Science.gov

Sample records for innovative systems systeme

  1. Innovating blackberry production system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This article provides an overview of progress made on the blackberry production system at the Appalachian Fruit Research Station in Kearneysville, WV. Several lines of research have made a significant positive impact to the blackberry industry as the new technology has have been successfully transf...

  2. A Profile of Innovative School Systems.

    ERIC Educational Resources Information Center

    Hilfiker, Leo R.

    An earlier report examined the relationship of school system innovativeness to selected dimensions of interpersonal behavior in eight school systems as revealed through data collected in 1967. The major implication of this study suggested that the climate of the schools might be changed to make them more receptive to innovation from within or from…

  3. Comparing Three Innovative Instructional Systems.

    ERIC Educational Resources Information Center

    Dunn, Rita; Waggoner, Barbara

    1995-01-01

    Examines the differences between three instructional systems: learning styles, neuro-linguistic programming, and "Suggestopoedia." Topics include the philosophical basis of each system; teaching methodologies; the use of multimedia; the use of time; environmental settings; and approaches to human emotion, individual sociological differences, and…

  4. Systems Innovation and Education Management Systems (EMS)

    ERIC Educational Resources Information Center

    Rao, Nageswararao A. V.

    2006-01-01

    Many researchers and practitioners contend that all institutions respond to changing market need and can create competitive advantage through innovation and creativity. Each year, institutions expend significant resources developing new products and processes and yet research shows that more than half these initiatives fail. Successful…

  5. Using Innovative Information Systems Techniques To Teach Information Systems.

    ERIC Educational Resources Information Center

    Chimi, Carl J.; Gordon, Gene M.

    This paper discusses a number of innovative techniques that were used to teach courses in Information Systems to undergraduate and graduate students. While none of these techniques is individually innovative, the combination of techniques provides a true "hands-on" environment for students; because of the way that the components of the courses are…

  6. Innovative shotcreting system in Japan

    SciTech Connect

    Okada, Takashi

    1995-12-31

    Robotization of shotcreting has advanced remarkably in Japan in a short span of time for the purpose of avoiding exposure of human workers to adverse conditions. This paper provides an overview of various devices used in shotcreting and discusses the development of improved systems which ensure higher safety and larger productivity.

  7. What Is a Complex Innovation System?

    PubMed Central

    Katz, J. Sylvan

    2016-01-01

    Innovation systems are sometimes referred to as complex systems, something that is intuitively understood but poorly defined. A complex system dynamically evolves in non-linear ways giving it unique properties that distinguish it from other systems. In particular, a common signature of complex systems is scale-invariant emergent properties. A scale-invariant property can be identified because it is solely described by a power law function, f(x) = kxα, where the exponent, α, is a measure of scale-invariance. The focus of this paper is to describe and illustrate that innovation systems have properties of a complex adaptive system. In particular scale-invariant emergent properties indicative of their complex nature that can be quantified and used to inform public policy. The global research system is an example of an innovation system. Peer-reviewed publications containing knowledge are a characteristic output. Citations or references to these articles are an indirect measure of the impact the knowledge has on the research community. Peer-reviewed papers indexed in Scopus and in the Web of Science were used as data sources to produce measures of sizes and impact. These measures are used to illustrate how scale-invariant properties can be identified and quantified. It is demonstrated that the distribution of impact has a reasonable likelihood of being scale-invariant with scaling exponents that tended toward a value of less than 3.0 with the passage of time and decreasing group sizes. Scale-invariant correlations are shown between the evolution of impact and size with time and between field impact and sizes at points in time. The recursive or self-similar nature of scale-invariance suggests that any smaller innovation system within the global research system is likely to be complex with scale-invariant properties too. PMID:27258040

  8. What Is a Complex Innovation System?

    PubMed

    Katz, J Sylvan

    2016-01-01

    Innovation systems are sometimes referred to as complex systems, something that is intuitively understood but poorly defined. A complex system dynamically evolves in non-linear ways giving it unique properties that distinguish it from other systems. In particular, a common signature of complex systems is scale-invariant emergent properties. A scale-invariant property can be identified because it is solely described by a power law function, f(x) = kxα, where the exponent, α, is a measure of scale-invariance. The focus of this paper is to describe and illustrate that innovation systems have properties of a complex adaptive system. In particular scale-invariant emergent properties indicative of their complex nature that can be quantified and used to inform public policy. The global research system is an example of an innovation system. Peer-reviewed publications containing knowledge are a characteristic output. Citations or references to these articles are an indirect measure of the impact the knowledge has on the research community. Peer-reviewed papers indexed in Scopus and in the Web of Science were used as data sources to produce measures of sizes and impact. These measures are used to illustrate how scale-invariant properties can be identified and quantified. It is demonstrated that the distribution of impact has a reasonable likelihood of being scale-invariant with scaling exponents that tended toward a value of less than 3.0 with the passage of time and decreasing group sizes. Scale-invariant correlations are shown between the evolution of impact and size with time and between field impact and sizes at points in time. The recursive or self-similar nature of scale-invariance suggests that any smaller innovation system within the global research system is likely to be complex with scale-invariant properties too.

  9. Organizational innovation and the laboratory information system.

    PubMed

    Friedman, B A; Mitchell, W

    1990-01-01

    There is an urgent need for more innovation in health care and in clinical laboratories. Innovation can be divided into five separate categories: core products, components of the core products, production processes, uses of products, and the organization of production. Organizational innovation is an important as technological advances in increasing the quality and efficiency of clinical laboratories. The use of a laboratory information system (LIS) can stimulate organizational innovation such as the assignment of computer-oriented tasks to personnel within individual clinical laboratories. The authors refer to such LIS support personnel as "hidden personnel" and suggest that such a shift of responsibility empowers laboratory professionals and makes them stakeholders in automated information processing.

  10. Innovative Design of Complex Engineering Systems

    NASA Technical Reports Server (NTRS)

    Noor, Ahmed K. (Compiler)

    2004-01-01

    The document contains the proceedings of the training workshop on Innovative Design of Complex Engineering Systems. The workshop was held at the Peninsula Higher Education Center, Hampton, Virginia, March 23 and 24, 2004. The workshop was jointly sponsored by Old Dominion University and NASA. Workshop attendees came from NASA, other government agencies, industry and universities. The objectives of the workshop were to a) provide broad overviews of the diverse activities related to innovative design of high-tech engineering systems; and b) identify training needs for future aerospace work force development in the design area. The format of the workshop included fifteen, half-hour overview-type presentations, a panel discussion on how to teach and train engineers in innovative design, and three exhibits by commercial vendors.

  11. Enhancing the Reflexivity of System Innovation Projects with System Analyses

    ERIC Educational Resources Information Center

    van Mierlo, Barbara; Arkesteijn, Marlen; Leeuwis, Cees

    2010-01-01

    Networks aiming for fundamental changes bring together a variety of actors who are part and parcel of a problematic context. These system innovation projects need to be accompanied by a monitoring and evaluation approach that supports and maintains reflexivity to be able to deal with uncertainties and conflicts while challenging current practices…

  12. Tomotherapy and other innovative IMRT delivery systems.

    PubMed

    Fenwick, John D; Tomé, Wolfgang A; Soisson, Emilie T; Mehta, Minesh P; Rock Mackie, T

    2006-10-01

    Fixed-field treatments, delivered using conventional clinical linear accelerators fitted with multileaf collimators, have rapidly become the standard form of intensity-modulated radiotherapy (IMRT). Several innovative nonstandard alternatives also exist, for which delivery and treatment planning systems are now commercially available. Three of these nonstandard IMRT approaches are reviewed here: tomotherapy, robotic linear accelerators (CyberKnife, Accuray Inc., Sunnyvale, CA), and standard linear accelerators modulated by jaws alone or by their jaws acting together with a tertiary beam-masking device. Rationales for the nonstandard IMRT approaches are discussed, and elements of their delivery system designs are briefly described. Differences between fixed-field IMRT dose distributions and the distributions that can be delivered by using the nonstandard technologies are outlined. Because conventional linear accelerators are finely honed machines, innovative design enhancement of one aspect of system performance often limits another facet of machine capability. Consequently the various delivery systems may prove optimal for different types of treatment, with specific machine designs excelling for disease sites with specific target volume and normal structure topologies. However it is likely that the delivery systems will be distinguished not just by the optimality of the dose distributions they deliver, but also by factors such as the efficiency of their treatment process, the integration of their onboard imaging systems into that process, and their ability to measure and minimize or compensate for target movement, including the effects of respiratory motion.

  13. The PCAST Energy Technology Innovation System Study

    NASA Astrophysics Data System (ADS)

    Savitz, M.; Fri, R.

    2010-12-01

    The President's Council of Advisors on Science and Technology (PCAST) recently made recommendations for strengthening the nation's energy innovation system. The PCAST report builds in part on earlier work at the National Research Council (NRC) and elsewhere. For example, PCAST largely adopted the description of the energy innovation system that appeared in the NRC report on 'Limiting the Magnitude of Future Climate Change'. Similarly, the 'Limiting' report provided examples of the importance of social science research in crafting energy policy, a recommendation of the PCAST report. And both the 'Limiting' report and an earlier report on 'America's Energy Future' recommended an aggressive commercial demonstration program for carbon capture and storage and new nuclear power plants. The PCAST report discusses the need for new approaches for federal demonstration projects. This session traces these relationships and suggests how similar synergies might be encouraged in the future.

  14. [Innovation and the next generation radiotherapy system].

    PubMed

    Tanabe, Eiji

    2013-01-01

    Innovation is the key to future success for Japan that is slowly falling behind. Industries targeted by the "Abenomics" growth strategy include healthcare and medicine. Since cancer is the leading cause of death in Japan, the development of a system that can detect and treat early stage cancers will be very valuable for patient QOL and reducing health care costs. Although the effectiveness of radiation therapy for treating early stage cancer is widely recognized, there has been no system to treat small, moving tumors with sub millimeter accuracy. A project supported by NEDO develops a "Next-Generation Radiation Therapy System" that uses high energy, narrow X-rays beams that can be accurately pinpointed deep inside the body. Performance testing of a prototype system is currently underway at the National Center for Global Health and Medicine in Tokyo. PMID:24893448

  15. Innovative ventilation system for animal anatomy laboratory

    SciTech Connect

    Lacey, D.R.; Smith, D.C.

    1997-04-01

    A unique ventilation system was designed and built to reduce formaldehyde fumes in the large animal anatomy lab at the Vet Medical Center at Cornell University. The laboratory includes four rooms totaling 5,500 ft{sup 2}. The main room has 2,300 ft{sup 2} and houses the laboratory where up to 60 students dissect as many as 12 horses at a time. Other rooms are a cold storage locker, an animal preparation room and a smaller lab for specialized instruction. The large animal anatomy laboratory has a history of air quality complaints despite a fairly high ventilation rate of over 10 air changes/hour. The horses are embalmed, creating a voluminous source of formaldehyde and phenol vapors. Budget constraints and increasingly stringent exposure limits for formaldehyde presented a great challenge to design a ventilation system that yields acceptable air quality. The design solution included two innovative elements: air-to-air heat recovery, and focused ventilation.

  16. Structural Conditions for Collaboration and Learning in Innovation Networks: Using an Innovation System Performance Lens to Analyse Agricultural Knowledge Systems

    ERIC Educational Resources Information Center

    Hermans, Frans; Klerkx, Laurens; Roep, Dirk

    2015-01-01

    Purpose: We investigate how the structural conditions of eight different European agricultural innovation systems can facilitate or hinder collaboration and social learning in multidisciplinary innovation networks. Methodology: We have adapted the Innovation System Failure Matrix to investigate the main barriers and enablers eight countries…

  17. INNOVATIVE URBAN WET-WEATHER FLOW MANAGEMENT SYSTEMS

    EPA Science Inventory

    This report describes innovative methods to improve wet weather flow (WWF) management systems, that provide drainage services at the same time as decreasing stormwater pollutant discharges, for urban developments of the 21st century. Traditionally, wet-weather collection systems...

  18. Sustainability Analysis of Innovative Transport System

    NASA Astrophysics Data System (ADS)

    Meiere, Ieva; Bazbauers, Gatis

    2011-01-01

    The focus of the research is to develop a new approach to transport solution based on the use of a conveyortype system and to compare the environmental impact of the new system with the existing ones. The new transport system consists of a conveyor driven by an electric motor, with a wind power plant supplying electricity, hydrogen storage and a fuel cell for matching the wind power production with the motor load. The research tasks included the evaluation of the consumption of fossil fuels and the associated environmental impact of existing transport system and a comparison with energy consumption and associated environmental impact of the new system. The energy balance of the conveyor transport system was modelled on an hourly basis by using the EnergyPLAN computer program [1] which allows to analyze a combination of intermittent renewable energy technologies, storage and transport systems. The results show that the existing transport system has greater impact on the environment than the proposed one.

  19. National Implications: Closed Systems Stifle Innovation, Collaboration and Flexibility

    ERIC Educational Resources Information Center

    Cloud, Michelle; Kritsonis, William Allan

    2006-01-01

    Educational leaders must work to establish organizational structures that help schools achieve and sustain their vision. The intent of this article is to briefly examine how closed systems stifle innovation, collaboration and flexibility in schooling. Innovation, collaboration and flexibility are key ingredients for creating successful…

  20. SUBSURFACE VOLATIZATION AND VENTILATION SYSTEM (SVVS) - INNOVATIVE TECHNOLOGY REPORT

    EPA Science Inventory

    This report summarizes the findings associated with a Demonstration Test of Environmental Improvement Technologies’ (EIT) Subsurface Volatilization and Ventilation System (SVVS) process. The technology was evaluated under the EPA Superfund Innovative Technology Evaluation (SITE) ...

  1. Innovations in an Accounting Information Systems Course.

    ERIC Educational Resources Information Center

    Shaoul, Jean

    A new approach to teaching an introductory accounting information systems course is outlined and the potential of this approach for integrating computers into the accounting curriculum at Manchester University (England) is demonstrated. Specifically, the use of a small inventory recording system and database in an accounting information course is…

  2. Fuelling a National Innovation System in Colombia

    ERIC Educational Resources Information Center

    Lucio-Arias, Diana

    2006-01-01

    This presentation of the innovation-driven environment in Colombia derives from important national efforts to gather and store pertinent information. Two large surveys have tested the "innovative behaviour" of Colombian manufacturing firms--the more recent of these was in 2005. Another information source is the Scienti platform, an online effort…

  3. Schooling Redesigned: Towards Innovative Learning Systems

    ERIC Educational Resources Information Center

    Istance, David

    2015-01-01

    What does redesigning schools and schooling through innovation mean in practice? How might it be brought about? These questions have inspired an influential international reflection on "Innovative Learning Environments" (ILE) led by the OECD. This reflection has already resulted in publications on core design principles and frameworks…

  4. Open Innovation, Triple Helix and Regional Innovation Systems: Exploring CATAPULT Centres in the UK

    ERIC Educational Resources Information Center

    Kerry, Christopher; Danson, Michael

    2016-01-01

    Through the lens of UK CATAPULT Centres this conceptual paper presents an examination of the links between open innovation, the Triple Helix model and regional innovation systems. Highlighting the importance of boundary-spanning intermediaries, the combined role of these concepts is explored in detail. A conceptual model is then proposed which…

  5. Integrated nuclear data utilisation system for innovative reactors.

    PubMed

    Yamano, N; Hasegawa, A; Kato, K; Igashira, M

    2005-01-01

    A five-year research and development project on an integrated nuclear data utilisation system was initiated in 2002, for developing innovative nuclear energy systems such as accelerator-driven systems. The integrated nuclear data utilisation system will be constructed as a modular code system, which consists of two sub-systems: the nuclear data search and plotting sub-system, and the nuclear data processing and utilisation sub-system. The system will be operated with a graphical user interface in order to enable easy utilisation through the Internet by both nuclear design engineers and nuclear data evaluators. This paper presents an overview of the integrated nuclear data utilisation system, describes the development of a prototype system to examine the operability of the user interface and discusses specifications of the two sub-systems. PMID:16381697

  6. Integrated nuclear data utilisation system for innovative reactors.

    PubMed

    Yamano, N; Hasegawa, A; Kato, K; Igashira, M

    2005-01-01

    A five-year research and development project on an integrated nuclear data utilisation system was initiated in 2002, for developing innovative nuclear energy systems such as accelerator-driven systems. The integrated nuclear data utilisation system will be constructed as a modular code system, which consists of two sub-systems: the nuclear data search and plotting sub-system, and the nuclear data processing and utilisation sub-system. The system will be operated with a graphical user interface in order to enable easy utilisation through the Internet by both nuclear design engineers and nuclear data evaluators. This paper presents an overview of the integrated nuclear data utilisation system, describes the development of a prototype system to examine the operability of the user interface and discusses specifications of the two sub-systems.

  7. Innovative insulation systems for superconducting fusion magnets

    NASA Astrophysics Data System (ADS)

    Humer, K.; Bittner-Rohrhofer, K.; Fillunger, H.; Maix, R. K.; Prokopec, R.; Weber, H. W.

    2006-03-01

    Glass fibre reinforced plastics (GFRPs) are usually employed as insulating materials for the superconducting coils of large fusion magnets, e.g. of the International Thermonuclear Experimental Reactor (ITER). Both the radiation spectrum and the stresses at the magnet location significantly influence the mechanical behaviour of the magnet insulation and, therefore, impose high demands on the material performance. During the last few decades, advanced epoxy based GFRPs with improved mechanical properties and radiation hardness were introduced into fusion technology. More recently, cyanate ester (CE) matrix systems have become of special interest. In this paper, various magnet insulation systems containing boron-free R-glass fibre reinforcements in commercial and new epoxies as well as in pure CE and CE/epoxy blended matrix systems are presented. All systems were irradiated in a fission reactor at ambient temperature (~340 K) to a fast neutron fluence of 1 × 1022 m-2 (E>0.1 MeV). The mechanical properties were assessed at 77 K in tension as well as in interlaminar shear prior to and after irradiation under static and dynamic conditions.

  8. MOLECULAR BONDING SYSTEM - INNOVATIVE TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    This document presents an evaluation of the Molecular Bonding System (MBS) and its ability to chemically stabilize three metals-contaminated wstes/soils during a SITe demo. The MBS process treated approximately 500 tons each of soil/Fill, Slag, and Miscellaneous Smelter Waste wit...

  9. Research in Modeling and Simulation for Airspace Systems Innovation

    NASA Technical Reports Server (NTRS)

    Ballin, Mark G.; Kimmel, William M.; Welch, Sharon S.

    2007-01-01

    This viewgraph presentation provides an overview of some of the applied research and simulation methodologies at the NASA Langley Research Center that support aerospace systems innovation. Risk assessment methodologies, complex systems design and analysis methodologies, and aer ospace operations simulations are described. Potential areas for future research and collaboration using interactive and distributed simula tions are also proposed.

  10. Politics of innovation in multi-level water governance systems

    NASA Astrophysics Data System (ADS)

    Daniell, Katherine A.; Coombes, Peter J.; White, Ian

    2014-11-01

    Innovations are being proposed in many countries in order to support change towards more sustainable and water secure futures. However, the extent to which they can be implemented is subject to complex politics and powerful coalitions across multi-level governance systems and scales of interest. Exactly how innovation uptake can be best facilitated or blocked in these complex systems is thus a matter of important practical and research interest in water cycle management. From intervention research studies in Australia, China and Bulgaria, this paper seeks to describe and analyse the behind-the-scenes struggles and coalition-building that occurs between water utility providers, private companies, experts, communities and all levels of government in an effort to support or block specific innovations. The research findings suggest that in order to ensure successful passage of the proposed innovations, champions for it are required from at least two administrative levels, including one with innovation implementation capacity, as part of a larger supportive coalition. Higher governance levels can play an important enabling role in facilitating the passage of certain types of innovations that may be in competition with currently entrenched systems of water management. Due to a range of natural biases, experts on certain innovations and disciplines may form part of supporting or blocking coalitions but their evaluations of worth for water system sustainability and security are likely to be subject to competing claims based on different values and expertise, so may not necessarily be of use in resolving questions of "best courses of action". This remains a political values-based decision to be negotiated through the receiving multi-level water governance system.

  11. Innovative technology summary report: Transportable vitrification system

    SciTech Connect

    1998-09-01

    At the end of the cold war, many of the Department of Energy`s (DOE`s) major nuclear weapons facilities refocused their efforts on finding technically sound, economic, regulatory compliant, and stakeholder acceptable treatment solutions for the legacy of mixed wastes they had produced. In particular, an advanced stabilization process that could effectively treat the large volumes of settling pond and treatment sludges was needed. Based on this need, DOE and its contractors initiated in 1993 the EM-50 sponsored development effort required to produce a deployable mixed waste vitrification system. As a consequence, the Transportable Vitrification System (TVS) effort was undertaken with the primary requirement to develop and demonstrate the technology and associated facility to effectively vitrify, for compliant disposal, the applicable mixed waste sludges and solids across the various DOE complex sites. After 4 years of development testing with both crucible and pilot-scale melters, the TVS facility was constructed by Envitco, evaluated and demonstrated with surrogates, and then successfully transported to the ORNL ETTP site and demonstrated with actual mixed wastes in the fall of 1997. This paper describes the technology, its performance, the technology applicability and alternatives, cost, regulatory and policy issues, and lessons learned.

  12. Innovative camera system developed for Sprint vehicle

    SciTech Connect

    Not Available

    1985-04-01

    A new inspection system for the Sprint 101 ROV eliminates parallax errors because all three camera modules use a single lens for viewing. Parallax is the apparent displacement of an object when it is viewed from two points not in the same line of sight. The central camera is a Pentax 35-mm single lens reflex with a 28-mm lens. It comes with 250-shot film cassettes, an automatic film wind-on, and a data chamber display. An optical transfer assembly on the stills camera viewfinder transmits the image to one of the two video camera modules. The video picture transmitted to the surface is exactly the same as the stills photo. The surface operator can adjust the focus by viewing the video display.

  13. Systems effects on family planning innovativeness.

    PubMed

    Lee, S B

    1983-12-01

    Data from Korea were used to explore the importance of community level variables in explaining family planning adoption at the individual level. An open system concept was applied, assuming that individual family planning behavior is influenced by both environmental and individual factors. The environmental factors were measured at the village level and designated as community characteristics. The dimension of communication network variables was introduced. Each individual was characterized in terms of the degree of her involvement in family planning communication with others in her village. It was assumed that the nature of the communication network linking individuals with each other effects family planning adoption at the individual level. Specific objectives were to determine 1) the relative importance of the specific independent variables in explaining family planning adoption and 2) the relative importance of the community level variables in comparison with the individual level variables in explaining family planning adoption at the individual level. The data were originally gathered in a 1973 research project on Korea's mothers' clubs. 1047 respondents were interviewed, comprising all married women in 25 sample villages having mothers' clubs. The dependent variable was family planning adoption behavior, defined as current use of any of the modern methods of family planning. The independent variables were defined at 3 levels: individual, community, and at a level intermediate between them involving communication links between individuals. More of the individual level independent variables were significantly correlated with the dependent variables than the community level variables. Among those variables with statistically significant correlations, the correlation coefficients were consistently higher for the individual level than for the community level variables. More of the variance in the dependent variable was explained by individual level than by

  14. Creating a Framework for Research on Systemic Technology Innovations

    ERIC Educational Resources Information Center

    Fishman, Barry; Marx, Ronald W.; Blumenfeld, Phyllis; Krajcik, Joseph; Soloway, Elliot

    2004-01-01

    This article examines why cognitively oriented technology innovations, designed to foster deep thinking and learning, have not become widespread in K-12 schools. We argue a key reason is that most design-based research does not explicitly address systemic issues of usability, scalability and sustainability. This limitation must be overcome if…

  15. Small Business Innovation Research Award Success Story: Proton Energy Systems

    SciTech Connect

    2011-04-01

    This success story describes Proton Energy Systems, a small business that designs and manufactures proton exchange membrane (PEM) electrolysis sytems to produce hydrogen from water. The U.S. Department of Energy's Fuel Cell Technologies Program has supported much of Proton's technology development through Small Business Innovation Research (SBIR) Awards and other non-SBIR funding.

  16. Innovations and Neutralizations in the Warlpiri Pronominal System.

    ERIC Educational Resources Information Center

    Bavin, E. L.; Shopen, T.

    1987-01-01

    Discusses the progress in the number of innovations and neutralizations in the pronominal system of Warlpiri, an aboriginal language spoken in central Australia. The changes are analyzed by age-group usage, and patterns of the changes are suggested. Part of a sample interview in presented. (Author/LMO)

  17. A Review of Innovation Systems Framework as a Tool for Gendering Agricultural Innovations: Exploring Gender Learning and System Empowerment

    ERIC Educational Resources Information Center

    Kingiri, Ann N.

    2013-01-01

    Purpose: To reflect on the opportunities that a systems understanding of innovation provides for addressing gender issues relevant to women, and to provide some insight on how these might be tackled. Approach: Review of literature relating to gender issues and how they relate to achieving, on the one hand, equity and efficiency goals, and on the…

  18. Innovation in Extraterrestrial Service Systems - A Challenge for Service Science

    NASA Technical Reports Server (NTRS)

    Bergner, David

    2010-01-01

    This presentation was prepared at the invitation of Professor Yukio Ohsawa, Department of Systems Innovation, School of Engineering, The University of Tokyo, for delivery at the International Workshop on Innovating Service Systems, sponsored by the Japanese Society of Artificial Intelligence (JSAI) as part of the JSAI Internation Symposium on AI, 2010. It offers several challenges for Service Science and Service Innovation. the goal of the presentation is to stimulate thinking about how service systems viII evolve in the future, as human society advances from its terrestrial base toward a permanent presence in space. First we will consider the complexity of the International Space Station (ISS) as it is today, with particular emphasis of its research facilities, and focus on a current challenge - to maximize the utilization of ISS research facilities for the benefit of society. After briefly reviewing the basic principles of Service Science, we will discuss the potential application of Service Innovation methodology to this challenge. Then we viII consider how game-changing technologies - in particular Synthetic Biology - could accelerate the pace of sociocultural evolution and consequently, the progression of human society into space. We will use this provocative vision to advance thinking about how the emerging field of Service Science, Management, and Engineering (SSME) might help us anticipate and better handle the challenges of this inevitable evolutionary process.

  19. The influenza vaccine innovation system and lessons for PDPs.

    PubMed

    Huzair, Farah

    2012-03-01

    As Product Development Partnerships (PDPs) emerge and evolve in response to the need for vaccines, this paper re-examines the oldest and most successful PDP in the vaccine field; that which year after year, produces and reinvents influenza vaccines. This paper describes the influenza vaccine production and innovation system and reviews some of its most recent major innovations. Innovation in this system is a result of collaborative partnerships between various actors from both the public and private sector. It is argued that the influenza vaccine innovation system is a Product Development Partnership (PDP), be it an unconventional one, with a central coordination role allocated to the WHO rather than a private company or charitable/not for profit entity. The unusual structure of this PDP overcomes some of the organizational issues surrounding vaccine research and production faced by other documented PDPs. These are first, the need to coordinate knowledge flow via an effective knowledge broker. Second, the need to build in-house capacity and fund essential research and elements of production where private partners find involvement too risky or costly. PMID:22327495

  20. The influenza vaccine innovation system and lessons for PDPs.

    PubMed

    Huzair, Farah

    2012-03-01

    As Product Development Partnerships (PDPs) emerge and evolve in response to the need for vaccines, this paper re-examines the oldest and most successful PDP in the vaccine field; that which year after year, produces and reinvents influenza vaccines. This paper describes the influenza vaccine production and innovation system and reviews some of its most recent major innovations. Innovation in this system is a result of collaborative partnerships between various actors from both the public and private sector. It is argued that the influenza vaccine innovation system is a Product Development Partnership (PDP), be it an unconventional one, with a central coordination role allocated to the WHO rather than a private company or charitable/not for profit entity. The unusual structure of this PDP overcomes some of the organizational issues surrounding vaccine research and production faced by other documented PDPs. These are first, the need to coordinate knowledge flow via an effective knowledge broker. Second, the need to build in-house capacity and fund essential research and elements of production where private partners find involvement too risky or costly.

  1. Services Systems to Leverage Innovators' Knowledge: The Telecoms Industry Case

    NASA Astrophysics Data System (ADS)

    Bugeaud, Florie; Soulier, Eddie

    Today, telecoms operators have to prove their innovation capacity. They address corporate customers which are involved in collaborative value networks. They implement a process of new services research in order to create adapted solutions. This process is linked to a collaborative and complex practice between diverse innovators. However there is no structured method to leverage this community’s knowledge. Based on the SSME discussions, we suggest enriching the telecoms innovation approaches by the representation and the simulation of "services systems". This paper also proposes the development of a collaborative tool to support this suggestion and the innovators’ practices. Our approach is currently tested on a specific telecom service in the e-health domain which presents an interesting business ecosystem.

  2. Spreading nursing unit innovation in large hospital systems.

    PubMed

    Pearson, Marjorie L; Upenieks, Valda V; Yee, Tracy; Needleman, Jack

    2008-03-01

    Healthcare administrators increasingly face the challenge of how to spread innovation throughout their organizations. The authors present the results of an evaluation of the efforts of 3 major hospital systems to internally disseminate nursing unit change among medical-surgical units. The findings show that all 3 organizations carefully planned, coordinated, and implemented a spread process; none left dissemination to chance. Although clear differences were evident in the way they engineered their spread, many similarities also were found.

  3. 75 FR 70741 - Innovative Energy Systems, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Innovative Energy Systems, LLC; Supplemental Notice That Initial Market... supplemental notice in the above-referenced proceeding Innovative Energy Systems, LLC's application for...

  4. Innovative power conversion system for the French SFR prototype, ASTRID

    SciTech Connect

    Cachon, L.; Biscarrat, C.; Morin, F.; Haubensack, D.; Rigal, E.; Moro, I.; Baque, F.; Madeleine, S.; Rodriguez, G.; Laffont, G.

    2012-07-01

    In the framework of the French Act of 28 June 2006 about nuclear materials and waste management, the prototype ASTRID (Advanced Sodium Technological Reactor for Industrial Demonstration), foreseen in operation by the 20's, will have to demonstrate not only the minor actinide transmutation capability, but also the progress made in Sodium Fast Reactor (SFR) technology on an industrial scale, by qualifying innovative options. Some of these options still require improvements, especially in the field of operability and safety. In fact, one of the main issues with the standard steam/water Power Conversion System (PCS) of SFR is the fast and energetic chemical reaction between water and sodium, which could occur in steam generators in case of tube failure. To manage the sodium/water reaction, one way consists in minimizing the impact of such event: hence studies are carried out on steam generator design, improvement of the physical knowledge of this phenomenon, development of numerical simulation to predict the reaction onset and consequences, and associated detection improvement. On the other hand, the other way consists in eliminating sodium/water reaction. In this frame, the CEA contribution to the feasibility evaluation of an alternative innovative PCS (replacing steam/water by 180 bar pressurised nitrogen) is focused on the following main topics: - The parametric study leading to nitrogen selection: the thermodynamic cycle efficiency optimisation on Brayton cycles is performed with several gases at different pressures. - The design of innovative compact heat exchangers for the gas loop: here the key points are the nuclear codification associated with inspection capability, the innovative welding process and the thermal-hydraulic and thermal-mechanic optimisations. After a general introduction of the ASTRID project, this paper presents in detail these different feasibility studies being led on the innovative gas PCS for an SFR. (authors)

  5. An innovative algorithm for panoramic representation in observation systems

    NASA Astrophysics Data System (ADS)

    Luison, Cristian; Aquilanti, Valeria; Riccobono, Aldo; Liberace, Claudio

    2013-06-01

    This document presents the study and test carried out for the development of an innovative algorithm designed to create a panoramic representation of the scene scanned by observation systems operating with passive sensors. The purpose of the algorithm is to represent 360° of scene using staring sensors mounted on stabilized or semi-stabilized platforms, without requirements on video output, both in terms of the transmission format and in terms of frame rate. The algorithm is real-time and does not require step-and-stare technique or special systems to scan the scene. The architecture of the algorithm requires a very low computational cost for the electronics contained in a Multi-Functional Display (MDP) used in defense applications. The algorithm has been implemented and tested on the JANUS NAVAL system, where the results were very satisfactory. Today, a patent is pendent.

  6. Co-simulation of innovative integrated HVAC systems in buildings

    SciTech Connect

    Trcka, Marija; Hensena, Jan L.M.; Wetter, Michael

    2010-06-21

    Integrated performance simulation of buildings HVAC systems can help in reducing energy consumption and increasing occupant comfort. However, no single building performance simulation (BPS) tool offers sufficient capabilities and flexibilities to analyze integrated building systems and to enable rapid prototyping of innovative building and system technologies. One way to alleviate this problem is to use co-simulation, as an integrated approach to simulation. This article elaborates on issues important for co-simulation realization and discusses multiple possibilities to justify the particular approach implemented in the here described co-simulation prototype. The prototype is validated with the results obtained from the traditional simulation approach. It is further used in a proof-of-concept case study to demonstrate the applicability of the method and to highlight its benefits. Stability and accuracy of different coupling strategies are analyzed to give a guideline for the required coupling time step.

  7. Optics designs for an innovative LED lamp family system

    NASA Astrophysics Data System (ADS)

    Weiss, Herbert; Muschaweck, Julius; Hadrath, Stefan; Kudaev, Sergey

    2011-10-01

    On the general lighting market of LED lamps for professional applications there are still mainly products for single purpose solutions existing. There is a lack of standardised lamp systems like they are common for conventional lighting technologies. Therefore, an LED lamp family system was studied using high power LED with the objective to entirely substitute standard conventional lamp families in general lighting applications in the professional market segment. This comprises the realization of sets of lamp types with compact and linear shapes as well as with light distribution characteristics ranging from diffuse to extreme collimation and exceptionally high candle power. Innovative secondary optics concepts are discussed which allow both, the design of lamps with non-bulky shape and to obtain sufficient colour mixing when using multicolour LED combinations in order to achieve a very high colour rendering quality.

  8. Innovative Detection System of Ochratoxin A by Thin Film Photodiodes

    PubMed Central

    Caputo, Domenico; de Cesare, Giampiero; Fanelli, Corrado; Nascetti, Augusto; Ricelli, Alessandra; Scipinotti, Riccardo

    2007-01-01

    In this work we present, for the first time, a rapid, compact and innovative method for detection of Ochratoxin A (OTA) based on hydrogenated amorphous silicon (a-Si:H) sensors. 2 μl of acidified toluene containing OTA at different concentrations were spotted on the silica side of a High Performance Thin Layer Cromatography plate and aligned with a a-Si:H p-i-n photodiode deposited by Plasma Enhanced Chemical Vapor Deposition on a different glass substrate. As an UV radiation excites the mycotoxin, the re-emitted light is detected by the a-Si:H sensor. Results show a very good linearity between OTA concentration and the sensor photocurrent over almost three orders of magnitude. The minimum detected OTA concentration is equal to 0.1ng, showing that the presented system has the potential for a low cost system suitable for the early detection of toxins in foods.

  9. Innovative production system goes in off Ivory Coast

    SciTech Connect

    Childers, M.; Barnes, J. |

    1995-07-17

    The phased field development of the Lion and Panthere fields, offshore the Ivory Coast, includes a small floating production, storage, and offloading (FPSO) tanker with minimal processing capability as an early oil production system (EPS). For the long-term production scheme, the FPSO will be replaced by a converted jack up mobile offshore production system (MOPS) with full process equipment. The development also includes guyed-caisson well platforms, pipeline export for natural gas to fuel an onshore power plant, and a floating storage and offloading (FSO) tanker for oil export. Pipeline export for oil is a future possibility. This array of innovative strategies and techniques seldom has been brought together in a single project. The paper describes the development plan, early oil, jack up MOPS, and transport and installation.

  10. Design and Implementation of an Innovative Residential PV System

    NASA Astrophysics Data System (ADS)

    Najm, Elie Michel

    This work focuses on the design and implementation of an innovative residential PV system. In chapter one, after an introduction related to the rapid growth of solar systems' installations, the most commonly used state of the art solar power electronics' configurations are discussed, which leads to introducing the proposed DC/DC parallel configuration. The advantages and disadvantages of each of the power electronics' configurations are deliberated. The scope of work in the power electronics is defined in this chapter to be related to the panel side DC/DC converter. System integration and mechanical proposals are also within the scope of work and are discussed in later chapters. Operation principle of a novel low cost PV converter is proposed in chapter 2. The proposal is based on an innovative, simplified analog implementation of a master/slave methodology resulting in an efficient, soft-switched interleaved variable frequency flybacks, operating in the boundary conduction mode (BCM). The scheme concept and circuit configuration, operation principle and theoretical waveforms, design equations, and design considerations are presented. Furthermore, design examples are also given, illustrating the significance of the newly derived frequency equation for flybacks operating in BCM. In chapters 3, 4, and 5, the design implementation and optimization of the novel DC/DC converter illustrated in chapter 2 are discussed. In chapter 3, a detailed variable frequency BCM flyback design model leading to optimizing the component selections and transformer design, detailed in chapter 4, is presented. Furthermore, in chapter 4, the method enabling the use of lower voltage rating switching devices is also discussed. In chapter 5, circuitry related to Start-UP, drive for the main switching devices, zero-voltage-switching (ZVS) as well as turn OFF soft switching and interleaving control are fully detailed. The experimental results of the proposed DC/DC converter are presented in

  11. An evaluation of some innovative fragmentation systems for oil shale

    SciTech Connect

    Hieta, M.; Hustrulid, W.A.

    1991-06-01

    This report describes a large-scale underground mining method, large-hole stoping, using some innovative fragmentation systems (buffer blasting, continuous loading/hauling, and mechanical miners for development). This study includes a literature review and an experimental study of one of the key design factors--buffer blasting. The purpose of the buffer-blasting experiments is to examine the swell that is necessary to achieve satisfactory fragmentation results. The study also includes a technical and economic evaluation of the new mining method compared with conventional room and pillar mining. The purpose of this study is to examine innovative methods that exist today and may provide a more efficient mining system than that currently used. Note that this is a conceptual study, and that the mining for the two mine designs were compared using a daily production rate of 75,000 tones per day. This amount was chosen because it is the maximum amount possible for a rubber-tired room and pillar operation with only a one-shaft complex.

  12. A highly innovative global broadband mobile communication system concept

    NASA Astrophysics Data System (ADS)

    Wittig, Manfred

    2010-04-01

    Global mobile communication systems deployed in the 1990s (Iridium and Globalstar) failed to achieve the expected market success. However, recently a second generation of these two LEO constellations have been or will be procured. This shows evidence that global mobile satellite communications are attractive for a certain class of users. Basic requirements for mobile satellite communication networks are global coverage at high elevation angles, continuous availability and most important attractive service offers. For the first two reasons LEO constellations were designed and deployed. The large number of required satellites (remember the original Teledesic concept was designed containing 860 satellites) increases the CAPEX and consequently the service cost. This is probably the major reason for the limited commercial success of Iridium and Globalstar. An ideal global mobile (broadband) communication system shall provide global coverage at high elevation angles (not below e.g. 30°) with the lowest number of satellites. This seems to be contradictory. However, a solution will be presented that achieves global coverage which requires only five satellites and achieves high elevation angles even at polar locations. This orbit constellation is to be complemented with innovative payloads to achieve cost efficient broadband mobile services all over the Globe. Innovative L/S-band payload concepts will be introduced as well as Ka-band payloads.

  13. Innovative tephra studies in the East African Rift System

    NASA Astrophysics Data System (ADS)

    WoldeGabriel, Giday; Hart, William K.; Heiken, Grant

    Geosciences investigations form the foundation for paleoanthropological research in the East African Rift System. However, innovative applications of tephra studies for constraining spatial and temporal relations of diverse geological processes, biostratigraphic records, and paleoenvironmental conditions within the East African Rift System were fueled by paleoanthropological investigations into the origin and evolution of hominids and material culture. Tephra is a collective, size-independent term used for any material ejected during an explosive volcanic eruption.The East African Rift System has become a magnet for paleoanthropological research ever since the discovery of the first hominids at Olduvai Gorge, in Tanzania, in the 1950s [Leakey et al., 1961]. Currently, numerous multidisciplinary scientific teams from academic institutions in the United States and Western Europe make annual pilgrimages for a couple of months to conduct paleoanthropological field research in the fossil-rich sedimentary deposits of the East African Rift System in Ethiopia, Kenya, and Tanzania. The field expedition consists of geological, paleontological, archaeological, and paleoenvironmental investigations.

  14. Agricultural Innovation Systems (AIS): A Study of Stakeholders and Their Relations in System of Rice Intensification (SRI)

    ERIC Educational Resources Information Center

    Suchiradipta, Bhattacharjee; Raj, Saravanan

    2015-01-01

    Purpose: This paper identifies the stakeholders of System of Rice Intensification (SRI), their roles and actions and the supporting and enabling environment of innovation in the state as the elements of the Agricultural Innovation Systems (AIS) in SRI in Tripura state of India and studies the relationship matrix among the stakeholders.…

  15. Pipe Explorer{trademark} surveying system. Innovative technology summary report

    SciTech Connect

    Not Available

    1999-06-01

    The US Department of Energy`s (DOE) Chicago Operations Office and the DOE`s Federal Energy Technology Center (FETC) developed a Large Scale Demonstration Project (LSDP) at the Chicago Pile-5 Research Reactor (CP-5) at Argonne National Laboratory-East (ANL). The objective of the LSDP is to demonstrate potentially beneficial decontamination and decommissioning (D and D) technologies in comparison with current baseline technologies. The Pipe Explorer{trademark} system was developed by Science and Engineering Associates, Inc. (SEA), Albuquerque, NM as a deployment method for transporting a variety of survey tools into pipes and ducts. Tools available for use with the system include alpha, beta and gamma radiation detectors; video cameras; and pipe locator beacons. Different versions of this technology have been demonstrated at three other sites; results of these demonstrations are provided in an earlier Innovative Technology Summary Report. As part of a D and D project, characterization radiological contamination inside piping systems is necessary before pipes can be recycled, remediated or disposed. This is usually done manually by surveying over the outside of the piping only, with limited effectiveness and risk of worker exposure. The pipe must be accessible to workers, and embedded pipes in concrete or in the ground would have to be excavated at high cost and risk of exposure to workers. The advantage of the Pipe Explorer is its ability to perform in-situ characterization of pipe internals.

  16. Heat stress monitoring system. Innovative technology summary report

    SciTech Connect

    1998-11-01

    The US Department of Energy`s (DOE) nuclear facility decontamination and decommissioning (D and D) program involves the need to decontaminate and decommission buildings expeditiously and cost-effectively. Simultaneously, the health and safety of personnel involved in the D and D activities is of primary concern. Often, D and D workers must perform duties in inclement weather, and because they also frequently work in contaminated areas, they must wear personal protective clothing and/or respirators. Monitoring the health status of workers under these conditions is an important component of ensuring their safety. The MiniMitter VitalSense Telemetry System`s heat stress monitoring system (HSMS) is designed to monitor the vital signs of individual workers as they perform work in conditions that might be conducive to heat exhaustion or heat stress. The HSMS provides real-time data on the physiological condition of workers which can be monitored to prevent heat stress or other adverse health situations. This system is particularly useful when workers are wearing personal protective clothing or respirators that make visual observation of their condition more difficult. The MiniMitter VitalSense Telemetry System can monitor up to four channels (e.g., heart rate, body activity, ear canal, and skin temperature) and ten workers from a single supervisory station. The monitors are interfaced with a portable computer that updates and records information on individual workers. This innovative technology, even though it costs more, is an attractive alternative to the traditional (baseline) technology, which measures environmental statistics and predicts the average worker`s reaction to those environmental conditions without taking the physical condition of the individual worker into consideration. Although use of the improved technology might be justified purely on the basis of improved safety, it has the potential to pay for itself by reducing worker time lost caused by heat

  17. A New Approach for Analysing National Innovation Systems in Emerging and Developing Countries

    ERIC Educational Resources Information Center

    Seidel, Uwe; Muller, Lysann; Meier zu Kocker, Gerd; Filho, Guajarino de Araujo

    2013-01-01

    This paper presents a tool for the indicator-based analysis of national innovation systems (ANIS). ANIS identifies the economic strengths and weaknesses of a country-wide, regional or local system and includes a comprehensive examination and evaluation of the status of existing innovation systems. The use of a particular form of expert interviews…

  18. Technological innovations in the development of cardiovascular clinical information systems.

    PubMed

    Hsieh, Nan-Chen; Chang, Chung-Yi; Lee, Kuo-Chen; Chen, Jeen-Chen; Chan, Chien-Hui

    2012-04-01

    Recent studies have shown that computerized clinical case management and decision support systems can be used to assist surgeons in the diagnosis of disease, optimize surgical operation, aid in drug therapy and decrease the cost of medical treatment. Therefore, medical informatics has become an extensive field of research and many of these approaches have demonstrated potential value for improving medical quality. The aim of this study was to develop a web-based cardiovascular clinical information system (CIS) based on innovative techniques, such as electronic medical records, electronic registries and automatic feature surveillance schemes, to provide effective tools and support for clinical care, decision-making, biomedical research and training activities. The CIS developed for this study contained monitoring, surveillance and model construction functions. The monitoring layer function provided a visual user interface. At the surveillance and model construction layers, we explored the application of model construction and intelligent prognosis to aid in making preoperative and postoperative predictions. With the use of the CIS, surgeons can provide reasonable conclusions and explanations in uncertain environments.

  19. Indigenous African Knowledge Systems and Innovation in Higher Education in South Africa

    ERIC Educational Resources Information Center

    Higgs, P.; Higgs, L. G.; Venter, E.

    2003-01-01

    The importance of innovation in higher education is recognised in South African educational discourse. The South African White Paper on Science and Technology, issued in September 1996 and entitled, "Preparing for the 21st Century", states that, "the White Paper is built upon the twin concepts of "innovation" and a "national system of innovation"…

  20. TESTING AND PERFORMANCE EVALUATION OF AN INNOVATIVE INTERNAL PIPE SEALING SYSTEM FOR WASTEWATER MAIN REHABILITATION

    EPA Science Inventory

    Many utilities are seeking emerging and innovative rehabilitation technologies to extend the service life of their infrastructure systems. This report describes the testing and performance evaluation of an internal pipe sealing system, which provides a permanent physical seal fo...

  1. Innovative Distributed Power Grid Interconnection and Control Systems: Final Report, December 11, 2000 - August 30, 2005

    SciTech Connect

    DePodesta, K.; Birlingmair, D.; West, R.

    2006-03-01

    The contract goal was to further advance distributed generation in the marketplace by making installations more cost-effective and compatible with existing systems. This was achieved by developing innovative grid interconnection and control systems.

  2. An innovative forecasting and dashboard system for Malaysian dengue trends

    NASA Astrophysics Data System (ADS)

    Jamil, Jastini Mohd; Shaharanee, Izwan Nizal Mohd

    2016-08-01

    Dengue fever has been recognized in over 100 countries and 2.5 billion people live in areas where dengue is endemic. It is currently a serious arthropod-borne disease, affecting around 50-100 million people worldwide every year. Dengue fever is also prevalent in Malaysia with numerous cases including mortality recorded over the past year. In 2012, a total of 21,900 cases of dengue fever were reported with 35 deaths. Dengue, a mosquito-transmitted virus, causes a high fever accompanied by significant pain in afflicted patient and the Aedes Aegypti mosquito is the primary disease carrier. Knowing the dangerous effect of dengue fever, thus one of the solutions is to implement an innovative forecasting and dashboard system of dengue spread in Malaysia, with emphasize on an early prediction of dengue outbreak. Specifically, the model developed will provide with a valuable insight into strategically managing and controlling the future dengue epidemic. Importantly, this research will deliver the message to health policy makers such as The Ministry of Health Malaysia (MOH), practitioners, and researchers of the importance to integrate their collaboration in exploring the potential strategies in order to reduce the future burden of the increase in dengue transmission cases in Malaysia.

  3. Implementation of a Technological Innovation: Factors Influencing the Adoption of a New Student Information System

    ERIC Educational Resources Information Center

    Johnston, Katrina M.

    2013-01-01

    School information systems (SIS) have the potential to cause a change in a school's technical, structural, psycho-social, and managerial systems. Implementation of a technological innovation such as an SIS is not a one-step occurrence; it is a process that occurs over time. Implementing any technological innovation involves active learning…

  4. The Practice Teaching Platform and System for Innovating Talents and Performing Research

    ERIC Educational Resources Information Center

    Wang, Boyu; Hao, Ziqiang

    2014-01-01

    The practice education is an important part of higher educational system and an important approach to cultivating applied innovative talents. This paper studies practice of teaching platform and practical teaching system for the research and practice based on the objective basis of applied innovative talents and the basic characteristics of the…

  5. Biopharmaceutical Innovation System in China: System Evolution and Policy Transitions (Pre-1990s-2010s)

    PubMed Central

    Hu, Hao; Chung, Chao-Chen

    2015-01-01

    Background: This article sets up the initial discussion of the evolution of biopharmaceutical innovation in China through the perspective of sectoral innovation system (SIS). Methods: Two data sources including archival documentary data and field interviews were used in this study. Archival documentary data was collected from China Food and Drug Administration (CFDA) and Chinese National Knowledge Infrastructure (CNKI). In addition, industrial practitioners and leading researchers in academia were interviewed. Results: Biopharmaceutical in China was established through international knowledge transfer. The firms played more active role in commercializing biopharmaceutical in China though universities and research institutes were starting to interact with local firms and make contribution to biopharmaceutical industrialization. The transition of the Chinese government’s policies continuously shapes the evolution of biopharmaceutical sector. Policies have been dramatic changes before and after 1980s to encourage developing biopharmaceutical as a competitive industry for China. Conclusion: A SIS for biopharmaceutical has been shaped in China. However, currently biopharmaceutical is still a small sector in China, and for the further growth of the industry more synthetic policies should be implemented. Not only the policy supports towards the research and innovation of biopharmaceuticals in the early stage of development should be attended, but also commercialization of biopharmaceutical products in the later stage of sales. PMID:26673466

  6. Course Management Systems and Blended Learning: An Innovative Learning Approach

    ERIC Educational Resources Information Center

    Chou, Amy Y.; Chou, David C.

    2011-01-01

    This article utilizes Rogers' innovation-decision process model (2003) and Beckman and Berry's innovation process model (2007) to create an innovative learning map that illustrates three learning methods (i.e., face-to-face learning, online learning, and blended learning) in two types of innovation (i.e., incremental innovation and radical…

  7. Health Systems Innovation at Academic Health Centers: Leading in a New Era of Health Care Delivery.

    PubMed

    Ellner, Andrew L; Stout, Somava; Sullivan, Erin E; Griffiths, Elizabeth P; Mountjoy, Ashlin; Phillips, Russell S

    2015-07-01

    Challenged by demands to reduce costs and improve service delivery, the U.S. health care system requires transformational change. Health systems innovation is defined broadly as novel ideas, products, services, and processes-including new ways to promote healthy behaviors and better integrate health services with public health and other social services-which achieve better health outcomes and/or patient experience at equal or lower cost. Academic health centers (AHCs) have an opportunity to focus their considerable influence and expertise on health systems innovation to create new approaches to service delivery and to nurture leaders of transformation. AHCs have traditionally used their promotions criteria to signal their values; creating a health systems innovator promotion track could be a critical step towards creating opportunities for innovators in academic medicine. In this Perspective, the authors review publicly available promotions materials at top-ranked medical schools and find that while criteria for advancement increasingly recognize systems innovation, there is a lack of specificity on metrics beyond the traditional yardstick of peer-reviewed publications. In addition to new promotions pathways and alternative evidence for the impact of scholarship, other approaches to fostering health systems innovation at AHCs include more robust funding for career development in health systems innovation, new curricula to enable trainees to develop skills in health systems innovation, and new ways for innovators to disseminate their work. AHCs that foster health systems innovation could meet a critical need to contribute both to the sustainability of our health care system and to AHCs' continued leadership role within it.

  8. Health Systems Innovation at Academic Health Centers: Leading in a New Era of Health Care Delivery.

    PubMed

    Ellner, Andrew L; Stout, Somava; Sullivan, Erin E; Griffiths, Elizabeth P; Mountjoy, Ashlin; Phillips, Russell S

    2015-07-01

    Challenged by demands to reduce costs and improve service delivery, the U.S. health care system requires transformational change. Health systems innovation is defined broadly as novel ideas, products, services, and processes-including new ways to promote healthy behaviors and better integrate health services with public health and other social services-which achieve better health outcomes and/or patient experience at equal or lower cost. Academic health centers (AHCs) have an opportunity to focus their considerable influence and expertise on health systems innovation to create new approaches to service delivery and to nurture leaders of transformation. AHCs have traditionally used their promotions criteria to signal their values; creating a health systems innovator promotion track could be a critical step towards creating opportunities for innovators in academic medicine. In this Perspective, the authors review publicly available promotions materials at top-ranked medical schools and find that while criteria for advancement increasingly recognize systems innovation, there is a lack of specificity on metrics beyond the traditional yardstick of peer-reviewed publications. In addition to new promotions pathways and alternative evidence for the impact of scholarship, other approaches to fostering health systems innovation at AHCs include more robust funding for career development in health systems innovation, new curricula to enable trainees to develop skills in health systems innovation, and new ways for innovators to disseminate their work. AHCs that foster health systems innovation could meet a critical need to contribute both to the sustainability of our health care system and to AHCs' continued leadership role within it. PMID:25738387

  9. Development and innovation on integrated engineering optics system design

    NASA Astrophysics Data System (ADS)

    Ding, Quanxin; Liu, Hua; Zhou, Liwei

    2010-10-01

    Answer the new challenge in project research and development on multiple subjects multiple domain, engineering optics, system design and essential methods applied to structure effective system. Base on system engineering theory, traditional optical design optimization is developed. General global optimization, which based on central optics system integrated with up-to-date comprehensive modules and methods in created way, is presented and supported by abundant results of research and development, especially on multiple configuration and adaptive system optimization. Advantages such as system intellect, response ability, research periods, venture eluding and compatibility for renew situations demonstrate validity and potential.

  10. "Power quality system," a new system of quality management for globalization: towards innovation and competitive advantages.

    PubMed

    Abdul-Rahman, H; Berawi, M A

    Knowledge Management (KM) addresses the critical issues of organizational adoption, survival and competence in the face of an increasingly changing environment. KM embodies organizational processes that seek a synergistic combination of the data and information processing capabilities of information and communication technologies (ICT), and the creative and innovative capacity of human beings to improve ICT In that role, knowledge management will improve quality management and avoid or minimize losses and weakness that usually come from poor performance as well as increase the competitive level of the company and its ability to survive in the global marketplace. To achieve quality, all parties including the clients, company consultants, contractors, entrepreneurs, suppliers, and the governing bodies (i.e., all involved stake-holders) need to collaborate and commit to achieving quality. The design based organizations in major business and construction companies have to be quality driven to support healthy growth in today's competitive market. In the march towards vision 2020 and globalization (i.e., the one world community) of many companies, their design based organizations need to have superior quality management and knowledge management to anticipate changes. The implementation of a quality system such as the ISO 9000 Standards, Total Quality Management, or Quality Function Deployment (QFD) focuses the company's resources towards achieving faster and better results in the global market with less cost. To anticipate the needs of the marketplace and clients as the world and technology change, a new system, which we call Power Quality System (PQS), has been designed. PQS is a combination of information and communication technologies (ICT) and the creative and innovative capacity of human beings to meet the challenges of the new world business and to develop high quality products. PMID:12465710

  11. "Power quality system," a new system of quality management for globalization: towards innovation and competitive advantages.

    PubMed

    Abdul-Rahman, H; Berawi, M A

    Knowledge Management (KM) addresses the critical issues of organizational adoption, survival and competence in the face of an increasingly changing environment. KM embodies organizational processes that seek a synergistic combination of the data and information processing capabilities of information and communication technologies (ICT), and the creative and innovative capacity of human beings to improve ICT In that role, knowledge management will improve quality management and avoid or minimize losses and weakness that usually come from poor performance as well as increase the competitive level of the company and its ability to survive in the global marketplace. To achieve quality, all parties including the clients, company consultants, contractors, entrepreneurs, suppliers, and the governing bodies (i.e., all involved stake-holders) need to collaborate and commit to achieving quality. The design based organizations in major business and construction companies have to be quality driven to support healthy growth in today's competitive market. In the march towards vision 2020 and globalization (i.e., the one world community) of many companies, their design based organizations need to have superior quality management and knowledge management to anticipate changes. The implementation of a quality system such as the ISO 9000 Standards, Total Quality Management, or Quality Function Deployment (QFD) focuses the company's resources towards achieving faster and better results in the global market with less cost. To anticipate the needs of the marketplace and clients as the world and technology change, a new system, which we call Power Quality System (PQS), has been designed. PQS is a combination of information and communication technologies (ICT) and the creative and innovative capacity of human beings to meet the challenges of the new world business and to develop high quality products.

  12. The challenge of benchmarking health systems: is ICT innovation capacity more systemic than organizational dependent?

    PubMed

    Lapão, Luís Velez

    2015-01-01

    The article by Catan et al. presents a benchmarking exercise comparing Israel and Portugal on the implementation of Information and Communication Technologies in the healthcare sector. Special attention was given to e-Health and m-Health. The authors collected information via a set of interviews with key stakeholders. They compared two different cultures and societies, which have reached slightly different implementation outcomes. Although the comparison is very enlightening, it is also challenging. Benchmarking exercises present a set of challenges, such as the choice of methodologies and the assessment of the impact on organizational strategy. Precise benchmarking methodology is a valid tool for eliciting information about alternatives for improving health systems. However, many beneficial interventions, which benchmark as effective, fail to translate into meaningful healthcare outcomes across contexts. There is a relationship between results and the innovational and competitive environments. Differences in healthcare governance and financing models are well known; but little is known about their impact on Information and Communication Technology implementation. The article by Catan et al. provides interesting clues about this issue. Public systems (such as those of Portugal, UK, Sweden, Spain, etc.) present specific advantages and disadvantages concerning Information and Communication Technology development and implementation. Meanwhile, private systems based fundamentally on insurance packages, (such as Israel, Germany, Netherlands or USA) present a different set of advantages and disadvantages - especially a more open context for innovation. Challenging issues from both the Portuguese and Israeli cases will be addressed. Clearly, more research is needed on both benchmarking methodologies and on ICT implementation strategies. PMID:26301085

  13. Using an Interactive Systems Framework to Expand Telepsychology Innovations in Underserved Communities

    PubMed Central

    Alaniz, Angela B.

    2016-01-01

    Literature indicates that the use of promising innovations in mental health care can be improved. The advancement of telepsychology is one innovation that has been utilized as a method to reduce rural health disparities and increase the number of people with access to mental health services. This paper describes a successful pilot telepsychology program implemented in a rural community to increase access to mental health services and the model's replication and expansion into four additional communities using concepts described in an Interactive Systems Framework. The Interactive Systems Framework highlights how building local capacity specific to organizational functioning and innovations are necessary to support, deliver, and disseminate innovations within new settings. Based on the knowledge gained from this telepsychology innovation, the application of an Interactive Systems Framework and funding mechanisms are discussed. PMID:27403374

  14. Teams as innovative systems: multilevel motivational antecedents of innovation in R&D teams.

    PubMed

    Chen, Gilad; Farh, Jiing-Lih; Campbell-Bush, Elizabeth M; Wu, Zhiming; Wu, Xin

    2013-11-01

    Integrating theories of proactive motivation, team innovation climate, and motivation in teams, we developed and tested a multilevel model of motivators of innovative performance in teams. Analyses of multisource data from 428 members of 95 research and development (R&D) teams across 33 Chinese firms indicated that team-level support for innovation climate captured motivational mechanisms that mediated between transformational leadership and team innovative performance, whereas members' motivational states (role-breadth self-efficacy and intrinsic motivation) mediated between proactive personality and individual innovative performance. Furthermore, individual motivational states and team support for innovation climate uniquely promoted individual innovative performance, and, in turn, individual innovative performance linked team support for innovation climate to team innovative performance.

  15. 75 FR 7464 - Energy Efficient Building Systems Regional Innovation Cluster Initiative-Joint Federal Funding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... Announcement Information Session AGENCY: Department of Energy (DOE). ACTION: Notice of public meeting and... innovation in energy efficient building technologies and systems design. The DOE funded Energy Efficient... (the ``Energy Regional Innovation Cluster'' or ``E-RIC'') and will work to disseminate new...

  16. Proven Innovations and New Initiatives in Ground System Development

    NASA Technical Reports Server (NTRS)

    Gunn, Jody M.

    2006-01-01

    The state-of-the-practice for engineering and development of Ground Systems has evolved significantly over the past half decade. Missions that challenge ground system developers with significantly reduced budgets in spite of requirements for greater and previously unimagined functionality are now the norm. Making the right trades early in the mission lifecycle is one of the key factors to minimizing ground system costs. The Mission Operations Strategic Leadership Team at the Jet Propulsion Laboratory has spent the last year collecting and working through successes and failures in ground systems for application to future missions.

  17. Triple Helix Systems: An Analytical Framework for Innovation Policy and Practice in the Knowledge Society

    ERIC Educational Resources Information Center

    Ranga, Marina; Etzkowitz, Henry

    2013-01-01

    This paper introduces the concept of Triple Helix systems as an analytical construct that synthesizes the key features of university--industry--government (Triple Helix) interactions into an "innovation system" format, defined according to systems theory as a set of components, relationships and functions. Among the components of Triple…

  18. IN SITU STEAM ENHANCED RECOVERY PROCESS - HUGHES ENVIRONMENTAL SYSTEMS, INC. - INNOVATIVE TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    This Innovative Technology Evaluation report summarizes the findings of an evaluation of the in situ Steam Enhanced Recovery Process (SERP) operated by Hughes Environmental Systems, Inc. at the Rainbow Disposal facility in Huntington Beach, California. he technology demonstration...

  19. Innovation of laboratory exercises in course Distributed systems and computer networks

    NASA Astrophysics Data System (ADS)

    Souček, Pavel; Slavata, Oldřich; Holub, Jan

    2013-09-01

    This paper is focused on innovation of laboratory exercises in course Distributed Systems and Computer Networks. These exercises were introduced in November of 2012 and replaced older exercises in order to reflect real life applications.

  20. Building America Top Innovations 2013 Profile – Quality Management System Guidelines

    SciTech Connect

    none,

    2013-09-01

    This Top Innovation profile describes quality management system tools that were customized for residential construction by BSC, IBACOS, and PHI, for use by builders, trades, and designers to help eliminate mistakes that would require high-cost rework.

  1. Building America Top Innovations 2013 Profile – HPXML: A Standardized Home Performance Data Sharing System

    SciTech Connect

    none,

    2013-09-01

    This Top Innovation profile describes the Standard for Home Performance-Related Data Transfer (known as HPXML), developed by the National Renewable Energy Laboratory, which facilitates smooth communication between program tracking systems and energy upgrade analysis software,

  2. A Systems Dynamics Model of Implementation of an Innovation.

    ERIC Educational Resources Information Center

    Gaynor, Alan K.; And Others

    The research presented in this report investigated the critical factors that affected the decision to abandon or replace a curricular innovation in one elementary school. The specific innovation examined in this research is called developing mathematical processes, which emphasizes process and induction rather than computational skills. Although…

  3. Role of Universities in the National Innovation System. Discussion Paper

    ERIC Educational Resources Information Center

    Group of Eight (NJ1), 2011

    2011-01-01

    Over recent years governments have been placing more emphasis on innovation as a source of national competitiveness. Governments now assess their investments across many areas in terms of the contribution that such investments make to increasing innovation. This has been especially significant for education and in particular for the development of…

  4. Innovation in Open Systems: A Comparative Study of Banks.

    ERIC Educational Resources Information Center

    Young, Robert L.; And Others

    1981-01-01

    Explains the extent to which the innovativeness of banks (as measured by the adoption of credit cards and computers) is affected by competition, growth, size, and departmentalization. Notes that size and growth are more significantly related to innovation than are departmentalization and competition. (SB)

  5. Innovative use of global navigation satellite systems for flight inspection

    NASA Astrophysics Data System (ADS)

    Kim, Eui-Ho

    The International Civil Aviation Organization (ICAO) mandates flight inspection in every country to provide safety during flight operations. Among many criteria of flight inspection, airborne inspection of Instrument Landing Systems (ILS) is very important because the ILS is the primary landing guidance system worldwide. During flight inspection of the ILS, accuracy in ILS landing guidance is checked by using a Flight Inspection System (FIS). Therefore, a flight inspection system must have high accuracy in its positioning capability to detect any deviation so that accurate guidance of the ILS can be maintained. Currently, there are two Automated Flight Inspection Systems (AFIS). One is called Inertial-based AFIS, and the other one is called Differential GPS-based (DGPS-based) AFIS. The Inertial-based AFIS enables efficient flight inspection procedures, but its drawback is high cost because it requires a navigation-grade Inertial Navigation System (INS). On the other hand, the DGPS-based AFIS has relatively low cost, but flight inspection procedures require landing and setting up a reference receiver. Most countries use either one of the systems based on their own preferences. There are around 1200 ILS in the U.S., and each ILS must be inspected every 6 to 9 months. Therefore, it is important to manage the airborne inspection of the ILS in a very efficient manner. For this reason, the Federal Aviation Administration (FAA) mainly uses the Inertial-based AFIS, which has better efficiency than the DGPS-based AFIS in spite of its high cost. Obviously, the FAA spends tremendous resources on flight inspection. This thesis investigates the value of GPS and the FAA's augmentation to GPS for civil aviation called the Wide Area Augmentation System (or WAAS) for flight inspection. Because standard GPS or WAAS position outputs cannot meet the required accuracy for flight inspection, in this thesis, various algorithms are developed to improve the positioning ability of Flight

  6. Do entrepreneurial food systems innovations impact rural economies and health? Evidence and gaps

    PubMed Central

    Sitaker, Marilyn; Kolodinsky, Jane; Jilcott Pitts, Stephanie B.; Seguin, Rebecca A.

    2015-01-01

    A potential solution for weakened rural economies is the development of local food systems, which include affordable foods sources for consumers and economically feasible structures for producers. Local food systems are purported to promote sustainability, improve local economies, increase access to healthy foods, and improve the local diets. Four entrepreneurial food systems innovations that support local economies include farmers’ markets, community supported agriculture, farm to institution programs and food hubs. We review current literature to determine whether innovations for aggregation, processing, distribution and marketing in local food systems: 1) enable producers to make a living; 2) improve local economies; 3) provide local residents with greater access to affordable, healthy food; and 4) contribute to greater consumption of healthy food among residents. While there is some evidence for each, more transdisciplinary research is needed to determine whether entrepreneurial food systems innovations provide economic and public health benefits. PMID:26613066

  7. Building America Top Innovations 2012: Basement Insulation Systems

    SciTech Connect

    none,

    2013-01-01

    This Building America Top Innovations profile describes research on basement insulation, which identifies the wall installation methods and materials that perform best in terms of insulation and water resistance.

  8. An innovative nonintrusive driver assistance system for vital signal monitoring.

    PubMed

    Sun, Ye; Yu, Xiong Bill

    2014-11-01

    This paper describes an in-vehicle nonintrusive biopotential measurement system for driver health monitoring and fatigue detection. Previous research has found that the physiological signals including eye features, electrocardiography (ECG), electroencephalography (EEG) and their secondary parameters such as heart rate and HR variability are good indicators of health state as well as driver fatigue. A conventional biopotential measurement system requires the electrodes to be in contact with human body. This not only interferes with the driver operation, but also is not feasible for long-term monitoring purpose. The driver assistance system in this paper can remotely detect the biopotential signals with no physical contact with human skin. With delicate sensor and electronic design, ECG, EEG, and eye blinking can be measured. Experiments were conducted on a high fidelity driving simulator to validate the system performance. The system was found to be able to detect the ECG/EEG signals through cloth or hair with no contact with skin. Eye blinking activities can also be detected at a distance of 10 cm. Digital signal processing algorithms were developed to decimate the signal noise and extract the physiological features. The extracted features from the vital signals were further analyzed to assess the potential criterion for alertness and drowsiness determination. PMID:25375690

  9. In Situ Underwater Gamma Spectroscopy System. Innovative Technology Summary Report

    SciTech Connect

    2001-06-01

    The baseline approach to characterize underwater objects is to use radiation sensors on an extendable pole or the Remote Underwater Characterization System to detect gamma radiation and to collect samples for laboratory analysis to determine concentrations of specific radionuclides. The In-Situ Underwater Gamma Spectroscopy (ISUGS) System is essentially a submersible In-Situ Object Counting System from Canberra that can determine both the total gamma radiation and quantify the specific radionuclides contributing to the radiation. ISUGS was demonstrated to characterize objects in the canal of the Materials Test Reactor in INEEL's Test Reactor Area. Cost analysis based on demonstration data revealed that ISUGS reduced costs by 80% for characterization of ten objects compared to the baseline approach. Frammatome provides ISUGS as part of its characterization services. Based on these promising results, INEEL and other DOE sites plan to use ISUGS to characterize their reactor fuel pools.

  10. Defining Innovation: Using Soft Systems Methodology to Approach the Complexity of Innovation in Educational Technology

    ERIC Educational Resources Information Center

    Cox, Glenda

    2010-01-01

    This paper explores what educational technologists in one South African Institution consider innovation to be. Ten educational technologists in various faculties across the university were interviewed and asked to define and answer questions about innovation. Their answers were coded and the results of the overlaps in coding have been assimilated…

  11. Role of Brokerage in Evolving Innovation Systems: A Case of the Fodder Innovation Project in Nigeria

    ERIC Educational Resources Information Center

    Madzudzo, Elias

    2011-01-01

    This paper looks at brokerage functions in a project on building innovation capacity through improved networking. Innovation capacity influences how actors respond to changes in their environments. In such dynamic environments well connected sets of actors are at an advantage in that they can combine skills to address the emerging opportunities…

  12. Innovative Use of a Classroom Response System during Physics Lab

    ERIC Educational Resources Information Center

    Walgren, Jay

    2011-01-01

    More and more physics instructors are making use of personal/classroom response systems or "clickers." The use of clickers to engage students with multiple-choice questions during lecture and available instructor resources for clickers have been well documented in this journal. Newer-generation clickers, which I refer to as classroom response…

  13. Unconventional and Innovative: The Open Croquet Project. The Systems Librarian

    ERIC Educational Resources Information Center

    Breeding, Marshall

    2005-01-01

    This brief article gives a description of the Open Croquet Project and its applications. The project's Web site describes Croquet as a "combination of computer software and network architecture that supports deep collaboration and resource sharing among large numbers of users within the context of a large-scale distributed information system." One…

  14. Innovative relocation system for enclosures for MROI array telescopes

    NASA Astrophysics Data System (ADS)

    Busatta, A.; Ghedin, L.; Marchiori, G.; Mian, S.; Payne, I.; Pozzobon, M.

    2010-07-01

    Magdalena Ridge Observatory Interferometer (MROI) comprises an array of up to ten (10) 1.4m diameter mirror telescopes. Each of these ten telescopes will be housed inside a Unit Telescope Enclosure (UTE) which can be relocated, with the telescope inside, to any of 28 stations arranged in a "Y" configuration. These stations comprise fixed foundations with utility and data connections. There are four standard array configurations, the most compact of which one has less than 350 mm of space between the enclosures. This paper describes the relocation systems that were evaluated, including a rail based system, wheels or trolley fixed to the bottom of the enclosure, and various lifting mechanisms, all of which were analyzed to determine their performances related to the requirements. Eventually a relocation system utilizing a modified reachstacker (a transporter used to handle freight containers) has been selected. The reachstacker is capable of manoeuvring between and around the enclosures, is capable of lifting the combined weight of the enclosure with the telescope (40tons), and can manoeuvre the enclosure with minimal vibrations. A rigorous testing procedure has been performed to determine the vibrations induced in a dummy load in order to guarantee the safety of optics that must remain on the nasmyth table during the relocation. Finally we describe the lifting system, constituted by hydraulic jacks and locating pins, designed to lift and lower the enclosure and telescope during the precise positioning of the telescopes in the various stations.

  15. An innovative national health care waste management system in Kyrgyzstan.

    PubMed

    Toktobaev, Nurjan; Emmanuel, Jorge; Djumalieva, Gulmira; Kravtsov, Alexei; Schüth, Tobias

    2015-02-01

    A novel low-cost health care waste management system was implemented in all rural hospitals in Kyrgyzstan. The components of the Kyrgyz model include mechanical needle removers, segregation using autoclavable containers, safe transport and storage, autoclave treatment, documentation, recycling of sterilized plastic and metal parts, cement pits for anatomical waste, composting of garden wastes, training, equipment maintenance, and management by safety and quality committees. The gravity-displacement autoclaves were fitted with filters to remove pathogens from the air exhaust. Operating parameters for the autoclaves were determined by thermal and biological tests. A hospital survey showed an average 33% annual cost savings compared to previous costs for waste management. All general hospitals with >25 beds except in the capital Bishkek use the new system, corresponding to 67.3% of all hospital beds. The investment amounted to US$0.61 per capita covered. Acceptance of the new system by the staff, cost savings, revenues from recycled materials, documented improvements in occupational safety, capacity building, and institutionalization enhance the sustainability of the Kyrgyz health care waste management system. PMID:25649402

  16. An Innovative Improvement of Engineering Learning System Using Computational Fluid Dynamics Concept

    ERIC Educational Resources Information Center

    Hung, T. C.; Wang, S. K.; Tai, S. W.; Hung, C. T.

    2007-01-01

    An innovative concept of an electronic learning system has been established in an attempt to achieve a technology that provides engineering students with an instructive and affordable framework for learning engineering-related courses. This system utilizes an existing Computational Fluid Dynamics (CFD) package, Active Server Pages programming,…

  17. Innovative Compensation Systems: Implications for Employers, Unions, and Government. Background Paper No. 33.

    ERIC Educational Resources Information Center

    Schuster, Michael

    An examination of the innovative compensation systems called gainsharing, profit-sharing, pay-for-knowledge, two-tier wage plans, and lump sum bonuses has the following public policy implications: (1) more research is needed to evaluate the private and public sectors' experience with those alternative systems; (2) gainsharing and profit-sharing…

  18. Engineering America's Future in Space: Systems Engineering Innovations for Sustainable Exploration

    NASA Technical Reports Server (NTRS)

    Dumbacher, Daniel L.; Caruso, Pamela W.; Jones, Carl P.

    2008-01-01

    This viewgraph presentation reviews systems engineering innovations for Ares I and Ares V launch vehicles. The contents include: 1) NASA's Exploratoin Roadmap; 2) Launch Vehicle Comparisons; 3) Designing the Ares I and Ares V in House; 4) Exploring the Moon; and 5) Systems Engineering Adds Value Throughout the Project Lifecycle.

  19. The Systems Thinking and Curriculum Innovation Project. Technical Report, Part 1.

    ERIC Educational Resources Information Center

    Mandinach, Ellen B.; Thorpe, Margaret E.

    This document reports on the first year of the STACI (Systems Thinking and Curriculum Innovation) project, a two-year project which is examining the cognitive demands and consequences of using the STELLA (Structural Thinking Experimental Learning Laboratory with Animation) software to teach systems thinking, content knowledge, and problem solving.…

  20. From Professional Development to System Change: Teacher Leadership and Innovation

    ERIC Educational Resources Information Center

    Frost, David

    2012-01-01

    This article argues for a particular conceptualisation of teacher leadership; one that enables us to overcome the limitations of established approaches to continuing professional development as a strategy for school improvement by mobilising the massive untapped potential of teachers as leaders of innovation. In this article, teacher leadership is…

  1. Building America Top Innovations 2012: Advanced Framing Systems and Packages

    SciTech Connect

    none,

    2013-01-01

    This Building America Top Innovations profile describes Building America research showing advanced 2x6, 24-inch on-center framing, single top plates, open headers, and 2-stud corners reduced board feet of lumber by more than 1,000 feet, cut energy use by 13%, and cut material and labor costs by more than $1,000 on a typical home.

  2. Demonstration of Innovative Sewer System Inspection Technology SewerBatt

    EPA Science Inventory

    The overall objective of this EPA-funded study was to demonstrate innovative a sewer line assessment technology that is designed for rapid deployment using portable equipment. This study focused on demonstration of a technology that is suitable for smaller diameter pipes (less th...

  3. Demonstration of Innovative Sewer System Inspection Technology: SL-RAT

    EPA Science Inventory

    The overall objective of this EPA-funded study was to demonstrate innovative sewer line assessment technologies that are designed for rapid deployment using portable equipment. This study focused on demonstration of technologies that are suitable for smaller diameter pipes (less ...

  4. Organizational Agility and Complex Enterprise System Innovations: A Mixed Methods Study of the Effects of Enterprise Systems on Organizational Agility

    ERIC Educational Resources Information Center

    Kharabe, Amol T.

    2012-01-01

    Over the last two decades, firms have operated in "increasingly" accelerated "high-velocity" dynamic markets, which require them to become "agile." During the same time frame, firms have increasingly deployed complex enterprise systems--large-scale packaged software "innovations" that integrate and automate…

  5. Future Research in Agile Systems Development: Applying Open Innovation Principles Within the Agile Organisation

    NASA Astrophysics Data System (ADS)

    Conboy, Kieran; Morgan, Lorraine

    A particular strength of agile approaches is that they move away from ‘introverted' development and intimately involve the customer in all areas of development, supposedly leading to the development of a more innovative and hence more valuable information system. However, we argue that a single customer representative is too narrow a focus to adopt and that involvement of stakeholders beyond the software development itself is still often quite weak and in some cases non-existent. In response, we argue that current thinking regarding innovation in agile development needs to be extended to include multiple stakeholders outside the business unit. This paper explores the intra-organisational applicability and implications of open innovation in agile systems development. Additionally, it argues for a different perspective of project management that includes collaboration and knowledge-sharing with other business units, customers, partners, and other relevant stakeholders pertinent to the business success of an organisation, thus embracing open innovation principles.

  6. Open Innovation and the Erosion of the Traditional Information Systems Project's Boundaries

    NASA Astrophysics Data System (ADS)

    Elbanna, Amany

    This paper examines the notion of open innovation and its implication on information systems management. It investigates a project of an enterprise resource planning system implementation in an international organization to unravel the resemblance with the open innovation model. The study shows that the conceptualization of ERP project as an open innovation could reveal the complex architecture of today's organization from which the ERP project cannot be isolated. It argues that the traditional boundaries around IS projects are dissolving and the relationship between what used to be outside and what used to be inside the project is increasingly blurred. The study calls for a different perspective of project management that goes beyond single and multiple project management to scan the open space of innovation and actively look for partners, competitors, and collaborators.

  7. Corresponding Angle Feedback in an innovative weighted transportation system

    NASA Astrophysics Data System (ADS)

    Dong, Chuanfei; Ma, Xu

    2010-05-01

    The optimal information feedback has a significant effect on many socioeconomic systems like stock market and traffic systems aiming to make full use of resources. In this Letter, we study dynamics of traffic flow with real-time information. The influence of a feedback strategy named Corresponding Angle Feedback Strategy (CAFS) is introduced, based on a two-route scenario in which dynamic information can be generated and displayed on the board to guide road users to make a choice. Our model incorporates the effects of adaptability into the cellular automaton models of traffic flow and simulation results adopting this optimal information feedback strategy have demonstrated high efficiency in controlling spatial distribution of traffic patterns compared with the other three information feedback strategies, i.e., vehicle number and flux.

  8. Spacelabs Innovative Project Award winner--2007. Solar system of safety.

    PubMed

    Plouffe, Jannell A

    2010-01-01

    In 2004, the pediatric intensive unit at the Winnipeg Children's Hospital began a journey into space, engaging in the evolving culture of safety emerging in Canada. This process started with the joining of the Canadian ICU Collaborative on Patient Safety, where the first project focused on decreasing catheter-related blood stream infections (CRBSIs). This single project created the impetus for the mission: 2007 Solar system of safety. The solar system analogy was a powerful methodology to engage staff to travel to the different planets (projects) and step outside of their comfort zone into what some perceived as zero gravity. Planets (projects), in addition to CRBSIs, included safety huddles, safety newsletter, ventilator-associated pneumonia reduction, pediatric rapid response team, and executive walk rounds.

  9. Spacelabs Innovative Project Award winner--2007. Solar system of safety.

    PubMed

    Plouffe, Jannell A

    2010-01-01

    In 2004, the pediatric intensive unit at the Winnipeg Children's Hospital began a journey into space, engaging in the evolving culture of safety emerging in Canada. This process started with the joining of the Canadian ICU Collaborative on Patient Safety, where the first project focused on decreasing catheter-related blood stream infections (CRBSIs). This single project created the impetus for the mission: 2007 Solar system of safety. The solar system analogy was a powerful methodology to engage staff to travel to the different planets (projects) and step outside of their comfort zone into what some perceived as zero gravity. Planets (projects), in addition to CRBSIs, included safety huddles, safety newsletter, ventilator-associated pneumonia reduction, pediatric rapid response team, and executive walk rounds. PMID:20836419

  10. Integrated power system brings innovation to naval ship designs

    SciTech Connect

    Spotts, T.E.

    1997-07-01

    The development of an integrated power system (IPS) with lower life-cycle costs for the U.S. Navy is outlined in this article. The IPS combines electric propulsion, DC ship service distribution, and power management. Integrating ship service and propulsion power reduces the ship operating costs and improves overall life-cycle cost; generation capacity is controlled to closely match actual load requirements. The IPS design, ship arrangement studies, and land based evaluation are described in some detail in the article.

  11. Interpenetrating Polymer Networks as Innovative Drug Delivery Systems

    PubMed Central

    Lohani, Alka; Singh, Garima; Bhattacharya, Shiv Sankar; Verma, Anurag

    2014-01-01

    Polymers have always been valuable excipients in conventional dosage forms, also have shown excellent performance into the parenteral arena, and are now capable of offering advanced and sophisticated functions such as controlled drug release and drug targeting. Advances in polymer science have led to the development of several novel drug delivery systems. Interpenetrating polymer networks (IPNs) have shown superior performances over the conventional individual polymers and, consequently, the ranges of applications have grown rapidly for such class of materials. The advanced properties of IPNs like swelling capacity, stability, biocompatibility, nontoxicity and biodegradability have attracted considerable attention in pharmaceutical field especially in delivering bioactive molecules to the target site. In the past few years various research reports on the IPN based delivery systems showed that these carriers have emerged as a novel carrier in controlled drug delivery. The present review encompasses IPNs, their types, method of synthesis, factors which affects the morphology of IPNs, extensively studied IPN based drug delivery systems, and some natural polymers widely used for IPNs. PMID:24949205

  12. Interpenetrating polymer networks as innovative drug delivery systems.

    PubMed

    Lohani, Alka; Singh, Garima; Bhattacharya, Shiv Sankar; Verma, Anurag

    2014-01-01

    Polymers have always been valuable excipients in conventional dosage forms, also have shown excellent performance into the parenteral arena, and are now capable of offering advanced and sophisticated functions such as controlled drug release and drug targeting. Advances in polymer science have led to the development of several novel drug delivery systems. Interpenetrating polymer networks (IPNs) have shown superior performances over the conventional individual polymers and, consequently, the ranges of applications have grown rapidly for such class of materials. The advanced properties of IPNs like swelling capacity, stability, biocompatibility, nontoxicity and biodegradability have attracted considerable attention in pharmaceutical field especially in delivering bioactive molecules to the target site. In the past few years various research reports on the IPN based delivery systems showed that these carriers have emerged as a novel carrier in controlled drug delivery. The present review encompasses IPNs, their types, method of synthesis, factors which affects the morphology of IPNs, extensively studied IPN based drug delivery systems, and some natural polymers widely used for IPNs.

  13. Innovative Camera and Image Processing System to Characterize Cryospheric Changes

    NASA Astrophysics Data System (ADS)

    Schenk, A.; Csatho, B. M.; Nagarajan, S.

    2010-12-01

    The polar regions play an important role in Earth’s climatic and geodynamic systems. Digital photogrammetric mapping provides a means for monitoring the dramatic changes observed in the polar regions during the past decades. High-resolution, photogrammetrically processed digital aerial imagery provides complementary information to surface measurements obtained by laser altimetry systems. While laser points accurately sample the ice surface, stereo images allow for the mapping of features, such as crevasses, flow bands, shear margins, moraines, leads, and different types of sea ice. Tracking features in repeat images produces a dense velocity vector field that can either serve as validation for interferometrically derived surface velocities or it constitutes a stand-alone product. A multi-modal, photogrammetric platform consists of one or more high-resolution, commercial color cameras, GPS and inertial navigation system as well as optional laser scanner. Such a system, using a Canon EOS-1DS Mark II camera, was first flown on the Icebridge missions Fall 2009 and Spring 2010, capturing hundreds of thousands of images at a frame rate of about one second. While digital images and videos have been used for quite some time for visual inspection, precise 3D measurements with low cost, commercial cameras require special photogrammetric treatment that only became available recently. Calibrating the multi-camera imaging system and geo-referencing the images are absolute prerequisites for all subsequent applications. Commercial cameras are inherently non-metric, that is, their sensor model is only approximately known. Since these cameras are not as rugged as photogrammetric cameras, the interior orientation also changes, due to temperature and pressure changes and aircraft vibration, resulting in large errors in 3D measurements. It is therefore necessary to calibrate the cameras frequently, at least whenever the system is newly installed. Geo-referencing the images is

  14. Reforming America's health system through innovation and entrepreneurship.

    PubMed

    Reece, Richard L

    2005-01-01

    America's attempts for healthcare reform are gridlocked. Healthcare special interests are reluctant to abandon profitable activities, and American culture-distrust of centralized federal power, belief in self-improvement, desire for choice, and belief in equal access to medical technologies-is slow to change. Physician entrepreneurship and innovation, coupled with consumer-driven healthcare and public-private partnerships, may break the present gridlock.

  15. Wireless remote radiation monitoring system (WRRMS). Innovative technology summary report

    SciTech Connect

    Not Available

    1998-12-01

    The Science Application International Corporation (SAIC) RadStar{trademark} wireless remote radiation monitoring system (WRRMS) is designed to provide real-time monitoring of the radiation dose to workers as they perform work in radiologically contaminated areas. WRRMS can also monitor dose rates in a room or area. The system uses radio-frequency communications to transmit dose readings from the wireless dosimeters worn by workers to a remote monitoring station that can be located out of the contaminated area. Each base station can monitor up to 16 workers simultaneously. The WRRMS can be preset to trigger both audible and visual alarms at certain dose rates. The alarms are provided to the worker as well as the base station operator. This system is particularly useful when workers are wearing personal protective clothing or respirators that make visual observation of their self-reading dosimeters (SRDs), which are typically used to monitor workers, more difficult. The base station is an IBM-compatible personal computer that updates and records information on individual workers every ten seconds. Although the equipment costs for this improved technology are higher than the SRDs (amortized at $2.54/hr versus $1.02/hr), total operational costs are actually less ($639/day versus $851/day). This is because the WRRMS requires fewer workers to be in the contaminated zone than the traditional (baseline) technology. There are also intangible benefits associated with improved worker safety and as low as reasonably achievable (ALARA) principles, making the WRRMS an attractive alternative to the baseline technology. The baseline technology measures only integrated dose and requires workers to check their own dosimeters manually during the task.

  16. Innovative method for the thermal cycling of large spacecraft systems

    NASA Technical Reports Server (NTRS)

    Steimer, C. H.; Hale, A. D.

    1984-01-01

    The use of low cost, off the shelf prefabricated enclosures for spacecraft system thermal cycling applications was indicated. The enclosures are erected in the satellite integration areas without disturbing the test article, electrical test set, or RF interfaces. They are assembled by metal clad, modular urethane panels. These panels are self supporting, and are locked and sealed to each other on assembly. Penetrations for interconnecting cables, coaxial and waveguide services; and temperature conditioning inlet and outlet ducts are easily incorporated where required. The facility and its advantages and intrinsic benefits are described.

  17. [Casalud: innovations for the transformation of health systems].

    PubMed

    Tapia-Conyer, Roberto; Gallardo-Rincón, Héctor; Saucedo-Martínez, Rodrigo

    2012-01-01

    The increasing prevalence of non-communicable diseases (NCDs) has impacted the health systems by demanding unbearable costs of care and diminishing people's quality of life. The Instituto Carlos Slim de la Salud, a non-profit organization, has developed the model Casalud to convene partnerships with state governments to establish a reengineering process of primary care clinics, improving the delivery of services and leveraging on the different technological platforms to connect them with the households. The model Casalud strengthens the delivery of services and increases the timely demand of care. It is actually implemented in seven states seeking a progressive scale-up. PMID:23254716

  18. Innovative Use of a Classroom Response System During Physics Lab

    NASA Astrophysics Data System (ADS)

    Walgren, Jay

    2011-01-01

    More and more physics instructors are making use of personal/classroom response systems or "clickers." The use of clickers to engage students with multiple-choice questions during lecture and available instructor resources for clickers have been well documented in this journal.1-4 Newer-generation clickers, which I refer to as classroom response systems (CRS), have evolved to accept numeric answers (such as 9.81) instead of just single "multiple-choice" entries (Fig. 1). This advancement is available from most major clicker companies and allows for a greater variety of engaging questions during lecture. In addition, these new "numeric ready" clickers are marketed to be used for student assessments. During a test or quiz, students' answers are entered into their clicker instead of on paper or Scantron® and immediately absorbed by wireless connection into a computer for grading and analysis. I recognize the usefulness and benefit these new-generation CRSs provide for many instructors. However, I do not use my CRS in either of the aforementioned activities. Instead, I use it in an unconventional way. I use the CRS to electronically capture students' lab data as they are performing a physics lab (Fig. 2). I set up the clickers as if I were going to use them for a test, but instead of entering answers to a test, my students enter lab data as they collect it. In this paper I discuss my use of a classroom response system during physics laboratory and three benefits that result: 1) Students are encouraged to "take ownership of" and "have integrity with" their physics lab data. 2) Students' measuring and unit conversion deficiencies are identified immediately during the lab. 3) The process of grading students' labs is simplified because the results of each student's lab calculations can be pre-calculated for the instructor using a spreadsheet. My use of clickers during lab can be implemented with most clicker systems available to instructors today. The CRS I use is the e

  19. Innovative grassland management systems for environmental and livelihood benefits

    PubMed Central

    Kemp, David R.; Guodong, Han; Xiangyang, Hou; Michalk, David L.; Fujiang, Hou; Jianping, Wu; Yingjun, Zhang

    2013-01-01

    Grasslands occupy 40% of the world’s land surface (excluding Antarctica and Greenland) and support diverse groups, from traditional extensive nomadic to intense livestock-production systems. Population pressures mean that many of these grasslands are in a degraded state, particularly in less-productive areas of developing countries, affecting not only productivity but also vital environmental services such as hydrology, biodiversity, and carbon cycles; livestock condition is often poor and household incomes are at or below poverty levels. The challenge is to optimize management practices that result in “win-win” outcomes for grasslands, the environment, and households. A case study is discussed from northwestern China, where it has been possible to reduce animal numbers considerably by using an energy-balance/market-based approach while improving household incomes, providing conditions within which grassland recovery is possible. This bottom-up approach was supported by informing and working with the six layers of government in China to build appropriate policies. Further policy implications are considered. Additional gains in grassland rehabilitation could be fostered through targeted environmental payment schemes. Other aspects of the livestock production system that can be modified are discussed. This work built a strategy that has implications for many other grassland areas around the world where common problems apply. PMID:23671092

  20. Innovative grassland management systems for environmental and livelihood benefits.

    PubMed

    Kemp, David R; Guodong, Han; Xiangyang, Hou; Michalk, David L; Fujiang, Hou; Jianping, Wu; Yingjun, Zhang

    2013-05-21

    Grasslands occupy 40% of the world's land surface (excluding Antarctica and Greenland) and support diverse groups, from traditional extensive nomadic to intense livestock-production systems. Population pressures mean that many of these grasslands are in a degraded state, particularly in less-productive areas of developing countries, affecting not only productivity but also vital environmental services such as hydrology, biodiversity, and carbon cycles; livestock condition is often poor and household incomes are at or below poverty levels. The challenge is to optimize management practices that result in "win-win" outcomes for grasslands, the environment, and households. A case study is discussed from northwestern China, where it has been possible to reduce animal numbers considerably by using an energy-balance/market-based approach while improving household incomes, providing conditions within which grassland recovery is possible. This bottom-up approach was supported by informing and working with the six layers of government in China to build appropriate policies. Further policy implications are considered. Additional gains in grassland rehabilitation could be fostered through targeted environmental payment schemes. Other aspects of the livestock production system that can be modified are discussed. This work built a strategy that has implications for many other grassland areas around the world where common problems apply. PMID:23671092

  1. A Policy Framework for Health Systems to Promote Triple Aim Innovation.

    PubMed

    Verma, Amol; Bhatia, Sacha

    2016-01-01

    With the expiry of the Health Accords, provincial governments must face the challenge of improving performance in the context of ageing demographics, increasing multi-morbidity, and real concerns about financial stability. The Institute for Healthcare Improvement Triple Aim articulates fundamental goals that can guide health system transformation: improved population health, enhanced patient experience and reduced or stable per capita costs. Advancing fragmented and costly health systems in pursuit of these goals requires transformative, as opposed to iterative, change. Provincial governments are ideally suited to lead this change by acting as "integrators" who link healthcare organizations and align incentives across the spectrum of delivery. Although there is very limited evidence regarding the effectiveness of system-level reforms, we draw on initiatives from around the world to suggest policies that can promote system-level Triple Aim innovation. We categorize these policies within the classic functions ascribed to health systems: financing, stewardship and resource generation. As healthcare financers, governments should orient procurement policy towards the Triple Aim innovation and reform payment to reward value not volume. As health system stewards, governments should define a Triple Aim vision; measure and report outcomes, patient experience, and costs; integrate across sectors; and facilitate learning from failure and spread of successful innovation. As resource generators, governments should invest in health information technology to exploit "big data" and ensure that professional education equips front-line clinicians with skills necessary to improve systems. There are a number of barriers to system-level Triple Aim innovation. There is a lack of evidence for macro-level policy changes, innovation is costly and complicated, and system reform may not be politically appealing. Triple Aim innovation may also be conflated with organization-level quality

  2. A Policy Framework for Health Systems to Promote Triple Aim Innovation.

    PubMed

    Verma, Amol; Bhatia, Sacha

    2016-01-01

    With the expiry of the Health Accords, provincial governments must face the challenge of improving performance in the context of ageing demographics, increasing multi-morbidity, and real concerns about financial stability. The Institute for Healthcare Improvement Triple Aim articulates fundamental goals that can guide health system transformation: improved population health, enhanced patient experience and reduced or stable per capita costs. Advancing fragmented and costly health systems in pursuit of these goals requires transformative, as opposed to iterative, change. Provincial governments are ideally suited to lead this change by acting as "integrators" who link healthcare organizations and align incentives across the spectrum of delivery. Although there is very limited evidence regarding the effectiveness of system-level reforms, we draw on initiatives from around the world to suggest policies that can promote system-level Triple Aim innovation. We categorize these policies within the classic functions ascribed to health systems: financing, stewardship and resource generation. As healthcare financers, governments should orient procurement policy towards the Triple Aim innovation and reform payment to reward value not volume. As health system stewards, governments should define a Triple Aim vision; measure and report outcomes, patient experience, and costs; integrate across sectors; and facilitate learning from failure and spread of successful innovation. As resource generators, governments should invest in health information technology to exploit "big data" and ensure that professional education equips front-line clinicians with skills necessary to improve systems. There are a number of barriers to system-level Triple Aim innovation. There is a lack of evidence for macro-level policy changes, innovation is costly and complicated, and system reform may not be politically appealing. Triple Aim innovation may also be conflated with organization-level quality

  3. Unsteady jet in designing innovative drug delivery system

    NASA Astrophysics Data System (ADS)

    Wang, Cong; Mazur, Paul; Cosse, Julia; Rider, Stephanie; Gharib, Morteza

    2014-11-01

    Micro-needle injections, a promising pain-free drug delivery method, is constrained by its limited penetration depth. This deficiency can be overcome by implementing fast unsteady jet that can penetrate sub-dermally. The development of a faster liquid jet would increase the penetration depth and delivery volume of micro-needles. In this preliminary work, the nonlinear transient behavior of an elastic tube balloon in providing fast discharge is analyzed. A physical model that combines the Mooney Rivlin Material model and Young-Lapalce's Law was developed and used to investigate the fast discharging dynamic phenomenon. A proof of concept prototype was constructed to demonstrate the feasibility of a simple thumb-sized delivery system to generate liquid jet with desired speed in the range of 5-10 m/s. This work is supported by ZCUBE Corporation.

  4. Final Report: Technical Support for Innovative Energy Systems the U.S. Chemical Industry -- Innovative Energy Systems Pilot Project - Chemicals Project Integrator

    SciTech Connect

    John Cuttica - Principal Investigator; Dr Steffen Mueller - Lead Engineer

    2008-10-30

    The University of Illinois at Chicago Energy Resources Center (UIC/ERC) was originally selected to carry out the role of project integrator for a planned solicitation calling for proposals for innovative concepts for energy efficient systems in the chemical industry. The selection was made as a result of a DOE Announcement of Funding Opportunity issued by the DOE Golden Field Office. The U.S. DOE, due to funding constraints, decided to change the role of project integrator into one of technical support to DOE and the Vision 2020 Steering Committee in carrying out the oversight and management of the projects selected from the planned innovative concepts solicitation. This project, initiated in April, 2005, was established to provide that technical support to the U.S. DOE Innovative Energy Systems Pilot Project for the US Chemical Industry. In the late summer of 2006, and as a continuation of the baseline technology analysis conducted by UIC/ERC under this project, DOE requested that UIC/ERC assist in the development of “technology briefs” in support of the DOE Save Energy Now program. The 100 technology briefs developed under this contract were utilized by the Energy Experts as part of their Energy Saving Assessments (ESA).

  5. Remote Underwater Characterization System - Innovative Technology Summary Report

    SciTech Connect

    Willis, W D

    1999-04-01

    Characterization and inspection of water-cooled and moderated nuclear reactors and fuel storage pools requires equipment capable of operating underwater. Similarly, the deactivation and decommissioning of older nuclear facilities often requires the facility owner to accurately characterize underwater structures and equipment which may have been sitting idle for years. The Remote Underwater Characterization System (RUCS) is a small, remotely operated submersible vehicle intended to serve multiple purposes in underwater nuclear operations. It is based on the commercially-available "Scallop" vehicle 1 , but has been modified by the Department of Energy's Robotics Technology Development Program to add auto-depth control, and vehicle orientation and depth monitoring at the operator control panel. The RUCS is designed to provide visual and gamma radiation characterization, even in confined or limited access areas. It was demonstrated in August 1998 at the Idaho National Engineering and Environmental Laboratory (INEEL) as part of the INEEL Large Scale Demonstration and Deployment Project. During the demonstration it was compared in a "head-to-head" fashion with the baseline characterization technology. This paper summarizes the results of the demonstration and lessons learned; comparing and contrasting both technologies in the areas of cost, visual characterization, radiological characterization, and overall operations.

  6. Mixed microprocessor-random logic approach for innovative pacing systems.

    PubMed

    Gaggini, G; Garberoglio, B; Silvestri, L

    1992-11-01

    Modern pacing systems are becoming more and more sophisticated. Conversion of the information supplied by a sensor into suitable parameters for a rate controlling algorithm and the management of complex timing are common tasks for an integrated circuit (IC) in cardiac pacing. An effective solution consists of using a microprocessor to implement algorithms and pacing modes in a flexible way. The key point of using the same hardware resources for different tasks on a time sharing basis allows the design of a less complex IC when compared to a random logic structure with the same performances. The major design problems in a full microprocessor solution are its relatively low operating speed due to the low frequency clock necessary for low current drain, and the sequential structure of the machine itself. This can lead to unacceptable timing inaccuracy in all situations requiring the management of complex decision trees. In order to take full benefit from the advantages of a microprocessor structure without these drawbacks, a mixed microprocessor-random logic approach has been investigated. This architecture uses a microprocessor core to perform all high level nonreal-time operations (setup of the pacing cycle, data reduction and processing, data integrity checks) while a set of random logic peripherals is used for all critical timing aspects.

  7. Innovative Ballasted Flat Roof Solar PV Racking System

    SciTech Connect

    Peek, Richard T.

    2015-01-23

    The objective of this project was to reduce the cost of racking for PV solar on flat commercial rooftops. Cost reductions would come from both labor savings and material savings related to the installation process. The rack would need to accommodate the majority of modules available on the market. Cascade Engineering has a long history of converting traditional metal type applications over to plastic. Injection molding of plastics have numerous advantages including selection of resin for the application, placing the material exactly where it is needed, designing in features that will speed up the installation process, and weight reduction of the array. A plastic rack would need to meet the requirements of UL2703, Mounting systems, mounting devices, clamping/retention devices, and ground lugs for use with flat-plate photovoltaic modules and panels. Comparing original data to the end of project racking design, racking material costs were reduced 50% and labor costs reduced 64%. The racking product accommodates all 60 and 72 cell panels on the market, meets UL2703 requirements, contributes only 1.3 pounds per square foot of weight to the array, requires little ballast to secure the array, automatically grounds the module when the module is secured, stacks/nests well for shipping/fewer lifts to the roof, provides integrated wire routing, allows water to drain on the roof, and accommodates various seismic roof connections. Project goals were achieved as noted in the original funding application.

  8. 3D gel printing for soft-matter systems innovation

    NASA Astrophysics Data System (ADS)

    Furukawa, Hidemitsu; Kawakami, Masaru; Gong, Jin; Makino, Masato; Kabir, M. Hasnat; Saito, Azusa

    2015-04-01

    In the past decade, several high-strength gels have been developed, especially from Japan. These gels are expected to use as a kind of new engineering materials in the fields of industry and medical as substitutes to polyester fibers, which are materials of artificial blood vessels. We consider if various gel materials including such high-strength gels are 3D-printable, many new soft and wet systems will be developed since the most intricate shape gels can be printed regardless of the quite softness and brittleness of gels. Recently we have tried to develop an optical 3D gel printer to realize the free-form formation of gel materials. We named this apparatus Easy Realizer of Soft and Wet Industrial Materials (SWIM-ER). The SWIM-ER will be applied to print bespoke artificial organs, including artificial blood vessels, which will be possibly used for both surgery trainings and actual surgery. The SWIM-ER can print one of the world strongest gels, called Double-Network (DN) gels, by using UV irradiation through an optical fiber. Now we also are developing another type of 3D gel printer for foods, named E-Chef. We believe these new 3D gel printers will broaden the applications of soft-matter gels.

  9. Innovative coke oven gas cleaning system for retrofit applications

    SciTech Connect

    Not Available

    1992-10-16

    Bethlehem Steel Corporation (BSC), in conjunction with the Department of Energy (DOE) is conducting a Clean Coal Technology (CCT) project at its Sparrows Point, Maryland Coke Oven Plant. This project combines several existing technologies into an integrated system for removing impurities from Coke Oven Gas (COG) to make it an acceptable fuel. DOE is providing cost-sharing under a Cooperative Agreement with BSC. This Cooperative Agreement requires BSC to develop and conduct an Environmental Monitoring Plan (EMP) for the Clean Coal Technology project and to report the status of the EMP on a quarterly basis. This report is the third quarterly status report of the EMP. It covers the Environmental Monitoring Plan activities for the full year of 1991 from January 1, 1991 through December 31, 1991, including the forth quarter. See Sections 2, 3 and 4 for status reports of the Project Installation and Commissioning, the Environmental Monitoring activities and the Compliance Monitoring results for the period. Section 5 contains a list of Compliance Reports submitted to regulatory agencies during the period. The EMP describes in detail the environmental monitoring activities to be performed during the project execution. The purpose of the EMP is to: (1) document the extent of compliance of monitoring activities, i.e. those monitoring required to meet permit requirements, (2) confirm the specific impacts predicted in the National Environmental Policy Act documentation, and (3) establish an information base for the assessment of the environmental performance of the technology demonstrated by the project.

  10. Personal Ice Cooling System (PICS). Innovative technology summary report

    SciTech Connect

    1998-11-01

    The United States Department of Energy (DOE) continually seeks safer and more cost-effective remediation technologies for use in the decontamination and decommissioning (D and D) of nuclear facilities. To this end, the Deactivation and Decommissioning Focus Area (DDFA) of the DOE`s Office of Science and Technology sponsors Large-Scale Demonstration and Deployment Projects (LSDDPs) in which developers and vendors of improved or innovative technologies showcase products that are potentially beneficial to the DOE`s projects and to others in the D and D community. Benefits sought include decreased health and safety risks to personnel and the environment, increased productivity, and decreased cost of operation. As buildings are demolished as part of the DOE Fernald Environmental Management Project`s (FEMP`s) D and D Plan, many of the activities are performed in hot weather and usually require use of various types and layers of personal protective equipment (PPE). While PPE is designed to protect the worker from contamination, it also significantly compromises the body`s ability to cool itself, leading to potentially serious heat stress situations. This report describes a comparative demonstration between the methodology currently used for heat stress management (i.e., limited stay times and cool-down rooms) and an alternative personal ice cooling suit technology. The baseline methodology for heat stress management is limited stay times when working in hot conditions. The FEMP`s Safety Performance Requirements outline the procedures and stay times to be followed and consider the temperature of the working environment, work load, and the type and amount of PPE required for the job. While these common criteria for determining stay times, other sites may have different requirements. This demonstration investigates the feasibility of using the personal ice cooling suite as a tool for managing heat stress in workers at the FEMP. This report provides a comparative analysis of

  11. Proven Innovations and New Initiatives in Ground System Development: Reducing Costs in the Ground System

    NASA Technical Reports Server (NTRS)

    Gunn, Jody M.

    2006-01-01

    The state-of-the-practice for engineering and development of Ground Systems has evolved significantly over the past half decade. Missions that challenge ground system developers with significantly reduced budgets in spite of requirements for greater and previously unimagined functionality are now the norm. Making the right trades early in the mission lifecycle is one of the key factors to minimizing ground system costs. The Mission Operations Strategic Leadership Team at the Jet Propulsion Laboratory has spent the last year collecting and working through successes and failures in ground systems for application to future missions.

  12. Remote Underwater Characterization System - Innovative Technology Summary Report

    SciTech Connect

    Willis, Walter David

    1999-04-01

    Characterization and inspection of water-cooled and moderated nuclear reactors and fuel storage pools requires equipment capable of operating underwater. Similarly, the deactivation and decommissioning of older nuclear facilities often requires the facility owner to accurately characterize underwater structures and equipment which may have been sitting idle for years. The underwater characterization equipment is often required to operate at depths exceeding 20 ft (6.1 m) and in relatively confined or congested spaces. The typical baseline approach has been the use of radiation detectors and underwater cameras mounted on long poles, or stationary cameras with pan and tilt features mounted on the sides of the underwater facility. There is a perceived need for an inexpensive, more mobile method of performing close-up inspection and radiation measurements in confined spaces underwater. The Remote Underwater Characterization System (RUCS) is a small, remotely operated submersible vehicle intended to serve multiple purposes in underwater nuclear operations. It is based on the commercially-available “Scallop” vehicle1, but has been modified by Department of Energy’s Robotics Technology Development Program to add auto-depth control, and vehicle orientation and depth monitoring at the operator control panel. The RUCS is designed to provide visual and gamma radiation characterization, even in confined or limited access areas. It was demonstrated in August 1998 at Idaho National Engineering and environmental Laboratory (INEEL) as part of the INEEL Large Scale Demonstration and Deployment Project. During the demonstration it was compared in a “head-tohead” fashion with the baseline characterization technology. This paper summarizes the results of the demonstration and lessons learned; comparing and contrasting both technologies in the areas of cost, visual characterization, radiological characterization, and overall operations.

  13. Democracy and environment as references for quadruple and quintuple helix innovation systems

    NASA Astrophysics Data System (ADS)

    Carayannis, Elias G.; Campbell, David F. J.; Orr, Barron J.

    2015-04-01

    The perspective of democracy and the ecological context define key references for knowledge production and innovation in innovation systems. Particularly under conditions of environmental change where enhancing the potential for adaptation is critical, this requires a closer look at ecological responsibility and sensitivity in the different innovation models and governance regimes. The "Quintuple Helix" innovation model is an approach that stresses the necessary socio-ecological transition of society and economy by adding an environment helix to an innovation system already made up of three (university-industry-government) or four (civil society relations) helices in a way that supports adaptation by incorporating global warming as both a challenge to and a driver of innovation. There is the proposition that knowledge production and innovation co-evolve with democracy (Carayannis and Campbell, 2014). In the Triple Helix model (Etzkowitz and Leydesdorff, 2000) the existence of a democracy does not appear to be necessary for knowledge production and innovation. However, the Quadruple Helix (Carayannis and Campbell, 2009, 2010 and 2014) is defined and represented by additional key attributes and components: "media-based and culture-based public", "civil society" and "arts, artistic research and arts-based innovation" (Bast, Carayannis and Campbell, 2015). Implications of this are that the fourth helix in the Quadruple Helix innovation systems brings in and represents the perspective of "dimension of democracy" or the "context of democracy" for knowledge in general and knowledge production and innovation in more particular. Within theories of democracy there is a competition between narrow and broader concepts of democracy (Campbell, 2013). This is particularly true when democracy is to be understood to transcend more substantially the narrow understanding of being primarily based on or being primarily rooted in government institutions (within a Triple Helix

  14. Research on Innovative Practice Teaching System Based on the High-End Practice Teaching Environment for Software Engineering Speciality

    NASA Astrophysics Data System (ADS)

    Dong, Jianli; Li, Cunhua; Ji, Zhaohui; Wu, Junming

    Through the analysis of current culture status of undergraduate engineering applied talents, the paper points out that the main reason causing the lack of student integrated application and practice innovation abilities is the poor construction of high-end practice environment. And then, how to enhance the practice environment construction and practical teaching innovation as well as building an appropriate innovation practice teaching system for engineering applied talents are systematically discussed. It is very obvious that the application and promotion of this kind of innovative practice teaching system could enhance the practice innovation abilities and entrepreneurial and employment awareness of the graduates.

  15. Professional Learning Communities and the Diffusion of Pedagogical Innovation in the Chinese Education System

    ERIC Educational Resources Information Center

    Sargent, Tanja Carmel

    2015-01-01

    Pedagogical innovations have been diffusing unevenly through the Chinese education system as a result of the implementation of the New Curriculum Reforms. Drawing on large-scale linked teacher and principal survey data from the Gansu Survey of Children and Families, this article investigates the extent to which interlocking teacher networks, which…

  16. [Scientific evidence and the cost of innovations in the health-care system].

    PubMed

    Porzsolt, Franz; Schreyögg, Jonas

    2009-08-01

    When depicting the relationship between evidence and the cost of an innovation in the health-care system, the overall risks of assessment, the redistribution of risks in a regulated market, and the ethical consequences must first be taken into account. There are also evidence-based criteria and economic considerations which are relevant when calculating the cost of an innovation. These topics can indicate, but not exhaustively deal with the complicated relationship between scientific evidence and calculating the cost of an innovation in the health-care system. The following three statements summarize the current considerations in the continuing discussion of this topic: *Scientific evidence undoubtedly exists which should be taken into consideration when calculating the cost of an innovation in the health-care system. *The existing scientific evidence is, however, not sufficient to reach such a decision. Additional information about the benefit perceived by the patient is required. *No standardized method exists to measure this additional information. Therefore, a definition problem also exists in the health-care system when setting a price according to scientific evidence.

  17. The System of Management of Innovation Projects at a Higher Education

    ERIC Educational Resources Information Center

    Kalimullin, Aydar M.; Youngblood, Valery ?.; Khodyreva, Elana A.

    2016-01-01

    The urgency of the issue discussed in this article is caused by the need for development and assessment of new models and mechanisms of management of higher education institutions, which are connected with the development of the system of management of innovation projects and contribute to the development of educational institutions. The aim of…

  18. EVALUATION OF REAL-TIME INNOVATIVE BIOLOGICAL AND CHEMICAL MONITORING SYSTEMS TO PROTECT SOURCE WATERS

    EPA Science Inventory

    Evaluation of Real-Time Innovative Biological and Chemical Monitoring Systems
    To Protect Source Waters

    Drinking water supplies have in recent years come under increasing pressure from regulatory concerns regarding TMDL designations and restoration strategies as well ...

  19. The Changing Face of South Africa's National System of Innovation, 1991?2001

    ERIC Educational Resources Information Center

    Kahn, Michael; Blankley, William

    2005-01-01

    The article examines changes in the South African national system of innovation (NSI) since the onset of democracy in 1994. In particular, the recently completed 2001/02 Survey of Research and Experimental Development (R&D) is used to quantify the shifts in R&D activity for the major business, government and higher education players. The major…

  20. Agricultural Extension, Collective Action and Innovation Systems: Lessons on Network Brokering from Peru and Mexico

    ERIC Educational Resources Information Center

    Hellin, Jon

    2012-01-01

    Purpose: New approaches to extension service delivery are needed that stimulate increased agricultural production, contribute to collective action and which also foster the emergence of agricultural innovation systems. Research in Peru and Mexico explores some of these new approaches. Design/methodology/approach: In both countries, a qualitative…

  1. Evaluation of an Innovative Sand Filter for Small System Drinking Water Treatment

    EPA Science Inventory

    Results of evaluation of an innovative sand filter that uses the concepts of both slow and rapid sand filtration are presented in this article. The system uses a low-cost “Drum Sand Filter” (DSF) that consists of a 55-gallon drum filled with layers of sand of varying size. A low-...

  2. Knowledge Production within the Innovation System: A Case Study from the United Kingdom

    ERIC Educational Resources Information Center

    Wilson-Medhurst, Sarah

    2010-01-01

    This paper focuses on a key issue for university managers, educational developers and teaching practitioners: that of producing new operational knowledge in the innovation system. More specifically, it explores the knowledge required to guide individual and institutional styles of teaching and learning in a large multi-disciplinary faculty. The…

  3. Which Advisory System to Support Innovation in Conservation Agriculture? The Case of Madagascar's Lake Alaotra

    ERIC Educational Resources Information Center

    Faure, Guy; Penot, Eric; Rakotondravelo, Jean Chrysostome; Ramahatoraka, Haja Andrisoa; Dugue, Patrick; Toillier, Aurelie

    2013-01-01

    Purpose: To promote sustainable agriculture, various development projects are encouraging farmers around Madagascar's Lake Alaotra to adopt conservation agriculture techniques. This article's objective is to analyze the capacity of a project-funded advisory system to accompany such an innovation and to design and implement an advisory method aimed…

  4. The PLATO System: A Study in the Diffusion of an Innovation.

    ERIC Educational Resources Information Center

    Driscoll, Francis D.; Wolf, W. C., Jr.

    This study was designed to ascertain the relationships between the steps of a tool designed to link knowledge production and the needs of knowledge users (the Wolf-Welsh Linkage Methodology or WWLM) with milestones in the evolution of an innovative computer-assisted instructional system called PLATO (Programming Logic for Advanced Teaching…

  5. Knowledge Management Systems and Open Innovation in Second Tier UK Universities

    ERIC Educational Resources Information Center

    Chaston, Ian

    2012-01-01

    The purpose of this paper is to examine the performance of second tier UK universities in relation to the effectiveness of their knowledge management systems and involvement in open innovation. Data were acquired using a mail survey of academic staff in social science and business faculties in second tier institutions. The results indicate that…

  6. Opportunities for nursing innovation in a changing health care system: a case analysis.

    PubMed

    Scott, J G

    1996-01-01

    Opportunities for nursing leadership and innovation have emerged as a result of the reorganization of health systems. A case study illustrates such opportunities, with reference to the related literature of health care redesign. The creation of a new department and a new role for nursing as a response to current market forces are presented as an exemplar in organizational redesign and nursing leadership.

  7. ROCHEM SEPARATION SYSTEMS, INC. DISC TUBE™ MODULE TECHNOLOGY - INNOVATIVE TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    SITE program demonstration of the Rochem Disc Tube™ Module (DTM) developed by Rochem Separation systems Inc. The demonstration test was conducted at the central landfill Superfund site in Johnston, Rhode Island in August 1994. The DTM technology is an innovative membrane filtra...

  8. Accessibility Is the Mother of Invention: When It Comes to an Innovative Hand Control System

    ERIC Educational Resources Information Center

    Exceptional Parent, 2007

    2007-01-01

    This article features Sure Grip hand control, an innovative hand control system created by Keith Howell, the President and founder of Howell Ventures LTD. Howell was in his early teens when he experienced an accident that resulted in his quadriplegia. From that point on, Howell set about to manufacture a set of controls that would emulate the…

  9. An Innovative Ceramic Corrosion Protection System for Zircaloy Cladding

    SciTech Connect

    Ronald H. Baney, Dr. D. Butt, Dr. P. Demkowicz, Dr. G. Fuchs Department of Materials Science; James S. Tulenko, Department of Nuclear and Radiological Engineering; University of Florida.

    2003-02-19

    Light Water reactor (LWR) fuel performance is currently limited by thermal, chemical and mechanical constraints associated with the design, fabrication, and operation of the fuel in incore operation. Corrosion of the zirconium based (Zircaloy-4) alloy cladding of the fuel is a primary limiting factor. Recent success at the University of Florida in developing thin ceramic films with great adhesive properties for metal substrates offers an innovative breakthrough for eliminating a major weakness of the Zircaloy clad. ?The University of Florida proposes to coat the existing Zircaloy clad tubes with a ceramic coating for corrosion protection. An added bonus of this approach would be the implementation of a boron-containing burnable poison outer layer will also be demonstrated as part of the ceramic coating development. In this proposed effort, emphasis will be on the ceramic coating with only demonstration of feasibility on the burnable outer coating approach. This proposed program i s expected to give a step change (approximately a doubling) in clad lifetime before failure due to corrosion. In the development of ceramic coatings for Zircaloy-4 clad, silicon carbide and zirconium carbide coatings will first be applied to Zircaloy-4 coupons and cladding samples by thermal assisted chemical vapor deposition, plasma assisted chemical vapor deposition or by laser ablation deposition. All of these processes are in use at the University of Florida and have shown great potential. The questions of adhesion and thermal expansion mismatch of the ceramic coating to the Zircaloy substrate will be addressed. Several solutions to these conditions will be examined, if needed. These solutions include the use of a zirconium oxide compliant layer, employment of a laser roughened surface and the use of a gradient composition interlayer. These solutions have already been shown to be effective for other high modulus coatings on metal substrates. Mechanical properties and adhesion of the

  10. The Advanced Exploration Systems Water Recovery Project: Innovation on 2 Fronts

    NASA Technical Reports Server (NTRS)

    Sarguisingh, Miriam M.; Neumeyer, Derek; Shull, Sarah

    2012-01-01

    As NASA looks forward to sending humans farther away from Earth, we will have to develop a transportation architecture that is highly reliable and that can sustain life for long durations without the benefit of Earth s proximity for continuous resupply or even operational guidance. NASA has consistently been challenged with performing great feats of innovation, but particularly in this time of economic stress, we are challenged to go farther with less. The Advanced Exploration Systems (AES) projects were implemented to address both of these needs by not only developing innovative technologies, but by incorporating innovative management styles and processes that foster the needed technical innovation given a small amount of resources. This presentation explains how the AES Water Recovery Project is exhibiting innovation on both fronts; technical and process. The AES Water Recovery Project (WRP) is actively engineering innovative technologies in order to maximize the efficiency of water recovery. The development of reliable, energy-efficient, and low-mass spacecraft systems to provide environmental control and life support (ECLS) is critical to enable long-duration human missions outside of low-Earth orbit. Recycling of life support consumables is necessary to reduce resupply mass and provide for vehicle autonomy. To address this, the WRP is working on a rotary distiller that has shown enhanced performance over the state-of-the-art (SOA). Additionally, the WRP is looking at innovative ways to address issues present in the state-of-the-art (SOA) systems pertaining to toxicity and calcium scale buildup. As an AES project, the WRP has a more streamlined Skunk Works like approach to technology development intended to reduce overhead but achieve a more refined end product. The project has incorporated key partnerships between NASA centers as well as between NASA and industry. A minimal project management style has been implemented such that risks are managed and

  11. Terra-Preta-Technology as an innovative system component to create circulation oriented, sustainable land use systems

    NASA Astrophysics Data System (ADS)

    Dotterweich, M.; Böttcher, J.; Krieger, A.

    2012-04-01

    This paper presents current research and application projects on innovative system solutions which are based on the implementation of a regional resource efficient material flow management as well as utilising "Terra-Preta-Technology" as an innovative system component. Terra Preta Substrate (TPS) is a recently developed substance composed of liquid and solid organic matter, including biochar, altered by acid-lactic fermentation. Based on their properties, positive effects on water and nutrient retention, soil microbiological activity, and cation-exchange capacity are expected and currently investigated by different projects. TPS further sequesters carbon and decreases NO2 emissions from fertilized soils as observed by the use of biochar. The production of TPS is based on a circulation oriented organic waste management system directly adapted to the local available inputs and desired soil amendment properties. The production of TPS is possible with simple box systems for subsistence farming but also on a much larger scale as modular industrial plants for farmers or commercial and municipal waste management companies in sizes from 500 and 50,000 m3. The Terra-Preta-Technology enhances solutions to soil conservation, soil amelioration, humic formation, reduced water consumption, long term carbon sequestration, nutrient retention, containment binding, and to biodiversity on local to a regional scale. The projects also involve research of ancient land management systems to enhance resource efficiency by means of an integrative and transdisciplinary approach.

  12. A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm

    SciTech Connect

    Aderem, Alan; Adkins, Joshua N.; Ansong, Charles; Galagan, James; Kaiser, Shari; Korth, Marcus J.; Law, G. L.; McDermott, Jason E.; Proll, Sean; Rosenberger, Carrie; Schoolnik, Gary; Katze, Michael G.

    2011-02-01

    The 20th century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and water borne illnesses are frequent, multi-drug resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the 21st century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program we think that the time is at hand to redefine the pathogen-host research paradigm.

  13. Biopharmaceutical Innovation System and the Influence of Policies:The Case of Taiwan (2000-2008)

    PubMed Central

    Chung, Chao Chen

    2013-01-01

    This article discusses the influence of policies on the development of biopharmaceuticals. We choose the experiences of Taiwan for our empirical study and focus on the evolution between 2000 and 2008; in the period of time the country provides an interesting example for further exploration of biopharmaceutical policies. Among all the policies, the two National Programs (National Research Program for Genetic Medicine and National Science and Technology Program for Biotechnology and Pharmaceuticals) and the Law of Pharmaceutical Affairs showed the contrasting effects on the innovation system of biopharmaceuticals. As a result, the government generated very limited positive influence on the innovation of biopharmaceuticals. PMID:24596851

  14. Biopharmaceutical innovation system and the influence of policies:the case of taiwan (2000-2008).

    PubMed

    Chung, Chao Chen

    2013-08-01

    This article discusses the influence of policies on the development of biopharmaceuticals. We choose the experiences of Taiwan for our empirical study and focus on the evolution between 2000 and 2008; in the period of time the country provides an interesting example for further exploration of biopharmaceutical policies. Among all the policies, the two National Programs (National Research Program for Genetic Medicine and National Science and Technology Program for Biotechnology and Pharmaceuticals) and the Law of Pharmaceutical Affairs showed the contrasting effects on the innovation system of biopharmaceuticals. As a result, the government generated very limited positive influence on the innovation of biopharmaceuticals. PMID:24596851

  15. Innovative-Simplified Nuclear Power Plant Efficiency Evaluation with High-Efficiency Steam Injector System

    SciTech Connect

    Shoji, Goto; Shuichi, Ohmori; Michitsugu, Mori

    2006-07-01

    It is possible to establish simplified system with reduced space and total equipment weight using high-efficiency Steam Injectors (SI) instead of low-pressure feedwater heaters in Nuclear Power Plant (NPP). The SI works as a heat exchanger through direct contact between feedwater from condensers and extracted steam from turbines. It can get higher pressure than supplied steam pressure. The maintenance and reliability are still higher than the feedwater ones because SI has no movable parts. This paper describes the analysis of the heat balance, plant efficiency and the operation of this Innovative-Simplified NPP with high-efficiency SI. The plant efficiency and operation are compared with the electric power of 1100 MWe-class BWR system and the Innovative-Simplified BWR system with SI. The SI model is adapted into the heat balance simulator with a simplified model. The results show that plant efficiencies of the Innovated-Simplified BWR system are almost equal to original BWR ones. The present research is one of the projects that are carried out by Tokyo Electric Power Company, Toshiba Corporation, and six Universities in Japan, funded from the Institute of Applied Energy (IAE) of Japan as the national public research-funded program. (authors)

  16. Implementing for Sustainability: Promoting Use of a Measurement Feedback System for Innovation and Quality Improvement.

    PubMed

    Douglas, Susan; Button, Suzanne; Casey, Susan E

    2016-05-01

    Measurement feedback systems (MFSs) are increasingly recognized as evidence-based treatments for improving mental health outcomes, in addition to being a useful administrative tool for service planning and reporting. Promising research findings have driven practice administrators and policymakers to emphasize the incorporation of outcomes monitoring into electronic health systems. To promote MFS integrity and protect against potentially negative outcomes, it is vital that adoption and implementation be guided by scientifically rigorous yet practical principles. In this point of view, the authors discuss and provide examples of three user-centered and theory-based principles: emphasizing integration with clinical values and workflow, promoting administrative leadership with the 'golden thread' of data-informed decision-making, and facilitating sustainability by encouraging innovation. In our experience, enacting these principles serves to promote sustainable implementation of MFSs in the community while also allowing innovation to occur, which can inform improvements to guide future MFS research.

  17. Innovative optical power detection array system for relative positioning of inner-formation flying system

    NASA Astrophysics Data System (ADS)

    Hou, Zhendong; Wang, Zhaokui; Zhang, Yulin

    2016-09-01

    The Inner-formation flying system (IFFS) is conceived to feature a spherical proof mass falling freely within a large cavity for space gravity detection, of which first application focuses on the Earth's gravity field recovery. For the IFFS, it is the relative position of the proof mass to its surrounding cavity that is feedback into thrusters for tracking control, even as part of data to detect gravity. Since the demonstration and verification of demanding technologies using small satellite platforms is a very sensible choice prior to detection mission, an optical power detection array system (OPDAS) is proposed to measure the relative position with advantages of low cost and high adaptability. Besides that, its large dynamic range can reduce the requirement for satellite platform and releasing mechanism, which is also an attracting trait for small satellite application. The concept of the OPDAS is firstly presented, followed by the algorithm to position the proof mass. Then the radiation pressure caused by the measuring beam is modeled, and its disturbance on the proof mass is simulated. The experimental system to test the performance of a prototype of the OPDAS is established, and the preliminary results show that a precision of less than 0.4 mm across a dynamic range of several centimeters can be reached by the prototype of the OPDAS.

  18. Quantitative wound healing measurement and monitoring system based on an innovative 3D imaging system

    NASA Astrophysics Data System (ADS)

    Yi, Steven; Yang, Arthur; Yin, Gongjie; Wen, James

    2011-03-01

    In this paper, we report a novel three-dimensional (3D) wound imaging system (hardware and software) under development at Technest Inc. System design is aimed to perform accurate 3D measurement and modeling of a wound and track its healing status over time. Accurate measurement and tracking of wound healing enables physicians to assess, document, improve, and individualize the treatment plan given to each wound patient. In current wound care practices, physicians often visually inspect or roughly measure the wound to evaluate the healing status. This is not an optimal practice since human vision lacks precision and consistency. In addition, quantifying slow or subtle changes through perception is very difficult. As a result, an instrument that quantifies both skin color and geometric shape variations would be particularly useful in helping clinicians to assess healing status and judge the effect of hyperemia, hematoma, local inflammation, secondary infection, and tissue necrosis. Once fully developed, our 3D imaging system will have several unique advantages over traditional methods for monitoring wound care: (a) Non-contact measurement; (b) Fast and easy to use; (c) up to 50 micron measurement accuracy; (d) 2D/3D Quantitative measurements;(e) A handheld device; and (f) Reasonable cost (< $1,000).

  19. Analysing stratified medicine business models and value systems: innovation-regulation interactions.

    PubMed

    Mittra, James; Tait, Joyce

    2012-09-15

    Stratified medicine offers both opportunities and challenges to the conventional business models that drive pharmaceutical R&D. Given the increasingly unsustainable blockbuster model of drug development, due in part to maturing product pipelines, alongside increasing demands from regulators, healthcare providers and patients for higher standards of safety, efficacy and cost-effectiveness of new therapies, stratified medicine promises a range of benefits to pharmaceutical and diagnostic firms as well as healthcare providers and patients. However, the transition from 'blockbusters' to what might now be termed 'niche-busters' will require the adoption of new, innovative business models, the identification of different and perhaps novel types of value along the R&D pathway, and a smarter approach to regulation to facilitate innovation in this area. In this paper we apply the Innogen Centre's interdisciplinary ALSIS methodology, which we have developed for the analysis of life science innovation systems in contexts where the value creation process is lengthy, expensive and highly uncertain, to this emerging field of stratified medicine. In doing so, we consider the complex collaboration, timing, coordination and regulatory interactions that shape business models, value chains and value systems relevant to stratified medicine. More specifically, we explore in some depth two convergence models for co-development of a therapy and diagnostic before market authorisation, highlighting the regulatory requirements and policy initiatives within the broader value system environment that have a key role in determining the probable success and sustainability of these models.

  20. The Emergence and Challenging Growth of the Bio-Ethanol Innovation System in Taiwan (1949-2015).

    PubMed

    Chung, Chao-Chen; Yang, Siang-Cing

    2016-02-19

    This study explores the bio-ethanol innovation system in Taiwan from the perspective of a technology innovation system (TIS). Taiwan is a newly industrialized country and is not currently a main producer of bio-ethanol. This study analyzes the evolution of bio-ethanol innovation system in Taiwan and places a particular emphasis on challenges that present policies face in the context of potential long-term bio-ethanol development. Through an evaluation of the consistency of the present research, technology, development and innovation (RTDI) policies as well as the influence of these policies on the functional dynamics of bio-ethanol innovation system, mechanisms prohibiting the system from flourishing are determined. It is suggested that the production of bio-ethanol in Taiwan would be achieved if the government: (1) fixes long-term targets for both domestic bio-ethanol development and emission reduction; and (2) comprehensively designs a set of interrelated RTDI policies in accordance with the functional pattern of the bio-ethanol innovation system and consistently implements these policies. If such measures were implemented, it is considered that the bio-ethanol innovation system in Taiwan would flourish.

  1. The Emergence and Challenging Growth of the Bio-Ethanol Innovation System in Taiwan (1949–2015)

    PubMed Central

    Chung, Chao-Chen; Yang, Siang-Cing

    2016-01-01

    This study explores the bio-ethanol innovation system in Taiwan from the perspective of a technology innovation system (TIS). Taiwan is a newly industrialized country and is not currently a main producer of bio-ethanol. This study analyzes the evolution of bio-ethanol innovation system in Taiwan and places a particular emphasis on challenges that present policies face in the context of potential long-term bio-ethanol development. Through an evaluation of the consistency of the present research, technology, development and innovation (RTDI) policies as well as the influence of these policies on the functional dynamics of bio-ethanol innovation system, mechanisms prohibiting the system from flourishing are determined. It is suggested that the production of bio-ethanol in Taiwan would be achieved if the government: (1) fixes long-term targets for both domestic bio-ethanol development and emission reduction; and (2) comprehensively designs a set of interrelated RTDI policies in accordance with the functional pattern of the bio-ethanol innovation system and consistently implements these policies. If such measures were implemented, it is considered that the bio-ethanol innovation system in Taiwan would flourish. PMID:26907306

  2. An innovative artificial recharge system to enhance groundwater storage in basaltic terrain: example from Maharashtra, India

    NASA Astrophysics Data System (ADS)

    Bhusari, Vijay; Katpatal, Y. B.; Kundal, Pradeep

    2016-08-01

    The management of groundwater poses challenges in basaltic terrain as its availability is not uniform due to the absence of primary porosity. Indiscriminate excessive withdrawal from shallow as well as deep aquifers for meeting increased demand can be higher than natural recharge, causing imbalance in demand and supply and leading to a scarcity condition. An innovative artificial recharge system has been conceived and implemented to augment the groundwater sources at the villages of Saoli and Sastabad in Wardha district of Maharashtra, India. The scheme involves resectioning of a stream bed to achieve a reverse gradient, building a subsurface dam to arrest subsurface flow, and installation of recharge shafts to recharge the deeper aquifers. The paper focuses on analysis of hydrogeological parameters like porosity, specific yield and transmissivity, and on temporal groundwater status. Results indicate that after the construction of the artificial recharge system, a rise of 0.8-2.8 m was recorded in the pre- and post-monsoon groundwater levels in 12 dug wells in the study area; an increase in the yield was also noticed which solved the drinking water and irrigation problems. Spatial analysis was performed using a geographic information system to demarcate the area of influence of the recharge system due to increase in yields of the wells. The study demonstrates efficacy, technical viability and applicability of an innovative artificial recharge system constructed in an area of basaltic terrain prone to water scarcity.

  3. Adapting the design of Anesthesia Information Management Systems to innovations depicted in Industrial Property documents.

    PubMed

    Spyropoulos, B; Tzavaras, A; Zogogianni, D; Botsivaly, M

    2013-01-01

    The purpose of this paper is to present the design and the current development status of an Anesthesia Information Management System (AIMS). For this system, the physical and technical advances, depicted in relevant, recently published Industrial Property documents, have been taken into account. Additional innovative sensors create further data-load to be managed. Novel wireless data-transmission modes demand eventually compliance to further proper standards, so that interoperability between AIMS and the existing Hospital Information Systems is being sustained. We attempted to define, the state-of-the-art concerning the functions, the design-prerequisites and the relevant standards and of an "emerging" AIMS that is combining hardware innovation, real-time data acquisition, processing and displaying and lastly enabling the necessary interoperability with the other components of the existing Hospital Information Systems. Finally, we report based on this approach, about the design and implementation status, of our "real-world" system under development and discuss the multifarious obstacles encountered during this still on-going project.

  4. Farming system design for innovative crop-livestock integration in Europe.

    PubMed

    Moraine, M; Duru, M; Nicholas, P; Leterme, P; Therond, O

    2014-08-01

    The development of integrated crop-livestock systems (ICLS) is a major challenge for the ecological modernisation of agriculture but appears difficult to implement at a large scale. A participatory method for ICLS design has been developed and implemented in 15 case studies across Europe, representing a range of production systems, challenges, constraints and resources for innovation. Local stakeholders, primarily farmers, but also cooperatives, environmental-association representatives and natural-resource managers, were involved in the identification of challenges and existing initiatives of crop-livestock integration; in the design of new options at field, farm and territory levels; and then in qualitative multicriteria assessment of these options. A conceptual framework based on a conceptual model (crops, grasslands, animals) was developed to act as a boundary object in the design step and invite innovative thinking in 'metabolic' and 'ecosystemic' approaches. A diversity of crops and grasslands interacting with animals appeared central for designing sustainable farming systems at the territory level, providing and benefitting from ecosystem services. Within this diversity, we define three types of integrated systems according to their degrees of spatial and temporal coordination: complementarity, local synergy, territorial synergy. Moreover, the options for cooperation and collective organisation between farmers and other stakeholders in territories to organise and manage this diversity of land use revealed opportunities for smart social innovation. The qualitative multicriteria assessment identified farmer workload as the main issue of concern while demonstrating expected benefits of ICLS simultaneously for economic, agronomic, environmental and social criteria. This study concludes that participatory design of ICLS based on a generic multi-level and multi-domain framework and a methodology to deal with a local context can identify new systems to be tested

  5. An innovative integrated system utilizing solar energy as power for the treatment of decentralized wastewater.

    PubMed

    Han, Changfu; Liu, Junxin; Liang, Hanwen; Guo, Xuesong; Li, Lin

    2013-02-01

    This article reports an innovative integrated system utilizing solar energy as power for decentralized wastewater treatment, which consists of an oxidation ditch with double channels and a photovoltaic (PV) system without a storage battery. Because the system operates without a storage battery, which can reduce the cost of the PV system, the solar radiation intensity affects the amount of power output from the PV system. To ensure that the power output is sufficient in all different weather conditions, the solar radiation intensity of 78 W/m2 with 95% confidence interval was defined as a threshold of power output for the PV system according to the monitoring results in this study, and a step power output mode was used to utilize the solar energy as well as possible. The oxidation ditch driven by the PV system without storage battery ran during the day and stopped at night. Therefore, anaerobic, anoxic and aerobic conditions could periodically appear in the oxidation ditch, which was favorable to nitrogen and phosphate removal from the wastewater. The experimental results showed that the system was efficient, achieving average removal efficiencies of 88% COD, 98% NH4+-N, 70% TN and 83% TP, under the loading rates of 140 mg COD/(g MLSS x day), 32 mg NH4+-N/(g MLSS x day), 44 mg TN/(g MLSS x day) and 5 mg TP/(g MLSS x day).

  6. Organisational reporting and learning systems: Innovating inside and outside of the box

    PubMed Central

    Furniss, Dominic

    2015-01-01

    Reporting and learning systems are key organisational tools for the management and prevention of clinical risk. However, current approaches, such as incident reporting, are struggling to meet expectations of turning health systems like the UK National Health Service (NHS) into learning organisations. This article aims to open up debate on the potential for novel reporting and learning systems in healthcare, by reflecting on experiences from two recent projects: Proactive Risk Monitoring in Healthcare (PRIMO) and Errordiary in Healthcare. These two approaches demonstrate how paying attention to ordinary, everyday clinical work can derive useful learning and active discussion about clinical risk. We argue that innovations in reporting and learning systems might come from both inside and outside of the box. ‘Inside’ being along traditional paths of controlled organisational innovation. ‘Outside’ in the sense that inspiration comes outside of the healthcare domain, or more extremely, outside official channels through external websites and social media (e.g. patient forums, public review sites, whistleblower blogs and Twitter streams). Reporting routes that bypass official channels could empower staff and patient activism, and turn out to be a driver to challenge organisational processes, assumptions and priorities where the organisation is failing and has become unresponsive. PMID:25999777

  7. Using MERRA Gridded Innovations for Quantifying Uncertainties in Analysis Fields and Diagnosing Observing System Inhomogeneities

    NASA Technical Reports Server (NTRS)

    da Silva, Arlindo; Redder, Christopher

    2010-01-01

    MERRA is a NASA reanalysis for the satellite era using a major new version of the Goddard Earth Observing System Data Assimilation System Version 5 (GEOS-5). The project focuses on historical analyses of the hydrological cycle on a broad range of weather and climate time scales and places the NASA EOS suite of observations in a climate context. The characterization of uncertainty in reanalysis fields is a commonly requested feature by users of such data. While intercomparison with reference data sets is common practice for ascertaining the realism of the datasets, such studies typically are restricted to long term climatological statistics and seldom provide state dependent measures of the uncertainties involved. In principle, variational data assimilation algorithms have the ability of producing error estimates for the analysis variables (typically surface pressure, winds, temperature, moisture and ozone) consistent with the assumed background and observation error statistics. However, these "perceived error estimates" are expensive to obtain and are limited by the somewhat simplistic errors assumed in the algorithm. The observation minus forecast residuals (innovations) by-product of any assimilation system constitutes a powerful tool for estimating the systematic and random errors in the analysis fields. Unfortunately, such data is usually not readily available with reanalysis products, often requiring the tedious decoding of large datasets and not so-user friendly file formats. With MERRA we have introduced a gridded version of the observations/innovations used in the assimilation process, using the same grid and data formats as the regular datasets. Such dataset empowers the user with the ability of conveniently performing observing system related analysis and error estimates. The scope of this dataset will be briefly described. We will present a systematic analysis of MERRA innovation time series for the conventional observing system, including maximum

  8. Antiviral Information Management System (AIMS): a prototype for operational innovation in drug development.

    PubMed

    Jadhav, Pravin R; Neal, Lauren; Florian, Jeff; Chen, Ying; Naeger, Lisa; Robertson, Sarah; Soon, Guoxing; Birnkrant, Debra

    2010-09-01

    This article presents a prototype for an operational innovation in knowledge management (KM). These operational innovations are geared toward managing knowledge efficiently and accessing all available information by embracing advances in bioinformatics and allied fields. The specific components of the proposed KM system are (1) a database to archive hepatitis C virus (HCV) treatment data in a structured format and retrieve information in a query-capable manner and (2) an automated analysis tool to inform trial design elements for HCV drug development. The proposed framework is intended to benefit drug development by increasing efficiency of dose selection and improving the consistency of advice from US Food and Drug Administration (FDA). It is also hoped that the framework will encourage collaboration among FDA, industry, and academic scientists to guide the HCV drug development process using model-based quantitative analysis techniques. PMID:20881217

  9. [Prospects of systemic radioecology in solving innovative tasks of nuclear power engineering].

    PubMed

    Spiridonov, S I

    2014-01-01

    A need of systemic radioecological studies in the strategy developed by the atomic industry in Russia in the XXI century has been justified. The priorities in the radioecology of nuclear power engineering of natural safety associated with the development of the radiation-migration equivalence concept, comparative evaluation of innovative nuclear technologies and forecasting methods of various emergencies have been identified. Also described is an algorithm for the integrated solution of these tasks that includes elaboration of methodological approaches, methods and software allowing dose burdens to humans and biota to be estimated. The rationale of using radioecological risks for the analysis of uncertainties in the environmental contamination impacts,at different stages of the existing and innovative nuclear fuel cycles is shown.

  10. Antiviral Information Management System (AIMS): a prototype for operational innovation in drug development.

    PubMed

    Jadhav, Pravin R; Neal, Lauren; Florian, Jeff; Chen, Ying; Naeger, Lisa; Robertson, Sarah; Soon, Guoxing; Birnkrant, Debra

    2010-09-01

    This article presents a prototype for an operational innovation in knowledge management (KM). These operational innovations are geared toward managing knowledge efficiently and accessing all available information by embracing advances in bioinformatics and allied fields. The specific components of the proposed KM system are (1) a database to archive hepatitis C virus (HCV) treatment data in a structured format and retrieve information in a query-capable manner and (2) an automated analysis tool to inform trial design elements for HCV drug development. The proposed framework is intended to benefit drug development by increasing efficiency of dose selection and improving the consistency of advice from US Food and Drug Administration (FDA). It is also hoped that the framework will encourage collaboration among FDA, industry, and academic scientists to guide the HCV drug development process using model-based quantitative analysis techniques.

  11. Relationship-Relevant and Family-Friendly eHealth: Innovations in Interactive Health Communication Systems

    PubMed Central

    ROBERTS, LINDA J.; JAPUNTICH, SANDRA

    2012-01-01

    As the reach of the Internet grows, eHealth is fast becoming a major adjunct to traditional delivery of health information and support worldwide. Existing Interactive health communication systems, however, typically target individual users, focus on individual rather than on relational health, and neglect the relational and familial context of individual health issues. Reviewing developments primarily in the United States, this article applies a “marriage and family lens” to examine web-based technologies for health and well-being and suggests innovations to make eHealth both relationship relevant and family friendly. Although recent innovations offer great promise for supporting the relational “fabric” of family life, specific cautions and the need for research on effectiveness are underscored. PMID:23144519

  12. The intrinsic features of Environmental Management Systems that facilitate adoption and encourage innovation in primary industries.

    PubMed

    Carruthers, Genevieve; Vanclay, Frank

    2012-11-15

    This paper examines the theoretical underpinnings of the adoption of innovations, and applies this knowledge to the uptake of Environmental Management Systems (EMS) amongst Australian farmers. We examine the specific features of the EMS process that might encourage or inhibit EMS adoption. We also consider elements of the EMS process to assess their utility in promoting adoption of various other innovations. We evaluate the EMS process in the light of two characteristics previously found to influence adoption of improved natural resource management practices - 'relative advantage' and 'trialability'. Drawing on literature, and our research and experience with farmers, we conclude that there are inherent features of EMS that promote the adoption of new practices, and that the elements of the EMS process actually create an on-going process of culture change as it is implemented. We believe that the EMS process offers significant advantages to farmers seeking to improve production whilst simultaneously meeting societal expectations for enhanced natural resource management. PMID:22776757

  13. An innovative approach to supplying an environment for the integration and test of the Space Station distributed avionics systems

    NASA Technical Reports Server (NTRS)

    Barry, Thomas; Scheffer, Terrance; Small, L. R.

    1988-01-01

    This paper describes an innovative approach to supplying an environment for the integration and testing of the Space Station distributed avionics systems. The environment's relationship to the process flow of the Space Station verification from systems development to on-orbit verification is presented. This paper also describes the uses of the environment's hardware implementation called Data Management System (DMS) kits. The way in which this environment allows system developers to independently verify their system's performance, fault detection, and recovery capability is explained.

  14. INNOVATIVE TECHNOLOGY VERIFICATION REPORT "FIELD MEASUREMENT TECHNOLOGIES FOR TOTAL PETROLEUM HYDROCARBONS IN SOIL" ENVIRONMENTAL SYSTEMS CORPORATION SYNCHRONOUS SCANNING LUMINOSCOPE

    EPA Science Inventory


    The Synchronous Scanning Luminoscope (Luminoscope) developed by the Oak Ridge National Laboratory in collaboration with Environmental Systems Corporation (ESC) was demonstrated under the U.S. Environmental Protection Agency Superfund Innovative Technology Evaluation Program i...

  15. Drug delivery system innovation and Health Technology Assessment: Upgrading from Clinical to Technological Assessment.

    PubMed

    Panzitta, Michele; Bruno, Giorgio; Giovagnoli, Stefano; Mendicino, Francesca R; Ricci, Maurizio

    2015-11-30

    Health Technology Assessment (HTA) is a multidisciplinary health political instrument that evaluates the consequences, mainly clinical and economical, of a health care technology; the HTA aim is to produce and spread information on scientific and technological innovation for health political decision making process. Drug delivery systems (DDS), such as nanocarriers, are technologically complex but they have pivotal relevance in therapeutic innovation. The HTA process, as commonly applied to conventional drug evaluation, should upgrade to a full pharmaceutical assessment, considering the DDS complexity. This is useful to study more in depth the clinical outcome and to broaden its critical assessment toward pharmaceutical issues affecting the patient and not measured by the current clinical evidence approach. We draw out the expertise necessary to perform the pharmaceutical assessment and we propose a format to evaluate the DDS technological topics such as formulation and mechanism of action, physicochemical characteristics, manufacturing process. We integrated the above-mentioned three points in the Evidence Based Medicine approach, which is data source for any HTA process. In this regard, the introduction of a Pharmaceutics Expert figure in the HTA could be fundamental to grant a more detailed evaluation of medicine product characteristics and performances and to help optimizing DDS features to overcome R&D drawbacks. Some aspects of product development, such as manufacturing processes, should be part of the HTA as innovative manufacturing processes allow new products to reach more effectively patient bedside. HTA so upgraded may encourage resource allocating payers to invest in innovative technologies and providers to focus on innovative material properties and manufacturing processes, thus contributing to bring more medicines in therapy in a sustainable manner.

  16. Drug delivery system innovation and Health Technology Assessment: Upgrading from Clinical to Technological Assessment.

    PubMed

    Panzitta, Michele; Bruno, Giorgio; Giovagnoli, Stefano; Mendicino, Francesca R; Ricci, Maurizio

    2015-11-30

    Health Technology Assessment (HTA) is a multidisciplinary health political instrument that evaluates the consequences, mainly clinical and economical, of a health care technology; the HTA aim is to produce and spread information on scientific and technological innovation for health political decision making process. Drug delivery systems (DDS), such as nanocarriers, are technologically complex but they have pivotal relevance in therapeutic innovation. The HTA process, as commonly applied to conventional drug evaluation, should upgrade to a full pharmaceutical assessment, considering the DDS complexity. This is useful to study more in depth the clinical outcome and to broaden its critical assessment toward pharmaceutical issues affecting the patient and not measured by the current clinical evidence approach. We draw out the expertise necessary to perform the pharmaceutical assessment and we propose a format to evaluate the DDS technological topics such as formulation and mechanism of action, physicochemical characteristics, manufacturing process. We integrated the above-mentioned three points in the Evidence Based Medicine approach, which is data source for any HTA process. In this regard, the introduction of a Pharmaceutics Expert figure in the HTA could be fundamental to grant a more detailed evaluation of medicine product characteristics and performances and to help optimizing DDS features to overcome R&D drawbacks. Some aspects of product development, such as manufacturing processes, should be part of the HTA as innovative manufacturing processes allow new products to reach more effectively patient bedside. HTA so upgraded may encourage resource allocating payers to invest in innovative technologies and providers to focus on innovative material properties and manufacturing processes, thus contributing to bring more medicines in therapy in a sustainable manner. PMID:26399633

  17. Improving System Integration: The Art and Science of Engaging Small Community Practices in Health System Innovation

    PubMed Central

    Pus, Laura; Stanaitis, Ian; Ivers, Noah; Baker, G. Ross; Lockhart, Elizabeth; Hawker, Gillian

    2016-01-01

    This paper focuses on successful engagement strategies in recruiting and retaining primary care physicians (PCPs) in a quality improvement project, as perceived by family physicians in small practices. Sustained physician engagement is critical for quality improvement (QI) aiming to enhance health system integration. Although there is ample literature on engaging physicians in hospital or team-based practice, few reports describe factors influencing engagement of community-based providers practicing with limited administrative support. The PCPs we describe participated in SCOPE: Seamless Care Optimizing the Patient Experience, a QI project designed to support their care of complex patients and reduce both emergency department (ED) visits and inpatient admissions. SCOPE outcome measures will inform subsequent papers. All the 30 participating PCPs completed surveys assessing perceptions regarding the importance of specific engagement strategies. Project team acknowledgement that primary care is challenging and new access to patient resources were the most important factors in generating initial interest in SCOPE. The opportunity to improve patient care via integration with other providers was most important in their commitment to participate, and a positive experience with project personnel was most important in their continued engagement. Our experience suggests that such providers respond well to personalized, repeated, and targeted engagement strategies. PMID:26904284

  18. Expanding the Role of an Earth Science Data System: The GHRC Innovations Lab

    NASA Astrophysics Data System (ADS)

    Conover, H.; Ramachandran, R.; Smith, T.; Kulkarni, A.; Maskey, M.; He, M.; Keiser, K.; Graves, S. J.

    2013-12-01

    The Global Hydrology Resource Center is a NASA Earth Science Distributed Active Archive Center (DAAC), managed in partnership by the Earth Science Department at NASA's Marshall Space Flight Center and the University of Alabama in Huntsville's Information Technology and Systems Center. Established in 1991, the GHRC processes, archives and distributes global lightning data from space, airborne and ground based observations from hurricane science field campaigns and Global Precipitation Mission (GPM) ground validation experiments, and satellite passive microwave products. GHRC's close association with the University provides a path for technology infusion from the research center into the data center. The ITSC has a long history of designing and operating science data and information systems. In addition to the GHRC and related data management projects, the ITSC also conducts multidisciplinary research in many facets of information technology. The coupling of ITSC research with the operational GHRC Data Center has enabled the development of new technologies that directly impact the ability of researchers worldwide to apply Earth science data to their specific domains of interest. The GHRC Innovations Lab will provide a showcase for emerging geoinformatics technologies resulting from NASA-sponsored research at the ITSC. Research products to be deployed in the Innovations Lab include: * Data Albums - curated collections of information related to a specific science topic or event with links to relevant data files from different sources. * Data Prospecting - combines automated data mining techniques with user interaction to provide for quick exploration of large volumes of data. * Provenance Browser - provides for graphical exploration of data lineage and related contextual information. In the Innovations Lab, these technologies can be targeted to GHRC data sets, and tuned to address GHRC user interests. As technologies are tested and matured in the Innovations Lab, the

  19. Proposal of an Innovative Electric Power Distribution System based on Packet Power Transactions

    NASA Astrophysics Data System (ADS)

    Inoue, Jun; Fujii, Yasumasa

    Recently, the introduction of decentralized generators, such as photovoltaic power generations, has been promoted rapidly. In the future, extensive use of PV is thought to give rise to the daytime surplus electricity, and a household will manage the surplus electricity rationally. The purpose of this research is to propose an innovative electric power distribution system based on packet power transactions. First, this paper explains distributed markets of which the price can easily reflect the geographical diversity of renewable energy availability and load curve characteristic within the local area. Second, this paper exemplifies the specific electronic circuit that makes pulse-shaped power transmission to develop the packet power distribution system. Finally, this paper shows the results of multi-agent simulations of electricity trading to evaluate the usefulness of the proposed system.

  20. Innovative Gamma Ray Spectrometer Detection Systems for Conducting Scanning Surveys on Challenging Terrain - 13583

    SciTech Connect

    Palladino, Carl; Mason, Bryan; Engle, Matt; LeVangie, James; Dempsey, Gregg; Klemovich, Ron

    2013-07-01

    The Santa Susana Field Laboratory located near Simi Valley, California was investigated to determine the nature and extent of gamma radiation anomalies. The primary objective was to conduct gamma scanning surveys over 100 percent of the approximately 1,906,000 square meters (471 acre) project site with the most sensitive detection system possible. The site had challenging topography that was not conducive to traditional gamma scanning detection systems. Terrain slope varied from horizontal to 48 degrees and the ground surface ranged from flat, grassy meadows to steep, rocky hillsides. In addition, the site was home to many protected endangered plant and animal species, and archaeologically significant sites that required minimal to no disturbance of the ground surface. Therefore, four innovative and unique gamma ray spectrometer detection systems were designed and constructed to successfully conduct gamma scanning surveys of approximately 1,076,000 square meters (266 acres) of the site. (authors)

  1. Performance evaluation of a full-scale innovative swine waste-to-energy system.

    PubMed

    Xu, Jiele; Adair, Charles W; Deshusses, Marc A

    2016-09-01

    Intensive monitoring was carried out to evaluate the performance of a full-scale innovative swine waste-to-energy system at a commercial swine farm with 8640 heads of swine. Detailed mass balances over each unit of the system showed that the system, which includes a 7600m(3) anaerobic digester, a 65-kW microturbine, and a 4200m(3) aeration basin, was able to remove up to 92% of the chemical oxygen demand (COD), 99% of the biological oxygen demand (BOD), 77% of the total nitrogen (TN), and 82% of the total phosphorous (TP) discharged into the system as fresh pig waste. The overall biogas yield based on the COD input was 64% of the maximum theoretical, a value that indicates that even greater environmental benefits could be obtained with process optimization. Overall, the characterization of the materials fluxes in the system provides a greater understanding of the fate of organics and nutrients in large scale animal waste management systems.

  2. Performance evaluation of a full-scale innovative swine waste-to-energy system.

    PubMed

    Xu, Jiele; Adair, Charles W; Deshusses, Marc A

    2016-09-01

    Intensive monitoring was carried out to evaluate the performance of a full-scale innovative swine waste-to-energy system at a commercial swine farm with 8640 heads of swine. Detailed mass balances over each unit of the system showed that the system, which includes a 7600m(3) anaerobic digester, a 65-kW microturbine, and a 4200m(3) aeration basin, was able to remove up to 92% of the chemical oxygen demand (COD), 99% of the biological oxygen demand (BOD), 77% of the total nitrogen (TN), and 82% of the total phosphorous (TP) discharged into the system as fresh pig waste. The overall biogas yield based on the COD input was 64% of the maximum theoretical, a value that indicates that even greater environmental benefits could be obtained with process optimization. Overall, the characterization of the materials fluxes in the system provides a greater understanding of the fate of organics and nutrients in large scale animal waste management systems. PMID:27268434

  3. Organizational Support Systems for Innovation and Intrapreneurship: A Comparative Analysis of Innovative Cases from R&D Centres and Operating Departments of Large Corporations

    ERIC Educational Resources Information Center

    Manimala, Mathew J.; Jose, P.D.; Thomas, K. Raju

    2007-01-01

    The research literature is rich on innovations in R&D-specific organizations and provides useful information on support systems and other organizational features associated with such specialized organizations. An implied assumption of many studies is that R&D exists as an independent entity, without controls or influences from the other functions…

  4. System of Indicators in the Innovation Management: Business Intelligence Applied to Tourism

    NASA Astrophysics Data System (ADS)

    Lozada, Dayana; Araque, Francisco; Castillo, Jose Manuel; Salguero, Alberto; Delgado, Cecilia; Noda, Marcia; Hernández, Gilberto

    The work presents an approach to study mechanisms that allows managers the Innovation Management (IM) measurements. It is assumed, as main motivation, the analysis of patterns for the design of an integral system of indicators. A methodology that integrates the thought process, focusing on the Business Intelligence and the Balance Scorecard will be presented. A group of indexes based on the multidimensionality of IM in organizations of the sector of tourism is proposed. To approach this quality it is necessary to contextualize, in the conditions of sectoral operation, the theories, models and systems used in our approach. It has been used intervention methods like experts' criteria, consensus search techniques by means of surveys, consultation of documents, and statistical methods such as analysis of the main components.

  5. An innovative system for 3D clinical photography in the resource-limited settings

    PubMed Central

    2014-01-01

    Background Kaposi’s sarcoma (KS) is the most frequently occurring cancer in Mozambique among men and the second most frequently occurring cancer among women. Effective therapeutic treatments for KS are poorly understood in this area. There is an unmet need to develop a simple but accurate tool for improved monitoring and diagnosis in a resource-limited setting. Standardized clinical photographs have been considered to be an essential part of the evaluation. Methods When a therapeutic response is achieved, nodular KS often exhibits a reduction of the thickness without a change in the base area of the lesion. To evaluate the vertical space along with other characters of a KS lesion, we have created an innovative imaging system with a consumer light-field camera attached to a miniature “photography studio” adaptor. The image file can be further processed by computational methods for quantification. Results With this novel imaging system, each high-quality 3D image was consistently obtained with a single camera shot at bedside by minimally trained personnel. After computational processing, all-focused photos and measurable 3D parameters were obtained. More than 80 KS image sets were processed in a semi-automated fashion. Conclusions In this proof-of-concept study, the feasibility to use a simple, low-cost and user-friendly system has been established for future clinical study to monitor KS therapeutic response. This 3D imaging system can be also applied to obtain standardized clinical photographs for other diseases. PMID:24929434

  6. Innovative enclosure dome/observing aperture system design for the MROI Array Telescopes

    NASA Astrophysics Data System (ADS)

    Busatta, A.; Marchiori, G.; Mian, S.; Payne, I.; Pozzobon, M.

    2010-07-01

    The close-pack array of the MROI necessitated an original design for the Unit Telescope Enclosure (UTE) at Magdalena Ridge Observatory. The Magdalena Ridge Observatory Interferometer (MROI) is a project which comprises an array of up to ten (10) 1.4m diameter mirror telescopes arranged in a "Y" configuration. Each of these telescopes will be housed inside a Unit Telescope Enclosure (UTE) which are relocatable onto any of 28 stations. The most compact configuration includes all ten telescopes, several of which are at a relative distance of less than 8m center to center from each other. Since the minimum angle of the field of regard is 30° with respect to the horizon, it is difficult to prevent optical blockage caused by adjacent UTEs in this compact array. This paper presents the design constraints inherent in meeting the requirement for the close-pack array. An innovative design enclosure was created which incorporates an unique dome/observing aperture system. The description of this system focuses on how the field of regard requirement led to an unique and highly innovative concept that had to be able to operate in the harsh environmental conditions encountered at an altitude of 10,460ft (3,188m). Finally, we describe the wide use of composites materials and structures (e.g. glass/carbon fibres, sandwich panels etc.) on the aperture system which represents the only way to guarantee adequate thermal and environmental protection, compactness, structural stability and limited power consumption due to reduced mass.

  7. The Relationship of School System Innovativeness to Selected Dimensions of Interpersonal Behavior in Eight School Systems. Report from the Models for Planned Educational Change Project. Technical Report No. 70.

    ERIC Educational Resources Information Center

    Hilfiker, Leo R.

    A study examined the relationship between school system innovativeness and selected dimensions of interpersonal behavior in eight Wisconsin school systems. A composite ranking of school system innovativeness was developed from three sources: the district superintendent, the professional staff of the system, and a State Department panel. Selected…

  8. Innovation Approaches to Development and Ground Testing of Advanced Bimodal Space Power and Propulsion Systems

    SciTech Connect

    Hill, T.; Noble, C.; Martinell, J.; Borowski, S.

    2000-07-14

    The last major development effort for nuclear power and propulsion systems ended in 1993. Currently, there is not an initiative at either the National Aeronautical and Space Administration (NASA) or the U.S. Department of Energy (DOE) that requires the development of new nuclear power and propulsion systems. Studies continue to show nuclear technology as a strong technical candidate to lead the way toward human exploration of adjacent planets or provide power for deep space missions, particularly a 15,000 lbf bimodal nuclear system with 115 kW power capability. The development of nuclear technology for space applications would require technology development in some areas and a major flight qualification program. The last major ground test facility considered for nuclear propulsion qualification was the U.S. Air Force/DOE Space Nuclear Thermal Propulsion Project. Seven years have passed since that effort, and the questions remain the same, how to qualify nuclear power and propulsion systems for future space flight. It can be reasonably assumed that much of the nuclear testing required to qualify a nuclear system for space application will be performed at DOE facilities as demonstrated by the Nuclear Rocket Engine Reactor Experiment (NERVA) and Space Nuclear Thermal Propulsion (SNTP) programs. The nuclear infrastructure to support testing in this country is aging and getting smaller, though facilities still exist to support many of the technology development needs. By renewing efforts, an innovative approach to qualifying these systems through the use of existing facilities either in the U.S. (DOE's Advance Test Reactor, High Flux Irradiation Facility and the Contained Test Facility) or overseas should be possible.

  9. Innovative Approaches to Development and Ground Testing of Advanced Bimodal Space Power and Propulsion Systems

    SciTech Connect

    Hill, Thomas Johnathan; Noble, Cheryl Ann; Noble, C.; Martinell, John Stephen; Borowski, S.

    2000-07-01

    The last major development effort for nuclear power and propulsion systems ended in 1993. Currently, there is not an initiative at either the National Aeronautical and Space Administration (NASA) or the U.S. Department of Energy (DOE) that requires the development of new nuclear power and propulsion systems. Studies continue to show nuclear technology as a strong technical candidate to lead the way toward human exploration of adjacent planets or provide power for deep space missions, particularly a 15,000 lbf bimodal nuclear system with 115 kW power capability. The development of nuclear technology for space applications would require technology development in some areas and a major flight qualification program. The last major ground test facility considered for nuclear propulsion qualification was the U.S. Air Force/DOE Space Nuclear Thermal Propulsion Project. Seven years have passed since that effort, and the questions remain the same, how to qualify nuclear power and propulsion systems for future space flight. It can be reasonable assumed that much of the nuclear testing required to qualify a nuclear system for space application will be performed at DOE facilities as demonstrated by the Nuclear Rocket Engine Reactor Experiment (NERVA) and Space Nuclear Thermal Propulsion (SNTP) programs. The nuclear infrastructure to support testing in this country is aging and getting smaller, though facilities still exist to support many of the technology development needs. By renewing efforts, an innovative approach to qualifying these systems through the use of existing facilities either in the U.S. (DOE's Advance Test Reactor, High Flux Irradiation Facility and the Contained Test Facility) or overseas should be possible.

  10. An Innovative Unmanned System for Advanced Environmental Monitoring: Design and Development

    NASA Astrophysics Data System (ADS)

    Marsella, Ennio; Giordano, Laura; Evangelista, Lorenza; Iengo, Antonio; di Filippo, Alessandro; Coppola, Aniello

    2015-04-01

    The paper summarizes the design and development of a new technology and tools for real-time coordination and control of unmanned vehicles for advanced environmental monitoring. A new Unmanned System has been developed at Institute for Coastal Marine Environmental - National Research Council (Italy), in the framework of two National Operational Programs (PON): Technological Platform for Geophysical and Environmental Marine Survey-PITAM and Integrated Systems and Technologies for Geophysical and Environmental Monitoring in coastal-marine areas-STIGEAC. In particular, the system includes one Unmanned Aerial Vehicle (UAV) and two Unmanned Marine Vehicles (UMV). Major innovations concern the implementation of a new architecture to control each drone and/or to allow the cooperation between heterogeneous vehicles, the integration of distributed sensing techniques and real-time image processing capabilities. Part of the research in these projects involves, therefore, an architecture, where the ground operator can communicate with the Unmanned Vehicles at various levels of abstraction using pointing devices and video viewing. In detail, a Ground Control Station (GCS) has been design and developed to allow the government in security of the drones within a distance up to twenty kilometers for air explorations and within ten nautical miles for marine activities. The Ground Control Station has the following features: 1. hardware / software system for the definition of the mission profiles; 3. autonomous and semi-autonomous control system by remote control (joystick or other) for the UAV and UMVs; 4. integrated control system with comprehensive visualization capabilities, monitoring and archiving of real-time data acquired from scientific payload; 5. open structure to future additions of systems, sensors and / or additional vehicles. In detail, the UAV architecture is a dual-rotor, with an endurance ranging from 55 to 200 minutes, depending on payload weight (maximum 26 kg) and

  11. Xenia: A Metaphor for Sense-Making and Acting in Information Systems Innovation

    NASA Astrophysics Data System (ADS)

    Higgins, Allen; Vidolov, Simeon; Frößler, Frank; Mullaney, Doreen

    This paper draws on Ciborra's insightful concept of xenia (i.e., hospitality) to analyze how successful infrastructural service innovation was managed at the local operations of an international financial services firm. The xenia concept problematizes the information system development (ISD) orthodoxy and points to issues and aspects that are often overlooked or considered irrelevant in structured methodologies. In interpreting the findings of the empirical study—in which a highly successful (but radical) big bang transition from one technology platform to another takes place over a single weekend—we suggest that IS implementation and development is an emergent process in which technology and users are continually redefined. This process resembles an emotional "meeting" between host and guest who, over time, develop mutual familiarity and acceptance. Further, we argue that the metaphor of xenia opens space for reconsidering conventional but socially sterile approaches to IS innovation; xenia offers a radically different way for understanding and acting upon ISD. Our analysis highlights the intrinsic socio-technical interplay underlying IS development and implementation, and raises questions about the importance of local cultures of "hospitality" and ways they may be cultivated and nurtured in order to alleviate the meeting between technology and organizations.

  12. An implementation of co-simulation for performance prediction of innovative integrated HVAC systems in buildings

    SciTech Connect

    Trcka, Marija; Wetter, Michael; Hensen, Jan L.M.

    2010-07-01

    Integrated performance simulation of buildings and heating, ventilation and air-conditioning (HVAC) systems can help reducing energy consumption and increasing level of occupant comfort. However, no singe building performance simulation (BPS) tool offers sufficient capabilities and flexibilities to accommodate the ever-increasing complexity and rapid innovations in building and system technologies. One way to alleviate this problem is to use co-simulation. The co-simulation approach represents a particular case of simulation scenario where at least two simulators solve coupled differential-algebraic systems of equations and exchange data that couples these equations during the time integration. This paper elaborates on issues important for co-simulation realization and discusses multiple possibilities to justify the particular approach implemented in a co-simulation prototype. The prototype is verified and validated against the results obtained from the traditional simulation approach. It is further used in a case study for the proof-of-concept, to demonstrate the applicability of the method and to highlight its benefits. Stability and accuracy of different coupling strategies are analyzed to give a guideline for the required coupling frequency. The paper concludes by defining requirements and recommendations for generic cosimulation implementations.

  13. Advanced Recyclable Media System{reg_sign}. Innovative technology summary report

    SciTech Connect

    1998-12-01

    The objective of the Large-Scale Demonstration Project (LSDP) is to select and demonstrate potentially beneficial technologies at the Argonne National Laboratory East`s (ANL) Chicago Pile-5 (CP-5) Research Reactor. The purpose of the LSDP is to demonstrate that using innovative and improved deactivation and decommissioning (D and D) technologies from various sources can result in significant benefits, such as decreased cost and increased health and safety, as compared with baseline D and D technologies. This report describes a demonstration of the Advanced Recyclable Media System{reg_sign} technology which was employed by Surface Technology Systems, Inc. to remove coatings from a concrete floor. This demonstration is part of the CP-5 LSDP sponsored by the US Department of Energy (DOE) Office of Science and Technology Deactivation and Decommissioning Focus Area (DDFA). The Advanced Recyclable Media System{reg_sign} (ARMS) technology is an open blast technology which uses a soft recyclable media. The patented ARMS Engineered Blast Media consists of a fiber-reinforced polymer matrix which can be manufactured in various grades of abrasiveness. The fiber media can be remade and/or reused up to 20 times and can clean almost any surface (e.g., metal, wood, concrete, lead) and geometry including corners and the inside of air ducts.

  14. Evaluation of primary stability of innovated orthodontic miniscrew system (STS): An ex-vivo study

    PubMed Central

    Seifi, Massoud

    2016-01-01

    Background Stability is determined as one of the requirements in use of Temporary Anchorage Devices (TAD) in orthodontics. Miniscrew has been a widely used Bone Anchor. Compared with mini-implant that necessitates osseointegration; mechanical retention is a determining factor for primary stability of miniscrew. Studies investigated various ways to increase primary stability. The aim of this study is to introduce a new configuration of miniscrew system which is believed to obtain more primary stability. Material and Methods Freshly ovine mandibles were cut in blocks. Twenty-seven miniscrews (diameter 1.6 × 8 mm; G2, Dual Top Anchor System, Jeil Medical, Seoul, Korea) were inserted in the blocks and divided in 2 experimental groups: single miniscrew and the innovated design “Seifi Twin Screw (STS)”. Primary stability was evaluated by Periotest “M”® device. Results Independent t-test showed a significant difference between 2 experimental groups in periotest evaluation (p< 0.05). STS demonstrated higher primary stability due to its mechanical configuration and design. Conclusions The STS provides higher primary stability and was found to be effective in increased success rate of miniscrew systems from the standpoint of primary stability. Key words:Anchorage procedures, anchorage techniques, orthodontic anchorage procedures, miniscrews, temporary anchorage device. PMID:27398174

  15. Developing Innovative Wall Systems that Improve Hygrothermal Performance of Residential Buildings

    SciTech Connect

    Robert Tichy; Chuck Murray

    2006-05-31

    This document serves as the Topical Report documenting work completed by Washington State University (WSU) under U.S. Department of Energy Grant, Developing Innovative Wall Systems that Improve Hygrothermal Performance of Residential Buildings. This project was conducted in collaboration with Oak Ridge National Laboratory (ORNL), and includes the participation of several industry partners including Weyerhaeuser, APA - The Engineered Wood Association, CertainTeed Corporation and Fortifiber. This document summarizes work completed by Washington State University August 2002 through June 2006. WSU's primary experimental role is the design and implementation of a field testing protocol that monitored long term changes in the hygrothermal response of wall systems. During the project period WSU constructed a test facility, developed a matrix of test wall designs, constructed and installed test walls in the test facility, installed instrumentation in the test walls and recorded data from the test wall specimens. Each year reports were published documenting the hygrothermal response of the test wall systems. Public presentation of the results was, and will continue to be, made available to the building industry at large by industry partners and the University.

  16. [Targeting mitochondria: innovation from mitochondrial drug delivery system (DDS) to mitochondrial medicine].

    PubMed

    Yamada, Yuma; Harashima, Hideyoshi

    2012-01-01

    Mitochondrial dysfunction has been implicated in a variety of human diseases, including cancer and neurodegenerative disorders. Effective medical therapies for such diseases will ultimately require the targeted delivery of therapeutic agents to mitochondria. This will likely be achieved through innovations in the areas of the nanotechnology of intracellular trafficking. Mitochondrial delivery systems for a variety of cargoes have been repored to date. However, only a limited number of approaches are available for delivering macromolecules directly to mitochondria. We previously reported on the construction of a MITO-Porter, a liposome-based carrier that introduces macromolecular cargos into mitochondria via membrane fusion. Using the green fluorescence protein as a model macromolecule in conjunction with analysis by confocal laser scanning microscopy, we were able to confirm the mitochondrial delivery of a macromolecule by the MITO-Porter. Moreover, we reported that the Dual Function MITO-Porter (DF-MITO-Porter) could efficiently deliver cargo to mitochondria, through endosomal and mitochondrial membranes via step-wise membrane fusion. Here, We will present our findings on the development of our mitochondrial drug delivery system, and discuss our attempts regarding mitochondrial gene delivery and therapy. Finally, We will discuss the potential use of mitochondrial drug delivery systems in mitochondrial medicine.

  17. Urban Water Innovation Network (UWIN): Transitioning Toward Sustainbale Urban Water Systems

    NASA Astrophysics Data System (ADS)

    Arabi, M.

    2015-12-01

    City water systems are at risk of disruption from global social and environmental hazards, which could have deleterious effects on human health, property, and loss of critical infrastructure. The Urban Water Innovation Network (UWIN), a consortium of 14 academic institutions and other key partners across the U.S., is working to address challenges that threaten urban water systems across the nation. UWIN's mission is to create technological, institutional and management solutions to help communities increase the resilience of their water systems and enhance their preparedness for responding to water crisis. The network seeks solutions that achieve widespread adoption consistent with inclusive, equitable and sustainable urban development. The integrative and adaptive analysis framework of UWIN is presented. The framework identifies a toolbox of sustainable solutions by simultaneously minimizing pressures, enhancing resilience to extreme events, and maximizing cobenefits. The benefits of sustainable urban water solutions for linked urban ecosystems, economies, and arrangements for environmental justice and social equity, will be discussed. The network encompasses six U.S. regions with varying ecohydrologic and climatic regimes ranging from the coastal moist mid-latitude climates of the Mid-Atlantic to the subtropical semi-arid deserts of the Southwest. These regions also represent a wide spectrum of demographic, cultural, and policy settings. The opportunities for cross-site assessments that facilitate the exploration of locally appropriate solutions across regions undergoing various development trajectories will be discussed.

  18. Developing Innovative Wall Systems that Improve Hygrothermal Performance of Residential Buildings

    SciTech Connect

    Robert Tichy; Chuck Murray

    2003-10-01

    This document serves as the Topical Report documenting the first year of work completed by Washington State University (WSU) under US Department of Energy Grant, Developing Innovative Wall Systems that Improve Hygrothermal Performance of Residential Buildings. This project is being conducted in collaboration with Oak Ridge National Laboratory (ORNL), and includes the participation of several industry partners including Weyerhaeuser Company, APA - The Engineered Wood Association, CertainTeed Corporation and Fortifiber. This document summarizes work completed by Washington State University August, 2002 through October, 2003. WSU's primary experimental role is the design and implementation of a field testing protocol that will monitor long term changes in the hygrothermal response of wall systems. In the first year WSU constructed a test facility, developed a matrix of test wall designs, constructed and installed test walls in the test facility, and installed instrumentation in the test walls. By the end of the contract period described in this document, WSU was recording data from the test wall specimens. The experiment described in this report will continue through December, 2005. Each year a number of reports will be published documenting the hygrothermal response of the test wall systems. Public presentation of the results will be made available to the building industry by industry partners and the University cooperators.

  19. Food systems transition and disruptive low carbon innovation: implications for a food security research agenda.

    PubMed

    Tyfield, David

    2011-07-01

    There is a growing consensus that we are facing epochal challenges in global food security. Moreover, these challenges are multiple and complex. Meeting these challenges will involve nothing less than a wholesale socio-technical transition of the agri-food system. Optimizing the efficacy of the contribution of research to such a food security agenda will probably also need new institutional mechanisms and career structures to facilitate new kinds of collaborations and ongoing, longer-term projects. In short, the multiple challenges of food security demand a different political economy of research for effective intervention by science. In making this argument, the paper summarizes the major findings of a recent report regarding the potential impact of so-called 'disruptive' low-carbon innovations in China.

  20. The Facial Contouring and Support System: An Innovative Method for Midfacial Fat Repositioning

    PubMed Central

    2014-01-01

    Summary: Minimally invasive rejuvenation procedures are increasingly popular with patients. In the midface, these might involve the introduction of sutures to lift and secure the malar tissue, fat grafts, and fillers to increase volume. This article describes a new facial contouring and support system, which uses an innovative hollow, double-beveled needle to which a 2/0 polypropylene suture may be anchored. Among 102 patients there were no complications, and follow-up at 3–5 years indicates little or no loss of satisfaction with the outcome. The procedure can be combined with other modalities—including fillers and skin peels—to achieve an overall, balanced, natural look for the patient. Potential adjustability and reversibility of the procedure are reassuring for both patient and surgeon and add to the technique’s versatility. PMID:25426398

  1. Problem Management Module: An Innovative System to Improve Problem List Workflow

    PubMed Central

    Hodge, Chad M.; Kuttler, Kathryn G.; Bowes, Watson A.; Narus, Scott P.

    2014-01-01

    Electronic problem lists are essential to modern health record systems, with a primary goal to serve as the repository of a patient’s current health issues. Additionally, coded problems can be used to drive downstream activities such as decision support, evidence-based medicine, billing, and cohort generation for research. Meaningful Use also requires use of a coded problem list. Over the course of three years, Intermountain Healthcare developed a problem management module (PMM) that provided innovative functionality to improve clinical workflow and boost problem list adoption, e.g. smart search, user customizable views, problem evolution, and problem timelines. In 23 months of clinical use, clinicians entered over 70,000 health issues, the percentage of free-text items dropped to 1.2%, completeness of problem list items increased by 14%, and more collaborative habits were initiated. PMID:25954372

  2. Problem management module: an innovative system to improve problem list workflow.

    PubMed

    Hodge, Chad M; Kuttler, Kathryn G; Bowes, Watson A; Narus, Scott P

    2014-01-01

    Electronic problem lists are essential to modern health record systems, with a primary goal to serve as the repository of a patient's current health issues. Additionally, coded problems can be used to drive downstream activities such as decision support, evidence-based medicine, billing, and cohort generation for research. Meaningful Use also requires use of a coded problem list. Over the course of three years, Intermountain Healthcare developed a problem management module (PMM) that provided innovative functionality to improve clinical workflow and boost problem list adoption, e.g. smart search, user customizable views, problem evolution, and problem timelines. In 23 months of clinical use, clinicians entered over 70,000 health issues, the percentage of free-text items dropped to 1.2%, completeness of problem list items increased by 14%, and more collaborative habits were initiated.

  3. Shock to the system: How catastrophic events and institutional relationships impact Japanese energy policymaking, resilience, and innovation

    NASA Astrophysics Data System (ADS)

    Sklarew, Jennifer F.

    External shocks do not always generate energy system transformation. This dissertation examines how government relationships with electric utilities and the public impact whether shocks catalyze energy system change. The study analyzes Japanese energy policymaking from the oil crises through the Fukushima nuclear disaster. Findings reveal that policymakers' cooperation with and clout over electric utilities and the public can enable shocks to transform energy systems. When electric utilities wield clout, public trust in and influence on the government determine the existing system's resilience and the potential for a new system to emerge. Understanding this effect informs energy policy design and innovation.

  4. An innovative web based system for reporting rare diseases in paediatrics

    PubMed Central

    Mukhi, Shamir N; Thibodeau, Melanie Laffin; Szijarto, Barbara

    2015-01-01

    Background Surveillance of rare diseases in children is an important aspect of public health. Rare diseases affect thousands of children worldwide. The Canadian Paediatric Surveillance Program (CPSP) has been in existence since 1996, and provides an innovative means to undertake paediatric surveillance and increase awareness of childhood disorders that are high in disability, morbidity, mortality, and economic costs to society, despite their low frequency. Traditionally, CPSP used manual paper-based reporting on a monthly basis, which although had an impressive response rate, it had inherent longer processing times and costs associated with it. Objectives To provide an overview and evaluate an innovative web-based system that enables seamless reporting from participants across the country providing a quick, reliable and simple mechanism for the participants to submit data while yielding better data quality, timeliness and increased efficiencies. Methods In 2011, a proprietary electronic CPSP (eCPSP) system was developed to provide a simple, quick and reliable reporting environment for participants. It supports both the electronic and hardcopy reporting. The analysis presented in this paper was conducted based on usage data of this system. Results The response rates of the new eCPSP were found to be very favorable with adjusted rate of 80%, which equals the baseline. Approximately 50% of online participants report the first day they receive the notification e-mail. The response time was also reduced considerably. Furthermore, there has been significant reduction in data handling related activities (by almost 70%) from estimated 690 hours per year. Finally, the number of cases reported that do not fit the study case criteria has fallen, likely because participants can now immediately access the case definition and protocol via the online system. This has reduced both staff and investigator time for case processing. Conclusion The eCPSP has modernized the CPSP program

  5. Analysis of substrate leachate from an innovative vertical flow AMD passive treatment system

    SciTech Connect

    Mercer, M.N.; Nairn, R.W.

    1999-07-01

    Although many organic substrate-based acid mine drainage (AMD) passive treatment systems have been constructed, analyses of initial leachate components has been limited. Labile organic materials, although providing an effective substrate for important bacterial processes in AMD treatment, may leach organic compounds, nutrients and other substances into receiving waters. Decreased dissolved oxygen levels, discoloration, nutrient enrichment and subsequent eutrophication may result. In this study, organic and inorganic components of substrate leachate from an innovative vertical flow acid mine drainage (AMD) passive treatment systems were determined during initial operation. A portion (approximately 17 L/minute) of an AMD discharge from an abandoned underground mine in southeastern Oklahoma was directed to a pilot-scale treatment system. The treatment system consists of four 185 m{sup 2} in-series cells and is comprised of alternating vertical flow anaerobic compost wetlands (VFs) and surface flow aerobic settling ponds (APs). the substrate in the VFs consists of spent mushroom substrate (SMS), high CaCO{sub 3} limestone gravel, and hydrated fly ash (HFA) in a 2:1:0.1 ratio by volume. HFA is a coal combustion product and has been identified as an effective alkalinity generating material in laboratory studies. Field data (pH, temperature, dissolved oxygen, conductivity and alkalinity) and water samples for subsequent analyses were collected at the discharge, at the inflow to each cell, and at several locations in the receiving waters. Initial data indicate pH increase to 7.3, and generation of approximately 150 mg/L alkalinity as CaCO{sub 3} eq. by the second aerobic settling pond. Total organic carbon, chemical oxygen demand, color, metals, and concentrations of other significant components were measured at all sampling locations.

  6. Quality testing of an innovative cascade separation system for multiple cell separation

    NASA Astrophysics Data System (ADS)

    Pierzchalski, Arkadiusz; Moszczynska, Aleksandra; Albrecht, Bernd; Heinrich, Jan-Michael; Tarnok, Attila

    2012-03-01

    Isolation of different cell types from mixed samples in one separation step by FACS is feasible but expensive and slow. It is cheaper and faster but still challenging by magnetic separation. An innovative bead-based cascade-system (pluriSelect GmbH, Leipzig, Germany) relies on simultaneous physical separation of different cell types. It is based on antibody-mediated binding of cells to beads of different size and isolation with sieves of different mesh-size. We validated pluriSelect system for single parameter (CD3) and simultaneous separation of CD3 and CD15 cells from EDTA blood-samples. Results were compared with those obtained by MACS (Miltenyi-Biotech) magnetic separation (CD3 separation). pluriSelect separation was done in whole blood, MACS on Ficoll gradient isolated leukocytes, according to the manufacturer's protocols. Isolated and residual cells were immunophenotyped (7-color 8-antibody panel (CD3; CD16/56; CD4; CD8; CD14; CD19; CD45; HLADR) on a CyFlowML flow cytometer (Partec GmbH). Cell count (Coulter), purity, yield and viability (7-AAD exclusion) were determined. There were no significant differences between both systems regarding purity (92-98%), yield (50-60%) and viability (92-98%) of isolated cells. PluriSelect separation was slightly faster than MACS (1.15 h versus 1.5h). Moreover, no preenrichment steps were necessary. In conclusion, pluriSelect is a fast, simple and gentle system for efficient simultaneous separation of two cell subpopulation directly from whole blood and can provide a simple alternative to FACS. The isolated cells can be used for further research applications.

  7. Innovative permeable cover system to reduce risks at a chemical munitions burial site

    SciTech Connect

    Powels, C.C.; Bon, I.; Okusu, N.M.

    1997-12-31

    An innovative permeable sand cover with various integrated systems has been designed to contain and treat the Old O-Field chemical munitions landfill at Aberdeen Proving Ground, Maryland. The 18,200 m{sup 2} (4.5 acre) landfill was used from the mid 1930s to the mid 1950s for the disposal of chemical, incendiary, and explosive munitions from domestic and foreign origins, together with contaminated wastes associated with the development and production of chemical warfare agents (CWA). The site is suspected to be contaminated with white phosphorous (WP) (which when dry, spontaneously burns when exposed to air), shock sensitive picric acid fuses and has the potential to contain large quantities of CWA-filled munitions. Historically, one to three explosions or fires occurred per ten-year period at the landfill. Such events have the potential to cause a CWA release to the environment, which could potentially affect densely populated areas. Recovery and decontamination projects conducted at the site in the late 1940s and early 1950s used large amounts of decontamination chemicals (containing solvents) and fuels which further contaminated the area. The groundwater downgradient of the landfill is contaminated with volatile organic compounds, metals, explosives and CWA degradation compounds and is currently being contained by a groundwater extraction and treatment system. This report describes a remedial action program for the site.

  8. Hygehos Home: an innovative remote follow-up system for chronic patients.

    PubMed

    Carrasco, Eduardo; Sánchez, Eider; Artetxe, Arkaitz; Toro, Carlos; Graña, Manuel; Guijarro, Frank; Susperregui, José María; Aguirre, Agustín

    2014-01-01

    This paper describes an innovative architecture for the remote follow-up of the health of chronic patients, and its implementation which is called Hygehos Home. The main purpose of the system is to enhance the quality of the daily healthcare practice, by means of bringing both patient and medical professionals closer to each other and by empowering the patient in the healing process. On the one side, Hygehos Home is a platform which gives the patient access to a set of personalized e-Health services using different channels such as web or smartphone. The e-Health services currently provided are: a) health related questionnaires, b) vital sign delivery (weight, blood pressure, oxygen level in blood, temperature, etc.), c) pharmacologic treatment adherence follow-up, d) access to information about the disease, and e) direct communication with the care providers (physicians, nurses, etc.). On the other side, Hygehos Home is fully integrated in the Hospital Information System (HIS), so that the healthcare professionals can easily access all data registered by the patients, such as subjective feedback, vital signs, medication uptake, etc. In this way, the health professionals are able to conduct an efficient and continuous remote supervision of the evolution of the patient. Finally, the validation protocol being conducted is described.

  9. Beyond feedback control: the interactive use of performance management systems. Implications for process innovation in Italian healthcare organizations.

    PubMed

    Demartini, Chiara; Mella, Piero

    2014-01-01

    This paper shows how the use of performance management systems affects managers' perception of satisfaction, the effectiveness of the control system and the performance related to process innovation. An exploratory empirical research has been conducted on 85 managers operating in Italian healthcare organizations. Empirical findings put forward that the interactive--as opposed to diagnostic--use of performance management systems enhances managerial satisfaction with the control system and managerial perception of effectiveness. The present study then showed that it is not the control itself that is an obstacle to innovation in organizations in general (and in health organizations in particular) but the diagnostic use of the control mechanisms, which impedes the interaction between the control personnel and those subject to the control. Finally, this paper addresses managerial implications and further research avenues.

  10. Active control of an innovative seat suspension system with acceleration measurement based friction estimation

    NASA Astrophysics Data System (ADS)

    Ning, Donghong; Sun, Shuaishuai; Li, Hongyi; Du, Haiping; Li, Weihua

    2016-12-01

    In this paper, an innovative active seat suspension system for vehicles is presented. This seat suspension prototype is built with two low cost actuators each of which has one rotary motor and one gear reducer. A H∞ controller with friction compensation is designed for the seat suspension control system where the friction is estimated and compensated based on the measurement of seat acceleration. This principal aim of this research was to control the low frequency vibration transferred or amplified by the vehicle (chassis) suspension, and to maintain the passivity of the seat suspension at high frequency (isolation vibration) while taking into consideration the trade-off between the active seat suspension cost and its high frequency performance. Sinusoidal excitations of 1-4.5 Hz were applied to test the active seat suspension both when controlled and when uncontrolled and this is compared with a well-tuned passive heavy duty vehicle seat suspension. The results indicate the effectiveness of the proposed control algorithm within the tested frequencies. Further tests were conducted using the excitations generated from a quarter-car model under bump and random road profiles. The bump road tests indicate the controlled active seat suspension has good transient response performance. The Power Spectral Density (PSD) method and ISO 2631-1 standards were applied to analyse the seat suspension's acceleration under random road conditions. Although some low magnitude and high frequency noise will inevitably be introduced by the active system, the weighted-frequency Root Mean Square (RMS) acceleration shows that this may not have a large effect on ride comfort. In fact, the ride comfort is improved from being an 'a little uncomfortable' to a 'not uncomfortable' level when compared with the well-tuned passive seat suspension. This low cost active seat suspension design and the proposed controller with the easily measured feedback signals are very practical for real

  11. A decision support system for technology R&D planning: connecting the dots from information to innovation

    NASA Technical Reports Server (NTRS)

    Smith, Jeffrey H.; Wertz, Julie; Weisbin, Charles

    2004-01-01

    This paper describes an information technology innovation developed to assist decision makers faced with complex R&D tasks. The decision support system (DSS) was developed and applied to the analysis of a 10-year, 700 million dollar technology program for the exploration of Mars. The technologies were to enable a 4.8 billion dollar portfolio of exploration flight missions to Mars.

  12. Development of the System of Investment Support of Projects in the Industrial-Innovative Development of Kazakhstan

    ERIC Educational Resources Information Center

    Doskaliyeva, Bayan B.; Orynbassarova, Yerkenazym D.; Omarkhanov?, Zhibek M.; Karibaev, Yerkebulan S.; Baimukhametova, Ayagul S.

    2016-01-01

    The purpose of this study is to determine specific features of investment regulation mechanism aimed at providing effective implementation of projects in the context of industrial-innovative development of Kazakhstan. There the used the system of general scientific and special research methods providing the possibility to disclose processes and…

  13. Pedagogical Reforms within a Centralised-Decentralised System: A Singapore's Perspective to Diffuse 21st Century Learning Innovations

    ERIC Educational Resources Information Center

    Toh, Yancy; Hung, Wei Loong David; Chua, Paul Meng-Huat; He, Sujin; Jamaludin, Azilawati

    2016-01-01

    Purpose: The purpose of this paper is to illustrate the dialectical interplay between centralisation and decentralisation forces so as to understand how schools leverage on its autonomous pedagogical space, influence the diffusion of innovations in the educational landscape of Singapore and how a centralised-decentralised system supports (or…

  14. Strengthening Agricultural Education and Training in Sub-Saharan Africa from an Innovation Systems Perspective: A Case Study of Mozambique

    ERIC Educational Resources Information Center

    Davis, Kristin E.; Ekboir, Javier; Spielman, David J.

    2008-01-01

    This paper examines how post-secondary agricultural education and training (AET) in sub-Saharan Africa can contribute to agricultural development by strengthening the capacity to innovate--to introduce new products and processes that are socially or economically relevant to smallholder farmers and other agents. Using the AET system in Mozambique…

  15. With or without a Script? Comparing Two Styles of Participatory Video on Enhancing Local Seed Innovation System in Bangladesh

    ERIC Educational Resources Information Center

    Chowdhury, Ataharul Huq; Odame, Helen Hambly; Hauser, Michael

    2010-01-01

    Recent experiences in participatory video-making raise the question of how best to use this medium for enhancing local seed innovation systems. Embedded in a mini-process of participatory action research, two styles of participatory video--scripted and scriptless--were tested and assessed together with farmers and facilitators in Bogra District,…

  16. Adding Innovation Diffusion Theory to the Technology Acceptance Model: Supporting Employees' Intentions to Use E-Learning Systems

    ERIC Educational Resources Information Center

    Lee, Yi-Hsuan; Hsieh, Yi-Chuan; Hsu, Chia-Ning

    2011-01-01

    This study intends to investigate factors affecting business employees' behavioral intentions to use the e-learning system. Combining the innovation diffusion theory (IDT) with the technology acceptance model (TAM), the present study proposes an extended technology acceptance model. The proposed model was tested with data collected from 552…

  17. An Efficacious Measurement of Learning Initiatives: E-Learning Systems, Learning-Organization Culture, Knowledge Creation, and Innovativeness

    ERIC Educational Resources Information Center

    Grundhoefer, Raymie

    2013-01-01

    The purpose of this research is twofold: (a) develop a validated measure for learning initiatives based on knowledge-creation theory and (b) conduct a quantitative study to investigate the relationships between electronic learning systems, learning-organization culture, efficacious knowledge creation (EKC), and innovativeness. Although Cheng-Chang…

  18. Partnerships for Productivity and Advanced Skills: The Role of Colleges in Canada's Innovation System. A Background Paper

    ERIC Educational Resources Information Center

    Association of Canadian Community Colleges, 2010

    2010-01-01

    The paper provides an assessment of what we currently know about college, institute and polytechnic (collectively described here as colleges) applied research and positions them as key players in Canada's innovation system and in the federal science and technology strategy. The paper builds upon findings of previous research and reports on the…

  19. A Survey of University Faculty Innovation Concerns and Perceptions that Influence the Adoption and Diffusion of a Course Management System

    ERIC Educational Resources Information Center

    McQuiggan, Carol A.

    2006-01-01

    Survey research was conducted to describe university faculty innovation concerns and perceptions that influence the adoption and diffusion of a course management system (CMS). Significant differences were found between adopters and nonadopters on their perceptions of the CMS attributes, on their Stages of Concern, and on their communication…

  20. INNOVATIVE TECHNOLOGY VERIFICATION REPORT "FIELD MEASUREMENT TECHNOLOGIES FOR TOTAL PETROLEUM HYDROCARBONS IN SOIL" DEXSIL CORPORATION PETROFLAG SYSTEM

    EPA Science Inventory



    The PetroFLAGTm System developed by Dexsilo Corporation (Dexsil) was demonstrated under the U.S. Environmental Protection Agency Superfund Innovative Technology Evaluation Program in June 2000 at the Navy Base Ventura County site in Port Hueneme, California. The purpose o...

  1. INNOVATIVE TECHNOLOGY VERIFICATION REPORT "FIELD MEASUREMENT TECHNOLOGIES FOR TOTAL PETROLEUM HYDROCARBONS IN SOIL" STRATEGIC DIAGNOSTICS INC. ENSYS PETRO TEST SYSTEM

    EPA Science Inventory



    The EnSys Petro Test System developed by Strategic Diagnostics Inc. (SDI), was demonstrated under the U.S. Environmental Protection Agency Superfund Innovative Technology Evaluation Program in June 2000 at the Navy Base Ventura County site in Port Hueneme, California. The...

  2. Quality Certification, Institutions and Innovation in Local Agro-Food Systems: Protected Designations of Origin of Olive Oil in Spain

    ERIC Educational Resources Information Center

    Canada, Javier Sanz; Vazquez, Alfredo Macias

    2005-01-01

    This article examines the interrelations between establishment of territorial quality certification systems (Protected Designations of Origin or PDOs), diffusion of innovations through local agro-food chains, and the role of the institutions overseeing geographical designations. Empirical analysis is applied to olive oil PDOs in Spain and entails…

  3. Non-Traditional/Innovative Instructional Delivery Systems: A Literature Search for Institutions Daring to Deviate from the Conventional.

    ERIC Educational Resources Information Center

    Roberts, Frank C.

    Literature-search techniques and personal contacts were used to develop a list of 52 colleges with innovative and non-traditional educational delivery systems. These schools were contacted to obtain catalogs and other descriptive, program information. By October 1978, 38 colleges had responded. Of these, 16 had particularly creative and innovative…

  4. A Return to Innovative Engineering Design, Critical Thinking and Systems Engineering

    NASA Technical Reports Server (NTRS)

    Camarda, Charles J.

    2007-01-01

    I believe we are facing a critical time where innovative engineering design is of paramount importance to the success of our aerospace industry. However, the very qualities and attributes necessary for enhancing, educating, and mentoring a creative spirit are in decline in important areas. The importance of creativity and innovation in this country was emphasized by a special edition of the Harvard Business Review OnPoint entitled: "The Creative Company" which compiled a series of past and present articles on the subject of creativity and innovation and stressed its importance to our national economy. There is also a recognition of a lack of engineering, critical thinking and problem-solving skills in our education systems and a trend toward trying to enhance those skills by developing K-12 educational programs such as Project Lead the Way, "Science for All Americans", Benchmarks 2061 , etc. In addition, with respect to spacecraft development, we have a growing need for young to mid-level engineers with appropriate experience and skills in spacecraft design, development, analysis, testing, and systems engineering. As the Director of Engineering at NASA's Johnson Space Center, I realized that sustaining engineering support of an operational human spacecraft such as the Space Shuttle is decidedly different than engineering design and development skills necessary for designing a new spacecraft such as the Crew Exploration Vehicle of the Constellation Program. We learned a very important lesson post Columbia in that the Space Shuttle is truly an experimental and not an operational vehicle and the strict adherence to developed rules and processes and chains of command of an inherently bureaucratic organizational structure will not protect us from a host of known unknowns let alone unknown unknowns. There are no strict rules, processes, or procedures for understanding anomalous results of an experiment, anomalies with an experimental spacecraft like Shuttle, or in the

  5. Evaluation of the Relative Contribution of Observing Systems in Reanalyses: Aircraft Temperature Bias and Analysis Innovations

    NASA Technical Reports Server (NTRS)

    Bosilovich, Michael G.; Dasilva, Arindo M.

    2012-01-01

    Reanalyses have become important sources of data in weather and climate research. While observations are the most crucial component of the systems, few research projects consider carefully the multitudes of assimilated observations and their impact on the results. This is partly due to the diversity of observations and their individual complexity, but also due to the unfriendly nature of the data formats. Here, we discuss the NASA Modern-Era Retrospective analysis for Research and Applications (MERRA) and a companion dataset, the Gridded Innovations and Observations (GIO). GIO is simply a post-processing of the assimilated observations and their innovations (forecast error and analysis error) to a common spatio-temporal grid, following that of the MERRA analysis fields. This data includes in situ, retrieved and radiance observations that are assimilated and used in the reanalysis. While all these disparate observations and statistics are in a uniform easily accessible format, there are some limitations. Similar observations are binned to the grid, so that multiple observations are combined in the gridding process. The data is then implicitly thinned. Some details in the meta data may also be lost (e.g. aircraft or station ID). Nonetheless, the gridded observations should provide easy access to all the observations input to the reanalysis. To provide an example of the GIO data, a case study evaluating observing systems over the United States and statistics is presented, and demonstrates the evaluation of the observations and the data assimilation. The GIO data is used to collocate 200mb Radiosonde and Aircraft temperature measurements from 1979-2009. A known warm bias of the aircraft measurements is apparent compared to the radiosonde data. However, when larger quantities of aircraft data are available, they dominate the analysis and the radiosonde data become biased against the forecast. When AMSU radiances become available the radiosonde and aircraft analysis and

  6. FEED SYSTEM INNOVATION FOR GASIFICATION OF LOCALLY ECONOMICAL ALTERNATIVE FUELS (FIGLEAF)

    SciTech Connect

    Michael L. Swanson; Mark A. Musich; Darren D. Schmidt; Joseph K. Schultz

    2003-02-01

    The Feed System Innovation for Gasification of Locally Economical Alternative Fuels (FIGLEAF) project was conducted by the Energy & Environmental Research Center and Gasification Engineering Corporation of Houston, Texas (a subsidiary of Global Energy Inc., Cincinnati, Ohio), with 80% cofunding from the U.S. Department of Energy (DOE). The goal of the project was to identify and evaluate low-value fuels that could serve as alternative feedstocks and to develop a feed system to facilitate their use in integrated gasification combined-cycle and gasification coproduction facilities. The long-term goal, to be accomplished in a subsequent project, is to install a feed system for the selected fuel(s) at Global Energy's commercial-scale 262-MW Wabash River Coal Gasification Facility in West Terre Haute, Indiana. The feasibility study undertaken for the project consisted of identifying and evaluating the economic feasibility of potential fuel sources, developing a feed system design capable of providing a fuel at 400 psig to the second stage of the E-Gas (Destec) gasifier to be cogasified with coal, performing bench- and pilot-scale testing to verify concepts and clarify decision-based options, reviewing information on high-pressure feed system designs, and determining the economics of cofeeding alternative feedstocks with the conceptual feed system design. A preliminary assessment of feedstock availability within Indiana and Illinois was conducted. Feedstocks evaluated included those with potential tipping fees to offset processing cost: sewage sludge, municipal solid waste, used railroad ties, urban wood waste (UWW), and used tires/tire-derived fuel. Agricultural residues and dedicated energy crop fuels were not considered since they would have a net positive cost to the plant. Based on the feedstock assessment, sewage sludge was selected as the primary feedstock for consideration at the Wabash River Plant. Because of the limited waste heat available for drying and the

  7. An Innovative Approach to Resident Scheduling: Use of a Point-Based System to Account for Resident Preferences

    PubMed Central

    Chow, Robert Tao-Ping; Tamhane, Shrikant; Zhang, Manling; Fisher, Lori-Ann; Yoon, Jenni; Sehgal, Sameep; Lumbres, Madel; Han, Ma Ai Thanda; Win, Tiffany

    2015-01-01

    Background The scheduling of residents for rotation assignments and on-call responsibilities is a time-consuming process that challenges the resources of residency programs. Assignment of schedules is traditionally done by chief residents or program administration with variable input from the residents involved. Intervention We introduced an innovative point-based scheduling system to increase transparency in the scheduling process, foster a sense of fairness and equality in scheduling, and increase resident ownership for making judicious scheduling choices. Methods We devised a point-based system in which each resident in our 40-member program was allocated an equal number of points. The residents assigned these points to their preferred choices of rotations. Residents were then surveyed anonymously on their perceptions of this new scheduling system and were asked to compare it with their traditional scheduling system. Results The schedule was successfully implemented, and it allowed residents to express their scheduling preferences using an innovative point-based approach. Residents were generally satisfied with the new system, would recommend it to other programs, and perceived a greater sense of involvement. However, resident satisfaction with the new system was not significantly greater compared with the previous approach to scheduling (P = .20). Chief residents expressed satisfaction with the new scheduling model. Conclusions Residents were equally satisfied with the traditional preference-based scheduling approach and the new point-based system. Chief residents' feedback on the new system reflected reduced stress and time commitment in the new point-based system. PMID:26457154

  8. Innovations in health and demographic surveillance systems to establish the causal impacts of HIV policies

    PubMed Central

    Herbst, Kobus; Law, Matthew; Geldsetzer, Pascal; Tanser, Frank; Harling, Guy; Bärnighausen, Till

    2016-01-01

    Purpose of Review Health and Demographic Surveillance Systems (HDSS), in conjunction with HIV treatment cohorts, have made important contributions to our understanding of the impact of HIV treatment and treatment-related interventions in sub-Saharan Africa. The purpose of this review is to describe and discuss innovations in data collection and data linkage that will create new opportunities to establish the impacts of HIV treatment, as well as policies affecting the treatment cascade, on population health, economic and social outcomes. Recent Findings Novel approaches to routine collection of (i) biomarkers, (ii) behavioural data, (iii) spatial data, (iv) social network information, (v) migration events and (vi) mobile phone records can significantly strengthen the potential of HDSS to generate exposure and outcome data for causal analysis of HIV treatment impact and policies affecting the HIV treatment cascade. Additionally, by linking HDSS data to health service administration, education, and welfare service records, researchers can substantial broaden opportunities to establish how HIV treatment affects health and economic outcomes, when delivered through public-sector health systems and at scale. Summary As the HIV treatment scale-up in sub-Saharan Africa enters its second decade, it is becoming increasingly important to understand the long-term causal impacts of large-scale HIV treatment and related policies on broader population health outcomes, such as non-communicable diseases, as well as on economic and social outcomes, such as family welfare and children’s educational attainment. By collecting novel data and linking existing data to public-sector records, HDSS can create near-unique opportunities to contribute to this research agenda. PMID:26371462

  9. Innovative coke oven gas cleaning system for retrofit applications. Volume 1, Public design report

    SciTech Connect

    Not Available

    1994-05-24

    This Public Design Report provides, in a single document, available nonproprietary design -information for the ``Innovative Coke Oven Gas Cleaning System for Retrofit Applications`` Demonstration Project at Bethlehem Steel Corporation`s Sparrows Point, Maryland coke oven by-product facilities. This project demonstrates, for the first time in the United States, the feasibility of integrating four commercially available technologies (processes) for cleaning coke oven gas. The four technologies are: Secondary Gas Cooling, Hydrogen Sulfide and Ammonia Removal, Hydrogen Sulfide and Ammonia Recovery, and Ammonia Destruction and Sulfur Recovery. In addition to the design aspects, the history of the project and the role of the US Department of,Energy are briefly discussed. Actual plant capital and projected operating costs are also presented. An overview of the integration (retrofit) of the processes into the existing plant is presented and is followed by detailed non-proprietary descriptions of the four technologies and their overall effect on reducing the emissions of ammonia, sulfur, and other pollutants from coke oven gas. Narrative process descriptions, simplified process flow diagrams, input/output stream data, operating conditions, catalyst and chemical requirements, and utility requirements are given for each unit. Plant startup provisions, environmental considerations and control monitoring, and safety considerations are also addressed for each process.

  10. Visual Comfort Analysis of Innovative Interior and Exterior Shading Systems for Commercial Buildings using High Resolution Luminance Images

    SciTech Connect

    Konis, Kyle; Lee, Eleanor; Clear, Robert

    2011-01-11

    The objective of this study was to explore how calibrated high dynamic range (HDR) images (luminance maps) acquired in real world daylit environments can be used to characterize, evaluate, and compare visual comfort conditions of innovative facade shading and light-redirecting systems. Detailed (1536 x 1536 pixel) luminance maps were time-lapse acquired from two view positions in an unoccupied full scale testbed facility. These maps were analyzed using existing visual comfort metrics to quantify how innovative interior and exterior shading systems compare to conventional systems under real sun and sky conditions over a solstice-to-solstice test interval. The results provide a case study in the challenges and potential of methods of visualizing, evaluating and summarizing daily and seasonal variation of visual comfort conditions computed from large sets of image data.

  11. FEED SYSTEM INNOVATION FOR GASIFICATION OF LOCALLY ECONOMICAL ALTERNATIVE FUELS (FIGLEAF)

    SciTech Connect

    Michael L. Swanson; Mark A. Musich; Darren D. Schmidt

    2001-11-01

    The Feed System Innovation for Gasification of Locally Economical Alternative Fuels (FIGLEAF) project is being conducted by the Energy and Environmental Research Center and Gasification Engineering Corporation of Houston, Texas (a subsidiary of Global Energy Inc., Cincinnati, Ohio), with 80% cofunding from the U.S. Department of Energy. The goal of the project is to identify and evaluate low-value fuels that could serve as alternative feedstocks and to develop a feed system to facilitate their use in integrated gasification combined cycle and gasification coproduction facilities. The long-term goal, to be accomplished in a subsequent project, is to install a feed system for the selected fuels at Global Energy's commercial-scale 262-MW Wabash River Coal Gasification Facility in West Terre Haute, Indiana. The feasibility study undertaken for the project consists of identifying and evaluating the economic feasibility of potential fuel sources, developing a feed system design capable of providing a fuel at 400 psig to the second stage of the E-Gas (Destec) gasifier to be cogasified with coal at up to 30% on a Btu basis, performing bench- and pilot-scale testing to verify concepts and clarify decision-based options, reviewing prior art with respect to high-pressure feed system designs, and determining the economics of cofeeding alternative feedstocks with the conceptual feed system design. Activities and results thus far include the following. Several potential alternative fuels have been obtained for evaluation and testing as potential feedstocks, including sewage sludge, used railroad ties, urban wood waste, municipal solid waste, and used waste tires/tire-derived fuel. Only fuels with potential tipping fees were considered; potential energy crop fuels were not considered since they would have a net positive cost to the plant. Based on the feedstock assessment, sewage sludge has been selected as one of the primary feedstocks for consideration at the Wabash plant

  12. Design and modelling of an innovative three-stage thermal storage system for direct steam generation CSP plants

    NASA Astrophysics Data System (ADS)

    Garcia, Pierre; Vuillerme, Valéry; Olcese, Marco; El Mourchid, Nadim

    2016-05-01

    Thermal Energy Storage systems (TES) for a Direct Steam Generation (DSG) solar plant feature preferably three stages in series including a latent heat storage module so that steam can be recovered with a limited temperature loss. The storage system designed within the Alsolen Sup project is characterized by an innovative combination of sensible and latent modules. A dynamic model of this three-stage storage has been developed and applied to size the storage system of the Alsolen Sup® plant demonstrator at CEA Cadarache. Results of this simulation show that this promising concept is an efficient way to store heat in DSG solar plants.

  13. Innovative Embedded Fiber Sensor System for Spacecraft's Health in Situ Monitoring

    NASA Astrophysics Data System (ADS)

    Haddad, E.; Kruzelecky, R.; Zou, J.; Wong, B.; Mohammad, N.; Thatte, G.; Jamroz, W.; Riendeau, S.

    2009-01-01

    Monitoring of various parameters in satellites is desirable to provide the necessary information on the condition and status of the spacecraft and its various subsystems (AOCS, thermal, propulsion, power, mechanisms etc.) throughout its lifecycle. Fiber-Optic Bragg Grating (FBG) sensors represent an alternative to current technological approaches, enabling in situ distributed dynamic health monitoring, to provide a mapping of the spacecraft strain and temperature distributions, for varying operating and orbital conditions. In addition, these sensors may be implemented in the very early spacecraft fabrication stages, as built-in testing and diagnostic tools, and then used continuously through the mission phases until the end of the spacecraft mission. This can substantially reduce the cost of ground qualification and facilitate improved spacecraft design. MPBC has developed and ground qualified a demonstrator fiber sensor network, the Fiber Sensor Demonstrator (FSD) that has been successfully integrated with ESA's Proba-2. This is scheduled to launch in the fall of 2008, and will be the first complete fiber-optic sensing system in space. The advantages of the MPBC approach include a central interrogation system that can be used to control a multi-parameter sensing incorporating various types of sensors. Using a combination of both parallel signal distribution and serial wavelength division sensor multiplexing along single strands of optical fiber enables a high sensor capacity. In a continuous effort, MPB Communications (MPBC) is developing an innovative Embedded Distributed Fiber Sensor (EDFOS) within space composite structures. It addresses the challenges of embedding very thin fiber sensors within a selected material matrix, the decoupling of the strain and temperature effects on the fiber, and the sensor distribution. The embedded sensor approach allows the sensor system to follow the status of the space structure through its entire life cycle; from fabrication

  14. VIENTOS: a feasibility study of innovative pupil systems for the new generation of instruments in the large telescopes

    NASA Astrophysics Data System (ADS)

    García-Vargas, M. L.; Pérez-Calpena, A.; Gallego, J.; Gil de Paz, A.; Sánchez-Blanco, E.; Martínez-Delgado, I.; Maldonado Medina, M.; Zamorano Calvo, J.

    2012-09-01

    The goal of VIENTOS project is to analyze pupil innovative systems that could be used in the new generation of instruments for the large telescopes. This study tries to identify the current scientific needs, to understand why some of them have not been fulfilled yet (due to pre-conceived technical ideas or to managerial reasons) and to propose optomechanical solutions for these pupil elements that could produce a qualitative leap in the performance of the instruments to operate in the large telescopes. VIENTOS is currently on-going as a collaborative project between FRACTAL and the University Complutense of Madrid (UCM) and is being partially funded by a CDTI grant under the program Industry for Science. CDTI is the Development and Industrial Transfer Center from the Minister of Science and Innovation (Spain). Among the different innovative systems that we have carried out, our team has explored potential solutions for narrow band Imaging with tunable filters in the near-IR and a novel pupil system called sliced-pupil grating, a device designed for increasing the spectral resolution in astronomical spectrographs, without changing the geometry of the main optics. Nanotechnology customized filters to be applicable to astronomical systems are under study.

  15. Innovation in the role of the Office of the Ombudsman of the Unified Health System (SUS) - reflections and potential benefits.

    PubMed

    Fernandes, Fernando Manuel Bessa; Moreira, Marcelo Rasga; Ribeiro, José Mendes; Ouverney, Assis Mafort; Oliveira, Flávio José Fonseca de; Moro, Maria Francisca Abritta

    2016-08-01

    This article seeks to reflect on the potential of innovative practices in the design and work of the government bodies that comprise the National System of Offices of the Ombudsman of the Unified Health System. It is divided into two parts, seeking to answer the following question: How to think of and implement innovative practices - which include sustainability - when the people are voicing their urgent demands and these are being heard by the public authorities? These grievances are all the more urgent as they involve the area of Health and can they be promptly discussed, attended and resolved? In the first part, the article discusses the polysemic concept of innovation, focusing on its application in the three spheres of public administration, and highlights the importance of its close correlation with the different notions of information and knowledge in a society such as the one we live in. In the second, it develops a task-force of ideas for the office of the ombudsman and based on this, a draft operational concept of innovation in the role of the office of the ombudsman, considering the context of high speed change and transformations and the complexity inherent to contemporary life and the need for resource management and expertise development in information management. PMID:27557027

  16. Innovation in the role of the Office of the Ombudsman of the Unified Health System (SUS) - reflections and potential benefits.

    PubMed

    Fernandes, Fernando Manuel Bessa; Moreira, Marcelo Rasga; Ribeiro, José Mendes; Ouverney, Assis Mafort; Oliveira, Flávio José Fonseca de; Moro, Maria Francisca Abritta

    2016-08-01

    This article seeks to reflect on the potential of innovative practices in the design and work of the government bodies that comprise the National System of Offices of the Ombudsman of the Unified Health System. It is divided into two parts, seeking to answer the following question: How to think of and implement innovative practices - which include sustainability - when the people are voicing their urgent demands and these are being heard by the public authorities? These grievances are all the more urgent as they involve the area of Health and can they be promptly discussed, attended and resolved? In the first part, the article discusses the polysemic concept of innovation, focusing on its application in the three spheres of public administration, and highlights the importance of its close correlation with the different notions of information and knowledge in a society such as the one we live in. In the second, it develops a task-force of ideas for the office of the ombudsman and based on this, a draft operational concept of innovation in the role of the office of the ombudsman, considering the context of high speed change and transformations and the complexity inherent to contemporary life and the need for resource management and expertise development in information management.

  17. Playing a 3-Stringed Violin: Innovation via the Joint Evolution of People, Process, and Knowledge Management System

    NASA Technical Reports Server (NTRS)

    Cooper, Lynne P.

    2010-01-01

    Users continuously evaluate the value and performance of their Knowledge Management Systems (KMS). As suggested by a punctuated socio-technical system process model, today's success can quickly become tomorrow's failure should the KMS fail to meet evolving needs and expectations. The more deeply a tool is embedded in the actual work process, the more vulnerable it is to emergent changes and perturbations. This paper uses the metaphor of a "3-stringed violin" to explore how differing levels of user knowledge about tools and processes can lead to system perturbations and how the active involvement of other actors can dampen the impact of perturbations, i.e., help the system survive the operational equivalent of a broken string. Recommendations suggest ways to increase system resiliency and contribute to incremental innovation.

  18. An actor-network theory analysis of policy innovation for smoke-free places: understanding change in complex systems.

    PubMed

    Young, David; Borland, Ron; Coghill, Ken

    2010-07-01

    Complex, transnational issues like the tobacco epidemic are major challenges that defy analysis and management by conventional methods, as are other public health issues, such as those associated with global food distribution and climate change. We examined the evolution of indoor smoke-free regulations, a tobacco control policy innovation, and identified the key attributes of those jurisdictions that successfully pursued this innovation and those that to date have not. In doing so, we employed the actor-network theory, a comprehensive framework for the analysis of fundamental system change. Through our analysis, we identified approaches to help overcome some systemic barriers to the solution of the tobacco problem and comment on other complex transnational problems.

  19. An Actor-Network Theory Analysis of Policy Innovation for Smoke-Free Places: Understanding Change in Complex Systems

    PubMed Central

    Borland, Ron; Coghill, Ken

    2010-01-01

    Complex, transnational issues like the tobacco epidemic are major challenges that defy analysis and management by conventional methods, as are other public health issues, such as those associated with global food distribution and climate change. We examined the evolution of indoor smoke-free regulations, a tobacco control policy innovation, and identified the key attributes of those jurisdictions that successfully pursued this innovation and those that to date have not. In doing so, we employed the actor-network theory, a comprehensive framework for the analysis of fundamental system change. Through our analysis, we identified approaches to help overcome some systemic barriers to the solution of the tobacco problem and comment on other complex transnational problems. PMID:20466949

  20. An innovative pot system for monitoring the effects of water stress on grapevines and grape quality

    NASA Astrophysics Data System (ADS)

    Puccioni, Sergio; Leprini, Marco; Mocali, Stefano; Perria, Rita; Priori, Simone; Storchi, Paolo; Zombardo, Alessandra; Costantini, Edoardo

    2016-04-01

    The advantage of a pot system is the possibility to control many variables and factors with a large number of replicates, obtaining statistically significant results in only one year of experimentation. An innovative pot system for the monitoring of grapevine water stress was set up. The system consists of 99 pots of 70 liters, filled by 3 different soils collected from premium vineyards of the Chianti Classico district (Tuscany). The soils showed different texture (clay-loam, loam and sandy-loam), different gravel and carbonate content, and different available water capacity (AWC). The same soils had been field monitored for grapevine water stress; therefore it was possible to compare the grapevine behaviour both in pot and in field conditions. The grapevine cultivar was Pinot noir clone ENTAV 115, which can be used to investigate the genetic expression in response to environmental factors, since its genome has been sequenced. Different rootstocks theses were compared: not grafted, 1103 Paulsen and M101-14. Each combination rootstock-soil was repeated 9 times. Every pot was equipped for drip irrigation and with electrodes for soil moisture determination by TDR. A non-stop automated control unit recorded meteorological data (temperature and rainfalls), soil temperature and water potential on 9 selected pots. These 9 selected pots were also used to calibrate a model for soil water volume/tension curve. Soil, leaves and grapes samples from each pot were collected for microbial community determination, through NGS analysis. A preliminary study was based on testing the ability of the system to simulate the natural growing conditions of the grapevines. Therefore the grape performances of the potted plants were compared to those of plants cultivated in the vineyards where the soils were taken. In July 2015 three levels of water supply were tested during 5 weeks (up to veraison) in order to study the effects of water stress on the plants and the grape. Later, all the pots

  1. An Innovative Method of Teaching Electronic System Design with PSoC

    ERIC Educational Resources Information Center

    Ye, Zhaohui; Hua, Chengying

    2012-01-01

    Programmable system-on-chip (PSoC), which provides a microprocessor and programmable analog and digital peripheral functions in a single chip, is very convenient for mixed-signal electronic system design. This paper presents the experience of teaching contemporary mixed-signal electronic system design with PSoC in the Department of Automation,…

  2. Innovative Bed Load Measurement System for Large Alpine Gravel-Bed Rivers

    NASA Astrophysics Data System (ADS)

    Seitz, H.; Habersack, H. M.

    2009-04-01

    Samplers, Birckbeck-type bed load traps, etc.- in this regard used as a calibration technique but in general independent and throughout accepted bed load measurement methods) could be obtained. Finally in 2006, the measurement equipment was enlarged to an integrative and innovative bed load measurement system by installing Geophones. In addition hydrological, geological, meteorological and other related data are collected. For further investigations there is a chance to test new measurement techniques under well known boundary conditions at the fully equipped gauging stations. The instrumentation will allow observing transport processes in detail within the study reach. Calibration Measurements take place during the rainfall and snow melting season from May to August, furthermore in November due to Genoa depressions causing heavy rainfall in the catchment area of the Drau River. Especially the initiation of motion, the bed load transport rate and bed load transport processes (cross sectional variation, periodicity in bed load movement) are analysed. Moreover, for understanding bed load transport processes the initiation of motion is of central importance. As a result it could be shown that the counted number of geophone impulses per unit time is proportional to the transported sediment volume, calculated out of direct bed load measurements and the associated flow discharge. The scatter between geophone impulses, caused by bed load transport fluctuations, and flow discharge can be reduced if the sum of geophone impulses is averaged over longer time intervals (time lag between moving gravel sheet maximums is about 25 minutes). Furthermore, the assumed spatial and temporal variability of the bed load movement could now be proven. In addition it could be proven, that commonly used bed load predictors underestimate the measured bed load transport. In conclusion the results of the investigation are showing new aspects for understanding bed load transport processes. The installed

  3. Innovative Structural and Joining Concepts for Lightweight Design of Heavy Vehicle Systems

    SciTech Connect

    Prucz, Jacky C; Shoukry, Samir N; William, Gergis W; Evans, Thomas H

    2006-09-30

    The extensive research and development effort was initiated by the U.S. Department of Energy (DOE) in 2002 at West Virginia University (WVU) in order to investigate practical ways of reducing the structural weight and increasing the durability of heavy vehicles through the judicious use of lightweight composite materials. While this project was initially focused on specific Metal Matrix Composite (MMC) material, namely Aluminum/Silicon Carbide (Al/SiC) commercially referenced as ''LANXIDE'', the current research effort was expanded from the component level to the system level and from MMC to other composite material systems. Broadening the scope of this research is warranted not only by the structural and economical deficiencies of the ''LANXIDE'' MMC material, but also by the strong coupling that exists between the material and the geometric characteristics of the structure. Such coupling requires a truly integrated design approach, focused on the heaviest sections of a van trailer. Obviously, the lightweight design methods developed in this study will not be implemented by the commercial industry unless the weight savings are indeed impressive and proven to be economically beneficial in the context of Life Cycle Costs (LCC). ''Bulk Haul'' carriers run their vehicles at maximum certified weight, so that each pound saved in structural weight would translate into additional pound of cargo, and fewer vehicles necessary to transport a given amount of freight. It is reasonable to ascertain that a typical operator would be ready to pay a premium of about $3-4 for every additional pound of cargo, or every pound saved in structural weight. The overall scope of this project is to devise innovative, lightweight design and joining concepts for heavy vehicle structures, including cost effective applications of components made of metal matrix composite (MMC) and other composite materials in selected sections of such systems. The major findings generated by this research effort

  4. Rethinking Communication in Innovation Processes: Creating Space for Change in Complex Systems

    ERIC Educational Resources Information Center

    Leeuwis, Cees; Aarts, Noelle

    2011-01-01

    This paper systematically rethinks the role of communication in innovation processes, starting from largely separate theoretical developments in communication science and innovation studies. Literature review forms the basis of the arguments presented. The paper concludes that innovation is a collective process that involves the contextual…

  5. Systems biology and systems genetics - novel innovative approaches to study host-pathogen interactions during influenza infection.

    PubMed

    Kollmus, Heike; Wilk, Esther; Schughart, Klaus

    2014-06-01

    Influenza represents a serious threat to public health with thousands of deaths each year. A deeper understanding of the host-pathogen interactions is urgently needed to evaluate individual and population risks for severe influenza disease and to identify new therapeutic targets. Here, we review recent progress in large scale omics technologies, systems genetics as well as new mathematical and computational developments that are now in place to apply a systems biology approach for a comprehensive description of the multidimensional host response to influenza infection. In addition, we describe how results from experimental animal models can be translated to humans, and we discuss some of the future challenges ahead.

  6. CASALUD: an innovative health-care system to control and prevent non-communicable diseases in Mexico.

    PubMed

    Tapia-Conyer, Roberto; Gallardo-Rincón, Héctor; Saucedo-Martinez, Rodrigo

    2015-07-01

    Mexico and other Latin American countries are currently facing a dramatic increase in the number of adults suffering from non-communicable diseases (NCDs) such as diabetes, cardiovascular disease (CVD) and chronic kidney disease (CKD), which require prolonged, continuous care. This epidemiological shift has created new challenges for health-care systems. Both the World Health Organization (WHO) and the United Nations (UN) have recognised the growing human and economic costs of NCDs and outlined an action plan, recognising that NCDs are preventable, often with common preventable risk factors linked to risky health behaviours. In line with international best practices, Mexico has applied a number of approaches to tackle these diseases. However, challenges remain for the Mexican health-care system, and in planning a strategy for combating and preventing NCDs, it must consider how best to integrate these strategies with existing health-care infrastructure. Shifting the paradigm of care in Mexico from a curative, passive approach to a preventive, proactive model will require an innovative and replicable system that guarantees availability of medicines and services, strengthens human capital through ongoing professional education, expands early and continuous access to care through proactive prevention strategies and incorporates technological innovations in order to do so. Here, we describe CASALUD: an innovative model in health-care that leverages international best practices and uses innovative technology to deliver NCD care, control and prevention. In addition, we describe the lessons learned from the initial implementation of the model for its effective use in Mexico, as well as the plans for wider implementation throughout the country, in partnership with the Mexican Ministry of Health.

  7. Innovative Structural and Joining Concepts for Lightweight Design of Heavy Vehicle Systems

    SciTech Connect

    Jacky C. Prucz; Samir N. Shoukry; Gergis W. William

    2005-08-31

    vehicles. The research work planed for the first year of this project (June 1, 2003 through May 30, 2004) focused on a theoretical investigation of weight benefits and structural performance tradeoffs associated with the design, fabrication, and joining of MMC components for heavy-duty vehicles. This early research work conducted at West Virginia University yielded the development of integrated material-structural models that predicted marginal benefits and significant barriers to MMC applications in heavy trailers. The results also indicated that potential applications of MMC materials in heavy vehicles are limited to components identified as critical for either loadings or weight savings. Therefore, the scope of the project was expanded in the following year (June 1, 2004 through May 30, 2005) focused on expanding the lightweight material-structural design concepts for heavy vehicles from the component to the system level. Thus, the following objectives were set: (1) Devise and evaluate lightweight structural configurations for heavy vehicles. (2) Study the feasibility of using Metal Matrix Composites (MMC) for critical structural components and joints in heavy vehicles. (3) Develop analysis tools, methods, and validated test data for comparative assessments of innovative design and joining concepts. (4) Develop analytical models and software for durability predictions of typical heavy vehicle components made of particulate MMC or fiber-reinforced composites. This report summarizes the results of the research work conducted during the past two years in this projects.

  8. Managerial innovation in the hospital: an analysis of the diffusion of hospital cost-accounting systems.

    PubMed

    Counte, M A; Glandon, G L

    1988-01-01

    Currently much interest is focused on the uses of cost-accounting systems within the hospital industry. Proponents frequently contend that such systems will help hospitals successfully adapt to new methods of financial reimbursement because they are essential to a number of major management functions, including competitive bidding, cost management, pricing, and profitability assessment. This article reports the results of a study conducted to examine the extent to which hospitals in a major market are actually beginning to use standard cost-accounting systems and identify factors that either aid or hinder the diffusion of these methods. Chief financial officers from 94 hospitals (83 percent response rate) participated in the study during the summer of 1986 where less than half of the hospitals (43 percent) had recently purchased a cost-accounting system. Detailed information about the interface of cost-accounting systems with other application systems and their specific management uses is reported.

  9. Controlled release bactericide: An innovative system to control acid mine drainage

    SciTech Connect

    Sobek, A.A.; Rastogi, V.

    1986-01-01

    Controlled release systems delivering the required concentration of an effective bactericide over an extended time period have been developed by the BF Goodrich Company's ProMac Systems group. The ProMac system is site-specific and includes a four-step approach to controlling acid mine drainage (AMD): (1) Diagnosing the problem, (2) Prescribing the treatment, (3) Supervising the application of controlled release bactericides, and (4) Monitoring the success of applied treatment. The success of the ProMac system is evidenced by improved water quality, healthy vegetation, a reduction in levels of acidophilic thiobacillus, and a corresponding increase in population of beneficial microorganisms.

  10. Innovative Imagery System for Enhanced Habitability Onboard ISS: Desired Features and Possible Hardware Applications

    NASA Technical Reports Server (NTRS)

    Whitmore, Mihriban; Baggerman, Susan; Byrne, Vicky

    2004-01-01

    With the advent of the ISS and the experience of Russian, European, and US crewmembers on Mir, the importance of the psychological element in long duration missions is increasingly recognized. An integrated imagery system or Magic Window System could enhance the habitability, performance, and productivity for long term stays in space. Because this is type of system is a new concept for space, functional and technical requirements need to be determined. As part of a three-year project, the functional and technical requirements for an Imagery System onboard the International Space Station (ISS) have been explored. Valuable information was gathered from a survey completed by participants that had been in analog environments (remote/isolated) such as Antarctica, Aquarius, ISS crewmember debriefs, and crew support meetings to identify key functions desired for an integrated Magic Window System. Exercise and medical care activities were identified as areas that could benefit from such a system. It was determined that for exercise, it was worth exploring the concept of displaying a dynamic screen that changes as the crewmember's speed changes while showing physiological measures in a combined display. In terms of enhancing the interfaces for medical care activities, the Magic Window System could show video clips along side procedures for just-in-time training scenarios through a heads-up display. In addition, the portability, usability, and reliability were stressed as important considerations for an integrated system of technologies or Magic Window System. In addition, a review of state-of-the-art screens and other existing technologies such as tablet PCs and Personal Digital Assistants (PDAs) was conducted and contributed to defining technical requirements and feasibility of systems. Some heuristic evaluations of large displays and PDAs were conducted. Finally, feasibility for implementation onboard ISS has been considered. Currently, specific headset units are

  11. FGD system capital and operating cost reductions based on improved thiosorbic scrubber system design and latest process innovations

    SciTech Connect

    Smith, K.; Tseng, S.; Babu, M.

    1994-12-31

    Dravo Lime Company has operated the Miami Fort wet scrubber FGD pilot test unit since late 1989 and has continued in-house R&D to improve the economics of the magnesium-enhanced scrubbing process. Areas investigated include the scrubber configuration, flue gas velocity, spray nozzle type, droplet size, mist eliminator design, additives to inhibit oxidation, improved solids dewatering, etc. Also tested was the forced oxidation Thioclear process. The data gathered from the pilot plant and in-house programs were used to evaluate the capital and operating costs for the improved systems. These evaluations were made with eye towards the choices electric utilities will need to make in the near future to meet the Phase II emission limits mandated by the 1990 Clean Air Act. Some of the process modifications investigated, for example, the dewatering improvements apply to potential beneficial retrofit of existing FGD systems today.

  12. Narrative change in emotion-focused therapy: how is change constructed through the lens of the innovative moments coding system?

    PubMed

    Mendes, Inês; Ribeiro, António P; Angus, Lynne; Greenberg, Leslie S; Sousa, Inês; Gonçalves, Miguel M

    2010-11-01

    The aim of this study was to advance understanding of how clients construct their own process of change in effective therapy sessions. Toward this end, the authors applied a narrative methodological tool for the study of the change process in emotion-focused therapy (EFT), replicating a previous study done with narrative therapy (NT). The Innovative Moments Coding System (IMCS) was applied to three good-outcome and three poor-outcome cases in EFT for depression to track the innovative moments (IMs), or exceptions to the problematic self-narrative, in the therapeutic conversation. IMCS allows tracking of five types of IMs events: action, reflection, protest, reconceptualization, and performing change. The analysis revealed significant differences between the good-outcome and poor-outcome groups regarding reconceptualization and performing change IMs, replicating the findings from a previous study. Reconceptualization and performing change IMs seem to be vital in the change process. PMID:21154027

  13. Innovative Business Cases for Energy Storage In a Restructured Electricity Marketplace, A Study for the DOE Energy Storage Systems Program

    SciTech Connect

    IANNUCCI, JOE; EYER, JIM; BUTLER, PAUL C.

    2003-02-01

    This report describes the second phase of a project entitled ''Innovative Business Cases for Energy Storage in a Restructured Electricity Marketplace''. During part one of the effort, nine ''Stretch Scenarios'' were identified. They represented innovative and potentially significant uses of electric energy storage. Based on their potential to significantly impact the overall energy marketplace, the five most compelling scenarios were identified. From these scenarios, five specific ''Storage Market Opportunities'' (SMOs) were chosen for an in-depth evaluation in this phase. The authors conclude that some combination of the Power Cost Volatility and the T&D Benefits SMOs would be the most compelling for further investigation. Specifically, a combination of benefits (energy, capacity, power quality and reliability enhancement) achievable using energy storage systems for high value T&D applications, in regions with high power cost volatility, makes storage very competitive for about 24 GW and 120 GWh during the years of 2001 and 2010.

  14. COST EFFECTIVE VOC EMISSION CONTROL STARTEGIES FOR MILITARY, AEROSPACE,AND INDUSTRIAL PAINT SPRAY BOOTH OPERATIONS: COMBINING IMPROVED VENTILATION SYSTEMS WITH INNOVATIVE, LOW COST EMISSION CONTROL TECHNOLOGIES

    EPA Science Inventory

    The paper describes a full-scale demonstration program in which several paint booths were modified for recirculation ventilation; the booth exhaust streams are vented to an innovative volatile organic compound (VOC) emission control system having extremely low operating costs. ...

  15. Use of Bibliographic Systems and Concept Maps: Innovative Tools to Complete a Literature Review

    ERIC Educational Resources Information Center

    Martelo, Maira L.

    2011-01-01

    This article presents a process for utilizing a bibliographic system built with Microsoft Excel as well as concept maps to organize and to synthesize information that can be included in a literature review. A review of the conceptual framework behind these tools is included as well as a detailed description about how to build the system in Excel.…

  16. An innovative seismic bracing system based on a superelastic shape memory alloy ring

    NASA Astrophysics Data System (ADS)

    Gao, Nan; Jeon, Jong-Su; Hodgson, Darel E.; DesRoches, Reginald

    2016-05-01

    Shape memory alloys (SMAs) have great potential in seismic applications because of their remarkable superelasticity. Seismic bracing systems based on SMAs can mitigate the damage caused by earthquakes. The current study investigates a bracing system based on an SMA ring which is capable of both re-centering and energy dissipation. This lateral force resisting system is a cross-braced system consisting of an SMA ring and four tension-only cable assemblies, which can be applied to both new construction and seismic retrofit. The performance of this bracing system is examined through a quasi-static cyclic loading test and finite element (FE) analysis. This paper describes the experimental design in detail, discusses the experimental results, compares the performance with other bracing systems based on SMAs, and presents an Abaqus FE model calibrated on the basis of experimental results to simulate the superelastic behavior of the SMA ring. The experimental results indicate that the seismic performance of this system is promising in terms of damping and re-centering. The FE model can be used in the simulation of building structures using the proposed bracing system.

  17. Innovative cross-flow membrane system for volume reduction of mixed waste

    SciTech Connect

    Greene, W.

    1997-10-01

    In this task, SpinTek Membrane Systems, Inc., and the Institute of Gas Technology are completing engineering development leading to a full-scale demonstration of the SpinTek ST-II High Shear Rotary Membrane Filtration System (ST-II) under a Program Research and Development Agreement (PRDA) with the Federal Energy Technology Center-Morgantown. The SpinTek ST-II technology will be scaled-up, and a two-stage ST-II system will be designed, constructed, and operated on both surrogate and actual feed at the Los Alamos National Laboratory (LANL) Liquid Radioactive Waste Treatment Facility (LRWTF). Results from these studies on both surrogate and actual wastewater streams will also be used by LANL personnel to produce a model for determining the applicability and economics of the SpinTek ST-II system to other DOE waste and process streams. The ST-II is a unique, compact cross-flow membrane system having several advantages in performance and cost compared to currently available systems. Staff at LANL have performed pilot-scale testing with the SpinTek technology to evaluate its feasibility for enhanced radionuclide removal from wastewater at its 5- to 8-million-gallon-per-year LRWTF. Recent data have shown the system`s capabilities to remove radionuclides from the waste stream at concentration factors greater than 2000:1, and performance has exceeded both conventional and all other advanced technologies examined.

  18. Innovation in user-centered skills and performance improvement for sustainable complex service systems.

    PubMed

    Karwowski, Waldemar; Ahram, Tareq Z

    2012-01-01

    In order to leverage individual and organizational learning and to remain competitive in current turbulent markets it is important for employees, managers, planners and leaders to perform at high levels over time. Employee competence and skills are extremely important matters in view of the general shortage of talent and the mobility of employees with talent. Two factors emerged to have the greatest impact on the competitiveness of complex service systems: improving managerial and employee's knowledge attainment for skills, and improving the training and development of the workforce. This paper introduces the knowledge-based user-centered service design approach for sustainable skill and performance improvement in education, design and modeling of the next generation of complex service systems. The rest of the paper cover topics in human factors and sustainable business process modeling for the service industry, and illustrates the user-centered service system development cycle with the integration of systems engineering concepts in service systems. A roadmap for designing service systems of the future is discussed. The framework introduced in this paper is based on key user-centered design principles and systems engineering applications to support service competitiveness. PMID:22317322

  19. Investigating properties of the cardiovascular system using innovative analysis algorithms based on ensemble empirical mode decomposition.

    PubMed

    Yeh, Jia-Rong; Lin, Tzu-Yu; Chen, Yun; Sun, Wei-Zen; Abbod, Maysam F; Shieh, Jiann-Shing

    2012-01-01

    Cardiovascular system is known to be nonlinear and nonstationary. Traditional linear assessments algorithms of arterial stiffness and systemic resistance of cardiac system accompany the problem of nonstationary or inconvenience in practical applications. In this pilot study, two new assessment methods were developed: the first is ensemble empirical mode decomposition based reflection index (EEMD-RI) while the second is based on the phase shift between ECG and BP on cardiac oscillation. Both methods utilise the EEMD algorithm which is suitable for nonlinear and nonstationary systems. These methods were used to investigate the properties of arterial stiffness and systemic resistance for a pig's cardiovascular system via ECG and blood pressure (BP). This experiment simulated a sequence of continuous changes of blood pressure arising from steady condition to high blood pressure by clamping the artery and an inverse by relaxing the artery. As a hypothesis, the arterial stiffness and systemic resistance should vary with the blood pressure due to clamping and relaxing the artery. The results show statistically significant correlations between BP, EEMD-based RI, and the phase shift between ECG and BP on cardiac oscillation. The two assessments results demonstrate the merits of the EEMD for signal analysis.

  20. Innovation in user-centered skills and performance improvement for sustainable complex service systems.

    PubMed

    Karwowski, Waldemar; Ahram, Tareq Z

    2012-01-01

    In order to leverage individual and organizational learning and to remain competitive in current turbulent markets it is important for employees, managers, planners and leaders to perform at high levels over time. Employee competence and skills are extremely important matters in view of the general shortage of talent and the mobility of employees with talent. Two factors emerged to have the greatest impact on the competitiveness of complex service systems: improving managerial and employee's knowledge attainment for skills, and improving the training and development of the workforce. This paper introduces the knowledge-based user-centered service design approach for sustainable skill and performance improvement in education, design and modeling of the next generation of complex service systems. The rest of the paper cover topics in human factors and sustainable business process modeling for the service industry, and illustrates the user-centered service system development cycle with the integration of systems engineering concepts in service systems. A roadmap for designing service systems of the future is discussed. The framework introduced in this paper is based on key user-centered design principles and systems engineering applications to support service competitiveness.

  1. Engineering America's Current and Future Space Transportation Systems: 50 Years of Systems Engineering Innovation for Sustainable Exploration

    NASA Technical Reports Server (NTRS)

    Dmbacher, Daniel L.; Lyles, Garry M.; McConnaughey, Paul

    2008-01-01

    Over the past 50 years, the National Aeronautics and Space Administration (NASA) has delivered space transportation solutions for America's complex missions, ranging from scientific payloads that expand knowledge, such as the Hubble Space Telescope, to astronauts and lunar rovers destined for voyages to the Moon. Currently, the venerable Space Shuttle, which has been in service since 1981, provides the United States' (U.S.) capability for both crew and heavy cargo to low-Earth orbit to' construct the International Space Station, before the Shuttle is retired in 2010. In the next decade, NASA will replace this system with a duo of launch vehicles: the Ares I Crew Launch Vehicle and the Ares V Cargo Launch Vehicle (Figure 1). The goals for this new system include increased safety and reliability coupled with lower operations costs that promote sustainable space exploration for decades to come. The Ares I will loft the Orion Crew Exploration Vehicle, while the heavy-lift Ares V will carry the Altair Lunar Lander and the equipment and supplies needed to construct a lunar outpost for a new generation of human and robotic space pioneers. This paper will provide details of the in-house systems engineering and vehicle integration work now being performed for the Ares I and planned for the Ares V. It will give an overview of the Ares I system-level test activities, such as the ground vibration testing that will be conducted in the Marshall Center's Dynamic Test Stand to verify the integrated vehicle stack's structural integrity and to validate computer modeling and simulation (Figure 2), as well as the main propulsion test article analysis to be conducted in the Static Test Stand. These activities also will help prove and refine mission concepts of operation, while supporting the spectrum of design and development work being performed by Marshall's Engineering Directorate, ranging from launch vehicles and lunar rovers to scientific spacecraft and associated experiments

  2. Development of an Innovative Direct Push Sensor System for Long Term Monitoring of Environmental Waste Sites

    NASA Astrophysics Data System (ADS)

    Eddy-Dilek, C. A.; Riha, B. D.; Bosze, S.; Rossabi, J.

    2001-12-01

    As the focus of environmental restoration in the federal complex moves from active characterization and remediation to long term monitoring, the costs of long-term monitoring will escalate and eventually dominate ongoing environmental restoration budgets. Most of the major DOE sites including the Savannah River Site have a documented need for some type of long term monitoring system that does not rely on the use of standard groundwater monitoring wells. We have developed and installed a prototype monitoring system that can be used to measure and/or sample multiple parameters appropriate for long term monitoring of environmental waste sites. This system is designed to function as a sentinel system that detects when a significant change in water quality parameters or contaminant concentration occurs in a well characterized system. The sensor drive configuration is flexible and the sensor system is installed using direct push methods. Site specific monitoring scenarios will be need to be developed to address the specific long term monitoring objectives at a given site. The drive point has a sample port (soil gas or groundwater) and windows/ports for additional sensors. A prototype system was installed and has been monitored at the D-area at the Savannah River Site since July. The probes are located in an area where multiple contaminant plumes dominated by volatile organic compounds, metals and tritium are currently monitored using standard groundwater wells. Currently, the prototype system measures temperature, resisitivity, ORP and pH on a continuous basis. In addition, concetrations of volatile organic compounds and tritium are measured periodically by laboratory analysis of diffusion bag samples deployed in the sample ports of the prototype system. Results will be reported from a three-month monitoring interval. The results will be compared with baseline analyses of samples collected from the adjacent groundwater well.

  3. The era of micro and nano systems in the biomedical area: bridging the research and innovation gap.

    PubMed

    Lymberis, A

    2011-01-01

    The area of Micro and Nano systems (MNS) focuses on heterogeneous integration of technologies (e.g. electronics, mechanics and biotechnology) and implementation of multiple functionalities (e.g. sensing, processing, communication, energy and actuation) into small systems. A significant amount of MNS activities targets development and testing of systems enabling biomedicine and personal health solutions. Convergence of micro-nano-bio and Information & communication technologies is being leading to enabling innovative solutions e.g. for in-vitro testing and in vivo interaction with the human body for early diagnosis and minimally invasive therapy. Of particular interest are smart wearable systems such as smart textiles aiming at the full integration of sensors/actuators, energy sources, processing and communication within the clothes to enable non-invasive personal health, lifestyle, safety and emergency applications. The paper presents on going major R&D activities on micro-nano-bio systems (MNBS) and wearable systems for pHealth under the European Union R&D Programs, Information and Communication Technologies (ICT) priority; it also identifies gaps and discusses key challenges for the future. PMID:22254616

  4. Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure.

    PubMed

    Zhang, Chungang; Tang, Jingya; Liu, Dechun; Li, Xuetao; Cheng, Lan; Tang, Xing

    2016-04-30

    In this study a gastric-retentive delivery system was prepared by a novel method which is reported here for the first time. An innovative floating and bioadhesive drug delivery system with a hollow structure was designed and prepared. The floating and bioadhesive drug delivery system was composed of a hollow spherical shell, a waterproof layer (Stearic acid), a drug layer (Ofloxacin), a release retarding film (the novel blended coating materials) and a bioadhesive layer (Carbomer 934P) prepared by using a liquid multi-layering process. A novel blended coating material was designed and investigated to solve the problem of the initial burst release of the formulation and the release mechanism of the novel material was analyzed in this study. The optimized formulation provided the sustained release characteristic and was able to float for 24h. The SEM cross-section images showed that the particulates were hollow with a spherical shell. X-ray images and pharmacokinetic studies (Frel = 124.1 ± 28.9%) in vivo showed that the gastric-retentive delivery system can be retained in the stomach for more than 6h. The floating and bioadhesive particulate drug delivery system based on a hollow structure with a dual function presented here is a viable alternative to other for gastroretentive drug delivery system. PMID:26943975

  5. WSN system design by using an innovative neural network model to perform thermals forecasting in a urban canyon scenario

    NASA Astrophysics Data System (ADS)

    Giuseppina, Nicolosi; Salvatore, Tirrito

    2015-12-01

    Wireless Sensor Networks (WSNs) were studied by researchers in order to manage Heating, Ventilating and Air-Conditioning (HVAC) indoor systems. WSN can be useful specially to regulate indoor confort in a urban canyon scenario, where the thermal parameters vary rapidly, influenced by outdoor climate changing. This paper shows an innovative neural network approach, by using WSN data collected, in order to forecast the indoor temperature to varying the outdoor conditions based on climate parameters and boundary conditions typically of urban canyon. In this work more attention will be done to influence of traffic jam and number of vehicles in queue.

  6. Skeletally Diverse Synthesis of Innovative [2,1-c]-1,4-Oxazepine and [1,4]-Quinoxaline Systems.

    PubMed

    Lee, Chia-Hsin; Wu, Wen-Chun; Dangate, Prasad S; Shen, Li-Ching; Chung, Wen-Sheng; Sun, Chung-Ming

    2015-10-12

    An efficient, innovative synthesis of [2,1-c]-1, 4-oxazepine and [1,4]-quinoxaline heterocycles along with the embodied pyrimido-pyrrolo motifs was established. Initially, the pyrrole ring was installed using microwave irradiation through an intramolecular base-catalyzed cyclization between acetyl bromomethyl pyrimidine dione and o-amino phenyl methanol or o-phenylenediamine methyl benzoates. Furthermore, oxazepine, and quinoxaline scaffolds were constructed by an acid-catalyzed condensation with a variety of aldehydes by an unconventional Pictet-Spengler reaction strategy. An important aspect of this work is to build novel heterocyclic ring systems with potential medicinal interest.

  7. Skeletally Diverse Synthesis of Innovative [2,1-c]-1,4-Oxazepine and [1,4]-Quinoxaline Systems.

    PubMed

    Lee, Chia-Hsin; Wu, Wen-Chun; Dangate, Prasad S; Shen, Li-Ching; Chung, Wen-Sheng; Sun, Chung-Ming

    2015-10-12

    An efficient, innovative synthesis of [2,1-c]-1, 4-oxazepine and [1,4]-quinoxaline heterocycles along with the embodied pyrimido-pyrrolo motifs was established. Initially, the pyrrole ring was installed using microwave irradiation through an intramolecular base-catalyzed cyclization between acetyl bromomethyl pyrimidine dione and o-amino phenyl methanol or o-phenylenediamine methyl benzoates. Furthermore, oxazepine, and quinoxaline scaffolds were constructed by an acid-catalyzed condensation with a variety of aldehydes by an unconventional Pictet-Spengler reaction strategy. An important aspect of this work is to build novel heterocyclic ring systems with potential medicinal interest. PMID:26379108

  8. Single event and TREE latchup mitigation for a star tracker sensor: An innovative approach to system level latchup mitigation

    SciTech Connect

    Kimbrough, J.R.; Colella, N.J.; Davis, R.W.; Bruener, D.B.; Coakley, P.G.; Lutjens, S.W.; Mallon, C.E.

    1994-08-01

    Electronic packages designed for spacecraft should be fault-tolerant and operate without ground control intervention through extremes in the space radiation environment. If designed for military use, the electronics must survive and function in a nuclear radiation environment. This paper presents an innovative ``blink`` approach rather than the typical ``operate through`` approach to achieve system level latchup mitigation on a prototype star tracker camera. Included are circuit designs, flash x-ray test data, and heavy ion data demonstrating latchup mitigation protecting micro-electronics from current latchup and burnout due to Single Event Latchup (SEL) and Transient Radiation Effects on Electronics (TREE).

  9. The Canadian Hospitals Injury Reporting and Prevention Program: a dynamic and innovative injury surveillance system

    PubMed Central

    Crain, J.; McFaull, S.; Thompson, W.; Skinner, R.; Do, M. T.; Fréchette, M.; Mukhi, S.

    2016-01-01

    Abstract This status report on the Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP), an emergency department-based injury and poisoning surveillance system, describes the result of migrating from a centralized data entry and coding process to a decentralized process, the web-based eCHIRPP system, in 2011. This secure system is improving the CHIRPP’s overall flexibility and timeliness, which are key attributes of an effective surveillance system. The integrated eCHIRPP platform enables near real-time data entry and access, has user-friendly data management and analysis tools, and allows for easier communication and connectivity across the CHIRPP network through an online collaboration centre. Current pilot testing of automated data monitoring and trend analysis tools—designed to monitor and flag incoming data according to predefined criteria (for example, a new consumer product)—is revealing eCHIRPP’s potential for providing early warnings of new hazards, issues and trends. PMID:27284703

  10. Innovative open air brayton combined cycle systems for the next generation nuclear power plants

    NASA Astrophysics Data System (ADS)

    Zohuri, Bahman

    The purpose of this research was to model and analyze a nuclear heated multi-turbine power conversion system operating with atmospheric air as the working fluid. The air is heated by a molten salt, or liquid metal, to gas heat exchanger reaching a peak temperature of 660 0C. The effects of adding a recuperator or a bottoming steam cycle have been addressed. The calculated results are intended to identify paths for future work on the next generation nuclear power plant (GEN-IV). This document describes the proposed system in sufficient detail to communicate a good understanding of the overall system, its components, and intended uses. The architecture is described at the conceptual level, and does not replace a detailed design document. The main part of the study focused on a Brayton --- Rankine Combined Cycle system and a Recuperated Brayton Cycle since they offer the highest overall efficiencies. Open Air Brayton power cycles also require low cooling water flows relative to other power cycles. Although the Recuperated Brayton Cycle achieves an overall efficiency slightly less that the Brayton --- Rankine Combined Cycle, it is completely free of a circulating water system and can be used in a desert climate. Detailed results of modeling a combined cycle Brayton-Rankine power conversion system are presented. The Rankine bottoming cycle appears to offer a slight efficiency advantage over the recuperated Brayton cycle. Both offer very significant advantages over current generation Light Water Reactor steam cycles. The combined cycle was optimized as a unit and lower pressure Rankine systems seem to be more efficient. The combined cycle requires a lot less circulating water than current power plants. The open-air Brayton systems appear to be worth investigating, if the higher temperatures predicted for the Next Generation Nuclear Plant do materialize.

  11. Multi-user satellite communications system using an innovative compressive receiver

    NASA Technical Reports Server (NTRS)

    Staples, Edward J.

    1992-01-01

    There is a need for an onboard simultaneous multi-channel demodulation system for a satellite communications system. Studies indicate that Convolve Multiply Convolve (CMC) filtering with surface acoustic wave (SAW) dispersive delay lines will eliminate the necessity of onboard satellite channelized filters of complex fourier transform processors. The reason for choosing the CMC technique is its ability to perform Fourier transformations in a shorter time with less space and power consumption than digital Fourier transform processors. Each ground terminal in this multi-users communications system is remotely located and operates independently; hence, a method of synchronizing the transmission of these users is presented which utilizes the existing Global Positioning System (GPS) system. Each ground user is equipped with a low cost ground terminal that has a synchronization subsystem attached to it. The system design of an onboard Multi-channel Receiver and Demodulator utilizes Quadrature Phase Shift Keying (QPSK) as the modulation technique. This technique provides the best figure of merit, i.e., the lowest transmitter power requirement per communication channel.

  12. Innovative Internal Camera Inspection and Data Management for Effective Condition Assessment of Collection Systems

    EPA Science Inventory

    The primary objective of this guidance document is to identify and evaluate innovative closed-circuit television (CCTV) and related technologies currently used by more advanced wastewater utilities to conduct condition assessment programs. The document is intended to facilitate ...

  13. GEOTECH, INC., COLD TOP EX-SITU VITRIFICATION SYSTEM; INNOVATIVE TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    A Superfund Innovative Technology Evaluation (SITE) technology demonstration was conducted in February and March 1997 to evaluate the Geotech Development Corporation (Geotech) Cold Top ex-situ vitrification technology in chromium-contaminated soils. The demonstration was conduct...

  14. Building America Top Innovations 2012: Integration of HVAC System Design with Simplified Duct Distribution

    SciTech Connect

    none,

    2013-01-01

    This Building America Top Innovations profile describes work by Building America research teams who field tested simplified duct designs in hundreds of homes, confirming the performance of short compact duct runs, with supply registers near interior walls.

  15. Determining accessibility to dermatologists and teledermatology locations in Kentucky: demonstration of an innovative geographic information systems approach.

    PubMed

    Shannon, Gary William; Buker, Carol Marie

    2010-01-01

    Teledermatology provides a partial solution to the problem of accessibility to dermatology services in underserved areas, yet methodologies to determine the locations and geographic dimensions of these areas and the locational efficiency of remote teledermatology sites have been found wanting. This article illustrates an innovative Geographic Information Systems approach using dermatologists' addresses, U.S. Census population data, and the Topologically Integrated Geographic Encoding and Referencing System. Travel-time-based service areas were calculated and mapped for each dermatologist in the state of Kentucky and for possible locations of several remote teledermatology sites. Populations within the current and possible remote service areas were determined. These populations and associated maps permit assessment of the locational efficiency of the current distribution of dermatologists, location of underserved areas, and the potential contribution of proposed hypothetical teledermatology sites. This approach is a valuable and practical tool for evaluating access to current distributions of dermatologists as well as planning for and implementing teledermatology.

  16. An innovative fixed-pole numerical approximation for fractional order systems.

    PubMed

    Wei, Yiheng; Tse, Peter W; Du, Bin; Wang, Yong

    2016-05-01

    A novel numerical approximation scheme is proposed for fractional order systems by the concept of identification. An identical equation is derived firstly, from which one can obtain the exact state space model of fractional order systems. It reveals the nature of the approximation problem, and then provides an effective scheme to obtain the desired model. This research project also focuses on solving a knotty but crucial issue, i.e., the initial value problem of fractional order systems. The results generated by the study prove that it can reduce to the Caputo case by selecting some specific initial values. A careful simulation study is reported to illustrate the effectiveness of the proposed scheme. To exhibit the superiority clearly, the results are compared with that of the published fixed-pole finite model method.

  17. Unleaded gasoline in the United States; A successful model of system innovation

    SciTech Connect

    Sperling, D.; Dill, J. )

    1988-01-01

    This paper reports on the introduction of unleaded gasoline and catalyst-equipped vehicles that required numerous changes in U.S. transportation and energy systems. Simultaneous technological and operational changes in fuel production, distribution, and end-use systems had to be made, and the inherent resistance to change that characterizes complex sociotechnical systems had to be overcome. The transition to unleaded gasoline was unique in that it was instigated and orchestrated by federal rules and laws; market forces did not play a direct or major role. This government-orchestrated transition serves as a possible model for other countries that are contemplating the phasing out of lead in gasoline and, more generally, as a model for the United States and other countries for the introduction of non-petroleum fuels.

  18. BOA II: Asbestos Pipe-Insulation Removal Robot System. Innovative Technology Summary Report.

    SciTech Connect

    2001-09-01

    The objective of this task is to develop and demonstrate a mechanical, asbestos-removal system that can be remotely operated without a containment area. The technology, known as BOA, consists of a pipe-crawler removal head and a boom vehicle system with dual robots. BOA's removal head can be remotely placed on the outside of the pipe and can crawl along the pipe, removing lagging and insulation. The lagging and insulation is cut using a hybrid endmill water-jet cutter and then diced into 2-inch cube sections of ACM. These ACM sections are then removed from the pipe using a set of blasting fan- spray nozzles, vacuumed off through a vacuum hose, and bagged. Careful attention to vacuum and entrapment air flow ensures that the system can operate without a containment area while meeting local and federal standards for fiber count.

  19. Development and Demonstration of an Innovative Thermal Energy Storage System for Baseload Power Generation

    SciTech Connect

    Goswami, D. Yogi

    2012-09-04

    The objective of this project is to research and develop a thermal energy storage system (operating range 300°C - 450°C) based on encapsulated phase change materials (PCM) that can meet the utility-scale base-load concentrated solar power plant requirements at much lower system costs compared to the existing thermal energy storage (TES) concepts. The major focus of this program is to develop suitable encapsulation methods for existing low-cost phase change materials that would provide a cost effective and reliable solution for thermal energy storage to be integrated in solar thermal power plants. This project proposes a TES system concept that will allow for an increase of the capacity factor of the present CSP technologies to 75% or greater and reduce the cost to less than $20/kWht.

  20. Field evaluation of an innovative stormwater treatment device--the Stormvault system.

    PubMed

    Zhang, Ru; Zhou, Wen Bin; Li, Jing; Yu, Shaw L

    2010-10-01

    Stormvault is a new volume-control-based underground stormwater treatment system, which is well suited for implementation in urban areas. In order to evaluate the hydrologic and hydraulic function of the system and assess the pollutant removal capacity of the system, a field monitoring program was implemented during both wet and dry weather conditions for 2 years. The pollutants of interest were total suspended solids (TSS), chemical oxygen demand (COD), total phosphorus (TP), and orthophosphate (OP). Data of 35 storms obtained were then analyzed by using several methods, such as the efficiency ratios, the summation of loads, and the relative achievable efficiency (RAE) methods to obtain estimates for the pollutant removal efficiencies of the Stormvault unit. Results show the following average efficiencies: TSS 82.46%, COD 73.10%, TP 47.37%, and OP 52.54%. Statistical significance and variation of removal efficiency with inlet concentration were also examined.

  1. A robo-pigeon based on an innovative multi-mode telestimulation system.

    PubMed

    Yang, Junqing; Huai, Ruituo; Wang, Hui; Lv, Changzhi; Su, Xuecheng

    2015-01-01

    In this paper, we describe a new multi-mode telestimulation system for brain-microstimulation for the navigation of a robo-pigeon, a new type of bio-robot based on Brain-Computer Interface (BCI) techniques. The multi-mode telestimulation system overcomes neuron adaptation that was a key shortcoming of the previous single-mode stimulation by the use of non-steady TTL biphasic pulses accomplished by randomly alternating pulse modes. To improve efficiency, a new behavior model ("virtual fear") is proposed and applied to the robo-pigeon. Unlike the previous "virtual reward" model, the "virtual fear" behavior model does not require special training. The performance and effectiveness of the system to alleviate the adaptation of neurons was verified by a robo-pigeon navigation test, simultaneously confirming the practicality of the "virtual fear" behavioral model.

  2. Acid Mine Drainage Research in Gauteng Highlighting Impacts on Infrastructure and Innovation of Concrete-Based Remedial Systems

    NASA Astrophysics Data System (ADS)

    Diop, S.; Ekolu, S.; Azene, F.

    2013-12-01

    Acid mine drainage (AMD) is presently one of the most important environmental problems in in the densely populated Gauteng Province, South Africa. The threat of acid mine drainage has demanded short-term interventions (some of which are being implemented by government) but more importantly sustainable long-term innovative solutions. There have been moments of public apprehension with some media reports dubbing the current scenario as a future 'nightmare of biblical proportions' and 'South Africa's own Chernobyl' that could cause dissolving of concrete foundations of buildings and reinforcement steel, leading to collapse of structures. In response to the needs of local and provincial authorities, this research was conducted to (1) generate scientific understanding of the effects of AMD on infrastructure materials and structures, and (2) propose innovative long-term remedial systems based on cementitious materials for potential AMD treatment applications of engineering scale. Two AMD solutions from the goldfields and two others from the coalfields were used to conduct corrosion immersion tests on mild steel, stainless steel, mortars, pastes and concretes. Results show that AMD water from the gold mines is more corrosive than that from the coal mines, the corrosion rate of the former being about twice that of the latter. The functionality of metal components of mild steel can be expected to fail within one month of exposure to the mine water. The investigation has also led to development of a pervious concrete filter system of water-cement ratio = 0.27 and cement content = 360 kg/m3, to be used as a permeable reactive barrier for AMD treatment. Early results show that the system was effective in removing heavy metal contaminants with removal levels of 30% SO4, 99% Fe, 50-83% Mn, 85% Ca, and 30% TDS. Further work is on-going to improve and optimise the system prior to field demonstration studies.

  3. INNOVATIVE APPROACHES TO COMPLYING WITH VERY LOW NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM (NPDES) PERMIT LIMITS FOR METALS

    SciTech Connect

    Payne, B

    2009-06-26

    The NPDES permit issued to the Savannah River Site (SRS) in 2003 contained very low metals limits for several outfalls. Copper, lead and zinc limits were as low as seven micrograms per liter (7 ug/l), 1 ug/l, and 100 ug/l, respectively. The permit contained compliance schedules that provided SRS with only three to five years to select and implement projects that would enable outfall compliance. Discharges from a few outfalls were eliminated or routed into other locations relatively inexpensively. However, some outfall problems were much more difficult to correct. SRS personnel implemented several innovative projects in order to meet compliance schedule deadlines as inexpensively as possible. These innovations included (1) connecting several outfall discharges to the site's Central Sanitary Wastewater Treatment Facility (CSWTF), (2) constructing a treatment wetlands and completing a water-effects ratio (WER) on its effluent, (3) installing a stannous chloride feed system to remove mercury in an existing air stripper, and (4) constructing a humic acid feed system to increase effluent dissolved organic carbon (DOC) content and take advantage of biotic ligand modeling to raise effluent limits.

  4. Remotely Operated Vehicle (ROV) System for Horizontal Tanks. Innovative Technology Summary Report

    SciTech Connect

    2001-05-01

    The U.S. Department of Energy (DOE) is responsible for cleaning and closing over 300 small and large underground tanks across the DOE complex that are used for storing over 1-million gal of high- and low-level radioactive and mixed waste (HLW, LLW, and MLLW). The contents of these aging tanks must be sampled to analyze for contaminants to determine final disposition of the tank and its contents. Access to these tanks is limited to small-diameter risers that allow for sample collection at only one discrete point below this opening. To collect a more representative sample without exposing workers to tank interiors, a remote-controlled retrieval method must be used. Many of the storage tanks have access penetrations that are 18 in. in diameter and, therefore, are not suitable for deployment of large vehicle systems like the Houdini (DOE/EM-0363). Often, the tanks offer minimal headspace and are so cluttered with pipes and other vertical obstructions that deployment of long-reach manipulators becomes an impractical option. A smaller vehicle system is needed that can deploy waste retrieval, sampling, and inspection tools into these tanks. The Oak Ridge National Laboratory (ORNL), along with ROV Technologies, Inc., and The Providence Group, Inc., (Providence) has developed the Scarab III remotely operated vehicle system to meet this need. The system also includes a containment and deployment structure and a jet pump-based, waste-dislodging and conveyance system to use in these limited-access tanks. The Scarab III robot addresses the need for a vehicle-based, rugged, remote-controlled system for collection of representative samples of tank contents. This document contains information on the above-mentioned technology, including description, applicability, cost, and performance data.

  5. Innovation of High-risk Infants Follow-up Surveillance System in Iran

    PubMed Central

    Jodeiry, Behzad; Heidarzadeh, Mohammad; Mirnia, Kayvan; Akrami, Forouzan; Heidarabadi, Seifoallah; Ebadi, Ali

    2015-01-01

    Background: Early childhood development is one of the most social determinants of health that must be notified in order to reducing social gap and inequity. In spite of increasingly developing intensive neonatal care wards and decreasing neonatal mortality rate, there is no follow-up surveillance system to identify high-risk infants (HRI) and their health problems for timely intervention after discharge. This study was carried out to design and pilot high-risk infant follow-ups (HRIFs) surveillance system, in Alzahra Hospital, a tertiary level center of Tabriz University of Medical Sciences (TUOMS), in 2012–2013. Methods: In this qualitative research after studying international documents, consensus about criteria of HRIs accomplished by focus group discussion. Then, Delphi agreement technique was used to finalizing assessment timetable. In the second phase, we piloted the designed surveillance system in Alzahra Hospital, a tertiary level center of TUOMS. Pilot study was implemented by follow-up team organized in designed model at the first phase of the study. Then, the findings of the pilot study were being assessed by an expert panel. If the members agreed on made decisions, they were being placed on the agenda of the national committee of development care of newborns for final approval. Results: High-risk infants follow-up surveillance system was designed in following steps: Defining of evidence-based criteria of HRIs, organizing the follow-up team, regulating the organs and neurodevelopment assessment timetable, publishing a health certificate notebook for HRIs, and designing Access database software for data collection, report and evaluation. Conclusions: We designed and piloted HRIFs surveillance system, so this system was institutionalized in Alzahra Hospital, finally. It can be prepared to apply in the whole country, after detecting the quantitative outcomes and developing the program in East Azarbijan. PMID:25969705

  6. Green-blue water system innovations for upgrading of smallholder farming systems--a policy framework for development.

    PubMed

    Hatibu, N; Rockström, J

    2005-01-01

    Rainfed agriculture and other depletion of water by green flows have as yet an untapped potential for improving livelihoods in semi-arid areas through income and food security. A vivid evidence of this is seen in the fact that, although working full time on food production, majority of smallholder farmers are frequently affected by shortage of food or famines. At the same time enough examples exist to show that productivity of labor, water and land under rainfed farming can be doubled or even trebled through proper land management and improved agronomic inputs supported by modest investments to reduce impacts of dry spells. However, these shining examples remain small 'islands of success' across the entire semi-arid areas. Farmers have not adopted these systems due to poor ratio of benefit to costs brought about by inadequate development or complete lack of food trade among the rural areas. This paper argues that there is a need for policy, strategic and programmatic frameworks which facilitate integrated management of land, water and markets. For this kind of strategy to work, a local market for food should be ensured to absorb at competitive prices the surplus produced by farmers in years of good rains. This will promote wealth creation and asset building among the poor in semi-arid areas. A food-exchange "futures" mechanism based on the principle of virtual water trade is proposed as a basis for achieving this objective.

  7. Innovative light collimator with afocal lens and total internal reflection lens for daylighting system.

    PubMed

    Chen, Bo-Jian; Chen, Yin-Ti; Ullah, Irfan; Chou, Chun-Han; Chan, Kai-Cyuan; Lai, Yi-Lung; Lin, Chia-Ming; Chang, Cheng-Ming; Whang, Allen Jong-Woei

    2015-10-01

    This research presents a novel design of the collimator, which uses total internal reflection (TIR), convex, and concave lenses for the natural light illumination system (NLIS). The concept of the NLIS is to illuminate building interiors with natural light, which saves energy consumption. The TIR lens is used to collimate the light, and convex and concave lenses are used to converge the light to the required area. The results have shown that the efficiency in terms of achieving collimated light using the proposed collimator at the output of the light collector is better than that of a previous system without a collimator. PMID:26479648

  8. Waste Crate and Container Imaging Using the Vehicle and Cargo Inspection System. Innovative Technology Summary Report

    SciTech Connect

    2000-07-01

    The Vehicle and Cargo Inspection System (VACIS) is a highly penetrating gamma ray imaging system that provides a means to non-invasively image crate contents prior to crate disassembly. The VACIS unit uses a 1.6 Curie collimated source (Cesium-137) aimed at a linear detector to create an image as the unit passes by the crate. In the demonstrated mobile unit, the source and detector were mounted on a boom truck. As the crate passed between the source and detector, a near real-time composite image of the contents was constructed from the linear image of the VACIS unit's on board computer and recorded on disk.

  9. Going Boldly Into the Future: A VET Journey Into the National Innovation System.

    ERIC Educational Resources Information Center

    Ferrier, Fran; Trood, Clifford; Whittingham, Karen

    Emerging and potential Australian industries were surveyed to identify the skills needed by their current and future workers and to determine how Australia's vocational and training (VET) system can best respond to those skill needs. The study investigated industries emerging from the work of Australia's Co-operative Research Centres program. The…

  10. The Systems Approach: An Innovative Model for Improving the Delivery of Inservice Training.

    ERIC Educational Resources Information Center

    Goodman, Gay; And Others

    1989-01-01

    This paper describes an effective systems approach for conducting physical therapy inservice training. The approach requires that the problem area be selected by staff consensus, and consists of eight elements such as "prioritizing needs" and "constructing performance measures." The approach is applied to planning and administering therapeutic…

  11. Student Perceptions and Effectiveness of an Innovative Learning Tool: Anatomy Glove Learning System

    ERIC Educational Resources Information Center

    Lisk, Kristina; McKee, Pat; Baskwill, Amanda; Agur, Anne M. R.

    2015-01-01

    A trend in anatomical education is the development of alternative pedagogical approaches to replace or complement experiences in a cadaver laboratory; however, empirical evidence on their effectiveness is often not reported. This study aimed to evaluate the effectiveness of Anatomy Glove Learning System (AGLS), which enables students to learn the…

  12. The Effects of Technology Innovativeness and System Exposure on Student Acceptance of E-Textbooks

    ERIC Educational Resources Information Center

    Ngafeeson, Madison N.; Sun, Jun

    2015-01-01

    The efforts of educators in the last three decades have, among other things, focused on the use of information technology (IT) in education. It has become commonplace to view information systems both as an effective carrier of course content as well as a cost-effective tool to improve student learning outcomes. One of such technologies is the…

  13. The state of the art on innovative monitoring system in Korea

    NASA Astrophysics Data System (ADS)

    Park, Ki-Tae; Kim, Taeheon; Kim, Hee Ju; Kim, Byungchul

    2016-04-01

    Damage to infrastructure is a real concern at present, caused primarily by worldwide climate anomalies, global warming, and natural disasters. Korea has begun research to develop a high precision patch/implant system using new IT techniques since 2011 and technologies which must be developed for this research are those which measure and evaluate the soundness and safety of structures based on the measurements of an attached sensor. During the research period since 2011, optical fiber sensor patches and wireless sensor capsule implants along with various sensor technologies, stress sensing and structural condition evaluation algorithm have been developed effectively for network hardware technologies as prototype version. Similarly high precision image processing for automatic crack extraction have been developed along with radiation sensor application technologies, combined management/control technologies for developed systems, and practical technologies for building and large scale structure. Through the results, it is expected that we acquire higher sensor system performance with a measurement scope (for precision, etc.) goal at least 200% better than conventional sensor systems.

  14. Legacy of the Rural Systemic Initiatives: Innovation, Leadership, Teacher Development, and Lessons Learned

    ERIC Educational Resources Information Center

    Harmon, Hobart L.; Smith, Keith C.

    2012-01-01

    This monograph offers an in-depth look at the National Science Foundation's (NSF) Rural Systemic Initiative (RSI) efforts, an investment of more than $140 million to reform mathematics and science programs in rural K-12 public education and tribal education. The authors seek to promote a foundation of contextual understanding for improving public…

  15. Innovative LIDAR 3D Dynamic Measurement System to estimate fruit-tree leaf area.

    PubMed

    Sanz-Cortiella, Ricardo; Llorens-Calveras, Jordi; Escolà, Alexandre; Arnó-Satorra, Jaume; Ribes-Dasi, Manel; Masip-Vilalta, Joan; Camp, Ferran; Gràcia-Aguilá, Felip; Solanelles-Batlle, Francesc; Planas-DeMartí, Santiago; Pallejà-Cabré, Tomàs; Palacin-Roca, Jordi; Gregorio-Lopez, Eduard; Del-Moral-Martínez, Ignacio; Rosell-Polo, Joan R

    2011-01-01

    In this work, a LIDAR-based 3D Dynamic Measurement System is presented and evaluated for the geometric characterization of tree crops. Using this measurement system, trees were scanned from two opposing sides to obtain two three-dimensional point clouds. After registration of the point clouds, a simple and easily obtainable parameter is the number of impacts received by the scanned vegetation. The work in this study is based on the hypothesis of the existence of a linear relationship between the number of impacts of the LIDAR sensor laser beam on the vegetation and the tree leaf area. Tests performed under laboratory conditions using an ornamental tree and, subsequently, in a pear tree orchard demonstrate the correct operation of the measurement system presented in this paper. The results from both the laboratory and field tests confirm the initial hypothesis and the 3D Dynamic Measurement System is validated in field operation. This opens the door to new lines of research centred on the geometric characterization of tree crops in the field of agriculture and, more specifically, in precision fruit growing.

  16. Development of an Innovative Interactive Virtual Classroom System for K-12 Education Using Google App Engine

    ERIC Educational Resources Information Center

    Mumba, Frackson; Zhu, Mengxia

    2013-01-01

    This paper presents a Simulation-based interactive Virtual ClassRoom web system (SVCR: www.vclasie.com) powered by the state-of-the-art cloud computing technology from Google SVCR integrates popular free open-source math, science and engineering simulations and provides functions such as secure user access control and management of courses,…

  17. Innovative LIDAR 3D Dynamic Measurement System to estimate fruit-tree leaf area.

    PubMed

    Sanz-Cortiella, Ricardo; Llorens-Calveras, Jordi; Escolà, Alexandre; Arnó-Satorra, Jaume; Ribes-Dasi, Manel; Masip-Vilalta, Joan; Camp, Ferran; Gràcia-Aguilá, Felip; Solanelles-Batlle, Francesc; Planas-DeMartí, Santiago; Pallejà-Cabré, Tomàs; Palacin-Roca, Jordi; Gregorio-Lopez, Eduard; Del-Moral-Martínez, Ignacio; Rosell-Polo, Joan R

    2011-01-01

    In this work, a LIDAR-based 3D Dynamic Measurement System is presented and evaluated for the geometric characterization of tree crops. Using this measurement system, trees were scanned from two opposing sides to obtain two three-dimensional point clouds. After registration of the point clouds, a simple and easily obtainable parameter is the number of impacts received by the scanned vegetation. The work in this study is based on the hypothesis of the existence of a linear relationship between the number of impacts of the LIDAR sensor laser beam on the vegetation and the tree leaf area. Tests performed under laboratory conditions using an ornamental tree and, subsequently, in a pear tree orchard demonstrate the correct operation of the measurement system presented in this paper. The results from both the laboratory and field tests confirm the initial hypothesis and the 3D Dynamic Measurement System is validated in field operation. This opens the door to new lines of research centred on the geometric characterization of tree crops in the field of agriculture and, more specifically, in precision fruit growing. PMID:22163926

  18. Innovative formulation of nystatin particulate systems in toothpaste for candidiasis treatment.

    PubMed

    Pinto Reis, Catarina; Vasques Roque, Luís; Baptista, Marina; Rijo, Patrícia

    2016-01-01

    Oral candidiasis is a mycosis on the mucous membranes of the mouth but not limited to the mouth. Nystatin is one of the most frequently employed antifungal agents to treat infections and may be safely given orally as well as applied topically but its absorption through mucocutaneous membranes such as the gut and the skin is minimal. The purpose of this study is to enhance the effectiveness of nystatin using particulate system such as beads, micro- and nanoparticles of alginate incorporated into toothpaste. Those particulate systems of nystatin were prepared by extrusion/external gelation for beads and emulsification/internal gelation for micro- and nanoparticles and characterized. Small, anionic charged and monodispersed particles were successfully produced. The type of particulate system influenced all previous parameters, being microparticles the most suitable particulate system of nystatin showing the slowest release, the highest inhibitory effect of Candida albicans over a period of one year. Those results allowed the conclusion that alginate exhibits properties that enable the in vitro functionality of encapsulated nystatin and thus may provide the basis for new successful approaches for the treatment of oral antifungal infections such as oral candidiasis.

  19. Usage Patterns and Perceptions of the Achievement Reporting and Innovation System (ARIS). Report

    ERIC Educational Resources Information Center

    Gold, Thomas; Lent, Jessica; Cole, Rachel; Kemple, James; Nathanson, Lori; Brand, Janet

    2012-01-01

    The federal government, states, school districts, and private foundations are investing hundreds of millions of dollars in educational data management systems. The hope for these investments is that providing better information to teachers and administrators, particularly student performance data, will support school-wide planning, inform…

  20. Usage Patterns and Perceptions of the Achievement Reporting and Innovation System (ARIS). Executive Summary

    ERIC Educational Resources Information Center

    Gold, Thomas; Lent, Jessica; Cole, Rachel; Kemple, James; Nathanson, Lori; Brand, Janet

    2012-01-01

    The federal government, states, school districts, and private foundations are investing hundreds of millions of dollars in educational data management systems. The hope for these investments is that providing better information to teachers and administrators, particularly student performance data, will support school-wide planning, inform…

  1. Usage Patterns and Perceptions of the Achievement Reporting and Innovation System (ARIS). Technical Appendices

    ERIC Educational Resources Information Center

    Gold, Thomas; Lent, Jessica; Cole, Rachel; Kemple, James; Nathanson, Lori; Brand, Janet

    2012-01-01

    The federal government, states, school districts, and private foundations are investing hundreds of millions of dollars in educational data management systems. The hope for these investments is that providing better information to teachers and administrators, particularly student performance data, will support school-wide planning, inform…

  2. The Innovative Activity of Schools in a Regional System of Education

    ERIC Educational Resources Information Center

    Larina, V. P.

    2006-01-01

    Education today is characterized by two opposite tendencies: (1) A centripetal tendency, which conditions the link between the region and the center, without which it is not possible to find local solutions to a number of important problems related to resource support for the regional system of education (legal, normative, material and technical,…

  3. Federal Government Information Systems Security Management and Governance Are Pacing Factors for Innovation

    ERIC Educational Resources Information Center

    Edwards, Gregory

    2011-01-01

    Security incidents resulting from human error or subversive actions have caused major financial losses, reduced business productivity or efficiency, and threatened national security. Some research suggests that information system security frameworks lack emphasis on human involvement as a significant cause for security problems in a rapidly…

  4. GIS\\KEY™ ENVIRONMENTAL DATA MANAGEMENT SYSTEM - INNOVATIVE TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    GIS/Key™ is a comprehensive environmental database management system that integrates site data and graphics, enabling the user to create geologic cross-sections; boring logs; potentiometric, isopleth, and structure maps; summary tables; and hydrographs. GIS/Key™ is menu-driven an...

  5. Diffusion of Innovation: A Case Study of Course Management System Adoption

    ERIC Educational Resources Information Center

    Powell, Phillip, Ed.D.

    2008-01-01

    The purpose of this study was to examine the processes of evaluation, selection, adoption and diffusion of a course management system (CMS). This study incorporated a cross-case analysis using a multiple case study approach, which included two institutions, each having six participants. The participants were placed into three categories: faculty,…

  6. INNOVATIONS IN THE DEVELOPMENT OF CURRICULA FOR DIFFERENTIALLY-PACED SYSTEMS.

    ERIC Educational Resources Information Center

    OLIAN, MAXINE

    A MODEL FOR CURRICULUM DEVELOPMENT WITH DIFFERENTIALLY PACED SYSTEMS OF LEARNING WAS DESIGNED, IMPLEMENTED, AND EVALUATED. THE MODEL WAS BASED ON THE CURRENT STATE-OF-THE-ART AND PROVIDED DETAILED MECHANIZATION BY WHICH STUDENTS IN MASS TRAINING EFFORTS COULD PROCEED AT THEIR OPTIMAL, INDIVIDUAL RATES OF LEARNING TOWARD THE ATTAINMENT OF COURSE…

  7. Using the Diffusion of Innovation Theory to Explain the Degree of English Teachers' Adoption of Interactive Whiteboards in the Modern Systems School in Jordan: A Case Study

    ERIC Educational Resources Information Center

    Jwaifell, Mustafa; Gasaymeh, Al-Mothana

    2013-01-01

    This study aimed to explain the use of interactive whiteboards (IWBs) by English female teachers in Modern Systems School in Jordan. Viewed from the lens of Rogers' Diffusion of Innovation Theory, the study examined and reported teachers' use of IWB and its features that have impact on their decisions to adopt it in Modern Systems School . The…

  8. Innovative High-Accuracy Lidar Bathymetric Technique for the Frequent Measurement of River Systems

    NASA Astrophysics Data System (ADS)

    Gisler, A.; Crowley, G.; Thayer, J. P.; Thompson, G. S.; Barton-Grimley, R. A.

    2015-12-01

    Lidar (light detection and ranging) provides absolute depth and topographic mapping capability compared to other remote sensing methods, which is useful for mapping rapidly changing environments such as riverine systems. Effectiveness of current lidar bathymetric systems is limited by the difficulty in unambiguously identifying backscattered lidar signals from the water surface versus the bottom, limiting their depth resolution to 0.3-0.5 m. Additionally these are large, bulky systems that are constrained to expensive aircraft-mounted platforms and use waveform-processing techniques requiring substantial computation time. These restrictions are prohibitive for many potential users. A novel lidar device has been developed that allows for non-contact measurements of water depth down to 1 cm with an accuracy and precision of < 1 cm by exploiting the polarization properties of the light-surface interaction. This system can transition seamlessly from ranging over land to shallow to deep water allowing for shoreline charting, measuring water volume, mapping bottom topology, and identifying submerged objects. The scalability of the technique opens up the ability for handheld or UAS-mounted lidar bathymetric systems, which provides for potential applications currently unavailable to the community. The high laser pulse repetition rate allows for very fine horizontal resolution while the photon-counting technique permits real-time depth measurement and object detection. The enhanced measurement capability, portability, scalability, and relatively low-cost creates the opportunity to perform frequent high-accuracy monitoring and measuring of aquatic environments which is crucial for understanding how rivers evolve over many timescales. Results from recent campaigns measuring water depth in flowing creeks and murky ponds will be presented which demonstrate that the method is not limited by rough water surfaces and can map underwater topology through moderately turbid water.

  9. The Implementation of Inmate Mentor Programs in the Correctional Treatment System as an Innovative Approach

    ERIC Educational Resources Information Center

    Cook, Jana; McClure, Scott; Koutsenok, Igor; Lord, Scot

    2008-01-01

    In October 2006, the California Men's Colony (CMC) in San Luis Obispo, faced with staff recruitment and retention difficulties, took an innovative step to utilize long-term sentenced inmates as peer mentors and primary counselors to lead their prison-based therapeutic community (TC) program. The program was designed, developed, and implemented…

  10. ICT-Integrated Education and National Innovation Systems in the Gulf Cooperation Council (GCC) Countries

    ERIC Educational Resources Information Center

    Wiseman, Alexander W.; Anderson, Emily

    2012-01-01

    The widespread use and availability of information and communication technologies (ICT) has greatly impacted how nations conceptualize innovation and the ways formal mass education can be used to advance socio-political and economic agendas. The Gulf Cooperation Council (GCC) countries have increasingly focused on the roles of science and…

  11. The Adoption of Systems Innovations in Educational Organizations: A Case Study of Operation Guidance.

    ERIC Educational Resources Information Center

    Kester, Ralph J.; Howard, John, Jr.

    To identify factors which affect the acceptance of innovation in school organizations, a career development product entitled Operation Guidance (OG) was the object of a case study. Five basic organizational characteristics were used to roughly quantify attributes of the organization of the six schools studied. The characteristics were:…

  12. CKD screening and management in the Veterans Health Administration: the impact of system organization and an innovative electronic record.

    PubMed

    Patel, Thakor G; Pogach, Leonard M; Barth, Robert H

    2009-03-01

    At the beginning of this decade, Healthy People 2010 issued a series of objectives to "reduce the incidence, morbidity, mortality and health care costs of chronic kidney disease." A necessary feature of any program to reduce the burden of kidney disease in the US population must include mechanisms to screen populations at risk and institute early the aspects of management, such as control of blood pressure, management of diabetes, and, in patients with advanced chronic kidney disease (CKD), preparation for dialysis therapy and proper vascular access management, that can retard CKD progression and improve long-term outcome. The Department of Veterans Affairs and the Veterans Health Administration is a broad-based national health care system that is almost uniquely situated to address these issues and has developed a number of effective approaches using evidence-based clinical practice guidelines, performance measures, innovative use of a robust electronic medical record system, and system oversight during the past decade. In this report, we describe the application of this systems approach to the prevention of CKD in veterans through the treatment of risk factors, identification of CKD in veterans, and oversight of predialysis and dialysis care. The lessons learned and applicability to the private sector are discussed.

  13. SPY: an innovative intra-operative imaging system to evaluate graft patency during off-pump coronary artery bypass grafting.

    PubMed

    Takahashi, Masao; Ishikawa, Toshihiro; Higashidani, Koichi; Katoh, Hiroki

    2004-09-01

    Off-pump coronary artery bypass grafting (CABG) has been rapidly increased, because of its less invasiveness with low complications. However, graft patency rate highly depends on the operators' capability due to technical difficulties. The SPY system, based on the fluorescence of indocyanine green, is an innovative device that permits validation of graft patency intra-operatively. Real time images of grafts are obtained with no need for catheterization, X-rays or iodine contrast medium. High-quality images could be obtained in all 290 grafts of 72 off-pump CABG cases (mean 4.0 grafts per patient). Four anastomoses (1.4%), including two proximal and two distal, were revised because of defects detected by SPY images. In one case, the SPY system revealed no blood flow in a radial sequential graft, although transit-time flow meter measurements showed a diastolic dominant pattern. SPY images provide critical information to surgeons to detect non-patent grafts, allowing them to be revised while the patient is still on the operating table. Using the SPY system, technical failures could be completely resolved during surgery. The use of the SPY system for intra-operative graft validation during off-pump CABG may become the gold standard for surgical management in the near future.

  14. Plants + microbes: Innovative food crop systems that also clean air and water

    NASA Astrophysics Data System (ADS)

    Nelson, Mark; Wolverton, B. C.

    The limitations that will govern bioregenerative life support applications in space, especially volume and weight, make multi-purpose systems advantageous. This paper outlines two systems which utilize plants and associated microbial communities of root or growth medium to both produce food crops and clean air and water. Underlying these approaches are the large numbers and metabolic diversity of microbes associated with roots and found in either soil or other suitable growth media. It is known that most biogeochemical cycles have a microbial link, and the ability of microbes to metabolize virtually all trace gases, whether of technogenic or biogenic origin, have long been established. Wetland plants and soil/media also been extensively researched for their ability to purify wastewaters of all kinds of potential water pollutants, from nutrients like N and P, to heavy metals and a range of complex industrial pollutants. There is a growing body of research on the ability of higher plants to purify air and water. Associated benefits of these approaches is that by utilizing natural ecological processes, the cleansing of air and water can be done with little or no energy inputs. Soil and root microorganisms respond to changing pollutant types by an increase of the types of organisms with the capacity to use these compounds. Thus living systems have an extraordinary adaptive capacity as long as the starting populations are sufficiently diverse. It is known that tightly sealed environments, from office buildings to spacecraft, can have hundreds or even thousands of potential air pollutants, depending on the materials and machines enclosed. Human waste products carry a plethora of microbes can are readily used in the process of converting its organic load to forms that can be utilized by green plants. Having endogenous means of responding to changing air and water quality conditions represents safety factors which operate without the need for human direction. We will

  15. Green genes: bioinformatics and systems-biology innovations drive algal biotechnology.

    PubMed

    Reijnders, Maarten J M F; van Heck, Ruben G A; Lam, Carolyn M C; Scaife, Mark A; dos Santos, Vitor A P Martins; Smith, Alison G; Schaap, Peter J

    2014-12-01

    Many species of microalgae produce hydrocarbons, polysaccharides, and other valuable products in significant amounts. However, large-scale production of algal products is not yet competitive against non-renewable alternatives from fossil fuel. Metabolic engineering approaches will help to improve productivity, but the exact metabolic pathways and the identities of the majority of the genes involved remain unknown. Recent advances in bioinformatics and systems-biology modeling coupled with increasing numbers of algal genome-sequencing projects are providing the means to address this. A multidisciplinary integration of methods will provide synergy for a systems-level understanding of microalgae, and thereby accelerate the improvement of industrially valuable strains. In this review we highlight recent advances and challenges to microalgal research and discuss future potential. PMID:25457388

  16. Green genes: bioinformatics and systems-biology innovations drive algal biotechnology.

    PubMed

    Reijnders, Maarten J M F; van Heck, Ruben G A; Lam, Carolyn M C; Scaife, Mark A; dos Santos, Vitor A P Martins; Smith, Alison G; Schaap, Peter J

    2014-12-01

    Many species of microalgae produce hydrocarbons, polysaccharides, and other valuable products in significant amounts. However, large-scale production of algal products is not yet competitive against non-renewable alternatives from fossil fuel. Metabolic engineering approaches will help to improve productivity, but the exact metabolic pathways and the identities of the majority of the genes involved remain unknown. Recent advances in bioinformatics and systems-biology modeling coupled with increasing numbers of algal genome-sequencing projects are providing the means to address this. A multidisciplinary integration of methods will provide synergy for a systems-level understanding of microalgae, and thereby accelerate the improvement of industrially valuable strains. In this review we highlight recent advances and challenges to microalgal research and discuss future potential.

  17. Engineering America's Future in Space: Systems Engineering Innovations for Sustainable Exploration

    NASA Technical Reports Server (NTRS)

    Dumbacher, Daniel L.; Jones, Carl P.

    2008-01-01

    The National Aeronautics and Space Administration (NASA) delivers space transportation solutions for America's complex missions, ranging from scientific payloads that expand knowledge, such as the Hubble Space Telescope, to astronauts and lunar rovers destined for voyages to the Moon. Currently, the venerable Space Shuttle, which has been in service since 1981, provides U.S. capability for both crew and cargo to low-Earth orbit to construct the International Space Station, before the Shuttle is retired in 2010, as outlined in the 2006 NASA Strategic Plan. I In the next decade, NASA will replace this system with a duo of launch vehicles: the Ares I Crew Launch Vehicle/Orion Crew Exploration Vehicle and the Ares V Cargo Launch Vehicle/Altair Lunar Lander. The goals for this new system include increased safety and reliability, coupled with lower operations costs that promote sustainable space exploration over a multi-decade schedule. This paper will provide details of the in-house systems engineering and vehicle integration work now being performed for the Ares I and planned for the Ares V. It will give an overview of the Ares I system-level test activities, such as the ground vibration testing that will be conducted in the Marshall Center's Dynamic Test Stand to verify the integrated vehicle stack's structural integrity against predictions made by modern modeling and simulation analysis. It also will give information about the work in progress for the Ares I-X developmental test flight planned in 2009 to provide key data before the Ares I Critical Design Review. Activities such as these will help prove and refine mission concepts of operation, while supporting the spectrum of design and development tasks being performed by Marshall's Engineering Directorate, ranging from launch vehicles and lunar rovers to scientific spacecraft and associated experiments. Ultimately, the work performed will lead to the fielding of a robust space transportation solution that will

  18. Ahmad's NPRT System: A Practical Innovation for Documenting Male Pattern Baldness

    PubMed Central

    Ahmad, Muhammad

    2016-01-01

    Various classifications for male pattern baldness are mentioned in the literature. The ‘Norwood's classification is the most commonly used but it has certain limitations. The new system has included ‘three’ extra features which were not mentioned in any other classification. It provides an opportunity to document the full and correct picture while documenting male pattern baldness. It also aids in assessing the treatment for various degrees of baldness. PMID:27761091

  19. An innovative system for heating and cooling a gymnasium using integrated photovoltaic-thermal solar collectors

    SciTech Connect

    Fanchiotti, A.; Herkel, S.; Laukamp, H.; Priolo, C.

    1996-11-01

    The paper describes a new solar energy based system to heat and cool a gymnasium and to generate electricity in the city of Palermo, Italy. The gymnasium will be built in 1996 as part of the structures that will host the Universiadi Games in 1997. Main objectives of the project are: (a) to grant better environmental conditions in the area occupied by the public, with limited use of fossil energy; (b) to reduce the temperature of the photovoltaic elements, thus increasing their efficiency. The system consists of an array of 203 m{sup 2} integrated photovoltaic-thermal solar air collectors. In the winter mode of operation, the heated air is passed through the concrete benches where the public is seated. In the summer mode of operation outside air is evaporatively cooled, passed through the benches, then exhausted to the outside after passing through the collectors. The paper presents some of the results obtained by simulating the system at the design stage for winter conditions.

  20. Soil consumption: An innovative system for better planning and managing soil in urban planning context

    NASA Astrophysics Data System (ADS)

    Basile, Angelo; Bonfante, Antonello; Langella, Giuliano; Minieri, Luciana; De Michele, Carlo; D'Antonio, Amedeo; Manna, Piero; Terribile, Fabio

    2015-04-01

    Soil is a key natural resource and most crucial ecosystem services and the most important environmental benefits to humankind and the environment depend by its properties. However, soil is a delicate resource. Urbanization is the most impactful use of soils because it can cancel all its ecosystem functions and ends forever its life cycle since soil is removed completely and/or sealed with a cement/bitumen layer. The absence of an adequate soil culture led common urban planning to do not consider the reality of soil as living multifunctional system. In such framework, this work - performed under the project LIFE + SOILCONSWEB - aims to illustrate a different approach for soil management in spatial planning using a Spatial Decision Support System operating through the web (w-SDSS) to evaluate soil consumption. The system - already operating in an area of Southern Italy (Telese valley, 20,000 ha) - allows - in real time - to provide answers such as (i) the use of land (type and size) on different dates, (ii) mapping and statistics on the sprawl at the municipality scale, (iii) detailed mapping of land fragmentation (and statistical fragmentation) on different dates, (iv) quantification of loss of ecosystem services after potential new urbanization.

  1. MERIS (Medical Error Reporting Information System) as an innovative patient safety intervention: a health policy perspective.

    PubMed

    Riga, Marina; Vozikis, Athanassios; Pollalis, Yannis; Souliotis, Kyriakos

    2015-04-01

    The economic crisis in Greece poses the necessity to resolve problems concerning both the spiralling cost and the quality assurance in the health system. The detection and the analysis of patient adverse events and medical errors are considered crucial elements of this course. The implementation of MERIS embodies a mandatory module, which adopts the trigger tool methodology for measuring adverse events and medical errors an intensive care unit [ICU] environment, and a voluntary one with web-based public reporting methodology. A pilot implementation of MERIS running in a public hospital identified 35 adverse events, with approx. 12 additional hospital days and an extra healthcare cost of €12,000 per adverse event or of about €312,000 per annum for ICU costs only. At the same time, the voluntary module unveiled 510 reports on adverse events submitted by citizens or patients. MERIS has been evaluated as a comprehensive and effective system; it succeeded in detecting the main factors that cause adverse events and discloses severe omissions of the Greek health system. MERIS may be incorporated and run efficiently nationally, adapted to the needs and peculiarities of each hospital or clinic.

  2. Novel delivery systems for anti-allergic agents: allergic disease and innovative treatments.

    PubMed

    Lopes, Carla M; Coelho, Pedro B; Oliveira, Rita

    2015-01-01

    Anti-allergic agents are used to treat a great variety of diseases which usually involve an inflammation reaction. These compounds act by inhibiting the release and the effects of inflammatory mediators (e.g. histamine) in the target tissue. The purpose of anti-allergy therapy is to deliver the drug to its local of action in a therapeutic concentration, minimizing the undesired side effects. In order to solve some of the anti-allergic agents' physicochemical drawbacks and the limitations associated to conventional pharmaceutical formulations (e.g. poor solubility and absorption, skin permeation, stability), novel drug delivery systems, such as cyclodextrins, liposomes, micelles, microemulsions, nano and microparticles, have been developed. Depending on the allergic condition, several administration routes are used to deliver anti-allergic agents, each with its own disadvantages to overcome. In the literature, there are a vast number of papers concerning novel delivery systems for anti-allergic agents, making it difficult to evaluate the information and the promising outcomes. The aim of the present review article is to compile the recent (i.e. in the new millennium) improvements of novel drug delivery technology focusing on the achievement of anti-allergic therapeutic delivery. The potential intrinsic benefits of these systems will reflect an increased therapeutic adherence and better patients' life quality. A critical prospect of future clinical trial directions will also be discussed. PMID:25895551

  3. Innovative systems for mixed waste retrieval and/or treatment in confined spaces

    SciTech Connect

    Fekete, L.J.; Ghusn, A.E.

    1993-03-01

    Fernald established operations in 1951 and produced uranium and other metals for use at other DOE facilities. A part of the sitewide remediation effort is the removal, treatment, and disposal of the K-65 wastes from Silos 1 and 2. These silos contain radium-bearing residues from the processing of pitchblende ore. An Engineering Evaluation/Cost Analysis was prepared to evaluate the removal action alternatives using the preliminary characterization data and select a preferred alternative. The selected alternative consisted of covering the K-65 residues and the silo dome. The remediation of the K-65 wastes consists of the retrieval and treatment of the wastes prior to final disposal, which has not yet been determined. Treatment will be performed in a new facility to be built adjacent to the silos. The wastes must be retrieved from silos in an efficient and reliable way and delivered to the treatment facility. The first challenge of covering the wastes with bentonite has been successfully met. The second phase of retrieving the wastes from the silos is not due for a few years. However, conceptual design and configuration of the retrieval system have been developed as part of the Conceptual Design Report. The system is based on the utilization of hydraulic mining techniques, and is based on similar successful applications. This report describes the emplacement of the bentonite grant and the design for the slurry retrieval system.

  4. Popular discourse on expert systems: communication patterns in the acculturation of an A. I. innovation

    SciTech Connect

    Opt, S.K.

    1987-01-01

    This study offers an organicist, trialectical communication perspective for analyzing the assumed relationship between technology and society. Other persons who have examined this relationship primarily have construed it as one in which (1) technology drives social change or (2) society drives technological change. Unanswered, though, is: what drives the relationship. This becomes the focus of this study. The study argues that understanding communication patterns about a technology (1) shows the processes by which human beings constitute sense-making scenarios about a technology, (2) makes salient the scenarios' implications for human needs, relationships, and worldview, and (3) provides an alternative approach to thinking about intervention into and side effects arising from the symbolic constitution of the future. The technology considered as case study is expert systems, and, by extension, artificial intelligence. The study focuses on the communication system of AI researchers, business persons, critics, and writers and their roles in inventing pasts, presents, and futures for the technology. The study finds that participants in discourse constitute names for expert systems in relation to the overarching ideology - the American dream.

  5. Engineering, global health, and inclusive innovation: focus on partnership, system strengthening, and local impact for SDGs.

    PubMed

    Clifford, Katie L; Zaman, Muhammad H

    2016-01-01

    The recent drafting of the Sustainable Development Goals challenges the research community to rethink the traditional approach to global health and provides the opportunity for science, technology, engineering, and mathematical (STEM) disciplines, particularly engineering, to demonstrate their benefit to the field. Higher education offers a platform for engineering to intersect with global health research through interdisciplinary partnerships among international universities that provide excellence in education, attract nontraditional STEM students, and foster a sense of innovation. However, a traditional lack of engineering-global health collaborations, as well as limited faculty and inadequate STEM research funding in low-income countries, has stifled progress. Still, the impact of higher education on development efforts holds great potential. This value will be realized in low-income countries through strengthening local capacity, supporting innovation through educational initiatives, and encouraging the inclusion of women and minorities in STEM programs. Current international university-level partnerships are working towards integrating engineering into global health research and strengthening STEM innovation among universities in low-income countries, but more can be done. Global health research informs sustainable development, and through integrating engineering into research efforts through university partnerships, we can accelerate progress and work towards a healthier future for all. PMID:26790462

  6. Engineering, global health, and inclusive innovation: focus on partnership, system strengthening, and local impact for SDGs.

    PubMed

    Clifford, Katie L; Zaman, Muhammad H

    2016-01-01

    The recent drafting of the Sustainable Development Goals challenges the research community to rethink the traditional approach to global health and provides the opportunity for science, technology, engineering, and mathematical (STEM) disciplines, particularly engineering, to demonstrate their benefit to the field. Higher education offers a platform for engineering to intersect with global health research through interdisciplinary partnerships among international universities that provide excellence in education, attract nontraditional STEM students, and foster a sense of innovation. However, a traditional lack of engineering-global health collaborations, as well as limited faculty and inadequate STEM research funding in low-income countries, has stifled progress. Still, the impact of higher education on development efforts holds great potential. This value will be realized in low-income countries through strengthening local capacity, supporting innovation through educational initiatives, and encouraging the inclusion of women and minorities in STEM programs. Current international university-level partnerships are working towards integrating engineering into global health research and strengthening STEM innovation among universities in low-income countries, but more can be done. Global health research informs sustainable development, and through integrating engineering into research efforts through university partnerships, we can accelerate progress and work towards a healthier future for all.

  7. Engineering, global health, and inclusive innovation: focus on partnership, system strengthening, and local impact for SDGs

    PubMed Central

    Clifford, Katie L.; Zaman, Muhammad H.

    2016-01-01

    The recent drafting of the Sustainable Development Goals challenges the research community to rethink the traditional approach to global health and provides the opportunity for science, technology, engineering, and mathematical (STEM) disciplines, particularly engineering, to demonstrate their benefit to the field. Higher education offers a platform for engineering to intersect with global health research through interdisciplinary partnerships among international universities that provide excellence in education, attract nontraditional STEM students, and foster a sense of innovation. However, a traditional lack of engineering–global health collaborations, as well as limited faculty and inadequate STEM research funding in low-income countries, has stifled progress. Still, the impact of higher education on development efforts holds great potential. This value will be realized in low-income countries through strengthening local capacity, supporting innovation through educational initiatives, and encouraging the inclusion of women and minorities in STEM programs. Current international university-level partnerships are working towards integrating engineering into global health research and strengthening STEM innovation among universities in low-income countries, but more can be done. Global health research informs sustainable development, and through integrating engineering into research efforts through university partnerships, we can accelerate progress and work towards a healthier future for all. PMID:26790462

  8. The socio-economic landscape of biotechnology in Spain. A comparative study using the innovation system concept.

    PubMed

    Díaz, V; Muñoz, E; de los Monteros, J Espinosa; Senker, Jacqueline

    2002-09-11

    Biotechnology is becoming a crucial factor for the innovation strategies of the industrialised countries. Thus, the analysis of the sector is gaining relevance for the identification of the technological strength and potential of a country (or region) in a context of globalisation. A specific national case study may serve for more general comparative analyses. We have selected the case of Spain as illustrative of the complexity and differences existing in Europe. By using the analytical framework of the "national systems of innovation" concept, we have performed a multistep analysis of the biotechnology sector in Spain, focussing first on regions of Madrid and Cataluña which together account for more than 50% of the sector in Spain. The firms in both regions have followed a common strategy based on diversification and investment in R&D and innovation, so as to be able to compete in an international and competitive environment. There are, however, some interesting differences between the two subsectors; the one from Cataluña being more based on industrial traditions, and the one from Madrid characterised by the emergence of more specialised firms. The study has been extended to the remainder of Spanish firms for comparative purposes. The case of Spain is illustrative of the divergences existing in the biotechnology sector in Europe. A comparison is made with the structural and organisational characteristics of the biotechnology sector in several European countries. It shows that there is diversity in the pattern of commercialisation between countries and within regions of countries. Understanding these differences may assist the design of appropriate policies to promote the development of biotechnology in Europe.

  9. Twenty-first century vaccinomics innovation systems: capacity building in the global South and the role of Product Development Partnerships (PDPs).

    PubMed

    Huzair, Farah; Borda-Rodriguez, Alexander; Upton, Mary

    2011-09-01

    The availability of sequence information from publicly available complete genomes and data intensive sciences, together with next-generation sequencing technologies offer substantial promise for innovation in vaccinology and global public health in the beginning of the 21st century. This article presents an innovation analysis for the nascent field of vaccinomics by describing one of the major challenges in this endeavor: the need for capacities in "vaccinomics innovation systems" to support the developing countries involved in the creation and testing of new vaccines. In particular, we discuss the need for understanding how institutional frameworks can enhance capacities as intrinsic to a systems approach to health technology development. We focus our attention on the global South, meaning the technically less advanced and developing nations in Africa, Asia, and Latin America. This focus is timely and appropriate because the challenge for innovation in postgenomics medicine is markedly much greater in these regions where basic infrastructures are often underresourced and new or the anticipated institutional relationships can be fragile. Importantly, we examine the role of Product Development Partnerships (PDPs) as a 21st century organizational innovation that contributes to strengthening fragile institutions and capacity building. For vaccinomics innovation systems to stand the test of time in a context of global public health, local communities, knowledge, and cultures need to be collectively taken into account at all stages in programs for vaccinomics-guided vaccine development and delivery in the global South where the public health needs for rational vaccine development are urgent. PMID:21732822

  10. Twenty-first century vaccinomics innovation systems: capacity building in the global South and the role of Product Development Partnerships (PDPs).

    PubMed

    Huzair, Farah; Borda-Rodriguez, Alexander; Upton, Mary

    2011-09-01

    The availability of sequence information from publicly available complete genomes and data intensive sciences, together with next-generation sequencing technologies offer substantial promise for innovation in vaccinology and global public health in the beginning of the 21st century. This article presents an innovation analysis for the nascent field of vaccinomics by describing one of the major challenges in this endeavor: the need for capacities in "vaccinomics innovation systems" to support the developing countries involved in the creation and testing of new vaccines. In particular, we discuss the need for understanding how institutional frameworks can enhance capacities as intrinsic to a systems approach to health technology development. We focus our attention on the global South, meaning the technically less advanced and developing nations in Africa, Asia, and Latin America. This focus is timely and appropriate because the challenge for innovation in postgenomics medicine is markedly much greater in these regions where basic infrastructures are often underresourced and new or the anticipated institutional relationships can be fragile. Importantly, we examine the role of Product Development Partnerships (PDPs) as a 21st century organizational innovation that contributes to strengthening fragile institutions and capacity building. For vaccinomics innovation systems to stand the test of time in a context of global public health, local communities, knowledge, and cultures need to be collectively taken into account at all stages in programs for vaccinomics-guided vaccine development and delivery in the global South where the public health needs for rational vaccine development are urgent.

  11. A system-wide innovation in transition services: transforming the home care liaison role.

    PubMed

    Meadows, Carl A; Fraser, Julie; Camus, Susann; Henderson, Kathy

    2014-02-01

    This article describes how a provincial health authority in Canada improved patient care and staff satisfaction by transforming the role of home care (HC) liaison. The transformation focused on clearly defining the role, function and reporting structure, and identifying which healthcare providers could fill the liaison role. The transformation included adoption of transition best practices, leveraging an electronic referral system, creation of an interprofessional team, standardization of tools/orientation, and strong evaluation metrics, centralizing decision making, and developing a process for streaming referrals. The authors identify key success factors that made the transformation possible, as well as challenges and work that remains to sustain the change. PMID:24492265

  12. Systems integration: an effective and innovative response to emerging biological threats.

    PubMed

    House, Robert V

    2007-04-20

    A rapid and effective development of vaccines and other prophylactics, as well as novel therapeutics, against emerging threats requires the development and implementation of novel strategies. One such strategy is the integrator approach. This approach utilizes an integrated development team comprising expertise in program management, scientific management, clinical research, preclinical/nonclinical development, manufacturing, testing, risk management, quality assurance, and regulatory strategy and compliance. Key to the success of this approach is the successful management of subcontracted work, as well as the seamless integration of multiple systems and data inputs into a coherent development plan.

  13. Condition concern: an innovative response system for enhancing hospitalized patient care and safety.

    PubMed

    Baird, Sylvia K; Turbin, Lynn Bobel

    2011-01-01

    Patient safety is rapidly becoming everyone's responsibility. Bedside clinicians, physicians, and ancillary and administrative staff are well aware of their roles in patient safety, but patients and their families are becoming increasingly knowledgeable about potential safety issues related to hospitalization. This article describes how a Midwestern regional health care system enhances safety for its hospitalized patients through a program called "Condition Concern," designed to provide patients and their families/friends with a quick, convenient method for reporting unattended care concerns. The program's structure is described along with postimplementation findings to date. PMID:21233769

  14. Design of an Innovative Information System for the Intensive Care Unit in a Public Hospital.

    PubMed

    Tsoromokos, Dimitrios; Tsaloukidis, Nikolaos; Dermatis, Zacharias; Gozadinos, Filippos; Lazakidou, Athina

    2016-01-01

    The health sector is increasingly focused on the use of Communication Technology (ICT) Information and Communication. New technologies which introduced in health, should lead to lower cost of procedures, saving employees' working time and immediate and secure data storages for easy future search or meta-analysis. The DPP4ICU application which presented in this document, allows at the Intensive Care Unit's nurses (ICU) to enter directly the handwritten accountability, in the Organization Information System. Through this application is accelerated the proper completion of a document and is improved data quality. The application provides the ability to authorized users to exchange information with an automated manner. PMID:27350492

  15. Design of an Innovative Information System for the Intensive Care Unit in a Public Hospital.

    PubMed

    Tsoromokos, Dimitrios; Tsaloukidis, Nikolaos; Dermatis, Zacharias; Gozadinos, Filippos; Lazakidou, Athina

    2016-01-01

    The health sector is increasingly focused on the use of Communication Technology (ICT) Information and Communication. New technologies which introduced in health, should lead to lower cost of procedures, saving employees' working time and immediate and secure data storages for easy future search or meta-analysis. The DPP4ICU application which presented in this document, allows at the Intensive Care Unit's nurses (ICU) to enter directly the handwritten accountability, in the Organization Information System. Through this application is accelerated the proper completion of a document and is improved data quality. The application provides the ability to authorized users to exchange information with an automated manner.

  16. A system-wide innovation in transition services: transforming the home care liaison role.

    PubMed

    Meadows, Carl A; Fraser, Julie; Camus, Susann; Henderson, Kathy

    2014-02-01

    This article describes how a provincial health authority in Canada improved patient care and staff satisfaction by transforming the role of home care (HC) liaison. The transformation focused on clearly defining the role, function and reporting structure, and identifying which healthcare providers could fill the liaison role. The transformation included adoption of transition best practices, leveraging an electronic referral system, creation of an interprofessional team, standardization of tools/orientation, and strong evaluation metrics, centralizing decision making, and developing a process for streaming referrals. The authors identify key success factors that made the transformation possible, as well as challenges and work that remains to sustain the change.

  17. A New and Innovative Use of the Thermal Knife and Kevlar Cord Components in a Restraint and Release System

    NASA Technical Reports Server (NTRS)

    Stewart, Alphonso; Brodeur, Stephen J. (Technical Monitor)

    2001-01-01

    A Kevlar cord and two thermal knives are key components in the Soar Array Restraint and Release System (SARRS) on the Microwave Anisotropy Probe (MAP) spacecraft at NASA's Goddard Space Flight Center. The SARRS uses a 25-foot (7.62 m) length Kevlar cord that encircles the spacecraft and secures the solar panels in stowed configuration for launch. Once in orbit, one of two redundantly configured thermal knives severs the Kevlar cord and permits the panels to deploy. The purpose of this paper is to present the details of the design, development test results, and the various innovations that were created during the development of this novel use of the thermal knife and Kevlar cord.

  18. Potential for Layered Double Hydroxides-Based, Innovative Drug Delivery Systems

    PubMed Central

    Zhang, Kai; Xu, Zhi Ping; Lu, Ji; Tang, Zhi Yong; Zhao, Hui Jun; Good, David A.; Wei, Ming Qian

    2014-01-01

    Layered Double Hydroxides (LDHs)-based drug delivery systems have, for many years, shown great promises for the delivery of chemical therapeutics and bioactive molecules to mammalian cells in vitro and in vivo. This system offers high efficiency and drug loading density, as well as excellent protection of loaded molecules from undesired degradation. Toxicological studies have also found LDHs to be biocompatible compared with other widely used nanoparticles, such as iron oxide, silica, and single-walled carbon nanotubes. A plethora of bio-molecules have been reported to either attach to the surface of or intercalate into LDH materials through co-precipitation or anion-exchange reaction, including amino acid and peptides, ATPs, vitamins, and even polysaccharides. Recently, LDHs have been used for gene delivery of small molecular nucleic acids, such as antisense, oligonucleotides, PCR fragments, siRNA molecules or sheared genomic DNA. These nano-medicines have been applied to target cells or organs in gene therapeutic approaches. This review summarizes current progress of the development of LDHs nanoparticle drug carriers for nucleotides, anti-inflammatory, anti-cancer drugs and recent LDH application in medical research. Ground breaking studies will be highlighted and an outlook of the possible future progress proposed. It is hoped that the layered inorganic material will open up new frontier of research, leading to new nano-drugs in clinical applications. PMID:24786098

  19. Public outcomes: Building a 21st century national innovation system that serves the public

    SciTech Connect

    Gover, J.; Huray, P.; Carayannis, E.

    1997-09-01

    Federal R and D must be principally focused on solving public problems that the marketplace is failing to address. With few exceptions programs must be supported by roadmaps that show how the R and D is linked to public outcomes. Federal R and D and those who perform it must be judged in terms of the public outcomes. The overarching issues of federal R and D policy, what it should address, how to manage it, who should perform it, how to perform it, what works best, etc. are highly complex and lack a strong theoretical foundation. (In fact, the linear, assembly-line model used by policymakers is wrong.) It is time that policymakers recognize and acknowledge the uncertainty of their work and conduct a wide array of policy experiments (the authors consider SEMATECH such an experiment) that are supported by public outcome metrics. In addition to making federal R and D better address public needs, such an approach to policy making could raise the public`s interest in T and S policy. Of course, as in any experiment the results may be measured and if failures aren`t observed, it is likely that policies lack vision and imagination. It is time to abandon the budget driven federal R and D system where performers of federal R and D are treated as constituents, and replace it with a public problem--public outcome driven system where public problems are prioritized and the budget is distributed to agencies according to these priorities.

  20. Development of an oscillating-vane concept as an innovative wind-energy-conversion system

    SciTech Connect

    Bielawa, R.L.

    1982-03-01

    The practicality is investigated of an oscillating vane wind energy conversion system, which incorporated the bending-torsion flutter characteristics of a cantilevered wing. The system, characterized by relatively large response amplitudes, employs a construction scheme based on the high fatigue strength characteristics of a composite material. Results are presented of experimental and analytic studies to provide technical data upon which we can assess the concept. Two variants of the concepts are examined: single-vane and split-vane configurations. The experimental results consist of the mechanical power generation and dynamic response and stress characteristics for a model having a span of approximately one meter. Two complementary analyses are described: (1) a linear flutter eigensolution to calculate conditions for self-start and flutter response amplitude ratios; and (2) a nonlinear time-history analysis to calculate output power characteristics. Results of correlation studies of these analyses with the acquired test data are presented. It is concluded that the concept is technically practical.

  1. Potential for layered double hydroxides-based, innovative drug delivery systems.

    PubMed

    Zhang, Kai; Xu, Zhi Ping; Lu, Ji; Tang, Zhi Yong; Zhao, Hui Jun; Good, David A; Wei, Ming Qian

    2014-01-01

    Layered Double Hydroxides (LDHs)-based drug delivery systems have, for many years, shown great promises for the delivery of chemical therapeutics and bioactive molecules to mammalian cells in vitro and in vivo. This system offers high efficiency and drug loading density, as well as excellent protection of loaded molecules from undesired degradation. Toxicological studies have also found LDHs to be biocompatible compared with other widely used nanoparticles, such as iron oxide, silica, and single-walled carbon nanotubes. A plethora of bio-molecules have been reported to either attach to the surface of or intercalate into LDH materials through co-precipitation or anion-exchange reaction, including amino acid and peptides, ATPs, vitamins, and even polysaccharides. Recently, LDHs have been used for gene delivery of small molecular nucleic acids, such as antisense, oligonucleotides, PCR fragments, siRNA molecules or sheared genomic DNA. These nano-medicines have been applied to target cells or organs in gene therapeutic approaches. This review summarizes current progress of the development of LDHs nanoparticle drug carriers for nucleotides, anti-inflammatory, anti-cancer drugs and recent LDH application in medical research. Ground breaking studies will be highlighted and an outlook of the possible future progress proposed. It is hoped that the layered inorganic material will open up new frontier of research, leading to new nano-drugs in clinical applications.

  2. Self-monitoring surveillance system for prestressing tendons. Phase I small business innovation research

    SciTech Connect

    Tabatabai, H.

    1995-12-01

    Assured safety and operational reliability of post-tensioned concrete components of nuclear power plants are of great significance to the public, electric utilities, and regulatory agencies. Prestressing tendons provide principal reinforcement for containment and other structures. In this phase of the research effort, the feasibility of developing a passive surveillance system for identification of ruptures in tendon wires was evaluated and verified. The concept offers high potential for greatly increasing effectiveness of presently-utilized periodic tendon condition surveillance programs. A one-tenth scale ring model of the Palo Verde nuclear containment structure was built inside the Structural Laboratory. Dynamic scaling (similitude) relationships were used to relate measured sensor responses recorded during controlled wire breakages to the expected prototype containment tendon response. Strong and recognizable signatures were detected by the accelerometers used. It was concluded that the unbonded prestressing tendons provide an excellent path for transmission of stress waves resulting from wire breaks. Accelerometers placed directly on the bearing plates at the ends of tendons recorded high-intensity waveforms. Accelerometers placed elsewhere on concrete surfaces of the containment model revealed substantial attenuation and reduced intensities of captured waveforms. Locations of wire breaks could be determined accurately through measurement of differences in arrival times of the signal at the sensors. Pattern recognition systems to be utilized in conjunction with the proposed concept will provide a basis for an integrated and automated tool for identification of wire breaks.

  3. Driving Innovation in Health Systems through an Apps-Based Information Economy

    PubMed Central

    Mandel, Joshua C.; Kohane, Isaac S.

    2015-01-01

    Healthcare data will soon be accessible using standard, open software interfaces. Here, we describe how these interfaces could lead to improved healthcare by facilitating the development of software applications (apps) that can be shared across physicians, health care organizations, translational researchers, and patients. We provide recommendations for next steps and resources for the myriad stakeholders. If challenges related to efficacy, accuracy, utility, safety, privacy, and security can be met, this emerging apps model for health information technology will open up the point of care for innovation and connect patients at home to their healthcare data. PMID:26339683

  4. Imaging System

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The 1100C Virtual Window is based on technology developed under NASA Small Business Innovation (SBIR) contracts to Ames Research Center. For example, under one contract Dimension Technologies, Inc. developed a large autostereoscopic display for scientific visualization applications. The Virtual Window employs an innovative illumination system to deliver the depth and color of true 3D imaging. Its applications include surgery and Magnetic Resonance Imaging scans, viewing for teleoperated robots, training, and in aviation cockpit displays.

  5. Why Groundwater Matters: An Innovative Look at Pumping, Irrigation, System Dynamics and Sustainability

    NASA Astrophysics Data System (ADS)

    Condon, L. E.; Maxwell, R. M.

    2013-12-01

    Regional impacts from irrigation and groundwater pumping have been the subject of much research. Connections between pumping, drawdown, increased evapotranspiration and decreased runoff are well established; however, the effect of groundwater fed irrigation on system dynamics has not been explored thoroughly and has potentially important implications for the ability of a watershed to respond to stress as well as future sustainability. We use a fully-integrated hydrologic model, ParFlow, to simulate moisture-dependent irrigation in the Little Washita basin USA. Three, twenty-year simulations are completed for the ~1,700 km2 domain using hourly historical meteorological forcings from 1990 to 2009 for three scenarios with varying levels of farm coverage. As would be expected, analysis shows spatiotemporal variability at a range of frequencies and correlation lengths. However, local behavior is highly variable and can be impacted by a number of physical parameters and transient forcings. To better quantify system behavior, a classification scheme was developed that groups time series based on annual trends and the ratio of intra-annual variability to inter-annual variability. This scheme is demonstrated using time series of end of month water table depth. Analysis, of the baseline scenario with no agriculture shows spatial organization of classification groups. Along the river, where groundwater is shallow, water table depths have a strong intra-annual cycle but relatively constant long term average. Conversely, near the hilltops, where the water table is deepest, monthly variability is small compared to the longer term oscillations. Contrasting classifications from the baseline case to the irrigation scenarios, there are significant shifts in water table dynamics. The imposition of an annual pumping cycle in a small portion of the domain (~10 - 23%) leads to larger intra-annual variability throughout nearly the entire study area and increases the area where intra

  6. Energy Efficient Building Ventilation Systems: Innovative Building-Integrated Enthalpy Recovery

    SciTech Connect

    2010-10-15

    BEETIT Project: A2 is developing a building moisture and heat exchange technology that leverages a new material and design to create healthy buildings with lower energy use. Commercial building owners/operators are demanding buildings with greater energy efficiency and healthier indoor environments. A2 is developing a membrane-based heat and moisture exchanger that controls humidity by transferring the water vapor in the incoming fresh air to the drier air leaving the building. Unlike conventional systems, A2 locates the heat and moisture exchanger within the depths of the building’s wall to slow down the air flow and increase the surface area that captures humidity, but with less fan power. The system’s integration into the wall reduces the size and demand on the air conditioning equipment and increases liable floor area flexibility.

  7. Investigation of performances of innovative aeronautic injection systems using advanced laser diagnostics

    NASA Astrophysics Data System (ADS)

    Orain, M.; Grisch, F.; Jourdanneau, E.; Rossow, B.; Guin, C.; Trétout, B.

    2011-10-01

    Simultaneous measurements of Planar Laser-Induced Fluorescence (PLIF) kerosene and PLIF-OH have been successfully performed in a multipoint injection system for various overall equivalence ratios, air inlet temperatures between 480 and 730 K, and pressures up to 2.2 MPa. Single-shot two-dimensional (2D) maps of the spatial distribution of kerosene vapor and OH radical in the combustor have been recorded with good signal-to-noise ratio. Results show that depending on the split between the pilot and the main injectors, the flame front exhibits either a single or a double structure. Good spatial correlation between the repartition of kerosene vapor and the position of the flame front was observed; in particular, no "dark zone" is observed between the fuel and the flame front. As temperature and pressure increase, fuel evaporation improves and the spatial distribution of OH radical becomes more homogeneous in the combustor, suggesting a partially-distributed combustion.

  8. [The histaminergic system: a target for innovative treatments of cognitive deficits].

    PubMed

    Motawaj, Mouhammad; Burban, Aude; Davenas, Elisabeth; Gbahou, Florence; Faucard, Raphaël; Morisset, Séverine; Arrang, Jean-Michel

    2010-01-01

    The central effects of histamine are mediated by H(1), H(2) and H(3) receptors. The H(3) receptor inhibits histamine release in brain. Therefore, H(3) receptor inverse agonists, by suppressing this brake, enhance histamine neuron activity. The histaminergic system plays a major role in cognition and H(3) receptor inverse agonists are expected to be a potential therapeutics for cognitive deficits of Alzheimer's disease (AD). They are eagerly awaited inasmuch as other treatments of the disease, such as tacrine or memantine, also enhance, through different mechanisms, histaminergic neurotransmission. An important loss of histaminergic neurons has been observed in AD. In contrast, levels of the histamine metabolite in the CSF of AD patients show that their global activity is decreased by only 25%. This indicates that activating histamine neurons in AD can be envisaged.

  9. Subsurface volatilization and ventilation system (SVVS) (trade name): Innovative technology evaluation report

    SciTech Connect

    King, J.; Beckman, S.; Kitaplioqlu, O.

    1995-08-01

    This report summarizes the findings of a Demonstration Test of Brown and Root Environmental`s Subsurface Volatilization and Ventilation System (SVVS) process. Under the SITE program, the technology was evaluated to determine its effectiveness in reducing volatile organic contamination in the vadose zone of the former `dry well area` of the Electro-Voice facility after one year of treatment. The SVVS process is an integrated technology that utilizes the benefits of soil vapor extraction/air sparging and in-situ bioremediation for the treatment of subsurface organic contamination in soil and groundwater. Demonstration results showed that the SVVS achieved an overall 80.6% reduction in the sum of the seven critical VOCs in the vadose zone, exceeding the vendors claims. Reductions of 81.5% were achieved in the `sludge` layer, and between 97.8% and 99.8% for the other vadose zone layers.

  10. The Geologist's Field Assistant: Developing an Innovative Science Analysis System for Exploring the Surface of Mars

    NASA Astrophysics Data System (ADS)

    Gulick, V. C.; Morris, R. L.; Gazis, P. R.; Bishop, J. L.; Alena, R. L.

    2002-12-01

    We are developing science analysis algorithms to interface with a Geologist's Field Assistant (GFA) device that will allow robotic or human remote explorers to better sense and explore their surroundings during limited surface excursions. Our algorithms will interpret spectral and imaging data obtained by various sensors. The algorithms, for example, will identify key minerals, rocks, and sediments from mid-IR, Raman, and visible/near-IR spectra as well as from high-resolution and microscopic images to help interpret data and to provide high-level advice to the remote explorer. A key task for human or robotic explorers on the surface of Mars is choosing which particular rock or mineral samples should be selected for more intensive study. The usual challenges of such a task are compounded by the lack of sensory input available to a suited astronaut or the limited downlink bandwidth available to a rover. Additional challenges facing a human mission include limited surface time and the similarities in appearance of important minerals (e.g. carbonates, silicates, salts). Yet the choice of which sample to collect is critical. A top-level system allows multiple inputs from raw sensor data output by imagers and spectrometers (visible/near-IR, mid-IR, and Raman) as well as human opinion to identify rock and mineral samples. Our prototype image analysis system identifies some igneous and metamorphic rocks from texture and color information. Spectral analysis algorithms have also been developed that successfully identifiy quartz, silica polymorphs, calcite, pyroxene, and jarosite from both visible/near-IR and mid-IR spectra. We have also developed spectral recognizers that identify high-iron pyroxenes and iron-bearing minerals using visible/near-IR spectra only. We are building a combined image and spectral database of rocks and minerals with which to continue development of our algorithms. Future plans include developing algorithms to identify key igneous, sedimentary, and

  11. An innovative telescope control system architecture for SST-GATE telescopes at the CTA Observatory

    NASA Astrophysics Data System (ADS)

    Fasola, Gilles; Mignot, Shan; Laporte, Philippe; Abchiche, Abdel; Buchholtz, Gilles; Jégouzo, Isabelle

    2014-07-01

    SST-GATE (Small Size Telescope - GAmma-ray Telescope Elements) is a 4-metre telescope designed as a prototype for the Small Size Telescopes (SST) of the Cherenkov Telescope Array (CTA), a major facility for the very high energy gamma-ray astronomy of the next three decades. In this 100-telescope array there will be 70 SSTs, involving a design with an industrial view aiming at long-term service, low maintenance effort and reduced costs. More than a prototype, SST-GATE is also a fully functional telescope that shall be usable by scientists and students at the Observatoire de Meudon for 30 years. The Telescope Control System (TCS) is designed to work either as an element of a large array driven by an array controller or in a stand-alone mode with a remote workstation. Hence it is built to be autonomous with versatile interfacing; as an example, pointing and tracking —the main functions of the telescope— are managed onboard, including astronomical transformations, geometrical transformations (e.g. telescope bending model) and drive control. The core hardware is a CompactRIO (cRIO) featuring a real-time operating system and an FPGA. In this paper, we present an overview of the current status of the TCS. We especially focus on three items: the pointing computation implemented in the FPGA of the cRIO —using CORDIC algorithms— since it enables an optimisation of the hardware resources; data flow management based on OPCUA with its specific implementation on the cRIO; and the use of an EtherCAT field-bus for its ability to provide real-time data exchanges with the sensors and actuators distributed throughout the telescope.

  12. The Youth Nonfatal Violent Injury Review Panel: An Innovative Model to Inform Policy and Systems Change.

    PubMed

    Purtle, Jonathan; Rich, Linda J; Rich, John A; Cooper, Jazzmin; Harris, Erica J; Corbin, Theodore J

    2015-01-01

    Among young people in the United States, nonfatal violent injuries outnumber fatal violent injuries by 171 to 1. The Child Fatality Review Team (CFRT) is a well-established model for informing injury prevention planning. The CFRT's restricted focus on fatal injuries, however, limits its ability to identify opportunities to prevent violent reinjury and address issues unique to nonfatal violent injuries. We adapted the CFRT model to develop and implement a Youth Nonfatal Violent Injury Review Panel. We convened representatives from 23 agencies (e.g., police, housing, and education) quarterly to share administrative information and confidentially discuss cases of nonfatal violent injury. In this article, we describe the panel model and present preliminary data on participants' perceptions of the process. Although outcomes research is needed to evaluate its impacts, the Youth Nonfatal Violent Injury Review Panel offers an innovative, promising, and replicable model for interagency collaboration to prevent youth violence and its effects. PMID:26556932

  13. Balancing innovation and access to healthcare through the patent system--an Australian perspective.

    PubMed

    Nicol, Dianne

    2005-01-01

    This article examines the enforcement of gene and other research tool patents in Australia. An empirical analysis of patenting practices in the Australian medical biotechnology industry showed heightened concern about the impact of patents on research and diagnostic testing, but provided little evidence to support these concerns at that time. Since then, the Australian company Genetic Technologies Ltd. has been enforcing its patents for non-coding DNA sequences. The governments of Australia are encouraging the biotechnology industry to better protect and enforce intellectual property rights, but recognize these needs to be balanced against access to healthcare. The article discusses proposals made by the Australian Law Reform Commission to adjust the balance, both by tightening the requirements for obtaining patents and by introducing various options to assist providers of diagnostic services and others in using patented inventions, but at the same time maintaining the incentive to innovate.

  14. Experimental and Analytical Seismic Studies of a Four-Span Bridge System with Innovative Materials

    NASA Astrophysics Data System (ADS)

    Cruz Noguez, Carlos Alonso

    As part of a multi-university project utilizing the NSF Network for Earthquake Engineering Simulation (NEES), a quarter-scale model of a four-span bridge incorporating plastic hinges with different advanced materials was tested to failure on the three shake table system at the University of Nevada, Reno (UNR). The bridge was the second test model in a series of three 4-span bridges, with the first model being a conventional reinforced-concrete (RC) structure. The purpose of incorporating advanced materials was to improve the seismic performance of the bridge with respect to two damage indicators: (1) column damage and (2) permanent deformations. The goals of the study presented in this document were to (1) evaluate the seismic performance of a 4-span bridge system incorporating SMA/ECC and built-in rubber pad plastic hinges as well as post-tensioned piers, (2) quantify the relative merit of these advanced materials and details compared to each other and to conventional reinforced concrete plastic hinges, (3) determine the influence of abutment-superstructure interaction on the response, (4) examine the ability of available elaborate analytical modeling techniques to model the performance of advanced materials and details, and (5) conduct an extensive parametric study of different variations of the bridge model to study several important issues in bridge earthquake engineering. The bridge model included six columns, each pair of which utilized a different advanced detail at bottom plastic hinges: shape memory alloys (SMA), special engineered cementitious composites (ECC), elastomeric pads embedded into columns, and post-tensioning tendons. The design of the columns, location of the bents, and selection of the loading protocol were based on pre-test analyses conducted using computer program OpenSees. The bridge model was subjected to two-horizontal components of simulated earthquake records of the 1994 Northridge earthquake. Over 340 channels of data were collected

  15. Project Aryavarta: A Novel approach in Innovative and energy efficient space transportation systems

    NASA Astrophysics Data System (ADS)

    Ghadawala, Rushi; Chokshi, Poojan; Verma, Rajeev

    With the advancement of technology, there is a growing interest about other planets and so it would be necessary to shift the scientific analysis activities from the earth's orbit to that of other planets. The main aim of project ARYAVARTA is to shift a satellite orbit from one planet to another with the help of an Unmanned Space Vehicle (USV). For example, to shift scientific activities economically to other planets, we need to change the orbit of the satellite from earth to that of the other planet instead of sending separate space probes, as that would entail comparatively much higher cost. A solar powered USV is one that will be having ion propulsion system along with solar propulsion system. The USV, placed in rocket boosters, will be externally launched like a space shuttle to enable it to go beyond the atmospheric limit of the earth with sufficient escape velocity. Xenon cylinders attached to the USV will provide ion propulsion for furthering the mission. The USV will then be attached to the satellite revolving in the orbit of the earth. The satellite which is attached to the USV will be de-orbited with the help of xenon engines, and will be shifted to another orbit of another planet/satellite. Electricity generated by solar panels, made from multicrystalline solar cells, of the USV will be stored in the USV to help the mission/operational requirements. With the help of multireflectors, the reflected solar rays will be re-concentrated to the solar panel and hence, power efficiency will increase more than twice. Solar-electromagnetic propulsion would make such a mission possible because an ion engine can run almost continuously and outperform any chemical rocket for such long flights. This project will help to achieve higher efficiency with great economy, and eliminate the need for sending extra space probes for any other mission. As xenon engine occupies lesser room than conventional engines, more compact instruments will emerge ahead resulting in the

  16. Innovative system for real-time ergonomic feedback in industrial manufacturing.

    PubMed

    Vignais, Nicolas; Miezal, Markus; Bleser, Gabriele; Mura, Katharina; Gorecky, Dominic; Marin, Frédéric

    2013-07-01

    This work presents a system that permits a real-time ergonomic assessment of manual tasks in an industrial environment. First, a biomechanical model of the upper body has been developed by using inertial sensors placed at different locations on the upper body. Based on this model, a computerized RULA ergonomic assessment was implemented to permit a global risk assessment of musculoskeletal disorders in real-time. Furthermore, local scores were calculated per segment, e.g. the neck region, and gave information on the local risks for musculoskeletal disorders. Visual information was fed back to the user by using a see-through head mounted display. Additional visual highlighting and auditory warnings were provided when some predefined thresholds were exceeded. In a user study (N = 12 participants) a group with the RULA feedback was compared to a control group. Results demonstrate that the real-time ergonomic feedback significantly decreased the outcome of both globally as well as locally hazardous RULA values that are associated with increased risk for musculoskeletal disorders. Task execution time did not differ between groups. The real-time ergonomic tool introduced in this study has the potential to considerably reduce the risk of musculoskeletal disorders in industrial settings. Implications for ergonomics in manufacturing and user feedback modalities are further discussed.

  17. Innovative system for real-time ergonomic feedback in industrial manufacturing.

    PubMed

    Vignais, Nicolas; Miezal, Markus; Bleser, Gabriele; Mura, Katharina; Gorecky, Dominic; Marin, Frédéric

    2013-07-01

    This work presents a system that permits a real-time ergonomic assessment of manual tasks in an industrial environment. First, a biomechanical model of the upper body has been developed by using inertial sensors placed at different locations on the upper body. Based on this model, a computerized RULA ergonomic assessment was implemented to permit a global risk assessment of musculoskeletal disorders in real-time. Furthermore, local scores were calculated per segment, e.g. the neck region, and gave information on the local risks for musculoskeletal disorders. Visual information was fed back to the user by using a see-through head mounted display. Additional visual highlighting and auditory warnings were provided when some predefined thresholds were exceeded. In a user study (N = 12 participants) a group with the RULA feedback was compared to a control group. Results demonstrate that the real-time ergonomic feedback significantly decreased the outcome of both globally as well as locally hazardous RULA values that are associated with increased risk for musculoskeletal disorders. Task execution time did not differ between groups. The real-time ergonomic tool introduced in this study has the potential to considerably reduce the risk of musculoskeletal disorders in industrial settings. Implications for ergonomics in manufacturing and user feedback modalities are further discussed. PMID:23261177

  18. Dual Arm Work Platform teleoperated robotics system. Innovative technology summary report

    SciTech Connect

    1998-12-01

    The US Department of Energy (DOE) and the Federal Energy Technology Center (FETC) has developed a Large Scale Demonstration Project (LSDP) at the Chicago Pile-5 Research Reactor (CP-5) at Argonne National Laboratory-East (ANL). The objective of the LSDP is to demonstrate potentially beneficial Deactivation and Decommissioning (D and D) technologies in comparison with current baseline technologies. The Dual Arm Work Platform (DAWP) demonstration focused on the use of the DAWP to segment and dismantle the CP-5 reactor tank and surrounding bio-shield components (including the graphite block reflector, lead and boral sheeting) and performing some minor tasks best suited for the use of teleoperated robotics that were not evaluated in this demonstration. The DAWP system is not a commercially available product at this time. The CP-5 implementation was its first D and D application. The demonstration of the DAWP was to determine the areas on which improvements must be made to make this technology commercially viable. The results of the demonstration are included in this greenbook. It is the intention of the developers to incorporate lessons learned at this demonstration and current technological advancements in robotics into the next generation of the DAWP.

  19. M-BAND IMAGING OF THE HR 8799 PLANETARY SYSTEM USING AN INNOVATIVE LOCI-BASED BACKGROUND SUBTRACTION TECHNIQUE

    SciTech Connect

    Galicher, Raphael; Marois, Christian; Macintosh, Bruce; Konopacky, Quinn; Barman, Travis

    2011-10-01

    Multi-wavelength observations/spectroscopy of exoplanetary atmospheres are the basis of the emerging exciting field of comparative exoplanetology. The HR 8799 planetary system is an ideal laboratory to study our current knowledge gap between massive field brown dwarfs and the cold 5 Gyr old solar system planets. The HR 8799 planets have so far been imaged at J- to L-band, with only upper limits available at M-band. We present here deep high-contrast Keck II adaptive optics M-band observations that show the imaging detection of three of the four currently known HR 8799 planets. Such detections were made possible due to the development of an innovative LOCI-based background subtraction scheme that is three times more efficient than a classical median background subtraction for Keck II AO data, representing a gain in telescope time of up to a factor of nine. These M-band detections extend the broadband photometric coverage out to {approx}5 {mu}m and provide access to the strong CO fundamental absorption band at 4.5 {mu}m. The new M-band photometry shows that the HR 8799 planets are located near the L/T-type dwarf transition, similar to what was found by other studies. We also confirm that the best atmospheric fits are consistent with low surface gravity, dusty, and non-equilibrium CO/CH{sub 4} chemistry models.

  20. Evaluation of the Relative Contribution of Observing Systems in Reanalyses: Aircraft Temperature Bias and Analysis Innovations (Invited)

    NASA Astrophysics Data System (ADS)

    Bosilovich, M. G.; da Silva, A.

    2013-12-01

    Reanalyses have become important sources of data in weather and climate research. While observations are the most crucial component of the systems, few research projects consider carefully the multitudes of assimilated observations and their impact on the results. This is partly due to the diversity of observations and their individual complexity, but also due to the unfriendly nature of the data formats. Here, we discuss the NASA Modern-Era Retrospective analysis for Research and Applications (MERRA) and a companion dataset, the Gridded Innovations and Observations (GIO). GIO is simply a post-processing of the assimilated observations and their innovations (forecast departure and analysis departure) to a common spatio-temporal grid, following that of the MERRA analysis fields. The data includes insitu, retrieved and radiance observations that are assimilated and used in the reanalysis. While all these disparate observations and statistics are in a uniform easily accessible format, there are some limitations. Similar observations are binned to the grid, so that multiple observations are combined in the gridding process. The data are then implicitly thinned. Some details in the meta data may also be lost (e.g. aircraft or station ID). Nonetheless, the gridded observations should provide simplified access to all the observations input to the reanalysis. To provide an example of the GIO data, a case study evaluating observing systems over the United States and statistics is presented, and demonstrates the evaluation of the observations and the data assimilation. The GIO data are used to collocate Radiosonde and Aircraft temperature measurements from 1979-2012. Using the observed residuals from the MERRA data assimilation, we statistically infer the contextual bias and effective gain for various observing systems. A known warm bias of the aircraft measurements is apparent compared to the radiosonde data forecast departures. However, when larger quantities of aircraft

  1. HPTLC-aptastaining – Innovative protein detection system for high-performance thin-layer chromatography

    NASA Astrophysics Data System (ADS)

    Morschheuser, Lena; Wessels, Hauke; Pille, Christina; Fischer, Judith; Hünniger, Tim; Fischer, Markus; Paschke-Kratzin, Angelika; Rohn, Sascha

    2016-05-01

    Protein analysis using high-performance thin-layer chromatography (HPTLC) is not commonly used but can complement traditional electrophoretic and mass spectrometric approaches in a unique way. Due to various detection protocols and possibilities for hyphenation, HPTLC protein analysis is a promising alternative for e.g., investigating posttranslational modifications. This study exemplarily focused on the investigation of lysozyme, an enzyme which is occurring in eggs and technologically added to foods and beverages such as wine. The detection of lysozyme is mandatory, as it might trigger allergenic reactions in sensitive individuals. To underline the advantages of HPTLC in protein analysis, the development of innovative, highly specific staining protocols leads to improved sensitivity for protein detection on HPTLC plates in comparison to universal protein derivatization reagents. This study aimed at developing a detection methodology for HPTLC separated proteins using aptamers. Due to their affinity and specificity towards a wide range of targets, an aptamer based staining procedure on HPTLC (HPTLC-aptastaining) will enable manifold analytical possibilities. Besides the proof of its applicability for the very first time, (i) aptamer-based staining of proteins is applicable on different stationary phase materials and (ii) furthermore, it can be used as an approach for a semi-quantitative estimation of protein concentrations.

  2. Energy at the Frontier: Low Carbon Energy System Transitions and Innovation in Four Prime Mover Countries

    NASA Astrophysics Data System (ADS)

    Araujo, Kathleen M.

    All too often, discussion about the imperative to change national energy pathways revolves around long timescales and least cost economics of near-term energy alternatives. While both elements certainly matter, they don't fully reflect what can drive such development trajectories. This study explores national energy transitions by examining ways in which four prime mover countries of low carbon energy technology shifted away from fossil fuels, following the first global oil crisis of 1973. The research analyzes the role of readiness, sectoral contributions and adaptive policy in the scale-up and innovations of advanced, alternative energy technologies. Cases of Brazilian biofuels, Danish wind power, French nuclear power and Icelandic geothermal energy are analyzed for a period of four decades. Fundamentally, the research finds that significant change can occur in under 15 years; that technology complexity need not necessarily impede change; and that countries of different governance approaches and consumption levels can effectuate such transitions. This research also underscores that low carbon energy technologies may be adopted before they are competitive and then become competitive in the process. (Copies available exclusively from MIT Libraries, libraries.mit.edu/docs - docs mit.edu)

  3. Innovative use of lamella clarifiers for central stormwater treatment in separate sewer systems.

    PubMed

    Weiss, Gebhard

    2014-01-01

    Lamella settlers have been used in the past few years for the sedimentation of particles in wastewater and stormwater applications. A new and very innovative approach for the treatment of stormwater flows is proposed which extends the portfolio of solutions beyond traditional settling tanks. Surface runoff is stored in a sewer or a basin and finally treated in a small but continuously operated lamella clarifier. The low throughput flow will yield good treatment efficiency at a small footprint. The possibilities of using existing storage volume in a storm sewer, as well as the structural flexibility of the arrangement are decisive benefits. As a large operational advantage, the lamellae may be cleaned mechanically, e.g. by pivoting under water. Finally, the flow and the sludge which will be sent to the downstream treatment plant will be minimized. A new comparative simulation method is proposed in order to assess an equivalent degree of stormwater treatment, either by achieving an equal annual volume of treated stormwater or, more directly, an equal amount of spilled pollutant load. The new solution is compared with a traditional settling tank according to current German design rules. Additionally, a case study from a real installation will be presented.

  4. KRISTINA: Kinematic rib-based structural system for innovative adaptive trailing edge

    NASA Astrophysics Data System (ADS)

    Pecora, R.; Amoroso, F.; Magnifico, M.; Dimino, I.; Concilio, A.

    2016-04-01

    Nature teaches that the flight of the birds succeeds perfectly since they are able to change the shape of their wings in a continuous manner. The careful observation of this phenomenon has re-introduced in the recent research topics the study of "metamorphic" wing structures; these innovative architectures allow for the controlled wing shape adaptation to different flight conditions with the ultimate goal of getting desirable improvements such as the increase of aerodynamic efficiency or load control effectiveness. In this framework, the European research project SARISTU aimed at combining morphing and smart ideas to the leading edge, the trailing edge and the winglet of a large commercial airplane (EASA CS25 category) while assessing integrated technologies validation through high-speed wind tunnel test on a true scale outer wing segment. The design process of the adaptive trailing edge (ATED) addressed by SARISTU is here outlined, from the conceptual definition of the camber-morphing architecture up to the assessment of the device executive layout. Rational design criteria were implemented in order to preliminarily define ATED structural layout and the general configuration of the embedded mechanisms enabling morphing under the action of aerodynamic loads. Advanced FE analyses were then carried out and the robustness of adopted structural arrangements was proven in compliance with applicable airworthiness requirements.

  5. HPTLC-aptastaining – Innovative protein detection system for high-performance thin-layer chromatography

    PubMed Central

    Morschheuser, Lena; Wessels, Hauke; Pille, Christina; Fischer, Judith; Hünniger, Tim; Fischer, Markus; Paschke-Kratzin, Angelika; Rohn, Sascha

    2016-01-01

    Protein analysis using high-performance thin-layer chromatography (HPTLC) is not commonly used but can complement traditional electrophoretic and mass spectrometric approaches in a unique way. Due to various detection protocols and possibilities for hyphenation, HPTLC protein analysis is a promising alternative for e.g., investigating posttranslational modifications. This study exemplarily focused on the investigation of lysozyme, an enzyme which is occurring in eggs and technologically added to foods and beverages such as wine. The detection of lysozyme is mandatory, as it might trigger allergenic reactions in sensitive individuals. To underline the advantages of HPTLC in protein analysis, the development of innovative, highly specific staining protocols leads to improved sensitivity for protein detection on HPTLC plates in comparison to universal protein derivatization reagents. This study aimed at developing a detection methodology for HPTLC separated proteins using aptamers. Due to their affinity and specificity towards a wide range of targets, an aptamer based staining procedure on HPTLC (HPTLC-aptastaining) will enable manifold analytical possibilities. Besides the proof of its applicability for the very first time, (i) aptamer-based staining of proteins is applicable on different stationary phase materials and (ii) furthermore, it can be used as an approach for a semi-quantitative estimation of protein concentrations. PMID:27220270

  6. Disruptive Innovation: Implementation of Electronic Consultations in a Veterans Affairs Health Care System

    PubMed Central

    Clark, Justice

    2016-01-01

    Background Electronic consultations (e-consults) offer rapid access to specialist input without the need for a patient visit. E-consult implementation began in 2011 at VA Boston Healthcare System (VABHS). By early 2013, e-consults were available for all clinical services. In this implementation, the requesting clinician selects the desired consultation within the electronic health record (EHR) ordering menu, which creates an electronic form that is pre-populated with patient demographic information and allows free-text entry of the reason for consult. This triggers a message to the requesting clinician and requested specialty, thereby enabling bidirectional clinician-clinician communication. Objective The aim of this study is to examine the utilization of e-consults in a large Veterans Affairs (VA) health care system. Methods Data from the electronic health record was used to measure frequency of e-consult use by provider type (physician or nurse practitioner (NP) and/or physician assistant), and by the requesting and responding specialty from January 2012 to December 2013. We conducted chart reviews for a purposive sample of e-consults and semi-structured interviews with a purposive sample of clinicians and hospital leaders to better characterize the process, challenges, and usability of e-consults. Results A total of 7097 e-consults were identified, 1998 from 2012 and 5099 from 2013. More than one quarter (27.56%, 1956/7097) of the e-consult requests originated from VA facilities in New England other than VABHS and were excluded from subsequent analysis. Within the VABHS e-consults (72.44%, 5141/7097), variability in frequency and use of e-consults across provider types and specialties was found. A total of 64 NPs requested 2407 e-consults (median 12.5, range 1-415). In contrast, 448 physicians (including residents and fellows) requested 2349 e-consults (median 2, range 1-116). More than one third (37.35%, 1920/5141) of e-consults were sent from primary care to

  7. Student perceptions and effectiveness of an innovative learning tool: Anatomy Glove Learning System.

    PubMed

    Lisk, Kristina; McKee, Pat; Baskwill, Amanda; Agur, Anne M R

    2015-01-01

    A trend in anatomical education is the development of alternative pedagogical approaches to replace or complement experiences in a cadaver laboratory; however, empirical evidence on their effectiveness is often not reported. This study aimed to evaluate the effectiveness of Anatomy Glove Learning System (AGLS), which enables students to learn the relationship between hand structure and function by drawing the structures onto a worn glove with imprinted bones. Massage therapy students (n = 73) were allocated into two groups and drew muscles onto either: (1) the glove using AGLS instructional videos (3D group); or (2) paper with palmar/dorsal views of hand bones during an instructor-guided activity (2D group). A self-confidence measure and knowledge test were completed before, immediately after, and one-week following the learning conditions. Self-confidence of hand anatomy in the 3D group gradually increased (3.2/10, 4.7/10, and 4.8/10), whereas self-confidence in the 2D group began to decline one-week later (3.2/10, 4.4/10, and 3.9/10). Knowledge of hand anatomy improved in both groups immediately after learning, (P < 0.001). Students' perceptions of AGLS were also assessed using a 10-pt Likert scale evaluation questionnaire (10 = high). Students perceived the AGLS videos (mean = 8.3 ± 2.0) and glove (mean = 8.1 ± 1.8) to be helpful in improving their understanding of hand anatomy and the majority of students preferred AGLS as a learning tool (mean = 8.6 ± 2.2). This study provides evidence demonstrating that AGLS and the traditional 2D learning approach are equally effective in promoting students' self-confidence and knowledge of hand anatomy.

  8. Student perceptions and effectiveness of an innovative learning tool: Anatomy Glove Learning System.

    PubMed

    Lisk, Kristina; McKee, Pat; Baskwill, Amanda; Agur, Anne M R

    2015-01-01

    A trend in anatomical education is the development of alternative pedagogical approaches to replace or complement experiences in a cadaver laboratory; however, empirical evidence on their effectiveness is often not reported. This study aimed to evaluate the effectiveness of Anatomy Glove Learning System (AGLS), which enables students to learn the relationship between hand structure and function by drawing the structures onto a worn glove with imprinted bones. Massage therapy students (n = 73) were allocated into two groups and drew muscles onto either: (1) the glove using AGLS instructional videos (3D group); or (2) paper with palmar/dorsal views of hand bones during an instructor-guided activity (2D group). A self-confidence measure and knowledge test were completed before, immediately after, and one-week following the learning conditions. Self-confidence of hand anatomy in the 3D group gradually increased (3.2/10, 4.7/10, and 4.8/10), whereas self-confidence in the 2D group began to decline one-week later (3.2/10, 4.4/10, and 3.9/10). Knowledge of hand anatomy improved in both groups immediately after learning, (P < 0.001). Students' perceptions of AGLS were also assessed using a 10-pt Likert scale evaluation questionnaire (10 = high). Students perceived the AGLS videos (mean = 8.3 ± 2.0) and glove (mean = 8.1 ± 1.8) to be helpful in improving their understanding of hand anatomy and the majority of students preferred AGLS as a learning tool (mean = 8.6 ± 2.2). This study provides evidence demonstrating that AGLS and the traditional 2D learning approach are equally effective in promoting students' self-confidence and knowledge of hand anatomy. PMID:24757171

  9. The Personal Emergency Response System as a Technology Innovation in Primary Health Care Services: An Integrative Review

    PubMed Central

    2016-01-01

    Background Most western countries are experiencing greater pressure on community care services due to increased life expectancy and changes in policy toward prioritizing independent living. This has led to a demand for change and innovation in caring practices with an expected increased use of technology. Despite numerous attempts, it has proven surprisingly difficult to implement and adopt technological innovations. The main established technological innovation in home care services for older people is the personal emergency response system (PERS), which is widely adopted and used throughout most western countries aiming to support “aging safely in place.” Objective This integrative review examines how research literature describes use of the PERS focusing on the users’ perspective, thus exploring how different actors experience the technology in use and how it affects the complex interactions between multiple actors in caring practices. Methods The review presents an overview of the body of research on this well-established telecare solution, indicating what is important for different actors in regard to accepting and using this technology in community care services. An integrative review, recognized by a systematic search in major databases followed by a review process, was conducted. Results The search resulted in 33 included studies describing different actors’ experiences with the PERS in use. The overall focus was on the end users’ experiences and the consequences of having and using the alarm, and how the technology changes caring practices and interactions between the actors. Conclusions The PERS contributes to safety and independent living for users of the alarm, but there are also unforeseen consequences and possible improvements in the device and the integrated service. This rather simple and well-established telecare technology in use interacts with the actors involved, creating changes in daily living and even affecting their identities

  10. Earth System Science for Elementary Teachers: An Innovative Approach to Teacher Professional Development.

    NASA Astrophysics Data System (ADS)

    Purkiss, C.

    2015-12-01

    In many professional development programs, teachers attend workshops to learn new knowledge and skills and then are expected to go back to their classrooms and implement what they learned. Often skills or an activity is learned but does not necessarily get practiced in the classroom. Very few professional development programs add direct, immediate practice with children where teachers can try out immediately the new activities or the knowledge they have just learned. In this case, the program directors wanted to see that, by having children to practice with in a non-threatening, low stakes environment, if participants would incorporate the activities and knowledge learned during the workshop into their classrooms in a more immediate way. Would immediate practice help participants internalize the new knowledge and skills and thus create a fund of knowledge that they would use immediately on their return to the classroom. As part of a grant for professional development for underserved elementary teachers on climate literacy, an innovative children's camp was added to a summer intensive workshop. Prior to the summer workshop, participants completed an eight-week online graduate level course on the basics of inquiry-based science. Participants then attended the intensive three-week workshop to gain knowledge in weather and climate and how to teach these concepts in their classrooms. The workshop was rich in materials and resources for participants. During the third week of the workshop, teachers were camp leaders to 100 elementary students in grades 3 through 5 who were participating in "Climate Camp". Various evaluation and assessments were completed during the program on all participants. Through various evaluation methods, it was found that there was a positive transfer of knowledge to the classroom.

  11. An innovative early warning system for floods and operational risks in harbours

    NASA Astrophysics Data System (ADS)

    Smets, Steven; Bolle, Annelies; Mollaert, Justine; Buitrago, Saul; Gruwez, Vincent

    2016-04-01

    Early Warning Systems (EWS) are nowadays becoming fairly standard in river flood forecasting or in large scale hydrometeorological predictions. For complex coastal morphodynamic problems or in the vicinity of complex coastal structures, such as harbours, EWS are much less used because they are both technically and computationally still very challenging. To advance beyond the state-of-the-art, the EU FP7 project Risc-KIT (www.risc-kit.eu) is developing prototype EWS which address specifically these topics. This paper describes the prototype EWS which IMDC has developed for the case study site of the harbour of Zeebrugge. The harbour of Zeebrugge is the largest industrial seaport on the coast of Belgium, extending more than 3 km into the sea. Two long breakwaters provide shelter for the inner quays and docks for regular conditions and frequent storms. Extreme storms surges and waves can however still enter the harbour and create risks for the harbour operations and infrastructure. The prediction of the effects of storm surges and waves inside harbours are typically very complex and challenging, due to the need of different types of numerical models for representing all different physical processes. In general, waves inside harbours are a combination of locally wind generated waves and offshore wave penetration at the port entrance. During extreme conditions, the waves could overtop the quays and breakwaters and flood the port facilities. Outside a prediction environment, the conditions inside the harbour could be assessed by superimposing processes. The assessment can be carried out by using a combination of a spectral wave model (i.e. SWAN) for the wind generated waves and a Boussinesq type wave model (i.e. Mike 21 BW) for the wave penetration from offshore. Finally, a 2D hydrodynamic model (i.e. TELEMAC) can be used to simulate the overland flooding inside the port facilities. To reproduce these processes in an EWS environment, an additional challenge is to cope

  12. DUAL-MODE PROPULSION SYSTEM ENABLING CUBESAT EXPLORATION OF THE SOLAR SYSTEM NASA Innovative Advanced Concepts (NIAC) Phase I Final Report

    SciTech Connect

    Nathan Jerred; Troy Howe; Adarsh Rajguru; Dr. Steven Howe

    2014-06-01

    -based systems. The second scenario allows for the production of electrical power, which is then available for electric-based propulsion. Additionally, once at location the production of electrical power can be dedicated to the payload’s communication system for data transfer. Ultimately, the proposed dual-mode propulsion platform capitalizes on the benefits of two types of propulsion methods – the thrust of thermal propulsion ideal for quick orbital maneuvers and the specific impulse of electric propulsion ideal for efficient inter-planetary travel. Previous versions of this RTR-based concept have been studied for various applications [NETS 1-3]. The current version of this concept is being matured through a NASA Innovative Advanced Concepts (NIAC) Phase I grant, awarded for FY 2014. In this study the RTR concept is being developed to deliver a 6U CubeSat payload to the orbit of the Saturnian moon - Enceladus. Additionally, this study will develop an entire mission architecture for Enceladus targeting a total allowable launch mass of 1,000 kg.

  13. A Case Study Correlating Innovative Gamma Ray Scanning Detection Systems Data to Surface Soil Gamma Spectrometry Results - 13580

    SciTech Connect

    Thompson, Shannon; Rodriguez, Rene; Billock, Paul; Lit, Peter

    2013-07-01

    HydroGeoLogic (HGL), Inc. completed a United States Environmental Protection Agency (USEPA) study to characterize radiological contamination at a site near Canoga Park, California. The characterized area contained 470 acres including the site of a prototype commercial nuclear reactor and other nuclear design, testing, and support operations from the 1950's until 1988 [1]. The site history included radiological releases during operation followed by D and D activities. The characterization was conducted under an accelerated schedule and the results will support the project remediation. The project has a rigorous cleanup to background agenda and does not allow for comparison to risk-based guidelines. To target soil sample locations, multiple lines of evidence were evaluated including a gamma radiation survey, geophysical surveys, historical site assessment, aerial photographs, and former worker interviews. Due to the time since production and decay, the primary gamma emitting radionuclide remaining is cesium-137 (Cs-137). The gamma ray survey covered diverse, rugged terrain using custom designed sodium iodide thallium-activated (NaI(Tl)) scintillation detection systems. The survey goals included attaining 100% ground surface coverage and detecting gamma radiation as sensitively as possible. The effectiveness of innovative gamma ray detection systems was tested by correlating field Cs-137 static count ratios to Cs-137 laboratory gamma spectrometry results. As a case study, the area encompassing the former location of the first nuclear power station in the U. S. was scanned, and second by second global positioning system (GPS)-linked gamma spectral data were evaluated by examining total count rate and nuclide-specific regions of interest. To compensate for Compton scattering from higher energy naturally occurring radionuclides (U-238, Th-232 and their progeny, and K-40), count rate ratios of anthropogenic nuclide-specific regions of interest to the total count rate were

  14. MO-G-17A-01: Innovative High-Performance PET Imaging System for Preclinical Imaging and Translational Researches

    SciTech Connect

    Sun, X; Lou, K; Deng, Z; Shao, Y

    2014-06-15

    Purpose: To develop a practical and compact preclinical PET with innovative technologies for substantially improved imaging performance required for the advanced imaging applications. Methods: Several key components of detector, readout electronics and data acquisition have been developed and evaluated for achieving leapfrogged imaging performance over a prototype animal PET we had developed. The new detector module consists of an 8×8 array of 1.5×1.5×30 mm{sup 3} LYSO scintillators with each end coupled to a latest 4×4 array of 3×3 mm{sup 2} Silicon Photomultipliers (with ∼0.2 mm insensitive gap between pixels) through a 2.0 mm thick transparent light spreader. Scintillator surface and reflector/coupling were designed and fabricated to reserve air-gap to achieve higher depth-of-interaction (DOI) resolution and other detector performance. Front-end readout electronics with upgraded 16-ch ASIC was newly developed and tested, so as the compact and high density FPGA based data acquisition and transfer system targeting 10M/s coincidence counting rate with low power consumption. The new detector module performance of energy, timing and DOI resolutions with the data acquisition system were evaluated. Initial Na-22 point source image was acquired with 2 rotating detectors to assess the system imaging capability. Results: No insensitive gaps at the detector edge and thus it is capable for tiling to a large-scale detector panel. All 64 crystals inside the detector were clearly separated from a flood-source image. Measured energy, timing, and DOI resolutions are around 17%, 2.7 ns and 1.96 mm (mean value). Point source image is acquired successfully without detector/electronics calibration and data correction. Conclusion: Newly developed advanced detector and readout electronics will be enable achieving targeted scalable and compact PET system in stationary configuration with >15% sensitivity, ∼1.3 mm uniform imaging resolution, and fast acquisition counting rate

  15. Two Papers on Educational Innovation and Dissemination. 1. Educational Innovation: Substance and Process. 2. "Post-Sputnik" Trends in Educational Dissemination Systems.

    ERIC Educational Resources Information Center

    Paisley, Matilda B.; Paisley, William J.

    In the first paper of this set, a paradigm which was developed in communication and diffusion research is adapted to define the educational innovation process in the form of producer-product-dissemination-users-adoption. Dissemination and adoption are subject to a number of factors, which can be further detailed. Previously innovation was seen as…

  16. An Innovative System for the Efficient and Effective Treatment of Non-Traditional Waters for Reuse in Thermoelectric Power Generation

    SciTech Connect

    John Rodgers; James Castle

    2008-08-31

    This study assessed opportunities for improving water quality associated with coal-fired power generation including the use of non-traditional waters for cooling, innovative technology for recovering and reusing water within power plants, novel approaches for the removal of trace inorganic compounds from ash pond effluents, and novel approaches for removing biocides from cooling tower blowdown. This research evaluated specifically designed pilot-scale constructed wetland systems for treatment of targeted constituents in non-traditional waters for reuse in thermoelectric power generation and other purposes. The overall objective of this project was to decrease targeted constituents in non-traditional waters to achieve reuse criteria or discharge limitations established by the National Pollutant Discharge Elimination System (NPDES) and Clean Water Act (CWA). The six original project objectives were completed, and results are presented in this final technical report. These objectives included identification of targeted constituents for treatment in four non-traditional water sources, determination of reuse or discharge criteria for treatment, design of constructed wetland treatment systems for these non-traditional waters, and measurement of treatment of targeted constituents in non-traditional waters, as well as determination of the suitability of the treated non-traditional waters for reuse or discharge to receiving aquatic systems. The four non-traditional waters used to accomplish these objectives were ash basin water, cooling water, flue gas desulfurization (FGD) water, and produced water. The contaminants of concern identified in ash basin waters were arsenic, chromium, copper, mercury, selenium, and zinc. Contaminants of concern in cooling waters included free oxidants (chlorine, bromine, and peroxides), copper, lead, zinc, pH, and total dissolved solids. FGD waters contained contaminants of concern including arsenic, boron, chlorides, selenium, mercury

  17. Multilevel Dynamic Systems Affecting Introduction of HIV/STI Prevention Innovations among Chinese Women in Sex Work Establishments

    ERIC Educational Resources Information Center

    Weeks, Margaret R.; Li, Jianghong; Liao, Susu; Zhang, Qingning; Dunn, Jennifer; Wang, Yanhong; Jiang, Jingmei

    2013-01-01

    Social and public health scientists are increasingly interested in applying system dynamics theory to improve understanding and to harness the forces of change within complex, multilevel systems that affect community intervention implementation, effects, and sustainability. Building a system dynamics model based on ethnographic case study has the…

  18. School System Empires

    ERIC Educational Resources Information Center

    Huberman, Michael

    1972-01-01

    Although most educational systems are resistant to change, there are some features of the community, of the teachers, of government, and of the system that enable one to predict the likelihood of an innovation being accepted and implemented. (AL)

  19. The Indiana University Center for Healthcare Innovation and Implementation Science: Bridging healthcare research and delivery to build a learning healthcare system.

    PubMed

    Azar, Jose; Adams, Nadia; Boustani, Malaz

    2015-01-01

    In the United States, it is estimated that 75,000 deaths every year could be averted if the healthcare system implemented high quality care more effectively and efficiently. Patient harm in the hospital occurs as a consequence of inadequate procedures, medications and other therapies, nosocomial infections, diagnostic evaluations and patient falls. Implementation science, a new emerging field in healthcare, is the development and study of methods and tools aimed at enhancing the implementation of new discoveries and evidence into daily healthcare delivery. The Indiana University Center for Healthcare Innovation and Implementation Science (IU-CHIIS) was launched in September 2013 with the mission to use implementation science and innovation to produce great-quality, patient-centered and cost-efficient healthcare delivery solutions for the United States of America. Within the first 24 months of its initiation, the IU-CHIIS successfully scaled up an evidence-based collaborative care model for people with dementia and/or depression, successfully expanded the Accountable Care Unit model positively impacting the efficiency and quality of care, created the first Certificate in Innovation and Implementation Science in the US and secured funding from National Institutes of Health to investigate innovations in dementia care. This article summarizes the establishment of the IU-CHIIS, its impact and outcomes and the lessons learned during the journey.

  20. The Indiana University Center for Healthcare Innovation and Implementation Science: Bridging healthcare research and delivery to build a learning healthcare system.

    PubMed

    Azar, Jose; Adams, Nadia; Boustani, Malaz

    2015-01-01

    In the United States, it is estimated that 75,000 deaths every year could be averted if the healthcare system implemented high quality care more effectively and efficiently. Patient harm in the hospital occurs as a consequence of inadequate procedures, medications and other therapies, nosocomial infections, diagnostic evaluations and patient falls. Implementation science, a new emerging field in healthcare, is the development and study of methods and tools aimed at enhancing the implementation of new discoveries and evidence into daily healthcare delivery. The Indiana University Center for Healthcare Innovation and Implementation Science (IU-CHIIS) was launched in September 2013 with the mission to use implementation science and innovation to produce great-quality, patient-centered and cost-efficient healthcare delivery solutions for the United States of America. Within the first 24 months of its initiation, the IU-CHIIS successfully scaled up an evidence-based collaborative care model for people with dementia and/or depression, successfully expanded the Accountable Care Unit model positively impacting the efficiency and quality of care, created the first Certificate in Innovation and Implementation Science in the US and secured funding from National Institutes of Health to investigate innovations in dementia care. This article summarizes the establishment of the IU-CHIIS, its impact and outcomes and the lessons learned during the journey. PMID:26028451

  1. A review of wireless-photonic systems: Design methodologies and topologies, constraints, challenges, and innovations in electronics and photonics

    NASA Astrophysics Data System (ADS)

    Farsaei, Ahmadreza; Wang, Yun; Molavi, Reza; Jayatilleka, Hasitha; Caverley, Michael; Beikahmadi, Mohammad; Masnadi Shirazi, Amir Hossein; Jaeger, Nicolas; Chrostowski, Lukas; Mirabbasi, Shahriar

    2016-08-01

    Photonic networks form the backbone for data communications. In particular, in current and future wireless communication systems, photonic networks are becoming increasingly popular for data distribution between the central office and the remote antenna units at base stations. As wireless-photonic systems become in increasing demand, low-cost implementation of such systems will be desirable. This paper describes how integrated photonics and electronics, on silicon, can be used to design such systems. Various building blocks of such silicon-photonics systems are reviewed. The emphasis is on a 60 GHz wireless system which could be suitable for the emerging 5th-generation (5G) cellular networks. The implementation discussed here uses digital baseband optical transmission as opposed to the radio-over-fibre approach.

  2. The innovative moments coding system and the assimilation of problematic experiences scale: a case study comparing two methods to track change in psychotherapy.

    PubMed

    Gonçalves, Miguel M; Gabalda, Isabel Caro; Ribeiro, António P; Pinheiro, PatrÍcia; Borges, Raquel; Sousa, Inês; Stiles, William B

    2014-01-01

    The Assimilation of Problematic Experiences Scale (APES) and the Innovative Moments Coding System were applied to transcripts of a successful case of linguistic therapy of evaluation independently by different research groups. Assimilation theory and research suggest that higher APES scores reflect therapeutic gains, with a level of approximately 4.0 separating good from poor outcome cases. The innovative moments (IMs) model suggests that IMs classified as reconceptualization and performing change occur mainly in good outcome cases, whereas action, reflection and protest occur in both good and poor outcome cases. Passages coded as reconceptualization and performing change were rare in this case, but 100% of them were rated at or above APES 4. By contrast, 63% passages coded as action, reflection or protest were rated below APES 4 (Chi-square = 28.62, p < .001). Implications for research are discussed. PMID:24099105

  3. Credit-Based Systems as Vehicles for Change in Universities and Colleges. Managing Innovation and Change in Universities and Colleges.

    ERIC Educational Resources Information Center

    Allen, Robert; Layer, Geoff

    This book discusses organizational, management and professional dimensions of change as credit-based systems are introduced in higher education institutions in the United Kingdom. Credit-based systems are taken to mean the flexible academic structures based around the parallel but interrelated concepts of credit and modularity. They are being…

  4. Providing the Basis for Innovative Improvements in Advanced LWR Reactor Passive Safety Systems Design: An Educational R&D Project

    SciTech Connect

    Brian G. Williams; Jim C. P. Liou; Hiral Kadakia; Bill Phoenix; Richard R. Schultz

    2007-02-27

    This project characterizes typical two-phase stratified flow conditions in advanced water reactor horizontal pipe sections, following activation of passive cooling systems. It provides (1) a means to educate nuclear engineering students regarding the importance of two-phase stratified flow in passive cooling systems to the safety of advanced reactor systems and (2) describes the experimental apparatus and process to measure key parameters essential to consider when designing passive emergency core cooling flow paths that may encounter this flow regime. Based on data collected, the state of analysis capabilities can be determined regarding stratified flow in advanced reactor systems and the best paths forward can be identified to ensure that the nuclear industry can properly characterize two-phase stratified flow in passive emergency core cooling systems.

  5. Rebels against the System: Leadership Agency and Curriculum Innovation in the Context of School Autonomy and Accountability in England

    ERIC Educational Resources Information Center

    Greany, Toby; Waterhouse, Joanne

    2016-01-01

    Purpose: The purpose of this paper is to describe and analyse the development of school autonomy, school leadership and curriculum innovation in England over the past 40 years. It provides a baseline picture for the wider international study on school autonomy and curriculum innovation. Design/methodology/approach: An initial literature review was…

  6. Status report - The Canadian Hospitals Injury Reporting and Prevention Program: a dynamic and innovative injury surveillance system.

    PubMed

    Crain, J; McFaull, S; Thompson, W; Skinner, R; Do, M T; Fréchette, M; Mukhi, S

    2016-06-01

    This status report on the Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP), an emergency department-based injury and poisoning surveillance system, describes the result of migrating from a centralized data entry and coding process to a decentralized process, the web-based eCHIRPP system, in 2011. This secure system is improving the CHIRPP's overall flexibility and timeliness, which are key attributes of an effective surveillance system. The integrated eCHIRPP platform enables near real-time data entry and access, has user-friendly data management and analysis tools, and allows for easier communication and connectivity across the CHIRPP network through an online collaboration centre. Current pilot testing of automated data monitoring and trend analysis tools-designed to monitor and flag incoming data according to predefined criteria (for example, a new consumer product)-is revealing eCHIRPP's potential for providing early warnings of new hazards, issues and trends. PMID:27284703

  7. Introducing vouchers for malaria prevention in Ghana and Tanzania: context and adoption of innovation in health systems.

    PubMed

    de Savigny, Don; Webster, Jayne; Agyepong, Irene Akua; Mwita, Alex; Bart-Plange, Constance; Baffoe-Wilmot, Aba; Koenker, Hannah; Kramer, Karen; Brown, Nick; Lengeler, Christian

    2012-10-01

    There are striking similarities in health system and other contexts between Tanzania and Ghana that are relevant to the scaling up of continuous delivery of insecticide treated nets (ITNs) for malaria prevention. However, specific contextual factors of relevance to ITN delivery have led implementation down very different pathways in the two countries. Both countries have made major efforts and investments to address this intervention through integrating consumer discount vouchers into the health system. Discount vouchers require arrangements among the public, private and non-governmental sectors and constitute a complex intervention in both health systems and business systems. In Tanzania, vouchers have moved beyond the planning agenda, had policies and programmes formulated, been sustained in implementation at national scale for many years and have become as of 2012 the main and only publicly supported continuous delivery system for ITNs. In Ghana national-scale implementation of vouchers never progressed beyond consideration on the agenda and piloting towards formulation of policy; and the approach was replaced by mass distribution campaigns with less dependency on or integration with the health system. By 2011, Ghana entered a phase with no publicly supported continuous delivery system for ITNs. To understand the different outcomes, we compared the voucher programme timelines, phases, processes and contexts in both countries in reference to the main health system building blocks (governance, human resources, financing, informatics, technologies and service delivery). Contextual factors which provided an enabling environment for the voucher scheme in Tanzania did not do so in Ghana. The voucher scheme was never seen as an appropriate national strategy, other delivery systems were not complementary and the private sector was under-developed. The extensive time devoted to engagement and consensus building among all stakeholders in Tanzania was an important and

  8. Enabling Innovation and Collaboration Across Geography and Culture: A Case Study of NASA's Systems Engineering Community of Practice

    NASA Technical Reports Server (NTRS)

    Topousis, Daria E.; Murphy, Keri; Robinson, Greg

    2008-01-01

    In 2004, NASA faced major knowledge sharing challenges due to geographically isolated field centers that inhibited personnel from sharing experiences and ideas. Mission failures and new directions for the agency demanded better collaborative tools. In addition, with the push to send astronauts back to the moon and to Mars, NASA recognized that systems engineering would have to improve across the agency. Of the ten field centers, seven had not built a spacecraft in over 30 years, and had lost systems engineering expertise. The Systems Engineering Community of Practice came together to capture the knowledge of its members using the suite of collaborative tools provided by the NASA Engineering Network (NEN.) The NEN provided a secure collaboration space for over 60 practitioners across the agency to assemble and review a NASA systems engineering handbook. Once the handbook was complete, they used the open community area to disseminate it. This case study explores both the technology and the social networking that made the community possible, describes technological approaches that facilitated rapid setup and low maintenance, provides best practices that other organizations could adopt, and discusses the vision for how this community will continue to collaborate across the field centers to benefit the agency as it continues exploring the solar system.

  9. Pipe Crawler{reg_sign} internal piping characterization system - deactivation and decommissioning focus area. Innovative Technology Summary Report

    SciTech Connect

    1998-02-01

    Pipe Crawler{reg_sign} is a pipe surveying system for performing radiological characterization and/or free release surveys of piping systems. The technology employs a family of manually advanced, wheeled platforms, or crawlers, fitted with one or more arrays of thin Geiger Mueller (GM) detectors operated from an external power supply and data processing unit. Survey readings are taken in a step-wise fashion. A video camera and tape recording system are used for video surveys of pipe interiors prior to and during radiological surveys. Pipe Crawler{reg_sign} has potential advantages over the baseline and other technologies in areas of cost, durability, waste minimization, and intrusiveness. Advantages include potentially reduced cost, potential reuse of the pipe system, reduced waste volume, and the ability to manage pipes in place with minimal disturbance to facility operations. Advantages over competing technologies include potentially reduced costs and the ability to perform beta-gamma surveys that are capable of passing regulatory scrutiny for free release of piping systems.

  10. Development of an innovative decentralized treatment system for the reclamation and reuse of strong wastewater from rural community: Effects of elevated CO2 concentrations.

    PubMed

    Chen, Xiaochen; Fukushi, Kensuke

    2016-09-15

    In a previous study, a soil-plant-based natural treatment system was successfully developed for post-treatment of anaerobically digested strong wastewater full of potential nutrients (nitrogen, phosphorus, and potassium). For upgraded performance, an innovative decentralized treatment system was further developed, in which an anaerobic digestion stage and a natural treatment system stage are placed within a greenhouse. This allows the CO2 generated by the processing of wastewater and biogas consumption to be sequestrated within the greenhouse for elevating its concentration level and potentially enhance nutrient removal and recovery from the applied wastewater. To investigate the feasibility of the system, a bench-scale experiment was conducted using CO2 chambers. Valuable Kentucky bluegrass was planted in two soil types (red ball earth and black soil) at three CO2 concentrations (340 ppm, 900 ppm, and 1400 ppm). The results confirmed the positive effects of elevated CO2 concentration on the biomass production and turf quality of Kentucky bluegrass as well as the resulting higher nutrient recovery efficiencies. More importantly, it was demonstrated that the elevated CO2 concentration significantly stimulated the soil nitrifying microorganisms and thus improved the nitrogen removal efficiency (a critical issue in ecological wastewater treatment). A CO2 concentration of 1400 ppm is therefore recommended for use in the system. The mechanism underlying this phenomenon was shown to be an indirect effect, in which the higher CO2 concentration first positively influenced growing plants, which then stimulated the soil nitrifier communities. The effects of soil type (a design parameter) and hydraulic and nutrient loading rates (an operational parameter) on system performance were also examined. The results favored black soil for system establishment. Based on the findings of this study, our proposed system is thought to have the potential to be scaled up and adopted by

  11. The Health Innovations Scholars Program: A Model for Accelerating Preclinical Medical Students' Mastery of Skills for Leading Improvement of Clinical Systems.

    PubMed

    Sweigart, Joseph R; Tad-Y, Darlene; Pierce, Read; Wagner, Emilie; Glasheen, Jeffrey J

    2016-07-01

    Dramatic changes in health care require physician leadership. Efforts to instill necessary skills often occur late in training. The Heath Innovations Scholars Program (HISP) provided preclinical medical students with experiential learning focused on process improvement. Students led initiatives to improve the discharge process for stroke patients. All students completed an aptitude survey and Quality Improvement Knowledge Assessment Test (QIKAT) before and after the program. Significant improvements occurred across subject areas of leadership (18.4%, P < .001), quality and safety (14.7%, P < .001), and health care systems operations (21.2%, P < .008), and in the domains of knowledge (25.9%, P < .001) and skills (25.2%, P < .001). Average cumulative QIKAT results improved significantly (8.33 to 9.83, P = .04). Three of 4 recommended interventions were implemented. Furthermore, students engaged in other process improvement work on return to their home institutions. The HISP successfully advanced preclinical medical students' ability to lead clinical systems improvement.

  12. Innovative Techniques of Multiphase Flow in Pipeline System for Oil-Gas Gathering and Transportation with Energy-Saving and Emission-Reduction

    NASA Astrophysics Data System (ADS)

    Bai, Bofeng; Guo, Liejin; Zhang, Shaojun; Zhang, Ximin; Gu, Hanyang

    2010-03-01

    Multiphase flow measurement, desanding, dehumidification and heat furnace are critical techniques for the oil and gas gathering and transportation, which influnce intensively the energy-saving and emission-reduction in the petroleum industry. Some innovative techniques were developed for the first time by the present research team, including an online recognation instrument of multiphase flow regime, a water fraction instrument for multuphase flow, a coiled tube desanding separator with low pressure loss and high efficiency, a supersonic swirling natural gas dehumifier, and a vacuum phase-change boiler. With an integration of the above techniques, a new oil gas gathering and transpotation system was proposed, which reduced the establishment of one metering station and several transfer stations compared with the tranditional system. The oil and gas mixture transpotation in single pipes was realized. The improved techniques were applied in the oilfields in China and promoted the productivity of the oilfields by low energy consumption, low emissions, high efficiency and great security.

  13. Innovative sponge-based moving bed-osmotic membrane bioreactor hybrid system using a new class of draw solution for municipal wastewater treatment.

    PubMed

    Nguyen, Nguyen Cong; Chen, Shiao-Shing; Nguyen, Hau Thi; Ray, Saikat Sinha; Ngo, Huu Hao; Guo, Wenshan; Lin, Po-Hsun

    2016-03-15

    For the first time, an innovative concept of combining sponge-based moving bed (SMB) and an osmotic membrane bioreactor (OsMBR), known as the SMB-OsMBR hybrid system, were investigated using Triton X-114 surfactant coupled with MgCl2 salt as the draw solution. Compared to traditional activated sludge OsMBR, the SMB-OsMBR system was able to remove more nutrients due to the thick-biofilm layer on sponge carriers. Subsequently less membrane fouling was observed during the wastewater treatment process. A water flux of 11.38 L/(m(2) h) and a negligible reverse salt flux were documented when deionized water served as the feed solution and a mixture of 1.5 M MgCl2 and 1.5 mM Triton X-114 was used as the draw solution. The SMB-OsMBR hybrid system indicated that a stable water flux of 10.5 L/(m(2) h) and low salt accumulation were achieved in a 90-day operation. Moreover, the nutrient removal efficiency of the proposed system was close to 100%, confirming the effectiveness of simultaneous nitrification and denitrification in the biofilm layer on sponge carriers. The overall performance of the SMB-OsMBR hybrid system using MgCl2 coupled with Triton X-114 as the draw solution demonstrates its potential application in wastewater treatment.

  14. Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity?

    PubMed

    Goldman, Alyssa W; Burmeister, Yvonne; Cesnulevicius, Konstantin; Herbert, Martha; Kane, Mary; Lescheid, David; McCaffrey, Timothy; Schultz, Myron; Seilheimer, Bernd; Smit, Alta; St Laurent, Georges; Berman, Brian

    2015-01-01

    Bioregulatory systems medicine (BrSM) is a paradigm that aims to advance current medical practices. The basic scientific and clinical tenets of this approach embrace an interconnected picture of human health, supported largely by recent advances in systems biology and genomics, and focus on the implications of multi-scale interconnectivity for improving therapeutic approaches to disease. This article introduces the formal incorporation of these scientific and clinical elements into a cohesive theoretical model of the BrSM approach. The authors review this integrated body of knowledge and discuss how the emergent conceptual model offers the medical field a new avenue for extending the armamentarium of current treatment and healthcare, with the ultimate goal of improving population health.

  15. Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity?

    PubMed Central

    Goldman, Alyssa W.; Burmeister, Yvonne; Cesnulevicius, Konstantin; Herbert, Martha; Kane, Mary; Lescheid, David; McCaffrey, Timothy; Schultz, Myron; Seilheimer, Bernd; Smit, Alta; St. Laurent, Georges; Berman, Brian

    2015-01-01

    Bioregulatory systems medicine (BrSM) is a paradigm that aims to advance current medical practices. The basic scientific and clinical tenets of this approach embrace an interconnected picture of human health, supported largely by recent advances in systems biology and genomics, and focus on the implications of multi-scale interconnectivity for improving therapeutic approaches to disease. This article introduces the formal incorporation of these scientific and clinical elements into a cohesive theoretical model of the BrSM approach. The authors review this integrated body of knowledge and discuss how the emergent conceptual model offers the medical field a new avenue for extending the armamentarium of current treatment and healthcare, with the ultimate goal of improving population health. PMID:26347656

  16. Optimum design and global analysis of flexible jumper for an innovative subsurface production system in ultra-deep water

    NASA Astrophysics Data System (ADS)

    Huang, Yi; Zhen, Xing-wei; Zhang, Qi; Wang, Wen-hua

    2014-04-01

    The study focuses on the flexible jumper issue of Subsurface Tension Leg Production (STLP) system concept, which is considered as a competing alternative system to support well completion devices and rigid risers in ultra-deep water for offshore petroleum production. The paper presents analytical and numerical approaches for the optimum design and global analysis of the flexible jumper. Criteria using catenary concept are developed to define the critical length for optimum design. Based on the criteria, detailed hydrodynamic analyses including quasi-static analysis, modal analysis, and dynamic analysis are performed. Modal analysis with respect to the quasi-static analysis shows that the existence of resonant modes requires special consideration. The results of dynamic analysis confirm the effectiveness of the de-coupled effect from the jumper on STLP system. The approaches developed in the study also have wide application prospect in reference to the optimum design and analysis of any Hybrid Riser (HR) concept.

  17. Public health imperative of the 21st century: innovations in palliative care systems, services, and supports to improve health and well-being of older americans.

    PubMed

    Morrissey, Mary Beth; Herr, Keela; Levine, Carol

    2015-04-01

    A primary aim of federal aging and health policy must be promoting innovations in palliative care systems, services, and supports that improve the experience of growing old in America. Older adults must contend today with increasing burden over the life course often as the result of life-limiting chronic pain and chronic illnesses as well as social and economic factors beyond their control. These burdens are frequently shared with unpaid family caregivers who provide significant uncompensated medical care and social support to their loved ones. Enjoyment of the highest attainable standard of physical and mental health, recognized as a fundamental human right under international law, remains a goal for all older adults and encompasses the right to palliative care. For many older Americans, especially vulnerable subgroups who face health and pain disparities, however, this goal remains elusive. A public health strategy for implementing palliative care policy interventions will help to build age-friendly environments, assure the availability and accessibility of palliative systems of care, essential medicines, and an adequate generalist-level workforce, and sustain diffusion of innovation across all levels of health and social provision. The 2015 White House Conference on Aging must make these realignments a policy priority in order to foster social and economic development for all older Americans.

  18. Public health imperative of the 21st century: innovations in palliative care systems, services, and supports to improve health and well-being of older americans.

    PubMed

    Morrissey, Mary Beth; Herr, Keela; Levine, Carol

    2015-04-01

    A primary aim of federal aging and health policy must be promoting innovations in palliative care systems, services, and supports that improve the experience of growing old in America. Older adults must contend today with increasing burden over the life course often as the result of life-limiting chronic pain and chronic illnesses as well as social and economic factors beyond their control. These burdens are frequently shared with unpaid family caregivers who provide significant uncompensated medical care and social support to their loved ones. Enjoyment of the highest attainable standard of physical and mental health, recognized as a fundamental human right under international law, remains a goal for all older adults and encompasses the right to palliative care. For many older Americans, especially vulnerable subgroups who face health and pain disparities, however, this goal remains elusive. A public health strategy for implementing palliative care policy interventions will help to build age-friendly environments, assure the availability and accessibility of palliative systems of care, essential medicines, and an adequate generalist-level workforce, and sustain diffusion of innovation across all levels of health and social provision. The 2015 White House Conference on Aging must make these realignments a policy priority in order to foster social and economic development for all older Americans. PMID:26035600

  19. Multilevel dynamic systems affecting introduction of HIV/STI prevention innovations among Chinese women in sex work establishments.

    PubMed

    Weeks, Margaret R; Li, Jianghong; Liao, Susu; Zhang, Qingning; Dunn, Jennifer; Wang, Yanhong; Jiang, Jingmei

    2013-10-01

    Social and public health scientists are increasingly interested in applying system dynamics theory to improve understanding and to harness the forces of change within complex, multilevel systems that affect community intervention implementation, effects, and sustainability. Building a system dynamics model based on ethnographic case study has the advantage of using empirically documented contextual factors and processes of change in a real-world and real-time setting that can then be tested in the same and other settings. System dynamics modeling offers great promise for addressing persistent problems like HIV and other sexually transmitted epidemics, particularly in complex rapidly developing countries such as China. We generated a system dynamics model of a multilevel intervention we conducted to promote female condoms for HIV/sexually transmitted infection (STI) prevention among Chinese women in sex work establishments. The model reflects factors and forces affecting the study's intervention, implementation, and effects. To build this conceptual model, we drew on our experiences and findings from this intensive, longitudinal mixed-ethnographic and quantitative four-town comparative case study (2007-2012) of the sex work establishments, the intervention conducted in them, and factors likely to explain variation in process and outcomes in the four towns. Multiple feedback loops in the sex work establishments, women's social networks, and the health organization responsible for implementing HIV/STI interventions in each town and at the town level directly or indirectly influenced the female condom intervention. We present the conceptual system dynamics model and discuss how further testing in this and other settings can inform future community interventions to reduce HIV and STIs. PMID:24084394

  20. Mining Survey System (MSS) - innovative solution in Polish mines. (Polish Title: Mobilna Platforma Gurnicza (MPG) - nowatorskim rozwilazaniem w polskich kopalniach)

    NASA Astrophysics Data System (ADS)

    Adamek, A.

    2015-12-01

    Mobile laser scanning technology is developing rapidly also in mining. For several years research and tests are conducted on the use of that type of measurement in the inventory of the mine shafts. The company SKALA 3D in the project 1.4 POIG by PARP undertook to create Mobile automatic steering system of spatial geometry measurements mine shafts using laser scanning technology. Its main advantage is a faithful reflection of the object being measured in just a few hours. It is based on the data flowing from laser scanners and precision inertial unit. The main problem of the research was to determine the trajectory of the passing Mobile Platforms Mining (MPG) in the shaft as accurately as possible. Unable to receive signals from satellites in the pipe shaft prevented the use of solutions known for measuring terrestrial mobile systems. The company SKALA 3D has developed a methodology for determine the trajectory of the system, based on geometrical data coming from laser scanners and readings of accelerometers and gyroscopes of inertial unit. To improve the quality and accuracy of measurements MPG is also equipped with a set of anti-vibration parts prevent the transmission of vibrations ascending while cage is moving in the shaft on the measuring system. The whole forms a calibrated system, which in a short time is able to provide spatial measurement data from the measuring shaft. The accuracy of 2-3 mm in a single measurement horizon and a few centimeters determine the position of a point on the thousandth meter below ground make the system very accurate. During the project there have been numerous research problems, including the need to define the physical references, drift of IMU whether harsh weather conditions in the shaft. However, the company SKALA 3D solved these problems and making MPG unique in the world.

  1. Multilevel dynamic systems affecting introduction of HIV/STI prevention innovations among Chinese women in sex work establishments.

    PubMed

    Weeks, Margaret R; Li, Jianghong; Liao, Susu; Zhang, Qingning; Dunn, Jennifer; Wang, Yanhong; Jiang, Jingmei

    2013-10-01

    Social and public health scientists are increasingly interested in applying system dynamics theory to improve understanding and to harness the forces of change within complex, multilevel systems that affect community intervention implementation, effects, and sustainability. Building a system dynamics model based on ethnographic case study has the advantage of using empirically documented contextual factors and processes of change in a real-world and real-time setting that can then be tested in the same and other settings. System dynamics modeling offers great promise for addressing persistent problems like HIV and other sexually transmitted epidemics, particularly in complex rapidly developing countries such as China. We generated a system dynamics model of a multilevel intervention we conducted to promote female condoms for HIV/sexually transmitted infection (STI) prevention among Chinese women in sex work establishments. The model reflects factors and forces affecting the study's intervention, implementation, and effects. To build this conceptual model, we drew on our experiences and findings from this intensive, longitudinal mixed-ethnographic and quantitative four-town comparative case study (2007-2012) of the sex work establishments, the intervention conducted in them, and factors likely to explain variation in process and outcomes in the four towns. Multiple feedback loops in the sex work establishments, women's social networks, and the health organization responsible for implementing HIV/STI interventions in each town and at the town level directly or indirectly influenced the female condom intervention. We present the conceptual system dynamics model and discuss how further testing in this and other settings can inform future community interventions to reduce HIV and STIs.

  2. An innovation approach to exploration and exploitation drilling; The slim-hole high-speed drilling system

    SciTech Connect

    Walker, S.H. ); Millheim, K.K. )

    1990-09-01

    This paper reports how slim-hole continuous-core drilling and on-site near-real-time core analysis offer a new dimension for oil and gas exploration, especially in remote, difficult, and environmentally sensitive areas. Technologies borrowed from the mining and oilfield drilling industries coupled with newly developed technologies were used to create a new drilling and evaluation system designed around continuous coring, slim holes, and inverse logging--i.e., the logging of the actual rock as it is retrieved. This new system could cause a paradigm shift in exploration.

  3. Innovative production of bio-cellulose using a cell-free system derived from a single cell line.

    PubMed

    Ullah, Muhammad Wajid; Ul-Islam, Mazhar; Khan, Shaukat; Kim, Yeji; Park, Joong Kon

    2015-11-01

    The current study was intended to produce bio-cellulose through a cell-free system developed by disrupting Gluconacetobacter hansenii PJK through bead-beating. Microscopic analysis indicated the complete disruption of cells (2.6 × 10(7) cells/mL) in 20 min that added 95.12 μg/mL protein, 1.63 mM ATP, and 1.11 mM NADH into the medium. A liquid chromatography mass spectrometry/mass spectrometry linear trap quadrupole (LC-MS/MS LTQ) Orbitrap analysis of cell-lysate confirmed the presence of all key enzymes for bio-cellulose synthesis. Under static conditions at 30 °C, microbial and cell-free systems produced 3.78 and 3.72 g/L cellulose, corresponding to 39.62 and 57.68% yield, respectively after 15 days. The improved yield based on consumed glucose indicated the superiority of cell-free system. Based on current findings and literature, we hypothesized a synthetic pathway for bio-cellulose synthesis in the cell-free system. This approach can overcome some limitations of cellulose-producing cells and offers a wider scope for synthesizing cellulose composites with bactericidal elements through in situ synthesizing approaches.

  4. From Innovative Programs to Systemic Education Reform: Lesson from Five Communities. The Final Report of the Benchmark Communities Initiative.

    ERIC Educational Resources Information Center

    DeSalvatore, Larry; Goldberger, Susan; Steinberg, Adria

    This document presents the lessons of Jobs for the Future's Benchmark Communities Initiative (BCI), a 5-year systemic educational reform initiative launched in 1994 in five communities. Before joining the BCI, the five Benchmark communities had each begun a school-to-career effort. Five key findings from the BCI are outlined: (1) students engaged…

  5. T and D-Bench--Innovative Combined Support for Education and Research in Computer Architecture and Embedded Systems

    ERIC Educational Resources Information Center

    Soares, S. N.; Wagner, F. R.

    2011-01-01

    Teaching and Design Workbench (T&D-Bench) is a framework aimed at education and research in the areas of computer architecture and embedded systems. It includes a set of features not found in other educational environments. This set of features is the result of an original combination of design requirements for T&D-Bench: that the framework should…

  6. Anticipating Innovation in Teacher Evaluation Systems: Lessons for Researchers and Policymakers. Teacher Quality 2.0. Special Report 4

    ERIC Educational Resources Information Center

    Hansen, Michael

    2013-01-01

    The growing prominence of value-added models for measuring teacher effectiveness has prompted a recent surge in policies that consider students' classroom performance part of a teacher's evaluation. Yet, in light of the criticism and limitations of the current models, whether and how evaluation systems will adapt over time is unclear. This paper…

  7. Innovative production of bio-cellulose using a cell-free system derived from a single cell line.

    PubMed

    Ullah, Muhammad Wajid; Ul-Islam, Mazhar; Khan, Shaukat; Kim, Yeji; Park, Joong Kon

    2015-11-01

    The current study was intended to produce bio-cellulose through a cell-free system developed by disrupting Gluconacetobacter hansenii PJK through bead-beating. Microscopic analysis indicated the complete disruption of cells (2.6 × 10(7) cells/mL) in 20 min that added 95.12 μg/mL protein, 1.63 mM ATP, and 1.11 mM NADH into the medium. A liquid chromatography mass spectrometry/mass spectrometry linear trap quadrupole (LC-MS/MS LTQ) Orbitrap analysis of cell-lysate confirmed the presence of all key enzymes for bio-cellulose synthesis. Under static conditions at 30 °C, microbial and cell-free systems produced 3.78 and 3.72 g/L cellulose, corresponding to 39.62 and 57.68% yield, respectively after 15 days. The improved yield based on consumed glucose indicated the superiority of cell-free system. Based on current findings and literature, we hypothesized a synthetic pathway for bio-cellulose synthesis in the cell-free system. This approach can overcome some limitations of cellulose-producing cells and offers a wider scope for synthesizing cellulose composites with bactericidal elements through in situ synthesizing approaches. PMID:26256351

  8. Environmental Media Systems: Innovations at the U.S. Environmental Protection Agency's National Exposure Research Laboratory

    ERIC Educational Resources Information Center

    Costelloe-Kuehn, Brandon

    2012-01-01

    This multi-sited ethnography analyzes challenges and opportunities in the design and development of digital media systems in the Office of Research and Development (ORD) at the United States Environmental Protection Agency (EPA). Drawing heavily from interviews conducted over the course of three years, primarily with scientists at the ORD's…

  9. Innovative Delivery Systems to Meet School Staffing Needs. Proceedings of the Annual Meeting of the National Association of State Directors of Teacher Education and Certification (53rd, Williamsburg, VA, June 23-25, 1981).

    ERIC Educational Resources Information Center

    Mackey, Charles C., Jr., Ed.

    Presentations delivered at the 1981 annual meeting of the National Association of State Directors of Teacher Education and Certification are presented in this publication. The papers consist of: (1) an edited transcript of a discussion on "Innovative Delivery Systems" (W. Robert Houston, Dwight Allen, and Fred Wood); (2) "Delivery Systems in a…

  10. Farms and Learning Partnerships in Farming Systems Projects: A Response to the Challenges of Complexity in Agricultural Innovation

    ERIC Educational Resources Information Center

    Crawford, Anne; Nettle, Ruth; Paine, Mark; Kabore, Carolyn

    2007-01-01

    Managing the competing interests of productivity growth, environmental concerns, landscape change and societal expectations presents challenges for agricultural industries. Innovation projects supporting knowledge development to address these challenges often involve partnerships with commercial farms, a methodology which promises much but has…

  11. Innovation in Distance Education Learning Systems: The Case of the National Correspondence Institute of Tanzania, 1972-2002

    ERIC Educational Resources Information Center

    Mutanyatta, J. N. S.

    2008-01-01

    The paper attempts to provide relevant data on the achievements, albeit quantitatively, of the National Correspondence Institute of Tanzania over the past 30 years as a case study in distance education innovation. The case-study data reveal reasons for the near collapse of the distance education programme during the 1990s, and the renewed policy…

  12. Revitalizing the patent system to incentivize pharmaceutical innovation: the potential of claims with means-plus-function clauses.

    PubMed

    Tang, Wanli Lily

    2013-02-01

    The pharmaceutical industry relies on innovation. However, many innovative firms are cutting their research and development investments and seeing their new product pipelines dry up, due in part to a lack of sufficient patent protection. This Note identifies two major factors that have caused this inadequacy in patent protection. First, pharmaceutical patents are challenged early and often by generic manufacturers, as encouraged by the 1984 Hatch-Waxman Act. Second, the scope of pharmaceutical-patents is sometimes unduly restrained due to limited application of the doctrine of equivalents. Consequently, pharmaceutical patents, especially drug-product patents, are easily designed around and cannot offer the protection necessary for innovative firms to recoup their developmental costs. This Note argues for a wider application of means-plus-function clauses in pharmaceutical patents as a potential cure for this problem. Means-plus-function claims, although authorized by Congress in the 1952 Patent Act, have not been explored much in the pharmaceutical context. This Note argues that this claiming strategy is not only appropriate but also particularly effective for pharmaceutical patents. Means-plus-function claims would give drug-product patents adequate scope even with the limited use of the doctrine of equivalents and thus would provide the protection necessary for innovative firms to withstand frequent attacks by generic manufacturers. Finally, this Note examines issues anticipated with applying means-plus-function claims to pharmaceutical patents and proposes possible solutions.

  13. Towards a Better Conceptual Framework for Innovation Processes in Agriculture and Rural Development: From Linear Models to Systemic Approaches

    ERIC Educational Resources Information Center

    Knickel, Karlheinz; Brunori, Gianluca; Rand, Sigrid; Proost, Jet

    2009-01-01

    The role of farming previously dedicated mainly to food production changed with an increasing recognition of the multifunctionality of agriculture and rural areas. It seems obvious to expect that farmers and rural actors adapt themselves to these new conditions, which are innovative and redefine their job. In many regions farmers can increase…

  14. Exploring the interpersonal-, organization-, and system-level factors that influence the implementation and use of an innovation-synoptic reporting-in cancer care

    PubMed Central

    2012-01-01

    Background The dominant method of reporting findings from diagnostic and surgical procedures is the narrative report. In cancer care, this report inconsistently provides the information required to understand the cancer and make informed patient care decisions. Another method of reporting, the synoptic report, captures specific data items in a structured manner and contains only items critical for patient care. Research demonstrates that synoptic reports vastly improve the quality of reporting. However, synoptic reporting represents a complex innovation in cancer care, with implementation and use requiring fundamental shifts in physician behaviour and practice, and support from the organization and larger system. The objective of this study is to examine the key interpersonal, organizational, and system-level factors that influence the implementation and use of synoptic reporting in cancer care. Methods This study involves three initiatives in Nova Scotia, Canada, that have implemented synoptic reporting within their departments/programs. Case study methodology will be used to study these initiatives (the cases) in-depth, explore which factors were barriers or facilitators of implementation and use, examine relationships amongst factors, and uncover which factors appear to be similar and distinct across cases. The cases were selected as they converge and differ with respect to factors that are likely to influence the implementation and use of an innovation in practice. Data will be collected through in-depth interviews, document analysis, observation of training sessions, and examination/use of the synoptic reporting tools. An audit will be performed to determine/quantify use. Analysis will involve production of a case record/history for each case, in-depth analysis of each case, and cross-case analysis, where findings will be compared and contrasted across cases to develop theoretically informed, generalisable knowledge that can be applied to other settings

  15. Innovations and enhancements in neutronic analysis of the Big-10 university research and training reactors based on the AGENT code system

    SciTech Connect

    Hursin, M.; Shanjie, X.; Burns, A.; Hopkins, J.; Satvat, N.; Gert, G.; Tsoukalas, L. H.; Jevremovic, T.

    2006-07-01

    Introduction. This paper summarizes salient aspects of the 'virtual' reactor system developed at Purdue Univ. emphasizing efficient neutronic modeling through AGENT (Arbitrary Geometry Neutron Transport) a deterministic neutron transport code. DOE's Big-10 Innovations in Nuclear Infrastructure and Education (INIE) Consortium was launched in 2002 to enhance scholarship activities pertaining to university research and training reactors (URTRs). Existing and next generation URTRs are powerful campus tools for nuclear engineering as well as a number of disciplines that include, but are not limited to, medicine, biology, material science, and food science. Advancing new computational environments for the analysis and configuration of URTRs is an important Big-10 INIE aim. Specifically, Big-10 INIE has pursued development of a 'virtual' reactor, an advanced computational environment to serve as a platform on which to build operations, utilization (research and education), and systemic analysis of URTRs physics. The 'virtual' reactor computational system will integrate computational tools addressing the URTR core and near core physics (transport, dynamics, fuel management and fuel configuration); thermal-hydraulics; beam line, in-core and near-core experiments; instrumentation and controls; confinement/containment and security issues. Such integrated computational environment does not currently exist. The 'virtual' reactor is designed to allow researchers and educators to configure and analyze their systems to optimize experiments, fuel locations for flux shaping, as well as detector selection and configuration. (authors)

  16. System Documentation Manual.

    ERIC Educational Resources Information Center

    Semmel, Melvyn I.; Olson, Jerry

    The document is a system documentation manual of the Computer-Assisted Teacher Training System (CATTS) developed by the Center for Innovation in Teaching the Handicapped (Indiana University). CATTS is characterized as a system capable of providing continuous, instantaneous, and/or delayed feedback of relevant teacher-student interaction data to a…

  17. [Curriculum design of the Master's in Public Health program via the inservice education system. The Working Group of the Innovation Program in Health Systems and Professional Training].

    PubMed

    1995-01-01

    This article presents the curriculum design process experience of the School of Public Health of Mexico's In-Service Master of Public Health Program, offered through the distance education model. The Program was created as a response to the Mexican health system's human resources training needs, with the purpose of contributing to the health services decentralization process, the strengthening of managerial skills of local health district managers, and to the professionalization of public health. The Program's design and development are based on a distance education system as an alternative to the traditional training models. The distance education model offers the possibility to train human resources on their job, to link permanently theory and practice, and to improve, in the short-term, the professional performance of students. The curriculum design process included the analysis of the student's training needs based on their professional profile, the type of plan of study that could take into account those training needs, and of the advisers and tutor's required profile, educational background, and job experience. The different disciplines were grouped around the knowledge objects, and not around independent courses. The health planning process was taken as a central axis and conductive line for integrating the thematic contents. The Master's plan of study was conformed by four stages: health diagnosis, formulation of the organized social response, implementation, and evaluation.

  18. The Vienna comparative cognition technology (VCCT): an innovative operant conditioning system for various species and experimental procedures.

    PubMed

    Steurer, Michael Morten; Aust, Ulrike; Huber, Ludwig

    2012-12-01

    This article describes a laboratory system for running learning experiments in operant chambers with various species. It is based on a modern version of a classical learning chamber for operant conditioning, the so-called "Skinner box". Rather than constituting a stand-alone unit, as is usually the case, it is an integrated part of a comprehensive technical solution, thereby eliminating a number of practical problems that are frequently encountered in research on animal learning and behavior. The Vienna comparative cognition technology combines modern computer, stimulus presentation, and reinforcement technology with flexibility and user-friendliness, which allows for efficient, widely automatized across-species experimentation, and thus makes the system appropriate for use in a broad range of learning tasks.

  19. Cross-institutional Flood Forecasting in Regional Water Systems;Innovative application of Delft-FEWS in The Netherlands

    NASA Astrophysics Data System (ADS)

    van Heeringen, Klaas-Jan; Douben, Klaas-Jan; van de Wouw, Mark; IJpelaar, Ruben; van Loenen, Arnejan

    2015-04-01

    The regional water system in the North-Brabant province in The Netherlands is (operationally) managed by four different Water Authorities: Rijkswaterstaat Southern-Netherlands, and the three Regional Water Authorities (RWA's) Aa & Maas, De Dommel and Brabantse Delta. The water systems basically consist of mid-sized (navigable) canals, semi-natural brook valleys in mildly sloping sandy soils, and man-made watercourses in clayey polder areas. The management areas of the De Dommel and Brabantse Delta RWA's are bordering Belgium over a total length of approx. 185 km, and are prone to transboundary flood flows. The current project 'Dynamic Water Management' intends to improve the mutual cooperation and communication between the RWA's and Rijkswaterstaat during periods of both high and low water stages. The project deals with governance issues such as water agreements and water systems analyses. A powerful product of the project is a DSS for flood forecasting ('DSS Brabant'). One of the main benefits of cooperation between the RWA's and Rijkswaterstaat is to enable assistance during peak flows and flood events and to try to optimise operational water systems management by deploying drainage and storage facilities by using the connecting (navigable) canals. A set of hydraulic structures like pumps, weirs and sluices facilitate the control and routing of the water flows. Especially during peak flow and flood events, these canals allow to deviate excess flow to neighbours who suffer less from flooding. During regular conditions the water systems are fully independent, but during floods connections are made by using the canal system. The heart of DSS Brabant consists of a Delft-FEWS application, containing several RTC (1st) and hydrodynamic Sobek (2nd order) models FEWS is receiving a variety of data on hourly or six-hourly basis, consisting of measured and forecasted meteorological input (radar-precipitation/HIRLAM, evaporation and wind), water levels and discharges at

  20. EBP2R - an innovative enhanced biological nutrient recovery activated sludge system to produce growth medium for green microalgae cultivation.

    PubMed

    Valverde-Pérez, Borja; Ramin, Elham; Smets, Barth F; Plósz, Benedek Gy

    2015-01-01

    Current research considers wastewater as a source of energy, nutrients and water and not just a source of pollution. So far, mainly energy intensive physical and chemical unit processes have been developed to recover some of these resources, and less energy and resource demanding alternatives are needed. Here, we present a modified enhanced biological phosphorus removal and recovery system (referred to as EBP2R) that can produce optimal culture media for downstream micro-algal growth in terms of N and P content. Phosphorus is recovered as a P-stream by diversion of some of the effluent from the upstream anaerobic reactor. By operating the process at comparably low solids retention times (SRT), the nitrogen content of wastewater is retained as free and saline ammonia, the preferred form of nitrogen for most micro-algae. Scenario simulations were carried out to assess the capacity of the EBP2R system to produce nutrient rich organic-carbon depleted algal cultivation media of target composition. Via SRT control, the quality of the constructed cultivation media can be optimized to support a wide range of green micro-algal growth requirements. Up to 75% of the influent phosphorus can be recovered, by diverting 30% of the influent flow as a P-stream at an SRT of 5 days. Through global sensitivity analysis we find that the effluent N-to-P ratio and the P recovered are mainly dependent on the influent quality rather than on biokinetics or stoichiometry. Further research is needed to demonstrate that the system performance predicted through the model-based design can be achieved in reality. PMID:25480432

  1. An Innovative Optical Sensor for the Online Monitoring and Control of Biomass Concentration in a Membrane Bioreactor System for Lactic Acid Production

    PubMed Central

    Fan, Rong; Ebrahimi, Mehrdad; Quitmann, Hendrich; Aden, Matthias; Czermak, Peter

    2016-01-01

    Accurate real-time process control is necessary to increase process efficiency, and optical sensors offer a competitive solution because they provide diverse system information in a noninvasive manner. We used an innovative scattered light sensor for the online monitoring of biomass during lactic acid production in a membrane bioreactor system because biomass determines productivity in this type of process. The upper limit of the measurement range in fermentation broth containing Bacillus coagulans was ~2.2 g·L−1. The specific cell growth rate (µ) during the exponential phase was calculated using data representing the linear range (cell density ≤ 0.5 g·L−1). The results were consistently and reproducibly more accurate than offline measurements of optical density and cell dry weight, because more data were gathered in real-time over a shorter duration. Furthermore, µmax was measured under different filtration conditions (transmembrane pressure 0.3–1.2 bar, crossflow velocity 0.5–1.5 m·s−1), showing that energy input had no significant impact on cell growth. Cell density was monitored using the sensor during filtration and was maintained at a constant level by feeding with glucose according to the fermentation kinetics. Our novel sensor is therefore suitable for integration into control strategies for continuous fermentation in membrane bioreactor systems. PMID:27007380

  2. An Innovative Optical Sensor for the Online Monitoring and Control of Biomass Concentration in a Membrane Bioreactor System for Lactic Acid Production.

    PubMed

    Fan, Rong; Ebrahimi, Mehrdad; Quitmann, Hendrich; Aden, Matthias; Czermak, Peter

    2016-03-21

    Accurate real-time process control is necessary to increase process efficiency, and optical sensors offer a competitive solution because they provide diverse system information in a noninvasive manner. We used an innovative scattered light sensor for the online monitoring of biomass during lactic acid production in a membrane bioreactor system because biomass determines productivity in this type of process. The upper limit of the measurement range in fermentation broth containing Bacillus coagulans was ~2.2 g·L(-1). The specific cell growth rate (µ) during the exponential phase was calculated using data representing the linear range (cell density ≤ 0.5 g·L(-1)). The results were consistently and reproducibly more accurate than offline measurements of optical density and cell dry weight, because more data were gathered in real-time over a shorter duration. Furthermore, µ(max) was measured under different filtration conditions (transmembrane pressure 0.3-1.2 bar, crossflow velocity 0.5-1.5 m·s(-1)), showing that energy input had no significant impact on cell growth. Cell density was monitored using the sensor during filtration and was maintained at a constant level by feeding with glucose according to the fermentation kinetics. Our novel sensor is therefore suitable for integration into control strategies for continuous fermentation in membrane bioreactor systems.

  3. An Innovative Optical Sensor for the Online Monitoring and Control of Biomass Concentration in a Membrane Bioreactor System for Lactic Acid Production.

    PubMed

    Fan, Rong; Ebrahimi, Mehrdad; Quitmann, Hendrich; Aden, Matthias; Czermak, Peter

    2016-01-01

    Accurate real-time process control is necessary to increase process efficiency, and optical sensors offer a competitive solution because they provide diverse system information in a noninvasive manner. We used an innovative scattered light sensor for the online monitoring of biomass during lactic acid production in a membrane bioreactor system because biomass determines productivity in this type of process. The upper limit of the measurement range in fermentation broth containing Bacillus coagulans was ~2.2 g·L(-1). The specific cell growth rate (µ) during the exponential phase was calculated using data representing the linear range (cell density ≤ 0.5 g·L(-1)). The results were consistently and reproducibly more accurate than offline measurements of optical density and cell dry weight, because more data were gathered in real-time over a shorter duration. Furthermore, µ(max) was measured under different filtration conditions (transmembrane pressure 0.3-1.2 bar, crossflow velocity 0.5-1.5 m·s(-1)), showing that energy input had no significant impact on cell growth. Cell density was monitored using the sensor during filtration and was maintained at a constant level by feeding with glucose according to the fermentation kinetics. Our novel sensor is therefore suitable for integration into control strategies for continuous fermentation in membrane bioreactor systems. PMID:27007380

  4. In vivo assessment of the efficacy of an innovative face care system in subjects with mild acne vulgaris.

    PubMed

    Scherdin, U; Presto, S; Rippke, F; Nielsen, J; Strassner, M; Imadojemun, A; Gärtner, E; Herpens, A; Korting, H C; Bielfeldt, S

    2004-10-01

    The purpose of our studies was to verify efficacy and skin compatibility of a medical face care system containing 2% lactic acid (LA) as active ingredient in a specially designed vehicle (Follicle Targeting System) in adult subjects with mild acne vulgaris. The first study (46 patients) demonstrated superiority of 2% LA in comparison to 2% salicylic acid with respect to number of comedones and inflammatory lesions. The second study evaluated 90 patients receiving distinct combinations of face care products (Eucerin) Impure Skin, Hamburg, Germany), i.e. cleansing gel, facial tonic (2% LA) and cream gel (2% LA). All treatments were performed twice daily over a 12 weeks period. Lesion counts, cyanoacrylate biopsies and determination of quality of life by questionnaires were performed at different timepoints. A reduction of comedones by 56% corresponding to an 46% increase of quality of life index was demonstrated in patients applying cleansing gel, facial tonic and cream gel. For the first time we were able to show a significant improvement concerning the quality of life after using a new face care line. Especially adults with mild forms of acne may benefit from this effective skin care regimen. PMID:18492134

  5. The endocannabinoid system and Post Traumatic Stress Disorder (PTSD): From preclinical findings to innovative therapeutic approaches in clinical settings.

    PubMed

    Berardi, Andrea; Schelling, Gustav; Campolongo, Patrizia

    2016-09-01

    Post-Traumatic Stress Disorder (PTSD) is a psychiatric chronic disease developing in individuals after the experience of an intense and life-threatening traumatic event. The post-traumatic symptomatology encompasses alterations in memory processes, mood, anxiety and arousal. There is now consensus in considering the disease as an aberrant adaptation to traumatic stress. Pharmacological research, aimed at the discovery of new potential effective treatments, has lately directed its attention towards the "so-called" cognitive enhancers. This class of substances, by modulating cognitive processes involved in the development and/or persistence of the post-traumatic symptomatology, could be of great help in improving the outcome of psychotherapies and patients' prognosis. In this perspective, drugs acting on the endocannabinoid system are receiving great attention due to their dual ability to modulate memory processes on one hand, and to reduce anxiety and depression on the other. The purpose of the present review is to offer a thorough overview of both animal and human studies investigating the effects of cannabinoids on memory processes. First, we will briefly describe the characteristics of the endocannabinoid system and the most commonly used animal models of learning and memory. Then, studies investigating cannabinoid modulatory influences on memory consolidation, retrieval and extinction will be separately presented, and the potential benefits associated with each approach will be discussed. In the final section, we will review literature data reporting beneficial effects of cannabinoid drugs in PTSD patients. PMID:27456243

  6. The endocannabinoid system and Post Traumatic Stress Disorder (PTSD): From preclinical findings to innovative therapeutic approaches in clinical settings.

    PubMed

    Berardi, Andrea; Schelling, Gustav; Campolongo, Patrizia

    2016-09-01

    Post-Traumatic Stress Disorder (PTSD) is a psychiatric chronic disease developing in individuals after the experience of an intense and life-threatening traumatic event. The post-traumatic symptomatology encompasses alterations in memory processes, mood, anxiety and arousal. There is now consensus in considering the disease as an aberrant adaptation to traumatic stress. Pharmacological research, aimed at the discovery of new potential effective treatments, has lately directed its attention towards the "so-called" cognitive enhancers. This class of substances, by modulating cognitive processes involved in the development and/or persistence of the post-traumatic symptomatology, could be of great help in improving the outcome of psychotherapies and patients' prognosis. In this perspective, drugs acting on the endocannabinoid system are receiving great attention due to their dual ability to modulate memory processes on one hand, and to reduce anxiety and depression on the other. The purpose of the present review is to offer a thorough overview of both animal and human studies investigating the effects of cannabinoids on memory processes. First, we will briefly describe the characteristics of the endocannabinoid system and the most commonly used animal models of learning and memory. Then, studies investigating cannabinoid modulatory influences on memory consolidation, retrieval and extinction will be separately presented, and the potential benefits associated with each approach will be discussed. In the final section, we will review literature data reporting beneficial effects of cannabinoid drugs in PTSD patients.

  7. Development of an innovative decentralized treatment system for the reclamation and reuse of strong wastewater from rural community: Effects of elevated CO2 concentrations.

    PubMed

    Chen, Xiaochen; Fukushi, Kensuke

    2016-09-15

    In a previous study, a soil-plant-based natural treatment system was successfully developed for post-treatment of anaerobically digested strong wastewater full of potential nutrients (nitrogen, phosphorus, and potassium). For upgraded performance, an innovative decentralized treatment system was further developed, in which an anaerobic digestion stage and a natural treatment system stage are placed within a greenhouse. This allows the CO2 generated by the processing of wastewater and biogas consumption to be sequestrated within the greenhouse for elevating its concentration level and potentially enhance nutrient removal and recovery from the applied wastewater. To investigate the feasibility of the system, a bench-scale experiment was conducted using CO2 chambers. Valuable Kentucky bluegrass was planted in two soil types (red ball earth and black soil) at three CO2 concentrations (340 ppm, 900 ppm, and 1400 ppm). The results confirmed the positive effects of elevated CO2 concentration on the biomass production and turf quality of Kentucky bluegrass as well as the resulting higher nutrient recovery efficiencies. More importantly, it was demonstrated that the elevated CO2 concentration significantly stimulated the soil nitrifying microorganisms and thus improved the nitrogen removal efficiency (a critical issue in ecological wastewater treatment). A CO2 concentration of 1400 ppm is therefore recommended for use in the system. The mechanism underlying this phenomenon was shown to be an indirect effect, in which the higher CO2 concentration first positively influenced growing plants, which then stimulated the soil nitrifier communities. The effects of soil type (a design parameter) and hydraulic and nutrient loading rates (an operational parameter) on system performance were also examined. The results favored black soil for system establishment. Based on the findings of this study, our proposed system is thought to have the potential to be scaled up and adopted by

  8. Inflatable Aeroponic System

    NASA Technical Reports Server (NTRS)

    Pelt, Jennifer Van

    2005-01-01

    Aeroponics Internationals (AI) innovation is a self-contained, self-supporting, flexible low mass aeroponic crop production unit with integral environmental systems for the control and delivery of a nutrient mist to the roots. This FLEX Aeroponic System model was developed for commercialization as a result of the NASA SBIR Phase I contract for the research and development of a low-mass, Inflatable Aeroponic System (IAS) for producing pesticide-free lettuces, grains, peppers, tomatoes and other vegetables. The innovation addresses the needs of water and nutrient delivery systems technologies for food production in space. The inflatable nature of the innovation makes it lightweight, allowing it to be deflated so it takes up less volume during transportation and storage. It improves upon AI's current aeroponic system design that uses more rigid structures and takes advantage of vertical inclines to increase bio-mass production by over 600%.

  9. Innovative delivery systems for migraine: the clinical utility of a transdermal patch for the acute treatment of migraine.

    PubMed

    Rapoport, Alan M; Freitag, Fred; Pearlman, Starr H

    2010-11-01

    Migraine is a disabling, painful primary headache disorder that is associated with various combinations of neurological, gastrointestinal, autonomic and pain symptoms. Gastrointestinal disturbances associated with migraine, including nausea and vomiting, affect a majority of migraineurs and often result in a delay in taking or avoidance of pharmacological intervention. Gastric stasis and vomiting may lead to delayed or inconsistent absorption of orally administered medications. Many migraineurs awake early in the morning with their attack progressing and already associated with nausea and vomiting. As a result, there is a need for a novel, non-invasive, non-oral delivery system for fast and effective acute treatment of migraine. There are two non-oral delivery systems currently available in the US for the acute treatment of migraine: three nasal sprays and two injectable formulations. Although nasal sprays depend partially on nasal mucosal absorption, a significant amount of drug is swallowed, transits the stomach and is absorbed in the small intestine, which is not as rapid or effective a route of delivery for those migraineurs with gastric stasis. Sumatriptan is rapidly absorbed by subcutaneous injection with or without a needle, but the invasiveness and discomfort of the delivery, the high incidence of adverse events and the high recurrence rate all limit its use for many patients. Iontophoretic delivery of medication is a non-invasive transdermal approach that uses small amounts of electrical current to promote rapid movement of the ionized drug through the skin and into the systemic circulation. This delivery bypasses hepatic first-pass metabolism and also avoids gastric transit delay and slowing of small intestinal absorption associated with gastrointestinal stasis in migraineurs. Two pharmacokinetic studies have demonstrated that iontophoretic transdermal delivery of sumatriptan results in rapid and consistent achievement of therapeutic plasma concentrations

  10. Solar system positioning system

    NASA Technical Reports Server (NTRS)

    Penanen, Konstantin I.; Chui, Talso

    2006-01-01

    Power-rich spacecraft envisioned in Prometheus initiative open up possibilities for long-range high-rate communication. A constellation of spacecraft on orbits several A.U. from the Sun, equipped with laser transponders and precise clocks can be configured to measure their mutual distances to within few cm. High on-board power can create substantial non-inertial contribution to the spacecraft trajectory. We propose to alleviate this contribution by employing secondary ranging to a passive daughter spacecraft. Such constellation can form the basis of it navigation system capable of providing position information anywhere in the soIar system with similar accuracy. Apart from obvious Solar System exploration implications, this system can provide robust reference for GPS and its successors.

  11. Improving quality management systems of laboratories in developing countries: an innovative training approach to accelerate laboratory accreditation.

    PubMed

    Yao, Katy; McKinney, Barbara; Murphy, Anna; Rotz, Phil; Wafula, Winnie; Sendagire, Hakim; Okui, Scolastica; Nkengasong, John N

    2010-09-01

    The Strengthening Laboratory Management Toward Accreditation (SLMTA) program was developed to promote immediate, measurable improvement in laboratories of developing countries. The laboratory management framework, a tool that prescribes managerial job tasks, forms the basis of the hands-on, activity-based curriculum. SLMTA is implemented through multiple workshops with intervening site visits to support improvement projects. To evaluate the effectiveness of SLMTA, the laboratory accreditation checklist was developed and subsequently adopted by the World Health Organization Regional Office for Africa (WHO AFRO). The SLMTA program and the implementation model were validated through a pilot in Uganda. SLMTA yielded observable, measurable results in the laboratories and improved patient flow and turnaround time in a laboratory simulation. The laboratory staff members were empowered to improve their own laboratories by using existing resources, communicate with clinicians and hospital administrators, and advocate for system strengthening. The SLMTA program supports laboratories by improving management and building preparedness for accreditation.

  12. CRISPR/Cas9 system as an innovative genetic engineering tool: Enhancements in sequence specificity and delivery methods.

    PubMed

    Jo, Young-Il; Suresh, Bharathi; Kim, Hyongbum; Ramakrishna, Suresh

    2015-12-01

    While human gene therapy has gained significant attention for its therapeutic promise, CRISPR/Cas9 technology has made a breakthrough as an efficient genome editing tool by emulating prokaryotic immune defense mechanisms. Although many studies have found that CRISPR/Cas9 technology is more efficient, specific and manipulable than previous generations of gene editing tools, it can be further improved by elevating its overall efficiency in a higher frequency of genome modifications and reducing its off-target effects. Here, we review the development of CRISPR/Cas9 technology, focusing on enhancement of its sequence specificity, reduction of off-target effects and delivery systems. Moreover, we describe recent successful applications of CRISPR/Cas9 technology in laboratory and clinical studies.

  13. The multianalyser system of the three axes neutron spectrometer PUMA: Pilot experiments with the innovative multiplex technique

    NASA Astrophysics Data System (ADS)

    Sobolev, Oleg; Hoffmann, Ron; Gibhardt, Holger; Jünke, Norbert; Knorr, Andreas; Meyer, Volker; Eckold, Götz

    2015-02-01

    A new type of multiplex technique for three axes neutron spectrometers has been realized and successfully commissioned at the PUMA spectrometer at FRM II. Consisting of eleven analyser-detector channels which can be configured individually, this technique is especially suitable for kinetic experiments where a single excitation spectrum is recorded as a function of time without the need to move the spectrometer. On a time-scale of seconds an entire spectrum can be recorded thus allowing users to monitor changes during fast kinetic processes in single shot experiments without the need for stroboscopic techniques. Moreover, the multianalyser system provides an efficient and rapid tool for mapping excitations in (Q,ω)-space. The results of pilot experiments demonstrate the performance of this new technique and a user-friendly software is presented which assists users during their experiments.

  14. CRISPR/Cas9 system as an innovative genetic engineering tool: Enhancements in sequence specificity and delivery methods.

    PubMed

    Jo, Young-Il; Suresh, Bharathi; Kim, Hyongbum; Ramakrishna, Suresh

    2015-12-01

    While human gene therapy has gained significant attention for its therapeutic promise, CRISPR/Cas9 technology has made a breakthrough as an efficient genome editing tool by emulating prokaryotic immune defense mechanisms. Although many studies have found that CRISPR/Cas9 technology is more efficient, specific and manipulable than previous generations of gene editing tools, it can be further improved by elevating its overall efficiency in a higher frequency of genome modifications and reducing its off-target effects. Here, we review the development of CRISPR/Cas9 technology, focusing on enhancement of its sequence specificity, reduction of off-target effects and delivery systems. Moreover, we describe recent successful applications of CRISPR/Cas9 technology in laboratory and clinical studies. PMID:26434948

  15. The Development of a Family of Lightweight and Wide Swath Uav Camera Systems around AN Innovative Dual-Sensor On-Single Detector

    NASA Astrophysics Data System (ADS)

    Delauré, B.; Michiels, B.; Lewyckyj, N.; Van Achteren, T.

    2013-08-01

    Together with a Belgian industrial consortium VITO has developed the lightweight camera system MEDUSA. It combines high spatial resolution with a wide swath to support missions for large scale mapping and disaster monitoring applications. MEDUSA has been designed to be operated on a solar-powered unmanned aerial vehicle flying in the stratosphere. The camera system contains a custom designed CMOS imager with 2 sensors (each having 10000 × 1200 pixels) on 1 chip. One sensor is panchromatic, one is equipped with colour filters. The MEDUSA flight model camera has passed an extensive test campaign and is ready to conduct its maiden flight. First airborne test flights with an engineering model version of the camera have been executed to validate the functionality and the performance of the camera. An image stitching work flow has been developed in order to generate an image composite in near real time of the acquired images. The unique properties of the dual-sensor-on-single-chip detector triggered the development of 2 new camera designs which are currently in preparation. MEDUSA-low is a modified camera system optimised for compatibility with more conventional UAV systems with a payload capacity of 5-10 kg flying at an altitude around 1 km. Its camera acquires both panchromatic and colour images. The MEDUSA geospectral camera is an innovative hyperspectral imager which is equipped with a spatially varying spectral filter installed in front of one of the two sensors. It acquires both hyperspectral and broad band high spatial resolution image data from one and the same camera.

  16. LC/LC-MS/MS of an Innovative Prostate Human Epithelial Cancer (PHEC) in vitro Model System

    PubMed Central

    Lapek, John D.; McGrath, James L.; Ricke, William A.; Friedman, Alan E.

    2012-01-01

    This work describes the proteomic characterization of a novel in vitro prostate cancer model system, the clonal Prostatic Human Epithelial Cancer (PHEC) cell lines. The model is composed of three cell lines representing the three progressive cancer states found in vivo: non-tumorigenic, tumorigenic, and metastatic. The cell lines were evaluated for differential protein expression between states using two dimensional liquid:liquid chromatographic separation followed by mass spectral identification. The proteins from cellular extracts were first separated using liquid:liquid primary separation based on their isoelectric points and molecular masses. The resulting peptide fractions were applied to liquid chromatography mass spectrometry (LCMS) separation for mass determination and protein identification based on Mascot database inquiry. Over 200 proteins that change expression over the course of progression of this in vitro prostate cancer model were discovered during the comparative analysis of the three cell lines. The importance of these proteins on prostate cancer progression remains to be elucidated with further characterizations. The combination of the two dimensional liquid:liquid separation and mass spectral identifications was used to successfully analyze differential protein expression between multiple cell lines. PMID:22425387

  17. Micro-electromechanical Systems for Probing Novel Strain Physics and Innovative Strain Devices in 2D Materials

    NASA Astrophysics Data System (ADS)

    Christopher, Jason; Vutukuru, Mounika; Bishop, David; Swan, Anna; Goldberg, Bennett

    Straining 2D materials can dramatically change electrical, thermal and optical properties and can even cause unconventional behavior such as generating pseudo-magnetic fields. However attempts at probing these effects have been hindered by the difficulty involved with precisely straining these materials. Here we present micro-electromechanical systems (MEMS) as an ideal platform for straining 2D materials because they are readily compatible with existing electronics and their size makes them compatible with 2D materials. Additionally the MEMS platform does more than facilitate experimentation; by freeing us to think of strain as dynamical it makes a whole new class of devices practical for next generation technology. To demonstrate the power of this platform we have for the first time measured the strain response of the Raman and photoluminescence spectra of suspended MoS2, and measured the friction force between MoS2 and the MEMS structure. This talk will touch on the basics of designing MEMS structures for straining 2D materials, how to transfer 2D materials onto MEMS without break either, proof of concept experimental results, and next steps in developing the MEMS platform. This work is supported by NSF DMR Grant 1411008, and author J. Christopher thanks the NDSEG program for its support.

  18. Innovative ammonia stripping with an electrolyzed water system as pretreatment of thermally hydrolyzed wasted sludge for anaerobic digestion.

    PubMed

    Park, Seyong; Kim, Moonil

    2015-01-01

    In this study, the anaerobic digestion of thermally hydrolyzed wasted sludge (THWS) with a high concentration of ammonia was carried out through combining with an ammonia stripping and an electrolyzed water system (EWS). The EWS produced acidic water (pH 2-3) at the anode and alkaline water (pH 11-12) at the cathode with an electro-diaphragm between the electrodes that could be applied to ammonia stripping. The ammonia stripping efficiency was strongly dependent on the pH and aeration rate, and the ammonium ion removal rate followed pseudo-first-order kinetics. From the BMP test, the methane yield of THWS after ammonia stripping using the EWS was 2.8 times higher than that of the control process (raw THWS without ammonia stripping). Furthermore, both methane yield and ammonium removal efficiency were higher in this study than in previous studies. Since ammonia stripping with the EWS does not require any chemicals for pH control, no precipitated sludge is produced and anaerobic microorganisms are not inhibited by cations. Therefore, ammonia stripping using the EWS could be an effective method for digestion of wastewater with a high concentration of ammonium nitrogen.

  19. Advances in psoriasis physiopathology and treatments: Up to date of mechanistic insights and perspectives of novel therapies based on innovative skin drug delivery systems (ISDDS).

    PubMed

    Sala, M; Elaissari, A; Fessi, H

    2016-10-10

    Psoriasis is a chronic inflammatory disease affecting mainly the skin but which can be complicated by psoriatic arthritis (PsA).This autoimmune skin disorder concerns 2-5% of the world population. To date, the physiopathology of psoriasis is not still completely elucidated but many researches are ongoing which have led for example to the discovery of the Th17/Th22 pathway. The conventional therapeutic approaches (local or systemic route) appeal to various classes of drugs with complex mechanisms of action and non-negligible side effects. Although there is no therapy capable to cure psoriasis, the current goal is to relieve symptoms as longer as possible with a good benefit/risk ratio. That is one of the principal limits of conventional antipsoriatic drugs. New formulations based on nanoencapsulation are a promising opportunity to answer to this limit by offering an optimization of the conventional antipsoriatic drug use (higher activity, lower side effects and frequency of application, etc.). Herein, we tried to put in perspective the mechanistic insights (histological and immunological views) proposed into scientific literature these last years in order to have a better comprehension of psoriasis physiopathology resulting in skin lesions and PsA. The therapeutic armamentarium and the different strategies in the management of psoriasis are discussed in greater details. To finish, the field of encapsulation in nanoparticles is broached in order to put forward recent advances in innovative skin drug delivery systems (ISDDSs) of antipsoriatic active agents for a better efficacy, safety and compliance.

  20. Encouraging innovation.

    PubMed

    Hyman, Anthony A

    2014-02-01

    Innovation is central to the scientific endeavor, and yet the current system of funding in the United States discourages innovation, especially in the young. Subtle alterations to the funding system, guided in part by the success of the European Research Council, could have major effects on encouraging innovation.

  1. IEEE 802.14.5/ZigBee Based WSNs - WPANs and Innovative Application in Medical Health Care Systems.

    PubMed

    Zhang, Zhongwei

    2014-01-01

    With recent developments in wireless networks field and in sensing technology, new and innovative medical applications based on the wireless sensor networks (WSN) technology are being developed in the research lab or commercial sectors. The key problem of WSN based application in the medical and health care domain is to get the message with the bounded delays and/or real-time data such as the signal of falls, the alarm of heart attacks traversed to the cluster at where the emergence unit located while delivering the steady flows of data with a certain level of Quality of Service (QoS). In this paper, we address this problem by proposing to use a periodic scheduling-Time Division Cluster Schedule (TDCS), to avoid the flow collision while meeting the end-to-end delay deadlines. The proposed scheduling mechanism has been studied on simulated Wireless sensor networks with a cluster tree topology on which the OPEN-ZB simulation model is adopted. The preliminary results shown that it is feasible to guarantee the real time medical data delivered on time over the low data rate wireless sensor networks when deployed at medical and/or health care domain, under the governance of the TDCS mechanism.

  2. Multipurpose hyperspectral imaging system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A hyperspectral imaging system of high spectral and spatial resolution that incorporates several innovative features has been developed to incorporate a focal plane scanner (U.S. Patent 6,166,373). This feature enables the system to be used for both airborne/spaceborne and laboratory hyperspectral i...

  3. Environmental impacts of innovative dairy farming systems aiming at improved internal nutrient cycling: A multi-scale assessment.

    PubMed

    de Vries, W; Kros, J; Dolman, M A; Vellinga, Th V; de Boer, H C; Gerritsen, A L; Sonneveld, M P W; Bouma, J

    2015-12-01

    Several dairy farms in the Netherlands aim at reducing environmental impacts by improving the internal nutrient cycle (INC) on their farm by optimizing the use of available on-farm resources. This study evaluates the environmental performance of selected INC farms in the Northern Friesian Woodlands in comparison to regular benchmark farms using a Life Cycle Assessment. Regular farms were selected on the basis of comparability in terms of milk production per farm and per hectare, soil type and drainage conditions. In addition, the environmental impacts of INC farming at landscape level were evaluated with the integrated modelling system INITIATOR, using spatially explicit input data on animal numbers, land use, agricultural management, meteorology and soil, assuming that all farms practised the principle of INC farming. Impact categories used at both farm and landscape levels were global warming potential, acidification potential and eutrophication potential. Additional farm level indicators were land occupation and non-renewable energy use, and furthermore all farm level indicators were also expressed per kg fat and protein corrected milk. Results showed that both on-farm and off-farm non-renewable energy use was significantly lower at INC farms as compared with regular farms. Although nearly all other environmental impacts were numerically lower, both on-farm and off-farm, differences were not statistically significant. Nitrogen losses to air and water decreased by on average 5 to 10% when INC farming would be implemented for the whole region. The impact of INC farming on the global warming potential and eutrophication potential was, however, almost negligible (<2%) at regional level. This was due to a negligible impact on the methane emissions and on the surplus and thereby on the soil accumulation and losses of phosphorus to water at INC farms, illustrating the focus of these farms on closing the nitrogen cycle. PMID:26231773

  4. Environmental impacts of innovative dairy farming systems aiming at improved internal nutrient cycling: A multi-scale assessment.

    PubMed

    de Vries, W; Kros, J; Dolman, M A; Vellinga, Th V; de Boer, H C; Gerritsen, A L; Sonneveld, M P W; Bouma, J

    2015-12-01

    Several dairy farms in the Netherlands aim at reducing environmental impacts by improving the internal nutrient cycle (INC) on their farm by optimizing the use of available on-farm resources. This study evaluates the environmental performance of selected INC farms in the Northern Friesian Woodlands in comparison to regular benchmark farms using a Life Cycle Assessment. Regular farms were selected on the basis of comparability in terms of milk production per farm and per hectare, soil type and drainage conditions. In addition, the environmental impacts of INC farming at landscape level were evaluated with the integrated modelling system INITIATOR, using spatially explicit input data on animal numbers, land use, agricultural management, meteorology and soil, assuming that all farms practised the principle of INC farming. Impact categories used at both farm and landscape levels were global warming potential, acidification potential and eutrophication potential. Additional farm level indicators were land occupation and non-renewable energy use, and furthermore all farm level indicators were also expressed per kg fat and protein corrected milk. Results showed that both on-farm and off-farm non-renewable energy use was significantly lower at INC farms as compared with regular farms. Although nearly all other environmental impacts were numerically lower, both on-farm and off-farm, differences were not statistically significant. Nitrogen losses to air and water decreased by on average 5 to 10% when INC farming would be implemented for the whole region. The impact of INC farming on the global warming potential and eutrophication potential was, however, almost negligible (<2%) at regional level. This was due to a negligible impact on the methane emissions and on the surplus and thereby on the soil accumulation and losses of phosphorus to water at INC farms, illustrating the focus of these farms on closing the nitrogen cycle.

  5. Peptide-MHC Cellular Microarray with Innovative Data Analysis System for Simultaneously Detecting Multiple CD4 T-Cell Responses

    PubMed Central

    Ge, Xinhui; Gebe, John A.; Bollyky, Paul L.; James, Eddie A.; Yang, Junbao; Stern, Lawrence J.; Kwok, William W.

    2010-01-01

    Background Peptide:MHC cellular microarrays have been proposed to simultaneously characterize multiple Ag-specific populations of T cells. The practice of studying immune responses to complicated pathogens with this tool demands extensive knowledge of T cell epitopes and the availability of peptide:MHC complexes for array fabrication as well as a specialized data analysis approach for result interpretation. Methodology/Principal Findings We co-immobilized peptide:DR0401 complexes, anti-CD28, anti-CD11a and cytokine capture antibodies on the surface of chamber slides to generate a functional array that was able to detect rare Ag-specific T cell populations from previously primed in vitro T cell cultures. A novel statistical methodology was also developed to facilitate batch processing of raw array-like data into standardized endpoint scores, which linearly correlated with total Ag-specific T cell inputs. Applying these methods to analyze Influenza A viral antigen-specific T cell responses, we not only revealed the most prominent viral epitopes, but also demonstrated the heterogeneity of anti-viral cellular responses in healthy individuals. Applying these methods to examine the insulin producing beta-cell autoantigen specific T cell responses, we observed little difference between autoimmune diabetic patients and healthy individuals, suggesting a more subtle association between diabetes status and peripheral autoreactive T cells. Conclusions/Significance The data analysis system is reliable for T cell specificity and functional testing. Peptide:MHC cellular microarrays can be used to obtain multi-parametric results using limited blood samples in a variety of translational settings. PMID:20634998

  6. An innovative multi dof TMD system for motorcycle handlebars designed to reduce structural vibrations and human exposure

    NASA Astrophysics Data System (ADS)

    Agostoni, S.; Cheli, F.; Leo, E.; Pezzola, M.

    2012-08-01

    Motor vehicle ride comfort is mainly affected by reciprocating engine inertia unbalances. These forces are transmitted to the driver through the main frame, the engine mounts, and the auxiliary sub systems—all components with which he physically comes into contact. On-road traction vehicle engines are mainly characterized by transient exercise. Thus, an excitation frequency range from 800 RPM (≈15 Hz for stationary vehicles) up to 15,000 RPM (≈250 Hz as a cut off condition) occurs. Several structural resonances are induced by the unbalancing forces spectrum, thus exposing the driver to amplified vibrations. The aim of this research is to reduce driver vibration exposure, by acting on the modal response of structures with which the driver comes into contact. An experimental methodology, capable of identifying local vibration modes was developed. The application of this methodology on a reference vehicle allows us to detect if/when/how the above mentioned resonances are excited. Numerical models were used to study structural modifications. In this article, a handlebar equipped with an innovative multi reciprocating tuned mass damper was optimized. All structural modifications were designed, developed and installed on a vehicle. Modal investigations were then performed in order to predict modification efficiency. Furthermore, functional solution efficiency was verified during sweep tests performed on a target vehicle, by means of a roller bench capable of replicating on-road loads. Three main investigation zones of the vehicle were detected and monitored using accelerometers: (1) engine mounts, to characterize vibration emissions; (2) bindings connecting the engine to the frame, in order to detect vibration transfer paths, with particular attention being paid to local dynamic amplifications due to compliances and (3) the terminal components with which the driver comes into contact.

  7. Immune System

    MedlinePlus

    ... How Can I Help a Friend Who Cuts? Immune System KidsHealth > For Teens > Immune System Print A A ... could put us out of commission. What the Immune System Does The immune (pronounced: ih-MYOON) system, which ...

  8. Innovations in major system reconfiguration in England: a study of the effectiveness, acceptability and processes of implementation of two models of stroke care

    PubMed Central

    2013-01-01

    Background Significant changes in provision of clinical care within the English National Health Service (NHS) have been discussed in recent years, with proposals to concentrate specialist services in fewer centres. Stroke is a major public health issue, accounting for over 10% of deaths in England and Wales, and much disability among survivors. Variations have been highlighted in stroke care, with many patients not receiving evidence-based care. To address these concerns, stroke services in London and Greater Manchester were reorganised, although different models were implemented. This study will analyse processes involved in making significant changes to stroke care services over a short time period, and the factors influencing these processes. We will examine whether the changes have delivered improvements in quality of care and patient outcomes; and, in light of this, whether the significant extra financial investment represented good value for money. Methods/design This study brings together quantitative data on ‘what works and at what cost?’ with qualitative data on ‘understanding implementation and sustainability’ to understand major system change in two large conurbations in England. Data on processes of care and their outcomes (e.g. morbidity, mortality, and cost) will be analysed to evidence services’ performance before and after reconfiguration. The evaluation draws on theories related to the dissemination and sustainability of innovations and the ‘social matrix’ underlying processes of innovation. We will conduct a series of case studies based on stakeholder interviews and documentary analysis. These will identify drivers for change, how the reconfigurations were governed, developed, and implemented, and how they influenced service quality. Discussion The research faces challenges due to: the different timings of the reconfigurations; the retrospective nature of the evaluation; and the current organisational turbulence in the English NHS

  9. New innovative electrocoagulation (EC) treatment technology for BWR colloidal iron utilizing the seeding and filtration electronically (SAFET{sup TM}) system

    SciTech Connect

    Denton, Mark S.; Bostick, William D.

    2007-07-01

    is 1) to break the colloid (i.e., break the outer radius repulsive charges of the similar charged colloidal particles), 2) allow these particles to now flocculate (floc), and 3) form a type of floc that is more readily filterable, and, thus, de-waterable. This task has been carried out with the innovative application of electronically seeding the feed stream with the metal of choice, and without the addition of chemicals common to ferri-flocking, or polymer addition. This patent-pending new system and technique is called Seeding And Filtration Electronically, or the SAFE{sup TM} System. Once the colloid has been broken and flocking has begun, removal of the resultant floc can be carried out by standard, back-washable (or, in simple cases, dead-end) filters; or simply in de-waterable HICs or liners. Such applications include low level radwaste (LLW) from both PWRs and BWRs, fuel pools, storage basins, salt water collection tanks, etc. For the removal of magnetic materials, such as some BWR irons, an Electro Magnetic Filter (EMF) was developed to couple with the Electro Coagulation (EC), (or metal-Flocking) Unit. In the advent that the waste stream primarily contains magnetic materials (e.g., boiler condensates and magnetite, and he-magnetite from BWRs), the material was simply filtered using the EMF. Bench-, pilot- and full-scale systems have been assembled and applied on actual plant waste samples quite successfully. The effects of initial feed pH and conductivity, as well as flocculation retention times was examined prior to applying the production equipment into the field. Since the initial studies (Denton, et al, EPRI, 2006), the ultimate success of field applications is now being demonstrated as the next development phase. For such portable field demonstrations and demand systems, a fully self enclosed (secondary containment) EC system was first developed and assembled in a modified B 25 Box (Floc-In-A-Box) and is being deployed to a number of NPP sites. Finally

  10. From "farm to fork" strawberry system: current realities and potential innovative scenarios from life cycle assessment of non-renewable energy use and green house gas emissions.

    PubMed

    Girgenti, Vincenzo; Peano, Cristiana; Baudino, Claudio; Tecco, Nadia

    2014-03-01

    In this study, we analysed the environmental profile of the strawberry industry in Northern Italy. The analysis was conducted using two scenarios as reference systems: strawberry crops grown in unheated plastic tunnels using currently existing cultivation techniques, post-harvest management practices and consumption patterns (scenario 1) and the same strawberry cultivation chain in which some of the materials used were replaced with bio-based materials (scenario 2). In numerous studies, biodegradable polymers have been shown to be environmentally friendly, thus potentially reducing environmental impacts. These materials can be recycled into carbon dioxide and water through composting. Many materials, such as Mater-BI® and PLA®, are also derived from renewable resources. The methodology chosen for the environmental analysis was a life cycle assessment (LCA) based on a consequential approach developed to assess a product's overall environmental impact from the production system to its usage and disposal. In the field stage, a traditional mulching film (non-biodegradable) could be replaced with a biodegradable product. This change would result in waste production of 0 kg/ha for the bio-based product compared to 260 kg/ha of waste for polyethylene (PE). In the post-harvest stage, the issue addressed was the use and disposal of packaging materials. The innovative scenario evaluated herein pertains to the use of new packaging materials that increase the shelf life of strawberries, thereby decreasing product losses while increasing waste management efficiency at the level of a distribution platform and/or sales outlet. In the event of product deterioration or non-sale of the product, the packaging and its contents could be collected together as organic waste without any additional processes because the packaging is compostable according to EN13432. Scenario 2 would achieve reductions of 20% in the global warming potential and non-renewable energy impact categories. PMID

  11. From "farm to fork" strawberry system: current realities and potential innovative scenarios from life cycle assessment of non-renewable energy use and green house gas emissions.

    PubMed

    Girgenti, Vincenzo; Peano, Cristiana; Baudino, Claudio; Tecco, Nadia

    2014-03-01

    In this study, we analysed the environmental profile of the strawberry industry in Northern Italy. The analysis was conducted using two scenarios as reference systems: strawberry crops grown in unheated plastic tunnels using currently existing cultivation techniques, post-harvest management practices and consumption patterns (scenario 1) and the same strawberry cultivation chain in which some of the materials used were replaced with bio-based materials (scenario 2). In numerous studies, biodegradable polymers have been shown to be environmentally friendly, thus potentially reducing environmental impacts. These materials can be recycled into carbon dioxide and water through composting. Many materials, such as Mater-BI® and PLA®, are also derived from renewable resources. The methodology chosen for the environmental analysis was a life cycle assessment (LCA) based on a consequential approach developed to assess a product's overall environmental impact from the production system to its usage and disposal. In the field stage, a traditional mulching film (non-biodegradable) could be replaced with a biodegradable product. This change would result in waste production of 0 kg/ha for the bio-based product compared to 260 kg/ha of waste for polyethylene (PE). In the post-harvest stage, the issue addressed was the use and disposal of packaging materials. The innovative scenario evaluated herein pertains to the use of new packaging materials that increase the shelf life of strawberries, thereby decreasing product losses while increasing waste management efficiency at the level of a distribution platform and/or sales outlet. In the event of product deterioration or non-sale of the product, the packaging and its contents could be collected together as organic waste without any additional processes because the packaging is compostable according to EN13432. Scenario 2 would achieve reductions of 20% in the global warming potential and non-renewable energy impact categories.

  12. Experimental and numerical investigations of internal heat transfer in an innovative trailing edge blade cooling system: stationary and rotation effects, part 1—experimental results

    NASA Astrophysics Data System (ADS)

    Beniaiche, Ahmed; Ghenaiet, Adel; Facchini, Bruno

    2016-05-01

    The aero-thermal behavior of the flow field inside 30:1 scaled model reproducing an innovative smooth trailing edge of shaped wedge discharge duct with one row of enlarged pedestals have been investigated in order to determine the effect of rotation, inlet velocity and blowing conditions effects, for Re = 20,000 and 40,000 and Ro = 0-0.23. Two configurations are presented: with and without open tip configurations. Thermo-chromic liquid crystals technique is used to ensure a local measurement of the heat transfer coefficient on the blade suction side under stationary and rotation conditions. Results are reported in terms of detailed 2D HTC maps on the suction side surface as well as the averaged Nusselt number inside the pedestal ducts. Two correlations are proposed, for both closed and open tip configurations, based on the Re, Pr, Ro and a new non-dimensional parameter based on the position along the radial distance, to assess a reliable estimation of the averaged Nusselt number at the inter-pedestal region. A good agreement is found between prediction and experimental data with about ±10 to ±12 % of uncertainty, for the simple form correlation, and about ±16 % using a complex form. The obtained results help to predict the flow field visualization and the evaluation of the aero-thermal performance of the studied blade cooling system during the design step.

  13. Are the UK systems of innovation and evaluation of medical devices compatible? The role of NICE's Medical Technologies Evaluation Programme (MTEP).

    PubMed

    Chapman, A M; Taylor, C A; Girling, A J

    2014-08-01

    The economic evaluation of medical products and services is increasingly prioritised by healthcare decision makers and plays a key role in informing funding allocation decisions. It is well known that there are a number of methodological difficulties in the health technology assessment of medical devices, particularly in the provision of efficacy evidence. By contrasting devices with pharmaceuticals, the way in which the differing systems of innovation mould the UK's industry landscape is described and substantiated with market statistics. In recognition of the challenges faced by industry, as well as the growing need for cost-effective allocation of National Health Service (NHS) resources, the National Institute for Health and Care Excellence (NICE) led the development of the Medical Technologies Evaluation Programme (MTEP), which launched in 2009/2010. The review of the UK's medical devices market supports the programme's three principal aims: to simplify access to evaluation, speed up the process, and increase evaluative capacity for devices within NICE. However, an analysis of the output of MTEP's first 3 years suggests that it has some way to go to meet each of these aims.

  14. Experimental and numerical investigations of internal heat transfer in an innovative trailing edge blade cooling system: stationary and rotation effects, part 2: numerical results

    NASA Astrophysics Data System (ADS)

    Beniaiche, Ahmed; Ghenaiet, Adel; Carcasci, Carlo; Facchini, Bruno

    2016-05-01

    This paper presents a numerical validation of the aero-thermal study of a 30:1 scaled model reproducing an innovative trailing edge with one row of enlarged pedestals under stationary and rotating conditions. A CFD analysis was performed by means of commercial ANSYS-Fluent modeling the isothermal air flow and using k-ω SST turbulence model and an isothermal air flow for both static and rotating conditions (Ro up to 0.23). The used numerical model is validated first by comparing the numerical velocity profiles distribution results to those obtained experimentally by means of PIV technique for Re = 20,000 and Ro = 0-0.23. The second validation is based on the comparison of the numerical results of the 2D HTC maps over the heated plate to those of TLC experimental data, for a smooth surface for a Reynolds number = 20,000 and 40,000 and Ro = 0-0.23. Two-tip conditions were considered: open tip and closed tip conditions. Results of the average Nusselt number inside the pedestal ducts region are presented too. The obtained results help to predict the flow field visualization and the evaluation of the aero-thermal performance of the studied blade cooling system during the design step.

  15. Operating Systems.

    ERIC Educational Resources Information Center

    Denning, Peter J.; Brown, Robert L.

    1984-01-01

    A computer operating system spans multiple layers of complexity, from commands entered at a keyboard to the details of electronic switching. In addition, the system is organized as a hierarchy of abstractions. Various parts of such a system and system dynamics (using the Unix operating system as an example) are described. (JN)

  16. Material and energy recovery in integrated waste management systems: an innovative approach for the characterization of the gaseous emissions from residual MSW bio-drying.

    PubMed

    Ragazzi, M; Rada, E C; Antolini, D

    2011-01-01

    In the sector of residual municipal solid waste management an increasing attention is put towards the role of biological treatments like bio-drying and bio-stabilization in order to decrease the need of landfilling volumes. The literature shows a lack of information concerning the emission factor of pollutants released from these processes. The available data are generally spot characterizations of concentration and air flow-rate that are used together in order to assess the emission factors. This approach caused significant differences among the available data as the release of pollutants is not steady. This paper belongs to a group of six papers concerning a research on material and energy recovery in integrated waste management systems, developed by a network of five universities. The contribution of the University of Trento, focuses on the bio-drying process with the following targets: (a) developing an innovative low cost method of sampling/measurement able to take into account the dynamics of release of pollutants; (b) checking the efficiency of a bio-filter; (c) verifying the variability of generation of some pollutants; (d) generating emission factors. The research was developed using a bio-drying pilot plant. As a treatment of the process air, the bio-reactor was coupled with a bio-filter. The emissions were characterized using an original approach based on the adoption of two measurement chambers suitable for hosting passive samplers. The passive samplers allowed the characterization of VOCs, N(2)O, NH(3) and H(2)S. A bio-chemical model, useful for energy and mass balances, supported the interpretation of the presented bio-drying run.

  17. Material and energy recovery in integrated waste management systems: An innovative approach for the characterization of the gaseous emissions from residual MSW bio-drying

    SciTech Connect

    Ragazzi, M.; Rada, E.C.; Antolini, D.

    2011-09-15

    In the sector of residual municipal solid waste management an increasing attention is put towards the role of biological treatments like bio-drying and bio-stabilization in order to decrease the need of landfilling volumes. The literature shows a lack of information concerning the emission factor of pollutants released from these processes. The available data are generally spot characterizations of concentration and air flow-rate that are used together in order to assess the emission factors. This approach caused significant differences among the available data as the release of pollutants is not steady. This paper belongs to a group of six papers concerning a research on material and energy recovery in integrated waste management systems, developed by a network of five universities. The contribution of the University of Trento, focuses on the bio-drying process with the following targets: (a) developing an innovative low cost method of sampling/measurement able to take into account the dynamics of release of pollutants; (b) checking the efficiency of a bio-filter; (c) verifying the variability of generation of some pollutants; (d) generating emission factors. The research was developed using a bio-drying pilot plant. As a treatment of the process air, the bio-reactor was coupled with a bio-filter. The emissions were characterized using an original approach based on the adoption of two measurement chambers suitable for hosting passive samplers. The passive samplers allowed the characterization of VOCs, N{sub 2}O, NH{sub 3} and H{sub 2}S. A bio-chemical model, useful for energy and mass balances, supported the interpretation of the presented bio-drying run.

  18. DLESE Teaching Box Pilot Project: Developing a Replicable Model for Collaboratively Creating Innovative Instructional Sequences Using Exemplary Resources in the Digital Library for Earth System Education (DLESE)

    NASA Astrophysics Data System (ADS)

    Weingroff, M.

    2004-12-01

    Before the advent of digital libraries, it was difficult for teachers to find suitable high-quality resources to use in their teaching. Digital libraries such as DLESE have eased the task by making high quality resources more easily accessible and providing search mechanisms that allow teachers to 'fine tune' the criteria over which they search. Searches tend to return lists of resources with some contextualizing information. However, teachers who are teaching 'out of discipline' or who have minimal training in science often need additional support to know how to use and sequence them. The Teaching Box Pilot Project was developed to address these concerns, bringing together educators, scientists, and instructional designers in a partnership to build an online framework to fully support innovative units of instruction about the Earth system. Each box integrates DLESE resources and activities, teaching tips, standards, concepts, teaching outcomes, reviews, and assessment information. Online templates and best practice guidelines are being developed that will enable teachers to create their own boxes or customize existing ones. Two boxes have been developed so far, one on weather for high school students, and one on the evidence for plate tectonics for middle schoolers. The project has met with significant enthusiasm and interest, and we hope to expand it by involving individual teachers, school systems, pre-service programs, and universities in the development and use of teaching boxes. A key ingredient in the project's success has been the close collaboration between the partners, each of whom has brought unique experiences, perspectives, knowledge, and skills to the project. This first effort involved teachers in the San Francisco Bay area, the University of California Museum of Paleontology, San Francisco State University, U.S. Geological Survey, and DLESE. This poster will allow participants to explore one of the teaching boxes. We will discuss how the boxes were

  19. PNNL Tests Fish Passage System

    SciTech Connect

    Colotelo, Alison

    2015-03-13

    Scientists from PNNL are testing a fish transportation system developed by Whooshh Innovations. The Whooshh system uses a flexible tube that works a bit like a vacuum, guiding fish over hydroelectric dams or other structures. Compared to methods used today, this system could save money while granting fish quicker, safer passage through dams and hatcheries.

  20. Development and application of an innovative expert decision support system to manage sediments and to assess environmental risk in freshwater ecosystems.

    PubMed

    Dagnino, Alessandro; Bo, Tiziano; Copetta, Andrea; Fenoglio, Stefano; Oliveri, Caterina; Bencivenga, Mauro; Felli, Angelo; Viarengo, Aldo

    2013-10-01

    With the aim of supporting decision makers to manage contamination in freshwater environments, an innovative expert decision support system (EDSS) was developed. The EDSS was applied in a sediment quality assessment along the Bormida river (NW, Italy) which has been heavily contaminated by an upstream industrial site for more than a century. Sampling sites were classified by means of comparing chemical concentrations with effect-based target values (threshold and probable effect concentrations). The level of each contaminant and the combined toxic pressure were used to rank sites into three categories: (i) uncontaminated (8 sites), (ii) mildly contaminated (4) and (iii) heavily contaminated (19). In heavily contaminated sediments, an environmental risk index (EnvRI) was determined by means of integrating chemical data with ecotoxicological and ecological parameters (triad approach). In addition a sediment risk index (SedRI) was computed from combining chemical and ecotoxicological data. Eight sites exhibited EnvRI values ≥0.25, the safety threshold level (range of EnvRI values: 0.14-0.31) whereas SedRI exceeded the safety threshold level at 6 sites (range of SedRI values: 0.16-0.36). At sites classified as mildly contaminated, sublethal biomarkers were integrated with chemical data into a biological vulnerability index (BVI), which exceeded the safety threshold level at one site (BVI value: 0.28). Finally, potential human risk was assessed in selected stations (11 sites) by integrating genotoxicity biomarkers (GTI index falling in the range 0.00-0.53). General conclusions drawn from the EDSS data include: (i) in sites classified as heavily contaminated, only a few exhibited some significant, yet limited, effects on biodiversity; (ii) restrictions in re-using sediments from heavily contaminated sites found little support in ecotoxicological data; (iii) in the majority of the sites classified as mildly contaminated, tested organisms exhibited low response levels

  1. Crystal Systems.

    ERIC Educational Resources Information Center

    Schomaker, Verner; Lingafelter, E. C.

    1985-01-01

    Discusses characteristics of crystal systems, comparing (in table format) crystal systems with lattice types, number of restrictions, nature of the restrictions, and other lattices that can accidently show the same metrical symmetry. (JN)

  2. Systems Engineering

    NASA Technical Reports Server (NTRS)

    Pellerano, Fernando

    2015-01-01

    This short course provides information on what systems engineering is and how the systems engineer guides requirements, interfaces with the discipline leads, and resolves technical issues. There are many system-wide issues that either impact or are impacted by the thermal subsystem. This course will introduce these issues and illustrate them with real life examples.

  3. Delivery Systems.

    ERIC Educational Resources Information Center

    Hutchison, Betty

    This paper on delivery systems for preparing and training early childhood educators focuses on three main topics: (1) adequacy of delivery systems and access; (2) market influences on delivery systems; and (3) linking preparation and professional development components. Questions addressed include the following: Would the current preparation and…

  4. Integrated oxygen recovery system

    NASA Technical Reports Server (NTRS)

    Lee, M. Gene; Davenport, Ronald J.

    1993-01-01

    Life Systems has conceptualized an innovative Integrated Oxygen Recovery System (IORS) applicable to advanced mission air revitalization. The IORS provides the capability to electrochemically generate metabolic oxygen (O2) and recover O2 from the space habitat atmosphere via a carbon dioxide (CO2) reduction process within a single assembly. To achieve this capability, the IORS utilizes a Solid Metal Cathode (SMC) water electrolysis unit that simultaneously serves as the Sabatier CO2 reduction reactor. The IORS enables two major life support systems currently baselined in closed loop air revitalization systems to be combined into one smaller, less complex system. This concept reduces fluidic and electrical interface requirements and eliminates a hydrogen (H2) interface. Life Systems is performing an evaluation of the IORS process directed at demonstrating performance and quantifying key physical characteristics including power, weight, and volume. The results of the checkout, shakedown, and initial parametric tests are summarized.

  5. Integrated oxygen recovery system

    NASA Technical Reports Server (NTRS)

    Lee, M. Gene; Davenport, Ronald J.

    1993-01-01

    Life Systems has conceptualized an innovative Integrated Oxygen Recovery System (IORS) applicable to advanced mission air revitalization. The IORS provides the capability to electrochemically generate metabolic oxygen (O2) and recover O2 from the space habitat atmosphere via a carbon dioxide (CO2) reduction process within a single assembly. To achieve this capability, the IORS utilizes a Solid Metal Cathode (SMC) water electrolysis unit that simultaneously serves as the Sabatier CO2 reduction reactor. The IORS enables two major life support systems currently baselined in closed loop air revitalization systems to be combined into one smaller, less complex system. This concept reduces fluidic and electrical interface requirements and eliminates a hydrogen (H2) interface. Life Systems is performing an evaluation of the IORS process directed at demonstrating performance and quantifying key physical characteristics including power, weight, and volume. Technical progress achieved during the first two months of the program is summarized.

  6. System Effectiveness

    SciTech Connect

    Powell, Danny H; Elwood Jr, Robert H

    2011-01-01

    An effective risk assessment system is needed to address the threat posed by an active or passive insider who, acting alone or in collusion, could attempt diversion or theft of nuclear material. It is critical that a nuclear facility conduct a thorough self-assessment of the material protection, control, and accountability (MPC&A) system to evaluate system effectiveness. Self-assessment involves vulnerability analysis and performance testing of the MPC&A system. The process should lead to confirmation that mitigating features of the system effectively minimize the threat, or it could lead to the conclusion that system improvements or upgrades are necessary to achieve acceptable protection against the threat. Analysis of the MPC&A system is necessary to understand the limits and vulnerabilities of the system to internal threats. Self-assessment helps the facility be prepared to respond to internal threats and reduce the risk of theft or diversion of nuclear material. MSET is a self-assessment or inspection tool utilizing probabilistic risk assessment (PRA) methodology to calculate the system effectiveness of a nuclear facility's MPC&A system. MSET analyzes the effectiveness of an MPC&A system based on defined performance metrics for MPC&A functions based on U.S. and international best practices and regulations. A facility's MC&A system can be evaluated at a point in time and reevaluated after upgrades are implemented or after other system changes occur. The total system or specific subareas within the system can be evaluated. Areas of potential performance improvement or system upgrade can be assessed to determine where the most beneficial and cost-effective improvements should be made. Analyses of risk importance factors show that sustainability is essential for optimal performance. The analyses reveal where performance degradation has the greatest detrimental impact on total system risk and where performance improvements have the greatest reduction in system risk

  7. From Small Seeds Grow Fruitful Trees: How the PHelpS Peer Help System Stimulated a Diverse and Innovative Research Agenda over 15 Years

    ERIC Educational Resources Information Center

    Vassileva, J.; McCalla, G. I.; Greer, J. E.

    2016-01-01

    PHelpS was a system that helped Correctional Service Canada (CSC) workers to find appropriate helpers among their peers when they were encountering problems while interacting with the CSC database. This seemingly simple system had substantial, and surprising, ramifications. Over time it transformed each of our perspectives as to the issues facing…

  8. The Next Accreditation System.

    PubMed

    Kirk, Lynne M

    2016-02-01

    The Accreditation Council for Graduate Medical Education has implemented a new accreditation system for graduate medical education in the United States. This system, called the Next Accreditation System, focuses on more continuous monitoring of the outcomes of residency training, and for high-quality programs, less on the detailed processes of that training. This allows programs to innovate to best meet the needs of their trainees and communities. This new system also reviews the clinical learning environment at each institution sponsoring graduate medical education, focusing on professionalism, trainee supervision, duty hour and fatigue management, care transitions, and integration of residents into patient safety and health care quality. This Next Accreditation System is too new to fully assess its outcomes in better preparing residents for medical practice. Assessments of its early implementation, however, suggest we can expect such outcomes in the near future. PMID:26859375

  9. Geothermal systems

    NASA Technical Reports Server (NTRS)

    Mohl, C.

    1978-01-01

    Several tasks of JPL related to geothermal energy are discussed. The major task is the procurement and test and evaluation of a helical screw drive (wellhead unit). A general review of geothermal energy systems is given. The presentation focuses attention on geothermal reservoirs in California, with graphs and charts to support the discussion. Included are discussions on cost analysis, systems maintenance, and a comparison of geothermal and conventional heating and cooling systems.

  10. [Information systems].

    PubMed

    Rodríguez Maniega, José Antonio; Trío Maseda, Reyes

    2005-03-01

    The arrival of victims of the terrorist attacks of 11 March at the hospital put the efficiency of its information systems to the test. To be most efficient, these systems should be simple and directed, above all, to the follow-up of victims and to providing the necessary information to patients and families. A specific and easy to use system is advisable. PMID:15771852

  11. CALUTRON SYSTEM

    DOEpatents

    Lawrence, E.O.

    1958-08-12

    A calutron system capable of functioning with only a portion of the separation tanks in the system operating is described. The invention is a calutron system comprssing a closed series of alternated tanks and electromagnets having a mid-yoke connecting intermediate positions of the series. dividing the series into twv-o portions, and thereby providing a closed magnetic path through either of the portions.

  12. Systemic darwinism.

    PubMed

    Winther, Rasmus Grønfeldt

    2008-08-19

    Darwin's 19th century evolutionary theory of descent with modification through natural selection opened up a multidimensional and integrative conceptual space for biology. We explore three dimensions of this space: explanatory pattern, levels of selection, and degree of difference among units of the same type. Each dimension is defined by a respective pair of poles: law and narrative explanation, organismic and hierarchical selection, and variational and essentialist thinking. As a consequence of conceptual debates in the 20th century biological sciences, the poles of each pair came to be seen as mutually exclusive opposites. A significant amount of 21st century research focuses on systems (e.g., genomic, cellular, organismic, and ecological/global). Systemic Darwinism is emerging in this context. It follows a "compositional paradigm" according to which complex systems and their hierarchical networks of parts are the focus of biological investigation. Through the investigation of systems, Systemic Darwinism promises to reintegrate each dimension of Darwin's original logical space. Moreover, this ideally and potentially unified theory of biological ontology coordinates and integrates a plurality of mathematical biological theories (e.g., self-organization/structure, cladistics/history, and evolutionary genetics/function). Integrative Systemic Darwinism requires communal articulation from a plurality of perspectives. Although it is more general than these, it draws on previous advances in Systems Theory, Systems Biology, and Hierarchy Theory. Systemic Darwinism would greatly further bioengineering research and would provide a significantly deeper and more critical understanding of biological reality. PMID:18697926

  13. Systemic darwinism.

    PubMed

    Winther, Rasmus Grønfeldt

    2008-08-19

    Darwin's 19th century evolutionary theory of descent with modification through natural selection opened up a multidimensional and integrative conceptual space for biology. We explore three dimensions of this space: explanatory pattern, levels of selection, and degree of difference among units of the same type. Each dimension is defined by a respective pair of poles: law and narrative explanation, organismic and hierarchical selection, and variational and essentialist thinking. As a consequence of conceptual debates in the 20th century biological sciences, the poles of each pair came to be seen as mutually exclusive opposites. A significant amount of 21st century research focuses on systems (e.g., genomic, cellular, organismic, and ecological/global). Systemic Darwinism is emerging in this context. It follows a "compositional paradigm" according to which complex systems and their hierarchical networks of parts are the focus of biological investigation. Through the investigation of systems, Systemic Darwinism promises to reintegrate each dimension of Darwin's original logical space. Moreover, this ideally and potentially unified theory of biological ontology coordinates and integrates a plurality of mathematical biological theories (e.g., self-organization/structure, cladistics/history, and evolutionary genetics/function). Integrative Systemic Darwinism requires communal articulation from a plurality of perspectives. Although it is more general than these, it draws on previous advances in Systems Theory, Systems Biology, and Hierarchy Theory. Systemic Darwinism would greatly further bioengineering research and would provide a significantly deeper and more critical understanding of biological reality.

  14. Innovation to improve health care provision and health systems in sub-Saharan Africa - promoting agency in mid-level workers and district managers.

    PubMed

    Fonn, Sharon; Ray, Sunanda; Blaauw, Duane

    2011-01-01

    Initiatives to address the human resource crisis in African health systems have included expanded training of mid-level workers (MLWs). Currently, MLWs are the backbone of many health systems in Africa but they are often de-motivated and they often operate in circumstances in which providing high quality care is challenging. Therefore, assuming that introducing additional people will materially change health system performance is unrealistic. We briefly critique such unifocal interventions and review the literature to understand the factors that affect the motivation and performance of MLWs. Three themes emerge: the low status and inadequate recognition of MLWs, quality of care issues and working in poorly managed systems. In response we propose three interrelated interventions: a regional association of MLWs to enhance their status and recognition, a job enrichment and mentoring system to address quality and a district managers' association to improve health systems management. The professionalisation of MLWs and district managers to address confidence, self-esteem and value is considered. The paper describes the thinking behind these interventions, which are currently being tested in Kenya, Nigeria, South Africa and Uganda for their acceptability and appropriateness. We offer the policy community a complementary repertoire to existing human resource strategies in order to effect real change in African health systems.

  15. Management Information System

    NASA Technical Reports Server (NTRS)

    1984-01-01

    New Automated Management Information Center (AMIC) employs innovative microcomputer techniques to create color charts, viewgraphs, or other data displays in a fraction of the time formerly required. Developed under Kennedy Space Center's contract by Boeing Services International Inc., Seattle, WA, AMIC can produce an entirely new informational chart in 30 minutes, or an updated chart in only five minutes. AMIC also has considerable potential as a management system for business firms.

  16. Power system

    DOEpatents

    Hickam, Christopher Dale

    2008-03-18

    A power system includes a prime mover, a transmission, and a fluid coupler having a selectively engageable lockup clutch. The fluid coupler may be drivingly connected between the prime mover and the transmission. Additionally, the power system may include a motor/generator drivingly connected to at least one of the prime mover and the transmission. The power-system may also include power-system controls configured to execute a control method. The control method may include selecting one of a plurality of modes of operation of the power system. Additionally, the control method may include controlling the operating state of the lockup clutch dependent upon the mode of operation selected. The control method may also include controlling the operating state of the motor/generator dependent upon the mode of operation selected.

  17. Innovators.

    ERIC Educational Resources Information Center

    NEA Today, 2001

    2001-01-01

    Describes various innovations that have been developed to enhance education. These innovations include: helping educators help at-risk students succeed; promoting high school journalism; ensuring quality online learning experiences; developing a student performing group that uses theater to address social issues; and having students design their…

  18. Saturn Systems.

    PubMed

    U Rehman, Habib; McKee, Nida A; McKee, Michael L

    2016-01-15

    Several ring systems (Saturn systems) have been studied using DFT methods that include dispersion effects. Comparison with X-ray structures are made with three systems, and the agreement is quite good. Binding enthalpies and binding free energies in dichloromethane and toluene have been computed. The effect of an encapsulated lithium cation is accessed by comparing C60 @(C6 H4 )10 and [Li@C60 @(C6 H4 )10 ](+). The [Li@C60 ](+) cation is a much better acceptor than C60 which leads to greater donor-acceptor interactions and larger charge transfer from the ring to [Li@C60 ](+).

  19. Saturn Systems.

    PubMed

    U Rehman, Habib; McKee, Nida A; McKee, Michael L

    2016-01-15

    Several ring systems (Saturn systems) have been studied using DFT methods that include dispersion effects. Comparison with X-ray structures are made with three systems, and the agreement is quite good. Binding enthalpies and binding free energies in dichloromethane and toluene have been computed. The effect of an encapsulated lithium cation is accessed by comparing C60 @(C6 H4 )10 and [Li@C60 @(C6 H4 )10 ](+). The [Li@C60 ](+) cation is a much better acceptor than C60 which leads to greater donor-acceptor interactions and larger charge transfer from the ring to [Li@C60 ](+). PMID:26096724

  20. Electronic system

    DOEpatents

    Robison, G H; Dickson, J F

    1960-11-15

    An electronic system is designed for indicating the occurrence of a plurality of electrically detectable events within predetermined time intervals. The system comprises separate input means electrically associated with the events under observation an electronic channel associated with each input means, including control means and indicating means; timing means adapted to apply a signal from the input means after a predetermined time to the control means to deactivate each of the channels; and means for resetting the system to its initial condition after the observation of each group of events. (D.L.C.)

  1. Robotic Waterjet System

    NASA Technical Reports Server (NTRS)

    1996-01-01

    NASA needed a way to safely strip old paint and thermal protection material from reusable components from the Space Shuttle; to meet this requirement, Marshall Space Flight Center teamed with United Technologies' USBI Company and developed a stripping system based on hydroblasting. United Technology spun off a new company, Waterjet Systems, to commercialize and market the technology. The resulting ARMS (Automated Robotic Maintenance Systems), employ waterblasts at 55,000 pounds per square inch controlled by target-sensitive robots. The systems are used on aircraft and engine parts, and the newest application is on ships, where it not only strips but catches the ensuing wastewater. This innovation results in faster, cheaper stripping with less clean-up and reduced environmental impact.

  2. SAMPLING SYSTEM

    DOEpatents

    Hannaford, B.A.; Rosenberg, R.; Segaser, C.L.; Terry, C.L.

    1961-01-17

    An apparatus is given for the batch sampling of radioactive liquids such as slurries from a system by remote control, while providing shielding for protection of operating personnel from the harmful effects of radiation.

  3. Systems Analysis.

    ERIC Educational Resources Information Center

    Loucks, D. P.; Bell, J. M.

    1978-01-01

    Presents a literature review of the analysis of the administrative systems of various environmental programs related to water quality and pollution policy. A list of 70 references published in 1976 and 1977 is also presented. (HM)

  4. Microelectromechanical Systems

    NASA Technical Reports Server (NTRS)

    Gabriel, Kaigham J.

    1995-01-01

    Micro-electromechanical systems (MEMS) is an enabling technology that merges computation and communication with sensing and actuation to change the way people and machines interact with the physical world. MEMS is a manufacturing technology that will impact widespread applications including: miniature inertial measurement measurement units for competent munitions and personal navigation; distributed unattended sensors; mass data storage devices; miniature analytical instruments; embedded pressure sensors; non-invasive biomedical sensors; fiber-optics components and networks; distributed aerodynamic control; and on-demand structural strength. The long term goal of ARPA's MEMS program is to merge information processing with sensing and actuation to realize new systems and strategies for both perceiving and controlling systems, processes, and the environment. The MEMS program has three major thrusts: advanced devices and processes, system design, and infrastructure.

  5. Recommender systems

    NASA Astrophysics Data System (ADS)

    Lü, Linyuan; Medo, Matúš; Yeung, Chi Ho; Zhang, Yi-Cheng; Zhang, Zi-Ke; Zhou, Tao

    2012-10-01

    The ongoing rapid expansion of the Internet greatly increases the necessity of effective recommender systems for filtering the abundant information. Extensive research for recommender systems is conducted by a broad range of communities including social and computer scientists, physicists, and interdisciplinary researchers. Despite substantial theoretical and practical achievements, unification and comparison of different approaches are lacking, which impedes further advances. In this article, we review recent developments in recommender systems and discuss the major challenges. We compare and evaluate available algorithms and examine their roles in the future developments. In addition to algorithms, physical aspects are described to illustrate macroscopic behavior of recommender systems. Potential impacts and future directions are discussed. We emphasize that recommendation has great scientific depth and combines diverse research fields which makes it interesting for physicists as well as interdisciplinary researchers.

  6. Respiratory system

    NASA Technical Reports Server (NTRS)

    Bartlett, R. G., Jr.

    1973-01-01

    The general anatomy and function of the human respiratory system is summarized. Breathing movements, control of breathing, lung volumes and capacities, mechanical relations, and factors relevant to respiratory support and equipment design are discussed.

  7. Laser Systems

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Tunable diode lasers are employed as radiation sources in high resolution infrared spectroscopy to determine spectral characteristics of gaseous compounds. With other laser systems, they are produced by Spectra-Physics, and used to monitor chemical processes, monitor production of quantity halogen lamps, etc. The Laser Analytics Division of Spectra-Physics credits the system's reliability to a program funded by Langley in the 1970s. Company no longer U.S.-owned. 5/22/97

  8. Systems and Components Fuel Delivery System, Water Delivery System, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Systems and Components - Fuel Delivery System, Water Delivery System, Derrick Crane System, and Crane System Details - Marshall Space Flight Center, F-1 Engine Static Test Stand, On Route 565 between Huntsville and Decatur, Huntsville, Madison County, AL

  9. Chaotic Systems

    NASA Astrophysics Data System (ADS)

    Myasishchev, Denis; Bixler, David

    2009-04-01

    Chaos theory is a current topic in physics research and is of great scientific and applied interest. Chaotic systems include weather patterns, genetic evolution and free market economics. Modeling chaotic phenomena using electronic circuits is a convenient way to analyze nonlinear systems. We have built various types of circuits and examined the conditions under which chaos occurs. Chua's circuit and analog computing circuits (ones that directly model systems of differential equations) were in the spotlight during the fall semester. An R-C phase space diagram for the Chua's circuit was constructed and the phase transitions were examined. Different analog computing circuits were built and the resulting attractors, attractor phases, and bifurcations were recorded. A mechanical system, the two block train model, is the current focus of study. The goal is to examine attractors produced by a mechanical system, a computer simulation, and a corresponding circuit in order to prove that the same experimental results can be obtained from different sources. This way if a mechanical system is too complicated to build, it can be substituted by a suitable circuit.

  10. Plant Phenotype Characterization System

    SciTech Connect

    Daniel W McDonald; Ronald B Michaels

    2005-09-09

    This report is the final scientific report for the DOE Inventions and Innovations Project: Plant Phenotype Characterization System, DE-FG36-04GO14334. The period of performance was September 30, 2004 through July 15, 2005. The project objective is to demonstrate the viability of a new scientific instrument concept for the study of plant root systems. The root systems of plants are thought to be important in plant yield and thus important to DOE goals in renewable energy sources. The scientific study and understanding of plant root systems is hampered by the difficulty in observing root activity and the inadequacy of existing root study instrumentation options. We have demonstrated a high throughput, non-invasive, high resolution technique for visualizing plant root systems in-situ. Our approach is based upon low-energy x-ray radiography and the use of containers and substrates (artificial soil) which are virtually transparent to x-rays. The system allows us to germinate and grow plant specimens in our containers and substrates and to generate x-ray images of the developing root system over time. The same plant can be imaged at different times in its development. The system can be used for root studies in plant physiology, plant morphology, plant breeding, plant functional genomics and plant genotype screening.

  11. Systems Biology for Smart Crops and Agricultural Innovation: Filling the Gaps between Genotype and Phenotype for Complex Traits Linked with Robust Agricultural Productivity and Sustainability

    PubMed Central

    Pathak, Rajesh Kumar; Gupta, Sanjay Mohan; Gaur, Vikram Singh; Pandey, Dinesh

    2015-01-01

    Abstract In recent years, rapid developments in several omics platforms and next generation sequencing technology have generated a huge amount of biological data about plants. Systems biology aims to develop and use well-organized and efficient algorithms, data structure, visualization, and communication tools for the integration of these biological data with the goal of computational modeling and simulation. It studies crop plant systems by systematically perturbing them, checking the gene, protein, and informational pathway responses; integrating these data; and finally, formulating mathematical models that describe the structure of system and its response to individual perturbations. Consequently, systems biology approaches, such as integrative and predictive ones, hold immense potential in understanding of molecular mechanism of agriculturally important complex traits linked to agricultural productivity. This has led to identification of some key genes and proteins involved in networks of pathways involved in input use efficiency, biotic and abiotic stress resistance, photosynthesis efficiency, root, stem and leaf architecture, and nutrient mobilization. The developments in the above fields have made it possible to design smart crops with superior agronomic traits through genetic manipulation of key candidate genes. PMID:26484978

  12. Systems Biology for Smart Crops and Agricultural Innovation: Filling the Gaps between Genotype and Phenotype for Complex Traits Linked with Robust Agricultural Productivity and Sustainability.

    PubMed

    Kumar, Anil; Pathak, Rajesh Kumar; Gupta, Sanjay Mohan; Gaur, Vikram Singh; Pandey, Dinesh

    2015-10-01

    In recent years, rapid developments in several omics platforms and next generation sequencing technology have generated a huge amount of biological data about plants. Systems biology aims to develop and use well-organized and efficient algorithms, data structure, visualization, and communication tools for the integration of these biological data with the goal of computational modeling and simulation. It studies crop plant systems by systematically perturbing them, checking the gene, protein, and informational pathway responses; integrating these data; and finally, formulating mathematical models that describe the structure of system and its response to individual perturbations. Consequently, systems biology approaches, such as integrative and predictive ones, hold immense potential in understanding of molecular mechanism of agriculturally important complex traits linked to agricultural productivity. This has led to identification of some key genes and proteins involved in networks of pathways involved in input use efficiency, biotic and abiotic stress resistance, photosynthesis efficiency, root, stem and leaf architecture, and nutrient mobilization. The developments in the above fields have made it possible to design smart crops with superior agronomic traits through genetic manipulation of key candidate genes.

  13. Systems Biology for Smart Crops and Agricultural Innovation: Filling the Gaps between Genotype and Phenotype for Complex Traits Linked with Robust Agricultural Productivity and Sustainability.

    PubMed

    Kumar, Anil; Pathak, Rajesh Kumar; Gupta, Sanjay Mohan; Gaur, Vikram Singh; Pandey, Dinesh

    2015-10-01

    In recent years, rapid developments in several omics platforms and next generation sequencing technology have generated a huge amount of biological data about plants. Systems biology aims to develop and use well-organized and efficient algorithms, data structure, visualization, and communication tools for the integration of these biological data with the goal of computational modeling and simulation. It studies crop plant systems by systematically perturbing them, checking the gene, protein, and informational pathway responses; integrating these data; and finally, formulating mathematical models that describe the structure of system and its response to individual perturbations. Consequently, systems biology approaches, such as integrative and predictive ones, hold immense potential in understanding of molecular mechanism of agriculturally important complex traits linked to agricultural productivity. This has led to identification of some key genes and proteins involved in networks of pathways involved in input use efficiency, biotic and abiotic stress resistance, photosynthesis efficiency, root, stem and leaf architecture, and nutrient mobilization. The developments in the above fields have made it possible to design smart crops with superior agronomic traits through genetic manipulation of key candidate genes. PMID:26484978

  14. Multipurpose Hyperspectral Imaging System

    NASA Technical Reports Server (NTRS)

    Mao, Chengye; Smith, David; Lanoue, Mark A.; Poole, Gavin H.; Heitschmidt, Jerry; Martinez, Luis; Windham, William A.; Lawrence, Kurt C.; Park, Bosoon

    2005-01-01

    A hyperspectral imaging system of high spectral and spatial resolution that incorporates several innovative features has been developed to incorporate a focal plane scanner (U.S. Patent 6,166,373). This feature enables the system to be used for both airborne/spaceborne and laboratory hyperspectral imaging with or without relative movement of the imaging system, and it can be used to scan a target of any size as long as the target can be imaged at the focal plane; for example, automated inspection of food items and identification of single-celled organisms. The spectral resolution of this system is greater than that of prior terrestrial multispectral imaging systems. Moreover, unlike prior high-spectral resolution airborne and spaceborne hyperspectral imaging systems, this system does not rely on relative movement of the target and the imaging system to sweep an imaging line across a scene. This compact system (see figure) consists of a front objective mounted at a translation stage with a motorized actuator, and a line-slit imaging spectrograph mounted within a rotary assembly with a rear adaptor to a charged-coupled-device (CCD) camera. Push-broom scanning is carried out by the motorized actuator which can be controlled either manually by an operator or automatically by a computer to drive the line-slit across an image at a focal plane of the front objective. To reduce the cost, the system has been designed to integrate as many as possible off-the-shelf components including the CCD camera and spectrograph. The system has achieved high spectral and spatial resolutions by using a high-quality CCD camera, spectrograph, and front objective lens. Fixtures for attachment of the system to a microscope (U.S. Patent 6,495,818 B1) make it possible to acquire multispectral images of single cells and other microscopic objects.

  15. Designing and Implementing an Innovative SMS-based alert system (RapidSMS-MCH) to monitor pregnancy and reduce maternal and child deaths in Rwanda

    PubMed Central

    Ngabo, Fidele; Nguimfack, Judith; Nwaigwe, Friday; Mugeni, Catherine; Muhoza, Denis; Wilson, David R; Kalach, John; Gakuba, Richard; Karema, Corrine; Binagwaho, Agnes

    2012-01-01

    Introduction With the continuous growth of mobile network coverage and unprecedented penetration of mobile devices in the developing world, several mHealth initiatives are being implemented in developing countries. This paper aims to describe requirements for designing and implementing a mobile phone-based communication system aiming at monitoring pregnancy and reducing bottlenecks in communication associated with maternal and newborn deaths; and document challenges and lessons learned. Methods An SMS-based system was developed to improve maternal and child health (MCH) using RapidSMS®, a free and open-sourced software development framework. To achieve the expected results, the RapidSMS-MCH system was customized to allow interactive communication between a community health worker (CHW)following mother-infant pairs in their community, a national centralized database, the health facility and in case of an emergency alert, the ambulance driver. The RapidSMS-MCH system was piloted in Musanze district, Nothern province of Rwanda over a 12-month period. Results A total of 432 CHW were trained and equipped with mobile phones. A total of 35,734 SMS were sent by 432 CHW from May 2010 to April 2011. A total of 11,502 pregnancies were monitored. A total of 362 SMS alerts for urgent and life threatening events were registered. We registered a 27% increase in facility based delivery from 72% twelve months before to 92% at the end of the twelve months pilot phase. Major challenges were telephone maintenance and replacement. Disctrict heath team capacity to manage and supervise the system was strengthened by the end of pilot phase. Highly committed CHWs and effective coordination by the District health team were critical enablers. Conclusion We successully designed and implemented a mobile phone SMS-based system to track pregnancy and maternal and child outcomes in limited resources setting. Implementation of mobile-phone systems at community level could contribute to improving

  16. Systems Studies

    SciTech Connect

    Graham, R.L.

    1998-03-17

    The Systems Studies Activity had two objectives: (1) to investigate nontechnical barriers to the deployment of biomass production and supply systems and (2) to enhance and extend existing systems models of bioenergy supply and use. For the first objective, the Activity focused on existing bioenergy markets. Four projects were undertaken: a comparative analysis of bioenergy in Sweden and Austria; a one-day workshop on nontechnical barriers jointly supported by the Production Systems Activity; the development and testing of a framework for analyzing barriers and drivers to bioenergy markets; and surveys of wood pellet users in Sweden, Austria and the US. For the second objective, two projects were undertaken. First, the Activity worked with the Integrated BioEnergy Systems (TBS) Activity of TEA Bioenergy Task XIII to enhance the BioEnergy Assessment Model (BEAM). This model is documented in the final report of the IBS Activity. The Systems Studies Activity contributed to enhancing the feedstock portion of the model by developing a coherent set of willow, poplar, and switchgrass production modules relevant to both the US and the UK. The Activity also developed a pretreatment module for switchgrass. Second, the Activity sponsored a three-day workshop on modeling bioenergy systems with the objectives of providing an overview of the types of models used to evaluate bioenergy and promoting communication among bioenergy modelers. There were nine guest speakers addressing different types of models used to evaluate different aspects of bioenergy, ranging from technoeconomic models based on the ASPEN software to linear programming models to develop feedstock supply curves for the US. The papers from this workshop have been submitted to Biomass and Bioenergy and are under editorial review.

  17. Systemic fluoride.

    PubMed

    Sampaio, Fábio Correia; Levy, Steven Marc

    2011-01-01

    There is substantial evidence that fluoride, through different applications and formulas, works to control caries development. The first observations of fluoride's effects on dental caries were linked to fluoride naturally present in the drinking water, and then from controlled water fluoridation programs. Other systemic methods to deliver fluoride were later suggested, including dietary fluoride supplements such as salt and milk. These systemic methods are now being questioned due to the fact that many studies have indicated that fluoride's action relies mainly on its post-eruptive effect from topical contact with the tooth structure. It is known that even the methods of delivering fluoride known as 'systemic' act mainly through a topical effect when they are in contact with the teeth. The effectiveness of water fluoridation in many geographic areas is lower than in previous eras due to the widespread use of other fluoride modalities. Nevertheless, this evidence should not be interpreted as an indication that systemic methods are no longer relevant ways to deliver fluoride on an individual basis or for collective health programs. Caution must be taken to avoid excess ingestion of fluoride when prescribing dietary fluoride supplements for children in order to minimize the risk of dental fluorosis, particularly if there are other relevant sources of fluoride intake - such as drinking water, salt or milk and/or dentifrice. Safe and effective doses of fluoride can be achieved when combining topical and systemic methods.

  18. Systemic trauma.

    PubMed

    Goldsmith, Rachel E; Martin, Christina Gamache; Smith, Carly Parnitzke

    2014-01-01

    Substantial theoretical, empirical, and clinical work examines trauma as it relates to individual victims and perpetrators. As trauma professionals, it is necessary to acknowledge facets of institutions, cultures, and communities that contribute to trauma and subsequent outcomes. Systemic trauma-contextual features of environments and institutions that give rise to trauma, maintain it, and impact posttraumatic responses-provides a framework for considering the full range of traumatic phenomena. The current issue of the Journal of Trauma & Dissociation is composed of articles that incorporate systemic approaches to trauma. This perspective extends conceptualizations of trauma to consider the influence of environments such as schools and universities, churches and other religious institutions, the military, workplace settings, hospitals, jails, and prisons; agencies and systems such as police, foster care, immigration, federal assistance, disaster management, and the media; conflicts involving war, torture, terrorism, and refugees; dynamics of racism, sexism, discrimination, bullying, and homophobia; and issues pertaining to conceptualizations, measurement, methodology, teaching, and intervention. Although it may be challenging to expand psychological and psychiatric paradigms of trauma, a systemic trauma perspective is necessary on both scientific and ethical grounds. Furthermore, a systemic trauma perspective reflects current approaches in the fields of global health, nursing, social work, and human rights. Empirical investigations and intervention science informed by this paradigm have the potential to advance scientific inquiry, lower the incidence of a broader range of traumatic experiences, and help to alleviate personal and societal suffering.

  19. Systemic trauma.

    PubMed

    Goldsmith, Rachel E; Martin, Christina Gamache; Smith, Carly Parnitzke

    2014-01-01

    Substantial theoretical, empirical, and clinical work examines trauma as it relates to individual victims and perpetrators. As trauma professionals, it is necessary to acknowledge facets of institutions, cultures, and communities that contribute to trauma and subsequent outcomes. Systemic trauma-contextual features of environments and institutions that give rise to trauma, maintain it, and impact posttraumatic responses-provides a framework for considering the full range of traumatic phenomena. The current issue of the Journal of Trauma & Dissociation is composed of articles that incorporate systemic approaches to trauma. This perspective extends conceptualizations of trauma to consider the influence of environments such as schools and universities, churches and other religious institutions, the military, workplace settings, hospitals, jails, and prisons; agencies and systems such as police, foster care, immigration, federal assistance, disaster management, and the media; conflicts involving war, torture, terrorism, and refugees; dynamics of racism, sexism, discrimination, bullying, and homophobia; and issues pertaining to conceptualizations, measurement, methodology, teaching, and intervention. Although it may be challenging to expand psychological and psychiatric paradigms of trauma, a systemic trauma perspective is necessary on both scientific and ethical grounds. Furthermore, a systemic trauma perspective reflects current approaches in the fields of global health, nursing, social work, and human rights. Empirical investigations and intervention science informed by this paradigm have the potential to advance scientific inquiry, lower the incidence of a broader range of traumatic experiences, and help to alleviate personal and societal suffering. PMID:24617751

  20. Systemic fluoride.

    PubMed

    Sampaio, Fábio Correia; Levy, Steven Marc

    2011-01-01

    There is substantial evidence that fluoride, through different applications and formulas, works to control caries development. The first observations of fluoride's effects on dental caries were linked to fluoride naturally present in the drinking water, and then from controlled water fluoridation programs. Other systemic methods to deliver fluoride were later suggested, including dietary fluoride supplements such as salt and milk. These systemic methods are now being questioned due to the fact that many studies have indicated that fluoride's action relies mainly on its post-eruptive effect from topical contact with the tooth structure. It is known that even the methods of delivering fluoride known as 'systemic' act mainly through a topical effect when they are in contact with the teeth. The effectiveness of water fluoridation in many geographic areas is lower than in previous eras due to the widespread use of other fluoride modalities. Nevertheless, this evidence should not be interpreted as an indication that systemic methods are no longer relevant ways to deliver fluoride on an individual basis or for collective health programs. Caution must be taken to avoid excess ingestion of fluoride when prescribing dietary fluoride supplements for children in order to minimize the risk of dental fluorosis, particularly if there are other relevant sources of fluoride intake - such as drinking water, salt or milk and/or dentifrice. Safe and effective doses of fluoride can be achieved when combining topical and systemic methods. PMID:21701196