Science.gov

Sample records for integral transform techniques

  1. Barley Transformation Using Biolistic Techniques

    NASA Astrophysics Data System (ADS)

    Harwood, Wendy A.; Smedley, Mark A.

    Microprojectile bombardment or biolistic techniques have been widely used for cereal transformation. These methods rely on the acceleration of gold particles, coated with plasmid DNA, into plant cells as a method of directly introducing the DNA. The first report of the generation of fertile, transgenic barley plants used biolistic techniques. However, more recently Agrobacterium-mediated transformation has been adopted as the method of choice for most cereals including barley. Biolistic procedures are still important for some barley transformation applications and also provide transient test systems for the rapid checking of constructs. This chapter describes methods for the transformation of barley using biolistic procedures and also highlights the use of the technology in transient assays.

  2. Transforming traditional Tai Ji Quan techniques into integrative movement therapy-Tai Ji Quan: Moving for Better Balance.

    PubMed

    Li, Fuzhong

    2014-03-01

    Tai Ji Quan, developed as a martial art, has traditionally served multiple purposes, including self-defense, competition/performance, and health promotion. With respect to health, the benefits historically and anecdotally associated with Tai Ji Quan are now being supported by scientific and clinical research, with mounting evidence indicating its potential value in preventing and managing various diseases and improving well-being and quality of life in middle-aged and older adults. The research findings produced to date have both public health significance and clinical relevance. However, because of its roots in the martial arts, transforming traditional Tai Ji Quan movements and training approaches into contemporary therapeutic programs and functional applications is needed to maximize its ultimate utility. This paper addresses this issue by introducing Tai Ji Quan: Moving for Better Balance, a functional therapy that involves the use of Tai Ji Quan principles and Yang-style-based movements to form an innovative, contemporary therapeutic approach that integrates motor, sensory, and cognitive components to improve postural control, gait, and mobility for older adults and those who have neurodegenerative movement impairments. It provides a synergy of traditional and contemporary Tai Ji Quan practice with the ultimate goal of improving balance and gait, enhancing performance of daily functional tasks, and reducing incidence of falls among older adults.

  3. Analytical solution of the advection-diffusion transport equation using a change-of-variable and integral transform technique

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This paper presents a formal exact solution of the linear advection-diffusion transport equation with constant coefficients for both transient and steady-state regimes. A classical mathematical substitution transforms the original advection-diffusion equation into an exclusively diffusive equation. ...

  4. Barley Transformation Using Agrobacterium-Mediated Techniques

    NASA Astrophysics Data System (ADS)

    Harwood, Wendy A.; Bartlett, Joanne G.; Alves, Silvia C.; Perry, Matthew; Smedley, Mark A.; Leyland, Nicola; Snape, John W.

    Methods for the transformation of barley using Agrobacterium-mediated techniques have been available for the past 10 years. Agrobacterium offers a number of advantages over biolistic-mediated techniques in terms of efficiency and the quality of the transformed plants produced. This chapter describes a simple system for the transformation of barley based on the infection of immature embryos with Agrobacterium tumefaciens followed by the selection of transgenic tissue on media containing the antibiotic hygromycin. The method can lead to the production of large numbers of fertile, independent transgenic lines. It is therefore ideal for studies of gene function in a cereal crop system.

  5. Transformational Leadership, Integrity, and Power

    ERIC Educational Resources Information Center

    Harrison, Laura M.

    2011-01-01

    Transformational leadership enjoys widespread appeal among student affairs professionals. National Association of Student Personnel Administrators (NASPA) and American College Personnel Association (ACPA) conferences frequently feature speakers who promote transformational leadership's two primary tenets: (1) change is the central purpose of…

  6. Data integration using color space transforms

    USGS Publications Warehouse

    Feuquay, Jay W.

    1987-01-01

    The demand for increased spatial resolution without sacrificing spectral discrimination can be fulfilled by integration of data from different sensor systems and satellite programs. Data of high spatial resolution are frequently available in panchromatic (black-and-white) form rather than multispectral. Techniques gave been developed to combine the higher resolution panchromatic data with a multispectral data set of lower spatial resolution. The standard method of integration modulates the intensity of the mutispectral with the panchromatic data. A less subjective approach uses an algorithm that describes color in terms of intensity (I), hue (H), and saturation (S). Combinations of high resolution panchromatic data (SPOT panchromatic) and lower resolution multispectral data [Landsat thematic mapper (TM), SPOT XS] have been developed. The SPOT data were acquired on April 3, 1986, and the Landsat TM data were acquired on April 5, 1986. The data sets were registered to each other and the multi-spectral data sets were contrast enhanced. The enhanced multispectral data sets were then transformed from red/green/blue (RGB) color space into IHS space. In each case (TM/SPOT panchromatic and SPOT XS/SPOT panchromatic), the SPOT panchromatic data were remapped on a cumulative histogram percentage basis to match the multispectral "I" data. These remapped SPOT panchromatic data were substituted for the original multispectral "I" and the hybrid IHS data transformed back into RGB space for display. While this technique is experimental and still being refined, the results, to date, indicate that the IHS method will be valuable for generating improved images that effectively present both high resolution spatial digital data and multispectral data.

  7. New four-dimensional integrals by Mellin-Barnes transform

    NASA Astrophysics Data System (ADS)

    Allendes, Pedro; Guerrero, Natanael; Kondrashuk, Igor; Notte Cuello, Eduardo A.

    2010-05-01

    This paper is devoted to the calculation of a special class of integrals by Mellin-Barnes transform. It contains double integrals in the position space in d =4-2ɛ dimensions, where ɛ is parameter of dimensional regularization. These integrals contribute to the effective action of the N =4 supersymmetric Yang-Mills theory. The integrand is a fraction in which the numerator is the logarithm of the ratio of space-time intervals, and the denominator is the product of powers of space-time intervals. According to the method developed in the previous papers, in order to make use of the uniqueness technique for one of two integrations, we shift exponents in powers in the denominator of integrands by some multiples of ɛ. As the next step, the second integration in the position space is done by Mellin-Barnes transform. For normalizing procedure, we reproduce first the known result obtained earlier by Gegenbauer polynomial technique. Then, we make another shift of exponents in powers in the denominator to create the logarithm in the numerator as the derivative with respect to the shift parameter δ. We show that the technique of work with the contour of the integral modified in this way by using Mellin-Barnes transform repeats the technique of work with the contour of the integral without such a modification. In particular, all the operations with a shift of contour of integration over complex variables of twofold Mellin-Barnes transform are the same as before the δ modification of indices, and even the poles of residues coincide. This confirms the observation made in the previous papers that in the position space all the Green's function of N =4 supersymmetric Yang-Mills theory can be expressed in terms of Usyukina-Davydychev functions.

  8. New four-dimensional integrals by Mellin-Barnes transform

    SciTech Connect

    Allendes, Pedro; Guerrero, Natanael; Kondrashuk, Igor; Notte Cuello, Eduardo A.

    2010-05-15

    This paper is devoted to the calculation of a special class of integrals by Mellin-Barnes transform. It contains double integrals in the position space in d=4-2{epsilon} dimensions, where {epsilon} is parameter of dimensional regularization. These integrals contribute to the effective action of the N=4 supersymmetric Yang-Mills theory. The integrand is a fraction in which the numerator is the logarithm of the ratio of space-time intervals, and the denominator is the product of powers of space-time intervals. According to the method developed in the previous papers, in order to make use of the uniqueness technique for one of two integrations, we shift exponents in powers in the denominator of integrands by some multiples of {epsilon}. As the next step, the second integration in the position space is done by Mellin-Barnes transform. For normalizing procedure, we reproduce first the known result obtained earlier by Gegenbauer polynomial technique. Then, we make another shift of exponents in powers in the denominator to create the logarithm in the numerator as the derivative with respect to the shift parameter {delta}. We show that the technique of work with the contour of the integral modified in this way by using Mellin-Barnes transform repeats the technique of work with the contour of the integral without such a modification. In particular, all the operations with a shift of contour of integration over complex variables of twofold Mellin-Barnes transform are the same as before the {delta} modification of indices, and even the poles of residues coincide. This confirms the observation made in the previous papers that in the position space all the Green's function of N=4 supersymmetric Yang-Mills theory can be expressed in terms of Usyukina-Davydychev functions.

  9. Fourier transform and related integral transforms in superspace

    NASA Astrophysics Data System (ADS)

    de Bie, H.

    2008-09-01

    In this paper extensions of the classical Fourier, fractional Fourier and Radon transforms to superspace are studied. Previously, a Fourier transform in superspace was already studied, but with a different kernel. In this work, the fermionic part of the Fourier kernel has a natural symplectic structure, derived using a Clifford analysis approach. Several basic properties of these three transforms are studied. Using suitable generalizations of the Hermite polynomials to superspace (see [H. De Bie, F. Sommen, Hermite and Gegenbauer polynomials in superspace using Clifford analysis, J. Phys. A 40 (2007) 10441-10456]) an eigenfunction basis for the Fourier transform is constructed.

  10. Radon transforms and Gegenbauer-Chebyshev integrals, II; examples

    NASA Astrophysics Data System (ADS)

    Rubin, Boris

    2016-08-01

    We transfer the results of Part I related to the modified support theorem and the kernel description of the hyperplane Radon transform to totally geodesic transforms on the sphere and the hyperbolic space, the spherical slice transform, and the spherical mean transform for spheres through the origin. The assumptions for functions are formulated in integral terms and close to minimal.

  11. Advanced Techniques for Fourier Transform Wavefront Reconstruction

    SciTech Connect

    Poyneer, L A

    2002-08-05

    The performance of Fourier transform (FT) reconstructors in large adaptive optics systems with Shack-Hartmann sensors and a deformable mirror is analyzed. FT methods, which are derived for point-based geometries, are adapted for use on the continuous systems. Analysis and simulation show how to compensate for effects such as misalignment of the deformable mirror and wavefront sensor gain. Further filtering methods to reduce noise and improve performance are presented. All these modifications can be implemented at the filtering stage, preserving the speed of FT reconstruction. Simulation of a large system shows how compensated FT methods can have equivalent or better performance to slower vector-matrix-multiply reconstructions.

  12. Linear integral transformations and hierarchies of integrable nonlinear evolution equations

    NASA Astrophysics Data System (ADS)

    Nijhoff, Frank W.

    1988-07-01

    Integrable hierarchies of nonlinear evolution equations are investigated on the basis of linear integral equations. These are (Riemann-Hilbert type of) integral transformations which leave invariant an infinite sequence of ordinary differential matrix equations of increasing order in an (indefinite) parameter k. The potential matrices in these equations obey a set of nonlinear recursion relations, leading to a heirarchy of nonlinear partial differential equations. In decreasing order the same equations give rise to a “reciprocal” hierarchy, associated with Heisenberg ferromagnet type of equations. Central in the treatment is an embedding of the hierarchy into an infinite-matrix structure, which is constructed on the basis of the integral equations. In terms of this infinite-matrix structure the equations governing the hierarchies become quite simple. Furthermore, it leads in a straightforward way to various generalizations, such as to other types of linear spectral problems, multicomponent system and lattice equations. Generalizations to equations associated with noncommuting flows follow as a direct consequence of the treatment. Finally, some results on conserved densities and the Hamiltonian structure are briefly discussed.

  13. Teaching Integrative Thought: Techniques and Data.

    ERIC Educational Resources Information Center

    Malloy, Thomas E.

    Focusing on techniques for teaching students to integrate diverse ideas at a deep level of cognitive processing, a study evaluated an idea integration package for teaching writing in the college classroom. Subjects, 29 college students from an introductory psychology class at a Utah university, were divided into two groups. The integration group…

  14. Modelling skin penetration using the Laplace transform technique.

    PubMed

    Anissimov, Y G; Watkinson, A

    2013-01-01

    The Laplace transform is a convenient mathematical tool for solving ordinary and partial differential equations. The application of this technique to problems arising in drug penetration through the skin is reviewed in this paper.

  15. Fourier transform techniques for the inference of cloud motion

    NASA Technical Reports Server (NTRS)

    Lo, R. C.; Rosenfeld, A.

    1974-01-01

    The development and evaluation are reported of phase shift techniques based on the Fourier transform for the estimation of cloud motion from geosynchronous meteorological satellite photographs. An alternative approach to cloud motion estimation, involving thresholding, was proposed and studied.

  16. Techniques for integrating ‐omics data

    PubMed Central

    Akula, Siva Prasad; Miriyala, Raghava Naidu; Thota, Hanuman; Rao, Allam Appa; Gedela, Srinubabu

    2009-01-01

    The challenge for -omics research is to tackle the problem of fragmentation of knowledge by integrating several sources of heterogeneous information into a coherent entity. It is widely recognized that successful data integration is one of the keys to improve productivity for stored data. Through proper data integration tools and algorithms, researchers may correlate relationships that enable them to make better and faster decisions. The need for data integration is essential for present ‐omics community, because ‐omics data is currently spread world wide in wide variety of formats. These formats can be integrated and migrated across platforms through different techniques and one of the important techniques often used is XML. XML is used to provide a document markup language that is easier to learn, retrieve, store and transmit. It is semantically richer than HTML. Here, we describe bio warehousing, database federation, controlled vocabularies and highlighting the XML application to store, migrate and validate -omics data. PMID:19255651

  17. The general 2-D moments via integral transform method for acoustic radiation and scattering

    NASA Astrophysics Data System (ADS)

    Smith, Jerry R.; Mirotznik, Mark S.

    2001-05-01

    The moments via integral transform method (MITM) is a technique to analytically reduce the 2-D method of moments (MoM) impedance double integrals into single integrals. By using a special integral representation of the Green's function, the impedance integral can be analytically simplified to a single integral in terms of transformed shape and weight functions. The reduced expression requires fewer computations and reduces the fill times of the MoM impedance matrix. Furthermore, the resulting integral is analytic for nearly arbitrary shape and weight function sets. The MITM technique is developed for mixed boundary conditions and predictions with basic shape and weight function sets are presented. Comparisons of accuracy and speed between MITM and brute force are presented. [Work sponsored by ONR and NSWCCD ILIR Board.

  18. Radon transforms and Gegenbauer-Chebyshev integrals, I

    NASA Astrophysics Data System (ADS)

    Rubin, Boris

    2016-04-01

    We suggest new modifications of the Helgason's support theorem and description of the kernel for the hyperplane Radon transform and its dual. The assumptions for functions are formulated in integral terms and close to minimal. The proofs rely on the properties of the Gegenbauer-Chebyshev integrals which generalize Abel type fractional integrals on the positive half-line.

  19. Improving Maladaptive Behaviors Using Sensory Integration Techniques.

    ERIC Educational Resources Information Center

    Shuman, Theresa

    A study examined the use of sensory integration techniques to reduce the maladaptive behaviors that interfered with the learning of nine high school students with mental impairments attending a special school. Maladaptive behaviors identified included rocking, toe walking, echolalia, resistance to change, compulsive behaviors, aggression,…

  20. A Transformative Approach to Work Integrated Learning in Legal Education

    ERIC Educational Resources Information Center

    Babacan, Alperhan; Babacan, Hurriyet

    2015-01-01

    Purpose: The purpose of this paper is to discuss the current context, scope and problems in the provision of work-integrated learning (WIL) in legal education and how the adoption transformative pedagogies in WIL which is offered in legal education can foster personal and social transformation in addition to enhancing lawyering skills. The paper…

  1. New real time needle segmentation technique using grayscale Hough transformation

    NASA Astrophysics Data System (ADS)

    Qiu, Wu; Zhou, Hua; Ding, Mingyue; Zhang, Songgeng

    2007-12-01

    Real-time needle segmentation and tracking is very important in image-guided surgery, biopsy, and therapy. In this paper, we described an automated technique to provide real-time needle segmentation from a sequence of 2-D ultrasound images for the use of guidance of a needle to the target in soft tissues. The Hough transform is used to find straight lines or analytic curves in binary image. Hough transform is applied usually to binary images. Hence one needs to convert, initially, the gray level image to a binary one (through thresholding, edge detection, or thinning) in order to apply the HT. While in the process of binarization, some information about line segments in the image may be lost when an inappropriate threshold is used. Gray-Scale Hough Transform can detect the line without binarization. Unfortunately, its high computational cost often prevents it from being applied in real-time applications without the help of specially designed hardware. In this paper, we proposed a needle segmentation technique based on a real-time gray-scale Hough transform. It is composed of an improved Gray Hough Transformation and a coarse-fine search strategy. Furthermore, the RTGHT (Real-Time Gray-Scale Hough Transform) technique is evaluated by patient breast biopsy images. Experiments with patient breast biopsy ultrasound (US) image sequences showed that our approach can segment the biopsy needle in real time (i.e., less than 60 ms) with the angular rms error of about 1° and the position rms error of about 0.5 mm an affordable PC computer without the help of specially designed hardware.

  2. A New Integral Transform for Solving Physical Problems

    NASA Astrophysics Data System (ADS)

    Vastola, John; Efthimiou, Costas

    2015-04-01

    Finding a good integral representation of the reciprocal gamma function is a problem that arises naturally from a certain method of evaluating infinite sums. After finding one representation, and observing that its form is suggestive of an integral transform, we naively define one, and go on to explore its properties. While our transform as we initially define it turns out to be problematic, we demonstrate how to redefine it so that important properties (reminiscent of the Laplace and Fourier transforms) are preserved. Of particular interest is that we may transform any entire function, and that the values of the transform at the nonnegative integers correspond to the function's Taylor coefficients. We may also transform large classes of continuous and meromorphic functions. Interestingly, the aforementioned relationship between a function's transform and a function's Taylor series can be exploited to calculate analytic ``approximations'' to transformable functions. Other topics, like defining the transform for real and complex arguments, and the geometry of transformed functions, are considered. Applications to ordinary and partial differential equations, and related physical problems (from classical mechanics, electrodynamics, and quantum mechanics, among others) are discussed.

  3. Integrated nuclear techniques to detect illicit materials

    SciTech Connect

    DeVolpi, A.

    1997-10-01

    This paper discusses the problem of detecting explosives in the context of an object being transported for illicit purposes. The author emphasizes that technologies developed for this particular application have payoffs in many related problem areas. The author discusses nuclear techniques which can be applied to this detection problem. These include: x-ray imaging; neutronic interrogation; inelastic neutron scattering; fieldable neutron generators. He discusses work which has been done on the applications of these technologies, including results for detection of narcotics. He also discusses efforts to integrate these techniques into complementary systems which offer improved performance.

  4. Fibre based integral field unit constructional techniques

    NASA Astrophysics Data System (ADS)

    Murray, Graham J.

    2006-06-01

    Presented here is a selected overview of constructional techniques and principles that have been developed and implemented at the University of Durham in the manufacture of successful fibre-based integral field units. The information contained herein is specifically intended to highlight the constructional methods that have been devised to assemble an efficient fibre bundle. Potential pitfalls that need to be considered when embarking upon such a deceptively simple instrument are also discussed.

  5. Fourier transform approach in modulation technique of experimental measurements.

    PubMed

    Khazimullin, M V; Lebedev, Yu A

    2010-04-01

    An application of Fourier transform approach in modulation technique of experimental studies is considered. This method has obvious advantages compared with traditional lock-in amplifiers technique--simple experimental setup, a quickly available information on all the required harmonics, high speed of data processing using fast Fourier transform algorithm. A computationally simple, fast and accurate Fourier coefficients interpolation (FCI) method has been implemented to obtain a useful information from harmonics of a multimode signal. Our analysis shows that in this case FCI method has a systematical error (bias) of a signal parameters estimation, which became essential for the short data sets. Hence, a new differential Fourier coefficients interpolation (DFCI) method has been suggested, which is less sensitive to a presence of several modes in a signal. The analysis has been confirmed by simulations and measurements of a quartz wedge birefringence by means of the photoelastic modulator. The obtained bias, noise level, and measuring speed are comparable and even better than in lock-in amplifier technique. Moreover, presented DFCI method is expected to be promised candidate for using in actively developing imaging systems based on the modulation technique requiring fast digital signal processing of large data sets.

  6. Optimization techniques for integrating spatial data

    USGS Publications Warehouse

    Herzfeld, U.C.; Merriam, D.F.

    1995-01-01

    Two optimization techniques ta predict a spatial variable from any number of related spatial variables are presented. The applicability of the two different methods for petroleum-resource assessment is tested in a mature oil province of the Midcontinent (USA). The information on petroleum productivity, usually not directly accessible, is related indirectly to geological, geophysical, petrographical, and other observable data. This paper presents two approaches based on construction of a multivariate spatial model from the available data to determine a relationship for prediction. In the first approach, the variables are combined into a spatial model by an algebraic map-comparison/integration technique. Optimal weights for the map comparison function are determined by the Nelder-Mead downhill simplex algorithm in multidimensions. Geologic knowledge is necessary to provide a first guess of weights to start the automatization, because the solution is not unique. In the second approach, active set optimization for linear prediction of the target under positivity constraints is applied. Here, the procedure seems to select one variable from each data type (structure, isopachous, and petrophysical) eliminating data redundancy. Automating the determination of optimum combinations of different variables by applying optimization techniques is a valuable extension of the algebraic map-comparison/integration approach to analyzing spatial data. Because of the capability of handling multivariate data sets and partial retention of geographical information, the approaches can be useful in mineral-resource exploration. ?? 1995 International Association for Mathematical Geology.

  7. DNA transformations of Candida tropicalis with replicating and integrative vectors.

    PubMed

    Sanglard, D; Fiechter, A

    1992-12-01

    The alkane-assimilating yeast Candida tropicalis was used as a host for DNA transformations. A stable ade2 mutant (Ha900) obtained by UV-mutagenesis was used as a recipient for different vectors carrying selectable markers. A first vector, pMK16, that was developed for the transformation of C. albicans and carries an ADE2 gene marker and a Candida autonomously replicating sequence (CARS) element promoting autonomous replication, was compatible for transforming Ha900. Two transformant types were observed: (i) pink transformants which easily lose pMK16 under non-selective growth conditions; (ii) white transformants, in which the same plasmid exhibited a higher mitotic stability. In both cases pMK16 could be rescued from these cells in Escherichia coli. A second vector, pADE2, containing the isolated C. tropicalis ADE2, gene, was used to transform Ha900. This vector integrated in the yeast genome at homologous sites of the ade2 locus. Different integration types were observed at one or both ade2 alleles in single or in tandem repeats.

  8. DNA transformations of Candida tropicalis with replicating and integrative vectors.

    PubMed

    Sanglard, D; Fiechter, A

    1992-12-01

    The alkane-assimilating yeast Candida tropicalis was used as a host for DNA transformations. A stable ade2 mutant (Ha900) obtained by UV-mutagenesis was used as a recipient for different vectors carrying selectable markers. A first vector, pMK16, that was developed for the transformation of C. albicans and carries an ADE2 gene marker and a Candida autonomously replicating sequence (CARS) element promoting autonomous replication, was compatible for transforming Ha900. Two transformant types were observed: (i) pink transformants which easily lose pMK16 under non-selective growth conditions; (ii) white transformants, in which the same plasmid exhibited a higher mitotic stability. In both cases pMK16 could be rescued from these cells in Escherichia coli. A second vector, pADE2, containing the isolated C. tropicalis ADE2, gene, was used to transform Ha900. This vector integrated in the yeast genome at homologous sites of the ade2 locus. Different integration types were observed at one or both ade2 alleles in single or in tandem repeats. PMID:1293885

  9. A dynamic integrated fault diagnosis method for power transformers.

    PubMed

    Gao, Wensheng; Bai, Cuifen; Liu, Tong

    2015-01-01

    In order to diagnose transformer fault efficiently and accurately, a dynamic integrated fault diagnosis method based on Bayesian network is proposed in this paper. First, an integrated fault diagnosis model is established based on the causal relationship among abnormal working conditions, failure modes, and failure symptoms of transformers, aimed at obtaining the most possible failure mode. And then considering the evidence input into the diagnosis model is gradually acquired and the fault diagnosis process in reality is multistep, a dynamic fault diagnosis mechanism is proposed based on the integrated fault diagnosis model. Different from the existing one-step diagnosis mechanism, it includes a multistep evidence-selection process, which gives the most effective diagnostic test to be performed in next step. Therefore, it can reduce unnecessary diagnostic tests and improve the accuracy and efficiency of diagnosis. Finally, the dynamic integrated fault diagnosis method is applied to actual cases, and the validity of this method is verified.

  10. A Dynamic Integrated Fault Diagnosis Method for Power Transformers

    PubMed Central

    Gao, Wensheng; Liu, Tong

    2015-01-01

    In order to diagnose transformer fault efficiently and accurately, a dynamic integrated fault diagnosis method based on Bayesian network is proposed in this paper. First, an integrated fault diagnosis model is established based on the causal relationship among abnormal working conditions, failure modes, and failure symptoms of transformers, aimed at obtaining the most possible failure mode. And then considering the evidence input into the diagnosis model is gradually acquired and the fault diagnosis process in reality is multistep, a dynamic fault diagnosis mechanism is proposed based on the integrated fault diagnosis model. Different from the existing one-step diagnosis mechanism, it includes a multistep evidence-selection process, which gives the most effective diagnostic test to be performed in next step. Therefore, it can reduce unnecessary diagnostic tests and improve the accuracy and efficiency of diagnosis. Finally, the dynamic integrated fault diagnosis method is applied to actual cases, and the validity of this method is verified. PMID:25685841

  11. Alternative Shapes and Shaping Techniques for Enhanced Transformer Ratios in Beam Driven Techniques

    SciTech Connect

    Lemery, F.; Piot, P.

    2014-01-01

    The transformer ration of collinear beam-driven techniques can be significantly improved by shaping the current profile of the drive bunch. To date, several current shapes have been proposed to increase the transformer ratio and produce quasi-uniform energy loss within the drive bunch. Some of these tailoring techniques are possible as a results of recent beam-dynamics advances, e.g., transverse-to-longitudinal emittance exchanger. In ths paper, we propose an alternative class of longitudinal shapes that enable high transformer ratio and uniform energy loss across the drive bunch. We also suggest a simple method based on photocathode-laser shaping and passive shaping in wakefield structure to realize shape close to the theoretically optimized current profiles.

  12. Path Integrals, Fourier Transforms, and Feynman's Operational Calculus

    SciTech Connect

    Ahn, Byung Moo; Johnson, G. W.

    1998-03-15

    The disentangling process is the key to Feynman's operational calculus for noncommuting operators. The main result of his heuristic calculations deals with disentangling an exponential factor. We use the Wiener and Feynman integrals to make this disentangling (or time-ordering) mathematically rigorous in the case where the analytic functions from earlier work are replaced by Fourier transforms of complex-valued measures.

  13. Transforming the Economics Curriculum by Integrating Threshold Concepts

    ERIC Educational Resources Information Center

    Karunaratne, Prashan Shayanka Mendis; Breyer, Yvonne A.; Wood, Leigh N.

    2016-01-01

    Purpose: Economics is catering to a diverse student cohort. This cohort needs to be equipped with transformative concepts that students can integrate beyond university. When a curriculum is content-driven, threshold concepts are a useful tool in guiding curriculum re-design. The paper aims to discuss these issues. Design/Methodology/Approach: The…

  14. The Effects of Integrated Transformational Leadership on Achievement

    ERIC Educational Resources Information Center

    Boberg, John Eric; Bourgeois, Steven J.

    2016-01-01

    Purpose: Greater understanding about how variables mediate the relationship between leadership and achievement is essential to the success of reform efforts that hold leaders accountable for student learning. The purpose of this paper is to test a model of integrated transformational leadership including three important school mediators.…

  15. Exploring Conditions for Transformative Learning in Work-Integrated Education

    ERIC Educational Resources Information Center

    McRae, Norah

    2015-01-01

    A qualitative study was undertaken that explored the conditions for transformative learning in cooperative education as a form of work-integrated learning (WIL), towards the development of a theoretical model. Four case studies were analyzed based on interviews with WIL students, supervisors and their co-op coordinator. The findings revealed that…

  16. Integral Equation Technique for the Simulation of Signal Integrity and Power Integrity

    NASA Astrophysics Data System (ADS)

    Wei, Xing-Chang; Yang, De-Cao; Li, Er-Ping

    2011-09-01

    Signal integrity and power integrity are the critical issues for high-speed digital circuits. This paper reviews the state-of-the-arts of the integral equation technique used for the simulation of signal integrity and power integrity including the power and ground planes. According to the different circuit boundary conditions, the applied integral equation methods can be classified into mode method/segment method, image method, and equivalent electromagnetic currents method. The mode/segment and image method is used for power and ground planes with rectangular shapes, while the equivalent electromagnetic currents method is efficient for power and ground planes with arbitrary shapes. The most important part of these integral equations is the integral kernels (Green's functions). The integral kernels are derived for different circuit boundaries. Both the theoretical formula and simulation results are present, which are then verified with other available simulation methods and measurement results.

  17. Classical integrable defects as quasi Bäcklund transformations

    NASA Astrophysics Data System (ADS)

    Doikou, Anastasia

    2016-10-01

    We consider the algebraic setting of classical defects in discrete and continuous integrable theories. We derive the "equations of motion" on the defect point via the space-like and time-like description. We then exploit the structural similarity of these equations with the discrete and continuous Bäcklund transformations. And although these equations are similar they are not exactly the same to the Bäcklund transformations. We also consider specific examples of integrable models to demonstrate our construction, i.e. the Toda chain and the sine-Gordon model. The equations of the time (space) evolution of the defect (discontinuity) degrees of freedom for these models are explicitly derived.

  18. Prediction of Landslide using Integration Technique

    NASA Astrophysics Data System (ADS)

    Saro, Lee; Hyun-Joo, Oh

    2010-05-01

    Integrated techniques were developed, applied, and verified for analysis of landslide susceptibility in Jinbu-myeon, Korea using a Geographic Information System (GIS). Landslide locations were identified in the Jinbu-myeon area from interpretation of digital aerial photographs and field surveys. The topographic, soil, forest, geologic, lineament and land cover data were collected, processed and constructed into a spatial database using GIS data. The factors that influence landslide occurrence, such as slope, aspect, curvature, Topographic Wetness Index (TWI), and Stream Power Index (SPI) of the topography, were calculated from the topographic database. Texture, material, drainage, effective soil thickness and topographic were extracted from the soil database, and type, age, diameter and density of timber were extracted form the forest database. The lithology was extracted from the geological database and lineaments were detected from hillshade map. The structural geologist interpreted the hillshade map and detected the lineaments. The land cover was classified based on the SPOT satellite image. By using the constructed spatial database, the relationships between the detected landslide locations and the seventeen related factors were identified and quantified by likelihood ratio, weight of evidence, logistic regression and artificial neural networks models. The relationships were used as factor ratings in the overlay analysis to create landslide susceptibility indexes and maps. Then the four landslide susceptibility maps were reflected in new input factors and combined using likelihood ratio, weight of evidence, logistic regression and artificial neural network models to make better susceptibility map. All of the susceptibility maps were verified by comparison with known landslide locations, which were not used during the training of the individual models. As the result, the combined landslide susceptibility maps used landslide-related new four input factors showed

  19. Improved technique for one-way transformation of information

    DOEpatents

    Cooper, J.A.

    1987-05-11

    Method and apparatus are provided for one-way transformation of data according to multiplication and/or exponentiation modulo a prime number. An implementation of the invention permits the one way residue transformation, useful in encryption and similar applications, to be implemented by n-bit computers substantially with no increase in difficulty or complexity over a natural transformation thereby, using a modulus which is a power of two. 9 figs.

  20. Assessment of simple marker-free genetic transformation techniques in alfalfa.

    PubMed

    Ferradini, Nicoletta; Nicolia, Alessandro; Capomaccio, Stefano; Veronesi, Fabio; Rosellini, Daniele

    2011-11-01

    Methods to avoid the presence of selectable marker genes (SMG) in transgenic plants are available but not implemented in many crop species. We assessed the efficiency of simple marker-free Agrobacterium-mediated transformation techniques in alfalfa: regeneration without selection, or marker-less, and co-transformation with two vectors, one containing the SMG and one containing a non-selected gene. To easily estimate the efficiency of marker-less transformation, the nptII and the GUS markers were used as non-selected genes. After Agrobacterium treatment, somatic embryos were regenerated without selection. The percentage of transgenic embryos was determined by a second cycle of regeneration using the embryos as starting material, in the presence of kanamycin, by PCR screening of T1 progenies, and by the GUS test. In two experiments, from 0 to 1.7% of the somatic embryos were transgenic. Co-transformation was performed with two vectors, one with the hemL SMG and one with the unselected nptII gene, each carried by a different culture of Agrobacterium. Only 15 putative co-transformed plants were regenerated from two experiments, with an average co-transformation percentage of 3.7. Southern blot hybridizations and/or T(1) progeny segregation were used to confirm transgene integration, and qPCR was also used to estimate the T-DNA copy number. In the T(1) progenies obtained by crossing with a non-transgenic pollinator, marker-free segregants were obtained. Both marker-free approaches showed very low efficiency. PMID:21691741

  1. Non-parametric transformation for data correlation and integration: From theory to practice

    SciTech Connect

    Datta-Gupta, A.; Xue, Guoping; Lee, Sang Heon

    1997-08-01

    The purpose of this paper is two-fold. First, we introduce the use of non-parametric transformations for correlating petrophysical data during reservoir characterization. Such transformations are completely data driven and do not require a priori functional relationship between response and predictor variables which is the case with traditional multiple regression. The transformations are very general, computationally efficient and can easily handle mixed data types for example, continuous variables such as porosity, permeability and categorical variables such as rock type, lithofacies. The power of the non-parametric transformation techniques for data correlation has been illustrated through synthetic and field examples. Second, we utilize these transformations to propose a two-stage approach for data integration during heterogeneity characterization. The principal advantages of our approach over traditional cokriging or cosimulation methods are: (1) it does not require a linear relationship between primary and secondary data, (2) it exploits the secondary information to its fullest potential by maximizing the correlation between the primary and secondary data, (3) it can be easily applied to cases where several types of secondary or soft data are involved, and (4) it significantly reduces variance function calculations and thus, greatly facilitates non-Gaussian cosimulation. We demonstrate the data integration procedure using synthetic and field examples. The field example involves estimation of pore-footage distribution using well data and multiple seismic attributes.

  2. Project management techniques for highly integrated programs

    NASA Technical Reports Server (NTRS)

    Stewart, J. F.; Bauer, C. A.

    1983-01-01

    The management and control of a representative, highly integrated high-technology project, in the X-29A aircraft flight test project is addressed. The X-29A research aircraft required the development and integration of eight distinct technologies in one aircraft. The project management system developed for the X-29A flight test program focuses on the dynamic interactions and the the intercommunication among components of the system. The insights gained from the new conceptual framework permitted subordination of departments to more functional units of decisionmaking, information processing, and communication networks. These processes were used to develop a project management system for the X-29A around the information flows that minimized the effects inherent in sampled-data systems and exploited the closed-loop multivariable nature of highly integrated projects.

  3. Blind data hiding technique using the Fresnelet transform.

    PubMed

    Muhammad, Nazeer; Bibi, Nargis; Mahmood, Zahid; Kim, Dai-Gyoung

    2015-01-01

    A new blind data hiding scheme is proposed in which data is decomposed using the Fresnelet transform. The inverse Fresnelet transform is performed on decomposed subbands by choosing different key parameters, and the coded pattern of the information data is obtained. This coded pattern is embedded into particular subbands of the cover image using the wavelets. The proposed method has good imperceptibility and large capacity of the information embedded data. Using the Fresnelet transform with a family of wavelet transforms makes the scheme more efficient in terms of extracted accuracy of hidden information. Moreover, the hidden data can be recovered without access to the original cover data. The proposed method is used to resolve privacy and security issues raised with respect to emerging internet applications for the effective handling of confidential data. PMID:26753119

  4. Embedded wavelet packet transform technique for texture compression

    NASA Astrophysics Data System (ADS)

    Li, Jin; Cheng, Po-Yuen; Kuo, C.-C. Jay

    1995-09-01

    A highly efficient texture compression scheme is proposed in this research. With this scheme, energy compaction of texture images is first achieved by the wavelet packet transform, and an embedding approach is then adopted for the coding of the wavelet packet transform coefficients. By comparing the proposed algorithm with the JPEG standard, FBI wavelet/scalar quantization standard and the EZW scheme with extensive experimental results, we observe a significant improvement in the rate-distortion performance and visual quality.

  5. Feasibility investigation of integrated optics Fourier transform devices. [holographic subtraction for multichannel data preprocessing

    NASA Technical Reports Server (NTRS)

    Verber, C. M.; Vahey, D. W.; Wood, V. E.; Kenan, R. P.; Hartman, N. F.

    1977-01-01

    The possibility of producing an integrated optics data processing device based upon Fourier transformations or other parallel processing techniques, and the ways in which such techniques may be used to upgrade the performance of present and projected NASA systems were investigated. Activities toward this goal include; (1) production of near-diffraction-limited geodesic lenses in glass waveguides; (2) development of grinding and polishing techniques for the production of geodesic lenses in LiNbO3 waveguides; (3) development of a characterization technique for waveguide lenses; and (4) development of a theory for corrected aspheric geodesic lenses. A holographic subtraction system was devised which should be capable of rapid on-board preprocessing of a large number of parallel data channels. The principle involved is validated in three demonstrations.

  6. Preliminary Component Integration Using Rapid Prototyping Techniques

    NASA Technical Reports Server (NTRS)

    Cooper, Ken; Salvail, Pat; Gordon, Gail (Technical Monitor)

    2001-01-01

    Rapid prototyping is a very important tool that should be used by both design and manufacturing disciplines during the development of elements for the aerospace industry. It helps prevent lack of adequate communication between design and manufacturing engineers (which could lead to costly errors) through mutual consideration of functional models generated from drawings. Rapid prototyping techniques are used to test hardware for design and material compatibility at Marshall Space Flight Center.

  7. Resolution of resonances with the Lorentz integral transform

    NASA Astrophysics Data System (ADS)

    Leidemann, Winfried

    2016-03-01

    The energy resolution of cross sections calculated with the Lorentz integral transform (LIT) method is investigated. It is shown that a crucial role is played by the density of LIT states obtained in the calculation. The situation is illustrated for the simple case of deuteron photodisintegration in unretarded dipole approximation. In a next step the 4He isoscalar monopole resonance is considered. It is pointed out that in a specific energy interval the density of LIT states may depend on the A-body basis chosen for the solution of the LIT equation. Using a central NN potential and choosing a proper A-body basis set it is shown that the width of the 4He isoscalar monopole resonance can be determined. A value of 180(70) keV is obtained, which is close to the experimental value of 270(50) keV.

  8. "Agrolistic" transformation of plant cells: integration of T-strands generated in planta.

    PubMed

    Hansen, G; Chilton, M D

    1996-12-10

    We describe a novel plant transformation technique, termed "agrolistic," that combines the advantages of the Agrobacterium transformation system with the high efficiency of biolistic DNA delivery. Agrolistic transformation allows integration of the gene of interest without undesired vector sequence. The virulence genes virD1 and virD2 from Agrobacterium tumefaciens that are required in bacteria for excision of T-strands from the tumor-inducing plasmid were placed under the control of the CaMV35S promoter and codelivered with a target plasmid containing border sequences flanking the gene of interest. Transient expression assays in tobacco and in maize cells indicated that vir gene products caused strand-specific nicking in planta at the right border sequence, similar to VirD1/VirD2-catalyzed T-strand excision observed in Agrobacterium. Agrolistically transformed tobacco calli were obtained after codelivery of virD1 and virD2 genes together with a selectable marker flanked by border sequences. Some inserts exhibited right junctions with plant DNA that corresponded precisely to the sequence expected for T-DNA (portion of the tumor-inducing plasmid that is transferred to plant cells) insertion events. We designate these as "agrolistic" inserts, as distinguished from "biolistic" inserts. Both types of inserts were found in some transformed lines. The frequency of agrolistic inserts was 20% that of biolistic inserts. PMID:8962167

  9. Distance functions in dynamic integration of data mining techniques

    NASA Astrophysics Data System (ADS)

    Puuronen, Seppo J.; Tsymbal, Alexey; Terziyan, Vagan

    2000-04-01

    One of the most important directions in the improvement of data mining and knowledge discovery is the integration of multiple data mining techniques. An integration method needs to be able either to evaluate and select the most appropriate data mining technique or to combine two or more techniques efficiently. A recent integration method for the dynamic integration of multiple data mining techniques is based on the assumption that each of the data mining techniques is the best one inside a certain subarea of the whole domain area. This method uses an instance-based learning approach to collect information about the competence areas of the mining techniques and applies a distance function to determine how close a new instance is to each instance of the training set. The nearest instance or instances are used to predict the performance of the data mining techniques. Because the quality of the integration depends heavily on the suitability of the used distance function, our goal is to analyze the characteristics of different distance functions. In this paper we investigate several distance functions as the very commonly used Euclidean distance function, the Heterogeneous Euclidean- Overlap Metric (HEOM), and the Heterogeneous Value Difference Metric (HVDM), among others. We analyze the effects of the use of different distance functions to the accuracy achieved by dynamic integration when the parameters describing datasets vary. We include also results of our experiments with different datasets which include both nominal and continuous attributes.

  10. Improved integral imaging based image copyright protection algorithm using 3-D computational integral imaging pickup and super-resolution reconstruction technique

    NASA Astrophysics Data System (ADS)

    Li, Xiao Wei; Lee, In-Kwon; Kim, Seok Tae

    2014-11-01

    Cellular automata transform (CAT) based watermarking method can provide multi-transform planes for embedding watermark. In this paper, to overcome conventional transform-based watermarking methods have only one transform plane for watermark embedding, we propose a CAT-based watermarking system, in which the three-dimensional (3-D) watermark data is decomposed by the computational integral imaging (CII) technique and be embedded into the CAT domain. However, in the 3-D watermark reconstruction process, the computational integral imaging reconstruction (CIIR) technique in CII system that can degrade the quality of the extracted watermark due to the pixel overlapping. We introduce the super-resolution reconstruction technique that can effectively improve this problem. Some experiments are carried out to verify the performance of the CAT-based watermarking scheme. From the experimental results, the proposed watermarking system can provide good imperceptibility and high robustness.

  11. Comparing Parameter Estimation Techniques for an Electrical Power Transformer Oil Temperature Prediction Model

    NASA Technical Reports Server (NTRS)

    Morris, A. Terry

    1999-01-01

    This paper examines various sources of error in MIT's improved top oil temperature rise over ambient temperature model and estimation process. The sources of error are the current parameter estimation technique, quantization noise, and post-processing of the transformer data. Results from this paper will show that an output error parameter estimation technique should be selected to replace the current least squares estimation technique. The output error technique obtained accurate predictions of transformer behavior, revealed the best error covariance, obtained consistent parameter estimates, and provided for valid and sensible parameters. This paper will also show that the output error technique should be used to minimize errors attributed to post-processing (decimation) of the transformer data. Models used in this paper are validated using data from a large transformer in service.

  12. The multi-spacer patterning technique: a non-lithographic technique for terascale integration

    NASA Astrophysics Data System (ADS)

    Cerofolini, G. F.; Amato, P.; Romano, E.

    2008-07-01

    Since the pioneering paper of Aviram and Ratner it has become progressively clearer and clearer that molecules can perform electrical functions so sophisticated as to mimic the behavior of electronic devices, hence the idea of exploiting them for molecular electronics. The practical exploitation of the electronic properties of molecules for computing (i.e., the transformation of a collection of molecules into a device) is, however, a major problem not yet solved. In the last few years the expertise in molecular design and synthesis combined with (i) the identification of a new structure, the crossbar, able to replace those based on a planar arrangement of field effect transistors, and (ii) the development of sub-lithographic techniques for the definition of a random or ordered planar arrangement of nanometre-sized features, has nonetheless led to consider as realistic the hypothesis that molecular devices might replace silicon-based devices when the basic element of the integrated circuit, the metal-oxide-semiconductor field effect transistor, will no longer admit further shrinking. This work is addressed to identify in which ways features (i) and (ii) can be exploited for application in molecular electronics.

  13. Ultrasonic technique for inspection of GPHS capsule girth weld integrity

    SciTech Connect

    Placr, Arnost

    1993-05-01

    An innovative nondestructive examination (NDE) technique for the inspection of integrity of General Purpose Heat Source (GPHS) capsule girth welds (Figure 1) was developed employing a Lamb (plate) wave as the mode of the sound propagation. Reliability of the Lamb wave technique was tested on GPHS capsules using plutonium pallet simulators. All ten capsules, which were previously rejected, passed ultrasonic (UT) inspection using the Lamb wave technique.

  14. Novel integration technique for silicon/III-V hybrid laser.

    PubMed

    Dong, Po; Hu, Ting-Chen; Liow, Tsung-Yang; Chen, Young-Kai; Xie, Chongjin; Luo, Xianshu; Lo, Guo-Qiang; Kopf, Rose; Tate, Alaric

    2014-11-01

    Integrated semiconductor lasers on silicon are one of the most crucial devices to enable low-cost silicon photonic integrated circuits for high-bandwidth optic communications and interconnects. While optical amplifiers and lasers are typically realized in III-V waveguide structures, it is beneficial to have an integration approach which allows flexible and efficient coupling of light between III-V gain media and silicon waveguides. In this paper, we propose and demonstrate a novel fabrication technique and associated transition structure to realize integrated lasers without the constraints of other critical processing parameters such as the starting silicon layer thicknesses. This technique employs epitaxial growth of silicon in a pre-defined trench with taper structures. We fabricate and demonstrate a long-cavity hybrid laser with a narrow linewidth of 130 kHz and an output power of 1.5 mW using the proposed technique. PMID:25401832

  15. Transforming Student Health Services through Purpose-Driven Assessment Techniques

    ERIC Educational Resources Information Center

    Knoll, Dorothy; Meiers, Chris; Honeck, Sara

    2006-01-01

    The University of Kansas Medical Center did a comprehensive review of the services provided in the Student Health Center (SHC). Using purpose-driven assessment techniques, areas needing improvement were identified. The results of the survey were presented to students and, with student support, student health fees were increased to fund desired…

  16. An Operator Method for Evaluating Laplace Transforms

    ERIC Educational Resources Information Center

    Lanoue, B. G.; Yurekli, O.

    2005-01-01

    This note discusses a simple operator technique based on the differentiation and shifting properties of the Laplace transform to find Laplace transforms for various elementary functions. The method is simpler than known integration techniques to evaluate Laplace transforms.

  17. Incipient fault diagnosis of power transformers using optical spectro-photometric technique

    NASA Astrophysics Data System (ADS)

    Hussain, K.; Karmakar, Subrata

    2015-06-01

    Power transformers are the vital equipment in the network of power generation, transmission and distribution. Mineral oil in oil-filled transformers plays very important role as far as electrical insulation for the winding and cooling of the transformer is concerned. As transformers are always under the influence of electrical and thermal stresses, incipient faults like partial discharge, sparking and arcing take place. As a result, mineral oil deteriorates there by premature failure of the transformer occurs causing huge losses in terms of revenue and assets. Therefore, the transformer health condition has to be monitored continuously. The Dissolved Gas Analysis (DGA) is being extensively used for this purpose, but it has some drawbacks like it needs carrier gas, regular instrument calibration, etc. To overcome these drawbacks, Ultraviolet (UV) -Visible and Fourier Transform Infrared (FTIR) Spectro-photometric techniques are used as diagnostic tools for investigating the degraded transformer oil affected by electrical, mechanical and thermal stresses. The technique has several advantages over the conventional DGA technique.

  18. Derivative information recovery by a selective integration technique

    NASA Technical Reports Server (NTRS)

    Johnson, M. A.

    1974-01-01

    A nonlinear stationary homogeneous digital filter DIRSIT (derivative information recovery by a selective integration technique) is investigated. The spectrum of a quasi-linear discrete describing function (DDF) to DIRSIT is obtained by a digital measuring scheme. A finite impulse response (FIR) approximation to the quasi-linearization is then obtained. Finally, DIRSIT is compared with its quasi-linear approximation and with a standard digital differentiating technique. Results indicate the effects of DIRSIT on a wide variety of practical signals.

  19. Examining integrative thinking through the transformation of students' written reflections into concept webs.

    PubMed

    Ziegler, Brittany; Montplaisir, Lisa

    2012-12-01

    A shift is currently taking place in which explicit connections between content are being emphasized. Biology is not an isolated discipline, yet undergraduate courses frequently focus on discrete knowledge. Students often engage in rote learning, struggle with transforming and applying content. Integrative thinking occurs when students recognize connections to content. Written reflections provide students with the opportunity to demonstrate this thinking. We transformed student-written reflections into concept webs to gain insights into how students connect biological concepts. We were interested in determining if characteristics of integrative thinking develop through reflections. The results indicate a significant relationship between concepts and integrated relationships. Integrative thinking varied but declined overall. Concept webs allow for an examination of student integrative thinking through the transformation of reflection and provide insights into the connections and relationships that students draw between biological concepts. Reflections can transform learning by facilitating and allowing for the evaluation of integrative thinking.

  20. Nondestructive Technique Survey for Assessing Integrity of Composite Firing Vessel

    SciTech Connect

    Tran, A.

    2000-08-01

    The repeated use and limited lifetime of a composite tiring vessel compel a need to survey techniques for monitoring the structural integrity of the vessel in order to determine when it should be retired. Various nondestructive techniques were researched and evaluated based on their applicability to the vessel. The methods were visual inspection, liquid penetrant testing, magnetic particle testing, surface mounted strain gauges, thermal inspection, acoustic emission, ultrasonic testing, radiography, eddy current testing, and embedded fiber optic sensors. It was determined that embedded fiber optic sensor is the most promising technique due to their ability to be embedded within layers of composites and their immunity to electromagnetic interference.

  1. Transformer Incipient Fault Prediction Using Combined Artificial Neural Network and Various Particle Swarm Optimisation Techniques

    PubMed Central

    2015-01-01

    It is important to predict the incipient fault in transformer oil accurately so that the maintenance of transformer oil can be performed correctly, reducing the cost of maintenance and minimise the error. Dissolved gas analysis (DGA) has been widely used to predict the incipient fault in power transformers. However, sometimes the existing DGA methods yield inaccurate prediction of the incipient fault in transformer oil because each method is only suitable for certain conditions. Many previous works have reported on the use of intelligence methods to predict the transformer faults. However, it is believed that the accuracy of the previously proposed methods can still be improved. Since artificial neural network (ANN) and particle swarm optimisation (PSO) techniques have never been used in the previously reported work, this work proposes a combination of ANN and various PSO techniques to predict the transformer incipient fault. The advantages of PSO are simplicity and easy implementation. The effectiveness of various PSO techniques in combination with ANN is validated by comparison with the results from the actual fault diagnosis, an existing diagnosis method and ANN alone. Comparison of the results from the proposed methods with the previously reported work was also performed to show the improvement of the proposed methods. It was found that the proposed ANN-Evolutionary PSO method yields the highest percentage of correct identification for transformer fault type than the existing diagnosis method and previously reported works. PMID:26103634

  2. Transformer Incipient Fault Prediction Using Combined Artificial Neural Network and Various Particle Swarm Optimisation Techniques.

    PubMed

    Illias, Hazlee Azil; Chai, Xin Rui; Abu Bakar, Ab Halim; Mokhlis, Hazlie

    2015-01-01

    It is important to predict the incipient fault in transformer oil accurately so that the maintenance of transformer oil can be performed correctly, reducing the cost of maintenance and minimise the error. Dissolved gas analysis (DGA) has been widely used to predict the incipient fault in power transformers. However, sometimes the existing DGA methods yield inaccurate prediction of the incipient fault in transformer oil because each method is only suitable for certain conditions. Many previous works have reported on the use of intelligence methods to predict the transformer faults. However, it is believed that the accuracy of the previously proposed methods can still be improved. Since artificial neural network (ANN) and particle swarm optimisation (PSO) techniques have never been used in the previously reported work, this work proposes a combination of ANN and various PSO techniques to predict the transformer incipient fault. The advantages of PSO are simplicity and easy implementation. The effectiveness of various PSO techniques in combination with ANN is validated by comparison with the results from the actual fault diagnosis, an existing diagnosis method and ANN alone. Comparison of the results from the proposed methods with the previously reported work was also performed to show the improvement of the proposed methods. It was found that the proposed ANN-Evolutionary PSO method yields the highest percentage of correct identification for transformer fault type than the existing diagnosis method and previously reported works.

  3. Premethylation of Foreign DNA Improves Integrative Transformation Efficiency in Synechocystis sp. Strain PCC 6803

    PubMed Central

    Wang, Bo; Yu, Jianping

    2015-01-01

    Restriction digestion of foreign DNA is one of the key biological barriers against genetic transformation in microorganisms. To establish a high-efficiency transformation protocol in the model cyanobacterium, Synechocystis sp. strain PCC 6803 (Synechocystis 6803), we investigated the effects of premethylation of foreign DNA on the integrative transformation of this strain. In this study, two type II methyltransferase-encoding genes, i.e., sll0729 (gene M) and slr0214 (gene C), were cloned from the chromosome of Synechocystis 6803 and expressed in Escherichia coli harboring an integration plasmid. After premethylation treatment in E. coli, the integration plasmid was extracted and used for transformation of Synechocystis 6803. The results showed that although expression of methyltransferase M had little impact on the transformation of Synechocystis 6803, expression of methyltransferase C resulted in 11- to 161-fold-higher efficiency in the subsequent integrative transformation of Synechocystis 6803. Effective expression of methyltransferase C, which could be achieved by optimizing the 5′ untranslated region, was critical to efficient premethylation of the donor DNA and thus high transformation efficiency in Synechocystis 6803. Since premethylating foreign DNA prior to transforming Synechocystis avoids changing the host genetic background, the study thus provides an improved method for high-efficiency integrative transformation of Synechocystis 6803. PMID:26452551

  4. Modular packaging technique for combining integrated circuits and discrete components

    NASA Technical Reports Server (NTRS)

    Lacchia, J. F.

    1969-01-01

    Technique for packaging electronic modules interconnects integrated circuits and discrete components by means of beryllium-copper strips in a molded diallyphthalate tray. Simple girder-like construction provides ease of assembly, high rigidity, excellent vibration resistance, and good heat dissipation characteristics.

  5. Integrative Teaching Techniques and Improvement of German Speaking Learning Skills

    ERIC Educational Resources Information Center

    Litualy, Samuel Jusuf

    2016-01-01

    This research ist a Quasi-Experimental research which only applied to one group without comparison group. It aims to prove whether the implementation of integrative teaching technique has influenced the speaking skill of the students in German Education Study Program of FKIP, Pattimura University. The research was held in the German Education…

  6. The Impact of Technology Integration through a Transformative Approach

    ERIC Educational Resources Information Center

    Cubillos, Jo Ann

    2013-01-01

    The integration of technology into classroom instruction in K-12 schools remains problematic. The problems associated with this integration are troubling, as technology integration may change a teacher's pedagogy toward more innovative approaches that increase student achievement. The purpose of this study was to document teachers' experiences as…

  7. A novel technique for an integrated optical wavelength demultiplexer

    NASA Astrophysics Data System (ADS)

    Lotfy Rabeh, M.; Mohanna, M.; Hosny, Tarek; Gabr, Mohamed I.

    2015-12-01

    In this paper we propose a new technique for optical wavelength demultiplexing (DEMUX) relaying on two phenomena: Goos-Haenchen (GH) shift and continuous refraction at a graded-index medium interface. In the first case, two light beams are totally reflected at a plane interface separating two dielectric lossless media. The reflected beams suffer different lateral shifts (GH shifts) depending on the wavelength; thus accomplishing the required spatial beam separation. In the second case, the two light beams have different "turning points" inside the graded index medium; hence, the "back-refracted" beams are spatially separated. In this paper, we optimized the conditions of operation of such demultiplexing technique. This makes possible the integration of such technique in "planar integrated-optics" structures which can be used reliably in optical fiber communication networks.

  8. Multiscale Transient Signal Detection: Localizing Transients in Geodetic Data Through Wavelet Transforms and Sparse Estimation Techniques

    NASA Astrophysics Data System (ADS)

    Riel, B.; Simons, M.; Agram, P.

    2012-12-01

    Transients are a class of deformation signals on the Earth's surface that can be described as non-periodic accumulation of strain in the crust. Over seismically and volcanically active regions, these signals are often challenging to detect due to noise and other modes of deformation. Geodetic datasets that provide precise measurements of surface displacement over wide areas are ideal for exploiting both the spatial and temporal coherence of transient signals. We present an extension to the Multiscale InSAR Time Series (MInTS) approach for analyzing geodetic data by combining the localization benefits of wavelet transforms (localizing signals in space) with sparse optimization techniques (localizing signals in time). Our time parameterization approach allows us to reduce geodetic time series to sparse, compressible signals with very few non-zero coefficients corresponding to transient events. We first demonstrate the temporal transient detection by analyzing GPS data over the Long Valley caldera in California and along the San Andreas fault near Parkfield, CA. For Long Valley, we are able to resolve the documented 2002-2003 uplift event with greater temporal precision. Similarly for Parkfield, we model the postseismic deformation by specific integrated basis splines characterized by timescales that are largely consistent with postseismic relaxation times. We then apply our method to ERS and Envisat InSAR datasets consisting of over 200 interferograms for Long Valley and over 100 interferograms for Parkfield. The wavelet transforms reduce the impact of spatially correlated atmospheric noise common in InSAR data since the wavelet coefficients themselves are essentially uncorrelated. The spatial density and extended temporal coverage of the InSAR data allows us to effectively localize ground deformation events in both space and time with greater precision than has been previously accomplished.

  9. Darboux transformation and exact solutions of the integrable Heisenberg ferromagnetic equation with self-consistent potentials

    NASA Astrophysics Data System (ADS)

    Yersultanova, Z. S.; Zhassybayeva, M.; Yesmakhanova, K.; Nugmanova, G.; Myrzakulov, R.

    2016-10-01

    Integrable Heisenberg ferromagnetic equations are an important subclass of integrable systems. The M-XCIX equation is one of a generalizations of the Heisenberg ferromagnetic equation and are integrable. In this paper, the Darboux transformation of the M-XCIX equation is constructed. Using the DT, a 1-soliton solution of the M-XCIX equation is presented.

  10. Transformative practices for integrating mind-body-spirit.

    PubMed

    Luskin, Frederic

    2004-01-01

    This paper explores the clinical use of transformative practices that arose from the varied religious traditions of the world. Examples include prayer, meditation, mantra, affirmation, tai chi, and yoga. The purpose of these practices was to lead the practitioner to long term spiritual transformation toward an enhanced awareness of spirit, and a corresponding diminishment of identification with the mental and physical aspects of life. Unfortunately, the vagueness of the definition of transformation demonstrates that it is a broad and diffuse multidimensional concept difficult to quantify and resistant to rigorous research. However, these spiritual practices, offered as interventions separate from their spiritual tradition, have begun to be evaluated to document their effect on psychological and physical well-being. Currently, there are a number of well-designed studies that attest to the health-enhancing and suffering-reducing benefits derived from religiously transformative practices. There also is research, although sporadic and mostly on forgiveness, slowly emerging to show that prosocial positive emotion skills can be taught, and when measured, demonstrate benefit. Randomized trials of transformative practices are needed to help all levels of the health care system focus their attention on the manifestations and effect of the care delivered.

  11. Enhanced integral imaging system using image floating technique

    NASA Astrophysics Data System (ADS)

    Min, Sung-Wook; Kim, Joohwan; Lee, Byoungho

    2005-09-01

    Enhanced integral imaging system based on the image floating method is proposed. The integral imaging is one of the most promising methods among the autostereoscopic displays and the integrated image has the volumetric characteristics unlike the other stereoscopic images. The image floating is a common 3D display technique, which uses a big convex lens or a concave mirror to exhibit the image of a real object to the observer. The image floating method can be used to emphasize the viewing characteristics of the volumetric image and the noise image which is located on the fixed plane can be eliminated by the floating lens through the control of the focal length. In this paper, the solution of the seam noise and the image flipping of the integral imaging system is proposed using the image floating method. Moreover, the advanced techniques of the integral imaging system can be directly applied to the proposed system. The proposed system can be successfully applied to many 3D applications such as 3D television.

  12. Darboux transformations with tetrahedral reduction group and related integrable systems

    NASA Astrophysics Data System (ADS)

    Berkeley, George; Mikhailov, Alexander V.; Xenitidis, Pavlos

    2016-09-01

    In this paper, we derive new two-component integrable differential difference and partial difference systems by applying a Lax-Darboux scheme to an operator formed from an 𝔰𝔩3(ℂ)-based automorphic Lie algebra. The integrability of the found systems is demonstrated via Lax pairs and generalised symmetries.

  13. Solution of fractional kinetic equation by a class of integral transform of pathway type

    NASA Astrophysics Data System (ADS)

    Kumar, Dilip

    2013-04-01

    Solutions of fractional kinetic equations are obtained through an integral transform named Pα-transform introduced in this paper. The Pα-transform is a binomial type transform containing many class of transforms including the well known Laplace transform. The paper is motivated by the idea of pathway model introduced by Mathai [Linear Algebra Appl. 396, 317-328 (2005), 10.1016/j.laa.2004.09.022]. The composition of the transform with differential and integral operators are proved along with convolution theorem. As an illustration of applications to the general theory of differential equations, a simple differential equation is solved by the new transform. Being a new transform, the Pα-transform of some elementary functions as well as some generalized special functions such as H-function, G-function, Wright generalized hypergeometric function, generalized hypergeometric function, and Mittag-Leffler function are also obtained. The results for the classical Laplace transform is retrieved by letting α → 1.

  14. Integration of planar transformer and/or planar inductor with power switches in power converter

    DOEpatents

    Chen, Kanghua; Ahmed, Sayeed; Zhu, Lizhi

    2007-10-30

    A power converter integrates at least one planar transformer comprising a multi-layer transformer substrate and/or at least one planar inductor comprising a multi-layer inductor substrate with a number of power semiconductor switches physically and thermally coupled to a heat sink via one or more multi-layer switch substrates.

  15. Implementation of an Integrated, Portable Transformer Condition Monitoring Instrument in the Classroom and On-Site

    ERIC Educational Resources Information Center

    Chatterjee, B.; Dey, D.; Chakravorti, S.

    2010-01-01

    The development of integrated, portable, transformer condition monitoring (TCM) equipment for classroom demonstrations as well as for student exercises conducted in the field is discussed. Demonstrations include experimentation with real-world transformers to illustrate concepts such as polarization and depolarization current through oil-paper…

  16. Integral dose: Comparison between four techniques for prostate radiotherapy

    PubMed Central

    Ślosarek, Krzysztof; Osewski, Wojciech; Grządziel, Aleksandra; Radwan, Michał; Dolla, Łukasz; Szlag, Marta; Stąpór-Fudzińska, Małgorzata

    2014-01-01

    Aim Comparisons of integral dose delivered to the treatment planning volume and to the whole patient body during stereotactic, helical and intensity modulated radiotherapy of prostate. Background Multifield techniques produce large volumes of low dose inside the patient body. Delivered dose could be the result of the cytotoxic injuries of the cells even away from the treatment field. We calculated the total dose absorbed in the patient body for four radiotherapy techniques to investigate whether some methods have a potential to reduce the exposure to the patient. Materials and methods We analyzed CyberKnife plans for 10 patients with localized prostate cancer. Five alternative plans for each patient were calculated with the VMAT, IMRT and TomoTherapy techniques. Alternative dose distributions were calculated to achieve the same coverage for PTV. Integral Dose formula was used to calculate the total dose delivered to the PTV and whole patient body. Results Analysis showed that the same amount of dose was deposited to the treated volume despite different methods of treatment delivery. The mean values of total dose delivered to the whole patient body differed significantly for each treatment technique. The highest integral dose in the patient's body was at the TomoTherapy and CyberKnife treatment session. VMAT was characterized by the lowest integral dose deposited in the patient body. Conclusions The highest total dose absorbed in normal tissue was observed with the use of a robotic radiosurgery system and TomoTherapy. These results demonstrate that the exposure of healthy tissue is a dosimetric factor which differentiates the dose delivery methods. PMID:25859398

  17. Integrating Organic Matter Structure with Ecosystem Function using Advanced Analytical Chemistry Techniques

    NASA Astrophysics Data System (ADS)

    Boot, C. M.

    2012-12-01

    Microorganisms are the primary transformers of organic matter in terrestrial and aquatic ecosystems. The structure of organic matter controls its bioavailability and researchers have long sought to link the chemical characteristics of the organic matter pool to its lability. To date this effort has been primarily attempted using low resolution descriptive characteristics (e.g. organic matter content, carbon to nitrogen ratio, aromaticity, etc .). However, recent progress in linking these two important ecosystem components has been advanced using advanced high resolution tools (e.g. nuclear magnetic resonance (NMR) spectroscopy, and mass spectroscopy (MS)-based techniques). A series of experiments will be presented that highlight the application of high resolution techniques in a variety of terrestrial and aquatic ecosystems with the focus on how these data explicitly provide the foundation for integrating organic matter structure into our concept of ecosystem function. The talk will highlight results from a series of experiments including: an MS-based metabolomics and fluorescence excitation emission matrix approach evaluating seasonal and vegetation based changes in dissolved organic matter (DOM) composition from arctic soils; Fourier transform ion cyclotron resonance (FTICR) MS and MS metabolomics analysis of DOM from three lakes in an alpine watershed; and the transformation of 13C labeled glucose track with NMR during a rewetting experiment from Colorado grassland soils. These data will be synthesized to illustrate how the application of advanced analytical techniques provides novel insight into our understanding of organic matter processing in a wide range of ecosystems.

  18. Computer-Assisted Techniques to Enhance Transformative Learning in First-Year Literature Courses.

    ERIC Educational Resources Information Center

    Jamieson, Marguerite; Kajs, Rebecca; Agee, Anne

    1996-01-01

    Illustrates techniques to foster transformative learning in computer-assisted literature classes: (1) a lesson plan on John Donne's "A Valediction: Forbidding Mourning"; (2) a plan to analyze "Oedipus Rex" using the "Daedalus" Interactive Writing Environment; and (3) a demonstration of how students engage in "meta-reflection" as they explore…

  19. A genomic DNA segment from Petunia hybrida leads to increased transformation frequencies and simple integration patterns.

    PubMed Central

    Meyer, P; Kartzke, S; Niedenhof, I; Heidmann, I; Bussmann, K; Saedler, H

    1988-01-01

    A 2-kilobase (kb) genomic fragment was selected from Petunia hybrida that increased transformation efficiencies by at least a factor of 20 after direct DNA transfer to petunia and tobacco protoplasts when supercoiled plasmid DNA was used. Because of this effect this fragment was named transformation booster sequence (TBS). Increased transformation frequencies were observed for plasmids that contained either the 2-kb fragment in dimeric or monomeric form or an internal 1.1-kb fragment of TBS. Analysis of transformants revealed that preferentially one copy of foreign DNA is integrated. Thus, TBS improves the poor transformation frequencies of direct gene transfer using circular plasmids, while it conserves the simple integration pattern that is important for practical applications. Possible mechanisms of TBS action are discussed. Images PMID:3186747

  20. Integrating the Scholarship on Women: Transforming the Curriculum.

    ERIC Educational Resources Information Center

    Coulter, Sara; Hedges, Elaine

    Townson State University's 3-year project integrated new scholarship on women into the curriculum, with emphasis on introductory survey courses in eight disciplines: art, biology, business, education, English, history, psychology, and sociology. About 70 faculty met in workshops for five semesters to (1) read and discuss new scholarship on women;…

  1. Integrated optics in an electrically scanned imaging Fourier transform spectrometer

    NASA Technical Reports Server (NTRS)

    Breckinridge, James B. (Inventor); Ocallaghan, Fred G. (Inventor)

    1982-01-01

    An efficient, lightweight and stable, Fourier transform spectrometer was developed. The mechanical slide mechanism needed to create a path difference was eliminated by the use of retro-reflecting mirrors in a monolithic interferometer assembly in which the mirrors are not at 90 degrees to the propagation vector of the radiation, but rather at a small angle. The resulting plane wave fronts create a double-sided inteferogram of the source irradiance distribution which is detected by a charge-coupled device image sensor array. The position of each CCD pixel in the array is an indication of the path difference between the two retro-reflecting mirrors in the monolithic optical structure. The Fourier transform of the signals generated by the image sensor provide the spectral irradiance distribution of the source. For imaging, the interferometer assembly scans the source of irradiation by moving the entire instrument, such as would occur if it was fixedly mounted to a moving platform, i.e., a spacecraft. During scanning, the entrace slot to the monolithic optical structure sends different pixels to corresponding interferograms detected by adjacent columns of pixels of the image sensor.

  2. Transforming Water Management: an Emerging Promise of Integrated Earth Observations

    NASA Astrophysics Data System (ADS)

    Lawford, R. G.

    2011-12-01

    Throughout its history, civilization has relied on technology to facilitate many of its advances. New innovations and technologies have often provided strategic advantages that have led to transformations in institutions, economies and ultimately societies. Observational and information technologies are leading to significant developments in the water sector. After a brief introduction tracing the role of observational technologies in the areas of hydrology and water cycle science, this talk explores the existing and potential contributions of remote sensing data in water resource management around the world. In particular, it outlines the steps being undertaken by the Group on Earth Observations (GEO) and its Water Task to facilitate capacity building efforts in water management using Earth Observations in Asia, Africa and Latin and Caribbean America. Success stories on the benefits of using Earth Observations and applying GEO principles are provided. While GEO and its capacity building efforts are contributing to the transformation of water management through interoperability, data sharing, and capacity building, the full potential of these contributions has not been fully realized because impediments and challenges still remain.

  3. Interferometry based multispectral photon-limited 2D and 3D integral image encryption employing the Hartley transform.

    PubMed

    Muniraj, Inbarasan; Guo, Changliang; Lee, Byung-Geun; Sheridan, John T

    2015-06-15

    We present a method of securing multispectral 3D photon-counted integral imaging (PCII) using classical Hartley Transform (HT) based encryption by employing optical interferometry. This method has the simultaneous advantages of minimizing complexity by eliminating the need for holography recording and addresses the phase sensitivity problem encountered when using digital cameras. These together with single-channel multispectral 3D data compactness, the inherent properties of the classical photon counting detection model, i.e. sparse sensing and the capability for nonlinear transformation, permits better authentication of the retrieved 3D scene at various depth cues. Furthermore, the proposed technique works for both spatially and temporally incoherent illumination. To validate the proposed technique simulations were carried out for both the 2D and 3D cases. Experimental data is processed and the results support the feasibility of the encryption method. PMID:26193568

  4. 76 FR 63941 - Agency Information Collection Activities: Business Transformation-Automated Integrated Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ..., 2011, USCIS published a 60-day notice in the Federal Register at 76 FR 1745, seeking comment on USCIS's information collection request for the Automated Integrated Operating Environment (IOE). The comment period... Transformation--Automated Integrated Operating Environment (IOE), New Information Collection; Comment...

  5. First integrals for time-dependent higher-order Riccati equations by nonholonomic transformation

    NASA Astrophysics Data System (ADS)

    Guha, Partha; Ghose Choudhury, A.; Khanra, Barun

    2011-08-01

    We exploit the notion of nonholonomic transformations to deduce a time-dependent first integral for a (generalized) second-order nonautonomous Riccati differential equation. It is further shown that the method can also be used to compute the first integrals of a particular class of third-order time-dependent ordinary differential equations and is therefore quite robust.

  6. Multispectral image sharpening using wavelet transform techniques and spatial correlation of edges

    USGS Publications Warehouse

    Lemeshewsky, George P.; Schowengerdt, Robert A.

    2000-01-01

    Several reported image fusion or sharpening techniques are based on the discrete wavelet transform (DWT). The technique described here uses a pixel-based maximum selection rule to combine respective transform coefficients of lower spatial resolution near-infrared (NIR) and higher spatial resolution panchromatic (pan) imagery to produce a sharpened NIR image. Sharpening assumes a radiometric correlation between the spectral band images. However, there can be poor correlation, including edge contrast reversals (e.g., at soil-vegetation boundaries), between the fused images and, consequently, degraded performance. To improve sharpening, a local area-based correlation technique originally reported for edge comparison with image pyramid fusion is modified for application with the DWT process. Further improvements are obtained by using redundant, shift-invariant implementation of the DWT. Example images demonstrate the improvements in NIR image sharpening with higher resolution pan imagery.

  7. Analytically reduced form of multicenter integrals from Gaussian transforms. [in atomic and molecular physics

    NASA Technical Reports Server (NTRS)

    Straton, Jack C.

    1989-01-01

    The four-dimensional Fourier-Feynman transformations previously used in analytically reducing the general class of integrals containing multicenter products of 1s hydrogenic orbitals, Coulomb or Yukawa potentials, and plane waves, are replaced by the one-dimensional Gaussian transformation. This reduces the previously required double-diagonalization of the quadratic form of the multicenter integrals to only one diagonalization, yielding a simpler reduced form of the integral. The present work also extends the result to include all s states and pairs of states with l not equal to zero summed over the m quantum number.

  8. Design of time-pulse coded optoelectronic neuronal elements for nonlinear transformation and integration

    NASA Astrophysics Data System (ADS)

    Krasilenko, Vladimir G.; Nikolsky, Alexander I.; Lazarev, Alexander A.; Lazareva, Maria V.

    2008-03-01

    In the paper the actuality of neurophysiologically motivated neuron arrays with flexibly programmable functions and operations with possibility to select required accuracy and type of nonlinear transformation and learning are shown. We consider neurons design and simulation results of multichannel spatio-time algebraic accumulation - integration of optical signals. Advantages for nonlinear transformation and summation - integration are shown. The offered circuits are simple and can have intellectual properties such as learning and adaptation. The integrator-neuron is based on CMOS current mirrors and comparators. The performance: consumable power - 100...500 μW, signal period- 0.1...1ms, input optical signals power - 0.2...20 μW time delays - less 1μs, the number of optical signals - 2...10, integration time - 10...100 of signal periods, accuracy or integration error - about 1%. Various modifications of the neuron-integrators with improved performance and for different applications are considered in the paper.

  9. Harnessing modified manganin technique to study processes of explosive transformation in pyrotechnic compositions

    NASA Astrophysics Data System (ADS)

    Batalov, Sergei

    2005-07-01

    The paper reviews results of the experimental study of explosive transformation in pyrotechnic compositions with modified manganin technique. In particular, experimental data on pressure profiles recorded with tiny manganin sensors are cited to characterize the effect of parameters of the loading pulse, dispersion and density on peculiarities of explosive transformation in studied pyrotechnic pieces under shock-wave initiation. In the paper are shown the experimental pressure profiles, characteristic for processes of explosive transformation of extended delay. The experimental results prove the effect of density variation of the specimens under study on the process of the explosive transformation. It is felt that for given range of pressures of the incoming shock wave the difference of the explosive transformation history, at equal parameters of loading pulse, is caused also by different dispersion of the initial powder and final porosity of studied specimens. The experimental results provide support for possibility of use of tiny manganin and constantan sensors in studying processes of explosive transformation of pyrotechnic compositions under initiation by divergent shock waves of large curve front and slumping pressure profile.

  10. Integrated zone comparison polygraph technique accuracy with scoring algorithms.

    PubMed

    Gordon, Nathan J; Mohamed, Feroze B; Faro, Scott H; Platek, Steven M; Ahmad, Harris; Williams, J Michael

    2006-02-28

    The Integrated Zone Comparison Technique (IZCT) was utilized with computerized polygraph instrumentation as part of a blind study in the detection of deception. Three scoring algorithms: ASIT Poly Suite (Academy for Scientific Investigative Training's Horizontal Scoring and Algorithm for Chart Interpretation), PolyScore 5.5, and the Objective Scoring System (OSS) were assessed in the interpretation of the charts generated. Where "Inconclusives" were excluded, accuracy for the IZCT with all three algorithms was 100%. When "Inconclusives" were counted as errors, overall accuracy for the IZCT with ASIT Poly Suite was 90% and accuracy with PolyScore and the Objective Scoring System was 72%.

  11. Stability of numerical integration techniques for transient rotor dynamics

    NASA Technical Reports Server (NTRS)

    Kascak, A. F.

    1977-01-01

    A finite element model of a rotor bearing system was analyzed to determine the stability limits of the forward, backward, and centered Euler; Runge-Kutta; Milne; and Adams numerical integration techniques. The analysis concludes that the highest frequency mode determines the maximum time step for a stable solution. Thus, the number of mass elements should be minimized. Increasing the damping can sometimes cause numerical instability. For a uniform shaft, with 10 mass elements, operating at approximately the first critical speed, the maximum time step for the Runge-Kutta, Milne, and Adams methods is that which corresponds to approximately 1 degree of shaft movement. This is independent of rotor dimensions.

  12. Integration of Field and Remote Sensing Techniques For Landslides Monitoring

    NASA Astrophysics Data System (ADS)

    Allievi, J.; Ambrosi, C.; Ceriani, M.; Colesanti, C.; Crosta, G. B.; Ferretti, A.; Fossati, D.; Menegaz, A.

    The definition of the state of activity of slope movements is of major interest both at local and at regional scale. The Geological Survey of the Regione Lombardia has re- cently started a series of projects aimed to the identification of areas subjected to slope instability and to the assessment of their state of activity. Field survey, aerial photo interpretation and advanced remote sensing techniques have been applied. Some ex- amples of large rock slope instabilities have been investigated in the Valtellina area (Lombardia, Northern Italy). In particular, we demonstrate the degree of integration of the adopted techniques for one of the largest rock slope movements actually recog- nised in the area. The remote sensing approach that has been adopted is the Perma- nent Scatterers (PS) Technique. This technique has been recently developed as a new methodology for surface deformation monitoring, using ESA ERS-SAR data. Its ap- plication to large slope movements in alpine and prealpine areas, with a relatively low urban development, has been tried for the first time in order to evaluate its potential in supporting studies for landslide hazard assessment. Previous results show that this ap- proach allows to reach an accuracy very close to the theoretical limit. This study shows the very good agreement reached for displacement velocities between historical trends and recent PS measurements. Scatterers have been identified by field surveying and some of them are located close to historically monitored benchmark for topographic measurements. Furthermore, the integration of these data with field observations al- lowed us to perform a preliminary reconstrucion of the landslide mechanism and to assess the activity of different landslide structures (scarps, etc.).

  13. A technique for constructing an integrated scene from multiple viewing angles using a tactical ranging sensor

    NASA Astrophysics Data System (ADS)

    VanMaasdam, Peter J.; Riddle, Jack G.

    2003-09-01

    The problem of seamless scene integration from multiple 3-dimensional views of a location for surveillance or recognition purposes is one that continues to receive much interest. This technique holds the promise of increased ability to detect concealed targets, as well as better visualization of the scene itself. The process of creating an integrated scene 'model' from multiple range images taken at different views of the scene consists of several basic steps: (1) Matching of scene points across views, (2) Registration of the multiple views to a common reference frame, and (3) Integration of the multiple views into a complete 3D representation (such as a mesh or voxel space). We propose using a technique known as spin-map correlation to compute the initial scene point correspondences between views. This technique has the advantage of being able to perform the registration with minimal knowledge of viewing geometry or viewer location - the only requirement is that there is overlap between views. Registration is performed using the correspondences generated from spin-map matching to seed an Iterative Closest Point (ICP) algorithm. The ICP algorithm grows the list of correspondences and estimates the rigid transformation between the multiple views. Following registration of the disparate views, the surface is represented probabilistically in a voxel space that is then polygonised into a triangular facet model using the well-known marching cubes algorithm. We demonstrate this procedure using LADAR range images of an armored vehicle of interest.

  14. Integrative Approach for a Transformative Freshman-Level STEM Curriculum

    PubMed Central

    Curran, Kathleen L.; Olsen, Paul E.; Nwogbaga, Agashi P.; Stotts, Stephanie

    2016-01-01

    In 2014 Wesley College adopted a unified undergraduate program of evidence-based high-impact teaching practices. Through foundation and federal and state grant support, the college completely revised its academic core curriculum and strengthened its academic support structures by including a comprehensive early alert system for at-risk students. In this core, science, technology, engineering, and mathematics (STEM) faculty developed fresh manifestations of integrated concept-based introductory courses and revised upper-division STEM courses around student-centered learning. STEM majors can participate in specifically designed paid undergraduate research experiences in directed research elective courses. Such a college-wide multi-tiered approach results in institutional cultural change. PMID:27064213

  15. Integrated Surveying Techniques for Sensitive Areas: San Felice Sul Panaro

    NASA Astrophysics Data System (ADS)

    Ballarin, M.; Buttolo, V.; Guerra, F.; Vernier, P.

    2013-07-01

    The last few years have marked an exponential growth in the use of electronic and computing technologies that opened new possibilities and new scenarios in the Geomatic field. This evolution of tools and methods has led to new ways of approaching survey. For what concerns architecture, the new tools for survey acquisition and 3D modelling allow the representation of an object through a digital model, combining the visual potentials of images, normally used for documentation, with the precision of a metric survey. This research focuses on the application of these new technologies and methodologies on sensitive areas, such as portions of the cities affected by earthquakes. In this field the survey is intended to provide a useful support for other structural analysis, in conservation as well as for restoration studies. However, survey in architecture is still a very complex operation both from a methodological and a practical point of view: it requires a critical interpretation of the artefacts and a deep knowledge of the existing techniques and technologies, which often are very different but need to be integrated within a single general framework. This paper describes the first results of the survey conducted on the church of San Geminiano in San Felice sul Panaro (Modena). Here, different tools and methods were used, in order to create a new system that integrates the most recent and cutting-edge technologies in the Geomatic field. The methodologies used were laser scanning, UAV photogrammetry and topography for the definition of the reference system. The present work will focus on the data acquisition and processing whit these techniques and their integration.

  16. Cost-Optimal Design of a 3-Phase Core Type Transformer by Gradient Search Technique

    NASA Astrophysics Data System (ADS)

    Basak, R.; Das, A.; Sensarma, A. K.; Sanyal, A. N.

    2014-04-01

    3-phase core type transformers are extensively used as power and distribution transformers in power system and their cost is a sizable proportion of the total system cost. Therefore they should be designed cost-optimally. The design methodology for reaching cost-optimality has been discussed in details by authors like Ramamoorty. It has also been discussed in brief in some of the text-books of electrical design. The paper gives a method for optimizing design, in presence of constraints specified by the customer and the regulatory authorities, through gradient search technique. The starting point has been chosen within the allowable parameter space the steepest decent path has been followed for convergence. The step length has been judiciously chosen and the program has been maneuvered to avoid local minimal points. The method appears to be best as its convergence is quickest amongst different optimizing techniques.

  17. Transformation of full 4 × 4 Mueller matrices: a quantitative technique for biomedical diagnosis

    NASA Astrophysics Data System (ADS)

    He, Honghui; Chang, Jintao; He, Chao; Ma, Hui

    2016-03-01

    Polarization images contain abundant microstructural information of samples. Recently, as a comprehensive description of the structural and optical properties of complex media, the Mueller matrix imaging has been widely applied to biomedical studies, especially cancer detections. In previous works, we proposed a technique to transform the backscattering 3 × 3 Mueller matrices into a group of quantitative parameters with clear relationships to specific microstructures. In this paper, we extend this transformation method to full 4 × 4 Mueller matrices of both the back and forward scattering directions. Using the experimental results of phantoms and Monte Carlo simulation based on the sphere-cylinder birefringence model, we fit the Mueller matrix elements to trigonometric curves in polar coordinates and obtain a new set of transformation parameters, which can be expressed as analytical functions of 16 Mueller matrix elements. Both the experimental and simulated results demonstrate that the transformation parameters have simple relationships to the characteristic microstructural properties, including the densities and orientations of fibrous structures, the sizes of the scatterers, and the depolarization power of the samples. We also apply the transformation parameters of full 4 × 4 Mueller matrices to human liver cancerous tissues. Preliminary imaging results show that the parameters can quantitatively reflect the formation of fibrous birefringent tissues accompanying the cancerous processes. The findings presented in this study can be useful for in vivo or in vitro polarization imaging of tissues for diagnostic applications.

  18. Fast x-ray microdiffraction techniques for studying irreversible transformations in materials.

    SciTech Connect

    Kelly, S. T.; Trenkle, J. C.; Koerner, L. J.; Barron, S. C.; Walker, N.; Pouliquen, P. O.; Tate, M. W.; Gruner, S. M.; Dufresne, E. M.; Weihs, T. P.; Hufnagel, T. C.

    2011-05-01

    A pair of techniques have been developed for performing time-resolved X-ray microdiffraction on irreversible phase transformations. In one technique capillary optics are used to focus a high-flux broad-spectrum X-ray beam to a 60 {micro}m spot size and a fast pixel array detector is used to achieve temporal resolution of 55 {micro}s. In the second technique the X-rays are focused with Kirkpatrick-Baez mirrors to achieve a spatial resolution better than 10 {micro}m and a fast shutter is used to provide temporal resolution better than 20 {micro}s while recording the diffraction pattern on a (relatively slow) X-ray CCD camera. Example data from experiments are presented where these techniques are used to study self-propagating high-temperature synthesis reactions in metal laminate foils.

  19. Fast X-ray microdiffraction techniques for studying irreversible transformations in materials

    PubMed Central

    Kelly, Stephen T.; Trenkle, Jonathan C.; Koerner, Lucas J.; Barron, Sara C.; Walker, Nöel; Pouliquen, Philippe O.; Tate, Mark W.; Gruner, Sol M.; Dufresne, Eric M.; Weihs, Timothy P.; Hufnagel, Todd C.

    2011-01-01

    A pair of techniques have been developed for performing time-resolved X-ray microdiffraction on irreversible phase transformations. In one technique capillary optics are used to focus a high-flux broad-spectrum X-ray beam to a 60 µm spot size and a fast pixel array detector is used to achieve temporal resolution of 55 µs. In the second technique the X-rays are focused with Kirkpatrick–Baez mirrors to achieve a spatial resolution better than 10 µm and a fast shutter is used to provide temporal resolution better than 20 µs while recording the diffraction pattern on a (relatively slow) X-ray CCD camera. Example data from experiments are presented where these techniques are used to study self-propagating high-temperature synthesis reactions in metal laminate foils. PMID:21525656

  20. Darboux Transformation for the Vector Sine-Gordon Equation and Integrable Equations on a Sphere

    NASA Astrophysics Data System (ADS)

    Mikhailov, Alexander V.; Papamikos, Georgios; Wang, Jing Ping

    2016-07-01

    We propose a method for construction of Darboux transformations, which is a new development of the dressing method for Lax operators invariant under a reduction group. We apply the method to the vector sine-Gordon equation and derive its Bäcklund transformations. We show that there is a new Lax operator canonically associated with our Darboux transformation resulting an evolutionary differential-difference system on a sphere. The latter is a generalised symmetry for the chain of Bäcklund transformations. Using the re-factorisation approach and the Bianchi permutability of the Darboux transformations, we derive new vector Yang-Baxter map and integrable discrete vector sine-Gordon equation on a sphere.

  1. Techniques to Access Databases and Integrate Data for Hydrologic Modeling

    SciTech Connect

    Whelan, Gene; Tenney, Nathan D.; Pelton, Mitchell A.; Coleman, Andre M.; Ward, Duane L.; Droppo, James G.; Meyer, Philip D.; Dorow, Kevin E.; Taira, Randal Y.

    2009-06-17

    This document addresses techniques to access and integrate data for defining site-specific conditions and behaviors associated with ground-water and surface-water radionuclide transport applicable to U.S. Nuclear Regulatory Commission reviews. Environmental models typically require input data from multiple internal and external sources that may include, but are not limited to, stream and rainfall gage data, meteorological data, hydrogeological data, habitat data, and biological data. These data may be retrieved from a variety of organizations (e.g., federal, state, and regional) and source types (e.g., HTTP, FTP, and databases). Available data sources relevant to hydrologic analyses for reactor licensing are identified and reviewed. The data sources described can be useful to define model inputs and parameters, including site features (e.g., watershed boundaries, stream locations, reservoirs, site topography), site properties (e.g., surface conditions, subsurface hydraulic properties, water quality), and site boundary conditions, input forcings, and extreme events (e.g., stream discharge, lake levels, precipitation, recharge, flood and drought characteristics). Available software tools for accessing established databases, retrieving the data, and integrating it with models were identified and reviewed. The emphasis in this review was on existing software products with minimal required modifications to enable their use with the FRAMES modeling framework. The ability of four of these tools to access and retrieve the identified data sources was reviewed. These four software tools were the Hydrologic Data Acquisition and Processing System (HDAPS), Integrated Water Resources Modeling System (IWRMS) External Data Harvester, Data for Environmental Modeling Environmental Data Download Tool (D4EM EDDT), and the FRAMES Internet Database Tools. The IWRMS External Data Harvester and the D4EM EDDT were identified as the most promising tools based on their ability to access and

  2. Slit Function Measurement of An Imaging Spectrograph Using Fourier Transform Techniques

    NASA Technical Reports Server (NTRS)

    Park, Hongwoo; Swimyard, Bruce; Jakobsen, Peter; Moseley, Harvey; Greenhouse, Matthew

    2004-01-01

    Knowledge of a spectrograph slit function is necessary to interpret the unresolved lines in an observed spectrum. A theoretical slit function can be calculated from the sizes of the entrance slit, the detector aperture when it functions as an exit slit, the dispersion characteristic of the disperser, and the point spread function of the spectrograph. A measured slit function is preferred to the theoretical one for the correct interpretation of the spectral data. In a scanning spectrometer with a single exit slit, the slit function is easily measured. In a fixed grating/or disperser spectrograph, illuminating the entrance slit with a near monochromatic light from a pre-monochrmator or a tunable laser and varying the wavelength of the incident light can measure the slit function. Even though the latter technique had been used successfully for the slit function measurements, it had been very laborious and it would be prohibitive to an imaging spectrograph or a multi-object spectrograph that has a large field of view. We explore an alternative technique that is manageable for the measurements. In the proposed technique, the imaging spectrograph is used as a detector of a Fourier transform spectrometer. This method can be applied not only to an IR spectrograph but also has a potential to a visible/UV spectrograph including a wedge filter spectrograph. This technique will require a blackbody source of known temperature and a bolometer to characterize the interferometer part of the Fourier Transform spectrometer. This pa?er will describe the alternative slit function measurement technique using a Fourier transform spectrometer.

  3. An integrated sensing technique for smart monitoring of water pipelines

    NASA Astrophysics Data System (ADS)

    Bernini, Romeo; Catapano, Ilaria; Soldovieri, Francesco; Crocco, Lorenzo

    2014-05-01

    Lowering the rate of water leakage from the network of underground pipes is one of the requirements that "smart" cities have to comply with. In fact, losses in the water supply infrastructure have a remarkable social, environmental and economic impact, which obviously conflicts with the expected efficiency and sustainability of a smart city. As a consequence, there is a huge interest in developing prevention policies based on state-of-art sensing techniques and possibly their integration, as well as in envisaging ad hoc technical solutions designed for the application at hand. As a contribution to this framework, in this communication we present an approach aimed to pursue a thorough non-invasive monitoring of water pipelines, with both high spatial and temporal resolution. This goal is necessary to guarantee that maintenance operations are performed timely, so to reduce the extent of the leakage and its possible side effects, and precisely, so to minimize the cost and the discomfort resulting from operating on the water supply network. The proposed approach integrates two sensing techniques that work at different spatial and temporal scales. The first one is meant to provide a continuous (in both space and time) monitoring of the pipeline and exploits a distributed optic fiber sensor based on the Brillouin scattering phenomenon. This technique provides the "low" spatial resolution information (at meter scale) needed to reveal the presence of a leak and call for interventions [1]. The second technique is based on the use of Ground Penetrating Radar (GPR) and is meant to provide detailed images of area where the damage has been detected. GPR systems equipped with suitable data processing strategies [2,3] are indeed capable of providing images of the shallow underground, where the pipes would be buried, characterized by a spatial resolution in the order of a few centimeters. This capability is crucial to address in the most proper way maintenance operations, by for

  4. Integrative techniques related to positive processes in psychotherapy.

    PubMed

    Cromer, Thomas D

    2013-09-01

    This review compiles and evaluates a number of therapist interventions that have been found to significantly contribute to positive psychotherapy processes (i.e., increased alliance, patient engagement/satisfaction, and symptomatic improvement). Four forms of intervention are presented: Affect-focused, Supportive, Exploratory, and Patient-Therapist Interaction. The intention of this review is to link specific interventions to applied practice so that integrative clinicians can potentially use these techniques to improve their clinical work. To this end, there is the inclusion of theory and empirical studies from a range of orientations including Emotionally Focused, Psychodynamic, Client-Centered, Cognitive-Behavioral, Interpersonal, Eclectic, and Motivational Interviewing. Each of the four sections will include the theoretical basis and proposed mechanism of change for the intervention, research that supports its positive impact on psychotherapy processes, and conclude with examples demonstrating its use in actual practice. Clinical implications and considerations regarding the use of these interventions will also be presented.

  5. Integration or transformation? Looking in the future of Information and Communication Technology in education in Vietnam.

    PubMed

    Peeraer, Jef; Van Petegem, Peter

    2015-02-01

    Over the last two decades, crucial factors for Information and Communication Technology (ICT) in education have improved significantly in Vietnam. Nevertheless, it is clear that, as in other countries, no educational revolution is taking place. We argue that there is a need for a broad dialogue on the future of ICT in education in Vietnam as discussion of ideas about future possibilities can be instrumental in rationalizing and generating educational change. We explore how a group of key players representing the public and private sector as well as development partners in the field look at the future of ICT in education in the country. Following the Delphi method, these key players assessed in different survey rounds the current situation of ICT in education, identified a series of targets and were asked to assess these targets in respect of their importance. The key players reached a consensus that the purpose of technology integration is to achieve learning goals and enhance learning. However, there is more controversy on targets that could potentially transform education practice in Vietnam. We discuss the value of the Delphi technique and argue for increased participation of all involved stakeholders in policy development on ICT in education.

  6. Integration or transformation? Looking in the future of Information and Communication Technology in education in Vietnam.

    PubMed

    Peeraer, Jef; Van Petegem, Peter

    2015-02-01

    Over the last two decades, crucial factors for Information and Communication Technology (ICT) in education have improved significantly in Vietnam. Nevertheless, it is clear that, as in other countries, no educational revolution is taking place. We argue that there is a need for a broad dialogue on the future of ICT in education in Vietnam as discussion of ideas about future possibilities can be instrumental in rationalizing and generating educational change. We explore how a group of key players representing the public and private sector as well as development partners in the field look at the future of ICT in education in the country. Following the Delphi method, these key players assessed in different survey rounds the current situation of ICT in education, identified a series of targets and were asked to assess these targets in respect of their importance. The key players reached a consensus that the purpose of technology integration is to achieve learning goals and enhance learning. However, there is more controversy on targets that could potentially transform education practice in Vietnam. We discuss the value of the Delphi technique and argue for increased participation of all involved stakeholders in policy development on ICT in education. PMID:25305806

  7. Modern integral equation techniques for quantum reactive scattering theory

    SciTech Connect

    Auerbach, S.M.

    1993-11-01

    Rigorous calculations of cross sections and rate constants for elementary gas phase chemical reactions are performed for comparison with experiment, to ensure that our picture of the chemical reaction is complete. We focus on the H/D+H{sub 2} {yields} H{sub 2}/DH + H reaction, and use the time independent integral equation technique in quantum reactive scattering theory. We examine the sensitivity of H+H{sub 2} state resolved integral cross sections {sigma}{sub v{prime}j{prime},vj}(E) for the transitions (v = 0,j = 0) to (v{prime} = 1,j{prime} = 1,3), to the difference between the Liu-Siegbahn-Truhlar-Horowitz (LSTH) and double many body expansion (DMBE) ab initio potential energy surfaces (PES). This sensitivity analysis is performed to determine the origin of a large discrepancy between experimental cross sections with sharply peaked energy dependence and theoretical ones with smooth energy dependence. We find that the LSTH and DMBE PESs give virtually identical cross sections, which lends credence to the theoretical energy dependence.

  8. Integration of geological remote-sensing techniques in subsurface analysis

    USGS Publications Warehouse

    Taranik, James V.; Trautwein, Charles M.

    1976-01-01

    Geological remote sensing is defined as the study of the Earth utilizing electromagnetic radiation which is either reflected or emitted from its surface in wavelengths ranging from 0.3 micrometre to 3 metres. The natural surface of the Earth is composed of a diversified combination of surface cover types, and geologists must understand the characteristics of surface cover types to successfully evaluate remotely-sensed data. In some areas landscape surface cover changes throughout the year, and analysis of imagery acquired at different times of year can yield additional geological information. Integration of different scales of analysis allows landscape features to be effectively interpreted. Interpretation of the static elements displayed on imagery is referred to as an image interpretation. Image interpretation is dependent upon: (1) the geologist's understanding of the fundamental aspects of image formation, and (2.) his ability to detect, delineate, and classify image radiometric data; recognize radiometric patterns; and identify landscape surface characteristics as expressed on imagery. A geologic interpretation integrates surface characteristics of the landscape with subsurface geologic relationships. Development of a geologic interpretation from imagery is dependent upon: (1) the geologist's ability to interpret geomorphic processes from their static surface expression as landscape characteristics on imagery, (2) his ability to conceptualize the dynamic processes responsible for the evolution 6f interpreted geologic relationships (his ability to develop geologic models). The integration of geologic remote-sensing techniques in subsurface analysis is illustrated by development of an exploration model for ground water in the Tucson area of Arizona, and by the development of an exploration model for mineralization in southwest Idaho.

  9. A model for integration of DNA into the genome during transformation of Fusarium graminearum.

    PubMed

    Watson, R J; Burchat, S; Bosley, J

    2008-10-01

    Transformants of Fusarium graminearum were derived using linearized DNA of plasmids designed to replace the trichodiene synthase gene, a cutinase gene or a xylanase gene with a hygromycin-resistance marker cassette by homologous recombination between 1-kbp segments of flanking DNA. Most transformants did not exhibit the DNA structure expected of integration by classical double recombination. Instead, they contained linearized plasmid joined end-to-end and variably incorporated into the genome. Transformant types included ectopic integrations and integrations at the target site with or without removal of the targeted gene. We have analyzed a large number of transformants using cloning, PCR and DNA sequencing to determine the structures of their integrated DNA, and describe a model to explain their derivations. The data indicate that 1-3 copies of input DNA are first joined end-to-end to produce either linear or circular structures, probably mediated by the non-homologous end-joining (NHEJ) system. The end-joins typically have 1-5 nucleotides in common and are near or within the original cleavage site of the plasmid. Ectopic integrations occur by attaching linear DNA to two ends of genomic DNA via the same joining mechanism. Integration at the target site is consistent with replication around circularized input DNA, beginning and ending within the flanking homologous DNA, resulting in the integration of multiple copies of the entire structure. This results in deletion or duplication of the target site, or leaves one copy at either end of the integrated multimer. Reiterated DNA in the more complex structures is unstable due to homologous recombination, such that conversion to simpler forms is detected. PMID:18722542

  10. Helicity is the only integral invariant of volume-preserving transformations

    PubMed Central

    Enciso, Alberto; Peralta-Salas, Daniel; de Lizaur, Francisco Torres

    2016-01-01

    We prove that any regular integral invariant of volume-preserving transformations is equivalent to the helicity. Specifically, given a functional ℐ defined on exact divergence-free vector fields of class C1 on a compact 3-manifold that is associated with a well-behaved integral kernel, we prove that ℐ is invariant under arbitrary volume-preserving diffeomorphisms if and only if it is a function of the helicity. PMID:26864201

  11. Sparse regularization techniques provide novel insights into outcome integration processes.

    PubMed

    Mohr, Holger; Wolfensteller, Uta; Frimmel, Steffi; Ruge, Hannes

    2015-01-01

    By exploiting information that is contained in the spatial arrangement of neural activations, multivariate pattern analysis (MVPA) can detect distributed brain activations which are not accessible by standard univariate analysis. Recent methodological advances in MVPA regularization techniques have made it feasible to produce sparse discriminative whole-brain maps with highly specific patterns. Furthermore, the most recent refinement, the Graph Net, explicitly takes the 3D-structure of fMRI data into account. Here, these advanced classification methods were applied to a large fMRI sample (N=70) in order to gain novel insights into the functional localization of outcome integration processes. While the beneficial effect of differential outcomes is well-studied in trial-and-error learning, outcome integration in the context of instruction-based learning has remained largely unexplored. In order to examine neural processes associated with outcome integration in the context of instruction-based learning, two groups of subjects underwent functional imaging while being presented with either differential or ambiguous outcomes following the execution of varying stimulus-response instructions. While no significant univariate group differences were found in the resulting fMRI dataset, L1-regularized (sparse) classifiers performed significantly above chance and also clearly outperformed the standard L2-regularized (dense) Support Vector Machine on this whole-brain between-subject classification task. Moreover, additional L2-regularization via the Elastic Net and spatial regularization by the Graph Net improved interpretability of discriminative weight maps but were accompanied by reduced classification accuracies. Most importantly, classification based on sparse regularization facilitated the identification of highly specific regions differentially engaged under ambiguous and differential outcome conditions, comprising several prefrontal regions previously associated with

  12. Chemical Transformation System: Cloud Based Cheminformatic Services to Support Integrated Environmental Modeling

    EPA Science Inventory

    Integrated Environmental Modeling (IEM) systems that account for the fate/transport of organics frequently require physicochemical properties as well as transformation products. A myriad of chemical property databases exist but these can be difficult to access and often do not co...

  13. TRANSFORMATION

    SciTech Connect

    LACKS,S.A.

    2003-10-09

    Transformation, which alters the genetic makeup of an individual, is a concept that intrigues the human imagination. In Streptococcus pneumoniae such transformation was first demonstrated. Perhaps our fascination with genetics derived from our ancestors observing their own progeny, with its retention and assortment of parental traits, but such interest must have been accelerated after the dawn of agriculture. It was in pea plants that Gregor Mendel in the late 1800s examined inherited traits and found them to be determined by physical elements, or genes, passed from parents to progeny. In our day, the material basis of these genetic determinants was revealed to be DNA by the lowly bacteria, in particular, the pneumococcus. For this species, transformation by free DNA is a sexual process that enables cells to sport new combinations of genes and traits. Genetic transformation of the type found in S. pneumoniae occurs naturally in many species of bacteria (70), but, initially only a few other transformable species were found, namely, Haemophilus influenzae, Neisseria meningitides, Neisseria gonorrheae, and Bacillus subtilis (96). Natural transformation, which requires a set of genes evolved for the purpose, contrasts with artificial transformation, which is accomplished by shocking cells either electrically, as in electroporation, or by ionic and temperature shifts. Although such artificial treatments can introduce very small amounts of DNA into virtually any type of cell, the amounts introduced by natural transformation are a million-fold greater, and S. pneumoniae can take up as much as 10% of its cellular DNA content (40).

  14. Pattern Transformation of Heat-Shrinkable Polymer by Three-Dimensional (3D) Printing Technique

    PubMed Central

    Zhang, Quan; Yan, Dong; Zhang, Kai; Hu, Gengkai

    2015-01-01

    A significant challenge in conventional heat-shrinkable polymers is to produce controllable microstructures. Here we report that the polymer material fabricated by three-dimensional (3D) printing technique has a heat-shrinkable property, whose initial microstructure can undergo a spontaneous pattern transformation under heating. The underlying mechanism is revealed by evaluating internal strain of the printed polymer from its fabricating process. It is shown that a uniform internal strain is stored in the polymer during the printing process and can be released when heated above its glass transition temperature. Furthermore, the internal strain can be used to trigger the pattern transformation of the heat-shrinkable polymer in a controllable way. Our work provides insightful ideas to understand a novel mechanism on the heat-shrinkable effect of printed material, but also to present a simple approach to fabricate heat-shrinkable polymer with a controllable thermo-structural response. PMID:25757881

  15. Adaptive narrow-band interference rejection in a DS spread-spectrum intercept receiver using transform domain signal processing techniques

    NASA Technical Reports Server (NTRS)

    Gevargiz, John; Das, Pankaj K.; Milstein, Laurence B.

    1989-01-01

    An intercept receiver which uses a transform-domain-processing filter is described. This receiver detects direct-sequence BPSK spread-spectrum signals in the presence of narrowband interference by employing adaptive narrowband interference rejection techniques. The improvement in the system performance over that of conventional detection techniques is shown by presenting the results of experimental measurements of probability of detection versus false alarm for an enhanced total power detector. Also presented are certain results corresponding to detection of the spectral lines generated at twice the carrier frequency, wherein the goal is often not just signal detection, but also carrier frequency estimation. The receiver uses one of two transform-domain-processing techniques for adaptive narrowband interference rejection. In the first technique, the narrowband interference is detected and excised in the transform domain by using an adaptive notch filter. In the second technique, the interference is suppressed using soft-limiting in the transform domain.

  16. Classification of the quantum two-dimensional superintegrable systems with quadratic integrals and the Staeckel transforms

    SciTech Connect

    Daskaloyannis, C. Tanoudis, Y.

    2008-05-15

    The two-dimensional quantum superintegrable systems with quadratic integrals of motion on a manifold are classified by using the quadratic associative algebra of the integrals of motion. There are six general fundamental classes of quantum superintegrable systems corresponding to the classical ones. Analytic formulas for the involved integrals are calculated in all the cases. All the known quantum superintegrable systems with quadratic integrals are classified as special cases of these six general classes. The coefficients of the quadratic associative algebra of integrals are calculated and they are compared to the coefficients of the corresponding coefficients of the Poisson quadratic algebra of the classical systems. The quantum coefficients are similar to the classical ones multiplied by a quantum coefficient -{h_bar}{sup 2} plus a quantum deformation of order {h_bar}{sup 4} and {h_bar}{sup 6}. The systems inside the classes are transformed using Staeckel transforms in the quantum case as in the classical case. The general form of the Staeckel transform between superintegrable systems is discussed.

  17. TRANSFORMER

    DOEpatents

    Baker, W.R.

    1959-08-25

    Transformers of a type adapted for use with extreme high power vacuum tubes where current requirements may be of the order of 2,000 to 200,000 amperes are described. The transformer casing has the form of a re-entrant section being extended through an opening in one end of the cylinder to form a coaxial terminal arrangement. A toroidal multi-turn primary winding is disposed within the casing in coaxial relationship therein. In a second embodiment, means are provided for forming the casing as a multi-turn secondary. The transformer is characterized by minimized resistance heating, minimized external magnetic flux, and an economical construction.

  18. Integration of Geomatic Techniques for the Urban Cavity Survey

    NASA Astrophysics Data System (ADS)

    Deidda, M.; Sanna, G.

    2013-07-01

    Cagliari, county seat of Sardinia Region (Italy), situated in the southern part of the island, is characterized by a subsoil full of cavities. The excavations in fact, which lasted more than 4000 years, had a great development due also to the special geological characteristics of the city subsoil. The underground voids, which the city is rich in, belong to different classes such as hydraulic structures (aqueducts, cisterns, wells, etc.), settlement works (tunnels, bomb shelters, tombs etc.) and various works (quarries, natural caves, etc.). This paper describes the phases of the survey of a large cavity below a high-traffic square near the Faculty of Engineering in the city of Cagliari, where the research team works. The cave, which is part of a larger complex, is important because it was used in the thirteenth century (known as the Pisan age) as a stone quarry. There are traces of this activity that have to be protected. Moreover, during the last forty years the continuous crossover of vehicles cracked the roof of the cave compromising the stability of the entire area. Consequently a plan was developed to make the whole cavity safe and usable for visits. The study of the safety of the cave has involved different professionals among which geologists, engineers, constructors. The goal of the University of Cagliari geomatic team was to solve two problems: to obtain geometrical information about the void and correctly place the cave in the context of existing maps. The survey and the products, useful for the investigation of the technicians involved, had to comply with tolerances of 3 cm in the horizontal and 5 cm in the vertical component. The approach chosen for this purpose was to integrate different geomatic techniques. The cave was surveyed using a laser scanner (Faro Photon 80) in order to obtain a 3D model of the cave from which all the geometrical information was derived, while both classic topography and GPS techniques were used to include the cave in the

  19. Integrative gene transfer in the truffle Tuber borchii by Agrobacterium tumefaciens-mediated transformation

    PubMed Central

    2014-01-01

    Agrobacterium tumefaciens-mediated transformation is a powerful tool for reverse genetics and functional genomic analysis in a wide variety of plants and fungi. Tuber spp. are ecologically important and gastronomically prized fungi (“truffles”) with a cryptic life cycle, a subterranean habitat and a symbiotic, but also facultative saprophytic lifestyle. The genome of a representative member of this group of fungi has recently been sequenced. However, because of their poor genetic tractability, including transformation, truffles have so far eluded in-depth functional genomic investigations. Here we report that A. tumefaciens can infect Tuber borchii mycelia, thereby conveying its transfer DNA with the production of stably integrated transformants. We constructed two new binary plasmids (pABr1 and pABr3) and tested them as improved transformation vectors using the green fluorescent protein as reporter gene and hygromycin phosphotransferase as selection marker. Transformants were stable for at least 12 months of in vitro culture propagation and, as revealed by TAIL- PCR analysis, integration sites appear to be heterogeneous, with a preference for repeat element-containing genome sites. PMID:24949275

  20. Integrative gene transfer in the truffle Tuber borchii by Agrobacterium tumefaciens-mediated transformation.

    PubMed

    Brenna, Andrea; Montanini, Barbara; Muggiano, Eleonora; Proietto, Marco; Filetici, Patrizia; Ottonello, Simone; Ballario, Paola

    2014-01-01

    Agrobacterium tumefaciens-mediated transformation is a powerful tool for reverse genetics and functional genomic analysis in a wide variety of plants and fungi. Tuber spp. are ecologically important and gastronomically prized fungi ("truffles") with a cryptic life cycle, a subterranean habitat and a symbiotic, but also facultative saprophytic lifestyle. The genome of a representative member of this group of fungi has recently been sequenced. However, because of their poor genetic tractability, including transformation, truffles have so far eluded in-depth functional genomic investigations. Here we report that A. tumefaciens can infect Tuber borchii mycelia, thereby conveying its transfer DNA with the production of stably integrated transformants. We constructed two new binary plasmids (pABr1 and pABr3) and tested them as improved transformation vectors using the green fluorescent protein as reporter gene and hygromycin phosphotransferase as selection marker. Transformants were stable for at least 12 months of in vitro culture propagation and, as revealed by TAIL- PCR analysis, integration sites appear to be heterogeneous, with a preference for repeat element-containing genome sites.

  1. Single-resonance diffraction gratings for time-domain pulse transformations: integration of optical signals.

    PubMed

    Bykov, Dmitry A; Doskolovich, Leonid L; Soifer, Victor A

    2012-08-01

    A general transformation of the optical pulse envelope implemented by a single-resonance diffraction grating is studied. The particular cases considered include optical pulse integration and differentiation implemented by the grating in the Wood anomalies and the fractional integration and differentiation of order 1/2 implemented in the Rayleigh-Wood anomalies. The extraordinary-optical-transmission plasmonic gratings are shown to be well suited for the integration in the transmission. Diffraction gratings to perform the integration and semi-integration of optical pulses with temporal features in the picosecond range are designed. Numerical simulations based on the rigorous coupled-wave analysis of Maxwell's equations are in good agreement with presented theoretical analysis.

  2. Fourier transform infrared spectroscopy techniques for the analysis of drugs of abuse

    NASA Astrophysics Data System (ADS)

    Kalasinsky, Kathryn S.; Levine, Barry K.; Smith, Michael L.; Magluilo, Joseph J.; Schaefer, Teresa

    1994-01-01

    Cryogenic deposition techniques for Gas Chromatography/Fourier Transform Infrared (GC/FT-IR) can be successfully employed in urinalysis for drugs of abuse with detection limits comparable to those of the established Gas Chromatography/Mass Spectrometry (GC/MS) technique. The additional confidence of the data that infrared analysis can offer has been helpful in identifying ambiguous results, particularly, in the case of amphetamines where drugs of abuse can be confused with over-the-counter medications or naturally occurring amines. Hair analysis has been important in drug testing when adulteration of urine samples has been a question. Functional group mapping can further assist the analysis and track drug use versus time.

  3. Improved parallel solution techniques for the integral transport matrix method

    SciTech Connect

    Zerr, Robert J; Azmy, Yousry Y

    2010-11-23

    Alternative solution strategies to the parallel block Jacobi (PBJ) method for the solution of the global problem with the integral transport matrix method operators have been designed and tested. The most straightforward improvement to the Jacobi iterative method is the Gauss-Seidel alternative. The parallel red-black Gauss-Seidel (PGS) algorithm can improve on the number of iterations and reduce work per iteration by applying an alternating red-black color-set to the subdomains and assigning multiple sub-domains per processor. A parallel GMRES(m) method was implemented as an alternative to stationary iterations. Computational results show that the PGS method can improve on the PBJ method execution by up to {approx}50% when eight sub-domains per processor are used. However, compared to traditional source iterations with diffusion synthetic acceleration, it is still approximately an order of magnitude slower. The best-performing case are opticaUy thick because sub-domains decouple, yielding faster convergence. Further tests revealed that 64 sub-domains per processor was the best performing level of sub-domain division. An acceleration technique that improves the convergence rate would greatly improve the ITMM. The GMRES(m) method with a diagonal block preconditioner consumes approximately the same time as the PBJ solver but could be improved by an as yet undeveloped, more efficient preconditioner.

  4. High-contrast active cavitation imaging technique based on multiple bubble wavelet transform.

    PubMed

    Lu, Shukuan; Xu, Shanshan; Liu, Runna; Hu, Hong; Wan, Mingxi

    2016-08-01

    In this study, a unique method that combines the ultrafast active cavitation imaging technique with multiple bubble wavelet transform (MBWT) for improving cavitation detection contrast was presented. The bubble wavelet was constructed by the modified Keller-Miksis equation that considered the mutual effect among bubbles. A three-dimensional spatial model was applied to simulate the spatial distribution of multiple bubbles. The effects of four parameters on the signal-to-noise ratio (SNR) of cavitation images were evaluated, including the following: initial radii of bubbles, scale factor in the wavelet transform, number of bubbles, and the minimum inter-bubble distance. And the other two spatial models and cavitation bubble size distributions were introduced in the MBWT method. The results suggested that in the free-field experiments, the averaged SNR of images acquired by the MBWT method was improved by 7.16 ± 0.09 dB and 3.14 ± 0.14 dB compared with the values of images acquired by the B-mode and single bubble wavelet transform (SBWT) methods. In addition, in the tissue experiments, the averaged cavitation-to-tissue ratio of cavitation images acquired by the MBWT method was improved by 4.69 ± 0.25 dB and 1.74± 0.29 dB compared with that of images acquired by B-mode and SBWT methods.

  5. Automatic measure of the split in the second cardiac sound by using the wavelet transform technique.

    PubMed

    Debbal, S M; Bereksi-Reguig, F

    2007-03-01

    This paper is concerned with the identification and automatic measure of the split in the second heart sound (S2) of the phonocardiogram signal (PCGs) for normal or pathological case. The second heart sound S2 consists of two acoustic components A2 and P2, the former is due to the closure of the aortic valve and the latter is due to the closure of the pulmonary valve. The aortic valve usually closes before the pulmonary valve, introducing a time delay known as "split". A automatic technique based on the discrete wavelet transform (DWT) and the continuous wavelet transform (CWT) is developed in this paper to measure the split of the second cardiac sound (S2) for the normal and pathological cases of the PCG signals. To quantify the splitting, the two components in S2 (i.e. A2 and P2) are identified and, the delay between the two components can be estimated. It is shown that the wavelet transform can provide best information and features of the split of S2 and the major components (A2 and P2) and consequently aid in medical diagnosis.

  6. [A new automatic quasars recognition technique based on PCA and Hough transform].

    PubMed

    Huang, Ling-yun; Hu, Zhan-yi

    2003-02-01

    The main purpose of quasar recognition is to determine the observed quasar spectrum's redshift value. Previously the template of quasar rest frame in the literature was basically constructed based on astronomers' hypotheses. Due to the inaccuracy of such a template, it is hard to determine the redshift value by matching the observed quasar spectrum with the template directly. This paper's main contributions are two-fold: Firstly, the template in our paper is constructed by the principal component analysis (PCA) method from some selected spectra with known redshift values, hence the obtained template is more realistic. Secondly, a 2D standard Hough transform, rather than a 1D Hough transform, is used. This is because although only redshift needs to be determined in our system, based on our observations, the magnitude of emission peak is also changed, hence a new parameter, namely scale parameter, is also introduced to the Hough transform to enhance the reliability of the recognition. The experiments show that the proposed technique is workable and the correct recognition rate can reach about as high as 90%.

  7. Ontology for Transforming Geo-Spatial Data for Discovery and Integration of Scientific Data

    NASA Astrophysics Data System (ADS)

    Nguyen, L.; Chee, T.; Minnis, P.

    2013-12-01

    Discovery and access to geo-spatial scientific data across heterogeneous repositories and multi-discipline datasets can present challenges for scientist. We propose to build a workflow for transforming geo-spatial datasets into semantic environment by using relationships to describe the resource using OWL Web Ontology, RDF, and a proposed geo-spatial vocabulary. We will present methods for transforming traditional scientific dataset, use of a semantic repository, and querying using SPARQL to integrate and access datasets. This unique repository will enable discovery of scientific data by geospatial bound or other criteria.

  8. Pulse-driven LED circuit with transformer-based current balance technique

    NASA Astrophysics Data System (ADS)

    Kwak, S.-S.

    2014-12-01

    Light emitting diodes (LEDs) have been gradually used for backlight modules for liquid crystal display as a substitute for cold cathode fluorescent lamps. In most of LED applications, it is required to connect several LED strings in parallel to limit the dc voltage level to be applied to the single LED string. Due to considerable current variations through each LED string with inevitable parameter deviations as well as temperature and ageing effects, techniques to balance currents flowing through LED strings are required for LED drivers. This article proposes a pulse-driven LED circuit with transformer-based current balancing scheme, which can simply regulate currents through the LED strings. The transformers are placed in series with the LED strings in such a way that the LED currents are automatically balanced. Since the developed current sharing technique employs no dissipative resistors and no linear-mode transistors, the proposed driver has high efficiency, low power dissipation and reduced thermal problems. In addition, the presented driver with no additional semiconductor devices and no additional controllers can provide a simple and a cost-effective current balancing solution, compared to conventional approaches. Thus, the proposed LED driver can feature a simple, highly efficient, reliable and cost-effective method. The presented LED driver is verified with experimental results.

  9. Transformation as a Design Process and Runtime Architecture for High Integrity Software

    SciTech Connect

    Bespalko, S.J.; Winter, V.L.

    1999-04-05

    We have discussed two aspects of creating high integrity software that greatly benefit from the availability of transformation technology, which in this case is manifest by the requirement for a sophisticated backtracking parser. First, because of the potential for correctly manipulating programs via small changes, an automated non-procedural transformation system can be a valuable tool for constructing high assurance software. Second, modeling the processing of translating data into information as a, perhaps, context-dependent grammar leads to an efficient, compact implementation. From a practical perspective, the transformation process should begin in the domain language in which a problem is initially expressed. Thus in order for a transformation system to be practical it must be flexible with respect to domain-specific languages. We have argued that transformation applied to specification results in a highly reliable system. We also attempted to briefly demonstrate that transformation technology applied to the runtime environment will result in a safe and secure system. We thus believe that the sophisticated multi-lookahead backtracking parsing technology is central to the task of being in a position to demonstrate the existence of HIS.

  10. Integrated Personal Health Records: Transformative Tools for Consumer-Centric Care

    PubMed Central

    Detmer, Don; Bloomrosen, Meryl; Raymond, Brian; Tang, Paul

    2008-01-01

    Background Integrated personal health records (PHRs) offer significant potential to stimulate transformational changes in health care delivery and self-care by patients. In 2006, an invitational roundtable sponsored by Kaiser Permanente Institute, the American Medical Informatics Association, and the Agency for Healthcare Research and Quality was held to identify the transformative potential of PHRs, as well as barriers to realizing this potential and a framework for action to move them closer to the health care mainstream. This paper highlights and builds on the insights shared during the roundtable. Discussion While there is a spectrum of dominant PHR models, (standalone, tethered, integrated), the authors state that only the integrated model has true transformative potential to strengthen consumers' ability to manage their own health care. Integrated PHRs improve the quality, completeness, depth, and accessibility of health information provided by patients; enable facile communication between patients and providers; provide access to health knowledge for patients; ensure portability of medical records and other personal health information; and incorporate auto-population of content. Numerous factors impede widespread adoption of integrated PHRs: obstacles in the health care system/culture; issues of consumer confidence and trust; lack of technical standards for interoperability; lack of HIT infrastructure; the digital divide; uncertain value realization/ROI; and uncertain market demand. Recent efforts have led to progress on standards for integrated PHRs, and government agencies and private companies are offering different models to consumers, but substantial obstacles remain to be addressed. Immediate steps to advance integrated PHRs should include sharing existing knowledge and expanding knowledge about them, building on existing efforts, and continuing dialogue among public and private sector stakeholders. Summary Integrated PHRs promote active, ongoing

  11. Renal Graft Fibrosis and Inflammation Quantification by an Automated Fourier-Transform Infrared Imaging Technique.

    PubMed

    Vuiblet, Vincent; Fere, Michael; Gobinet, Cyril; Birembaut, Philippe; Piot, Olivier; Rieu, Philippe

    2016-08-01

    Renal interstitial fibrosis and interstitial active inflammation are the main histologic features of renal allograft biopsy specimens. Fibrosis is currently assessed by semiquantitative subjective analysis, and color image analysis has been developed to improve the reliability and repeatability of this evaluation. However, these techniques fail to distinguish fibrosis from constitutive collagen or active inflammation. We developed an automatic, reproducible Fourier-transform infrared (FTIR) imaging-based technique for simultaneous quantification of fibrosis and inflammation in renal allograft biopsy specimens. We generated and validated a classification model using 49 renal biopsy specimens and subsequently tested the robustness of this classification algorithm on 166 renal grafts. Finally, we explored the clinical relevance of fibrosis quantification using FTIR imaging by comparing results with renal function at 3 months after transplantation (M3) and the variation of renal function between M3 and M12. We showed excellent robustness for fibrosis and inflammation classification, with >90% of renal biopsy specimens adequately classified by FTIR imaging. Finally, fibrosis quantification by FTIR imaging correlated with renal function at M3, and the variation in fibrosis between M3 and M12 correlated well with the variation in renal function over the same period. This study shows that FTIR-based analysis of renal graft biopsy specimens is a reproducible and reliable label-free technique for quantifying fibrosis and active inflammation. This technique seems to be more relevant than digital image analysis and promising for both research studies and routine clinical practice.

  12. Renal Graft Fibrosis and Inflammation Quantification by an Automated Fourier-Transform Infrared Imaging Technique.

    PubMed

    Vuiblet, Vincent; Fere, Michael; Gobinet, Cyril; Birembaut, Philippe; Piot, Olivier; Rieu, Philippe

    2016-08-01

    Renal interstitial fibrosis and interstitial active inflammation are the main histologic features of renal allograft biopsy specimens. Fibrosis is currently assessed by semiquantitative subjective analysis, and color image analysis has been developed to improve the reliability and repeatability of this evaluation. However, these techniques fail to distinguish fibrosis from constitutive collagen or active inflammation. We developed an automatic, reproducible Fourier-transform infrared (FTIR) imaging-based technique for simultaneous quantification of fibrosis and inflammation in renal allograft biopsy specimens. We generated and validated a classification model using 49 renal biopsy specimens and subsequently tested the robustness of this classification algorithm on 166 renal grafts. Finally, we explored the clinical relevance of fibrosis quantification using FTIR imaging by comparing results with renal function at 3 months after transplantation (M3) and the variation of renal function between M3 and M12. We showed excellent robustness for fibrosis and inflammation classification, with >90% of renal biopsy specimens adequately classified by FTIR imaging. Finally, fibrosis quantification by FTIR imaging correlated with renal function at M3, and the variation in fibrosis between M3 and M12 correlated well with the variation in renal function over the same period. This study shows that FTIR-based analysis of renal graft biopsy specimens is a reproducible and reliable label-free technique for quantifying fibrosis and active inflammation. This technique seems to be more relevant than digital image analysis and promising for both research studies and routine clinical practice. PMID:26683669

  13. Esophageal Cancer Dose Escalation Using a Simultaneous Integrated Boost Technique

    SciTech Connect

    Welsh, James; Palmer, Matthew B.; Ajani, Jaffer A.; Liao Zhongxing; Swisher, Steven G.; Hofstetter, Wayne L.; Allen, Pamela K.; Settle, Steven H.; Gomez, Daniel; Likhacheva, Anna; Cox, James D.; Komaki, Ritsuko

    2012-01-01

    Purpose: We previously showed that 75% of radiation therapy (RT) failures in patients with unresectable esophageal cancer are in the gross tumor volume (GTV). We performed a planning study to evaluate if a simultaneous integrated boost (SIB) technique could selectively deliver a boost dose of radiation to the GTV in patients with esophageal cancer. Methods and Materials: Treatment plans were generated using four different approaches (two-dimensional conformal radiotherapy [2D-CRT] to 50.4 Gy, 2D-CRT to 64.8 Gy, intensity-modulated RT [IMRT] to 50.4 Gy, and SIB-IMRT to 64.8 Gy) and optimized for 10 patients with distal esophageal cancer. All plans were constructed to deliver the target dose in 28 fractions using heterogeneity corrections. Isodose distributions were evaluated for target coverage and normal tissue exposure. Results: The 50.4 Gy IMRT plan was associated with significant reductions in mean cardiac, pulmonary, and hepatic doses relative to the 50.4 Gy 2D-CRT plan. The 64.8 Gy SIB-IMRT plan produced a 28% increase in GTV dose and comparable normal tissue doses as the 50.4 Gy IMRT plan; compared with the 50.4 Gy 2D-CRT plan, the 64.8 Gy SIB-IMRT produced significant dose reductions to all critical structures (heart, lung, liver, and spinal cord). Conclusions: The use of SIB-IMRT allowed us to selectively increase the dose to the GTV, the area at highest risk of failure, while simultaneously reducing the dose to the normal heart, lung, and liver. Clinical implications warrant systematic evaluation.

  14. A generalized Clebsch transformation leading to a first integral of Navier-Stokes equations

    NASA Astrophysics Data System (ADS)

    Scholle, M.; Marner, F.

    2016-09-01

    In fluid dynamics, the Clebsch transformation allows for the construction of a first integral of the equations of motion leading to a self-adjoint form of the equations. A remarkable feature is the description of the vorticity by means of only two potential fields fulfilling simple transport equations. Despite useful applications in fluid dynamics and other physical disciplines as well, the classical Clebsch transformation has ever been restricted to inviscid flow. In the present paper a novel, generalized Clebsch transformation is developed which also covers the case of incompressible viscous flow. The resulting field equations are discussed briefly and solved for a flow example. Perspectives for a further extension of the method as well as perspectives towards the development of new solution strategies are presented.

  15. Mixed finite-difference/integral transform approach for parabolic-hyperbolic problems in transient forced convection

    SciTech Connect

    Cotta, R.M.; Gerk, J.E.V. . Dept. de Engenharia Mecanica)

    1994-06-01

    The integral transform method is employed in conjunction with second-order-accurate explicit finite-differences schemes, to handle accurately a class of parabolic-hyperbolic problems that appear in connection with transient forced convection inside ducts. The integral transformation process eliminates the independent variables in which the diffusion phenomena predominate. A system of coupled hyperbolic equations then results, involving time and the space coordinates in which convection is dominant, which is solved numerically through a modified upwind second-order finite-difference scheme. Stability and convergence characteristics of the proposed mixed approach are also examined. Typical applications in two- and three-dimensional geometries are considered, for both slug and laminar flow situations.

  16. Tensor Product Model Transformation Based Adaptive Integral-Sliding Mode Controller: Equivalent Control Method

    PubMed Central

    Zhao, Guoliang; Li, Hongxing

    2013-01-01

    This paper proposes new methodologies for the design of adaptive integral-sliding mode control. A tensor product model transformation based adaptive integral-sliding mode control law with respect to uncertainties and perturbations is studied, while upper bounds on the perturbations and uncertainties are assumed to be unknown. The advantage of proposed controllers consists in having a dynamical adaptive control gain to establish a sliding mode right at the beginning of the process. Gain dynamics ensure a reasonable adaptive gain with respect to the uncertainties. Finally, efficacy of the proposed controller is verified by simulations on an uncertain nonlinear system model. PMID:24453897

  17. Tensor product model transformation based adaptive integral-sliding mode controller: equivalent control method.

    PubMed

    Zhao, Guoliang; Sun, Kaibiao; Li, Hongxing

    2013-01-01

    This paper proposes new methodologies for the design of adaptive integral-sliding mode control. A tensor product model transformation based adaptive integral-sliding mode control law with respect to uncertainties and perturbations is studied, while upper bounds on the perturbations and uncertainties are assumed to be unknown. The advantage of proposed controllers consists in having a dynamical adaptive control gain to establish a sliding mode right at the beginning of the process. Gain dynamics ensure a reasonable adaptive gain with respect to the uncertainties. Finally, efficacy of the proposed controller is verified by simulations on an uncertain nonlinear system model.

  18. An integrating current transformer for fast extraction from the HIRFL-CSR main ring

    NASA Astrophysics Data System (ADS)

    Wu, Jun-Xia; Zheng, Jian-Hua; Zhao, Tie-Cheng; Mao, Rui-Shi; Yin, Yan; Yuan, You-Jin; Yang, Jian-Cheng

    2010-01-01

    For any experiment that uses the beam of an accelerator, monitoring the beam intensity is always an important concern. It is particularly useful if one can continuously measure the beam current without disturbing the beam. We report here on test experiments for an Integrating Current Transformer (ICT) used to measure fast extraction beams from the HIRFL-CSR main ring (CSRm). The laboratory tests and beam intensity measurement results are presented in this paper. The influence of the kicker noise is also analyzed.

  19. A Unified Method of Finding Laplace Transforms, Fourier Transforms, and Fourier Series. [and] An Inversion Method for Laplace Transforms, Fourier Transforms, and Fourier Series. Integral Transforms and Series Expansions. Modules and Monographs in Undergraduate Mathematics and Its Applications Project. UMAP Units 324 and 325.

    ERIC Educational Resources Information Center

    Grimm, C. A.

    This document contains two units that examine integral transforms and series expansions. In the first module, the user is expected to learn how to use the unified method presented to obtain Laplace transforms, Fourier transforms, complex Fourier series, real Fourier series, and half-range sine series for given piecewise continuous functions. In…

  20. Remote and terrestrial ground monitoring techniques integration for hazard assessment in mountain areas

    NASA Astrophysics Data System (ADS)

    Chinellato, Giulia; Kenner, Robert; Iasio, Christian; Mair, Volkmar; Mosna, David; Mulas, Marco; Phillips, Marcia; Strada, Claudia; Zischg, Andreas

    2014-05-01

    In high mountain regions the choice of appropriate sites for infrastructure such as roads, railways, cable cars or hydropower dams is often very limited. In parallel, the increasing demand for supply infrastructure in the Alps induces a continuous transformation of the territory. The new role played by the precautionary monitoring in the risk governance becomes fundamental and may overcome the modeling of future events, which represented so far the predominant approach to these sort of issues. Furthermore the consequence of considering methodologies alternative to those more exclusive allow to reduce costs and increasing the frequency of measurements, updating continuously the cognitive framework of existing hazard condition in most susceptible territories. The scale factor of the observed area and the multiple purpose of such regional ordinary surveys make it convenient to adopt Radar Satellite-based systems, but they need to be integrated with terrestrial systems for validation and eventual early warning purposes. Significant progress over the past decade in Remote Sensing (RS), Proximal Sensing and integration-based sensor networks systems now provide technologies, that allow to implement monitoring systems for ordinary surveys of extensive areas or regions, which are affected by active natural processes and slope instability. The Interreg project SloMove aims to provide solutions for such challenges and focuses on using remote sensing monitoring techniques for the monitoring of mass movements in two test sites, in South Tyrol (Italy) and in Grisons Canton (Switzerland). The topics faced in this project concern mass movements and slope deformation monitoring techniques, focusing mainly on the integration of multi-temporal interferometry, new generation of terrestrial technologies for differential digital terrain model elaboration provided by laser scanner (TLS), and GNSS-based topographic surveys, which are used not only for validation purpose, but also for

  1. High-contrast active cavitation imaging technique based on multiple bubble wavelet transform.

    PubMed

    Lu, Shukuan; Xu, Shanshan; Liu, Runna; Hu, Hong; Wan, Mingxi

    2016-08-01

    In this study, a unique method that combines the ultrafast active cavitation imaging technique with multiple bubble wavelet transform (MBWT) for improving cavitation detection contrast was presented. The bubble wavelet was constructed by the modified Keller-Miksis equation that considered the mutual effect among bubbles. A three-dimensional spatial model was applied to simulate the spatial distribution of multiple bubbles. The effects of four parameters on the signal-to-noise ratio (SNR) of cavitation images were evaluated, including the following: initial radii of bubbles, scale factor in the wavelet transform, number of bubbles, and the minimum inter-bubble distance. And the other two spatial models and cavitation bubble size distributions were introduced in the MBWT method. The results suggested that in the free-field experiments, the averaged SNR of images acquired by the MBWT method was improved by 7.16 ± 0.09 dB and 3.14 ± 0.14 dB compared with the values of images acquired by the B-mode and single bubble wavelet transform (SBWT) methods. In addition, in the tissue experiments, the averaged cavitation-to-tissue ratio of cavitation images acquired by the MBWT method was improved by 4.69 ± 0.25 dB and 1.74± 0.29 dB compared with that of images acquired by B-mode and SBWT methods. PMID:27586732

  2. Measurements of solar magnetic fields by Fourier transform techniques. II - Saturated and blended lines

    NASA Technical Reports Server (NTRS)

    Tarbell, T. D.; Title, A. M.

    1976-01-01

    Fourier techniques have been exhaustively calibrated using Unno's (1956) results for the absorption profile of a simple Zeeman triplet. If a simple transformation is applied to the normalized line depths, then magnetic-field strengths and inclination angles can be measured very accurately from noisy saturated line profiles. Systematic errors caused by saturation effects can be estimated and reduced by varying one parameter. When a significant fraction of the line profile is unsplit and unpolarized, large errors may be made in measurements of low fields, unless the line is sufficiently weak. For a weak line, a vertical field of 1600 gauss can be measured to 10% accuracy even when 70% of the line profile is stray light. These stray-light errors are troublesome in measuring fields of gaps and pores but not sunspots. Numerical results of the error analysis are presented graphically.

  3. Prepreg cure monitoring using diffuse reflectance-FTIR. [Fourier Transform Infrared Technique

    NASA Technical Reports Server (NTRS)

    Young, P. R.; Chang, A. C.

    1984-01-01

    An in situ diffuse reflectance-Fourier transform infrared technique was developed to determine infrared spectra of graphite fiber prepregs as they were being cured. A bismaleimide, an epoxy, and addition polyimide matrix resin prepregs were studied. An experimental polyimide adhesive was also examined. Samples were positioned on a small heater at the focal point of diffuse reflectance optics and programmed at 15 F/min while FTIR spectra were being scanned, averaged, and stored. An analysis of the resulting spectra provided basic insights into changes in matrix resin molecular structure which accompanied reactions such as imidization and crosslinking. An endo-exothermal isomerization involving reactive end-caps was confirmed for the addition polyimide prepregs. The results of this study contribute to a fundamental understanding of the processing of composites and adhesives. Such understanding will promote the development of more efficient cure cycles.

  4. Integrating Literature in Mathematics: A Teaching Technique for Mathematics Teachers

    ERIC Educational Resources Information Center

    Ruiz, Elsa C.; Thornton, Jenifer Salter; Cuero, Kimberley K.

    2010-01-01

    The integration of content areas is not a new concept (Moyer, 2000). Integration is promoted by many teacher educators because of its benefits for learners of all ages and backgrounds (Burns, 2005; Douville, Pugalee, & Wallace, 2003; Pica, 2002). Literacy in general, but reading in particular, is important across the content areas. Mathematics…

  5. Efficient local statistical analysis via integral histograms with discrete wavelet transform.

    PubMed

    Lee, Teng-Yok; Shen, Han-Wei

    2013-12-01

    Histograms computed from local regions are commonly used in many visualization applications, and allowing the user to query histograms interactively in regions of arbitrary locations and sizes plays an important role in feature identification and tracking. Computing histograms in regions with arbitrary location and size, nevertheless, can be time consuming for large data sets since it involves expensive I/O and scan of data elements. To achieve both performance- and storage-efficient query of local histograms, we present a new algorithm called WaveletSAT, which utilizes integral histograms, an extension of the summed area tables (SAT), and discrete wavelet transform (DWT). Similar to SAT, an integral histogram is the histogram computed from the area between each grid point and the grid origin, which can be be pre-computed to support fast query. Nevertheless, because one histogram contains multiple bins, it will be very expensive to store one integral histogram at each grid point. To reduce the storage cost for large integral histograms, WaveletSAT treats the integral histograms of all grid points as multiple SATs, each of which can be converted into a sparse representation via DWT, allowing the reconstruction of axis-aligned region histograms of arbitrary sizes from a limited number of wavelet coefficients. Besides, we present an efficient wavelet transform algorithm for SATs that can operate on each grid point separately in logarithmic time complexity, which can be extended to parallel GPU-based implementation. With theoretical and empirical demonstration, we show that WaveletSAT can achieve fast preprocessing and smaller storage overhead than the conventional integral histogram approach with close query performance. PMID:24051836

  6. Studies on Nephrite and Jadeite Jades by Fourier Transform Infrared (ftir) and Raman Spectroscopic Techniques

    NASA Astrophysics Data System (ADS)

    Tan, T. L.; Ng, L. L.; Lim, L. C.

    2013-10-01

    The mineralogical properties of black nephrite jade from Western Australia are studied by Fourier transform infrared (FTIR) spectroscopy using both transmission and specular reflectance techniques in the 4000-400 cm-1 wavenumber region. The infrared absorption peaks in the 3700-3600 cm-1 region which are due to the O-H stretching mode provides a quantitative analysis of the Fe/(Fe+Mg) ratio in the mineral composition of jade samples. The Fe/(Fe+Mg) percentage in black nephrite is found to be higher than that in green nephrite, but comparable to that of actinolite (iron-rich nephrite). This implies that the mineralogy of black nephrite is closer to actinolite than tremolite. The jade is also characterized using Raman spectroscopy in the 1200-200 cm-1 region. Results from FTIR and Raman spectroscopic data of black nephrite jade are compared with those of green nephrite jade from New Zealand and jadeite jade from Myanmar. Black nephrite appears to have a slightly different chemical composition from green nephrite. Spectra from FTIR and Raman spectroscopic techniques were found to be useful in differentiating black nephrite, green nephrite, and green jadeite jades. Furthermore, data on refractive index, specific gravity, and hardness of black nephrite jade are measured and compared with those of green nephrite and of jadeite jade.

  7. Performance of an HDTV codec adopting transform and motion compensation techniques

    NASA Astrophysics Data System (ADS)

    Barbero, Marzio; Cucchi, Silvio; Muratori, Mario

    1991-12-01

    Digital techniques are widely adopted to process the video signal, and nowadays there is the necessity of transmitting conventional and high-definition television signals between different studios. In the near future it could be possible to deliver a digital signal to the consumer. To allow the use of the presently available digital networks and satellites, sophisticated compression techniques have been devised to limit the bit-rate requirements and to provide a high-quality and reliable service. A hybrid predictive/transform system has been devised and implemented in the framework of the European project EU 256. The main parameters of this system are in accordance with those being recommended by ETSI and CMTT for the transmission of conventional component TV. Codecs are available for the TV and HDTV formats presently in use and can operate with a wide range of transmission rates. The optimization of the system and the evaluation of its performance have been carried out on the basis of a large number of subjective tests in accordance with the user requirements specified by the standardization bodies. The codecs have been extensively tested on-field during experimental point-to-multipoint satellite transmission of HDTV signals on the occasion of soccer matches.

  8. Estimation of petrophysical and fluid properties using integral transforms in nuclear magnetic resonance.

    PubMed

    Gruber, Fred K; Venkataramanan, Lalitha; Habashy, Tarek M; Freed, Denise E

    2013-03-01

    In the past decade, low-field NMR relaxation and diffusion measurements in grossly inhomogeneous fields have been used to characterize properties of porous media, e.g., porosity and permeability. Pulse sequences such as CPMG, inversion and saturation recovery as well as diffusion editing have been used to estimate distribution functions of relaxation times and diffusion. Linear functionals of these distribution functions have been used to predict petro-physical and fluid properties like permeability, viscosity, fluid typing, etc. This paper describes an analysis method using integral transforms to directly compute linear functionals of the distributions of relaxation times and diffusion without first computing the distributions from the measured magnetization data. Different linear functionals of the distribution function can be obtained by choosing appropriate kernels in the integral transforms. There are two significant advantages of this approach over the traditional algorithm involving inversion of the distribution function from the measured data. First, it is a direct linear transform of the data. Thus, in contrast to the traditional analysis which involves inversion of an ill-conditioned, non-linear problem, the estimates from this new method are more accurate. Second, the uncertainty in the linear functional can be obtained in a straight-forward manner as a function of the signal-to-noise ratio (SNR) in the measured data. We demonstrate the performance of this method on simulated data. PMID:23369701

  9. Transformation of Chloroplast Ribosomal RNA Genes in Chlamydomonas: Molecular and Genetic Characterization of Integration Events

    PubMed Central

    Newman, S. M.; Boynton, J. E.; Gillham, N. W.; Randolph-Anderson, B. L.; Johnson, A. M.; Harris, E. H.

    1990-01-01

    Transformation of chloroplast ribosomal RNA (rRNA) genes in Chlamydomonas has been achieved by the biolistic process using cloned chloroplast DNA fragments carrying mutations that confer antibiotic resistance. The sites of exchange employed during the integration of the donor DNA into the recipient genome have been localized using a combination of antibiotic resistance mutations in the 16S and 23S rRNA genes and restriction fragment length polymorphisms that flank these genes. Complete or nearly complete replacement of a region of the chloroplast genome in the recipient cell by the corresponding sequence from the donor plasmid was the most common integration event. Exchange events between the homologous donor and recipient sequences occurred preferentially near the vector:insert junctions. Insertion of the donor rRNA genes and flanking sequences into one inverted repeat of the recipient genome was followed by intramolecular copy correction so that both copies of the inverted repeat acquired identical sequences. Increased frequencies of rRNA gene transformants were achieved by reducing the copy number of the chloroplast genome in the recipient cells and by decreasing the heterology between donor and recipient DNA sequences flanking the selectable markers. In addition to producing bona fide chloroplast rRNA transformants, the biolistic process induced mutants resistant to low levels of streptomycin, typical of nuclear mutations in Chlamydomonas. PMID:1981764

  10. NitroScape: a model to integrate nitrogen transfers and transformations in rural landscapes.

    PubMed

    Duretz, S; Drouet, J L; Durand, P; Hutchings, N J; Theobald, M R; Salmon-Monviola, J; Dragosits, U; Maury, O; Sutton, M A; Cellier, P

    2011-11-01

    Modelling nitrogen transfer and transformation at the landscape scale is relevant to estimate the mobility of the reactive forms of nitrogen (N(r)) and the associated threats to the environment. Here we describe the development of a spatially and temporally explicit model to integrate N(r) transfer and transformation at the landscape scale. The model couples four existing models, to simulate atmospheric, farm, agro-ecosystem and hydrological N(r) fluxes and transformations within a landscape. Simulations were carried out on a theoretical landscape consisting of pig-crop farms interspersed with unmanaged ecosystems. Simulation results illustrated the effect of spatial interactions between landscape elements on N(r) fluxes and losses to the environment. More than 10% of the total N(2)O emissions were due to indirect emissions. The nitrogen budgets and transformations of the unmanaged ecosystems varied considerably, depending on their location within the landscape. The model represents a new tool for assessing the effect of changes in landscape structure on N(r) fluxes.

  11. Improving protein identification using complementary fragmentation techniques in fourier transform mass spectrometry.

    PubMed

    Nielsen, Michael L; Savitski, Mikhail M; Zubarev, Roman A

    2005-06-01

    Identification of proteins by MS/MS is performed by matching experimental mass spectra against calculated spectra of all possible peptides in a protein data base. The search engine assigns each spectrum a score indicating how well the experimental data complies with the expected one; a higher score means increased confidence in the identification. One problem is the false-positive identifications, which arise from incomplete data as well as from the presence of misleading ions in experimental mass spectra due to gas-phase reactions, stray ions, contaminants, and electronic noise. We employed a novel technique of reduction of false positives that is based on a combined use of orthogonal fragmentation techniques electron capture dissociation (ECD) and collisionally activated dissociation (CAD). Since ECD and CAD exhibit many complementary properties, their combined use greatly increased the analysis specificity, which was further strengthened by the high mass accuracy (approximately 1 ppm) afforded by Fourier transform mass spectrometry. The utility of this approach is demonstrated on a whole cell lysate from Escherichia coli. Analysis was made using the data-dependent acquisition mode. Extraction of complementary sequence information was performed prior to data base search using in-house written software. Only masses involved in complementary pairs in the MS/MS spectrum from the same or orthogonal fragmentation techniques were submitted to the data base search. ECD/CAD identified twice as many proteins at a fixed statistically significant confidence level with on average a 64% higher Mascot score. The confidence in protein identification was hereby increased by more than 1 order of magnitude. The combined ECD/CAD searches were on average 20% faster than CAD-only searches. A specially developed test with scrambled MS/MS data revealed that the amount of false-positive identifications was dramatically reduced by the combined use of CAD and ECD.

  12. Self-Consistent Sources for Integrable Equations Via Deformations of Binary Darboux Transformations

    NASA Astrophysics Data System (ADS)

    Chvartatskyi, Oleksandr; Dimakis, Aristophanes; Müller-Hoissen, Folkert

    2016-08-01

    We reveal the origin and structure of self-consistent source extensions of integrable equations from the perspective of binary Darboux transformations. They arise via a deformation of the potential that is central in this method. As examples, we obtain in particular matrix versions of self-consistent source extensions of the KdV, Boussinesq, sine-Gordon, nonlinear Schrödinger, KP, Davey-Stewartson, two-dimensional Toda lattice and discrete KP equation. We also recover a (2+1)-dimensional version of the Yajima-Oikawa system from a deformation of the pKP hierarchy. By construction, these systems are accompanied by a hetero binary Darboux transformation, which generates solutions of such a system from a solution of the source-free system and additionally solutions of an associated linear system and its adjoint. The essence of all this is encoded in universal equations in the framework of bidifferential calculus.

  13. Regularization of Motion Equations with L-Transformation and Numerical Integration of the Regular Equations

    NASA Astrophysics Data System (ADS)

    Poleshchikov, Sergei M.

    2003-04-01

    The sets of L-matrices of the second, fourth and eighth orders are constructed axiomatically. The defining relations are taken from the regularization of motion equations for Keplerian problem. In particular, the Levi-Civita matrix and KS-matrix are L-matrices of second and fourth order, respectively. A theorem on the ranks of L-transformations of different orders is proved. The notion of L-similarity transformation is introduced, certain sets of L-matrices are constructed, and their classification is given. An application of fourth order L-matrices for N-body problem regularization is given. A method of correction for regular coordinates in the Runge-Kutta-Fehlberg integration method for regular motion equations of a perturbed two-body problem is suggested. Comparison is given for the results of numerical integration in the problem of defining the orbit of a satellite, with and without the above correction method. The comparison is carried out with respect to the number of calls to the subroutine evaluating the perturbational accelerations vector. The results of integration using the correction turn out to be in a favorable position.

  14. Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique.

    PubMed

    Phaechamud, Thawatchai; Tuntarawongsa, Sarun

    2016-01-01

    Eutectic solvent can solubilize high amount of some therapeutic compounds. Volatile eutectic solvent is interesting to be used as solvent in the preparation of nanosuspension with emulsion solvent evaporation technique. The mechanism of transformation from the eutectic emulsion to nanosuspension was investigated in this study. The 30% w/w ibuprofen eutectic solution was used as the internal phase, and the external phase is composed of Tween 80 as emulsifier. Ibuprofen nanosuspension was prepared by eutectic emulsion solvent evaporating method followed with ultrasonication. During evaporation process, the ibuprofen concentration in emulsion droplets was increased leading to a drug supersaturation but did not immediately recrystallize because of low glass transition temperature (T g) of ibuprofen. The contact angle of the internal phase on ibuprofen was apparently lower than that of the external phase at all times of evaporation, indicating that the ibuprofen crystals were preferentially wetted by the internal phase than the external phase. From calculated dewetting value ibuprofen crystallization occurred in the droplet. Crystallization of the drug was initiated with external mechanical force, and the particle size of the drug was larger due to Ostwald ripening. Cavitation force from ultrasonication minimized the ibuprofen crystals to the nanoscale. Particle size and zeta potential of formulated ibuprofen nanosuspension were 330.87±51.49 nm and -31.1±1.6 mV, respectively, and exhibited a fast dissolution. Therefore, the combination of eutectic emulsion solvent evaporation method with ultrasonication was favorable for fabricating an ibuprofen nanosuspension, and the transformation mechanism was attained successfully. PMID:27366064

  15. Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique

    PubMed Central

    Phaechamud, Thawatchai; Tuntarawongsa, Sarun

    2016-01-01

    Eutectic solvent can solubilize high amount of some therapeutic compounds. Volatile eutectic solvent is interesting to be used as solvent in the preparation of nanosuspension with emulsion solvent evaporation technique. The mechanism of transformation from the eutectic emulsion to nanosuspension was investigated in this study. The 30% w/w ibuprofen eutectic solution was used as the internal phase, and the external phase is composed of Tween 80 as emulsifier. Ibuprofen nanosuspension was prepared by eutectic emulsion solvent evaporating method followed with ultrasonication. During evaporation process, the ibuprofen concentration in emulsion droplets was increased leading to a drug supersaturation but did not immediately recrystallize because of low glass transition temperature (Tg) of ibuprofen. The contact angle of the internal phase on ibuprofen was apparently lower than that of the external phase at all times of evaporation, indicating that the ibuprofen crystals were preferentially wetted by the internal phase than the external phase. From calculated dewetting value ibuprofen crystallization occurred in the droplet. Crystallization of the drug was initiated with external mechanical force, and the particle size of the drug was larger due to Ostwald ripening. Cavitation force from ultrasonication minimized the ibuprofen crystals to the nanoscale. Particle size and zeta potential of formulated ibuprofen nanosuspension were 330.87±51.49 nm and −31.1±1.6 mV, respectively, and exhibited a fast dissolution. Therefore, the combination of eutectic emulsion solvent evaporation method with ultrasonication was favorable for fabricating an ibuprofen nanosuspension, and the transformation mechanism was attained successfully. PMID:27366064

  16. Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique.

    PubMed

    Phaechamud, Thawatchai; Tuntarawongsa, Sarun

    2016-01-01

    Eutectic solvent can solubilize high amount of some therapeutic compounds. Volatile eutectic solvent is interesting to be used as solvent in the preparation of nanosuspension with emulsion solvent evaporation technique. The mechanism of transformation from the eutectic emulsion to nanosuspension was investigated in this study. The 30% w/w ibuprofen eutectic solution was used as the internal phase, and the external phase is composed of Tween 80 as emulsifier. Ibuprofen nanosuspension was prepared by eutectic emulsion solvent evaporating method followed with ultrasonication. During evaporation process, the ibuprofen concentration in emulsion droplets was increased leading to a drug supersaturation but did not immediately recrystallize because of low glass transition temperature (T g) of ibuprofen. The contact angle of the internal phase on ibuprofen was apparently lower than that of the external phase at all times of evaporation, indicating that the ibuprofen crystals were preferentially wetted by the internal phase than the external phase. From calculated dewetting value ibuprofen crystallization occurred in the droplet. Crystallization of the drug was initiated with external mechanical force, and the particle size of the drug was larger due to Ostwald ripening. Cavitation force from ultrasonication minimized the ibuprofen crystals to the nanoscale. Particle size and zeta potential of formulated ibuprofen nanosuspension were 330.87±51.49 nm and -31.1±1.6 mV, respectively, and exhibited a fast dissolution. Therefore, the combination of eutectic emulsion solvent evaporation method with ultrasonication was favorable for fabricating an ibuprofen nanosuspension, and the transformation mechanism was attained successfully.

  17. Direct comparison of unloading compliance and potential drop techniques in J-integral testing

    SciTech Connect

    McGowan, J.J.; Nanstad, R.K.

    1984-01-01

    Single-specimen J-integral testing is performed commonly with the unloading compliance technique. Use of modern instrumentation techniques and powerful desktop computers have made this technique a standard. However, this testing technique is slow and tedious, with the loading rate fixed at a slow quasi-static rate. For these reasons the dc potential drop technique was investigated for crack length measurement during a J-integral test. For direct comparison, both unloading compliance and potential drop were used simultaneously during a J-integral test. The results showed good agreement between the techniques. However, the potential drop technique showed an offset in crack length due to plastic blunting processes. Taking this offset into account, J/sub Ic/ values calculated by both techniques compared well.

  18. Improved synthetic aperture focusing technique by Hilbert-Huang transform for imaging defects inside a concrete structure.

    PubMed

    Tong, Jian-Hua; Chiu, Chin-Lung; Wang, Chung-Yue

    2010-11-01

    A useful nondestructive testing tool for civil engineering should immediately reveal defects inside concrete structures at the construction sites. To date, there are few effective methods to image defects inside concrete structures. In this paper, a new nondestructive testing method using elastic waves for imaging possible defects inside concrete is developed. This method integrates the point-source/point receiver scheme with the synthetic aperture focusing technique (SAFT) to increase functioning depth and enhance received signals. To improve image quality, received signals are processed by Hilbert-Huang transform (HHT) to get time-frequency curves for the SAFT process. Compared with conventional SAFT method processing with time-amplitude signals, this new method is capable of providing a better image of defects not only in the numerical simulation but also in the experimental result. The image can reveal the number of defects and their locations and front-end profiles. The results shown in this paper indicate that this new elastic-wave-based method exhibits high capability in imaging the defects of in situ concrete structures.

  19. Development of Improved Caprock Integrity and Risk Assessment Techniques

    SciTech Connect

    Bruno, Michael

    2014-09-30

    GeoMechanics Technologies has completed a geomechanical caprock integrity analysis and risk assessment study funded through the US Department of Energy. The project included: a detailed review of historical caprock integrity problems experienced in the natural gas storage industry; a theoretical description and documentation of caprock integrity issues; advanced coupled transport flow modelling and geomechanical simulation of three large-scale potential geologic sequestration sites to estimate geomechanical effects from CO₂ injection; development of a quantitative risk and decision analysis tool to assess caprock integrity risks; and, ultimately the development of recommendations and guidelines for caprock characterization and CO₂ injection operating practices. Historical data from gas storage operations and CO₂ sequestration projects suggest that leakage and containment incident risks are on the order of 10-1 to 10-2, which is higher risk than some previous studies have suggested for CO₂. Geomechanical analysis, as described herein, can be applied to quantify risks and to provide operating guidelines to reduce risks. The risk assessment tool developed for this project has been applied to five areas: The Wilmington Graben offshore Southern California, Kevin Dome in Montana, the Louden Field in Illinois, the Sleipner CO₂ sequestration operation in the North Sea, and the In Salah CO₂ sequestration operation in North Africa. Of these five, the Wilmington Graben area represents the highest relative risk while the Kevin Dome area represents the lowest relative risk.

  20. Integrated transformations of plant biomass to valuable chemicals, biodegradable polymers and nanoporous carbons

    NASA Astrophysics Data System (ADS)

    Kuznetsov, B. N.; Chesnokov, N. V.; Taraban'ko, V. E.; Kuznetsova, S. A.; Petrov, A. V.

    2013-03-01

    Integrated transformations of wood biomass to valuable chemicals and materials are described. They include the main biomass components separation, the conversion of cellulose to glucose, levulinic acid, biodegradable polymers and lignin - to nanoporous carbons. For wood fractionation on pure cellulose and low molecular mass lignin the methods of catalytic oxidation and exploded autohydrolysis are used. The processes of acid-catalysed hydrolysis of cellulose to glucose and levulinic acid were optimized. New methods of biodegradable polymers synthesis from lactone of levulinic acid and nanoporous carbons from lignin were suggested.

  1. Large-scale, white-light, transformation optics using integral imaging

    NASA Astrophysics Data System (ADS)

    Oxburgh, Stephen; White, Chris D.; Antoniou, Georgios; Orife, Ejovbokoghene; Sharpe, Tim; Courtial, Johannes

    2016-04-01

    We describe a way to realise transformation-optical devices from structures of micro-structured sheets called generalised confocal lenslet arrays. The resulting devices should work for all visible light, and they should be relatively easy and cheap to (mass-)produce on the scale of metres, but they suffer from field-of-view limitations and significant transmission loss. Furthermore, the mapping between electromagnetic space and physical space is not through stigmatic imaging, but integral imaging. As an example application of this technology, we design and simulate an architectural window that cloaks insulation material with the aim of reducing heat loss.

  2. Calibration and integrity verification techniques applied to GPS simulators

    NASA Astrophysics Data System (ADS)

    Stulken, D. A.

    Automated calibration and signal verification techniques which are used in GPS simulators to ensure a high level of fidelity of the test stimulus employed in evaluating the performance of GPS receivers have been developed. The present techniques involve satellite signal power levels, jammer signal power levels, time of arrival of satellite signals, and the coordinated timing of simulated satellite signals with respect to the simulation of the host vehicle interface signals. From initial simulation and evaluation system design efforts, a new family of GPS RF signal generators were developed, the multiple channel signal generator and the single channel signal generator.

  3. Integrating Positive Psychology Techniques into Rehabilitation Counselor Education

    ERIC Educational Resources Information Center

    Chapin, Martha H.; Boykin, Rebecca B.

    2010-01-01

    Positive psychology offers rehabilitation counselor educators a framework to help students evaluate their own competencies and understand the value of a strengths-based approach to rehabilitation counseling. This article reviews several positive psychology techniques and discusses recommended uses as well as their effectiveness. Positive…

  4. Transient water age distributions in environmental flow systems: The time-marching Laplace transform solution technique

    NASA Astrophysics Data System (ADS)

    Cornaton, F. J.

    2012-03-01

    Environmental fluid circulations are very often characterized by analyzing the fate and behavior of natural and anthropogenic tracers. Among these tracers, age is taken as an ideal tracer which can yield interesting diagnoses, as for example the characterization of the mixing and renewal of water masses, of the fate and mixing of contaminants, or the calibration of hydrodispersive parameters used by numerical models. Such diagnoses are of great interest in atmospheric and ocean circulation sciences, as well in surface and subsurface hydrology. The temporal evolution of groundwater age and its frequency distributions can display important changes as flow regimes vary due to natural change in climate and hydrologic conditions and/or human induced pressures on the resource to satisfy the water demand. Groundwater age being nowadays frequently used to investigate reservoir properties and recharge conditions, special attention needs to be put on the way this property is characterized, would it be using isotopic methods or mathematical modeling. Steady state age frequency distributions can be modeled using standard numerical techniques since the general balance equation describing age transport under steady state flow conditions is exactly equivalent to a standard advection-dispersion equation. The time-dependent problem is however described by an extended transport operator that incorporates an additional coordinate for water age. The consequence is that numerical solutions can hardly be achieved, especially for real 3-D applications over large time periods of interest. A novel algorithm for solving the age distribution problem under time-varying flow regimes is presented and, for some specific configurations, extended to the problem of generalized component exposure time. The algorithm combines the Laplace transform technique applied to the age (or exposure time) coordinate with standard time-marching schemes. The method is validated and illustrated using analytical

  5. The unified transform for linear, linearizable and integrable nonlinear partial differential equations

    NASA Astrophysics Data System (ADS)

    Fokas, A. S.; De Lillo, S.

    2014-03-01

    So-called inverse scattering provides a powerful method for analyzing the initial value problem for a large class of nonlinear evolution partial differential equations which are called integrable. In the late 1990s, the first author, motivated by inverse scattering, introduced a new method for analyzing boundary value problems. This method provides a unified treatment for linear, linearizable and integrable nonlinear partial differential equations. Here, this method, which is often referred to as the unified transform, is illustrated for the following concrete cases: the heat equation on the half-line; the nonlinear Schrödinger equation on the half-line; Burger's equation on the half-line; and Burger's equation on a moving boundary.

  6. Research on the technique of public watermarking system based on wavelet transform and neural network

    NASA Astrophysics Data System (ADS)

    Xu, Li; Tao, Gu

    2007-04-01

    A hybrid algorithm of using a wavelet transform and a neural network is presented which solves the problems confronted in public watermarking systems. First, to get the wavelet coefficients, db1 wavelet is used to decompose the selected image. Second, to ensure better quality of the watermarked image, some wavelet coefficients and their closely relevant wavelet coefficients are randomly selected from the wavelet coefficients decomposed by the low pass filter and used to establish the relational model by using a neural network. Third, the bit information of the watermark is also enlarged by increasing the amount of zeros or ones and then one bit of the results is embedded by adjusting the polarity between a chosen wavelet coefficient and the output value of the model. Finally, a new image with watermark information is reconstructed by using the modified wavelet coefficients and other unmodified wavelet coefficients. On the other hand, the process of retrieving the watermark is the inverse of the embedding process. The embedded watermark can also be retrieved by using the hybrid algorithm and the restore function without knowing the original image and watermark. Experimental results show that the proposed technique is very robust against some image processing operations and JPEG lossy compression. Meanwhile, the extracted watermark can be proved by the proposed method. Because of the neural network, the proposed method is also robust against attack of false authentication. Therefore, the hybrid algorithm can be used to protect the copyright of one important image.

  7. Von mises- and crocco-type hydrodynamical transformations: Order reduction of nonlinear equations, construction of Bäcklund transformations and of new integrable equations

    NASA Astrophysics Data System (ADS)

    Fedotov, I. A.; Polyanin, A. D.

    2011-09-01

    Broad classes of nonlinear equations of mathematical physics are described that admit order reduction by applying the von Mises transformation (with the unknown function used as a new independent variable and with a suitable partial derivative used as a new dependent variable) and by applying the Crocco transformation (with the first and second partial derivatives used as new independent and dependent variables, respectively). Associated Bäcklund transformations are constructed that connect evolution equations of general form (their special cases include Burgers, Korteweg-de Vries, and Harry Dym type equations and many other nonlinear equations of mathematical physics). Transformations are indicated that reduce the order of hydrodynamic-type equations of higher orders. The generalized Calogero equation and a number of other new integrable nonlinear equations, reducible to linear equations, are considered.

  8. Process sequence optimization for digital microfluidic integration using EWOD technique

    NASA Astrophysics Data System (ADS)

    Yadav, Supriya; Joyce, Robin; Sharma, Akash Kumar; Sharma, Himani; Sharma, Niti Nipun; Varghese, Soney; Akhtar, Jamil

    2016-04-01

    Micro/nano-fluidic MEMS biosensors are the devices that detects the biomolecules. The emerging micro/nano-fluidic devices provide high throughput and high repeatability with very low response time and reduced device cost as compared to traditional devices. This article presents the experimental details for process sequence optimization of digital microfluidics (DMF) using "electrowetting-on-dielectric" (EWOD). Stress free thick film deposition of silicon dioxide using PECVD and subsequent process for EWOD techniques have been optimized in this work.

  9. Detecting transforming growth factor-β release from liver cells using an aptasensor integrated with microfluidics.

    PubMed

    Matharu, Zimple; Patel, Dipali; Gao, Yandong; Haque, Amranul; Zhou, Qing; Revzin, Alexander

    2014-09-01

    We developed a cell-culture/biosensor platform consisting of aptamer-modified Au electrodes integrated with reconfigurable microfluidics for monitoring of transforming growth factor-beta 1 (TGF-β1), an important inflammatory and pro-fibrotic cytokine. Aptamers were thiolated, labeled with redox reporters, and self-assembled on gold surfaces. The biosensor was determined to be specific for TGF-β1 with an experimental detection limit of 1 ng/mL and linear range extending to 250 ng/mL. Upon determining figures of merit, aptasensor was miniaturized and integrated with human hepatic stellate cells inside microfluidic devices. Reconfigurable microfluidics were developed to ensure that seeding of "sticky" stromal cells did not foul the electrode and compromise sensor performance. This microsystem with integrated aptasensors was used to monitor TGF-β1 release from activated stellate cells over the course of 20 h. The electrochemical response went down upon infusing anti-TGF-β1 antibodies into the microfluidic devices containing activated stellate cells. To further validate aptasensor responses, stellate cells were stained for markers of activation (e.g., alpha smooth muscle actin) and were also tested for presence of TGF-β1 using enzyme linked immunosorbent assay (ELISA). Given the importance of TGF-β1 as a fibrogenic signal, a microsystem with integrated biosensors for local and continuous detection of TGF-β1 may prove to be an important tool to study fibrosis of the liver and other organs.

  10. Third-order symplectic integration method with inverse time dispersion transform for long-term simulation

    NASA Astrophysics Data System (ADS)

    Gao, Yingjie; Zhang, Jinhai; Yao, Zhenxing

    2016-06-01

    The symplectic integration method is popular in high-accuracy numerical simulations when discretizing temporal derivatives; however, it still suffers from time-dispersion error when the temporal interval is coarse, especially for long-term simulations and large-scale models. We employ the inverse time dispersion transform (ITDT) to the third-order symplectic integration method to reduce the time-dispersion error. First, we adopt the pseudospectral algorithm for the spatial discretization and the third-order symplectic integration method for the temporal discretization. Then, we apply the ITDT to eliminate time-dispersion error from the synthetic data. As a post-processing method, the ITDT can be easily cascaded in traditional numerical simulations. We implement the ITDT in one typical exiting third-order symplectic scheme and compare its performances with the performances of the conventional second-order scheme and the rapid expansion method. Theoretical analyses and numerical experiments show that the ITDT can significantly reduce the time-dispersion error, especially for long travel times. The implementation of the ITDT requires some additional computations on correcting the time-dispersion error, but it allows us to use the maximum temporal interval under stability conditions; thus, its final computational efficiency would be higher than that of the traditional symplectic integration method for long-term simulations. With the aid of the ITDT, we can obtain much more accurate simulation results but with a lower computational cost.

  11. TRANSVERSE MERCATOR MAP PROJECTION OF THE SPHEROID USING TRANSFORMATION OF THE ELLIPTIC INTEGRAL

    NASA Technical Reports Server (NTRS)

    Wallis, D. E.

    1994-01-01

    the (irreducible) Incomplete Elliptic Integral of the 2nd Kind, the value for the tangent of one half the amplitude of the Elliptic Integral of the 2nd Kind is now known. The elliptic integral may now be computed by any desired method, and the result will be the Gauss-Kruger Transverse Mercator Projection. This result is a consequence of the fact that these steps produce a computation of real distance along the image (in the plane) of the principal meridian, and an analytic continuation of the distance at points that don't lie on the principal meridian. The elliptic-integral method used by this program is one of the "transformations of the elliptic integral" (similar to Landen's Transformation), appearing in standard handbooks of mathematical functions. Only elementary transcendental functions are utilized. The program output is the conventional (as used by the mapping agencies) cartesian coordinates, in meters, of the Transverse Mercator projection. The origin is at the intersection of the principal meridian and the equator. This FORTRAN77 program was developed on an IBM PC series computer equipped with an Intel Math Coprocessor. Double precision complex arithmetic and transcendental functions are needed to support a projection accuracy of 1 mm. Because such functions are not usually part of the FORTRAN library, the needed functions have been explicitly programmed and included in the source code. The program was developed in 1989. TRANSVERSE MERCATOR MAP PROJECTION OF THE SPHEROID USING TRANSFORMATIONS OF THE ELLIPTIC INTEGRAL is a copyrighted work with all copyright vested in NASA.

  12. Integrating RFID technique to design mobile handheld inventory management system

    NASA Astrophysics Data System (ADS)

    Huang, Yo-Ping; Yen, Wei; Chen, Shih-Chung

    2008-04-01

    An RFID-based mobile handheld inventory management system is proposed in this paper. Differing from the manual inventory management method, the proposed system works on the personal digital assistant (PDA) with an RFID reader. The system identifies electronic tags on the properties and checks the property information in the back-end database server through a ubiquitous wireless network. The system also provides a set of functions to manage the back-end inventory database and assigns different levels of access privilege according to various user categories. In the back-end database server, to prevent improper or illegal accesses, the server not only stores the inventory database and user privilege information, but also keeps track of the user activities in the server including the login and logout time and location, the records of database accessing, and every modification of the tables. Some experimental results are presented to verify the applicability of the integrated RFID-based mobile handheld inventory management system.

  13. Omics integrating physical techniques: aged Piedmontese meat analysis.

    PubMed

    Lana, Alessandro; Longo, Valentina; Dalmasso, Alessandra; D'Alessandro, Angelo; Bottero, Maria Teresa; Zolla, Lello

    2015-04-01

    Piedmontese meat tenderness becomes higher by extending the ageing period after slaughter up to 44 days. Classical physical analysis only partially explain this evidence, so in order to discover the reason of the potential beneficial effects of prolonged ageing, we performed omic analysis in the Longissimus thoracis muscle by examining main biochemical changes through mass spectrometry-based metabolomics and proteomics. We observed a progressive decline in myofibrillar structural integrity (underpinning meat tenderness) and impaired energy metabolism. Markers of autophagic responses (e.g. serine and glutathione metabolism) and nitrogen metabolism (urea cycle intermediates) accumulated until the end of the assayed period. Key metabolites such as glutamate, a mediator of the appreciated umami taste of the meat, were found to constantly accumulate until day 44. Finally, statistical analyses revealed that glutamate, serine and arginine could serve as good predictors of ultimate meat quality parameters, even though further studies are mandatory.

  14. Determining Plutonium Mass in Spent Fuel with Nondestructive Assay Techniques -- Preliminary Modeling Results Emphasizing Integration among Techniques

    SciTech Connect

    Tobin, S. J.; Fensin, M. L.; Ludewigt, B. A.; Menlove, H. O.; Quiter, B. J.; Sandoval, N. P.; Swinhoe, M. T.; Thompson, S. J.

    2009-08-03

    There are a variety of motivations for quantifying Pu in spent (used) fuel assemblies by means of nondestructive assay (NDA) including the following: strengthen the capabilities of the International Atomic Energy Agencies to safeguards nuclear facilities, quantifying shipper/receiver difference, determining the input accountability value at reprocessing facilities and providing quantitative input to burnup credit determination for repositories. For the purpose of determining the Pu mass in spent fuel assemblies, twelve NDA techniques were identified that provide information about the composition of an assembly. A key point motivating the present research path is the realization that none of these techniques, in isolation, is capable of both (1) quantifying the elemental Pu mass of an assembly and (2) detecting the diversion of a significant number of pins. As such, the focus of this work is determining how to best integrate 2 or 3 techniques into a system that can quantify elemental Pu and to assess how well this system can detect material diversion. Furthermore, it is important economically to down-select among the various techniques before advancing to the experimental phase. In order to achieve this dual goal of integration and down-selection, a Monte Carlo library of PWR assemblies was created and is described in another paper at Global 2009 (Fensin et al.). The research presented here emphasizes integration among techniques. An overview of a five year research plan starting in 2009 is given. Preliminary modeling results for the Monte Carlo assembly library are presented for 3 NDA techniques: Delayed Neutrons, Differential Die-Away, and Nuclear Resonance Fluorescence. As part of the focus on integration, the concept of"Pu isotopic correlation" is discussed and the role of cooling time determination.

  15. A technique to study Meloidogyne arenaria resistance in Agrobacterium rhizogenes-transformed peanut

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A reliable peanut root transformation system would be useful to study the functions of genes involved in root biology and disease resistance. The objective of this study was to establish an effective protocol to produce composite plants mediated by Agrobacterium rhizogenes transformation. More tha...

  16. Robust hermetic packaging techniques for MEMS integrated microsystems.

    SciTech Connect

    Chae, Junseok; Stark, Brian H.; Kuo, Andrew; Oliver, Andrew David; Najafi, Khalil

    2005-03-01

    This work is the result of a Sandia National Laboratories LDRD funded fellowship at the University of Michigan. Although, guidance and suggestions were offered by Sandia, the work contained here is primarily the work of Brian H. Stark, and his advisor, Professor Khalil Najafi. Junseok Chae, Andrew Kuo, and their coworkers at the University of Michigan helped to record some of the data. The following is an abstract of their work. We have developed a vacuum packaging technology using a thick nickel film to seal MEMS structures at the wafer level. The package is fabricated in a three-mask process by electroplating a 40 micro-meter thick nickel film over an 8 micro-meter sacrificial photoresist that is removed prior to package sealing. Implementation of electrical feedthroughs in this process requires no planarization. The large release channel enables an 800x800 micro-meter package to be released in less than three hours. Several mechanisms, based upon localized melting and lead/tin solder bumping, for sealing the release channel have been investigated. We have also developed Pirani gauges, integrated with this package, which can be used to establish the hermeticity of the different sealing technologies. They have measured a sealing pressure of approximately 1.5 Torr. Our work differs from previous Pirani gauges in that we utilize a novel doubly anchored structure that stiffens the structural membrane while not substantially degrading performance in order to measure fine leak rates.

  17. Review of high-throughput techniques for detecting solid phase Transformation from material libraries produced by combinatorial methods

    NASA Technical Reports Server (NTRS)

    Lee, Jonathan A.

    2005-01-01

    High-throughput measurement techniques are reviewed for solid phase transformation from materials produced by combinatorial methods, which are highly efficient concepts to fabricate large variety of material libraries with different compositional gradients on a single wafer. Combinatorial methods hold high potential for reducing the time and costs associated with the development of new materials, as compared to time-consuming and labor-intensive conventional methods that test large batches of material, one- composition at a time. These high-throughput techniques can be automated to rapidly capture and analyze data, using the entire material library on a single wafer, thereby accelerating the pace of materials discovery and knowledge generation for solid phase transformations. The review covers experimental techniques that are applicable to inorganic materials such as shape memory alloys, graded materials, metal hydrides, ferric materials, semiconductors and industrial alloys.

  18. Optical implementation of improved resolution with intermediate-view reconstruction technique based on integral imaging

    NASA Astrophysics Data System (ADS)

    Lee, Keong-Jin; Lee, Sang-Tae; Oh, Yong-Seok; Hong, Suk-Pyo; Kim, Chang-Keun; Kim, Eun-Soo

    2008-02-01

    To overcome the viewing resolution limit defined by the Nyquist sampling theorem for a given lenslet pitch, a Moving Array-Lens Technique (MALT) was developed in 3-D integral imaging technique. Even though the MALT is an effective method for resolution improvement of Integral Imaging, this cannot be applied to a real-time 3-D integral imaging display system because of its mechanical movement. In this paper, we propose an integral imaging display using a computational pick-up method based on Intermediate-View Reconstruction Technique instead of optical moving pickup. We show that the proposed system can provide optically resolution-improved 3-D images of integral imaging by use of EIs generated by the IVRT through the optical experiments.

  19. A technique for integrating engine cycle and aircraft configuration optimization

    NASA Technical Reports Server (NTRS)

    Geiselhart, Karl A.

    1994-01-01

    A method for conceptual aircraft design that incorporates the optimization of major engine design variables for a variety of cycle types was developed. The methodology should improve the lengthy screening process currently involved in selecting an appropriate engine cycle for a given application or mission. The new capability will allow environmental concerns such as airport noise and emissions to be addressed early in the design process. The ability to rapidly perform optimization and parametric variations using both engine cycle and aircraft design variables, and to see the impact on the aircraft, should provide insight and guidance for more detailed studies. A brief description of the aircraft performance and mission analysis program and the engine cycle analysis program that were used is given. A new method of predicting propulsion system weight and dimensions using thermodynamic cycle data, preliminary design, and semi-empirical techniques is introduced. Propulsion system performance and weights data generated by the program are compared with industry data and data generated using well established codes. The ability of the optimization techniques to locate an optimum is demonstrated and some of the problems that had to be solved to accomplish this are illustrated. Results from the application of the program to the analysis of three supersonic transport concepts installed with mixed flow turbofans are presented. The results from the application to a Mach 2.4, 5000 n.mi. transport indicate that the optimum bypass ratio is near 0.45 with less than 1 percent variation in minimum gross weight for bypass ratios ranging from 0.3 to 0.6. In the final application of the program, a low sonic boom fix a takeoff gross weight concept that would fly at Mach 2.0 overwater and at Mach 1.6 overland is compared with a baseline concept of the same takeoff gross weight that would fly Mach 2.4 overwater and subsonically overland. The results indicate that for the design mission

  20. Application of Reflectance Transformation Imaging Technique to Improve Automated Edge Detection in a Fossilized Oyster Reef

    NASA Astrophysics Data System (ADS)

    Djuricic, Ana; Puttonen, Eetu; Harzhauser, Mathias; Dorninger, Peter; Székely, Balázs; Mandic, Oleg; Nothegger, Clemens; Molnár, Gábor; Pfeifer, Norbert

    2016-04-01

    The world's largest fossilized oyster reef is located in Stetten, Lower Austria excavated during field campaigns of the Natural History Museum Vienna between 2005 and 2008. It is studied in paleontology to learn about change in climate from past events. In order to support this study, a laser scanning and photogrammetric campaign was organized in 2014 for 3D documentation of the large and complex site. The 3D point clouds and high resolution images from this field campaign are visualized by photogrammetric methods in form of digital surface models (DSM, 1 mm resolution) and orthophoto (0.5 mm resolution) to help paleontological interpretation of data. Due to size of the reef, automated analysis techniques are needed to interpret all digital data obtained from the field. One of the key components in successful automation is detection of oyster shell edges. We have tested Reflectance Transformation Imaging (RTI) to visualize the reef data sets for end-users through a cultural heritage viewing interface (RTIViewer). The implementation includes a Lambert shading method to visualize DSMs derived from terrestrial laser scanning using scientific software OPALS. In contrast to shaded RTI no devices consisting of a hardware system with LED lights, or a body to rotate the light source around the object are needed. The gray value for a given shaded pixel is related to the angle between light source and the normal at that position. Brighter values correspond to the slope surfaces facing the light source. Increasing of zenith angle results in internal shading all over the reef surface. In total, oyster reef surface contains 81 DSMs with 3 m x 2 m each. Their surface was illuminated by moving the virtual sun every 30 degrees (12 azimuth angles from 20-350) and every 20 degrees (4 zenith angles from 20-80). This technique provides paleontologists an interactive approach to virtually inspect the oyster reef, and to interpret the shell surface by changing the light source direction

  1. Identification of auxotrophic mutants of the yeast Kluyveromyces marxianus by non-homologous end joining-mediated integrative transformation with genes from Saccharomyces cerevisiae.

    PubMed

    Yarimizu, Tohru; Nonklang, Sanom; Nakamura, Junpei; Tokuda, Shuya; Nakagawa, Takaaki; Lorreungsil, Sasithorn; Sutthikhumpha, Surasit; Pukahuta, Charida; Kitagawa, Takao; Nakamura, Mikiko; Cha-Aim, Kamonchai; Limtong, Savitree; Hoshida, Hisashi; Akada, Rinji

    2013-12-01

    The isolation and application of auxotrophic mutants for gene manipulations, such as genetic transformation, mating selection and tetrad analysis, form the basis of yeast genetics. For the development of these genetic methods in the thermotolerant fermentative yeast Kluyveromyces marxianus, we isolated a series of auxotrophic mutants with defects in amino acid or nucleic acid metabolism. To identify the mutated genes, linear DNA fragments of nutrient biosynthetic pathway genes were amplified from Saccharomyces cerevisiae chromosomal DNA and used to directly transform the K. marxianus auxotrophic mutants by random integration into chromosomes through non-homologous end joining (NHEJ). The appearance of transformant colonies indicated that the specific S. cerevisiae gene complemented the K. marxianus mutant. Using this interspecific complementation approach with linear PCR-amplified DNA, we identified auxotrophic mutations of ADE2, ADE5,7, ADE6, HIS2, HIS3, HIS4, HIS5, HIS6, HIS7, LYS1, LYS2, LYS4, LYS9, LEU1, LEU2, MET2, MET6, MET17, TRP3, TRP4 and TRP5 without the labour-intensive requirement of plasmid construction. Mating, sporulation and tetrad analysis techniques for K. marxianus were also established. With the identified auxotrophic mutant strains and S. cerevisiae genes as selective markers, NHEJ-mediated integrative transformation with PCR-amplified DNA is an attractive system for facilitating genetic analyses in the yeast K. marxianus.

  2. A new method to calculate the beam charge for an integrating current transformer.

    PubMed

    Wu, Yuchi; Han, Dan; Zhu, Bin; Dong, Kegong; Tan, Fang; Gu, Yuqiu

    2012-09-01

    The integrating current transformer (ICT) is a magnetic sensor widely used to precisely measure the charge of an ultra-short-pulse charged particle beam generated by traditional accelerators and new laser-plasma particle accelerators. In this paper, we present a new method to calculate the beam charge in an ICT based on circuit analysis. The output transfer function shows an invariable signal profile for an ultra-short electron bunch, so the function can be used to evaluate the signal quality and calculate the beam charge through signal fitting. We obtain a set of parameters in the output function from a standard signal generated by an ultra-short electron bunch (about 1 ps in duration) at a radio frequency linear electron accelerator at Tsinghua University. These parameters can be used to obtain the beam charge by signal fitting with excellent accuracy. PMID:23020370

  3. Use of the Distance Transform for Integration of Local Measurements: Principle and Application in Chemical Engineering.

    PubMed

    Sorbier, Loïc; Bazer-Bachi, Frédéric; Blouët, Yannick; Moreaud, Maxime; Moizan-Basle, Virginie

    2016-04-01

    We propose an original methodology to integrate local measurement for nontrivial object shape. The method employs the distance transform of the object and least-square fitting of numerically computed weighting functions extracted from it. The method is exemplified in the field of chemical engineering by calculating the global metal concentration in catalyst grains from uneven metal distribution profiles. Applying the methodology on synthetic profiles with the help of a very simple deposition model allows us to evaluate the accuracy of the method. For high symmetry objects such as an infinite cylinder, relative errors on global concentration are lower than 1% for well-resolved profiles. For a less symmetrical object, a tetralobe, the best estimator gives a relative error below 5% at the cost of increased measurement time. Applicability on a real case is demonstrated on an aged hydrodemetallation catalyst. Sampling of catalyst grains at the inlet and outlet of the reactor allowed conclusions concerning different reactivity for the trapped metals.

  4. Reconstructing Folding Energy Landscape Profiles from Nonequilibrium Pulling Curves with an Inverse Weierstrass Integral Transform

    NASA Astrophysics Data System (ADS)

    Engel, Megan C.; Ritchie, Dustin B.; Foster, Daniel A. N.; Beach, Kevin S. D.; Woodside, Michael T.

    2014-12-01

    The energy landscapes that drive structure formation in biopolymers are difficult to measure. Here we validate experimentally a novel method to reconstruct landscape profiles from single-molecule pulling curves using an inverse Weierstrass transform (IWT) of the Jarzysnki free-energy integral. The method was applied to unfolding measurements of a DNA hairpin, replicating the results found by the more-established weighted histogram (WHAM) and inverse Boltzmann methods. Applying both WHAM and IWT methods to reconstruct the folding landscape for a RNA pseudoknot having a stiff energy barrier, we found that landscape features with sharper curvature than the force probe stiffness could not be recovered with the IWT method. The IWT method is thus best for analyzing data from stiff force probes such as atomic force microscopes.

  5. Transformation and availability of nutrients and heavy metals during integrated composting-vermicomposting of sewage sludges.

    PubMed

    Hait, Subrata; Tare, Vinod

    2012-05-01

    Transformation and availability of nutrients and some heavy metals were assessed during the integrated composting-vermicomposting of both primary sewage sludge (PSS) and waste activated sewage sludge (WAS) using matured vermicompost as indigenous bulking material and employing Eisenia fetida as earthworm species. Vermicomposting resulted in significant increase in total N (TN) (PSS: 41.7-64.6%, F=11.6, P<0.05; WAS: 36.4-58.6%, F=6.4, P<0.05), water soluble N (WSN) (PSS: 37.1-50.5%, F=30.1, P<0.05; WAS: 40.1-53.0%, F=27.6, P<0.05), total P (TP) (PSS: 39.9-69.8%, F=27.1, P<0.05; WAS: 32.2-56.6%, F=21.4, P<0.05) and water soluble P (WSP) (PSS: 25.2-34.3%, F=163.9, P<0.05; WAS: 24.1-34.2%, F=144.3, P<0.05) as compared to the initial compost material depending on different experimental conditions. The study demonstrated that the vermicomposting significantly improved the availability of nutrients in sewage sludges. In addition, vermicomposting considerably reduced the availability of heavy metals except Fe and Mn, presumably by forming organic-bound complexes in spite of several fold increase in their total content. The environmental conditions (i.e., temperature and relative humidity), in general, showed significant effect on the transformation and availability of nutrients and heavy metals. There was no effect of earthworm density on the transformation and availability of heavy metals and nutrients except N and P, possibly due to prior exposure during acclimation period in sewage sludge. PMID:22277776

  6. The Effect of Cooperative Integrated Reading and Composition Technique on Students' Reading Descriptive Text Achievement

    ERIC Educational Resources Information Center

    Zainuddin

    2015-01-01

    This study was aimed at finding out the effectiveness of applying Cooperative Integrated Reading and Composition (CIRC) Technique on Students' Reading Descriptive Text Achievement. In other words, the objective of this study was to find out if there was a significant effect of applying Cooperative Integrated Reading and Composition (CIRC)…

  7. Three New (2+1)-dimensional Integrable Systems and Some Related Darboux Transformations

    NASA Astrophysics Data System (ADS)

    Guo, Xiu-Rong

    2016-06-01

    We introduce two operator commutators by using different-degree loop algebras of the Lie algebra A1, then under the framework of zero curvature equations we generate two (2+1)-dimensional integrable hierarchies, including the (2+1)-dimensional shallow water wave (SWW) hierarchy and the (2+1)-dimensional Kaup-Newell (KN) hierarchy. Through reduction of the (2+1)-dimensional hierarchies, we get a (2+1)-dimensional SWW equation and a (2+1)-dimensional KN equation. Furthermore, we obtain two Darboux transformations of the (2+1)-dimensional SWW equation. Similarly, the Darboux transformations of the (2+1)-dimensional KN equation could be deduced. Finally, with the help of the spatial spectral matrix of SWW hierarchy, we generate a (2+1) heat equation and a (2+1) nonlinear generalized SWW system containing inverse operators with respect to the variables x and y by using a reduction spectral problem from the self-dual Yang-Mills equations. Supported by the National Natural Science Foundation of China under Grant No. 11371361, the Shandong Provincial Natural Science Foundation of China under Grant Nos. ZR2012AQ011, ZR2013AL016, ZR2015EM042, National Social Science Foundation of China under Grant No. 13BJY026, the Development of Science and Technology Project under Grant No. 2015NS1048 and A Project of Shandong Province Higher Educational Science and Technology Program under Grant No. J14LI58

  8. The use of artificial intelligence techniques to improve the multiple payload integration process

    NASA Technical Reports Server (NTRS)

    Cutts, Dannie E.; Widgren, Brian K.

    1992-01-01

    A maximum return of science and products with a minimum expenditure of time and resources is a major goal of mission payload integration. A critical component then, in successful mission payload integration is the acquisition and analysis of experiment requirements from the principal investigator and payload element developer teams. One effort to use artificial intelligence techniques to improve the acquisition and analysis of experiment requirements within the payload integration process is described.

  9. ORGANIC ACID DERIVATIZATION TECHNIQUES APPLIED TO PETROLEUM HYDROCARBON TRANSFORMATIONS IN SUBSURFACE ENVIRONMENTS

    EPA Science Inventory

    Evidence for the natural microbial remediation of subsurface fuel contamination situations should include identification and analysis of transformation or degradation products. In this way. u mass balance between fuel constituents and end products may be approached to monitor cle...

  10. The Kinetic Drawing System: A Review and Integration of the Kinetic Family and School Drawing Techniques.

    ERIC Educational Resources Information Center

    Knoff, Howard M.; Prout, H. Thompson

    1985-01-01

    Presents the Kinetic Drawing System as a logical integration of the Kinetic Family Drawing and Kinetic School Drawing techniques. Reviews the literature of these two projective techniques and provides a rationale and process toward their combination into a single approach. (LLL)

  11. Evaluation of EBV transformation of human memory B-cells isolated by FACS and MACS techniques.

    PubMed

    Sadreddini, Sanam; Jadidi-Niaragh, Farhad; Younesi, Vahid; Pourlak, Tala; Afkham, Amir; Shokri, Fazel; Yousefi, Mehdi

    2016-07-01

    Several studies have been performed to develop effective neutralizing monoclonal antibodies. The Epstein-Barr virus (EBV) can efficiently immortalize B-cells to establish lymphoblastoid cell lines (LCL) and so it has been used extensively for transformation of B-cells to produce and secrete immunoglobulin. The present study addressed the effect of TLR7/8 agonist (R848), feeder cells layer and fluorescence-activated cell sorting (FACS) and magnetic-activated cell sorting (MACS) cell separation methods on the transformation efficiency of antibody-producing memory B-cells. For these studies, the antigen used for analyses of antibody formation was the tetanus neurotoxin (TeNT) derived from Clostridium tetani. The results here showed that employing an HFFF.PI6 feeder cell layer, R848 agonist and FACS-mediated purification of memory B-cells led to increased transformation efficiency. Altogether, the effects of the R848 and the feeder cells provided an efficient method for EBV transformation of human B-cells. Moreover, there was an advantage in using FACS sorting of B-cells over the MACS method in the context of EBV transformation and immortalization of precursors of antigen-specific B-cells.

  12. Evaluation of EBV transformation of human memory B-cells isolated by FACS and MACS techniques.

    PubMed

    Sadreddini, Sanam; Jadidi-Niaragh, Farhad; Younesi, Vahid; Pourlak, Tala; Afkham, Amir; Shokri, Fazel; Yousefi, Mehdi

    2016-07-01

    Several studies have been performed to develop effective neutralizing monoclonal antibodies. The Epstein-Barr virus (EBV) can efficiently immortalize B-cells to establish lymphoblastoid cell lines (LCL) and so it has been used extensively for transformation of B-cells to produce and secrete immunoglobulin. The present study addressed the effect of TLR7/8 agonist (R848), feeder cells layer and fluorescence-activated cell sorting (FACS) and magnetic-activated cell sorting (MACS) cell separation methods on the transformation efficiency of antibody-producing memory B-cells. For these studies, the antigen used for analyses of antibody formation was the tetanus neurotoxin (TeNT) derived from Clostridium tetani. The results here showed that employing an HFFF.PI6 feeder cell layer, R848 agonist and FACS-mediated purification of memory B-cells led to increased transformation efficiency. Altogether, the effects of the R848 and the feeder cells provided an efficient method for EBV transformation of human B-cells. Moreover, there was an advantage in using FACS sorting of B-cells over the MACS method in the context of EBV transformation and immortalization of precursors of antigen-specific B-cells. PMID:27043044

  13. On-line preferential solvation studies of polymers by coupled chromatographic-Fourier transform infrared spectroscopic flow-cell technique.

    PubMed

    Malanin, M; Eichhorn, K-J; Lederer, A; Treppe, P; Adam, G; Fischer, D; Voigt, D

    2009-12-18

    Qualitative and quantitative comparison between liquid chromatography (LC) and LC coupled with Fourier transform infrared spectroscopy (LC-FTIR) to evaluate preferential solvation phenomenon of polymers in a mixed solvent has been performed. These studies show that LC-FTIR technique leads to detailed structural information without the requirement for determination of additional parameters for quantitative analysis except calibration. Appropriate experimental conditions for preferential solvation study have been established by variation of polymer concentration, molar mass and eluent content.

  14. Pattern recognition using versatile hybrid joint transform correlators: some techniques for improving the performance

    NASA Astrophysics Data System (ADS)

    Pati, G. S.; Singh, Kehar

    1999-04-01

    This paper reports the outcome of research studies carried out by us in the area of Optical Pattern Recognition. A hybrid JTC architecture has been used to evaluate correlation performance of four different types of JTCs in a non-cooperative situation. A non-zero order JTC has been proposed based on the principle of differential processing of joint power spectrum and its sensitivity to illumination variation has been investigated. A hybrid wavelet transform based JTC has been proposed and demonstrated to achieve high image discrimination. Hartley transform has been introduced in joint-transform correlation. Chirp modulation in HJTC has been demonstrated to extract information on object correlation and absolute object position from correlation output. A discrimination sensitive rotation-invariant JTC has been proposed based on gradient preprocessing and circular harmonic decomposition.

  15. A non-intrusive and continuous-in-space technique to investigate the wave transformation and breaking over a breakwater

    NASA Astrophysics Data System (ADS)

    Ferrari, Simone; Grazia Badas, Maria; Querzoli, Giorgio

    2016-03-01

    To design longshore breakwaters, the evaluation of the wave motion transformations over the structures and of the energy they are able to absorb, dissipate and reflect is necessary. To characterize features and transformations of monochromatic wave trains above a breakwater, both submerged and emerged, we have designed and developed a non-intrusive and continuous-in-space technique, based on Image Analysis, and carried out an experimental campaign, in a laboratory flume equipped with a wave-maker, in order to test it. The investigation area was lighted with a light sheet and images were recorded by a video-camera. The working fluid was seeded with non buoyant particles to make it bright and clearly distinct from dark background and breakwater. The technique, that is based on a robust algorithm to identify the free surface, has showed to properly work also in prohibitive situations for traditional resistive probes (e.g., very shallow waters and/or breaking waves) and to be able to measure the free surface all over the investigation field in a non-intrusive way. Two kind of analysis were mainly performed, a statistical and a spectral one. The peculiarities of the measurement technique allowed to describe the whole wave transformation and to supply useful information for design purposes.

  16. Ultra-fast dynamic compression technique to study kinetics of phase transformations in Bismuth

    SciTech Connect

    Smith, R F; Kane, J O; Eggert, J H; Saculla, M D; Jankowski, A F; Bastea, M; Hicks, D G; Collins, G W

    2007-12-28

    Pre-heated Bi was ramp compressed within 30 ns to a peak stress of {approx}11 GPa to explore structural phase transformation kinetics under dynamic loading conditions. Under these ultra-fast compression time-scales the equilibrium Bi I-II phase boundary is overpressurized by {Delta}P {approx} 0.8 GPa. {Delta}P is observed to increase logarithmically with strain rate, {var_epsilon}, above 10{sup 6} s{sup -1}. Estimates from a kinetics model predict that the Bi I phase is fully transformed within 3 ns.

  17. Transformation of Resources to Reserves: Next Generation Heavy-Oil Recovery Techniques

    SciTech Connect

    Stanford University; Department of Energy Resources Engineering Green Earth Sciences

    2007-09-30

    This final report and technical progress report describes work performed from October 1, 2004 through September 30, 2007 for the project 'Transformation of Resources to Reserves: Next Generation Heavy Oil Recovery Techniques', DE-FC26-04NT15526. Critical year 3 activities of this project were not undertaken because of reduced funding to the DOE Oil Program despite timely submission of a continuation package and progress on year 1 and 2 subtasks. A small amount of carried-over funds were used during June-August 2007 to complete some work in the area of foamed-gas mobility control. Completion of Year 3 activities and tasks would have led to a more thorough completion of the project and attainment of project goals. This progress report serves as a summary of activities and accomplishments for years 1 and 2. Experiments, theory development, and numerical modeling were employed to elucidate heavy-oil production mechanisms that provide the technical foundations for producing efficiently the abundant, discovered heavy-oil resources of the U.S. that are not accessible with current technology and recovery techniques. Work fell into two task areas: cold production of heavy oils and thermal recovery. Despite the emerging critical importance of the waterflooding of viscous oil in cold environments, work in this area was never sanctioned under this project. It is envisioned that heavy oil production is impacted by development of an understanding of the reservoir and reservoir fluid conditions leading to so-called foamy oil behavior, i.e, heavy-oil solution gas drive. This understanding should allow primary, cold production of heavy and viscous oils to be optimized. Accordingly, we evaluated the oil-phase chemistry of crude oil samples from Venezuela that give effective production by the heavy-oil solution gas drive mechanism. Laboratory-scale experiments show that recovery correlates with asphaltene contents as well as the so-called acid number (AN) and base number (BN) of the

  18. Exogenous Gene Integration for Microalgal Cell Transformation Using a Nanowire-Incorporated Microdevice.

    PubMed

    Bae, Sunwoong; Park, Seunghye; Kim, Jung; Choi, Jong Seob; Kim, Kyung Hoon; Kwon, Donguk; Jin, EonSeon; Park, Inkyu; Kim, Do Hyun; Seo, Tae Seok

    2015-12-16

    Superior green algal cells showing high lipid production and rapid growth rate are considered as an alternative for the next generation green energy resources. To achieve the biomass based energy generation, transformed microalgae with superlative properties should be developed through genetic engineering. Contrary to the normal cells, microalgae have rigid cell walls, so that target gene delivery into cells is challengeable. In this study, we report a ZnO nanowire-incorporated microdevice for a high throughput microalgal transformation. The proposed microdevice was equipped with not only a ZnO nanowire in the microchannel for gene delivery into cells but also a pneumatic polydimethylsiloxane (PDMS) microvalve to modulate the cellular attachment and detachment from the nanowire. As a model, hygromycin B resistance gene cassette (Hyg3) was functionalized on the hydrothermally grown ZnO nanowires through a disulfide bond and released into green algal cells, Chlamydomonas reinhardtii, by reductive cleavage. During Hyg3 gene delivery, a monolithic PDMS membrane was bent down, so that algal cells were pushed down toward ZnO nanowires. The supply of vacuum in the pneumatic line made the PDMS membrane bend up, enabling the gene delivered algal cells to be recovered from the outlet of the microchannel. We successfully confirmed Hyg3 gene integrated in microalgae by amplifying the inserted gene through polymerase chain reaction (PCR) and DNA sequencing. The efficiency of the gene delivery to algal cells using the ZnO nanowire-incorporated microdevice was 6.52 × 10(4)- and 9.66 × 10(4)-fold higher than that of a traditional glass bead beating and electroporation. PMID:26584003

  19. The conceptual basis of mathematics in cardiology III: linear systems theory and integral transforms.

    PubMed

    Bates, Jason H T; Sobel, Burton E

    2003-05-01

    This is the third in a series of four articles developed for the readers of Coronary Artery Disease. Without language ideas cannot be articulated. What may not be so immediately obvious is that they cannot be formulated either. One of the essential languages of cardiology is mathematics. Unfortunately, medical education does not emphasize, and in fact, often neglects empowering physicians to think mathematically. Reference to statistics, conditional probability, multicompartmental modeling, algebra, calculus and transforms is common but often without provision of genuine conceptual understanding. At the University of Vermont College of Medicine, Professor Bates developed a course designed to address these deficiencies. The course covered mathematical principles pertinent to clinical cardiovascular and pulmonary medicine and research. It focused on fundamental concepts to facilitate formulation and grasp of ideas.This series of four articles was developed to make the material available for a wider audience. The articles will be published sequentially in Coronary Artery Disease. Beginning with fundamental axioms and basic algebraic manipulations they address algebra, function and graph theory, real and complex numbers, calculus and differential equations, mathematical modeling, linear system theory and integral transforms and statistical theory. The principles and concepts they address provide the foundation needed for in-depth study of any of these topics. Perhaps of even more importance, they should empower cardiologists and cardiovascular researchers to utilize the language of mathematics in assessing the phenomena of immediate pertinence to diagnosis, pathophysiology and therapeutics. The presentations are interposed with queries (by Coronary Artery Disease abbreviated as CAD) simulating the nature of interactions that occurred during the course itself. Each article concludes with one or more examples illustrating application of the concepts covered to

  20. Electrochemical technique and copper-promoted transformations: selective hydroxylation and amination of arylboronic acids.

    PubMed

    Qi, Hong-Lin; Chen, Dong-Song; Ye, Jian-Shan; Huang, Jing-Mei

    2013-08-01

    An efficient and selective electrosynthesis of phenols and anilines from arylboronic acids in aqueous ammonia is achieved in an undivided cell. By simply changing the concentration of aqueous ammonia and the anode potential, good yields of phenols and anilines can be obtained chemoselectively with high reaction rates. We propose that anodic oxidation could have played an important role in these transformations. PMID:23808633

  1. Applications of integrated human error identification techniques on the chemical cylinder change task.

    PubMed

    Cheng, Ching-Min; Hwang, Sheue-Ling

    2015-03-01

    This paper outlines the human error identification (HEI) techniques that currently exist to assess latent human errors. Many formal error identification techniques have existed for years, but few have been validated to cover latent human error analysis in different domains. This study considers many possible error modes and influential factors, including external error modes, internal error modes, psychological error mechanisms, and performance shaping factors, and integrates several execution procedures and frameworks of HEI techniques. The case study in this research was the operational process of changing chemical cylinders in a factory. In addition, the integrated HEI method was used to assess the operational processes and the system's reliability. It was concluded that the integrated method is a valuable aid to develop much safer operational processes and can be used to predict human error rates on critical tasks in the plant.

  2. Leading Education Reform Initiatives: How SWIFT (Schoolwide Integrated Framework for Transformation) Coordinates and Enhances Impact. Issue Brief #2

    ERIC Educational Resources Information Center

    Kingston, Mary; Richards, Curtis; Blank, Rolf; Stonemeier, Jennifer; Trader, Barbara; East, Bill

    2014-01-01

    In this Issue Brief we discuss the impact that the Schoolwide Integrated Framework for Transformation (SWIFT) has on improving the outcomes of several current federal, state, district, and school education reform initiatives. Federal initiatives include Race to the Top, School Improvement Grants, and Campaign for Grade-Level Reading; Common Core…

  3. PLANE-INTEGRATED OPEN-PATH FOURIER TRANSFORM INFRARED SPECTROMETRY METHODOLOGY FOR ANAEROBIC SWINE LAGOON EMISSION MEASUREMENTS

    EPA Science Inventory

    Emissions of ammonia and methane from an anaerobic lagoon at a swine animal feeding operation were evaluated five times over a period of two years. The plane-integrated (PI) open-path Fourier transform infrared spectrometry (OP-FTIR) methodology was used to transect the plume at ...

  4. Transformation of haploid Datura innoxia protoplasts and analysis of the plasmid integration pattern in regenerated transgenic plants.

    PubMed

    Schmidt-Rogge, T; Meixner, M; Srivastava, V; Guha-Mukherjee, S; Schieder, O

    1993-05-01

    We developed a highly efficient transformation protocol for the PEG-mediated direct transfer of plasmid DNA into protoplasts of haploid Datura innoxia. Vectors harbouring a neomycin phosphotransferase II gene or a hygromycin B phosphotransferase gene under the control of different promoters were used in the transformation experiments. Various amounts of plasmid DNA were applied without any carrier DNA to show the direct influence of the plasmid DNA concentration on the transformation efficiency. Approximately 95% of the selected calli were regenerated to plants; 20% of them remained haploid. Total DNA of different transgenic plants was analysed with regard to the integration pattern of the plasmid DNA. Plants carrying only one or two copies of the vector DNA were observed as well as individuals with multi-copy integration (up to ten or more copies).

  5. An Examination of Sampling Characteristics of Some Analytic Factor Transformation Techniques.

    ERIC Educational Resources Information Center

    Skakun, Ernest N.; Hakstian, A. Ralph

    Two population raw data matrices were constructed by computer simulation techniques. Each consisted of 10,000 subjects and 12 variables, and each was constructed according to an underlying factorial model consisting of four major common factors, eight minor common factors, and 12 unique factors. The computer simulation techniques were employed to…

  6. Morphological and lithological transformation records of the Lake Czechowskie basin on the basis of paleogeography and GIS techniques analysis

    NASA Astrophysics Data System (ADS)

    Kramkowski, M. A.; Błaszkiewicz, M.; Tyszkowski, S.; Kordowski, J.

    2014-12-01

    The analyses of the annually laminated lacustrine sediments are particularly important in the studies of global climate change. They provide information about the ecosystem response to environmental and climate changes. The condition for the laminated sedimentation with the annual resolution is a calm sedimentation environment where there is no mixing and thus there are anaerobic conditions in the benthic zone. Below a certain depth there is no wave induced mixing and temperature is constant, which causes water stagnation. In shallower areas such conditions are favoured by the morphology of the lake basin and the long presence of ice cover (bradymictic). The combination of these environmental features predispose to the deposition of laminated sediments. Lake Czechowskie is located within the limit of the Scandinavian Ice Sheet during the Last Glaciation in the Central European Lowland (northern Poland - 53°52"N 18°14"E) in a deep kettle-hole type. Taking into account the thickness of the lacustrine sediments, the maximum depth of the basin exceeds 70 m. Detailed surveying as well as geological drilling using the GIS techniques made it possible to reconstruct the morphology of the basin of Lake Czechowskie and its adjacent areas before the biogenic sedimentation started in Allerød. At that time water level was 2 m higher than in the modern times. Following climate changes initiated the natural processes of the lake basin transformation. The analysis of the morphology of the lake basin is the basis for modelling the sedimentation conditions considering, inter alia, the wind direction and wind velocity, fluctuations of the water levels and the degree of filling the basin with the deposits in different periods of the Late Glacial and Holocene. It allows specifying the variability and sedimentation rate within the basin. The analysis shows the spatial variation of the erosion and accumulation zones, and enables to determine the zones of calm sedimentation revealing

  7. Transforming Healthcare Delivery: Integrating Dynamic Simulation Modelling and Big Data in Health Economics and Outcomes Research.

    PubMed

    Marshall, Deborah A; Burgos-Liz, Lina; Pasupathy, Kalyan S; Padula, William V; IJzerman, Maarten J; Wong, Peter K; Higashi, Mitchell K; Engbers, Jordan; Wiebe, Samuel; Crown, William; Osgood, Nathaniel D

    2016-02-01

    In the era of the Information Age and personalized medicine, healthcare delivery systems need to be efficient and patient-centred. The health system must be responsive to individual patient choices and preferences about their care, while considering the system consequences. While dynamic simulation modelling (DSM) and big data share characteristics, they present distinct and complementary value in healthcare. Big data and DSM are synergistic-big data offer support to enhance the application of dynamic models, but DSM also can greatly enhance the value conferred by big data. Big data can inform patient-centred care with its high velocity, volume, and variety (the three Vs) over traditional data analytics; however, big data are not sufficient to extract meaningful insights to inform approaches to improve healthcare delivery. DSM can serve as a natural bridge between the wealth of evidence offered by big data and informed decision making as a means of faster, deeper, more consistent learning from that evidence. We discuss the synergies between big data and DSM, practical considerations and challenges, and how integrating big data and DSM can be useful to decision makers to address complex, systemic health economics and outcomes questions and to transform healthcare delivery.

  8. Solving Virasoro constraints on integrable hierarchies via the Kontsevich-Miwa transform

    NASA Astrophysics Data System (ADS)

    Semikhatov, A. M.

    1992-11-01

    We solve Virasoro constraints on the KP hierarchy in terms of minimal conformal models. The constraints we start with are implemented by the Virasoro generators depending on a background charge Q. Then the solutions to the constraints are given by the theory which has the same field content as the David-Distler-Kawai theory: it consists of a minimal matter scalar with background charge Q, dressed with an extra "Liouville" scalar. In particular, the Virasoro-constrained τ-function is related to the correlator of a product of (dressed) "21" operators. The construction is based on a generalization of the Kontsevich parametrization of the KP times achieved by introducing into it Miwa parameters which depend on the value of Q. Under the thus defined Kontsevich-Miwa transformation, the Virasoro constraints are proven to be equivalent to a master equation depending on the parameter Q. The master equation is further identified with the decoupling equation corresponding to a null vector at level 2. We conjecture that higher-level decoupling equations are similarly related to constraints on the KP τ-function. We also consider the master equation for the N-reduced KP hierarchies. Several comments are made on a possible relation between the generalized master equation and scaled Kontsevich-type matrix integrals, and on the form the equation takes in higher genera.

  9. Simultaneous and integrated neutron-based techniques for material analysis of a metallic ancient flute

    NASA Astrophysics Data System (ADS)

    Festa, G.; Pietropaolo, A.; Grazzi, F.; Sutton, L. F.; Scherillo, A.; Bognetti, L.; Bini, A.; Barzagli, E.; Schooneveld, E.; Andreani, C.

    2013-09-01

    A metallic 19th century flute was studied by means of integrated and simultaneous neutron-based techniques: neutron diffraction, neutron radiative capture analysis and neutron radiography. This experiment follows benchmark measurements devoted to assessing the effectiveness of a multitask beamline concept for neutron-based investigation on materials. The aim of this study is to show the potential application of the approach using multiple and integrated neutron-based techniques for musical instruments. Such samples, in the broad scenario of cultural heritage, represent an exciting research field. They may represent an interesting link between different disciplines such as nuclear physics, metallurgy and acoustics.

  10. Integrated velocity field from ground and satellite geodetic techniques: application to Arenal volcano

    NASA Astrophysics Data System (ADS)

    Muller, Cyril; del Potro, Rodrigo; Biggs, Juliet; Gottsmann, Joachim; Ebmeier, Susanna K.; Guillaume, Sébastien; Cattin, Paul-Henri; Van der Laat, Rodolfo

    2015-02-01

    Measurements of ground deformation can be used to identify and interpret geophysical processes occurring at volcanoes. Most studies rely on a single geodetic technique, or fit a geophysical model to the results of multiple geodetic techniques. Here we present a methodology that combines GPS, Total Station measurements and InSAR into a single reference frame to produce an integrated 3-D geodetic velocity surface without any prior geophysical assumptions. The methodology consists of five steps: design of the network, acquisition and processing of the data, spatial integration of the measurements, time series computation and finally the integration of spatial and temporal measurements. The most significant improvements of this method are (1) the reduction of the required field time, (2) the unambiguous detection of outliers, (3) an increased measurement accuracy and (4) the construction of a 3-D geodetic velocity field. We apply this methodology to ongoing motion on Arenal's western flank. Integration of multiple measurement techniques at Arenal volcano revealed a deformation field that is more complex than that described by individual geodetic techniques, yet remains consistent with previous studies. This approach can be applied to volcano monitoring worldwide and has the potential to be extended to incorporate other geodetic techniques and to study transient deformation.

  11. Three-dimensional electro-floating display system based on integral imaging technique

    NASA Astrophysics Data System (ADS)

    Min, Sung-Wook; Kim, Joohwan; Lee, Byoungho

    2005-03-01

    New three-dimensional (3D) display system which combines two different display techniques is proposed. One of the techniques is integral imaging. The integral imaging display system consists of a lens array and a 2D display device, and the 3D reconstructed images are integrated from the elemental images by the lens array. The other technique is image floating, which uses a big convex lens or a concave mirror to exhibit the image of a real object to the observer. The electro-floating display system which does not use the real object needs the volumetric 3D display part because the floating display system cannot make the 3D image, but only carries the image closer to the observer. The integral imaging display system can be adopted in the electro-floating display system, because the integrated image has the characteristics of the volumetric image within the viewing angle. Moreover, many methods to enhance the viewing angle of the integral imaging display system can be used for the proposed system directly. The proposed system can be successfully applied to many 3D applications such as 3D TV.

  12. Computer-assisted techniques for the verification of the Chebyshev property of Abelian integrals

    NASA Astrophysics Data System (ADS)

    Figueras, Jordi-Lluís; Tucker, Warwick; Villadelprat, Jordi

    We develop techniques for the verification of the Chebyshev property of Abelian integrals. These techniques are a combination of theoretical results, analysis of asymptotic behavior of Wronskians, and rigorous computations based on interval arithmetic. We apply this approach to tackle a conjecture formulated by Dumortier and Roussarie in [F. Dumortier, R. Roussarie, Birth of canard cycles, Discrete Contin. Dyn. Syst. 2 (2009) 723-781], which we are able to prove for q≤2.

  13. FTIR (Fourier transform infrared) spectrophotometry for thin film monitors: Computer and equipment integration for enhanced capabilities

    SciTech Connect

    Cox, J.N.; Sedayao, J.; Shergill, G.; Villasol, R. ); Haaland, D.M. )

    1990-01-01

    Fourier transform infrared spectrophotometry (FTIR) is a valuable technique for monitoring thin films used in semiconductor device manufacture. Determinations of the constituent contents in borophosphosilicate (BPSG), phosphosilicate (PSG), silicon oxynitride (SiON:H,OH), and spin-on-glass (SOG) thin films are a few applications. Due to the nature of the technique, FTIR instrumentation is one of the most extensively computer-dependent pieces of equipment that is likely to be found in a microelectronics plant. In the role of fab monitor or reactor characterization tool, FTIR instruments can rapidly generate large amounts of data. By linking a local FTIR data station to a remote minicomputer its capabilities are greatly improved. We discuss three caused of enhancement. First, the FTIR in the fab area communicates and interacts in real time with the minicomputer: transferring data segments to it, instructing it to perform sophisticated processing, and returning the result to the operator in the fab. Characterizations of PSG thin films by this approach are discussed. Second, the spectra of large numbers of samples are processed locally. The large database is then transmitted to the minicomputer for study by statistical/graphics software. Results of CVD-reactor spatial profiling experiments for plasma SiON are presented. Third, processing of calibration spectra is performed on the minicomputer to optimize the accuracy and precision of a Partial Least Squares'' analysis mode. This model is then transferred to the data station in the fab. The analysis of BPSG thin films is discussed in this regard. The prospects for fully automated at-line monitoring and for real-time, in-situ monitoring will be discussed. 10 refs., 4 figs.

  14. High security and robust optical image encryption approach based on computer-generated integral imaging pickup and iterative back-projection techniques

    NASA Astrophysics Data System (ADS)

    Li, Xiao Wei; Cho, Sung Jin; Kim, Seok Tae

    2014-04-01

    In this paper, a novel optical image encryption algorithm by combining the use of computer-generated integral imaging (CGII) pickup technique and iterative back-projection (IBP) technique is proposed. In this scheme, a color image to be encrypted which is firstly segregated into three channels: red, green, and blue. Each of these three channels is independently captured by using a virtual pinhole array and be computationally transformed as a sub-image array. Then, each of these three sub-image arrays are scrambled by the Fibonacci transformation (FT) algorithm, respectively. These three scrambled sub-image arrays are encrypted by the hybrid cellular automata (HCA), respectively. Ultimately, these three encrypted images are combined to produce the colored encrypted image. In the reconstruction process, because the computational integral imaging reconstruction (CIIR) is a pixel-overlapping reconstruction technique, the interference of the adjacent pixels will decrease the quality of the reconstructed image. To address this problem, we introduce an image super-resolution reconstruction technique, the image can be computationally reconstructed by the IBP technique. Some numerical simulations are made to test the validity and the capability of the proposed image encryption algorithm.

  15. Repair-dependent cell radiation survival and transformation: an integrated theory.

    PubMed

    Sutherland, John C

    2014-09-01

    The repair-dependent model of cell radiation survival is extended to include radiation-induced transformations. The probability of transformation is presumed to scale with the number of potentially lethal damages that are repaired in a surviving cell or the interactions of such damages. The theory predicts that at doses corresponding to high survival, the transformation frequency is the sum of simple polynomial functions of dose; linear, quadratic, etc, essentially as described in widely used linear-quadratic expressions. At high doses, corresponding to low survival, the ratio of transformed to surviving cells asymptotically approaches an upper limit. The low dose fundamental- and high dose plateau domains are separated by a downwardly concave transition region. Published transformation data for mammalian cells show the high-dose plateaus predicted by the repair-dependent model for both ultraviolet and ionizing radiation. For the neoplastic transformation experiments that were analyzed, the data can be fit with only the repair-dependent quadratic function. At low doses, the transformation frequency is strictly quadratic, but becomes sigmodial over a wider range of doses. Inclusion of data from the transition region in a traditional linear-quadratic analysis of neoplastic transformation frequency data can exaggerate the magnitude of, or create the appearance of, a linear component. Quantitative analysis of survival and transformation data shows good agreement for ultraviolet radiation; the shapes of the transformation components can be predicted from survival data. For ionizing radiations, both neutrons and x-rays, survival data overestimate the transforming ability for low to moderate doses. The presumed cause of this difference is that, unlike UV photons, a single x-ray or neutron may generate more than one lethal damage in a cell, so the distribution of such damages in the population is not accurately described by Poisson statistics. However, the complete

  16. Feature extraction and classification for EEG signals using wavelet transform and machine learning techniques.

    PubMed

    Amin, Hafeez Ullah; Malik, Aamir Saeed; Ahmad, Rana Fayyaz; Badruddin, Nasreen; Kamel, Nidal; Hussain, Muhammad; Chooi, Weng-Tink

    2015-03-01

    This paper describes a discrete wavelet transform-based feature extraction scheme for the classification of EEG signals. In this scheme, the discrete wavelet transform is applied on EEG signals and the relative wavelet energy is calculated in terms of detailed coefficients and the approximation coefficients of the last decomposition level. The extracted relative wavelet energy features are passed to classifiers for the classification purpose. The EEG dataset employed for the validation of the proposed method consisted of two classes: (1) the EEG signals recorded during the complex cognitive task--Raven's advance progressive metric test and (2) the EEG signals recorded in rest condition--eyes open. The performance of four different classifiers was evaluated with four performance measures, i.e., accuracy, sensitivity, specificity and precision values. The accuracy was achieved above 98 % by the support vector machine, multi-layer perceptron and the K-nearest neighbor classifiers with approximation (A4) and detailed coefficients (D4), which represent the frequency range of 0.53-3.06 and 3.06-6.12 Hz, respectively. The findings of this study demonstrated that the proposed feature extraction approach has the potential to classify the EEG signals recorded during a complex cognitive task by achieving a high accuracy rate.

  17. Integrating Fundamental Principles Underlying Somatic Practices into the Dance Technique Class

    ERIC Educational Resources Information Center

    Brodie, Julie; Lobel, Elin

    2004-01-01

    Integrating somatic practices into the dance technique class by bringing awareness to the bodily processes of breathing, sensing, connecting, and initiating can help students reconnect the mind with the body within the context of the classroom environment. Dance educators do not always have the resources to implement separate somatics courses…

  18. Effects of Cooperative Integrated Reading and Composition (CIRC) Technique on Reading-Writing Skills

    ERIC Educational Resources Information Center

    Durukan, Erhan

    2011-01-01

    The aim of this study was to analyze the effects of the cooperative integrated reading and composition (CIRC) technique and the traditional reading and writing pedagogical methods for primary school students. The study group was composed of 45 7th grade students enrolled at a primary school at the centre of Giresun Province in the 2009/2010…

  19. On preconditioning techniques for dense linear systems arising from singular boundary integral equations

    SciTech Connect

    Chen, Ke

    1996-12-31

    We study various preconditioning techniques for the iterative solution of boundary integral equations, and aim to provide a theory for a class of sparse preconditioners. Two related ideas are explored here: singularity separation and inverse approximation. Our preliminary conclusion is that singularity separation based preconditioners perform better than approximate inverse based while it is desirable to have both features.

  20. Computation of dynamic stress intensity factors using the boundary element method based on Laplace transform and regularized boundary integral equations

    NASA Astrophysics Data System (ADS)

    Tanaka, Masataka; Nakamura, Masayuki; Aoki, Kazuhiko; Matsumoto, Toshiro

    1993-07-01

    This paper presents a computational method of dynamic stress intensity factors (DSIF) in two-dimensional problems. In order to obtain accurate numerical results of DSIF, the boundary element method based on the Laplace transform and regularized boundary integral equations is applied to the computation of transient elastodynamic responses. A computer program is newly developed for two-dimensional elastodynamics. Numerical computation of DSIF is carried out for a rectangular plate with a center crack under impact tension. Accuracy of the results is investigated from the viewpoint of computational conditions such as the number of sampling points of the inverse Laplace transform and the number of boundary elements.

  1. Spherical integral transforms of second-order gravitational tensor components onto third-order gravitational tensor components

    NASA Astrophysics Data System (ADS)

    Šprlák, Michal; Novák, Pavel

    2016-10-01

    New spherical integral formulas between components of the second- and third-order gravitational tensors are formulated in this article. First, we review the nomenclature and basic properties of the second- and third-order gravitational tensors. Initial points of mathematical derivations, i.e., the second- and third-order differential operators defined in the spherical local North-oriented reference frame and the analytical solutions of the gradiometric boundary-value problem, are also summarized. Secondly, we apply the third-order differential operators to the analytical solutions of the gradiometric boundary-value problem which gives 30 new integral formulas transforming (1) vertical-vertical, (2) vertical-horizontal and (3) horizontal-horizontal second-order gravitational tensor components onto their third-order counterparts. Using spherical polar coordinates related sub-integral kernels can efficiently be decomposed into azimuthal and isotropic parts. Both spectral and closed forms of the isotropic kernels are provided and their limits are investigated. Thirdly, numerical experiments are performed to test the consistency of the new integral transforms and to investigate properties of the sub-integral kernels. The new mathematical apparatus is valid for any harmonic potential field and may be exploited, e.g., when gravitational/magnetic second- and third-order tensor components become available in the future. The new integral formulas also extend the well-known Meissl diagram and enrich the theoretical apparatus of geodesy.

  2. Development of in situ observation technique using scanning ion microscopy and demonstration of Mn depletion effect on intragranular ferrite transformation in low-alloy steel.

    PubMed

    Shigesato, Genichi; Sugiyama, Masaaki

    2002-01-01

    An in situ observation technique using scanning ion microscopy (SIM) to investigate the behaviour of phase transformation from austenite to ferrite in low-alloy steel is proposed. The most important advantage of the technique is the combined observation by SIM and fabrication by focused ion beam (FIB) at a wide range of temperature, from room temperature to 1673 K. Using this advantage, we have developed a new technique for observing intragranular ferrite (IGF) transformation in low-alloy steel, which is the phase transformation occurring at an inclusion existing inside a grain of austenite phase. We successfully observed the IGF transformation at 873 K by examining an inclusion exposed to the specimen surface by FIB fabrication at 1073 K during cooling from 1673 K. From the results of the in situ observation, we determined the role of Mn depletion due to precipitation of MnS for IGF transformation in steel.

  3. Nanowire humidity optical sensor system based on fast Fourier transform technique

    NASA Astrophysics Data System (ADS)

    Rota-Rodrigo, S.; Pérez-Herrera, R.; Lopez-Aldaba, A.; López Bautista, M. C.; Esteban, O.; López-Amo, M.

    2015-09-01

    In this paper, a new sensor system for relative humidity measurements based on its interaction with the evanescent field of a nanowire is presented. The interrogation of the sensing head is carried out by monitoring the fast Fourier transform phase variations of one of the nanowire interference frequencies. This method is independent of the signal amplitude and also avoids the necessity of tracking the wavelength evolution in the spectrum, which can be a handicap when there are multiple interference frequency components with different sensitivities. The sensor is operated within a wide humidity range (20%-70% relative humidity) with a maximum sensitivity achieved of 0.14rad/% relative humidity. Finally, due to the system uses an optical interrogator as unique active element, the system presents a cost-effective feature.

  4. Automated ambient desorption-ionization platform for surface imaging integrated with a commercial Fourier transform ion cyclotron resonance mass spectrometer.

    PubMed

    Pól, Jaroslav; Vidová, Veronika; Kruppa, Gary; Kobliha, Václav; Novák, Petr; Lemr, Karel; Kotiaho, Tapio; Kostiainen, Risto; Havlícek, Vladimír; Volný, Michael

    2009-10-15

    A fully automated atmospheric pressure ionization platform has been built and coupled with a commercial high-resolution Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS) instrument. The outstanding performance of this instrument allowed screening on the basis of exact masses in imaging mode. The main novel aspect was in the integration of the atmospheric pressure ionization imaging into the current software for matrix-assisted laser desorption ionization (MALDI) imaging, which allows the user of this commercial dual-source mass spectrometer to perform MALDI-MS and different ambient MS imaging from the same user interface and to utilize the same software tools. Desorption electrospray ionization (DESI) and desorption atmospheric pressure photoionization (DAPPI) were chosen to test the ambient surface imaging capabilities of this new ionization platform. Results of DESI imaging experiments performed on brain tissue sections are in agreement with previous MS imaging reports obtained by DESI imaging, but due to the high resolution and mass accuracy of the FTICR instrument it was possible to resolve several ions at the same nominal mass in the DESI-MS spectra of brain tissue. These isobaric interferences at low resolution are due to the overlap of ions from different lipid classes with different biological relevance. It was demonstrated that with the use of high-resolution MS fast imaging screening of lipids can be achieved without any preseparation steps. DAPPI, which is a relatively new and less developed ambient ionization technique compared to DESI, was used in imaging mode for the first time ever. It showed promise in imaging of phytocompounds from plant leaves, and selective ionization of a sterol lipid was achieved by DAPPI from a brain tissue sample.

  5. Nucleases Encoded by Integrated Elements CJIE2 and CJIE4 Inhibit Natural Transformation of Campylobacter jejuni

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The species Campylobacter jejuni displays huge genetic diversity, and is naturally competent for DNA uptake. Nevertheless, not every strain is able to acquire foreign DNA since nonnaturally transformable strains do exist. Previously we showed that many nonnaturally transformable C. jejuni strains ex...

  6. Technology and geomorphology: Are improvements in data collection techniques transforming geomorphic science?

    NASA Astrophysics Data System (ADS)

    Viles, Heather

    2016-10-01

    In recent years technological developments have revolutionized our ability to collect data in geomorphology. Enhanced data collection not only enables us to provide deeper answers to a wider range of fundamental questions about the Earth's surface, but also encourages us to pose new questions. This paper considers in more detail the relationships between science, technology and the development of geomorphological tools and techniques, reviews the spectrum of tools and techniques now available to geomorphologists, and critically assesses what impact 'new technologies' are having on geomorphology. It focuses on the role of technology in biogeomorphology and weathering research, and how it is advancing theoretical, empirical and applied dimensions of these growing sub-fields of geomorphology. Five areas of important technological development are reviewed: remote sensing, dating, geophysical techniques, field and laboratory based analysis and sensing of physical and chemical characteristics, and field and laboratory based analysis of biological properties. There is good evidence that, taken together, technological developments are revolutionizing geomorphology through opening the doors to better cross-scalar investigations, blurring the boundaries between laboratory, field and computer model, and facilitating cross-disciplinary and democratized research.

  7. Advanced Techniques for In-Situ Monitoring of Phase Transformations During Welding Using Synchrotron-Based X-Ray Diffraction

    SciTech Connect

    Elmer, J W; Palmer, T A; Zhang, W; DebRoy, T

    2005-06-05

    Understanding the evolution of microstructure in welds is an important goal of welding research because of the strong correlation between weld microstructure and weld properties. To achieve this goal it is important to develop a quantitative measure of phase transformations encountered during welding in order to ultimately develop methods for predicting weld microstructures from the characteristics of the welding process. To aid in this effort, synchrotron radiation methods have been developed at Lawrence Livermore National Laboratory (LLNL) for direct observation of microstructure evolution during welding. Using intense, highly collimated synchrotron radiation, the atomic structure of the weld heat affected and fusion zones can be probed in real time. Two synchrotron-based techniques, known as spatially resolved (SRXRD) and time resolved (TRXRD) x-ray diffraction, have been developed for these investigations. These techniques have now been used to investigate welding induced phase transformations in titanium alloys, low alloy steels, and stainless steel alloys. This paper will provide a brief overview of these methods and will discuss microstructural evolution during the welding of low carbon (AISI 1005) and medium carbon (AISI 1045) steels where the different levels of carbon influence the evolution of microstructures during welding.

  8. Large-scale symmetry-adapted perturbation theory computations via density fitting and Laplace transformation techniques: investigating the fundamental forces of DNA-intercalator interactions.

    PubMed

    Hohenstein, Edward G; Parrish, Robert M; Sherrill, C David; Turney, Justin M; Schaefer, Henry F

    2011-11-01

    Symmetry-adapted perturbation theory (SAPT) provides a means of probing the fundamental nature of intermolecular interactions. Low-orders of SAPT (here, SAPT0) are especially attractive since they provide qualitative (sometimes quantitative) results while remaining tractable for large systems. The application of density fitting and Laplace transformation techniques to SAPT0 can significantly reduce the expense associated with these computations and make even larger systems accessible. We present new factorizations of the SAPT0 equations with density-fitted two-electron integrals and the first application of Laplace transformations of energy denominators to SAPT. The improved scalability of the DF-SAPT0 implementation allows it to be applied to systems with more than 200 atoms and 2800 basis functions. The Laplace-transformed energy denominators are compared to analogous partial Cholesky decompositions of the energy denominator tensor. Application of our new DF-SAPT0 program to the intercalation of DNA by proflavine has allowed us to determine the nature of the proflavine-DNA interaction. Overall, the proflavine-DNA interaction contains important contributions from both electrostatics and dispersion. The energetics of the intercalator interaction are are dominated by the stacking interactions (two-thirds of the total), but contain important contributions from the intercalator-backbone interactions. It is hypothesized that the geometry of the complex will be determined by the interactions of the intercalator with the backbone, because by shifting toward one side of the backbone, the intercalator can form two long hydrogen-bonding type interactions. The long-range interactions between the intercalator and the next-nearest base pairs appear to be negligible, justifying the use of truncated DNA models in computational studies of intercalation interaction energies.

  9. An efficient watermarking technique for satellite images using discrete cosine transform

    NASA Astrophysics Data System (ADS)

    AL-Mansoori, Saeed

    2012-10-01

    Due to the significant progress in science and technology, the digital world became an interesting topic for many studies. "Data Security" is one of the main concepts related to the digital world especially in the field of remote sensing. Therefore, to deal with this matter the "Watermarking" concept was introduced. The idea of digital image watermarking is to embed the information within a signal (i.e. image, video, etc.), which cannot be easily extracted by a third party. This will generate a copyright protection and authentication for the owner(s). Emirates Institution for Advanced Science and Technology (EIAST) as an owner provides satellite images captured by DubaiSat-1 satellite to customers. The aim of this study is to implement a robust algorithm to hide EIAST logo within any delivered image in order to increase the data security and protect the ownership of DubaiSat-1 images. In addition, it is necessary to provide a high quality images to the end-user; nevertheless, adding any information (logo) to these images will affect its quality. Therefore, the model will be designed to keep the observable difference between the watermarked and original image at minimum. Moreover, the watermark should be difficult to remove or alter without the degradation of the host image. This study will be based on Discrete Cosine Transform (DCT) to provide an excellent and highly robust protection in cases such as noise addition, cropping, rotation and JPEG compression attacks.

  10. Tomography of homogenized laser-induced plasma by Radon transform technique

    NASA Astrophysics Data System (ADS)

    Eschlböck-Fuchs, S.; Demidov, A.; Gornushkin, I. B.; Schmid, T.; Rössler, R.; Huber, N.; Panne, U.; Pedarnig, J. D.

    2016-09-01

    Tomography of a laser-induced plasma in air is performed by inverse Radon transform of angle-resolved plasma images. Plasmas were induced by single laser pulses (SP), double pulses (DP) in collinear geometry, and by a combination of single laser pulses with pulsed arc discharges (SP-AD). Images of plasmas on metallurgical steel slags were taken at delay times suitable for calibration-free laser-induced breakdown spectroscopy (CF-LIBS). Delays ranged from few microseconds for SP and DP up to tens of microseconds for SP-AD excitation. The white-light and the spectrally resolved emissivity ε(x,y,z) was reconstructed for the three plasma excitation schemes. The electron number density Ne(x,y,z) and plasma temperature Te(x,y,z) were determined from Mg and Mn emission lines in reconstructed spectra employing the Saha-Boltzmann plot method. The SP plasma revealed strongly inhomogeneous emissivity and plasma temperature. Re-excitation of plasma by a second laser pulse (DP) and by an arc discharge (SP-AD) homogenized the plasma and reduced the spatial variation of ε and Te. The homogenization of a plasma is a promising approach to increase the accuracy of calibration-free LIBS analysis of complex materials.

  11. Damage Modes Recognition and Hilbert-Huang Transform Analyses of CFRP Laminates Utilizing Acoustic Emission Technique

    NASA Astrophysics Data System (ADS)

    WenQin, Han; Ying, Luo; AiJun, Gu; Yuan, Fuh-Gwo

    2016-04-01

    Discrimination of acoustic emission (AE) signals related to different damage modes is of great importance in carbon fiber-reinforced plastic (CFRP) composite materials. To gain a deeper understanding of the initiation, growth and evolution of the different types of damage, four types of specimens for different lay-ups and orientations and three types of specimens for interlaminar toughness tests are subjected to tensile test along with acoustic emission monitoring. AE signals have been collected and post-processed, the statistical results show that the peak frequency of AE signal can distinguish various damage modes effectively. After a AE signal were decomposed by Empirical Mode Decomposition (EMD) method, it may separate and extract all damage modes included in this AE signal apart from damage mode corresponding to the peak frequency. Hilbert-Huang Transform (HHT) of AE signals can clearly illustrate the frequency distribution of Intrinsic Mode Functions (IMF) components in time-scale in different damage stages, and can calculate accurate instantaneous frequency for damage modes recognition to help understanding the damage process.

  12. Writing trace identification using ultraviolet Fourier-transform imaging spectroscopy technique

    NASA Astrophysics Data System (ADS)

    Lyu, Hang; Liao, Ningfang; Wu, Wenmin; Li, Yasheng; Cao, Bin

    2015-08-01

    Conventional identification methods of writing traces commonly utilize imaging or spectroscopic techniques which work in visible to near infrared range or short-wave infrared range. Yet they cannot be applied in identifying the erased writing traces. In this study, we perform a research in identification of erased writing traces applying an ultraviolet Fouriertransform imaging spectrometer. Experiments of classifying the reflected ultraviolet spectra of erasable pens are made. The resulting hyperspectral images demonstrate that the erased writing traces on printing paper can be clearly identified by this ultraviolet imaging spectrometer.

  13. Design techniques for modular integrated utility systems. [energy production and conversion efficiency

    NASA Technical Reports Server (NTRS)

    Wolfer, B. M.

    1977-01-01

    Features basic to the integrated utility system, such as solid waste incineration, heat recovery and usage, and water recycling/treatment, are compared in terms of cost, fuel conservation, and efficiency to conventional utility systems in the same mean-climatic area of Washington, D. C. The larger of the two apartment complexes selected for the test showed the more favorable results in the three areas of comparison. Restrictions concerning the sole use of currently available technology are hypothetically removed to consider the introduction and possible advantages of certain advanced techniques in an integrated utility system; recommendations are made and costs are estimated for each type of system.

  14. Estimation of convective rain volumes utilizing the are-time-integral technique

    NASA Technical Reports Server (NTRS)

    Johnson, L. Ronald; Smith, Paul L.

    1990-01-01

    Interest in the possibility of developing useful estimates of convective rainfall with Area-Time Integral (ATI) methods is increasing. The basis of the ATI technique is the observed strong correlation between rainfall volumes and ATI values. This means that rainfall can be estimated by just determining the ATI values, if previous knowledge of the relationship to rain volume is available to calibrate the technique. Examples are provided of the application of the ATI approach to gage, radar, and satellite measurements. For radar data, the degree of transferability in time and among geographical areas is examined. Recent results on transferability of the satellite ATI calculations are presented.

  15. DNA Integrity and Shock Wave Transformation Efficiency of Bacteria and Fungi

    NASA Astrophysics Data System (ADS)

    Loske, Achim M.; Campos-Guillén, Juan; Fernández, Francisco; Pastrana, Xóchitl; Magaña-Ortíz, Denis; Coconi-Linares, Nancy; Ortíz-Vázquez, Elizabeth; Gómez-Lim, Miguel

    Delivery of DNA into bacteria and fungi is essential in medicine and biotechnology to produce metabolites, enzymes, antibiotics and proteins. So far, protocols to genetically transform bacteria and fungi are inefficient and have low reproducibility.

  16. An alignment and integration technique for mirror segment pairs on the Constellation-X telescope

    NASA Astrophysics Data System (ADS)

    Hadjimichael, Theo; Owens, Scott; Lehan, John; Olsen, Larry; Saha, Timo; Wallace, Tom; Zhang, Will

    2007-09-01

    We present the concepts behind the current alignment and integration technique for a Constellation-X primary-secondary mirror segment pair prior to an x-ray beam line test. We examine the effects of a passive mount on thin glass x-ray mirror segments, and the issues of mount shape and environment on alignment. We also investigate how bonding and transfer to a permanent housing affects the quality of the final image.

  17. Fast iterative, coupled-integral-equation technique for inhomogeneous profiled and periodic slabs.

    PubMed

    Magath, Thore; Serebryannikov, Andriy E

    2005-11-01

    A fast coupled-integral-equation (CIE) technique is developed to compute the plane-TE-wave scattering by a wide class of periodic 2D inhomogeneous structures with curvilinear boundaries, which includes finite-thickness relief and rod gratings made of homogeneous material as special cases. The CIEs in the spectral domain are derived from the standard volume electric field integral equation. The kernel of the CIEs is of Picard type and offers therefore the possibility of deriving recursions, which allow the computation of the convolution integrals occurring in the CIEs with linear amounts of arithmetic complexity and memory. To utilize this advantage, the CIEs are solved iteratively. We apply the biconjugate gradient stabilized method. To make the iterative solution process faster, an efficient preconditioning operator (PO) is proposed that is based on a formal analytical inversion of the CIEs. The application of the PO also takes only linear complexity and memory. Numerical studies are carried out to demonstrate the potential and flexibility of the CIE technique proposed. Though the best efficiency and accuracy are observed at either low permittivity contrast or high conductivity, the technique can be used in a wide range of variation of material parameters of the structures including when they contain components made of both dielectrics with high permittivity and typical metals.

  18. Fast iterative, coupled-integral-equation technique for inhomogeneous profiled and periodic slabs

    NASA Astrophysics Data System (ADS)

    Magath, Thore; Serebryannikov, Andriyâ E.

    2005-11-01

    A fast coupled-integral-equation (CIE) technique is developed to compute the plane-TE-wave scattering by a wide class of periodic 2D inhomogeneous structures with curvilinear boundaries, which includes finite-thickness relief and rod gratings made of homogeneous material as special cases. The CIEs in the spectral domain are derived from the standard volume electric field integral equation. The kernel of the CIEs is of Picard type and offers therefore the possibility of deriving recursions, which allow the computation of the convolution integrals occurring in the CIEs with linear amounts of arithmetic complexity and memory. To utilize this advantage, the CIEs are solved iteratively. We apply the biconjugate gradient stabilized method. To make the iterative solution process faster, an efficient preconditioning operator (PO) is proposed that is based on a formal analytical inversion of the CIEs. The application of the PO also takes only linear complexity and memory. Numerical studies are carried out to demonstrate the potential and flexibility of the CIE technique proposed. Though the best efficiency and accuracy are observed at either low permittivity contrast or high conductivity, the technique can be used in a wide range of variation of material parameters of the structures including when they contain components made of both dielectrics with high permittivity and typical metals.

  19. A point implicit time integration technique for slow transient flow problems

    SciTech Connect

    Kadioglu, Samet Y.; Berry, Ray A.; Martineau, Richard C.

    2015-05-01

    We introduce a point implicit time integration technique for slow transient flow problems. The method treats the solution variables of interest (that can be located at cell centers, cell edges, or cell nodes) implicitly and the rest of the information related to same or other variables are handled explicitly. The method does not require implicit iteration; instead it time advances the solutions in a similar spirit to explicit methods, except it involves a few additional function(s) evaluation steps. Moreover, the method is unconditionally stable, as a fully implicit method would be. This new approach exhibits the simplicity of implementation of explicit methods and the stability of implicit methods. It is specifically designed for slow transient flow problems of long duration wherein one would like to perform time integrations with very large time steps. Because the method can be time inaccurate for fast transient problems, particularly with larger time steps, an appropriate solution strategy for a problem that evolves from a fast to a slow transient would be to integrate the fast transient with an explicit or semi-implicit technique and then switch to this point implicit method as soon as the time variation slows sufficiently. We have solved several test problems that result from scalar or systems of flow equations. Our findings indicate the new method can integrate slow transient problems very efficiently; and its implementation is very robust.

  20. Learning-based computing techniques in geoid modeling for precise height transformation

    NASA Astrophysics Data System (ADS)

    Erol, B.; Erol, S.

    2013-03-01

    Precise determination of local geoid is of particular importance for establishing height control in geodetic GNSS applications, since the classical leveling technique is too laborious. A geoid model can be accurately obtained employing properly distributed benchmarks having GNSS and leveling observations using an appropriate computing algorithm. Besides the classical multivariable polynomial regression equations (MPRE), this study attempts an evaluation of learning based computing algorithms: artificial neural networks (ANNs), adaptive network-based fuzzy inference system (ANFIS) and especially the wavelet neural networks (WNNs) approach in geoid surface approximation. These algorithms were developed parallel to advances in computer technologies and recently have been used for solving complex nonlinear problems of many applications. However, they are rather new in dealing with precise modeling problem of the Earth gravity field. In the scope of the study, these methods were applied to Istanbul GPS Triangulation Network data. The performances of the methods were assessed considering the validation results of the geoid models at the observation points. In conclusion the ANFIS and WNN revealed higher prediction accuracies compared to ANN and MPRE methods. Beside the prediction capabilities, these methods were also compared and discussed from the practical point of view in conclusions.

  1. Super-resolution technique for CW lidar using Fourier transform reordering and Richardson-Lucy deconvolution.

    PubMed

    Campbell, Joel F; Lin, Bing; Nehrir, Amin R; Harrison, F Wallace; Obland, Michael D

    2014-12-15

    An interpolation method is described for range measurements of high precision altimetry with repeating intensity modulated continuous wave (IM-CW) lidar waveforms using binary phase shift keying (BPSK), where the range profile is determined by means of a cross-correlation between the digital form of the transmitted signal and the digitized return signal collected by the lidar receiver. This method uses reordering of the array elements in the frequency domain to convert a repeating synthetic pulse signal to single highly interpolated pulse. This is then enhanced further using Richardson-Lucy deconvolution to greatly enhance the resolution of the pulse. We show the sampling resolution and pulse width can be enhanced by about two orders of magnitude using the signal processing algorithms presented, thus breaking the fundamental resolution limit for BPSK modulation of a particular bandwidth and bit rate. We demonstrate the usefulness of this technique for determining cloud and tree canopy thicknesses far beyond this fundamental limit in a lidar not designed for this purpose. PMID:25503046

  2. Outlier and target detection in aerial hyperspectral imagery: a comparison of traditional and percentage occupancy hit or miss transform techniques

    NASA Astrophysics Data System (ADS)

    Young, Andrew; Marshall, Stephen; Gray, Alison

    2016-05-01

    The use of aerial hyperspectral imagery for the purpose of remote sensing is a rapidly growing research area. Currently, targets are generally detected by looking for distinct spectral features of the objects under surveillance. For example, a camouflaged vehicle, deliberately designed to blend into background trees and grass in the visible spectrum, can be revealed using spectral features in the near-infrared spectrum. This work aims to develop improved target detection methods, using a two-stage approach, firstly by development of a physics-based atmospheric correction algorithm to convert radiance into re ectance hyperspectral image data and secondly by use of improved outlier detection techniques. In this paper the use of the Percentage Occupancy Hit or Miss Transform is explored to provide an automated method for target detection in aerial hyperspectral imagery.

  3. An Integrated Backscatter Ultrasound Technique for the Detection of Coronary and Carotid Atherosclerotic Lesions

    PubMed Central

    Kawasaki, Masanori

    2015-01-01

    The instability of carotid and coronary plaques has been reported to be associated with acute coronary syndrome, strokes and other cerebrovascular events. Therefore, recognition of the tissue characteristics of carotid and coronary plaques is important to understand and prevent coronary and cerebral artery disease. Recently, an ultrasound integrated backscatter (IB) technique has been developed. The ultrasound IB power ratio is a function of the difference in acoustic characteristic impedance between the medium and target tissue, and the acoustic characteristic impedance is determined by the density of tissue multiplied by the speed of sound. This concept allows for tissue characterization of carotid and coronary plaques for risk stratification of patients with coronary and cerebral artery disease. Two- and three-dimensional IB color-coded maps for the evaluation of tissue components consist of four major components: fibrous, dense fibrosis, lipid pool and calcification. Although several ultrasound techniques using special mathematical algorithms have been reported, a growing body of literature has shown the reliability and usefulness of the IB technique for the tissue characterization of carotid and coronary plaques. This review summarizes concepts, experimental procedures, image reliability and the application of the IB technique. Furthermore, the IB technique is compared with other techniques. PMID:25574937

  4. HUNTER-GATHERER: Three search techniques integrated for natural language semantics

    SciTech Connect

    Beale, S.; Nirenburg, S.; Mahesh, K.

    1996-12-31

    This work integrates three related Al search techniques - constraint satisfaction, branch-and-bound and solution synthesis - and applies the result to semantic processing in natural language (NL). We summarize the approach as {open_quote}Hunter-Gatherer:{close_quotes} (1) branch-and-bound and constraint satisfaction allow us to {open_quote}hunt down{close_quotes} non-optimal and impossible solutions and prune them from the search space. (2) solution synthesis methods then {open_quote}gather{close_quotes} all optimal solutions avoiding exponential complexity. Each of the three techniques is briefly described, as well as their extensions and combinations used in our system. We focus on the combination of solution synthesis and branch-and-bound methods which has enabled near-linear-time processing in our applications. Finally, we illustrate how the use of our technique in a large-scale MT project allowed a drastic reduction in search space.

  5. Techniques for a Wind Energy System Integration with an Islanded Microgrid

    NASA Astrophysics Data System (ADS)

    Goyal, Megha; Fan, Yuanyuan; Ghosh, Arindam; Shahnia, Farhad

    2016-04-01

    This paper presents two different techniques of a wind energy conversion system (WECS) integration with an islanded microgrid (MG). The islanded microgrid operates in a frequency droop control where its frequency can vary around 50 Hz. The permanent magnet synchronous generator (PMSG) based variable speed WECS is considered, which converts wind energy to a low frequency ac power. Therefore it needs to be connected to the microgrid through a back to back (B2B) converter system. One way of interconnection is to synchronize the MG side converter with the MG bus at which it is connected. In this case, this converter runs at the MG frequency. The other approach is to bring back the MG frequency to 50 Hz using the isochronization concept. In this case, the MG side converter operates at 50 Hz. Both these techniques are developed in this paper. The proposed techniques are validated through extensive PSCAD/EMTDC simulation studies.

  6. Polymer microlens array integrated with imaging sensors by UV-molding technique

    NASA Astrophysics Data System (ADS)

    Lai, Jianjun; Zhao, Yue; Ke, Caijun; Yi, Xinjian; Zhang, TianXu

    2005-01-01

    Fabrication of Polymer microlens array based on UV-molding techniques is presented. UV-molding enables for the integration of polymer microlens array on top of arbitrary substrates like glass, silicon other polymeric films. In this technique, photoresist or glass mold is first fabricated by conventional photolithnic method and subsequently served as transparent replication tool. UV curable polymer resin is then coated on patterned or unpatterned substrates and a contact mask aligner is used to align substrates and replication mold tool and then make the mold immersed into the resin. Replication of polymer on substrates is achieved by UV photopolymerisation of the resin. Resin thickness and gap distance between mold and substrate are carefully controlled in order to obtain acceptable thickness of cured polymer base. The UV molding technique was used to molding of a polymer film carring microlens array on the surface of an experimental CCD imaging sensor chip in this paper to enhance its fill factor and sensitivity.

  7. Propulsion Airframe Integration Test Techniques for Hypersonic Airbreathing Configurations at NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Witte, David W.; Huebner, Lawrence D.; Trexler, Carl A.; Cabell, Karen F.; Andrews, Earl H., Jr.

    2003-01-01

    The scope and significance of propulsion airframe integration (PAI) for hypersonic airbreathing vehicles is presented through a discussion of the PAI test techniques utilized at NASA Langley Research Center. Four primary types of PAI model tests utilized at NASA Langley for hypersonic airbreathing vehicles are discussed. The four types of PAI test models examined are the forebody/inlet test model, the partial-width/truncated propulsion flowpath test model, the powered exhaust simulation test model, and the full-length/width propulsion flowpath test model. The test technique for each of these four types of PAI test models is described, and the relevant PAI issues addressed by each test technique are illustrated through the presentation of recent PAI test data.

  8. Tomographic inversion techniques incorporating physical constraints for line integrated spectroscopy in stellarators and tokamaksa)

    DOE PAGESBeta

    Pablant, N. A.; Bell, R. E.; Bitter, M.; Delgado-Aparicio, L.; Hill, K. W.; Lazerson, S.; Morita, S.

    2014-08-08

    Accurate tomographic inversion is important for diagnostic systems on stellarators and tokamaks which rely on measurements of line integrated emission spectra. A tomographic inversion technique based on spline optimization with enforcement of constraints is described that can produce unique and physically relevant inversions even in situations with noisy or incomplete input data. This inversion technique is routinely used in the analysis of data from the x-ray imaging crystal spectrometer (XICS) installed at LHD. The XICS diagnostic records a 1D image of line integrated emission spectra from impurities in the plasma. Through the use of Doppler spectroscopy and tomographic inversion, XICSmore » can provide pro file measurements of the local emissivity, temperature and plasma flow. Tomographic inversion requires the assumption that these measured quantities are flux surface functions, and that a known plasma equilibrium reconstruction is available. In the case of low signal levels or partial spatial coverage of the plasma cross-section, standard inversion techniques utilizing matrix inversion and linear-regularization often cannot produce unique and physically relevant solutions. The addition of physical constraints, such as parameter ranges, derivative directions, and boundary conditions, allow for unique solutions to be reliably found. The constrained inversion technique described here utilizes a modifi ed Levenberg-Marquardt optimization scheme, which introduces a condition avoidance mechanism by selective reduction of search directions. The constrained inversion technique also allows for the addition of more complicated parameter dependencies, for example geometrical dependence of the emissivity due to asymmetries in the plasma density arising from fast rotation. The accuracy of this constrained inversion technique is discussed, with an emphasis on its applicability to systems with limited plasma coverage.« less

  9. Tomographic inversion techniques incorporating physical constraints for line integrated spectroscopy in stellarators and tokamaksa)

    SciTech Connect

    Pablant, N. A.; Bell, R. E.; Bitter, M.; Delgado-Aparicio, L.; Hill, K. W.; Lazerson, S.; Morita, S.

    2014-08-08

    Accurate tomographic inversion is important for diagnostic systems on stellarators and tokamaks which rely on measurements of line integrated emission spectra. A tomographic inversion technique based on spline optimization with enforcement of constraints is described that can produce unique and physically relevant inversions even in situations with noisy or incomplete input data. This inversion technique is routinely used in the analysis of data from the x-ray imaging crystal spectrometer (XICS) installed at LHD. The XICS diagnostic records a 1D image of line integrated emission spectra from impurities in the plasma. Through the use of Doppler spectroscopy and tomographic inversion, XICS can provide pro file measurements of the local emissivity, temperature and plasma flow. Tomographic inversion requires the assumption that these measured quantities are flux surface functions, and that a known plasma equilibrium reconstruction is available. In the case of low signal levels or partial spatial coverage of the plasma cross-section, standard inversion techniques utilizing matrix inversion and linear-regularization often cannot produce unique and physically relevant solutions. The addition of physical constraints, such as parameter ranges, derivative directions, and boundary conditions, allow for unique solutions to be reliably found. The constrained inversion technique described here utilizes a modifi ed Levenberg-Marquardt optimization scheme, which introduces a condition avoidance mechanism by selective reduction of search directions. The constrained inversion technique also allows for the addition of more complicated parameter dependencies, for example geometrical dependence of the emissivity due to asymmetries in the plasma density arising from fast rotation. The accuracy of this constrained inversion technique is discussed, with an emphasis on its applicability to systems with limited plasma coverage.

  10. Enhanced targeted integration mediated by translocated I-SceI during the Agrobacterium mediated transformation of yeast.

    PubMed

    Rolloos, Martijn; Hooykaas, Paul J J; van der Zaal, Bert J

    2015-02-09

    Agrobacterium mediated transformation (AMT) has been embraced by biotechnologists as the technology of choice to introduce or alter genetic traits of plants. However, in plants it is virtually impossible to predetermine the integration site of the transferred T-strand unless one is able to generate a double stranded break (DSB) in the DNA at the site of interest. In this study, we used the model organism Saccharomyces cerevisiae to investigate whether the Agrobacterium mediated translocation of site-specific endonucleases via the type IV secretion system (T4SS), concomitantly with T-DNA transfer is possible and whether this can improve the gene targeting efficiency. In addition to that, the effect of different chromatin states on targeted integration, was investigated. It was found that Agrobacterium mediated translocation of the homing endonuclease I-SceI has a positive effect on the integration of T-DNA via the homologous repair (HR) pathway. Furthermore, we obtained evidence that nucleosome removal has a positive effect on I-SceI facilitated T-DNA integration by HR. Reversely; inducing nucleosome formation at the site of integration removes the positive effect of translocated I-SceI on T-DNA integration.

  11. Integrator Windup Protection-Techniques and a STOVL Aircraft Engine Controller Application

    NASA Technical Reports Server (NTRS)

    KrishnaKumar, K.; Narayanaswamy, S.

    1997-01-01

    Integrators are included in the feedback loop of a control system to eliminate the steady state errors in the commanded variables. The integrator windup problem arises if the control actuators encounter operational limits before the steady state errors are driven to zero by the integrator. The typical effects of windup are large system oscillations, high steady state error, and a delayed system response following the windup. In this study, methods to prevent the integrator windup are examined to provide Integrator Windup Protection (IW) for an engine controller of a Short Take-Off and Vertical Landing (STOVL) aircraft. An unified performance index is defined to optimize the performance of the Conventional Anti-Windup (CAW) and the Modified Anti-Windup (MAW) methods. A modified Genetic Algorithm search procedure with stochastic parameter encoding is implemented to obtain the optimal parameters of the CAW scheme. The advantages and drawbacks of the CAW and MAW techniques are discussed and recommendations are made for the choice of the IWP scheme, given some characteristics of the system.

  12. A novel integrated active capping technique for the remediation of nitrobenzene-contaminated sediment.

    PubMed

    Sun, Hongwen; Xu, Xiaoyang; Gao, Guandao; Zhang, Zizhong; Yin, Peijie

    2010-10-15

    The objective of this study was to develop a novel integrated active capping system and to investigate its efficiency in the remediation of nitrobenzene-contaminated sediment. An integrated Fe(0)-sorbent-microorganism remediation system was proposed as an in situ active capping technique to remediate nitrobenzene-contaminated sediment. In this system, nitrobenzene was reduced to aniline by Fe(0), which has a much better biodegradability. The sorption capacity and structural properties of cinder was measured to examine its applicability as the sorbent and matrix for this integrated capping system. Indigenous microorganisms from Songhuajiang River sediment, which was contaminated by nitrobenzene and aniline in Chinese Petrochemical Explosion in Jilin, were acquired one month after the explosion and used in this active capping system to degrade nitrobenzene and its reduced product, aniline. A bench-scale remediation experiment was conducted on a mimicked nitrobenzene-contaminated sediment to investigate the efficiency of the integrated capping system and the synergistic effects of the combined components in the active capping system. The results show that this integrated active capping system can effectively block the release of target pollutants into the upper-layer water and remove the compounds from the environment.

  13. Integrated Deployment Model: A Comprehensive Approach to Transforming the Energy Economy

    SciTech Connect

    Werner, M.

    2010-11-01

    This paper describes the Integrated Deployment model to accelerate market adoption of alternative energy solutions to power homes, businesses, and vehicles through a comprehensive and aggressive approach.

  14. Transforming Pedagogies: Integrating 21st Century Skills and Web 2.0 Technology

    ERIC Educational Resources Information Center

    Tucker, Shelia Y.

    2014-01-01

    According to (P21), Partnership for 21st Century Skills (n.d.), unless the gap is bridged between how students learn and how they live, today's education system will face irrelevance. The way people work and live has been transformed by demographic, economic, political, technological, and informational forces. Schools must adapt to these…

  15. 76 FR 17145 - Agency Information Collection Activities: Business Transformation-Automated Integrated Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Business... (202) 272-8377. Background: U.S. Citizenship and Immigration Services (USCIS) is transforming its... ] sponsoring the collection: No form number; U.S. Citizenship and Immigration Services (USCIS). (4)...

  16. Cancer Cell Stiffness: Integrated Roles of Three-Dimensional Matrix Stiffness and Transforming Potential

    PubMed Central

    Baker, Erin L.; Lu, Jing; Yu, Dihua; Bonnecaze, Roger T.; Zaman, Muhammad H.

    2010-01-01

    While significant advances have been made toward revealing the molecular mechanisms that influence breast cancer progression, much less is known about the associated cellular mechanical properties. To this end, we use particle-tracking microrheology to investigate the interplay among intracellular mechanics, three-dimensional matrix stiffness, and transforming potential in a mammary epithelial cell (MEC) cancer progression series. We use a well-characterized model system where human-derived MCF10A MECs overexpress either ErbB2, 14-3-3ζ, or both ErbB2 and 14-3-3ζ, with empty vector as a control. Our results show that MECs possessing ErbB2 transforming potential stiffen in response to elevated matrix stiffness, whereas non-transformed MECs or those overexpressing only 14-3-3ζ do no exhibit this response. We further observe that overexpression of ErbB2 alone is associated with the highest degree of intracellular sensitivity to matrix stiffness, and that the effect of transforming potential on intracellular stiffness is matrix-stiffness-dependent. Moreover, our intracellular stiffness measurements parallel cell migration behavior that has been previously reported for these MEC sublines. Given the current knowledge base of breast cancer mechanobiology, these findings suggest that there may be a positive relationship among intracellular stiffness sensitivity, cell motility, and perturbed mechanotransduction in breast cancer. PMID:20923638

  17. A DNase encoded by integrated element CJIE1 inhibits natural transformation of Campylobacter jejuni

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The species Campylobacter jejuni (C. jejuni) is considered naturally competent for DNA uptake and displays strong genetic diversity. Yet, non-transformable strains and several relatively stable clonal lineages exist. In the present study, the molecular mechanism responsible for the non-transformabil...

  18. Cancer cell stiffness: integrated roles of three-dimensional matrix stiffness and transforming potential.

    PubMed

    Baker, Erin L; Lu, Jing; Yu, Dihua; Bonnecaze, Roger T; Zaman, Muhammad H

    2010-10-01

    While significant advances have been made toward revealing the molecular mechanisms that influence breast cancer progression, much less is known about the associated cellular mechanical properties. To this end, we use particle-tracking microrheology to investigate the interplay among intracellular mechanics, three-dimensional matrix stiffness, and transforming potential in a mammary epithelial cell (MEC) cancer progression series. We use a well-characterized model system where human-derived MCF10A MECs overexpress either ErbB2, 14-3-3ζ, or both ErbB2 and 14-3-3ζ, with empty vector as a control. Our results show that MECs possessing ErbB2 transforming potential stiffen in response to elevated matrix stiffness, whereas non-transformed MECs or those overexpressing only 14-3-3ζ do no exhibit this response. We further observe that overexpression of ErbB2 alone is associated with the highest degree of intracellular sensitivity to matrix stiffness, and that the effect of transforming potential on intracellular stiffness is matrix-stiffness-dependent. Moreover, our intracellular stiffness measurements parallel cell migration behavior that has been previously reported for these MEC sublines. Given the current knowledge base of breast cancer mechanobiology, these findings suggest that there may be a positive relationship among intracellular stiffness sensitivity, cell motility, and perturbed mechanotransduction in breast cancer.

  19. Transforming University Practice through ICT--Integrated Perspectives on Organizational, Technological, and Pedagogical Change

    ERIC Educational Resources Information Center

    Dirckinck-Holmfeld, Lone; Lorentsen, Annette

    2003-01-01

    The article focuses on the use of information and communication technology (ICT) for strengthening and transforming university practice in line with the social and technological conditions of the new ideas for "interactive" universities. The purpose is to use ICT as a change-agent in order to establish new practices--new pedagogical methods, new…

  20. Study of {sup 3}He(e,e{prime}) longitudinal response functions with the integral-transform method

    SciTech Connect

    Dobretsov, V.Yu.; Efros, V.D.; Shao, B.

    1995-09-01

    The method of integral transforms is first applied to study of the {sup 3}He longitudinal response functions. The transforms are calculated from localized bound-state type solutions to an inhomogenous three-body equation. {sup 3}N dynamics and the conventional charge density operator serve as an input. The final-state interaction the contribution of the T = 3/2 final states to the problem suppressed and amounts to about 15%. This might be ascribed to symmetry properties of the final-state wave functions. The contributions of the p-wave N/N interaction and of the Coulomb interaction to the problem are studied and found to amount to several percent. Uncertainties due to different choices of s-wave NN forces are found to be of a similar magnitude. For q = 300 MeV/c, the results obtained agree with experiment. For q = 500 MeV/c, noticeable differences are detected. 20 refs., 3 figs.

  1. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy: An analytical technique to understand therapeutic responses at the molecular level

    PubMed Central

    Kalmodia, Sushma; Parameswaran, Sowmya; Yang, Wenrong; Barrow, Colin J.; Krishnakumar, Subramanian

    2015-01-01

    Rapid monitoring of the response to treatment in cancer patients is essential to predict the outcome of the therapeutic regimen early in the course of the treatment. The conventional methods are laborious, time-consuming, subjective and lack the ability to study different biomolecules and their interactions, simultaneously. Since; mechanisms of cancer and its response to therapy is dependent on molecular interactions and not on single biomolecules, an assay capable of studying molecular interactions as a whole, is preferred. Fourier Transform Infrared (FTIR) spectroscopy has become a popular technique in the field of cancer therapy with an ability to elucidate molecular interactions. The aim of this study, was to explore the utility of the FTIR technique along with multivariate analysis to understand whether the method has the resolution to identify the differences in the mechanism of therapeutic response. Towards achieving the aim, we utilized the mouse xenograft model of retinoblastoma and nanoparticle mediated targeted therapy. The results indicate that the mechanism underlying the response differed between the treated and untreated group which can be elucidated by unique spectral signatures generated by each group. The study establishes the efficiency of non-invasive, label-free and rapid FTIR method in assessing the interactions of nanoparticles with cellular macromolecules towards monitoring the response to cancer therapeutics. PMID:26568521

  2. Quantitative Integration of Multiple Geophysical Techniques for Reducing Uncertainty in Discrete Anomaly Detection

    NASA Astrophysics Data System (ADS)

    Carr, M. C.; Baker, G. S.; Herrmann, N.; Yerka, S.; Angst, M.

    2008-12-01

    The objectives of this project are to (1) utilize quantitative integration of multiple geophysical techniques, (2) determine geophysical anomalies that may indicate locations of various archaeological structures, and (3) develop techniques of quantifying causes of uncertainty. Two sites are used to satisfy these objectives. The first, representing a site with unknown target features, is an archaeological site on the Tennessee River floodplain. The area is divided into 437 (20 x 20 m) plots with 0.5 m spacing where magnetic gradiometry profiles were collected in a zig-zag pattern, resulting in 350 km of line data. Once anomalies are identified in the magnetics data, potential excavation sites for archeological features are determined and other geophysical techniques are utilized to gain confidence in choosing which anomalies to excavate. Several grids are resurveyed using Ground Penetrating Radar (GPR) and EM-31 with a 0.25 m spacing in a grid pattern. A quantitative method of integrating data into one comprehensive set is developed, enhancing interpretation because each geophysical technique utilized within this study produced a unique response to noise and the targets. Spatial visualization software is used to interpolate irregularly spaced XYZ data into a regularly spaced grid and display the geophysical data in 3D representations. Once all data are exported from each individual instrument, grid files are created for quantitative merging of the data and to create grid-based maps including contour, image, shaded relief, and surface maps. Statistics were calculated from anomaly classification in the data and excavated features present. To study this methodology in a more controlled setting, a second site is used. This site is analogous to the first in that it is along the Tennessee River floodplain on the same bedrock units. However, this analog site contains known targets (previously buried and accurately located) including size, shape, and orientation. Four

  3. Thermal Characterization of Anisotropic Materials at High Temperature Through Integral Methods and Localized Pulsed Technique

    NASA Astrophysics Data System (ADS)

    Souhar, Youssef; Rémy, Benjamin; Degiovanni, Alain

    2013-02-01

    New applications in aerospace or energy industries require the development of new materials at high temperature exhibiting high anisotropic properties. Their thermal characterization requires the development of specific experimental benches. In this article, a new experiment is presented which allows one to estimate through only one experiment the three diffusivities of an orthotropic material at high temperatures without the need of vacuum. The estimation procedure is very fast and accurate due to using, on the one hand, integral transforms that allows one to get rid of the spatial distribution of the flash energy, and on the other hand, an infrared camera that provides a large amount of experimental data. And thanks to the use of a nonlinear parameter estimation and estimations made directly on Fourier transforms of the temperature field, the heat flux stimulation is no longer necessary to be Dirac in time. To validate the method and the experimental facility, measurements were performed on a Ti-6Al-4V alloy from room temperature up to 1000 ^{circ }{ C }. In addition, particular attention has been paid to the thermal coupling that can appear between the low conducting materials and the air, and a criterion has been established to determine if the in-plane thermal diffusivity measurements can be affected or not.

  4. An integrated GPS-accelerometer data processing technique for structural deformation monitoring

    NASA Astrophysics Data System (ADS)

    Chan, W. S.; Xu, Y. L.; Ding, X. L.; Dai, W. J.

    2006-12-01

    Global Positioning System (GPS) is being actively applied to measure static and dynamic displacement responses of large civil engineering structures under winds. However, multipath effects and low sampling frequencies affect the accuracy of GPS for displacement measurement. On the other hand, accelerometers cannot reliably measure static and low-frequency structural responses, but can accurately measure high-frequency structural responses. Therefore, this paper explores the possibility of integrating GPS-measured signals with accelerometer-measured signals to enhance the measurement accuracy of total (static plus dynamic) displacement response of a structure. Integrated data processing techniques using both empirical mode decomposition (EMD) and an adaptive filter are presented. A series of motion simulation table tests are then performed at a site using three GPS receivers, one accelerometer, and one motion simulation table that can simulate various types of motion defined by input wave time histories around a pre-defined static position. The proposed data processing techniques are applied to the recorded GPS and accelerometer data to find both static and dynamic displacements. These results are compared with the actual displacement motions generated by the motion simulation table. The comparative results demonstrate that the proposed technique can significantly enhance the measurement accuracy of the total displacement of a structure.

  5. Small tumor virus genomes are integrated near nuclear matrix attachment regions in transformed cells.

    PubMed

    Shera, K A; Shera, C A; McDougall, J K

    2001-12-01

    More than 15% of human cancers have a viral etiology. In benign lesions induced by the small DNA tumor viruses, viral genomes are typically maintained extrachromosomally. Malignant progression is often associated with viral integration into host cell chromatin. To study the role of viral integration in tumorigenesis, we analyzed the positions of integrated viral genomes in tumors and tumor cell lines induced by the small oncogenic viruses, including the high-risk human papillomaviruses, hepatitis B virus, simian virus 40, and human T-cell leukemia virus type 1. We show that viral integrations in tumor cells lie near cellular sequences identified as nuclear matrix attachment regions (MARs), while integrations in nonneoplastic cells show no significant correlation with these regions. In mammalian cells, the nuclear matrix functions in gene expression and DNA replication. MARs play varied but poorly understood roles in eukaryotic gene expression. Our results suggest that integrated tumor virus genomes are subject to MAR-mediated transcriptional regulation, providing insight into mechanisms of viral carcinogenesis. Furthermore, the viral oncoproteins serve as invaluable tools for the study of mechanisms controlling cellular growth. Similarly, our demonstration that integrated viral genomes may be subject to MAR-mediated transcriptional effects should facilitate elucidation of fundamental mechanisms regulating eukaryotic gene expression.

  6. Integrable maps from Galois differential algebras, Borel transforms and number sequences

    NASA Astrophysics Data System (ADS)

    Tempesta, Piergiulio

    A new class of integrable maps, obtained as lattice versions of polynomial dynamical systems is introduced. These systems are obtained by means of a discretization procedure that preserves several analytic and algebraic properties of a given differential equation, in particular symmetries and integrability (see Tempesta, 2010 [40]). Our approach is based on the properties of a suitable Galois differential algebra, that we shall call a Rota algebra. A formulation of the procedure in terms of category theory is proposed. In order to render the lattice dynamics confined, a Borel regularization is also adopted. As a byproduct of the theory, a connection between number sequences and integrability is discussed.

  7. Fault tolerance techniques to assure data integrity in high-volume PACS image archives

    NASA Astrophysics Data System (ADS)

    He, Yutao; Huang, Lu J.; Valentino, Daniel J.; Wingate, W. Keith; Avizienis, Algirdas

    1995-05-01

    Picture archiving and communication systems (PACS) perform the systematic acquisition, archiving, and presentation of large quantities of radiological image and text data. In the UCLA Radiology PACS, for example, the volume of image data archived currently exceeds 2500 gigabytes. Furthermore, the distributed heterogeneous PACS is expected to have near real-time response, be continuously available, and assure the integrity and privacy of patient data. The off-the-shelf subsystems that compose the current PACS cannot meet these expectations; therefore fault tolerance techniques had to be incorporated into the system. This paper is to report our first-step efforts towards the goal and is organized as follows: First we discuss data integrity and identify fault classes under the PACS operational environment, then we describe auditing and accounting schemes developed for error-detection and analyze operational data collected. Finally, we outline plans for future research.

  8. Rolled-up transformer structure for a radiofrequency integrated circuit (RFIC)

    DOEpatents

    Li, Xiuling; Huang, Wen

    2015-01-27

    A rolled-up transformer structure comprises a multilayer sheet having a rolled configuration comprising multiple turns about a longitudinal axis. The multilayer sheet comprises more than one conductive pattern layer on a strain-relieved layer, including a first conductive film and a second conductive film separated from the first conductive film in a thickness direction. The first conductive film comprises an even number of primary conductive strips, where each primary conductive strip has a length extending in the rolling direction, and the second conductive film comprises an even number of secondary conductive strips, where each secondary conductive strip has a length extending in the rolling direction. In the rolled configuration, turns of the primary conductive strips and turns of the secondary conductive strips wrap around the longitudinal axis. The primary conductive strips serve as a primary winding and the secondary conductive strips serve as a secondary winding of the rolled-up transformer structure.

  9. Rolled-up transformer structure for a radiofrequency integrated circuit (RFIC)

    DOEpatents

    Li, Xiuling; Huang, Wen

    2016-05-03

    A rolled-up transformer structure comprises a multilayer sheet having a rolled configuration comprising multiple turns about a longitudinal axis. The multilayer sheet comprises more than one conductive pattern layer on a strain-relieved layer, including a first conductive film and a second conductive film separated from the first conductive film in a thickness direction. The first conductive film comprises an even number of primary conductive strips, where each primary conductive strip has a length extending in the rolling direction, and the second conductive film comprises an even number of secondary conductive strips, where each secondary conductive strip has a length extending in the rolling direction. In the rolled configuration, turns of the primary conductive strips and turns of the secondary conductive strips wrap around the longitudinal axis. The primary conductive strips serve as a primary winding and the secondary conductive strips serve as a secondary winding of the rolled-up transformer structure.

  10. Alignment and Integration Techniques for Mirror Segment Pairs on the Constellation X Telescope

    NASA Technical Reports Server (NTRS)

    Hadjimichael, Theo; Lehan, John; Olsen, Larry; Owens, Scott; Saha, Timo; Wallace, Tom; Zhang, Will

    2007-01-01

    We present the concepts behind current alignment and integration techniques for testing a Constellation-X primary-secondary mirror segment pair in an x-ray beam line test. We examine the effects of a passive mount on thin glass x-ray mirror segments, and the issues of mount shape and environment on alignment. We also investigate how bonding and transfer to a permanent housing affects the quality of the final image, comparing predicted results to a full x-ray test on a primary secondary pair.

  11. An integrated study of earth resources in the State of California using remote sensing techniques

    NASA Technical Reports Server (NTRS)

    Colwell, R. N.

    1972-01-01

    Remote sensing activities for the management of California's water project are reported. Integrated efforts are based largely on airborne remote sensing data processing to inventory the various kinds of earth resources observed. Work centered on defining parameters pertinent to determine water yield and discernible through remote sensing techniques; (2) determining accuracy in measuring and mapping parameters using remote sensing data flown to various specifications; and (3) relating water yield predictions to actual water yields. Remote sensing imagery of the Perris valley shows that land developers established a number of locations to promote present agricultural land for non-agricultural land use.

  12. Integrated Imaging and Vision Techniques for Industrial Inspection: A Special Issue on Machine Vision and Applications

    SciTech Connect

    Liu, Zheng; Ukida, H.; Ramuhalli, Pradeep; Forsyth, D. S.

    2010-06-05

    Imaging- and vision-based techniques play an important role in industrial inspection. The sophistication of the techniques assures high- quality performance of the manufacturing process through precise positioning, online monitoring, and real-time classification. Advanced systems incorporating multiple imaging and/or vision modalities provide robust solutions to complex situations and problems in industrial applications. A diverse range of industries, including aerospace, automotive, electronics, pharmaceutical, biomedical, semiconductor, and food/beverage, etc., have benefited from recent advances in multi-modal imaging, data fusion, and computer vision technologies. Many of the open problems in this context are in the general area of image analysis methodologies (preferably in an automated fashion). This editorial article introduces a special issue of this journal highlighting recent advances and demonstrating the successful applications of integrated imaging and vision technologies in industrial inspection.

  13. New integration techniques for chemical kinetic rate equations. 2: Accuracy comparison

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, K.

    1985-01-01

    A comparison of the accuracy of several techniques recently developed for solving stiff differential equations is presented. The techniques examined include two general purpose codes EEPISODE and LSODE developed for an arbitrary system of ordinary differential equations, and three specialized codes CHEMEQ, CREKID, and GCKP84 developed specifically to solve chemical kinetic rate equations. The accuracy comparisons are made by applying these solution procedures to two practical combustion kinetics problems. Both problems describe adiabatic, homogeneous, gas phase chemical reactions at constant pressure, and include all three combustion regimes: induction, heat release, and equilibration. The comparisons show that LSODE is the most efficient code - in the sense that it requires the least computational work to attain a specified accuracy level. An important finding is that an iterative solution of the algebraic enthalpy conservation equation for the temperature can be more accurate and efficient than computing the temperature by integrating its time derivative.

  14. New integration techniques for chemical kinetic rate equations. II - Accuracy comparison

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, K.

    1986-01-01

    A comparison of the accuracy of several techniques recently developed for solving stiff differential equations is presented. The techniques examined include two general purpose codes EEPISODE and LSODE developed for an arbitrary system of ordinary differential equations, and three specialized codes CHEMEQ, CREKID, and GCKP84 developed specifically to solve chemical kinetic rate equations. The accuracy comparisons are made by applying these solution procedures to two practical combustion kinetics problems. Both problems describe adiabatic, homogeneous, gas phase chemical reactions at constant pressure, and include all three combustion regimes: induction heat release, and equilibration. The comparisons show that LSODE is the most efficient code - in the sense that it requires the least computational work to attain a specified accuracy level. An important finding is that an iterative solution of the algebraic enthalpy conservation equation for the temperature can be more accurate and efficient than computing the temperature by integrating its time derivative.

  15. Techniques and equipment for assessing the structural integrity of subterranean tower anchor rods

    DOEpatents

    Hinz, William R.; Parker, Matthew J.

    2001-01-01

    Techniques and equipment for evaluating structural integrity of buried anchor rods in situ are disclosed. The techniques avoid excavation of soil and avoid, or at least reduce, the possibility of damage to the rods or the concrete in which they may be embedded when evaluations are conducted. Instead, ultrasonic energy is transmitted through the rod from a portable transducer, and returned energy (in either or both of direct and mode-converted states) may be analyzed to assist in detecting flaws, corrosion, wastage, or other degradation of the rod. Data from a field evaluation may be compared with baseline data maintained either for a specific rod or for rods of similar composition and length (or both), and periodic field evaluations of a rod may be used to analyze trends in its structure over time.

  16. Simulation of guided waves in complex piping geometries using the elastodynamic finite integration technique.

    PubMed

    Rudd, Kevin E; Leonard, Kevin R; Bingham, Jill P; Hinders, Mark K

    2007-03-01

    Although many technologies exist for inspecting piping systems, they are most successful on straight pipes and are often unable to accommodate the added complexities of pipe elbows, bends, twists, and branches, particularly if the region of interest is inaccessible. This paper presents a numerical technique based on the elastodynamic finite integration technique for simulating guided elastic wave propagation in piping systems. Comparisons show agreement between experimental and simulated data, and guided wave interaction with flaws, focusing, and propagation in pipe bends are presented. These examples demonstrate the ability of the simulation method to be used to study elastic wave propagation in piping systems which include three-dimensional pipe bends, and suggest its potential as a design tool for designing pipe inspection hardware and ultrasonic signal processing algorithms.

  17. Numerical modeling of elastic waves in inhomogeneous anisotropic media using 3D-elastodynamic finite integration technique

    NASA Astrophysics Data System (ADS)

    Chinta, Prashanth K.; Mayer, K.; Langenberg, K. J.

    2012-05-01

    Nondestructive Evaluation (NDE) of elastic anisotropic media is very complex because of directional dependency of elastic stiffness tensor. Modeling of elastic waves in such materials gives us intuitive knowledge about the propagation and scattering phenomena. The wave propagation in three dimensional space in anisotropic media gives us the deep insight of the transition of the different elastic wave modes i.e. mode conversion, and scattering of these waves because of inhomogeneities present in the material. The numerical tool Three Dimensional-Elastodynamic Finite Integration Technique (3D-EFIT) has been proved to be a very efficient tool for the modeling of elastic waves in very complex geometries. The 3D-EFIT is validated using the analytical approach based on the Radon transform. The simulation results of 3D-EFIT applied to inhomogeneous austenitic steel welds and wood structures are presented. In the first application the geometry consists of an austenitic steel weld that joins two isotropic steel blocks. The vertical transversal isotropic (VTI) austenitic steel is used. The convolutional perfectly matched layers are applied at the boundaries that are supported by isotropic steel. In the second application the wave propagation in the orthotropic wooden structure with an air cavity inside is investigated. The wave propagation results are illustrated using time domain elastic wave snapshots.

  18. Application of Transformational Leadership Principles in the Development and Integration of Palliative Care Within an Advanced Heart Failure Program.

    PubMed

    George, Susan; Leasure, A Renee

    2016-01-01

    Heart failure (HF) is a major health problem in United States, and it has reached epidemic proportions. Heart failure is associated with significant morbidity, mortality, and cost. Although the prognosis of HF is worse than many forms of cancer, many patients, families, and clinicians are unaware of the dire prognosis. As the disease progress to advanced HF, patients are faced with many challenges, such as poor quality of life due to worsening symptoms and frequent hospitalizations. Heart failure management adds significant financial burden to the health care system. Palliative care can be integrated into HF care to improve quality of life and symptom management and to address physical, spiritual, and psychosocial needs of patients and families. Palliative care can be used concurrently with or independent of curative or life-prolonging HF therapies. Transformational leadership principles were used to guide the development of a plan to enhance integration of palliative care within traditional advanced HF care. PMID:26836596

  19. Application of Transformational Leadership Principles in the Development and Integration of Palliative Care Within an Advanced Heart Failure Program.

    PubMed

    George, Susan; Leasure, A Renee

    2016-01-01

    Heart failure (HF) is a major health problem in United States, and it has reached epidemic proportions. Heart failure is associated with significant morbidity, mortality, and cost. Although the prognosis of HF is worse than many forms of cancer, many patients, families, and clinicians are unaware of the dire prognosis. As the disease progress to advanced HF, patients are faced with many challenges, such as poor quality of life due to worsening symptoms and frequent hospitalizations. Heart failure management adds significant financial burden to the health care system. Palliative care can be integrated into HF care to improve quality of life and symptom management and to address physical, spiritual, and psychosocial needs of patients and families. Palliative care can be used concurrently with or independent of curative or life-prolonging HF therapies. Transformational leadership principles were used to guide the development of a plan to enhance integration of palliative care within traditional advanced HF care.

  20. Integrated approach to model decomposed flow hydrograph using artificial neural network and conceptual techniques

    NASA Astrophysics Data System (ADS)

    Jain, Ashu; Srinivasulu, Sanaga

    2006-02-01

    This paper presents the findings of a study aimed at decomposing a flow hydrograph into different segments based on physical concepts in a catchment, and modelling different segments using different technique viz. conceptual and artificial neural networks (ANNs). An integrated modelling framework is proposed capable of modelling infiltration, base flow, evapotranspiration, soil moisture accounting, and certain segments of the decomposed flow hydrograph using conceptual techniques and the complex, non-linear, and dynamic rainfall-runoff process using ANN technique. Specifically, five different multi-layer perceptron (MLP) and two self-organizing map (SOM) models have been developed. The rainfall and streamflow data derived from the Kentucky River catchment were employed to test the proposed methodology and develop all the models. The performance of all the models was evaluated using seven different standard statistical measures. The results obtained in this study indicate that (a) the rainfall-runoff relationship in a large catchment consists of at least three or four different mappings corresponding to different dynamics of the underlying physical processes, (b) an integrated approach that models the different segments of the decomposed flow hydrograph using different techniques is better than a single ANN in modelling the complex, dynamic, non-linear, and fragmented rainfall runoff process, (c) a simple model based on the concept of flow recession is better than an ANN to model the falling limb of a flow hydrograph, and (d) decomposing a flow hydrograph into the different segments corresponding to the different dynamics based on the physical concepts is better than using the soft decomposition employed using SOM.

  1. Image accuracy and representational enhancement through low-level, multi-sensor integration techniques

    SciTech Connect

    Baker, J.E.

    1994-09-01

    Multi-Sensor Integration (MSI) is the combining of data and information from more than one source in order to generate a more reliable and consistent representation of the environment. The need for MSI derives largely from basic ambiguities inherent in our current sensor imaging technologies. These ambiguities exist as long as the mapping from reality to image is not 1-to-1. That is, if different {open_quotes}realities{close_quotes} lead to identical images, a single image cannot reveal the particular reality which was the truth. MSI techniques attempt to resolve some of these ambiguities by appropriately coupling complementary images to eliminate possible inverse mappings. What constitutes the best MSI technique is dependent on the given application domain, available sensors, and task requirements. MSI techniques can be divided into three categories based on the relative information content of the original images with that of the desired representation: (1) {open_quotes}detail enhancement,{close_quotes} wherein the relative information content of the original images is less rich than the desired representation; (2) {open_quotes}data enhancement,{close_quotes} wherein the MSI techniques are concerned with improving the accuracy of the data rather than either increasing or decreasing the level of detail; and (3) {open_quotes}conceptual enhancement,{close_quotes} wherein the image contains more detail than is desired, making it difficult to easily recognize objects of interest. In conceptual enhancement one must group pixels corresponding to the same conceptual object and thereby reduce the level of extraneous detail.

  2. Evaluation of an adaptive unstructured remeshing technique for integrated fluid-thermal-structural analysis

    NASA Technical Reports Server (NTRS)

    Dechaumphai, Pramote

    1990-01-01

    An adaptive unstructured remeshing technique is evaluated for integrated fluid-thermal-structural analysis. The technique is combined with the finite element method to solve: (1) the Navier-Stokes equations for high-speed compressible flow; (2) the energy equation for the structural-thermal response; and (3) the quasi-static equilibrium equations for the structural response. The remeshing technique and the analysis solution procedure are described. The effectiveness of the approach is evaluated with two application studies. The flow analysis of Mach 8 shock-shock interference on a three-inch-diameter cylinder is used as the first application study to demonstrate the capability of the remeshing technique and to examine proper remeshing indicators for the inviscid and boundary layer regions. The applicability of the approach for the thermal and structural analyses of the structure is evaluated in the second application study of a 0.25-inch-diameter convectively cooled leading edge subjected to intense aerodynamic heating. Issues associated with remeshing indicators for thermal stress problems are identified.

  3. Fourier transform of the multicenter product of 1s hydrogenic orbitals and Coulomb or Yukawa potentials and the analytically reduced form for subsequent integrals that include plane waves

    NASA Technical Reports Server (NTRS)

    Straton, Jack C.

    1989-01-01

    The Fourier transform of the multicenter product of N 1s hydrogenic orbitals and M Coulomb or Yukawa potentials is given as an (M+N-1)-dimensional Feynman integral with external momenta and shifted coordinates. This is accomplished through the introduction of an integral transformation, in addition to the standard Feynman transformation for the denominators of the momentum representation of the terms in the product, which moves the resulting denominator into an exponential. This allows the angular dependence of the denominator to be combined with the angular dependence in the plane waves.

  4. PwrSoC (integration of micro-magnetic inductors/transformers with active semiconductors) for more than Moore technologies

    NASA Astrophysics Data System (ADS)

    Mathuna, Cian Ó.; Wang, Ningning; Kulkarni, Santosh; Roy, Saibal

    2013-07-01

    This paper introduces the concept of power supply on chip (PwrSoC) which will enable the development of next-generation, functionally integrated, power management platforms with applications in dc-dc conversion, gate drives, isolated power transmission and ultimately, high granularity, on-chip, power management for mixed-signal, SOC chips. PwrSoC will integrate power passives with the power management IC, in a 3D stacked or monolithic form factor, thereby delivering the performance of a highefficiency dc-dc converter within the footprint of a low-efficiency linear regulator. A central element of the PwrSoC concept is the fabrication of power micro-magnetics on silicon to deliver micro-inductors and micro-transformers. The paper details the magnetics on silicon process which combines thin film magnetic core technology with electroplated copper conductors. Measured data for micro-inductors show inductance operation up to 20 MHz, footprints down to 0.5 mm2, efficiencies up to 93% and dc current carrying capability up to 600 mA. Measurements on micro-transformers show voltage gain of approximately - 1 dB at between 10 MHz and 30 MHz. Contribution to the Topical Issue “International Semiconductor Conference Dresden-Grenoble - ISCDG 2012”, Edited by Gérard Ghibaudo, Francis Balestra and Simon Deleonibus.

  5. Expression and genomic integration of transgenes after Agrobacterium-mediated transformation of mature barley embryos.

    PubMed

    Uçarlı, C; Tufan, F; Gürel, F

    2015-01-01

    Mature embryos in tissue cultures are advantageous because of their abundance and rapid germination, which reduces genomic instability problems. In this study, 2-day-old isolated mature barley embryos were infected with 2 Agrobacterium hypervirulent strains (AGL1 and EHA105), followed by a 3-day period of co-cultivation in the presence of L-cystein amino acid. Chimeric expression of the b-glucuronidase gene (gusA) directed by a viral promoter of strawberry vein banding virus was observed in coleoptile epidermal cells and seminal roots in 5-day-old germinated seedlings. In addition to varying infectivity patterns in different strains, there was a higher ratio of transient b-glucuronidase expression in developing coleoptiles than in embryonic roots, indicating the high competency of shoot apical meristem cells in the mature embryo. A total of 548 explants were transformed and 156 plants developed to maturity on G418 media after 18-25 days. We detected transgenes in 74% of the screened plant leaves by polymerase chain reaction, and 49% of these expressed neomycin phosphotransferase II gene following AGL1 transformation. Ten randomly selected T0 transformants were analyzed using thermal asymmetric interlaced polymerase chain reaction and 24 fragments ranged between 200-600 base pairs were sequenced. Three of the sequences flanked with transferred-DNA showed high similarity to coding regions of the barley genome, including alpha tubulin5, homeobox 1, and mitochondrial 16S genes. We observed 70-200-base pair filler sequences only in the coding regions of barley in this study. PMID:25730049

  6. Expression and genomic integration of transgenes after Agrobacterium-mediated transformation of mature barley embryos.

    PubMed

    Uçarlı, C; Tufan, F; Gürel, F

    2015-02-06

    Mature embryos in tissue cultures are advantageous because of their abundance and rapid germination, which reduces genomic instability problems. In this study, 2-day-old isolated mature barley embryos were infected with 2 Agrobacterium hypervirulent strains (AGL1 and EHA105), followed by a 3-day period of co-cultivation in the presence of L-cystein amino acid. Chimeric expression of the b-glucuronidase gene (gusA) directed by a viral promoter of strawberry vein banding virus was observed in coleoptile epidermal cells and seminal roots in 5-day-old germinated seedlings. In addition to varying infectivity patterns in different strains, there was a higher ratio of transient b-glucuronidase expression in developing coleoptiles than in embryonic roots, indicating the high competency of shoot apical meristem cells in the mature embryo. A total of 548 explants were transformed and 156 plants developed to maturity on G418 media after 18-25 days. We detected transgenes in 74% of the screened plant leaves by polymerase chain reaction, and 49% of these expressed neomycin phosphotransferase II gene following AGL1 transformation. Ten randomly selected T0 transformants were analyzed using thermal asymmetric interlaced polymerase chain reaction and 24 fragments ranged between 200-600 base pairs were sequenced. Three of the sequences flanked with transferred-DNA showed high similarity to coding regions of the barley genome, including alpha tubulin5, homeobox 1, and mitochondrial 16S genes. We observed 70-200-base pair filler sequences only in the coding regions of barley in this study.

  7. Integration of ab-initio nuclear calculation with derivative free optimization technique

    SciTech Connect

    Sharda, Anurag

    2008-01-01

    Optimization techniques are finding their inroads into the field of nuclear physics calculations where the objective functions are very complex and computationally intensive. A vast space of parameters needs searching to obtain a good match between theoretical (computed) and experimental observables, such as energy levels and spectra. Manual calculation defies the scope of such complex calculation and are prone to error at the same time. This body of work attempts to formulate a design and implement it which would integrate the ab initio nuclear physics code MFDn and the VTDIRECT95 code. VTDIRECT95 is a Fortran95 suite of parallel code implementing the derivative-free optimization algorithm DIRECT. Proposed design is implemented for a serial and parallel version of the optimization technique. Experiment with the initial implementation of the design showing good matches for several single-nucleus cases are conducted. Determination and assignment of appropriate number of processors for parallel integration code is implemented to increase the efficiency and resource utilization in the case of multiple nuclei parameter search.

  8. Inverse measurement of stiffness by the normalization technique for J-integral fracture toughness

    SciTech Connect

    Brown, Eric

    2012-06-07

    The single specimen normalization technique for J-integral fracture toughness has been successfully employed by several researchers to study the strongly non-linear fracture response of ductile semicrystalline polymers. As part of the normalization technique the load and the plastic component of displacement are normalized. The normalized data is then fit with a normalization function that approximates a power law for small displacements that are dominated by blunting and smoothly transitions to a linear relationship for large displacements that are dominated by stable crack extension. Particularly for very ductile polymers the compliance term used to determine the plastic displacement can dominate the solution and small errors in determining the elastic modulus can lead to large errors in the normalization or even make it ill-posed. This can be further complicated for polymers where the elastic modulus is strong strain rate dependent and simply using a 'quasistatic' modulus from a dogbone measurement may not equate to the dominant strain rate in the compact tension specimen. The current work proposes directly measuring the compliance of the compact tension specimen in the solution of J-integral fracture toughness and then solving for the elastic modulus. By comparison with a range of strain rate data the dominant strain rate can then be determined.

  9. Integration of datasets from different analytical techniques to assess the impact of nutrition on human metabolome

    PubMed Central

    Vernocchi, Pamela; Vannini, Lucia; Gottardi, Davide; Del Chierico, Federica; Serrazanetti, Diana I.; Ndagijimana, Maurice; Guerzoni, Maria E.

    2012-01-01

    Bacteria colonizing the human intestinal tract exhibit a high phylogenetic diversity that reflects their immense metabolic potentials. The catalytic activity of gut microbes has an important impact on gastrointestinal (GI) functions and host health. The microbial conversion of carbohydrates and other food components leads to the formation of a large number of compounds that affect the host metabolome and have beneficial or adverse effects on human health. Metabolomics is a metabolic-biology system approach focused on the metabolic responses understanding of living systems to physio-pathological stimuli by using multivariate statistical data on human body fluids obtained by different instrumental techniques. A metabolomic approach based on an analytical platform could be able to separate, detect, characterize and quantify a wide range of metabolites and its metabolic pathways. This approach has been recently applied to study the metabolic changes triggered in the gut microbiota by specific diet components and diet variations, specific diseases, probiotic and synbiotic food intake. This review describes the metabolomic data obtained by analyzing human fluids by using different techniques and particularly Gas Chromatography Mass Spectrometry Solid-phase Micro Extraction (GC-MS/SPME), Proton Nuclear Magnetic Resonance (1H-NMR) Spectroscopy and Fourier Transform Infrared (FTIR) Spectroscopy. This instrumental approach has a good potential in the identification and detection of specific food intake and diseases biomarkers. PMID:23248777

  10. Spectral Characterizations of the Clouds and the Earth's Radiant Energy System (CERES) Thermistor Bolometers using Fourier Transform Spectrometer (FTS) Techniques

    NASA Technical Reports Server (NTRS)

    Thornhill, K. Lee; Bitting, Herbert; Lee, Robert B., III; Paden, Jack; Pandey, Dhirendra K.; Priestley, Kory J.; Thomas, Susan; Wilson, Robert S.

    1998-01-01

    Fourier Transform Spectrometer (FTS) techniques are being used to characterize the relative spectral response, or sensitivity, of scanning thermistor bolometers in the infrared (IR) region (2 - >= 100-micrometers). The bolometers are being used in the Clouds and the Earth's Radiant Energy System (CERES) program. The CERES measurements are designed to provide precise, long term monitoring of the Earth's atmospheric radiation energy budget. The CERES instrument houses three bolometric radiometers, a total wavelength (0.3- >= 150-micrometers) sensor, a shortwave (0.3-5-micrometers) sensor, and an atmospheric window (8-12-micrometers) sensor. Accurate spectral characterization is necessary for determining filtered radiances for longwave radiometric calibrations. The CERES bolometers spectral response's are measured in the TRW FTS Vacuum Chamber Facility (FTS - VCF), which uses a FTS as the source and a cavity pyroelectric trap detector as the reference. The CERES bolometers and the cavity detector are contained in a vacuum chamber, while the FTS source is housed in a GN2 purged chamber. Due to the thermal time constant of the CERES bolometers, the FTS must be operated in a step mode. Data are acquired in 6 IR spectral bands covering the entire longwave IR region. In this paper, the TRW spectral calibration facility design and data measurement techniques are described. Two approaches are presented which convert the total channel FTS data into the final CERES spectral characterizations, producing the same calibration coefficients (within 0.1 percent). The resulting spectral response curves are shown, along with error sources in the two procedures. Finally, the impact of each spectral response curve on CERES data validation will be examined through analysis of filtered radiance values from various typical scene types.

  11. Measuring Temperature-Dependent Propagating Disturbances in Coronal Fan Loops Using Multiple SDO-AIA Channels and Surfing Transform Technique

    NASA Technical Reports Server (NTRS)

    Uritskiy, Vadim M.; Davila, Joseph M.; Viall, Nicholeen M.; Ofman, Leon

    2013-01-01

    A set of co-aligned high resolution images from the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO) is used to investigate propagating disturbances (PDs) in warm fan loops at the periphery of a non-flaring active region NOAA AR 11082. To measure PD speeds at multiple coronal temperatures, a new data analysis methodology is proposed enabling quantitative description of sub visual coronal motions with low signal-to-noise ratios of the order of 0.1. The technique operates with a set of one-dimensional surfing signals extracted from position-timeplots of several AIA channels through a modified version of Radon transform. The signals are used to evaluate a two-dimensional power spectral density distribution in the frequency - velocity space which exhibits a resonance in the presence of quasi-periodic PDs. By applying this analysis to the same fan loop structures observed in several AIA channels, we found that the traveling velocity of PDs increases with the temperature of the coronal plasma following the square root dependence predicted for the slow mode magneto-acoustic wave which seems to be the dominating wave mode in the studied loop structures. This result extends recent observations by Kiddie et al. (2012) to a more general class of fan loop systems not associated with sunspots and demonstrating consistent slow mode activity in up to four AIA channels.

  12. Integration of various subsurface exploration techniques to solve problems at sites contaminated with petroleum hydrocarbons

    SciTech Connect

    Hickey, J.C.; Hatheway, M.H.

    1996-12-31

    As a result of both regulatory and property transfer driven investigations of petroleum distribution and storage sites, countless contamination issues have been identified. Thoughtful selection and use of different geochemical, geologic, and geophysical subsurface exploration techniques can significantly increase the cost effectiveness of investigation, remedial design/implementation, and post-closure monitoring programs. Three case histories highlighting the approach are presented. In each case, careful consideration of data needs, methods capabilities and limitations resulted in the sequenced integration of specific investigatory tools to generate the required information. These are: (1) First discussed will be the use of ground penetrating radar, seismic refraction, active and passive soil vapor surveys, installation of monitoring wells, and use of lineament/fracture trace analysis to guide the remedial investigation and system design meant to evaluate and correct gasoline and diesel releases at a major highway truck stop. (2) The use of a passive soil vapor survey, grab soil and groundwater sampling, and traditional monitoring well program at a former retail gasoline distribution site in Colorado will be presented next. Data generated by this integrated investigation were used in support of a risk assessment and remediation system design. (3) Lastly, the use of an active soil vapor survey, grab sampling and field analyses and integration with results from previous remedial investigations and emergency response measures at a commercial truck leasing facility will be overviewed. The results identified areas of residual soil contamination not addressed during the emergency response measures.

  13. Integration of various subsurface exploration techniques to solve problems at sites contaminated with petroleum hydrocarbons

    SciTech Connect

    Hickey, J.C.; Hatheway, M.H. ); Tingley, A.C. )

    1996-01-01

    As a result of both regulatory and property transfer driven investigations of petroleum distribution and storage sites, countless contamination issues have been identified. Thoughtful selection and use of different geochemical, geologic, and geophysical subsurface exploration techniques can significantly increase the cost effectiveness of investigation, remedial design/implementation, and post-closure monitoring programs. Three case histories highlighting the approach are presented. In each case, careful consideration of data needs, methods capabilities and limitations resulted in the sequenced integration of specific investigatory tools to generate the required information. These are: (1) First discussed will be the use of ground penetrating radar, seismic refraction, active and passive soil vapor surveys, installation of monitoring wells, and use of lineament/fracture trace analysis to guide the remedial investigation and system design meant to evaluate and correct gasoline and diesel releases at a major highway truck stop. (2) The use of a passive soil vapor survey, grab soil and groundwater sampling, and traditional monitoring well program at a former retail gasoline distribution site in Colorado will be presented next. Data generated by this integrated investigation were used in support of a risk assessment and remediation system design. (3) Lastly, the use of an active soil vapor survey, grab sampling and field analyses and integration with results from previous remedial investigations and emergency response measures at a commercial truck leasing facility will be overviewed. The results identified areas of residual soil contamination not addressed during the emergency response measures.

  14. Transforming Education into the 21st Century by Integrating 1:1 iPads

    ERIC Educational Resources Information Center

    Belcher, Kermit E.

    2014-01-01

    Teachers at Mason County High School are changing from predominantly teacher led instruction to increased student engagement by providing blended learning opportunities through technology integration. Every student and teacher at Mason County High School was provided an iPad as a resource to enhance instruction. The purpose of this case study is…

  15. Revenue Forecasting to Integrate CCC Planning and Resource Allocation for Transformative Leadership

    ERIC Educational Resources Information Center

    Hovey, Ann

    2012-01-01

    In recent years the majority of California community colleges evaluated for re-accreditation received sanctions requiring documented improvement in the integration of college planning and budgeting processes. This study explores the challenges colleges face and the best practices utilized by successful colleges in implementing integrated…

  16. New plasma technique for the deposition of silica layers for integrated optics applications

    NASA Astrophysics Data System (ADS)

    Panciatichi, Cristina; Natascia De Leo, Maria C.

    2000-03-01

    An inductively coupled plasma torch has been used for the synthesis of high-purity, low OH concentration, fused silica layers, for integrated optics applications. This technique is very versatile and the same apparatus can be used to deposit silica layers doped with different elements but this work is particularly devoted to the germanium-doped silica layers. The torch, designed and built in-house, operates at atmospheric pressure and is posed by a 13.56 MHz, 5.4 kW, RF generator. The gaseous reactants are injected in the plasma tail flame by a silica nozzle. Planar silica targets are suitably moved over the torch exit in order to obtain the desired deposition. The samples made by means of this chemical vapor deposition process have been chemically and physically analyzed using various techniques: optical microscopy, scanning electron microscopy, atomic force microscopy, x-ray diffractometer, UV, visible and IR spectroscopy, to test their morphological, geometrical, chemical and optical characteristics. By this plasma- assisted technique it has been possible to achieve the deposition of pure and germanium doped silica layers with good optical and morphological characteristics. Preliminary direct UV photoinduction experiments are very promising: a high refractive index change has been measured.

  17. Extract transformation loading from OLTP to OLAP data using pentaho data integration

    NASA Astrophysics Data System (ADS)

    Salaki, R. J.; Waworuntu, J.; Tangkawarow, I. R. H. T.

    2016-04-01

    The design of the data warehouse in this case is expected to solve the problem of evaluation of learning results as well as the relevance of the information received to support decision-making by the leader. Data warehouse design is very important, which is designed to utilize the existing resources of information. GPA (Grade Point Average) data warehouse can be used for the process of evaluation, decision making and even further planning of the study program of PTIK. The diversity of data sources in the course PTIK make decisionmaking and evaluation process becomes not easier. Pentaho Data Integration is used to integrate data in PTIK easy. CPI data warehouse design with multidimensional database modeling approach using the dimension tables and fact tables.

  18. InTeGrate: Transforming the Teaching of Geoscience and Sustainability

    NASA Astrophysics Data System (ADS)

    Blockstein, D.; Manduca, C. A.; Bralower, T. J.; Castendyk, D.; Egger, A. E.; Gosselin, D. C.; Iverson, E. A.; Matson, P. A.; MacGregor, J.; Mcconnell, D. A.; Mogk, D. W.; Nevle, R. J.; Oches, E. A.; Steer, D. N.; Wiese, K.

    2012-12-01

    InTeGrate is an NSF-funded community project to improve geoscience literacy and build a workforce that can apply geoscience principles to address societal issues. Three workshops offered this year by InTeGrate and its partner, On the Cutting Edge, addressed strategies for bringing together geoscience and sustainability within geoscience courses and programs, in interdisciplinary courses and programs, and in courses and programs in other disciplines or schools including arts and humanities, health science, and business. Participants in all workshops described the power of teaching geoscience in the context of sustainability and the utility of this approach in engaging students with geoscience, including student populations not traditionally represented in the sciences. Faculty involved in both courses and programs seek to teach important skills including the ability to think about systems and to make connections between local observations and challenges and global phenomena and issues. Better articulation of these skills, including learning outcomes and assessments, as well as documenting the relationship between these skills and employment opportunities were identified as important areas for further work. To support widespread integration of geoscience and sustainability concepts, these workshops initiated collections describing current teaching activities, courses, and programs. InTeGrate will continue to build these collections in collaboration with On the Cutting Edge and Building Strong Geoscience Departments, and through open contributions by individual faculty and programs. In addition, InTeGrate began developing new teaching modules and courses. Materials for use in introductory geoscience and environmental science/studies courses, distance learning courses, and courses for education majors are being developed and tested by teams of faculty drawn from at least three institutions, including several members from two-year colleges. An assessment team is

  19. Use of time history speckle pattern and pulsed photoacoustic techniques to detect the self-accommodating transformation in a Cu-Al-Ni shape memory alloy

    SciTech Connect

    Sanchez-Arevalo, F.M.; Aldama-Reyna, W.; Lara-Rodriguez, A.G.; Garcia-Fernandez, T.; Pulos, G.; Trivi, M.; Villagran-Muniz, M.

    2010-05-15

    Continuous and pulsed electromagnetic radiation was used to detect the self-accommodation mechanism on a polycrystalline Cu-13.83 wt.%Al-2.34 wt.%Ni shape memory alloy. Rectangular samples of this alloy were mechanically polished to observe the austenite and martensite phases. The samples were cooled in liquid nitrogen prior to the experiments to obtain the martensite phase. Using a dynamic speckle technique with a continuous wave laser we obtained the time history of the speckle pattern image and monitored the surface changes caused by the self-accommodation mechanism during the inverse (martensitic to austenitic) transformation. Using a photoacoustic technique based on a pulsed laser source it was also possible to detect the self-accommodation phenomena in a bulk sample. For comparison purposes, we used differential scanning calorimetry (DSC) to detect the critical temperatures of transformation and use these as reference to evaluate the performance of the optical and photoacoustical techniques. In all cases, the same range of temperature was obtained during the inverse transformation. From these results, we conclude that time history speckle pattern (THSP) and pulsed photoacoustic are complementary techniques; they are non-destructive and useful to detect surface and bulk martensitic transformation induced by a temperature change.

  20. A new approach of weighted integration technique based on accumulated images using dynamic PET and H2(15)O

    SciTech Connect

    Yokoi, T.; Kanno, I.; Iida, H.; Miura, S.; Uemura, K. )

    1991-05-01

    We developed a new technique of weighted integration for the measurement of local cerebral blood flow (LCBF) and the blood-tissue partition coefficient (p) using dynamic positron emission tomography (PET) and H2(15)O. The weighted integration in the new technique is carried out on the equation of the first time integration of the Kety-Schmidt differential equation. Practically, serially accumulated images with sequentially prolonged accumulation times are weighted by two arbitrary functions. The weighting functions do not have to be differentiated because of the exclusion of the differential term in the starting equation. Consequently, the method does not require data at the end of the scan. The technique was applied to H2(15)O dynamic PET performed on four normal subjects, and was verified to provide a better signal-to-noise ratio than the previously developed integrated projection (IP) technique. Computer simulations were carried out to investigate the effects of statistical noise, tissue heterogeneity, and time delay and dispersion in arterial input function. The simulation showed that the new technique provided about a 1.4 times lower statistical error in both LCBF and p at 50 ml 100 g-1 min-1 compared to the IP technique, and it should be noted that the new technique was less sensitive to the shape of the weighting functions. The new technique provides a new strategy with respect to the statistical error for estimation of LCBF and p.

  1. Triple transformation

    NASA Astrophysics Data System (ADS)

    Khan, Farrukh I.; Schinn, Dustin S.

    2013-08-01

    A new business plan that enables policy transformation and resource mobilization at the national and international level, while improving access to resources, will allow the Green Climate Fund to integrate development goals and action on climate change.

  2. The derivation of vector magnetic fields from Stokes profiles - Integral versus least squares fitting techniques

    NASA Technical Reports Server (NTRS)

    Ronan, R. S.; Mickey, D. L.; Orrall, F. Q.

    1987-01-01

    The results of two methods for deriving photospheric vector magnetic fields from the Zeeman effect, as observed in the Fe I line at 6302.5 A at high spectral resolution (45 mA), are compared. The first method does not take magnetooptical effects into account, but determines the vector magnetic field from the integral properties of the Stokes profiles. The second method is an iterative least-squares fitting technique which fits the observed Stokes profiles to the profiles predicted by the Unno-Rachkovsky solution to the radiative transfer equation. For sunspot fields above about 1500 gauss, the two methods are found to agree in derived azimuthal and inclination angles to within about + or - 20 deg.

  3. Integrated State Estimation and Contingency Analysis Software Implementation using High Performance Computing Techniques

    SciTech Connect

    Chen, Yousu; Glaesemann, Kurt R.; Rice, Mark J.; Huang, Zhenyu

    2015-12-31

    Power system simulation tools are traditionally developed in sequential mode and codes are optimized for single core computing only. However, the increasing complexity in the power grid models requires more intensive computation. The traditional simulation tools will soon not be able to meet the grid operation requirements. Therefore, power system simulation tools need to evolve accordingly to provide faster and better results for grid operations. This paper presents an integrated state estimation and contingency analysis software implementation using high performance computing techniques. The software is able to solve large size state estimation problems within one second and achieve a near-linear speedup of 9,800 with 10,000 cores for contingency analysis application. The performance evaluation is presented to show its effectiveness.

  4. The use of hypnotic age progressions as prognostic, ego-strengthening, and integrating techniques.

    PubMed

    Phillips, M; Frederick, C

    1992-10-01

    Age progression as a hypnotherapeutic technique is mentioned infrequently in the literature when compared with its counterpart, age regression. In this paper we explore the use of progressions, or "views of the future," as prognostic indicators of therapeutic progress and as valuable tools for ego strengthening and for the integration of clinical material. Age progressions vary in the types of suggestions given and can be used to promote growth on multiple levels, facilitating treatment goals and deepening the working-through process. We present six cases in which we used different types of age progressions, and we discuss the significance of the progressions used in each case, within the context of relevant clinical material. We conclude from our observations that the use of hypnotic progressions can be a sustaining, valuable aspect of hypnotherapy, particularly in providing an index of the current direction and progression of the therapy process itself.

  5. Integrating advanced materials simulation techniques into an automated data analysis workflow at the Spallation Neutron Source

    SciTech Connect

    Borreguero Calvo, Jose M; Campbell, Stuart I; Delaire, Olivier A; Doucet, Mathieu; Goswami, Monojoy; Hagen, Mark E; Lynch, Vickie E; Proffen, Thomas E; Ren, Shelly; Savici, Andrei T; Sumpter, Bobby G

    2014-01-01

    This presentation will review developments on the integration of advanced modeling and simulation techniques into the analysis step of experimental data obtained at the Spallation Neutron Source. A workflow framework for the purpose of refining molecular mechanics force-fields against quasi-elastic neutron scattering data is presented. The workflow combines software components to submit model simulations to remote high performance computers, a message broker interface for communications between the optimizer engine and the simulation production step, and tools to convolve the simulated data with the experimental resolution. A test application shows the correction to a popular fixed-charge water model in order to account polarization effects due to the presence of solvated ions. Future enhancements to the refinement workflow are discussed. This work is funded through the DOE Center for Accelerating Materials Modeling.

  6. Dimension reduction techniques for the integrative analysis of multi-omics data

    PubMed Central

    Zeleznik, Oana A.; Thallinger, Gerhard G.; Kuster, Bernhard; Gholami, Amin M.

    2016-01-01

    State-of-the-art next-generation sequencing, transcriptomics, proteomics and other high-throughput ‘omics' technologies enable the efficient generation of large experimental data sets. These data may yield unprecedented knowledge about molecular pathways in cells and their role in disease. Dimension reduction approaches have been widely used in exploratory analysis of single omics data sets. This review will focus on dimension reduction approaches for simultaneous exploratory analyses of multiple data sets. These methods extract the linear relationships that best explain the correlated structure across data sets, the variability both within and between variables (or observations) and may highlight data issues such as batch effects or outliers. We explore dimension reduction techniques as one of the emerging approaches for data integration, and how these can be applied to increase our understanding of biological systems in normal physiological function and disease. PMID:26969681

  7. Future Directions in Pain Management: Integrating Anatomically Selective Delivery Techniques With Novel Molecularly Selective Agents.

    PubMed

    Pleticha, Josef; Maus, Timothy P; Beutler, Andreas S

    2016-04-01

    Treatment for chronic, locoregional pain ranks among the most prevalent unmet medical needs. The failure of systemic analgesic drugs, such as opioids, is often due to their off-target toxicity, development of tolerance, and abuse potential. Interventional pain procedures provide target specificity but lack pharmacologically selective agents with long-term efficacy. Gene therapy vectors are a new tool for the development of molecularly selective pain therapies, which have already been proved to provide durable analgesia in preclinical models. Taken together, advances in image-guided delivery and gene therapy may lead to a new class of dual selective analgesic treatments integrating the molecular selectivity of analgesic genes with the anatomic selectivity of interventional delivery techniques.

  8. Dimension reduction techniques for the integrative analysis of multi-omics data.

    PubMed

    Meng, Chen; Zeleznik, Oana A; Thallinger, Gerhard G; Kuster, Bernhard; Gholami, Amin M; Culhane, Aedín C

    2016-07-01

    State-of-the-art next-generation sequencing, transcriptomics, proteomics and other high-throughput 'omics' technologies enable the efficient generation of large experimental data sets. These data may yield unprecedented knowledge about molecular pathways in cells and their role in disease. Dimension reduction approaches have been widely used in exploratory analysis of single omics data sets. This review will focus on dimension reduction approaches for simultaneous exploratory analyses of multiple data sets. These methods extract the linear relationships that best explain the correlated structure across data sets, the variability both within and between variables (or observations) and may highlight data issues such as batch effects or outliers. We explore dimension reduction techniques as one of the emerging approaches for data integration, and how these can be applied to increase our understanding of biological systems in normal physiological function and disease.

  9. Deletions in the Gibberellin Biosynthesis Gene Cluster of Gibberella fujikuroi by Restriction Enzyme-Mediated Integration and Conventional Transformation-Mediated Mutagenesis

    PubMed Central

    Linnemannstöns, Pia; Voß, Thorsten; Hedden, Peter; Gaskin, Paul; Tudzynski, Bettina

    1999-01-01

    We induced mutants of Gibberella fujikuroi deficient in gibberellin (GA) biosynthesis by transformation-mediated mutagenesis with the vector pAN7-1. We recovered 24 GA-defective mutants in one of nine transformation experiments performed without the addition of a restriction enzyme. Each mutant had a similar Southern blot pattern, suggesting the integration of the vector into the same site. The addition of a restriction enzyme by restriction enzyme-mediated integration (REMI) significantly increased the transformation rate and the rate of single-copy integration events. Of 1,600 REMI transformants, two produced no GAs. Both mutants had multiple copies of the vector pAN7-1 and one had a Southern blot pattern similar to those of the 24 conventionally transformed GA-deficient mutants. Biochemical analysis of the two REMI mutants confirmed that they cannot produce ent-kaurene, the first specific intermediate of the GA pathway. Feeding the radioactively labelled precursors ent-kaurene and GA12-aldehyde followed by high-performance liquid chromatography and gas chromatography-mass spectrometry analysis showed that neither of these intermediates was converted to GAs in the mutants. Southern blot analysis and pulsed-field gel electrophoresis of the transformants using the bifunctional ent-copalyl diphosphate/ent-kaurene synthase gene (cps/ks) and the flanking regions as probes revealed a large deletion in the GA-deficient REMI transformants and in the GA-deficient transformants obtained by conventional insertional transformation. We conclude that transformation procedures with and without the addition of restriction enzymes can lead to insertion-mediated mutations and to deletions and chromosome translocations. PMID:10347043

  10. High-sensitivity Leak-testing Method with High-Resolution Integration Technique

    NASA Astrophysics Data System (ADS)

    Fujiyoshi, Motohiro; Nonomura, Yutaka; Senda, Hidemi

    A high-resolution leak-testing method named HR (High-Resolution) Integration Technique has been developed for MEMS (Micro Electro Mechanical Systems) sensors such as a vibrating angular-rate sensor housed in a vacuum package. Procedures of the method to obtain high leak-rate resolution were as follows. A package filled with helium gas was kept in a small accumulation chamber to accumulate helium gas leaking from the package. After the accumulation, the accumulated helium gas was introduced into a mass spectrometer in a short period of time, and the flux of the helium gas was measured by the mass spectrometer as a transient phenomenon. The leak-rate of the package was calculated from the detected transient waveform of the mass spectrometer and the accumulation time of the helium gas in the accumulation chamber. Because the density of the helium gas in the vacuum chamber increased and the accumulated helium gas was measured in a very short period of time with the mass spectrometer, the peak strength of the transient waveform became high and the signal to noise ratio was much improved. The detectable leak-rate resolution of the technique reached 1×10-15 (Pa·m3/s). This resolution is 103 times superior to that of the conventional helium vacuum integration method. The accuracy of the measuring system was verified with a standard helium gas leak source. The results were well matched between theoretical calculation based on the leak-rate of the source and the experimental results within only 2% error.

  11. Application of Energy Integration Techniques to the Design of Advanced Life Support Systems

    NASA Technical Reports Server (NTRS)

    Levri, Julie; Finn, Cory

    2000-01-01

    Exchanging heat between hot and cold streams within an advanced life support system can save energy. This savings will reduce the equivalent system mass (ESM) of the system. Different system configurations are examined under steady-state conditions for various percentages of food growth and waste treatment. The scenarios investigated represent possible design options for a Mars reference mission. Reference mission definitions are drawn from the ALSS Modeling and Analysis Reference Missions Document, which includes definitions for space station evolution, Mars landers, and a Mars base. For each scenario, streams requiring heating or cooling are identified and characterized by mass flow, supply and target temperatures and heat capacities. The Pinch Technique is applied to identify good matches for energy exchange between the hot and cold streams and to calculate the minimum external heating and cooling requirements for the system. For each pair of hot and cold streams that are matched, there will be a reduction in the amount of external heating and cooling required, and the original heating and cooling equipment will be replaced with a heat exchanger. The net cost savings can be either positive or negative for each stream pairing, and the priority for implementing each pairing can be ranked according to its potential cost savings. Using the Pinch technique, a complete system heat exchange network is developed and heat exchangers are sized to allow for calculation of ESM. The energy-integrated design typically has a lower total ESM than the original design with no energy integration. A comparison of ESM savings in each of the scenarios is made to direct future Pinch Analysis efforts.

  12. Integration of sexual trauma in a religious narrative: transformation, resolution and growth among contemplative nuns.

    PubMed

    Durà-Vilà, Glòria; Littlewood, Roland; Leavey, Gerard

    2013-02-01

    The psychological consequences of sexual abuse are generally serious and enduring, particularly when the perpetrator is known and trusted by the survivor. This paper explores the experiences of five contemplative nuns who were sexually abused by priests and the spiritual journeys that followed. In the context of an ethnographic study of contemplative practice, participant observation and in-depth interviews were used to examine the ways that the nuns sought to make sense of their experiences through a long process of solitary introspection. The pursuit of meaning was shaped by religious beliefs relating to forgiveness, sacrifice, and salvation. Thus, trauma was transformed into a symbolic religious narrative that shaped their sense of identity. They were able to restructure core beliefs and to manage their current relationships with priests more securely. They described regaining their spiritual well-being in ways that suggest a form of posttraumatic spiritual growth. We conclude by discussing the findings in the light of the existing literature on the interaction of trauma and spirituality.

  13. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions

    PubMed Central

    Zheng, Wei; Nurmi, Harri; Appak, Sila; Sabine, Amélie; Bovay, Esther; Korhonen, Emilia A.; Orsenigo, Fabrizio; Lohela, Marja; D’Amico, Gabriela; Holopainen, Tanja; Leow, Ching Ching; Dejana, Elisabetta; Petrova, Tatiana V.; Augustin, Hellmut G.; Alitalo, Kari

    2014-01-01

    Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting lymphatics during development. Lymphatic endothelial cell (LEC) junctions in initial lymphatics transform from a zipper-like to a button-like pattern during collecting vessel development, but what regulates this process is largely unknown. Angiopoietin 2 (Ang2) deficiency leads to abnormal lymphatic vessels. Here we found that an ANG2-blocking antibody inhibited embryonic lymphangiogenesis, whereas endothelium-specific ANG2 overexpression induced lymphatic hyperplasia. ANG2 inhibition blocked VE-cadherin phosphorylation at tyrosine residue 685 and the concomitant formation of button-like junctions in initial lymphatics. The defective junctions were associated with impaired lymph uptake. In collecting lymphatics, adherens junctions were disrupted, and the vessels leaked upon ANG2 blockade or gene deletion. ANG2 inhibition also suppressed the onset of lymphatic valve formation and subsequent valve maturation. These data identify ANG2 as the first essential regulator of the functionally important interendothelial cell–cell junctions that form during lymphatic development. PMID:25030698

  14. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.

    PubMed

    Zheng, Wei; Nurmi, Harri; Appak, Sila; Sabine, Amélie; Bovay, Esther; Korhonen, Emilia A; Orsenigo, Fabrizio; Lohela, Marja; D'Amico, Gabriela; Holopainen, Tanja; Leow, Ching Ching; Dejana, Elisabetta; Petrova, Tatiana V; Augustin, Hellmut G; Alitalo, Kari

    2014-07-15

    Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting lymphatics during development. Lymphatic endothelial cell (LEC) junctions in initial lymphatics transform from a zipper-like to a button-like pattern during collecting vessel development, but what regulates this process is largely unknown. Angiopoietin 2 (Ang2) deficiency leads to abnormal lymphatic vessels. Here we found that an ANG2-blocking antibody inhibited embryonic lymphangiogenesis, whereas endothelium-specific ANG2 overexpression induced lymphatic hyperplasia. ANG2 inhibition blocked VE-cadherin phosphorylation at tyrosine residue 685 and the concomitant formation of button-like junctions in initial lymphatics. The defective junctions were associated with impaired lymph uptake. In collecting lymphatics, adherens junctions were disrupted, and the vessels leaked upon ANG2 blockade or gene deletion. ANG2 inhibition also suppressed the onset of lymphatic valve formation and subsequent valve maturation. These data identify ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development. PMID:25030698

  15. Multivariate Calibration and Model Integrity for Wood Chemistry Using Fourier Transform Infrared Spectroscopy

    PubMed Central

    Zhou, Chengfeng; Jiang, Wei; Cheng, Qingzheng; Via, Brian K.

    2015-01-01

    This research addressed a rapid method to monitor hardwood chemical composition by applying Fourier transform infrared (FT-IR) spectroscopy, with particular interest in model performance for interpretation and prediction. Partial least squares (PLS) and principal components regression (PCR) were chosen as the primary models for comparison. Standard laboratory chemistry methods were employed on a mixed genus/species hardwood sample set to collect the original data. PLS was found to provide better predictive capability while PCR exhibited a more precise estimate of loading peaks and suggests that PCR is better for model interpretation of key underlying functional groups. Specifically, when PCR was utilized, an error in peak loading of ±15 cm−1 from the true mean was quantified. Application of the first derivative appeared to assist in improving both PCR and PLS loading precision. Research results identified the wavenumbers important in the prediction of extractives, lignin, cellulose, and hemicellulose and further demonstrated the utility in FT-IR for rapid monitoring of wood chemistry. PMID:26576321

  16. Integration of sexual trauma in a religious narrative: Transformation, resolution and growth among contemplative nuns

    PubMed Central

    Littlewood, Roland; Leavey, Gerard

    2013-01-01

    The psychological consequences of sexual abuse are generally serious and enduring, particularly when the perpetrator is known and trusted by the survivor. This paper explores the experiences of five contemplative nuns who were sexually abused by priests and the spiritual journeys that followed. In the context of an ethnographic study of contemplative practice, participant observation and in-depth interviews were used to examine the ways that the nuns sought to make sense of their experiences through a long process of solitary introspection. The pursuit of meaning was shaped by religious beliefs relating to forgiveness, sacrifice, and salvation. Thus, trauma was transformed into a symbolic religious narrative that shaped their sense of identity. They were able to restructure core beliefs and to manage their current relationships with priests more securely. They described regaining their spiritual well-being in ways that suggest a form of posttraumatic spiritual growth. We conclude by discussing the findings in the light of the existing literature on the interaction of trauma and spirituality. PMID:23296289

  17. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.

    PubMed

    Zheng, Wei; Nurmi, Harri; Appak, Sila; Sabine, Amélie; Bovay, Esther; Korhonen, Emilia A; Orsenigo, Fabrizio; Lohela, Marja; D'Amico, Gabriela; Holopainen, Tanja; Leow, Ching Ching; Dejana, Elisabetta; Petrova, Tatiana V; Augustin, Hellmut G; Alitalo, Kari

    2014-07-15

    Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting lymphatics during development. Lymphatic endothelial cell (LEC) junctions in initial lymphatics transform from a zipper-like to a button-like pattern during collecting vessel development, but what regulates this process is largely unknown. Angiopoietin 2 (Ang2) deficiency leads to abnormal lymphatic vessels. Here we found that an ANG2-blocking antibody inhibited embryonic lymphangiogenesis, whereas endothelium-specific ANG2 overexpression induced lymphatic hyperplasia. ANG2 inhibition blocked VE-cadherin phosphorylation at tyrosine residue 685 and the concomitant formation of button-like junctions in initial lymphatics. The defective junctions were associated with impaired lymph uptake. In collecting lymphatics, adherens junctions were disrupted, and the vessels leaked upon ANG2 blockade or gene deletion. ANG2 inhibition also suppressed the onset of lymphatic valve formation and subsequent valve maturation. These data identify ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development.

  18. A new technique for decoupling the host and nuclear spectra of type I AGNs using integral field spectroscopy

    NASA Astrophysics Data System (ADS)

    Sánchez, S. F.; García-Lorenzo, B.; Jahnke, K.; Mediavilla, E.; González-Serrano, J. I.; Christensen, L.; Wisotzki, L.

    2006-03-01

    We have developed a new technique to decouple the spectra of the host and the nucleus of type I AGNs using integral field spectroscopy (IFS) data. The technique is a simple extension of methods widely tested in 2D imaging. We present here the results from applying the technique to data taken with INTEGRAL at the 4.2m WHT telescope on the Seyfert 1 radio-galaxy 3C 120. We obtained, for the first time, a clean spectra of the host galaxy, without contamination from the nuclear source.

  19. Fast and accurate computation of system matrix for area integral model-based algebraic reconstruction technique

    NASA Astrophysics Data System (ADS)

    Zhang, Shunli; Zhang, Dinghua; Gong, Hao; Ghasemalizadeh, Omid; Wang, Ge; Cao, Guohua

    2014-11-01

    Iterative algorithms, such as the algebraic reconstruction technique (ART), are popular for image reconstruction. For iterative reconstruction, the area integral model (AIM) is more accurate for better reconstruction quality than the line integral model (LIM). However, the computation of the system matrix for AIM is more complex and time-consuming than that for LIM. Here, we propose a fast and accurate method to compute the system matrix for AIM. First, we calculate the intersection of each boundary line of a narrow fan-beam with pixels in a recursive and efficient manner. Then, by grouping the beam-pixel intersection area into six types according to the slopes of the two boundary lines, we analytically compute the intersection area of the narrow fan-beam with the pixels in a simple algebraic fashion. Overall, experimental results show that our method is about three times faster than the Siddon algorithm and about two times faster than the distance-driven model (DDM) in computation of the system matrix. The reconstruction speed of our AIM-based ART is also faster than the LIM-based ART that uses the Siddon algorithm and DDM-based ART, for one iteration. The fast reconstruction speed of our method was accomplished without compromising the image quality.

  20. Subdivision based isogeometric analysis technique for electric field integral equations for simply connected structures

    NASA Astrophysics Data System (ADS)

    Li, Jie; Dault, Daniel; Liu, Beibei; Tong, Yiying; Shanker, Balasubramaniam

    2016-08-01

    The analysis of electromagnetic scattering has long been performed on a discrete representation of the geometry. This representation is typically continuous but not differentiable. The need to define physical quantities on this geometric representation has led to development of sets of basis functions that need to satisfy constraints at the boundaries of the elements/tessellations (viz., continuity of normal or tangential components across element boundaries). For electromagnetics, these result in either curl/div-conforming basis sets. The geometric representation used for analysis is in stark contrast with that used for design, wherein the surface representation is higher order differentiable. Using this representation for both geometry and physics on geometry has several advantages, and is elucidated in Hughes et al. (2005) [7]. Until now, a bulk of the literature on isogeometric methods have been limited to solid mechanics, with some effort to create NURBS based basis functions for electromagnetic analysis. In this paper, we present the first complete isogeometry solution methodology for the electric field integral equation as applied to simply connected structures. This paper systematically proceeds through surface representation using subdivision, definition of vector basis functions on this surface, to fidelity in the solution of integral equations. We also present techniques to stabilize the solution at low frequencies, and impose a Calderón preconditioner. Several results presented serve to validate the proposed approach as well as demonstrate some of its capabilities.

  1. The Attending Nurse Caring Model: integrating theory, evidence and advanced caring-healing therapeutics for transforming professional practice.

    PubMed

    Watson, Jean; Foster, Roxie

    2003-05-01

    This paper presents a proposed model: The Attending Nursing Caring Model (ANCM) as an exemplar for advancing and transforming nursing practice within a reflective, theoretical and evidence-based context. Watson's theory of human caring is used as a guide for integrating theory, evidence and advanced therapeutics in the area of children's pain. The ANCM is offered as a programme for renewing the profession and its professional practices of caring-healing arts and science, during an era of decline, shortages, and crises in care, safety, and hospital and health reform. The ANCM elevates contemporary nursing's caring values, relationships, therapeutics and responsibilities to a higher/deeper order of caring science and professionalism, intersecting with other professions, while sustaining the finest of its heritage and traditions of healing.

  2. Integrating Nanostructured Artificial Receptors with Whispering Gallery Mode Optical Microresonators via Inorganic Molecular Imprinting Techniques

    PubMed Central

    Hammond, G. Denise; Vojta, Adam L.; Grant, Sheila A.; Hunt, Heather K.

    2016-01-01

    The creation of label-free biosensors capable of accurately detecting trace contaminants, particularly small organic molecules, is of significant interest for applications in environmental monitoring. This is achieved by pairing a high-sensitivity signal transducer with a biorecognition element that imparts selectivity towards the compound of interest. However, many environmental pollutants do not have corresponding biorecognition elements. Fortunately, biomimetic chemistries, such as molecular imprinting, allow for the design of artificial receptors with very high selectivity for the target. Here, we perform a proof-of-concept study to show how artificial receptors may be created from inorganic silanes using the molecular imprinting technique and paired with high-sensitivity transducers without loss of device performance. Silica microsphere Whispering Gallery Mode optical microresonators are coated with a silica thin film templated by a small fluorescent dye, fluorescein isothiocyanate, which serves as our model target. Oxygen plasma degradation and solvent extraction of the template are compared. Extracted optical devices are interacted with the template molecule to confirm successful sorption of the template. Surface characterization is accomplished via fluorescence and optical microscopy, ellipsometry, optical profilometry, and contact angle measurements. The quality factors of the devices are measured to evaluate the impact of the coating on device sensitivity. The resulting devices show uniform surface coating with no microstructural damage with Q factors above 106. This is the first report demonstrating the integration of these devices with molecular imprinting techniques, and could lead to new routes to biosensor creation for environmental monitoring. PMID:27314397

  3. A novel solubilization technique for poorly soluble drugs through the integration of nanocrystal and cocrystal technologies.

    PubMed

    Karashima, Masatoshi; Kimoto, Kouya; Yamamoto, Katsuhiko; Kojima, Takashi; Ikeda, Yukihiro

    2016-10-01

    The aim of the present study was to develop a novel solubilization technique consisting of a nano-cocrystal suspension by integrating cocrystal and nanocrystal formulation technologies to maximize solubilization over current solubilizing technologies. Monodisperse carbamazepine-saccharin, indomethacin-saccharin, and furosemide-caffeine nano-cocrystal suspensions, as well as a furosemide-cytosine nano-salt suspension, were successfully prepared with particle sizes of less than 300nm by wet milling with the stabilizers hydroxypropyl methylcellulose and sodium dodecyl sulfate. Interestingly, the properties of resultant nano-cocrystal suspensions were dramatically changed depending on the physicochemical and structural properties of the cocrystals. In the formulation optimization, the concentration and ratio of the stabilizers also influenced the zeta potentials and particles sizes of the resultant nano-cocrystal suspensions. Raman spectroscopic analysis revealed that the crystalline structures of the cocrystals were maintained in the nanosuspensions, and were physically stable for at least one month. Furthermore, their dissolution profiles were significantly improved over current solubilization-enabling technologies, nanocrystals, and cocrystals. In the present study, we demonstrated that nano-cocrystal formulations can be a new promising option for solubilization techniques to improve the absorption of poorly soluble drugs, and can expand the development potential of poorly soluble candidates in the pharmaceutical industry. PMID:27393561

  4. Integrating Nanostructured Artificial Receptors with Whispering Gallery Mode Optical Microresonators via Inorganic Molecular Imprinting Techniques.

    PubMed

    Hammond, G Denise; Vojta, Adam L; Grant, Sheila A; Hunt, Heather K

    2016-01-01

    The creation of label-free biosensors capable of accurately detecting trace contaminants, particularly small organic molecules, is of significant interest for applications in environmental monitoring. This is achieved by pairing a high-sensitivity signal transducer with a biorecognition element that imparts selectivity towards the compound of interest. However, many environmental pollutants do not have corresponding biorecognition elements. Fortunately, biomimetic chemistries, such as molecular imprinting, allow for the design of artificial receptors with very high selectivity for the target. Here, we perform a proof-of-concept study to show how artificial receptors may be created from inorganic silanes using the molecular imprinting technique and paired with high-sensitivity transducers without loss of device performance. Silica microsphere Whispering Gallery Mode optical microresonators are coated with a silica thin film templated by a small fluorescent dye, fluorescein isothiocyanate, which serves as our model target. Oxygen plasma degradation and solvent extraction of the template are compared. Extracted optical devices are interacted with the template molecule to confirm successful sorption of the template. Surface characterization is accomplished via fluorescence and optical microscopy, ellipsometry, optical profilometry, and contact angle measurements. The quality factors of the devices are measured to evaluate the impact of the coating on device sensitivity. The resulting devices show uniform surface coating with no microstructural damage with Q factors above 10⁶. This is the first report demonstrating the integration of these devices with molecular imprinting techniques, and could lead to new routes to biosensor creation for environmental monitoring. PMID:27314397

  5. A Study on Integrated Community Based Flood Mitigation with Remote Sensing Technique in Kota Bharu, Kelantan

    NASA Astrophysics Data System (ADS)

    'Ainullotfi, A. A.; Ibrahim, A. L.; Masron, T.

    2014-02-01

    This study is conducted to establish a community based flood management system that is integrated with remote sensing technique. To understand local knowledge, the demographic of the local society is obtained by using the survey approach. The local authorities are approached first to obtain information regarding the society in the study areas such as the population, the gender and the tabulation of settlement. The information about age, religion, ethnic, occupation, years of experience facing flood in the area, are recorded to understand more on how the local knowledge emerges. Then geographic data is obtained such as rainfall data, land use, land elevation, river discharge data. This information is used to establish a hydrological model of flood in the study area. Analysis were made from the survey approach to understand the pattern of society and how they react to floods while the analysis of geographic data is used to analyse the water extent and damage done by the flood. The final result of this research is to produce a flood mitigation method with a community based framework in the state of Kelantan. With the flood mitigation that involves the community's understanding towards flood also the techniques to forecast heavy rainfall and flood occurrence using remote sensing, it is hope that it could reduce the casualties and damage that might cause to the society and infrastructures in the study area.

  6. Heat Transfer Study of Heat-Integrated Distillation Column (HIDiC) Using Simulation Techniques

    NASA Astrophysics Data System (ADS)

    Pulido, Jeffrey León; Martínez, Edgar Leonardo; Wolf, Maria Regina; Filho, Rubens Maciel

    2011-08-01

    Separation processes is largely used in petroleum refining and alcohol industries. Distillation columns consume a huge amount of energy in industrial process. Therefore, the concept of Heat-Integrated Distillation Column (HIDiC) was studied using simulation techniques in order to overcome this drawback. In this configuration the column is composed for two concentric sections called rectifying and stripping. The heat transfer is conducted from the rectifying section (which works at higher pressure and temperature) to the stripping section (which works at lower pressure and temperature) using the heat present in the process and decreasing the energy charge required by the reboiler. The HIDiC column offers great potential to reduce energy consumption compared to conventional columns. However, the complexity of the internal configuration requires the development of rigorous works that enable a better understanding of the column operation. For this reason, techniques of simulation were used through of computational software. The current work presents a heat transfer study in a concentric stage of a HIDiC column. The results obtained by Aspen Plus and CFD simulation showed the internal heat transfer in a concentric tray as a promissory configuration in order to decrease energy consumption in distillation processes.

  7. An integrated system to monitor landslide surface movements by means of geodetic techniques

    NASA Astrophysics Data System (ADS)

    Pesci, A.; Baldi, P.; Bedin, A.; Casula, G.; Cenni, N.; Fabris, M.; Loddo, F.; Mora, P.

    2003-04-01

    The application of GPS, Digital Photogrammetry and Laser Scanning to landslide represent a powerfool tool for movement monitoring including small deformation preceding the failure phase. These techniques are applied leading to an integrated system to generate Digital Elevation Models. The GPS gives the possibility of determining the relative position of points at centimetric and/or millimetric accuracy by means of fast survey operations. The application of this technique in the so-called kinematic mode, that is moving continuously one receiver with respect to a reference fixed station, allows the description of the terrain surface measuring the coordinates of points distributed on a high density irregular grid. Moreover Static and Fast Static GPS mode provide an efficient means for determining the position at millimetric level of precision of marker points distributed along the interested area. Continuous observations of landslide surface displacement may be performed by means of GPS permanent station monitored from a remote control centre, and the possibility of automating the main GPS operational steps (observation, collection, downloading and processing) make it possible to control landslide activity in real time. The Digital Photogrammetry provide the measurement of shape, position and dimension of objects on a surface from stereo photographs. Combined with surveying of control points, photogrammetric techniques can be applied to generate DEMs. Aerial and terrestrial images are automatically processed by means of correlation algorithms that work at sub-pixel level. The precision of the computation of three dimensional coordinates of points depends mainly on the scale and the resolution of the image. The Laser Scanning technique is based on determining distances measuring the round trip time of a laser wave: for each point shot by the laser beam, the telemeter provide the distances, the reflectance and the coordinates of a high number of surface points in a

  8. Calculus Technique of Integration by Parts, Correlated with a Geometric Picture

    ERIC Educational Resources Information Center

    Fromhold, Albert T., Jr.

    2005-01-01

    The method of integration by parts is one of the most useful in integral calculus. Among the most important applications is the integration of differentials involving products, differentials in involving logarithms, and differentials involving inverse circular functions.

  9. Integrated 3D density modelling and segmentation of the Dead Sea Transform

    NASA Astrophysics Data System (ADS)

    Götze, H.-J.; El-Kelani, R.; Schmidt, S.; Rybakov, M.; Hassouneh, M.; Förster, H.-J.; Ebbing, J.

    2007-04-01

    A 3D interpretation of the newly compiled Bouguer anomaly in the area of the “Dead Sea Rift” is presented. A high-resolution 3D model constrained with the seismic results reveals the crustal thickness and density distribution beneath the Arava/Araba Valley (AV), the region between the Dead Sea and the Gulf of Aqaba/Elat. The Bouguer anomalies along the axial portion of the AV, as deduced from the modelling results, are mainly caused by deep-seated sedimentary basins ( D > 10 km). An inferred zone of intrusion coincides with the maximum gravity anomaly on the eastern flank of the AV. The intrusion is displaced at different sectors along the NNW-SSE direction. The zone of maximum crustal thinning (depth 30 km) is attained in the western sector at the Mediterranean. The southeastern plateau, on the other hand, shows by far the largest crustal thickness of the region (38-42 km). Linked to the left lateral movement of approx. 105 km at the boundary between the African and Arabian plate, and constrained with recent seismic data, a small asymmetric topography of the Moho beneath the Dead Sea Transform (DST) was modelled. The thickness and density of the crust suggest that the AV is underlain by continental crust. The deep basins, the relatively large intrusion and the asymmetric topography of the Moho lead to the conclusion that a small-scale asthenospheric upwelling could be responsible for the thinning of the crust and subsequent creation of the Dead Sea basin during the left lateral movement. A clear segmentation along the strike of the DST was obtained by curvature analysis: the northern part in the neighbourhood of the Dead Sea is characterised by high curvature of the residual gravity field. Flexural rigidity calculations result in very low values of effective elastic lithospheric thickness ( t e < 5 km). This points to decoupling of crust in the Dead Sea area. In the central, AV the curvature is less pronounced and t e increases to approximately 10 km

  10. Caring Science: Transforming the Ethic of Caring-Healing Practice, Environment, and Culture within an Integrated Care Delivery System.

    PubMed

    Foss Durant, Anne; McDermott, Shawna; Kinney, Gwendolyn; Triner, Trudy

    2015-01-01

    In early 2010, leaders within Kaiser Permanente (KP) Northern California's Patient Care Services division embarked on a journey to embrace and embed core tenets of Caring Science into the practice, environment, and culture of the organization. Caring Science is based on the philosophy of Human Caring, a theory articulated by Jean Watson, PhD, RN, AHN-BC, FAAN, as a foundational covenant to guide nursing as a discipline and a profession. Since 2010, Caring Science has enabled KP Northern California to demonstrate its commitment to being an authentic person- and family-centric organization that promotes and advocates for total health. This commitment empowers KP caregivers to balance the art and science of clinical judgment by considering the needs of the whole person, honoring the unique perception of health and healing that each member or patient holds, and engaging with them to make decisions that nurture their well-being. The intent of this article is two-fold: 1) to provide context and background on how a professional practice framework was used to transform the ethic of caring-healing practice, environment, and culture across multiple hospitals within an integrated delivery system; and 2) to provide evidence on how integration of Caring Science across administrative, operational, and clinical areas appears to contribute to meaningful patient quality and health outcomes. PMID:26828076

  11. Caring Science: Transforming the Ethic of Caring-Healing Practice, Environment, and Culture within an Integrated Care Delivery System.

    PubMed

    Foss Durant, Anne; McDermott, Shawna; Kinney, Gwendolyn; Triner, Trudy

    2015-01-01

    In early 2010, leaders within Kaiser Permanente (KP) Northern California's Patient Care Services division embarked on a journey to embrace and embed core tenets of Caring Science into the practice, environment, and culture of the organization. Caring Science is based on the philosophy of Human Caring, a theory articulated by Jean Watson, PhD, RN, AHN-BC, FAAN, as a foundational covenant to guide nursing as a discipline and a profession. Since 2010, Caring Science has enabled KP Northern California to demonstrate its commitment to being an authentic person- and family-centric organization that promotes and advocates for total health. This commitment empowers KP caregivers to balance the art and science of clinical judgment by considering the needs of the whole person, honoring the unique perception of health and healing that each member or patient holds, and engaging with them to make decisions that nurture their well-being. The intent of this article is two-fold: 1) to provide context and background on how a professional practice framework was used to transform the ethic of caring-healing practice, environment, and culture across multiple hospitals within an integrated delivery system; and 2) to provide evidence on how integration of Caring Science across administrative, operational, and clinical areas appears to contribute to meaningful patient quality and health outcomes.

  12. Optimization of Drive-Bunch Current Profile for Enhanced Transformer Ratio in Beam-Driven Acceleration Techniques

    SciTech Connect

    Lemery, F.; Mihalcea, D.; Prokop, C.R.; Piot, P.; /Northern Illinois U. /Fermilab

    2012-07-08

    In recent years, wakefield acceleration has gained attention due to its high acceleration gradients and cost effectiveness. In beam-driven wakefield acceleration, a critical parameter to optimize is the transformer ratio. It has been shown that current shaping of electron beams allows for enhanced (> 2) transformer ratios. In this paper we present the optimization of the pulse shape of the drive bunch for dielectric-wakefield acceleration.

  13. Integrated stochastic modeling and reservoir technique for project evaluation and risk assessment

    SciTech Connect

    Tyler, K.J.; Sandsdalen, C; M`Land, L.; Aasen, J.O.; Siring, E.; Barbieri, M.

    1996-08-01

    Uncertainties in geosciences are often down-played or neglected at the early stages of field development. In traditional reservoir studies a single reservoir description and set of dynamic reservoir properties are used for reservoir simulation. However, in the offshore field presented, large distances between exploration wells and the poor quality of seismic data resulted in little data for field appraisal and field development planning. Creative techniques for integrating the available data for better understanding of the dynamic behavior of the reservoir and quantification of uncertainty have been applied. A multidisciplinary modeling approach has been used to achieve a consistent assessment of the reservoir uncertainties for a field in project evaluation. The uncertainty in-place hydrocarbon pore volumes, including uncertainties in petro- physical properties, contact depths, segmentation, and depth conversion were included in this uncertainty. Stochastic modeling for representation of the uncertainty in sedimentology, petrology, petrophysics and geology for this tidal dominated estuarine environment. These uncertainties have been quantified in 99 realizations where ranking has been used to establish P10, P50 and P90 cases for further integration into dynamic simulation and Monte Carlo simulation. P10, P50 and P90 scenarios of heterogeneities, hydrocarbon pore volumes, and other reservoir technical parameters (i.e., skin, relative permeability and fluid properties) have been combined in dynamic reservoir simulations. Regression analysis of these simulations allowed for assessment of the uncertainties for plateau length and recoverable reserves. Monte Carlo simulation incorporating uncertainty distribution functions of the uncertain parameters was then used to obtain P10, P50 and P90 production profiles used for economical project assessment and project planning.

  14. Event triggered state estimation techniques for power systems with integrated variable energy resources.

    PubMed

    Francy, Reshma C; Farid, Amro M; Youcef-Toumi, Kamal

    2015-05-01

    For many decades, state estimation (SE) has been a critical technology for energy management systems utilized by power system operators. Over time, it has become a mature technology that provides an accurate representation of system state under fairly stable and well understood system operation. The integration of variable energy resources (VERs) such as wind and solar generation, however, introduces new fast frequency dynamics and uncertainties into the system. Furthermore, such renewable energy is often integrated into the distribution system thus requiring real-time monitoring all the way to the periphery of the power grid topology and not just the (central) transmission system. The conventional solution is two fold: solve the SE problem (1) at a faster rate in accordance with the newly added VER dynamics and (2) for the entire power grid topology including the transmission and distribution systems. Such an approach results in exponentially growing problem sets which need to be solver at faster rates. This work seeks to address these two simultaneous requirements and builds upon two recent SE methods which incorporate event-triggering such that the state estimator is only called in the case of considerable novelty in the evolution of the system state. The first method incorporates only event-triggering while the second adds the concept of tracking. Both SE methods are demonstrated on the standard IEEE 14-bus system and the results are observed for a specific bus for two difference scenarios: (1) a spike in the wind power injection and (2) ramp events with higher variability. Relative to traditional state estimation, the numerical case studies showed that the proposed methods can result in computational time reductions of 90%. These results were supported by a theoretical discussion of the computational complexity of three SE techniques. The work concludes that the proposed SE techniques demonstrate practical improvements to the computational complexity of

  15. Event triggered state estimation techniques for power systems with integrated variable energy resources.

    PubMed

    Francy, Reshma C; Farid, Amro M; Youcef-Toumi, Kamal

    2015-05-01

    For many decades, state estimation (SE) has been a critical technology for energy management systems utilized by power system operators. Over time, it has become a mature technology that provides an accurate representation of system state under fairly stable and well understood system operation. The integration of variable energy resources (VERs) such as wind and solar generation, however, introduces new fast frequency dynamics and uncertainties into the system. Furthermore, such renewable energy is often integrated into the distribution system thus requiring real-time monitoring all the way to the periphery of the power grid topology and not just the (central) transmission system. The conventional solution is two fold: solve the SE problem (1) at a faster rate in accordance with the newly added VER dynamics and (2) for the entire power grid topology including the transmission and distribution systems. Such an approach results in exponentially growing problem sets which need to be solver at faster rates. This work seeks to address these two simultaneous requirements and builds upon two recent SE methods which incorporate event-triggering such that the state estimator is only called in the case of considerable novelty in the evolution of the system state. The first method incorporates only event-triggering while the second adds the concept of tracking. Both SE methods are demonstrated on the standard IEEE 14-bus system and the results are observed for a specific bus for two difference scenarios: (1) a spike in the wind power injection and (2) ramp events with higher variability. Relative to traditional state estimation, the numerical case studies showed that the proposed methods can result in computational time reductions of 90%. These results were supported by a theoretical discussion of the computational complexity of three SE techniques. The work concludes that the proposed SE techniques demonstrate practical improvements to the computational complexity of

  16. Image accuracy and representational enhancement through low-level, multi-sensor integration techniques

    SciTech Connect

    Baker, J.E.

    1993-05-01

    Multi-Sensor Integration (MSI) is the combining of data and information from more than one source in order to generate a more reliable and consistent representation of the environment. The need for MSI derives largely from basic ambiguities inherent in our current sensor imaging technologies. These ambiguities exist as long as the mapping from reality to image is not 1-to-1. That is, if different 44 realities'' lead to identical images, a single image cannot reveal the particular reality which was the truth. MSI techniques can be divided into three categories based on the relative information content of the original images with that of the desired representation: (1) detail enhancement,'' wherein the relative information content of the original images is less rich than the desired representation; (2) data enhancement,'' wherein the MSI techniques axe concerned with improving the accuracy of the data rather than either increasing or decreasing the level of detail; and (3) conceptual enhancement,'' wherein the image contains more detail than is desired, making it difficult to easily recognize objects of interest. In conceptual enhancement one must group pixels corresponding to the same conceptual object and thereby reduce the level of extraneous detail. This research focuses on data and conceptual enhancement algorithms. To be useful in many real-world applications, e.g., autonomous or teleoperated robotics, real-time feedback is critical. But, many MSI/image processing algorithms require significant processing time. This is especially true of feature extraction, object isolation, and object recognition algorithms due to their typical reliance on global or large neighborhood information. This research attempts to exploit the speed currently available in state-of-the-art digitizers and highly parallel processing systems by developing MSI algorithms based on pixel rather than global-level features.

  17. Image accuracy and representational enhancement through low-level, multi-sensor integration techniques

    SciTech Connect

    Baker, J.E.

    1993-05-01

    Multi-Sensor Integration (MSI) is the combining of data and information from more than one source in order to generate a more reliable and consistent representation of the environment. The need for MSI derives largely from basic ambiguities inherent in our current sensor imaging technologies. These ambiguities exist as long as the mapping from reality to image is not 1-to-1. That is, if different 44 realities`` lead to identical images, a single image cannot reveal the particular reality which was the truth. MSI techniques can be divided into three categories based on the relative information content of the original images with that of the desired representation: (1) ``detail enhancement,`` wherein the relative information content of the original images is less rich than the desired representation; (2) ``data enhancement,`` wherein the MSI techniques axe concerned with improving the accuracy of the data rather than either increasing or decreasing the level of detail; and (3) ``conceptual enhancement,`` wherein the image contains more detail than is desired, making it difficult to easily recognize objects of interest. In conceptual enhancement one must group pixels corresponding to the same conceptual object and thereby reduce the level of extraneous detail. This research focuses on data and conceptual enhancement algorithms. To be useful in many real-world applications, e.g., autonomous or teleoperated robotics, real-time feedback is critical. But, many MSI/image processing algorithms require significant processing time. This is especially true of feature extraction, object isolation, and object recognition algorithms due to their typical reliance on global or large neighborhood information. This research attempts to exploit the speed currently available in state-of-the-art digitizers and highly parallel processing systems by developing MSI algorithms based on pixel rather than global-level features.

  18. Integrated atomic force microscopy techniques for analysis of biomaterials: Study of membrane proteins

    NASA Astrophysics Data System (ADS)

    Connelly, Laura S.

    Atomic Force Microscopy (AFM) is the prominent techniques for structural studies of biological materials in physiological relevant fluidic environments. AFM has been used to resolve the three-dimensional (3D) surface structure of cells, membranes, and proteins structures. Ion channels, formed by membrane proteins, are the key structures that control the activity of all living systems. This dissertation focuses on the structural evaluation of membrane proteins through atomic force microscopy. In Part I, AFM is utilized to study one of the most prominent medical issues facing our society, Alzheimer's Disease (AD). AD is a misfolded protein disease characterized by the accumulation of beta-amyloid (Abeta) peptide as senile plaques, progressive neurodegeneration, and memory loss. Recent evidence suggests that AD pathology is linked to the destabilization of cellular ionic homeostasis mediated by toxic channel structures composed of Abeta peptides. Selectively engineered sequences of Abeta were examined by AFM to elucidate the substructures and thus activity Abeta channels. Key residues were evaluated with the intent better understand the exact nature by which these pores conduct electrical and molecular signals, which could aid in identifying potential therapeutic targets for the prevention/treatment of AD. Additionally, AFM was used to analyze brain derived Abeta and newly developed pharmacological agents to study membranes and Abeta. Part II, presents a novel technology that incorporates electrophysiology into the AFM interface, enabling simultaneous imaging and complementary conductance measurements. The activity of ion channels is studied by various techniques, including patch clamp, free standing lipid bilayers, droplet interface bilayers, and supported lipid bilayers. However, direct correlation with channel structures has remained a challenge. The integrated atomic force microscopy system presented offers a solution to this challenge. The functionality of the

  19. Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage.

    PubMed

    Virén, T; Huang, Y P; Saarakkala, S; Pulkkinen, H; Tiitu, V; Linjama, A; Kiviranta, I; Lammi, M J; Brünott, A; Brommer, H; Van Weeren, R; Brama, P A J; Zheng, Y P; Jurvelin, J S; Töyräs, J

    2012-04-01

    The aim of this study was to compare sensitivity of ultrasound and optical coherence tomography (OCT) techniques for the evaluation of the integrity of spontaneously repaired horse cartilage. Articular surfaces of horse intercarpal joints, featuring both intact tissue and spontaneously healed chondral or osteochondral defects, were imaged ex vivo with arthroscopic ultrasound and laboratory OCT devices. Quantitative ultrasound (integrated reflection coefficient (IRC), apparent integrated backscattering coefficient (AIB) and ultrasound roughness index (URI)) and optical parameters (optical reflection coefficient (ORC), optical roughness index (ORI) and optical backscattering (OBS)) were determined and compared with histological integrity and mechanical properties of the tissue. Spontaneously healed tissue could be quantitatively discerned from the intact tissue with ultrasound and OCT techniques. Furthermore, several significant correlations (p < 0.05) were detected between ultrasound and OCT parameters. Superior resolution of OCT provided a more accurate measurement of cartilage surface roughness, while the ultrasound backscattering from the inner structures of the cartilage matched better with the histological findings. Since the techniques were found to be complementary to each other, dual modality imaging techniques could provide a useful tool for the arthroscopic evaluation of the integrity of articular cartilage.

  20. Applied Focused Ion Beam Techniques for Sample Preparation of Astromaterials for Integrated Nano-Analysis

    SciTech Connect

    Graham, G A; Teslich, N E; Kearsley, A T; Stadermann, F J; Stroud, R M; Dai, Z R; Ishii, H A; Hutcheon, I D; Bajt, S; Snead, C J; Weber, P K; Bradley, J P

    2007-02-20

    Sample preparation is always a critical step in study of micrometer sized astromaterials available for study in the laboratory, whether their subsequent analysis is by electron microscopy or secondary ion mass spectrometry. A focused beam of gallium ions has been used to prepare electron transparent sections from an interplanetary dust particle, as part of an integrated analysis protocol to maximize the mineralogical, elemental, isotopic and spectroscopic information extracted from one individual particle. In addition, focused ion beam techniques have been employed to extract cometary residue preserved on the rims and walls of micro-craters in 1100 series aluminum foils that were wrapped around the sample tray assembly on the Stardust cometary sample collector. Non-ideal surface geometries and inconveniently located regions of interest required creative solutions. These include support pillar construction and relocation of a significant portion of sample to access a region of interest. Serial sectioning, in a manner similar to ultramicrotomy, is a significant development and further demonstrates the unique capabilities of focused ion beam microscopy for sample preparation of astromaterials.

  1. New integration techniques for chemical kinetic rate equations. I - Efficiency comparison

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, K.

    1986-01-01

    A comparison of the efficiency of several recently developed numerical techniques for solving chemical kinetic rate equations is presented. The solution procedures examined include two general-purpose codes, EPISODE and LSODE, developed as multipurpose differential equation solvers, and three specialzed codes, CHEMEQ, CREK1D, and GCKP84, developed specifically for chemical kinetics. The efficiency comparison is made by applying these codes to two practical combustion kinetics problems. Both problems describe adiabatic, constant-pressure, gas-phase chemical reactions and include all three combustion regimes: induction, heat release, and equilibration. The comparison shows that LSODE is the fastest routine currently available for solving chemical kinetic rate equations. An important finding is that an iterative solution of the algebraic enthalpy conservation equation for temperature can be significantly faster than evaluation of the temperature by integration of its time derivative. Significant increases in computational speed are realized by updating the reaction rate constants only when the temperature change exceeds an amount Delta-T that is problem dependent. An approximate expression for the automatic evaluation of Delta-T is presented and is shown to result in increased computational speed.

  2. Integrating remote sensing techniques at Cuprite, Nevada: AVIRIS, Thematic Mapper, and field spectroscopy

    NASA Technical Reports Server (NTRS)

    Hill, Bradley; Nash, Greg; Ridd, Merrill; Hauff, Phoebe L.; Ebel, Phil

    1992-01-01

    The Cuprite mining district in southwestern Nevada has become a test site for remote sensing studies with numerous airborne scanners and ground sensor data sets collected over the past fifteen years. Structurally, the Cuprite region can be divided into two areas with slightly different alteration and mineralogy. These zones lie on either side of a postulated low-angle structural discontinuity that strikes nearly parallel to US Route 95. Hydrothermal alternation at Cuprite was classified into three major zones: silicified, opalized, and argillized. These alteration types form a bulls-eye pattern east of the highway and are more linear on the west side of the highway making a striking contrast from the air and the imagery. Cuprite is therefore an ideal location for remote sensing research as it exhibits easily identified hydrothermal zoning, is relatively devoid of vegetation, and contains a distinctive spectrally diagnostic mineral suite including the ammonium feldspar buddingtonite, several types of alunite, different jarosites, illite, kaolinite, smectite, dickite, and opal. This present study brings a new dimension to these previous remote sensing and ground data sets compiled for Cuprite. The development of a higher resolution field spectrometer now provides the capability to combine extensive in-situ mineralogical data with a new geologic field survey and detailed Airborne Visible/Infrared Imaging Spectrometers (AVIRIS) images. The various data collection methods and the refinement of the integrated techniques are discussed.

  3. Multiple-mode Lamb wave scattering simulations using 3D elastodynamic finite integration technique.

    PubMed

    Leckey, Cara A C; Rogge, Matthew D; Miller, Corey A; Hinders, Mark K

    2012-02-01

    We have implemented three-dimensional (3D) elastodynamic finite integration technique (EFIT) simulations to model Lamb wave scattering for two flaw-types in an aircraft-grade aluminum plate, a rounded rectangle flat-bottom hole and a disbond of the same shape. The plate thickness and flaws explored in this work include frequency-thickness regions where several Lamb wave modes exist and sometimes overlap in phase and/or group velocity. For the case of the flat-bottom hole the depth was incrementally increased to explore progressive changes in multiple-mode Lamb wave scattering due to the damage. The flat-bottom hole simulation results have been compared to experimental data and are shown to provide key insight for this well-defined experimental case by explaining unexpected results in experimental waveforms. For the rounded rectangle disbond flaw, which would be difficult to implement experimentally, we found that Lamb wave behavior differed significantly from the flat-bottom hole flaw. Most of the literature in this field is restricted to low frequency-thickness regions due to difficulties in interpreting data when multiple modes exist. We found that benchmarked 3D EFIT simulations can yield an understanding of scattering behavior for these higher frequency-thickness regions and in cases that would be difficult to set up experimentally. Additionally, our results show that 2D simulations would not have been sufficient for modeling the complicated scattering that occurred. PMID:21908011

  4. Integrative Utilization of Microenvironments, Biomaterials and Computational Techniques for Advanced Tissue Engineering.

    PubMed

    Shamloo, Amir; Mohammadaliha, Negar; Mohseni, Mina

    2015-10-20

    This review aims to propose the integrative implementation of microfluidic devices, biomaterials, and computational methods that can lead to a significant progress in tissue engineering and regenerative medicine researches. Simultaneous implementation of multiple techniques can be very helpful in addressing biological processes. Providing controllable biochemical and biomechanical cues within artificial extracellular matrix similar to in vivo conditions is crucial in tissue engineering and regenerative medicine researches. Microfluidic devices provide precise spatial and temporal control over cell microenvironment. Moreover, generation of accurate and controllable spatial and temporal gradients of biochemical factors is attainable inside microdevices. Since biomaterials with tunable properties are a worthwhile option to construct artificial extracellular matrix, in vitro platforms that simultaneously utilize natural, synthetic, or engineered biomaterials inside microfluidic devices are phenomenally advantageous to experimental studies in the field of tissue engineering. Additionally, collaboration between experimental and computational methods is a useful way to predict and understand mechanisms responsible for complex biological phenomena. Computational results can be verified by using experimental platforms. Computational methods can also broaden the understanding of the mechanisms behind the biological phenomena observed during experiments. Furthermore, computational methods are powerful tools to optimize the fabrication of microfluidic devices and biomaterials with specific features. Here we present a succinct review of the benefits of microfluidic devices, biomaterial, and computational methods in the case of tissue engineering and regeneration medicine. Furthermore, some breakthroughs in biological phenomena including the neuronal axon development, cancerous cell migration and blood vessel formation via angiogenesis by virtue of the aforementioned approaches

  5. A program system for ab initio MO calculations on vector and parallel processing machines III. Integral reordering and four-index transformation

    NASA Astrophysics Data System (ADS)

    Wiest, Roland; Demuynck, Jean; Bénard, Marc; Rohmer, Marie-Madeleine; Ernenwein, René

    1991-01-01

    This series of three papers presents a program system for ab initio molecular orbital calculations on vector and parallel computers. Part III is devoted to the four-index transformation on a molecular orbital basis of size NMO of the file of two-electron integrals ( pq∥ rs) generated by a contracted Gaussian set of size NATO (number of atomic orbitals). A fast Yoshimine algorithm first sorts the ( pq∥ rs) integrals with respect to index pq only. This file of half-sorted integrals labelled by their rs-index can be processed without further modification to generate either the transformed integrals or the supermatrix elements. The large memory available on the CRAY-2 has made possible to implement the transformation algorithm proposed by Bender in 1972, which requires a core-storage allocation varying as (NATO) 3. Two versions of Bender's algorithm are included in the present program. The first version is an in-core version, where the complete file of accumulated contributions to transformed integrals is stored and updated in central memory. This version has been parallelized by distributing over a limited number of logical tasks the NATO steps corresponding to the scanning of the most external loop. The second version is an out-of-core version, in which twin fires are alternatively used as input and output for the accumulated contributions to transformed integrals. This version is not parallel. The choice of one or another version and (for version 1) the determination of the number of tasks depends upon the balance between the available and the requested amounts of storage. The storage management and the choice of the proper version are carried out automatically using dynamic storage allocation. Both versions are vectorized and take advantage of the molecular symmetry.

  6. Integration site of polyoma virus DNA in the inducible LPT line of polyoma-transformed rat cells.

    PubMed Central

    Mendelsohn, E; Baran, N; Neer, A; Manor, H

    1982-01-01

    The structure of the polyoma virus (Py) integration site in the inducible LPT line of Py-transformed rat cells was determined by biochemical methods of gene mapping. LPT cell DNA was digested with various restriction enzymes. The digestion products were electrophoresed in agarose gels and transferred onto nitrocellulose sheets by Southern blotting. Fragments containing viral or cell DNA sequences, or both, were identified by hybridization with Py DNA or with a cloned flanking cell DNA probe. Cleavage of LPT DNA with enzymes that restrict the Py genome once generated linear Py DNA molecules and two fragments containing both cell and viral DNA sequences. Cleavage of LPT DNA with enzymes which do not restrict Py DNA generated series of fragments whose lengths were found to differ by increments of a whole Py genome; the smallest fragment in each series was found to be longer than the viral genome. These data indicate that LPT cultures contain Py insertions of various lengths integrated into the same chromosomal site in all the cells. The length heterogeneity of the viral insertions is due to the presence of 0, 1, 2, 3. . . Py genomes arranged in a direct tandem repeat within invariable sequences of viral DNA. Double-digestion experiments were also carried out with the above enzymes and with enzymes that cleave the Py genome at multiple sites. The data obtained in these experiments were used to construct a physical map of the integration site. This map showed that the early region of the virus remained intact even in the smallest insertion (which contains no whole duplicated genomes), whereas the late region was partially duplicated and split during integration. The smallest insertion is colinear with the Py physical map over a region including the entire Py genome and at least a part of the duplicated segment. This structure could give rise to nondefective circular viral DNA molecules by single homologous recombination events. Similar recombination events may occur at

  7. The Fourier transform method and the SD-bar approach for the analytical and numerical treatment of multicenter overlap-like quantum similarity integrals

    SciTech Connect

    Safouhi, Hassan . E-mail: hassan.safouhi@ualberta.ca; Berlu, Lilian

    2006-07-20

    Molecular overlap-like quantum similarity measurements imply the evaluation of overlap integrals of two molecular electronic densities related by Dirac delta function. When the electronic densities are expanded over atomic orbitals using the usual LCAO-MO approach (linear combination of atomic orbitals), overlap-like quantum similarity integrals could be expressed in terms of four-center overlap integrals. It is shown that by introducing the Fourier transform of delta Dirac function in the integrals and using the Fourier transform approach combined with the so-called B functions, one can obtain analytic expressions of the integrals under consideration. These analytic expressions involve highly oscillatory semi-infinite spherical Bessel functions, which are the principal source of severe numerical and computational difficulties. In this work, we present a highly efficient algorithm for a fast and accurate numerical evaluation of these multicenter overlap-like quantum similarity integrals over Slater type functions. This algorithm is based on the SD-bar approach due to Safouhi. Recurrence formulae are used for a better control of the degree of accuracy and for a better stability of the algorithm. The numerical result section shows the efficiency of our algorithm, compared with the alternatives using the one-center two-range expansion method, which led to very complicated analytic expressions, the epsilon algorithm and the nonlinear D-bar transformation.

  8. Preconditioning techniques for constrained vector potential integral equations, with application to 3-D magnetoquasistatic analysis of electronic packages

    SciTech Connect

    Kamon, M.; Phillips, J.R.

    1994-12-31

    In this paper techniques are presented for preconditioning equations generated by discretizing constrained vector integral equations associated with magnetoquasistatic analysis. Standard preconditioning approaches often fail on these problems. The authors present a specialized preconditioning technique and prove convergence bounds independent of the constraint equations and electromagnetic excitation frequency. Computational results from analyzing several electronic packaging examples are given to demonstrate that the new preconditioning approach can sometimes reduce the number of GMRES iterations by more than an order of magnitude.

  9. Nouvelle methode d'integration energetique pour la retro-installation des procedes industriels et la transformation des usines papetieres

    NASA Astrophysics Data System (ADS)

    Bonhivers, Jean-Christophe

    The increase in production of goods over the last decades has led to the need for improving the management of natural resources management and the efficiency of processes. As a consequence, heat integration methods for industry have been developed. These have been successful for the design of new plants: the integration principles are largely employed, and energy intensity has dramatically decreased in many processes. Although progress has also been achieved in integration methods for retrofit, these methods still need further conceptual development. Furthermore, methodological difficulties increase when trying to retrofit heat exchange networks that are closely interrelated to water networks, such as the case of pulp and paper mills. The pulp and paper industry seeks to increase its profitability by reducing production costs and optimizing supply chains. Recent process developments in forestry biorefining give this industry the opportunity for diversification into bio-products, increasing potential profit margins, and at the same time modernizing its energy systems. Identification of energy strategies for a mill in a changing environment, including the possibility of adding a biorefinery process on the industrial site, requires better integration methods for retrofit situations. The objective of this thesis is to develop an energy integration method for the retrofit of industrial systems and the transformation of pulp and paper mills, ant to demonstrate the method in case studies. Energy is conserved and degraded in a process. Heat can be converted into electricity, stored as chemical energy, or rejected to the environment. A systematic analysis of successive degradations of energy between the hot utilities until the environment, through process operations and existing heat exchangers, is essential in order to reduce the heat consumption. In this thesis, the "Bridge Method" for energy integration by heat exchanger network retrofit has been developed. This method

  10. Generalized method of moments: A novel discretization technique for integral equations

    NASA Astrophysics Data System (ADS)

    Nair, Naveen V.

    Integral equation formulations to solve electromagnetic scattering and radiation problems have existed for over a century. The method of moments (MoM) technique to solve these integral equations has been in active use for over 40 years and has become one of the cornerstones of electromagnetic analysis. It has been successfully employed in a wide variety of problems ranging from scattering and antenna analysis to electromagnetic compatibility analysis to photonics. In MoM, the unknown quantity (currents or fields) is represented using a set of basis functions. This representation, together with Galerkin testing, results in a set of equations that may then be solved to obtain the coefficients of expansion. The basis functions are typically constructed on a tessellation of the geometry and its choice is critical to the accuracy of the final solution. As a result, considerable energy has been expended in the design and construction of optimal basis functions. The most common of these functions in use today are the Rao-Wilton-Glisson (RWG) functions that have become the de-facto standard and have also spawned a set of higher order complete and singular variants. However, their near-ubiquitous popularity and success notwithstanding, they come with certain important limitations. The chief among these is the intimate marriage between the underlying triangulation of the geometry and the basis function. While this coupling maintains continuity of the normal component of these functions across triangle boundaries and makes them very easy to implement, this also implies an inherent restriction on the kind of basis function spaces that can be employed. This thesis aims to address this issue and provides a novel framework for the discretization of integral equations that demonstrates several significant advantages. In this work, we will describe a new umbrella framework for the discretization of integral equations called the Generalized Method of Moments (GMM). We will show that

  11. Kinetics of electrochemically controlled surface reactions on bulk and thin film metals studied with Fourier transform impedance spectroscopy and surface plasmon resonance techniques

    NASA Astrophysics Data System (ADS)

    Assiongbon, Kankoe A.

    2005-07-01

    In the work presented in this thesis, the surface sensitive electrochemical techniques of cyclic voltametry (CV), potential step (PS) and Fourier transform impedance spectroscopy (FT-EIS), as well as the optical technique of surface plasmon resonance (SPR), were used to probe a wide variety of surface processes at various metal/liquid interface. Three polycrystalline metals (Au, Ta and Cu) and a Cr-coated gold film were used for these studies in different aqueous environments. A combination of CV with FT-EIS and PS was used to investigate electronic and structural proprieties of a modified bulk electrode of Au. This experimental system involved under potential deposition (UPD) of Bi3+ on Au in a supporting aqueous electrolyte containing ClO-4 . UPD range of Bi3+ was determined, and adsorption kinetics of Bi3+ in the presence of coadsorbing anion, ClO-4 were quantified. Potentiodynamic growth of oxide films of Ta in the following electrolytes NaNO3, NaNO3 + 5wt% H2O2, NaOH and NaOH + 5wt% H2O2 had been investigated. The oxide films were grown in the range -0.1 → +0.4V (high electric field) at a scan rate of 10 mV/s. Time resolved A.C. impedance spectroscopy measurements in the frequency range (0.1--20 KHz) were performed to characterize the surface reactions of oxide formation. The results are interpreted in terms of charge conductivity O2- through the oxide film, and disintegration of H2O2 into OH-. In a high pH medium (pH 12), dissociation of H2O2 was catalytically enhanced. This led to destabilization of the electrogenerated tantalum oxide surface film in the form of a soluble hexatantalate species. In contrast with the electrolytes, NaNO3, NaNO3 + 5wt% H2O2, NaOH, where only the oxide growth was observed, the A.C. impedance spectroscopy measurements in NaOH + 5wt% H 2O2 showed competition between oxide formation and its removal. These results are relevant for chemical slurry design in chemical mechanical polishing (CMP) of Ta. Further investigations were

  12. How Change Occurred at the Stoughton Area School District: Lessons from a SWIFT (Schoolwide Integrated Framework for Transformation) Knowledge Development Site. Issue Brief #3

    ERIC Educational Resources Information Center

    Stonemeier, Jennifer; Trader, Barbara; Kingston, Mary; Richards, Curtis; Blank, Rolf; East, Bill

    2014-01-01

    The SWIFT Center (Schoolwide Integrated Framework for Transformation) is an initiative to bring about educational equity district by district until all students excel, including students with the most profound needs. As the national technical assistance center to build schoolwide inclusive practices to improve academic and behavioral outcomes for…

  13. Improvements to Rapfish: a rapid evaluation technique for fisheries integrating ecological and human dimensions.

    PubMed

    Pitcher, T J; Lam, M E; Ainsworth, C; Martindale, A; Nakamura, K; Perry, R I; Ward, T

    2013-10-01

    This paper reports recent developments in Rapfish, a normative, scalable and flexible rapid appraisal technique that integrates both ecological and human dimensions to evaluate the status of fisheries in reference to a norm or goal. Appraisal status targets may be sustainability, compliance with a standard (such as the UN code of conduct for responsible fisheries) or the degree of progress in meeting some other goal or target. The method combines semi-quantitative (e.g. ecological) and qualitative (e.g. social) data via multiple evaluation fields, each of which is assessed through scores assigned to six to 12 attributes or indicators: the scoring method allows user flexibility to adopt a wide range of utility relationships. For assessing sustainability, six evaluation fields have been developed: ecological, technological, economic, social, ethical and institutional. Each field can be assessed directly with a set of scored attributes, or several of the fields can be dealt with in greater detail using nested subfields that themselves comprise multidimensional Rapfish assessments (e.g. the hierarchical institutional field encompasses both governance and management, including a detailed analysis of legality). The user has the choice of including all or only some of the available sustainability fields. For the attributes themselves, there will rarely be quantitative data, but scoring allows these items to be estimated. Indeed, within a normative framework, one important advantage with Rapfish is transparency of the rigour, quality and replicability of the scores. The Rapfish technique employs a constrained multidimensional ordination that is scaled to situate data points within evaluation space. Within each evaluation field, results may be presented as a two-dimensional plot or in a one-dimensional rank order. Uncertainty is expressed through the probability distribution of Monte-Carlo simulations that use the C.L. on each original observation. Overall results of the

  14. Behavioural health interventions in the Johns Hopkins Community Health Partnership: integrated care as a component of health systems transformation.

    PubMed

    Everett, Anita S; Reese, Jennifer; Coughlin, Janelle; Finan, Patrick; Smith, Michael; Fingerhood, Michael; Berkowitz, Scott; Young, J Hunter; Johnston, Diedre; Dunbar, Linda; Zollinger, Raymond; Ju, Jin; Reuland, Melissa; Strain, Eric C; Lyketsos, Constantine

    2014-12-01

    Health systems in the USA have received a mandate to improve quality while reining in costs. Several opportunities have been created to stimulate this transformation. This paper describes the design, early implementation and lessons learned for the behavioural components of the John Hopkins Community Health Partnership (J-CHiP) programme. J-CHiP is designed to improve health outcomes and reduce the total healthcare costs of a group of high healthcare use patients who are insured by the government-funded health insurance programmes, Medicaid and Medicare. These patients have a disproportionately high prevalence of depression, other psychiatric conditions, and unhealthy behaviours that could be addressed with behavioural interventions. The J-CHiP behavioural intervention is based on integrated care models, which include embedding mental health professionals into primary sites. A four-session behaviour-based protocol was developed to motivate self-efficacy through illness management skills. In addition to staff embedded in primary care, the programme design includes expedited access to specialist psychiatric services as well as a community outreach component that addresses stigma. The progress and challenges involved with developing this programme over a relatively short period of time are discussed.

  15. Influence of Cooperative Integrated Reading and Composition Technique on Foreign Students' Reading and Writing Skills in Turkish

    ERIC Educational Resources Information Center

    Varisoglu, Behice

    2016-01-01

    The purpose of this study was to reveal whether the technique of Cooperative Integrated Reading and Composition (CIRC) in Turkish Language teaching had influence on students' skills in reading and writing. In the study, the mixed method, which included quantitative and qualitative dimensions together, was used. The study group was made up of 16…

  16. An imaging evaluation of the simultaneously integrated boost breast radiotherapy technique

    SciTech Connect

    Turley, Jessica; Claridge Mackonis, Elizabeth

    2015-09-15

    To evaluate in-field megavoltage (MV) imaging of simultaneously integrated boost (SIB) breast fields to determine its feasibility in treatment verification for the SIB breast radiotherapy technique, and to assess whether the current-imaging protocol and treatment margins are sufficient. For nine patients undergoing SIB breast radiotherapy, in-field MV images of the SIB fields were acquired on days that regular treatment verification imaging was performed. The in-field images were matched offline according to the scar wire on digitally reconstructed radiographs. The offline image correction results were then applied to a margin recipe formula to calculate safe margins that account for random and systematic uncertainties in the position of the boost volume when an offline correction protocol has been applied. After offline assessment of the acquired images, 96% were within the tolerance set in the current department-imaging protocol. Retrospectively performing the maximum position deviations on the Eclipse™ treatment planning system demonstrated that the clinical target volume (CTV) boost received a minimum dose difference of 0.4% and a maximum dose difference of 1.4% less than planned. Furthermore, applying our results to the Van Herk margin formula to ensure that 90% of patients receive 95% of the prescribed dose, the calculated CTV margins were comparable to the current departmental procedure used. Based on the in-field boost images acquired and the feasible application of these results to the margin formula the current CTV-planning target volume margins used are appropriate for the accurate treatment of the SIB boost volume without additional imaging.

  17. Differential-Integral method in polymer processing: Taking melt electrospinning technique for example

    NASA Astrophysics Data System (ADS)

    Haoyi, Li; Weimin, Yang; Hongbo, Chen; Jing, Tan; Pengcheng, Xie

    2016-03-01

    A concept of Differential-Integral (DI) method applied in polymer processing and molding was proposed, which included melt DI injection molding, DI nano-composites extrusion molding and melt differential electrospinning principle and equipment. Taking the melt differential electrospinning for example to introduce the innovation research progress, two methods preparing polymer ultrafine fiber have been developed: solution electro-spinning and melt electro-spinning, between which solution electro-spinning is much simpler to realize in lab. More than 100 institutions have endeavored to conduct research on it and more than 30 thousand papers have been published. However, its industrialization was restricted to some extend because of the existence of toxic solvent during spinning process and poor mechanical strength of resultant fibers caused by small pores on fiber surface. Solvent-free melt electrospinning is environmentally friendly and highly productive. However, problems such as the high melt viscosity, thick fiber diameter and complex equipment makes it relatively under researched compared with solution electrospinning. With the purpose of solving the shortage of traditional electro-spinning equipment with needles or capillaries, a melt differential electro-spinning method without needles or capillaries was firstly proposed. Nearly 50 related patents have been applied since 2005, and systematic method innovations and experimental studies have also been conducted. The prepared fiber by this method had exhibited small diameter and smooth surface. The average fiber diameter can reach 200-800 nm, and the single nozzle can yield two orders of magnitude more than the capillaries. Based on the above principle, complete commercial techniques and equipment have been developed to produce ultra-fine non-woven fabrics for the applications in air filtration, oil spill recovery and water treatment, etc.

  18. Ring-Oven Washing Technique Integrated Paper-based Immunodevice for Sensitive Detection of Cancer Biomarker.

    PubMed

    Liu, Wei; Guo, Yumei; Zhao, Mei; Li, Huifang; Zhang, Zhujun

    2015-08-01

    A paper-based microfluidic immunodevice has recently attracted considerable interest for point-of-care testing (POCT) and a washing procedure was used as a standard procedure in immunoassay to eliminate the nonspecific binding protein from a paper surface. However, the traditional washing method cannot get rid of the nonspecific binding protein more completely to get a lower background. In this work, a novel washing strategy with a ring-oven technique integrated on a paper-based immunodevice was presented, which can effectively wash a nonspecific binding protein and enable a low background for sensitive detection of the carcinoembryonic antigen (CEA). By immobilizing the antibody on the detection area and incorporating the temperature-controlled ring-oven under the paper-based device, the continuous washing solution can carry the nonspecific binding protein to the waste area freely by capillary force and then the waste area dried quickly by heating. The paper device, which is matched to the size of the ring-oven, is composed of eight microfluidic channels by the simple and rapid paper-cutting fabrication method. With the HRP-catalyzed 3,3',5,5'-tetramethylbenzidine (TMB)-H2O2 colorimetric detection method, a lower detection limit of 0.03 ng/mL CEA can be obtained by enzyme-linked immunosorbent assay (ELISA). The washing efficiency for the nonspecific binding protein was improved a lot compared to the traditional washing methods, and the established paper-based device can be used in the determination of CEA in human serum with high sensitivity. The paper-based device provides a new washing strategy for sensitive immunoassay and point-of-care diagnostics.

  19. Modelling and calibration technique of laser triangulation sensors for integration in robot arms and articulated arm coordinate measuring machines.

    PubMed

    Santolaria, Jorge; Guillomía, David; Cajal, Carlos; Albajez, José A; Aguilar, Juan J

    2009-01-01

    A technique for intrinsic and extrinsic calibration of a laser triangulation sensor (LTS) integrated in an articulated arm coordinate measuring machine (AACMM) is presented in this paper. After applying a novel approach to the AACMM kinematic parameter identification problem, by means of a single calibration gauge object, a one-step calibration method to obtain both intrinsic-laser plane, CCD sensor and camera geometry-and extrinsic parameters related to the AACMM main frame has been developed. This allows the integration of LTS and AACMM mathematical models without the need of additional optimization methods after the prior sensor calibration, usually done in a coordinate measuring machine (CMM) before the assembly of the sensor in the arm. The experimental tests results for accuracy and repeatability show the suitable performance of this technique, resulting in a reliable, quick and friendly calibration method for the AACMM final user. The presented method is also valid for sensor integration in robot arms and CMMs.

  20. A hybrid lightwave transmission system based on light injection/optoelectronic feedback techniques and fiber-VLLC integration

    NASA Astrophysics Data System (ADS)

    Tsai, Wen-Shing; Lu, Hai-Han; Li, Chung-Yi; Chen, Bo-Rui; Lin, Hung-Hsien; Lin, Dai-Hua

    2016-04-01

    A hybrid lightwave transmission system based on light injection/optoelectronic feedback techniques and fiber-visible laser light communication (VLLC) integration is proposed and experimentally demonstrated. To be the first one of its kind in employing light injection and optoelectronic feedback techniques in a fiber-VLLC integration lightwave transmission system, the light is successfully directly modulated with Community Access Television (CATV), 16-QAM, and 16-QAM-OFDM signals. Over a 40 km SMF and a 10 m free-space VLLC transport, good performances of carrier-to-noise ratio (CNR)/composite second-order (CSO)/composite triple-beat (CTB)/bit error rate (BER) are achieved for CATV/16-QAM/16-QAM-OFDM signals transmission. Such a hybrid lightwave transmission system would be very useful since it can provide broadband integrated services including CATV, Internet, and telecommunication services over both distribute fiber and in-building networks.

  1. Modelling and calibration technique of laser triangulation sensors for integration in robot arms and articulated arm coordinate measuring machines.

    PubMed

    Santolaria, Jorge; Guillomía, David; Cajal, Carlos; Albajez, José A; Aguilar, Juan J

    2009-01-01

    A technique for intrinsic and extrinsic calibration of a laser triangulation sensor (LTS) integrated in an articulated arm coordinate measuring machine (AACMM) is presented in this paper. After applying a novel approach to the AACMM kinematic parameter identification problem, by means of a single calibration gauge object, a one-step calibration method to obtain both intrinsic-laser plane, CCD sensor and camera geometry-and extrinsic parameters related to the AACMM main frame has been developed. This allows the integration of LTS and AACMM mathematical models without the need of additional optimization methods after the prior sensor calibration, usually done in a coordinate measuring machine (CMM) before the assembly of the sensor in the arm. The experimental tests results for accuracy and repeatability show the suitable performance of this technique, resulting in a reliable, quick and friendly calibration method for the AACMM final user. The presented method is also valid for sensor integration in robot arms and CMMs. PMID:22400001

  2. Modelling and Calibration Technique of Laser Triangulation Sensors for Integration in Robot Arms and Articulated Arm Coordinate Measuring Machines

    PubMed Central

    Santolaria, Jorge; Guillomía, David; Cajal, Carlos; Albajez, José A.; Aguilar, Juan J.

    2009-01-01

    A technique for intrinsic and extrinsic calibration of a laser triangulation sensor (LTS) integrated in an articulated arm coordinate measuring machine (AACMM) is presented in this paper. After applying a novel approach to the AACMM kinematic parameter identification problem, by means of a single calibration gauge object, a one-step calibration method to obtain both intrinsic—laser plane, CCD sensor and camera geometry—and extrinsic parameters related to the AACMM main frame has been developed. This allows the integration of LTS and AACMM mathematical models without the need of additional optimization methods after the prior sensor calibration, usually done in a coordinate measuring machine (CMM) before the assembly of the sensor in the arm. The experimental tests results for accuracy and repeatability show the suitable performance of this technique, resulting in a reliable, quick and friendly calibration method for the AACMM final user. The presented method is also valid for sensor integration in robot arms and CMMs. PMID:22400001

  3. Technique for the integral casting of pressure instrumentation in wind-tunnel models

    NASA Technical Reports Server (NTRS)

    Jackson, C. M., Jr.; Summerfield, D. G.

    1971-01-01

    Wind tunnel models are cast around core consisting of array of tubing. Principal advantage of technique is that greater number of pressure orifices are easily installed, without compromising aerodynamic shape of model. Technique reduces construction cost by about 50 percent.

  4. The area-time-integral technique to estimate convective rain volumes over areas applied to satellite data - A preliminary investigation

    NASA Technical Reports Server (NTRS)

    Doneaud, Andre A.; Miller, James R., Jr.; Johnson, L. Ronald; Vonder Haar, Thomas H.; Laybe, Patrick

    1987-01-01

    The use of the area-time-integral (ATI) technique, based only on satellite data, to estimate convective rain volume over a moving target is examined. The technique is based on the correlation between the radar echo area coverage integrated over the lifetime of the storm and the radar estimated rain volume. The processing of the GOES and radar data collected in 1981 is described. The radar and satellite parameters for six convective clusters from storm events occurring on June 12 and July 2, 1981 are analyzed and compared in terms of time steps and cluster lifetimes. Rain volume is calculated by first using the regression analysis to generate the regression equation used to obtain the ATI; the ATI versus rain volume relation is then employed to compute rain volume. The data reveal that the ATI technique using satellite data is applicable to the calculation of rain volume.

  5. A 300 mV sub-threshold region 2.4 GHz voltage-controlled oscillator and frequency divider with transformer technique for ultralow power RF applications

    NASA Astrophysics Data System (ADS)

    Miyahara, Yasunori; Ishikawa, Keisuke; Kuroda, Tadahiro

    2014-01-01

    A new ultralow voltage 2.4 GHz voltage-controlled oscillator (VCO) and a divide-by-2 frequency divider circuits operating in a CMOS sub-threshold region using a transformer technique have been developed. In the sub-threshold region, the CMOS transistor high frequency performances are decreased to the point where oscillation and frequency division are challenging to achieve. The new proposed VCO uses the transformer feedback complementary VCO technique to improves VCO negative feedback gain. The circuits have been fabricated in a 65 nm standard CMOS process. The oscillation frequency is designed at 2.4 GHz under a 300 mV supply voltage. The total power consumption is 202 µW with noise performance of -96 dBc/Hz at 1 MHz offset. The new proposed frequency divider circuit consists of two stages master-slave D-type flip-flop (DFF). The DFF differential input is coupled to a transformer circuit instead of transistors to reduce the number of stacks. The minimum operating supply voltage is 300 mV with power consumption of 34 µW with a free-run frequency of 1.085 GHz.

  6. Selecting an Appropriate Multiple Comparison Technique: An Integration of Monte Carlo Studies.

    ERIC Educational Resources Information Center

    Myette, Beverly M.; White, Karl R.

    Twenty Monte Carlo studies on multiple comparison (MC) techniques were conducted to examine which MC technique was the "method of choice." The results from these studies had several apparent contradictions when different techniques were investigated under varying sample size and variance conditions. Box's coefficient of variance variation and bias…

  7. Integration of infrared and optical imaging techniques for the nondestructive inspection of aeronautic parts

    NASA Astrophysics Data System (ADS)

    López, F.; Sfarra, S.; Ibarra-Castanedo, C.; Paoletti, D.; Maldague, X.

    2015-05-01

    This work focuses in the implementation of infrared and optical imaging techniques for the inspection of aeronautics parts. To this aim, a helicopter blade with known defects is inspected with four different techniques: long pulse thermography, pulsed thermography, digital speckle photography (DSP) and holographic interferometry (HI). The first two techniques belongs to the group of infrared imaging techniques, which are based on the analysis of the infrared thermal patterns in order to detect internal anomalies in the material; whilst the last two (DSP and HI) corresponds to the optical imaging techniques which make use of visible light to measure the material response to an applied stress. Both techniques were applied using the active approach, i.e. an external stimulation is applied in order to produce a gradient in either, the thermal and/or displacement field of the material. The results are then compared in order to evaluate the advantages and limitations of each technique.

  8. Evaluation of oxide layers formed during the decarburisation of grain-oriented electrical steel using a Fourier transform infrared (FTIR) technique

    NASA Astrophysics Data System (ADS)

    Poultney, Darren; Snell, David

    Electrical steels are highly specialised, magnetically soft materials, used to form the cores that carry the magnetic flux in electrical machines such as motors, generators and transformers. During the production of GO electrical steel, the strip passes through a decarburisation furnace, which promotes the formation of a thin surface oxide layer consisting of predominantly fayalite (Fe 2SiO 4) and silica (SiO 2). During a subsequent high temperature anneal, this layer reacts with magnesia (MgO) to form a forsterite 'glass film' layer, which applies a tensile stress to the steel. This reduces the magnetic losses of the material on which the final product is routinely graded. Due to the effect that the oxide layer has on the quality of the final material, it would be beneficial to possess a technique that can rapidly assess its composition and/or morphology. This paper details the assessment of Fourier transform infrared (FTIR) and electrochemical potential (ECP) analysis, and a technique of combining the two. FTIR analysis of the decarburisation oxide layer exhibited evidence of just fayalite, with silica only being observed on the spectra following brief acid etching. To refine the etching process, samples were removed from the acid at various intervals based on the output of the ECP technique. It was established that there was a clear link between the position reached on the ECP profile and absorption bands observed on the corresponding FTIR spectra.

  9. A computerized symbolic integration technique for development of triangular and quadrilateral composite shallow-shell finite elements

    NASA Technical Reports Server (NTRS)

    Anderson, C. M.; Noor, A. K.

    1975-01-01

    Computerized symbolic integration was used in conjunction with group-theoretic techniques to obtain analytic expressions for the stiffness, geometric stiffness, consistent mass, and consistent load matrices of composite shallow shell structural elements. The elements are shear flexible and have variable curvature. A stiffness (displacement) formulation was used with the fundamental unknowns consisting of both the displacement and rotation components of the reference surface of the shell. The triangular elements have six and ten nodes; the quadrilateral elements have four and eight nodes and can have internal degrees of freedom associated with displacement modes which vanish along the edges of the element (bubble modes). The stiffness, geometric stiffness, consistent mass, and consistent load coefficients are expressed as linear combinations of integrals (over the element domain) whose integrands are products of shape functions and their derivatives. The evaluation of the elemental matrices is divided into two separate problems - determination of the coefficients in the linear combination and evaluation of the integrals. The integrals are performed symbolically by using the symbolic-and-algebraic-manipulation language MACSYMA. The efficiency of using symbolic integration in the element development is demonstrated by comparing the number of floating-point arithmetic operations required in this approach with those required by a commonly used numerical quadrature technique.

  10. An Innovative Technique for Evaluating the Integrity and Durability of Wind Turbine Blade Composites

    SciTech Connect

    Wang, Jy-An John; Ren, Fei

    2010-09-01

    Wind turbine blades are subjected to complex multiaxial stress states during operation. A review of the literature suggests that mixed mode fracture toughness can be significantly less than that of the tensile opening mode (Mode I), implying that fracture failure can occur at a much lower load capacity if the structure is subject to mixed-mode loading. Thus, it will be necessary to identify the mechanisms that might lead to failure in blade materials under mixed-mode loading conditions. Meanwhile, wind turbine blades are typically fabricated from fiber reinforced polymeric materials, e.g. fiber glass composites. Due to the large degree of anisotropy in mechanical properties that is usually associated with laminates, the fracture behavior of these composite materials is likely to be strongly dependent on the loading conditions. This may further strengthen the need to study the effect of mixed-mode loading on the integrity and durability of the wind turbine blade composites. To quantify the fracture behavior of composite structures under mixed mode loading conditions, particularly under combined Mode I (flexural or normal tensile stress) and Mode III (torsional shear stress) loading, a new testing technique is proposed based on the spiral notch torsion test (SNTT). As a 2002 R&D 100 Award winner, SNTT is a novel fracture testing technology. SNTT has many advantages over conventional fracture toughness methods and has been used to determine fracture toughness values on a wide spectrum of materials. The current project is the first attempt to utilize SNTT on polymeric and polymer-based composite materials. It is expected that mixed-mode failure mechanisms of wind turbine blades induced by typical in-service loading conditions, such as delamination, matrix cracking, fiber pull-out and fracture, can be effectively and economically investigated by using this methodology. This project consists of two phases. The Phase I (FY2010) effort includes (1) preparation of testing

  11. Integration of the simian virus 40 genome into cellular DNA in temperature-sensitive (N) and temperature-insensitive (A) transformants of 3T3 rat and Chinese hamster lung cells.

    PubMed Central

    Chepelinsky, A B; Seif, R; Martin, R G

    1980-01-01

    We studied the pattern of integration of the simian virus 40 (SV40) genome into the cellular DNA of N-transformants (temperature sensitive) and A-transformants (temperature insensitive) derived from 3T3-Fisher rat and Chinese hamster lung cells. The SV40 DNA was covalently linked to the cellular DNA in both types of transformants. In the rat cells, most N-transformants contained SV40 sequences integrated at a single site; most A-transformants contained SV40 sequences integrated at two to five sites. In the Chinese hamster cells, no significant correlation between the number of integration sites and the phenotype of the transformant was found; one of three integration sites were observed for both the N- and A-transformants. Single copies and tandem repeats of SV40 sequences were observed in A- and N-transformants derived from rat cells. A-transformants arise neither by amplification of the SV40 genome nor by integration at a unique site. Images PMID:6251267

  12. How is Shrimp Aquaculture Transforming Coastal Livelihoods and Lagoons in Estero Real, Nicaragua?: The Need to Integrate Social-Ecological Research and Ecosystem-Based Approaches

    NASA Astrophysics Data System (ADS)

    Benessaiah, Karina; Sengupta, Raja

    2014-08-01

    Ecosystem-based approaches to aquaculture integrate environmental concerns into planning. Social-ecological systems research can improve this approach by explicitly relating ecological and social dynamics of change at multiple scales. Doing so requires not only addressing direct effects of aquaculture but also considering indirect factors such as changes in livelihood strategies, governance dynamics, and power relations. We selected the community of Puerto Morazán, Nicaragua as a case study to demonstrate how the introduction of small-scale aquaculture radically transformed another key livelihood activity, lagoon shrimp fishing, and the effects that these changes have had on lagoons and the people that depend on them. We find that shrimp aquaculture played a key role in the collapse, in the 1990s, of an existing lagoon common-property management. Shrimp aquaculture-related capital enabled the adoption of a new fishing technique that not only degraded lagoons but also led to their gradual privatization. The existence of social ties between small-scale shrimp farmers and other community members mitigated the impacts of privatization, illustrating the importance of social capital. Since 2008, community members are seeking to communally manage the lagoons once again, in response to degraded environmental conditions and a consolidation of the shrimp industry at the expense of smaller actors. This research shows that shrimp aquaculture intersects with a complex set of drivers, affecting not only how ecosystems are managed but also how they are perceived and valued. Understanding these social-ecological dynamics is essential to implement realistic policies and management of mangrove ecosystems and address the needs of resource-dependent people.

  13. How is shrimp aquaculture transforming coastal livelihoods and lagoons in Estero Real, Nicaragua? The need to integrate social-ecological research and ecosystem-based approaches.

    PubMed

    Benessaiah, Karina; Sengupta, Raja

    2014-08-01

    Ecosystem-based approaches to aquaculture integrate environmental concerns into planning. Social-ecological systems research can improve this approach by explicitly relating ecological and social dynamics of change at multiple scales. Doing so requires not only addressing direct effects of aquaculture but also considering indirect factors such as changes in livelihood strategies, governance dynamics, and power relations. We selected the community of Puerto Morazán, Nicaragua as a case study to demonstrate how the introduction of small-scale aquaculture radically transformed another key livelihood activity, lagoon shrimp fishing, and the effects that these changes have had on lagoons and the people that depend on them. We find that shrimp aquaculture played a key role in the collapse, in the 1990s, of an existing lagoon common-property management. Shrimp aquaculture-related capital enabled the adoption of a new fishing technique that not only degraded lagoons but also led to their gradual privatization. The existence of social ties between small-scale shrimp farmers and other community members mitigated the impacts of privatization, illustrating the importance of social capital. Since 2008, community members are seeking to communally manage the lagoons once again, in response to degraded environmental conditions and a consolidation of the shrimp industry at the expense of smaller actors. This research shows that shrimp aquaculture intersects with a complex set of drivers, affecting not only how ecosystems are managed but also how they are perceived and valued. Understanding these social-ecological dynamics is essential to implement realistic policies and management of mangrove ecosystems and address the needs of resource-dependent people.

  14. An Integrated Approach to Change the Outcome Part II: Targeted Neuromuscular Training Techniques to Reduce Identified ACL Injury Risk Factors

    PubMed Central

    Myer, Gregory D.; Ford, Kevin R.; Brent, Jensen L.; Hewett, Timothy E.

    2014-01-01

    Prior reports indicate that female athletes who demonstrate high knee abduction moments (KAMs) during landing are more responsive to neuromuscular training designed to reduce KAM. Identification of female athletes who demonstrate high KAM, which accurately identifies those at risk for noncontact anterior cruciate ligament (ACL) injury, may be ideal for targeted neuromuscular training. Specific neuromuscular training targeted to the underlying biomechanical components that increase KAM may provide the most efficient and effective training strategy to reduce noncontact ACL injury risk. The purpose of the current commentary is to provide an integrative approach to identify and target mechanistic underpinnings to increased ACL injury in female athletes. Specific neuromuscular training techniques will be presented that address individual algorithm components related to high knee load landing patterns. If these integrated techniques are employed on a widespread basis, prevention strategies for noncontact ACL injury among young female athletes may prove both more effective and efficient. PMID:22580980

  15. A Gas Dynamics Method Based on The Spectral Deferred Corrections (SDC) Time Integration Technique and The Piecewise Parabolic Method (PPM)

    SciTech Connect

    Samet Y. Kadioglu

    2011-12-01

    We present a computational gas dynamics method based on the Spectral Deferred Corrections (SDC) time integration technique and the Piecewise Parabolic Method (PPM) finite volume method. The PPM framework is used to define edge averaged quantities which are then used to evaluate numerical flux functions. The SDC technique is used to integrate solution in time. This kind of approach was first taken by Anita et al in [17]. However, [17] is problematic when it is implemented to certain shock problems. Here we propose significant improvements to [17]. The method is fourth order (both in space and time) for smooth flows, and provides highly resolved discontinuous solutions. We tested the method by solving variety of problems. Results indicate that the fourth order of accuracy in both space and time has been achieved when the flow is smooth. Results also demonstrate the shock capturing ability of the method.

  16. Fourier transform-infrared spectroscopy and Gas chromatography-mass spectroscopy: reliable techniques for analysis of Parthenium mediated vermicompost.

    PubMed

    Rajiv, P; Rajeshwari, Sivaraj; Venckatesh, Rajendran

    2013-12-01

    Fourier transform infrared spectroscopy (FT-IR) and Gas chromatography-mass spectroscopy have been carried out to investigate the chemical composition of Parthenium mediated vermicompost. Four different concentrations of Parthenium and cow dung mixtures were vermicomposted using the earthworms (Eudrilus eugeniae). FT-IR spectra reveal the absence of Parthenin toxin (sesquiterpene lactone) and phenols in vermicompost which was obtained from high concentration of cow dung mixed treatments. GC-MS analysis shows no phenolic compounds and predominant level of intermediate metabolites such as 4,8,12,16-Tetramethylheptadecan-4-olide (7.61%), 2-Pentadecanone, 6,10,14-trimethyl- (5.29%) and Methyl 16-methyl-heptadecanoate (4.69%) during the vermicomposting process. Spectral results indicated that Parthenin toxin and phenols can be eradicated via vermicomposting if mixed with appropriate quantity of cow dung.

  17. Fourier transform-infrared spectroscopy and Gas chromatography-mass spectroscopy: Reliable techniques for analysis of Parthenium mediated vermicompost

    NASA Astrophysics Data System (ADS)

    Rajiv, P.; Rajeshwari, Sivaraj; Venckatesh, Rajendran

    2013-12-01

    Fourier transform infrared spectroscopy (FT-IR) and Gas chromatography-mass spectroscopy have been carried out to investigate the chemical composition of Parthenium mediated vermicompost. Four different concentrations of Parthenium and cow dung mixtures were vermicomposted using the earthworms (Eudrilus eugeniae). FT-IR spectra reveal the absence of Parthenin toxin (sesquiterpene lactone) and phenols in vermicompost which was obtained from high concentration of cow dung mixed treatments. GC-MS analysis shows no phenolic compounds and predominant level of intermediate metabolites such as 4,8,12,16-Tetramethylheptadecan-4-olide (7.61%), 2-Pentadecanone, 6,10,14-trimethyl- (5.29%) and Methyl 16-methyl-heptadecanoate (4.69%) during the vermicomposting process. Spectral results indicated that Parthenin toxin and phenols can be eradicated via vermicomposting if mixed with appropriate quantity of cow dung.

  18. SnO2-MOF-Fabry-Perot humidity optical sensor system based on fast Fourier transform technique

    NASA Astrophysics Data System (ADS)

    Lopez-Aldaba, A.; Lopez-Torres, D.; Ascorbe, J.; Rota-Rodrigo, S.; Elosua, C.; Lopez-Amo, M.; Arregui, F. J.; Corres, J. M.; Auguste, J.-L.; Jamier, R.; Roy, P.

    2016-05-01

    In this paper, a new sensor system for relative humidity measurements based on a SnO2 sputtering deposition on a microstructured optical fiber (MOF) low-finesse Fabry-Perot (FP) sensing head is presented and characterized. The interrogation of the sensing head is carried out by monitoring the Fast Fourier Transform phase variations of the FP interference frequency. This method is low-sensitive to signal amplitude variations and also avoids the necessity of tracking the evolution of peaks and valleys in the spectrum. The sensor is operated within a wide humidity range (20%-90% relative humidity) with a maximum sensitivity achieved of 0.14rad/%. The measurement method uses a commercial optical interrogator as the only active element, this compact solution allows real time analysis of the data.

  19. Generation of 238U Covariance Matrices by Using the Integral Data Assimilation Technique of the CONRAD Code

    NASA Astrophysics Data System (ADS)

    Privas, E.; Archier, P.; Bernard, D.; De Saint Jean, C.; Destouche, C.; Leconte, P.; Noguère, G.; Peneliau, Y.; Capote, R.

    2016-02-01

    A new IAEA Coordinated Research Project (CRP) aims to test, validate and improve the IRDF library. Among the isotopes of interest, the modelisation of the 238U capture and fission cross sections represents a challenging task. A new description of the 238U neutrons induced reactions in the fast energy range is within progress in the frame of an IAEA evaluation consortium. The Nuclear Data group of Cadarache participates in this effort utilizing the 238U spectral indices measurements and Post Irradiated Experiments (PIE) carried out in the fast reactors MASURCA (CEA Cadarache) and PHENIX (CEA Marcoule). Such a collection of experimental results provides reliable integral information on the (n,γ) and (n,f) cross sections. This paper presents the Integral Data Assimilation (IDA) technique of the CONRAD code used to propagate the uncertainties of the integral data on the 238U cross sections of interest for dosimetry applications.

  20. Assessment of liver steatosis and fibrosis in rats using integrated coherent anti-Stokes Raman scattering and multiphoton imaging technique

    NASA Astrophysics Data System (ADS)

    Lin, Jian; Lu, Fake; Zheng, Wei; Xu, Shuoyu; Tai, Dean; Yu, Hanry; Huang, Zhiwei

    2011-11-01

    We report the implementation of a unique integrated coherent anti-Stokes Raman scattering (CARS), second-harmonic generation (SHG), and two-photon excitation fluorescence (TPEF) microscopy imaging technique developed for label-free monitoring of the progression of liver steatosis and fibrosis generated in a bile duct ligation (BDL) rat model. Among the 21 adult rats used in this study, 18 rats were performed with BDL surgery and sacrificed each week from weeks 1 to 6 (n = 3 per week), respectively; whereas 3 rats as control were sacrificed at week 0. Colocalized imaging of the aggregated hepatic fats, collagen fibrils, and hepatocyte morphologies in liver tissue is realized by using the integrated CARS, SHG, and TPEF technique. The results show that there are significant accumulations of hepatic lipid droplets and collagen fibrils associated with severe hepatocyte necrosis in BDL rat liver as compared to a normal liver tissue. The volume of normal hepatocytes keeps decreasing and the fiber collagen content in BDL rat liver follows a growing trend until week 6; whereas the hepatic fat content reaches a maximum in week 4 and then appears to stop growing in week 6, indicating that liver steatosis and fibrosis induced in a BDL rat liver model may develop at different rates. This work demonstrates that the integrated CARS and multiphoton microscopy imaging technique has the potential to provide an effective means for early diagnosis and detection of liver steatosis and fibrosis without labeling.

  1. Path integral molecular dynamics within the grand canonical-like adaptive resolution technique: Simulation of liquid water

    SciTech Connect

    Agarwal, Animesh Delle Site, Luigi

    2015-09-07

    Quantum effects due to the spatial delocalization of light atoms are treated in molecular simulation via the path integral technique. Among several methods, Path Integral (PI) Molecular Dynamics (MD) is nowadays a powerful tool to investigate properties induced by spatial delocalization of atoms; however, computationally this technique is very demanding. The above mentioned limitation implies the restriction of PIMD applications to relatively small systems and short time scales. One of the possible solutions to overcome size and time limitation is to introduce PIMD algorithms into the Adaptive Resolution Simulation Scheme (AdResS). AdResS requires a relatively small region treated at path integral level and embeds it into a large molecular reservoir consisting of generic spherical coarse grained molecules. It was previously shown that the realization of the idea above, at a simple level, produced reasonable results for toy systems or simple/test systems like liquid parahydrogen. Encouraged by previous results, in this paper, we show the simulation of liquid water at room conditions where AdResS, in its latest and more accurate Grand-Canonical-like version (GC-AdResS), is merged with two of the most relevant PIMD techniques available in the literature. The comparison of our results with those reported in the literature and/or with those obtained from full PIMD simulations shows a highly satisfactory agreement.

  2. An integrated study of earth resources in the state of California using remote sensing techniques

    NASA Technical Reports Server (NTRS)

    1973-01-01

    University of California investigations to determine the usefulness of modern remote sensing techniques have concentrated on the water resources of the state. The studies consider in detail the supply, demand, and impact relationships.

  3. Integrating Milton H. Erickson's Hypnotherapeutic Techniques into General Counseling and Psychotherapy.

    ERIC Educational Resources Information Center

    Otani, Akira

    1989-01-01

    Examines several basic hypnotherapeutic techniques (rapport building, problem assessment, resistance management, and behavior change) based on Milton H. Erickson's hypnotherapeutic principles that can be translated into the general framework of counseling. (Author/CM)

  4. Use of the Fourier transform infrared (FTIR) technique for determination of the composition of final phosphate coatings on grain-oriented electrical steel

    NASA Astrophysics Data System (ADS)

    Poultney, Darren; Snell, David

    Electrical steels are highly specialised, magnetically soft materials, used to form the cores that carry the magnetic flux in electrical machines such as motors, generators and transformers. The steel strip is coated with a phosphate-based solution, which, on curing, provides an electrically insulating layer that also imparts a tension onto the strip. It has previously been shown that the magnetic losses of the material are affected by the ratio of phosphate and silica within the coating solution [O. Tanaka, H. Kobayashi, E. Minematsu, New insulating coating for grain-oriented electrical steel, J. Mater. Eng. 13 (1991) 161-168.]. It would therefore be highly beneficial to possess an analytical technique that can be used to accurately and rapidly determine the composition of this coating. This paper details the evaluation of the Fourier transform infrared (FTIR) technique for this purpose. Analysing each of the important constituents separately enabled their specific absorption bands to be identified, and laboratory trials produced spectra that exhibited a good agreement with theoretical predictions. Analysis of samples coated under production conditions was found to be more challenging due to the detection of an underlying forsterite layer. However, there is potential for FTIR analysis when using regions of the spectra that were unaffected by this compound.

  5. A PAPR reduction technique using Hadamard transform combined with clipping and filtering based on DCT/IDCT for IM/DD optical OFDM systems

    NASA Astrophysics Data System (ADS)

    Mangone, Fall; He, Jing; Tang, Jin; Xiao, Jiangnan; Chen, Ming; Li, Fan; Chen, Lin

    2014-08-01

    In Intensity Modulator/Direct Detection (IM/DD) optical OFDM systems, the high peak-to-power average ratio (PAPR) will cause signal impairments through the nonlinearity of modulator and fiber. In this paper, a joint PAPR reduction technique based on Hadamard transformation and clipping and filtering using DCT/IDCT transform has been proposed for mitigating the impairments in IM/DD optical OFDM system. We then experimentally evaluated the effect of PAPR reduction on the bit error rate (BER) performance and the results show the effectiveness of the proposed technique. At a bit error rate (BER) of 1 × 10-3, the receiver sensitivity of the proposed 2.5 Gb/s IM/DD optical OFDM system after 100-km standard single-mode fiber transmission has been improved by 0.8 dB, 1.3 dB and 3.1 dB for a launch power of 6.4 dBm, 8 dBm and 10 dBm respectively when compared with the classical system.

  6. Light absorption by airborne aerosols: comparison of integrating plate and spectrophone techniques.

    PubMed

    Szkarlat, A C; Japar, S M

    1981-04-01

    An excellent correlation between the integrating plate (IP) and the photoacoustic methods for measuring aerosol light absorption has been found for airborne graphitic carbon in diesel vehicle exhaust. However, the regression coefficient depends on the orientation of the Teflon membrane filter during the IP analysis. With the collected particulates between the filter and the integrating plate, the IP response is 1.85 times that for the filter reversed. In either case the response ratio of the IP method to the photoacoustic method is >1.0, i.e., 2.43 vs 1.30. The IP calibration is also probably dependent on the nature of the filter medium. PMID:20309278

  7. Assessment of nitrous oxide emission from cement plants: real data measured with both Fourier transform infrared and nondispersive infrared techniques.

    PubMed

    Mosca, Silvia; Benedetti, Paolo; Guerriero, Ettore; Rotatori, Mauro

    2014-11-01

    Nitrous oxide (N2O) is the third most important greenhouse gas after carbon dioxide and methane, and contributes about 6% to the greenhouse effect. Nitrous oxide is a minor component of the atmosphere, and it is a thousand times less than carbon dioxide (CO2). Nevertheless, it is much more potent than CO2 and methane, owing to its long stay in the atmosphere of approximately 120 yr and the high global warmingpotential (GWP) of298 times that of CO2. Although greenhouse gases are natural in the atmosphere, human activities have changed the atmospheric concentrations. Most of the values of emission of nitrous oxide are still obtained by means ofemission factors and not actually measured; the lack ofreal data may result in an underestimation ofcurrent emissions. The emission factors used for the calculation of N2O can be obtained from the "Guidelines for the implementation of the national inventory of emissions" of the Intergovernmental Panel on Climate Change, which refer to all nations for the realization of their inventory. This study will present real data, measured in several Italian cement plants with different characteristics. The work also shows a comparison between N2O concentration measured with in situ-Fourier transform IR (FTIR) and the reference method EN ISO 21258 based on nondispersive IR (NDIR), in order to investigate the interfering compounds in the measurement with NDIR.

  8. Assessment of nitrous oxide emission from cement plants: real data measured with both Fourier transform infrared and nondispersive infrared techniques.

    PubMed

    Mosca, Silvia; Benedetti, Paolo; Guerriero, Ettore; Rotatori, Mauro

    2014-11-01

    Nitrous oxide (N2O) is the third most important greenhouse gas after carbon dioxide and methane, and contributes about 6% to the greenhouse effect. Nitrous oxide is a minor component of the atmosphere, and it is a thousand times less than carbon dioxide (CO2). Nevertheless, it is much more potent than CO2 and methane, owing to its long stay in the atmosphere of approximately 120 yr and the high global warmingpotential (GWP) of298 times that of CO2. Although greenhouse gases are natural in the atmosphere, human activities have changed the atmospheric concentrations. Most of the values of emission of nitrous oxide are still obtained by means ofemission factors and not actually measured; the lack ofreal data may result in an underestimation ofcurrent emissions. The emission factors used for the calculation of N2O can be obtained from the "Guidelines for the implementation of the national inventory of emissions" of the Intergovernmental Panel on Climate Change, which refer to all nations for the realization of their inventory. This study will present real data, measured in several Italian cement plants with different characteristics. The work also shows a comparison between N2O concentration measured with in situ-Fourier transform IR (FTIR) and the reference method EN ISO 21258 based on nondispersive IR (NDIR), in order to investigate the interfering compounds in the measurement with NDIR. PMID:25509548

  9. Non-invertible transformations of differential–difference equations

    NASA Astrophysics Data System (ADS)

    Garifullin, R. N.; Yamilov, R. I.; Levi, D.

    2016-09-01

    We discuss aspects of the theory of non-invertible transformations of differential–difference equations and, in particular, the notion of Miura type transformation. We introduce the concept of non-Miura type linearizable transformation and we present techniques that allow one to construct simple linearizable transformations and might help one to solve classification problems. This theory is illustrated by the example of a new integrable differential–difference equation depending on five lattice points, interesting from the viewpoint of the non-invertible transformation, which relate it to an Itoh–Narita–Bogoyavlensky equation.

  10. Monitoring of Land Subsidence in Ravenna Municipality Using Integrated SAR - GPS Techniques: Description and First Results

    NASA Astrophysics Data System (ADS)

    Artese, G.; Fiaschi, S.; Di Martire, D.; Tessitore, S.; Fabris, M.; Achilli, V.; Ahmed, A.; Borgstrom, S.; Calcaterra, D.; Ramondini, M.; Artese, S.; Floris, M.; Menin, A.; Monego, M.; Siniscalchi, V.

    2016-06-01

    The Emilia Romagna Region (N-E Italy) and in particular the Adriatic Sea coastline of Ravenna, is affected by a noticeable subsidence that started in the 1950s, when the exploitation of on and off-shore methane reservoirs began, along with the pumping of groundwater for industrial uses. In such area the current subsidence rate, even if lower than in the past, reaches the -2 cm/y. Over the years, local Authorities have monitored this phenomenon with different techniques: spirit levelling, GPS surveys and, more recently, Differential Interferometric Synthetic Aperture Radar (DInSAR) techniques, confirming the critical situation of land subsidence risk. In this work, we present the comparison between the results obtained with DInSAR and GPS techniques applied to the study of the land subsidence in the Ravenna territory. With regard to the DInSAR, the Small Baseline Subset (SBAS) and the Coherent Pixel Technique (CPT) techniques have been used. Different SAR datasets have been exploited: ERS-1/2, ENVISAT, TerraSAR-X and Sentinel-1. Some GPS campaigns have been also carried out in a subsidence prone area. 3D vertices have been selected very close to existing persistent scatterers in order to link the GPS measurement results to the SAR ones. GPS data were processed into the International reference system and the comparisons between the coordinates, for the first 6 months of the monitoring, provided results with the same trend of the DInSAR data, even if inside the precision of the method.

  11. Integrating new data balancing technique with committee networks for imbalanced data: GRSOM approach.

    PubMed

    Chetchotsak, Danaipong; Pattanapairoj, Sirorat; Arnonkijpanich, Banchar

    2015-12-01

    To deal with imbalanced data in a classification problem, this paper proposes a data balancing technique to be used in conjunction with a committee network. The proposed data balancing technique is based on the concept of the growing ring self-organizing map (GRSOM) which is an unsupervised learning algorithm. GRSOM balances the data through growing new data on a well-defined ring structure, which is iteratively developed based on the winning node nearby the samples. Accordingly, the new balanced data still preserve the topology of the original data. The performance of our proposed method is evaluated using four real data sets from the UCI Machine Learning Repository and the classification performance is measured using the fivefold cross validation method. Classifiers with most common data balancing techniques, namely the Minority Over-Sampling Technique (SMOTE) and the Random under-sampling Technique (RT), are used as the baseline methods in this study. The results reveal that a committee of classifiers constructed using GRSOM performs at least as well as the baseline methods. The results also suggest that classifiers constructed using neural networks with the backpropagation algorithm are more robust than those using the support vector machine.

  12. Techniques and Measurements. Seychelles Integrated Science. [Teacher and Pupil Booklets]. Unit 1.

    ERIC Educational Resources Information Center

    Brophy, M.; Fryars, M.

    Seychelles Integrated Science (SIS), a 3-year laboratory-based science program for students (ages 11-15) in upper primary grades 7, 8, and 9, was developed from an extensive evaluation and modification of previous P7-P9 materials. This P7 SIS unit is designed to: (1) introduce students to and familiarize them with working in the school laboratory;…

  13. Clean assembly and integration techniques for the Hubble Space Telescope High Fidelity Mechanical Simulator

    NASA Technical Reports Server (NTRS)

    Hughes, David W.; Hedgeland, Randy J.

    1994-01-01

    A mechanical simulator of the Hubble Space Telescope (HST) Aft Shroud was built to perform verification testing of the Servicing Mission Scientific Instruments (SI's) and to provide a facility for astronaut training. All assembly, integration, and test activities occurred under the guidance of a contamination control plan, and all work was reviewed by a contamination engineer prior to implementation. An integrated approach was followed in which materials selection, manufacturing, assembly, subsystem integration, and end product use were considered and controlled to ensure that the use of the High Fidelity Mechanical Simulator (HFMS) as a verification tool would not contaminate mission critical hardware. Surfaces were cleaned throughout manufacturing, assembly, and integration, and reverification was performed following major activities. Direct surface sampling was the preferred method of verification, but access and material constraints led to the use of indirect methods as well. Although surface geometries and coatings often made contamination verification difficult, final contamination sampling and monitoring demonstrated the ability to maintain a class M5.5 environment with surface levels less than 400B inside the HFMS.

  14. Comparison of numerical techniques for integration of stiff ordinary differential equations arising in combustion chemistry

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, K.

    1984-01-01

    The efficiency and accuracy of several algorithms recently developed for the efficient numerical integration of stiff ordinary differential equations are compared. The methods examined include two general-purpose codes, EPISODE and LSODE, and three codes (CHEMEQ, CREK1D, and GCKP84) developed specifically to integrate chemical kinetic rate equations. The codes are applied to two test problems drawn from combustion kinetics. The comparisons show that LSODE is the fastest code currently available for the integration of combustion kinetic rate equations. An important finding is that an interactive solution of the algebraic energy conservation equation to compute the temperature does not result in significant errors. In addition, this method is more efficient than evaluating the temperature by integrating its time derivative. Significant reductions in computational work are realized by updating the rate constants (k = at(supra N) N exp(-E/RT) only when the temperature change exceeds an amount delta T that is problem dependent. An approximate expression for the automatic evaluation of delta T is derived and is shown to result in increased efficiency.

  15. Integration of an organic photodetector onto a plastic optical fiber by means of spray coating technique.

    PubMed

    Binda, Maddalena; Natali, Dario; Iacchetti, Antonio; Sampietro, Marco

    2013-08-21

    A working prototype of integrated fiber/receiver system for optical data transmission is realized. The prototype is made by directly depositing an organic photodetector onto a plastic optical fiber. For the deposition of the organic layers, spray coating is successfully exploited. Operation over four orders of magnitude range of light intensities as well as photoresponse to pulsed stimulation are demonstrated.

  16. Variance reduction techniques for estimation of integrals over a set of branching trajectories

    NASA Astrophysics Data System (ADS)

    Tsvetkov, E. A.

    2014-02-01

    Monte Carlo variance reduction techniques within the supertrack approach are justified as applied to estimating non-Boltzmann tallies equal to the mean of a random variable defined on the set of all branching trajectories. For this purpose, a probability space is constructed on the set of all branching trajectories, and the unbiasedness of this method is proved by averaging over all trajectories. Variance reduction techniques, such as importance sampling, splitting, and Russian roulette, are discussed. A method is described for extending available codes based on the von Neumann-Ulam scheme in order to cover the supertrack approach.

  17. Integrating Family Counseling Theories and Techniques with Developmental Counseling and Therapy.

    ERIC Educational Resources Information Center

    Chang, Catherine Y.

    This paper summarizes Iveys Developmental Counseling and Therapy theory and includes practical applications of theory, discusses the general concepts of family counseling theories and the family systems continuum, summarizes the central theoretical constructs and goals and practical therapeutic techniques of Systemic Cognitive-Developmental…

  18. The computer integrated documentation project: A merge of hypermedia and AI techniques

    NASA Technical Reports Server (NTRS)

    Mathe, Nathalie; Boy, Guy

    1993-01-01

    To generate intelligent indexing that allows context-sensitive information retrieval, a system must be able to acquire knowledge directly through interaction with users. In this paper, we present the architecture for CID (Computer Integrated Documentation). CID is a system that enables integration of various technical documents in a hypertext framework and includes an intelligent browsing system that incorporates indexing in context. CID's knowledge-based indexing mechanism allows case based knowledge acquisition by experimentation. It utilizes on-line user information requirements and suggestions either to reinforce current indexing in case of success or to generate new knowledge in case of failure. This allows CID's intelligent interface system to provide helpful responses, based on previous experience (user feedback). We describe CID's current capabilities and provide an overview of our plans for extending the system.

  19. Integrating remote sensing, geographic information systems and global positioning system techniques with hydrological modeling

    NASA Astrophysics Data System (ADS)

    Thakur, Jay Krishna; Singh, Sudhir Kumar; Ekanthalu, Vicky Shettigondahalli

    2016-03-01

    Integration of remote sensing (RS), geographic information systems (GIS) and global positioning system (GPS) are emerging research areas in the field of groundwater hydrology, resource management, environmental monitoring and during emergency response. Recent advancements in the fields of RS, GIS, GPS and higher level of computation will help in providing and handling a range of data simultaneously in a time- and cost-efficient manner. This review paper deals with hydrological modeling, uses of remote sensing and GIS in hydrological modeling, models of integrations and their need and in last the conclusion. After dealing with these issues conceptually and technically, we can develop better methods and novel approaches to handle large data sets and in a better way to communicate information related with rapidly decreasing societal resources, i.e. groundwater.

  20. Development of an integrated remote monitoring technique and its application to para-stressing bridge system

    NASA Astrophysics Data System (ADS)

    Miyamoto, Ayaho; Motoshita, Minoru; Casas, Joan R.

    2013-12-01

    Bridge monitoring system via information technology is capable of providing more accurate knowledge of bridge performance characteristics than traditional strategies. This paper describes not only an integrated Internet monitoring system that consists of a stand-alone monitoring system (SMS) and a Web-based Internet monitoring system (IMS) for bridge maintenance but also its application to para-stressing bridge system as an intelligent structure. IMS, as a Web-based system, is capable of addressing the remote monitoring by introducing measuring information derived from SMS into the system through Internet or intranet connected by either PHS or LAN. Moreover, the key functions of IMS such as data management system, condition assessment, and decision making with the proposed system are also introduced in this paper. Another goal of this study is to establish the framework of a para-stressing bridge system which is an intelligent bridge by integrating the bridge monitoring information into the system to control the bridge performance automatically.

  1. A hybrid electron and photon IMRT planning technique that lowers normal tissue integral patient dose using standard hardware

    SciTech Connect

    Rosca, Florin

    2012-06-15

    Purpose: To present a mixed electron and photon IMRT planning technique using electron beams with an energy range of 6-22 MeV and standard hardware that minimizes integral dose to patients for targets as deep as 7.5 cm. Methods: Ten brain cases, two lung, a thyroid, an abdominal, and a parotid case were planned using two planning techniques: a photon-only IMRT (IMRT) versus a mixed modality treatment (E + IMRT) that includes an enface electron beam and a photon IMRT portion that ensures a uniform target coverage. The electron beam is delivered using a regular cutout placed in an electron cone. The electron energy was chosen to provide a good trade-off between minimizing integral dose and generating a uniform, deliverable plan. The authors choose electron energies that cover the deepest part of PTV with the 65%-70% isodose line. The normal tissue integral dose, the dose for ring structures around the PTV, and the volumes of the 75%, 50%, and 25% isosurfaces were used to compare the dose distributions generated by the two planning techniques. Results: The normal tissue integral dose was lowered by about 20% by the E + IMRT plans compared to the photon-only IMRT ones for most studied cases. With the exception of lungs, the dose reduction associated to the E + IMRT plans was more pronounced further away from the target. The average dose ratio delivered to the 0-2 cm and the 2-4 cm ring structures for brain patients for the two planning techniques were 89.6% and 70.8%, respectively. The enhanced dose sparing away from the target for the brain patients can also be observed in the ratio of the 75%, 50%, and 25% isodose line volumes for the two techniques, which decreases from 85.5% to 72.6% and further to 65.1%, respectively. For lungs, the lateral electron beams used in the E + IMRT plans were perpendicular to the mostly anterior/posterior photon beams, generating much more conformal plans. Conclusions: The authors proved that even using the existing electron delivery

  2. An integrated coherent anti-Stokes Raman scattering and multiphoton imaging technique for liver disease diagnosis

    NASA Astrophysics Data System (ADS)

    Lin, Jian; Lu, Fake; Zheng, Wei; Yu, Hanry; Sheppard, Colin; Huang, Zhiwei

    2012-03-01

    Liver steatosis and fibrosis are two prevalence liver diseases and may eventually develop into hepatocellular carcinoma (HCC) Due to their prevalence and severity, much work has been done to develop efficient diagnostic methods and therapies. Nonlinear optical microscopy has high sensitivity and chemical specificity for major biochemical compounds, making it a powerful tool for tissue imaging without staining. In this study, three nonlinear microscopy imaging modalities are applied to the study of liver diseases in a bile duct ligation rat modal. CARS shows the distributions of fats or lipids quantitatively across the tissue; SHG visualizes the collagens; and TPEF reveals the morphology of hepatic cells. The results clearly show the development of liver steatosis and fibrosis with time, and the hepatic fat and collagen fibrils are quantified. This study demonstrates the ability of multimodal nonlinear optical microscopy for liver disease diagnosis, and may provide new insights into the understanding of the mechanisms of steatosis/fibrosis transformations at the cellular and molecular levels.

  3. Scaling Analysis Techniques to Establish Experimental Infrastructure for Component, Subsystem, and Integrated System Testing

    SciTech Connect

    Sabharwall, Piyush; O'Brien, James E.; McKellar, Michael G.; Housley, Gregory K.; Bragg-Sitton, Shannon M.

    2015-03-01

    Hybrid energy system research has the potential to expand the application for nuclear reactor technology beyond electricity. The purpose of this research is to reduce both technical and economic risks associated with energy systems of the future. Nuclear hybrid energy systems (NHES) mitigate the variability of renewable energy sources, provide opportunities to produce revenue from different product streams, and avoid capital inefficiencies by matching electrical output to demand by using excess generation capacity for other purposes when it is available. An essential step in the commercialization and deployment of this advanced technology is scaled testing to demonstrate integrated dynamic performance of advanced systems and components when risks cannot be mitigated adequately by analysis or simulation. Further testing in a prototypical environment is needed for validation and higher confidence. This research supports the development of advanced nuclear reactor technology and NHES, and their adaptation to commercial industrial applications that will potentially advance U.S. energy security, economy, and reliability and further reduce carbon emissions. Experimental infrastructure development for testing and feasibility studies of coupled systems can similarly support other projects having similar developmental needs and can generate data required for validation of models in thermal energy storage and transport, energy, and conversion process development. Experiments performed in the Systems Integration Laboratory will acquire performance data, identify scalability issues, and quantify technology gaps and needs for various hybrid or other energy systems. This report discusses detailed scaling (component and integrated system) and heat transfer figures of merit that will establish the experimental infrastructure for component, subsystem, and integrated system testing to advance the technology readiness of components and systems to the level required for commercial

  4. Process Product Integrity Audits: A Hardware Auditing Technique for the '90s'

    NASA Technical Reports Server (NTRS)

    Taylor, Mike

    1994-01-01

    The Space Shuttle program has experienced hardware problems that have delayed several shuttle launches. A NASA review determined that the problems could have been prevented. NASA further concluded that a new kind of Quality emphasis at all Space Shuttle prime contractors and subcontractors was necessary to ensure mission success. To meet this challenge, NASA initiated an innovative review process called Process/Product Integrity (PPIA).

  5. Personnel techniques necessary to maximize bio-barrier integrity at a Martian receiving laboratory

    NASA Technical Reports Server (NTRS)

    Michaelson, G. S.; Mahoney, T. A.

    1975-01-01

    The planning of biological isolation measures for the Mars Surface Sample Return Mission is discussed in terms of personnel and organizational management. Deficiencies in past operation of the Lunar Receiving Laborator are analyzed. It was found that the failure to clearly define relationship among the government agencies involved and to effectively integrate their objectives and responsibilities was a major cause of Laboratory deficiencies. Possible solutions to these problems are presented for application to future missions.

  6. Radar and satellite area-time-integral techniques for estimating convective precipitation

    NASA Technical Reports Server (NTRS)

    Smith, Paul L.; Johnson, L. Ronald; Vonder Haar, Thomas H.; Reinke, Don

    1990-01-01

    The application of the area-time-integral (ATI) method (Doneaud et al, 1984) to radar and satellite measurements is reviewed. Results are presented from the calculation of ATI values from radar observations based on low-elevation-angle and low-altitude CAPPI data. Also, results from a satellite ATI calculation using IR images from a GEO platform are given. The results suggest that the radar and satellite applications produce good consistency.

  7. Importance of integrated results of different non-destructive techniques in order to evaluate defects in panel paintings: the contribution of infrared, optical and ultrasonic techniques

    NASA Astrophysics Data System (ADS)

    Sfarra, S.; Theodorakeas, P.; Ibarra-Castanedo, C.; Avdelidis, N. P.; Paoletti, A.; Paoletti, D.; Hrissagis, K.; Bendada, A.; Koui, M.; Maldague, X.

    2011-06-01

    The increasing deterioration of panel paintings can be due to physical processes that take place during exhibition or transit, or as a result of temperature and humidity fluctuations within a building, church or museum. In response to environmental alterations, a panel painting can expand or contract and a new equilibrium state is eventually reached. These adjustments though, are usually accompanied by a change in shape in order to accommodate to the new conditions. In this work, a holographic method for detecting detached regions and micro-cracks is described. Some of these defects are confirmed by Thermographic Signal Reconstruction (TSR) technique. In addition, Pulsed Phase Thermography (PPT) and Principal Component Thermography (PCT) allow to identify with greater contrast two artificial defects in Mylar which are crucial to understand the topic of interest: the discrimination between defect materials. Finally, traditional contact ultrasounds applications, are widely applied for the evaluation of the wood quality in several characterization procedures. Inspecting the specimen from the front side, the natural and artificial defects of the specimen are confirmed. Experimental results derived by the application of the integrated methods on an Italian panel painting reproduction, called The Angel specimen, are presented. The main advantages that these techniques can offer to the conservation and restoration of artworks are emphasized.

  8. Correcting for underlying absorption interferences in Fourier transform infrared trans analysis of edible oils using two-dimensional correlation techniques.

    PubMed

    van de Voort, F R; Sedman, J; Sherazi, S T H

    2008-03-12

    Substantive improvement in the sensitivity of the AOAC/AOCS spectral ratioing method for the determination of isolated trans isomers in edible oils was recently achieved by the application of a new spectral reconstitution (SR) technique that facilitates the FTIR analysis of edible oils in the transmission mode. However, the general applicability of the spectral ratioing method is still severely limited by the requirement to know the provenance of the oil to be analyzed and have on hand its trans-free counterpart so that the underlying triacylglycerol absorptions in the trans measurement region (990-945 cm(-1)), henceforth referred to as UAt , may be ratioed out. To eliminate the need for a trans-free reference oil, we have employed two-dimensional (2D) correlation spectroscopy to search for other spectral features that might correlate with and serve to estimate the UAt . The three-dimensional contour maps obtained by 2D correlation analysis of the spectra of 10 trans-free oils of different oil types, recorded using the SR procedure, revealed such correlations in two spectral regions, 1700-1600 and 4500-4300 cm(-1), exhibiting one maximum and two maxima, respectively, with wavenumber coordinates of (968, 4407), (968, 4299), and (968, 1650). The latter two correlations, when optimized, produced excellent linear regression relationships (r>0.95) with the UAt . The spectra of five sets of trielaidin-spiked oils were corrected for the UA t using these relationships, and their trans contents were predicted from the calibration equation generated for the spectral ratioing procedure. Linear regression of predicted versus added trans over the range of 0-1.6% trans, which is below the limit of quantitation of the AOAC/AOCS spectral ratioing method, yielded r=0.88-0.90 with an SD of approximately 0.2% trans. These results indicate that the combination of the SR technique with the UA t correction approach may provide a simple and accurate FTIR method for the analysis of the

  9. Discrete Fourier Transform as applicable technique in electrochemical detection of hydrazine using multi-walled carbon nanotube/polyacrylonitrile ceramic fiber as working electrode.

    PubMed

    Doroodmand, Mohammad Mahdi

    2013-05-01

    Effect of "Discrete Fourier Transform" (DFT) is studied for electrochemical detection of some electroactive species using multi-walled carbon nanotube/polyacrylonitrile ceramic fiber as ultra micro electrode. Based on DFT theory, two independent phases i.e. the imaginary and real phases are evaluated during the oxidation/reduction of the quasi-reversible or irreversible electroactive species, revealing the independent components of imaginary (IImaginary) and real (IReal) currents. The results show that, in different electrochemical modes such as cyclic voltammetry (CV), the contribution of DFT to the electrochemical signals significantly improves the detection limit of the electrochemical technique. More sensitive signals are obtained at high scan rates according to the combination of electrochemical techniques with the DFT theory. The reliability of DFT algorithm was evaluated for rapid determination of trace amount of hydrazine (N2H4) at a scan rate up to 800 V s(-1). In this study, the amounts of phase and amplitude were estimated to 1.69 and 31.57, respectively. The detection limit of hydrazine was 4.13×10(-9) M. The application of this technique was also evaluated for determination of hydrazine in different industrial wastewater samples. PMID:23498220

  10. Rainbow Fourier Transform

    NASA Technical Reports Server (NTRS)

    Alexandrov, Mikhail D.; Cairns, Brian; Mishchenko, Michael I.

    2012-01-01

    We present a novel technique for remote sensing of cloud droplet size distributions. Polarized reflectances in the scattering angle range between 135deg and 165deg exhibit a sharply defined rainbow structure, the shape of which is determined mostly by single scattering properties of cloud particles, and therefore, can be modeled using the Mie theory. Fitting the observed rainbow with such a model (computed for a parameterized family of particle size distributions) has been used for cloud droplet size retrievals. We discovered that the relationship between the rainbow structures and the corresponding particle size distributions is deeper than it had been commonly understood. In fact, the Mie theory-derived polarized reflectance as a function of reduced scattering angle (in the rainbow angular range) and the (monodisperse) particle radius appears to be a proxy to a kernel of an integral transform (similar to the sine Fourier transform on the positive semi-axis). This approach, called the rainbow Fourier transform (RFT), allows us to accurately retrieve the shape of the droplet size distribution by the application of the corresponding inverse transform to the observed polarized rainbow. While the basis functions of the proxy-transform are not exactly orthogonal in the finite angular range, this procedure needs to be complemented by a simple regression technique, which removes the retrieval artifacts. This non-parametric approach does not require any a priori knowledge of the droplet size distribution functional shape and is computationally fast (no look-up tables, no fitting, computations are the same as for the forward modeling).

  11. The quest for tolerant varieties: the importance of integrating "omics" techniques to phenotyping.

    PubMed

    Zivy, Michel; Wienkoop, Stefanie; Renaut, Jenny; Pinheiro, Carla; Goulas, Estelle; Carpentier, Sebastien

    2015-01-01

    The primary objective of crop breeding is to improve yield and/or harvest quality while minimizing inputs. Global climate change and the increase in world population are significant challenges for agriculture and call for further improvements to crops and the development of new tools for research. Significant progress has been made in the molecular and genetic analysis of model plants. However, is science generating false expectations? Are 'omic techniques generating valuable information that can be translated into the field? The exploration of crop biodiversity and the correlation of cellular responses to stress tolerance at the plant level is currently a challenge. This viewpoint reviews concisely the problems one encounters when working on a crop and provides an outline of possible workflows when initiating cellular phenotyping via "-omic" techniques (transcriptomics, proteomics, metabolomics). PMID:26217344

  12. The quest for tolerant varieties: the importance of integrating “omics” techniques to phenotyping

    PubMed Central

    Zivy, Michel; Wienkoop, Stefanie; Renaut, Jenny; Pinheiro, Carla; Goulas, Estelle; Carpentier, Sebastien

    2015-01-01

    The primary objective of crop breeding is to improve yield and/or harvest quality while minimizing inputs. Global climate change and the increase in world population are significant challenges for agriculture and call for further improvements to crops and the development of new tools for research. Significant progress has been made in the molecular and genetic analysis of model plants. However, is science generating false expectations? Are ‘omic techniques generating valuable information that can be translated into the field? The exploration of crop biodiversity and the correlation of cellular responses to stress tolerance at the plant level is currently a challenge. This viewpoint reviews concisely the problems one encounters when working on a crop and provides an outline of possible workflows when initiating cellular phenotyping via “-omic” techniques (transcriptomics, proteomics, metabolomics). PMID:26217344

  13. Comparing and visualizing titanium implant integration in rat bone using 2D and 3D techniques.

    PubMed

    Arvidsson, Anna; Sarve, Hamid; Johansson, Carina B

    2015-01-01

    The aim was to compare the osseointegration of grit-blasted implants with and without a hydrogen fluoride treatment in rat tibia and femur, and to visualize bone formation using state-of-the-art 3D visualization techniques. Grit-blasted implants were inserted in femur and tibia of 10 Sprague-Dawley rats (4 implants/rat). Four weeks after insertion, bone implant samples were retrieved. Selected samples were imaged in 3D using Synchrotron Radiation-based μCT (SRμCT). The 3D data was quantified and visualized using two novel visualization techniques, thread fly-through and 2D unfolding. All samples were processed to cut and ground sections and 2D histomorphometrical comparisons of bone implant contact (BIC), bone area (BA), and mirror image area (MI) were performed. BA values were statistically significantly higher for test implants than controls (p < 0.05), but BIC and MI data did not differ significantly. Thus, the results partly indicate improved bone formation at blasted and hydrogen fluoride treated implants, compared to blasted implants. The 3D analysis was a valuable complement to 2D analysis, facilitating improved visualization. However, further studies are required to evaluate aspects of 3D quantitative techniques, with relation to light microscopy that traditionally is used for osseointegration studies.

  14. Comparing and visualizing titanium implant integration in rat bone using 2D and 3D techniques.

    PubMed

    Arvidsson, Anna; Sarve, Hamid; Johansson, Carina B

    2015-01-01

    The aim was to compare the osseointegration of grit-blasted implants with and without a hydrogen fluoride treatment in rat tibia and femur, and to visualize bone formation using state-of-the-art 3D visualization techniques. Grit-blasted implants were inserted in femur and tibia of 10 Sprague-Dawley rats (4 implants/rat). Four weeks after insertion, bone implant samples were retrieved. Selected samples were imaged in 3D using Synchrotron Radiation-based μCT (SRμCT). The 3D data was quantified and visualized using two novel visualization techniques, thread fly-through and 2D unfolding. All samples were processed to cut and ground sections and 2D histomorphometrical comparisons of bone implant contact (BIC), bone area (BA), and mirror image area (MI) were performed. BA values were statistically significantly higher for test implants than controls (p < 0.05), but BIC and MI data did not differ significantly. Thus, the results partly indicate improved bone formation at blasted and hydrogen fluoride treated implants, compared to blasted implants. The 3D analysis was a valuable complement to 2D analysis, facilitating improved visualization. However, further studies are required to evaluate aspects of 3D quantitative techniques, with relation to light microscopy that traditionally is used for osseointegration studies. PMID:24711247

  15. Combination of different microscopy techniques for the integrated study of extremophile endolithic microorganisms and their habitats

    NASA Astrophysics Data System (ADS)

    de Los Ríos, Asunción; Wierzchos, Jacek; Sancho, Leopoldo G.; Ascaso, Carmen

    2001-08-01

    Some micro-organisms are able to withstand extreme environments and form communities within rocks. To characterise these endolithic micro-ecosystems, several microscopy and microanalytical approaches need to be combined, including scanning electron microscopy with back scattered electron imaging (SEM-BSE), low temperature scanning electron microscopy (LTSEM), confocal scanning laser microscopy (CSLM), and the X-ray energy dispersive spectroscopy (EDS) microanalytical system. These techniques have allowed the simultaneous observation of these micro-organisms and their habitats. SEM-BSE and LTSEM serve to evaluate the biodiversity of the rock from a morphological and ultrastructural perspective. LTSEM also permits water localisation in the cells and their microhabitats. Information on the spatial distribution of the micro-organisms inside the rock is provided by CSLM. Lithobiontic communities have been shown to interact with their substrate. The EDS technique coupled to SEM-BSE permits the chemical characterisation of mineral features, the detection of biomobilisation and biomineralisation processes, and yields information on the chemical environment. These techniques are also applicable in the search for fossilised micro-organisms.

  16. Electrokinetic remediation of organochlorines in soil: enhancement techniques and integration with other remediation technologies.

    PubMed

    Gomes, Helena I; Dias-Ferreira, Celia; Ribeiro, Alexandra B

    2012-06-01

    Electrokinetic remediation has been increasingly used in soils and other matrices for numerous contaminants such as inorganic, organic, radionuclides, explosives and their mixtures. Several strategies were tested to improve this technology effectiveness, namely techniques to solubilize contaminants, control soil pH and also couple electrokinetics with other remediation technologies. This review focus in the experimental work carried out in organochlorines soil electroremediation, aiming to systemize useful information to researchers in this field. It is not possible to clearly state what technique is the best, since experimental approaches and targeted contaminants are different. Further research is needed in the application of some of the reviewed techniques. Also a number of technical and environmental issues will require evaluation for full-scale application. Removal efficiencies reported in real contaminated soils are much lower than the ones obtained with spiked kaolinite, showing the influence of other factors like aging of the contamination and adsorption to soil particles, resulting in important challenges when transferring technologies into the field. PMID:22386462

  17. Virtual Manufacturing Techniques Designed and Applied to Manufacturing Activities in the Manufacturing Integration and Technology Branch

    NASA Technical Reports Server (NTRS)

    Shearrow, Charles A.

    1999-01-01

    One of the identified goals of EM3 is to implement virtual manufacturing by the time the year 2000 has ended. To realize this goal of a true virtual manufacturing enterprise the initial development of a machinability database and the infrastructure must be completed. This will consist of the containment of the existing EM-NET problems and developing machine, tooling, and common materials databases. To integrate the virtual manufacturing enterprise with normal day to day operations the development of a parallel virtual manufacturing machinability database, virtual manufacturing database, virtual manufacturing paradigm, implementation/integration procedure, and testable verification models must be constructed. Common and virtual machinability databases will include the four distinct areas of machine tools, available tooling, common machine tool loads, and a materials database. The machine tools database will include the machine envelope, special machine attachments, tooling capacity, location within NASA-JSC or with a contractor, and availability/scheduling. The tooling database will include available standard tooling, custom in-house tooling, tool properties, and availability. The common materials database will include materials thickness ranges, strengths, types, and their availability. The virtual manufacturing databases will consist of virtual machines and virtual tooling directly related to the common and machinability databases. The items to be completed are the design and construction of the machinability databases, virtual manufacturing paradigm for NASA-JSC, implementation timeline, VNC model of one bridge mill and troubleshoot existing software and hardware problems with EN4NET. The final step of this virtual manufacturing project will be to integrate other production sites into the databases bringing JSC's EM3 into a position of becoming a clearing house for NASA's digital manufacturing needs creating a true virtual manufacturing enterprise.

  18. Integrating complementary medicine literacy education into Australian medical curricula: Student-identified techniques and strategies for implementation.

    PubMed

    Templeman, Kate; Robinson, Anske; McKenna, Lisa

    2015-11-01

    Formal medical education about complementary medicine (CM) that comprises medicinal products/treatments is required due to possible CM interactions with conventional medicines; however, few guidelines exist on design and implementation of such education. This paper reports findings of a constructivist grounded theory method study that identified key strategies for integrating CM literacy education into medical curricula. Analysis of data from interviews with 30 medical students showed that students supported a longitudinal integrative and pluralistic approach to medicine. Awareness of common patient use, evidence, and information relevant to future clinical practice were identified as focus points needed for CM literacy education. Students advocated for interactive case-based, experiential and dialogical didactic techniques that are multiprofessional and student-centred. Suggested strategies provide key elements of CM literacy within research, field-based practice, and didactic teaching over the entirety of the curriculum. CM educational strategies should address CM knowledge deficits and ultimately respond to patients' needs.

  19. Integrating complementary medicine literacy education into Australian medical curricula: Student-identified techniques and strategies for implementation.

    PubMed

    Templeman, Kate; Robinson, Anske; McKenna, Lisa

    2015-11-01

    Formal medical education about complementary medicine (CM) that comprises medicinal products/treatments is required due to possible CM interactions with conventional medicines; however, few guidelines exist on design and implementation of such education. This paper reports findings of a constructivist grounded theory method study that identified key strategies for integrating CM literacy education into medical curricula. Analysis of data from interviews with 30 medical students showed that students supported a longitudinal integrative and pluralistic approach to medicine. Awareness of common patient use, evidence, and information relevant to future clinical practice were identified as focus points needed for CM literacy education. Students advocated for interactive case-based, experiential and dialogical didactic techniques that are multiprofessional and student-centred. Suggested strategies provide key elements of CM literacy within research, field-based practice, and didactic teaching over the entirety of the curriculum. CM educational strategies should address CM knowledge deficits and ultimately respond to patients' needs. PMID:26573450

  20. Technique for integrative energy planning in developing nations with illustrative application to Pakistan. (Volumes I and II)

    SciTech Connect

    Ciliano, R.E.

    1985-01-01

    This dissertation focuses on the conceptual definition, development and illustrative application of a new methodology for integrative energy planning in less developed countries (LDCs). The author terms his approach the Integrative Planning Technique (IPT). The IPT provides a direct linkage between sectoral activity levels and targets specified in the overall economic development plan and the energy system physical infrastructure and resource flows upon which they depend. Central concepts within the IPT include (a) the Energy Resource Delivery Network (ERDN), a network representation of the overall energy system from resource extraction through ultimate end-use; and (b) the Resource Coefficient Table (RCT), a computational matrix method which prepares inputs to the ERDN and provides the building block basis for translating policy initiatives relating to new technology penetration, interfuel substitution, and re-directed development targets into corresponding energy requirements associated with policy implementation.

  1. LC-MS screening techniques for wastewater analysis and analytical data handling strategies: Sartans and their transformation products as an example.

    PubMed

    Letzel, Thomas; Bayer, Anne; Schulz, Wolfgang; Heermann, Alexandra; Lucke, Thomas; Greco, Giorgia; Grosse, Sylvia; Schüssler, Walter; Sengl, Manfred; Letzel, Marion

    2015-10-01

    A large number of anthropogenic trace contaminants such as pharmaceuticals, their human metabolites and further transformation products (TPs) enter wastewater treatment plants on a daily basis. A mixture of known, expected, and unknown molecules are discharged into the receiving aquatic environment because only partial elimination occurs for many of these chemicals during physical, biological and chemical treatment processes. In this study, an array of LC-MS methods from three collaborating laboratories was applied to detect and identify anthropogenic trace contaminants and their TPs in different waters. Starting with theoretical predictions of TPs, an efficient workflow using the combination of target, suspected-target and non-target strategies for the identification of these TPs in the environment was developed. These techniques and strategies were applied to study anti-hypertensive drugs from the sartan group (i.e., candesartan, eprosartan, irbesartan, olmesartan, and valsartan). Degradation experiments were performed in lab-scale wastewater treatment plants, and a screening workflow including an inter-laboratory approach was used for the identification of transformation products in the effluent samples. Subsequently, newly identified compounds were successfully analyzed in effluents of real wastewater treatment plants and river waters. PMID:26246044

  2. LC-MS screening techniques for wastewater analysis and analytical data handling strategies: Sartans and their transformation products as an example.

    PubMed

    Letzel, Thomas; Bayer, Anne; Schulz, Wolfgang; Heermann, Alexandra; Lucke, Thomas; Greco, Giorgia; Grosse, Sylvia; Schüssler, Walter; Sengl, Manfred; Letzel, Marion

    2015-10-01

    A large number of anthropogenic trace contaminants such as pharmaceuticals, their human metabolites and further transformation products (TPs) enter wastewater treatment plants on a daily basis. A mixture of known, expected, and unknown molecules are discharged into the receiving aquatic environment because only partial elimination occurs for many of these chemicals during physical, biological and chemical treatment processes. In this study, an array of LC-MS methods from three collaborating laboratories was applied to detect and identify anthropogenic trace contaminants and their TPs in different waters. Starting with theoretical predictions of TPs, an efficient workflow using the combination of target, suspected-target and non-target strategies for the identification of these TPs in the environment was developed. These techniques and strategies were applied to study anti-hypertensive drugs from the sartan group (i.e., candesartan, eprosartan, irbesartan, olmesartan, and valsartan). Degradation experiments were performed in lab-scale wastewater treatment plants, and a screening workflow including an inter-laboratory approach was used for the identification of transformation products in the effluent samples. Subsequently, newly identified compounds were successfully analyzed in effluents of real wastewater treatment plants and river waters.

  3. Characterization of ancient glass excavated in Enez (Ancient Ainos) Turkey by combined Instrumental Neutron Activation Analysis and Fourier Transform Infrared spectrometry techniques

    NASA Astrophysics Data System (ADS)

    Akyuz, Sevim; Akyuz, Tanil; Mukhamedshina, Nuranya M.; Mirsagatova, A. Adiba; Basaran, Sait; Cakan, Banu

    2012-05-01

    Ancient glass fragments excavated in the archaeological district Enez (Ancient Ainos)-Turkey were investigated by combined Instrumental Neutron Activation Analysis (INAA) and Fourier Transform Infrared (FTIR) spectrometry techniques. Multi-elemental contents of 15 glass fragments that belong to Hellenistic, Roman, Byzantine, and Ottoman Periods, were determined by INAA. The concentrations of twenty six elements (Na, K, Ca, Sc, Cr, Mn, Fe, Co, Cu, Zn, As, Rb, Sr, Sb, Cs, Ba, Ce, Sm, Eu, Tb, Yb, Lu, Hf, Ta, Au and Th), which might be present in the samples as flux, stabilizers, colorants or opacifiers, and impurities, were examined. Chemometric treatment of the INAA data was performed and principle component analysis revealed presence of 3 distinct groups. The thermal history of the glass samples was determined by FTIR spectrometry.

  4. Advanced Car-Parrinello Techniques: Path Integrals and Nonadiabaticity in Condensed Matter Simulations

    NASA Astrophysics Data System (ADS)

    Marx, D.

    Extensions of Car-Parrinello (CP) ab initio molecular dynamics are presented for efficient treatments of nuclear quantum effects and electronically nonadiabatic processes in the realm of condensed matter simulations. Ab initio path integrals, being a combination of CP propagation of the electrons in conjunction with path integral MD sampling of the nuclei, allow to investigate quantum phenomena, such as the influence of zero-point motion and proton tunneling, in chemically complex systems. Nonadiabatic ab initio simulations rely on the coupling of the Kohn-Sham ground state, S 0, and the first excited electronic state, S 1, obtained within the restricted open-shell Kohn- Sham (ROKS) approach using Tully's surface hopping algorithm. The efficient evaluation of the nonadiabatic couplings together with an "on-the-fly" updating scheme makes possible nonadiabatic ab initio simulations of systems of similar complexity as those typically studied by ground-state CP methods. This method is thus ideally suited to study photoinduced reactions of large molecular systems, particularly in condensed phases.

  5. Analyze and research the integrated navigation technique for GPS and pseudolite

    NASA Astrophysics Data System (ADS)

    Yuan, Gannan; Gan, Xingli; Li, Zhongyu

    2007-11-01

    To heighten the stability and precision of GPS positioning, the integrated navigation system for GPS and pseudolites (GPS/PL) was set up. The nonlinear equation of pseudo-distance measurement was linearized by Taylor series expansion, but it can't find any influencing factors of the truncation error. A new deducing method of the linear equation of pseudo-distance measurement was put forward, and some influencing factors of the truncation error were found and the nonlinear degree was defined. By the comparison of the nonlinear degree for GPS and pseudolites, the truncation error of pseudolite was found much larger than that of GPS navigation during the linearization. In allusion to the stable flight state of aircrafts, the nonlinear system equations of an integrated navigation system for GPS and pseudolites (GPS/PL) were set up, and the unscented Kalman filter (UKF) was used to estimate the navigation parameters to solve the nonlinear problems of PL. The simulation results showed that the maximum positioning error is 14 meters, and the mean value is 7 meters. Thereby, the pseudolites make the enhancement for the positioning precision and system stability of GPS navigation.

  6. Research on regulating technique of material flow for 2-person and 30-day integrated CELSS test

    NASA Astrophysics Data System (ADS)

    Guo, Shuangsheng; Dong, Wenping; Ai, Weidang; Feng, Hongqi; Tang, Yongkang; Huang, Zhide; Shen, Yunze; Ren, Jin; Qin, Lifeng; Zeng, Gu; Zhang, Lihong; Zhu, Jingtao; Fei, Jinxue; Xu, Guoxin

    2014-07-01

    A man-plant integration test was processed using the CELSS integration experiment platform in which 4 kinds of plants were grown (Lactuca sativa L var. Dasusheng, L. sativa L var. Youmaicai, Gynura bicolor and Cichorium endivia L) to exchange material with 2 persons in order to research the dynamic changing laws and balanced regulation of air and water between man and plant in an inclosed system. In the test the material flow was measured so that the dynamically changing laws and balanced regulation of air and water between man and plant in the closed system were mostly mastered. The material closure degree of air, water and food reached 100%, 90% and 13.9% respectively with the whole system closure degree up to 95.1%. Meanwhile, it was proved that a 13.5 m2 planting area could meet the demand of one person for O2 in the system, and the energy efficiency ratio of which reached 59.56 g/(kW m2 day). The material flow dynamic balance-regulating technology was initially mastered between man and plant through the test. The interaction was realized among man, plant and environment in the closed system, which is of great significance to the advancement of long-term manned environment control and life support technology for China.

  7. A prototype of mammography CADx scheme integrated to imaging quality evaluation techniques

    NASA Astrophysics Data System (ADS)

    Schiabel, Homero; Matheus, Bruno R. N.; Angelo, Michele F.; Patrocínio, Ana Claudia; Ventura, Liliane

    2011-03-01

    As all women over the age of 40 are recommended to perform mammographic exams every two years, the demands on radiologists to evaluate mammographic images in short periods of time has increased considerably. As a tool to improve quality and accelerate analysis CADe/Dx (computer-aided detection/diagnosis) schemes have been investigated, but very few complete CADe/Dx schemes have been developed and most are restricted to detection and not diagnosis. The existent ones usually are associated to specific mammographic equipment (usually DR), which makes them very expensive. So this paper describes a prototype of a complete mammography CADx scheme developed by our research group integrated to an imaging quality evaluation process. The basic structure consists of pre-processing modules based on image acquisition and digitization procedures (FFDM, CR or film + scanner), a segmentation tool to detect clustered microcalcifications and suspect masses and a classification scheme, which evaluates as the presence of microcalcifications clusters as well as possible malignant masses based on their contour. The aim is to provide enough information not only on the detected structures but also a pre-report with a BI-RADS classification. At this time the system is still lacking an interface integrating all the modules. Despite this, it is functional as a prototype for clinical practice testing, with results comparable to others reported in literature.

  8. Investigation of Prospective Teachers' Information and Communication Technology Integration Practices in Terms of Transformative Learning Theory

    ERIC Educational Resources Information Center

    Sahin Izmirli, Özden; Kabakçi Yurdakul, Isil

    2014-01-01

    An examination of prospective teachers' information and communication technology (ICT) integration skills development in an undergraduate program indicated that the only course available to practice these skills was the teaching practice course. However, the practice and development of these ICT integration skills in the teaching practice…

  9. "I'll Squeeze It In": Transforming Preservice Classroom Teachers' Perceptions toward Movement Integration in Schools

    ERIC Educational Resources Information Center

    Goh, Tan Leng; Hannon, James C.; Newton, Maria; Webster, Collin; Podlog, Leslie; Pillow, Wanda

    2013-01-01

    A program titled Physical Education Programming Infusion (PEPI) was incorporated into a required science methods course for preservice classroom teachers (PCTs). Using the transformative learning theory and the social ecological model, the authors examined changes in PCTs' personal health behaviors and perceived barriers toward movement…

  10. Case Study for Integration of an Oncology Clinical Site in a Semantic Interoperability Solution based on HL7 v3 and SNOMED-CT: Data Transformation Needs.

    PubMed

    Ibrahim, Ahmed; Bucur, Anca; Perez-Rey, David; Alonso, Enrique; de Hoog, Matthy; Dekker, Andre; Marshall, M Scott

    2015-01-01

    This paper describes the data transformation pipeline defined to support the integration of a new clinical site in a standards-based semantic interoperability environment. The available datasets combined structured and free-text patient data in Dutch, collected in the context of radiation therapy in several cancer types. Our approach aims at both efficiency and data quality. We combine custom-developed scripts, standard tools and manual validation by clinical and knowledge experts. We identified key challenges emerging from the several sources of heterogeneity in our case study (systems, language, data structure, clinical domain) and implemented solutions that we will further generalize for the integration of new sites. We conclude that the required effort for data transformation is manageable which supports the feasibility of our semantic interoperability solution. The achieved semantic interoperability will be leveraged for the deployment and evaluation at the clinical site of applications enabling secondary use of care data for research. This work has been funded by the European Commission through the INTEGRATE (FP7-ICT-2009-6-270253) and EURECA (FP7-ICT-2011-288048) projects.

  11. Are hybrid models integrated with data preprocessing techniques suitable for monthly streamflow forecasting? Some experiment evidences

    NASA Astrophysics Data System (ADS)

    Zhang, Xiaoli; Peng, Yong; Zhang, Chi; Wang, Bende

    2015-11-01

    A number of hydrological studies have proven the superior prediction performance of hybrid models coupled with data preprocessing techniques. However, many studies first decompose the entire data series into components and later divide each component into calibration and validation datasets to establish models, which sends some amount of future information into the decomposition and reconstruction processes. As a consequence, the resulting components used to forecast the value of a particular moment are computed using information from future values, which are not available at that particular moment in a forecasting exercise. Since most papers don't present their model framework in detail, it is difficult to identify whether they are performing a real forecast or not. Even though several other papers have explicitly stated which experiment they are performing, a comparison between results in the hindcast and forecast experiments is still missing. Therefore, it is necessary to investigate and compare the performance of these hybrid models in the two experiments in order to estimate whether they are suitable for real forecasting. With the combination of three preprocessing techniques, such as wavelet analysis (WA), empirical mode decomposition (EMD) and singular spectrum analysis (SSA), and two modeling methods (i.e. ANN model and ARMA model), six hybrid models are developed in this study, including WA-ANN, WA-ARMA, EMD-ANN, EMD-ARMA, SSA-ANN and SSA-ARMA. Preprocessing techniques are used to decompose the data series into sub-series, and then these sub-series are modeled using ANN and ARMA models. These models are examined in hindcasting and forecasting of the monthly streamflow of two sites in the Yangtze River of China. The results of this study indicate that the six hybrid models perform better in the hindcast experiment compared with the original ANN and ARMA models, while the hybrid models in the forecast experiment perform worse than the original models and the

  12. The Integration of Voice and Dance Techniques in Musical Theatre: Anatomical Considerations.

    PubMed

    Morton, Jennie

    2015-06-01

    Musical theatre performers are required to be proficient in the three artistic disciplines of dancing, singing, and acting, although in today's modern productions, there is often a requirement to incorporate other skills such as acrobatics and the playing of an instrument. This article focuses on the issues faced by performers when dancing and voicing simultaneously, as it is between these two disciplines where we see the greatest pedagogical divide in terms of breath management and muscle recruitment patterns. The traditional teaching methods of dance and voice techniques are examined, areas of conflict highlighted, and solutions proposed through an exploration of the relevant anatomy. PMID:26046610

  13. Single mode fiber and twin-core fiber connection technique for in-fiber integrated interferometer

    NASA Astrophysics Data System (ADS)

    Yuan, Tingting; Zhang, Xiaotong; Guan, Chunying; Yang, Xinghua; Yuan, Libo

    2015-09-01

    A novel twin-core fiber connector has been made by two side-polished fibers. By using side polishing technique, we present a connector based on the twin-core fiber (TCF) and two D-shaped single-core fibers. After simple alignment and splicing, all fiber miniaturizing connector can be obtained. Two cores can operate independently and are non-interfering. The coupling loss of this connector is low and the fabrication technologies are mature. The connector device could be used for sensors or particle trapping.

  14. A complex integration technique to remove spurious states associated with spontaneously broken symmetries in RPA calculations

    NASA Astrophysics Data System (ADS)

    Donati, P.; Døssing, T.; Shimizu, Y. R.; Bortignon, P. F.; Broglia, R. A.

    1999-06-01

    The removal of the spurious states associated with the violation of rotational and gauge invariance by mean field approximation from the RPA solutions describing the low-energy spectrum of nuclei is a notoriously difficult task, in particular in a rotating frame. A novel, numerically accurate yet technically simple method to accomplish this aim has been developed based on linear response theory. The results of calculations carried out for the deformed, superfluid, rotating nucleus 168Yb testify to the power of the technique, the associated solutions respecting the variety of sum rules required to be fulfilled by the RPA solutions because of conservation laws.

  15. Sublacustrine groundwater discharge in esker aquifers; fully integrated groundwater flow modeling compared with novel field techniques

    NASA Astrophysics Data System (ADS)

    Ala-aho, Pertti; Rossi, Pekka M.; Isokangas, Elina; Kløve, Bjørn

    2015-04-01

    Groundwater (GW) discharge to surface water bodies such as streams, lakes and wetlands can greatly affect their water quantity, quality and related aquatic ecology. Therefore better understanding of GW - surface water interaction is needed in integrated management of water resources. Sublacustrine groundwater discharge (SGD) to lakes was studied in a complex unconfined Rokua esker aquifer system. SGD was studied for 12 lakes in the area to better understand water and solute inputs through lake beds and thereby the role of GW on lake water budget and solute concentrations. The locations and fluxes of SGD were simulated using a fully integrated groundwater flow model HydroGeoSphere. The used hydrological simulator allows water to flow and partition into overland and stream flow, evaporation, infiltration, and subsurface discharge into surface water features in a physically-based way, which was needed in simulating SGD of the complex aquifer system. The model was first calibrated for subsurface hydraulic conductivity in steady state using data of measured long-term average groundwater and lake levels and stream baseflow. The model performance in transient simulations was then examined against recorded hydrographs for lake and groundwater levels and stream flow. After model performance was verified, the simulated locations and fluxes of SGD were extracted from the model and compared with results from three independent field methods: airborne thermal imaging, stable isotope water balance and seepage meter measurements. Airborne thermal imaging was used to infer locations of SGD into lakes based on temperature anomalies at lakes shorelines due to discharging cold groundwater. Isotopic composition (H2 and O18) was analysed for lake water, groundwater and the data was used to estimate SGD flux into lakes. Finally, seepage meter measurements were conducted for one of the lakes to establish both locations and fluxes of SGD in detail. The simulated and field-based estimated

  16. Using the Rasch model as an objective and probabilistic technique to integrate different soil properties

    NASA Astrophysics Data System (ADS)

    Rebollo, Francisco J.; Jesús Moral García, Francisco

    2016-04-01

    Soil apparent electrical conductivity (ECa) is one of the simplest, least expensive soil measurements that integrates many soil properties affecting crop productivity, including, for instance, soil texture, water content, and cation exchange capacity. The ECa measurements obtained with a 3100 Veris sensor, operating in both shallow (0-30 cm), ECs, and deep (0-90 cm), ECd, mode, can be used as an additional and essential information to be included in a probabilistic model, the Rasch model, with the aim of quantifying the overall soil fertililty potential in an agricultural field. This quantification should integrate the main soil physical and chemical properties, with different units. In this work, the formulation of the Rasch model integrates 11 soil properties (clay, silt and sand content, organic matter -OM-, pH, total nitrogen -TN-, available phosphorus -AP- and potassium -AK-, cation exchange capacity -CEC-, ECd, and ECs) measured at 70 locations in a field. The main outputs of the model include a ranking of all soil samples according to their relative fertility potential and the unexpected behaviours of some soil samples and properties. In the case study, the considered soil variables fit the model reasonably, having an important influence on soil fertility, except pH, probably due to its homogeneity in the field. Moreover, ECd, ECs are the most influential properties on soil fertility and, on the other hand, AP and AK the less influential properties. The use of the Rasch model to estimate soil fertility potential (always in a relative way, taking into account the characteristics of the studied soil) constitutes a new application of great practical importance, enabling to rationally determine locations in a field where high soil fertility potential exists and establishing those soil samples or properties which have any anomaly; this information can be necessary to conduct site-specific treatments, leading to a more cost-effective and sustainable field

  17. Coastal typology: An integrative "neutral" technique for coastal zone characterization and analysis

    USGS Publications Warehouse

    Buddemeier, R.W.; Smith, S.V.; Swaney, D.P.; Crossland, C.J.; Maxwell, B.A.

    2008-01-01

    Typology, the 'study or systematic classification of types that have characteristics or traits in common', has become a commonly used term and technique in coastal zone studies over the past two decades. At least part of this is due to adoption by the first Land-Ocean Interactions in the Coastal Zone (LOICZ) project of a typological approach as a way to understand and organize the daunting diversity of natural and human systems comprising the world coastal zone, and to the concurrent development of tools and databases to support systematic applications. This paper reviews some of the history of the term 'typology' and the concepts and techniques that it subsumes, and discusses its adoption and adaptation in coastal studies. It also addresses the continued and increasing relevance of typology to the continuation of the LOICZ project and its objectives, and outlines the opportunities and challenges involved in realizing the potentials of the approach - both within LOICZ and for the scientific and coastal zone communities in general. ?? 2007 Elsevier Ltd. All rights reserved.

  18. A prediction technique for single-event effects on complex integrated circuits

    NASA Astrophysics Data System (ADS)

    Yuanfu, Zhao; Chunqing, Yu; Long, Fan; Suge, Yue; Maoxin, Chen; Shougang, Du; Hongchao, Zheng

    2015-11-01

    The sensitivity of complex integrated circuits to single-event effects is investigated. Sensitivity depends not only on the cross section of physical modules but also on the behavior of data patterns running on the system. A method dividing the main functional modules is proposed. The intrinsic cross section and the duty cycles of different sensitive modules are obtained during the execution of data patterns. A method for extracting the duty cycle is presented and a set of test patterns with different duty cycles are implemented experimentally. By combining the intrinsic cross section and the duty cycle of different sensitive modules, a universal method to predict SEE sensitivities of different test patterns is proposed, which is verified by experiments based on the target circuit of a microprocessor. Experimental results show that the deviation between prediction and experiment is less than 20%.

  19. Visualization of Telomere Integrity and Function In Vitro and In Vivo Using Immunofluorescence Techniques

    PubMed Central

    Cesare, Anthony J.; Heaphy, Christopher M.; O’Sullivan, Roderick J.

    2016-01-01

    In cancer cells, telomere length maintenance occurs largely via the direct synthesis of TTAGGG repeats at chromosome ends by telomerase, or less frequently by the recombination-dependent alternative lengthening of telomeres (ALT) pathway. The latter is characterized by the atypical clustering of telomeres within promyelocytic leukemia (PML) nuclear bodies, which harbor proteins that are linked with DNA repair and recombination activity. For this reason, it is speculated that these associated PML bodies represent the sites of the recombination that maintains telomere length. The protocols described here can be employed for the routine investigation of the structural integrity of telomeres and the association of proteins at telomeres in normal cells, challenged cells, and archived formalin-fixed paraffin-embedded clinical tissue specimens that may have activated the ALT pathway. PMID:26132175

  20. Organic nanofibers integrated by transfer technique in field-effect transistor devices

    PubMed Central

    2011-01-01

    The electrical properties of self-assembled organic crystalline nanofibers are studied by integrating these on field-effect transistor platforms using both top and bottom contact configurations. In the staggered geometries, where the nanofibers are sandwiched between the gate and the source-drain electrodes, a better electrical conduction is observed when compared to the coplanar geometry where the nanofibers are placed over the gate and the source-drain electrodes. Qualitatively different output characteristics were observed for top and bottom contact devices reflecting the significantly different contact resistances. Bottom contact devices are dominated by contact effects, while the top contact device characteristics are determined by the nanofiber bulk properties. It is found that the contact resistance is lower for crystalline nanofibers when compared to amorphous thin films. These results shed light on the charge injection and transport properties for such organic nanostructures and thus constitute a significant step forward toward a nanofiber-based light-emitting device. PMID:21711821

  1. Flash Lamp Integrating Sphere Technique for Measuring the Dynamic Reflectance of Shocked Materials

    SciTech Connect

    Stevens, Gerald; La Lone, Brandon; Veeser, Lynn; Hixson, Rob; Holtkamp, David

    2013-07-08

    Accurate reflectance (R) measurements of metals undergoing shock wave compression can benefit high pressure research in several ways. For example, pressure dependent reflectance measurements can be used to deduce electronic band structure, and discrete changes with pressure or temperature may indicate the occurrence of a phase boundary. Additionally, knowledge of the wavelength dependent emissivity (1 -R, for opaque samples) of the metal surface is essential for accurate pyrometric temperature measurement because the radiance is a function of both the temperature and emissivity. We have developed a method for measuring dynamic reflectance in the visible and near IR spectral regions with nanosecond response time and less than 1.5% uncertainty. The method utilizes an integrating sphere fitted with a xenon flash-lamp illumination source. Because of the integrating sphere, the measurements are insensitive to changes in surface curvature or tilt. The in-situ high brightness of the flash-lamp exceeds the sample’s thermal radiance and also enables the use of solid state detectors for recording the reflectance signals with minimal noise. Using the method, we have examined the dynamic reflectance of gallium and tin subjected to shock compression from high explosives. The results suggest significant reflectance changes across phase boundaries for both metals. We have also used the method to determine the spectral emissivity of shock compressed tin at the interface between tin and a LiF window. The results were used to perform emissivity corrections to previous pyrometry data and obtain shock temperatures of the tin/LiF interface with uncertainties of less than 2%.

  2. Integrated Stamping Simulation Using State Of The Art Techniques To Fulfill Quality Assessment Requirements

    NASA Astrophysics Data System (ADS)

    Ling, David; Lambriks, Marc; El Khaldi, Fouad

    2005-08-01

    The last few years have seen the use of stamping simulation evolve to the extent that it is now a mainstream activity; a core part of the press tool engineering process. Now, new requirements for the use of challenging materials like Dual phase / Complex phase steel, VHSS, and aluminum, together with more stringent quality expectations, and shorter development cycles, there is a need to assess the panel quality in a wider context, before committing to tool manufacture. The integrated approach from ESI Group allows early up-front feasibility assessment, geometry and process optimization, and detailed process validation all within one system. Rapid die design and quick forming simulation modules play an essential role in the early stages of the process. A seamless connection between simulation and geometry is a vital characteristic, with the accurate simulation being used to validate and fine tune the process in order to assess final component quality in unprecedented detail, utilizing some of the most accurate material models available today. The combination of the distributed memory processing (DMP) solver together with new cost effective cluster based compute servers provide a practical solution to the problems of `one million element' model sizes, and more sophisticated modeling methodologies become realistic for the first time. It is no longer sufficient to merely focus on the draw die, forming simulation must now consider the entire die line up. Typically, around half of forming issues arise from the draw die, so the time has now come to address the other half as well! This paper will discuss how the PAM-STAMP 2G™ integrated solution is successfully used to deliver a positive business impact, by providing virtual panel quality assessment, tolerance control, and springback compensation. The paper will also discuss how other forming processes can be accurately modeled using the new modules.

  3. Integration of Advanced Probabilistic Analysis Techniques with Multi-Physics Models

    SciTech Connect

    Cetiner, Mustafa Sacit; none,; Flanagan, George F.; Poore III, Willis P.; Muhlheim, Michael David

    2014-07-30

    An integrated simulation platform that couples probabilistic analysis-based tools with model-based simulation tools can provide valuable insights for reactive and proactive responses to plant operating conditions. The objective of this work is to demonstrate the benefits of a partial implementation of the Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Detailed Framework Specification through the coupling of advanced PRA capabilities and accurate multi-physics plant models. Coupling a probabilistic model with a multi-physics model will aid in design, operations, and safety by providing a more accurate understanding of plant behavior. This represents the first attempt at actually integrating these two types of analyses for a control system used for operations, on a faster than real-time basis. This report documents the development of the basic communication capability to exchange data with the probabilistic model using Reliability Workbench (RWB) and the multi-physics model using Dymola. The communication pathways from injecting a fault (i.e., failing a component) to the probabilistic and multi-physics models were successfully completed. This first version was tested with prototypic models represented in both RWB and Modelica. First, a simple event tree/fault tree (ET/FT) model was created to develop the software code to implement the communication capabilities between the dynamic-link library (dll) and RWB. A program, written in C#, successfully communicates faults to the probabilistic model through the dll. A systems model of the Advanced Liquid-Metal Reactor–Power Reactor Inherently Safe Module (ALMR-PRISM) design developed under another DOE project was upgraded using Dymola to include proper interfaces to allow data exchange with the control application (ConApp). A program, written in C+, successfully communicates faults to the multi-physics model. The results of the example simulation were successfully plotted.

  4. Optical source transformations.

    PubMed

    Kundtz, N; Roberts, D A; Allen, J; Cummer, S; Smith, D R

    2008-12-22

    Transformation optics is a recently appreciated methodology for the design of complex media that control the propagation of electromagnetic and other types of waves. The transformation optical technique involves the use of coordinate transformations applied to some region of space, providing a conceptual means to redirect the flow of waves. Successfully designed devices to date have made use of transformations acting on passive space only; however, the technique can also be applied when source distributions (e.g., current and charge) are included within the space being transformed. In this paper we present examples of source transformations that illustrate the potential of these expanded transformation optical methods. In particular, using finite-element full-wave simulations, we confirm the restoration of dipole radiation patterns from both a distorted 'pin-wheel' antenna and a bent dipole partially occluded by a cylindrical scatterer. We propose the technique of source transformations as a powerful approach for antenna design, especially in relation to conformal antennas.

  5. How to (path-) integrate by differentiating

    NASA Astrophysics Data System (ADS)

    Kempf, Achim; Jackson, David M.; Morales, Alejandro H.

    2015-07-01

    Path integrals are at the heart of quantum field theory. In spite of their covariance and seeming simplicity, they are hard to define and evaluate. In contrast, functional differentiation, as it is used, for example, in variational problems, is relatively straightforward. This has motivated the development of new techniques that allow one to express functional integration in terms of functional differentiation. In fact, the new techniques allow one to express integrals in general through differentiation. These techniques therefore add to the general toolbox for integration and for integral transforms such as the Fourier and Laplace transforms. Here, we review some of these results, we give simpler proofs and we add new results, for example, on expressing the Laplace transform and its inverse in terms of derivatives, results that may be of use in quantum field theory, e.g., in the context of heat traces.

  6. An integrated study of earth resources in the state of California using remote sensing techniques

    NASA Technical Reports Server (NTRS)

    Colwell, R. N. (Principal Investigator)

    1975-01-01

    The author has identified the following significant results. A weighted stratified double sample design using hardcopy LANDSAT-1 and ground data was utilized in developmental studies for snow water content estimation. Study results gave a correlation coefficient of 0.80 between LANDSAT sample units estimates of snow water content and ground subsamples. A basin snow water content estimate allowable error was given as 1.00 percent at the 99 percent confidence level with the same budget level utilized in conventional snow surveys. Several evapotranspiration estimation models were selected for efficient application at each level of data to be sampled. An area estimation procedure for impervious surface types of differing impermeability adjacent to stream channels was developed. This technique employs a double sample of 1:125,000 color infrared hightflight transparency data with ground or large scale photography.

  7. Integration of artificial intelligence and numerical optimization techniques for the design of complex aerospace systems

    SciTech Connect

    Tong, S.S.; Powell, D.; Goel, S. GE Consulting Services, Albany, NY )

    1992-02-01

    A new software system called Engineous combines artificial intelligence and numerical methods for the design and optimization of complex aerospace systems. Engineous combines the advanced computational techniques of genetic algorithms, expert systems, and object-oriented programming with the conventional methods of numerical optimization and simulated annealing to create a design optimization environment that can be applied to computational models in various disciplines. Engineous has produced designs with higher predicted performance gains that current manual design processes - on average a 10-to-1 reduction of turnaround time - and has yielded new insights into product design. It has been applied to the aerodynamic preliminary design of an aircraft engine turbine, concurrent aerodynamic and mechanical preliminary design of an aircraft engine turbine blade and disk, a space superconductor generator, a satellite power converter, and a nuclear-powered satellite reactor and shield. 23 refs.

  8. An integrated bioimpedance—ECG gating technique for respiratory and cardiac motion compensation in cardiac PET

    NASA Astrophysics Data System (ADS)

    Koivumäki, Tuomas; Nekolla, Stephan G.; Fürst, Sebastian; Loher, Simone; Vauhkonen, Marko; Schwaiger, Markus; Hakulinen, Mikko A.

    2014-10-01

    Respiratory motion may degrade image quality in cardiac PET imaging. Since cardiac PET studies often involve cardiac gating by ECG, a separate respiratory monitoring system is required increasing the logistic complexity of the examination, in case respiratory gating is also needed. Thus, we investigated the simultaneous acquisition of both respiratory and cardiac gating signals using II limb lead mimicking electrode configuration during cardiac PET scans of 11 patients. In addition to conventional static and ECG-gated images, bioimpedance technique was utilized to generate respiratory- and dual-gated images. The ability of the bioimpedance technique to monitor intrathoracic respiratory motion was assessed estimating cardiac displacement between end-inspiration and -expiration. The relevance of dual gating was evaluated in left ventricular volume and myocardial wall thickness measurements. An average 7.6  ±  3.3 mm respiratory motion was observed in the study population. Dual gating showed a small but significant increase (4 ml, p = 0.042) in left ventricular myocardial volume compared to plain cardiac gating. In addition, a thinner myocardial wall was observed in dual-gated images (9.3  ±  1.3 mm) compared to cardiac-gated images (11.3  ±  1.3 mm, p = 0.003). This study shows the feasibility of bioimpedance measurements for dual gating in a clinical setting. The method enables simultaneous acquisition of respiratory and cardiac gating signals using a single device with standard ECG electrodes.

  9. Integrated adsorptive technique for efficient recovery of m-cresol and m-toluidine from actual acidic and salty wastewater.

    PubMed

    Chen, Da; Liu, Fuqiang; Zong, Lidan; Sun, Xiaowen; Zhang, Xiaopeng; Zhu, Changqing; Tao, Xuewen; Li, Aimin

    2016-07-15

    An integrated adsorptive technique combining an m-cresol adsorption unit, an acid retardation unit and an m-toluidine adsorption unit in sequence was designed to recover m-cresol and m-toluidine from highly acidic and salty m-cresol manufacturing wastewater. In the first column packed with hypercrosslinked polymeric resin (NDA-99), most m-cresol was captured through π-π and hydrogen-bonding interactions as well as the salting-out effect, while m-toluidine was not absorbed due to protonation. To separate acid from salt, an acid retardation unit was introduced successively to adsorb sulfuric acid by strong base anion exchange resin (201×7). After the acid retardation unit and mild neutralization reaction, the last column filled with NDA-99 was applied to trap neutral m-toluidine from the salty effluent. Moreover, the eluent of the acid retardation unit was utilized as the regenerant to recover m-toluidine, and the recycled high-acidity and low-salinity solution of m-toluidine was directly used to produce m-cresol as the raw material. Therefore, the proposed method not only efficiently recycled m-cresol and m-toluidine, but also reduced the consumption of alkali dramatically (saving 0.1628t/t wastewater). These findings will inspire design of integrated adsorptive techniques for treating complex organic wastewater with high efficiency and low cost. PMID:27037473

  10. Extension of the broadband single-mode integrated optical waveguide technique to the ultraviolet spectral region and its applications.

    PubMed

    Wiederkehr, Rodrigo S; Mendes, Sergio B

    2014-03-21

    We report here the fabrication, characterization, and application of a single-mode integrated optical waveguide (IOW) spectrometer capable of acquiring optical absorbance spectra of surface-immobilized molecules in the visible and ultraviolet spectral region down to 315 nm. The UV-extension of the single-mode IOW technique to shorter wavelengths was made possible by our development of a low-loss single-mode dielectric waveguide in the UV region based on an alumina film grown by atomic layer deposition (ALD) over a high quality fused silica substrate, and by our design/fabrication of a broadband waveguide coupler formed by an integrated diffraction grating combined with a highly anamorphic optical beam of large numerical aperture. As an application of the developed technology, we report here the surface adsorption process of bacteriochlorophyll a on different interfaces using its Soret absorption band centred at 370 nm. The effects of different chemical compositions at the solid-liquid interface on the adsorption and spectral properties of bacteriochlorophyll a were determined from the polarized UV-Vis IOW spectra acquired with the developed instrumentation. The spectral extension of the single-mode IOW technique into the ultraviolet region is an important advance as it enables extremely sensitive studies in key characteristics of surface molecular processes (e.g., protein unfolding and solvation of aromatic amino-acid groups under surface binding) whose spectral features are mainly located at wavelengths below the visible spectrum.

  11. Integrating machine learning techniques and high-resolution imagery to generate GIS-ready information for urban water consumption studies

    NASA Astrophysics Data System (ADS)

    Wolf, Nils; Hof, Angela

    2012-10-01

    Urban sprawl driven by shifts in tourism development produces new suburban landscapes of water consumption on Mediterranean coasts. Golf courses, ornamental, 'Atlantic' gardens and swimming pools are the most striking artefacts of this transformation, threatening the local water supply systems and exacerbating water scarcity. In the face of climate change, urban landscape irrigation is becoming increasingly important from a resource management point of view. This paper adopts urban remote sensing towards a targeted mapping approach using machine learning techniques and highresolution satellite imagery (WorldView-2) to generate GIS-ready information for urban water consumption studies. Swimming pools, vegetation and - as a subgroup of vegetation - turf grass are extracted as important determinants of water consumption. For image analysis, the complex nature of urban environments suggests spatial-spectral classification, i.e. the complementary use of the spectral signature and spatial descriptors. Multiscale image segmentation provides means to extract the spatial descriptors - namely object feature layers - which can be concatenated at pixel level to the spectral signature. This study assesses the value of object features using different machine learning techniques and amounts of labeled information for learning. The results indicate the benefit of the spatial-spectral approach if combined with appropriate classifiers like tree-based ensembles or support vector machines, which can handle high dimensionality. Finally, a Random Forest classifier was chosen to deliver the classified input data for the estimation of evaporative water loss and net landscape irrigation requirements.

  12. Selective epitaxial growth techniques to integrate high-quality germanium on silicon

    NASA Astrophysics Data System (ADS)

    Leonhardt, Darin

    2011-12-01

    High-quality Ge-on-Si heterostructures have been actively pursued for many advanced applications, including near-infrared photodetectors, high-mobility field effect transistors, and virtual substrates for integrating III-V multijunction solar cells. However, growing epitaxial Ge on Si poses many engineering challenges, ranging from lattice mismatch, to thermal expansion coefficient mismatch, to non-planar morphological evolution. The lattice mismatch between Ge and Si often leads to a high density of threading dislocations. These dislocations, if not reduced, propagate through the subsequently grown GaAs layer, deteriorating its quality. To overcome these engineering challenges, we have developed three different approaches based on molecular beam epitaxy to significantly reduce, manage, or eliminate the defects in Ge films grown on Si. The first approach involves the nucleation of Ge islands within nanoscale windows in a thin layer of chemically grown SiO2 and successive island coalescence over the SiO2 to form a continuous film. Nanoscale contact areas between Ge and Si effectively relieve the lattice mismatch stress between Ge/Si so that dislocations do not nucleate. We observe that annealing the nucleated islands prior to full coalescence also leads to Ge films that are free of defects, along with significant improvement in GaAs integrated on Ge. The second approach involves trapping dislocations in Ge between high aspect ratio walls of SiO2. Defects form during coalescence of Ge from adjacent channels and at the corners of the SiO2 walls due to stress resulting from differences in thermal expansion coefficients of Ge, Si, and SiO2. The third approach involves filling etch pits, which reveal dislocations, with SiO2 and subsequent Ge growth over SiO2. The filling prevents dislocations in the lower Ge layer from propagating into the upper Ge layer. The third method reduces the defect density from 2.8 x 108 cm-2 to 9.1 x 10 6 cm-2, and is proven to be the most

  13. Derivatization technique to increase the spectral selectivity of two-dimensional Fourier transform infrared focal plane array imaging: analysis of binder composition in aged oil and tempera paint.

    PubMed

    Zumbühl, Stefan; Scherrer, Nadim C; Eggenberger, Urs

    2014-01-01

    The interpretation of standard Fourier transform infrared spectra (FT-IR) on oil-based paint samples often suffers from interfering bands of the different compounds, namely, binder, oxidative aging products, carboxylates formed during aging, and several pigments and fillers. The distinction of the aging products such as ketone and carboxylic acid functional groups pose the next problem, as these interfere with the triglyceride esters of the oil. A sample preparation and derivatization technique using gaseous sulfur tetrafluoride (SF4), was thus developed with the aim to discriminate overlapping signals and achieve a signal enhancement on superposed compounds. Of particular interest in this context is the signal elimination of the broad carboxylate bands of the typical reaction products developing during the aging processes in oil-based paints, as well as signal interference originating from several typical pigments in this spectral range. Furthermore, it is possible to distinguish the different carbonyl-containing functional groups upon selective alteration. The derivatization treatment can be applied to both microsamples and polished cross sections. It increases the selectivity of the infrared spectroscopy technique in a fundamental manner and permits the identification and two-dimensional (2D) localization of binder components in aged paint samples at the micrometer scale. The combination of SF4 derivatization with high-resolution 2D FT-IR focal plane array (FPA) imaging delivers considerable advances to the study of micro-morphological processes involving organic compounds.

  14. Assessment of natural radioactivity and function of minerals in soils of Yelagiri hills, Tamilnadu, India by Gamma Ray spectroscopic and Fourier Transform Infrared (FTIR) techniques with statistical approach.

    PubMed

    Chandrasekaran, A; Ravisankar, R; Rajalakshmi, A; Eswaran, P; Vijayagopal, P; Venkatraman, B

    2015-02-01

    Gamma Ray and Fourier Transform Infrared (FTIR) spectroscopic techniques were used to evaluate the natural radioactivity due to natural radionuclides and mineralogical characterization in soils of Yelagiri hills, Tamilnadu, India. Various radiological parameters were calculated to assess the radiation hazards associated with the soil. The distribution pattern of activity due to natural radionuclides is explained by Kriging method of mapping. Using FTIR spectroscopic technique the minerals such as quartz, microcline feldspar, orthoclase feldspar, kaolinite, montmorillonite, illite, and organic carbon were identified and characterized. The extinction coefficient values were calculated to know the relative distribution of major minerals such as quartz, microcline feldspar, orthoclase feldspar and kaolinite. The calculated values indicate that the amount of quartz is higher than orthoclase feldspar, microcline feldspar and much higher than kaolinite. Crystallinity index was calculated to know the crystalline nature of quartz. The result indicates that the presence of disordered crystalline quartz in soils. The relation between minerals and radioactivity was assessed by multivariate statistical analysis (Pearson's correlation and cluster analysis). The statistical analysis confirms that the clay mineral kaolinite and non-clay mineral quartz is the major factor than other major minerals to induce the important radioactivity variables and concentrations of uranium and thorium.

  15. Assessment of natural radioactivity and function of minerals in soils of Yelagiri hills, Tamilnadu, India by Gamma Ray spectroscopic and Fourier Transform Infrared (FTIR) techniques with statistical approach

    NASA Astrophysics Data System (ADS)

    Chandrasekaran, A.; Ravisankar, R.; Rajalakshmi, A.; Eswaran, P.; Vijayagopal, P.; Venkatraman, B.

    2015-02-01

    Gamma Ray and Fourier Transform Infrared (FTIR) spectroscopic techniques were used to evaluate the natural radioactivity due to natural radionuclides and mineralogical characterization in soils of Yelagiri hills, Tamilnadu, India. Various radiological parameters were calculated to assess the radiation hazards associated with the soil. The distribution pattern of activity due to natural radionuclides is explained by Kriging method of mapping. Using FTIR spectroscopic technique the minerals such as quartz, microcline feldspar, orthoclase feldspar, kaolinite, montmorillonite, illite, and organic carbon were identified and characterized. The extinction coefficient values were calculated to know the relative distribution of major minerals such as quartz, microcline feldspar, orthoclase feldspar and kaolinite. The calculated values indicate that the amount of quartz is higher than orthoclase feldspar, microcline feldspar and much higher than kaolinite. Crystallinity index was calculated to know the crystalline nature of quartz. The result indicates that the presence of disordered crystalline quartz in soils. The relation between minerals and radioactivity was assessed by multivariate statistical analysis (Pearson's correlation and cluster analysis). The statistical analysis confirms that the clay mineral kaolinite and non-clay mineral quartz is the major factor than other major minerals to induce the important radioactivity variables and concentrations of uranium and thorium.

  16. Advanced stored waveform inverse Fourier transform technique for a matrix-assisted laser desorption/ionization quadrupole ion trap mass spectrometer.

    PubMed

    Doroshenko, V M; Cotter, R J

    1996-01-01

    The stored waveform inverse Fourier transform (SWIFT) technique is used for broadband excitation of ions in an ion-trap mass spectrometer to perform mass-selective accumulation, isolation, and fragmentation of peptide ions formed by matrix-assisted laser desorption/ionization. Unit mass resolution is achieved for isolation of ions in the range of m/z up to 1300 using a two-step isolation technique with stretched-in-time narrow band SWIFT pulses at the second stage. The effect of 'stretched-in-time' waveforms is similar to that observed previously for mass-scan-rate reduction. The asymmetry phenomenon resulting from the stretched ion-trap electrode geometry is observed during application of normal and time-reversed waveforms and is similar to the asymmetry effects observed for forward and reverse mass scans in the resonance ejection mode. Mass-selective accumulation of ions from multiple laser shots was accomplished using a method described earlier that involves increasing the trapping voltage during ion introduction for more efficient trapping of ions.

  17. Proportional-integral and proportional-integral-derivative-based cyclic sleep controllers with anti-windup technique for energy-efficient and delay-aware passive optical networks

    NASA Astrophysics Data System (ADS)

    Kikuchi, Takahiro; Kubo, Ryogo

    2016-08-01

    In energy-efficient passive optical network (PON) systems, the increase in the queuing delays caused by the power-saving mechanism of optical network units (ONUs) is an important issue. Some researchers have proposed quality-of-service (QoS)-aware ONU cyclic sleep controllers in PON systems. We have proposed proportional (P) and proportional-derivative (PD)-based controllers to maintain the average queuing delay at a constant level regardless of the amount of downstream traffic. However, sufficient performance has not been obtained because of the sleep period limitation. In this paper, proportional-integral (PI) and proportional-integral-derivative (PID)-based controllers considering the sleep period limitation, i.e., using an anti-windup (AW) technique, are proposed to improve both the QoS and power-saving performance. Simulations confirm that the proposed controllers provide better performance than conventional controllers in terms of the average downstream queuing delay and the time occupancy of ONU active periods.

  18. Microsphere integrated microfluidic disk: synergy of two techniques for rapid and ultrasensitive dengue detection

    PubMed Central

    Hosseini, Samira; Aeinehvand, Mohammad M.; Uddin, Shah M.; Benzina, Abderazak; Rothan, Hussin A.; Yusof, Rohana; Koole, Leo H.; Madou, Marc J.; Djordjevic, Ivan; Ibrahim, Fatimah

    2015-01-01

    The application of microfluidic devices in diagnostic systems is well-established in contemporary research. Large specific surface area of microspheres, on the other hand, has secured an important position for their use in bioanalytical assays. Herein, we report a combination of microspheres and microfluidic disk in a unique hybrid platform for highly sensitive and selective detection of dengue virus. Surface engineered polymethacrylate microspheres with carefully designed functional groups facilitate biorecognition in a multitude manner. In order to maximize the utility of the microspheres’ specific surface area in biomolecular interaction, the microfluidic disk was equipped with a micromixing system. The mixing mechanism (microballoon mixing) enhances the number of molecular encounters between spheres and target analyte by accessing the entire sample volume more effectively, which subsequently results in signal amplification. Significant reduction of incubation time along with considerable lower detection limits were the prime motivations for the integration of microspheres inside the microfluidic disk. Lengthy incubations of routine analytical assays were reduced from 2 hours to 5 minutes while developed system successfully detected a few units of dengue virus. Obtained results make this hybrid microsphere-microfluidic approach to dengue detection a promising avenue for early detection of this fatal illness. PMID:26548806

  19. Microsphere integrated microfluidic disk: synergy of two techniques for rapid and ultrasensitive dengue detection

    NASA Astrophysics Data System (ADS)

    Hosseini, Samira; Aeinehvand, Mohammad M.; Uddin, Shah M.; Benzina, Abderazak; Rothan, Hussin A.; Yusof, Rohana; Koole, Leo H.; Madou, Marc J.; Djordjevic, Ivan; Ibrahim, Fatimah

    2015-11-01

    The application of microfluidic devices in diagnostic systems is well-established in contemporary research. Large specific surface area of microspheres, on the other hand, has secured an important position for their use in bioanalytical assays. Herein, we report a combination of microspheres and microfluidic disk in a unique hybrid platform for highly sensitive and selective detection of dengue virus. Surface engineered polymethacrylate microspheres with carefully designed functional groups facilitate biorecognition in a multitude manner. In order to maximize the utility of the microspheres’ specific surface area in biomolecular interaction, the microfluidic disk was equipped with a micromixing system. The mixing mechanism (microballoon mixing) enhances the number of molecular encounters between spheres and target analyte by accessing the entire sample volume more effectively, which subsequently results in signal amplification. Significant reduction of incubation time along with considerable lower detection limits were the prime motivations for the integration of microspheres inside the microfluidic disk. Lengthy incubations of routine analytical assays were reduced from 2 hours to 5 minutes while developed system successfully detected a few units of dengue virus. Obtained results make this hybrid microsphere-microfluidic approach to dengue detection a promising avenue for early detection of this fatal illness.

  20. Neutron intensity modulation and time-focusing with integrated Larmor and resonant frequency techniques

    SciTech Connect

    Zhao, Jinkui Hamilton, William A.; Robertson, J. L.; Crow, Lowell; Lee, Sung-Woo; Kang, Yoon W.

    2015-09-14

    The analysis of neutron diffraction experiments often assumes that neutrons are elastically scattered from the sample. However, there is growing evidence that a significant fraction of the detected neutrons is in fact inelastically scattered, especially from soft materials and aqueous samples. Ignoring these inelastic contributions gives rise to inaccurate experimental results. To date, there has been no simple method with broad applicability for inelastic signal separation in neutron diffraction experiments. Here, we present a simple and robust method that we believe could be suited for this purpose. We use two radio frequency resonant spin flippers integrated with a Larmor precession field to modulate the neutron intensity and to encode the inelastic scattering information into the neutron data. All three components contribute to the spin encoding. The Larmor field serves several additional purposes. Its usage facilitates neutron time-focusing, eliminates the need for stringent magnetic shielding, and allows for compact setups. The scheme is robust, simple, and flexible. We believe that, with further improvements, it has the potential of adding inelastic signal discrimination capabilities to many existing diffraction instruments in the future.

  1. Neutron intensity modulation and time-focusing with integrated Larmor and resonant frequency techniques

    NASA Astrophysics Data System (ADS)

    Zhao, Jinkui; Hamilton, William A.; Lee, Sung-Woo; Robertson, J. L.; Crow, Lowell; Kang, Yoon W.

    2015-09-01

    The analysis of neutron diffraction experiments often assumes that neutrons are elastically scattered from the sample. However, there is growing evidence that a significant fraction of the detected neutrons is in fact inelastically scattered, especially from soft materials and aqueous samples. Ignoring these inelastic contributions gives rise to inaccurate experimental results. To date, there has been no simple method with broad applicability for inelastic signal separation in neutron diffraction experiments. Here, we present a simple and robust method that we believe could be suited for this purpose. We use two radio frequency resonant spin flippers integrated with a Larmor precession field to modulate the neutron intensity and to encode the inelastic scattering information into the neutron data. All three components contribute to the spin encoding. The Larmor field serves several additional purposes. Its usage facilitates neutron time-focusing, eliminates the need for stringent magnetic shielding, and allows for compact setups. The scheme is robust, simple, and flexible. We believe that, with further improvements, it has the potential of adding inelastic signal discrimination capabilities to many existing diffraction instruments in the future.

  2. A novel, integrated PET-guided MRS technique resulting in more accurate initial diagnosis of high-grade glioma.

    PubMed

    Kim, Ellen S; Satter, Martin; Reed, Marilyn; Fadell, Ronald; Kardan, Arash

    2016-06-01

    Glioblastoma multiforme (GBM) is the most common and lethal malignant glioma in adults. Currently, the modality of choice for diagnosing brain tumor is high-resolution magnetic resonance imaging (MRI) with contrast, which provides anatomic detail and localization. Studies have demonstrated, however, that MRI may have limited utility in delineating the full tumor extent precisely. Studies suggest that MR spectroscopy (MRS) can also be used to distinguish high-grade from low-grade gliomas. However, due to operator dependent variables and the heterogeneous nature of gliomas, the potential for error in diagnostic accuracy with MRS is a concern. Positron emission tomography (PET) imaging with (11)C-methionine (MET) and (18)F-fluorodeoxyglucose (FDG) has been shown to add additional information with respect to tumor grade, extent, and prognosis based on the premise of biochemical changes preceding anatomic changes. Combined PET/MRS is a technique that integrates information from PET in guiding the location for the most accurate metabolic characterization of a lesion via MRS. We describe a case of glioblastoma multiforme in which MRS was initially non-diagnostic for malignancy, but when MRS was repeated with PET guidance, demonstrated elevated choline/N-acetylaspartate (Cho/NAA) ratio in the right parietal mass consistent with a high-grade malignancy. Stereotactic biopsy, followed by PET image-guided resection, confirmed the diagnosis of grade IV GBM. To our knowledge, this is the first reported case of an integrated PET/MRS technique for the voxel placement of MRS. Our findings suggest that integrated PET/MRS may potentially improve diagnostic accuracy in high-grade gliomas.

  3. Ultrasonic inspection technique for composite doubler/aluminum skin bond integrity for aircraft

    SciTech Connect

    Gieske, J.H.; Roach, D.P.; Walkington, P.D.

    1998-02-01

    As part of the FAA`s National Aging Aircraft Research Program to foster new technologies for civil aircraft maintenance and repair, use of bonded composite doublers on metal aircraft structures has been advanced. Research and validation of such doubler applications on US certified commercial aircraft has begun. A specific composite application to assess the capabilities of composite doublers was chosen on a L-1011 aircraft for reinforcement of the comer of a cargo door frame where a boron-epoxy repair patch of up to 72 plies was installed. A primary inspection requirement for these doublers is the identification of disbonds between the composite laminate and the aluminum parent material. This paper describes the development of an ultrasonic pulse echo technique using a modified immersion focus transducer where a robust signal amplitude signature of the composite aluminum interface is obtained to characterize the condition of the bond. Example waveforms and C-scan images are shown to illustrate the ultrasonic response for various transducer configurations using a boron-epoxy aluminum skin calibration test sample where disbonds and delaminations were built-in. The modified focus transducer is compatible with portable ultrasonic scanning systems that utilize the weeper or dripless bubbler technologies when an ultrasonic inspection of the boron-epoxy composite doublers installed on aircraft is implemented.

  4. Novel scanning electron microscope bulge test technique integrated with loading function

    SciTech Connect

    Li, Chuanwei; Xie, Huimin E-mail: xiehm@mail.tsinghua.edu.cn; Liu, Zhanwei E-mail: xiehm@mail.tsinghua.edu.cn

    2014-10-15

    Membranes and film-on-substrate structures are critical elements for some devices in electronics industry and for Micro Electro Mechanical Systems devices. These structures are normally at the scale of micrometer or even nanometer. Thus, the measurement for the mechanical property of these membranes poses a challenge over the conventional measurements at macro-scales. In this study, a novel bulge test method is presented for the evaluation of mechanical property of micro thin membranes. Three aspects are discussed in the study: (a) A novel bulge test with a Scanning Electron Microscope system realizing the function of loading and measuring simultaneously; (b) a simplified Digital Image Correlation method for a height measurement; and (c) an imaging distortion correction by the introduction of a scanning Moiré method. Combined with the above techniques, biaxial modulus as well as Young's modulus of the polyimide film can be determined. Besides, a standard tensile test is conducted as an auxiliary experiment to validate the feasibility of the proposed method.

  5. Integrated Analysis of the Wood Oil from Xanthocyparis vietnamensis Farjon & Hiep. by Chromatographic and Spectroscopic Techniques.

    PubMed

    Bazzali, Ophélie; Thai, Tran Huy; Hoi, Tran Minh; Khang, Nguyen Sinh; Hien, Nguyen Thi; Casanova, Joseph; Bighelli, Ange; Tomi, Félix

    2016-06-27

    In order to get better knowledge about the volatiles produced by Xanthocyparis vietnamensis, a species recently discovered in Vietnam, its wood oil has been analyzed by a combination of chromatographic (GC, CC) and spectroscopic (GC-MS, (13)C-NMR) techniques. Forty components that accounted for 87.9% of the oil composition have been identified. The composition is dominated by nootkatene (20.7%), 11,12,13-tri-nor-eremophil-1(10)-en-7-one (17.2%), γ-eudesmol (5.1%), nootkatone (4.7%), valencene (3.5%) and 13-nor-eremophil-1(10)-en-11-one (2.6%). The structure of two new compounds-10-epi-nor-γ-eudesmen-11-one and 12-hydroxy-isodihydroagarofuran-has been elucidated, while 11,12,13-tri-nor-eremophil-1(10)-en-7-ol is reported as a natural product for the first time. The composition of X. vietnamensis wood oil varied drastically from those of leaf oils, dominated by hedycaryol (34.4%), phyllocladene (37.8%) or by pimara-6(14)-15-diene (19.4%).

  6. Digital 3D Borobudur - Integration of 3D surveying and modeling techniques

    NASA Astrophysics Data System (ADS)

    Suwardhi, D.; Menna, F.; Remondino, F.; Hanke, K.; Akmalia, R.

    2015-08-01

    The Borobudur temple (Indonesia) is one of the greatest Buddhist monuments in the world, now listed as an UNESCO World Heritage Site. The present state of the temple is the result of restorations after being exposed to natural disasters several times. Today there is still a growing rate of deterioration of the building stones whose causes need further researches. Monitoring programs, supported at institutional level, have been effectively executed to observe the problem. The paper presents the latest efforts to digitally document the Borobudur Temple and its surrounding area in 3D with photogrammetric techniques. UAV and terrestrial images were acquired to completely digitize the temple, produce DEM, orthoimages and maps at 1:100 and 1:1000 scale. The results of the project are now employed by the local government organizations to manage the heritage area and plan new policies for the conservation and preservation of the UNESCO site. In order to help data management and policy makers, a web-based information system of the heritage area was also built to visualize and easily access all the data and achieved 3D results.

  7. Integrated Analysis of the Wood Oil from Xanthocyparis vietnamensis Farjon & Hiep. by Chromatographic and Spectroscopic Techniques.

    PubMed

    Bazzali, Ophélie; Thai, Tran Huy; Hoi, Tran Minh; Khang, Nguyen Sinh; Hien, Nguyen Thi; Casanova, Joseph; Bighelli, Ange; Tomi, Félix

    2016-01-01

    In order to get better knowledge about the volatiles produced by Xanthocyparis vietnamensis, a species recently discovered in Vietnam, its wood oil has been analyzed by a combination of chromatographic (GC, CC) and spectroscopic (GC-MS, (13)C-NMR) techniques. Forty components that accounted for 87.9% of the oil composition have been identified. The composition is dominated by nootkatene (20.7%), 11,12,13-tri-nor-eremophil-1(10)-en-7-one (17.2%), γ-eudesmol (5.1%), nootkatone (4.7%), valencene (3.5%) and 13-nor-eremophil-1(10)-en-11-one (2.6%). The structure of two new compounds-10-epi-nor-γ-eudesmen-11-one and 12-hydroxy-isodihydroagarofuran-has been elucidated, while 11,12,13-tri-nor-eremophil-1(10)-en-7-ol is reported as a natural product for the first time. The composition of X. vietnamensis wood oil varied drastically from those of leaf oils, dominated by hedycaryol (34.4%), phyllocladene (37.8%) or by pimara-6(14)-15-diene (19.4%). PMID:27355937

  8. Integrated GRASS GIS based techniques to identify thermal anomalies on water surface. Taranto case study.

    NASA Astrophysics Data System (ADS)

    Massarelli, Carmine; Matarrese, Raffaella; Felice Uricchio, Vito

    2014-05-01

    , graphics and maps production, spatial modeling, and visualization. In this study, we used three GRASS modules: r.clump, r.contour and v.generalize. The first module recategorizes data by grouping cells in discrete areas into a unique category preserving category distinctions in the input raster map layer. R.contour transforms an input surface raster data into an isolines vector data. The third module simplifies and smoothes the lines, reducing the complexity of vector features. As result, we produced a map of thermal anomalies around the coast surprisingly coincident with the inflows detected during the survey. Furthermore, the use of airborne images allowed us to identify other discharges in areas impossible to reach with the boat, due to the presence of algae, mussel-culture or forbidden military zones. With this study we demonstrated how it is possible to use GRASS GIS modules in a new combination in order to process remote sensed data achieving the same results of the expensive and complex specialized softwares. This work was funded by Regional Agency for Environmental Protection and Prevention in the Puglia region (ARPA Puglia).

  9. Further studies to extend and test the area-time-integral technique applied to satellite data

    NASA Technical Reports Server (NTRS)

    Smith, Paul L.; Vonderhaar, Thomas H.

    1993-01-01

    The principal goal of this project is to establish relationships that would allow application of area-time integral (ATI) calculations based upon satellite data to estimate rainfall volumes. The research has been pursued using two different approaches, which for convenience can be designated as the 'fixed-threshold approach' and the 'variable-threshold approach'. In the former approach, an attempt is made to determine a single temperature threshold in the satellite infrared data that would yield ATI values for identifiable cloud clusters which are most closely related to the corresponding rainfall amounts. Results thus far have indicated that a strong correlation exists between the rain volumes and the satellite ATI values, but the optimum threshold for this relationship seems to differ from one geographic location to another. The difference is probably related to differences in the basic precipitation mechanisms that dominate in the different regions. The average rainfall rate associated with each cloudy pixel is also found to vary across the spectrum of ATI values. Work on the second, or 'variable-threshold', approach for determining the satellite ATI values was essentially suspended during this period due to exhaustion of project funds. Most of the ATI work thus far has dealt with cloud clusters from the Lagrangian or 'floating-target' point of view. For many purposes, however, the Eulerian or 'fixed-target' perspective is more appropriate. For a very large target area encompassing entire cluster life histories, the rain volume-ATI relationship would obviously be the same in either case. The important question for the Eulerian perspective is how small the fixed area can be made while maintaining consistency in that relationship.

  10. Monitoring solute fluxes: Integrating electrical resistivity with multi-compartment sampler techniques

    NASA Astrophysics Data System (ADS)

    Bloem, Esther; Fernandez, Perrine; French, Helen K.

    2016-04-01

    The impact of agriculture, industry, airport activities on soil and water quality is strongly influenced by soil heterogeneity. To improve risk assessment, monitoring, and treatment strategies, we require a better understanding of the effect of soil heterogeneity on contaminant movement and better methods for monitoring heterogeneous contaminated transport. Sufficient characterization of spatial and temporal distribution of contaminant transport requires measurements of water and solute fluxes at multiple locations with a high temporal resolution. During this presentation, we will show a newly developed instrument, which combines multi-compartment sampling with electrical resistivity measurements, to observe spatial and temporal fluxes of contaminants. Solute monitoring is often limited to observations of resident concentrations, while flux concentrations govern the movement of solutes in soils. Bloem et al. (2010) developed a multi-compartment sampler (MCS) which is capable of measuring fluxes at a high spatial resolution under natural conditions. The sampler is divided into 100 separate compartments of 31 by 31 mm. Flux data can be recorded at a high time resolution (every 5 minutes). Tracer leaching can be monitored by frequently sampling the collected leachate while leaving the sampler buried in situ. To optimize the monitoring of tracer leaching and measure real solute fluxes the multi-compartment sampler has been extended with 121 electrodes. The electrodes are mounted at each corner of each compartment to measure the electrical conductivity above each compartment while water percolates through the compartments. By using different electrode couples, the setup can also be used to image above the multi-compartment sampler. The instrument can be used for detailed studies both in the laboratory and in the field. For laboratory experiments a transparent column is used which fits perfect on top of the MCS. We present a selection of the integrated electrical

  11. Molecularly Imprinted Polymer Integrated with a Surface Acoustic Wave Technique for Detection of Sulfamethizole.

    PubMed

    Ayankojo, Akinrinade George; Tretjakov, Aleksei; Reut, Jekaterina; Boroznjak, Roman; Öpik, Andres; Rappich, Jörg; Furchner, Andreas; Hinrichs, Karsten; Syritski, Vitali

    2016-01-19

    The synergistic effect of combining molecular imprinting and surface acoustic wave (SAW) technologies for the selective and label-free detection of sulfamethizole as a model antibiotic in aqueous environment was demonstrated. A molecularly imprinted polymer (MIP) for sulfamethizole (SMZ) selective recognition was prepared in the form of a homogeneous thin film on the sensing surfaces of SAW chip by oxidative electropolymerization of m-phenylenediamine (mPD) in the presence of SMZ, acting as a template. Special attention was paid to the rational selection of the functional monomer using computational and spectroscopic approaches. SMZ template incorporation and its subsequent release from the polymer was supported by IR microscopic measurements. Precise control of the thicknesses of the SMZ-MIP and respective nonimprinted reference films (NIP) was achieved by correlating the electrical charge dosage during electrodeposition with spectroscopic ellipsometry measurements in order to ensure accurate interpretation of label-free responses originating from the MIP modified sensor. The fabricated SMZ-MIP films were characterized in terms of their binding affinity and selectivity toward the target by analyzing the binding kinetics recorded using the SAW system. The SMZ-MIPs had SMZ binding capacity approximately more than eight times higher than the respective NIP and were able to discriminate among structurally similar molecules, i.e., sulfanilamide and sulfadimethoxine. The presented approach for the facile integration of a sulfonamide antibiotic-sensing layer with SAW technology allowed observing the real-time binding events of the target molecule at nanomolar concentration levels and could be potentially suitable for cost-effective fabrication of a multianalyte chemosensor for analysis of hazardous pollutants in an aqueous environment. PMID:26704414

  12. Molecularly Imprinted Polymer Integrated with a Surface Acoustic Wave Technique for Detection of Sulfamethizole.

    PubMed

    Ayankojo, Akinrinade George; Tretjakov, Aleksei; Reut, Jekaterina; Boroznjak, Roman; Öpik, Andres; Rappich, Jörg; Furchner, Andreas; Hinrichs, Karsten; Syritski, Vitali

    2016-01-19

    The synergistic effect of combining molecular imprinting and surface acoustic wave (SAW) technologies for the selective and label-free detection of sulfamethizole as a model antibiotic in aqueous environment was demonstrated. A molecularly imprinted polymer (MIP) for sulfamethizole (SMZ) selective recognition was prepared in the form of a homogeneous thin film on the sensing surfaces of SAW chip by oxidative electropolymerization of m-phenylenediamine (mPD) in the presence of SMZ, acting as a template. Special attention was paid to the rational selection of the functional monomer using computational and spectroscopic approaches. SMZ template incorporation and its subsequent release from the polymer was supported by IR microscopic measurements. Precise control of the thicknesses of the SMZ-MIP and respective nonimprinted reference films (NIP) was achieved by correlating the electrical charge dosage during electrodeposition with spectroscopic ellipsometry measurements in order to ensure accurate interpretation of label-free responses originating from the MIP modified sensor. The fabricated SMZ-MIP films were characterized in terms of their binding affinity and selectivity toward the target by analyzing the binding kinetics recorded using the SAW system. The SMZ-MIPs had SMZ binding capacity approximately more than eight times higher than the respective NIP and were able to discriminate among structurally similar molecules, i.e., sulfanilamide and sulfadimethoxine. The presented approach for the facile integration of a sulfonamide antibiotic-sensing layer with SAW technology allowed observing the real-time binding events of the target molecule at nanomolar concentration levels and could be potentially suitable for cost-effective fabrication of a multianalyte chemosensor for analysis of hazardous pollutants in an aqueous environment.

  13. Scaling filtering and multiplicative cascade information integration techniques for geological, geophysical and geochemical data processing and geological feature recognition

    NASA Astrophysics Data System (ADS)

    Cheng, Q.

    2013-12-01

    This paper introduces several techniques recently developed based on the concepts of multiplicative cascade processes and multifractals for processing exploration geochemical and geophysical data for recognition of geological features and delineation of target areas for undiscovered mineral deposits. From a nonlinear point of view extreme geo-processes such as cloud formation, rainfall, hurricanes, flooding, landslides, earthquakes, igneous activities, tectonics and mineralization often show singular property that they may result in anomalous amounts of energy release or mass accumulation that generally are confined to narrow intervals in space or time. The end products of these non-linear processes have in common that they can be modeled as fractals or multifractals. Here we show that the three fundamental concepts of scaling in the context of multifractals: singularity, self-similarity and fractal dimension spectrum, make multifractal theory and methods useful for geochemical and geophysical data processing for general purposes of geological features recognition. These methods include: a local singularity analysis based on a area-density (C-A) multifractal model used as a scaling high-pass filtering technique capable of extracting weak signals caused by buried geological features; a suite of multifractal filtering techniques based on spectrum density - area (S-A) multifractal models implemented in various domain including frequency domain can be used for unmixing geochemical or geophysical fields according to distinct generalized self-similarities characterized in certain domain; and multiplicative cascade processes for integration of diverse evidential layers of information for prediction of point events such as location of mineral deposits. It is demonstrated by several case studies involving Fe, Sn, Mo-Ag and Mo-W mineral deposits that singularity method can be utilized to process stream sediment/soil geochemical data and gravity/aeromagnetic data as high

  14. Analysis of effectiveness of three forest interventionist techniques and proposal of a new and integrated model of forest restoration.

    PubMed

    Castelli, Karen Regina; Barreto, Mariana Gregorio; Francesconi, Wendy; Dalla Valle, Leandro; Mondelli, Giulliana; Abilio, Fernanda Maria; da Silva, Alexandre Marco

    2015-01-01

    We assessed the efficacy of three different forest intervention techniques, in terms of phytosociological and edaphic responses, that were implemented in 2007. In a farm where trees are planted and managed for cellulose production as well as set aside for environmental conservation, four stands were analysed: three of them were considered degraded and were managed using different intervention techniques (transposition, perch, and abandonment), and a fourth stand comprising pristine vegetation was considered a control (reference). Floristic and phytosociology data were collected in three 10 × 10 m plots established in each stand. Also, a total of 48 soil samples were collected to analyse physical and chemical attributes of the topsoil for the different stands. In terms of biodiversity, all the treatments showed significantly lower values when compared to the reference area. However, the soils in all the treatment and reference stands are similar in terms of physical and chemical attributes. Taking into account the specificities of each restoration technique, we verified that the integrated use of a set of management practices, constituted by the (1) abandonment of the area and (2) following a selective killing of the eucalyptus, is the most suitable and promising model to provide fast and effective restoration in terms of environmental indicators.

  15. Integrating auxiliary data and geophysical techniques for the estimation of soil clay content using CHAID algorithm

    NASA Astrophysics Data System (ADS)

    Abbaszadeh Afshar, Farideh; Ayoubi, Shamsollah; Besalatpour, Ali Asghar; Khademi, Hossein; Castrignano, Annamaria

    2016-03-01

    This study was conducted to estimate soil clay content in two depths using geophysical techniques (Ground Penetration Radar-GPR and Electromagnetic Induction-EMI) and ancillary variables (remote sensing and topographic data) in an arid region of the southeastern Iran. GPR measurements were performed throughout ten transects of 100 m length with the line spacing of 10 m, and the EMI measurements were done every 10 m on the same transect in six sites. Ten soil cores were sampled randomly in each site and soil samples were taken from the depth of 0-20 and 20-40 cm, and then the clay fraction of each of sixty soil samples was measured in the laboratory. Clay content was predicted using three different sets of properties including geophysical data, ancillary data, and a combination of both as inputs to multiple linear regressions (MLR) and decision tree-based algorithm of Chi-Squared Automatic Interaction Detection (CHAID) models. The results of the CHAID and MLR models with all combined data showed that geophysical data were the most important variables for the prediction of clay content in two depths in the study area. The proposed MLR model, using the combined data, could explain only 0.44 and 0.31% of the total variability of clay content in 0-20 and 20-40 cm depths, respectively. Also, the coefficient of determination (R2) values for the clay content prediction, using the constructed CHAID model with the combined data, was 0.82 and 0.76 in 0-20 and 20-40 cm depths, respectively. CHAID models, therefore, showed a greater potential in predicting soil clay content from geophysical and ancillary data, while traditional regression methods (i.e. the MLR models) did not perform as well. Overall, the results may encourage researchers in using georeferenced GPR and EMI data as ancillary variables and CHAID algorithm to improve the estimation of soil clay content.

  16. Pathway of FeEDTA transformation and its impact on performance of NOx removal in a chemical absorption-biological reduction integrated process.

    PubMed

    Li, Wei; Zhao, Jingkai; Zhang, Lei; Xia, Yinfeng; Liu, Nan; Li, Sujing; Zhang, Shihan

    2016-01-01

    A novel chemical absorption-biological reduction (CABR) integrated process, employing ferrous ethylenediaminetetraacetate (Fe(II)EDTA) as a solvent, is deemed as a potential option for NOx removal from the flue gas. Previous work showed that the Fe(II)EDTA concentration was critical for the NOx removal in the CABR process. In this work, the pathway of FeEDTA (Fe(III)/Fe(II)-EDTA) transformation was investigated to assess its impact on the NOx removal in a biofilter. Experimental results revealed that the FeEDTA transformation involved iron precipitation and EDTA degradation. X-ray photoelectron spectroscopy analysis confirmed the iron was precipitated in the form of Fe(OH)3. The iron mass balance analysis showed 44.2% of the added iron was precipitated. The EDTA degradation facilitated the iron precipitation. Besides chemical oxidation, EDTA biodegradation occurred in the biofilter. The addition of extra EDTA helped recover the iron from the precipitation. The transformation of FeEDTA did not retard the NO removal. In addition, EDTA rather than the iron concentration determined the NO removal efficiency.

  17. Pathway of FeEDTA transformation and its impact on performance of NOx removal in a chemical absorption-biological reduction integrated process

    PubMed Central

    Li, Wei; Zhao, Jingkai; Zhang, Lei; Xia, Yinfeng; Liu, Nan; Li, Sujing; Zhang, Shihan

    2016-01-01

    A novel chemical absorption-biological reduction (CABR) integrated process, employing ferrous ethylenediaminetetraacetate (Fe(II)EDTA) as a solvent, is deemed as a potential option for NOx removal from the flue gas. Previous work showed that the Fe(II)EDTA concentration was critical for the NOx removal in the CABR process. In this work, the pathway of FeEDTA (Fe(III)/Fe(II)-EDTA) transformation was investigated to assess its impact on the NOx removal in a biofilter. Experimental results revealed that the FeEDTA transformation involved iron precipitation and EDTA degradation. X-ray photoelectron spectroscopy analysis confirmed the iron was precipitated in the form of Fe(OH)3. The iron mass balance analysis showed 44.2% of the added iron was precipitated. The EDTA degradation facilitated the iron precipitation. Besides chemical oxidation, EDTA biodegradation occurred in the biofilter. The addition of extra EDTA helped recover the iron from the precipitation. The transformation of FeEDTA did not retard the NO removal. In addition, EDTA rather than the iron concentration determined the NO removal efficiency. PMID:26743930

  18. Identification of photoproducts of fungicide cyprodinil and elucidation of transformation mechanism in water using LC-IT-TOF-MS/MS technique.

    PubMed

    Chen, Xiaoxin; Dong, Bizhang; Lin, Hongfang; Hu, Jiye

    2016-10-01

    This study aimed at investigating photodegradation of cyprodinil in aquatic solution under the simulated natural light or UV-visible irradiation (290-800 nm) using LC-MS/MS techniques. Effects of pH, nitrate ion, Fe (III), humic acid and TiO2 on photolysis kinetics of cyprodinil were explored. The photodegradation followed first-order reaction kinetics, and linear accelerating effects of Fe (III), nitrate ion and TiO2 with concentrations ranging from 0.1 to 5.0 mg L(-1) on photodegradation were remarkably observed. HA at low concentration ranges (<3.0 mg L(-1)) enhanced cyprodinil photodegradation while the photocatalytic rate was weakened with more addition of HA. The degradation rate in alkaline solutions was greater than in acidic solutions. Six main transformation products (TPs) were separated and identified based on mass spectra data and density functional theory (DFT) quantum calculations, and their kinetic evolutions were also investigated. Ultimately, a tentative transformation mechanism was proposed based the identified TPs and their kinetic evolutions. The results indicated that one α-H on pyridine ring of cyprodinil was hydroxylated to form TPs 1. TPs 1 underwent a series of photochemical reactions involving ring-opening, addition of one H2O molecule and demethylation on three-member ring to form TPs 2, which was further hydroxylated on benzene ring to form TPs 6. TPs 3-5 were three isomers from Hofmann-Martius rearrangement of cyprodinil. These findings were of utmost importance for elucidating environmental fate of cyprodinil in aquatic ecosystem and further environmental risk evaluation.

  19. Pleasure, Throwing Breaches, and Embodied Metaphors: Tracing Transformations-in-Participation for a Child With Autism to a Sensory Integration-Based Therapy Session.

    PubMed

    Park, Melissa

    2012-01-01

    In occupational therapy practice, the rich interweaving of procedural and narrative reasoning results in healing transformations. However, a lack of research focus on transformational processes perpetuates a focus on observable and measurable behaviors. In line with the movement toward evidence-based implementation research, this article focuses on a case study drawn from an ethnography of therapist-child-family interactions in a sensory integration-based clinic to provide a thick description of the moments leading up to and following changes in bodily and social engagement for a child with autism. Using theoretical resources on acted narratives and aesthetics, this article provides a developing method and language to show how an occupational therapist and a child with autism throw breaches to jointly create embodied metaphors of what matters to the child in his or her everyday life. A microanalysis of therapist-child bodily and sensing interactions also reveals how narrative and procedural reasoning converge in moments of pleasure that ultimately lead to outcomes in participation outside the clinic and confound characterizations of autistic aloneness. Implications for research on sensory integration approaches in general and social interventions for children with autism are discussed. PMID:24650787

  20. Integrating Novel Field, Laboratory and Modelling Techniques to Upscale Estimates of Soil Erosion

    NASA Astrophysics Data System (ADS)

    Wainwright, John; Parsons, Anthony; Cooper, James; Long, Edward; Hargrave, Graham; Kitchener, Ben; Hewett, Caspar; Onda, Yuichi; Furukawa, Tomomi; Obana, Eiichiro; Hayashi, Hirofumi; Noguchi, Takehiro

    2013-04-01

    Erosion is a particle-based phenomenon, yet most of current understanding and modelling of this process is based on bulk measurements rather than the movement of individual particles. Difficulties with measuring particle motions in dynamically changing conditions are being overcome with the application of two new technologies - particle imaging velocimetry (PIV) and radio frequency identification (RFID). It is thus possible to evaluate the entrainment, transport and deposition of individual particles and these data can be used to parameterize and to test particle-based modelling of the particle-based process. Both PIV and RFID tagging have been used in laboratory experiments to evaluate the detachment process by raindrops on bare surfaces and in shallow flows using rainfall simulation. The results suggest that the processes are more complex than hitherto thought with multiple detachment and transfer mechanisms. Because both mechanisms affect travel distance, they affect the ways in which estimates of soil erosion can be scaled from plot to hillslope and catchment scales. To evaluate movements at larger scales, we have also used RFID-tagged particles in field settings to look at sediment transfers following the Fukushima accident in Japan, 2011. A marker-in-cell model (MAHLERAN-MiC) has been developed to enable the laboratory results to be upscaled and tested in a field setting. Markers (representing sediment particles), containing sediment-property information, are initially distributed on a cellular grid. A cellular model is used to set up the boundary conditions and determine the hydrology and hydraulics on the hillslope. The markers are then moved through the grid according to these properties. This technique combines the advantages of Eulerian and Lagrangian methods while avoiding the shortcomings of each (computational efficiency vs. accuracy). The model simulates all the processes of detachment and transport; raindrop detachment and transport, interrill

  1. Inorganic nitrogen transformations in the bed of the Shingobee River, Minnesota: Integrating hydrologic and biological processes using sediment perfusion cores

    USGS Publications Warehouse

    Sheibley, R.W.; Duff, J.H.; Jackman, A.P.; Triska, F.J.

    2003-01-01

    Inorganic N transformations were examined in streambed sediments from the Shingobee River using sediment perfusion cores. The experimental design simulated groundwater-stream water mixing within sediment cores, which provided a well-defined one-dimensional representation of in situ hydrologic conditions. Two distinct hydrologic and chemical settings were preserved in the sediment cores: the lowermost sediments, perfused with groundwater, remained anaerobic during the incubations, whereas the uppermost sediments, perfused with oxic water pumped from the overlying water column, simulated stream water penetration into the bed. The maintenance of oxic and anoxic zones formed a biologically active aerobic-anaerobic interface. Ammonium (NH4+) dissolved in groundwater was transported conservatively through the lower core zone but was removed as it mixed with aerated recycle water. Concurrently, a small quantity of nitrate (NO3-) equaling ???25% of the NH4+ loss was produced in the upper sediments. The NH4+ and NO3- profiles in the uppermost sediments resulted from coupled nitrification-denitrification, because assimilation and sorption were negligible. We hypothesize that anaerobic microsites within the aerated upper sediments supported denitrification. Rates of nitrification and denitrification in the perfusion cores ranged 42-209 and 53-160 mg N m-2 day-1, respectively. The use of modified perfusion cores permitted the identification and quantification of N transformations and verified process control by surface water exchange into the shallow hyporheic zone of the Shingobee River.

  2. Exploratory Nuclear Reactor Safety Analysis and Visualization via Integrated Topological and Geometric Techniques

    SciTech Connect

    Dan Maljovec; Bei Wang; Valerio Pascucci; Peer-Timo Bremer; Diego Mandelli; Michael Pernice; Robert Nourgaliev

    2013-10-01

    A recent trend in the nuclear power engineering field is the implementation of heavily computational and time consuming algorithms and codes for both design and safety analysis. In particular, the new generation of system analysis codes aim to embrace several phenomena such as thermo-hydraulic, structural behavior, and system dynamics, as well as uncertainty quantification and sensitivity analyses. The use of dynamic probabilistic risk assessment (PRA) methodologies allows a systematic approach to uncertainty quantification. Dynamic methodologies in PRA account for possible coupling between triggered or stochastic events through explicit consideration of the time element in system evolution, often through the use of dynamic system models (simulators). They are usually needed when the system has more than one failure mode, control loops, and/or hardware/process/software/human interaction. Dynamic methodologies are also capable of modeling the consequences of epistemic and aleatory uncertainties. The Monte-Carlo (MC) and the Dynamic Event Tree (DET) approaches belong to this new class of dynamic PRA methodologies. The major challenges in using MC and DET methodologies (as well as other dynamic methodologies) are the heavier computational and memory requirements compared to the classical ET analysis. This is due to the fact that each branch generated can contain time evolutions of a large number of variables (about 50,000 data channels are typically present in RELAP) and a large number of scenarios can be generated from a single initiating event (possibly on the order of hundreds or even thousands). Such large amounts of information are usually very difficult to organize in order to identify the main trends in scenario evolutions and the main risk contributors for each initiating event. This report aims to improve Dynamic PRA methodologies by tackling the two challenges mentioned above using: 1) adaptive sampling techniques to reduce computational cost of the analysis

  3. Integration of FTTH and GI-POF in-house networks based on injection locking and direct-detection techniques.

    PubMed

    Peng, Hsiao-Chun; Lu, Hai-Han; Li, Chung-Yi; Su, Heng-Sheng; Hsu, Chin-Tai

    2011-03-28

    An integration of fiber-to-the-home (FTTH) and graded-index plastic optical fiber (GI-POF) in-house networks based on injection-locked vertical cavity surface emitting lasers (VCSELs) and direct-detection technique is proposed and experimentally demonstrated. Sufficient low bit error rate (BER) values were obtained over a combination of 20-km single-mode fiber (SMF) and 50-m GI-POF links. Signal qualities satisfy the worldwide interoperability for microwave access (WiMAX) requirement with data signals of 20 Mbps/5.8 GHz and 70 Mbps/10 GHz, respectively. Since our proposed network does not use sophisticated and expensive RF devices in premises, it reveals a prominent one with simpler and more economic advantages. Our proposed architecture is suitable for the SMF-based primary and GI-POF-based in-house networks. PMID:21451701

  4. Integration of FTTH and GI-POF in-house networks based on injection locking and direct-detection techniques.

    PubMed

    Peng, Hsiao-Chun; Lu, Hai-Han; Li, Chung-Yi; Su, Heng-Sheng; Hsu, Chin-Tai

    2011-03-28

    An integration of fiber-to-the-home (FTTH) and graded-index plastic optical fiber (GI-POF) in-house networks based on injection-locked vertical cavity surface emitting lasers (VCSELs) and direct-detection technique is proposed and experimentally demonstrated. Sufficient low bit error rate (BER) values were obtained over a combination of 20-km single-mode fiber (SMF) and 50-m GI-POF links. Signal qualities satisfy the worldwide interoperability for microwave access (WiMAX) requirement with data signals of 20 Mbps/5.8 GHz and 70 Mbps/10 GHz, respectively. Since our proposed network does not use sophisticated and expensive RF devices in premises, it reveals a prominent one with simpler and more economic advantages. Our proposed architecture is suitable for the SMF-based primary and GI-POF-based in-house networks.

  5. One hundred years after Sigmund Freud's lectures in America: towards an integration of psychoanalytic theories and techniques within psychiatry.

    PubMed

    Hoffman, Leon

    2010-12-01

    The impact of Sigmund Freud's lectures in America in 1909 is discussed. Some of the roots of psychoanalysis and their contemporary relevance are addressed: neurological ideas, the discussions of the sexologists, and the degeneration theories at the turn of the twentieth century. Factors which led to the dominance of psychoanalysis in psychiatry included, in particular, its arguments against the hopelessness of degeneracy theories;yet,by isolating itself from mainstream academic psychiatry and psychology,organized psychoanalysis itself contributed to its own subsequent marginalization. In order to re-integrate itself with mainstream psychiatry, psychoanalysis needs to appreciate the importance of systematic demonstrations of the therapeutic power of psychodynamic/psychoanalytic concepts and techniques when caring for individuals.

  6. Transformation of the integral integral F(r, r ', vertical bar(r)over-right-arrow-(r)over-right-arrow vertical bar) d(r)over-right-arrow d(r)over-right-arrow ' using Hylleraas coordinates in N-dimensions

    NASA Astrophysics Data System (ADS)

    Mukhopadhyay, S.; Chatterjee, A.

    2006-09-01

    The integral integral F(r, r', vertical bar r - r'vertical bar) dr dr' where r and r' are N-dimensional position vectors can be transformed into a simple three-dimensional integral using Hylleraas coordinates. A simple derivation of this result is presented.

  7. A simple, sensitive and non-destructive technique for characterizing bovine dental enamel erosion: attenuated total reflection Fourier transform infrared spectroscopy

    PubMed Central

    Kim, In-Hye; Son, Jun Sik; Min, Bong Ki; Kim, Young Kyoung; Kim, Kyo-Han; Kwon, Tae-Yub

    2016-01-01

    Although many techniques are available to assess enamel erosion in vitro, a simple, non-destructive method with sufficient sensitivity for quantifying dental erosion is required. This study characterized the bovine dental enamel erosion induced by various acidic beverages in vitro using attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. Deionized water (control) and 10 acidic beverages were selected to study erosion, and the pH and neutralizable acidity were measured. Bovine anterior teeth (110) were polished with up to 1 200-grit silicon carbide paper to produce flat enamel surfaces, which were then immersed in 20 mL of the beverages for 30 min at 37 °C. The degree of erosion was evaluated using ATR-FTIR spectroscopy and Vickers' microhardness measurements. The spectra obtained were interpreted in two ways that focused on the ν1, ν3 phosphate contour: the ratio of the height amplitude of ν3 PO4 to that of ν1 PO4 (Method 1) and the shift of the ν3 PO4 peak to a higher wavenumber (Method 2). The percentage changes in microhardness after the erosion treatments were primarily affected by the pH of the immersion media. Regression analyses revealed highly significant correlations between the surface hardness change and the degree of erosion, as detected by ATR-FTIR spectroscopy (P<0.001). Method 1 was the most sensitive to these changes, followed by surface hardness change measurements and Method 2. This study suggests that ATR-FTIR spectroscopy is potentially advantageous over the microhardness test as a simple, non-destructive, sensitive technique for the quantification of enamel erosion. PMID:27025266

  8. A simple, sensitive and non-destructive technique for characterizing bovine dental enamel erosion: attenuated total reflection Fourier transform infrared spectroscopy.

    PubMed

    Kim, In-Hye; Son, Jun Sik; Min, Bong Ki; Kim, Young Kyoung; Kim, Kyo-Han; Kwon, Tae-Yub

    2016-03-30

    Although many techniques are available to assess enamel erosion in vitro, a simple, non-destructive method with sufficient sensitivity for quantifying dental erosion is required. This study characterized the bovine dental enamel erosion induced by various acidic beverages in vitro using attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. Deionized water (control) and 10 acidic beverages were selected to study erosion, and the pH and neutralizable acidity were measured. Bovine anterior teeth (110) were polished with up to 1 200-grit silicon carbide paper to produce flat enamel surfaces, which were then immersed in 20 mL of the beverages for 30 min at 37 °C. The degree of erosion was evaluated using ATR-FTIR spectroscopy and Vickers' microhardness measurements. The spectra obtained were interpreted in two ways that focused on the ν1, ν3 phosphate contour: the ratio of the height amplitude of ν3 PO4 to that of ν1 PO4 (Method 1) and the shift of the ν3 PO4 peak to a higher wavenumber (Method 2). The percentage changes in microhardness after the erosion treatments were primarily affected by the pH of the immersion media. Regression analyses revealed highly significant correlations between the surface hardness change and the degree of erosion, as detected by ATR-FTIR spectroscopy (P<0.001). Method 1 was the most sensitive to these changes, followed by surface hardness change measurements and Method 2. This study suggests that ATR-FTIR spectroscopy is potentially advantageous over the microhardness test as a simple, non-destructive, sensitive technique for the quantification of enamel erosion.

  9. A simple, sensitive and non-destructive technique for characterizing bovine dental enamel erosion: attenuated total reflection Fourier transform infrared spectroscopy.

    PubMed

    Kim, In-Hye; Son, Jun Sik; Min, Bong Ki; Kim, Young Kyoung; Kim, Kyo-Han; Kwon, Tae-Yub

    2016-03-01

    Although many techniques are available to assess enamel erosion in vitro, a simple, non-destructive method with sufficient sensitivity for quantifying dental erosion is required. This study characterized the bovine dental enamel erosion induced by various acidic beverages in vitro using attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. Deionized water (control) and 10 acidic beverages were selected to study erosion, and the pH and neutralizable acidity were measured. Bovine anterior teeth (110) were polished with up to 1 200-grit silicon carbide paper to produce flat enamel surfaces, which were then immersed in 20 mL of the beverages for 30 min at 37 °C. The degree of erosion was evaluated using ATR-FTIR spectroscopy and Vickers' microhardness measurements. The spectra obtained were interpreted in two ways that focused on the ν1, ν3 phosphate contour: the ratio of the height amplitude of ν3 PO4 to that of ν1 PO4 (Method 1) and the shift of the ν3 PO4 peak to a higher wavenumber (Method 2). The percentage changes in microhardness after the erosion treatments were primarily affected by the pH of the immersion media. Regression analyses revealed highly significant correlations between the surface hardness change and the degree of erosion, as detected by ATR-FTIR spectroscopy (P<0.001). Method 1 was the most sensitive to these changes, followed by surface hardness change measurements and Method 2. This study suggests that ATR-FTIR spectroscopy is potentially advantageous over the microhardness test as a simple, non-destructive, sensitive technique for the quantification of enamel erosion. PMID:27025266

  10. Intensity moments by path integral techniques for wave propagation through random media, with application to sound in the ocean

    NASA Technical Reports Server (NTRS)

    Bernstein, D. R.; Dashen, R.; Flatte, S. M.

    1983-01-01

    A theory is developed which describes intensity moments for wave propagation through random media. It is shown using the path integral technique that these moments are significantly different from those of a Rayleigh distribution in certain asymptotic regions. The path integral approach is extended to inhomogeneous, anisotropic media possessing a strong deterministic velocity profile. The behavior of the corrections to Rayleigh statistics is examined, and it is shown that the important characteristics can be attributed to a local micropath focusing function. The correction factor gamma is a micropath focusing parameter defined in terms of medium fluctuations. The value of gamma is calculated for three ocean acoustic experiments, using internal waves as the medium fluctuations. It is found that all three experiments show excellent agreement as to the relative values of the intensity moments. The full curved ray is found to yield results that are significantly different from the straight-line approximations. It is noted that these methods are applicable to a variety of experimental situations, including atmospheric optics and radio waves through plasmas.

  11. Integration of airborne Thematic Mapper Simulator (TMS) data and digitized aerial photography via an ISH transformation. [Intensity Saturation Hue

    NASA Technical Reports Server (NTRS)

    Ambrosia, Vincent G.; Myers, Jeffrey S.; Ekstrand, Robert E.; Fitzgerald, Michael T.

    1991-01-01

    A simple method for enhancing the spatial and spectral resolution of disparate data sets is presented. Two data sets, digitized aerial photography at a nominal spatial resolution 3,7 meters and TMS digital data at 24.6 meters, were coregistered through a bilinear interpolation to solve the problem of blocky pixel groups resulting from rectification expansion. The two data sets were then subjected to intensity-saturation-hue (ISH) transformations in order to 'blend' the high-spatial-resolution (3.7 m) digitized RC-10 photography with the high spectral (12-bands) and lower spatial (24.6 m) resolution TMS digital data. The resultant merged products make it possible to perform large-scale mapping, ease photointerpretation, and can be derived for any of the 12 available TMS spectral bands.

  12. Transformation system for Hypocrea jecorina (Trichoderma reesei) that favors homologous integration and employs reusable bidirectionally selectable markers.

    PubMed

    Steiger, Matthias G; Vitikainen, Marika; Uskonen, Pekka; Brunner, Kurt; Adam, Gerhard; Pakula, Tiina; Penttilä, Merja; Saloheimo, Markku; Mach, Robert L; Mach-Aigner, Astrid R

    2011-01-01

    Hypocrea jecorina is an industrially important filamentous fungus due to its effective production of hydrolytic enzymes. It has received increasing interest because of its ability to convert lignocellulosic biomass to monomeric sugars, which can be converted into biofuels or platform chemicals. Genetic engineering of strains is a highly important means of meeting the requirements of tailor-made applications. Therefore, we report the development of a transformation system that allows highly efficient gene targeting by using a tmus53 (human LIG4 homolog) deletion strain. Moreover, it permits the unlimited reuse of the same marker by employing a Cre/loxP-based excision system. Both marker insertion and marker excision can be positively selected for by combining resistance to hygromycin B and loss of sensitivity to fluoroacetamide. Finally, the marker pyr4, also positively selectable for insertion and loss, can be used to remove the cre gene.

  13. Fourier transform infrared photoacoustic spectroscopy study of physicochemical interaction between human dentin and etch-&-rinse adhesives in a simulated moist bond technique.

    PubMed

    Ubaldini, Adriana L M; Baesso, Mauro L; Sehn, Elizandra; Sato, Francielle; Benetti, Ana R; Pascotto, Renata C

    2012-06-01

    The purpose of this study was to provide the physicochemical interactions at the interfaces between two commercial etch-&-rinse adhesives and human dentin in a simulated moist bond technique. Six dentin specimens were divided into two groups (n=3) according to the use of two different adhesive systems: (a) 2-hydroxyethylmethacrylate (HEMA) and 4-methacryloxyethyl trimellitate anhydrate (4-META), and (b) HEMA. The Fourier transform infrared photoacoustic spectroscopy was performed before and after dentin treatment with 37% phosphoric acid, with adhesive systems and also for the adhesive systems alone. Acid-conditioning resulted in a decalcification pattern. Adhesive treated spectra subtraction suggested the occurrence of chemical bonding to dentin expressed through modifications of the OH stretching peak (3340 cm(-1)) and symmetric CH stretching (2900 cm(-1)) for both adhesives spectra; a decrease of orthophosphate absorption band (1040 to 970 cm(-1)) for adhesive A and a better resolved complex band formation (1270 to 970 cm(-1)) for adhesive B were observed. These results suggested the occurrence of chemical bonding between sound human dentin and etch-&-rinse adhesives through a clinical typical condition.

  14. Measuring temperature-dependent propagating disturbances in coronal fan loops using multiple SDO/AIA channels and the surfing transform technique

    SciTech Connect

    Uritsky, Vadim M.; Ofman, Leon; Davila, Joseph M.; Viall, Nicholeen M.

    2013-11-20

    A set of co-aligned high-resolution images from the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory is used to investigate propagating disturbances (PDs) in warm fan loops at the periphery of a non-flaring active region NOAA AR 11082. To measure PD speeds at multiple coronal temperatures, a new data analysis methodology is proposed enabling a quantitative description of subvisual coronal motions with low signal-to-noise ratios of the order of 0.1%. The technique operates with a set of one-dimensional 'surfing' signals extracted from position-time plots of several AIA channels through a modified version of Radon transform. The signals are used to evaluate a two-dimensional power spectral density distribution in the frequency-velocity space that exhibits a resonance in the presence of quasi-periodic PDs. By applying this analysis to the same fan loop structures observed in several AIA channels, we found that the traveling velocity of PDs increases with the temperature of the coronal plasma following the square-root dependence predicted for slow mode magneto-acoustic waves which seem to be the dominating wave mode in the loop structures studied. This result extends recent observations by Kiddie et al. to a more general class of fan loop system not associated with sunspots and demonstrating consistent slow mode activity in up to four AIA channels.

  15. A novel hybrid patterning technique for micro and nanochannel fabrication by integrating hot embossing and inverse UV photolithography.

    PubMed

    Yin, Zhifu; Cheng, E; Zou, Helin

    2014-05-01

    Nanofluidic devices with micro and nanostructures are becoming increasingly important for biological and chemical applications. However, the majority of the present fabrication methods suffer from a low pattern transfer quality during the simultaneous embossing of the microscale and nanoscale patterns into a thermoplastic polymer due to insufficient polymer flow. In this work, a novel hybrid patterning technique, integrating hot embossing and inverse ultraviolet (UV) photolithography, is developed to fabricate micro and nanochannels with a high replication precision of the SU-8 layer. The influence of embossing temperature and time on the replication precision was investigated. The effect of UV lithography parameters on the micro and nanochannel pattern was analyzed. To improve the SU-8 bonding strength, the influence of the O2 plasma treatment parameters on the water contact angles of the exposed and unexposed SU-8 layer were studied. A complete SU-8 nanofluidic chip with 130 nm wide and 150 nm deep nanochannels was successfully fabricated with a replication precision of 99.5%. Compared with most of the current processing methods, this fabrication technique has great potential due to its low cost and high pattern transfer quality of the SU-8 micro and nanochannels.

  16. Optical properties of albino rat skin heated in vitro: comparison of photoacoustic and integrating sphere measurement techniques

    NASA Astrophysics Data System (ADS)

    Thomsen, Sharon L.; Vijverberg, Helene; Jacques, Steven L.; Oraevsky, Alexander A.

    1994-08-01

    The optical properties represented by the absorption coefficient ((mu) a) and reduced scattering coefficient [(mu) s(1-g) or (mu) 's] at (lambda) equals 355 nm of thermally altered albino rat skin were measured in vitro by two methods: (1) a time-resolved stress detection (TRSD) technique which directly measured the effective attenuation coefficient ((mu) eff) and the absorption coefficient ((mu) a), and (2) the well-known integrating sphere technique which measured total transmittance (Tt) nd total diffuse reflectance (Rd). The skin pieces were wrapped in water-tight packets and heated for 20 minutes in a calibrated water bath (temperature range: 20 degree(s) - 90 degree(s)C) and the same skin samples were used for both measurement methods. The experimental data were analyzed to specify the absorption and the scattering properties. The results, which were in general agreement for both methods, indicated that denaturation of the rat skin caused a decrease in scattering due to melting of the collagen fibers. The decrease began at 55 degree(s)C and plateaued at 65 degree(s) - 70 degree(s)C and was essentially unchanged at higher temperatures. Absorption was not significantly affected by denaturation except for a transient rise at 50 degree(s) - 60 degree(s)C.

  17. An integrated assessment of seawater intrusion in a small tropical island using geophysical, geochemical, and geostatistical techniques.

    PubMed

    Kura, Nura Umar; Ramli, Mohammad Firuz; Ibrahim, Shaharin; Sulaiman, Wan Nur Azmin; Aris, Ahmad Zaharin

    2014-01-01

    In this study, geophysics, geochemistry, and geostatistical techniques were integrated to assess seawater intrusion in Kapas Island due to its geological complexity and multiple contamination sources. Five resistivity profiles were measured using an electric resistivity technique. The results reveal very low resistivity <1 Ωm, suggesting either marine clay deposit or seawater intrusion or both along the majority of the resistivity images. As a result, geochemistry was further employed to verify the resistivity evidence. The Chadha and Stiff diagrams classify the island groundwater into Ca-HCO3, Ca-Na-HCO3, Na-HCO3, and Na-Cl water types, with Ca-HCO3 as the dominant. The Mg(2+)/Mg(2+)+Ca(2+), HCO3 (-)/anion, Cl(-)/HCO3 (-), Na(+)/Cl(-), and SO4 (2-)/Cl(-) ratios show that some sampling sites are affected by seawater intrusion; these sampling sites fall within the same areas that show low-resistivity values. The resulting ratios and resistivity values were then used in the geographical information system (GIS) environment to create the geostatistical map of individual indicators. These maps were then overlaid to create the final map showing seawater-affected areas. The final map successfully delineates the area that is actually undergoing seawater intrusion. The proposed technique is not area specific, and hence, it can work in any place with similar completed characteristics or under the influence of multiple contaminants so as to distinguish the area that is truly affected by any targeted pollutants from the rest. This information would provide managers and policy makers with the knowledge of the current situation and will serve as a guide and standard in water research for sustainable management plan. PMID:24532282

  18. An integrated assessment of seawater intrusion in a small tropical island using geophysical, geochemical, and geostatistical techniques.

    PubMed

    Kura, Nura Umar; Ramli, Mohammad Firuz; Ibrahim, Shaharin; Sulaiman, Wan Nur Azmin; Aris, Ahmad Zaharin

    2014-01-01

    In this study, geophysics, geochemistry, and geostatistical techniques were integrated to assess seawater intrusion in Kapas Island due to its geological complexity and multiple contamination sources. Five resistivity profiles were measured using an electric resistivity technique. The results reveal very low resistivity <1 Ωm, suggesting either marine clay deposit or seawater intrusion or both along the majority of the resistivity images. As a result, geochemistry was further employed to verify the resistivity evidence. The Chadha and Stiff diagrams classify the island groundwater into Ca-HCO3, Ca-Na-HCO3, Na-HCO3, and Na-Cl water types, with Ca-HCO3 as the dominant. The Mg(2+)/Mg(2+)+Ca(2+), HCO3 (-)/anion, Cl(-)/HCO3 (-), Na(+)/Cl(-), and SO4 (2-)/Cl(-) ratios show that some sampling sites are affected by seawater intrusion; these sampling sites fall within the same areas that show low-resistivity values. The resulting ratios and resistivity values were then used in the geographical information system (GIS) environment to create the geostatistical map of individual indicators. These maps were then overlaid to create the final map showing seawater-affected areas. The final map successfully delineates the area that is actually undergoing seawater intrusion. The proposed technique is not area specific, and hence, it can work in any place with similar completed characteristics or under the influence of multiple contaminants so as to distinguish the area that is truly affected by any targeted pollutants from the rest. This information would provide managers and policy makers with the knowledge of the current situation and will serve as a guide and standard in water research for sustainable management plan.

  19. Integrating pan-sharpening and classifier ensemble techniques to map an invasive plant (Spartina alterniflora) in an estuarine wetland using Landsat 8 imagery

    NASA Astrophysics Data System (ADS)

    Ai, Jinquan; Gao, Wei; Gao, Zhiqiang; Shi, Runhe; Zhang, Chao; Liu, Chaoshun

    2016-04-01

    Accurate mapping of invasive species in a cost-effective way is the first step toward understanding and predicting the impact of their invasions. However, it is challenging in coastal wetlands due to confounding effects of biodiversity and tidal effects on spectral reflectance. The aim of this work is to describe a method to improve the accuracy of mapping an invasive plant (Spartina alterniflora), which is based on integration of pan-sharpening and classifier ensemble techniques. A framework was designed to achieve this goal. Five candidate image fusion algorithms, including principal component analysis fusion algorithm, modified intensity-hue-saturation fusion algorithm, wavelet-transform fusion algorithm, Ehlers fusion algorithm, and Gram-Schmidt fusion algorithm, were applied to pan-sharpening Landsat 8 operational land imager (OLI) imagery. We assessed the five fusion algorithms with respect to spectral and spatial fidelity using visual inspection and quantitative quality indicators. The optimal fused image was selected for subsequent analysis. Then, three classifiers, namely, maximum likelihood, artificial neural network, and support vector machine, were employed to preclassify the fused and raw OLI 30-m band images. Final object-based S. alterniflora maps were generated through classifier ensemble analysis of outcomes from the three classifiers. The results showed that the introduced method obtained high classification accuracy, with an overall accuracy of 90.96% and balanced misclassification errors between S. alterniflora and its coexistent species. We recommend future research to adopt the proposed method for monitoring long-term or multiseasonal changes in land coverage of invasive wetland plants.

  20. The OpenMI - its Transformation From a Research Output to a Global Standard for the Integrated Modelling Community

    NASA Astrophysics Data System (ADS)

    Moore, R.

    2008-12-01

    The pressure to take a more integrated approach both to science and to management increases by the day. At almost any scale from local to global, it is no longer possible to consider issues in isolation; to do so runs a high risk of creating more problems than are solved. The consequence of this situation is that there is strong encouragement in the scientific world not just to understand and to be able to predict the response of individual processes but also to predict how those processes will interact. The manager is similarly encouraged to think in the widest terms about the likely impact of any policy before it is implemented. A new reservoir may solve a water supply problem but will it adversely affect the fishing and hence the tourist trade? How will climate change impact biodiversity? Will the drugs for treating a flu pandemic adversely affect river water quality? One approach to predicting such impacts would be to create new models simulating more and more processes. This, however, is neither feasible nor useful and makes poor use of the huge investment in existing models. A better approach, with many additional benefits, would be to find a way of linking existing models and modelling components such as databases or visualisation systems. Against this background, the European Commission, as part of its research programme to facilitate the introduction of integrated water management, commissioned a community project to find a generic solution to the linking of simulation models at run time. The outcome of this work was the Open Modelling Interface (OpenMI) standard and the creation of the OpenMI Association, an open, non-proprietary, not-for-profit, international organisation for its support. The work has received widespread recognition and encouragement from across the world, especially in the USA. A second phase is now building a community to continue the OpenMI's development and promote its use. The community's vision, mission and implementation strategy