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Sample records for instrument voor het

  1. Softwaremodule voor het Simuleren van de Gevolgen van Raketonderschepping (The Dutch Program for the Simulation of Missile Intercept Effects)

    DTIC Science & Technology

    2007-07-01

    exernplaar van het rapport. 1 DMO/SC-DR&D standaard inclusief digitale versie bijgeleverd op cd-romn 2/3 DMO/DR&D/Kennistransfer 4 DM0/ Directie Beleid...MPH 10 CDC/BGGZ/CEMG A.S. de Koning. arts standaard inclusief digitale versie bijgeleverd op cd-rom 11/12 DMIVD, Kabinet 13 Militaire Inlichtingen- en...Veiligheidsdienst Drs. E. Buijs 14 BS/DS/DOBBP/B Maj B. Doesburg-Smits 15 CJKC NBC, Ltkol C.A. Bourgondi n standaard inclusief digitale versie

  2. Storings analyse Ten Behoeve van het Materieelverzorgingsplan (Failure Analysis for the Maintenance Plan)

    DTIC Science & Technology

    1990-05-01

    van kwantitatieve normen voor logistieke parameters, op grond waarvan de logistieke ondersteuning ontworpen moet worden. Binnen ILS wordt de logistieke...ondersteuning zodanig ingericht dat aan van tevoren vastgestelde kwantitatieve normen voor bescbikbaarheid, inzetbaarheid, betrouwbaarbeid en...9] ’Richtlijnen ten aanzien van het materieelverzorgingsplan’. Deze docuinenten geven de uitgangspunten en normen die de opsteller in acht moet nemen

  3. Eisen voor Buitenbeelden van Voertuigsimulatoren: Een Literatuurstudie (Use of Exterior Pictures in Vehicle Simulators: A Literature Survey)

    DTIC Science & Technology

    1991-06-01

    afstand van bet traject van bet voertuig (Waidram, 1985), zoals onderbroken wegbelijning of bomen langs, de weg. Voor bet waarnemen van koers en...betroffen het op constante boogte houden en een vaste koers bandbaven bij random verstoringen. Een beeldvertraging van 100 ms zou ook geen belangrijk effect...Voor onderzoek naar, en training van, interacties tussen weggebmuikers is het echter belangrijk omn zowel koers als sneiheid van U6n of meer

  4. KIBOWI: A Training Wargame for the Royal Netherlands Army (KIBOWI: Een Training Wargame voor de Koninklijke Landmacht)

    DTIC Science & Technology

    1989-12-01

    gebruik van het model heeft plaatsgevonden gedurende 1988 en 1989 voor circa 20 weken op bataljonsniveau. Ervaring in het gebruik van het prototype...representatie en eenheidsinteractie (detectie, direct vuur, etc.). TNO report Page 4 CONTENTS ABSTRACT 1 SAMENVATTING 2 CONTENTS 4 1 INTRODUCTION 6 2 THE...processes, readjusting for hardware failures, making backups, restarts, etc. 2. Database manager To create exercise databases and to facilitate and

  5. Flitseenheid voor Ultra Snelle Fotografie (Flash Unit for High-Speed Photography)

    DTIC Science & Technology

    1992-09-01

    fotografie PML 1992-91 september 1992 Exemplaar no:- 10 Autmir(s): M. Koops T. Huijser Tow]aaiantal paginars: (oxcd. distr. Iijsl on RIDPj 50 Aantai...beschrijft de ontwikkeling van een hoog energetische gepulste lichthron ten behoeve an de ultra snelle fotografie . De gebouwde flitseenheid bestaat uit een... fotografie is een zeer geschikre diagnostische techrnek voor het vastleggen van snelle verschijnselen zoals die zich o.a. voordoen op het werkgebied

  6. Het natuurwetenschappelijk modelleren van dynamische systemen; Naar een didactiek voor het voortgezet onderwijs

    NASA Astrophysics Data System (ADS)

    Ormel, B. J. B.

    2010-01-01

    Scientific modelling of dynamical systems; towards a pedagogy for secondary education Computer models of complex dynamical systems play a major role in science, as well as in societal debate about issues such as climate change, and insight in models and modelling is an important learning aim in science education. However, in teaching practice, it has proven difficult to give computer modelling an integrated role in the curriculum. We took a design research approach to gain insight in the pedagogy of modelling complex dynamical systems. We designed a physics course in which students constructed, evaluated and refined computer models of the climate system. Our design objectives were to get the students engaged in a meaningful modelling process, while retaining essential characteristics of the scientific modelling process. The teaching design was classroom-tested with four teachers and, after being revised, again with one teacher. The overall conclusion is that, although the models become more and more complex along the way, the content and level of the module are well within the range of pupils’ capacities. However, the evaluation of both research cycles revealed some critical problems that hindered the achievement of the teaching goals. Based on what seemed feasible as well as problematic we formulated guidelines for the designing of a modelling curriculum. It is important that modules geared at gaining authentic modelling experience only follow after the teaching of relevant and necessary content knowledge. Focussing on the scientific modelling process should not be combined with substantive content goals. Teaching the paradigmatic models of a domain may be a powerful tool to enable pupils to apply their knowledge in a variety of contexts. Developing these models and teaching pupils how to use them then coincides with teaching the regular physics concepts. We found that students find it difficult to explain behaviour in terms of ‘rules of change’. Therefore, we propose that teaching dynamics focuses on describing the rules of change in terms of differential equations, even for rather simple systems that can be described analytically. Next, we touched upon the delicate balance between guidance and freedom. While some guidance is needed to provide a sense of direction, too much guidance may also hinder insightfulness. In a directive approach in which the teacher shows an expert modelling process, pupils may develop advanced models. However, their own ideas about the system and about how to approach the problem remain unknown. In a pupil-oriented approach it is easy to underestimate the need for explicitly motivating model decisions by the pupils as well as those made by the teacher, in order to establish a truly purpose-driven process. In our tests, teachers were little inclined to let the students evaluate their own contributions, and the students were not used to it either. Thus, if students are to become independent modellers, this will affect the whole classroom culture. Also, experiencing the modelling cycle repeatedly does not guarantee that pupils become more independent modellers themselves. They would benefit from systematic reflection on modelling activities which specifies clearly what each activity should yield and how these yields are achieved.

  7. TNO Contribution to the Quest 303 Trial - Human Performance Assessed by a Vigilance and Tracking Test, a Multi-Attribute Task, and by Dynamic Visual Acuity (TNO Bijdrage aan het Quest 303 Onderzoek)

    DTIC Science & Technology

    2008-07-01

    TNO Report TI Knweg for. siesIN Nederlandse Organisatie voor toegepast-natuurwetenschappelijk TNO Defence, Security and Safety fo ple cetfcRsac...objectieve maten voor taakprestatie te verzamelen onder invloed van echte scheepsbewegingen. In opdracht van de Nederlandse marine heeft TNO aan dit...rapport wordt het protocol beschreven, de bewegingscondities, en de resultaten van de Nederlandse tests. De resultaten laten zien dat cognitief

  8. The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

    PubMed Central

    Seuring, Carolin; Greenwald, Jason; Wasmer, Christian; Wepf, Roger; Saupe, Sven J.; Meier, Beat H.; Riek, Roland

    2012-01-01

    The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility. This reaction is observed at the point of contact between two genetically distinct strains when one harbors a HET-s prion (in the form of amyloid aggregates) and the other expresses a soluble HET-S protein (96% identical to HET-s). How the HET-s prion interaction with HET-S brings about cell death remains unknown; however, it was recently shown that this interaction leads to a relocalization of HET-S from the cytoplasm to the cell periphery and that this change is associated with cell death. Here, we present detailed insights into this mechanism in which a non-toxic HET-s prion converts a soluble HET-S protein into an integral membrane protein that destabilizes membranes. We observed liposomal membrane defects of approximately 10 up to 60 nm in size in transmission electron microscopy images of freeze-fractured proteoliposomes that were formed in mixtures of HET-S and HET-s amyloids. In liposome leakage assays, HET-S has an innate ability to associate with and disrupt lipid membranes and that this activity is greatly enhanced when HET-S is exposed to HET-s amyloids. Solid-state nuclear magnetic resonance (NMR) analyses revealed that HET-s induces the prion-forming domain of HET-S to adopt the β-solenoid fold (previously observed in HET-s) and this change disrupts the globular HeLo domain. These data indicate that upon interaction with a HET-s prion, the HET-S HeLo domain partially unfolds, thereby exposing a previously buried ∼34-residue N-terminal transmembrane segment. The liberation of this segment targets HET-S to the membrane where it further oligomerizes, leading to a loss of membrane integrity. HET-S thus appears to display features that are reminiscent of pore-forming toxins. PMID:23300377

  9. Boltzmann Transport in Hybrid PIC HET Modeling

    DTIC Science & Technology

    2015-07-01

    the device. Experimental measurements and computational simulations have consistently indicated that the electron transport perpendicular to the...plasma conditions experienced in HPHall. 1. Electron mobility in HET simulation The most widely used computational simulations of HETs, including HPHall...Figure 1: Cartoon schematic of anomalous electron trans- port regions in typical HET II. Computational setup As the stalwart HET simulation code in the EP

  10. The Impact of Collision Avoidance Systems on Driver Behavior and Traffic Safety: Preliminaries to Studies within the ’Gids’ Project (Het Effect van anti- bots systemen op bestuurdersgedrag en op de verkeersveiligheid)

    DTIC Science & Technology

    1989-11-23

    ELECTE N FEB 20 1990 D Number of pages: 23 DI3TRmIm. oN sn~!TmrNT A ApProved fei p rhc release Lisuibuuan Uui~ited ’U, 3 CONTENTS Page SUMMARY 5... CONTENT AND ALLOCATION OF EVASIVE ACTIONS 14 4.1 Displaying the relevant variable 15 4.2 Warnings 15 4.3 Suggestions and active controls 15 4.4 Total...beantwoord inoeten warden willen anti-bats systemen zinnig geacht kunnen warden: (1) Wat moet het criteriun zijn voor activatie van het systeem ? (2

  11. HetF and PatA control levels of HetR in Anabaena sp. strain PCC 7120.

    PubMed

    Risser, Douglas D; Callahan, Sean M

    2008-12-01

    Anabaena sp. strain PCC 7120 is a filamentous cyanobacterium that differentiates heterocysts in response to deprivation of combined nitrogen. A hetF deletion strain lacked heterocysts and had aberrant cell morphology. Site-directed mutagenesis of the predicted active-site histidine and cysteine residues of this putative caspase-hemoglobinase fold protease abolished HetF function, supporting the hypothesis that HetF is a protease. Deletion of patA, which is necessary for the formation of most intercalary heterocysts, or hetF resulted in an increase in HetR protein, and extra copies of hetF on a plasmid functionally bypassed the deletion of patA. A hetR-gfp translational fusion expressed from an inducible promoter demonstrated that hetF-dependent downregulation of HetR levels occurs rapidly in vegetative cells, as well as developing heterocysts. "Mosaic" filaments in which only one cell of a filament had a copy of hetR or hetF indicated that hetF is required for differentiation only in cells that will become heterocysts. hetF was required for transcription from a hetR-dependent transcription start point of the hetR promoter and induction of transcription from the patS promoter. The inverse correlation between the level of HetR protein and transcription from hetR-dependent promoters suggests that the transcriptional activity of HetR is regulated by HetF and PatA.

  12. Hetdex: Virus Instrument

    NASA Astrophysics Data System (ADS)

    Lee, Hanshin; Hill, G. J.; DePoy, D. L.; Tuttle, S.; Marshall, J. L.; Vattiat, B. L.; Prochaska, T.; Chonis, T. S.; Allen, R.; HETDEX Collaboration

    2012-01-01

    The Visible Integral-field-unit Replicable Unit Spectrograph (VIRUS) instrument is made up of 150+ individually compact and identical spectrographs, each fed by a fiber integral-field unit. The instrument provides integral field spectroscopy at wavelengths between 350nm and 550nm of over 33,600 spatial elements per observation, each 1.8 sq. arcsec on the sky, at R 700. The instrument will be fed by a new wide-field corrector (WFC) of the Hobby-Eberly Telescope (HET) with increased science field of view as large as 22arcmin diameter and telescope aperture of 10m. This will enable the HETDEX, a large area blind survey of Lyman-alpha emitting galaxies at redshift z < 3.5. The status of VIRUS instrument construction is summarized.

  13. Op weg naar een didactiek voor natuurkunde-experimenten op afstand : Ontwerp en evaluatie van een via internet uitvoerbaar experiment voor leerlingen uit het voortgezet onderwijs

    NASA Astrophysics Data System (ADS)

    Engelbarts, M. B. A.

    2009-02-01

    The subject of this thesis is a developmental study on “remote experimenting” in education. It concerns the development of a remote experiment that enables pre-university students to carry out a physics experiment at a distance via the internet. Remote experiments can offer several (practical) benefits when compared to conventional experiments but the desire to exploit these benefits put special demands on the design of the experiment, since the students might be conducting the experiment without a teacher in the vicinity. As a consequence of these demands it was decided to focus on exploring the possibilities and problems of remote experiments conducted in the absence of a teacher. The research was carried out in two cycles and focused on the development of a remote experiment that could be conducted autonomously by pre-university students to measure the speed of light in several media. This should answer the global question: What should a technically, as well as didactically, well-functioning remote experiment look like? The first cycle had an explorative character. It showed that technically the experiment already functioned quite well. However, many problems were observed concerning the content, and the way the students were tackling it. This led to two categories of recommendations. Concerning the content, the material should aim at making the students more aware of what they are doing and why they are doing it and several content related problems needed to be avoided. The second category of recommendations concerned the format of the material: the design and the working method. Special attention should be paid to designing a clear structure for the website and adding interaction and control, (feedback- and reflection facilities) to activate the students and guide them through the material. In the second research cycle these recommendations were followed by designing the material within the theoretical framework of the problem posing theory. A didactical structure was designed before writing the actual lesson material for the website describing the inter-related conceptual and content-related motivational pathway of the intended teaching-learning process. The lesson material was set up in such a way that the students are repeatedly confronted with a practical problem to solve and they play an active role in developing the method of measurement. Secondly, in an attempt to compensate for the absence of the teacher and support the teaching-learning process some format elements were developed and deployed like an automated question-, and feedback system that supported the students, activated them and gave them insight into their learning process and a ‘Where-am-I’-window that showed their current position within the material. This all had led to a technically as well as didactically well functioning remote experiment in which, at a global level, the line of reasoning was made explicit and recognizable for the students, and ad a local level was build up out of well connected successive activities and required the students to adopt an active attitude.

  14. As a toxin dies a prion comes to life: A tentative natural history of the [Het-s] prion

    PubMed Central

    Daskalov, Asen; Saupe, Sven J

    2015-01-01

    A variety of signaling pathways, in particular with roles in cell fate and host defense, operate by a prion-like mechanism consisting in the formation of open-ended oligomeric signaling complexes termed signalosomes. This mechanism emerges as a novel paradigm in signal transduction. Among the proteins forming such signaling complexes are the Nod-like receptors (NLR), involved in innate immunity. It now appears that the [Het-s] fungal prion derives from such a cell-fate defining signaling system controlled by a fungal NLR. What was once considered as an isolated oddity turns out to be related to a conserved and widespread signaling mechanism. Herein, we recall the relation of the [Het-s] prion to the signal transduction pathway controlled by the NWD2 Nod-like receptor, leading to activation of the HET-S pore-forming cell death execution protein. We explicit an evolutionary scenario in which formation of the [Het-s] prion is the result of an exaptation process or how a loss-of-function mutation in a pore-forming cell death execution protein (HET-S) has given birth to a functional prion ([Het-s]). PMID:26110610

  15. Origins and Evolution of the HET-s Prion-Forming Protein: Searching for Other Amyloid-Forming Solenoids

    PubMed Central

    Gendoo, Deena M. A.; Harrison, Paul M.

    2011-01-01

    The HET-s prion-forming domain from the filamentous fungus Podospora anserina is gaining considerable interest since it yielded the first well-defined atomic structure of a functional amyloid fibril. This structure has been identified as a left-handed beta solenoid with a triangular hydrophobic core. To delineate the origins of the HET-s prion-forming protein and to discover other amyloid-forming proteins, we searched for all homologs of the HET-s protein in a database of protein domains and fungal genomes, using a combined application of HMM, psi-blast and pGenThreader techniques, and performed a comparative evolutionary analysis of the N-terminal alpha-helical domain and the C-terminal prion-forming domain of HET-s. By assessing the tandem evolution of both domains, we observed that the prion-forming domain is restricted to Sordariomycetes, with a marginal additional sequence homolog in Arthroderma otae as a likely case of horizontal transfer. This suggests innovation and rapid evolution of the solenoid fold in the Sordariomycetes clade. In contrast, the N-terminal domain evolves at a slower rate (in Sordariomycetes) and spans many diverse clades of fungi. We performed a full three-dimensional protein threading analysis on all identified HET-s homologs against the HET-s solenoid fold, and present detailed structural annotations for identified structural homologs to the prion-forming domain. An analysis of the physicochemical characteristics in our set of structural models indicates that the HET-s solenoid shape can be readily adopted in these homologs, but that they are all less optimized for fibril formation than the P. anserina HET-s sequence itself, due chiefly to the presence of fewer asparagine ladders and salt bridges. Our combined structural and evolutionary analysis suggests that the HET-s shape has “limited scope” for amyloidosis across the wider protein universe, compared to the ‘generic’ left-handed beta helix. We discuss the implications of

  16. Testbed Environment for Distributed Observation (testbed omgeving voor gedistribueerde waarneming)

    DTIC Science & Technology

    2006-05-01

    Een voorsiudie die tot de specificaties van het Testbed hebben geleid is heschreven in I Bovendien hevordert een Testhed omigeving, die in meerdere pro...functies loeaal functioneren (bijvoorbeeld pompen inschakelen, ruimtes afsluiten, et cetera) waardoor het systeem onafhankelijk wordt van eon centrale...ongebalanceerde koeling, et cetera) wordt met bebuip van actuatoren (kieppen, cross-overs, pompen , et cetera) bet systeemn gereconfiguroerd zodat de

  17. Upgrade of the HET segment control system, utilizing state-of-the-art, decentralized and embedded system controllers

    NASA Astrophysics Data System (ADS)

    Häuser, Marco; Richter, Josef; Kriel, Herman; Turbyfill, Amanda; Buetow, Brent; Ward, Michael

    2016-07-01

    Together with the ongoing major instrument upgrade of the Hobby-Eberly Telescope (HET) we present the planned upgrade of the HET Segment Control System (SCS) to SCS2. Because HET's primary mirror is segmented into 91 individual 1-meter hexagonal mirrors, the SCS is essential to maintain the mirror alignment throughout an entire night of observations. SCS2 will complete tip, tilt and piston corrections of each mirror segment at a significantly higher rate than the original SCS. The new motion control hardware will further increase the system's reliability. The initial optical measurements of this array are performed by the Mirror Alignment Recovery System (MARS) and the HET Extra Focal Instrument (HEFI). Once the segments are optically aligned, the inductive edge sensors give sub-micron precise feedback of each segment's positions relative to its adjacent segments. These sensors are part of the Segment Alignment Maintenance System (SAMS) and are responsible for providing information about positional changes due to external influences, such as steep temperature changes and mechanical stress, and for making compensatory calculations while tracking the telescope on sky. SCS2 will use the optical alignment systems and SAMS inputs to command corrections of every segment in a closed loop. The correction period will be roughly 30 seconds, mostly due to the measurement and averaging process of the SAMS algorithm. The segment actuators will be controlled by the custom developed HET Segment MOtion COntroller (SMOCO). It is a direct descendant of University Observatory Munich's embedded, CAN-based system and instrument control tool-kit. To preserve the existing HET hardware layout, each SMOCO will control two adjacent mirror segments. Unlike the original SCS motor controllers, SMOCO is able to drive all six axes of its two segments at the same time. SCS2 will continue to allow for sub-arcsecond precision in tip and tilt as well as sub-micro meter precision in piston. These

  18. Buffer Loading and Chunking in Sequential Keypressing (Het Laden van de Motor Buffer Versus Het Gebruik van Motor Chunks bij Sequentieule Toetsdrukseries)

    DTIC Science & Technology

    1994-03-18

    chunking in sequential keypressing (Het laden van de motor buffer versus het gebruik van motor chunks bij sequentiele toetsdrukseries) W.B. Verwey 18 maart...1994, Rapport TM 1994 B-7 TNO Technische Menskunde’, Soesterberg MANAGEMENT UITTREKSEL Dit rapport beschrijft een experiment naar de effecten van...Menakunde. Korte samenvatting van: Buffer loading and chunking in sequential keypressing (Het laden van de motor buffer versus het gebruik van motor

  19. Design, testing, and performance of the Hobby Eberly Telescope prime focus instrument package

    NASA Astrophysics Data System (ADS)

    Vattiat, Brian; Hill, Gary J.; Lee, Hanshin; Perry, Dave M.; Rafal, Marc D.; Rafferty, Tom; Savage, Richard; Taylor, Charles A.; Moreira, Walter; Smith, Michael

    2012-09-01

    The Hobby-Eberly Telescope (HET) is undergoing an upgrade to increase the field of view to 22 arc-minutes with the dark energy survey HETDEX the initial science goal [1]. Here we report on the engineering development of a suite of instruments located at prime focus of the upgraded HET. The Prime Focus Instrument Package (PFIP) contains acquisition, guiding, and wave front sensing instrumentation [2], the fiber feeds for the facility spectrographs (VIRUS, HRS, MRS, LRS2), and ancillary hardware. This paper reviews the design and functions of the PFIP and presents details of the mechanical design, integration and testing.

  20. Cognitie Versus Sensatie: Een Paradigma Voor Herorieentatie (Cognition Versus Sensation: A Paradigm for Reorientation)

    DTIC Science & Technology

    1989-07-01

    EEN PARADIGMA VOOR HERORIWNATIE 2 L.C. Boer 0 DTI ELECTE FEB 16190 WO IDISThMATO .&TfAqMnT A 1 Approved for PWbli reg 90o 02 15 053 Nederiandse...5 39 77eloonr 03463 -5 62 11 IZF 1989-20 ’COGNITIE VERSUS SENSATIE: EEN PARADIGMA VOOR HERORIENTATIE L.C. Boer 20 Niels uid daze ungave mag nworden...Dist I Special 5 Rapport nr.: IZF 1989-20 Titel: Cognitie versus sensatie: eon paradigma voor heroridntatie Auteur: Dr. L.C. Boer Instituut: Instituut

  1. A non Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast

    PubMed Central

    Taneja, Vibha; Maddelein, Marie-Lise; Talarek, Nicolas; J. Saupe, Sven; Liebman, Susan W.

    2007-01-01

    Summary Prions are self-propagating, infectious aggregates of misfolded proteins. The mammalian prion, PrPSc, causes fatal neurodegenerative disorders. Fungi also have prions. While yeast prions depend upon glutamine/asparagine(Q/N)-rich regions, the Podospora anserina HET-s and PrP prion proteins, lack such sequences. Nonetheless, we show that the HET-s prion domain fused to GFP propagates as a prion in yeast. Analogously to native yeast prions: transient overexpression of the HET-s fusion induces ring-like aggregates that propagate in daughter cells as cytoplasmically-inherited, detergent-resistant dot aggregates. Efficient dot propagation, but not ring formation, is dependent upon the Hsp104 chaperone. The yeast prion [PIN+] enhances HET-s ring formation, suggesting that prions with and without Q/N-rich regions interact. Finally, HET-s aggregates propagated in yeast are infectious when introduced into Podospora. To our knowledge, this is the first report of prion propagation in a truly foreign host. Since yeast can host non Q/N-rich prions, such native yeast prions may exist. PMID:17612491

  2. Aeronautic instruments

    NASA Technical Reports Server (NTRS)

    Everling, E; Koppe, H

    1924-01-01

    The development of aeronautic instruments. Vibrations, rapid changes of the conditions of flight and of atmospheric conditions, influence of the air stream all call for particular design and construction of the individual instruments. This is shown by certain examples of individual instruments and of various classes of instruments for measuring pressure, change of altitude, temperature, velocity, inclination and turning or combinations of these.

  3. Mutagenesis of hetR reveals amino acids necessary for HetR function in the heterocystous cyanobacterium Anabaena sp. strain PCC 7120.

    PubMed

    Risser, Douglas D; Callahan, Sean M

    2007-03-01

    HetR is the master regulator of heterocyst differentiation in the filamentous cyanobacterium Anabaena sp. strain PCC 7120. Genetic selection was used to identify 33 amino acid substitutions in HetR that reduced the proportion of cells undergoing heterocyst differentiation to less than 2%. Conservative substitutions in the wild-type HetR protein revealed three mutations that dramatically reduced the amount of heterocyst differentiation when the mutant allele was present in place of the wild-type allele on a replicating plasmid in a mutant lacking hetR on the chromosome. An H69Y substitution resulted in heterocyst formation among less than 0.1% of cells, and D17E and G36A substitutions resulted in a Het- phenotype, compared to heterocyst formation among approximately 25% of cells with the wild-type hetR under the same conditions. The D17E substitution prevented DNA binding activity exhibited by wild-type HetR in mobility shift assays, whereas G36A and H69Y substitutions had no affect on DNA binding. D17E, G36A, and H69Y substitutions also resulted in higher levels of the corresponding HetR protein than of the wild-type protein when each was expressed from an inducible promoter in a hetR deletion strain, suggesting an effect on HetR protein turnover. Surprisingly, C48A and S152A substitutions, which were previously reported to result in a Het- phenotype, were found to have no effect on heterocyst differentiation or patterning when the corresponding mutations were introduced into an otherwise wild-type genetic background in Anabaena sp. strain PCC 7120. The clustering of mutations that satisfied the positive selection near the amino terminus suggests an important role for this part of the protein in HetR function.

  4. [The readers of the Nederlands Tijdschrift voor Geneeskunde].

    PubMed

    Lagerwij, E W

    1993-02-20

    In order to establish the reach, the reading frequency and the appreciation of the Nederlands Tijdschrift voor Geneeskunde, a telephone inquiry was conducted among a random sample of specialists, general practitioners, registrars and pharmacists in the Netherlands. The response amounted to 81.5% (n = 1515). Of the respondents, 94% received the Journal, and two-thirds read it every week. Eight out of ten saved the Journal, five even all volumes. The reading frequency varied greatly from one section to another. Of those who read the Journal at all, 74% always or often read the clinical lesson and 6% the original articles. Although, due to increasing specialization (in width and in depth), it is becoming increasingly difficult to satisfy all readers, the appreciation of the articles is high.

  5. Gyroscopic Instruments for Instrument Flying

    NASA Technical Reports Server (NTRS)

    Brombacher, W G; Trent, W C

    1938-01-01

    The gyroscopic instruments commonly used in instrument flying in the United States are the turn indicator, the directional gyro, the gyromagnetic compass, the gyroscopic horizon, and the automatic pilot. These instruments are described. Performance data and the method of testing in the laboratory are given for the turn indicator, the directional gyro, and the gyroscopic horizon. Apparatus for driving the instruments is discussed.

  6. Fungal prion HET-s as a model for structural complexity and self-propagation in prions.

    PubMed

    Wan, William; Stubbs, Gerald

    2014-04-08

    The highly ordered and reproducible structure of the fungal prion HET-s makes it an excellent model system for studying the inherent properties of prions, self-propagating infectious proteins that have been implicated in a number of fatal diseases. In particular, the HET-s prion-forming domain readily folds into a relatively complex two-rung β-solenoid amyloid. The faithful self-propagation of this fold involves a diverse array of inter- and intramolecular structural features. These features include a long flexible loop connecting the two rungs, buried polar residues, salt bridges, and asparagine ladders. We have used site-directed mutagenesis and X-ray fiber diffraction to probe the relative importance of these features for the formation of β-solenoid structure, as well as the cumulative effects of multiple mutations. Using fibrillization kinetics and chemical stability assays, we have determined the biophysical effects of our mutations on the assembly and stability of the prion-forming domain. We have found that a diversity of structural features provides a level of redundancy that allows robust folding and stability even in the face of significant sequence alterations and suboptimal environmental conditions. Our findings provide fundamental insights into the structural interactions necessary for self-propagation. Propagation of prion structure seems to require an obligatory level of complexity that may not be reproducible in short peptide models.

  7. Fungal prion HET-s as a model for structural complexity and self-propagation in prions

    PubMed Central

    Wan, William; Stubbs, Gerald

    2014-01-01

    The highly ordered and reproducible structure of the fungal prion HET-s makes it an excellent model system for studying the inherent properties of prions, self-propagating infectious proteins that have been implicated in a number of fatal diseases. In particular, the HET-s prion-forming domain readily folds into a relatively complex two-rung β-solenoid amyloid. The faithful self-propagation of this fold involves a diverse array of inter- and intramolecular structural features. These features include a long flexible loop connecting the two rungs, buried polar residues, salt bridges, and asparagine ladders. We have used site-directed mutagenesis and X-ray fiber diffraction to probe the relative importance of these features for the formation of β-solenoid structure, as well as the cumulative effects of multiple mutations. Using fibrillization kinetics and chemical stability assays, we have determined the biophysical effects of our mutations on the assembly and stability of the prion-forming domain. We have found that a diversity of structural features provides a level of redundancy that allows robust folding and stability even in the face of significant sequence alterations and suboptimal environmental conditions. Our findings provide fundamental insights into the structural interactions necessary for self-propagation. Propagation of prion structure seems to require an obligatory level of complexity that may not be reproducible in short peptide models. PMID:24706820

  8. [Errors in literature references in the Nederlands Tijdschrift voor Geneeskunde].

    PubMed

    Hobma, S O; Overbeke, A J

    1992-03-28

    Literature references contain a considerable number of inaccuracies, both in citations and in quotations. We investigated the accuracy of quotations and references in Nederlands Tijdschrift voor Geneeskunde. We checked at random 100 references of articles presented for publication during a period of 4 weeks using Index Medicus. The citation and quotation of another 100 references (50 with a reading list of less than 13, and 50 with a reading list of more than 24 articles) of published original articles were checked, using the original article. In the references of articles presented for publication 70% contained one or more inaccuracies. In the published articles 31% was not completely correct. In 5% these errors prevented immediate identification of the cited article. In one of every three articles a citation error was made: 5 trivial errors, 16 slightly misleading and 12 seriously misleading errors were found. We could not find a relation between the number of citation errors and the length of the reading list. The original source was not cited in 8 articles. Our conclusion is that the number of inaccuracies, in references as well as in citations, is high; authors should check this part of their articles more carefully. Notably the use of multiple references after a sentence with a number of statements is to be avoided.

  9. A Yeast Toxic Mutant of HET-s(218-289) Prion Displays Alternative Intermediates of Amyloidogenesis

    PubMed Central

    Berthelot, Karine; Lecomte, Sophie; Géan, Julie; Immel, Françoise; Cullin, Christophe

    2010-01-01

    Amyloids are thought to be involved in various types of neurodegenerative disorders. Several kinds of intermediates, differing in morphology, size, and toxicity, have been identified in the multistep amyloidogenesis process. However, the mechanisms explaining amyloid toxicity remain unclear. We previously generated a toxic mutant of the nontoxic HET-s(218-289) amyloid in yeast. Here we report that toxic and nontoxic amyloids differ not only in their structures but also in their assembling process. We used multiple and complementary methods to investigate the intermediates formed by these two amyloids. With the methods used, no intermediates were observed for the nontoxic amyloid; however, under the same experimental conditions, the toxic mutant displayed visible oligomeric and fibrillar intermediates. PMID:20713008

  10. Cordless Instruments

    NASA Astrophysics Data System (ADS)

    1981-01-01

    Black & Decker's new cordless lightweight battery powered precision instruments, adapted from NASA's Apollo Lunar Landing program, have been designed to give surgeons optimum freedom and versatility in the operating room. Orthopedic instrument line includes a drill, a driver/reamer and a sagittal saw. All provide up to 20 minutes on a single charge. Power pack is the instrument's handle which is removable for recharging. Microprocessor controlled recharging unit can recharge two power packs together in 30 minutes. Instruments can be gas sterilized, steam-sterilized in an autoclave or immersed for easy cleaning.

  11. Dangerous Substance Advisor: Een Expert Systeem voor het Classificeren van Gevaarlijke Stoffen (Dangerous Substance Advisor: An Expert System for the Classification of Dangerous Substances)

    DTIC Science & Technology

    1990-06-01

    edition, New York, 1986. 5 Accord europ6en relatif au transport international des marchandises Dangereuses par i!oute (ADR) 1985. 6 UN ST/SG/AC.l10/1 3/Add...AFKORTINGEN ADR Accord europ6en relatif au transport international des marchandises Dangereuses par Route. ADNR Accord europ(en relatif au transport ...des marchandises Dangereuses par voie de navigation interieure Rhin. DOT Department Of Transport (USA). DSA Dangerous Substance Advisor. EEC European

  12. Inventory of Simulation and Modeling for the Analysis of Ground Manoeuvre Performance (inventarisatie van vragen en modellen voor de analyse van het grondgebonden optreden)

    DTIC Science & Technology

    2006-04-01

    Radar Intercept On Target PMESII Political, Military, Economic, Social , InfraStructure and Information POKALA Probability of Kill and Lethal Area PRODAS...Commandanten Op welke wijze vormen, O&T professional, leider, bestuurder en inrichten etcetera? diplomaat te zijn.... Moet kunnen communiceren met media 59 De...Directie Directeur Kennis, prof. dr. P. Werkhoven I ex. TNO Defensie en Veiligheid, Directie Directeur Markt , G.D. Klein Baltink 1 ex. TNO Defensie en

  13. SURVEY INSTRUMENT

    DOEpatents

    Borkowski, C J

    1954-01-19

    This pulse-type survey instrument is suitable for readily detecting {alpha} particles in the presence of high {beta} and {gamma} backgrounds. The instruments may also be used to survey for neutrons, {beta} particles and {gamma} rays by employing suitably designed interchangeable probes and selecting an operating potential to correspond to the particular probe.

  14. Instrumentation '79.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1979

    1979-01-01

    Surveys the state of commerical development of analytical instrumentation as reflected by the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy. Includes optical spectroscopy, liquid chromatography, magnetic spectrometers, and x-ray. (Author/MA)

  15. 40 CFR 721.4100 - Tris(disubstituted alkyl) het-er-o-cy-cle.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Tris(disubstituted alkyl) het-er-o-cy-cle. 721.4100 Section 721.4100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Specific Chemical Substances § 721.4100 Tris(disubstituted alkyl) het-er-o-cy-cle. (a) Chemical...

  16. 40 CFR 721.4100 - Tris(disubstituted alkyl) het-er-o-cy-cle.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Tris(disubstituted alkyl) het-er-o-cy-cle. 721.4100 Section 721.4100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Specific Chemical Substances § 721.4100 Tris(disubstituted alkyl) het-er-o-cy-cle. (a) Chemical...

  17. LRS2: A New Integral Field Spectrograph for the HET

    NASA Astrophysics Data System (ADS)

    Tuttle, Sarah E.; Hill, Gary J.; Chonis, Taylor S.; Tonnesen, Stephanie

    2016-01-01

    Here we present LRS2 (Low Resolution Spectrograph) and highlight early science opportunities with the newly upgraded Hobby Eberly telescope (HET). LRS2 is a four-channel optical wavelength (370nm - 1micron) spectrograph based on two VIRUS unit spectrographs. This fiber-fed integral field spectrograph covers a 12" x 6" field of view, switched between the two units (one blue, and one red) at R~2000. We highlight design elements, including the fundamental modification to grisms (from VPH gratings in VIRUS) to access the higher resolution. We discuss early science opportunities, including investigating nearby "blue-bulge" spiral galaxies and their anomalous star formation distribution.

  18. Fiber Diffraction of the Prion-Forming Domain HET-s(218-289) Shows Dehydration-Induced Deformation of a Complex Amyloid Structure

    SciTech Connect

    Wan, William; Stubbs, Gerald

    2014-05-01

    Amyloids are filamentous protein aggregates that can be formed by many different proteins and are associated with both disease and biological functions. The pathogenicities or biological functions of amyloids are determined by their particular molecular structures, making accurate structural models a requirement for understanding their biological effects. One potential factor that can affect amyloid structures is hydration. Previous studies of simple stacked β-sheet amyloids have suggested that dehydration does not impact structure, but other studies indicated dehydration-related structural changes of a putative water-filled nanotube. Our results show that dehydration significantly affects the molecular structure of the fungal prion-forming domain HET-s(218–289), which forms a β-solenoid with no internal solvent-accessible regions. The dehydration-related structural deformation of HET-s(218–289) indicates that water can play a significant role in complex amyloid structures, even when no obvious water-accessible cavities are present.

  19. Fiber Diffraction of the Prion-Forming Domain HET-s(218–289) Shows Dehydration-Induced Deformation of a Complex Amyloid Structure

    PubMed Central

    2015-01-01

    Amyloids are filamentous protein aggregates that can be formed by many different proteins and are associated with both disease and biological functions. The pathogenicities or biological functions of amyloids are determined by their particular molecular structures, making accurate structural models a requirement for understanding their biological effects. One potential factor that can affect amyloid structures is hydration. Previous studies of simple stacked β-sheet amyloids have suggested that dehydration does not impact structure, but other studies indicated dehydration-related structural changes of a putative water-filled nanotube. Our results show that dehydration significantly affects the molecular structure of the fungal prion-forming domain HET-s(218–289), which forms a β-solenoid with no internal solvent-accessible regions. The dehydration-related structural deformation of HET-s(218–289) indicates that water can play a significant role in complex amyloid structures, even when no obvious water-accessible cavities are present. PMID:24670041

  20. [The clinical lesson in the Nederlands Tijdschrift voor Geneeskunde in the last 40 years].

    PubMed

    Maas, K L; Lockefeer, J H

    1997-01-04

    'Lessons of the Week' have been published in Nederlands Tijdschrift voor Geneeskunde since 1928. They consist of a clinical patient demonstration on paper but with the structure and the wording appropriate for a college theater. These lessons are read by three quarters of the journal's readership. They are usually written by senior clinicians.

  1. [Podcasts at The Nederlands Tijdschrift voor Geneeskunde, a first new product].

    PubMed

    2008-06-21

    Podcasts become increasingly available for many biomedical journals. Since the beginning of this year the Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine) has been uploading podcasts on a weekly basis. With this the journal offer its readers audio summaries and interviews with authors for free (www.ntvg.nl).

  2. Mass analysis by scanning transmission electron microscopy and electron diffraction validate predictions of stacked beta-solenoid model of HET-s prion fibrils.

    PubMed

    Sen, Anindito; Baxa, Ulrich; Simon, Martha N; Wall, Joseph S; Sabate, Raimon; Saupe, Sven J; Steven, Alasdair C

    2007-02-23

    Fungal prions are infectious filamentous polymers of proteins that are soluble in uninfected cells. In its prion form, the HET-s protein of Podospora anserina participates in a fungal self/non-self recognition phenomenon called heterokaryon incompatibility. Like other prion proteins, HET-s has a so-called "prion domain" (its C-terminal region, HET-s-(218-289)) that is responsible for induction and propagation of the prion in vivo and for fibril formation in vitro. Prion fibrils are thought to have amyloid backbones of polymerized prion domains. A relatively detailed model has been proposed for prion domain fibrils of HET-s based on a variety of experimental constraints (Ritter, C., Maddelein, M. L., Siemer, A. B., Luhrs, T., Ernst, M., Meier, B. H., Saupe, S. J., and Riek, R. (2005) Nature 435, 844-848). To test specific predictions of this model, which envisages axial stacking of beta-solenoids with two coils per subunit, we examined fibrils by electron microscopy. Electron diffraction gave a prominent meridional reflection at (0.47 nm)(-1), indicative of cross-beta structure, as predicted. STEM (scanning transmission electron microscopy) mass-per-unit-length measurements yielded 1.02 +/- 0.16 subunits per 0.94 nm, in agreement with the model prediction (1 subunit per 0.94 nm). This is half the packing density of approximately 1 subunit per 0.47 nm previously obtained for fibrils of the yeast prion proteins, Ure2p and Sup35p, whence it follows that the respective amyloid architectures are basically different.

  3. Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria.

    SciTech Connect

    Kim, Y.; Joachimiak, G.; Ye, Z.; Binkowski, T; Zhang, R.; Gornicki, P.; Callahan, S.; Hess, W.; Haselkorn, R.; Joachimiak, A.

    2011-06-21

    HetR is an essential regulator of heterocyst development in cyanobacteria. HetR binds to a DNA palindrome upstream of the hetP gene. We report the crystal structure of HetR from Fischerella at 3.0 {angstrom}. The protein is a dimer comprised of a central DNA-binding unit containing the N-terminal regions of the two subunits organized with two helix-turn-helix motifs; two globular flaps extending in opposite directions; and a hood over the central core formed from the C-terminal subdomains. The flaps and hood have no structural precedent in the protein database, therefore representing new folds. The structural assignments are supported by site-directed mutagenesis and DNA-binding studies. We suggest that HetR serves as a scaffold for assembly of transcription components critical for heterocyst development.

  4. Wild type and mutants of the HET-s(218-289) prion show different flexibility at fibrillar ends: a simulation study.

    PubMed

    Friedman, Ran; Caflisch, Amedeo

    2014-03-01

    The C-terminal segment (residues 218-289) of the HET-s protein of the filamentous fungus Podosporina anserina is a prion-forming domain. The structural model of the HET-s(218-289) amyloid fibril based on solid-state nuclear magnetic resonance (NMR) restraints shows a β solenoid topology which is comprised of a β-sheet core and interconnecting loops. For the single-point mutants Phe286Ala and Trp287Ala, slower aggregation rates in vitro and loss of prionic infectivity have been reported recently. Here we have used molecular dynamics to compare the flexibility of the mutants and wild type. The simulations, initiated from a trimeric aggregate extracted from the NMR structural model, show structural stability on a 100-ns time scale for wild type and mutants. Analysis of the fluctuations along the simulations reveals that the mutants are less flexible than the wild type in the C-terminal segment at only one of the two external monomers. Analysis of interaction energy and buried accessible surface indicates that residue Phe286 in particular is stabilized in the Trp287Ala mutant. The simulation results provide an atomistic explanation of the suggestion (based on indirect experimental evidence) that flexibility at the protofibril end(s) is required for fibril elongation. Moreover, they provide further evidence that the growth of the HET-s amyloid fibril is directional.

  5. Heterogeneous Seeding of a Prion Structure by a Generic Amyloid Form of the Fungal Prion-forming Domain HET-s(218-289)

    SciTech Connect

    Wan, William; Bian, Wen; McDonald, Michele; Kijac, Aleksandra; Wemmer, David E.; Stubbs, Gerald

    2013-11-13

    The fungal prion-forming domain HET-s(218–289) forms infectious amyloid fibrils at physiological pH that were shown by solid-state NMR to be assemblies of a two-rung β-solenoid structure. Under acidic conditions, HET-s(218–289) has been shown to form amyloid fibrils that have very low infectivity in vivo, but structural information about these fibrils has been very limited. We show by x-ray fiber diffraction that the HET-s(218–289) fibrils formed under acidic conditions have a stacked β-sheet architecture commonly found in short amyloidogenic peptides and denatured protein aggregates. At physiological pH, stacked β-sheet fibrils nucleate the formation of the infectious β-solenoid prions in a process of heterogeneous seeding, but do so with kinetic profiles distinct from those of spontaneous or homogeneous (seeded with infectious β-solenoid fibrils) fibrillization. Several serial passages of stacked β-sheet-seeded solutions lead to fibrillization kinetics similar to homogeneously seeded solutions. Our results directly show that structural mutation can occur between substantially different amyloid architectures, lending credence to the suggestion that the processes of strain adaptation and crossing species barriers are facilitated by structural mutation.

  6. Heterogeneous Seeding of a Prion Structure by a Generic Amyloid Form of the Fungal Prion-forming Domain HET-s(218–289)*

    PubMed Central

    Wan, William; Bian, Wen; McDonald, Michele; Kijac, Aleksandra; Wemmer, David E.; Stubbs, Gerald

    2013-01-01

    The fungal prion-forming domain HET-s(218–289) forms infectious amyloid fibrils at physiological pH that were shown by solid-state NMR to be assemblies of a two-rung β-solenoid structure. Under acidic conditions, HET-s(218–289) has been shown to form amyloid fibrils that have very low infectivity in vivo, but structural information about these fibrils has been very limited. We show by x-ray fiber diffraction that the HET-s(218–289) fibrils formed under acidic conditions have a stacked β-sheet architecture commonly found in short amyloidogenic peptides and denatured protein aggregates. At physiological pH, stacked β-sheet fibrils nucleate the formation of the infectious β-solenoid prions in a process of heterogeneous seeding, but do so with kinetic profiles distinct from those of spontaneous or homogeneous (seeded with infectious β-solenoid fibrils) fibrillization. Several serial passages of stacked β-sheet-seeded solutions lead to fibrillization kinetics similar to homogeneously seeded solutions. Our results directly show that structural mutation can occur between substantially different amyloid architectures, lending credence to the suggestion that the processes of strain adaptation and crossing species barriers are facilitated by structural mutation. PMID:23986444

  7. Research Instruments

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The GENETI-SCANNER, newest product of Perceptive Scientific Instruments, Inc. (PSI), rapidly scans slides, locates, digitizes, measures and classifies specific objects and events in research and diagnostic applications. Founded by former NASA employees, PSI's primary product line is based on NASA image processing technology. The instruments karyotype - a process employed in analysis and classification of chromosomes - using a video camera mounted on a microscope. Images are digitized, enabling chromosome image enhancement. The system enables karyotyping to be done significantly faster, increasing productivity and lowering costs. Product is no longer being manufactured.

  8. Geoscience instrumentation

    NASA Technical Reports Server (NTRS)

    Wolff, E. A. (Editor); Mercanti, E. P.

    1974-01-01

    Geoscience instrumentation systems are considered along with questions of geoscience environment, signal processing, data processing, and design problems. Instrument platforms are examined, taking into account ground platforms, airborne platforms, ocean platforms, and space platforms. In situ and laboratory sensors described include acoustic wave sensors, age sensors, atmospheric constituent sensors, biological sensors, cloud particle sensors, electric field sensors, electromagnetic field sensors, precision geodetic sensors, gravity sensors, ground constituent sensors, horizon sensors, humidity sensors, ion and electron sensors, magnetic field sensors, tide sensors, and wind sensors. Remote sensors are discussed, giving attention to sensing techniques, acoustic echo-sounders, gamma ray sensors, optical sensors, radar sensors, and microwave radiometric sensors.

  9. Instrumented SSH

    SciTech Connect

    Campbell, Scott; Campbell, Scott

    2009-05-27

    NERSC recently undertook a project to access and analyze Secure Shell (SSH) related data. This includes authentication data such as user names and key fingerprints, interactive session data such as keystrokes and responses, and information about noninteractive sessions such as commands executed and files transferred. Historically, this data has been inaccessible with traditional network monitoring techniques, but with a modification to the SSH daemon, this data can be passed directly to intrusion detection systems for analysis. The instrumented version of SSH is now running on all NERSC production systems. This paper describes the project, details about how SSH was instrumented, and the initial results of putting this in production.

  10. Weather Instruments.

    ERIC Educational Resources Information Center

    Brantley, L. Reed, Sr.; Demanche, Edna L.; Klemm, E. Barbara; Kyselka, Will; Phillips, Edwin A.; Pottenger, Francis M.; Yamamoto, Karen N.; Young, Donald B.

    This booklet presents some activities to measure various weather phenomena. Directions for constructing a weather station are included. Instruments including rain gauges, thermometers, wind vanes, wind speed devices, humidity devices, barometers, atmospheric observations, a dustfall jar, sticky-tape can, detection of gases in the air, and pH of…

  11. Vestibular responses to linear acceleration are absent in otoconia-deficient C57BL/6JEi-het mice

    NASA Technical Reports Server (NTRS)

    Jones, S. M.; Erway, L. C.; Bergstrom, R. A.; Schimenti, J. C.; Jones, T. A.

    1999-01-01

    Vestibular evoked potentials (VsEPs) were measured in normal mice and in mice homozygous for the head tilt mutation (het/het, abbr. het). The het mice lack otoconia, the inertial mass critical for natural stimulation of inner ear gravity receptors. Our findings demonstrate that vestibular neural responses to pulsed linear acceleration are absent in het mice. The results: (1) confirm that adequate sensory stimuli fail to activate gravity receptors in the het model; and (2) serve as definitive evidence that far-field vestibular responses to pulsed linear acceleration depend critically on otolith end organs. The C57BL/6JEi-het mouse may be an excellent model of gravity receptor sensory deprivation.

  12. RHIC instrumentation

    NASA Astrophysics Data System (ADS)

    Shea, T. J.; Witkover, R. L.

    1998-12-01

    The Relativistic Heavy Ion Collider (RHIC) consists of two 3.8 km circumference rings utilizing 396 superconducting dipoles and 492 superconducting quadrupoles. Each ring will accelerate approximately 60 bunches of 1011 protons to 250 GeV, or 109 fully stripped gold ions to 100 GeV/nucleon. Commissioning is scheduled for early 1999 with detectors for some of the 6 intersection regions scheduled for initial operation later in the year. The injection line instrumentation includes: 52 beam position monitor (BPM) channels, 56 beam loss monitor (BLM) channels, 5 fast integrating current transformers and 12 video beam profile monitors. The collider ring instrumentation includes: 667 BPM channels, 400 BLM channels, wall current monitors, DC current transformers, ionization profile monitors (IPMs), transverse feedback systems, and resonant Schottky monitors. The use of superconducting magnets affected the beam instrumentation design. The BPM electrodes must function in a cryogenic environment and the BLM system must prevent magnet quenches from either fast or slow losses with widely different rates. RHIC is the first superconducting accelerator to cross transition, requiring close monitoring of beam parameters at this time. High space-charge due to the fully stripped gold ions required the IPM to collect magnetically guided electrons rather than the conventional ions. Since polarized beams will also be accelerated in RHIC, additional constraints were put on the instrumentation. The orbit must be well controlled to minimize depolarizing resonance strengths. Also, the position monitors must accommodate large orbit displacements within the Siberian snakes and spin rotators. The design of the instrumentation will be presented along with results obtained during bench tests, the injection line commissioning, and the first sextant test.

  13. RHIC instrumentation

    SciTech Connect

    Shea, T. J.; Witkover, R. L.

    1998-12-10

    The Relativistic Heavy Ion Collider (RHIC) consists of two 3.8 km circumference rings utilizing 396 superconducting dipoles and 492 superconducting quadrupoles. Each ring will accelerate approximately 60 bunches of 10{sup 11} protons to 250 GeV, or 10{sup 9} fully stripped gold ions to 100 GeV/nucleon. Commissioning is scheduled for early 1999 with detectors for some of the 6 intersection regions scheduled for initial operation later in the year. The injection line instrumentation includes: 52 beam position monitor (BPM) channels, 56 beam loss monitor (BLM) channels, 5 fast integrating current transformers and 12 video beam profile monitors. The collider ring instrumentation includes: 667 BPM channels, 400 BLM channels, wall current monitors, DC current transformers, ionization profile monitors (IPMs), transverse feedback systems, and resonant Schottky monitors. The use of superconducting magnets affected the beam instrumentation design. The BPM electrodes must function in a cryogenic environment and the BLM system must prevent magnet quenches from either fast or slow losses with widely different rates. RHIC is the first superconducting accelerator to cross transition, requiring close monitoring of beam parameters at this time. High space-charge due to the fully stripped gold ions required the IPM to collect magnetically guided electrons rather than the conventional ions. Since polarized beams will also be accelerated in RHIC, additional constraints were put on the instrumentation. The orbit must be well controlled to minimize depolarizing resonance strengths. Also, the position monitors must accommodate large orbit displacements within the Siberian snakes and spin rotators. The design of the instrumentation will be presented along with results obtained during bench tests, the injection line commissioning, and the first sextant test.

  14. RHIC instrumentation

    SciTech Connect

    Shea, T.J.; Witkover, R.L.

    1998-12-01

    The Relativistic Heavy Ion Collider (RHIC) consists of two 3.8 km circumference rings utilizing 396 superconducting dipoles and 492 superconducting quadrupoles. Each ring will accelerate approximately 60 bunches of 10{sup 11} protons to 250 GeV, or 10{sup 9} fully stripped gold ions to 100 GeV/nucleon. Commissioning is scheduled for early 1999 with detectors for some of the 6 intersection regions scheduled for initial operation later in the year. The injection line instrumentation includes: 52 beam position monitor (BPM) channels, 56 beam loss monitor (BLM) channels, 5 fast integrating current transformers and 12 video beam profile monitors. The collider ring instrumentation includes: 667 BPM channels, 400 BLM channels, wall current monitors, DC current transformers, ionization profile monitors (IPMs), transverse feedback systems, and resonant Schottky monitors. The use of superconducting magnets affected the beam instrumentation design. The BPM electrodes must function in a cryogenic environment and the BLM system must prevent magnet quenches from either fast or slow losses with widely different rates. RHIC is the first superconducting accelerator to cross transition, requiring close monitoring of beam parameters at this time. High space-charge due to the fully stripped gold ions required the IPM to collect magnetically guided electrons rather than the conventional ions. Since polarized beams will also be accelerated in RHIC, additional constraints were put on the instrumentation. The orbit must be well controlled to minimize depolarizing resonance strengths. Also, the position monitors must accommodate large orbit displacements within the Siberian snakes and spin rotators. The design of the instrumentation will be presented along with results obtained during bench tests, the injection line commissioning, and the first sextant test. {copyright} {ital 1998 American Institute of Physics.}

  15. Bewegingshinder van Impactbeschermingsmiddelen voor de ME van de KMar (Restriction of Movement of Impact Protective Clothing for the Anti-Riot Squad of the Dutch Military Police)

    DTIC Science & Technology

    2007-12-01

    impactbeschermingsmiddelen voor de ME van de KMar Resultaten van ergonomi etesten die uitgevoerd zijn met irnpactbeschermingsmiddelen...testen van fysieke ergonomie bestaat voor deze kledingpakketten, heeft bet KPU-bedrijf TNO gevraagd hiernaar onderzoek te doen. TNO heeft al vaker voor...testen: ’V-Top’ en ’KLPD nieuwe kleding’. TNO heeft verschillende testen uitgevoerd om de kledingpakketten te beoordelen op fysieke ergonomie . TNO

  16. [Original articles in the Nederlands Tijdschrift voor Geneeskunde in the last 40 years].

    PubMed

    Maas, K L; Overbeke, A J

    1997-01-04

    Original articles offer the reader of the Nederlands Tijdschrift voor Geneeskunde information about Dutch scientific research. These readers are selective but appreciative. The emphasis has shifted in the last 40 years from case histories, introduction of new techniques, literature studies and opinions, to qualitatively and methodologically adequate numerical studies, with strictly arranged presentation. The numbers of patients per study have increased substantially, and statistical processing has grown more extensive. Cost-benefit analyses appeared. The number of prospective studies remained constant.

  17. A Decision Support System for Manpower Planning (Een Beslissingsondersteunend Systeem voor Personeels-Planning

    DTIC Science & Technology

    1990-10-01

    over bet feitelijke ge- bruik van bet beslissingsondersteunende systeem . TNO report Page 4 ABSTRACT 2 SAMENVATTING 3 CONTENTS 4 SURVEY OF FIGURES 5 1...manpower planning and policy analysis. We describe the decision making context in which the system can be used and give a survey of its contents and its...Availability Codes Avail and/or Dist Speoial 7NO report Page 3 rapport no. FEL-90-B300 titel Een beslissingsondersteunend systeem voor personeels

  18. Escape from Het-6 Incompatibility in Neurospora Crassa Partial Diploids Involves Preferential Deletion within the Ectopic Segment

    PubMed Central

    Smith, M. L.; Yang, C. J.; Metzenberg, R. L.; Glass, N. L.

    1996-01-01

    Self-incompatible het-6(OR)/het-6(PA) partial diploids of Neurospora crassa were selected from a cross involving the translocation strain, T(IIL -> IIIR)AR18, and a normal sequence strain. About 25% of the partial diploids exhibited a marked increase in growth rate after 2 weeks, indicating that ``escape'' from het-6 incompatibility had occurred. Near isogenic tester strains with different alleles (het-6(OR) and het-6(PA)) were constructed and used to determine that 80 of 96 escape strains tested were het-6(PA), retaining the het-6 allele found in the normal-sequence LGII position; 16 were het-6(OR), retaining the allele in the translocated position. Restriction fragment length polymorphisms in 45 escape strains were examined with probes made from cosmids that spanned the translocated region. Along with electrophoretic analysis of chromosomes from three escape strains, RFLPs showed that escape is associated with deletion of part of one or the other of the duplicated DNA segments. Deletions ranged in size from ~70 kbp up to putatively the entire 270-kbp translocated region but always included a 35-kbp region wherein we hypothesize het-6 is located. The deletion spectrum at het-6 thus resembles other cases where mitotic deletions occur such as of tumor suppressor genes and of the hprt gene (coding for hypoxanthine-guanine phosphoribosyl-transferase) in humans. PMID:8889517

  19. Structural insights into HetR−PatS interaction involved in cyanobacterial pattern formation

    PubMed Central

    Hu, Hai-Xi; Jiang, Yong-Liang; Zhao, Meng-Xi; Cai, Kun; Liu, Sanling; Wen, Bin; Lv, Pei; Zhang, Yonghui; Peng, Junhui; Zhong, Hui; Yu, Hong-Mei; Ren, Yan-Min; Zhang, Zhiyong; Tian, Changlin; Wu, Qingfa; Oliveberg, Mikael; Zhang, Cheng-Cai; Chen, Yuxing; Zhou, Cong-Zhao

    2015-01-01

    The one-dimensional pattern of heterocyst in the model cyanobacterium Anabaena sp. PCC 7120 is coordinated by the transcription factor HetR and PatS peptide. Here we report the complex structures of HetR binding to DNA, and its hood domain (HetRHood) binding to a PatS-derived hexapeptide (PatS6) at 2.80 and 2.10 Å, respectively. The intertwined HetR dimer possesses a couple of novel HTH motifs, each of which consists of two canonical α-helices in the DNA-binding domain and an auxiliary α-helix from the flap domain of the neighboring subunit. Two PatS6 peptides bind to the lateral clefts of HetRHood, and trigger significant conformational changes of the flap domain, resulting in dissociation of the auxiliary α-helix and eventually release of HetR from the DNA major grove. These findings provide the structural insights into a prokaryotic example of Turing model. PMID:26576507

  20. Herontwerp Ballistisch vest voor Vrouwen: Fase 1 (Redesign Ballistic Vest for Women: Phase 1)

    DTIC Science & Technology

    2008-09-01

    TNO Rapport 20081027309 Nederlandse Organisatie soor toegepast-natuurwetenschiappeljk TNO efe sie n V ilig idonlderzoek/ Netherlands Organisation...houden van bet plaatoppervlak, het lichaam onbeschermd blij ft. Nederland is niet bet enige land dat overweegt om de vorm van de ballistische platen aan te

  1. Optical Instruments

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Precision Lapping and Optical Co. has developed a wide variety of hollow retroreflector systems for applications involving the entire optical spectrum; they are, according to company literature, cheaper, more accurate, lighter and capable of greater size than solid prisms. Precision Lapping's major customers are aerospace and defense companies, government organizations, R&D and commercial instrument companies. For example, Precision Lapping supplies hollow retroreflectors for the laser fire control system of the Army's Abrams tank, and retroreflectors have been and are being used in a number of space tests relative to the Air Force's Strategic Defense Initiative research program. An example of a customer/user is Chesapeake Laser Systems, producer of the Laser Tracker System CMS-2000, which has applications in SDI research and industrial robotics. Another customer is MDA Scientific, Inc., manufacturer of a line of toxic gas detection systems used to monitor hazardous gases present in oil fields, refineries, offshore platforms, chemical plants, waste storage sites and other locations where gases are released into the environment.

  2. Relationships between the ABC-exporter HetC and peptides that regulate the spatiotemporal pattern of heterocyst distribution in Anabaena.

    PubMed

    Corrales-Guerrero, Laura; Flores, Enrique; Herrero, Antonia

    2014-01-01

    In the model cyanobacterium Anabaena sp. PCC 7120, cells called heterocysts that are specialized in the fixation of atmospheric nitrogen differentiate from vegetative cells of the filament in the absence of combined nitrogen. Heterocysts follow a specific distribution pattern along the filament, and a number of regulators have been identified that influence the heterocyst pattern. PatS and HetN, expressed in the differentiating cells, inhibit the differentiation of neighboring cells. At least PatS appears to be processed and transferred from cell to cell. HetC is similar to ABC exporters and is required for differentiation. We present an epistasis analysis of these regulatory genes and of genes, hetP and asr2819, successively downstream from hetC, and we have studied the localization of HetC and HetP by use of GFP fusions. Inactivation of patS, but not of hetN, allowed differentiation to proceed in a hetC background, whereas inactivation of hetC in patS or patS hetN backgrounds decreased the frequency of contiguous proheterocysts. A HetC-GFP protein is localized to the heterocysts and especially near their cell poles, and a putative HetC peptidase domain was required for heterocyst differentiation but not for HetC-GFP localization. hetP is also required for heterocyst differentiation. A HetP-GFP protein localized mostly near the heterocyst poles. ORF asr2819, which we denote patC, encodes an 84-residue peptide and is induced upon nitrogen step-down. Inactivation of patC led to a late spreading of the heterocyst pattern. Whereas HetC and HetP appear to have linked functions that allow heterocyst differentiation to progress, PatC may have a role in selecting sites of differentiation, suggesting that these closely positioned genes may be functionally related.

  3. Spatial fluctuations in expression of the heterocyst differentiation regulatory gene hetR in Anabaena filaments.

    PubMed

    Corrales-Guerrero, Laura; Tal, Asaf; Arbel-Goren, Rinat; Mariscal, Vicente; Flores, Enrique; Herrero, Antonia; Stavans, Joel

    2015-04-01

    Under nitrogen deprivation, filaments of the cyanobacterium Anabaena undergo a process of development, resulting in a one-dimensional pattern of nitrogen-fixing heterocysts separated by about ten photosynthetic vegetative cells. Many aspects of gene expression before nitrogen deprivation and during the developmental process remain to be elucidated. Furthermore, the coupling of gene expression fluctuations between cells along a multicellular filament is unknown. We studied the statistics of fluctuations of gene expression of HetR, a transcription factor essential for heterocyst differentiation, both under steady-state growth in nitrogen-rich conditions and at different times following nitrogen deprivation, using a chromosomally-encoded translational hetR-gfp fusion. Statistical analysis of fluorescence at the individual cell level in wild-type and mutant filaments demonstrates that expression fluctuations of hetR in nearby cells are coupled, with a characteristic spatial range of circa two to three cells, setting the scale for cellular interactions along a filament. Correlations between cells predominantly arise from intercellular molecular transfer and less from cell division. Fluctuations after nitrogen step-down can build up on those under nitrogen-replete conditions. We found that under nitrogen-rich conditions, basal, steady-state expression of the HetR inhibitor PatS, cell-cell communication influenced by the septal protein SepJ and positive HetR auto-regulation are essential determinants of fluctuations in hetR expression and its distribution along filaments. A comparison between the expression of hetR-gfp under nitrogen-rich and nitrogen-poor conditions highlights the differences between the two HetR inhibitors PatS and HetN, as well as the differences in specificity between the septal proteins SepJ and FraC/FraD. Activation, inhibition and cell-cell communication lie at the heart of developmental processes. Our results show that proteins involved in these

  4. [Editing of articles accepted for publication by the Nederlands Tijdschrift voor Geneeskunde].

    PubMed

    Walvoort, H C

    1997-01-04

    The Nederlands Tijdschrift voor Geneeskunde has been publishing medical science in Dutch for 140 years. To bridge the gap between the specialist science and the general medical reader several sections in the accepted papers have to be clarified, simplified and shortened by post acceptance editing. The style and language of the authors is treated with respect. Changes are made if the article does not comply with internationally accepted rules on scientific reporting, if the article can not be understood using currently authoritative general and medical books of reference, and if its language does not comply with generally accepted Dutch rules for grammar and spelling.

  5. Velocity Measurements on the Electric Gun Developed at the TNO Prins Maurits Laboratory (Snelheidheidsmetingen aan de bij het Prins Maurits Laboratorium Ontwikkelde Electric Gun)

    DTIC Science & Technology

    1993-03-01

    8217te veel’ aluminium explodeert. Dit wordt weergegeven door het gearceer.1e gebied. Doordat er een stuk aluminiumn over het koper uitsteekt explodeert...worden de beperkingen van de verschillende meetmethoden toegelicht. De grootste fout komt uit de snelheidsmeting. Het aantal fibers (6 stuks ), de

  6. Methoden voor Voorraadbeheersing van Repareerbare Reservedelen: METRIC en Enkele Varianten (Methodes for Repairable Item Inventory Control: METRIC and Some Variants)

    DTIC Science & Technology

    1990-08-01

    geval van repareerbare items (voor niet-repareerbare items altijd 0), backorders - aantal exemplaren/ stuks van een item dat niet direct geleverd kan...worden (bet aantal stuks in nalevering). Hierbij geldt automatisch dat van de termen "on hand" en "backorders" minstens een van beide gelijk san nul is

  7. Low activated incore instrument

    DOEpatents

    Ekeroth, D.E.

    1994-04-19

    Instrumentation is described for nuclear reactor head-mounted incore instrumentation systems fabricated of low nuclear cross section materials (i.e., zirconium or titanium). The instrumentation emits less radiation than that fabricated of conventional materials. 9 figures.

  8. Low activated incore instrument

    DOEpatents

    Ekeroth, Douglas E.

    1994-01-01

    Instrumentation for nuclear reactor head-mounted incore instrumentation systems fabricated of low nuclear cross section materials (i.e., zirconium or titanium). The instrumentation emits less radiation than that fabricated of conventional materials.

  9. Evaluating musical instruments

    SciTech Connect

    Campbell, D. Murray

    2014-04-01

    Scientific measurements of sound generation and radiation by musical instruments are surprisingly hard to correlate with the subtle and complex judgments of instrumental quality made by expert musicians.

  10. The heterocyst differentiation transcriptional regulator HetR of the filamentous cyanobacterium Anabaena forms tetramers and can be regulated by phosphorylation.

    PubMed

    Valladares, Ana; Flores, Enrique; Herrero, Antonia

    2016-02-01

    Many filamentous cyanobacteria respond to the external cue of nitrogen scarcity by the differentiation of heterocysts, cells specialized in the fixation of atmospheric nitrogen in oxic environments. Heterocysts follow a spatial pattern along the filament of two heterocysts separated by ca. 10-15 vegetative cells performing oxygenic photosynthesis. HetR is a transcriptional regulator that directs heterocyst differentiation. In the model strain Anabaena sp. PCC 7120, the HetR protein was observed in various oligomeric forms in vivo, including a tetramer that peaked with maximal hetR expression during differentiation. Tetramers were not detected in a hetR point mutant incapable of differentiation, but were conspicuous in an over-differentiating strain lacking the PatS inhibitor. In differentiated filaments the HetR tetramer was restricted to heterocysts, being undetectable in vegetative cells. HetR co-purified with RNA polymerase from Anabaena mainly as a tetramer. In vitro, purified recombinant HetR was distributed between monomers, dimers, trimers and tetramers, and it was phosphorylated when incubated with (γ-(32)P)ATP. Phosphorylation and PatS hampered the accumulation of HetR tetramers and impaired HetR binding to DNA. In summary, tetrameric HetR appears to represent a functionally relevant form of HetR, whose abundance in the Anabaena filament could be negatively regulated by phosphorylation and by PatS.

  11. Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models.

    PubMed

    Jain, Meenu; Gamage, Nipuni-Dhanesha H; Alsulami, Meshal; Shankar, Adarsh; Achyut, Bhagelu R; Angara, Kartik; Rashid, Mohammad H; Iskander, Asm; Borin, Thaiz F; Wenbo, Zhi; Ara, Roxan; Ali, Meser M; Lebedyeva, Iryna; Chwang, Wilson B; Guo, Austin; Bagher-Ebadian, Hassan; Arbab, Ali S

    2017-01-31

    Glioblastoma (GBM) is a hypervascular primary brain tumor with poor prognosis. HET0016 is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth. Therefore, to explore novel treatments, we have generated an improved intravenous (IV) formulation of HET0016 with HPßCD and tested in animal models of human and syngeneic GBM. Administration of a single IV dose resulted in 7-fold higher levels of HET0016 in plasma and 3.6-fold higher levels in tumor at 60 min than that in IP route. IV treatment with HPßCD-HET0016 decreased tumor growth, and altered vascular kinetics in early and late treatment groups (p < 0.05). Similar growth inhibition was observed in syngeneic GL261 GBM (p < 0.05). Survival studies using patient derived xenografts of GBM811, showed prolonged survival to 26 weeks in animals treated with focal radiation, in combination with HET0016 and TMZ (p < 0.05). We observed reduced expression of markers of cell proliferation (Ki-67), decreased neovascularization (laminin and αSMA), in addition to inflammation and angiogenesis markers in the treatment group (p < 0.05). Our results indicate that HPßCD-HET0016 is effective in inhibiting tumor growth through decreasing proliferation, and neovascularization. Furthermore, HPßCD-HET0016 significantly prolonged survival in PDX GBM811 model.

  12. Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models

    PubMed Central

    Jain, Meenu; Gamage, Nipuni-Dhanesha H.; Alsulami, Meshal; Shankar, Adarsh; Achyut, Bhagelu R.; Angara, Kartik; Rashid, Mohammad H.; Iskander, Asm; Borin, Thaiz F.; Wenbo, Zhi; Ara, Roxan; Ali, Meser M.; Lebedyeva, Iryna; Chwang, Wilson B.; Guo, Austin; Bagher-Ebadian, Hassan; Arbab, Ali S.

    2017-01-01

    Glioblastoma (GBM) is a hypervascular primary brain tumor with poor prognosis. HET0016 is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth. Therefore, to explore novel treatments, we have generated an improved intravenous (IV) formulation of HET0016 with HPßCD and tested in animal models of human and syngeneic GBM. Administration of a single IV dose resulted in 7-fold higher levels of HET0016 in plasma and 3.6-fold higher levels in tumor at 60 min than that in IP route. IV treatment with HPßCD-HET0016 decreased tumor growth, and altered vascular kinetics in early and late treatment groups (p < 0.05). Similar growth inhibition was observed in syngeneic GL261 GBM (p < 0.05). Survival studies using patient derived xenografts of GBM811, showed prolonged survival to 26 weeks in animals treated with focal radiation, in combination with HET0016 and TMZ (p < 0.05). We observed reduced expression of markers of cell proliferation (Ki-67), decreased neovascularization (laminin and αSMA), in addition to inflammation and angiogenesis markers in the treatment group (p < 0.05). Our results indicate that HPßCD-HET0016 is effective in inhibiting tumor growth through decreasing proliferation, and neovascularization. Furthermore, HPßCD-HET0016 significantly prolonged survival in PDX GBM811 model. PMID:28139732

  13. VIRUS: a massively replicated IFU spectrograph for HET

    NASA Astrophysics Data System (ADS)

    Hill, Gary J.; MacQueen, Phillip J.; Tejada, Carlos; Cobos, Francisco J.; Palunas, Povilas; Gebhardt, Karl; Drory, Niv

    2004-09-01

    We investigate the role of industrial replication in the construction of the next generation of spectrographs for large telescopes. In this paradigm, a simple base spectrograph unit is replicated to provide multiplex advantage, while the engineering costs are amortized over many copies. We argue that this is a cost-effective approach when compared to traditional spectrograph design, where each instrument is essentially a one-off prototype with heavy expenditure on engineering effort. As an example of massive replication, we present the design of, and the science drivers for, the Visible IFU Replicable Ultra-cheap Spectrograph (VIRUS). This instrument is made up of 132 individually small and simple spectrographs, each fed by a fiber integral field unit. The total VIRUS-132 instrument covers ~29 sq. arcminutes per observation, providing integral field spectroscopy from 340 to 570 nm, simultaneously, of 32,604 spatial elements, each 1 sq. arcsecond on the sky. VIRUS-132 will be mounted on the 9.2 m Hobby-Eberly Telescope and fed by a new wide-field corrector with a science field in excess of 16.5 arcminutes diameter. VIRUS represents a new approach to spectrograph design, offering the science multiplex advantage of huge sky coverage for an integral field spectrograph, coupled with the engineering multiplex advantage of >102 spectrographs making up a whole.

  14. [140 years Nederlands Tijdschrift voor Geneeskunde. 140 volumes: looking back, looking in and looking forward].

    PubMed

    van Gijn, J

    1997-01-04

    The Nederlands Tijdschrift voor Geneeskunde was founded in 1856 when five of the nine medical journal in the Netherlands decided to join hands and launch a new medical weekly (in Dutch). About 800 manuscripts are now submitted each year, most of which are peer reviewed before acceptance. The editorial board consists of about twenty medical specialists who have agreed to carry out the bulk of the peer review for a period of three years each. After retirement from the editorial board, they are a lifelong member of the Association of the Dutch Journal of Medicine. After acceptance, articles are thoroughly scientifically and linguistically edited to ensure that the general medical readership will understand them. About 50% of the accepted papers are published within twenty weeks. In the near future the journal pages will have more illustrations and more coloured ones, educative panels, and a digest of Dutch research published in international journals.

  15. Astronomical Instruments in India

    NASA Astrophysics Data System (ADS)

    Sarma, Sreeramula Rajeswara

    The earliest astronomical instruments used in India were the gnomon and the water clock. In the early seventh century, Brahmagupta described ten types of instruments, which were adopted by all subsequent writers with minor modifications. Contact with Islamic astronomy in the second millennium AD led to a radical change. Sanskrit texts began to lay emphasis on the importance of observational instruments. Exclusive texts on instruments were composed. Islamic instruments like the astrolabe were adopted and some new types of instruments were developed. Production and use of these traditional instruments continued, along with the cultivation of traditional astronomy, up to the end of the nineteenth century.

  16. Mars Miniature Science Instruments

    NASA Technical Reports Server (NTRS)

    Kim, Soon Sam; Hayati, Samad; Lavery, David; McBrid, Karen

    2006-01-01

    For robotic Mars missions, all the science information is gathered through on-board miniature instruments that have been developed through many years of R&D. Compared to laboratory counterparts, the rover instruments require miniaturization, such as low mass (1-2 kg), low power (> 10 W) and compact (1-2 liter), yet with comparable sensitivity. Since early 1990's, NASA recognized the need for the miniature instruments and launched several instrument R&D programs, e.g., PIDDP (Planetary Instrument Definition and Development). However, until 1998, most of the instrument R&D programs supported only up to a breadboard level (TRL 3, 4) and there is a need to carry such instruments to flight qualifiable status (TU 5, 6) to respond to flight AOs (Announcement of Opportunity). Most of flight AOs have only limited time and financial resources, and can not afford such instrument development processes. To bridge the gap between instrument R&D programs and the flight instrument needs, NASA's Mars Technology Program (MTP) created advanced instrumentation program, Mars Instrument Development Project (MIDP). MIDP candidate instruments are selected through NASA Research Announcement (NRA) process [l]. For example, MIDP 161998-2000) selected and developed 10 instruments, MIDP II (2003-2005) 16 instruments, and MIDP III (2004-2006) II instruments.Working with PIs, JPL has been managing the MIDP tasks since September 1998. All the instruments being developed under MIDP have been selected through a highly competitive NRA process, and employ state-of-the-art technology. So far, four MIDP funded instruments have been selected by two Mars missions (these instruments have further been discussed in this paper).

  17. Health empowerment technologies (HET): building a web-based tool to empower older African American patient-doctor relationships.

    PubMed

    Winbush, Greta Berry; McDougle, Leon; Labranche, Lynda; Khan, Sidra; Tolliver, Sophia

    2013-11-01

    Responding to health and digital inequities among older African Americans, a customized web-based mobile health information intervention is being developed for this vulnerable group and their doctors as part of the Health Empowerment Technologies (HET) Project. The belief is an empowered patient-doctor relationship leads to more improved health outcomes than patient empowerment alone. Using health information technology to empower both older African Americans and their doctors by increasing health literacy and computer capacities of both is the major HET study aim. A focus group of older African American patients and one of their doctors yielded data to help build the HET. Thematic analysis of opinions and preferences about the content and structure of the HET revealed concordance and asymmetry among the patients and doctors. While challenges prevail in its construction, building this ethnicity-specific web-based health information technology presents the opportunity to integrate health information technology in clinical encounters for every patient.

  18. Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells.

    PubMed

    Oesterreich, S; Lee, A V; Sullivan, T M; Samuel, S K; Davie, J R; Fuqua, S A

    1997-11-01

    Since the small heat shock protein hsp27 enhances both growth and drug resistance in breast cancer cells, and is a bad prognostic factor in certain subsets of breast cancer patients, we have characterized the transcriptional regulation of hsp27, with the long-term goal of targeting its expression clinically. The majority of the promoter activity resides in the most proximal 200 bp. This region contains an imperfect estrogen response element (ERE) that is separated by a 13-bp spacer that contains a TATA box. Gel-shift analysis revealed the binding of a protein (termed HET for Hsp27-ERE-TATA-binding protein) to this region that was neither the estrogen receptor nor TATA-binding protein. We cloned a complete cDNA (2.9 kb) for HET from an MCF-7 cDNA library. To confirm the identity of the HET clone, we expressed a partial HET clone as a glutathione S-transferase fusion protein, and showed binding to the hsp27 promoter fragment in gel-retardation assays. The HET clone is almost identical to a recently published scaffold attachment factor (SAF-B) cloned from a HeLa cell cDNA library. Scaffold attachment factors are a subset of nuclear matrix proteins (NMP) that interact with matrix attachment regions. Analyzing how HET could act as a regulator of hsp27 transcription and as a SAF/NMP, we studied its subnuclear localization and its effect on hsp27 transcription in human breast cancer cells. We were able to show that HET is localized in the nuclear matrix in various breast cancer cell lines. Furthermore, in transient transfection assays using hsp27 promoter-luciferase reporter constructs, HET overexpression resulted in a dose-dependent decrease of hsp27 promoter activity in several cell lines.

  19. The protective effect of HET0016 on brain edema and blood-brain barrier dysfunction after cerebral ischemia/reperfusion.

    PubMed

    Liu, Yu; Wang, Di; Wang, Huan; Qu, Youyang; Xiao, Xingjun; Zhu, Yulan

    2014-01-28

    N-hydroxy-N-(4-butyl-2-methylphenyl) formamidine (HET0016) is a specific 20-hydroxyeicosatetraenoic acid (20-HETE) inhibitor which was first synthesized in 2001. It has been demonstrated that HET0016 reduces cerebral infarction volume in rat middle cerebral artery occlusion (MCAO) models. However, little is known about the role of HET0016 in the blood-brain barrier (BBB) dysfunction after cerebral ischemia/reperfusion (I/R) injury. The present study was designed to examine the effect of HET0016 in a MCAO and reperfusion rat model to determine whether it protects against brain edema and BBB disruption. Rats were subjected to 90 min MCAO, followed by 4, 24, 48, and 72 h reperfusion. Brain edema was measured according to the wet and dry weight method. BBB permeability based on the extravasation of Evans blue and sodium fluorescein was detected. BBB ultrastructure alterations were presented through transmission electron microscope. Superoxide production in ischemic tissue was also measured by dihydroethidium fluorescent probe. Western blot was used to analyze the expression of Claudin-5, ZO-1, MMP-9, and JNK pathway. At 24h after reperfusion, HET0016 reduced brain edema and BBB leakage. Ultrastructural damage of BBB and the increase of superoxide production were attenuated by HET0016 treatment. Western blot showed that HET0016 suppressed the activation of MMP-9 and JNK pathway but restored the expression of Claudin-5 and ZO-1. In conclusion, these results suggest that HET0016 protects BBB dysfunction after I/R by regulating the expression of MMP-9 and tight junction proteins. Furthermore, inhibition of oxidative stress and JNK pathway may be involved in this protecting effect.

  20. Woodwind Instrument Maintenance.

    ERIC Educational Resources Information Center

    Sperl, Gary

    1980-01-01

    The author presents a simple maintenance program for woodwind instruments which includes the care of tendon corks, the need for oiling keys, and methods of preventing cracks in woodwind instruments. (KC)

  1. Regional Instrumentation Centers.

    ERIC Educational Resources Information Center

    Cromie, William J.

    1980-01-01

    Focuses on the activities of regional instrumentation centers that utilize the state-of-the-art instruments and methodology in basic scientific research. The emphasis is on the centers involved in mass spectroscopy, magnetic resonance spectroscopy, lasers, and accelerators. (SA)

  2. Cognitive Ability and Whole-Body Rotation (Cognitief Vermogen en Rotatie van het Lichaam)

    DTIC Science & Technology

    1993-03-01

    unlimited. •If ". ,hA 2 CONTENTS Page SUMMARY 3 SAMENVATnING 4 1 GENERAL PROBLEM AREA 5 2 TASKS AND MOVEMENTS 5 3 PREVIOUS RESULTS FOR ACTIVE BODY...suggeree~n r. Het huidige experiment maakte gebruik van de gemotori- seerde draaistoel van bet IZF. Terwiji gedraaid werd voerden de proefpersonen een...processing, irrespective of content of cognitive processing (spatial or verbal- numerical). The interaction between body rotations and cognitive content

  3. The Instrumental Model

    ERIC Educational Resources Information Center

    Yeates, Devin Rodney

    2011-01-01

    The goal of this dissertation is to enable better predictive models by engaging raw experimental data through the Instrumental Model. The Instrumental Model captures the protocols and procedures of experimental data analysis. The approach is formalized by encoding the Instrumental Model in an XML record. Decoupling the raw experimental data from…

  4. Aeronautic Instruments. Section VI : Oxygen Instruments

    NASA Technical Reports Server (NTRS)

    Hunt, F L

    1923-01-01

    This report contains statements as to amount of oxygen required at different altitudes and the methods of storing oxygen. The two types of control apparatus - the compressed oxygen type and the liquid oxygen type - are described. Ten different instruments of the compressed type are described, as well as the foreign instruments of the liquid types. The performance and specifications and the results of laboratory tests on all representative types conclude this report.

  5. Review of Published Safety Thresholds for Human Divers Exposed to Underwater Sound (Veilige maximale geluidsniveaus voor duikers - beoordeling van publicaties)

    DTIC Science & Technology

    2008-04-01

    niveaus zi.in primair bedoeld your gebruik direct als gevolg van het geluid of als onderzocht welke publicatie de meCest in relatie tot militaire sonars...bet gebruik van In een eerder uitgevoerd intern TNO underwater your duikers. De meest explosieven, heiwerkzaamheden en kennisinvesteringsproject is... Contents M anagem entuittreksel ........................................................................................... 2 SIntroduction

  6. Early modern mathematical instruments.

    PubMed

    Bennett, Jim

    2011-12-01

    In considering the appropriate use of the terms "science" and "scientific instrument," tracing the history of "mathematical instruments" in the early modern period is offered as an illuminating alternative to the historian's natural instinct to follow the guiding lights of originality and innovation, even if the trail transgresses contemporary boundaries. The mathematical instrument was a well-defined category, shared across the academic, artisanal, and commercial aspects of instrumentation, and its narrative from the sixteenth to the eighteenth century was largely independent from other classes of device, in a period when a "scientific" instrument was unheard of.

  7. Laparoscopic dissecting instruments.

    PubMed

    Park, A E; Mastrangelo, M J; Gandsas, A; Chu, U; Quick, N E

    2001-03-01

    The authors provide an overview of laparoscopic dissecting instruments and discuss early development, surgical options, and special features. End effectors of different shapes and functions are described. A comparison of available energy sources for laparoscopic instruments includes discussion of thermal dissection, ultrasonic dissection, and water-jet dissection. The ergonomic risks and challenges inherent in the use of current laparoscopic instruments are outlined, as well as ergonomic issues for the design of future instruments. New directions that laparoscopic instrumentation may take are considered in connection with developing technology in robotics, haptic feedback, and MicroElectroMechanical Systems.

  8. High temperature geophysical instrumentation

    SciTech Connect

    Hardee, H.C.

    1988-06-01

    The instrumentation development program was to proceed in parallel with scientific research and was driven by the needs of researchers. The development of these instruments has therefore included numerous geophysical field tests, many of which have resulted in the publication of scientific articles. This paper is a brief summary of some of the major geophysical instruments that have been developed and tested under the High Temperature Geophysics Program. These instruments are briefly described and references are given for further detailed information and for scientific papers that have resulted from the use of these instruments. 9 refs., 14 figs.

  9. Seismic instrumentation of buildings

    USGS Publications Warehouse

    Çelebi, Mehmet

    2000-01-01

    The purpose of this report is to provide information on how and why we deploy seismic instruments in and around building structures. The recorded response data from buildings and other instrumented structures can be and are being primarily used to facilitate necessary studies to improve building codes and therefore reduce losses of life and property during damaging earthquakes. Other uses of such data can be in emergency response situations in large urban environments. The report discusses typical instrumentation schemes, existing instrumentation programs, the steps generally followed in instrumenting a structure, selection and type of instruments, installation and maintenance requirements and data retrieval and processing issues. In addition, a summary section on how recorded response data have been utilized is included. The benefits from instrumentation of structural systems are discussed.

  10. Present status of aircraft instruments

    NASA Technical Reports Server (NTRS)

    1932-01-01

    This report gives a brief description of the present state of development and of the performance characteristics of instruments included in the following group: speed instruments, altitude instruments, navigation instruments, power-plant instruments, oxygen instruments, instruments for aerial photography, fog-flying instruments, general problems, summary of instrument and research problems. The items considered under performance include sensitivity, scale errors, effects of temperature and pressure, effects of acceleration and vibration, time lag, damping, leaks, elastic defects, and friction.

  11. [Consequences of the new changes in Dutch spelling for the Nederlands Tijdschrift voor Geneeskunde].

    PubMed

    van Nimwegen, W J; Los, M L C; van den Eerenbeemt, A M M; Kabos, M

    2006-08-05

    At the end of 2005, a new edition of the Woordenlijst Nederlandse taal (List of words in the Dutch language, also referred to as the Green booklet) appeared with a few adjustments to the spelling changes implemented in 1995. These adjustments led to considerable excitement in the media. The new spelling rules and the new List of words have consequences for the style of the articles in the Nederlands Tijdschrift voor Geneeskunde (NTvG). The most important changes concern the use of lower case in combinations containing a proper name (for example, 'watson-jones-artrodese' instead of 'Watson-Jones-artrodese'). Certain abbreviations are also to be written in lower case from now on ('ecg' and 'hiv'). Finally, the rule for the intermediate 'n' in Dutch words such as 'paarde(n)bloem' has been reversed: one is now to write 'paarden-bloem' instead of' 'paardebloem'. Thanks to the greater availability of electronic spelling control programmes and the availability of all previous volumes of the NTvG in digital form, it will be easier for the authors of medico-scientific articles in the Dutch language to achieve a uniform spelling. The new rules were implemented officially on 1 August 2006.

  12. [An article for the Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine)?].

    PubMed

    van Gijn, J

    2001-01-06

    Original articles are the backbone of this journal, as with any scientific journal. The Nederlands Tijdschrift voor Geneeskunde stimulates submissions in this category of articles by offering an annual prize for young authors. On the other hand 30-40% of original articles has to be turned away by the editors, because of vital short-comings. The subject matter can be unsuitable, such as details about organisation of health care or a highly specialised topic. More often the methods are at fault. Common problems are: lack of a proper research question, result of medical or surgical treatment without a control group, use of a questionnaire, poor validity because of bias in selection of patients, circular reasoning in the assessment of a diagnostic test, or an inappropriate measure of outcome. We urge prospective authors to seek advice from a clinical epidemiologist or at least from a colleague with experience in clinical research before embarking on a clinical study. If such help is difficult to obtain the editors are prepared to act as intermediary between authors and methodological experts.

  13. [Reasons for rejection of articles vor publication in the Nederlands Tijdschrift voor Geneeskunde in 1990].

    PubMed

    Kan, C C; Lockefeer, J H; Overbeke, A J

    1991-05-11

    To deduce recommendations for authors which decrease the rejection probability we investigated retrospectively which reasons were mentioned in 1990 by the editorial board of the 'Nederlands Tijdschrift voor Geneeskunde' when it rejected original articles, reviews, clinical lessons and case reports, and whether length of the article, professional status of the first author, most relevant specialism and origin of the article influenced the rejection probability. Out of 547 articles 38% (208) were rejected; case reports were rejected most often (49%), reviews least often (33%). Peer review of original articles was the most thorough, of case studies the least. The most frequent reason for rejection in all categories was 'substantial shortcomings', particularly in the original articles (80%). Rejection of clinical lessons and case studies was relatively often due to criteria concerning the clinical message. Both rejected and accepted articles on average exceeded the length limit. Professional status and specialism were associated with a difference in rejection probability (chi 2, p less than 0.05). Specialists had the lowest rejection probability (31%). Nonspecialists benefited from specialist supervision. Articles originating from non-academic institutions were more often rejected than articles from academic centres. We advise authors to judge their articles by means of the criteria mentioned. Consultation of (methodological) experts, literature data bases, and (or) the editorial board can improve their chances. Non-specialists can benefit from the experience and expertise of specialists. In general, scientific attitude and willingness to alter the article according to editorial advice appear to have beneficial results.

  14. VIRUS instrument enclosures

    NASA Astrophysics Data System (ADS)

    Prochaska, T.; Allen, R.; Mondrik, N.; Rheault, J. P.; Sauseda, M.; Boster, E.; James, M.; Rodriguez-Patino, M.; Torres, G.; Ham, J.; Cook, E.; Baker, D.; DePoy, Darren L.; Marshall, Jennifer L.; Hill, G. J.; Perry, D.; Savage, R. D.; Good, J. M.; Vattiat, Brian L.

    2014-08-01

    The Visible Integral-Field Replicable Unit Spectrograph (VIRUS) instrument will be installed at the Hobby-Eberly Telescope† in the near future. The instrument will be housed in two enclosures that are mounted adjacent to the telescope, via the VIRUS Support Structure (VSS). We have designed the enclosures to support and protect the instrument, to enable servicing of the instrument, and to cool the instrument appropriately while not adversely affecting the dome environment. The system uses simple HVAC air handling techniques in conjunction with thermoelectric and standard glycol heat exchangers to provide efficient heat removal. The enclosures also provide power and data transfer to and from each VIRUS unit, liquid nitrogen cooling to the detectors, and environmental monitoring of the instrument and dome environments. In this paper, we describe the design and fabrication of the VIRUS enclosures and their subsystems.

  15. Review of Instrumented Indentation

    PubMed Central

    VanLandingham, Mark R.

    2003-01-01

    Instrumented indentation, also known as depth-sensing indentation or nanoindentation, is increasingly being used to probe the mechanical response of materials from metals and ceramics to polymeric and biological materials. The additional levels of control, sensitivity, and data acquisition offered by instrumented indentation systems have resulted in numerous advances in materials science, particularly regarding fundamental mechanisms of mechanical behavior at micrometer and even sub-micrometer length scales. Continued improvements of instrumented indentation testing towards absolute quantification of a wide range of material properties and behavior will require advances in instrument calibration, measurement protocols, and analysis tools and techniques. In this paper, an overview of instrumented indentation is given with regard to current instrument technology and analysis methods. Research efforts at the National Institute of Standards and Technology (NIST) aimed at improving the related measurement science are discussed. PMID:27413609

  16. Gemini Instrument Upgrade Program

    NASA Astrophysics Data System (ADS)

    Diaz, Ruben; Goodsell, Stephen; Kleinman, Scot

    2016-08-01

    The Gemini Observatory* remains committed to keeping its operational instrumentation competitive and serving the needs of its user community. Currently the observatory operates a 4 instruments + 1 AO system at each site. At Gemini North the GMOS-N, GNIRS, NIFS and NIRI instruments are offered supported by the ALTAIR AO system. In the south, GMOS-S, F-2, GPI and GSAOI are offered instrumentation and GeMS is the provided AO System. This paper reviews our strategy to keep our instrumentation suite competitive, examines both our current funded upgrade projects and our potential future enhancements. We summarize the work done and the results so far obtained within the instrument upgrade program.

  17. Wet chemistry instrument prototype

    NASA Technical Reports Server (NTRS)

    1974-01-01

    A wet chemistry instrument prototype for detecting amino acids in planetary soil samples was developed. The importance of amino acids and their condensation products to the development of life forms is explained. The characteristics of the instrument and the tests which were conducted to determine the materials compatibility are described. Diagrams are provided to show the construction of the instrument. Data obtained from the performance tests are reported.

  18. Aircrew Screening Instruments Review

    DTIC Science & Technology

    2007-09-01

    available tools . Several vendors indicated that they will have new selection instruments available within a few months. These are not listed. As noted...AFCAPS-FR-2011-0012 AIRCREW SCREENING INSTRUMENTS REVIEW Diane L. Damos Damos Aviation Services, Inc...June 2007 – August 2007 4. TITLE AND SUBTITLE Aircrew Screening Instruments Review 5a. CONTRACT NUMBER FA3089-06-F-0385 5b. GRANT NUMBER 5c

  19. Sterilization of Medical Instruments

    DTIC Science & Technology

    2007-05-06

    possible use with medical instruments and skin catheters. To address this challenge, MicroStructure Technologies (MicroST) is developing an...Project: DARPA - Sterilization of Medical Instruments Contract: # FA9550-06-C-0054 Principal Investigator: Joseph Birmingham Report: FINAL Report 1...as medical instruments and skin catheters. To address this challenge, MicroStructure Technologies (MicroST) is proposing a compact, low maintenance

  20. Alternative Policy Instruments

    DTIC Science & Technology

    1987-11-01

    CpRE CENTER FOR POLICY RESEARCH IN EDUCATION Alternative Policy o Instruments I Lorraine M. McDonnell Richard F. Elmore November 1987 DTICELECTE...03 Alternative Policy Instruments Lorraine M. McDonnell The RAND Corporation Richard F. Elmore Michigan State University November 1987 THRAND...range of policy instruments available or on the political and organizational conditions needed for each to work as intended. Policy decisions would

  1. Instrument validation project

    SciTech Connect

    Reynolds, B.A.; Daymo, E.A.; Geeting, J.G.H.; Zhang, J.

    1996-06-01

    Westinghouse Hanford Company Project W-211 is responsible for providing the system capabilities to remove radioactive waste from ten double-shell tanks used to store radioactive wastes on the Hanford Site in Richland, Washington. The project is also responsible for measuring tank waste slurry properties prior to injection into pipeline systems, including the Replacement of Cross-Site Transfer System. This report summarizes studies of the appropriateness of the instrumentation specified for use in Project W-211. The instruments were evaluated in a test loop with simulated slurries that covered the range of properties specified in the functional design criteria. The results of the study indicate that the compact nature of the baseline Project W-211 loop does not result in reduced instrumental accuracy resulting from poor flow profile development. Of the baseline instrumentation, the Micromotion densimeter, the Moore Industries thermocouple, the Fischer and Porter magnetic flow meter, and the Red Valve Pressure transducer meet the desired instrumental accuracy. An alternate magnetic flow meter (Yokagawa) gave nearly identical results as the baseline fischer and Porter. The Micromotion flow meter did not meet the desired instrument accuracy but could potentially be calibrated so that it would meet the criteria. The Nametre on-line viscometer did not meet the desired instrumental accuracy and is not recommended as a quantitative instrument although it does provide qualitative information. The recommended minimum set of instrumentation necessary to ensure the slurry meets the Project W-058 acceptance criteria is the Micromotion mass flow meter and delta pressure cells.

  2. Instrument performance evaluation

    SciTech Connect

    Swinth, K.L.

    1993-03-01

    Deficiencies exist in both the performance and the quality of health physics instruments. Recognizing the implications of such deficiencies for the protection of workers and the public, in the early 1980s the DOE and the NRC encouraged the development of a performance standard and established a program to test a series of instruments against criteria in the standard. The purpose of the testing was to establish the practicality of the criteria in the standard, to determine the performance of a cross section of available instruments, and to establish a testing capability. Over 100 instruments were tested, resulting in a practical standard and an understanding of the deficiencies in available instruments. In parallel with the instrument testing, a value-impact study clearly established the benefits of implementing a formal testing program. An ad hoc committee also met several times to establish recommendations for the voluntary implementation of a testing program based on the studies and the performance standard. For several reasons, a formal program did not materialize. Ongoing tests and studies have supported the development of specific instruments and have helped specific clients understand the performance of their instruments. The purpose of this presentation is to trace the history of instrument testing to date and suggest the benefits of a centralized formal program.

  3. Space applications instrumentation systems

    NASA Technical Reports Server (NTRS)

    Minzner, R. A.; Oberholtzer, J. D.

    1972-01-01

    A compendium of resumes of 158 instrument systems or experiments, of particular interest to space applications, is presented. Each resume exists in a standardized format, permitting entries for 26 administrative items and 39 scientific or engineering items. The resumes are organized into forty groups determined by the forty spacecraft with which the instruments are associated. The resumes are followed by six different cross indexes, each organized alphabetically according to one of the following catagories: instrument name, acronym, name of principal investigator, name of organization employing the principal investigator, assigned experiment number, and spacecraft name. The resumes are associated with a computerized instrument resume search and retrieval system.

  4. [Controlling instruments in radiology].

    PubMed

    Maurer, M

    2013-10-01

    Due to the rising costs and competitive pressures radiological clinics and practices are now facing, controlling instruments are gaining importance in the optimization of structures and processes of the various diagnostic examinations and interventional procedures. It will be shown how the use of selected controlling instruments can secure and improve the performance of radiological facilities. A definition of the concept of controlling will be provided. It will be shown which controlling instruments can be applied in radiological departments and practices. As an example, two of the controlling instruments, material cost analysis and benchmarking, will be illustrated.

  5. Who Do We Deploy for Psychological Operations: A Function Profile for TPT Members

    DTIC Science & Technology

    2008-01-01

    Nederlandse Organisatie voor toegepast-natuurwetenschappeljk TNO efe sle n V ilig eldonderzoek / Netherlands Organisation for Applied Scientific...tactical PSYOPS teams (TPT) te selecteren. van psychologische operaties bij’rNO te komen tot een competentieprotiel voor de Nederlandse TPT-leden. Bovendien...interviews met en competentieprofielen. verhoudingen (sensitieve/intuftieve Nederlandse militairen werkzaarn op het Het competentiegedeelte van het functie

  6. JBI instrumentation services

    NASA Astrophysics Data System (ADS)

    Muccio, M.; Lopez, E.; McKeel, R.

    2005-05-01

    The Joint Battlespace Infosphere (JBI) is an information management infrastructure that provides a basic set of flexible core services: publish, subscribe, and query. Managed Information Objects (MIOs) are published by JBI clients and are subsequently managed and disseminated to other subscribing JBI Clients by the JBI Core Services. MIOs can also be archived into a repository managed by the JBI Core Services upon publication and can later be queried for by JBI Clients. A reference implementation (RI) of the JBI Core Services using Java 2 Enterprise Edition (J2EE) technology is currently being developed at the Air Force Research Laboratory Information Directorate (AFRL/IF) in Rome, NY. JBI Instrumentation Services will allow users to gain insight into what activity is occurring inside the JBI Core Services. The phase 1 Instrumentation Services implementation has been developed as a standalone system that interacts with the JBI Core Services through a set of interfaces that provide a low impact, multi-implementation compatible connection. The Instrumentation Services Architecture makes use of the Instrumentation Entity Model to create entities that describe the real elements of the JBI Core Services: platforms, connections, users, nodes, and sequences. These entities populate the Instrumentation Space and are accessed by clients through the Instrumentation Client API (ICAPI). A web-based client that makes use of this ICAPI has been developed to visualize instrumentation information and demonstrate the capabilities of the Instrumentation Services. This client utilizes numerical rate graphs and dynamic graph trees to visualize JBI activity. This paper describes the phase 1 Instrumentation Services Architecture and development efforts involved in creating the JBI Instrumentation Services and prototype instrumentation client.

  7. Statistical analysis of the hen's egg test for micronucleus induction (HET-MN assay).

    PubMed

    Hothorn, Ludwig A; Reisinger, Kerstin; Wolf, Thorsten; Poth, Albrecht; Fieblinger, Dagmar; Liebsch, Manfred; Pirow, Ralph

    2013-09-18

    The HET-MN assay (hen's egg test for micronucleus induction) is different from other in vitro genotoxicity assays in that it includes toxicologically important features such as absorption, distribution, metabolic activation, and excretion of the test compound. As a promising follow-up to complement existing in vitro test batteries for genotoxicity, the HET-MN is currently undergoing a formal validation. To optimize the validation, the present study describes a critical analysis of previously obtained HET-MN data to check the experimental design and to identify the most appropriate statistical procedure to evaluate treatment effects. Six statistical challenges (I-VI) of general relevance were identified, and remedies were provided which can be transferred to similarly designed test methods: a Williams-type trend test is proposed for overdispersed counts (II) by means of a square-root transformation which is robust for small sample sizes (I), variance heterogeneity (III), and possible downturn effects at high doses (IV). Due to near-to-zero or even zero-count data occurring in the negative control (V), a conditional comparison of the treatment groups against the mean of the historical controls (VI) instead of the concurrent control was proposed, which is in accordance with US-FDA recommendations. For the modified Williams-type tests, the power can be estimated depending on the magnitude and shape of the trend, the number of dose groups, and the magnitude of the MN counts in the negative control. The experimental design used previously (i.e. six eggs per dose group, scoring of 1000 cells per egg) was confirmed. The proposed approaches are easily available in the statistical computing environment R, and the corresponding R-codes are provided.

  8. Instrumentation in endourology

    PubMed Central

    Khanna, Rakesh; Monga, Manoj

    2011-01-01

    Success with endourological procedures requires expertise and instrumentation. This review focuses on the instrumentation required for ureteroscopy and percutaneous nephrolithotomy, and provides a critical assessment of in vitro and clinical studies that have evaluated the comparative effectiveness of these medical devices. PMID:21904568

  9. Instrument for Curriculum Evaluation.

    ERIC Educational Resources Information Center

    Huetteman, Julie Doidge; Benson, RoseAnn

    A comprehensive Instrument for Curriculum Evaluation (ICE) was developed to qualitatively and quantitatively evaluate curriculum materials. The instrument contains 115 statements for assessing 11 aspects of curriculum: philosophy, needs assessment, theme, goals, learning objectives and standards, scope and sequence, field testing, instructor…

  10. Aeronautic Instruments. Section II : Altitude Instruments

    NASA Technical Reports Server (NTRS)

    Mears, A H; Henrickson, H B; Brombacher, W G

    1923-01-01

    This report is Section two of a series of reports on aeronautic instruments (Technical Report nos. 125 to 132, inclusive). This section discusses briefly barometric altitude determinations, and describes in detail the principal types of altimeters and barographs used in aeronautics during the recent war. This is followed by a discussion of performance requirements for such instruments and an account of the methods of testing developed by the Bureau of Standards. The report concludes with a brief account of the results of recent investigations. For accurate measurements of altitude, reference must also be made to thermometer readings of atmospheric temperature, since the altitude is not fixed by atmospheric pressure alone. This matter is discussed in connection with barometric altitude determination.

  11. The DKIST Instrumentation Suite

    NASA Astrophysics Data System (ADS)

    Woeger, Friedrich

    2016-05-01

    The Daniel K. Inouye Solar Telescope with its four meter diameter aperture will be the largest telescope in the world for solar observations when it is commissioned in the year 2019. In order to harness its scientific potential immediately, DKIST will integrate five instruments that each will provide unique functionality to measure properties of the solar atmosphere at unprecedented spatial resolution.In this paper we discuss the unique capabilities in the DKIST instrument suite that consists of the Visible Broadband Imager (VBI), the Visible Spectro-Polarimeter (ViSP), the Visible Tunable Filter (VTF), the Diffraction-Limited Near-Infrared Spectro-Polarimeter (DL-NIRSP), and the Cryogenic Near-Infrared Spectro-Polarimeter (Cryo-NIRSP).In addition, we will explain the facility's approach to supporting high spatial resolution data acquisition with multiple instruments simultaneously by means of the Facility Instrument Distribution Optics. This system of wavelength separating and interchangeable beamsplitters will enable a variety of different ways to optically configure the light beam to the instruments. This approach ensures that the DKIST instruments can use their individual advantages in a multitude of different observing scenarios. The DKIST instrumentation suite will enable crucial new insights into complex physical processes that occur on spatial scales that are smaller than any solar structure observed in the past.

  12. Instrument Attitude Precision Control

    NASA Technical Reports Server (NTRS)

    Juang, Jer-Nan

    2004-01-01

    A novel approach is presented in this paper to analyze attitude precision and control for an instrument gimbaled to a spacecraft subject to an internal disturbance caused by a moving component inside the instrument. Nonlinear differential equations of motion for some sample cases are derived and solved analytically to gain insight into the influence of the disturbance on the attitude pointing error. A simple control law is developed to eliminate the instrument pointing error caused by the internal disturbance. Several cases are presented to demonstrate and verify the concept presented in this paper.

  13. Wind instruments and headaches.

    PubMed

    Martínez-Lage, Juan F; Galarza, Marcelo; Pérez-Espejo, Miguel-Angel; López-Guerrero, Antonio L; Felipe-Murcia, Matías

    2013-03-01

    The authors illustrate the cases of two children with headaches, one diagnosed with Chiari type 1 malformation and the other with hydrocephalus, who played wind instruments. Both patients manifested that their headaches worsened with the efforts made during playing their musical instruments. We briefly comment on the probable role played by this activity on the patients' intracranial pressure and hypothesize that the headaches might be influenced by increases in their intracranial pressure related to Valsalva maneuvers. We had serious doubts on if we should advise our young patients about giving up playing their music instruments.

  14. Mass spectrometers: instrumentation

    NASA Astrophysics Data System (ADS)

    Cooks, R. G.; Hoke, S. H., II; Morand, K. L.; Lammert, S. A.

    1992-09-01

    Developments in mass spectrometry instrumentation over the past three years are reviewed. The subject is characterized by an enormous diversity of designs, a high degree of competition between different laboratories working with either different or similar techniques and by extremely rapid progress in improving analytical performance. Instruments can be grouped into genealogical charts based on their physical and conceptual interrelationships. This is illustrated using mass analyzers of different types. The time course of development of particular instrumental concepts is illustrated in terms of the s-curves typical of cell growth. Examples are given of instruments which are at the exponential, linear and mature growth stages. The prime examples used are respectively: (i) hybrid instruments designed to study reactive collisions of ions with surfaces: (ii) the Paul ion trap; and (iii) the triple quadrupole mass spectrometer. In the area of ion/surface collisions, reactive collisions such as hydrogen radical abstraction from the surface by the impinging ion are studied. They are shown to depend upon the chemical nature of the surface through the use of experiments which utilize self-assembled monolayers as surfaces. The internal energy deposited during surface-induced dissociation upon collision with different surfaces in a BEEQ instrument is also discussed. Attention is also given to a second area of emerging instrumentation, namely technology which allows mass spectrometers to be used for on-line monitoring of fluid streams. A summary of recent improvements in the performance of the rapidly developing quadrupole ion trap instrument illustrates this stage of instrument development. Improvements in resolution and mass range and their application to the characterization of biomolecules are described. The interaction of theory with experiment is illustrated through the role of simulations of ion motion in the ion trap. It is emphasized that mature instruments play a

  15. Aircraft Speed Instruments

    NASA Technical Reports Server (NTRS)

    Beij, K Hilding

    1933-01-01

    This report presents a concise survey of the measurement of air speed and ground speed on board aircraft. Special attention is paid to the pitot-static air-speed meter which is the standard in the United States for airplanes. Air-speed meters of the rotating vane type are also discussed in considerable detail on account of their value as flight test instruments and as service instruments for airships. Methods of ground-speed measurement are treated briefly, with reference to the more important instruments. A bibliography on air-speed measurement concludes the report.

  16. Testing Aircraft Instruments.

    DTIC Science & Technology

    1981-02-11

    AD-A095 680 ARMY TEST AND EVALUATION COMMAND ABERDEEN PROVING GRO--ETC F/S 1/4 TESTING AIRCRAFT INSTRUMENTS .(U) FEB 81 CLASSIFIED TOP-6-3-013 ML I...Test and Evaluation Command -?Final 7, Ts .to .. eg----- ( -4_ Fia - / + I ORG REPORT STesting Aircraft Instruments , j P I- I. AUTHOR(es) S. CONTRACT...Identify by block number) This document presents information and procedures for testing aircraft flight and systems performance instruments in the functional

  17. CALIPSO Instrument Operational

    Atmospheric Science Data Center

    2014-09-18

    CALIPSO Instrument Operational Thursday, September 11, 2014 The CALIPSO payload is back in data acquisition mode as of Wednesday, September 17, 2014.  CALIPSO data processing has returned to a nominal state, and...

  18. AIR Instrument Array

    NASA Technical Reports Server (NTRS)

    Jones, I. W.; Wilson, J. W.; Maiden, D. L.; Goldhagen, P.; Shinn, J. L.

    2003-01-01

    The large number of radiation types composing the atmospheric radiation requires a complicated combination of instrument types to fully characterize the environment. A completely satisfactory combination has not as yet been flown and would require a large capital outlay to develop. In that the funds of the current project were limited to essential integration costs, an international collaboration was formed with partners from six countries and fourteen different institutions with their own financial support for their participation. Instruments were chosen to cover sensitivity to all radiation types with enough differential sensitivity to separate individual components. Some instruments were chosen as important to specify the physical field component and other instruments were chosen on the basis that they could be useful in dosimetric evaluation. In the present paper we will discuss the final experimental flight package for the ER-2 flight campaign.

  19. Fiber Optics Instrumentation Development

    NASA Technical Reports Server (NTRS)

    Chan, Patrick Hon Man; Parker, Allen R., Jr.; Richards, W. Lance

    2010-01-01

    This is a general presentation of fiber optics instrumentation development work being conducted at NASA Dryden for the past 10 years and recent achievements in the field of fiber optics strain sensors.

  20. Low cost instrumentation amplifier

    NASA Technical Reports Server (NTRS)

    Sturman, J. C.

    1974-01-01

    Amplifier can be used for many applications requiring high input impedance and common mode rejection, low drift, and gain accuracy on order of one percent. Performance of inexpensive amplifier approaches that of some commercial instrumentation amplifiers in many specifications.

  1. NPP: The Five Instruments

    NASA Video Gallery

    The NPP satellite has 5 instruments on board: VIIRS, CERES, CrIS, ATMS, and OMPS. Each one will deliver a specific set of data helping weather prediction and climate studies. This video is a quick ...

  2. Instrumentation for Materials Research

    ERIC Educational Resources Information Center

    Claassen, Richard S.

    1976-01-01

    Discusses how sophisticated instrumentation techniques yield practical results in three typical materials problems: fracture analysis, joining, and compatibility. Describes techniques such as scanning and transmission electron microscopy, and Auger spectroscopy. (MLH)

  3. Cardiovascular instrumentation for spaceflight

    NASA Technical Reports Server (NTRS)

    Schappell, R. T.; Polhemus, J. T.; Ganiaris, N. J.

    1976-01-01

    The observation mechanisms dealing with pressure, flow, morphology, temperature, etc. are discussed. The approach taken in the performance of this study was to (1) review ground and space-flight data on cardiovascular function, including earlier related ground-based and space-flight animal studies, Mercury, Gemini, Apollo, Skylab, and recent bed-rest studies, (2) review cardiovascular measurement parameters required to assess individual performance and physiological alternations during space flight, (3) perform an instrumentation survey including a literature search as well as personal contact with the applicable investigators, (4) assess instrumentation applicability with respect to the established criteria, and (5) recommend future research and development activity. It is concluded that, for the most part, the required instrumentation technology is available but that mission-peculiar criteria will require modifications to adapt the applicable instrumentation to a space-flight configuration.

  4. IXO: The Instrument Complement

    NASA Astrophysics Data System (ADS)

    Nousek, John A.; IWG, IXO

    2009-01-01

    The International X-ray Observatory (IXO) has recently been created as a mission concept by a joint team of NASA, ESA and JAXA scientists, based on the previous Constellation-X and XEUS concepts. Definition of the IXO instruments is still under evolution, but the core instrument complement will include a Wide Field X-ray Imager, an X-ray Calorimeter / Narrow Field X-ray Imager, and an X-ray Grating Spectrometer. Other, modest additional instruments (such as a hard X-ray capability, a polarimeter, and a high time resolution detector) will also be considered. We present the current status of the IXO instrument complement and offer the opportunity for discussion of ideas relevant to the IXO mission concept process.

  5. Carbon Footprint Reduction Instruments

    EPA Pesticide Factsheets

    This page outlines the major differences between Renewable Energy Certificates (REC) and Project Offsets and what types of claims each instrument allows the organization to make in regards to environmental emissions claims.

  6. Mars Observer instrument complement

    NASA Astrophysics Data System (ADS)

    Komro, Fred G.; Hujber, Frank N.

    1991-10-01

    The mechanical and electrical characteristics and the functional designs of the eight scientific instruments of the Mars Observer's instrument complex are described, and their respective principal investigators and sponsoring institutions are listed. These instruments include a gamma-ray spectrometer, a magnetometer/electron reflectometer, the Mars balloon relay, the Mars Observer camera, the Mars Observer laser altimeter, a pressure modulator infrared radiometer, a thermal emission spectrometer, and an ultrastable oscillator. With these instruments, the Mars Observer will be able to determine the elemental and mineralogical character of Martial surface material; to define globally the topography and the gravitational field; to establish the nature of the magnetic field; to determine the spatial and temporal distribution abundances, sources, and sinks of volatile material and dust over a seasonal cycle; and to explore the structure and circulation of Martian atmosphere.

  7. TES Instrument Operational Status

    Atmospheric Science Data Center

    2017-02-26

    ... UPDATE: (1/24/2017)  The TES instrument metrology laser end of life testing that resumed on January 11, 2017 provided a gradual increase in the laser diode current. This increase has resulted in the restoration of the ...

  8. VIRUS instrument collimator assembly

    NASA Astrophysics Data System (ADS)

    Marshall, Jennifer L.; DePoy, Darren L.; Prochaska, Travis; Allen, Richard D.; Williams, Patrick; Rheault, Jean-Philippe; Li, Ting; Nagasawa, Daniel Q.; Akers, Christopher; Baker, David; Boster, Emily; Campbell, Caitlin; Cook, Erika; Elder, Alison; Gary, Alex; Glover, Joseph; James, Michael; Martin, Emily; Meador, Will; Mondrik, Nicholas; Rodriguez-Patino, Marisela; Villanueva, Steven; Hill, Gary J.; Tuttle, Sarah; Vattiat, Brian; Lee, Hanshin; Chonis, Taylor S.; Dalton, Gavin B.; Tacon, Mike

    2014-07-01

    The Visual Integral-Field Replicable Unit Spectrograph (VIRUS) instrument is a baseline array 150 identical fiber fed optical spectrographs designed to support observations for the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX). The collimator subassemblies of the instrument have been assembled in a production line and are now complete. Here we review the design choices and assembly practices used to produce a suite of identical low-cost spectrographs in a timely fashion using primarily unskilled labor.

  9. Advanced optical instruments technology

    NASA Technical Reports Server (NTRS)

    Shao, Mike; Chrisp, Michael; Cheng, Li-Jen; Eng, Sverre; Glavich, Thomas; Goad, Larry; Jones, Bill; Kaarat, Philip; Nein, Max; Robinson, William

    1992-01-01

    The science objectives for proposed NASA missions for the next decades push the state of the art in sensitivity and spatial resolution over a wide range of wavelengths, including the x-ray to the submillimeter. While some of the proposed missions are larger and more sensitive versions of familiar concepts, such as the next generation space telescope, others use concepts, common on the Earth, but new to space, such as optical interferometry, in order to provide spatial resolutions impossible with other concepts. However, despite their architecture, the performance of all of the proposed missions depends critically on the back-end instruments that process the collected energy to produce scientifically interesting outputs. The Advanced Optical Instruments Technology panel was chartered with defining technology development plans that would best improve optical instrument performance for future astrophysics missions. At this workshop the optical instrument was defined as the set of optical components that reimage the light from the telescope onto the detectors to provide information about the spatial, spectral, and polarization properties of the light. This definition was used to distinguish the optical instrument technology issues from those associated with the telescope, which were covered by a separate panel. The panel identified several areas for optical component technology development: diffraction gratings; tunable filters; interferometric beam combiners; optical materials; and fiber optics. The panel also determined that stray light suppression instruments, such as coronagraphs and nulling interferometers, were in need of general development to support future astrophysics needs.

  10. Medical instrument data exchange.

    PubMed

    Gumudavelli, Suman; McKneely, Paul K; Thongpithoonrat, Pongnarin; Gurkan, D; Chapman, Frank M

    2008-01-01

    Advances in medical devices and health care has been phenomenal during the recent years. Although medical device manufacturers have been improving their instruments, network connection of these instruments still rely on proprietary technologies. Even if the interface has been provided by the manufacturer (e.g., RS-232, USB, or Ethernet coupled with a proprietary API), there is no widely-accepted uniform data model to access data of various bedside instruments. There is a need for a common standard which allows for internetworking with the medical devices from different manufacturers. ISO/IEEE 11073 (X73) is a standard attempting to unify the interfaces of all medical devices. X73 defines a client access mechanism that would be implemented into the communication controllers (residing between an instrument and the network) in order to access/network patient data. On the other hand, MediCAN technology suite has been demonstrated with various medical instruments to achieve interfacing and networking with a similar goal in its open standardization approach. However, it provides a more generic definition for medical data to achieve flexibility for networking and client access mechanisms. In this paper, a comparison between the data model of X73 and MediCAN will be presented to encourage interoperability demonstrations of medical instruments.

  11. [The instrument for thermography].

    PubMed

    Hamaguchi, Shinsuke

    2014-07-01

    Thermography is an imaging method using the instrument to detect infrared rays emitted from the body surface, and to plot them as a distribution diagram of the temperature information. Therefore, a thermographic instrument can be assumed to measure the skin temperature of the diseased region. Such an instrument is a useful device for noninvasive and objective assessment of various diseases. Examination using a thermographic instrument can assess the autonomic dysfunction by measuring the skin blood flow involved with the sympathetic innervation. Thermography is useful in assisting the determination of the therapeutic effect. However, autonomic dysfunction should be confirmed correctly with the assessment of thermatome that shows abnormal thermal distribution in the region of the disease. Thermography should make noticeable the difference between the body temperature of abnormal and normal sites, and show the alteration of temperature. Monitoring using thermography is useful to determine the effect of sympathetic nerve block. If a thermographic instrument is used, it is important that examiners should understand the function of the instrument, as well as its advantages and disadvantages.

  12. Aeronautic Instruments. Section V : Power Plant Instruments

    NASA Technical Reports Server (NTRS)

    Washburn, G E; Sylvander, R C; Mueller, E F; Wilhelm, R M; Eaton, H N; Warner, John A C

    1923-01-01

    Part 1 gives a general discussion of the uses, principles, construction, and operation of airplane tachometers. Detailed description of all available instruments, both foreign and domestic, are given. Part 2 describes methods of tests and effect of various conditions encountered in airplane flight such as change of temperature, vibration, tilting, and reduced air pressure. Part 3 describes the principal types of distance reading thermometers for aircraft engines, including an explanation of the physical principles involved in the functioning of the instruments and proper filling of the bulbs. Performance requirements and testing methods are given and a discussion of the source of error and results of tests. Part 4 gives methods of tests and calibration, also requirements of gauges of this type for the pressure measurement of the air pressure in gasoline tanks and the engine oil pressure on airplanes. Part 5 describes two types of gasoline gauges, the float type and the pressure type. Methods of testing and calibrating gasoline depth gauges are given. The Schroeder, R. A. E., and the Mark II flowmeters are described.

  13. Harvesting the noncirculating pool of polymorphonuclear leukocytes in rats by hetastarch exchange transfusion (HET): yield and functional assessment

    SciTech Connect

    Williams, J.H. Jr.; Moser, K.M.; Ulich, T.; Cairo, M.S.

    1987-11-01

    Isolation of polymorphonuclear leukocytes (PMN) provides an opportunity to study PMN activity in vitro and to label PMN for study of in vivo kinetics. However, simple phlebotomy (SP) of a small animal frequently yields too few PMN for in vitro handling, while PMN harvested from an induced-peritonitis may not accurately reflect PMN in a less stimulated state. We report a novel method of harvesting PMN from the circulation of rats, using hetastarch exchange transfusion (HET), which is both time and animal sparing. HET harvested 8-fold more PMN than SP. In vitro cell function was examined with assays of adherence, chemotaxis, bacterial killing, and superoxide generation. No significant (p less than 0.05) difference was found between PMN obtained by HET and pooled-PMN obtained by SP. In vivo function was examined following labeling with indium 111-oxine. The kinetics pattern described suggested normal migratory activity when compared to previous reports. The data demonstrate that rats possess a relatively large, noncirculating pool of PMN which is readily accessible by HET.

  14. The heterocyst regulatory protein HetP and its homologs modulate heterocyst commitment in Anabaena sp. strain PCC 7120.

    PubMed

    Videau, Patrick; Rivers, Orion S; Hurd, Kathryn; Ushijima, Blake; Oshiro, Reid T; Ende, Rachel J; O'Hanlon, Samantha M; Cozy, Loralyn M

    2016-10-24

    The commitment of differentiating cells to a specialized fate is fundamental to the correct assembly of tissues within a multicellular organism. Because commitment is often irreversible, entry into and progression through this phase of development must be tightly regulated. Under nitrogen-limiting conditions, the multicellular cyanobacterium Anabaena sp. strain PCC 7120 terminally commits ∼10% of its cells to become specialized nitrogen-fixing heterocysts. Although commitment is known to occur 9-14 h after the induction of differentiation, the factors that regulate the initiation and duration of this phase have yet to be elucidated. Here, we report the identification of four genes that share a functional domain and modulate heterocyst commitment: hetP (alr2818), asl1930, alr2902, and alr3234 Epistatic relationships between all four genes relating to commitment were revealed by deleting them individually and in combination; asl1930 and alr3234 acted most upstream to delay commitment, alr2902 acted next in the pathway to inhibit development, and hetP acted most downstream to drive commitment forward. Possible protein-protein interactions between HetP, its homologs, and the heterocyst master regulator, HetR, were assessed, and interaction partners were defined. Finally, patterns of gene expression for each homolog, as determined by promoter fusions to gfp and reverse transcription-quantitative PCR, were distinct from that of hetP in both spatiotemporal organization and regulation. We posit that a dynamic succession of protein-protein interactions modulates the timing and efficiency of the commitment phase of development and note that this work highlights the utility of a multicellular cyanobacterium as a model for the study of developmental processes.

  15. The AFTA coronagraph instrument

    NASA Astrophysics Data System (ADS)

    Shaklan, Stuart; Levine, Marie; Foote, Marc; Rodgers, Michael; Underhill, Michael; Marchen, Luis; Klein, Dan

    2013-09-01

    The Astrophysics Focused Telescope Assets (AFTA) study in 2012-2013 included a high-contrast stellar coronagraph to complement the wide-field infrared survey (WFIRST) instrument. The idea of flying a coronagraph on this telescope was met with some skepticism because the AFTA pupil has a large central obscuration with six secondary mirror struts that impact the coronagraph sensitivity. However, several promising coronagraph concepts have emerged, and a corresponding initial instrument design has been completed. Requirements on the design include observations centered 0.6 deg off-axis, on-orbit robotic serviceability, operation in a geosynchronous orbit, and room-temperature operation (driven by the coronagraph's deformable mirrors). We describe the instrument performance requirements, the optical design, an observational scenario, and integration times for typical detection and characterization observations.

  16. Instrumentation at Gemini Observatory

    NASA Astrophysics Data System (ADS)

    Kleinman, S. J.; Boccas, Maxime; Goodsell, Stephen J.; Gomez, Percy; Murowinski, Rick; Chené, André-Nicolas; Henderson, David

    2014-07-01

    Gemini South's instrument suite has been completely transformed since our last biennial update. We commissioned the Gemini Multi-Conjugate Adaptive Optics System (GeMS) and its associated Gemini South Adaptive Optics Imager (GSAOI) as well as Flamingos-2, our long-slit and multi-object infrared imager and spectrograph, and the Gemini Planet Imager (GPI). We upgraded the CCDs in GMOS-S, our multi-object optical imager and spectrograph, with the GMOS-N CCD upgrade scheduled for 2015. Our next instrument, the Gemini High-resolution Optical SpecTrograph (GHOST) is in its preliminary design stage and we are making plans for the instrument to follow:Gen4#3.

  17. Nonmetallic Diaphragms for Instruments

    NASA Technical Reports Server (NTRS)

    Eaton, H N; Buckingham, C T

    1925-01-01

    This report, the second of a series of reports relating to the general subject of instrument diaphragms. The first report of the series was published as Technical Report no. 165, "diaphragms for aeronautic instruments," and comprised an outline of historical developments and theoretical principles. The present report relates entirely to nonmetallic diaphragms, the use of which in certain types of pressure elements has been increasing for some time. Little, if any, information has been available to aid the designer of instruments using this form of pressure element. It was to attempt to meet the need for such information that the investigation reported in this paper was undertaken. The report describes the various materials which have been used as nonmetallic diaphragms, discusses the factors which affect the performance of the diaphragms and gives the results of tests made for the purpose of investigating the effect produced by these factors.

  18. Micro mushroom instrumentation system

    NASA Astrophysics Data System (ADS)

    Davidson, W. F.

    1986-01-01

    An electronics circuit which provides for the recording of instrumentation data on an optical disk is disclosed. The optical disk is formatted in a spiral format instead of concentric tracks. The spiral format allows data to be recorded without the gaps that would be associated with concentric tracks. The instrumentation system provides each channel with a program instrumentation amplifier, a six pole lowpass switched capacitor filter, a sample and hold amplifier, and a digital to analog converter to provide automatic offset capability. Since each channel has its own components, simultaneous samples of every channel can be captured. All of the input signal's channel variables can be captured. All of the input signal's channel variables can be changed under software control without hardware changes. A single board computer is used for a system controller.

  19. Virtual Sensor Test Instrumentation

    NASA Technical Reports Server (NTRS)

    Wang, Roy

    2011-01-01

    Virtual Sensor Test Instrumentation is based on the concept of smart sensor technology for testing with intelligence needed to perform sell-diagnosis of health, and to participate in a hierarchy of health determination at sensor, process, and system levels. A virtual sensor test instrumentation consists of five elements: (1) a common sensor interface, (2) microprocessor, (3) wireless interface, (4) signal conditioning and ADC/DAC (analog-to-digital conversion/ digital-to-analog conversion), and (5) onboard EEPROM (electrically erasable programmable read-only memory) for metadata storage and executable software to create powerful, scalable, reconfigurable, and reliable embedded and distributed test instruments. In order to maximize the efficient data conversion through the smart sensor node, plug-and-play functionality is required to interface with traditional sensors to enhance their identity and capabilities for data processing and communications. Virtual sensor test instrumentation can be accessible wirelessly via a Network Capable Application Processor (NCAP) or a Smart Transducer Interlace Module (STIM) that may be managed under real-time rule engines for mission-critical applications. The transducer senses the physical quantity being measured and converts it into an electrical signal. The signal is fed to an A/D converter, and is ready for use by the processor to execute functional transformation based on the sensor characteristics stored in a Transducer Electronic Data Sheet (TEDS). Virtual sensor test instrumentation is built upon an open-system architecture with standardized protocol modules/stacks to interface with industry standards and commonly used software. One major benefit for deploying the virtual sensor test instrumentation is the ability, through a plug-and-play common interface, to convert raw sensor data in either analog or digital form, to an IEEE 1451 standard-based smart sensor, which has instructions to program sensors for a wide variety of

  20. Instrumentation Cables Test Plan

    SciTech Connect

    Muna, Alice Baca; LaFleur, Chris Bensdotter

    2016-10-01

    A fire at a nuclear power plant (NPP) has the potential to damage structures, systems, and components important to safety, if not promptly detected and suppressed. At Browns Ferry Nuclear Power Plant on March 22, 1975, a fire in the reactor building damaged electrical power and control systems. Damage to instrumentation cables impeded the function of both normal and standby reactor coolant systems, and degraded the operators’ plant monitoring capability. This event resulted in additional NRC involvement with utilities to ensure that NPPs are properly protected from fire as intended by the NRC principle design criteria (i.e., general design criteria 3, Fire Protection). Current guidance and methods for both deterministic and performance based approaches typically make conservative (bounding) assumptions regarding the fire-induced failure modes of instrumentation cables and those failure modes effects on component and system response. Numerous fire testing programs have been conducted in the past to evaluate the failure modes and effects of electrical cables exposed to severe thermal conditions. However, that testing has primarily focused on control circuits with only a limited number of tests performed on instrumentation circuits. In 2001, the Nuclear Energy Institute (NEI) and the Electric Power Research Institute (EPRI) conducted a series of cable fire tests designed to address specific aspects of the cable failure and circuit fault issues of concern1. The NRC was invited to observe and participate in that program. The NRC sponsored Sandia National Laboratories to support this participation, whom among other things, added a 4-20 mA instrumentation circuit and instrumentation cabling to six of the tests. Although limited, one insight drawn from those instrumentation circuits tests was that the failure characteristics appeared to depend on the cable insulation material. The results showed that for thermoset insulated cables, the instrument reading tended to drift

  1. Animation of MARDI Instrument

    NASA Technical Reports Server (NTRS)

    2008-01-01

    [figure removed for brevity, see original site] Click on image to view the animation

    This animation shows a zoom into the Mars Descent Imager (MARDI) instrument onboard NASA's Phoenix Mars Lander. The Phoenix team will soon attempt to use a microphone on the MARDI instrument to capture sounds of Mars.

    The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  2. Instrumentation in medical systems

    SciTech Connect

    Chu, W.T.

    1995-05-01

    The demand for clinical use of accelerated heavy charged-particle (proton and light-ion) beams for cancer treatment is now burgeoning worldwide. Clinical trials are underway at more than a dozen accelerators. Several hospital-based accelerator facilities dedicated to radiation treatment of human cancer have been constructed, and their number is growing. Many instruments in medical systems have been developed for modifying extracted particle beams for clinical application, monitoring the delivery of the treatment beams, and controlling the treatment processes to ensure patient safety. These in turn demand new developments of instruments in controlling beam extraction, beam tuning, and beam transportation at the medical systems.

  3. Microtechnology for instrumentation

    SciTech Connect

    Mariella, R.

    1998-01-01

    For the last two decades, the majority of research and development at LLNL in microtechnology has focused on photonics devices and bulk micromachining, including miccroelectro-mechanical systems and associated areas. For the last ten years, we have used these capabilities to address our analytical instrumentation needs. Just as the miniature photonics have enable the fabrication of analytical instruments that are either higher performance, smaller, more portable, or are combinations of these. Examples of these are our portable thermal cyclers for DNA analysis, our hand-held gas chromatograph, our flow-stream-waveguide-based flow cytometer, and our etched-microchannel electrophoresis systems. This presentation will describe these and related developments.

  4. Spectroelectrochemical Instrument Measures TOC

    NASA Technical Reports Server (NTRS)

    Kounaves, Sam

    2011-01-01

    A spectroelectrochemical instrument has been developed for measuring the total organic carbon (TOC) content of an aqueous solution. Measurements of TOC are frequently performed in environmental, clinical, and industrial settings. Until now, techniques for performing such measurements have included, various ly, the use of hazardous reagents, ultraviolet light, or ovens, to promote reactions in which the carbon contents are oxidized. The instrument now being developed is intended to be a safer, more economical means of oxidizing organic carbon and determining the TOC levels of aqueous solutions and for providing a low power/mass unit for use in planetary missions.

  5. Instrumentation in wind tunnels

    NASA Technical Reports Server (NTRS)

    Takashima, K.

    1986-01-01

    Requirements in designing instrumentation systems and measurements of various physical quantities in wind tunnels are surveyed. Emphasis is given to sensors used for measuring pressure, temperature, and angle, and the measurements of air turbulence and boundary layers. Instrumentation in wind tunnels require accuracy, fast response, diversity and operational simplicity. Measurements of force, pressure, attitude angle, free flow, pressure distribution, and temperature are illustrated by a table, and a block diagram. The LDV (laser Doppler velocimeter) method for measuring air turbulence and flow velocity and measurement of skin friction and flow fields using laser holograms are discussed. The future potential of these techniques is studied.

  6. Instrumental carbon monoxide dosimetry.

    PubMed

    Stetter, J R; Rutt, D R

    1980-10-01

    Modern technology for the ambient monitoring of carbon monoxide has been developed to produce a portable electrochemical instrument capable of the personal exposure to carbon monoxide. The performance characteristics of this device have been studied so that the unambiguous interpretation of field data could be performed. A study of the carbon monoxide exposure in a light manufacturing facility illustrate that effective dosimetry can be performed with expectations of accuracy typically better than +/- 15%, and that voluntary carbon monoxide exposures such as smoking were a significant contribution to the individual's exposure. Significant definition of the carbon monoxide exposure profile can be achieved with an instrument approach to the collection of the dosimetric data.

  7. High Efficiency Thermionics (HET-IV) and Converter Advancement (CAP) programs. Final reports

    SciTech Connect

    Geller, C.B.; Murray, C.S.; Riley, D.R.; Desplat, J.L.; Hansen, L.K.; Hatch, G.L.; McVey, J.B.; Rasor, N.S.

    1996-04-01

    This report contains the final report of the High Efficiency Thermionics (HET-IV) Program, Attachment A, performed at Rasor Associates, Inc. (RAI); and the final report of the Converter Advancement Program (CAP), performed at the Bettis Atomic Power Laboratory, Attachment B. The phenomenology of cesium-oxygen thermionic converters was elucidated in these programs, and the factors that had prevented the achievement of stable, enhanced cesium-oxygen converter performance for the previous thirty years were identified. Based on these discoveries, cesium-oxygen vapor sources were developed that achieved stable performance with factor-of-two improvements in power density and thermal efficiency, relative to conventional, cesium-only ignited mode thermionic converters. Key achievements of the HET-IV/CAP programs are as follows: a new technique for measuring minute traces of oxygen in cesium atmospheres; the determination of the proper range of oxygen partial pressures for optimum converter performance--10{sup {minus}7} to 10{sup {minus}9} torr; the discovery, and analysis of the cesium-oxygen liquid migration and compositional segregation phenomena; the successful use of capillary forces to contain the migration phenomenon; the use of differential heating to control compositional segregation, and induce vapor circulation; the development of mechanically and chemically stable, porous reservoir structures; the development of precise, in situ oxygen charging methods; stable improvements in emitter performance, up to effective emitter bare work functions of 5.4 eV; stable improvements in barrier index, to value below 1.8 Volts; the development of detailed microscopic models for cesium-oxygen reservoir dynamics and collector work function behavior; and the discovery of new relationships between electrode geometry and Schock Instability.

  8. Integrating Nephelometer Instrument Handbook

    SciTech Connect

    Uin, J.

    2016-03-01

    The Integrating Nephelometer (Figure 1) is an instrument that measures aerosol light scattering. It measures aerosol optical scattering properties by detecting (with a wide angular integration – from 7 to 170°) the light scattered by the aerosol and subtracting the light scattered by the carrier gas, the instrument walls and the background noise in the detector (zeroing). Zeroing is typically performed for 5 minutes every day at midnight UTC. The scattered light is split into red (700 nm), green (550 nm), and blue (450 nm) wavelengths and captured by three photomultiplier tubes. The instrument can measure total scatter as well as backscatter only (from 90 to 170°) (Heintzenberg and Charlson 1996; Anderson et al. 1996; Anderson and Ogren 1998; TSI 3563 2015) At ARM (Atmospheric Radiation Measurement), two identical Nephelometers are usually run in series with a sample relative humidity (RH) conditioner between them. This is possible because Nephelometer sampling is non-destructive and the sample can be passed on to another instrument. The sample RH conditioner scans through multiple RH values in cycles, treating the sample. This kind of setup allows to study how aerosol particles’ light scattering properties are affected by humidification (Anderson et al. 1996). For historical reasons, the two Nephelometers in this setup are labeled “wet” and “dry”, with the “dry” Nephelometer usually being the one before the conditioner and sampling ambient air (the names are switched for the MAOS measurement site due to the high RH of the ambient air).

  9. Portable dynamic fundus instrument

    NASA Technical Reports Server (NTRS)

    Taylor, Gerald R. (Inventor); Meehan, Richard T. (Inventor); Hunter, Norwood R. (Inventor); Caputo, Michael P. (Inventor); Gibson, C. Robert (Inventor)

    1992-01-01

    A portable diagnostic image analysis instrument is disclosed for retinal funduscopy in which an eye fundus image is optically processed by a lens system to a charge coupled device (CCD) which produces recordable and viewable output data and is simultaneously viewable on an electronic view finder. The fundus image is processed to develop a representation of the vessel or vessels from the output data.

  10. Music: Instrumental Techniques, Percussion.

    ERIC Educational Resources Information Center

    Pearl, Jesse

    A course in introduction to music emphasizing harmony is presented. The approach used is a laboratory approach in which pupils will develop skill in playing percussion instruments, sing, listen to, read and compose music with emphasis on elementary concepts of harmony. Course objectives include: (1) The student will recognize duple, triple,…

  11. Music: Instrumental Techniques, Strings.

    ERIC Educational Resources Information Center

    Ryan, Philip

    A course in music which emphasizes harmony is presented. The approach used is a laboratory one in which pupils will develop skill in playing orchestral string instruments, sing, listen to, read and compose music with emphasis on elementary concepts of harmony. Course objectives include: (1) The student will select the title of a familiar melody…

  12. Instrumentation Control Technician.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Center on Education and Training for Employment.

    This document contains 22 units to consider for use in a tech prep competency profile for the occupation of instrumentation control technician. All the units listed will not necessarily apply to every situation or tech prep consortium, nor will all the competencies within each unit be appropriate. Several units appear within each specific…

  13. Rain radar instrument definition

    NASA Astrophysics Data System (ADS)

    Vincent, Nicolas; Chenebault, J.; Suinot, Noel; Mancini, Paolo L.

    1996-12-01

    As a result of a pre-phase a study, founded by ESA, this paper presents the definition of a spaceborne Rain Radar, candidate instrument for earth explorer precipitation mission. Based upon the description of user requirements for such a dedicated mission, a mission analysis defines the most suitable space segment. At system level, a parametric analysis compares pros and cons of instrument concepts associated with rain rate retrieval algorithms in order to select the most performing one. Several trade-off analysis at subsystem level leads then to the definition of the proposed design. In particular, as pulse compression is implemented in order to increase the radar sensitivity, the selected method to achieve a pulse response with a side-lobe level below--60 dB is presented. Antenna is another critical rain radar subsystem and several designs are com pared: direct radiating array, single or dual reflector illuminated by single or dual feed arrays. At least, feasibility of centralized amplification using TWTA is compared with criticality of Tx/Rx modules for distributed amplification. Mass and power budgets of the designed instrument are summarized as well as standard deviations and bias of simulated rain rate retrieval profiles. The feasibility of a compliant rain radar instrument is therefore demonstrated.

  14. Neutron instrumentation for biology

    SciTech Connect

    Mason, S.A.

    1994-12-31

    In the October 1994 round of proposals at the ILL, the external biology review sub- committee was asked to allocate neutron beam time to a wide range of experiments, on almost half the total number of scheduled neutron instruments: on 3 diffractometers, on 3 small angle scattering instruments, and on some 6 inelastic scattering spectrometers. In the 3.5 years since the temporary reactor shutdown, the ILL`s management structure has been optimized, budgets and staff have been trimmed, the ILL reactor has been re-built, and many of the instruments up-graded, many powerful (mainly Unix) workstations have been introduced, and the neighboring European Synchrotron Radiation Facility has established itself as the leading synchrotron radiation source and has started its official user program. The ILL reactor remains the world`s most intense dedicated neutron source. In this challenging context, it is of interest to review briefly the park of ILL instruments used to study the structure and energetics of small and large biological systems. A brief summary will be made of each class of experiments actually proposed in the latest ILL proposal round.

  15. Process Instrumentation. Teacher Edition.

    ERIC Educational Resources Information Center

    Brown, A. O., III; Fowler, Malcolm

    This module provides instructional materials that are designed to help teachers train students in job skills for entry-level jobs as instrumentation technicians. This text addresses the basics of troubleshooting control loops, and the transducers, transmitters, signal conditioners, control valves, and controllers that enable process systems to…

  16. Instrument for assaying radiation

    DOEpatents

    Coleman, Jody Rustyn; Farfan, Eduardo B.

    2016-03-22

    An instrument for assaying radiation includes a flat panel detector having a first side opposed to a second side. A collimated aperture covers at least a portion of the first side of the flat panel detector. At least one of a display screen or a radiation shield may cover at least a portion of the second side of the flat panel detector.

  17. Instrument for Textbook Assessment.

    ERIC Educational Resources Information Center

    Huetteman, Julie Doidge

    An instrument to assist in assessing textbooks was created to provide a concise format for comparison and evaluation. Textbook characteristics were selected to illustrate content and proportion of characteristics of textbooks. Nine textbook characteristics were selected for quantifying the content areas of textbooks: (1) number of pages in the…

  18. AC resistance measuring instrument

    DOEpatents

    Hof, P.J.

    1983-10-04

    An auto-ranging AC resistance measuring instrument for remote measurement of the resistance of an electrical device or circuit connected to the instrument includes a signal generator which generates an AC excitation signal for application to a load, including the device and the transmission line, a monitoring circuit which provides a digitally encoded signal representing the voltage across the load, and a microprocessor which operates under program control to provide an auto-ranging function by which range resistance is connected in circuit with the load to limit the load voltage to an acceptable range for the instrument, and an auto-compensating function by which compensating capacitance is connected in shunt with the range resistance to compensate for the effects of line capacitance. After the auto-ranging and auto-compensation functions are complete, the microprocessor calculates the resistance of the load from the selected range resistance, the excitation signal, and the load voltage signal, and displays of the measured resistance on a digital display of the instrument. 8 figs.

  19. AC Resistance measuring instrument

    DOEpatents

    Hof, Peter J.

    1983-01-01

    An auto-ranging AC resistance measuring instrument for remote measurement of the resistance of an electrical device or circuit connected to the instrument includes a signal generator which generates an AC excitation signal for application to a load, including the device and the transmission line, a monitoring circuit which provides a digitally encoded signal representing the voltage across the load, and a microprocessor which operates under program control to provide an auto-ranging function by which range resistance is connected in circuit with the load to limit the load voltage to an acceptable range for the instrument, and an auto-compensating function by which compensating capacitance is connected in shunt with the range resistance to compensate for the effects of line capacitance. After the auto-ranging and auto-compensation functions are complete, the microprocessor calculates the resistance of the load from the selected range resistance, the excitation signal, and the load voltage signal, and displays of the measured resistance on a digital display of the instrument.

  20. HARMONI instrument control electronics

    NASA Astrophysics Data System (ADS)

    Gigante, José V.; Rodríguez Ramos, Luis F.; Zins, Gerard; Schnetler, Hermine; Pecontal, Arlette; Herreros, José Miguel; Clarke, Fraser; Bryson, Ian; Thatte, Niranjan

    2014-07-01

    HARMONI is an integral field spectrograph working at visible and near-infrared wavelengths over a range of spatial scales from ground layer corrected to fully diffraction-limited. The instrument has been chosen to be part of the first-light complement at the European Extremely Large Telescope (E-ELT). This paper describes the instrument control electronics to be developed at IAC. The large size of the HARMONI instrument, its cryogenic operation, and the fact that it must operate with enhanced reliability is a challenge from the point of view of the control electronics design. The present paper describes a design proposal based on the current instrument requirements and intended to be fully compliant with the ESO E-ELT standards, as well as with the European EMC and safety standards. The modularity of the design and the use of COTS standard hardware will benefit the project in several aspects, as reduced costs, shorter schedule by the use of commercially available components, and improved quality by the use of well proven solutions.

  1. Elementary Instrumental Music Program.

    ERIC Educational Resources Information Center

    Smith, Dolores A.

    THE FOLLOWING IS THE FULL TEXT OF THIS DOCUMENT: Our former Elementary Instrumental Music Program for 4th-6th graders was costly and ineffective. Students were bused to a high school in the middle of the instructional day--costs (time and transportation) were not compensatory with the program, which was experiencing a significant drop-out rate.…

  2. Music: Instrumental Techniques, Woodwinds.

    ERIC Educational Resources Information Center

    Baker, Melvin

    A course in introduction to music emphasizing modes and forms is presented. The approach used is a laboratory approach in which pupils will develop skill in playing wood-wind instruments, sing, listen to, read and compose music with emphasis on identification of elementary concepts of mode and form. Course objectives include: (1) pupil will select…

  3. Ozone monitoring instrument (OMI)

    NASA Astrophysics Data System (ADS)

    de Vries, Johan; van den Oord, Gijsbertus H. J.; Hilsenrath, Ernest; te Plate, Maurice B.; Levelt, Pieternel F.; Dirksen, Ruud

    2002-01-01

    The Ozone Monitoring Instrument (OMI) is an UV-Visible imaging spectrograph using two dimensional CCD detectors to register both the spectrum and the swath perpendicular to the flight direction. This allows having a wide swath (114 degrees) combined with a small ground pixel (nominally 13 x 24 km). The instrument is planned for launch on NASA's EOS-AURA satellite in June 2003. Currently the OMI Flight Model is being build. This shortly follows the Instrument Development Model (DM) which was built to, next to engineering purposes, verify the instrument performance. The paper presents measured results from this DM for optical parameters such as distortion, optical efficiency, stray light and polarization sensitivity. Distortion in the spatial direction is shown to be on sub-pixel level and the stray light levels are very low and almost free from ghost peaks. The polarization sensitivity is presently demonstrated to be below 10-3 but we aim to lower the detection limit by an order of magnitude to make sure that spectral residuals do not mix with trace gas absorption spectra. Critical detector parameters are presented such as the very high UV quantum efficiency (60 % at 270 nm), dark current behavior and the sensitivity to radiation.

  4. Scatterometry

    NASA Astrophysics Data System (ADS)

    Stoffelen, Adrianus Cornelis Maria

    1996-10-01

    Een veelheid aan meteorologische metingen is dagelijks beschikbaar. De meeste van deze waarnemingen bevinden zich echter boven land, en met name windwaarnemingen boven de (Noord Atlantische) oceaan zijn schaars. Bij een westelijke luchtstroming is dit een duidelijke beperking voor de weers- en golfverwachtingen ten behoeve van Nederland. Juist dan is het gevaar voor bijvoorbeeld storm of overstroming het grootst. Ook in het aardse klimaatsysteem speelt de wind aan het oppervlak een grote rol en is de belangrijkste factor voor de aandrijving van de oceaancirculatie. De oceaancirculatie op zijn beurt is cruciaal voor de verschijnselen die samenhangen met bijvoorbeeld El Niño. Dit proefschift gaat over het scatterometer instrument dat vanuit de ruimte, zelfs onder een wolkendek, nauwkeurige en betrouwbare informatie geeft over de wind aan het oceaanoppervlak met een hoge mate van ruimtelijke consistentie. Tijdens de tweede wereldoorlog werden radars aan boord van schepen veelvuldig gebruikt voor de opsporing van vijandige vaartuigen. Hierbij werd vastgesteld dat de detectie slechter werd naarmate de wind aan het zeeoppervlak groter was. Proefondervindelijk was hiermee het principe van een wind scatterometer aangetoond. Al snel ontwikkelde zich dan ook de idee de wind aan het zeeoppervlak te meten met behulp van radar. Vanuit een vliegtuig of een satelliet word dan een microgolfbundel onder een schuine hoek naar het zeeoppervlak gestuurd. De microgolfstraling, met gewoonlijk een golflengte van enkele centimeters, wordt verstrooid aan het ruwe oppervlak, en een klein gedeelte van de uitgezonden puls keert terug naar het detectorgedeelte van de scatterometer. Het fysische fenomeen van belang voor de werking van de scatterometer is de aanwezigheid van zogeheten capillaire gavitatiegolven op het zeeoppervlak. Deze golven hebben een golflengte van enkele centimeters en reageren vrijwel instantaan op de sterkte van de wind. De verstrooiing van microgolven is op zijn beurt

  5. Subcellular localization and clues for the function of the HetN factor influencing heterocyst distribution in Anabaena sp. strain PCC 7120.

    PubMed

    Corrales-Guerrero, Laura; Mariscal, Vicente; Nürnberg, Dennis J; Elhai, Jeff; Mullineaux, Conrad W; Flores, Enrique; Herrero, Antonia

    2014-10-01

    In the filamentous cyanobacterium Anabaena sp. strain PCC 7120, heterocysts are formed in the absence of combined nitrogen, following a specific distribution pattern along the filament. The PatS and HetN factors contribute to the heterocyst pattern by inhibiting the formation of consecutive heterocysts. Thus, inactivation of any of these factors produces the multiple contiguous heterocyst (Mch) phenotype. Upon N stepdown, a HetN protein with its C terminus fused to a superfolder version of green fluorescent protein (sf-GFP) or to GFP-mut2 was observed, localized first throughout the whole area of differentiating cells and later specifically on the peripheries and in the polar regions of mature heterocysts, coinciding with the location of the thylakoids. Polar localization required an N-terminal stretch comprising residues 2 to 27 that may represent an unconventional signal peptide. Anabaena strains expressing a version of HetN lacking this fragment from a mutant gene placed at the native hetN locus exhibited a mild Mch phenotype. In agreement with previous results, deletion of an internal ERGSGR sequence, which is identical to the C-terminal sequence of PatS, also led to the Mch phenotype. The subcellular localization in heterocysts of fluorescence resulting from the fusion of GFP to the C terminus of HetN suggests that a full HetN protein is present in these cells. Furthermore, the full HetN protein is more conserved among cyanobacteria than the internal ERGSGR sequence. These observations suggest that HetN anchored to thylakoid membranes in heterocysts may serve a function besides that of generating a regulatory (ERGSGR) peptide.

  6. netherland hydrological modeling instrument

    NASA Astrophysics Data System (ADS)

    Hoogewoud, J. C.; de Lange, W. J.; Veldhuizen, A.; Prinsen, G.

    2012-04-01

    Netherlands Hydrological Modeling Instrument A decision support system for water basin management. J.C. Hoogewoud , W.J. de Lange ,A. Veldhuizen , G. Prinsen , The Netherlands Hydrological modeling Instrument (NHI) is the center point of a framework of models, to coherently model the hydrological system and the multitude of functions it supports. Dutch hydrological institutes Deltares, Alterra, Netherlands Environmental Assessment Agency, RWS Waterdienst, STOWA and Vewin are cooperating in enhancing the NHI for adequate decision support. The instrument is used by three different ministries involved in national water policy matters, for instance the WFD, drought management, manure policy and climate change issues. The basis of the modeling instrument is a state-of-the-art on-line coupling of the groundwater system (MODFLOW), the unsaturated zone (metaSWAP) and the surface water system (MOZART-DM). It brings together hydro(geo)logical processes from the column to the basin scale, ranging from 250x250m plots to the river Rhine and includes salt water flow. The NHI is validated with an eight year run (1998-2006) with dry and wet periods. For this run different parts of the hydrology have been compared with measurements. For instance, water demands in dry periods (e.g. for irrigation), discharges at outlets, groundwater levels and evaporation. A validation alone is not enough to get support from stakeholders. Involvement from stakeholders in the modeling process is needed. There fore to gain sufficient support and trust in the instrument on different (policy) levels a couple of actions have been taken: 1. a transparent evaluation of modeling-results has been set up 2. an extensive program is running to cooperate with regional waterboards and suppliers of drinking water in improving the NHI 3. sharing (hydrological) data via newly setup Modeling Database for local and national models 4. Enhancing the NHI with "local" information. The NHI is and has been used for many

  7. REMOTE LAND MINE(FIELD) DETECTION. An Overview of Techniques (DETECTIE VAN LANDMIJNEN EN MIJNENVELDEN OP AFSTAND. Een Overzicht van de technieken),

    DTIC Science & Technology

    1994-09-01

    systeem voor mijnen of mijnenvelden essentieel. De basis principes en sterke en zwakke punten van "real time" mijnen detectie met visuele, nabij...tweede deel van het rapport worden aanbevelingen gegeven voor een toekomstig systeem voor de detectie van mijnen. Deze aanbevelingen zijn gebaseerd...multi-sensor systeem voor op een voertuig. Dit is gebaseerd op de interesse die de "Genie" toont voor een dergelijk systeem , de kosten van een

  8. Instrument techniques for rheometry

    NASA Astrophysics Data System (ADS)

    Hou, Ying Y.; Kassim, Hamida O.

    2005-10-01

    This article presents a review of some latest advances in rheology measuring techniques. Consideration is given to the modification and approaches in conventional measuring techniques and also to the development of specialty instruments. A number of sensing technologies such as nuclear-magnetic-resonance imaging and ultrasonic pulse Doppler mapping have recently been adopted to produce viscoelastic measurements for both Newtonian and non-Newtonian materials. The working principles of these technologies and their applications are described. Other recent developments in modifications of conventional rheometers for performance enhancement and for complex material characterizations have been thoroughly discussed. Some instrument designs and their special applications, such as interfacial rheometers, extensional rheometers, and high-pressure rheometers, have also been evaluated in detail.

  9. Data acquisition instruments: Psychopharmacology

    SciTech Connect

    Hartley, D.S. III

    1998-01-01

    This report contains the results of a Direct Assistance Project performed by Lockheed Martin Energy Systems, Inc., for Dr. K. O. Jobson. The purpose of the project was to perform preliminary analysis of the data acquisition instruments used in the field of psychiatry, with the goal of identifying commonalities of data and strategies for handling and using the data in the most advantageous fashion. Data acquisition instruments from 12 sources were provided by Dr. Jobson. Several commonalities were identified and a potentially useful data strategy is reported here. Analysis of the information collected for utility in performing diagnoses is recommended. In addition, further work is recommended to refine the commonalities into a directly useful computer systems structure.

  10. Instrumentation for Mars Environments

    NASA Technical Reports Server (NTRS)

    Landis, Geoffrey A.

    1997-01-01

    The main portion of the project was to support the "MAE" experiment on the Mars Pathfinder mission and to design instrumentation for future space missions to measure dust deposition on Mars and to characterize the properties of the dust. A second task was to analyze applications for photovoltaics in new space environments, and a final task was analysis of advanced applications for solar power, including planetary probes, photovoltaic system operation on Mars, and satellite solar power systems.

  11. Computers in Scientific Instrumentation.

    DTIC Science & Technology

    1982-01-13

    The CPU bus Attachment. In the first applications or d 4ata are connected to the central ues parallel digital lines for data an computers to...simple function se- Mg on ae results of its previous opera- designing instruments that can provide hotios by being directly labeled for the ties. In...that the signal from the sensor is with an operating system is powerful , that might be found in appropriately pro- interpretable to give the sought- for

  12. Frontiers of accelerator instrumentation

    SciTech Connect

    Ross, M.

    1992-08-01

    New technology has permitted significant performance improvements of established instrumentation techniques including beam position and profile monitoring. Fundamentally new profile monitor strategies are required for the next generation of accelerators, especially linear colliders (LC). Beams in these machines may be three orders of magnitude smaller than typical beams in present colliders. In this paper we review both the present performance levels achieved by conventional systems and present some new ideas for future colliders.

  13. Mandolin Family Instruments

    NASA Astrophysics Data System (ADS)

    Cohen, David J.; Rossing, Thomas D.

    The mandolin family of instruments consists of plucked chordophones, each having eight strings in four double courses. With the exception of the mandobass, the courses are tuned in intervals of fifths, as are the strings in violin family instruments. The soprano member of the family is the mandolin, tuned G3-D4-A4-E5. The alto member of the family is the mandola, tuned C3-G3-D4-A4. The mandola is usually referred to simply as the mandola in the USA, but is called the tenor mandola in Europe. The tenor member of the family is the octave mandolin, tuned G2-D3-A3-E4. It is referred to as the octave mandolin in the USA, and as the octave mandola in Europe. The baritone member of the family is the mandocello, or mandoloncello, tuned C2-G2-D3-A3. A variant of the mandocello not common in the USA is the five-course liuto moderno, or simply liuto, designed for solo repertoire. Its courses are tuned C2-G2-D3-A3-E4. A mandobass was also made by more than one manufacturer during the early twentieth century, though none are manufactured today. They were fretted instruments with single string courses tuned E1-A1-D2-G2. There are currently a few luthiers making piccolo mandolins, tuned C4-G4-D5-A5.

  14. An ice lithography instrument.

    PubMed

    Han, Anpan; Chervinsky, John; Branton, Daniel; Golovchenko, J A

    2011-06-01

    We describe the design of an instrument that can fully implement a new nanopatterning method called ice lithography, where ice is used as the resist. Water vapor is introduced into a scanning electron microscope (SEM) vacuum chamber above a sample cooled down to 110 K. The vapor condenses, covering the sample with an amorphous layer of ice. To form a lift-off mask, ice is removed by the SEM electron beam (e-beam) guided by an e-beam lithography system. Without breaking vacuum, the sample with the ice mask is then transferred into a metal deposition chamber where metals are deposited by sputtering. The cold sample is then unloaded from the vacuum system and immersed in isopropanol at room temperature. As the ice melts, metal deposited on the ice disperses while the metals deposited on the sample where the ice had been removed by the e-beam remains. The instrument combines a high beam-current thermal field emission SEM fitted with an e-beam lithography system, cryogenic systems, and a high vacuum metal deposition system in a design that optimizes ice lithography for high throughput nanodevice fabrication. The nanoscale capability of the instrument is demonstrated with the fabrication of nanoscale metal lines.

  15. An ice lithography instrument

    SciTech Connect

    Han, Anpan; Chervinsky, John; Branton, Daniel; Golovchenko, J. A.

    2011-06-15

    We describe the design of an instrument that can fully implement a new nanopatterning method called ice lithography, where ice is used as the resist. Water vapor is introduced into a scanning electron microscope (SEM) vacuum chamber above a sample cooled down to 110 K. The vapor condenses, covering the sample with an amorphous layer of ice. To form a lift-off mask, ice is removed by the SEM electron beam (e-beam) guided by an e-beam lithography system. Without breaking vacuum, the sample with the ice mask is then transferred into a metal deposition chamber where metals are deposited by sputtering. The cold sample is then unloaded from the vacuum system and immersed in isopropanol at room temperature. As the ice melts, metal deposited on the ice disperses while the metals deposited on the sample where the ice had been removed by the e-beam remains. The instrument combines a high beam-current thermal field emission SEM fitted with an e-beam lithography system, cryogenic systems, and a high vacuum metal deposition system in a design that optimizes ice lithography for high throughput nanodevice fabrication. The nanoscale capability of the instrument is demonstrated with the fabrication of nanoscale metal lines.

  16. Instrumentation and diagnostics

    SciTech Connect

    Nakaishi, C.V.; Bedick, R.C.

    1990-12-01

    This Technology Status Report describes research and accomplishments for the Instrumentation and Diagnostics (I D) Projects within the Advanced Research and Technology Development (AR TD) Program of the United States Department of Energy (DOE) Office of Fossil Energy (FE). Process understanding and control can be improved through the development of advanced instrumentation and diagnostics. The thrust of the I D Projects is to further develop existing measurement and control techniques for application to advanced coal-based technologies. Project highlights are: an inductively coupled plasma (ICP) instrument has been developed to analyze trace elements in gasification and combustion process streams. An in situ two-color Mie scattering technique with LSS can simultaneously measure the size, velocity, and elemental composition of coal particles during combustion. A high-temperature, fluorescence thermometry technique has accurately measured gas temperatures during field testing in combustion and gasification environments. Expert systems have been developed to improve the control of advanced coal-based processes. Capacitance flowmeters were developed to determine the mass flowrate, solid volume fraction, and particle velocities of coal slurries. 32 refs., 9 figs.

  17. FHR Process Instruments

    SciTech Connect

    Holcomb, David Eugene

    2015-01-01

    Fluoride salt-cooled High temperature Reactors (FHRs) are entering into early phase engineering development. Initial candidate technologies have been identified to measure all of the required process variables. The purpose of this paper is to describe the proposed measurement techniques in sufficient detail to enable assessment of the proposed instrumentation suite and to support development of the component technologies. This paper builds upon the instrumentation chapter of the recently published FHR technology development roadmap. Locating instruments outside of the intense core radiation and high-temperature fluoride salt environment significantly decreases their environmental tolerance requirements. Under operating conditions, FHR primary coolant salt is a transparent, low-vapor-pressure liquid. Consequently, FHRs can employ standoff optical measurements from above the salt pool to assess in-vessel conditions. For example, the core outlet temperature can be measured by observing the fuel s blackbody emission. Similarly, the intensity of the core s Cerenkov glow indicates the fission power level. Short-lived activation of the primary coolant provides another means for standoff measurements of process variables. The primary coolant flow and neutron flux can be measured using gamma spectroscopy along the primary coolant piping. FHR operation entails a number of process measurements. Reactor thermal power and core reactivity are the most significant variables for process control. Thermal power can be determined by measuring the primary coolant mass flow rate and temperature rise across the core. The leading candidate technologies for primary coolant temperature measurement are Au-Pt thermocouples and Johnson noise thermometry. Clamp-on ultrasonic flow measurement, that includes high-temperature tolerant standoffs, is a potential coolant flow measurement technique. Also, the salt redox condition will be monitored as an indicator of its corrosiveness. Both

  18. Topics in Chemical Instrumentation, Cl. Thermoluminescence: Part II. Instrumentation.

    ERIC Educational Resources Information Center

    Manche, Emanuel P.

    1979-01-01

    Presents part two on the use of the detection of thermoluminescence as an analytical tool for the chemistry laboratory and allied science. This part discusses instrumentation used and investigates recent developments in instrumentation for thermoluminescence. (HM)

  19. CARMENES instrument overview

    NASA Astrophysics Data System (ADS)

    Quirrenbach, A.; Amado, P. J.; Caballero, J. A.; Mundt, R.; Reiners, A.; Ribas, I.; Seifert, W.; Abril, M.; Aceituno, J.; Alonso-Floriano, F. J.; Ammler-von Eiff, M.; Antona Jiménez, R.; Anwand-Heerwart, H.; Azzaro, M.; Bauer, F.; Barrado, D.; Becerril, S.; Béjar, V. J. S.; Benítez, D.; Berdiñas, Z. M.; Cárdenas, M. C.; Casal, E.; Claret, A.; Colomé, J.; Cortés-Contreras, M.; Czesla, S.; Doellinger, M.; Dreizler, S.; Feiz, C.; Fernández, M.; Galadí, D.; Gálvez-Ortiz, M. C.; García-Piquer, A.; García-Vargas, M. L.; Garrido, R.; Gesa, L.; Gómez Galera, V.; González Álvarez, E.; González Hernández, J. I.; Grözinger, U.; Guàrdia, J.; Guenther, E. W.; de Guindos, E.; Gutiérrez-Soto, J.; Hagen, H.-J.; Hatzes, A. P.; Hauschildt, P. H.; Helmling, J.; Henning, T.; Hermann, D.; Hernández Castaño, L.; Herrero, E.; Hidalgo, D.; Holgado, G.; Huber, A.; Huber, K. F.; Jeffers, S.; Joergens, V.; de Juan, E.; Kehr, M.; Klein, R.; Kürster, M.; Lamert, A.; Lalitha, S.; Laun, W.; Lemke, U.; Lenzen, R.; López del Fresno, Mauro; López Martí, B.; López-Santiago, J.; Mall, U.; Mandel, H.; Martín, E. L.; Martín-Ruiz, S.; Martínez-Rodríguez, H.; Marvin, C. J.; Mathar, R. J.; Mirabet, E.; Montes, D.; Morales Muñoz, R.; Moya, A.; Naranjo, V.; Ofir, A.; Oreiro, R.; Pallé, E.; Panduro, J.; Passegger, V.-M.; Pérez-Calpena, A.; Pérez Medialdea, D.; Perger, M.; Pluto, M.; Ramón, A.; Rebolo, R.; Redondo, P.; Reffert, S.; Reinhardt, S.; Rhode, P.; Rix, H.-W.; Rodler, F.; Rodríguez, E.; Rodríguez-López, C.; Rodríguez-Pérez, E.; Rohloff, R.-R.; Rosich, A.; Sánchez-Blanco, E.; Sánchez Carrasco, M. A.; Sanz-Forcada, J.; Sarmiento, L. F.; Schäfer, S.; Schiller, J.; Schmidt, C.; Schmitt, J. H. M. M.; Solano, E.; Stahl, O.; Storz, C.; Stürmer, J.; Suárez, J. C.; Ulbrich, R. G.; Veredas, G.; Wagner, K.; Winkler, J.; Zapatero Osorio, M. R.; Zechmeister, M.; Abellán de Paco, F. J.; Anglada-Escudé, G.; del Burgo, C.; Klutsch, A.; Lizon, J. L.; López-Morales, M.; Morales, J. C.; Perryman, M. A. C.; Tulloch, S. M.; Xu, W.

    2014-07-01

    This paper gives an overview of the CARMENES instrument and of the survey that will be carried out with it during the first years of operation. CARMENES (Calar Alto high-Resolution search for M dwarfs with Exoearths with Near-infrared and optical Echelle Spectrographs) is a next-generation radial-velocity instrument under construction for the 3.5m telescope at the Calar Alto Observatory by a consortium of eleven Spanish and German institutions. The scientific goal of the project is conducting a 600-night exoplanet survey targeting ~ 300 M dwarfs with the completed instrument. The CARMENES instrument consists of two separate echelle spectrographs covering the wavelength range from 0.55 to 1.7 μm at a spectral resolution of R = 82,000, fed by fibers from the Cassegrain focus of the telescope. The spectrographs are housed in vacuum tanks providing the temperature-stabilized environments necessary to enable a 1 m/s radial velocity precision employing a simultaneous calibration with an emission-line lamp or with a Fabry-Perot etalon. For mid-M to late-M spectral types, the wavelength range around 1.0 μm (Y band) is the most important wavelength region for radial velocity work. Therefore, the efficiency of CARMENES has been optimized in this range. The CARMENES instrument consists of two spectrographs, one equipped with a 4k x 4k pixel CCD for the range 0.55 - 1.05 μm, and one with two 2k x 2k pixel HgCdTe detectors for the range from 0.95 - 1.7μm. Each spectrograph will be coupled to the 3.5m telescope with two optical fibers, one for the target, and one for calibration light. The front end contains a dichroic beam splitter and an atmospheric dispersion corrector, to feed the light into the fibers leading to the spectrographs. Guiding is performed with a separate camera; on-axis as well as off-axis guiding modes are implemented. Fibers with octagonal cross-section are employed to ensure good stability of the output in the presence of residual guiding errors. The

  20. Identification and characterization of hetA, a gene that acts early in the process of morphological differentiation of heterocysts.

    PubMed Central

    Holland, D; Wolk, C P

    1990-01-01

    Envelope polysaccharide is a major early diagnostic of differentiating heterocysts. The mutation in mutant EF116 of Anabaena sp. strain PCC 7120 reduces the cohesiveness of this polysaccharide. A 3.5-kilobase fragment of DNA cloned from the wild type of this Anabaena sp. was previously shown to complement this mutation. We present the nucleotide sequence of a 2,555-base-pair portion of this fragment containing an open reading frame (ORF) of 601 amino acids. Complementation analysis using deletion derivatives of the 3.5-kilobase fragment showed that the gene mutated in EF116, which we designate hetA, lies within this ORF. Transcription of hetA was induced as a result of deprivation for nitrate and yielded a monocistronic mRNA that was present at greatest abundance 7 h after nitrogen stepdown. At that time, proheterocysts could not be distinguished by light microscopy; transcription of nifHD, structural genes of nitrogenase, peaked much later. Situated 3' to hetA are 4 identical repeats of the sequence 5'-TTCAAAA-3' and 12 repeats (10 identical) of the sequence 5'-CCCCAAT-3'. The 12 repeats, present within and near the 5' end of a second ORF, are almost identical to repeats that have been reported to be present in the region between the petC and petA genes of a related cyanobacterium. Images PMID:2111805

  1. Instrument Synthesis and Analysis Laboratory

    NASA Technical Reports Server (NTRS)

    Wood, H. John

    2004-01-01

    The topics addressed in this viewgraph presentation include information on 1) Historic instruments at Goddard; 2) Integrated Design Capability at Goddard; 3) The Instrument Synthesis and Analysis Laboratory (ISAL).

  2. LBL's Pollution Instrumentation Comparability Program.

    ERIC Educational Resources Information Center

    McLaughlin, R. D.; And Others

    1979-01-01

    Contained are condensed excerpts from the Lawrence Berkeley Laboratory Survey of Instrumentation for Environmental Monitoring. The survey describes instrumentation used to analyze air and water quality, radiation emissions, and biomedical impacts. (BB)

  3. Precision Instrument and Equipment Repairers.

    ERIC Educational Resources Information Center

    Wyatt, Ian

    2001-01-01

    Explains the job of precision instrument and equipment repairers, who work on cameras, medical equipment, musical instruments, watches and clocks, and industrial measuring devices. Discusses duties, working conditions, employment and earnings, job outlook, and skills and training. (JOW)

  4. ZBLAN Viscosity Instrumentation

    NASA Technical Reports Server (NTRS)

    Kaukler, William

    2001-01-01

    The past year's contribution from Dr. Kaukler's experimental effort consists of these 5 parts: a) Construction and proof-of-concept testing of a novel shearing plate viscometer designed to produce small shear rates and operate at elevated temperatures; b) Preparing nonlinear polymeric materials to serve as standards of nonlinear Theological behavior; c) Measurements and evaluation of above materials for nonlinear rheometric behavior at room temperature using commercial spinning cone and plate viscometers available in the lab; d) Preparing specimens from various forms of pitch for quantitative comparative testing in a Dynamic Mechanical Analyzer, Thermal Mechanical Analyzer; and Archeological Analyzer; e) Arranging to have sets of pitch specimens tested using the various instruments listed above, from different manufacturers, to form a baseline of the viscosity variation with temperature using the different test modes offered by these instruments by compiling the data collected from the various test results. Our focus in this project is the shear thinning behavior of ZBLAN glass over a wide range of temperature. Experimentally, there are no standard techniques to perform such measurements on glasses, particularly at elevated temperatures. Literature reviews to date have shown that shear thinning in certain glasses appears to occur, but no data is available for ZBLAN glass. The best techniques to find shear thinning behavior require the application of very low rates of shear. In addition, because the onset of the thinning behavior occurs at an unknown elevated temperature, the instruments used in this study must provide controlled low rates of shear and do so for temperatures approaching 600 C. In this regard, a novel shearing parallel plate viscometer was designed and a prototype built and tested.

  5. Instrumental musicians' hazards.

    PubMed

    Hoppmann, R A

    2001-01-01

    In the last two decades, injuries to instrumental musicians have been well documented. Major categories of performance-related injuries include musculoskeletal overuse, nerve entrapment/thoracic outlet syndrome, and focal dystonia. Other areas of concern to instrumentalists include hypermobility, osteoarthritis, fibromyalgia, and hearing loss. This chapter reviews the epidemiology, risk factors, physical exam, treatment, and prevention of common problems of instrumentalists. Emphasis is placed on the team approach of treatment and prevention and the need for close collaboration of the various health professionals, music educators, and performers. Additional resources are presented for those interested in pursuing performing arts medicine in greater detail.

  6. Biomagnetic instrumentation and measurement

    NASA Technical Reports Server (NTRS)

    Iufer, E. J.

    1978-01-01

    The instruments and techniques of biomagnetic measurement have progressed greatly in the past 15 years and are now of a quality appropriate to clinical applications. The paper reports on recent developments in the design and application of SQUID (Superconducting Quantum Interference Device) magnetometers to biomagnetic measurement. The discussion covers biomagnetic field levels, magnetocardiography, magnetic susceptibility plethysmography, ambient noise and sensor types, principles of operation of a SQUID magnetometer, and laboratory techniques. Of the many promising applications of noninvasive biomagnetic measurement, magnetocardiography is the most advanced and the most likely to find clinical application in the near future.

  7. Beam Instrument Development System

    SciTech Connect

    DOOLITTLE, LAWRENCE; HUANG, GANG; DU, QIANG; SERRANO, CARLOS

    2016-01-08

    Beam Instrumentation Development System (BIDS) is a collection of common support libraries and modules developed during a series of Low-Level Radio Frequency (LLRF) control and timing/synchronization projects. BIDS includes a collection of Hardware Description Language (HDL) libraries and software libraries. The BIDS can be used for the development of any FPGA-based system, such as LLRF controllers. HDL code in this library is generic and supports common Digital Signal Processing (DSP) functions, FPGA-specific drivers (high-speed serial link wrappers, clock generation, etc.), ADC/DAC drivers, Ethernet MAC implementation, etc.

  8. Diamonds for beam instrumentation

    SciTech Connect

    Griesmayer, Erich

    2013-04-19

    Diamond is perhaps the most versatile, efficient and radiation tolerant material available for use in beam detectors with a correspondingly wide range of applications in beam instrumentation. Numerous practical applications have demonstrated and exploited the sensitivity of diamond to charged particles, photons and neutrons. In this paper, a brief description of a generic diamond detector is given and the interaction of the CVD diamond detector material with protons, electrons, photons and neutrons is presented. Latest results of the interaction of sCVD diamond with 14 MeV mono-energetic neutrons are shown.

  9. Instrument Quality Control.

    PubMed

    Jayakody, Chatura; Hull-Ryde, Emily A

    2016-01-01

    Well-defined quality control (QC) processes are used to determine whether a certain procedure or action conforms to a widely accepted standard and/or set of guidelines, and are important components of any laboratory quality assurance program (Popa-Burke et al., J Biomol Screen 14: 1017-1030, 2009). In this chapter, we describe QC procedures useful for monitoring the accuracy and precision of laboratory instrumentation, most notably automated liquid dispensers. Two techniques, gravimetric QC and photometric QC, are highlighted in this chapter. When used together, these simple techniques provide a robust process for evaluating liquid handler accuracy and precision, and critically underpin high-quality research programs.

  10. Diaphragms for Aeronautic Instruments

    NASA Technical Reports Server (NTRS)

    Hersey, M D

    1924-01-01

    This investigation was carried out at the request of the National Advisory Committee for Aeronautics and comprises an outline of historical developments and theoretical principles, together with a discussion of expedients for making the most effective use of existing diaphragms actuated by the hydrostatic pressure form an essential element of a great variety instruments for aeronautic and other technical purposes. The various physical data needed as a foundation for rational methods of diaphragm design have not, however, been available hitherto except in the most fragmentary form.

  11. A new innovative instrument for space plasma instrumentation

    NASA Technical Reports Server (NTRS)

    Torbert, Roy B.

    1993-01-01

    The Faraday Ring Ammeter was the subject of this grant for a new innovative instrument for space plasma instrumentation. This report summarizes our progress in this work. Briefly, we have conducted an intensive series of experiments and trials over three years, testing some five configurations of the instrument to measure currents, resulting in two Ph.D. theses, supported by this grant, and two flight configurations of the instrument. The first flight would have been on a NASA-Air Force collaborative sounding rocket, but was not flown because of instrumental difficulties. The second has been successfully integrated on the NASA Auroral Turbulence payload which is to be launched in February, 1994.

  12. Heterozygous Mapping Strategy (HetMappS) for High Resolution Genotyping-By-Sequencing Markers: A Case Study in Grapevine

    PubMed Central

    Wang, Minghui; Londo, Jason P.; Acharya, Charlotte B.; Mitchell, Sharon E.; Sun, Qi; Reisch, Bruce; Cadle-Davidson, Lance

    2015-01-01

    Genotyping by sequencing (GBS) provides opportunities to generate high-resolution genetic maps at a low genotyping cost, but for highly heterozygous species, missing data and heterozygote undercalling complicate the creation of GBS genetic maps. To overcome these issues, we developed a publicly available, modular approach called HetMappS, which functions independently of parental genotypes and corrects for genotyping errors associated with heterozygosity. For linkage group formation, HetMappS includes both a reference-guided synteny pipeline and a reference-independent de novo pipeline. The de novo pipeline can be utilized for under-characterized or high diversity families that lack an appropriate reference. We applied both HetMappS pipelines in five half-sib F1 families involving genetically diverse Vitis spp. Starting with at least 116,466 putative SNPs per family, the HetMappS pipelines identified 10,440 to 17,267 phased pseudo-testcross (Pt) markers and generated high-confidence maps. Pt marker density exceeded crossover resolution in all cases; up to 5,560 non-redundant markers were used to generate parental maps ranging from 1,047 cM to 1,696 cM. The number of markers used was strongly correlated with family size in both de novo and synteny maps (r = 0.92 and 0.91, respectively). Comparisons between allele and tag frequencies suggested that many markers were in tandem repeats and mapped as single loci, while markers in regions of more than two repeats were removed during map curation. Both pipelines generated similar genetic maps, and genetic order was strongly correlated with the reference genome physical order in all cases. Independently created genetic maps from shared parents exhibited nearly identical results. Flower sex was mapped in three families and correctly localized to the known sex locus in all cases. The HetMappS pipeline could have wide application for genetic mapping in highly heterozygous species, and its modularity provides opportunities to

  13. Heterozygous Mapping Strategy (HetMappS) for High Resolution Genotyping-By-Sequencing Markers: A Case Study in Grapevine.

    PubMed

    Hyma, Katie E; Barba, Paola; Wang, Minghui; Londo, Jason P; Acharya, Charlotte B; Mitchell, Sharon E; Sun, Qi; Reisch, Bruce; Cadle-Davidson, Lance

    2015-01-01

    Genotyping by sequencing (GBS) provides opportunities to generate high-resolution genetic maps at a low genotyping cost, but for highly heterozygous species, missing data and heterozygote undercalling complicate the creation of GBS genetic maps. To overcome these issues, we developed a publicly available, modular approach called HetMappS, which functions independently of parental genotypes and corrects for genotyping errors associated with heterozygosity. For linkage group formation, HetMappS includes both a reference-guided synteny pipeline and a reference-independent de novo pipeline. The de novo pipeline can be utilized for under-characterized or high diversity families that lack an appropriate reference. We applied both HetMappS pipelines in five half-sib F1 families involving genetically diverse Vitis spp. Starting with at least 116,466 putative SNPs per family, the HetMappS pipelines identified 10,440 to 17,267 phased pseudo-testcross (Pt) markers and generated high-confidence maps. Pt marker density exceeded crossover resolution in all cases; up to 5,560 non-redundant markers were used to generate parental maps ranging from 1,047 cM to 1,696 cM. The number of markers used was strongly correlated with family size in both de novo and synteny maps (r = 0.92 and 0.91, respectively). Comparisons between allele and tag frequencies suggested that many markers were in tandem repeats and mapped as single loci, while markers in regions of more than two repeats were removed during map curation. Both pipelines generated similar genetic maps, and genetic order was strongly correlated with the reference genome physical order in all cases. Independently created genetic maps from shared parents exhibited nearly identical results. Flower sex was mapped in three families and correctly localized to the known sex locus in all cases. The HetMappS pipeline could have wide application for genetic mapping in highly heterozygous species, and its modularity provides opportunities to

  14. Mallet Instruments Challenge Beginning Percussionists.

    ERIC Educational Resources Information Center

    Grumley, Fred

    1983-01-01

    Orff mallet instruments should be used in beginning band classes. Adding mallet instruments would expand a beginner's concept of percussion instruments. Just as important, the percussion section would provide a solid melodic and harmonic foundation to assist beginning wind instrumentalists with their insecurities about pitch. (RM)

  15. Instruments for Water Quality Measurements

    ERIC Educational Resources Information Center

    Phillips, Sidney L.; Mack, Dick A.

    1975-01-01

    This discussion gives a general picture of the instrumentation available or being developed for measuring the four major categories of water pollutants: metals, nutrients, pesticides and oxygen demand. The instruments are classified as follows: manually operated laboratory analyzers, automated laboratory instrumentation, manual field monitors, and…

  16. Electronic Instruments -- Played or Used?

    ERIC Educational Resources Information Center

    Ulveland, Randall Dana

    1998-01-01

    Compares the experience of playing an acoustic instrument to an electronic instrument by analyzing the constant structures and relationships between the experiences. Concludes that students' understanding of the physical experience of making music increases when experiences with acoustic instruments precede their exposure to electronic…

  17. Spacecraft instrument calibration and stability

    NASA Technical Reports Server (NTRS)

    Gille, J. C.; Feldman, P.; Hudson, R.; Lean, J.; Madden, R.; Mcmaster, L.; Mount, G.; Rottman, G.; Simon, P. C.

    1989-01-01

    The following topics are covered: instrument degradation; the Solar Backscatter Ultraviolet (SBUV) Experiment; the Total Ozone Mapping Spectrometer (TOMS); the Stratospheric Aerosol and Gas Experiment 1 (SAGE-1) and SAGE-2 instruments; the Solar Mesosphere Explorer (SME) UV ozone and near infrared airglow instruments; and the Limb Infrared Monitor of the Stratosphere (LIMS).

  18. Instrument Remote Control via the Astronomical Instrument Markup Language

    NASA Technical Reports Server (NTRS)

    Sall, Ken; Ames, Troy; Warsaw, Craig; Koons, Lisa; Shafer, Richard

    1998-01-01

    The Instrument Remote Control (IRC) project ongoing at NASA's Goddard Space Flight Center's (GSFC) Information Systems Center (ISC) supports NASA's mission by defining an adaptive intranet-based framework that provides robust interactive and distributed control and monitoring of remote instruments. An astronomical IRC architecture that combines the platform-independent processing capabilities of Java with the power of Extensible Markup Language (XML) to express hierarchical data in an equally platform-independent, as well as human readable manner, has been developed. This architecture is implemented using a variety of XML support tools and Application Programming Interfaces (API) written in Java. IRC will enable trusted astronomers from around the world to easily access infrared instruments (e.g., telescopes, cameras, and spectrometers) located in remote, inhospitable environments, such as the South Pole, a high Chilean mountaintop, or an airborne observatory aboard a Boeing 747. Using IRC's frameworks, an astronomer or other scientist can easily define the type of onboard instrument, control the instrument remotely, and return monitoring data all through the intranet. The Astronomical Instrument Markup Language (AIML) is the first implementation of the more general Instrument Markup Language (IML). The key aspects of our approach to instrument description and control applies to many domains, from medical instruments to machine assembly lines. The concepts behind AIML apply equally well to the description and control of instruments in general. IRC enables us to apply our techniques to several instruments, preferably from different observatories.

  19. An Instrumental Innovation

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Think of guitars and you think of rock and country music, or the vigorous rhythms of the gypsy flamenco, or perhaps the classical strumming of a Segovia. About the last thing you would associate with guitars is aerospace technology. Yet there is a connection. A whole family of quality guitars is an outgrowth of helicopter rotor research conducted for the military services and NASA by an aerospace contractor. These musical spinoffs, commercially available and rapidly gaining in popularity, are the Ovation guitar line, manufactured by Ovation Instruments, Inc., Bloomfield, Connecticut. Ovation Instruments is a subsidiary of Kaman Corporation, a diversified company originally formed to develop and build helicopters. A helicopter's rotor system, with thousands of moving parts, is highly susceptible to vibration. For rotor efficiency, vibration must be "dampened," or reduced. Like other helicopter builders, Kaman Corporation spent years of research toward that end. The technology thus developed, together with the availability of staff experts in vibration engineering, sparked an idea in the mind of the company's president and founder, Charles H. Karnan. A guitarist of professional caliber, Kaman reasoned that vibration-dampening technology could be turned around to enhance vibration and thereby produce a guitar with superior sound.

  20. The QUIET Instrument

    NASA Technical Reports Server (NTRS)

    Gaier, T.; Kangaslahti, P.; Lawrence, C. R.; Leitch, E. M.; Wollack, E. J.

    2012-01-01

    The Q/U Imaging ExperimenT (QUIET) is designed to measure polarization in the Cosmic Microwave Background, targeting the imprint of inflationary gravitational waves at large angular scales ( approx 1 deg.) . Between 2008 October and 2010 December, two independent receiver arrays were deployed sequentially on a 1.4 m side-fed Dragonian telescope. The polarimeters which form the focal planes use a highly compact design based on High Electron Mobility Transistors (HEMTs) that provides simultaneous measurements of the Stokes parameters Q, U, and I in a single module. The 17-element Q-band polarimeter array, with a central frequency of 43.1 GHz, has the best sensitivity (69 micro Ks(exp 1/2)) and the lowest instrumental systematic errors ever achieved in this band, contributing to the tensor-to-scalar ratio at r < 0.1. The 84-element W-band polarimeter array has a sensitivity of 87 micro Ks(exp 1/2) at a central frequency of 94.5 GHz. It has the lowest systematic errors to date, contributing at r < 0.01 (QUIET Collaboration 2012) The two arrays together cover multipoles in the range l approximately equals 25-975 . These are the largest HEMT-ba.sed arrays deployed to date. This article describes the design, calibration, performance of, and sources of systematic error for the instrument,

  1. Optomechanical medical devices (instruments)

    NASA Astrophysics Data System (ADS)

    Reiss, Roger S.

    2004-03-01

    Optomechanical Medical Devices (Instruments) use lightwaves (UV, Visible, IR) for one or more of the following functions; to observe, to measure, to record, to test (align) and or to cut/repair. The evolution of Optomechanical Medical Devices probably started when the first torch or candle or petrochemical lamp used a polished reflector (possibly with a concave configuration) to examine a part of a patient's body (possibly a wound).Once the glass lens was invented, light sources of any type could be forcussed to increase illuminating power on a selected area. Medical Devices have come a great distance since these early items. Skipping across time to three rather significant inventions and advancements, we are well into the era of Laser and Fiber Optics and Advanced Photodetectors, all being integrated into Medical Devices. The most notable fields have been Ophthalmology, Dermatology, and Surgery. All three fields have been able to incorporate both the use of the Laser and the use of Fiber Optics (and at times the use of Photodetectors), into a single device (instrument). Historical: Philipp Bozzini (a Doctor, maybe) in the early 1800's used a hollow tube (tube material not identified) to project the light of a candle through the tube to view a patient's 'what ever'. Only Philipp, the patient and G-d knows what was being viewed. This ws the first recorded information on what could be considered the very first 'Endoscope examination'

  2. Space science instrumentation

    NASA Astrophysics Data System (ADS)

    Holzworth, R. H.

    1989-03-01

    This grant was intended to be used for the purchase of high quality laboratory and data analysis instrumentation for the pursuit of space plasma physics research. Two of the first purchases were a 6250 BPI magnetic tape drive and a large, fast disk drive. These improved the satellite data analysis capability greatly and reduced the system backup time. With the big disk drive it became possible to dump entire magnetic tapes to disk for faster, more efficient processing. Several microcomputers improve both personnel computing as well as general connectivity within the group and on campus in general. Other microcomputers function in the laboratory setting by acting as hosts for several instrument interfaces for communication with satellite and balloon payloads as well as laboratory VLF signal processing equipment. Perhaps the single most expensive item purchased was an analog tape drive for reading and writing 16 in. analog magnetic tapes. This analog tape drive is used for the direct processing of FM and directly recorded telemetry data from the balloon and rocket payloads.

  3. Far ultraviolet instrument technology

    NASA Astrophysics Data System (ADS)

    Paxton, Larry J.; Schaefer, Robert K.; Zhang, Yongliang; Kil, Hyosub

    2017-02-01

    The far ultraviolet (FUV) spectral range (from about 115 nm to 180 nm) is one of the most useful spectral regions for characterizing the upper atmosphere (thermosphere and ionosphere). The principal advantages are that there are FUV signatures of the major constituents of the upper atmosphere as well as the signatures of the high-latitude energy inputs. Because of the absorption by thermospheric O2, the FUV signatures are seen against a "black" background, i.e., one that is not affected by ground albedo or clouds and, as a consequence, can make useful observations of the aurora during the day or when the Moon is above the horizon. In this paper we discuss the uses of FUV remote sensing, summarize the various techniques, and discuss the technological challenges. Our focus is on a particular type of FUV instrument, the scanning imaging spectrograph or SIS: an instrument exemplified by the Defense Meteorological Satellite Program Special Sensor Ultraviolet Imager and Thermosphere Ionosphere Mesosphere Energetics and Dynamics Global Ultraviolet Imager. The SIS combines spatial imaging of the disk with limb profiles as well as spectral information at each point in the scan.

  4. The QUIET Instrument

    SciTech Connect

    Bischoff, C.; et al.

    2012-07-01

    The Q/U Imaging ExperimenT (QUIET) is designed to measure polarization in the Cosmic Microwave Background, targeting the imprint of inflationary gravitational waves at large angular scales ({approx}1{sup o}). Between 2008 October and 2010 December, two independent receiver arrays were deployed sequentially on a 1.4m side-fed Dragonian telescope. The polarimeters which form the focal planes use a highly compact design based on High Electron Mobility Transistors (HEMTs) that provides simultaneous measurements of the Stokes parameters Q, U, and I in a single module. The 17-element Q-band polarimeter array, with a central frequency of 43.1 GHz, has the best sensitivity (69 {mu}Ks{sup 1/2}) and the lowest instrumental systematic errors ever achieved in this band, contributing to the tensor-to-scalar ratio at r < 0:1. The 84-element W-band polarimeter array has a sensitivity of 87 {mu}Ks{sup 1/2} at a central frequency of 94.5 GHz. It has the lowest systematic errors to date, contributing at r < 0:01. The two arrays together cover multipoles in the range {ell} {approx} 25 -- 975. These are the largest HEMT-based arrays deployed to date. This article describes the design, calibration, performance of, and sources of systematic error for the instrument.

  5. Instrument Control Unit for the EPD on board Solar Orbiter

    NASA Astrophysics Data System (ADS)

    Sánchez Prieto, S.; Prieto Mateo, M.; Rodríguez Polo; Gutiérrez Molina; Parra Espada, P.; da Silva Fariña, A.

    2013-05-01

    Undoubtedly, Solar Orbiter is the leading mission of the European Space Agency for studying the Sun in the current decade. Its elliptical orbit around the Sun, with a perihelion as low as 0.28 AU and with an increasing inclination of up to more than 25° with respect to the solar equator, makes it ideal for an in-situ environmental study. This study will provide the key to determine how does the Sun create and control the heliosphere, which is the main objective of this mission. One of the ten instruments that are part of the Solar Orbiter's payload is the Energetic Particle Detector (EPD). Its main objective is to measure the composition, timing and distribution functions of suprathermal and energetic particles. Scientific topics to be addressed include the sources, acceleration mechanisms, and transport processes of these particles. EPD is composed of four sensors (STEIN, EPT, HET and SIS), distributed along the spacecraft, and an Instrument Control Unit or ICU. The sensors are able to measure electrons in the energy range from 0.002 to 20 MeV, protons from 0.003 to 100 MeV and nucleons of He to Fe in the range of 0.008 to 200 MeV/n. The ICU is the sole interface with the spacecraft, providing control, communication and data processing to the sensors. Due to the strong reliability requirements associated to the ICU, special care has been taken in the hardware, software and mechanical designs. In this work the development status of the ICU, together with its hardware and software architectures, design decisions and tools are presented.

  6. Instrument specificity in experienced musicians.

    PubMed

    Drost, Ulrich C; Rieger, Martina; Prinz, Wolfgang

    2007-04-01

    Previous studies have shown that experienced pianists have acquired integrated action-effect (A-E) associations. In the present study, we were interested in how specific these associations are for the own instrument by investigating pianists and guitarists. A-E associations were examined by testing whether the perception of a "potential" action-effect has an influence on actions. Participants played chords on their instrument in response to visual stimuli, while they were presented task-irrelevant auditory distractors (congruent or incongruent) in varying instrument timbre. In Experiment 1, pianists exhibited an interference effect with timbres of their own instrument category (keyboard instruments: piano and organ). In Experiment 2 guitarists showed an interference effect only with guitar timbre. Thus, integrated A-E associations primarily seem to consist of a specific component on a sensory-motor level involving the own instrument. Additionally, categorical knowledge about how an instrument is played seems to be involved.

  7. Astronomical Instrumentation System Markup Language

    NASA Astrophysics Data System (ADS)

    Goldbaum, Jesse M.

    2016-05-01

    The Astronomical Instrumentation System Markup Language (AISML) is an Extensible Markup Language (XML) based file format for maintaining and exchanging information about astronomical instrumentation. The factors behind the need for an AISML are first discussed followed by the reasons why XML was chosen as the format. Next it's shown how XML also provides the framework for a more precise definition of an astronomical instrument and how these instruments can be combined to form an Astronomical Instrumentation System (AIS). AISML files for several instruments as well as one for a sample AIS are provided. The files demonstrate how AISML can be utilized for various tasks from web page generation and programming interface to instrument maintenance and quality management. The advantages of widespread adoption of AISML are discussed.

  8. Robotic servicing of EOS instruments

    NASA Technical Reports Server (NTRS)

    Razzaghi, Andrea I.; Juberts, Maris

    1990-01-01

    This paper addresses robotic servicing of the Earth Observing Satellite (EOS) instruments. The goals of implementing a robotic servicing system on EOS would be to maintain the instruments throughout the required mission life and minimize life-cycle costs. To address robot servicing, an initial design concept has been developed which will be applied to a representative EOS instrument. This instrument will be used as a model for determining the most practical level of servicing of its parts, and how to design these parts for robot servicing. Using this representative EOS instrument as a model, a generic design scheme will be developed that can be applied to all EOS instruments. The first task is to determine how to identify which parts must be designed for robot servicing. Next, the requirements imposed on the instruments and the servicing robot when designing for robot serviceability must be examined.

  9. Instrumented Pipeline Initiative

    SciTech Connect

    Thomas Piro; Michael Ream

    2010-07-31

    This report summarizes technical progress achieved during the cooperative agreement between Concurrent Technologies Corporation (CTC) and U.S. Department of Energy to address the need for a for low-cost monitoring and inspection sensor system as identified in the Department of Energy (DOE) National Gas Infrastructure Research & Development (R&D) Delivery Reliability Program Roadmap.. The Instrumented Pipeline Initiative (IPI) achieved the objective by researching technologies for the monitoring of pipeline delivery integrity, through a ubiquitous network of sensors and controllers to detect and diagnose incipient defects, leaks, and failures. This report is organized by tasks as detailed in the Statement of Project Objectives (SOPO). The sections all state the objective and approach before detailing results of work.

  10. NEUTRONIC REACTOR CORE INSTRUMENT

    DOEpatents

    Mims, L.S.

    1961-08-22

    A multi-purpose instrument for measuring neutron flux, coolant flow rate, and coolant temperature in a nuclear reactor is described. The device consists essentially of a hollow thimble containing a heat conducting element protruding from the inner wall, the element containing on its innermost end an amount of fissionsble materinl to function as a heat source when subjected to neutron flux irradiation. Thermocouple type temperature sensing means are placed on the heat conducting element adjacent the fissionable material and at a point spaced therefrom, and at a point on the thimble which is in contact with the coolant fluid. The temperature differentials measured between the thermocouples are determinative of the neutron flux, coolant flow, and temperature being measured. The device may be utilized as a probe or may be incorporated in a reactor core. (AE C)

  11. Sentinel-1 Instrument Overview

    NASA Astrophysics Data System (ADS)

    Snoeij, Paul; Torres, Ramon; Geudtner, Dirk; Brown, Michael; Deghaye, Patrick; Navas-Traver, Ignacio; Ostergaard, Allan; Rommen, Bjorn; Floury, Nicolas; Davidson, Malcolm

    2013-03-01

    The forthcoming European Space Agency (ESA) Sentinel-1 (S-1) C-band SAR constellation will provide continuous all-weather day/night global coverage, with six days exact repetition time (near daily coverage over Europe and Canada) and with radar data delivery within 3 to 24 hours. These features open new possibilities for operational maritime services. The Sentinel-1 space segment has been designed and is being built by an industrial consortium with Thales Alenia Space Italia as prime contractor and EADS Astrium GmbH as C-SAR instrument responsible. It is expected that Sentinel-1A be launched in 2013. This paper will provide an overview of the Sentinel-1 system, the status and characteristics of the technical implementation. The key elements of the system supporting the maritime user community will be highlighted.

  12. Instrumented Architectural Simulation System

    NASA Technical Reports Server (NTRS)

    Delagi, B. A.; Saraiya, N.; Nishimura, S.; Byrd, G.

    1987-01-01

    Simulation of systems at an architectural level can offer an effective way to study critical design choices if (1) the performance of the simulator is adequate to examine designs executing significant code bodies, not just toy problems or small application fragements, (2) the details of the simulation include the critical details of the design, (3) the view of the design presented by the simulator instrumentation leads to useful insights on the problems with the design, and (4) there is enough flexibility in the simulation system so that the asking of unplanned questions is not suppressed by the weight of the mechanics involved in making changes either in the design or its measurement. A simulation system with these goals is described together with the approach to its implementation. Its application to the study of a particular class of multiprocessor hardware system architectures is illustrated.

  13. Portable musical instrument amplifier

    SciTech Connect

    Christian, David E.

    1990-07-24

    The present invention relates to a musical instrument amplifier which is particularly useful for electric guitars. The amplifier has a rigid body for housing both the electronic system for amplifying and processing signals from the guitar and the system's power supply. An input plug connected to and projecting from the body is electrically coupled to the signal amplifying and processing system. When the plug is inserted into an output jack for an electric guitar, the body is rigidly carried by the guitar, and the guitar is operatively connected to the electrical amplifying and signal processing system without use of a loose interconnection cable. The amplifier is provided with an output jack, into which headphones are plugged to receive amplified signals from the guitar. By eliminating the conventional interconnection cable, the amplifier of the present invention can be used by musicians with increased flexibility and greater freedom of movement.

  14. TRU VU rig instrumentation

    SciTech Connect

    Boone, S.G.

    1993-02-15

    TRU VU was developed in response to the growing need for real time rig instrumentation that interface various rig systems into a common database. TRU VU is a WITS compatible (Wellsite Information Transfer Standard) system that logs drilling data and MWD data into a common database. Real time data as well as historical data can be viewed from up to eight locations on the rig or from numerous locations in communication with the rig. The TRU VU well monitoring package can be configured to operate manned or unmanned depending on the specific requirements of the operator or drilling contractor. TRU VU does not require a drilling recorder and is totally independent of all rig systems. For example, depth is monitored directly from the draw works and can monitor pipe movement while drilling or tripping. Weight on bit is zeroed automatically on each connection and does not require manual input.

  15. Incidence of instrument separation using LightSpeed rotary instruments.

    PubMed

    Knowles, Kenneth I; Hammond, Nathan B; Biggs, Stephen G; Ibarrola, Jose L

    2006-01-01

    The use of nickel-titanium rotary instrument systems has gained popularity over the past 10 years. One of these instrument systems is the LightSpeed (LightSpeed Technology, Inc, San Antonio, TX). One drawback for all nickel-titanium rotary instruments is the incidence of instrument separation. The purpose of this study was to evaluate the incidence of nonretrievable instrument separation using the LightSpeed system in a clinical setting. A total of 3543 canals were treated over a 24 month period and during that time, 46 LightSpeed instruments were separated and found to be nonretrievable, resulting in a separation rate of 1.30%. This rate was lower than previous reported studies.

  16. 21 CFR 882.4525 - Microsurgical instrument.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Surgical Devices § 882.4525 Microsurgical instrument. (a) Identification. A microsurgical instrument is a nonpowered surgical instrument used in neurological...

  17. 21 CFR 882.4525 - Microsurgical instrument.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Surgical Devices § 882.4525 Microsurgical instrument. (a) Identification. A microsurgical instrument is a nonpowered surgical instrument used in neurological...

  18. 21 CFR 882.4525 - Microsurgical instrument.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Surgical Devices § 882.4525 Microsurgical instrument. (a) Identification. A microsurgical instrument is a nonpowered surgical instrument used in neurological...

  19. Instrumentation and control systems, equipment location; instrumentation and control building, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Instrumentation and control systems, equipment location; instrumentation and control building, instrumentation room, bays and console plan. Specifications No. Eng-04-353-55-72; drawing no. 60-09-12; sheet 110 of 148; file no. 1321/61. Stamped: Record drawing - as constructed. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Control Center, Test Area 1-115, near Altair & Saturn Boulevards, Boron, Kern County, CA

  20. Woelter Instrument-Optical Design

    SciTech Connect

    Nederbragt, W W

    2002-10-11

    Hundreds of target assemblies will be constructed annually for use on NIF or OMEGA in the near future. Currently, we do not have the capability to tomographically characterize the target assemblies at the desired resolution. Hence, we cannot verify if an assembly has been assembled correctly. The Engineering Directorate, through the LDRD program, is currently funding an x-ray instruments that could solve this problem. This instrument is based on a Woelter [1] Type-I design. We will refer to this design as the Woelter instrument in the remainder of the report. Ideally, the Woelter instrument will create images with sub-micrometer resolution. Moreover, the instrument will have a field-of-view large enough to cover an entire target assembly (up to a 2 mm square), which would eliminate the need to take multiple radiographs to get one complete target image. This report describes the optical design of the Woelter instrument.

  1. Experimenting with string musical instruments

    NASA Astrophysics Data System (ADS)

    LoPresto, Michael C.

    2012-03-01

    What follows are several investigations involving string musical instruments developed for and used in a Science of Sound & Light course. The experiments make use of a guitar, orchestral string instruments and data collection and graphing software. They are designed to provide students with concrete examples of how mathematical formulae, when used in physics, represent reality that can actually be observed, in this case, the operation of string musical instruments.

  2. Radiometric and Spectral Measurement Instruments

    DTIC Science & Technology

    1992-03-18

    NSWCCR/RDTN-92/0003 AD-A250 771LI~ llliii11l li l l iillt111 RADIOMETRIC AND SPECTRAL MEASUREMENT INSTRUMENTS CRANE DIVISION NAVAL SURFACE WARFARE... INSTRUMENTS 6. AUTHOR(S) B. E. DOUDA H. A. WEBSTER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) a. PERFORMING ORGANIZATION REPORT NIJMBER...Maxiry-um 200 w ords) THIS IS A DESCRIPTION OF AN ASSORTMENT OF RADIOMETRIC AND SPECTRAL INSTRUMENTATION USED FOR MEASUREMENT OF THE RADIATIVE OUTPUT OF

  3. Detectors for Tomorrow's Instruments

    NASA Technical Reports Server (NTRS)

    Moseley, Harvey

    2009-01-01

    Cryogenically cooled superconducting detectors have become essential tools for a wide range of measurement applications, ranging from quantum limited heterodyne detection in the millimeter range to direct searches for dark matter with superconducting phonon detectors operating at 20 mK. Superconducting detectors have several fundamental and practical advantages which have resulted in their rapid adoption by experimenters. Their excellent performance arises in part from reductions in noise resulting from their low operating temperatures, but unique superconducting properties provide a wide range of mechanisms for detection. For example, the steep dependence of resistance with temperature on the superconductor/normal transition provides a sensitive thermometer for calorimetric and bolometric applications. Parametric changes in the properties of superconducting resonators provides a mechanism for high sensitivity detection of submillimeter photons. From a practical point of view, the use of superconducting detectors has grown rapidly because many of these devices couple well to SQUID amplifiers, which are easily integrated with the detectors. These SQUID-based amplifiers and multiplexers have matured with the detectors; they are convenient to use, and have excellent noise performance. The first generation of fully integrated large scale superconducting detection systems are now being deployed. I will discuss the prospects for a new generation of instruments designed to take full advantage of the revolution in detector technology.

  4. Instrumentation Working Group Summary

    NASA Technical Reports Server (NTRS)

    Zaller, Michelle; Miake-Lye, Richard

    1999-01-01

    The Instrumentation Working Group compiled a summary of measurement techniques applicable to gas turbine engine aerosol precursors and particulates. An assessment was made of the limits, accuracy, applicability, and technology readiness of the various techniques. Despite advances made in emissions characterization of aircraft engines, uncertainties still exist in the mechanisms by which aerosols and particulates are produced in the near-field engine exhaust. To adequately assess current understanding of the formation of sulfuric acid aerosols in the exhaust plumes of gas turbine engines, measurements are required to determine the degree and importance of sulfur oxidation in the turbine and at the engine exit. Ideally, concentrations of all sulfur species would be acquired, with emphasis on SO2 and SO3. Numerous options exist for extractive and non-extractive measurement of SO2 at the engine exit, most of which are well developed. SO2 measurements should be performed first to place an upper bound on the percentage of SO2 oxidation. If extractive and non-extractive techniques indicate that a large amount of the fuel sulfur is not detected as SO2, then efforts are needed to improve techniques for SO3 measurements. Additional work will be required to account for the fuel sulfur in the engine exhaust. Chemical Ionization Mass Spectrometry (CI-MS) measurements need to be pursued, although a careful assessment needs to be made of the sampling line impact on the extracted sample composition. Efforts should also be placed on implementing non-intrusive techniques and extending their capabilities by maximizing exhaust coverage for line-of-sight measurements, as well as development of 2-D techniques, where feasible. Recommendations were made to continue engine exit and combustor measurements of particulates. Particulate measurements should include particle size distribution, mass fraction, hydration properties, and volatile fraction. However, methods to ensure that unaltered

  5. Optical distance measuring instrument

    NASA Technical Reports Server (NTRS)

    Abshire, J. B. (Inventor)

    1986-01-01

    An optical instrument, such as a stability monitor or a target range finder, uses an unstabilized laser to project a composite optical signal of coherent light having two naturally occurring longitudinal mode components. A beamsplitter divides the signal into a reference beam which is directed toward one photodetector and a transmitted beam which illuminates and is reflected from a distant target onto a second photodetector optically isolated from the first photodetector. Both photodetectors are operated on the square law principle to provide electrical signals modulated at a frequency equal to the separation between the frequencies of the two longitudinal mode components of the optical signal projected by the laser. Slight movement of the target may be detected and measured by electrically monitoring the phase difference between the two signals provided by the photodetectors and the range of the target measured with the aid of a microprocessor by changing the separation between the longitudinal modes by shifting the length of the resonator cavity in an iterative series of increments.

  6. The tissue diagnostic instrument

    NASA Astrophysics Data System (ADS)

    Hansma, Paul; Yu, Hongmei; Schultz, David; Rodriguez, Azucena; Yurtsev, Eugene A.; Orr, Jessica; Tang, Simon; Miller, Jon; Wallace, Joseph; Zok, Frank; Li, Cheng; Souza, Richard; Proctor, Alexander; Brimer, Davis; Nogues-Solan, Xavier; Mellbovsky, Leonardo; Peña, M. Jesus; Diez-Ferrer, Oriol; Mathews, Phillip; Randall, Connor; Kuo, Alfred; Chen, Carol; Peters, Mathilde; Kohn, David; Buckley, Jenni; Li, Xiaojuan; Pruitt, Lisa; Diez-Perez, Adolfo; Alliston, Tamara; Weaver, Valerie; Lotz, Jeffrey

    2009-05-01

    Tissue mechanical properties reflect extracellular matrix composition and organization, and as such, their changes can be a signature of disease. Examples of such diseases include intervertebral disk degeneration, cancer, atherosclerosis, osteoarthritis, osteoporosis, and tooth decay. Here we introduce the tissue diagnostic instrument (TDI), a device designed to probe the mechanical properties of normal and diseased soft and hard tissues not only in the laboratory but also in patients. The TDI can distinguish between the nucleus and the annulus of spinal disks, between young and degenerated cartilage, and between normal and cancerous mammary glands. It can quantify the elastic modulus and hardness of the wet dentin left in a cavity after excavation. It can perform an indentation test of bone tissue, quantifying the indentation depth increase and other mechanical parameters. With local anesthesia and disposable, sterile, probe assemblies, there has been neither pain nor complications in tests on patients. We anticipate that this unique device will facilitate research on many tissue systems in living organisms, including plants, leading to new insights into disease mechanisms and methods for their early detection.

  7. Ultrasonics and space instrumentation

    NASA Technical Reports Server (NTRS)

    1987-01-01

    The design topic selected was an outgrowth of the experimental design work done in the Fluid Behavior in Space experiment, which relies on the measurement of minute changes of the pressure and temperature to obtain reasonably accurate volume determinations. An alternative method of volume determination is the use of ultrasonic imaging. An ultrasonic wave system is generated by wall mounted transducer arrays. The interior liquid configuration causes reflection and refraction of the pattern so that analysis of the received wave system provides a description of the configuration and hence volume. Both continuous and chirp probe beams were used in a laboratory experiment simulating a surface wetting propellant. The hardware included a simulated tank with gaseous voids, transmitting and receiving transducers, transmitters, receivers, computer interface, and computer. Analysis software was developed for image generation and interpretation of results. Space instrumentation was pursued in support of a number of experiments under development for GAS flights. The program included thirty undergraduate students pursuing major qualifying project work under the guidance of eight faculty supported by a teaching assistant. Both mechanical and electrical engineering students designed and built several microprocessor systems to measure parameters such as temperature, acceleration, pressure, velocity, and circulation in order to determine combustion products, vortex formation, gas entrainment, EMR emissions from thunderstorms, and milli-g-accelerations due to crew motions.

  8. Halo vest instrumentation

    NASA Astrophysics Data System (ADS)

    Huston, Dryver R.; Krag, Martin

    1996-05-01

    The halo vest is a head and neck immobilization system that is often used on patients that are recovering from cervical trauma or surgery. The halo vest system consists of a rigid halo that is firmly attached to the skull, an upright support structure for stabilization and immobilization, and a torso-enveloping vest. The main purpose of this study was to measure the forces that are carried by the halo-vest structure as the subject undergoes various activities of daily living and external loading for different vest designs. A tethered strain gage load cell based instrumentation system was used to take these load measurements on ten different subjects. Three different halo-vest systems were evaluated. The primary difference between the vests was the amount of torso coverage and the use of shoulder straps. The loads were measured, analyzed and used to compare the vests and to create a model of halo-vest-neck mechanics. Future applications of this technology to standalone data logging, pin-load measuring and biofeedback applications are discussed.

  9. Guideline implementation: surgical instrument cleaning.

    PubMed

    Cowperthwaite, Liz; Holm, Rebecca L

    2015-05-01

    Cleaning, decontaminating, and handling instructions for instruments vary widely based on the type of instrument and the manufacturer. Processing instruments in accordance with the manufacturer's instructions can help prevent damage and keep devices in good working order. Most importantly, proper cleaning and disinfection may prevent transmission of pathogenic organisms from a contaminated device to a patient or health care worker. The updated AORN "Guideline for cleaning and care of surgical instruments" provides guidance on cleaning, decontaminating, transporting, inspecting, and storing instruments. This article focuses on key points of the guideline to help perioperative personnel implement appropriate instrument care protocols in their practice settings. The key points address timely cleaning and decontamination of instruments after use; appropriate heating, ventilation, and air conditioning parameters for the decontamination area; processing of ophthalmic instruments and laryngoscopes; and precautions to take with instruments used in cases of suspected prion disease. Perioperative RNs should review the complete guideline for additional information and for guidance when writing and updating policies and procedures.

  10. Spacecraft instrument technology and cosmochemistry.

    PubMed

    McSween, Harry Y; McNutt, Ralph L; Prettyman, Thomas H

    2011-11-29

    Measurements by instruments on spacecraft have significantly advanced cosmochemistry. Spacecraft missions impose serious limitations on instrument volume, mass, and power, so adaptation of laboratory instruments drives technology. We describe three examples of flight instruments that collected cosmochemical data. Element analyses by Alpha Particle X-ray Spectrometers on the Mars Exploration Rovers have revealed the nature of volcanic rocks and sedimentary deposits on Mars. The Gamma Ray Spectrometer on the Lunar Prospector orbiter provided a global database of element abundances that resulted in a new understanding of the Moon's crust. The Ion and Neutral Mass Spectrometer on Cassini has analyzed the chemical compositions of the atmosphere of Titan and active plumes on Enceladus.

  11. ProtoEXIST2: Advanced Wide-field Imaging CZT Detector Development For The HET On The Proposed EXIST Mission

    NASA Astrophysics Data System (ADS)

    Hong, JaeSub; Allen, B.; Grindlay, J.; Barthelmy, S.; Baker, R.; Gehrels, N.; Cook, W.; Kaye, S.; Harrison, F.

    2010-03-01

    We describe our development of ProtoEXIST2, the advanced CZT imaging detector and wide field telescope prototype for the High Energy Telescope (HET) on the proposed Energetic X-ray Imaging Survey Telescope (EXIST) mission. EXIST is a multi-wavelength Medium class mission which would explore the early Universe using high redshift Gamma-ray Bursts and survey black holes on all scales. ProtoEXIST2 will demonstrate the feasibility of a large scale imaging module (256 cm2) with a close-tiled array of fine pixel (0.6 mm) CZT with a balloon flight test in 2010 or 2011. This second generation close-tiled CZT imager follows ProtoEXIST1, which had a recent successful balloon flight (see Allen et al in this meeting) using the same area CZT detector module (256 cm2) but with larger pixel size (2.5mm). For signal readout and event processing, we use the Direct-Bond (DB) ASIC, developed for the NuSTAR mission to be used in a close-tiled 2 x 2 array of 2x2 cm2 CZT detectors, each with 32x32 pixels. The DB-ASIC is attractive for a large scale implementation of tiled imaging CZT detectors given its low noise and power consumption (70uW/pixel). We are developing readout for the DB-ASIC that incorporates our back-end FPGA readout architecture developed for ProtoEXIST1 in order to accomplish the 256 cm2 detector module area with totally vertical integration (i.e. no auxialliary boards to the sides of the module. This is required to tile large numbers of modules into the very large total area (4.5m^2) proposed for the HET on EXIST. We review the design of the EXIST/HET and its optimum shielding in light of our ProtoEXIST1 balloon flight and our plan for future development of ProtoEXIST3, a final EXIST/HET detector module that would incorporate a still lower power version of the DB ASIC.

  12. MISR Instrument Data Visualization

    NASA Technical Reports Server (NTRS)

    Nelson, David; Garay, Michael; Diner, David; Thompson, Charles; Hall, Jeffrey; Rheingans, Brian; Mazzoni, Dominic

    2008-01-01

    The MISR Interactive eXplorer (MINX) software functions both as a general-purpose tool to visualize Multiangle Imaging SpectroRadiometer (MISR) instrument data, and as a specialized tool to analyze properties of smoke, dust, and volcanic plumes. It includes high-level options to create map views of MISR orbit locations; scrollable, single-camera RGB (red-greenblue) images of MISR level 1B2 (L1B2) radiance data; and animations of the nine MISR camera images that provide a 3D perspective of the scenes that MISR has acquired. NASA Tech Briefs, September 2008 55 The plume height capability provides an accurate estimate of the injection height of plumes that is needed by air quality and climate modelers. MISR provides global high-quality stereo height information, and this program uses that information to perform detailed height retrievals of aerosol plumes. Users can interactively digitize smoke, dust, or volcanic plumes and automatically retrieve heights and winds, and can also archive MISR albedos and aerosol properties, as well as fire power and brightness temperatures associated with smoke plumes derived from Moderate Resolution Imaging Spectroradiometer (MODIS) data. Some of the specialized options in MINX enable the user to do other tasks. Users can display plots of top-of-atmosphere bidirectional reflectance factors (BRFs) versus camera-angle for selected pixels. Images and animations can be saved to disk in various formats. Also, users can apply a geometric registration correction to warp camera images when the standard processing correction is inadequate. It is possible to difference the images of two MISR orbits that share a path (identical ground track), as well as to construct pseudo-color images by assigning different combinations of MISR channels (angle or spectral band) to the RGB display channels. This software is an interactive application written in IDL and compiled into an IDL Virtual Machine (VM) ".sav" file.

  13. Ratio imaging instrumentation.

    PubMed

    Dunn, Kenneth; Maxfield, Frederick R

    2003-01-01

    Using ratio imaging to obtain quantitative information from microscope images is a powerful tool that has been used successfully in numerous studies. Although ratio imaging reduces the effects of many parameters that can interfere with accurate measurements, it is not a panacea. In designing a ratio imaging experiment, all of the potential problems discussed in this chapter must be considered. Undoubtedly, other problems that were not discussed can also interfere with accurate and meaningful measurements. Many of the problems discussed here were observed in the authors' laboratories. In our experience there are no standard routines or methods that can foresee every problem before it has been encountered. Good experimental design can minimize problems, but the investigator must continue to be alert. Progress in instrumentation continues to overcome some of the difficulties encountered in ratio imaging. CCD cameras with 12- to 14-bit pixel depth are being used more frequently, and several confocal microscope manufacturers are now also using 12-bit digitization. The dramatic increase in the use of confocal microscopes over the past decade is now causing microscope manufacturers to more critically evaluate the effect of axial chromatic aberration in objectives, and recent designs to minimize this problem are being implemented. Other developments such as the use of AOTFs to attenuate laser lines extend the applicability of ratio imaging. Ratio imaging is clearly applicable to a wide range of cell biological problems beyond its widespread use for measuring ion concentrations. Imaginative but careful use of this technique should continue to provide novel insights into the properties of cells.

  14. Kodaly Strategies for Instrumental Teachers.

    ERIC Educational Resources Information Center

    Howard, Priscella M.

    1996-01-01

    Advocates using the singing voice and the study of folk music in instrumental instruction. Recommends instrumental teachers confer with voice teachers to coordinate ideas and terminology. Includes several excerpts of scores and musical exercises, as well as a list of selected resources. (MJP)

  15. Science Process Instrument. Experimental Edition.

    ERIC Educational Resources Information Center

    American Association for the Advancement of Science, Washington, DC. Commission on Science Education.

    This instrument contains activities by which one can determine a child's intellectual development in: (1) observing, (2) classifying, (3) measuring, (4) using numbers, (5) using space/time relationships, (6) inferring, and (7) communicating and predicting. The seven sections of the instrument correspond to those processes defined in Science - A…

  16. Technician Program Uses Advanced Instruments.

    ERIC Educational Resources Information Center

    Stinson, Stephen

    1981-01-01

    Describes various aspects of a newly-developed computer-assisted drafting/computer-assisted manufacture (CAD/CAM) facility in the chemical engineering technology department at Broome Community College, Binghamton, New York. Stresses the use of new instruments such as microcomputers and microprocessor-equipped instruments. (CS)

  17. Rating Scale Instruments and Measurement

    ERIC Educational Resources Information Center

    Cavanagh, Robert F.; Romanoski, Joseph T.

    2006-01-01

    The article examines theoretical issues associated with measurement in the human sciences and ensuring data from rating scale instruments are measures. An argument is made that using raw scores from rating scale instruments for subsequent arithmetic operations and applying linear statistics is less preferable than using measures. These theoretical…

  18. Zach's instruments and their characteristics

    NASA Astrophysics Data System (ADS)

    Wolfschmidt, Gudrun

    The astronomically interested Duke Ernst II von Sachsen-Gotha-Altenburg (1745-1804) hired Baron Franz Xaver von Zach (1754-1832) as court astronomer in 1786. Immediatedly Zach started to make plans for instrumentation for a new observatory. But first they travelled with their instruments (a 2-foot Ramsden transit instrument, the Sisson quadrant, three Hadley sextants, two achromatic refractors and chronometers) to southern France. In Hyàres a tower of the wall around the town was converted into an observatory in 1787. For the building of the new observatory Zach had chosen a place outside of Gotha on the top of the Seeberg. The three main instruments were an 8-foot transit instrument made by Ramsden, a northern and southern mural quadrant made by Sisson and a zenith sector made by Cary, in addition an 8-foot circle made by Ramsden. By analysing the whole instrumentation of Gotha observatory, we can see a change around 1800 in the kind of instruments, from quadrants and sextants to the full circles and from the transit instrument to the meridian circle. The decline of the Gotha observatory started with the early death of the Duke in 1804 and the subsequent departure of Zach in 1806.

  19. Experimenting with String Musical Instruments

    ERIC Educational Resources Information Center

    LoPresto, Michael C.

    2012-01-01

    What follows are several investigations involving string musical instruments developed for and used in a "Science of Sound & Light" course. The experiments make use of a guitar, orchestral string instruments and data collection and graphing software. They are designed to provide students with concrete examples of how mathematical formulae, when…

  20. Associations in Human Instrumental Conditioning

    ERIC Educational Resources Information Center

    Gamez, A. Matias; Rosas, Juan M.

    2007-01-01

    Four experiments were conducted to study the contents of human instrumental conditioning. Experiment 1 found positive transfer between a discriminative stimulus (S[superscript D] and an instrumental response (R) that shared the outcome (O) with the response that was originally trained with the S[superscript D], showing the formation of an…

  1. Introduction to Instrumentation. Teacher Edition.

    ERIC Educational Resources Information Center

    Brown, A. O., III

    This module contains instructional materials on instrumentation to help teachers train students in the job skills they will need as beginning instrumentation technicians. The module addresses the nature of accessing, measuring, and controlling phenomena such as level, flow, pressure, and temperature. Students are introduced to the devices and…

  2. Instrument Remote Control Application Framework

    NASA Technical Reports Server (NTRS)

    Ames, Troy; Hostetter, Carl F.

    2006-01-01

    The Instrument Remote Control (IRC) architecture is a flexible, platform-independent application framework that is well suited for the control and monitoring of remote devices and sensors. IRC enables significant savings in development costs by utilizing extensible Markup Language (XML) descriptions to configure the framework for a specific application. The Instrument Markup Language (IML) is used to describe the commands used by an instrument, the data streams produced, the rules for formatting commands and parsing the data, and the method of communication. Often no custom code is needed to communicate with a new instrument or device. An IRC instance can advertise and publish a description about a device or subscribe to another device's description on a network. This simple capability of dynamically publishing and subscribing to interfaces enables a very flexible, self-adapting architecture for monitoring and control of complex instruments in diverse environments.

  3. [Celebration speech marking the 150th anniversary of the Vereniging Nederlands Tijdschrift voor Geneeskunde (Association Dutch Journal of Medicine)].

    PubMed

    Kennedy, J C

    2007-02-17

    The Nederlands Tijdschrift voor Geneeskunde (NTvG [Dutch Journal of Medicine]) celebrates its 150th anniversary this year. J. van der Meer and S.van 't Hofare the editors of a jubilee book issued to mark the occasion. Two earlier books, issued for the 50th and 100th anniversary of the journal, focused primarily on the history of the association of editors which publishes the NTvG. Unlike these books, a large portion of the current jubilee book is devoted to the history of medicine in the Netherlands in the last 50 years. Of greater importance is that the authors reflect on the relationship between the NTvG, the medical profession and society at large. This relationship has intensified since the 1960's. The NTvG has accomplished its goal of being a general medical journal, but lacks 'the voice of the patient' and editorial comments on current social issues. With respect to the physician-patient relationship, the Netherlands has succeeded more than other countries in diminishing the gap between these two partners. The way the Dutch have dealt with the issue of euthanasia is a clear example. But as to the role of the physician in society, the loss of position and authority, increasing professionalism and specialisation and reluctance to engage in social and ethical debate for fear of losing impartiality have caused the medical profession to assume a marginal position in society, even with respect to its own needs as a group of professionals. At present, there is a clear need for physician citizenship that engages in a broad spectrum of social responsibilities in a professional context.

  4. Instrumental variables and Mendelian randomization with invalid instruments

    NASA Astrophysics Data System (ADS)

    Kang, Hyunseung

    Instrumental variables (IV) methods have been widely used to determine the causal effect of a treatment, exposure, policy, or an intervention on an outcome of interest. The IV method relies on having a valid instrument, a variable that is (A1) associated with the exposure, (A2) has no direct effect on the outcome, and (A3) is unrelated to the unmeasured confounders associated with the exposure and the outcome. However, in practice, finding a valid instrument, especially those that satisfy (A2) and (A3), can be challenging. For example, in Mendelian randomization studies where genetic markers are used as instruments, complete knowledge about instruments' validity is equivalent to complete knowledge about the involved genes' functions. The dissertation explores the theory, methods, and application of IV methods when invalid instruments are present. First, when we have multiple candidate instruments, we establish a theoretical bound whereby causal effects are only identified as long as less than 50% of instruments are invalid, without knowing which of the instruments are invalid. We also propose a fast penalized method, called sisVIVE, to estimate the causal effect. We find that sisVIVE outperforms traditional IV methods when invalid instruments are present both in simulation studies as well as in real data analysis. Second, we propose a robust confidence interval under the multiple invalid IV setting. This work is an extension of our work on sisVIVE. However, unlike sisVIVE which is robust to violations of (A2) and (A3), our confidence interval procedure provides honest coverage even if all three assumptions, (A1)-(A3), are violated. Third, we study the single IV setting where the one IV we have may actually be invalid. We propose a nonparametric IV estimation method based on full matching, a technique popular in causal inference for observational data, that leverages observed covariates to make the instrument more valid. We propose an estimator along with

  5. Instrument Concept for the Proposed DESDynI SAR instrument

    NASA Technical Reports Server (NTRS)

    Perkovic-Martin, Dragana; Hoffman, James P.; Veilleux, Louise

    2012-01-01

    The proposed DESDynI (Solid Earth Deformation, Ecosystems Structure and Dynamics of Ice) SAR (synthetic aperture radar) Instrument would expand the trade-space of radar instrument concepts and push the boundaries of high-level integration of digital and RF subsystems in order to achieve very precise assessments of system's behavior; DESDynI mission concept would provide continuous science measurements that would greatly enhance understanding of geophysical and anthropological effects in three science disciplines; Trades in instrument architecture implementations and partnership discussions are producing a set of options for science community and NASA to evaluate and consider implementing late in the decade.

  6. Investigating the Mutagenicity of a Cold Argon-Plasma Jet in an HET-MN Model

    PubMed Central

    Bender, Claudia; Benkhai, Hicham; Sckell, Axel; Below, Harald; Stope, Matthias B.; Kramer, Axel

    2016-01-01

    Objective So-called cold physical plasmas for biomedical applications generate reactive oxygen and nitrogen species and the latter can trigger DNA damage at high concentrations. Therefore, the mutagenic risks of a certified atmospheric pressure argon plasma jet (kINPen MED) and its predecessor model (kINPen 09) were assessed. Methods Inner egg membranes of fertilized chicken eggs received a single treatment with either the kINPen 09 (1.5, 2.0, or 2.5 min) or the kINPen MED (3, 4, 5, or 10 min). After three days of incubation, blood smears (panoptic May-Grünwald-Giemsa stain) were performed, and 1000 erythrocytes per egg were evaluated for the presence of polychromatic and normochromic nuclear staining as well as nuclear aberrations and binucleated cells (hen’s egg test for micronuclei induction, HET-MN). At the same time, the embryo mortality was documented. For each experiment, positive controls (cyclophosphamide and methotrexate) and negative controls (NaCl-solution, argon gas) were included. Additionally, the antioxidant potential of the blood plasma was assessed by ascorbic acid oxidation assay after treatment. Results For both plasma sources, there was no evidence of genotoxicity, although at the longest plasma exposure time of 10 min the mortality of the embryos exceeded 40%. The antioxidant potential in the egg’s blood plasma was not significantly reduced immediately (p = 0.32) or 1 h (p = 0.19) post exposure to cold plasma. Conclusion The longest plasma treatment time with the kINPen MED was 5–10 fold above the recommended limit for treatment of chronic wounds in clinics. We did not find mutagenic effects for any plasma treatment time using the either kINPen 09 or kINPen MED. The data provided with the current study seem to confirm the lack of a genotoxic potential suggesting that a veterinary or clinical application of these argon plasma jets does not pose mutagenic risks. PMID:27584003

  7. Inrichting Gemeenschappelijke Ops-Room Voor DTO, JCG en C2000 (A Common Operations Room for DTO, JCG and C2000)

    DTIC Science & Technology

    2007-02-01

    een 3D digitale eisen en wensen leiden tot nieuwe Beschrijving van de mockup en een 2D plattegrond van de uitgangspunten en tot herontwerp...initiele ontwerp is gemodelleerd in een 3D digitale mockup en 2D plattegrond van de ruimte. De unifornie werkplek, met gescheiden toegang tot secure en...geplaatst kunnen worden. Digitale 24-uurs klokken, minstens 5 of 6 tijdzones tegeijik. Er is 66n crisisruimate opgenomen in het ontwerp. Onduidelijk is

  8. Solid motor diagnostic instrumentation. [design of self-contained instrumentation

    NASA Technical Reports Server (NTRS)

    Nakamura, Y.; Arens, W. E.; Wuest, W. S.

    1973-01-01

    A review of typical surveillance and monitoring practices followed during the flight phases of representative solid-propellant upper stages and apogee motors was conducted to evaluate the need for improved flight diagnostic instrumentation on future spacecraft. The capabilities of the flight instrumentation package were limited to the detection of whether or not the solid motor was the cause of failure and to the identification of probable primary failure modes. Conceptual designs of self-contained flight instrumentation packages capable of meeting these reqirements were generated and their performance, typical cost, and unit characteristics determined. Comparisons of a continuous real time and a thresholded hybrid design were made on the basis of performance, mass, power, cost, and expected life. The results of this analysis substantiated the feasibility of a self-contained independent flight instrumentation module as well as the existence of performance margins by which to exploit growth option applications.

  9. GEO Sounding Using Microwave Instruments

    NASA Technical Reports Server (NTRS)

    Shiue, James; Krimchansky, Sergey; Susskind, Joel; Krimchansky, Alexander; Chu, Donald; Davis, Martin

    2004-01-01

    There are several microwave instruments in low Earth orbit (LEO) that are used for atmospheric temperature and humidity sounding in conjunction with companion IR sounders as well as by themselves. These instruments have achieved a certain degree of maturity and undergoing a redesign to minimize their size, mass, and power from the previous generation instruments. An example of these instruments is the AMSU-A series, now flying on POES and AQUA spacecraft with the IR sounders HIRS and AIRS. These older microwave instruments are going to be replaced by the ATMS instruments that will fly on NPP and NPOESS satellites with the CrIS sounder. A number of techniques learned from the ATMS project in instrument hardware design and data processing are directly applicable to a similar microwave sounder on a geosynchronous platform. These techniques can significantly simplify the design of a Geostationary orbit (GEO) microwave instrument, avoiding costly development and minimizing the risk of not being able to meet the scientific requirements. In fact, some of the 'enabling' technology, such as the use of MMIC microwave components (which is the basis for the ATMS' much reduced volume) can be directly applied to a GEO sounder. The benefits of microwave sounders are well known; for example, they penetrate non-precipitating cloud cover and allow for use of colocated IR observations in up to 80% cloud cover. The key advantages of a microwave instrument in GEO will be the ability to provide high temporal resolution as well as uniform spatial resolution and extend the utility of a colocated advanced IR sounder to cases in which partial cloud cover exists. A footprint of the order of 100 km by 100 km resolution with hemispherical coverage within one hour can be easily achieved for sounding channels in the 50 to 59 GHz range. A GEO microwave sounder will also allow mesoscale sampling of select regions.

  10. The JCMT future instrumentation project

    NASA Astrophysics Data System (ADS)

    Dempsey, Jessica T.; Ho, Paul T. P.; Walther, Craig; Friberg, Per; Bintley, Dan; Chen, Ming-Tang

    2016-08-01

    Under the new operational purview of the East Asian Observatory, the JCMT continues to produce premier wide-field submillimetre science. Now the Observatory looks to embark on an ambitious series of instrumentation upgrades and opportunities to keep the telescope at the bleeding edge of its performance capabilities, whilst harnessing the collaborative expertise of the participating EAO regions and its JCMT partners. New heterodyne instruments include a new receiver at 230 GHz, a super array (90 pixels) at 345 GHz and the upgrade possibilities for the continuum camera SCUBA-2. In addition, the opportunities for PI and visiting instruments, including TimePilot and Gismo-2 will be described.

  11. Commissioning Instrument for the GTC

    NASA Astrophysics Data System (ADS)

    Cuevas, S.; Sánchez, B.; Bringas, V.; Espejo, C.; Flores, R.; Chapa, O.; Lara, G.; Chavolla, A.; Anguiano, G.; Arciniega, S.; Dorantes, A.; González, J. L.; Montoya, J. M.; Toral, R.; Hernández, H.; Nava, R.; Devaney, N.; Castro, J.; Cavaller-Marqués, L.

    2005-12-01

    During the GTC integration phase, the Commissioning Instrument (CI) will be a diagnostic tool for performance verification. The CI features four operation modes: imaging, pupil imaging, Curvature WFS, and high resolution Shack-Hartmann WFS. This instrument was built by the Instituto de Astronomía UNAM and the Centro de Ingeniería y Desarrollo Industrial (CIDESI) under GRANTECAN contract after a public bid. In this paper we made a general instrument overview and we show some of the performance final results obtained when the Factory Acceptance tests previous to its transport to La Palma.

  12. Burried broken extraction instrument fragment

    PubMed Central

    Balaji, S. M.

    2013-01-01

    Despite adequate effort to perform tooth removal carefully, some accidents may happen when defective instruments are unknowingly used. This article reports of a non-symptomatic case of a retained fractured dental elevator tip during an uneventful extraction a decade earlier. Patient was not aware till routine radiographic examination revealed its presence. Use of three dimensional imaging techniques in this case is highlighted. Rarely, instruments breakage may occur during surgical procedures. It is duty of the dentists to check the surgical instrument for signs of breakage and be prepared to solve a possible emergency. Retained fragments should be carefully studied prior to attempt of removal. PMID:23662269

  13. Foundations of measurement and instrumentation

    NASA Technical Reports Server (NTRS)

    Warshawsky, Isidore

    1990-01-01

    The user of instrumentation has provided an understanding of the factors that influence instrument performance, selection, and application, and of the methods of interpreting and presenting the results of measurements. Such understanding is prerequisite to the successful attainment of the best compromise among reliability, accuracy, speed, cost, and importance of the measurement operation in achieving the ultimate goal of a project. Some subjects covered are dimensions; units; sources of measurement error; methods of describing and estimating accuracy; deduction and presentation of results through empirical equations, including the method of least squares; experimental and analytical methods of determining the static and dynamic behavior of instrumentation systems, including the use of analogs.

  14. Adjustable extender for instrument module

    DOEpatents

    Sevec, J.B.; Stein, A.D.

    1975-11-01

    A blank extender module used to mount an instrument module in front of its console for repair or test purposes has been equipped with a rotatable mount and means for locking the mount at various angles of rotation for easy accessibility. The rotatable mount includes a horizontal conduit supported by bearings within the blank module. The conduit is spring-biased in a retracted position within the blank module and in this position a small gear mounted on the conduit periphery is locked by a fixed pawl. The conduit and instrument mount can be pulled into an extended position with the gear clearing the pawl to permit rotation and adjustment of the instrument.

  15. Genetic markers as instrumental variables

    PubMed Central

    von Hinke, Stephanie; Davey Smith, George; Lawlor, Debbie A.; Propper, Carol; Windmeijer, Frank

    2016-01-01

    The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists, statisticians, epidemiologists and social scientists. Although IV is commonly used in economics, the appropriate conditions for the use of genetic variants as instruments have not been well defined. The increasing availability of biomedical data, however, makes understanding of these conditions crucial to the successful use of genotypes as instruments. We combine the econometric IV literature with that from genetic epidemiology, and discuss the biological conditions and IV assumptions within the statistical potential outcomes framework. We review this in the context of two illustrative applications. PMID:26614692

  16. Tailoring Instrumentation to the Operator.

    ERIC Educational Resources Information Center

    Abplanalp, Glen H.; Menzenhauer, Fred C.

    1978-01-01

    This article provides guidelines in selecting appropriate instrumentation for water treatment facilities. Major areas of concern include: technical operating requirements of the process; equipment design and quality; installations; and mechanical aptitude of personnel. (CS)

  17. Islamic Astronomical Instruments and Observatories

    NASA Astrophysics Data System (ADS)

    Heidarzadeh, Tofigh

    This chapter is a brief survey of astronomical instruments being used and developed in Islamic territories from the eighth to the fifteenth centuries as well as a concise account of major observatories and observational programs in this period.

  18. Spacecraft instrument technology and cosmochemistry

    PubMed Central

    McSween, Harry Y.; McNutt, Ralph L.; Prettyman, Thomas H.

    2011-01-01

    Measurements by instruments on spacecraft have significantly advanced cosmochemistry. Spacecraft missions impose serious limitations on instrument volume, mass, and power, so adaptation of laboratory instruments drives technology. We describe three examples of flight instruments that collected cosmochemical data. Element analyses by Alpha Particle X-ray Spectrometers on the Mars Exploration Rovers have revealed the nature of volcanic rocks and sedimentary deposits on Mars. The Gamma Ray Spectrometer on the Lunar Prospector orbiter provided a global database of element abundances that resulted in a new understanding of the Moon’s crust. The Ion and Neutral Mass Spectrometer on Cassini has analyzed the chemical compositions of the atmosphere of Titan and active plumes on Enceladus. PMID:21402932

  19. Venus Heat Flow Instrument Development

    NASA Astrophysics Data System (ADS)

    Pauken, M.; Smith, K.; Sujittosakul, S.; Li, B.; Firdosy, S.; Smrekar, S.; Morgan, P.

    2016-10-01

    A heat flux measurement instrument is being developed to determine the heat flow through the Venus surface. Heat flow measurement provides data for distinguishing between various hypotheses of planetary evolution.

  20. Course on Instruments Updates Teachers.

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1986

    1986-01-01

    Describes a course in chemical instrumentation for high school chemistry teachers, paid for by Union Carbide. Teachers used spectrophotometer, nuclear magnetic resonance spectrometer, atomic absorption spectrograph, gas chromatograph, liquid chromatograph and infrared spectrophotometer. Also describes other teacher education seminars. (JM)

  1. Ames Scientists Develop MSL Instrument

    NASA Video Gallery

    David Blake, a research scientist at NASA Ames, led the development of CheMin, one of ten scientific instruments onboard Curiosity, the Mars Scientific Laboratory. The Powder X-Ray Diffraction tool...

  2. Life support subsystem monitoring instrumentation

    NASA Technical Reports Server (NTRS)

    Powell, J. D.; Kostell, G. D.

    1974-01-01

    The recognition of the need for instrumentation in manned spacecraft life-support subsystems has increased significantly over the past several years. Of the required control and monitoring instrumentation, this paper will focus on the monitoring instrumentation as applied to life-support subsystems. The initial approach used independent sensors, independent sensor signal conditioning circuitry, and independent logic circuitry to provide shutdown protection only. This monitoring system was replaced with a coordinated series of printed circuit cards, each of which contains all the electronics to service one sensor and provide performance trend information, fault detection and isolation information, and shutdown protection. Finally, a review of sensor and instrumentation problems is presented, and the requirement for sensors with built-in signal conditioning and provisions for in situ calibration is discussed.

  3. Portable instruments for emergency response

    NASA Astrophysics Data System (ADS)

    Swinth, K. L.

    1985-05-01

    The selection and use of instruments for emergency response is complicated by lack of specific guidance, the diversity of potential conditions, and the variable performance of available instruments. The user must examine the projected radiological conditions during an accident and the environmental extremes that could exist. This should assist in determining requirements that the instruments must meet during an emergency. Due to the variable performance of available instrumentation, critical parameters (temperature dependence) should be tested prior to use to assure adequate measurements. Although it is tempting to stock emergency kits with inexpensive monitoring equipment, one should carefully consider the possible conditions (environmental, radiological) and equipment performance since inaccurate measurements could be very costly in terms of decisions regarding lifesaving and evacuation during an emergency.

  4. Instrument detects bacterial life forms

    NASA Technical Reports Server (NTRS)

    Plakas, C.

    1971-01-01

    Instrument assays enzymatic bioluminescent reaction that occurs when adenosine triphosphate /ATP/ combines with lucifrase and luciferin. Module assembly minimizes need for hardware associated with reaction fluid and waste transfer. System is applicable in marine biology and aerospace and medical fields.

  5. Instrumentation for Air Pollution Monitoring

    ERIC Educational Resources Information Center

    Hollowell, Craig D.; McLaughlin, Ralph D.

    1973-01-01

    Describes the techniques which form the basis of current commercial instrumentation for monitoring five major gaseous atmospheric pollutants (sulfur dioxide, oxides of nitrogen, oxidants, carbon monoxide, and hydrocarbons). (JR)

  6. Instruments and attachments for electronystagmography

    NASA Technical Reports Server (NTRS)

    Mironenko, Y. T.; Vilenskiy, A. A.

    1980-01-01

    A portable set of instruments and devices was developed which makes it possible to record spontaneous nystagmus with open and closed eyes. Rotational, caloric, position, and pressure nystagmus under any conditions may also be recorded.

  7. Aircraft Power-Plant Instruments

    NASA Technical Reports Server (NTRS)

    Sontag, Harcourt; Brombacher, W G

    1934-01-01

    This report supersedes NACA-TR-129 which is now obsolete. Aircraft power-plant instruments include tachometers, engine thermometers, pressure gages, fuel-quantity gages, fuel flow meters and indicators, and manifold pressure gages. The report includes a description of the commonly used types and some others, the underlying principle utilized in the design, and some design data. The inherent errors of the instrument, the methods of making laboratory tests, descriptions of the test apparatus, and data in considerable detail in the performance of commonly used instruments are presented. Standard instruments and, in cases where it appears to be of interest, those used as secondary standards are described. A bibliography of important articles is included.

  8. HET0016, a Selective Inhibitor of 20-HETE Synthesis, Decreases Pro-Angiogenic Factors and Inhibits Growth of Triple Negative Breast Cancer in Mice

    PubMed Central

    Borin, Thaiz Ferraz; Zuccari, Debora A. P. C.; Jardim-Perassi, Bruna V.; Ferreira, Lívia C.; Iskander, A. S. M.; Varma, Nadimpalli Ravi S.; Shankar, Adarsh; Guo, Austin M.; Scicli, Guillermo; Arbab, Ali S.

    2014-01-01

    A selective inhibitor of 20-HETE synthesis, HET0016, has been reported to inhibit angiogenesis. 20-HETE has been known as a second mitogenic messenger of angiogenesis inducing growth factors. HET0016 effects were analyzed on MDA-MB-231 derived breast cancer in mouse and in vitro cell line. MDA-MB-231 tumor cells were implanted in animals’ right flank and randomly assigned to early (1 and 2), starting treatments on day 0, or delayed groups (3 and 4) on day 8 after implantation of tumor. Animals received HET0016 (10 mg/kg) treatment via intraperitoneal injection for 5 days/week for either 3 or 4 weeks. Control group received vehicle treatment. Tumor sizes were measured on days 7, 14, 21, and 28 and the animals were euthanized on day 22 and 29. Proteins were extracted from the whole tumor and from cells treated with 10 µM HET0016 for 4 and 24 hrs. Protein array kits of 20 different cytokines/factors were used. ELISA was performed to observe the HIF-1α and MMP-2 protein expression. Other markers were confirmed by IHC. HET0016 significantly inhibited tumor growth in all treatment groups at all-time points compared to control (p<0.05). Tumor growth was completely inhibited on three of ten animals on early treatment group. Treatment groups showed significantly lower expression of pro-angiogenic factors compared to control at 21 days; however, there was no significant difference in HIF-1α expression after treatments. Similar results were found in vitro at 24 hrs of HET0016 treatment. After 28 days, significant increase of angiogenin, angiopoietin-1/2, EGF-R and IGF-1 pro-angiogenic factors were found (p<0.05) compared to control, as well as an higher intensity of all factors were found when compared to that of 21 day’s data, suggesting a treatment resistance. HET0016 inhibited tumor growth by reducing expression of different set of pro-angiogenic factors; however, a resistance to treatment seemed to happen after 21 days. PMID:25549350

  9. HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice.

    PubMed

    Borin, Thaiz Ferraz; Zuccari, Debora A P C; Jardim-Perassi, Bruna V; Ferreira, Lívia C; Iskander, A S M; Varma, Nadimpalli Ravi S; Shankar, Adarsh; Guo, Austin M; Scicli, Guillermo; Arbab, Ali S

    2014-01-01

    A selective inhibitor of 20-HETE synthesis, HET0016, has been reported to inhibit angiogenesis. 20-HETE has been known as a second mitogenic messenger of angiogenesis inducing growth factors. HET0016 effects were analyzed on MDA-MB-231 derived breast cancer in mouse and in vitro cell line. MDA-MB-231 tumor cells were implanted in animals' right flank and randomly assigned to early (1 and 2), starting treatments on day 0, or delayed groups (3 and 4) on day 8 after implantation of tumor. Animals received HET0016 (10 mg/kg) treatment via intraperitoneal injection for 5 days/week for either 3 or 4 weeks. Control group received vehicle treatment. Tumor sizes were measured on days 7, 14, 21, and 28 and the animals were euthanized on day 22 and 29. Proteins were extracted from the whole tumor and from cells treated with 10 µM HET0016 for 4 and 24 hrs. Protein array kits of 20 different cytokines/factors were used. ELISA was performed to observe the HIF-1α and MMP-2 protein expression. Other markers were confirmed by IHC. HET0016 significantly inhibited tumor growth in all treatment groups at all-time points compared to control (p<0.05). Tumor growth was completely inhibited on three of ten animals on early treatment group. Treatment groups showed significantly lower expression of pro-angiogenic factors compared to control at 21 days; however, there was no significant difference in HIF-1α expression after treatments. Similar results were found in vitro at 24 hrs of HET0016 treatment. After 28 days, significant increase of angiogenin, angiopoietin-1/2, EGF-R and IGF-1 pro-angiogenic factors were found (p<0.05) compared to control, as well as an higher intensity of all factors were found when compared to that of 21 day's data, suggesting a treatment resistance. HET0016 inhibited tumor growth by reducing expression of different set of pro-angiogenic factors; however, a resistance to treatment seemed to happen after 21 days.

  10. Instrumentation Research and Support Services.

    DTIC Science & Technology

    1985-09-30

    to accomplish the tasks described below, as quoted from the above referenced section of the contractual docu ment: " Line Item 0001 - Provide...with the Contractor’s Technical Proposal Number EN81-R-62-Q, dated 81JAN02 and the following Sub- Line Items: Sub- Line Item OOO1AA - Instrument fifteen...Research Establish ment, A ustralia. 3 Sub- Line Item 0001A B - Provide services toward operating ground based instrumentation systems in support of

  11. 14 CFR 25.1337 - Powerplant instruments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Powerplant instruments. 25.1337 Section 25... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Instruments: Installation § 25.1337 Powerplant instruments. (a) Instruments and instrument lines. (1) Each powerplant and auxiliary power unit...

  12. CARMENES. IV: instrument control software

    NASA Astrophysics Data System (ADS)

    Guàrdia, Josep; Colomé, Josep; Ribas, Ignasi; Hagen, Hans-Jürgen; Morales, Rafael; Abril, Miguel; Galadí-Enríquez, David; Seifert, Walter; Sánchez Carrasco, Miguel A.; Quirrenbach, Andreas; Amado, Pedro J.; Caballero, Jose A.; Mandel, Holger

    2012-09-01

    The overall purpose of the CARMENES instrument is to perform high-precision measurements of radial velocities of late-type stars with long-term stability. CARMENES will be installed in 2014 at the 3.5 m telescope in the German- Spanish Astronomical Center at Calar Alto observatory (CAHA, Spain) and will be equipped with two spectrographs in the near-infrared and visible windows. The technology involved in such instrument represents a challenge at all levels. The instrument coordination and management is handled by the Instrument Control System (ICS), which is responsible of carrying out the operations of the different subsystems and providing a tool to operate the instrument from low to high user interaction level. The main goal of the ICS and the CARMENES control layer architecture is to maximize the instrument efficiency by reducing time overheads and by operating it in an integrated manner. The ICS implements the CARMENES operational design. A description of the ICS architecture and the application programming interfaces for low- and high-level communication is given. Internet Communications Engine is the technology selected to implement most of the interface protocols.

  13. The ESO Paranal instrumentation program

    NASA Astrophysics Data System (ADS)

    Pasquini, Luca

    2016-08-01

    The Paranal Instrumentation Programme is responsible for planning and delivering the instruments and the associated infrastructure needed to keep the VLT and La Silla Observatories at the forefront of ground-based astronomy. The VLT second generation instruments KMOS, MUSE and SPHERE have been delivered and are in operations, GRAVITY is under commissioning at the renewed VLTI facility. The Adapative Optics Facility is moving towards completion, as well as the high resolution spectrograph ESPRESSO and the VLTI second generation instrument MATISSE. The mid-IR imager and spectrograph VISIR has been upgraded, and a major upgrade of the CRIRES spectrograph is under way. Finally, two new Multi Object Spectrographs projects have started, one for the VLT (MOONS), one for the 4M VISTA telescope (4MOST), and two new instruments for La Silla, (SOXS and NIRPS) fully funded by the community, are being agreed. The Programme follows a roadmap that foresees one new instrument/project or one upgrade starting every year. Active management, cost to completion and risk policy are in place.

  14. High Data Rate Instrument Study

    NASA Technical Reports Server (NTRS)

    Schober, Wayne; Lansing, Faiza; Wilson, Keith; Webb, Evan

    1999-01-01

    The High Data Rate Instrument Study was a joint effort between the Jet Propulsion Laboratory (JPL) and the Goddard Space Flight Center (GSFC). The objectives were to assess the characteristics of future high data rate Earth observing science instruments and then to assess the feasibility of developing data processing systems and communications systems required to meet those data rates. Instruments and technology were assessed for technology readiness dates of 2000, 2003, and 2006. The highest data rate instruments are hyperspectral and synthetic aperture radar instruments which are capable of generating 3.2 Gigabits per second (Gbps) and 1.3 Gbps, respectively, with a technology readiness date of 2003. These instruments would require storage of 16.2 Terebits (Tb) of information (RF communications case of two orbits of data) or 40.5 Tb of information (optical communications case of five orbits of data) with a technology readiness date of 2003. Onboard storage capability in 2003 is estimated at 4 Tb; therefore, all the data created cannot be stored without processing or compression. Of the 4 Tb of stored data, RF communications can only send about one third of the data to the ground, while optical communications is estimated at 6.4 Tb across all three technology readiness dates of 2000, 2003, and 2006 which were used in the study. The study includes analysis of the onboard processing and communications technologies at these three dates and potential systems to meet the high data rate requirements. In the 2003 case, 7.8% of the data can be stored and downlinked by RF communications while 10% of the data can be stored and downlinked with optical communications. The study conclusion is that only 1 to 10% of the data generated by high data rate instruments will be sent to the ground from now through 2006 unless revolutionary changes in spacecraft design and operations such as intelligent data extraction are developed.

  15. Analytical techniques and instrumentation: A compilation

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Technical information on developments in instrumentation is arranged into four sections: (1) instrumentation for analysis; (2) analysis of matter; (3) analysis of electrical and mechanical phenomena; and (4) structural analysis. Patent information for two of the instruments described is presented.

  16. [Surgical instruments (II). An introduction to surgical instruments].

    PubMed

    Illana Esteban, Emilio

    2005-09-01

    In clinical practice, there are many diverse ways to name each instrument. Some names consist of local terms related to the shape or the use of an instrument; others have their origin in confusing references; few of these names tend to be related to known nomenclature. This causes a serious inconvenience for someone who wishes to learn about the intra-surgical medium in an organized manner. Undoubtedly this is an inconvenience for the untrained person who discovers he/she is incapable of retaining an enormous volume of names, often presented without any logic whatsoever This also causes an inconvenience for the trained professional; it is difficult to understand terms since, depending on which surgical ward one refers to, the name for the same instrument changes.

  17. On Representative Spaceflight Instrument and Associated Instrument Sensor Web Framework

    NASA Technical Reports Server (NTRS)

    Kizhner, Semion; Patel, Umeshkumar; Vootukuru, Meg

    2007-01-01

    Sensor Web-based adaptation and sharing of space flight mission resources, including those of the Space-Ground and Control-User communication segment, could greatly benefit from utilization of heritage Internet Protocols and devices applied for Spaceflight (SpaceIP). This had been successfully demonstrated by a few recent spaceflight experiments. However, while terrestrial applications of Internet protocols are well developed and understood (mostly due to billions of dollars in investments by the military and industry), the spaceflight application of Internet protocols is still in its infancy. Progress in the developments of SpaceIP-enabled instrument components will largely determine the SpaceIP utilization of those investments and acceptance in years to come. Likewise SpaceIP, the development of commercial real-time and instrument colocated computational resources, data compression and storage, can be enabled on-board a spacecraft and, in turn, support a powerful application to Sensor Web-based design of a spaceflight instrument. Sensor Web-enabled reconfiguration and adaptation of structures for hardware resources and information systems will commence application of Field Programmable Arrays (FPGA) and other aerospace programmable logic devices for what this technology was intended. These are a few obvious potential benefits of Sensor Web technologies for spaceflight applications. However, they are still waiting to be explored. This is because there is a need for a new approach to spaceflight instrumentation in order to make these mature sensor web technologies applicable for spaceflight. In this paper we present an approach in developing related and enabling spaceflight instrument-level technologies based on the new concept of a representative spaceflight Instrument Sensor Web (ISW).

  18. Facility instruments for the GTC

    NASA Astrophysics Data System (ADS)

    Rodriguez Espinosa, Jose M.; Garcia-Vargas, Maria Luisa; Hammersley, Peter L.

    2004-09-01

    The Gran Telescopio Canarias (GTC1) 10m telescope is now being integrated at the ORM, in La Palma Spain. Likewise, three instruments are being prepared for first light and, as of this writing, are about to start their laboratory integration. These first light instruments are: 1) OSIRIS, a large field of view imager and multi-object spectrograph, optimized for tuneable filter imaging, 2) ELMER a very sensitive imager and spectrograph, also for the visible range, and 3) CANARICAM, a diffraction-limited imager, spectrograph, polarimeter and coronagrapher for the mid-IR. The GTC set of first light instruments will offer some special observational capabilities to the astronomical community, namely Tuneable filter Imaging in OSIRIS, fast spectroscopy and photometry in both, ELMER and OSIRIS, and 10 microns Coronagraphy and Polarimetry with CANARICAM. Yet another instrument, EMIR, a large field, near-IR multi-object spectrograph and imager is in the Detailed Design phase. EMIR will be the first of the GTC second generation set of instruments. At the planning stage are several future instruments that will arrive to the GTC with different calendars after Day One. In particular, FRIDA, a near-IR diffraction-limited imager and spectrograph, that will operate with the GTC Adaptive Optics system. FRIDA's conceptual design is being started by a consortium lead by UNAM (Mexico) and in which the IAC and the University of Florida also participate. FRIDA should be at the telescope by the time that the AO system is having first light. This is expected by late 2007 early 2008. There is interest in the GTC community for installing visiting instruments on the GTC, thus the GTC board is discussing a policy to allow visitor instruments, some of which have already been proposed to be hosted by the GTC. In particular, CIRCE is a near IR camera that is being built by the Department of Astronomy of the University of Florida in Gainesville for the GTC using private funds, under the GTC visitor

  19. VLT Instruments Pipeline System Overview

    NASA Astrophysics Data System (ADS)

    Jung, Y.; Ballester, P.; Banse, K.; Hummel, W.; Izzo, C.; McKay, D. J.; Kiesgen, M.; Lundin, L. K.; Modigliani, A.; Palsa, R. M.; Sabet, C.

    2004-07-01

    Since the beginning of the VLT operations in 1998, substantial effort has been put in the development of automatic data reduction tools for the VLT instruments. A VLT instrument pipeline is a complex system that has to be able to identify and classify each produced FITS file, optionally retrieve calibration files from a database, use an image processing software to reduce the data, compute and log quality control parameters, produce FITS images or tables with the correct headers, optionally display them in the control room and send them to the archive. Each instrument has its own dedicated pipeline, based on a common infrastructure and installed with the VLT Data Flow System (DFS). With the increase in the number and the complexity of supported instruments and in the rate of produced data, these pipelines are becoming vital for both the VLT operations and the users, and request more and more resources for development and maintenance. This paper describes the different pipeline tasks with some real examples. It also explains how the development process has been improved to both decrease its cost and increase the pipelines quality using the lessons learned from the first instruments pipelines development.

  20. Register of Validated Short Dietary Assessment Instruments

    Cancer.gov

    The register contains descriptive information about the instruments identified (over 135) along with any associated validation studies and publications, and copies of the instruments themselves when available.

  1. [In Process Citation].

    PubMed

    Brand, H S

    2014-12-01

    Wetenschappelijk onderzoek, zoals elke maand beschreven in het Nederlands Tijdschrift voor Tandheelkunde, begint met een idee. Om het idee te kunnen onderzoeken is vervolgens geld nodig. Hierbij gaat het meestal om grote bedragen. Zo kost een promotieonderzoek van 4 jaar een paar ton aan salariskosten en materialen.

  2. ac-resistance-measuring instrument

    SciTech Connect

    Hof, P.J.

    1981-04-22

    An auto-ranging ac resistance measuring instrument for remote measurement of the resistance of an electrical device or circuit connected to the instrument includes a signal generator which generates an ac excitation signal for application to a load, including the device and the transmission line, a monitoring circuit which provides a digitally encoded signal representing the voltage across the load, and a microprocessor which operates under program control to provide an auto-ranging function by which range resistance is connected in circuit with the load to limit the load voltage to an acceptable range for the instrument, and an auto-compensating function by which compensating capacitance is connected in shunt with the range resistance to compensate for the effects of line capacitance.

  3. [Portable instrument for arteriosclerosis assessment].

    PubMed

    Cao, Shuai; Chen, Xiang

    2014-01-01

    A portable instrument for arteriosclerosis assessment containing sensor module, acquisition board and embedded module was developed for home care in this paper. The sensor module consists of one ECG module and three pulse wave extraction modules, synchronously acquiring human ECG and pulse wave signal of carotid, radial, and dorsal, respectively. The acquisition board converts the sensor module's analog output signals into digital signals and transmits them to the embedded module. The embedded module realizes the functions including signal display, storage and the calculation and output of pulse wave velocity. The structure of the proposed portable instrument is simple, easy to use, and easy to expand. Small size, low cost, and low power consumption are also the advantages of this device. Experimental results demonstrated that the proposed portable instrument for arteriosclerosis assessment has high accuracy, good repeatability and can assess the degree of atherosclerosis appropriately.

  4. Wide Field Instrument Adjutant Scientist

    NASA Astrophysics Data System (ADS)

    Spergel, David

    As Wide Field Instrument Adjutant Scientist, my goal will be to maximize the science capability of the mission in a cost-contained environment. I hope to work with the HQ, project and the FSWG to assure mission success. I plan to play a leadership role in communicating the WFIRST science capabilities to the astronomy community , obtain input from both science teams and the broader community that help derive performance requirements and calibration metrics. I plan to focus on developing the observing program for the deep fields and focus on using them to calibrate instrument performance and capabilities. I plan to organize workshops that will bring together WFIRST team members with astronomers working on LSST, Euclid, JWST, and the ELTs to maximize combined science return. I am also eager to explore the astrometric and stellar seismology capabilities of the instrument with a goal of maximizing science return without affecting science requirements.

  5. High-resolution instrumentation radar

    NASA Astrophysics Data System (ADS)

    Dydbal, Robert B.; Hurlbut, Keith H.; Mori, Tsutomu T.

    1987-03-01

    An instrumentation radar that uses a chirp waveform to achieve high-range resolution is described. High-range-resolution instrumentation radars evaluate the target response to operational waveforms used in high-performance radars and/or obtain a display of the individual target scattering mechanisms to better understand the scattering process. This particular radar was efficiently constructed from a combination of commercially available components and in-house fabricated circuitry. This instrumentation radar operates at X-band and achieves a 4.9-in-range resolution. A key feature of the radar is the combination of amplitude weighting with a high degree of waveform fidelity to achieve a very good range sidelobe performance. This range sidelobe performance is important to avoid masking lower level target returns in the range sidelobes of higher target returns.

  6. FTIR instrumentation for atmospheric observations

    NASA Astrophysics Data System (ADS)

    Knuteson, Robert O.; Revercomb, Henry E.; Best, Fred A.; Smith, William L.

    1993-09-01

    During the last six years, extensive observations of atmospheric emitted radiance in the spectral region from 3.6 - 20 micrometers with resolving powers of 1000 - 4000 have been made, both from the ground and nadir viewing from NASA high altitude aircraft. Two recent field experiments in which both instruments participated are the FIRE II/SPECTRE experiment Nov. - Dec. 1991 in Coffeyville, KS and the STORMFEST experiment Feb. - Mar. 1992 in Seneca, KS. Experience with these instruments has led to instrument designs for advanced sounders on geostationary and polar orbiting satellites. Applications include remote sensing of atmospheric temperature and water vapor for improved weather forecasting, measurement of cloud radiative impact for improvement of global climate modelling, and trace gas retrieval for climate and air pollution monitoring.

  7. Instrument performance enhancement and modification through an extended instrument paradigm

    NASA Astrophysics Data System (ADS)

    Mahan, Stephen Lee

    An extended instrument paradigm is proposed, developed and shown in various applications. The CBM (Chin, Blass, Mahan) method is an extension to the linear systems model of observing systems. In the most obvious and practical application of image enhancement of an instrument characterized by a time-invariant instrumental response function, CBM can be used to enhance images or spectra through a simple convolution application of the CBM filter for a resolution improvement of as much as a factor of two. The CBM method can be used in many applications. We discuss several within this work including imaging through turbulent atmospheres, or what we've called Adaptive Imaging. Adaptive Imaging provides an alternative approach for the investigator desiring results similar to those obtainable with adaptive optics, however on a minimal budget. The CBM method is also used in a backprojected filtered image reconstruction method for Positron Emission Tomography. In addition, we can use information theoretic methods to aid in the determination of model instrumental response function parameters for images having an unknown origin. Another application presented herein involves the use of the CBM method for the determination of the continuum level of a Fourier transform spectrometer observation of ethylene, which provides a means for obtaining reliable intensity measurements in an automated manner. We also present the application of CBM to hyperspectral image data of the comet Shoemaker-Levy 9 impact with Jupiter taken with an acousto-optical tunable filter equipped CCD camera to an adaptive optics telescope.

  8. Small Cold Temperature Instrument Packages

    NASA Astrophysics Data System (ADS)

    Clark, P. E.; Millar, P. S.; Yeh, P. S.; Feng, S.; Brigham, D.; Beaman, B.

    We are developing a small cold temperature instrument package concept that integrates a cold temperature power system with ultra low temperature ultra low power electronics components and power supplies now under development into a 'cold temperature surface operational' version of a planetary surface instrument package. We are already in the process of developing a lower power lower temperature version for an instrument of mutual interest to SMD and ESMD to support the search for volatiles (the mass spectrometer VAPoR, Volatile Analysis by Pyrolysis of Regolith) both as a stand alone instrument and as part of an environmental monitoring package. We build on our previous work to develop strategies for incorporating Ultra Low Temperature/Ultra Low Power (ULT/ULP) electronics, lower voltage power supplies, as well as innovative thermal design concepts for instrument packages. Cryotesting has indicated that our small Si RHBD CMOS chips can deliver >80% of room temperature performance at 40K (nominal minimum lunar surface temperature). We leverage collaborations, past and current, with the JPL battery development program to increase power system efficiency in extreme environments. We harness advances in MOSFET technology that provide lower voltage thresholds for power switching circuits incorporated into our low voltage power supply concept. Conventional power conversion has a lower efficiency. Our low power circuit concept based on 'synchronous rectification' could produce stable voltages as low as 0.6 V with 85% efficiency. Our distributed micro-battery-based power supply concept incorporates cold temperature power supplies operating with a 4 V or 8 V battery. This work will allow us to provide guidelines for applying the low temperature, low power system approaches generically to the widest range of surface instruments.

  9. Formation Flying and Deformable Instruments

    NASA Astrophysics Data System (ADS)

    Rio, Yvon

    2009-05-01

    Astronomers have always attempted to build very stable instruments. They fight all that can cause mechanical deformation or image motion. This has led to well established technologies (autoguide, active optics, thermal control, tip/tilt correction), as well as observing methods based on the use of controlled motion (scanning, micro scanning, shift and add, chopping and nodding). Formation flying disturbs this practice. It is neither possible to reduce the relative motion to very small amplitudes, nor to control it at will. Some impacts on Simbol-X instrument design, and operation are presented.

  10. Formation Flying and Deformable Instruments

    SciTech Connect

    Rio, Yvon

    2009-05-11

    Astronomers have always attempted to build very stable instruments. They fight all that can cause mechanical deformation or image motion. This has led to well established technologies (autoguide, active optics, thermal control, tip/tilt correction), as well as observing methods based on the use of controlled motion (scanning, micro scanning, shift and add, chopping and nodding). Formation flying disturbs this practice. It is neither possible to reduce the relative motion to very small amplitudes, nor to control it at will. Some impacts on Simbol-X instrument design, and operation are presented.

  11. Sample acquisition and instrument deployment

    NASA Technical Reports Server (NTRS)

    Boyd, Robert C.

    1995-01-01

    Progress is reported in developing the Sample Acquisition and Instrument Deployment (SAID) system, a robotic system for deploying science instruments and acquiring samples for analysis. The system is a conventional four degree of freedom manipulator 2 meters in length. A baseline design has been achieved through analysis and trade studies. The design considers environmental operating conditions on the surface of Mars, as well as volume constraints on proposed Mars landers. Control issues have also been studied, and simulations of joint and tip movements have been performed. The systems have been fabricated and tested in environmental chambers, as well as soil testing and robotic control testing.

  12. Instrumentation for air quality measurements.

    NASA Technical Reports Server (NTRS)

    Loewenstein, M.

    1973-01-01

    Comparison of the new generation of air quality monitoring instruments with some more traditional methods. The first generation of air quality measurement instruments, based on the use of oxidant coulometric cells, nitrogen oxide colorimetry, carbon monoxide infrared analyzers, and other types of detectors, is compared with new techniques now coming into wide use in the air monitoring field and involving the use of chemiluminescent reactions, optical absorption detectors, a refinement of the carbon monoxide infrared analyzer, electrochemical cells based on solid electrolytes, and laser detectors.

  13. Thermography instruments for predictive maintenance

    SciTech Connect

    Palko, E.

    1993-08-12

    Thermography (infrared imaging, or IR scanning) is not only the most versatile predictive maintenance technology available today; it is, in general, the most cost-effective. Plant engineering can apply a virtually unlimited variety of predictive maintenance instruments, but all are restricted regarding the types of existing and incipient problems they can detect. Inplant applications of thermography, however, are truly limited only by the extent of the plant engineer's imagination. Here are ways that thermography can be used to fight downtime in plants, and factors to consider when selecting the best instrument for particular circumstances.

  14. Pascal Software voor CO2-Laserradar Afstandsmetingen met de HP9000 (Pascal Software for CO2-Laserradar Ranging with a HP9000 Computer)

    DTIC Science & Technology

    1991-09-01

    11 2.2 Int.-m’e M(Auies 12 2.3 Exte-’-, ’J-ules 13 2.3.1 Sys~cm Y~odules 13 2.3.2 Non Systein~ Modules 14 2.3.2.1 Digitale Integrator, XY Scanner en...ten behoeve van randatpparatuur 20 3.1.1 VIDIS 21 3.1.2 XY Scanner 22 3.1.3 HF Signaalverwerker 23 3.1.4 Digitale integrator 23 TNO rapport Pagina 5 3.2...meetmodules en de extemne modules voor de digitale integrator (de averager), XY scanner en de HF signaal- verwerker. 2.1 Meetmodules Meetmodules zijrn

  15. Instrumentation System Diagnoses a Thermocouple

    NASA Technical Reports Server (NTRS)

    Perotti, Jose; Santiago, Josephine; Mata, Carlos; Vokrot, Peter; Zavala, Carlos; Burns, Bradley

    2008-01-01

    An improved self-validating thermocouple (SVT) instrumentation system not only acquires readings from a thermocouple but is also capable of detecting deterioration and a variety of discrete faults in the thermocouple and its lead wires. Prime examples of detectable discrete faults and deterioration include open- and short-circuit conditions and debonding of the thermocouple junction from the object, the temperature of which one seeks to measure. Debonding is the most common cause of errors in thermocouple measurements, but most prior SVT instrumentation systems have not been capable of detecting debonding. The improved SVT instrumentation system includes power circuitry, a cold-junction compensator, signal-conditioning circuitry, pulse-width-modulation (PWM) thermocouple-excitation circuitry, an analog-to-digital converter (ADC), a digital data processor, and a universal serial bus (USB) interface. The system can operate in any of the following three modes: temperature measurement, thermocouple validation, and bonding/debonding detection. The software running in the processor includes components that implement statistical algorithms to evaluate the state of the thermocouple and the instrumentation system. When the power is first turned on, the user can elect to start a diagnosis/ monitoring sequence, in which the PWM is used to estimate the characteristic times corresponding to the correct configuration. The user also has the option of using previous diagnostic values, which are stored in an electrically erasable, programmable read-only memory so that they are available every time the power is turned on.

  16. Remote Instrumentation for Teaching Laboratory

    ERIC Educational Resources Information Center

    Baran, Jit; Currie, Ron; Kennepohl, Dietmar

    2004-01-01

    The feasibility of using current software, such as PC-Duo, PCAnywhere or LabVIEW, in training students in instrumental analysis from a remote location is investigated. Findings show that creation of online features is crucial to the use and learning by students and the development of a suitable Web site, which provides an easy-to-use interface to…

  17. Geoscience experiments in boreholes: instrumentation

    SciTech Connect

    Traeger, R.K.

    1984-05-01

    Drilling is the only method available to obtain unambiguous information on processes occurring in the earth's crust. When core and virgin formation fluid samples are available, the geological state of the formation may be defined in the vicinity of the borehole with little ambiguity. Unfortunately, core recovery is expensive and often not complete, and drilling muds contaminate formation fluids. Thus, investigations turn to downhole instrumentation systems to evaluate in situ formation parameters. Some such instruments and the associated interpretative techniques are well developed, especially if they find usage in the evaluation of hydrocarbon reservoirs. Other sytems, particularly those that yield geochemical information are, at best, shallow-hole devices, but they could be engineered for deep-hole applications. Interpretations of logs obtained in igneous and metamorphic systems are not well developed. Finally, measurements away from the immediate vicinity of the borehole are possible but the technology is primitive. In situ instrumentation capabilities and needs for research in boreholes will be reviewed; the review will include details from recent US and European discussions of instrumentation needs. The capability and availability of slim hole logging tools will be summarized. Temperature limitations of the overall logging system will be discussed (current limits are 300/sup 0/C) and options for measurements to 500/sup 0/C will be described.

  18. Analysis of Key Education Instrumentation.

    ERIC Educational Resources Information Center

    Penfield, Douglas A.; And Others

    The Key Assessment System, consisting of test instruments which measure psychological functioning, work related competencies, and attitudinal and motivational characteristics, is described. The system is a vocational assessment battery designed to differentiate levels of psychophysical capabilities in a nondiscriminatory manner. It provides a…

  19. Vacuum Enhanced Cutaneous Biopsy Instrument

    SciTech Connect

    Collins, Joseph

    1999-06-25

    A syringe-like disposable cutaneous biopsy instrument equipped with a tubular blade at its lower end, and designed so that a vacuum is created during use, said vacuum serving to retain undeformed a plug of tissue cut from a patient's skin.

  20. Personal Computer Monitors Instrumentation Bus

    NASA Technical Reports Server (NTRS)

    Conroy, Bruce L.

    1994-01-01

    IBM-compatible personal computer used instead of logic analyzer or other special instrument to monitor IEEE-488 interface data bus that interconnects various pieces of laboratory equipment. Needed is short program for computer, commercial general-purpose interface bus circuit card, and adapter cable to link card to bus. Software available in Ada or Quick Basic language.

  1. Experimenting with Brass Musical Instruments.

    ERIC Educational Resources Information Center

    LoPresto, Michael C.

    2003-01-01

    Describes experiments to address the properties of brass musical instruments that can be used to demonstrate sound in any level physics course. The experiments demonstrate in a quantitative fashion the effects of the mouthpiece and bell on the frequencies of sound waves and thus the musical pitches produced. (Author/NB)

  2. Air Quality Instrumentation. Volume 2.

    ERIC Educational Resources Information Center

    Scales, John W., Ed.

    To insure a wide dissemination of information describing advances in measurement and control techniques, the Instrument Society of America (ISA) has published this monograph of selected papers, the second in a series, from recent ISA symposia dealing with air pollution. Papers range from a discussion of individual pollutant measurements to…

  3. Instrumental Surveillance of Water Quality.

    ERIC Educational Resources Information Center

    Miller, J. A.; And Others

    The role analytical instrumentation performs in the surveillance and control of the quality of water resources is reviewed. Commonly performed analyses may range from simple tests for physical parameters to more highly sophisticated radiological or spectrophotometric methods. This publication explores many of these types of water quality analyses…

  4. Psychology Needs Realism, Not Instrumentalism

    ERIC Educational Resources Information Center

    Haig, Brian D.

    2005-01-01

    In this article, the author presents his comments on "Realism, Instrumentalism, and Scientific Symbiosis: Psychological Theory as a Search for Truth and the Discovery of Solutions" by John T. Cacioppo, Gun R. Semin and Gary G. Berntson. In the original article, the authors recommended the combined use of the philosophies of scientific realism and…

  5. Instrument independent diffuse reflectance spectroscopy.

    PubMed

    Yu, Bing; Fu, Henry L; Ramanujam, Nirmala

    2011-01-01

    Diffuse reflectance spectroscopy with a fiber optic probe is a powerful tool for quantitative tissue characterization and disease diagnosis. Significant systematic errors can arise in the measured reflectance spectra and thus in the derived tissue physiological and morphological parameters due to real-time instrument fluctuations. We demonstrate a novel fiber optic probe with real-time, self-calibration capability that can be used for UV-visible diffuse reflectance spectroscopy in biological tissue in clinical settings. The probe is tested in a number of synthetic liquid phantoms over a wide range of tissue optical properties for significant variations in source intensity fluctuations caused by instrument warm up and day-to-day drift. While the accuracy for extraction of absorber concentrations is comparable to that achieved with the traditional calibration (with a reflectance standard), the accuracy for extraction of reduced scattering coefficients is significantly improved with the self-calibration probe compared to traditional calibration. This technology could be used to achieve instrument-independent diffuse reflectance spectroscopy in vivo and obviate the need for instrument warm up and post∕premeasurement calibration, thus saving up to an hour of precious clinical time.

  6. Air Quality Instrumentation. Volume 1.

    ERIC Educational Resources Information Center

    Scales, John W., Ed.

    To insure a wide dissemination of information describing advances in measurement and control techniques, the Instrument Society of America (ISA) has published this monograph of selected papers from recent ISA symposia dealing with air pollution. Papers range from a discussion of some relatively new applications of proven techniques to discussions…

  7. Literature Review of Multicultural Instrumentation

    ERIC Educational Resources Information Center

    Sarraj, Huda; Carter, Stacy; Burley, Hansel

    2015-01-01

    Demographic changes at the national level emphasize a critical need for multicultural education to be included as part of undergraduate education. This critical review of the literature examines 10 multicultural instruments that are suitable for use in K-12 or higher education institutions. This is a novel literature review in that it is the first…

  8. Mobile Instruments Measure Atmospheric Pollutants

    NASA Technical Reports Server (NTRS)

    2009-01-01

    As a part of NASA's active research of the Earth s atmosphere, which has included missions such as the Atmospheric Laboratory of Applications and Science (ATLAS, launched in 1992) and the Total Ozone Mapping Spectrometer (TOMS, launched on the Earth Probe satellite in 1996), the Agency also performs ground-based air pollution research. The ability to measure trace amounts of airborne pollutants precisely and quickly is important for determining natural patterns and human effects on global warming and air pollution, but until recent advances in field-grade spectroscopic instrumentation, this rapid, accurate data collection was limited and extremely difficult. In order to understand causes of climate change and airborne pollution, NASA has supported the development of compact, low power, rapid response instruments operating in the mid-infrared "molecular fingerprint" portion of the electromagnetic spectrum. These instruments, which measure atmospheric trace gases and airborne particles, can be deployed in mobile laboratories - customized ground vehicles, typically - to map distributions of pollutants in real time. The instruments must be rugged enough to operate rapidly and accurately, despite frequent jostling that can misalign, damage, or disconnect sensitive components. By measuring quickly while moving through an environment, a mobile laboratory can correlate data and geographic points, revealing patterns in the environment s pollutants. Rapid pollutant measurements also enable direct determination of pollutant sources and sinks (mechanisms that remove greenhouse gases and pollutants), providing information critical to understanding and managing atmospheric greenhouse gas and air pollutant concentrations.

  9. Vacuum enhanced cutaneous biopsy instrument

    DOEpatents

    Collins, Joseph

    2000-01-01

    A syringe-like disposable cutaneous biopsy instrument equipped with a tubular blade at its lower end, and designed so that a vacuum is created during use, said vacuum serving to retain undeformed a plug of tissue cut from a patient's skin.

  10. The MUSE instrument detector system

    NASA Astrophysics Data System (ADS)

    Reiss, Roland; Deiries, Sebastian; Lizon, Jean-Louis; Rupprecht, Gero

    2012-09-01

    The MUSE (Multi Unit Spectroscopic Explorer) instrument (see Bacon et al., this conference) for ESO's Very Large Telescope VLT employs 24 integral field units (spectrographs). Each of these is equipped with its own cryogenically cooled CCD head. The heads are individually cooled by continuous flow cryostats. The detectors used are deep depletion e2v CCD231-84 with 4096x4112 active 15 μm pixels. The MUSE Instrument Detector System is now in the final integration and test phase on the instrument. This paper gives an overview of the architecture and performance of the complex detector system including ESO's New General detector Controllers (NGC) for the 24 science detectors, the detector head electronics and the data acquisition system with Linux Local Control Units. NGC is sub-divided into 4 Detector Front End units each operating 6 CCDs. All CCDs are simultaneously read out through 4 ports to achieve short readout times at low noise levels. All science grade CCDs were thoroughly characterized on ESO's optical detectors testbench facility and the test results processed and documented in a semi-automated, reproducible way. We present the test methodology and the results that fully confirm the feasibility of these detectors for their use in this challenging instrument.

  11. 14 CFR 121.307 - Engine instruments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Engine instruments. 121.307 Section 121.307..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.307 Engine instruments. Unless the Administrator allows or requires different instrumentation for turbine engine...

  12. 14 CFR 121.307 - Engine instruments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Engine instruments. 121.307 Section 121.307..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.307 Engine instruments. Unless the Administrator allows or requires different instrumentation for turbine engine...

  13. 14 CFR 121.307 - Engine instruments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Engine instruments. 121.307 Section 121.307..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.307 Engine instruments. Unless the Administrator allows or requires different instrumentation for turbine engine...

  14. 40 CFR 1066.120 - Measurement instruments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Measurement instruments. 1066.120... CONTROLS VEHICLE-TESTING PROCEDURES Equipment, Measurement Instruments, Fuel, and Analytical Gas Specifications § 1066.120 Measurement instruments. The measurement instrument requirements in 40 CFR part...

  15. Instrument Reporting Practices in Second Language Research

    ERIC Educational Resources Information Center

    Derrick, Deirdre J.

    2016-01-01

    Second language (L2) researchers often have to develop or change the instruments they use to measure numerous constructs (Norris & Ortega, 2012). Given the prevalence of researcher-developed and -adapted data collection instruments, and given the profound effect instrumentation can have on results, thorough reporting of instrumentation is…

  16. 14 CFR 23.1381 - Instrument lights.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Instrument lights. 23.1381 Section 23.1381... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Equipment Lights § 23.1381 Instrument lights. The instrument lights must— (a) Make each instrument and control easily readable and...

  17. 14 CFR 25.1381 - Instrument lights.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Instrument lights. 25.1381 Section 25.1381... STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1381 Instrument lights. (a) The instrument lights must— (1) Provide sufficient illumination to make each instrument, switch and other...

  18. 14 CFR 25.1381 - Instrument lights.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Instrument lights. 25.1381 Section 25.1381... STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1381 Instrument lights. (a) The instrument lights must— (1) Provide sufficient illumination to make each instrument, switch and other...

  19. 14 CFR 25.1381 - Instrument lights.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Instrument lights. 25.1381 Section 25.1381... STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1381 Instrument lights. (a) The instrument lights must— (1) Provide sufficient illumination to make each instrument, switch and other...

  20. 14 CFR 25.1381 - Instrument lights.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Instrument lights. 25.1381 Section 25.1381... STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1381 Instrument lights. (a) The instrument lights must— (1) Provide sufficient illumination to make each instrument, switch and other...

  1. 14 CFR 121.307 - Engine instruments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Engine instruments. 121.307 Section 121.307..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.307 Engine instruments. Unless the Administrator allows or requires different instrumentation for turbine engine...

  2. 14 CFR 121.307 - Engine instruments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Engine instruments. 121.307 Section 121.307..., FLAG, AND SUPPLEMENTAL OPERATIONS Instrument and Equipment Requirements § 121.307 Engine instruments. Unless the Administrator allows or requires different instrumentation for turbine engine...

  3. Sonic instruments in root canal therapy.

    PubMed

    Waplington, M; Lumley, P J; Walmsley, A D

    1995-10-01

    Although hand instrumentation is considered the most acceptable method of preparing root canals, sonic instruments may be useful additions to the endodontic armamentarium. Sonic instrumentation may be incorporated as an adjunct to traditional techniques for shaping the root canal. The use of such instruments may assist the practitioner during root canal treatment in general practice.

  4. 14 CFR 25.1381 - Instrument lights.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Instrument lights. 25.1381 Section 25.1381... STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Lights § 25.1381 Instrument lights. (a) The instrument lights must— (1) Provide sufficient illumination to make each instrument, switch and other...

  5. Concurrent Validity of Four Androgyny Instruments.

    ERIC Educational Resources Information Center

    Wilson, F. Robert; Cook, Ellen Piel

    1984-01-01

    Compares concurrent validity of four sex-role instruments administered to a group of 281 urban university students. Reports that the instruments are sufficiently different in their measurement characteristics to warrant limiting generalizations about behavior based on these instruments to a particular instrument being used. (KH)

  6. 21 CFR 882.4525 - Microsurgical instrument.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Microsurgical instrument. 882.4525 Section 882...) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Surgical Devices § 882.4525 Microsurgical instrument. (a) Identification. A microsurgical instrument is a nonpowered surgical instrument used in neurological...

  7. 32 CFR 21.665 - Nonprocurement instrument.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Nonprocurement instrument. 21.665 Section 21.665... REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Definitions § 21.665 Nonprocurement instrument. A legal instrument other than a procurement contract. Examples include instruments of financial assistance, such...

  8. 14 CFR 29.1333 - Instrument systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Instrument systems. 29.1333 Section 29.1333... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Instruments: Installation § 29.1333 Instrument systems. For systems that operate the required flight instruments which are located at each pilot's...

  9. 21 CFR 882.4525 - Microsurgical instrument.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Microsurgical instrument. 882.4525 Section 882...) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Surgical Devices § 882.4525 Microsurgical instrument. (a) Identification. A microsurgical instrument is a nonpowered surgical instrument used in neurological...

  10. 14 CFR 25.1333 - Instrument systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Instrument systems. 25.1333 Section 25.1333... STANDARDS: TRANSPORT CATEGORY AIRPLANES Equipment Instruments: Installation § 25.1333 Instrument systems. For systems that operate the instruments required by § 25.1303(b) which are located at each...

  11. Development and application of a simultaneous SPE-method for polycyclic aromatic hydrocarbons (PAHs), alkylated PAHs, heterocyclic PAHs (NSO-HET) and phenols in aqueous samples from German Rivers and the North Sea.

    PubMed

    Siemers, Anne-Kathrin; Mänz, Jan Sebastian; Palm, Wolf-Ulrich; Ruck, Wolfgang K L

    2015-03-01

    Polycyclic aromatic hydrocarbons (PAHs), heterocyclic PAHs (NSO-HETs), alkylated PAHs and phenols are known as the prevailing contaminants in groundwater at tar contaminated sites. Besides these local sources, the concentrations and the distribution in particular of NSO-HETs in environmental samples, such as rivers, have received notably less attention. To investigate their occurrence in river basins two sensitive analytical methods for the simultaneous extraction of 86 substances including NSO-HETs, classical EPA-PAHs, alkylated PAHs and phenols were developed: liquid-liquid extraction for the whole water phase and solid phase extraction for the dissolved water phase only. Solely GC-MS or additionally LC-MSMS for fractionated basic nitrogen heterocycles (N-HETs) were used for quantification. Limits of quantification were in the low ngL(-1) range. Concentrations were determined in 29 aqueous samples from 8 relatively large rivers located in Lower Saxony (Germany) and the North Sea. NSO-HETs had comparable or even higher sum concentrations than EPA-PAHs. N-HETs, especially acridine and quinolines with concentrations of up to 20ngL(-1) per substance, were predominant.

  12. ACRF Instrumentation Status and Information July 2009

    SciTech Connect

    JW Voyles

    2009-08-13

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  13. ACRF Instrumentation Status and Information May 2009

    SciTech Connect

    JW Voyles

    2009-05-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  14. ACRF Instrumentation Status and Information - June 2009

    SciTech Connect

    JW Voyles

    2009-06-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  15. ACRF Instrumentation Status and Information April 2009

    SciTech Connect

    Voyles, JW

    2009-05-07

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  16. ACRF Instrumentation Status and Information August 2009

    SciTech Connect

    JW Voyles

    2009-09-09

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  17. ACRF Instrumentation Status and Information September 2009

    SciTech Connect

    JW Voyles

    2009-10-01

    The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement Climate Research Facility instrumentation status. The report is divided into the following five sections: (1) new instrumentation in the process of being acquired and deployed, (2) field campaigns, (3) existing instrumentation and progress on improvements or upgrades, (4) proposed future instrumentation, and (5) Small Business Innovation Research instrument development.

  18. Critiquing research instruments for postanesthesia studies.

    PubMed

    Summers, S

    1993-06-01

    A recent series of articles instructed PACU nurses on steps in developing pencil-and-paper instruments for research studies. What questions should PACU nurses ask when considering the use of existing pencil-and-paper instruments for use in research studies? The purpose of this article is to present nine steps in critiquing existing instrument before conducting research studies. Included are ethical considerations when using instruments and a checklist to assist PACU nurses in critiquing existing instruments.

  19. Metal-free sp3 C-H bond dual-(het)arylation: I2-promoted domino process to construct 2,2-bisindolyl-1-arylethanones.

    PubMed

    Zhu, Yan-ping; Liu, Mei-cai; Jia, Feng-cheng; Yuan, Jing-jing; Gao, Qing-he; Lian, Mi; Wu, An-xin

    2012-07-06

    A molecular I(2)-promoted sp(3) C-H bond dual-(het)arylation protocol was developed for the synthesis of 2,2-bisindolyl-1-arylethanones. Through a logical design, three mechanism-different reactions (iodination, Kornblum oxidation, and Friedel-Crafts reaction) were assembled in a single reactor. A variety of 2,2-bisindolyl-1-aryl ethanones were synthesized from simple and readily available aryl methyl ketones and indoles. In the reaction, metal, base, and ligand were all avoidable.

  20. Applicability and robustness of the hen's egg test for analysis of micronucleus induction (HET-MN): results from an inter-laboratory trial.

    PubMed

    Greywe, Daniela; Kreutz, Jürgen; Banduhn, Norbert; Krauledat, Matthias; Scheel, Julia; Schroeder, Klaus R; Wolf, Thorsten; Reisinger, Kerstin

    2012-08-30

    The hen's egg test for analysis of micronucleus formation (HET-MN) was developed several years ago to provide an alternative test system to the in vivo micronucleus test. In order to assess its applicability and robustness, a study was carried out at the University of Osnabrueck (lab A) and at the laboratories of Henkel AG & Co. KGaA (lab B). Following transfer of the method to lab B, a range of test substances that had been pre-tested at lab A, were tested at Henkel: the genotoxins cyclophosphamide, dimethylbenz(a)anthracene, methotrexate, acrylamide, azorubin, N-nitroso-dimethylamine and the non-genotoxins, orange G and isopropyl myristate. In a second phase, additional compounds with known in vivo properties were examined in both labs: the non-genotoxin, ampicillin, the "irrelevant" positives, isophorone and 2,4-dichlorophenol ("irrelevant" means positive in standard in vitro tests, but negative in vivo), the clastogen p-chloroaniline, and the aneugens carbendazim and vinorelbine. All substances were correctly predicted in both labs with respect to their in vivo genotoxic properties, indicating that the HET-MN may have an improved predictivity compared with current standard in vitro test systems. The results support the promising role of the HET-MN assay as a supplement to existing test batteries.

  1. Vrouwen bij de Koninklijke Landmacht: Een Onderzoek naar de Maatregelen die het Behoud en de Doorstroom van Vrouwelijke Militairen Verbeteren (Women in the Royal Netherlands Army: Measures for Retention and Career Development)

    DTIC Science & Technology

    2007-02-01

    op bet werk befnvloedt de werkbeleving en tevredenbeid van werknemers. Ret werk is immers niet alleen een manier om geld te verdienen. maar ook een...arbeidskracht. Als de organisatie daadwerkelijk belang hecht aan combinatiemnogelijkheden van werk en priv6, moet daar ook tijd en geld voor vrijgemaakt

  2. High-resolution instrumentation radar

    NASA Astrophysics Data System (ADS)

    Dybdal, Robert B.; Hurlbut, Keith H.; Mori, Tsutomu T.

    1986-09-01

    The development of an instrumentation radar that uses a chirp waveform to achieve high range resolution is described. Such range resolution capability is required for two reasons: (1) to evaluate the response of targets to the operational waveforms used in high-performance radars; and (2) to obtain a means of separating the individual mechanisms that comprise the target scattering response to better understand the scattering process. This particular radar was efficiently constructed from a combination of commercially available components and in-house-fabricated circuitry. This instrumentation radar operates at X-band and achieves a 4.9-in. range resolution. A key feature of the radar is its ability to combine amplitude weighting with a high degree of waveform fidelity, with the result being very good range sidelobe performance.

  3. Dual physiological rate measurement instrument

    NASA Technical Reports Server (NTRS)

    Cooper, Tommy G. (Inventor)

    1990-01-01

    The object of the invention is to provide an instrument for converting a physiological pulse rate into a corresponding linear output voltage. The instrument which accurately measures the rate of an unknown rectangular pulse wave over an extended range of values comprises a phase-locked loop including a phase comparator, a filtering network, and a voltage-controlled oscillator, arranged in cascade. The phase comparator has a first input responsive to the pulse wave and a second input responsive to the output signal of the voltage-controlled oscillator. The comparator provides a signal dependent on the difference in phase and frequency between the signals appearing on the first and second inputs. A high-input impedance amplifier accepts an output from the filtering network and provides an amplified output DC signal to a utilization device for providing a measurement of the rate of the pulse wave.

  4. Systematic Differences Between Radiosonde Instruments

    NASA Technical Reports Server (NTRS)

    Lait, Leslie R.; Bhartia, P. K. (Technical Monitor)

    2001-01-01

    Deviations of radiosonde reports' geopotential heights from the zonal mean are examined. In the summer Northern Hemisphere stratosphere, systematic differences are found between radiosonde instrument types. Persistent meridional wind anomalies, approximately constant in magnitude and fixed in location, have previously been reported in the summer stratosphere, and one such anomaly over Europe is found to be co-located with boundaries between regions in which differing types of radiosonde instruments are used. The magnitude and orientation of the radiosonde geopotential height biases are consistent with the wind anomalies. Because the overall winds tend to be light in this region and season, these wind anomalies can represent significant perturbations of the flow and must be considered when interpreting the results of trajectory and diagnostic studies.

  5. Recent developments in hydrologic instrumentation

    USGS Publications Warehouse

    Latkovich, Vito J.; Futrell, James C.; Kane, Douglas L.

    1986-01-01

    The programs of the U.S. Geological Survey require instrumentation for collecting and monitoring hydrologic data in cold regions. The availability of space-age materials and implementation of modern electronics and mechanics is making possible the recent developments of hydrologic instrumentation, especially in the area of measuring streamflow under ice cover. Material developments include: synthetic-fiber sounding and tag lines; polymer (plastic) sheaves, pulleys, and sampler components; and polymer (plastic) current-meter bucket wheels. Electronic and mechanical developments include: a current-meter digitizer; a fiber-optic closure system for current-meters; non-contact water-level sensors; an adaptable hydrologic data acquisition system; a minimum data recorder; an ice rod; an ice foot; a handled sediment sampler; a light weight ice auger with improved cutter head and blades; and an ice chisel.

  6. Instrumented fuels test for FFTF

    SciTech Connect

    Feigenbutz, L.V.; Hoth, C.W.

    1980-01-01

    In support of the LMFBR Fuels Development Program, Hanford Engineering Development Laboratory (HEDL) has designed the Fuels Open Test Assembly (FOTA) for fuels testing at the Fast Flux Test Facility (FFTF). The FOTA is a test vehicle designed to contain and support instrumented fuel experiments in the Fast Test Reactor (FTR) at FFTF. The initial two FOTA experiments will characterize the reference Driver Fuel Assembly performance in the FTR and provide experimental data to evaluate thermohydraulic models used to predict assembly performance. The design features and fabrication are described for the first two FOTA instrumented fuel experiments, which have been fabricated and are now in the FTR. A brief description of the FOTA test vehicle is included.

  7. The USNA MIDN Microdosimeter Instrument

    NASA Technical Reports Server (NTRS)

    Pisacane, V. L.; Ziegler, J. F.; Nelson, M. E.; Dolecek, Q.; Heyne, J.; Veade, T.; Rosenfeld, A. B.; Cucinotta, F. A.; Zaider, M.; Dicello, J. F.

    2006-01-01

    This paper describes the MIcroDosimetry iNstrument (MIDN) mission now under development at the United States Naval Academy. The instrument is manifested to fly on the MidSTAR-1 spacecraft, which is the second spacecraft to be developed and launched by the Academy s faculty and midshipmen. Launch is scheduled for 1 September 2006 on an ATLAS-5 launch vehicle. MIDN is a rugged, portable, low power, low mass, solid-state microdosimeter designed to measure in real time the energy distributions of energy deposited by radiation in microscopic volumes. The MIDN microdosimeter sensor is a reverse-biased silicon p-n junction array in a Silicon-On-Insulator (SOI) configuration. Microdosimetric frequency distributions as a function of lineal energies determine the radiation quality factors in support of radiation risk estimation to humans.

  8. In Situ Instruments: Overview of In Situ Instruments for Deployment in Extreme Environments

    NASA Technical Reports Server (NTRS)

    Taylor, M.; Cardell, G.

    2000-01-01

    This presentation reviews the design and specifications for several instruments for deployment in extreme environments. The instruments are: (1) In Situ Geochronology Instrument, (2) Laser Ablation Sampling Instrument, (3) Micro Hygrometer (4) Micro Lidar, (5) Atmospheric Electron X-Ray Spectrometer and (6) Nuclear Magnetic Resonance Spectrometer. Included in the descriptions are the contact people and the objective of each instrument.

  9. Video instrumentation for radionuclide angiocardiography.

    NASA Technical Reports Server (NTRS)

    Kriss, J. P.

    1973-01-01

    Two types of videoscintiscopes for performing radioisotopic angiocardiography with a scintillation camera are described, and use of these instruments in performing clinical studies is illustrated. Radionuclide angiocardiography is a simple, quick and accurate procedure recommended as a screening test for patients with a variety of congenital and acquired cardiovascular lesions. When performed in conjunction with coronary arterial catheterization, dynamic radionuclide angiography may provide useful information about regional myocardial perfusion. Quantitative capabilities greatly enhance the potential of this diagnostic tool.

  10. LANDSAT D instrument module study

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Spacecraft instrument module configurations which support an earth resource data gathering mission using a thematic mapper sensor were examined. The differences in size of these two experiments necessitated the development of two different spacecraft configurations. Following the selection of the best-suited configurations, a validation phase of design, analysis and modelling was conducted to verify feasibility. The chosen designs were then used to formulate definition for a systems weight, a cost range for fabrication and interface requirements for the thematic mapper (TM).

  11. The Instruments of Dudley Observatory

    NASA Astrophysics Data System (ADS)

    Gino, M. C.

    2002-12-01

    Dudley Observatory, founded in 1852, is the nation's oldest independent organization dedicated to astronomical research and education. While Dudley no longer operates a physical observatory, it is home to a number of historically important scientific instruments and telescopes. Dudley's first operating telescope, a Clark Comet-seeker, remains in Dudley's collection today. This 4-inch refractor provided the first discovery of a comet by a Dudley astronomer in 1857 and is one of only four telescopes of this size produced by Alvan Clark. Also in Dudley's collection is the Olcott Meridian Circle which was the primary working telescope at the observatory for over 75 years. This telescope, made by Pistor & Martins and which operated both at the Dudley Observatory in Albany, NY and the San Luis Observatory in Argentina, was used to conduct all of the observations for the Preliminary General Catalog of 6788 Stars (1908) and the General Catalog of 33,343 Stars (1937). The gem of Dudley's collection is the Pruyn Equatorial Telescope, built by the Warner and Swasey Company and equipped with a 12-inch lens made by John Brashear. It was installed in 1893 to conduct both research observations and public observing sessions. After remaining in storage for many decades, this historic telescope will soon resume its role after being refurbished and installed at the Arunah Hill Natural Science Center in Cummington, MA. While Dudley retains its interest in astronomical instruments it has also moved into the areas of space studies and astronomical education. The key projects in the areas of instrumentation and astronomical outreach, which include the instruments above as well as the Rising Star Internship and Space Campership educational programs, will be detailed in the remainder of this paper.

  12. Airborne Meteorological and Turbulence Instrumentation

    DTIC Science & Technology

    2016-06-07

    PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) University of California, Irvine,Departments of Mechanical Engineering and Earth System Science,Irvine,CA...Science University of California, Irvine Irvine, CA 92697-3975 (949) 824-6259 fax (949) 824-2249 email: cfriehe@uci.edu Award #: N000149910733 http...marine boundary layer through experiments. A Defense University Research Instrumentation Proposal (DURIP) was funded to provide specialized

  13. SMAP Instrument Mechanical System Engineering

    NASA Technical Reports Server (NTRS)

    Slimko, Eric; French, Richard; Riggs, Benjamin

    2013-01-01

    The Soil Moisture Active Passive (SMAP) mission, scheduled for launch by the end of 2014, is being developed to measure the soil moisture and soil freeze/thaw state on a global scale over a three-year period. The accuracy, resolution, and global coverage of SMAP measurements are invaluable across many science and applications disciplines including hydrology, climate, carbon cycle, and the meteorological, environment, and ecology applications communities. The SMAP observatory is composed of a despun bus and a spinning instrument platform that includes both a deployable 6 meter aperture low structural frequency Astromesh reflector and a spin control system. The instrument section has engendered challenging mechanical system issues associated with the antenna deployment, flexible antenna pointing in the context of a multitude of disturbances, spun section mass properties, spin control system development, and overall integration with the flight system on both mechanical and control system levels. Moreover, the multitude of organizations involved, including two major vendors providing the spin subsystem and reflector boom assembly plus the flight system mechanical and guidance, navigation, and control teams, has led to several unique system engineering challenges. Capturing the key physics associated with the function of the flight system has been challenging due to the many different domains that are applicable. Key interfaces and operational concepts have led to complex negotiations because of the large number of organizations that integrate with the instrument mechanical system. Additionally, the verification and validation concerns associated with the mechanical system have had required far-reaching involvement from both the flight system and other subsystems. The SMAP instrument mechanical systems engineering issues and their solutions are described in this paper.

  14. Physics and instrumentation of ultrasound.

    PubMed

    Lawrence, John P

    2007-08-01

    A thorough understanding of the physics of ultrasound waves and the instrumentation will provide the user with a better understanding of the capabilities and limitations of ultrasound equipment. The ultrasound machine combines two technologies: image production (M-mode and 2-dimensional imaging) with Doppler assessment (continuous and pulse wave as well as color-flow mapping). These distinct technologies have been combined to provide the examiner with the ability to make accurate and comprehensive diagnoses and guide therapeutic intervention.

  15. High resolution tomographic instrument development

    SciTech Connect

    Not Available

    1992-08-01

    Our recent work has concentrated on the development of high-resolution PET instrumentation reflecting in part the growing importance of PET in nuclear medicine imaging. We have developed a number of positron imaging instruments and have the distinction that every instrument has been placed in operation and has had an extensive history of application for basic research and clinical study. The present program is a logical continuation of these earlier successes. PCR-I, a single ring positron tomograph was the first demonstration of analog coding using BGO. It employed 4 mm detectors and is currently being used for a wide range of biological studies. These are of immense importance in guiding the direction for future instruments. In particular, PCR-II, a volume sensitive positron tomograph with 3 mm spatial resolution has benefited greatly from the studies using PCR-I. PCR-II is currently in the final stages of assembly and testing and will shortly be placed in operation for imaging phantoms, animals and ultimately humans. Perhaps the most important finding resulting from our previous study is that resolution and sensitivity must be carefully balanced to achieve a practical high resolution system. PCR-II has been designed to have the detection characteristics required to achieve 3 mm resolution in human brain under practical imaging situations. The development of algorithms by the group headed by Dr. Chesler is based on a long history of prior study including his joint work with Drs. Pelc and Reiderer and Stearns. This body of expertise will be applied to the processing of data from PCR-II when it becomes operational.

  16. High resolution tomographic instrument development

    SciTech Connect

    Not Available

    1992-01-01

    Our recent work has concentrated on the development of high-resolution PET instrumentation reflecting in part the growing importance of PET in nuclear medicine imaging. We have developed a number of positron imaging instruments and have the distinction that every instrument has been placed in operation and has had an extensive history of application for basic research and clinical study. The present program is a logical continuation of these earlier successes. PCR-I, a single ring positron tomograph was the first demonstration of analog coding using BGO. It employed 4 mm detectors and is currently being used for a wide range of biological studies. These are of immense importance in guiding the direction for future instruments. In particular, PCR-II, a volume sensitive positron tomograph with 3 mm spatial resolution has benefited greatly from the studies using PCR-I. PCR-II is currently in the final stages of assembly and testing and will shortly be placed in operation for imaging phantoms, animals and ultimately humans. Perhaps the most important finding resulting from our previous study is that resolution and sensitivity must be carefully balanced to achieve a practical high resolution system. PCR-II has been designed to have the detection characteristics required to achieve 3 mm resolution in human brain under practical imaging situations. The development of algorithms by the group headed by Dr. Chesler is based on a long history of prior study including his joint work with Drs. Pelc and Reiderer and Stearns. This body of expertise will be applied to the processing of data from PCR-II when it becomes operational.

  17. [Instrumental diagnosis in shoulder instability].

    PubMed

    Lalla, E; Rosa, D; Grillo, G; Belfiore, G

    1989-01-01

    The authors call attention to the pathology caused by glenohumeral instability and, in particular, to painful shoulders in athletes which so often cause problems in diagnosis. An instrumental protocol for diagnosis is suggested, based on several specific radiographic views, Ct scan and arthro-Ct scan, with double contrast medium, the latter having the task of determining lesion which would not otherwise be able to be studied.

  18. Nuclear instrumentation cable end seal

    DOEpatents

    Cannon, Collins P.; Brown, Donald P.

    1979-01-01

    An improved coaxial end seal for hermetically sealed nuclear instrumentation cable exhibiting an improved breakdown pulse noise characteristic under high voltage, high temperature conditions. A tubular insulator body has metallized interior and exterior surface portions which are braze sealed to a center conductor and an outer conductive sheath. The end surface of the insulator body which is directed toward the coaxial cable to which it is sealed has a recessed surface portion within which the braze seal material terminates.

  19. High resolution tomographic instrument development

    NASA Astrophysics Data System (ADS)

    Our recent work has concentrated on the development of high-resolution PET instrumentation reflecting in part the growing importance of PET in nuclear medicine imaging. We have developed a number of positron imaging instruments and have the distinction that every instrument has been placed in operation and has had an extensive history of application for basic research and clinical study. The present program is a logical continuation of these earlier successes. PCR-I, a single ring positron tomograph was the first demonstration of analog coding using BGO. It employed 4 mm detectors and is currently being used for a wide range of biological studies. These are of immense importance in guiding the direction for future instruments. In particular, PCR-II, a volume sensitive positron tomograph with 3 mm spatial resolution has benefitted greatly from the studies using PCR-I. PCR-II is currently in the final stages of assembly and testing and will shortly be placed in operation for imaging phantoms, animals and ultimately humans. Perhaps the most important finding resulting from our previous study is that resolution and sensitivity must be carefully balanced to achieve a practical high resolution system. PCR-II has been designed to have the detection characteristics required to achieve 3 mm resolution in human brain under practical imaging situations. The development of algorithms by the group headed by Dr. Chesler is based on a long history of prior study including his joint work with Drs. Pelc and Reiderer and Stearns. This body of expertise will be applied to the processing of data from PCR-II when it becomes operational.

  20. Spatial Displays and Spatial Instruments

    NASA Technical Reports Server (NTRS)

    Ellis, Stephen R. (Editor); Kaiser, Mary K. (Editor); Grunwald, Arthur J. (Editor)

    1989-01-01

    The conference proceedings topics are divided into two main areas: (1) issues of spatial and picture perception raised by graphical electronic displays of spatial information; and (2) design questions raised by the practical experience of designers actually defining new spatial instruments for use in new aircraft and spacecraft. Each topic is considered from both a theoretical and an applied direction. Emphasis is placed on discussion of phenomena and determination of design principles.

  1. Instrumentation in antimicrobial susceptibility testing.

    PubMed

    Felmingham, D; Brown, D F

    2001-07-01

    Studies in the 1960s demonstrated the problems of variability in susceptibility testing methods, especially those affecting the performance of disc diffusion procedures. These studies made apparent the need for standardization and resulted in more clearly defined performance limits for growth medium, incubation conditions, inoculum concentration, disc content for diffusion methods, the setting of interpretative MIC breakpoints and the establishment of quality control parameters. More recently, there has been a growing interest in the use of instrumentation for reading disc diffusion tests and the endpoints of agar or broth dilution MIC determinations. Instrumentation ranges in complexity from the simple optical reading of zones of inhibition or growth endpoints, requiring operator interpretation, to more sophisticated devices for reading, recording and 'expert system' analysis of results with interfacing of instruments to laboratory information management systems. Some of the more developed systems are fully automated and can also identify the organisms tested. The pressure to reduce labour costs and provide results earlier favours the use of more automated systems whilst the requirement for resistance surveillance provides impetus for the use of systems that provide quantitative results and electronic data handling.

  2. Multimodality Instrument for Tissue Characterization

    NASA Technical Reports Server (NTRS)

    Mah, Robert W. (Inventor); Andrews, Russell J. (Inventor)

    2000-01-01

    A system with multimodality instrument for tissue identification includes a computer-controlled motor driven heuristic probe with a multisensory tip is discussed. For neurosurgical applications, the instrument is mounted on a stereotactic frame for the probe to penetrate the brain in a precisely controlled fashion. The resistance of the brain tissue being penetrated is continually monitored by a miniaturized strain gauge attached to the probe tip. Other modality sensors may be mounted near the probe tip to provide real-time tissue characterizations and the ability to detect the proximity of blood vessels, thus eliminating errors normally associated with registration of pre-operative scans, tissue swelling, elastic tissue deformation, human judgement, etc., and rendering surgical procedures safer, more accurate, and efficient. A neural network, program adaptively learns the information on resistance and other characteristic features of normal brain tissue during the surgery and provides near real-time modeling. A fuzzy logic interface to the neural network program incorporates expert medical knowledge in the learning process. Identification of abnormal brain tissue is determined by the detection of change and comparison with previously learned models of abnormal brain tissues. The operation of the instrument is controlled through a user friendly graphical interface. Patient data is presented in a 3D stereographics display. Acoustic feedback of selected information may optionally be provided. Upon detection of the close proximity to blood vessels or abnormal brain tissue, the computer-controlled motor immediately stops probe penetration.

  3. The Polar Plasma Wave Instrument

    NASA Technical Reports Server (NTRS)

    Gurnett, D. A.; Persoon, A. M.; Randall, R. F.; Odem, D. L.; Remington, S. L.; Averkamp, T. F.; Debower, M. M.; Hospodarsky, G. B.; Huff, R. L.; Kirchner, D. L.

    1995-01-01

    The Plasma Wave Instrument on the Polar spacecraft is designed to provide measurements of plasma waves in the Earth's polar regions over the frequency range from 0.1 Hz to 800 kHz. Three orthogonal electric dipole antennas are used to detect electric fields, two in the spin plane and one aligned along the spacecraft spin axis. A magnetic loop antenna and a triaxial magnetic search coil antenna are used to detect magnetic fields. Signals from these antennas are processed by five receiver systems: a wideband receiver, a high-frequency waveform receiver, a low-frequency waveform receiver, two multichannel analyzers; and a pair of sweep frequency receivers. Compared to previous plasma wave instruments, the Polar plasma wave instrument has several new capabilities. These include (1) an expanded frequency range to improve coverage of both low- and high-frequency wave phenomena, (2) the ability to simultaneously capture signals from six orthogonal electric and magnetic field sensors, and (3) a digital wideband receiver with up to 8-bit resolution and sample rates as high as 249k samples s(exp -1).

  4. Geotechnical instrumentation for repository shafts

    SciTech Connect

    Lentell, R.L.; Byrne, J.

    1993-09-01

    The US Congress passed the Nuclear Waste Policy Act in 1980, which required that three distinctly different geologic media be investigated as potential candidate sites for the permanent disposal of high-level nuclear waste. The three media that were selected for study were basalt (WA), salt (TX, LA, MS, UT), and tuff (NV). Preliminary Exploratory Shaft Facilities (ESF) designs were prepared for seven candidate salt sites, including bedded and domal salt environments. A bedded-salt site was selected in Deaf Smith County, TX for detailed site characterization studies and ESF Final Design. Although Congress terminated the Salt Repository Program in 1988, Final Design for the Deaf Smith ESF was completed, and much of the design rationale can be applied to subsequent deep repository shafts. This paper presents the rationale for the geotechnical instrumentation that was designed for construction and operational performance monitoring of the deep shafts of the in-situ test facility. The instrumentation design described herein can be used as a general framework in designing subsequent instrumentation programs for future high-level nuclear waste repository shafts.

  5. Aeronautic Instruments. Section VI : Aerial Navigation and Navigating Instruments

    NASA Technical Reports Server (NTRS)

    Eaton, H N

    1923-01-01

    This report outlines briefly the methods of aerial navigation which have been developed during the past few years, with a description of the different instruments used. Dead reckoning, the most universal method of aerial navigation, is first discussed. Then follows an outline of the principles of navigation by astronomical observation; a discussion of the practical use of natural horizons, such as sea, land, and cloud, in making extant observations; the use of artificial horizons, including the bubble, pendulum, and gyroscopic types. A description is given of the recent development of the radio direction finder and its application to navigation.

  6. Regioselective synthesis and biological studies of novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives as potential antiproliferative agents.

    PubMed

    Ananda, Hanumappa; Sharath Kumar, Kothanahally S; Nishana, Mayilaadumveettil; Hegde, Mahesh; Srivastava, Mrinal; Byregowda, Raghava; Choudhary, Bibha; Raghavan, Sathees C; Rangappa, Kanchugarakoppal S

    2017-02-01

    Pyrazole moiety represents an important category of heterocyclic compound in pharmaceutical and medicinal chemistry. The novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives were synthesized with complementary regioselectivity. The chemical structures were confirmed by IR, (1)H NMR, (13)C NMR, and mass spectral analysis. The chemical entities were screened in various cancer cell lines to assess their cell viability activity. Results showed that the compound 3-(1-(4-bromophenyl)-5-phenyl-1H-pyrazol-3-yl) pyridine (5d) possessed maximum cytotoxic effect against breast cancer and leukemic cells. The cytotoxicity was confirmed by live-dead cell assay and cell cycle analysis. Mitochondrial membrane potential, Annexin V-FITC staining, DNA fragmentation, Hoechst staining, and western blot assays revealed the ability of compound 5d to induce cell death by activating apoptosis in cancer cells. Thus, the present study demonstrates that compound 5d could be an attractive chemical entity for the development of small molecule inhibitors for treatment of leukemia and breast cancer.

  7. The Dark Energy Spectroscopic Instrument (DESI) instrument mechanism control systems

    NASA Astrophysics Data System (ADS)

    Coker, Carl T.; Pappalardo, Daniel; Pogge, Richard; Martini, Paul; Derwent, Mark; O'Brien, Thomas P.; Honscheid, Klaus

    2016-08-01

    The Dark Energy Spectroscopic Instrument (DESI) is under construction to measure the expansion history of the Universe using the Baryon Acoustic Oscillation technique. The spectra of 40 million galaxies over 14,000 sq deg will be measured during the life of the experiment. A new prime focus corrector for the KPNO Mayall telescope will deliver light to 5,000 fiber optic positioners. The fibers in turn feed ten broad-band spectrographs. We present the design details of the instrument mechanism control systems for the spectrographs. Each spectrograph has a stand-alone mechanism control box that operates the unit's four remotely-operated mechanisms (two shutters and two Hartmannn doors), and provides a suite of temperature and humidity sensors. Each control box is highly modular, and is operated by a dedicated on-board Linux computer to provide all of the control and monitoring functions. We describe our solution for integrating a number of network-connected devices within each unit spectrograph, and describe the basic software architecture.

  8. Regional Instrumentation Facilities Established by NSF.

    ERIC Educational Resources Information Center

    Analytical Chemistry, 1979

    1979-01-01

    This article describes the six regional instrumentation facilities established by the National Science Foundation. These centers make available to scientists state-of-the-art instrumentation such as: gas chromatographs; lasers; NMR spectrometers; X-rays; and others. (CS)

  9. Use of Electrical and Electronic Instruments

    ERIC Educational Resources Information Center

    Mosbacher, C. J.; Thomas, E. J.

    1977-01-01

    Presents results of a trend survey of the present and planned use of electrical and electronic instruments. Microprocessors were found to have the highest predicted growth rate of all instruments included in the survey. (SL)

  10. Pointing compensation system for spacecraft instruments

    NASA Technical Reports Server (NTRS)

    Plescia, Carl T. (Inventor); Gamble, Donald W. (Inventor)

    1987-01-01

    A closed loop system reduces pointing errors in one or more spacecraft instruments. Associated with each instrument is a electronics package (3) for commanding motion in that instrument and a pointing control system (5) for imparting motion in that instrument in response to a command (4) from the commanding package (3). Spacecraft motion compensation logic (25) compensates for instrument pointing errors caused by instrument-motion-induced spacecraft motion. Any finite number of instruments can be so compensated, by providing each pointing control system (5) and each commanding package (3), for the instruments desired to be compensated, with a link to the spacecraft motion compensation logic (25). The spacecraft motion compensation logic (25) is an electronic manifestation of the algebraic negative of a model of the dynamics of motion of the spacecraft. An example of a suitable model, and computer-simulated results, are presented.

  11. Instrumentation for Sensitive Gas Measurements

    NASA Technical Reports Server (NTRS)

    OKeefe, Anthony

    2005-01-01

    An improved instrument for optical absorption spectroscopy utilizes off-axis paths in an optical cavity in order to increase detection sensitivity while suppressing resonance effects. The instrument is well suited for use in either cavity ring-down spectroscopy (CRDS) [in which one pulses an incident light beam and measures the rate of decay of light in the cavity] or integrated cavity output spectroscopy (ICOS) [in which one uses a continuous-wave incident light beam and measures the power of light in the cavity as a function of wavelength]. Typically, in optical absorption spectroscopy, one seeks to measure absorption of a beam of light in a substance (usually a gas or liquid) in a sample cell. In CRDS or ICOS, the sample cell is placed in (or consists of) an optical cavity, so that one can utilize multiple reflections of the beam to increase the effective optical path length through the absorbing substance and thereby increase the sensitivity for measuring absorption. If an absorbing substance is not present in the optical cavity, one can utilize the multiple passes of the light beam to increase the sensitivity for measuring absorption and scattering by components of the optical cavity itself. It is desirable to suppress the effects of resonances in the cavity in order to make the spectral response of the cavity itself as nearly constant as possible over the entire wavelength range of interest. In the present instrument, the desired flattening of the spectral response is accomplished by utilizing an off-axis beam geometry to effectively decrease the frequency interval between longitudinal electromagnetic modes of the cavity, such that the resulting transmission spectrum of the cavity is nearly continuous: in other words, the cavity becomes a broad-band optical device.

  12. Multimodality instrument for tissue characterization

    NASA Technical Reports Server (NTRS)

    Mah, Robert W. (Inventor); Andrews, Russell J. (Inventor)

    2004-01-01

    A system with multimodality instrument for tissue identification includes a computer-controlled motor driven heuristic probe with a multisensory tip. For neurosurgical applications, the instrument is mounted on a stereotactic frame for the probe to penetrate the brain in a precisely controlled fashion. The resistance of the brain tissue being penetrated is continually monitored by a miniaturized strain gauge attached to the probe tip. Other modality sensors may be mounted near the probe tip to provide real-time tissue characterizations and the ability to detect the proximity of blood vessels, thus eliminating errors normally associated with registration of pre-operative scans, tissue swelling, elastic tissue deformation, human judgement, etc., and rendering surgical procedures safer, more accurate, and efficient. A neural network program adaptively learns the information on resistance and other characteristic features of normal brain tissue during the surgery and provides near real-time modeling. A fuzzy logic interface to the neural network program incorporates expert medical knowledge in the learning process. Identification of abnormal brain tissue is determined by the detection of change and comparison with previously learned models of abnormal brain tissues. The operation of the instrument is controlled through a user friendly graphical interface. Patient data is presented in a 3D stereographics display. Acoustic feedback of selected information may optionally be provided. Upon detection of the close proximity to blood vessels or abnormal brain tissue, the computer-controlled motor immediately stops probe penetration. The use of this system will make surgical procedures safer, more accurate, and more efficient. Other applications of this system include the detection, prognosis and treatment of breast cancer, prostate cancer, spinal diseases, and use in general exploratory surgery.

  13. Tevatron instrumentation: boosting collider performance

    SciTech Connect

    Shiltsev, Vladimir; Jansson, Andreas; Moore, Ronald; /Fermilab

    2006-05-01

    The Tevatron in Collider Run II (2001-present) is operating with six times more bunches, many times higher beam intensities and luminosities than in Run I (1992-1995). Beam diagnostics were crucial for the machine start-up and the never-ending luminosity upgrade campaign. We present the overall picture of the Tevatron diagnostics development for Run II, outline machine needs for new instrumentation, present several notable examples that led to Tevatron performance improvements, and discuss the lessons for the next big machines--LHC and ILC.

  14. Instrument Deployment for Mars Rovers

    NASA Technical Reports Server (NTRS)

    Pedersen, Liam; Bualat, Maria; Kunz, C.; Lee, Susan; Sargent, Randy; Washington, Rich; Wright, Anne; Clancy, Daniel (Technical Monitor)

    2002-01-01

    Future Mars rovers, such as the planned 2009 MSL rover, require sufficient autonomy to robustly approach rock targets and place an instrument in contact with them. It took the 1997 Sojourner Mars rover between 3 and 5 communications cycles to accomplish this. This paper describes the technologies being developed and integrated onto the NASA Ames K9 prototype Mars rover to both accomplish this in one cycle, and to extend the complexity and duration of operations that a Mars rover can accomplish without intervention from mission control.

  15. Solwind instrument destroyed in test

    NASA Astrophysics Data System (ADS)

    The U.S. Air Force's destruction of one of its own satellites last month ended what had been the longest continuous stream of data from an instrument observing the sun's corona. Satellite P78-1 served as the target in a test of antisatellite (ASAT) weaponry on September 13, 1985. The satellite carried Solwind, a white light coronagraph that observed the solar corona at distances of 3-10 solar radii, according to Robert M. MacQueen, director of the High Altitude Observatory at the National Center for Atmospheric Research (NCAR) in Boulder, Colo.

  16. Small satellite radiation budget instrumentation

    SciTech Connect

    Weber, P.G.

    1992-01-01

    A major diagnostic in understanding the response of the Earth's climate to natural or anthropogenic changes is the radiative balance at the top of the atmosphere. Two classes of measurements may be undertaken: (1) a monitoring of the radiation balance over decade-long long time-scales, and (2) measurements designed to provide a sufficiently complete data set to validate or improve models. This paper discusses some of the important ingredients in obtaining such data, and presents a description of some candidate instrumentation for use on a small satellite. 23 refs.

  17. Small satellite radiation budget instrumentation

    SciTech Connect

    Weber, P.G.

    1992-05-01

    A major diagnostic in understanding the response of the Earth`s climate to natural or anthropogenic changes is the radiative balance at the top of the atmosphere. Two classes of measurements may be undertaken: (1) a monitoring of the radiation balance over decade-long long time-scales, and (2) measurements designed to provide a sufficiently complete data set to validate or improve models. This paper discusses some of the important ingredients in obtaining such data, and presents a description of some candidate instrumentation for use on a small satellite. 23 refs.

  18. The AsteroidFinder Instrument

    NASA Astrophysics Data System (ADS)

    Michaelis, Harald; Mottola, Stefano; Kuehrt, Ekkehard; Hoffmann, Harald; Behnke, Thomas; Messina, Gabriele; Tschentscher, Matthias; Scheibe, Karsten; Solbrig, Michael; Mosebach, Herbert; Hartl, Michael; Lenfert, Kay

    The DLR Institute of Planetary Exploration has proposed a novel design for a space instrument accommodated on a small satellite bus (SSB) that is dedicated to the detection of inner earth objects (IEOs) from a low earth orbit (LEO). The instrument requires high sensitivity to detect asteroids with a limiting magnitude of equal or larger than 18.5m (V-Band) and astrometric accuracy of 1 arcsec (1). This requires a telescope aperture greater than 400cm2, high image stability, detector with high quantum efficiency (peak∼90). The instrument design is based on a novel focal plane consisting of four Electron-Multiplying CCDs (EMCCD). These detectors operate at a high frame rate of nominally 5fps and very low effective readout noise (¡2e rms), in order to compensate the spacecraft's pointing jitter. The telescope optics is based on an off-axis anastigmatic design (TMA). A reflective Schmidt-type corrector plate enables a corrected 22 field of view to be achieved by the fast F/3.4 telescope with near diffraction-limited performance. The absence of center obscurations or spiders in combination with an accessible intermediate field plane and exit pupil allow for efficient stray light mitigation. To accommodate the passive thermal stabilization scheme and the necessary structural stability, HB-Cesic R was selected as material for the telescope structure and mirrors. This new composite ceramic material is highly promising for space telescope applications. The electronics design comprises high speed signal and data processing chains for on-board acquisition, filtering, accumulation and compression of the CCD data. One of the most important tasks of the on-board processing software is to implement the image stabilization function. For this purpose the images are oversampled, guide stars are automatically identified and tracked, and the individual short-exposure images are shifted and co-added with sub-pixel accuracy. During this process, spurious events as cosmic ray hits or

  19. Simulations of the WUVS instrument

    NASA Astrophysics Data System (ADS)

    Marcos-Arenal, Pablo; Gómez de Castro, Ana I.; Perea Abarca, Belén.; Sachkov, Mikhail

    2016-07-01

    The performance of the WUVS (WSO-UV Spectrographs) can be evaluated through simulations of the expected observations. Here we discuss the implementation details and the noise models applied in the simulation software tool developed to carry on these simulations. The WUVS Simulator has been implemented as a further development of the PLATO Simulator, adapting it to the WUVS specific characteristics. It is designed to generate synthetic time-series of images by including models of all important noise sources. The expected overall noise budget of the output images is evaluated as a function of different sets of input parameters describing the instrument properties.

  20. Condensation Particle Counter Instrument Handbook

    SciTech Connect

    Kuang, C.

    2016-02-01

    The Model 3772 CPC is a compact, rugged, and full-featured instrument that detects airborne particles down to 10 nm in diameter, at an aerosol flow rate of 1.0 lpm, over a concentration range from 0 to 1x104 #/cc. This CPC is ideally suited for applications without high concentration measurements, such as basic aerosol research, filter and air-cleaner testing, particle counter calibrations, environmental monitoring, mobile aerosol studies, particle shedding and component testing, and atmospheric and climate studies.

  1. Compact Instruments Measure Heat Potential

    NASA Technical Reports Server (NTRS)

    2009-01-01

    Based in Huntsville, Alabama, AZ Technology Inc. is a woman- and veteran-owned business that offers expertise in electromechanical-optical design and advanced coatings. AZ Technology has received eight Small Business Innovation Research (SBIR) contracts with Marshall Space Flight Center for the development of spectral reflectometers and the measurement of surface thermal properties. The company uses a variety of measurement services and instruments, including the Spectrafire, a portable spectral emissometer it used to assist General Electric with the design of its award-winning Giraffe Warmer for neonatal intensive care units.

  2. Mariner Jupiter/Saturn infrared instrument study

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The Mariner Jupiter/Saturn infrared instrumentation conceptual design study was conducted to determine the physical and operational characteristics of the instruments needed to satisfy the experiment science requirements. The design of the instruments is based on using as many proven concepts as possible. Many design features are taken from current developments such as the Mariner, Pioneer 10, Viking Orbiter radiometers, and Nimbus D spectrometer. Calibration techniques and error analysis for the instrument system are discussed.

  3. Space Infrared Telescope Facility science instruments overview

    NASA Technical Reports Server (NTRS)

    Bothwell, Mary

    1991-01-01

    The Space Infrared Telescope Facility (SIRTF) will contain three cryogenically cooled infrared instruments: the Infrared Array Camera (IRAC), the Infrared Spectrograph (IRS), and the Multiband Infrared Photometer for SIRTF (MIPS). These instruments are sensitive to infrared radiation in the 1.8-1,200 micrometer range. This paper will discuss the three instruments' functional requirements and their accommodation in the SIRTF telescope system.

  4. Chemical Instrumentation for the Visually Handicapped.

    ERIC Educational Resources Information Center

    Anderson, James L.

    1982-01-01

    Describes a simple, relatively inexpensive, and easily implemented approach for introducing visually handicapped students to chemical instrumentation via experiments on operational amplifiers as examples of some of the electronic building blocks of chemical instrumentation. The approach is applicable to other chemical instruments having electrical…

  5. Adult Perspectives of Learning Musical Instruments

    ERIC Educational Resources Information Center

    Roulston, Kathryn; Jutras, Peter; Kim, Seon Joo

    2015-01-01

    This article reports findings from a qualitative study of adults' perceptions and experiences of learning musical instruments. Conducted in the south-east United States, 15 adults who were learning instruments were recruited via community music groups and private instrumental teachers. Analysis of transcripts of semi-structured interviews…

  6. Industrial Instrument Mechanic. Occupational Analyses Series.

    ERIC Educational Resources Information Center

    Dean, Ann; Zagorac, Mike; Bumbaka, Nick

    This analysis covers tasks performed by an industrial instrument mechanic, an occupational title some provinces and territories of Canada have also identified as industrial instrumentation and instrument mechanic. A guide to analysis discusses development, structure, and validation method; scope of the occupation; trends; and safety. To facilitate…

  7. 14 CFR 27.1381 - Instrument lights.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Instrument lights. 27.1381 Section 27.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1381 Instrument lights. The instrument...

  8. 14 CFR 29.1381 - Instrument lights.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Instrument lights. 29.1381 Section 29.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1381 Instrument lights. The instrument...

  9. 14 CFR 29.1381 - Instrument lights.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Instrument lights. 29.1381 Section 29.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1381 Instrument lights. The instrument...

  10. 14 CFR 27.1381 - Instrument lights.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Instrument lights. 27.1381 Section 27.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1381 Instrument lights. The instrument...

  11. 14 CFR 27.1381 - Instrument lights.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Instrument lights. 27.1381 Section 27.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1381 Instrument lights. The instrument...

  12. 14 CFR 29.1381 - Instrument lights.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Instrument lights. 29.1381 Section 29.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1381 Instrument lights. The instrument...

  13. 14 CFR 27.1381 - Instrument lights.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Instrument lights. 27.1381 Section 27.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1381 Instrument lights. The instrument...

  14. 14 CFR 29.1381 - Instrument lights.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Instrument lights. 29.1381 Section 29.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1381 Instrument lights. The instrument...

  15. 14 CFR 29.1381 - Instrument lights.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Instrument lights. 29.1381 Section 29.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Equipment Lights § 29.1381 Instrument lights. The instrument...

  16. 14 CFR 27.1381 - Instrument lights.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Instrument lights. 27.1381 Section 27.1381 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Equipment Lights § 27.1381 Instrument lights. The instrument...

  17. Earth Viewing Applications Laboratory (EVAL). Instrument catalog

    NASA Technical Reports Server (NTRS)

    1976-01-01

    There were 87 instruments described that are used in earth observation, with an additional 51 instruments containing references to programs and their major functions. These instruments were selected from such sources as: (1) earth observation flight program, (2) operational satellite improvement programs, (3) advanced application flight experiment program, (4) shuttle experiment definition program, and (5) earth observation aircraft program.

  18. ICFA Instrumentation Bulletin, Volume 13, Fall 1996

    SciTech Connect

    1996-12-01

    The publication of the ICFA Instrumentation Bulletin is an activity of the Panel on Future Innovation and Development of ICFA (International Committee for Future Accelerators). The Bulletin reports on research and progress in the field of instrumentation with emphasis on application in the field of high-energy physics. It encourages issues of generic instrumentation.

  19. Are Musical Instrument Gender Associations Changing?

    ERIC Educational Resources Information Center

    Abeles, Hal

    2009-01-01

    The researcher sought to examine gender associations across three decades to determine if changes in the sex stereotyping of musical instruments has occurred. First, the study examined the paired comparison gender-instrument rankings of 180 college students. The results confirmed a reduction of instrument gender associations reported in the 1990s.…

  20. Experimental prototype instruments for nondestructive testing

    SciTech Connect

    Smolyakova, L.E.

    1987-10-01

    Results are given of state acceptance tests on experimental prototype nondestructive testing instruments along with their technical specifications and advantages over the better Soviet and foreign counterparts. The instruments include the UF-10P ultrasonic hydrostatic testing instrument, the PRIZ-12 piezoelectric transducer, and the RTVK-2K and LEB-1K radioisotope thickness gages.

  1. 47 CFR 73.688 - Indicating instruments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Indicating instruments. 73.688 Section 73.688... Television Broadcast Stations § 73.688 Indicating instruments. (a) Each TV broadcast station shall be equipped with indicating instruments which conform with the specifications described in § 73.1215...

  2. 31 CFR 596.307 - Monetary instruments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Monetary instruments. 596.307 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS REGULATIONS General Definitions § 596.307 Monetary instruments. The term monetary instruments shall have the...

  3. 31 CFR 596.307 - Monetary instruments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Monetary instruments. 596.307 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS REGULATIONS General Definitions § 596.307 Monetary instruments. The term monetary instruments shall have the...

  4. ICFA Instrumentation Bulletin, Volume 14, Spring 1997

    SciTech Connect

    1997-07-01

    The publication of the ICFA Instrumentation Bulletin is an activity of the Panel on Future Innovation and Development of ICFA (International Committee for Future Accelerators). The Bulletin reports on research and progress in the field of instrumentation with emphasis on application in the field of high-energy physics. It encourages issues of generic instrumentation.

  5. 47 CFR 73.58 - Indicating instruments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Indicating instruments. 73.58 Section 73.58... Broadcast Stations § 73.58 Indicating instruments. (a) Each AM broadcast station must be equipped with indicating instruments which conform with the specifications described in § 73.1215 for determining power...

  6. 47 CFR 73.688 - Indicating instruments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Indicating instruments. 73.688 Section 73.688... Television Broadcast Stations § 73.688 Indicating instruments. (a) Each TV broadcast station shall be equipped with indicating instruments which conform with the specifications described in § 73.1215...

  7. 14 CFR 33.29 - Instrument connection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Instrument connection. 33.29 Section 33.29... STANDARDS: AIRCRAFT ENGINES Design and Construction; General § 33.29 Instrument connection. (a) Unless it is constructed to prevent its connection to an incorrect instrument, each connection provided for...

  8. Defocus in cathode lens instruments.

    PubMed

    Tromp, R M; Altman, M S

    2017-02-24

    Accurately measuring defocus in cathode lens instruments (Low Energy Electron Microscopy - LEEM, and Photo Electron Emission Microscopy - PEEM) is a pre-requisite for quantitative image analysis using Fourier Optics (FO) or Contrast Transfer Function (CTF) image simulations. In particular, one must establish a quantitative relation between lens excitation and image defocus. One way to accomplish this is the Real-Space Microspot LEED method, making use of the accurately known angles of diffracted electron beams, and the defocus-dependent shifts of their corresponding real-space images. However, this only works if a sufficiently large number of diffracted beams is available for the sample under investigation. An alternative is to shift the sample along the optical axis by a known distance, and measure the change in objective lens excitation required to re-focus the image. We analytically derive the relation between sample shift and defocus, and apply our results to the measurement and analysis of achromats in an aberration-corrected LEEM instrument.

  9. The TROPOspheric Monitoring Instrument (TROPOMI)

    NASA Astrophysics Data System (ADS)

    Veefkind, Pepijn; Kleipool, Quintus; Aben, Ilse; Levelt, Pieternel

    2015-04-01

    The Copernicus Sentinel 5 Precursor (S5P), scheduled for launch in 2016, is the first of the sentinels dedicated to monitoring of the atmospheric composition. The main application areas of the mission are air quality, climate and the ozone layer. The single payload of the S5P mission is TROPOspheric Monitoring Instrument (TROPOMI). TROPOMI is a nadir viewing shortwave spectrometer that will measure in the UV-visible wavelength range (270-500 nm), the near infrared (710-770 nm) and the shortwave infrared (2314-2382 nm). TROPOMI will have an unprecedented spatial resolution of about 7x7 km2 at nadir. The spatial resolution is combined with a wide swath to allow for daily global coverage. The high spatial resolution serves two goals: (1) emissions sources can be detected with more accuracy and (2) the number of cloud-free ground pixels will increase substantially. The TROPOMI/S5P geophysical (Level 2) data products include nitrogen dioxide, carbon monoxide, ozone (total column, tropospheric column & profile), methane, sulphur dioxide, formaldehyde and aerosol and cloud parameters. In this contribution we will present the TROPOMI instrument performance and the new science opportunities that it will enable.

  10. BICEP2 III: Instrumental systematics

    SciTech Connect

    Ade, P. A. R.

    2015-11-23

    In a companion paper, we have reported a >5σ detection of degree scale B-mode polarization at 150 GHz by the Bicep2 experiment. Here we provide a detailed study of potential instrumental systematic contamination to that measurement. We focus extensively on spurious polarization that can potentially arise from beam imperfections. We present a heuristic classification of beam imperfections according to their symmetries and uniformities, and discuss how resulting contamination adds or cancels in maps that combine observations made at multiple orientations of the telescope about its boresight axis. We introduce a technique, which we call "deprojection," for filtering the leading order beam-induced contamination from time-ordered data, and show that it reduces power in Bicep2's actual and null-test BB spectra consistent with predictions using high signal-to-noise beam shape measurements. We detail the simulation pipeline that we use to directly simulate instrumental systematics and the calibration data used as input to that pipeline. Finally, we present the constraints on BB contamination from individual sources of potential systematics. We find that systematics contribute BB power that is a factor of ~10× below Bicep2's three-year statistical uncertainty, and negligible compared to the observed BB signal. Lastly, the contribution to the best-fit tensor/scalar ratio is at a level equivalent to r = (3–6) × 10–3.

  11. BICEP2 III: Instrumental systematics

    DOE PAGES

    Ade, P. A. R.

    2015-11-23

    In a companion paper, we have reported a >5σ detection of degree scale B-mode polarization at 150 GHz by the Bicep2 experiment. Here we provide a detailed study of potential instrumental systematic contamination to that measurement. We focus extensively on spurious polarization that can potentially arise from beam imperfections. We present a heuristic classification of beam imperfections according to their symmetries and uniformities, and discuss how resulting contamination adds or cancels in maps that combine observations made at multiple orientations of the telescope about its boresight axis. We introduce a technique, which we call "deprojection," for filtering the leading ordermore » beam-induced contamination from time-ordered data, and show that it reduces power in Bicep2's actual and null-test BB spectra consistent with predictions using high signal-to-noise beam shape measurements. We detail the simulation pipeline that we use to directly simulate instrumental systematics and the calibration data used as input to that pipeline. Finally, we present the constraints on BB contamination from individual sources of potential systematics. We find that systematics contribute BB power that is a factor of ~10× below Bicep2's three-year statistical uncertainty, and negligible compared to the observed BB signal. Lastly, the contribution to the best-fit tensor/scalar ratio is at a level equivalent to r = (3–6) × 10–3.« less

  12. Method for improving instrument response

    DOEpatents

    Hahn, David W.; Hencken, Kenneth R.; Johnsen, Howard A.; Flower, William L.

    2000-01-01

    This invention pertains generally to a method for improving the accuracy of particle analysis under conditions of discrete particle loading and particularly to a method for improving signal-to-noise ratio and instrument response in laser spark spectroscopic analysis of particulate emissions. Under conditions of low particle density loading (particles/m.sup.3) resulting from low overall metal concentrations and/or large particle size uniform sampling can not be guaranteed. The present invention discloses a technique for separating laser sparks that arise from sample particles from those that do not; that is, a process for systematically "gating" the instrument response arising from "sampled" particles from those responses which do not, is dislosed as a solution to his problem. The disclosed approach is based on random sampling combined with a conditional analysis of each pulse. A threshold value is determined for the ratio of the intensity of a spectral line for a given element to a baseline region. If the threshold value is exceeded, the pulse is classified as a "hit" and that data is collected and an average spectrum is generated from an arithmetic average of "hits". The true metal concentration is determined from the averaged spectrum.

  13. Instrumenting the Intelligence Analysis Process

    SciTech Connect

    Hampson, Ernest; Cowley, Paula J.

    2005-05-02

    The Advanced Research and Development Activity initiated the Novel Intelligence from Massive Data (NIMD) program to develop advanced analytic technologies and methodologies. In order to support this objective, researchers and developers need to understand what analysts do and how they do it. In the past, this knowledge generally was acquired through subjective feedback from analysts. NIMD established the innovative Glass Box Analysis (GBA) Project to instrument a live intelligence mission and unobtrusively capture and objectively study the analysis process. Instrumenting the analysis process requires tailor-made software hooks that grab data from a myriad of disparate application operations and feed into a complex relational database and hierarchical file store to collect, store, retrieve, and distribute analytic data in a manner that maximizes researchers’ understanding. A key to success is determining the correct data to collect and aggregate low-level data into meaningful analytic events. This paper will examine how the GBA team solved some of these challenges, continues to address others, and supports a growing user community in establishing their own GBA environments and/or studying the data generated by GBA analysts working in the Glass Box.

  14. Bicep2. III. INSTRUMENTAL SYSTEMATICS

    SciTech Connect

    Ade, P. A. R.; Aikin, R. W.; Bock, J. J.; Brevik, J. A.; Filippini, J. P.; Golwala, S. R.; Hildebrandt, S. R.; Barkats, D.; Benton, S. J.; Bischoff, C. A.; Buder, I.; Karkare, K. S.; Bullock, E.; Dowell, C. D.; Duband, L.; Fliescher, S.; Halpern, M.; Hasselfield, M.; Hilton, G. C.; Irwin, K. D.; Collaboration: Bicep2 Collaboration; and others

    2015-12-01

    In a companion paper, we have reported a >5σ detection of degree scale B-mode polarization at 150 GHz by the Bicep2 experiment. Here we provide a detailed study of potential instrumental systematic contamination to that measurement. We focus extensively on spurious polarization that can potentially arise from beam imperfections. We present a heuristic classification of beam imperfections according to their symmetries and uniformities, and discuss how resulting contamination adds or cancels in maps that combine observations made at multiple orientations of the telescope about its boresight axis. We introduce a technique, which we call “deprojection,” for filtering the leading order beam-induced contamination from time-ordered data, and show that it reduces power in Bicep2's actual and null-test BB spectra consistent with predictions using high signal-to-noise beam shape measurements. We detail the simulation pipeline that we use to directly simulate instrumental systematics and the calibration data used as input to that pipeline. Finally, we present the constraints on BB contamination from individual sources of potential systematics. We find that systematics contribute BB power that is a factor of ∼10× below Bicep2's three-year statistical uncertainty, and negligible compared to the observed BB signal. The contribution to the best-fit tensor/scalar ratio is at a level equivalent to r = (3–6) × 10{sup −3}.

  15. Instrumentation for mass spectrometry: 1997

    SciTech Connect

    McLuckey, S.A.

    1997-08-01

    All mass spectrometry experiments involve the manipulation of material, an interface with the mass spectrometer, ionization, ion manipulation/analysis, detection and data collection/reduction. Each of these elements involve instrumentation. The wide range of species now amenable to mass spectrometry and the diverse areas of physical science in which it plays a role have led to a seemingly unlimited array of instrumental combinations. However, only a limited number of mass analyzers, and their combinations, dominate. The dominant analyzers include time-of-flight, Fourier transform ion cyclotron resonance, the Paul trap, the mass filter, and the sector mass spectrometer. Why there are so few (or so many, depending upon one`s point of view) can be understood upon consideration of a set of mass analyzer figures of merit. These include mass resolution, mass accuracy, mass range, dynamic range, abundance sensitivity, precision, efficiency, speed, MS{sup n} capability, compatibility with the ionizer, cost, and size. The most appropriate form of mass spectrometry is determined by the priorities of the particular measurement placed on the various mass analyzer characteristics and the relative strengths of the analyzers in meeting the requirements. Each of the analyzer types has a unique set of figures of merit that makes it optimally suited for particular applications. This paper discusses these figures of merit, provides data illustrating recent developments for each analyzer type, and gives the figures of merit of each type of analyzer as they stand in 1997. 101 refs., 24 figs.

  16. Optical fiber instrumentation and applications

    NASA Astrophysics Data System (ADS)

    Claus, Richard O.

    1997-11-01

    Optical fiber-based sensor instrumentation has been used extensively for the measurement of physical observables including strain, temperature and chemical changes in smart materials and smart structures, and have been integrated with MEMS devices to provide multi-measurement capability along the length of a fiber link or network. This plenary paper briefly outlines recent developments in such optical fiber sensor instrumentation. Fiber optic sensors are small in size, immune to electromagnetic interference and can be easily integrated with existing optical fiber hardware and components that have been developed primarily for use in the larger telecommunications market. Such sensors can be easily multiplexed, resulting in networks that can be used for the health monitoring of large structures, or the real-time monitoring of structural parameters required for structural analysis and control. This paper briefly describes and compares three current fiber sensor configurations that use Fabry-Perot interferometry and fiber Bragg gratings (FBG) and long-period grating (LPG) elements to monitor strain, temperature and other parameters. Extensive details concerning additional related work and field test results and applications are discussed in the references.

  17. Optical fiber instrumentation and applications

    NASA Astrophysics Data System (ADS)

    Claus, Richard O.

    1997-11-01

    Optical fiber-based sensor instrumentation has been used extensively for the measurement of physical observables including strain, temperature and chemical changes in smart materials and smart structures, and have been integrated with MEMS devices to provide multi-measurement capability along the length of a fiber link or network. This plenary paper briefly outlines recent developments in such optical fiber sensor instrumentation. Fiber optic sensors are small in size, immune to electromagnetic interference and can be easily integrated with existing optical fiber hardware nd components that have been developed primarily for use in the larger telecommunications market. Such sensors can be easily multiplexed, resulting in networks that can be used for the health monitoring of large structures, or the real-time monitoring of structural parameters required for structural analysis and control. This paper briefly describes and compares three current fiber sensor configurations that use Fabry-Perot interferometry and fiber Bragg gratings and long-period grating elements to monitor strain, temperature and other parameters. Extensive details concerning additional related work and field test results and applications are discussed in the references.

  18. Program Instrumentation and Trace Analysis

    NASA Technical Reports Server (NTRS)

    Havelund, Klaus; Goldberg, Allen; Filman, Robert; Rosu, Grigore; Koga, Dennis (Technical Monitor)

    2002-01-01

    Several attempts have been made recently to apply techniques such as model checking and theorem proving to the analysis of programs. This shall be seen as a current trend to analyze real software systems instead of just their designs. This includes our own effort to develop a model checker for Java, the Java PathFinder 1, one of the very first of its kind in 1998. However, model checking cannot handle very large programs without some kind of abstraction of the program. This paper describes a complementary scalable technique to handle such large programs. Our interest is turned on the observation part of the equation: How much information can be extracted about a program from observing a single execution trace? It is our intention to develop a technology that can be applied automatically and to large full-size applications, with minimal modification to the code. We present a tool, Java PathExplorer (JPaX), for exploring execution traces of Java programs. The tool prioritizes scalability for completeness, and is directed towards detecting errors in programs, not to prove correctness. One core element in JPaX is an instrumentation package that allows to instrument Java byte code files to log various events when executed. The instrumentation is driven by a user provided script that specifies what information to log. Examples of instructions that such a script can contain are: 'report name and arguments of all called methods defined in class C, together with a timestamp'; 'report all updates to all variables'; and 'report all acquisitions and releases of locks'. In more complex instructions one can specify that certain expressions should be evaluated and even that certain code should be executed under various conditions. The instrumentation package can hence be seen as implementing Aspect Oriented Programming for Java in the sense that one can add functionality to a Java program without explicitly changing the code of the original program, but one rather writes an

  19. Instrumentation for detailed bridge-scour measurements

    USGS Publications Warehouse

    Landers, Mark N.; Mueller, David S.; Trent, Roy E.; ,

    1993-01-01

    A portable instrumentation system is being developed to obtain channel bathymetry during floods for detailed bridge-scour measurements. Portable scour measuring systems have four components: sounding instrument, horizontal positioning instrument, deployment mechanisms, and data storage device. The sounding instrument will be a digital fathometer. Horizontal position will be measured using a range-azimuth based hydrographic survey system. The deployment mechanism designed for this system is a remote-controlled boat using a small waterplane area, twin-hull design. An on-board computer and radio will monitor the vessel instrumentation, record measured data, and telemeter data to shore.

  20. Mini-Laparoscopy: Instruments and Economics.

    PubMed

    Shadduck, Phillip P; Paquentin, Eduardo Moreno; Carvalho, Gustavo L; Redan, Jay A

    2015-11-01

    Mini-laparoscopy (Mini) was pioneered more than 20 years ago, initially with instruments borrowed from other specialties and subsequently with tools designed specifically for Mini. Early adoption of Mini was inhibited though by the limitations of these first-generation instruments, especially functionality and durability. Newer generation Mini instruments have recently become available with improved effector tips, a choice of shaft diameters and lengths, better shaft insulation and electrosurgery capability, improved shaft strength and rotation, more ergonomic handles, low-friction trocar options, and improved instrument durability. Improvements are also occurring in imaging and advanced energy for Mini. The current status of mini-laparoscopy instruments and economics are presented.

  1. MEMS Actuators for Tuning Nanometer-scale Airgaps in Heterostructures and Optical Instrumentation for Glacier Ice Studies

    NASA Astrophysics Data System (ADS)

    Chan, Wing Shan

    MEMS Actuators for Tuning Nanometer-scale Airgaps in Heterostructures: We developed a new actuator microstructure to control the spacing between closely spaced surfaces. Creating and controlling nanometer gaps is of interest in areas such as plasmonics and quantum electronics. For example, energy states in quantum well heterostructures can be tuned by adjusting the physical coupling distance between wells. Unfortunately, such an application calls for active control of a nano-scale air gap between surfaces which are orders of magnitude larger, which is difficult due to stiction forces. A vertical electrostatic wedge actuator was designed to control the air gap between two closely spaced quantum wells in a collapsed cantilever structure. A six-mask fab- rication process was developed and carried out on an InGaAs/InP quantum well het- erostructure on an InP substrate. Upon actuation, the gap spacing between the surfaces was tuned over a maximum range of 55 nm from contact with an applied voltage of 60 V. Challenges in designing and fabricating the device are discussed. Optical Instrumentation for Glacier Ice Studies: We explored new optical instrumentation for glacier ice studies. Glacier ice, such as that of the Greenland and Antarctic ice sheets, is formed by the accumulation of snowfall over hundreds of thousands of years. Not all snowfalls are the same. Their isotopic compositions vary according to the planet's climate at the time, and may contain part of the past atmosphere. The physical properties and chemical content of the ice are therefore proxies of Earth's climate history. In this work, new optical methods and instrumentation based on light scattering and polarization were developed to more efficiently study glacier ice. Field deployments in Antarctica of said instrumentation and results acquired are presented.

  2. Instrumentation at the Anglo-Australian Observatory

    NASA Astrophysics Data System (ADS)

    Barden, Samuel C.

    2004-09-01

    The Anglo-Australian Observatory (AAO) has an instrumentation group for engineering, design, and fabrication that integrates tightly with an energetic group of instrument scientists1 to develop complex astronomical instruments. This instrumentation group puts ideas for innovative technical solutions generated by the instrument scientist group into reality. One demonstration of past achievement is the highly ambitious and successful 2dF instrument that yielded invaluable scientific insight into the cosmological structure of the universe. The more recent successes of the instrumentation group include the OzPoz fiber positioner for the FLAMES facility on the VLT and the award-winning, imaging and multi-object IRIS-2 infrared spectrograph for the AAT. VPH gratings were first put into action in LDSS++ on the AAT and numerous VPH gratings are now in routine use on the 6dF spectrograph for the UKST. Under development are a completely new and unique fiber positioning scheme (Echidna) for use in the FMOS instrument for Subaru; a double-beamed, VPH-based, bench-mounted spectrograph for 2dF; new IR and optical detector controllers; a renovation of the telescope and instrument control systems for the AAT; and a feasibility study for an Echidna-style positioner for the Gemini telescopes. Several other design studies are underway for new instrument technologies using leading edge and innovative concepts in robotics and fibers. The synergy between our scientists and engineers establishes a sound basis for solving the instrumentation challenges facing us.

  3. Infrared Instrument for Detecting Hydrogen Fires

    NASA Technical Reports Server (NTRS)

    Youngquist, Robert; Ihlefeld, Curtis; Immer, Christopher; Oostdyk, Rebecca; Cox, Robert; Taylor, John

    2006-01-01

    The figure shows an instrument incorporating an infrared camera for detecting small hydrogen fires. The instrument has been developed as an improved replacement for prior infrared and ultraviolet instruments used to detect hydrogen fires. The need for this or any such instrument arises because hydrogen fires (e.g., those associated with leaks from tanks, valves, and ducts) pose a great danger, yet they emit so little visible light that they are mostly undetectable by the unaided human eye. The main performance advantage offered by the present instrument over prior hydrogen-fire-detecting instruments lies in its greater ability to avoid false alarms by discriminating against reflected infrared light, including that originating in (1) the Sun, (2) welding torches, and (3) deliberately ignited hydrogen flames (e.g., ullage-burn-off flames) that are nearby but outside the field of view intended to be monitored by the instrument. Like prior such instruments, this instrument is based mostly on the principle of detecting infrared emission above a threshold level. However, in addition, this instrument utilizes information on the spatial distribution of infrared light from a source that it detects. Because the combination of spatial and threshold information about a flame tends to constitute a unique signature that differs from that of reflected infrared light originating in a source not in the field of view, the incidence of false alarms is reduced substantially below that of related prior threshold- based instruments.

  4. Overview of coal conversion process instrumentation

    SciTech Connect

    Liptak, B. G.; Leiter, C. P.

    1980-05-01

    A review of standard instrumentation used in the processing industries is given, and the applicability of this instrumentation to measurements in mixed phase media and hostile environments such as those encountered in coal conversion processes is considered. The major projects in coal conversion sponsored by the US Department of Energy are briefly reviewed with schematics to pinpoint areas where the standard instrumentation is inadequate or altogether lacking. The next report in this series will provide detailed requirements on the instruments needed for these processes, will review new instruments which have recently become commercially available but are not yet considered standard instrumentation, and report on the status of new instruments which are being developed and, in some cases, undergoing tests in coal conversion plants.

  5. Instrumentation Manuals On-Line

    NASA Astrophysics Data System (ADS)

    Bryson, E.

    This database will serve as an international clearing house for observatory manuals and information on how to access them. At present, CFHT, STScI, and IRTF are participating in this project. It is the author's intention that each observatory will submit electronically a pre-formatted template which is now available on NCSA Mosaic (URL http://www.cfht.hawaii.edu/html/obs-manuals.html). The template describes the instrumentation manual in the following manner: location, version, revision, institution, description wavelength region, field, keywords, contact person, size of document, figures, tables and availability. In addition the template provides the user with a direct link to the manual if it is on-line. The project author will contact the individual or institution in charge of the template at six month intervals in order to insure the manual's accuracy. It is hoped the availability of this service will encourage all observatories to make information about their manuals available electronically.

  6. Asteroid electrostatic instrumentation and modelling

    NASA Astrophysics Data System (ADS)

    Aplin, K. L.; Bowles, N. E.; Urbak, E.; Keane, D.; Sawyer, E. C.

    2011-06-01

    Asteroid surface material is expected to become photoelectrically charged, and is likely to be transported through electrostatic levitation. Understanding any movement of the surface material is relevant to proposed space missions to return samples to Earth for detailed isotopic analysis. Motivated by preparations for the Marco Polo sample return mission, we present electrostatic modelling for a real asteroid, Itokawa, for which detailed shape information is available, and verify that charging effects are likely to be significant at the terminator and at the edges of shadow regions for the Marco Polo baseline asteroid, 1999JU3. We also describe the Asteroid Charge Experiment electric field instrumentation intended for Marco Polo. Finally, we find that the differing asteroid and spacecraft potentials on landing could perturb sample collection for the short landing time of 20min that is currently planned.

  7. RECENT DEVELOPMENTS IN HYDROLOGIC INSTRUMENTATION.

    USGS Publications Warehouse

    Latkovich, Vito J.

    1985-01-01

    The availability of space-age materials and implementation of state-of-the-art electronics is making possible the recent developments of hydrologic instrumentation. Material developments include: Synthetic-fiber sounding and tag lines; fiberglass wading rod; polymer (plastic) sheaves, pulleys and sampler components; and polymer (plastic) bucket wheels for current meters. These materials are very cost effective and efficient. Electromechanical and electronic developments and applications include: adaptable data acquisition system; downhole sampler for hazardous substances; current-meter digitizer; hydraulic power/drive system for discharge measurements and water-quality sampling; non-contact water-level sensors; minimum data recorder; acoustic velocity meters, and automated current meter discharge-measurement system.

  8. Application of Fiber Optic Instrumentation

    NASA Technical Reports Server (NTRS)

    Richards, William Lance; Parker, Allen R., Jr.; Ko, William L.; Piazza, Anthony; Chan, Patrick

    2012-01-01

    Fiber optic sensing technology has emerged in recent years offering tremendous advantages over conventional aircraft instrumentation systems. The advantages of fiber optic sensors over their conventional counterparts are well established; they are lighter, smaller, and can provide enormous numbers of measurements at a fraction of the total sensor weight. After a brief overview of conventional and fiber-optic sensing technology, this paper presents an overview of the research that has been conducted at NASA Dryden Flight Research Center in recent years to advance this promising new technology. Research and development areas include system and algorithm development, sensor characterization and attachment, and real-time experimentally-derived parameter monitoring for ground- and flight-based applications. The vision of fiber optic smart structure technology is presented and its potential benefits to aerospace vehicles throughout the lifecycle, from preliminary design to final retirement, are presented.

  9. Het testen van een 1 kW De Nora vaste polymeer elekrolyt brandstofcel voor toepassing op oppervlakteschepen. Deel 2. Eindrapport fase 1 (Testing of a 1kW De Nora Solid Polymer Electrolyte Fuel Cell for Application on Board of Naval Surface Ships. Part 2. Final Report, Phase I).

    DTIC Science & Technology

    2007-11-02

    electrolyte fuel cell (PEFC) has good chances for this application also for application on board of ships. A 1 kW PEFC stack was purchased from the...Italian firm De Nora to obtain practical experience with this type of stack. Via a dedicated computer controlled fuel cell test system the fuel cell can...150 A) and 83% (0 A). The tested fuel cell meets the given vibration and shock requirements and shows no sign of damage at pressure differences up to 10 bars between the hydrogen and air compartment.

  10. Strategy Differences in Map Information Use for Route Following in Unfamiliar Cities; Implications for In-Car Navigation Systems (Strategieverschillen in Kaart-Informatiegebruik bij het Volgen van Routes in Onbekends Steden; Implicaties voor Navigatie-Systemen in Auto’s)

    DTIC Science & Technology

    1990-04-03

    Technology, INRETS-LEN, Philips Research Laboratories, Saab/Scania, TNO Institute for Perception, YARD Ltd., NRC-Applied Psychology Unit, Tregie...Renault Regie, Swedish Road and Traffic Researh Institute VTI, Universitat der Bundeswehr HMnchen, and University College Dublin are represented as...Siegel, A.W., and Rosin’ki, R.R. (1978). The role of perceptual context in structuring spatial knowledge. Journal of Experimental Psychology : H-Aar

  11. MC and A instrumentation catalog

    SciTech Connect

    Neymotin, L.; Sviridova, V.

    1998-06-01

    In 1981 and 1985, two editions of a catalog of non-destructive nuclear measurement instrumentation, and material control and surveillance equipment, were published by Brookhaven National Laboratory (BNL). The last edition of the catalog included one hundred and twenty-five entries covering a wide range of devices developed in the US and abroad. More than ten years have elapsed since the publication of the more recent Catalog. Devices described in it have undergone significant modifications, and new devices have been developed. Therefore, in order to assist specialists in the field of Material Control and Accounting (MC and A), a new catalog has been created. Work on this instrumentation catalog started in 1997 as a cooperative effort of Brookhaven National Laboratory (BNL), operated by Brookhaven Science Associates under contract to the US Department of Energy, and the All-Russian Research Institute of Automatics (VNIIA), subordinate institute of the Atomic Energy Ministry of the Russian Federation, within the collaborative US-Russia Material Protection, Control, and Accounting (MPC and A) Program. Most of the equipment included in the Catalog are non-destructive assay (NDA) measurement devices employed for purposes of accounting, confirmation, and verification of nuclear materials. Other devices also included in the Catalog are employed in the detection and deterrence of unauthorized access to or removal of nuclear materials (material control: containment and surveillance). Equipment found in the Catalog comprises either: (1) complete devices or systems that can be used for MC and A applications; or (2) parts or components of complete systems, such as multi-channel analyzers, detectors, neutron generators, and software. All devices are categorized by their status of development--from prototype to serial production.

  12. Updated Guidelines for ANSS Instruments

    NASA Astrophysics Data System (ADS)

    Evans, J. R.; Hutt, C. R.; Gee, L. S.

    2014-12-01

    In 2008 the Advanced National Seismic System (ANSS) of the U.S. Geological Survey (USGS) and cooperating universities and institutions issued USGS Open-File Report 2008-1262 (OFR) containing detailed guidelines for the performance of instrumentation to be used by the ANSS. Here we report an update underway to these guidelines to take account of lessons learned, changing technology, and expanding user desires; in a few instances, performance matters that are very hard to test in practice are either modified or removed. Instrument classes are defined in the OFR in terms of amplitude resolution and cost; because relevant technologies have advanced substantially in these six years and a number of groups have begun to explore the use of relatively inexpensive, entirely host installed and operated Class C systems, the guidelines for strong-motion sensors are being expanded to include detailed guidelines for them rather than just anticipating them. As always, Class A systems will form the state-of-the-art backbone of any network, with Class B filling in spatially and in areas otherwise not covered well. Class C systems would be an additional step in making networks denser by providing very inexpensive hardware, installation, and maintenance to fill in additionally between Class A and B sites, for example in a high-seismicity urban area, with Class A sites every 4-6 km, Class B every 2-3 km, and Class C at <1 km spacing. Class C devices would be both installed and maintained by hosts, not institutions, and therefore also would be economical for extending coverage in regions with widely spaced or rare large seismicity, such as the central and eastern U.S.

  13. Recent Developments in PET Instrumentation

    PubMed Central

    Peng, Hao; Levin, Craig S.

    2013-01-01

    Positron emission tomography (PET) is used in the clinic and in vivo small animal research to study molecular processes associated with diseases such as cancer, heart disease, and neurological disorders, and to guide the discovery and development of new treatments. This paper reviews current challenges of advancing PET technology and some of newly developed PET detectors and systems. The paper focuses on four aspects of PET instrumentation: high photon detection sensitivity; improved spatial resolution; depth-of-interaction (DOI) resolution and time-of-flight (TOF). Improved system geometry, novel non-scintillator based detectors, and tapered scintillation crystal arrays are able to enhance the photon detection sensitivity of a PET system. Several challenges for achieving high resolution with standard scintillator-based PET detectors are discussed. Novel detectors with 3-D positioning capability have great potential to be deployed in PET for achieving spatial resolution better than 1 mm, such as cadmium-zinc-telluride (CZT) and position-sensitive avalanche photodiodes (PSAPDs). DOI capability enables a PET system to mitigate parallax error and achieve uniform spatial resolution across the field-of-view (FOV). Six common DOI designs, as well as advantages and limitations of each design, are discussed. The availability of fast scintillation crystals such as LaBr3, and the silicon photomultiplier (SiPM) greatly advances TOF-PET development. Recent instrumentation and initial results of clinical trials are briefly presented. If successful, these technology advances, together with new probe molecules, will substantially enhance the molecular sensitivity of PET and thus increase its role in preclinical and clinical research as well as evaluating and managing disease in the clinic. PMID:20497121

  14. ({sup 3}He,t) reaction on the double {beta} decay nucleus {sup 48}Ca and the importance of nuclear matrix elements

    SciTech Connect

    Grewe, E.-W.; Frekers, D.; Rakers, S.; Baeumer, C.; Dohmann, H.; Thies, J.; Adachi, T.; Fujita, Y.; Shimbara, Y.; Botha, N. T.; Fujita, H.; Hatanaka, K.; Nakanishi, K.; Sakemi, Y.; Shimizu, Y.; Tameshige, Y.; Tamii, A.; Negret, A.; Popescu, L.; Neveling, R.

    2007-11-15

    High-resolution ({sup 3}He,t) measurements on the double {beta}-decay ({beta}{beta}) nucleus {sup 48}Ca have been performed at RCNP (Osaka, Japan) to determine Gamow-Teller (GT{sup -}) transitions to the nucleus {sup 48}Sc, which represents the intermediate nucleus in the second-order perturbative description of the {beta}{beta} decay. At a bombarding energy of E{sub {sup 3}He}=420 MeV an excitation energy resolution of 40 keV was achieved. The measurements were performed at two angle positions of the Grand Raiden Spectrometer (GRS): 0 deg. and 2.5 deg. The results of both settings were combined to achieve angular distributions, by which the character of single transitions could be determined. To characterize the different multipoles, theoretical angular distributions for states with J{sup {pi}}=1{sup +},2{sup +},2{sup -}, and 3{sup +} were calculated using the distorted-wave Born approximation (DWBA) Code DW81. The GT{sup -} strength was extracted up to E{sub x}=7 MeV and combined with corresponding GT{sup +} strength deduced from the {sup 48}Ti(d,{sup 2}He){sup 48}Sc data to calculate the low-energy part of the {beta}{beta}-decay matrix element for the {sup 48}Ca 2{nu}{beta}{beta} decay. We show that after applying trivial momentum corrections to the ({sup 3}He,t) spectrum, the two reaction probes (p,n) and ({sup 3}He,t) reveal a spectral response to an impressively high degree of similarity in the region of low momentum transfer.

  15. Boosting Immune Responses Against Bacterial Pathogens: In Vitro Analysis of Immunomodulators (In Vitro Analyse van de Stimulerende Werking van Verschillende Stoffen op het Immuunsysteem)

    DTIC Science & Technology

    2007-07-01

    Distribution list Onderstaande instanties/personen ontvangen een volledig exernplaar van het rapport. 1 DMO/SC-DR&D standaard inclusief digitale versie...Directeur Militaire Gezondheidszorg 9 CDCIBGGZ Kol-arts H.A. Gerretsen MPH 10 CDCfBGGZ/CEMG A.S. de Koning, arts standaard inclusief digitale versie...Ltkol C.A. Bourgondie n standaard inclusief digitale versie bijgeleverd op cd-rom 16 Mindef/DMO/DWS&B/RLS&B/Logistieke systemen Kol ir. M.B.G. Mulder

  16. THOR Electric Field Instrument - EFI

    NASA Astrophysics Data System (ADS)

    Khotyaintsev, Yuri; Bale, Stuart D.; Bonnell, John W.; Lindqvist, Per-Arne; Phal, Yamuna; Rothkaehl, Hanna; Soucek, Jan; Vaivads, Andris; Åhlen, Lennart

    2016-04-01

    Turbulence Heating ObserveR (THOR) is the first mission ever flown in space dedicated to plasma turbulence. The Electric Field Instrument (EFI) will measure the vector electric field from 0 to 200 kHz. EFI consists of two sets of sensors: Spin-plane Double Probes (EFI-SDP) providing high sensitivity DC electric field in the spacecraft spin plane (2D), and the High-Frequency Antenna (EFI-HFA) providing 3D electric field at frequencies above ~1 kHz. EFI-SDP consists of 4 biased spherical probes extended on 50 m long wire booms, 90 degrees apart in the spin plane, giving a 100 m baseline for each of the two spin-plane electric field components. EFI-HFA consists of 6 x 1.25 m long monopoles, forming 3 dipolar antennas crossed at 90 degrees to each other. In addition to the sensors, EFI contains HFA and SDP pre-amplifiers, as well as bias electronics boards (BEBs) hosted in the man electronics box of the Field and Wave processor (FWP). As THOR spacecraft has a sun-pointing spin axis, EFI-SDP measures the electric field in the plane approximately orthogonal to the sun using long wire booms. The sun-pointing attitude greatly reduces errors due to wake effects and asymmetric photoelectron clouds, enabling the highly accurate in comparison to earlier missions ±0.1 mV/m near-DC electric field measurements. Interferometry using the electric field probes can be used to infer wavelengths and scale sizes at the smallest scales in the plasma. EFI also measures the floating potential of the satellite, which can be used to estimate the plasma density at very high time resolution (up to a few hundred Hz). The sun-pointing attitude greatly reduces changes in the illuminated area, and hence the associated spin-dependent errors. In combination with densities derived from the observed plasma frequency emission line, EFI monitors the plasma density from DC to a few hundred Hz. EFI measurements characterize electric field and density variations associated with kinetic scale plasma

  17. The Magnetometer Instrument on MESSENGER

    NASA Astrophysics Data System (ADS)

    Anderson, Brian J.; Acuña, Mario H.; Lohr, David A.; Scheifele, John; Raval, Asseem; Korth, Haje; Slavin, James A.

    2007-08-01

    The Magnetometer (MAG) on the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission is a low-noise, tri-axial, fluxgate instrument with its sensor mounted on a 3.6-m-long boom. The boom was deployed on March 8, 2005. The primary MAG science objectives are to determine the structure of Mercury’s intrinsic magnetic field and infer its origin. Mariner 10 observations indicate a planetary moment in the range 170 to 350 nT R {M/3} (where R M is Mercury’s mean radius). The uncertainties in the dipole moment are associated with the Mariner 10 trajectory and variability of the measured field. By orbiting Mercury, MESSENGER will significantly improve the determination of dipole and higher-order moments. The latter are essential to understanding the thermal history of the planet. MAG has a coarse range, ±51,300 nT full scale (1.6-nT resolution), for pre-flight testing, and a fine range, ±1,530 nT full scale (0.047-nT resolution), for Mercury operation. A magnetic cleanliness program was followed to minimize variable and static spacecraft-generated fields at the sensor. Observations during and after boom deployment indicate that the fixed residual field is less than a few nT at the location of the sensor, and initial observations indicate that the variable field is below 0.05 nT at least above about 3 Hz. Analog signals from the three axes are low-pass filtered (10-Hz cutoff) and sampled simultaneously by three 20-bit analog-to-digital converters every 50 ms. To accommodate variable telemetry rates, MAG provides 11 output rates from 0.01 s-1 to 20 s-1. Continuous measurement of fluctuations is provided with a digital 1-10 Hz bandpass filter. This fluctuation level is used to trigger high-time-resolution sampling in eight-minute segments to record events of interest when continuous high-rate sampling is not possible. The MAG instrument will provide accurate characterization of the intrinsic planetary field, magnetospheric structure, and

  18. Attention is necessary for subliminal instrumental conditioning.

    PubMed

    Mastropasqua, Tommaso; Turatto, Massimo

    2015-08-10

    The capacity of humans and other animals to provide appropriate responses to stimuli anticipating motivationally significant events is exemplified by instrumental conditioning. Interestingly, in humans instrumental conditioning can occur also for subliminal outcome-predicting stimuli. However, it remains unclear whether attention is necessary for subliminal instrumental conditioning to take place. In two experiments, human participants had to learn to collect rewards (monetary gains) while avoiding punishments (monetary losses), on the basis of subliminal outcome-predicting cues. We found that instrumental conditioning can proceed subconsciously only if spatial attention is aligned with the subliminal cue. Conversely, if spatial attention is briefly diverted from the subliminal cue, then instrumental conditioning is blocked. In humans, attention but not awareness is therefore mandatory for instrumental conditioning, thus revealing a dissociation between awareness and attention in the control of motivated behavior.

  19. Childhood adversity: a review of measurement instruments.

    PubMed

    Burgermeister, Diane

    2007-01-01

    Measurement instruments are needed to stimulate research on the long-term outcomes of childhood adversity. Therefore, the purpose of this review was to locate, describe, and assess instruments to measure retrospective perceptions of childhood adversity. An electronic search of instruments was conducted using a combination of keywords that included child maltreatment, child trauma, and childhood stressful events. Nine instruments were located and described according to format, definition of childhood adversity as measured by the instrument, characteristics of the sample used in development and testing, reliability and validity evidence, and feasibility for use. Six out of the nine instruments were suitable for investigators who require a comprehensive measure of childhood adversity. Corroboration with independent sources and use of randomized samples are needed to improve upon reports of validity.

  20. Care and sterilization of endourologic instruments.

    PubMed

    Gregory, E; Simmons, D; Weinberg, J J

    1988-08-01

    All endourologic instruments must be handled properly if they are to continue to function properly. Care must be taken in washing and sterilizing of this equipment, as not all endoscopic equipment can endure all methods, and people who are working with these instruments must be taught the proper care and sterilization methods of each. For example, fiberoptic telescopes and light cables must never be autoclaved; ethylene oxide is the method of choice. Disinfectant is an alternative. Loops, sheaths, high-frequency cables, resectoscopes, and working elements should be sterilized by ethylene oxide. Loops and high-frequency cables should not be soaked in a disinfectant, but other instruments may be soaked. All instruments should be dried before sterilization. Too much emphasis cannot be placed on the importance of proper storage of these very fragile fiberoptic instruments. With proper care and sterilization, these instruments will need fewer repairs and function properly for a longer time.

  1. The hen's egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of a cysteamine-containing gel: Quantification using Photoshop® and ImageJ.

    PubMed

    McKenzie, Barbara; Kay, Graeme; Matthews, Kerr H; Knott, Rachel M; Cairns, Donald

    2015-07-25

    A modified hen's egg chorioallantoic membrane (HET-CAM) test has been developed, combining ImageJ analysis with Adobe(®) Photoshop(®). The irritation potential of an ophthalmic medicine can be quantified using this method, by monitoring damage to blood vessels. The evaluation of cysteamine containing hyaluronate gel is reported. The results demonstrated that the novel gel formulation is non-irritant to the ocular tissues, in line with saline solution (negative control). In conclusion, the modification of the established HET-CAM test can quantify the damage to minute blood vessels. These results offer the possibility to formulate cysteamine in an ocular applicable gel formulation.

  2. Overview of the ESO instrumentation programme

    NASA Astrophysics Data System (ADS)

    Casali, Mark M.; Pasquini, Luca; Ramsay, Suzanne

    2012-09-01

    The ESO instrumentation programme now encompasses both an on-going programme for La-Silla Paranal observatory and a new programme for construction of the instruments for the E-ELT. The scale and ambition of the combined programme will present a future challenge for the European instrument-building community and for ESO as managing organisation. The current status and plans are summarised.

  3. Dental Diamond Rotary Instruments. Test and Evaluation

    DTIC Science & Technology

    1983-09-01

    Service, USAF School of Aerospace Med- icine. 17. DISTRIBUTION STATEMENT (of the ebetract entered In Block 20, it different from Report) 13...SUPPLEMENTARY NOTES 19. KEY WORDS (Continue on reverse ide iI neceseay and identify by block number) Dental diamond rotary instruments Diamond instrument cutting...performance Diamond instrument quality ABS.TLRACT fConi on, revere aide It neceeary aid Identify by block number) -’In this test and evaluation of the

  4. Operation and performance of the OSSE instrument

    NASA Astrophysics Data System (ADS)

    Cameron, R. A.; Kurfess, J. D.; Johnson, W. N.; Kinzer, R. L.; Kroeger, R. A.; Leising, M. D.; Murphy, R. J.; Share, G. H.; Strickman, M. S.; Grove, J. E.

    1992-02-01

    The Oriented Scintillation Spectrometer Experiment (OSSE) on the Arthur Holly Compton Gamma Ray Observatory is described. An overview of the operation and control of the instrument is given, together with a discussion of typical observing strategies used with OSSE and basic data types produced by the instrument. Some performance measures for the instrument are presented that were obtained from pre-launch and in-flight data. These include observing statistics, continuum and line sensitivity, and detector effective area and gain stability.

  5. Operation and performance of the OSSE instrument

    NASA Technical Reports Server (NTRS)

    Cameron, R. A.; Kurfess, J. D.; Johnson, W. N.; Kinzer, R. L.; Kroeger, R. A.; Leising, M. D.; Murphy, R. J.; Share, G. H.; Strickman, M. S.; Grove, J. E.

    1992-01-01

    The Oriented Scintillation Spectrometer Experiment (OSSE) on the Arthur Holly Compton Gamma Ray Observatory is described. An overview of the operation and control of the instrument is given, together with a discussion of typical observing strategies used with OSSE and basic data types produced by the instrument. Some performance measures for the instrument are presented that were obtained from pre-launch and in-flight data. These include observing statistics, continuum and line sensitivity, and detector effective area and gain stability.

  6. Instruments for Evaluating the Intervehicular Information System

    DTIC Science & Technology

    1990-12-01

    Xenia Road ATTN: PERI-IK Dayton, OH 45432-1894 Fort Knox, KY 40121-56,20 8a. NAME OF FUNDING/SPONSORING 8b. OFFICE SYMBOL 9. PROCUREMENT INSTRUMENT ...NO. NO. ACCESSION NO. 63007A 795 3101 C2 1 f :" LE (Include Security Classification) Instruments for Evaluating the Intervehicular Information System...and identify by block number) This research note includes copies of all test instruments used in a recent U.S. Army Research Institute-sponsored

  7. Status of the JWST Science Instrument Payload

    NASA Technical Reports Server (NTRS)

    Greenhouse, Matt

    2016-01-01

    The James Webb Space Telescope (JWST) Integrated Science Instrument Module (ISIM) system consists of five sensors (4 science): Mid-Infrared Instrument (MIRI), Near Infrared Imager and Slitless Spectrograph (NIRISS), Fine Guidance Sensor (FGS), Near InfraRed Camera (NIRCam), Near InfraRed Spectrograph (NIRSpec); and nine instrument support systems: Optical metering structure system, Electrical Harness System; Harness Radiator System, ISIM Electronics Compartment, ISIM Remote Services Unit, Cryogenic Thermal Control System, Command and Data Handling System, Flight Software System, Operations Scripts System.

  8. Hydrologic research on instrumented watersheds

    USGS Publications Warehouse

    Leopold, Luna Bergere

    1970-01-01

    The successful research man is the one who asks himself the right question. Research must go on primarily in the mind and only secondarily in the physical and biological world. It is only too easy to confuse the choice of a proper tool and the choice of a proper question. Some tools are quite unsuited to certain questions and some questions cannot be answered without the appropriate tool.There has been in recent years a large amount of discussion about whether the high costs and the extensive time period required for experimental watershed* research is really worth the investment. Recent discussions of this matter have cited as major criticisms of the instrumented basin that they are expensive, they leak water, they are unrepresentative, they produce changes too small for detection, and it is difficult to transfer the results. (See Hewlett, Lull, and Reinhart, 1969.) These are all questions worth talking about, but in one sense they tend to obscure the main issue. The main issue is what do we want to learn? If we can decide what it is we want to know, then we can logically ask ourselves what is the best way of going about obtaining that knowledge. It is in this context that we are most likely to place the experimental watershed in a useful and logical position in a classification of research methods.

  9. Magnetoresistive sensors for string instruments

    NASA Astrophysics Data System (ADS)

    Lenssen, K.-M. H.; Somers, G. H. J.; van Zon, J. B. A. D.

    2002-05-01

    Pickup elements for string instruments, in particular for electric guitars, represent a new application area for magnetoresistive sensors. Recently we developed a sensor configuration with permanent magnets for this purpose. For the first experiments we used commercial anisotropic magnetoresistance sensors (Philips KMZ10) mounted on small ferrite bias magnets. Recently we equipped an electric guitar with prototypes comprising giant magnetoresistance (GMR) sensors. These prototype MR pickup elements showed several clear advantages compared to the presently commonly used inductive pickup units. They are much less sensitive to disturbing electromagnetic fields (>1000×at 5 kHz), mainly because their active sensor area is several orders of magnitude smaller (a few mm2 instead of cm2). Also the larger freedom in the choice of the permanent magnets (due to the larger sensitivity of the GMR elements) is advantageous: employing smaller magnets reduces the damping and thus significantly improves the sustain, the magnets can be less expensive and more stable magnet materials can be chosen so that aging effects are eliminated.

  10. Instrumentation, Control, and Intelligent Systems

    SciTech Connect

    Not Available

    2005-09-01

    Abundant and affordable energy is required for U.S. economic stability and national security. Advanced nuclear power plants offer the best near-term potential to generate abundant, affordable, and sustainable electricity and hydrogen without appreciable generation of greenhouse gases. To that end, Idaho National Laboratory (INL) has been charged with leading the revitalization of nuclear power in the U.S. The INL vision is to become the preeminent nuclear energy laboratory with synergistic, world-class, multi-program capabilities and partnerships by 2015. The vision focuses on four essential destinations: (1) Be the preeminent internationally-recognized nuclear energy research, development, and demonstration laboratory; (2) Be a major center for national security technology development and demonstration; (3) Be a multi-program national laboratory with world-class capabilities; (4) Foster academic, industry, government, and international collaborations to produce the needed investment, programs, and expertise. Crucial to that effort is the inclusion of research in advanced instrumentation, control, and intelligent systems (ICIS) for use in current and advanced power and energy security systems to enable increased performance, reliability, security, and safety. For nuclear energy plants, ICIS will extend the lifetime of power plant systems, increase performance and power output, and ensure reliable operation within the system's safety margin; for national security applications, ICIS will enable increased protection of our nation's critical infrastructure. In general, ICIS will cost-effectively increase performance for all energy security systems.

  11. The JEM-EUSO instrument

    NASA Astrophysics Data System (ADS)

    Adams, J. H.; Ahmad, S.; Albert, J.-N.; Allard, D.; Anchordoqui, L.; Andreev, V.; Anzalone, A.; Arai, Y.; Asano, K.; Ave Pernas, M.; Baragatti, P.; Barrillon, P.; Batsch, T.; Bayer, J.; Bechini, R.; Belenguer, T.; Bellotti, R.; Belov, K.; Berlind, A. A.; Bertaina, M.; Biermann, P. L.; Biktemerova, S.; Blaksley, C.; Blanc, N.; Błȩcki, J.; Blin-Bondil, S.; Blümer, J.; Bobik, P.; Bogomilov, M.; Bonamente, M.; Briggs, M. S.; Briz, S.; Bruno, A.; Cafagna, F.; Campana, D.; Capdevielle, J.-N.; Caruso, R.; Casolino, M.; Cassardo, C.; Castellinic, G.; Catalano, C.; Catalano, G.; Cellino, A.; Chikawa, M.; Christl, M. J.; Cline, D.; Connaughton, V.; Conti, L.; Cordero, G.; Crawford, H. J.; Cremonini, R.; Csorna, S.; Dagoret-Campagne, S.; de Castro, A. J.; De Donato, C.; de la Taille, C.; De Santis, C.; del Peral, L.; Dell'Oro, A.; De Simone, N.; Di Martino, M.; Distratis, G.; Dulucq, F.; Dupieux, M.; Ebersoldt, A.; Ebisuzaki, T.; Engel, R.; Falk, S.; Fang, K.; Fenu, F.; Fernández-Gómez, I.; Ferrarese, S.; Finco, D.; Flamini, M.; Fornaro, C.; Franceschi, A.; Fujimoto, J.; Fukushima, M.; Galeotti, P.; Garipov, G.; Geary, J.; Gelmini, G.; Giraudo, G.; Gonchar, M.; González Alvarado, C.; Gorodetzky, P.; Guarino, F.; Guzmán, A.; Hachisu, Y.; Harlov, B.; Haungs, A.; Hernández Carretero, J.; Higashide, K.; Ikeda, D.; Ikeda, H.; Inoue, N.; Inoue, S.; Insolia, A.; Isgrò, F.; Itow, Y.; Joven, E.; Judd, E. G.; Jung, A.; Kajino, F.; Kajino, T.; Kaneko, I.; Karadzhov, Y.; Karczmarczyk, J.; Karus, M.; Katahira, K.; Kawai, K.; Kawasaki, Y.; Keilhauer, B.; Khrenov, B. A.; Kim, J.-S.; Kim, S.-W.; Kim, S.-W.; Kleifges, M.; Klimov, P. A.; Kolev, D.; Kreykenbohm, I.; Kudela, K.; Kurihara, Y.; Kusenko, A.; Kuznetsov, E.; Lacombe, M.; Lachaud, C.; Lee, J.; Licandro, J.; Lim, H.; López, F.; Maccarone, M. C.; Mannheim, K.; Maravilla, D.; Marcelli, L.; Marini, A.; Martinez, O.; Masciantonio, G.; Mase, K.; Matev, R.; Medina-Tanco, G.; Mernik, T.; Miyamoto, H.; Miyazaki, Y.; Mizumoto, Y.; Modestino, G.; Monaco, A.; Monnier-Ragaigne, D.; Morales de los Ríos, J. A.; Moretto, C.; Morozenko, V. S.; Mot, B.; Murakami, T.; Murakami, M. Nagano; Nagata, M.; Nagataki, S.; Nakamura, T.; Napolitano, T.; Naumov, D.; Nava, R.; Neronov, A.; Nomoto, K.; Nonaka, T.; Ogawa, T.; Ogio, S.; Ohmori, H.; Olinto, A. V.; Orleański, P.; Osteria, G.; Panasyuk, M. I.; Parizot, E.; Park, I. H.; Park, H. W.; Pastircak, B.; Patzak, T.; Paul, T.; Pennypacker, C.; Perez Cano, S.; Peter, T.; Picozza, P.; Pierog, T.; Piotrowski, L. W.; Piraino, S.; Plebaniak, Z.; Pollini, A.; Prat, P.; Prévôt, G.; Prieto, H.; Putis, M.; Reardon, P.; Reyes, M.; Ricci, M.; Rodríguez, I.; Rodríguez Frías, M. D.; Ronga, F.; Roth, M.; Rothkaehl, H.; Roudil, G.; Rusinov, I.; Rybczyński, M.; Sabau, M. D.; Sáez-Cano, G.; Sagawa, H.; Saito, A.; Sakaki, N.; Sakata, M.; Salazar, H.; Sánchez, S.; Santangelo, A.; Santiago Crúz, L.; Sanz Palomino, M.; Saprykin, O.; Sarazin, F.; Sato, H.; Sato, M.; Schanz, T.; Schieler, H.; Scotti, V.; Segreto, A.; Selmane, S.; Semikoz, D.; Serra, M.; Sharakin, S.; Shibata, T.; Shimizu, H. M.; Shinozaki, K.; Shirahama, T.; Siemieniec-Oziȩbło, G.; Silva López, H. H.; Sledd, J.; Słomińska, K.; Sobey, A.; Sugiyama, T.; Supanitsky, D.; Suzuki, M.; Szabelska, B.; Szabelski, J.; Tajima, F.; Tajima, N.; Tajima, T.; Takahashi, Y.; Takami, H.; Takeda, M.; Takizawa, Y.; Tenzer, C.; Tibolla, O.; Tkachev, L.; Tokuno, H.; Tomida, T.; Tone, N.; Toscano, S.; Trillaud, F.; Tsenov, R.; Tsunesada, Y.; Tsuno, K.; Tymieniecka, T.; Uchihori, Y.; Unger, M.; Vaduvescu, O.; Valdés-Galicia, J. F.; Vallania, P.; Valore, L.; Vankova, G.; Vigorito, C.; Villaseñor, L.; von Ballmoos, P.; Wada, S.; Watanabe, J.; Watanabe, S.; Watts, J.; Weber, M.; Weiler, T. J.; Wibig, T.; Wiencke, L.; Wille, M.; Wilms, J.; Włodarczyk, Z.; Yamamoto, T.; Yamamoto, Y.; Yang, J.; Yano, H.; Yashin, I. V.; Yonetoku, D.; Yoshida, K.; Yoshida, S.; Young, R.; Zotov, M. Yu.; Zuccaro Marchi, A.

    2015-11-01

    In this paper we describe the main characteristics of the JEM-EUSO instrument. The Extreme Universe Space Observatory on the Japanese Experiment Module (JEM-EUSO) of the International Space Station (ISS) will observe Ultra High-Energy Cosmic Rays (UHECR) from space. It will detect UV-light of Extensive Air Showers (EAS) produced by UHECRs traversing the Earth's atmosphere. For each event, the detector will determine the energy, arrival direction and the type of the primary particle. The advantage of a space-borne detector resides in the large field of view, using a target volume of about 1012 tons of atmosphere, far greater than what is achievable from ground. Another advantage is a nearly uniform sampling of the whole celestial sphere. The corresponding increase in statistics will help to clarify the origin and sources of UHECRs and characterize the environment traversed during their production and propagation. JEM-EUSO is a 1.1 ton refractor telescope using an optics of 2.5 m diameter Fresnel lenses to focus the UV-light from EAS on a focal surface composed of about 5,000 multi-anode photomultipliers, for a total of ≃3ṡ105 channels. A multi-layer parallel architecture handles front-end acquisition, selecting and storing valid triggers. Each processing level filters the events with increasingly complex algorithms using FPGAs and DSPs to reject spurious events and reduce the data rate to a value compatible with downlink constraints.

  12. Biomagnetic Measurements Using SQUID Instrumentation

    NASA Astrophysics Data System (ADS)

    Rassi, D.; Zhuravlev, Y.

    2000-09-01

    Biomagnetic measurements involve the detection of the magnetic fields generated by physiological activity in living organisms. Because magnetic fields are sensed remotely, no physical contact with the subject is required, making the technique totally non-invasive Furthermore, only the magnetic fields originating within the body are measured. No external field is applied and it can therefore be confidently stated that the technique is completely safe. These characteristics make biomagnetometry an ideal tool for the investigation of physiological processes. The only magnetic field detector capable of measuring these extremely weak biomagnetic signals is the Superconducting Quantum Interference Device (SQUID). In the last thirty years SQUID-based ultrasensitive magnetometers have been widely used in the investigation of physiologically produced magnetic fields for diagnostic purposes. Owing to the numerous sources of noise and interference typical of an urban environment, it has until recently been considered almost impossible to operate a SQUID magnetometer in such a location without magnetic shielding. We have overcome these technical problems and have successfully used our specially developed unshielded SQUID systems in laboratory and hospital environments. This instrumentation is suitable for recording the biomagnetic fields in adults, neonates and fetuses, and has been applied in a number of clinical studies including fetal magnetocardiography.

  13. Surgical Instrument Restraint in Weightlessness

    NASA Technical Reports Server (NTRS)

    Campbell, Mark R.; Dawson, David L.; Melton, Shannon; Hooker, Dona; Cantu, Hilda

    2000-01-01

    Performing a surgical procedure during spaceflight will become more likely with longer duration missions in the near future. Minimal surgical capability has been present on previous missions as the definitive medical care time was short and the likelihood of surgical events too low to justify surgical hardware availability. Early demonstrations of surgical procedures in the weightlessness of parabolic flight indicated the need for careful logistical planning and restraint of surgical hardware. The consideration of human ergonomics also has more impact in weightlessness than in the conventionall-g environment. Three methods of surgical instrument restraint - a Minor Surgical Kit (MSK), a Surgical Restraint Scrub Suit (SRSS), and a Surgical Tray (ST) were evaluated in parabolic flight surgical procedures. The Minor Surgical Kit was easily stored, easily deployed, and demonstrated the best ability to facilitate a surgical procedure in weightlessness. Important factors in this surgical restraint system include excellent organization of supplies, ability to maintain sterility, accessibility while providing secure restraint, ability to dispose of sharp items and biological trash, and ergonomical efficiency.

  14. LISA Pathfinder instrument data analysis

    NASA Astrophysics Data System (ADS)

    Guzman, Felipe

    LISA Pathfinder (LPF) is an ESA-launched demonstration mission of key technologies required for the joint NASA-ESA gravitational wave observatory in space, LISA. As part of the LPF interferometry investigations, analytic models of noise sources and corresponding noise subtrac-tion techniques have been developed to correct for effects like the coupling of test mass jitter into displacement readout, and fluctuations of the laser frequency or optical pathlength difference. Ground testing of pre-flight hardware of the Optical Metrology Subsystem is currently ongoing at the Albert Einstein Institute Hannover. In collaboration with NASA Goddard Space Flight Center, the LPF mission data analysis tool LTPDA is being used to analyze the data product of these tests. Furthermore, the noise subtraction techniques and in-flight experiment runs for noise characterization are being defined as part of the mission experiment master plan. We will present the data analysis outcome of pre-flight hardware ground tests and possible noise subtraction strategies for in-flight instrument operations.

  15. LISA Pathfinder Instrument Data Analysis

    NASA Technical Reports Server (NTRS)

    Guzman, Felipe

    2010-01-01

    LISA Pathfinder (LPF) is an ESA-launched demonstration mission of key technologies required for the joint NASA-ESA gravitational wave observatory in space, LISA. As part of the LPF interferometry investigations, analytic models of noise sources and corresponding noise subtraction techniques have been developed to correct for effects like the coupling of test mass jitter into displacement readout, and fluctuations of the laser frequency or optical pathlength difference. Ground testing of pre-flight hardware of the Optical Metrology subsystem is currently ongoing at the Albert Einstein Institute Hannover. In collaboration with NASA Goddard Space Flight Center, the LPF mission data analysis tool LTPDA is being used to analyze the data product of these tests. Furthermore, the noise subtraction techniques and in-flight experiment runs for noise characterization are being defined as part of the mission experiment master plan. We will present the data analysis outcome of preflight hardware ground tests and possible noise subtraction strategies for in-flight instrument operations.

  16. Comet coma sample return instrument

    NASA Technical Reports Server (NTRS)

    Albee, A. L.; Brownlee, Don E.; Burnett, Donald S.; Tsou, Peter; Uesugi, K. T.

    1994-01-01

    The sample collection technology and instrument concept for the Sample of Comet Coma Earth Return Mission (SOCCER) are described. The scientific goals of this Flyby Sample Return are to return to coma dust and volatile samples from a known comet source, which will permit accurate elemental and isotopic measurements for thousands of individual solid particles and volatiles, detailed analysis of the dust structure, morphology, and mineralogy of the intact samples, and identification of the biogenic elements or compounds in the solid and volatile samples. Having these intact samples, morphologic, petrographic, and phase structural features can be determined. Information on dust particle size, shape, and density can be ascertained by analyzing penetration holes and tracks in the capture medium. Time and spatial data of dust capture will provide understanding of the flux dynamics of the coma and the jets. Additional information will include the identification of cosmic ray tracks in the cometary grains, which can provide a particle's process history and perhaps even the age of the comet. The measurements will be made with the same equipment used for studying micrometeorites for decades past; hence, the results can be directly compared without extrapolation or modification. The data will provide a powerful and direct technique for comparing the cometary samples with all known types of meteorites and interplanetary dust. This sample collection system will provide the first sample return from a specifically identified primitive body and will allow, for the first time, a direct method of matching meteoritic materials captured on Earth with known parent bodies.

  17. Comet coma sample return instrument

    NASA Astrophysics Data System (ADS)

    Albee, A. L.; Brownlee, Don E.; Burnett, Donald S.; Tsou, Peter; Uesugi, K. T.

    The sample collection technology and instrument concept for the Sample of Comet Coma Earth Return Mission (SOCCER) are described. The scientific goals of this Flyby Sample Return are to return to coma dust and volatile samples from a known comet source, which will permit accurate elemental and isotopic measurements for thousands of individual solid particles and volatiles, detailed analysis of the dust structure, morphology, and mineralogy of the intact samples, and identification of the biogenic elements or compounds in the solid and volatile samples. Having these intact samples, morphologic, petrographic, and phase structural features can be determined. Information on dust particle size, shape, and density can be ascertained by analyzing penetration holes and tracks in the capture medium. Time and spatial data of dust capture will provide understanding of the flux dynamics of the coma and the jets. Additional information will include the identification of cosmic ray tracks in the cometary grains, which can provide a particle's process history and perhaps even the age of the comet. The measurements will be made with the same equipment used for studying micrometeorites for decades past; hence, the results can be directly compared without extrapolation or modification. The data will provide a powerful and direct technique for comparing the cometary samples with all known types of meteorites and interplanetary dust. This sample collection system will provide the first sample return from a specifically identified primitive body and will allow, for the first time, a direct method of matching meteoritic materials captured on Earth with known parent bodies.

  18. New instruments for solar research

    NASA Technical Reports Server (NTRS)

    Rust, David M.; O'Byrne, John W.; Sterner, Raymond E., II

    1990-01-01

    In fulfilment of its goal to develop early detection and warning of emerging solar magnetic fields, the Center for Applied Solar Physics (CASP) has designed and constructed a solar vector magnetograph (VMG) that will provide unique data on the sunspot regions where flares originate. The instrument is reportedly beginning to approach its goals of measuring all three components of the solar magnetic field with a sensitivity of 50 to 100 G and a spatial resolution on the sun of about 700 km (1 arcsec). Importance of new high-resolution capabilities is stressed and the interpretation of VMG measurements is discussed. The performance of the solar VMG, installed in a 6-m dome at the National Solar Observatory at Sacramento Peak in Sunspot, New Mexico, and its construction and environment are described; particular attention is given to the use and function of the filters. Initial results are examined, including a description and analysis of a magnetogram obtained after installation of an improved blocking filter.

  19. Development of autonomous triggering instrumentation

    NASA Astrophysics Data System (ADS)

    Watkins, Steve E.; Swift, Theresa M.; Fonda, James W.

    2008-03-01

    Triggering instrumentation for autonomous monitoring of load-induced strain is described for economical, fast bridge inspection. The development addresses one aspect for the management of transportation infrastructure - bridge monitoring and inspection. The objectives are to provide quantitative performance information from a load test, to minimize the setup time at the bridge, and to minimize the closure time to traffic. Multiple or networked measurements can be made for a prescribed loading sequence. The proposed smart system consists of in-situ strain sensors, an embedded data acquisition module, and a measurement triggering system. A companion control unit is mounted on the truck serving as the load. As the truck moves to the proper position, the desired measurement is automatically relayed back to the control unit. In this work, the testing protocol is developed and the performance parameters for the triggering and data acquisition are measured. The test system uses a dedicated wireless sensor mote and an infrared positioning system. The electronic procedure offers improvements in available information and economics.

  20. Bubble measuring instrument and method

    NASA Technical Reports Server (NTRS)

    Kline-Schoder, Robert (Inventor); Magari, Patrick J. (Inventor)

    2003-01-01

    Method and apparatus are provided for a non-invasive bubble measuring instrument operable for detecting, distinguishing, and counting gaseous embolisms such as bubbles over a selectable range of bubble sizes of interest. A selected measurement volume in which bubbles may be detected is insonified by two distinct frequencies from a pump transducer and an image transducer, respectively. The image transducer frequency is much higher than the pump transducer frequency. The relatively low-frequency pump signal is used to excite bubbles to resonate at a frequency related to their diameter. The image transducer is operated in a pulse-echo mode at a controllable repetition rate that transmits bursts of high-frequency ultrasonic signal to the measurement volume in which bubbles may be detected and then receives the echo. From the echo or received signal, a beat signal related to the repetition rate may be extracted and used to indicate the presence or absence of a resonant bubble. In a preferred embodiment, software control maintains the beat signal at a preselected frequency while varying the pump transducer frequency to excite bubbles of different diameters to resonate depending on the range of bubble diameters selected for investigation.

  1. Bubble Measuring Instrument and Method

    NASA Technical Reports Server (NTRS)

    Kline-Schoder, Robert (Inventor); Magari, Patrick J. (Inventor)

    2002-01-01

    Method and apparatus are provided for a non-invasive bubble measuring instrument operable for detecting, distinguishing, and counting gaseous embolisms such as bubbles over a selectable range of bubble sizes of interest. A selected measurement volume in which bubbles may be detected is insonified by two distinct frequencies from a pump transducer and an image transducer. respectively. The image transducer frequency is much higher than the pump transducer frequency. The relatively low-frequency pump signal is used to excite bubbles to resonate at a frequency related to their diameter. The image transducer is operated in a pulse-echo mode at a controllable repetition rate that transmits bursts of high-frequency ultrasonic signal to the measurement volume in which bubbles may be detected and then receives the echo. From the echo or received signal, a beat signal related to the repetition rate may be extracted and used to indicate the presence or absence of a resonant bubble. In a preferred embodiment, software control maintains the beat signal at a preselected frequency while varying the pump transducer frequency to excite bubbles of different diameters to resonate depending on the range of bubble diameters selected for investigation.

  2. Electronic instrumentation for smart structures

    NASA Astrophysics Data System (ADS)

    Blanar, George J.

    1995-04-01

    The requirements of electronic instrumentation for smart structures are similar to those of data acquisition systems at our national particle physics laboratories. Modern high energy and heavy ion physics experiments may have tens of thousands of channels of data sources producing data that must be converted to digital form, compacted, stored and interpreted. In parallel, multiple sensors distributed in and around smart structures generate either binary or analog signals that are voltage, charge, or time like in their information content. In all cases, they must be transmitted, converted and preserved into a unified digital format for real-time processing. This paper will review the current status of practical large scale electronic measurement systems with special attention to architectures and physical organization. Brief surveys of the current state of the art will include preamplifiers and amplifiers, comparators and discriminators, voltage or charge analog-to-digital converters, time internal meters or time-to-digital converters, and finally, counting or scalar systems. The paper will conclude by integrating all of these ideas in a concept for an all-digital readout of a smart structure using the latest techniques used in physics research today.

  3. CICADA, CCD and Instrument Control Software

    NASA Astrophysics Data System (ADS)

    Young, Peter J.; Brooks, Mick; Meatheringham, Stephen J.; Roberts, William H.

    Computerised Instrument Control and Data Acquisition (CICADA) is a software system for control of telescope instruments in a distributed computing environment. It is designed using object-oriented techniques and built with standard computing tools such as RPC, SysV IPC, Posix threads, Tcl, and GUI builders. The system is readily extensible to new instruments and currently supports the Astromed 3200 CCD controller and MSSSO's new tip-tilt system. Work is currently underway to provide support for the SDSU CCD controller and MSSSO's Double Beam Spectrograph. A core set of processes handle common communication and control tasks, while specific instruments are ``bolted'' on using C++ inheritance techniques.

  4. HOST instrumentation R and D program overview

    NASA Technical Reports Server (NTRS)

    Englund, D. R.

    1986-01-01

    The HOST Instrumentation R and D program is focused on two categories of instrumentation. One category is that required to characterize the environment imposed on the hot section components of turbine engines. This category includes instruments for measuring gas flow, gas temperature, and heat flux. The second category is that for measuring the effect of the environment on the hot section components. This category includes strain measuring instruments and an optical system for viewing the interior of an operating combustor to detect cracks, buckling, carbon buildup, etc.

  5. Rotary mode system initial instrument calibration

    SciTech Connect

    Johns, B.R.

    1994-10-01

    The attached report contains the vendor calibration procedures used for the initial instrument calibration of the rotary core sampling equipment. The procedures are from approved vendor information files.

  6. Kids with disabilities inspire a musical instrument

    SciTech Connect

    Daily, Dan; Pfeifer, Kent

    2013-11-21

    The Midiwing is a musical instrument that unites music and computer technology for those who lack the experience, physical ability, or maturity to play music with traditional instruments. To create the instrument, Dan Daily, Director of Musicode Innovations, reworked and recoded Musical Instrument Digital Interface (MIDI) technology and introduced ergonomic design. He applied to the New Mexico Small Business Assistance (NMSBA) Program to receive help when he discovered the microcontroller he used was being phased out. Daily and Kent Pfeifer, an engineer at Sandia National Laboratories and musician himself, partnered to create a new state-of-the-art design.

  7. Kids with disabilities inspire a musical instrument

    ScienceCinema

    Daily, Dan; Pfeifer, Kent

    2016-07-12

    The Midiwing is a musical instrument that unites music and computer technology for those who lack the experience, physical ability, or maturity to play music with traditional instruments. To create the instrument, Dan Daily, Director of Musicode Innovations, reworked and recoded Musical Instrument Digital Interface (MIDI) technology and introduced ergonomic design. He applied to the New Mexico Small Business Assistance (NMSBA) Program to receive help when he discovered the microcontroller he used was being phased out. Daily and Kent Pfeifer, an engineer at Sandia National Laboratories and musician himself, partnered to create a new state-of-the-art design.

  8. Recent Topics in Instrumentation and Measurement

    NASA Astrophysics Data System (ADS)

    Tanabe, Kazuo; Hirose, Masanobu; Otani, Akihito; Mochizuki, Ken; Uchida, Masafumi

    Instrumentation and measurement play a vital role in research and development in the science and engineering fields. Recently, the goals of instrumentation and measurement have expanded to meet not only the industrial and science requirements but also the needs in all fields of social life, such as medicine and welfare, the environment, and disaster and security. In this article, the state of TC-IM (Technical Committee of Instrumentation and Measurement of IEEJ) activities and technical topics in the instrumentation and measurement field are reported, mainly referring to over seventy papers presented at the IM Technical Meeting.

  9. Realization of a Visual Surveillance System Used by Manoeuvres at Night, on the Combat Range ISK de Harskamp"

    DTIC Science & Technology

    2007-11-02

    Laboratorium TNO Prins Maurits Laboratorium Nederlandse Organisatie voor toegepast- natuurwetenschappetijk onderzoek TNO Management uittreksel TNO...ISK bij duisternis. Siemens Nederland BV. Siemens (1997). Gebruikshandleiding CCTV voor het project Waarneming gevechtsbaan ISK bij duisternis...Siemens Nederland BV. Stroethof, J.W. (1994). Studie beveiliging Harskamp (Rapport FEL 94-A115). ’s-Gravenhage: TNO Fysisch en Elektronisch Laboratorium

  10. Beslisbevoegdheden en Verantwoordelijkheden van de Uitgestegen Soldaat. Deel A: Verplaatsen van Beslisbevoegdheden (Authority and Responsibility of the Dismounted Soldier. Part A. Empowering the Dismounted Soldier)

    DTIC Science & Technology

    2007-04-01

    er steeds meer directe aandacht van politiek en media . De sociale interactie tussen de GPC en zijn groep en de lokale bevolking kunnen daardoor...eenheden (gereduceerd voor dit onderzoek). Niet-gevechtstaken 1 Verkenningepatrouille 2 Gevechtspatrouille 3 Bevelilgingspatrouille 4 Sociale en...de missie in Afghanistan is de smallest unit of action (SUA) het peloton. Dit geldt voor alle taken, dus ook voor sociale - en contactpatrouilles

  11. Development and Construction of a Camera System for Landmine Detection

    DTIC Science & Technology

    2005-11-25

    Ontwikkeling en vervaardiging van een camera systeem voor Iandmijn detectie Eindrapport de ’haalbaarheidsfase’ is de haalbaarheid van verschillende...demonstratiesysteem gebouwd. Dit demonstratie- systeem bestaat uit een polarisatiecamera die speciaal voor dit doel is ontwikkeld en vervaardigd. Daamaast is software...ontwikkeld voor de automnatische detectie van Iandmidjnen en de visual-isatie van de detectieresultaten. Om de werking van het systeem te demonstreren

  12. Images from Phoenix's MECA Instruments

    NASA Technical Reports Server (NTRS)

    2008-01-01

    The image on the upper left is from NASA's Phoenix Mars Lander's Optical Microscope after a sample informally called 'Sorceress' was delivered to its silicon substrate on the 38th Martian day, or sol, of the mission (July 2, 2008).

    A 3D representation of the same sample is on the right, as seen by Phoenix's Atomic Force Microscope. This is 200 times greater magnification than the view from the Optical Microscope, and the most highly magnified image ever seen from another world.

    The image shows four round pits, only 5 microns in depth, that were micromachined into the silicon substrate, which is the background plane shown in red. This image has been processed to reflect the levelness of the substrate.

    A Martian particle only one micrometer, or one millionth of a meter, across is held in the upper left pit.

    The rounded particle shown at the highest magnification ever seen from another world is a particle of the dust that cloaks Mars. Such dust particles color the Martian sky pink, feed storms that regularly envelop the planet and produce Mars' distinctive red soil.

    The Optical Microscope and the Atomic Force Microscope are part of Phoenix's Microscopy, Electrochemistry and Conductivity Analyzer instrument.

    The AFM was developed by a Swiss-led consortium, with Imperial College London producing the silicon substrate that holds sampled particles.

    The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  13. Aeronautic instruments. Section I : general classification of instruments and problems including bibliography

    NASA Technical Reports Server (NTRS)

    Hersey, Mayo D

    1923-01-01

    This report is intended as a technical introduction to the series of reports on aeronautic instruments. It presents a discussion of those subjects which are common to all instruments. First, a general classification is given, embracing all types of instruments used in aeronautics. Finally, a classification is given of the various problems confronted by the instrument expert and investigator. In this way the following groups of problems are brought up for consideration: problems of mechanical design, human factor, manufacturing problems, supply and selection of instruments, problems concerning the technique of testing, problems of installation, problems concerning the use of instruments, problems of maintenance, and physical research problems. This enumeration of problems which are common to instruments in general serves to indicate the different points of view which should be kept in mind in approaching the study of any particular instrument.

  14. An Analysis of Selected Skinfold Measuring Instruments.

    ERIC Educational Resources Information Center

    Hawkins, Jerald D.

    1983-01-01

    The performance of three relatively inexpensive skinfold calipers were compared with that of the Lange Skinfold Caliper. The instruments were used with 800 students ranging from elementary school to the college level. The Fat-O-Meter and Adipometer calipers compared favorably with the Lange instrument for accuracy and wearability while the…

  15. 40 CFR 201.22 - Measurement instrumentation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Measurement instrumentation. 201.22... PROGRAMS NOISE EMISSION STANDARDS FOR TRANSPORTATION EQUIPMENT; INTERSTATE RAIL CARRIERS Measurement Criteria § 201.22 Measurement instrumentation. (a) A sound level meter or alternate sound level...

  16. 40 CFR 201.22 - Measurement instrumentation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Measurement instrumentation. 201.22... PROGRAMS NOISE EMISSION STANDARDS FOR TRANSPORTATION EQUIPMENT; INTERSTATE RAIL CARRIERS Measurement Criteria § 201.22 Measurement instrumentation. (a) A sound level meter or alternate sound level...

  17. 40 CFR 201.22 - Measurement instrumentation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Measurement instrumentation. 201.22... PROGRAMS NOISE EMISSION STANDARDS FOR TRANSPORTATION EQUIPMENT; INTERSTATE RAIL CARRIERS Measurement Criteria § 201.22 Measurement instrumentation. (a) A sound level meter or alternate sound level...

  18. 40 CFR 201.22 - Measurement instrumentation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Measurement instrumentation. 201.22... PROGRAMS NOISE EMISSION STANDARDS FOR TRANSPORTATION EQUIPMENT; INTERSTATE RAIL CARRIERS Measurement Criteria § 201.22 Measurement instrumentation. (a) A sound level meter or alternate sound level...

  19. 40 CFR 201.22 - Measurement instrumentation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Measurement instrumentation. 201.22... PROGRAMS NOISE EMISSION STANDARDS FOR TRANSPORTATION EQUIPMENT; INTERSTATE RAIL CARRIERS Measurement Criteria § 201.22 Measurement instrumentation. (a) A sound level meter or alternate sound level...

  20. Nontraditional Intelligence Testing: Samples of Humorous Instruments.

    ERIC Educational Resources Information Center

    Lemire, David

    In keeping with a model of intelligence that identifies at least 12 intelligence "talents," formal and informal intelligence or talent assessments have been developed. This paper presents some of these informal instruments that can be used to assess convergent and divergent forms of intelligence. These nontraditional instruments have been designed…

  1. The Inclusive Instrumental Library: Works by Women.

    ERIC Educational Resources Information Center

    Palmquist, Jane E.; Payne, Barbara

    1992-01-01

    Observes that women's contributions to instrumental music frequently have been overlooked. Explains that, although women have written and performed music for string instruments for centuries, much of their work has been lost. Discusses some of the leading women composers. Suggests means of integrating women's works into the curriculum. Offers a…

  2. Achievement Goals, Learning Strategies and Instrumental Performance

    ERIC Educational Resources Information Center

    Nielsen, Siw Graabraek

    2008-01-01

    The current study is a survey of the achievement goals of music students and the manner in which their strategies and instrumental performance relate to these goals. In the context of advanced instrumental learning, the rationale for the present study was to contribute to the literature on motivation in music students, and thereby, help teachers…

  3. Instrument accurately measures weld angle and offset

    NASA Technical Reports Server (NTRS)

    Boyd, W. G.

    1967-01-01

    Weld angle is measured to the nearest arc minute and offset to one thousandth of an inch by an instrument designed to use a reference plane at two locations on a test coupon. A special table for computation has been prepared for use with the instrument.

  4. Reading Instruments: Objects, Texts and Museums

    ERIC Educational Resources Information Center

    Anderson, Katharine; Frappier, Melanie; Neswald, Elizabeth; Trim, Henry

    2013-01-01

    Science educators, historians of science and their students often share a curiosity about historical instruments as a tangible link between past and present practices in the sciences. We less often integrate instruments into our research and pedagogy, considering artefact study as the domain of museum specialists. We argue here that scholars and…

  5. Musical instruments from the Mayan culture

    NASA Astrophysics Data System (ADS)

    Rizo, Isabel Elena Romero; Redondo, Jose de Jesus Negrete; Paulin, Pablo Roberto Lizana

    2002-11-01

    This research work presents different kinds of sound generation instruments from the Mayan culture together with the Pablo Castellanos and Arturo Chamorro classification. It has to be noted that most of these musical instruments, whistles and noise generators are lost and some of them can only be seen on codex and museums. (To be presented in Spanish.)

  6. 75 FR 31736 - Modifications of Debt Instruments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... changes the instrument to an instrument or property right that is not debt for Federal income tax purposes... or property right that is not debt for Federal income tax purposes is a significant modification. For... some other property right for Federal income tax purposes. However, any portion of the increased...

  7. Measuring the instrument function of radiometers

    SciTech Connect

    Winston, R.; Littlejohn, R.G.

    1997-12-31

    The instrument function is a function of position and angle, the knowledge of which allows one to compute the response of a radiometer to an incident wave field in any state of coherence. The instrument function of a given radiometer need not be calculated; instead, it may be measured by calibration with incident plane waves.

  8. An Alternative Instrument for Private School Competition

    ERIC Educational Resources Information Center

    Cohen-Zada, D.

    2009-01-01

    Empirical studies estimating the effect of private school competition on student outcomes commonly use the share of Catholics in the local population as an instrument for private school competition. I show that this is not a valid instrument since it is endogenous to private school competition and suggest using instead the local share of Catholics…

  9. Instrument For Simulation Of Piezoelectric Transducers

    NASA Technical Reports Server (NTRS)

    Mcnichol, Randal S.

    1996-01-01

    Electronic instrument designed to simulate dynamic output of integrated-circuit piezoelectric acceleration or pressure transducer. Operates in conjunction with external signal-conditioning circuit, generating square-wave signal of known amplitude for use in calibrating signal-conditioning circuit. Instrument also useful as special-purpose square-wave generator in other applications.

  10. Unmanned Instrument Platform for Undersea Exploration

    NASA Technical Reports Server (NTRS)

    Paine, G.; Hansen, G. R.; Gulizia, R. W.; Paluzzi, P.

    1984-01-01

    Instruments accommodated on moving underwater platform. Towable underwater platform 3.2 meters long, 1.2 meters wide, 1.4 meters high and has mass of about 1,250 kilogram. Platform remotely operated and unmanned. Serves as test bed for development of ocean-measuring instruments and sonars at depths to 20,000 feet.

  11. General specifications covering requirements of aeronautic instruments

    NASA Technical Reports Server (NTRS)

    1917-01-01

    Report includes specifications for the use and production of instruments used in the navigation and operation of aircraft. Specifications are included for the following instruments: barometer or altimeter, compass, air speed meter, inclinometer, drift meter, tachometer, oil gauge, oil pressure gauge, gasoline gauge, gasoline flow indicator, distance indicator, barograph, angle of attack indicator, radiator temperature indicator, gasoline feed system pressure indicator, sextant, airplane director.

  12. 47 CFR 73.558 - Indicating instruments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Noncommercial Educational FM Broadcast Stations § 73.558 Indicating instruments. The requirements for indicating instruments described in § 73.258 are applicable to all educational FM broadcast stations licensed with...

  13. 47 CFR 73.558 - Indicating instruments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Noncommercial Educational FM Broadcast Stations § 73.558 Indicating instruments. The requirements for indicating instruments described in § 73.258 are applicable to all educational FM broadcast stations licensed with...

  14. VELA: A Microprocessor-Based Laboratory Instrument.

    ERIC Educational Resources Information Center

    Lambert, Andrew

    1983-01-01

    Provides a general description of a preprogramed, microprocessor-based laboratory instrument, discussing its use in monitoring: (1) environmental changes; (2) distribution of count rates from a radioactive source, and (3) motion on an air tract. Includes list of the instrument's various capabilities: frequency meter, voltmeter, interval timer, and…

  15. The Treatment Validity of Autism Screening Instruments

    ERIC Educational Resources Information Center

    Livanis, Andrew; Mouzakitis, Angela

    2010-01-01

    Treatment validity is a frequently neglected topic of screening instruments used to identify autism spectrum disorders. Treatment validity, however, should represent an important aspect of these instruments to link the resulting data to the selection of interventions as well as make decisions about treatment length and intensity. Research…

  16. Ethical sourcing of dental instruments and materials.

    PubMed

    Kelly, P T; Bhutta, M

    2010-10-23

    There is evidence that dental instruments and materials are being manufactured in the developing world under poor labour conditions. It is suggested that the level of awareness of the dental team with regard to this is raised and that a culture of greater inquiry into the sourcing of instruments and materials is developed.

  17. A laser tracking dynamic robot metrology instrument

    NASA Technical Reports Server (NTRS)

    Parker, G. A.; Mayer, J. R. R.

    1989-01-01

    Research work over several years has resulted in the development of a laser tracking instrument capable of dynamic 3-D measurements of robot end-effector trajectories. The instrument characteristics and experiments to measure the static and dynamic performance of a robot in an industrial manufacturing environment are described. The use of this technology for space applications is examined.

  18. PORTABLE MULTISPECTRAL IMAGING INSTRUMENT FOR FOOD INDUSTRY

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The objective of this paper is to design and fabricate a hand-held multispectral instrument for real-time contaminant detection. Specifically, the protocol to develop a portable multispectral instrument including optical sensor design, fabrication, calibration, data collection, analysis and algorith...

  19. Instrumentation for the Atmospheric Explorer photoelectron spectrometer

    NASA Technical Reports Server (NTRS)

    Peletier, D. P.

    1973-01-01

    The photoelectron spectrometer (PES) is part of the complements of scientific instruments aboard three NASA Atmosphere Explorer (AE) satellites. The PES measures the energy spectrum, angular distribution, and intensity of electrons in the earth's thermosphere. Measurements of energies between 2 and 500 eV are made at altitudes as low as 130 km. The design, characteristics, and performance of the instrument are described.

  20. Career Ladder Instrumentation: The Tennessee Experience.

    ERIC Educational Resources Information Center

    McLarty, Joyce R.

    The evaluation instruments used in the Tennessee Career Ladder program are described, and their evolution over the first three years of program implementation is traced. The instruments are designed to measure teacher performance and to determine outstanding teachers. They include: the Career Ladder Test of Professional Skills (a multiple-choice…