOGRAPHER DID ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR BUILDING AND BALCONY FLOORS. CAMERA FACING EASTERLY. PHOTOGRAPHER DID NOT EXPLAIN DARK CLOUD. MTR WING WILL ATTACH TO GROUND FLOOR. INL NEGATIVE NO. 1567. Unknown Photographer, 2/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  12. Motion-to-Energy (M2Eâ„¢) Power Generation Technology

    ScienceCinema

    Idaho National Laboratory

    2017-12-09

    INL researchers developed M2E, a new technology that converts motion to energy. M2E uses an innovative, optimized microgenerator with power management circuitry that kinetically charges mobile batteries from natural motion such as walking. To learn more,

  13. ETR BUILDING, TRA642, INTERIOR. BASEMENT. LIQUID SODIUM PIPING INSIDE CUBICLE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR BUILDING, TRA-642, INTERIOR. BASEMENT. LIQUID SODIUM PIPING INSIDE CUBICLE SHOWN IN ID-33-G-101. INL NEGATIVE NO. HD24-3-4. Mike Crane, Photographer, 11/2000 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  14. SOUTH ELEVATION OF IRRADIATED FUEL STORAGE FACILITY LOCATED IN FUEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTH ELEVATION OF IRRADIATED FUEL STORAGE FACILITY LOCATED IN FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING NORTH. INL PHOTO NUMBER HD-54-15-2. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  15. NORTH ELEVATION OF IRRADIATED FUEL STORAGE FACILITY LOCATED IN FUEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTH ELEVATION OF IRRADIATED FUEL STORAGE FACILITY LOCATED IN FUEL STORAGE BUILDING (CPP-603). PHOTO TAKEN LOOKING SOUTH. INL PHOTO NUMBER HD-54-16-1. Mike Crane, Photographer, 8/2005 - Idaho National Engineering Laboratory, Idaho Chemical Processing Plant, Fuel Reprocessing Complex, Scoville, Butte County, ID

  16. Retinal neurodegeneration in patients with type 1 diabetes mellitus: the role of glycemic variability.

    PubMed

    Picconi, Fabiana; Parravano, Mariacristina; Ylli, Dorina; Pasqualetti, Patrizio; Coluzzi, Sara; Giordani, Ilaria; Malandrucco, Ilaria; Lauro, Davide; Scarinci, Fabio; Giorno, Paola; Varano, Monica; Frontoni, Simona

    2017-05-01

    Recent studies have identified neuroretinal abnormalities in persons affected by diabetes mellitus, before the onset of microvascular alterations. However, the role of glycemic variability (GV) on early retinal neurodegeneration is still not clarified. To explore the relationship between glycemic control and neuroretinal characteristics, 37 persons with Type 1 diabetes mellitus (Type 1 DM) divided into two groups with no signs (noRD) and with mild non-proliferative diabetic retinopathy (NPDR) compared to 13 healthy control participants (C) were recruited. All persons underwent an optical coherence tomography with automatic segmentation of all neuroretinal layers. Measurements of mean of nasal (N)/temporal (T)/superior (S)/inferior (I) macular quadrants for individual layer were also calculated. Metabolic control was evaluated by glycated hemoglobin (HbA1c), and indexes of GV were calculated from continuous glucose monitoring. The difference among the three groups in terms of RNFL thickness was significantly dependent on quadrant (F(6;132) = 2.315; p = 0.037). This interaction was due to a specific difference in RNFL-N thickness, where both Type 1 DM groups showed a similar reduction versus C (-3.9 for noDR and -4.9 for NPDR), without any relevant difference between them (-1.0). Inner nuclear layer (INL) was increased in all quadrants in the two Type 1 DM groups compared to C (mean difference = 7.73; 95% CI: 0.32-15.14, p = 0.043; mean difference = 7.74; 95% CI: 0.33-15.15, p = 0.043, respectively). A negative correlation between RNFL-N and low blood glucose index (r = -0.382, p = 0.034) and positive correlation between INL and continuous overall net glycemic action -1, -2, -4 h (r = 0.40, p = 0.025; r = 0.39, p = 0.031; r = 0.41, p = 0.021, respectively) were observed in Type 1 DM patients. The triglycerides were positively and significantly correlated to INL (r = 0.48, p = 0.011), in Type 1 DM subjects. GV and triglycerides resulted both independent predictors of increased INL thickness. No correlation was found with HbA1c. Early structural damage of neuroretina in persons with Type 1 DM patients is related to glucose fluctuations. GV should be addressed, even in the presence of a good metabolic control.

  17. Listeria monocytogenes Prevalence and Characteristics in Retail Raw Foods in China

    PubMed Central

    Wu, Shi; Wu, Qingping; Zhang, Jumei; Chen, Moutong; Yan, Ze′an; Hu, Huijuan

    2015-01-01

    The prevalence and levels of Listeria monocytogenes in retail raw foods covering most provincial capitals in China were studied with testing of 1036 samples of vegetables, edible mushrooms, raw meat, aquatic products and quick-frozen products from September 2012 to January 2014. The total prevalence of Listeria monocytogenes was 20.0% (207/1036), and the most probable number (MPN) values of 65.7% of the positive samples ranged from 0.3 to 110 MPN/g. Geographical differences were observed in this survey, and the results of both qualitative and quantitative methods indicated that the levels in the samples from North China were higher than those in the samples from South China. A total of 248 isolates were analyzed, of which approximately half belonged to molecular serogroup 1/2a-3a (45.2%), followed by 1/2b-3b-7 (30.6%), 1/2c-3c (16.1%), 4b-4d-4e (5.2%) and 4a-4c (2.8%). Most of the isolates carried hly (100%), inlB (98.8%), inlA (99.6%), inlC (98.0%) and inlJ (99.2%), and 44.8% of the isolates were llsX-positive. Seventeen epidemic clones (ECs) were detected, with 7 strains belonging to ECI (2.8%) and 10 belonging to ECIII (4.03%). Resistance to clindamycin (46.8%) was commonly observed, and 59 strains (23.8%) were susceptible to all 14 tested antibiotics, whereas 84 (33.9%) showed an intermediate level of resistance or were resistant to two or more antibiotics, including 7 multi-resistant strains that exhibited resistance to more than 10 antibiotics. The data obtained in the present study provides useful information for assessment of the possible risk posed to Chinese consumers, and this information will have a significant public health impact in China. Furthermore, the presence of virulence markers, epidemic clones, as well as the antibiotic resistance amongst the isolates strongly implies that many of these strains might be capable of causing listeriosis, and more accurate treatment of human listeriosis with effective antibiotics should be considered. This research represents a more full-scale and systematical investigation of the prevalence of L. monocytogenes in retail raw foods in China, and it provides baseline information for Chinese regulatory authorities that will aid in the formulation of a regulatory framework for controlling L. monocytogenes with the aim of improving the microbiological safety of raw foods. PMID:26317852

  18. Status Report on Efforts to Enhance Instrumentation to Support Advanced Test Reactor Irradiations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    J. Rempe; D. Knudson; J. Daw

    2014-01-01

    The Department of Energy (DOE) designated the Advanced Test Reactor (ATR) as a National Scientific User Facility (NSUF) in April 2007 to support the growth of nuclear science and technology in the United States (US). By attracting new research users - universities, laboratories, and industry - the ATR NSUF facilitates basic and applied nuclear research and development, further advancing the nation's energy security needs. A key component of the ATR NSUF effort at the Idaho National Laboratory (INL) is to design, develop, and deploy new in-pile instrumentation techniques that are capable of providing real-time measurements of key parameters during irradiation.more » To address this need, an assessment of instrumentation available and under-development at other test reactors was completed. Based on this initial review, recommendations were made with respect to what instrumentation is needed at the ATR, and a strategy was developed for obtaining these sensors. In 2009, a report was issued documenting this program’s strategy and initial progress toward accomplishing program objectives. Since 2009, annual reports have been issued to provide updates on the program strategy and the progress made on implementing the strategy. This report provides an update reflecting progress as of January 2014.« less

  19. ETR ELECTRICAL BUILDING, TRA648. EMERGENCY STANDBY GENERATOR AND DIESEL UNIT. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR ELECTRICAL BUILDING, TRA-648. EMERGENCY STANDBY GENERATOR AND DIESEL UNIT. METAL ROOF AND PUMICE BLOCK WALLS. CAMERA FACING SOUTHWEST. INL NEGATIVE NO. 56-3708. R.G. Larsen, Photographer, 11/13/1956 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  20. ETR ELECTRICAL BUILDING, TRA648. FLOOR PLANS FOR FIRST FLOOR AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ETR ELECTRICAL BUILDING, TRA-648. FLOOR PLANS FOR FIRST FLOOR AND BASEMENT. SECTIONS. KAISER ETR-5528-MTR-648-A-2, 12/1955. INL INDEX NO. 532-0648-00-486-101402, REV. 6. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

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