Continuous integration for concurrent MOOSE framework and application development on GitHub

DOE PAGES

Slaughter, Andrew E.; Peterson, John W.; Gaston, Derek R.; ...

2015-11-20

For the past several years, Idaho National Laboratory’s MOOSE framework team has employed modern software engineering techniques (continuous integration, joint application/framework source code repos- itories, automated regression testing, etc.) in developing closed-source multiphysics simulation software (Gaston et al., Journal of Open Research Software vol. 2, article e10, 2014). In March 2014, the MOOSE framework was released under an open source license on GitHub, significantly expanding and diversifying the pool of current active and potential future contributors on the project. Despite this recent growth, the same philosophy of concurrent framework and application development continues to guide the project’s development roadmap. Severalmore » specific practices, including techniques for managing multiple repositories, conducting automated regression testing, and implementing a cascading build process are discussed in this short paper. Furthermore, special attention is given to describing the manner in which these practices naturally synergize with the GitHub API and GitHub-specific features such as issue tracking, Pull Requests, and project forks.« less

Continuous integration for concurrent MOOSE framework and application development on GitHub

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slaughter, Andrew E.; Peterson, John W.; Gaston, Derek R.

For the past several years, Idaho National Laboratory’s MOOSE framework team has employed modern software engineering techniques (continuous integration, joint application/framework source code repos- itories, automated regression testing, etc.) in developing closed-source multiphysics simulation software (Gaston et al., Journal of Open Research Software vol. 2, article e10, 2014). In March 2014, the MOOSE framework was released under an open source license on GitHub, significantly expanding and diversifying the pool of current active and potential future contributors on the project. Despite this recent growth, the same philosophy of concurrent framework and application development continues to guide the project’s development roadmap. Severalmore » specific practices, including techniques for managing multiple repositories, conducting automated regression testing, and implementing a cascading build process are discussed in this short paper. Furthermore, special attention is given to describing the manner in which these practices naturally synergize with the GitHub API and GitHub-specific features such as issue tracking, Pull Requests, and project forks.« less

Theory and operational rules for the discrete Hankel transform.

PubMed

Baddour, Natalie; Chouinard, Ugo

2015-04-01

Previous definitions of a discrete Hankel transform (DHT) have focused on methods to approximate the continuous Hankel integral transform. In this paper, we propose and evaluate the theory of a DHT that is shown to arise from a discretization scheme based on the theory of Fourier-Bessel expansions. The proposed transform also possesses requisite orthogonality properties which lead to invertibility of the transform. The standard set of shift, modulation, multiplication, and convolution rules are derived. In addition to the theory of the actual manipulated quantities which stand in their own right, this DHT can be used to approximate the continuous forward and inverse Hankel transform in the same manner that the discrete Fourier transform is known to be able to approximate the continuous Fourier transform.

26 CFR 1.881-1 - Manner of taxing foreign corporations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Manner of taxing foreign corporations. 1.881-1... TAX (CONTINUED) INCOME TAXES (CONTINUED) Foreign Corporations § 1.881-1 Manner of taxing foreign corporations. (a) Classes of foreign corporations. For purposes of the income tax, foreign corporations are...

26 CFR 1.881-1 - Manner of taxing foreign corporations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Manner of taxing foreign corporations. 1.881-1... TAX (CONTINUED) INCOME TAXES (CONTINUED) Foreign Corporations § 1.881-1 Manner of taxing foreign corporations. (a) Classes of foreign corporations. For purposes of the income tax, foreign corporations are...

26 CFR 1.881-1 - Manner of taxing foreign corporations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Manner of taxing foreign corporations. 1.881-1... TAX (CONTINUED) INCOME TAXES (CONTINUED) Foreign Corporations § 1.881-1 Manner of taxing foreign corporations. (a) Classes of foreign corporations. For purposes of the income tax, foreign corporations are...

26 CFR 1.881-1 - Manner of taxing foreign corporations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Manner of taxing foreign corporations. 1.881-1... TAX (CONTINUED) INCOME TAXES (CONTINUED) Foreign Corporations § 1.881-1 Manner of taxing foreign corporations. (a) Classes of foreign corporations. For purposes of the income tax, foreign corporations are...

26 CFR 1.9004-4 - Manner of exercising election.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Manner of exercising election. 1.9004-4 Section 1.9004-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES General Actuarial Valuations § 1.9004-4 Manner of exercising election. (a...

26 CFR 1.9003-4 - Manner of exercising election.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Manner of exercising election. 1.9003-4 Section 1.9003-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES General Actuarial Valuations § 1.9003-4 Manner of exercising election. (a...

26 CFR 1.9005-4 - Manner of exercising election.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Manner of exercising election. 1.9005-4 Section 1.9005-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES General Actuarial Valuations § 1.9005-4 Manner of exercising election. (a...

26 CFR 1.9002-8 - Manner of exercising elections.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Manner of exercising elections. 1.9002-8 Section 1.9002-8 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES General Actuarial Valuations § 1.9002-8 Manner of exercising elections...

The Urban melting pot: A recipe for sustainable living?

NASA Astrophysics Data System (ADS)

Terblanche, Deon

2015-04-01

Many of the milestones of human development can be traced back to people assembled in groups where economies of scale, competition and social interaction stimulated innovation. Considering that more than half the global pollution now lives in cities and towns and that most of the growth in the global pollution in the remainder of this century will continue to take place in the urban environment, the question could be asked whether humankind will continue to capitalize on the traditional benefits of city life to find solutions for growing environmental challenges? By ensuring that cities are planned and operated to make best use of the prevailing climate, resources and in a manner in which its inhabitants are safe from extreme weather and environmental events there is a good chance that cities will continue to contribute to solutions. However, if cities are allowed to developed in a haphazard manner with poorly managed infrastructure which expose citizens to the dangers of a changing climate and environmental degradation, the fight for survival will overshadow the entrepreneurial spirit. There is now a window of opportunity for weather, climate, water and environmental scientists to contribute towards a more sustainable urban future by ensuring that services based on these sciences from an integrated part of urban development and management. WMO recognizes that the rapid urbanization will require new types of services making best use of science and technology and considers this problem as one of the main priorities. Such Integrated Urban Weather, Environment and Climate Services should assist cities in facing hazards such as storm surge, flooding, heat waves, and air pollution episodes, especially in changing climates. The talk will highlight some of the opportunities that exist in this regard.

26 CFR 1.871-1 - Classification and manner of taxing alien individuals.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Classification and manner of taxing alien... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Nonresident Aliens and Foreign Corporations § 1.871-1 Classification and manner of taxing alien individuals. (a) Classes of aliens. For purposes of the income tax...

Expert systems applications for space shuttle payload integration automation

NASA Technical Reports Server (NTRS)

Morris, Keith

1988-01-01

Expert systems technologies have been and are continuing to be applied to NASA's Space Shuttle orbiter payload integration problems to provide a level of automation previously unrealizable. NASA's Space Shuttle orbiter was designed to be extremely flexible in its ability to accommodate many different types and combinations of satellites and experiments (payloads) within its payload bay. This flexibility results in differnet and unique engineering resource requirements for each of its payloads, creating recurring payload and cargo integration problems. Expert systems provide a successful solution for these recurring problems. The Orbiter Payload Bay Cabling Expert (EXCABL) was the first expert system, developed to solve the electrical services provisioning problem. A second expert system, EXMATCH, was developed to generate a list of the reusable installation drawings available for each EXCABL solution. These successes have proved the applicability of expert systems technologies to payload integration problems and consequently a third expert system is currently in work. These three expert systems, the manner in which they resolve payload problems and how they will be integrated are described.

Architecture-Centric Development in Globally Distributed Projects

NASA Astrophysics Data System (ADS)

Sauer, Joachim

In this chapter architecture-centric development is proposed as a means to strengthen the cohesion of distributed teams and to tackle challenges due to geographical and temporal distances and the clash of different cultures. A shared software architecture serves as blueprint for all activities in the development process and ties them together. Architecture-centric development thus provides a plan for task allocation, facilitates the cooperation of globally distributed developers, and enables continuous integration reaching across distributed teams. Advice is also provided for software architects who work with distributed teams in an agile manner.

Integral reinforcement learning for continuous-time input-affine nonlinear systems with simultaneous invariant explorations.

PubMed

Lee, Jae Young; Park, Jin Bae; Choi, Yoon Ho

2015-05-01

This paper focuses on a class of reinforcement learning (RL) algorithms, named integral RL (I-RL), that solve continuous-time (CT) nonlinear optimal control problems with input-affine system dynamics. First, we extend the concepts of exploration, integral temporal difference, and invariant admissibility to the target CT nonlinear system that is governed by a control policy plus a probing signal called an exploration. Then, we show input-to-state stability (ISS) and invariant admissibility of the closed-loop systems with the policies generated by integral policy iteration (I-PI) or invariantly admissible PI (IA-PI) method. Based on these, three online I-RL algorithms named explorized I-PI and integral Q -learning I, II are proposed, all of which generate the same convergent sequences as I-PI and IA-PI under the required excitation condition on the exploration. All the proposed methods are partially or completely model free, and can simultaneously explore the state space in a stable manner during the online learning processes. ISS, invariant admissibility, and convergence properties of the proposed methods are also investigated, and related with these, we show the design principles of the exploration for safe learning. Neural-network-based implementation methods for the proposed schemes are also presented in this paper. Finally, several numerical simulations are carried out to verify the effectiveness of the proposed methods.

A comparative study of integrated pest management strategies based on impulsive control.

PubMed

Páez Chávez, Joseph; Jungmann, Dirk; Siegmund, Stefan

2018-12-01

The paper presents a comprehensive numerical study of mathematical models used to describe complex biological systems in the framework of integrated pest management. Our study considers two specific ecosystems that describe the application of control mechanisms based on pesticides and natural enemies, implemented in an impulsive and periodic manner, due to which the considered models belong to the class of impulsive differential equations. The present work proposes a numerical approach to study such type of models in detail, via the application of path-following (continuation) techniques for nonsmooth dynamical systems, via the novel continuation platform COCO (Dankowicz and Schilder). In this way, a detailed study focusing on the influence of selected system parameters on the effectiveness of the pest control scheme is carried out for both ecological scenarios. Furthermore, a comparative study is presented, with special emphasis on the mechanisms upon which a pest outbreak can occur in the considered ecosystems. Our study reveals that such outbreaks are determined by the presence of a branching point found during the continuation analysis. The numerical investigation concludes with an in-depth study of the state-dependent pesticide mortality considered in one of the ecological scenarios.

Surface-from-gradients without discrete integrability enforcement: A Gaussian kernel approach.

PubMed

Ng, Heung-Sun; Wu, Tai-Pang; Tang, Chi-Keung

2010-11-01

Representative surface reconstruction algorithms taking a gradient field as input enforce the integrability constraint in a discrete manner. While enforcing integrability allows the subsequent integration to produce surface heights, existing algorithms have one or more of the following disadvantages: They can only handle dense per-pixel gradient fields, smooth out sharp features in a partially integrable field, or produce severe surface distortion in the results. In this paper, we present a method which does not enforce discrete integrability and reconstructs a 3D continuous surface from a gradient or a height field, or a combination of both, which can be dense or sparse. The key to our approach is the use of kernel basis functions, which transfer the continuous surface reconstruction problem into high-dimensional space, where a closed-form solution exists. By using the Gaussian kernel, we can derive a straightforward implementation which is able to produce results better than traditional techniques. In general, an important advantage of our kernel-based method is that the method does not suffer discretization and finite approximation, both of which lead to surface distortion, which is typical of Fourier or wavelet bases widely adopted by previous representative approaches. We perform comparisons with classical and recent methods on benchmark as well as challenging data sets to demonstrate that our method produces accurate surface reconstruction that preserves salient and sharp features. The source code and executable of the system are available for downloading.

Integrated micro-optofluidic platform for real-time detection of airborne microorganisms

NASA Astrophysics Data System (ADS)

Choi, Jeongan; Kang, Miran; Jung, Jae Hee

2015-11-01

We demonstrate an integrated micro-optofluidic platform for real-time, continuous detection and quantification of airborne microorganisms. Measurements of the fluorescence and light scattering from single particles in a microfluidic channel are used to determine the total particle number concentration and the microorganism number concentration in real-time. The system performance is examined by evaluating standard particle measurements with various sample flow rates and the ratios of fluorescent to non-fluorescent particles. To apply this method to real-time detection of airborne microorganisms, airborne Escherichia coli, Bacillus subtilis, and Staphylococcus epidermidis cells were introduced into the micro-optofluidic platform via bioaerosol generation, and a liquid-type particle collection setup was used. We demonstrate successful discrimination of SYTO82-dyed fluorescent bacterial cells from other residue particles in a continuous and real-time manner. In comparison with traditional microscopy cell counting and colony culture methods, this micro-optofluidic platform is not only more accurate in terms of the detection efficiency for airborne microorganisms but it also provides additional information on the total particle number concentration.

Integrated micro-optofluidic platform for real-time detection of airborne microorganisms

PubMed Central

Choi, Jeongan; Kang, Miran; Jung, Jae Hee

2015-01-01

We demonstrate an integrated micro-optofluidic platform for real-time, continuous detection and quantification of airborne microorganisms. Measurements of the fluorescence and light scattering from single particles in a microfluidic channel are used to determine the total particle number concentration and the microorganism number concentration in real-time. The system performance is examined by evaluating standard particle measurements with various sample flow rates and the ratios of fluorescent to non-fluorescent particles. To apply this method to real-time detection of airborne microorganisms, airborne Escherichia coli, Bacillus subtilis, and Staphylococcus epidermidis cells were introduced into the micro-optofluidic platform via bioaerosol generation, and a liquid-type particle collection setup was used. We demonstrate successful discrimination of SYTO82-dyed fluorescent bacterial cells from other residue particles in a continuous and real-time manner. In comparison with traditional microscopy cell counting and colony culture methods, this micro-optofluidic platform is not only more accurate in terms of the detection efficiency for airborne microorganisms but it also provides additional information on the total particle number concentration. PMID:26522006

40 CFR 141.204 - Tier 3 Public Notice-Form, manner, and frequency of notice.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Public Notification of Drinking Water Violations § 141.204 Tier 3 Public Notice—Form, manner, and frequency of notice. (a) Which... exemption granted under Section 1416 of the Safe Drinking Water Act; (4) Availability of unregulated...

40 CFR 141.204 - Tier 3 Public Notice-Form, manner, and frequency of notice.

Code of Federal Regulations, 2013 CFR

2013-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Public Notification of Drinking Water Violations § 141.204 Tier 3 Public Notice—Form, manner, and frequency of notice. (a) Which... exemption granted under Section 1416 of the Safe Drinking Water Act; (4) Availability of unregulated...

40 CFR 141.204 - Tier 3 Public Notice-Form, manner, and frequency of notice.

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Public Notification of Drinking Water Violations § 141.204 Tier 3 Public Notice—Form, manner, and frequency of notice. (a) Which... exemption granted under Section 1416 of the Safe Drinking Water Act; (4) Availability of unregulated...

40 CFR 141.204 - Tier 3 Public Notice-Form, manner, and frequency of notice.

Code of Federal Regulations, 2014 CFR

2014-07-01

... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Public Notification of Drinking Water Violations § 141.204 Tier 3 Public Notice—Form, manner, and frequency of notice. (a) Which... exemption granted under Section 1416 of the Safe Drinking Water Act; (4) Availability of unregulated...

40 CFR 141.204 - Tier 3 Public Notice-Form, manner, and frequency of notice.

Code of Federal Regulations, 2010 CFR

2010-07-01

... exemption granted under Section 1416 of the Safe Drinking Water Act; (4) Availability of unregulated... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Public Notification of Drinking Water Violations § 141.204 Tier 3 Public Notice—Form, manner, and frequency of notice. (a) Which...

40 CFR 266.21 - Standards applicable to generators and transporters of materials used in a manner that...

Code of Federal Regulations, 2010 CFR

2010-07-01

... transporters of materials used in a manner that constitutes disposal. 266.21 Section 266.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Recyclable...

Key steps for integrating a basic science throughout a medical school curriculum using an e-learning approach.

PubMed

Dubois, Eline Agnès; Franson, Kari Lanette

2009-09-01

Basic sciences can be integrated into the medical school curriculum via e-learning. The process of integrating a basic science in this manner resembles a curricular change. The change usually begins with an idea for using e-learning to teach a basic science and establishing the need for the innovation. In the planning phase, learning outcomes are formulated and a prototype of the program is developed based on the desired requirements. A realistic concept is formed after considering the limitations of the current institute. Next, a project team is assembled to develop the program and plan its integration. Incorporation of the e-learning program is facilitated by a well-developed and communicated integration plan. Various course coordinators are contacted to determine content of the e-learning program as well as establish assessment. Linking the e-learning program to existing course activities and thereby applying the basic science into the clinical context enhances the degree of integration. The success of the integration is demonstrated by a positive assessment of the program including favourable cost-benefit analysis and improved student performance. Lastly, when the program becomes institutionalised, continuously updating content and technology (when appropriate), and evaluating the integration contribute to the prolonged survival of the e-learning program.

[No exchange of information without technology : modern infrastructure in radiology].

PubMed

Hupperts, H; Hermann, K-G A

2014-01-01

Modern radiology cannot accomplish the daily numbers of examinations without supportive technology. Even though technology seems to be becoming increasingly more indispensable, business continuity should be ensured at any time and if necessary even with a limited technical infrastructure by business continuity management. An efficient information security management system forms the basis. The early radiology information systems were islands of information processing. A modern radiology department must be able to be modularly integrated into an informational network of a bigger organization. The secondary use of stored data for clinical decision-making support poses new challenges for the integrity of the data or systems because medical knowledge is displayed and provided in a context of treatment. In terms of imaging the creation and distribution radiology services work in a fully digital manner which is often different for radiology reports. Legally secure electronic diagnostic reports require a complex technical infrastructure; therefore, diagnostic findings still need to be filed as a paper document. The internal exchange and an improved dose management can be simplified by systems which continuously and automatically record the doses and thus provide the possibility of permanent analysis and reporting. Communication between patient and radiologist will gain ongoing importance. Intelligent use of technology will convey this to the radiologist and it will facilitate the understanding of the information by the patient.

[Sustainable process improvement with application of 'lean philosophy'].

PubMed

Rouppe van der Voort, Marc B V; van Merode, G G Frits; Veraart, Henricus G N

2013-01-01

Process improvement is increasingly being implemented, particularly with the aid of 'lean philosophy'. This management philosophy aims to improve quality by reducing 'wastage'. Local improvements can produce negative effects elsewhere due to interdependence of processes. An 'integrated system approach' is required to prevent this. Some hospitals claim that this has been successful. Research into process improvement with the application of lean philosophy has reported many positive effects, defined as improved safety, quality and efficiency. Due to methodological shortcomings and lack of rigorous evaluations it is, however, not yet possible to determine the impact of this approach. It is, however, obvious that the investigated applications are fragmentary, with a dominant focus on the instrumental aspect of the philosophy and a lack of integration in a total system, and with insufficient attention to human aspects. Process improvement is required to achieve better and more goal-oriented healthcare. To achieve this, hospitals must develop integrated system approaches that combine methods for process design with continuous improvement of processes and with personnel management. It is crucial that doctors take the initiative to guide and improve processes in an integral manner.

26 CFR 1.472-3 - Time and manner of making election.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 1.472-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Inventories § 1.472-3 Time and manner of making election. (a) The LIFO inventory method may be adopted and used only if the taxpayer files with his income tax return for the...

40 CFR 141.202 - Tier 1 Public Notice-Form, manner, and frequency of notice.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Detection of E. coli, enterococci, or coliphage in source water samples as specified in § 141.402(a) and... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Public Notification of Drinking Water Violations § 141.202 Tier 1 Public Notice—Form, manner, and frequency of notice. (a) Which...

40 CFR 141.202 - Tier 1 Public Notice-Form, manner, and frequency of notice.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., or coliphage in source water samples as specified in § 141.402(a) and § 141.402(b); (9) Other... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Public Notification of Drinking Water Violations § 141.202 Tier 1 Public Notice—Form, manner, and frequency of notice. (a) Which...

40 CFR 141.202 - Tier 1 Public Notice-Form, manner, and frequency of notice.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., or coliphage in source water samples as specified in § 141.402(a) and § 141.402(b); (9) Other... (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Public Notification of Drinking Water Violations § 141.202 Tier 1 Public Notice—Form, manner, and frequency of notice. (a) Which...

40 CFR 266.22 - Standards applicable to storers of materials that are to be used in a manner that constitutes...

Code of Federal Regulations, 2010 CFR

2010-07-01

... materials that are to be used in a manner that constitutes disposal who are not the ultimate users. 266.22 Section 266.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE...

Customizing cell signaling using engineered genetic logic circuits.

PubMed

Wang, Baojun; Buck, Martin

2012-08-01

Cells live in an ever-changing environment and continuously sense, process and react to environmental signals using their inherent signaling and gene regulatory networks. Recently, there have been great advances on rewiring the native cell signaling and gene networks to program cells to sense multiple noncognate signals and integrate them in a logical manner before initiating a desired response. Here, we summarize the current state-of-the-art of engineering synthetic genetic logic circuits to customize cellular signaling behaviors, and discuss their promising applications in biocomputing, environmental, biotechnological and biomedical areas as well as the remaining challenges in this growing field. Copyright © 2012 Elsevier Ltd. All rights reserved.

Adult-born neurons modify excitatory synaptic transmission to existing neurons

PubMed Central

Adlaf, Elena W; Vaden, Ryan J; Niver, Anastasia J; Manuel, Allison F; Onyilo, Vincent C; Araujo, Matheus T; Dieni, Cristina V; Vo, Hai T; King, Gwendalyn D; Wadiche, Jacques I; Overstreet-Wadiche, Linda

2017-01-01

Adult-born neurons are continually produced in the dentate gyrus but it is unclear whether synaptic integration of new neurons affects the pre-existing circuit. Here we investigated how manipulating neurogenesis in adult mice alters excitatory synaptic transmission to mature dentate neurons. Enhancing neurogenesis by conditional deletion of the pro-apoptotic gene Bax in stem cells reduced excitatory postsynaptic currents (EPSCs) and spine density in mature neurons, whereas genetic ablation of neurogenesis increased EPSCs in mature neurons. Unexpectedly, we found that Bax deletion in developing and mature dentate neurons increased EPSCs and prevented neurogenesis-induced synaptic suppression. Together these results show that neurogenesis modifies synaptic transmission to mature neurons in a manner consistent with a redistribution of pre-existing synapses to newly integrating neurons and that a non-apoptotic function of the Bax signaling pathway contributes to ongoing synaptic refinement within the dentate circuit. DOI: http://dx.doi.org/10.7554/eLife.19886.001 PMID:28135190

26 CFR 1.382-10 - Special rules for determining time and manner of acquisition of an interest in a loss corporation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Special rules for determining time and manner of acquisition of an interest in a loss corporation. 1.382-10 Section 1.382-10 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency...

29 CFR 1905.21 - Manner of service.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-STEIGER OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970 Hearings § 1905.21 Manner of service. Service of any... 29 Labor 5 2010-07-01 2010-07-01 false Manner of service. 1905.21 Section 1905.21 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...

14 CFR 137.37 - Manner of dispensing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Manner of dispensing. 137.37 Section 137.37 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... aircraft, any material or substance in a manner that creates a hazard to persons or property on the surface...

14 CFR 137.37 - Manner of dispensing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Manner of dispensing. 137.37 Section 137.37 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... aircraft, any material or substance in a manner that creates a hazard to persons or property on the surface...

14 CFR 137.37 - Manner of dispensing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Manner of dispensing. 137.37 Section 137.37 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... aircraft, any material or substance in a manner that creates a hazard to persons or property on the surface...

14 CFR 137.37 - Manner of dispensing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Manner of dispensing. 137.37 Section 137.37 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... aircraft, any material or substance in a manner that creates a hazard to persons or property on the surface...

Toward population management in an integrated care model.

PubMed

Maddux, Franklin W; McMurray, Stephen; Nissenson, Allen R

2013-04-01

Under the Patient Protection and Affordable Care Act of 2010, accountable care organizations (ACOs) will be the primary mechanism for achieving the dual goals of high-quality patient care at managed per capita costs. To achieve these goals in the newly emerging health care environment, the nephrology community must plan for and direct integrated delivery and coordination of renal care, focusing on population management. Even though the ESRD patient population is a complex group with comorbid conditions that may confound integration of care, the nephrology community has unique experience providing integrated care through ACO-like programs. Specifically, the recent ESRD Management Demonstration Project sponsored by the Centers for Medicare & Medicaid Services and the current ESRD Prospective Payment System with it Quality Incentive Program have demonstrated that integrated delivery of renal care can be accomplished in a manner that provides improved clinical outcomes with some financial margin of savings. Moving forward, integrated renal care will probably be linked to provider performance and quality outcomes measures, and clinical integration initiatives will share several common elements, namely performance-based payment models, coordination of communication via health care information technology, and development of best practices for care coordination and resource utilization. Integration initiatives must be designed to be measured and evaluated, and, consistent with principles of continuous quality improvement, each initiative will provide for iterative improvements of the initiative.

Toward population management in an integrated care model.

PubMed

Maddux, Franklin W; McMurray, Stephen; Nissenson, Allen R

2013-01-01

Under the Patient Protection and Affordable Care Act of 2010, accountable care organizations (ACOs) will be the primary mechanism for achieving the dual goals of high-quality patient care at managed per capita costs. To achieve these goals in the newly emerging health care environment, the nephrology community must plan for and direct integrated delivery and coordination of renal care, focusing on population management. Even though the ESRD patient population is a complex group with comorbid conditions that may confound integration of care, the nephrology community has unique experience providing integrated care through ACO-like programs. Specifically, the recent ESRD Management Demonstration Project sponsored by the Centers for Medicare & Medicaid Services and the current ESRD Prospective Payment System with it Quality Incentive Program have demonstrated that integrated delivery of renal care can be accomplished in a manner that provides improved clinical outcomes with some financial margin of savings. Moving forward, integrated renal care will probably be linked to provider performance and quality outcomes measures, and clinical integration initiatives will share several common elements, namely performance-based payment models, coordination of communication via health care information technology, and development of best practices for care coordination and resource utilization. Integration initiatives must be designed to be measured and evaluated, and, consistent with principles of continuous quality improvement, each initiative will provide for iterative improvements of the initiative. © 2013 S. Karger AG, Basel.

Modelling crystal plasticity by 3D dislocation dynamics and the finite element method: The Discrete-Continuous Model revisited

NASA Astrophysics Data System (ADS)

Vattré, A.; Devincre, B.; Feyel, F.; Gatti, R.; Groh, S.; Jamond, O.; Roos, A.

2014-02-01

A unified model coupling 3D dislocation dynamics (DD) simulations with the finite element (FE) method is revisited. The so-called Discrete-Continuous Model (DCM) aims to predict plastic flow at the (sub-)micron length scale of materials with complex boundary conditions. The evolution of the dislocation microstructure and the short-range dislocation-dislocation interactions are calculated with a DD code. The long-range mechanical fields due to the dislocations are calculated by a FE code, taking into account the boundary conditions. The coupling procedure is based on eigenstrain theory, and the precise manner in which the plastic slip, i.e. the dislocation glide as calculated by the DD code, is transferred to the integration points of the FE mesh is described in full detail. Several test cases are presented, and the DCM is applied to plastic flow in a single-crystal Nickel-based superalloy.

Development of a portable analyzer with polymer lab-on-a-chip (LOC) for continuous sampling and monitoring of Pb(II).

PubMed

Jang, A; Zou, Z; MacKnight, E; Wu, P M; Kim, I S; Ahn, C H; Bishop, P L

2009-01-01

A new portable analyzer with polymer lab-on-a-chip (LOC) has been designed, fabricated and fully characterized for continuous sampling and monitoring of lead (Pb(II)) in this work. As the working electrodes of the sensor, bismuth (Bi (III)) which allowed the advantage of being more environmentally friendly than traditional mercury drop electrodes was used, while maintaining similar sensitivity and other desirable characteristics. The size of a portable analyzer was 30 cmx23 cmx7 cm, and the weight was around 3 kg. The small size gives the advantage of being portable for field use while not sacrificing portability for accuracy of measurement. Furthermore, the autonomous system developed in coordination with the development of new polymer LOC integrated with electrochemical sensors can provide an innovative way to monitor surface waters in an efficient, cost-effective and sustainable manner.

26 CFR 1.881-1 - Manner of taxing foreign corporations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Manner of taxing foreign corporations. 1.881-1... TAX (CONTINUED) INCOME TAXES Foreign Corporations § 1.881-1 Manner of taxing foreign corporations. (a) Classes of foreign corporations. For purposes of the income tax, foreign corporations are divided into two...

26 CFR 1.669(b)-2 - Manner of exercising election.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Manner of exercising election. 1.669(b)-2 Section 1.669(b)-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... Years Beginning Before January 1, 1969 § 1.669(b)-2 Manner of exercising election. (a) By whom election...

49 CFR 375.601 - Must I transport the shipment in a timely manner?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 5 2011-10-01 2011-10-01 false Must I transport the shipment in a timely manner? 375.601 Section 375.601 Transportation Other Regulations Relating to Transportation (Continued... Transportation of Shipments § 375.601 Must I transport the shipment in a timely manner? Yes. Transportation in a...

49 CFR 375.601 - Must I transport the shipment in a timely manner?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Must I transport the shipment in a timely manner? 375.601 Section 375.601 Transportation Other Regulations Relating to Transportation (Continued... Transportation of Shipments § 375.601 Must I transport the shipment in a timely manner? Yes. Transportation in a...

29 CFR 4044.10 - Manner of allocation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 9 2014-07-01 2014-07-01 false Manner of allocation. 4044.10 Section 4044.10 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS ALLOCATION OF ASSETS IN SINGLE-EMPLOYER PLANS Allocation of Assets Allocation of Assets to Benefit Categories § 4044.10 Manner of allocation. (a) General. The...

29 CFR 4044.10 - Manner of allocation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 9 2012-07-01 2012-07-01 false Manner of allocation. 4044.10 Section 4044.10 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS ALLOCATION OF ASSETS IN SINGLE-EMPLOYER PLANS Allocation of Assets Allocation of Assets to Benefit Categories § 4044.10 Manner of allocation. (a) General. The...

29 CFR 4044.10 - Manner of allocation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 9 2011-07-01 2011-07-01 false Manner of allocation. 4044.10 Section 4044.10 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS ALLOCATION OF ASSETS IN SINGLE-EMPLOYER PLANS Allocation of Assets Allocation of Assets to Benefit Categories § 4044.10 Manner of allocation. Link to an...

29 CFR 4044.10 - Manner of allocation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 9 2013-07-01 2013-07-01 false Manner of allocation. 4044.10 Section 4044.10 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS ALLOCATION OF ASSETS IN SINGLE-EMPLOYER PLANS Allocation of Assets Allocation of Assets to Benefit Categories § 4044.10 Manner of allocation. (a) General. The...

Microgel mechanics in biomaterial design.

PubMed

Saxena, Shalini; Hansen, Caroline E; Lyon, L Andrew

2014-08-19

The field of polymeric biomaterials has received much attention in recent years due to its potential for enhancing the biocompatibility of systems and devices applied to drug delivery and tissue engineering. Such applications continually push the definition of biocompatibility from relatively straightforward issues such as cytotoxicity to significantly more complex processes such as reducing foreign body responses or even promoting/recapitulating natural body functions. Hydrogels and their colloidal analogues, microgels, have been and continue to be heavily investigated as viable materials for biological applications because they offer numerous, facile avenues in tailoring chemical and physical properties to approach biologically harmonious integration. Mechanical properties in particular are recently coming into focus as an important manner in which biological responses can be altered. In this Account, we trace how mechanical properties of microgels have moved into the spotlight of research efforts with the realization of their potential impact in biologically integrative systems. We discuss early experiments in our lab and in others focused on synthetic modulation of particle structure at a rudimentary level for fundamental drug delivery studies. These experiments elucidated that microgel mechanics are a consequence of polymer network distribution, which can be controlled by chemical composition or particle architecture. The degree of deformability designed into the microgel allows for a defined response to an imposed external force. We have studied deformation in packed colloidal phases and in translocation events through confined pores; in all circumstances, microgels exhibit impressive deformability in response to their environmental constraints. Microgels further translate their mechanical properties when assembled in films to the properties of the bulk material. In particular, microgel films have been a large focus in our lab as building blocks for self-healing materials. We have shown that their ability to heal after damage arises from polymer mobility during hydration. Furthermore, we have shown film mobility dictates cell adhesion and spreading in a manner that is fundamentally different from previous work on mechanotransduction. In total, we hope that this Account presents a broad introduction to microgel research that intersects polymer chemistry, physics, and regenerative medicine. We expect that research intersection will continue to expand as we fill the knowledge gaps associated with soft materials in biological milieu.

A path integral methodology for obtaining thermodynamic properties of nonadiabatic systems using Gaussian mixture distributions

NASA Astrophysics Data System (ADS)

Raymond, Neil; Iouchtchenko, Dmitri; Roy, Pierre-Nicholas; Nooijen, Marcel

2018-05-01

We introduce a new path integral Monte Carlo method for investigating nonadiabatic systems in thermal equilibrium and demonstrate an approach to reducing stochastic error. We derive a general path integral expression for the partition function in a product basis of continuous nuclear and discrete electronic degrees of freedom without the use of any mapping schemes. We separate our Hamiltonian into a harmonic portion and a coupling portion; the partition function can then be calculated as the product of a Monte Carlo estimator (of the coupling contribution to the partition function) and a normalization factor (that is evaluated analytically). A Gaussian mixture model is used to evaluate the Monte Carlo estimator in a computationally efficient manner. Using two model systems, we demonstrate our approach to reduce the stochastic error associated with the Monte Carlo estimator. We show that the selection of the harmonic oscillators comprising the sampling distribution directly affects the efficiency of the method. Our results demonstrate that our path integral Monte Carlo method's deviation from exact Trotter calculations is dominated by the choice of the sampling distribution. By improving the sampling distribution, we can drastically reduce the stochastic error leading to lower computational cost.

Refining the aggregate exposure pathway.

PubMed

Tan, Yu-Mei; Leonard, Jeremy A; Edwards, Stephen; Teeguarden, Justin; Egeghy, Peter

2018-03-01

Advancements in measurement technologies and modeling capabilities continue to result in an abundance of exposure information, adding to that currently in existence. However, fragmentation within the exposure science community acts as an obstacle for realizing the vision set forth in the National Research Council's report on Exposure Science in the 21 st century to consider exposures from source to dose, on multiple levels of integration, and to multiple stressors. The concept of an Aggregate Exposure Pathway (AEP) was proposed as a framework for organizing and integrating diverse exposure information that exists across numerous repositories and among multiple scientific fields. A workshop held in May 2016 followed introduction of the AEP concept, allowing members of the exposure science community to provide extensive evaluation and feedback regarding the framework's structure, key components, and applications. The current work briefly introduces topics discussed at the workshop and attempts to address key challenges involved in refining this framework. The resulting evolution in the AEP framework's features allows for facilitating acquisition, integration, organization, and transparent application and communication of exposure knowledge in a manner that is independent of its ultimate use, thereby enabling reuse of such information in many applications.

Label‐Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes

PubMed Central

Kilic, Tugba; Zhang, Yu Shrike; Avci, Huseyin; Hu, Ning; Kim, Duckjin; Branco, Cristina; Aleman, Julio; Massa, Solange; Silvestri, Antonia; Kang, Jian; Desalvo, Anna; Hussaini, Mohammed Abdullah; Chae, Su‐Kyoung; Polini, Alessandro; Bhise, Nupura; Hussain, Mohammad Asif; Lee, HeaYeon

2017-01-01

Development of an efficient sensing platform capable of continual monitoring of biomarkers is needed to assess the functionality of the in vitro organoids and to evaluate their biological responses toward pharmaceutical compounds or chemical species over extended periods of time. Here, a novel label‐free microfluidic electrochemical (EC) biosensor with a unique built‐in on‐chip regeneration capability for continual measurement of cell‐secreted soluble biomarkers from an organoid culture in a fully automated manner without attenuating the sensor sensitivity is reported. The microfluidic EC biosensors are integrated with a human liver‐on‐a‐chip platform for continual monitoring of the metabolic activity of the organoids by measuring the levels of secreted biomarkers for up to 7 d, where the metabolic activity of the organoids is altered by a systemically applied drug. The variations in the biomarker levels are successfully measured by the microfluidic regenerative EC biosensors and agree well with cellular viability and enzyme‐linked immunosorbent assay analyses, validating the accuracy of the unique sensing platform. It is believed that this versatile and robust microfluidic EC biosensor that is capable of automated and continual detection of soluble biomarkers will find widespread use for long‐term monitoring of human organoids during drug toxicity studies or efficacy assessments of in vitro platforms. PMID:28546915

Unified framework for information integration based on information geometry

PubMed Central

Oizumi, Masafumi; Amari, Shun-ichi

2016-01-01

Assessment of causal influences is a ubiquitous and important subject across diverse research fields. Drawn from consciousness studies, integrated information is a measure that defines integration as the degree of causal influences among elements. Whereas pairwise causal influences between elements can be quantified with existing methods, quantifying multiple influences among many elements poses two major mathematical difficulties. First, overestimation occurs due to interdependence among influences if each influence is separately quantified in a part-based manner and then simply summed over. Second, it is difficult to isolate causal influences while avoiding noncausal confounding influences. To resolve these difficulties, we propose a theoretical framework based on information geometry for the quantification of multiple causal influences with a holistic approach. We derive a measure of integrated information, which is geometrically interpreted as the divergence between the actual probability distribution of a system and an approximated probability distribution where causal influences among elements are statistically disconnected. This framework provides intuitive geometric interpretations harmonizing various information theoretic measures in a unified manner, including mutual information, transfer entropy, stochastic interaction, and integrated information, each of which is characterized by how causal influences are disconnected. In addition to the mathematical assessment of consciousness, our framework should help to analyze causal relationships in complex systems in a complete and hierarchical manner. PMID:27930289

Kennedy Space Center's NASA/Contractor Team-Centered Total Quality Management Seminar: Results, methods, and lessons learned

NASA Technical Reports Server (NTRS)

Kinlaw, Dennis C.; Eads, Jeannette

1992-01-01

It is apparent to everyone associated with the Nation's aeronautics and space programs that the challenge of continuous improvement can be reasonably addressed only if NASA and its contractors act together in a fully integrated and cooperative manner that transcends the traditional boundaries of proprietary interest. It is, however, one thing to assent to the need for such integration and cooperation; it is quite another thing to undertake the hard tasks of turning such a need into action. Whatever else total quality management is, it is fundamentally a team-centered and team-driven process of continuous improvement. The introduction of total quality management at KSC, therefore, has given the Center a special opportunity to translate the need for closer integration and cooperation among all its organizations into specific initiatives. One such initiative that NASA and its contractors have undertaken at KSC is a NASA/Contractor team-centered Total Quality Management Seminar. It is this seminar which is the subject of this paper. The specific purposes of this paper are to describe the following: Background, development, and evolution of Kennedy Space Center's Total Quality Management Seminar; Special characteristics of the seminar; Content of the seminar; Meaning and utility of a team-centered design for TQM training; Results of the seminar; Use that one KSC contractor, EG&G Florida, Inc. has made of the seminar in its Total Quality Management initiative; and Lessons learned.

49 CFR 1106.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TRANSPORTATION RULES OF PRACTICE PROCEDURES FOR SURFACE TRANSPORTATION BOARD CONSIDERATION OF SAFETY INTEGRATION... the agency within the Department of Transportation responsible for railroad safety. Safety Integration... involved in a manner that would maintain safety at every step of the integration process, in the event the...

Maximum-entropy probability distributions under Lp-norm constraints

NASA Technical Reports Server (NTRS)

Dolinar, S.

1991-01-01

Continuous probability density functions and discrete probability mass functions are tabulated which maximize the differential entropy or absolute entropy, respectively, among all probability distributions with a given L sub p norm (i.e., a given pth absolute moment when p is a finite integer) and unconstrained or constrained value set. Expressions for the maximum entropy are evaluated as functions of the L sub p norm. The most interesting results are obtained and plotted for unconstrained (real valued) continuous random variables and for integer valued discrete random variables. The maximum entropy expressions are obtained in closed form for unconstrained continuous random variables, and in this case there is a simple straight line relationship between the maximum differential entropy and the logarithm of the L sub p norm. Corresponding expressions for arbitrary discrete and constrained continuous random variables are given parametrically; closed form expressions are available only for special cases. However, simpler alternative bounds on the maximum entropy of integer valued discrete random variables are obtained by applying the differential entropy results to continuous random variables which approximate the integer valued random variables in a natural manner. All the results are presented in an integrated framework that includes continuous and discrete random variables, constraints on the permissible value set, and all possible values of p. Understanding such as this is useful in evaluating the performance of data compression schemes.

The magnetic field at the core-mantle boundary

NASA Technical Reports Server (NTRS)

Bloxham, J.; Gubbins, D.

1985-01-01

Models of the geomagnetic field are, in general, produced from a least-squares fit of the coefficients in a truncated spherical harmonic expansion to the available data. Downward continuation of such models to the core-mantle boundary (CMB) is an unstable process: the results are found to be critically dependent on the choice of truncation level. Modern techniques allow this fundamental difficulty to be circumvented. The method of stochastic inversion is applied to modeling the geomagnetic field. Prior information is introduced by requiring that the spectrum of spherical harmonic coefficients to fall-off in a particular manner which is consistent with the Ohmic heating in the core having a finite lower bound. This results in models with finite errors in the radial field at the CMB. Curves of zero radial field can then be determined and integrals of the radial field over patches on the CMB bounded by these null-flux curves calculated. With the assumption of negligible magnetic diffusion in the core; frozen-flux hypothesis, these integrals are time-invariant.

NASA Integrated Network COOP

NASA Technical Reports Server (NTRS)

Anderson, Michael L.; Wright, Nathaniel; Tai, Wallace

2012-01-01

Natural disasters, terrorist attacks, civil unrest, and other events have the potential of disrupting mission-essential operations in any space communications network. NASA's Space Communications and Navigation office (SCaN) is in the process of studying options for integrating the three existing NASA network elements, the Deep Space Network, the Near Earth Network, and the Space Network, into a single integrated network with common services and interfaces. The need to maintain Continuity of Operations (COOP) after a disastrous event has a direct impact on the future network design and operations concepts. The SCaN Integrated Network will provide support to a variety of user missions. The missions have diverse requirements and include anything from earth based platforms to planetary missions and rovers. It is presumed that an integrated network, with common interfaces and processes, provides an inherent advantage to COOP in that multiple elements and networks can provide cross-support in a seamless manner. The results of trade studies support this assumption but also show that centralization as a means of achieving integration can result in single points of failure that must be mitigated. The cost to provide this mitigation can be substantial. In support of this effort, the team evaluated the current approaches to COOP, developed multiple potential approaches to COOP in a future integrated network, evaluated the interdependencies of the various approaches to the various network control and operations options, and did a best value assessment of the options. The paper will describe the trade space, the study methods, and results of the study.

Variability in Clinical Integration Achieved by Athletic Training Students across Different Clinical Sport Assignments

ERIC Educational Resources Information Center

Dodge, Thomas M.; Mazerolle, Stephanie M.; Bowman, Thomas G.

2015-01-01

Context: Clinical integration impacts athletic training students' (ATSs) motivation and persistence. Research has yet to elucidate the manner in which different clinical placements can influence clinical integration. Objective: To examine differences in the levels of clinical integration achieved by ATSs across various clinical sport assignments.…

Building bridges, breaking barriers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonzalez, R.G.

1996-05-01

Communication is one of the most important factors in determining the success of any enterprise. It is certain to rise to the forefront for the international refining and petrochemical industries as companies seek continuous improvement in their operations. Most industry participants have recently undergone a wave of business process re-engineering, integrating new people with new practices in more areas than ever before. Companies have broken down the old functional organizations within the plant in favor of asset teams, placed renewed emphasis on optimizing profits across the entire downstream value chain and extended their global businesses to include joint venture partners.more » The goal is to empower people to make better decisions in a more timely manner to positively impact performance.« less

Software for marine ecological environment comprehensive monitoring system based on MCGS

NASA Astrophysics Data System (ADS)

Wang, X. H.; Ma, R.; Cao, X.; Cao, L.; Chu, D. Z.; Zhang, L.; Zhang, T. P.

2017-08-01

The automatic integrated monitoring software for marine ecological environment based on MCGS configuration software is designed and developed to realize real-time automatic monitoring of many marine ecological parameters. The DTU data transmission terminal performs network communication and transmits the data to the user data center in a timely manner. The software adopts the modular design and has the advantages of stable and flexible data structure, strong portability and scalability, clear interface, simple user operation and convenient maintenance. Continuous site comparison test of 6 months showed that, the relative error of the parameters monitored by the system such as temperature, salinity, turbidity, pH, dissolved oxygen was controlled within 5% with the standard method and the relative error of the nutrient parameters was within 15%. Meanwhile, the system had few maintenance times, low failure rate, stable and efficient continuous monitoring capabilities. The field application shows that the software is stable and the data communication is reliable, and it has a good application prospect in the field of marine ecological environment comprehensive monitoring.

Systems biology driven software design for the research enterprise.

PubMed

Boyle, John; Cavnor, Christopher; Killcoyne, Sarah; Shmulevich, Ilya

2008-06-25

In systems biology, and many other areas of research, there is a need for the interoperability of tools and data sources that were not originally designed to be integrated. Due to the interdisciplinary nature of systems biology, and its association with high throughput experimental platforms, there is an additional need to continually integrate new technologies. As scientists work in isolated groups, integration with other groups is rarely a consideration when building the required software tools. We illustrate an approach, through the discussion of a purpose built software architecture, which allows disparate groups to reuse tools and access data sources in a common manner. The architecture allows for: the rapid development of distributed applications; interoperability, so it can be used by a wide variety of developers and computational biologists; development using standard tools, so that it is easy to maintain and does not require a large development effort; extensibility, so that new technologies and data types can be incorporated; and non intrusive development, insofar as researchers need not to adhere to a pre-existing object model. By using a relatively simple integration strategy, based upon a common identity system and dynamically discovered interoperable services, a light-weight software architecture can become the focal point through which scientists can both get access to and analyse the plethora of experimentally derived data.

Successful strategies for integrating bedside ultrasound into undergraduate medical education.

PubMed

Palma, James K

2015-04-01

Nearly all physician specialties currently utilize bedside ultrasound, and its applications continue to expand. Bedside ultrasound is becoming a core skill for physicians; as such, it should be taught during undergraduate medical education. When ultrasound is integrated in a longitudinal manner beginning in the preclerkship phase of medical school, it not only enhances teaching the basic science topics of anatomy, physiology, and pathology but also ties those skills and knowledge to the clerkship phase and medical decision-making. Bedside ultrasound is a natural bridge from basic science to clinical science. The Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine is currently in its fourth year of implementing an integrated ultrasound curriculum in the school of medicine. In our experience, successful integration of a bedside ultrasound curriculum should: align with unique focuses of a medical schools' mission, simplify complex anatomy through multimodal teaching, correlate to teaching of the physical examination, solidify understanding of physiology and pathology, directly link to other concurrent content, narrow differential diagnoses, enhance medical decision-making, improve procedural skills, match to year-group skillsets, develop teaching and leadership abilities, and have elective experiences for advanced topics. Reprint & Copyright © 2015 Association of Military Surgeons of the U.S.

Dealing with grief related to loss by death and chronic pain: An integrated theoretical framework. Part 1

PubMed Central

Furnes, Bodil; Dysvik, Elin

2010-01-01

Objective: Based on the present authors’ research and several approaches to grief related to loss by death and nonmalignant chronic pain, the paper suggests a new integrated theoretical framework for intervention in clinical settings. Methods: An open qualitative review of the literature on grief theories was performed searching for a new integrated approach in the phenomenological tradition. We then investigated the relationship between grief, loss and chronic nonmalignant pain, looking for main themes and connections and how these could be best understood in a more holistic manner. Results: Two main themes were formulated, “relearning the world” and “adaptation”. Between these themes a continuous movement emerged involving experience such as: “despair and hope”, “lack of understanding and insight”, “meaning disruption and increased meaning”, and “bodily discomfort and reintegrated body”. These were identified as paired subthemes. Conclusions: Grief as a distinctive experience means that health care must be aimed at each individual experience and situation. Grief experience and working with grief are considered in terms of relearning the world while walking backwards and living forwards, as described in our integrated model. We consider that this theoretical framework regarding grief should offer an integrated foundation for health care workers who are working with people experiencing grief caused by death or chronic pain. PMID:20622913

INTEGRATION OF FACILITY MODELING CAPABILITIES FOR NUCLEAR NONPROLIFERATION ANALYSIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorensek, M.; Hamm, L.; Garcia, H.

2011-07-18

Developing automated methods for data collection and analysis that can facilitate nuclear nonproliferation assessment is an important research area with significant consequences for the effective global deployment of nuclear energy. Facility modeling that can integrate and interpret observations collected from monitored facilities in order to ascertain their functional details will be a critical element of these methods. Although improvements are continually sought, existing facility modeling tools can characterize all aspects of reactor operations and the majority of nuclear fuel cycle processing steps, and include algorithms for data processing and interpretation. Assessing nonproliferation status is challenging because observations can come frommore » many sources, including local and remote sensors that monitor facility operations, as well as open sources that provide specific business information about the monitored facilities, and can be of many different types. Although many current facility models are capable of analyzing large amounts of information, they have not been integrated in an analyst-friendly manner. This paper addresses some of these facility modeling capabilities and illustrates how they could be integrated and utilized for nonproliferation analysis. The inverse problem of inferring facility conditions based on collected observations is described, along with a proposed architecture and computer framework for utilizing facility modeling tools. After considering a representative sampling of key facility modeling capabilities, the proposed integration framework is illustrated with several examples.« less

Information Systems Integration and Enterprise Application Integration (EAI) Adoption: A Case from Financial Services

ERIC Educational Resources Information Center

Lam, Wing

2007-01-01

Increasingly, organizations find that they need to integrate large number of information systems in order to support enterprise-wide business initiatives such as e-business, supply chain management and customer relationship management. To date, organizations have largely tended to address information systems (IS) integration in an ad-hoc manner.…

Visual-vestibular cue integration for heading perception: applications of optimal cue integration theory.

PubMed

Fetsch, Christopher R; Deangelis, Gregory C; Angelaki, Dora E

2010-05-01

The perception of self-motion is crucial for navigation, spatial orientation and motor control. In particular, estimation of one's direction of translation, or heading, relies heavily on multisensory integration in most natural situations. Visual and nonvisual (e.g., vestibular) information can be used to judge heading, but each modality alone is often insufficient for accurate performance. It is not surprising, then, that visual and vestibular signals converge frequently in the nervous system, and that these signals interact in powerful ways at the level of behavior and perception. Early behavioral studies of visual-vestibular interactions consisted mainly of descriptive accounts of perceptual illusions and qualitative estimation tasks, often with conflicting results. In contrast, cue integration research in other modalities has benefited from the application of rigorous psychophysical techniques, guided by normative models that rest on the foundation of ideal-observer analysis and Bayesian decision theory. Here we review recent experiments that have attempted to harness these so-called optimal cue integration models for the study of self-motion perception. Some of these studies used nonhuman primate subjects, enabling direct comparisons between behavioral performance and simultaneously recorded neuronal activity. The results indicate that humans and monkeys can integrate visual and vestibular heading cues in a manner consistent with optimal integration theory, and that single neurons in the dorsal medial superior temporal area show striking correlates of the behavioral effects. This line of research and other applications of normative cue combination models should continue to shed light on mechanisms of self-motion perception and the neuronal basis of multisensory integration.

Object-Oriented Multi-Disciplinary Design, Analysis, and Optimization Tool

NASA Technical Reports Server (NTRS)

Pak, Chan-gi

2011-01-01

An Object-Oriented Optimization (O3) tool was developed that leverages existing tools and practices, and allows the easy integration and adoption of new state-of-the-art software. At the heart of the O3 tool is the Central Executive Module (CEM), which can integrate disparate software packages in a cross platform network environment so as to quickly perform optimization and design tasks in a cohesive, streamlined manner. This object-oriented framework can integrate the analysis codes for multiple disciplines instead of relying on one code to perform the analysis for all disciplines. The CEM was written in FORTRAN and the script commands for each performance index were submitted through the use of the FORTRAN Call System command. In this CEM, the user chooses an optimization methodology, defines objective and constraint functions from performance indices, and provides starting and side constraints for continuous as well as discrete design variables. The structural analysis modules such as computations of the structural weight, stress, deflection, buckling, and flutter and divergence speeds have been developed and incorporated into the O3 tool to build an object-oriented Multidisciplinary Design, Analysis, and Optimization (MDAO) tool.

Students with Sensory Integration Dysfunctions: Issues for School Counselors

ERIC Educational Resources Information Center

Katz, Idit

2006-01-01

A substantial number of school age children suffer from difficulties in integrating sensory input in an adaptive manner (termed sensory integration dysfunction--SID). These students are at high risk for emotional, social, and educational problems. This article defines SID, describes typical behaviors of children with SID, and presents guidelines…

24 CFR 207.254 - Changes in premiums; manner of publication.

Code of Federal Regulations, 2012 CFR

2012-04-01

... in premiums; manner of publication. Notice of future premium changes will be published in the Federal... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF... 30-day public comment period for the purpose of accepting comments on whether the proposed changes...

24 CFR 207.254 - Changes in premiums; manner of publication.

Code of Federal Regulations, 2013 CFR

2013-04-01

... in premiums; manner of publication. Notice of future premium changes will be published in the Federal... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF... 30-day public comment period for the purpose of accepting comments on whether the proposed changes...

Kiln for hot-pressing compacts in a continuous manner

DOEpatents

Reynolds, C.D Jr.

1983-08-08

The invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

Kiln for hot-pressing compacts in a continuous manner

DOEpatents

Reynolds, Jr., Carl D.

1985-01-01

The present invention is directed to a hot pressing furnace or kiln which is capable of preheating, hot pressing, and cooling a plurality of articles in a sequential and continuous manner. The hot pressing furnace of the present invention comprises an elongated, horizontally disposed furnace capable of holding a plurality of displaceable pusher plates each supporting a die body loaded with refractory or ceramic material to be hot pressed. Each of these plates and the die body supported thereby is sequentially pushed through the preheating zone, a temperature stabilizing and a hot pressing zone, and a cooling zone so as to provide a continuous hot-pressing operation of a plurality of articles.

Continuous and scalable fabrication of bioinspired dry adhesives via a roll-to-roll process with modulated ultraviolet-curable resin.

PubMed

Yi, Hoon; Hwang, Insol; Lee, Jeong Hyeon; Lee, Dael; Lim, Haneol; Tahk, Dongha; Sung, Minho; Bae, Won-Gyu; Choi, Se-Jin; Kwak, Moon Kyu; Jeong, Hoon Eui

2014-08-27

A simple yet scalable strategy for fabricating dry adhesives with mushroom-shaped micropillars is achieved by a combination of the roll-to-roll process and modulated UV-curable elastic poly(urethane acrylate) (e-PUA) resin. The e-PUA combines the major benefits of commercial PUA and poly(dimethylsiloxane) (PDMS). It not only can be cured within a few seconds like commercial PUA but also possesses good mechanical properties comparable to those of PDMS. A roll-type fabrication system equipped with a rollable mold and a UV exposure unit is also developed for the continuous process. By integrating the roll-to-roll process with the e-PUA, dry adhesives with spatulate tips in the form of a thin flexible film can be generated in a highly continuous and scalable manner. The fabricated dry adhesives with mushroom-shaped microstructures exhibit a strong pull-off strength of up to ∼38.7 N cm(-2) on the glass surface as well as high durability without any noticeable degradation. Furthermore, an automated substrate transportation system equipped with the dry adhesives can transport a 300 mm Si wafer over 10,000 repeating cycles with high accuracy.

31 CFR 250.5 - Manner of payment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Manner of payment. 250.5 Section 250.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE PAYMENT ON ACCOUNT OF AWARDS OF THE FOREIGN CLAIMS...

Continual exposure to cigarette smoke extracts induces tumor-like transformation of human nontumor bronchial epithelial cells in a microfluidic chip.

PubMed

Li, Encheng; Xu, Zhiyun; Liu, Fen; Wang, Huiling; Wen, Jiabin; Shao, Shujuan; Zhang, Lichuan; Wang, Lei; Liu, Chong; Lu, Jianxin; Wang, Wenxin; Gao, Zhancheng; Wang, Qi

2014-08-01

Heavy cigarette smoking-related chronic obstructive pulmonary disease is an independent risk factor for lung squamous carcinoma. However, the mechanisms underlying the malignant transformation of bronchial epithelial cells are unclear. In our study, human tumor-adjacent bronchial epithelial cells were obtained from 10 cases with smoking-related chronic obstructive pulmonary disease and lung squamous carcinoma and cultured in an established microfluidic chip for continual exposure to cigarette smoke extracts (CSE) to investigate the potential tumor-like transformation and mechanisms. The integrated microfluidic chip included upstream concentration gradient generator and downstream cell culture chambers supplied by flowing medium containing different concentrations of CSE. Our results showed that continual exposure to low doses of CSE promoted cell proliferation whereas to high doses of CSE triggered cell apoptosis. Continual exposure to CSE promoted reactive oxygen species production in human epithelial cells in a dose-dependent manner. More importantly, continual exposure to low dose of CSE promoted the epithelial-to-mesenchymal transition process and anchorage-independent growth, and increased chromosome instability in bronchial epithelial cells, accompanied by activating the GRP78, NF-κB, and PI3K pathways. The established microfluidic chip is suitable for primary culture of human tumor-adjacent bronchial epithelial cells to investigate the malignant transformation. Continual exposure to low doses of CSE promoted tumor-like transformation of human nontumor bronchial epithelial cells by inducing reactive oxygen species production and activating the relevant signaling.

Air conditioning system

DOEpatents

Lowenstein, Andrew; Miller, Jeffrey; Gruendeman, Peter; DaSilva, Michael

2005-02-01

An air conditioner comprises a plurality of plates arranged in a successively stacked configuration with portions thereof having a spaced apart arrangement, and defining between successive adjacent pairs of plates at the spaced apart portions a first and second series of discrete alternating passages wherein a first air stream is passed through the first series of passages and a second air stream is passed through the second series of passages; and said stacked configuration of plates forming integrally therewith a liquid delivery means for delivering from a source a sufficient quantity of a liquid to the inside surfaces of the first series of fluid passages in a manner which provides a continuous flow of the liquid from a first end to a second end of the plurality of plates while in contact with the first air stream.

3D Printed Multimaterial Microfluidic Valve.

PubMed

Keating, Steven J; Gariboldi, Maria Isabella; Patrick, William G; Sharma, Sunanda; Kong, David S; Oxman, Neri

2016-01-01

We present a novel 3D printed multimaterial microfluidic proportional valve. The microfluidic valve is a fundamental primitive that enables the development of programmable, automated devices for controlling fluids in a precise manner. We discuss valve characterization results, as well as exploratory design variations in channel width, membrane thickness, and membrane stiffness. Compared to previous single material 3D printed valves that are stiff, these printed valves constrain fluidic deformation spatially, through combinations of stiff and flexible materials, to enable intricate geometries in an actuated, functionally graded device. Research presented marks a shift towards 3D printing multi-property programmable fluidic devices in a single step, in which integrated multimaterial valves can be used to control complex fluidic reactions for a variety of applications, including DNA assembly and analysis, continuous sampling and sensing, and soft robotics.

An explicit solution to the exoatmospheric powered flight guidance and trajectory optimization problem for rocket propelled vehicles

NASA Technical Reports Server (NTRS)

Jaggers, R. F.

1977-01-01

A derivation of an explicit solution to the two point boundary-value problem of exoatmospheric guidance and trajectory optimization is presented. Fixed initial conditions and continuous burn, multistage thrusting are assumed. Any number of end conditions from one to six (throttling is required in the case of six) can be satisfied in an explicit and practically optimal manner. The explicit equations converge for off nominal conditions such as engine failure, abort, target switch, etc. The self starting, predictor/corrector solution involves no Newton-Rhapson iterations, numerical integration, or first guess values, and converges rapidly if physically possible. A form of this algorithm has been chosen for onboard guidance, as well as real time and preflight ground targeting and trajectory shaping for the NASA Space Shuttle Program.

Engineering Geodesy - Definition and Core Competencies

NASA Astrophysics Data System (ADS)

Kuhlmann, Heiner; Schwieger, Volker; Wieser, Andreas; Niemeier, Wolfgang

2014-11-01

This article summarises discussions concerning the definition of "engineering geodesy" within the German Geodetic Commission. It is noted that engineering geodesy by means of its tasks, methods and characteristics is an application-oriented science whose research questions often arise from observed phenomena or from unsolved practical problems. In particular it is characterised by the professional handling of geometry-related problems in a cost-effective manner that includes comprehensive quality assessment at all phases of the problem solution - from planning through measurement to data processing and interpretation. The current methodical developments are primarily characterised by the increasing integration of the measurement and analysis into challenging construction, production and monitoring processes as well as by the transition to spatially continuous methods. A modern definition of engineering geodesy is proposed at the end of this article.

An Evaluation of an Integrated Model of Speech and Language Therapy in Public Health Practice for Early Language Development

ERIC Educational Resources Information Center

Smith, Clare; Gibbard, Deborah; Higgins, Louise

2017-01-01

Speech and language therapists (SLT) frequently operate in an integrated manner, working with other professionals in the delivery of services to children. Since the end of the 1990s within the UK SLTs have developed integrated services within the field of public health. This study reports an evaluation of an integrated model of service delivery…

29 CFR 1614.703 - Manner and format of data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Manner and format of data. 1614.703 Section 1614.703 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Procedures Under the Notification and Federal Employee Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) §...

26 CFR 1.853-4 - Manner of making election.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) INCOME TAXES Regulated Investment Companies and Real Estate Investment Trusts § 1.853-4 Manner of... investment company must file a statement of election as part of its Federal income tax return for the taxable year. The statement of election must state that the regulated investment company elects the application...

29 CFR 1614.703 - Manner and format of data.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Manner and format of data. 1614.703 Section 1614.703 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Procedures Under the Notification and Federal Employee Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) §...

29 CFR 1614.703 - Manner and format of data.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 4 2014-07-01 2014-07-01 false Manner and format of data. 1614.703 Section 1614.703 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Procedures Under the Notification and Federal Employee Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) §...

29 CFR 1614.703 - Manner and format of data.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Manner and format of data. 1614.703 Section 1614.703 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Procedures Under the Notification and Federal Employee Antidiscrimination and Retaliation Act of 2002 (No FEAR Act) §...

14 CFR 91.13 - Careless or reckless operation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES General § 91.13... operate an aircraft in a careless or reckless manner so as to endanger the life or property of another. (b...), in a careless or reckless manner so as to endanger the life or property of another. ...

26 CFR 1.1071-4 - Manner of election.

Code of Federal Regulations, 2011 CFR

2011-04-01

... representative. In the case of a corporation, the statement shall be signed with the corporate name, followed by...) INCOME TAXES (CONTINUED) Changes to Effectuate F.c.c. Policy § 1.1071-4 Manner of election. (a) An... the corporate seal must be affixed. An election under section 1071 to reduce the basis of property and...

26 CFR 1.1071-4 - Manner of election.

Code of Federal Regulations, 2014 CFR

2014-04-01

... representative. In the case of a corporation, the statement shall be signed with the corporate name, followed by...) INCOME TAXES (CONTINUED) Changes to Effectuate F.c.c. Policy § 1.1071-4 Manner of election. (a) An... the corporate seal must be affixed. An election under section 1071 to reduce the basis of property and...

26 CFR 1.1071-4 - Manner of election.

Code of Federal Regulations, 2013 CFR

2013-04-01

... representative. In the case of a corporation, the statement shall be signed with the corporate name, followed by...) INCOME TAXES (CONTINUED) Changes to Effectuate F.c.c. Policy § 1.1071-4 Manner of election. (a) An... the corporate seal must be affixed. An election under section 1071 to reduce the basis of property and...

26 CFR 1.1071-4 - Manner of election.

Code of Federal Regulations, 2012 CFR

2012-04-01

... representative. In the case of a corporation, the statement shall be signed with the corporate name, followed by...) INCOME TAXES (CONTINUED) Changes to Effectuate F.c.c. Policy § 1.1071-4 Manner of election. (a) An... the corporate seal must be affixed. An election under section 1071 to reduce the basis of property and...

Developing proper mealtime behaviors of the institutionalized retarded.

PubMed

O'brien, F; Azrin, N H

1972-01-01

The institutionalized mentally retarded display a variety of unsanitary, disruptive, and improper table manners. A program was developed that included (1) acquisition-training of a high standard of proper table manners and (2) maintenance procedures to provide continued motivation to maintain proper mealtime behaviors and decrease improper skills. Twelve retardates received acquisition training, individually, by a combination of verbal instruction, imitation, and manual guidance. The students then ate in their group dining arrangement where the staff supervisor provided continuing approval for proper manners and verbal correction and timeout for improper manners. The results were: (1) the trained retardates showed significant improvement, whereas those untrained did not; (2) the trained retardates ate as well in the institution as non-retarded customers did in a public restaurant; (3) proper eating was maintained in the group dining setting; (4) timeout was rarely needed; (5) the program was easily administered by regular staff in a regular dining setting. The rapidity, feasibility, and effectiveness of the program suggests the program as a solution to improper mealtime behaviors by the institutionalized mentally retarded.

Isolation of exosomes from whole blood by integrating acoustics and microfluidics.

PubMed

Wu, Mengxi; Ouyang, Yingshi; Wang, Zeyu; Zhang, Rui; Huang, Po-Hsun; Chen, Chuyi; Li, Hui; Li, Peng; Quinn, David; Dao, Ming; Suresh, Subra; Sadovsky, Yoel; Huang, Tony Jun

2017-10-03

Exosomes are nanoscale extracellular vesicles that play an important role in many biological processes, including intercellular communications, antigen presentation, and the transport of proteins, RNA, and other molecules. Recently there has been significant interest in exosome-related fundamental research, seeking new exosome-based biomarkers for health monitoring and disease diagnoses. Here, we report a separation method based on acoustofluidics (i.e., the integration of acoustics and microfluidics) to isolate exosomes directly from whole blood in a label-free and contact-free manner. This acoustofluidic platform consists of two modules: a microscale cell-removal module that first removes larger blood components, followed by extracellular vesicle subgroup separation in the exosome-isolation module. In the cell-removal module, we demonstrate the isolation of 110-nm particles from a mixture of micro- and nanosized particles with a yield greater than 99%. In the exosome-isolation module, we isolate exosomes from an extracellular vesicle mixture with a purity of 98.4%. Integrating the two acoustofluidic modules onto a single chip, we isolated exosomes from whole blood with a blood cell removal rate of over 99.999%. With its ability to perform rapid, biocompatible, label-free, contact-free, and continuous-flow exosome isolation, the integrated acoustofluidic device offers a unique approach to investigate the role of exosomes in the onset and progression of human diseases with potential applications in health monitoring, medical diagnosis, targeted drug delivery, and personalized medicine.

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

PubMed Central

Wu, Mengxi; Ouyang, Yingshi; Wang, Zeyu; Zhang, Rui; Huang, Po-Hsun; Chen, Chuyi; Li, Hui; Li, Peng; Quinn, David; Dao, Ming; Suresh, Subra

2017-01-01

Exosomes are nanoscale extracellular vesicles that play an important role in many biological processes, including intercellular communications, antigen presentation, and the transport of proteins, RNA, and other molecules. Recently there has been significant interest in exosome-related fundamental research, seeking new exosome-based biomarkers for health monitoring and disease diagnoses. Here, we report a separation method based on acoustofluidics (i.e., the integration of acoustics and microfluidics) to isolate exosomes directly from whole blood in a label-free and contact-free manner. This acoustofluidic platform consists of two modules: a microscale cell-removal module that first removes larger blood components, followed by extracellular vesicle subgroup separation in the exosome-isolation module. In the cell-removal module, we demonstrate the isolation of 110-nm particles from a mixture of micro- and nanosized particles with a yield greater than 99%. In the exosome-isolation module, we isolate exosomes from an extracellular vesicle mixture with a purity of 98.4%. Integrating the two acoustofluidic modules onto a single chip, we isolated exosomes from whole blood with a blood cell removal rate of over 99.999%. With its ability to perform rapid, biocompatible, label-free, contact-free, and continuous-flow exosome isolation, the integrated acoustofluidic device offers a unique approach to investigate the role of exosomes in the onset and progression of human diseases with potential applications in health monitoring, medical diagnosis, targeted drug delivery, and personalized medicine. PMID:28923936

Functional Interactions between Newborn and Mature Neurons Leading to Integration into Established Neuronal Circuits.

PubMed

Boulanger-Weill, Jonathan; Candat, Virginie; Jouary, Adrien; Romano, Sebastián A; Pérez-Schuster, Verónica; Sumbre, Germán

2017-06-19

From development up to adulthood, the vertebrate brain is continuously supplied with newborn neurons that integrate into established mature circuits. However, how this process is coordinated during development remains unclear. Using two-photon imaging, GCaMP5 transgenic zebrafish larvae, and sparse electroporation in the larva's optic tectum, we monitored spontaneous and induced activity of large neuronal populations containing newborn and functionally mature neurons. We observed that the maturation of newborn neurons is a 4-day process. Initially, newborn neurons showed undeveloped dendritic arbors, no neurotransmitter identity, and were unresponsive to visual stimulation, although they displayed spontaneous calcium transients. Later on, newborn-labeled neurons began to respond to visual stimuli but in a very variable manner. At the end of the maturation period, newborn-labeled neurons exhibited visual tuning curves (spatial receptive fields and direction selectivity) and spontaneous correlated activity with neighboring functionally mature neurons. At this developmental stage, newborn-labeled neurons presented complex dendritic arbors and neurotransmitter identity (excitatory or inhibitory). Removal of retinal inputs significantly perturbed the integration of newborn neurons into the functionally mature tectal network. Our results provide a comprehensive description of the maturation of newborn neurons during development and shed light on potential mechanisms underlying their integration into a functionally mature neuronal circuit. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Systems biology driven software design for the research enterprise

PubMed Central

Boyle, John; Cavnor, Christopher; Killcoyne, Sarah; Shmulevich, Ilya

2008-01-01

Background In systems biology, and many other areas of research, there is a need for the interoperability of tools and data sources that were not originally designed to be integrated. Due to the interdisciplinary nature of systems biology, and its association with high throughput experimental platforms, there is an additional need to continually integrate new technologies. As scientists work in isolated groups, integration with other groups is rarely a consideration when building the required software tools. Results We illustrate an approach, through the discussion of a purpose built software architecture, which allows disparate groups to reuse tools and access data sources in a common manner. The architecture allows for: the rapid development of distributed applications; interoperability, so it can be used by a wide variety of developers and computational biologists; development using standard tools, so that it is easy to maintain and does not require a large development effort; extensibility, so that new technologies and data types can be incorporated; and non intrusive development, insofar as researchers need not to adhere to a pre-existing object model. Conclusion By using a relatively simple integration strategy, based upon a common identity system and dynamically discovered interoperable services, a light-weight software architecture can become the focal point through which scientists can both get access to and analyse the plethora of experimentally derived data. PMID:18578887

BioCO2 - a multidisciplinary, biological approach using solar energy to capture CO2 while producing H2 and high value products.

PubMed

Skjånes, Kari; Lindblad, Peter; Muller, Jiri

2007-10-01

Many areas of algae technology have developed over the last decades, and there is an established market for products derived from algae, dominated by health food and aquaculture. In addition, the interest for active biomolecules from algae is increasing rapidly. The need for CO(2) management, in particular capture and storage is currently an important technological, economical and global political issue and will continue to be so until alternative energy sources and energy carriers diminish the need for fossil fuels. This review summarizes in an integrated manner different technologies for use of algae, demonstrating the possibility of combining different areas of algae technology to capture CO(2) and using the obtained algal biomass for various industrial applications thus bringing added value to the capturing and storage processes. Furthermore, we emphasize the use of algae in a novel biological process which produces H(2) directly from solar energy in contrast to the conventional CO(2) neutral biological methods. This biological process is a part of the proposed integrated CO(2) management scheme.

Solutions to Kuessner's integral equation in unsteady flow using local basis functions

NASA Technical Reports Server (NTRS)

Fromme, J. A.; Halstead, D. W.

1975-01-01

The computational procedure and numerical results are presented for a new method to solve Kuessner's integral equation in the case of subsonic compressible flow about harmonically oscillating planar surfaces with controls. Kuessner's equation is a linear transformation from pressure to normalwash. The unknown pressure is expanded in terms of prescribed basis functions and the unknown basis function coefficients are determined in the usual manner by satisfying the given normalwash distribution either collocationally or in the complex least squares sense. The present method of solution differs from previous ones in that the basis functions are defined in a continuous fashion over a relatively small portion of the aerodynamic surface and are zero elsewhere. This method, termed the local basis function method, combines the smoothness and accuracy of distribution methods with the simplicity and versatility of panel methods. Predictions by the local basis function method for unsteady flow are shown to be in excellent agreement with other methods. Also, potential improvements to the present method and extensions to more general classes of solutions are discussed.

Large Scale Production of Densified Hydrogen Using Integrated Refrigeration and Storage

NASA Technical Reports Server (NTRS)

Notardonato, William U.; Swanger, Adam Michael; Jumper, Kevin M.; Fesmire, James E.; Tomsik, Thomas M.; Johnson, Wesley L.

2017-01-01

Recent demonstration of advanced liquid hydrogen storage techniques using Integrated Refrigeration and Storage (IRAS) technology at NASA Kennedy Space Center led to the production of large quantities of solid densified liquid and slush hydrogen in a 125,000 L tank. Production of densified hydrogen was performed at three different liquid levels and LH2 temperatures were measured by twenty silicon diode temperature sensors. System energy balances and solid mass fractions are calculated. Experimental data reveal hydrogen temperatures dropped well below the triple point during testing (up to 1 K), and were continuing to trend downward prior to system shutdown. Sub-triple point temperatures were seen to evolve in a time dependent manner along the length of the horizontal, cylindrical vessel. Twenty silicon diode temperature sensors were recorded over approximately one month for testing at two different fill levels (33 67). The phenomenon, observed at both two fill levels, is described and presented detailed and explained herein., and The implications of using IRAS for energy storage, propellant densification, and future cryofuel systems are discussed.

Application of Decision Support Tools for Integrated Water Resources Management

EPA Science Inventory

Integrated Water Resources Management (IWRM) involves “a process which promotes the coordinated development and management of water, land, and related resources in order to maximize the resultant economic and social welfare in an equitable manner without compromising the su...

TECHNOLOGY INTEGRATION FOR CONTAMINATED SITE REMEDIATION: CLEANUP GOALS & PERFORMANCE CRITERIA

EPA Science Inventory

There is a need to develop and field-test integrated remediation technologies that operate in a synergistic manner for cost-effective treatment of contaminated sites to achieve risk-based and rational endpoints. Aggressive technologies designed for rapid source-zone remediation m...

Life in a Fishbowl: Accountability and Integrity in Pharmacy Leadership

PubMed Central

Haumschild, Ryan J.; Weber, Robert J.

2014-01-01

The Director’s Forum is designed to guide pharmacy leaders in establishing patient-centered services in hospitals and health systems by providing practical information on various leadership topics. Pharmacists are bound to practice in the best interest of the patient and are obligated to act with integrity and in an ethical manner. Pharmacy directors and their leadership staff are additionally bound to manage their department with integrity. Staff often scrutinize the pharmacy director’s actions, giving the director a feeling of “life in a fishbowl.” Every action of the leader is judged in the context of personal integrity or their individual commitment to moral, spiritual, and ethical values. The objective of this article is to describe how a pharmacy leader manages this responsibility. This article addresses the pharmacy leader’s obligations to act with integrity, reviews key integrity concerns in pharmacy leadership, and provides guidance for leading and managing in the context of ethics and integrity. Pharmacy directors must always be aware that they are open to both department and public scrutiny if they do not conduct themselves in a professional manner. Being accountable for their actions and maintaining a high standard of integrity, leaders can keep the focus of their departments on the goal of patient-centered pharmacy services. PMID:25477587

40 CFR 65.118 - Alternative means of emission limitation: Enclosed-vented process units.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Equipment Leaks § 65.118... control device. Process units that are enclosed in such a manner that all emissions from equipment leaks...

Assuring structural integrity in Army systems

NASA Technical Reports Server (NTRS)

1985-01-01

The object of this study was to recommend possible improvements in the manner in which structural integrity of Army systems is assured. The elements of a structural integrity program are described, and relevant practices used in various industries and government organizations are reviewed. Some case histories of Army weapon systems are examined. The mandatory imposition of a structural integrity program patterned after the Air Force Aircraft Structural Integrity Program is recommended and the benefits of such an action are identified.

Business continuity and risk management at a strategic level: Case study of the Flemish government.

PubMed

Bouve, Joris; Steens, Herman-Peter; Ruebens, Martin

2018-01-01

The Flemish government comprises a number of different departments and agencies with the autonomy to optimise their service level in a proactive and resilient manner. Recently, the Flemish government defined four organisational values: openness, decisiveness, trust and agility. In addition, the Internal Audit Agency developed guidelines concerning internal control and organisational management, in which risk management was emphasised. In combination with goal setting and process management, this paper considers risk management as a starting point for the overall management of Flemish government entities. The paper then develops tools to support the establishment of business continuity and risk management processes. These tools fit into the organisation's strategic framework and are easy to understand, pragmatically designed and flexible in their use. The paper goes on to illustrate how the Department of the Chancellery and Public Governance is implementing BCM and risk management, and how it is integrating BCM, risk management and crisis management. It will then focus on the Flemish government's long-term strategy across the boundaries between the different entities and the question of how risk management can become a useful tool for policy makers.

Radiation damage in room-temperature data acquisition with the PILATUS 6M pixel detector.

PubMed

Rajendran, Chitra; Dworkowski, Florian S N; Wang, Meitian; Schulze-Briese, Clemens

2011-05-01

The first study of room-temperature macromolecular crystallography data acquisition with a silicon pixel detector is presented, where the data are collected in continuous sample rotation mode, with millisecond read-out time and no read-out noise. Several successive datasets were collected sequentially from single test crystals of thaumatin and insulin. The dose rate ranged between ∼ 1320 Gy s(-1) and ∼ 8420 Gy s(-1) with corresponding frame rates between 1.565 Hz and 12.5 Hz. The data were analysed for global radiation damage. A previously unreported negative dose-rate effect is observed in the indicators of global radiation damage, which showed an approximately 75% decrease in D(1/2) at sixfold higher dose rate. The integrated intensity decreases in an exponential manner. Sample heating that could give rise to the enhanced radiation sensitivity at higher dose rate is investigated by collecting data between crystal temperatures of 298 K and 353 K. UV-Vis spectroscopy is used to demonstrate that disulfide radicals and trapped electrons do not accumulate at high dose rates in continuous data collection.

Roadmap evolution: from NTRS to ITRS, from ITRS 2.0 to IRDS

NASA Astrophysics Data System (ADS)

Gargini, Paolo A.

2017-10-01

The semiconductor industry benefitted from roadmap guidance since the mid-60s. The roadmap anticipated and outlined the main needs of the semiconductor industry for years to come and identified future challenges and possible solutions. Making transistor smaller by means of advanced lithographic technologies enabled both increased integration levels and improved IC performance. The roadmap methodology allowed the removal of multiple "red brick walls". The NTRS and the ITRS constituted primarily a "bottom up" approach as standard microprocessors and memories where introduced at a blistering pace barely allowing time for system houses to integrate them in their products. The 1998 ITRS provided the vision that triggered research, development and manufacturing communities to develop a completely new transistor structure in addition to replacing aluminum interconnects with a more advanced technology. The advent of Foundries and Fabless companies transformed the electronics industry into a "top down" driven industry in the past 15 years. The ITRS adjusted to this new ecosystem and morphed into the International Roadmap for Devices and Systems (IRDS) sponsored by IEEE. The IRDS is addressing the requirements and needs of the renewed electronics industry. Furthermore, by the middle of the next decade the ability to layout integrated circuits in a 2D geometry grid will reach fundamental physical limits and the aggressive conversion to 3D architecture for integrated circuit must be pursued across the board as an avenue to continuously increasing transistor count and improving performance. EUV technology is finally approaching the manufacturing stage but with the advent of 3D monolithically integrated heterogeneous circuits approaching in the not-toodistant future should the semiconductor industry concentrate its resources on the next lithographic technology generation in order to enhance resolution or on providing a smooth transition to the new revolutionary 3D architecture of integrated circuits? It is essential for the whole semiconductor industry to come together and make fundamental choices leading to a cooperative and synchronized allocation of adequate resources to produce viable solutions that once introduced in a timely manner into manufacturing will enable the continuation of the growth of the electronic industry at a pace comparable or exceeding historical trends.

TECHNOLOGY INTEGRATION FOR CONTAMINATED SITE REMEDIATION: CLEANUP GOALS AND PERFORMANCE CRITERIA

EPA Science Inventory

There is a need to develop and field-test integrated remediation technologies that operate in a synergistic manner for cost-effective treatment of contaminated sites to achieve risk-based and rational endpoints. Aggressive technologies designed for rapid source-zone remediation m...

Logical-rules and the classification of integral dimensions: individual differences in the processing of arbitrary dimensions

PubMed Central

Blunden, Anthea G.; Wang, Tony; Griffiths, David W.; Little, Daniel R.

2015-01-01

A variety of converging operations demonstrate key differences between separable dimensions, which can be analyzed independently, and integral dimensions, which are processed in a non-analytic fashion. A recent investigation of response time distributions, applying a set of logical rule-based models, demonstrated that integral dimensions are pooled into a single coactive processing channel, in contrast to separable dimensions, which are processed in multiple, independent processing channels. This paper examines the claim that arbitrary dimensions created by factorially morphing four faces are processed in an integral manner. In two experiments, 16 participants completed a categorization task in which either upright or inverted morph stimuli were classified in a speeded fashion. Analyses focused on contrasting different assumptions about the psychological representation of the stimuli, perceptual and decisional separability, and the processing architecture. We report consistent individual differences which demonstrate a mixture of some observers who demonstrate coactive processing with other observers who process the dimensions in a parallel self-terminating manner. PMID:25620941

Microfluidic approach toward continuous and ultrafast synthesis of metal-organic framework crystals and hetero structures in confined microdroplets.

PubMed

Faustini, Marco; Kim, Jun; Jeong, Guan-Young; Kim, Jin Yeong; Moon, Hoi Ri; Ahn, Wha-Seung; Kim, Dong-Pyo

2013-10-02

Herein, we report a novel nanoliter droplet-based microfluidic strategy for continuous and ultrafast synthesis of metal-organic framework (MOF) crystals and MOF heterostructures. Representative MOF structures, such as HKUST-1, MOF-5, IRMOF-3, and UiO-66, were synthesized within a few minutes via solvothermal reactions with substantially faster kinetics in comparison to the conventional batch processes. The approach was successfully extended to the preparation of a demanding Ru3BTC2 structure that requires high-pressure hydrothermal synthesis conditions. Finally, three different types of core-shell MOF composites, i.e., Co3BTC2@Ni3BTC2, MOF-5@diCH3-MOF-5, and Fe3O4@ZIF-8, were synthesized by exploiting a unique two-step integrated microfluidic synthesis scheme in a continuous-flow mode. The synthesized MOF crystals were characterized by X-ray diffraction, scanning electron microscopy, and BET surface area measurements. In comparison with bare MOF-5, MOF-5@diCH3-MOF-5 showed enhanced structural stability in the presence of moisture, and the catalytic performance of Fe3O4@ZIF-8 was examined using Knoevenagel condensation as a probe reaction. The microfluidic strategy allowed continuous fabrication of high-quality MOF crystals and composites exhibiting distinct morphological characteristics in a time-efficient manner and represents a viable alternative to the time-consuming and multistep MOF synthesis processes.

45 CFR 1150.43 - When may the Endowment make an offset in an expedited manner?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false When may the Endowment make an offset in an expedited manner? 1150.43 Section 1150.43 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS COLLECTION OF CLAIMS...

45 CFR 1621.4 - Complaints by clients about manner or quality of legal assistance.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Complaints by clients about manner or quality of legal assistance. 1621.4 Section 1621.4 Public Welfare Regulations Relating to Public Welfare (Continued... a complainant to be accompanied by another person who may speak on that complainant's behalf; and...

45 CFR 1621.4 - Complaints by clients about manner or quality of legal assistance.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Complaints by clients about manner or quality of legal assistance. 1621.4 Section 1621.4 Public Welfare Regulations Relating to Public Welfare (Continued... a complainant to be accompanied by another person who may speak on that complainant's behalf; and...

45 CFR 1621.4 - Complaints by clients about manner or quality of legal assistance.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Complaints by clients about manner or quality of legal assistance. 1621.4 Section 1621.4 Public Welfare Regulations Relating to Public Welfare (Continued... a complainant to be accompanied by another person who may speak on that complainant's behalf; and...

45 CFR 1150.43 - When may the Endowment make an offset in an expedited manner?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false When may the Endowment make an offset in an expedited manner? 1150.43 Section 1150.43 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS COLLECTION OF CLAIMS...

45 CFR 1621.4 - Complaints by clients about manner or quality of legal assistance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Complaints by clients about manner or quality of legal assistance. 1621.4 Section 1621.4 Public Welfare Regulations Relating to Public Welfare (Continued... a complainant to be accompanied by another person who may speak on that complainant's behalf; and...

45 CFR 1621.4 - Complaints by clients about manner or quality of legal assistance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Complaints by clients about manner or quality of legal assistance. 1621.4 Section 1621.4 Public Welfare Regulations Relating to Public Welfare (Continued... a complainant to be accompanied by another person who may speak on that complainant's behalf; and...

Implementation and utilization of a comprehensive information network in an integrated private not-for-profit regional health care system

NASA Astrophysics Data System (ADS)

Long, James M., III

1995-10-01

The capacity to access, integrate, and analyze demographic, financial, and clinical data within a regional health care system represents an opportunity to ensure and enhance clinical quality and to reduce costs in a carefully planned and controlled manner. Properly used, such capability should improve health care delivery for local populations and provide the institution with a level of integration of services achieved by few health care organizations. The Baptist Health System (BHS), based in Birmingham, Alabama, is currently standardizing operating procedures among its various components and implementing a comprehensive, enterprise-wide information network. Clinical quality improvement and case management are being promulgated throughout the enterprise using a continuum-of-care model developed internally. Having successfully completed a pilot project using teleconferences for core lectures in internal medicine between two large teaching hospitals, BHS is taking advantage of enterprise- wide teleconference capability using a combination of fiberoptic (T3) and standard digital telephone (T1) transmission to speed installation and reduce the cost of implementation into two office buildings and eleven hospitals. The information system will serve to prepare BHS for the advent of managed care and other anticipated changes in health care, while ensuring continued ability to deliver high quality, cost-effective medical and health-related services.

An Airbreathing Launch Vehicle Design with Turbine-Based Low-Speed Propulsion and Dual Mode Scramjet High-Speed Propulsion

NASA Technical Reports Server (NTRS)

Moses, P. L.; Bouchard, K. A.; Vause, R. F.; Pinckney, S. Z.; Ferlemann, S. M.; Leonard, C. P.; Taylor, L. W., III; Robinson, J. S.; Martin, J. G.; Petley, D. H.

1999-01-01

Airbreathing launch vehicles continue to be a subject of great interest in the space access community. In particular, horizontal takeoff and horizontal landing vehicles are attractive with their airplane-like benefits and flexibility for future space launch requirements. The most promising of these concepts involve airframe integrated propulsion systems, in which the external undersurface of the vehicle forms part of the propulsion flowpath. Combining of airframe and engine functions in this manner involves all of the design disciplines interacting at once. Design and optimization of these configurations is a most difficult activity, requiring a multi-discipline process to analytically resolve the numerous interactions among the design variables. This paper describes the design and optimization of one configuration in this vehicle class, a lifting body with turbine-based low-speed propulsion. The integration of propulsion and airframe, both from an aero-propulsive and mechanical perspective are addressed. This paper primarily focuses on the design details of the preferred configuration and the analyses performed to assess its performance. The integration of both low-speed and high-speed propulsion is covered. Structural and mechanical designs are described along with materials and technologies used. Propellant and systems packaging are shown and the mission-sized vehicle weights are disclosed.

Application of continuous monitoring of honeybee colonies

USDA-ARS?s Scientific Manuscript database

Monitoring physical variables associated with honey bee colonies, including weight, temperature, humidity, respiratory gases, vibration, acoustics and forager traffic, in a continuous manner is becoming feasible for most researchers as the cost and size of electronic sensors and dataloggers decrease...

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2014 CFR

2014-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2013 CFR

2013-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2012 CFR

2012-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

7 CFR 97.403 - Manner of service.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS... of serving the paper is practicable, service may be by notice, published once in the Office Journal...

32 CFR 150.24 - Continuances and interlocutory matters.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Continuances and interlocutory matters. 150.24... Continuances and interlocutory matters. Except as otherwise provided in § 150.19(d), the Court, in its... matter not specifically covered by this part, in such manner as may appear to be required for a full...

32 CFR 150.24 - Continuances and interlocutory matters.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Continuances and interlocutory matters. 150.24... Continuances and interlocutory matters. Except as otherwise provided in § 150.19(d), the Court, in its... matter not specifically covered by this part, in such manner as may appear to be required for a full...

32 CFR 150.24 - Continuances and interlocutory matters.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Continuances and interlocutory matters. 150.24... Continuances and interlocutory matters. Except as otherwise provided in § 150.19(d), the Court, in its... matter not specifically covered by this part, in such manner as may appear to be required for a full...

32 CFR 150.24 - Continuances and interlocutory matters.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Continuances and interlocutory matters. 150.24... Continuances and interlocutory matters. Except as otherwise provided in § 150.19(d), the Court, in its... matter not specifically covered by this part, in such manner as may appear to be required for a full...

Dimensions of integration, continuity and longitudinality in clinical clerkships.

PubMed

Ellaway, Rachel H; Graves, Lisa; Cummings, Beth-Ann

2016-09-01

Over the past few decades, longitudinal integrated clerkships (LICs) have been proposed to address many perceived short-coming of traditional block clerkships. This growing interest in LICs has raised broader questions regarding the role of integration, continuity and longitudinality in medical education. A study with complementary theoretical and empirical dimensions was conducted to derive a more precise way of defining these three underlying concepts within the design of medical education curricula. The theoretical dimension involved a thematic review of the literature on integration, continuity and longitudinality in medical education. The empirical dimension surveyed all 17 Canadian medical schools on how they have operationalised integration, continuity and longitudinality in their undergraduate programmes. The two dimensions were iteratively synthesised to explore the meaning and expression of integration, continuity and longitudinality in medical education curriculum design. Integration, continuity and longitudinality were expressed in many ways and forms, including: integration of clinical disciplines, combined horizontal integration and vertical integration, and programme-level integration. Types of continuity included: continuity of patients, continuity of teaching, continuity of location and peer continuity. Longitudinality focused on connected or repeating episodes of training or on connecting activities, such as encounter logging across educational episodes. Twelve of the 17 schools were running an LIC of some kind, although only one school had a mandatory LIC experience. An ordinal scale of uses of integration, continuity and longitudinality during clerkships was developed, and new definitions of these concepts in the clerkship context were generated. Different clerkship designs embodied different forms and levels of integration, continuity and longitudinality. A dichotomous view of LICs and rotation-based clerkships was found not to represent current practices in Canada, which instead tended to fall along a continuum of integration, continuity and longitudinality. © 2016 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

GASP- General Aviation Synthesis Program. Volume 1: Main program. Part 1: Theoretical development

NASA Technical Reports Server (NTRS)

Hague, D.

1978-01-01

The General Aviation synthesis program performs tasks generally associated with aircraft preliminary design and allows an analyst the capability of performing parametric studies in a rapid manner. GASP emphasizes small fixed-wing aircraft employing propulsion systems varying froma single piston engine with fixed pitch propeller through twin turboprop/ turbofan powered business or transport type aircraft. The program, which may be operated from a computer terminal in either the batch or interactive graphic mode, is comprised of modules representing the various technical disciplines integrated into a computational flow which ensures that the interacting effects of design variables are continuously accounted for in the aircraft sizing procedure. The model is a useful tool for comparing configurations, assessing aircraft performance and economics, performing tradeoff and sensitivity studies, and assessing the impact of advanced technologies on aircraft performance and economics.

Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

PubMed Central

Plikus, Maksim V.; Baker, Ruth E.; Chen, Chih-Chiang; Fare, Clyde; de la Cruz, Damon; Andl, Thomas; Maini, Philip K.; Millar, Sarah E.; Widelitz, Randall; Chuong, Cheng-Ming

2012-01-01

Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs. PMID:21527712

3D Printed Multimaterial Microfluidic Valve

PubMed Central

Patrick, William G.; Sharma, Sunanda; Kong, David S.; Oxman, Neri

2016-01-01

We present a novel 3D printed multimaterial microfluidic proportional valve. The microfluidic valve is a fundamental primitive that enables the development of programmable, automated devices for controlling fluids in a precise manner. We discuss valve characterization results, as well as exploratory design variations in channel width, membrane thickness, and membrane stiffness. Compared to previous single material 3D printed valves that are stiff, these printed valves constrain fluidic deformation spatially, through combinations of stiff and flexible materials, to enable intricate geometries in an actuated, functionally graded device. Research presented marks a shift towards 3D printing multi-property programmable fluidic devices in a single step, in which integrated multimaterial valves can be used to control complex fluidic reactions for a variety of applications, including DNA assembly and analysis, continuous sampling and sensing, and soft robotics. PMID:27525809

Clarification of the Use of Biological Data and Information in the 2002 Integrated Water Quality Monitoring and Assessment Report Guidance

EPA Pesticide Factsheets

The memorandum modifies the 2002 Integrated Water Quality Monitoring and Assessment Report Guidance to provide clarity and promote consistency in the manner in which states use biological data and information in developing their 2002 submissions.

In-vivo continuous monitoring of mixed venous oxygen saturation by photoacoustic transesophageal echocardiography (Conference Presentation)

NASA Astrophysics Data System (ADS)

Li, Li; Subramaniam, Balachundhar; Aguirre, Aaron D.; Andrawes, Michael N.; Tearney, Guillermo J.

2016-02-01

Mixed venous oxygen saturation (SvO2), measured from pulmonary arteries, is a gold-standard measure of the dynamic balance between the oxygen supply and demand in the body. In critical care, continuous monitoring of SvO2 plays a vital role in early detection of circulatory shock and guiding goal-oriented resuscitation. In current clinical practice, SvO2 is measured by invasive pulmonary artery catheters (PAC), which are associated with a 10% risk of severe complications. To address the unmet clinical need for a non-invasive SvO2 monitor, we are developing a new technology termed photoacoustic transesophageal echocardiography (PA-TEE). PA-TEE integrates transesophageal echocardiography with photoacoustic oximetry, and enables continuous assessment of SvO2 through an esophageal probe that can be inserted into the body in a minimally invasive manner. We have constructed a clinically translatable PA-TEE prototype, which features a mobile OPO laser, a modified ultrasonography console and a dual-modality esophageal probe. Comprised of a rotatable acoustic array detector, a flexible optical fiber bundle and a light-integrating acoustic lens, the oximetric probe has an outer diameter smaller than 15 mm and will be tolerable for most patients. Through custom-made C++/Qt software, our device acquires and displays ultrasonic and photoacoustic images in real time to guide the deployment of the probe. SvO2 is calculated on-line and updated every second. PA-TEE has now been used to evaluate SvO2 in living swine. Our findings show that changing the fraction of oxygen in the inspired gas modulates SvO2 measured by PA-TEE. Statistic comparison between SvO2 measurements from PA-TEE in vivo the gold-standard laboratorial analysis on blood samples drawn from PACs will be presented.

7 CFR 160.31 - Time and manner of sampling.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) NAVAL STORES REGULATIONS AND..., samples of naval stores to be used for official inspection and certification shall be taken direct from...

Antibacterial Effect of Gallic Acid against Aeromonas hydrophila and Aeromonas sobria Through Damaging Membrane Integrity.

PubMed

Lu, Jing; Wang, Zhenning; Ren, Mengrou; Huang, Guoren; Fang, Baochen; Bu, Xiujuan; Liu, Yanhui; Guan, Shuang

In the study, we investigated the antibacterial activity and mechanism of gallic acid against Aeromonas hydrophila and Aeromonas sobria. Gallic acid showed strong antimicrobial activity against the two bacteria. Furthermore, the antibacterial mechanism of gallic acid (0, 3, 6, 12 mM) was performed by membrane integrity assay and scanning electron microscopy (SEM) assay. The results showed that gallic acid notably increased the released material absorption value at 260, 280 nm and electric conductivity in a dose-dependent manner. Moreover, the SEM assay showed that gallic acid induced severe shrink of bacterial intima and irregular morphology in a dose-dependent manner. The SDS-PAGE profiles further confirmed that gallic acid could damage bacterial cells. These results indicated gallic acid exhibited antibacterial effect by destroying membrane integrity of A. hydrophila and A. sobria. Hence, gallic acid has great potential as a new natural food preservative in food fresh-keeping and storage.

Cycling with BRCA2 from DNA repair to mitosis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Hyunsook, E-mail: HL212@snu.ac.kr

Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome maintenance. The functions of BRCA2 in DNA repair and homology-directed recombination (HDR) have been reviewed numerous times. Here, I will briefly go through the functions of BRCA2 in HDR and focus on the emerging roles of BRCA2 in telomere homeostasis and mitosis, then discuss how BRCA2 exerts distinct functions in a cell-cycle specific manner inmore » the maintenance of genomic integrity. - Highlights: • BRCA2 is a multifaceted tumor suppressor and is crucial in genetic integrity. • BRCA2 exerts distinct functions in cell cycle-specific manner. • Mitotic kinases regulate diverse functions of BRCA2 in mitosis and cytokinesis.« less

Schizophrenia: A Cognitive Model and Its Implications for Psychological Intervention.

ERIC Educational Resources Information Center

Hemsley, David R.

1996-01-01

Proposes a cognitive model of schizophrenia stating that schizophrenic behavior is caused by a disturbance in sensory input and stored material integration. Cites research to support this model. Outlines the manner in which a disturbance in sensory input integration relates to schizophrenic symptoms and discusses the model's relevance for…

UVA Irradiation of Dysplastic Keratinocytes: Oxidative Damage versus Antioxidant Defense

PubMed Central

Nechifor, Marina T.; Niculiţe, Cristina M.; Urs, Andreea O.; Regalia, Teodor; Mocanu, Mihaela; Popescu, Alexandra; Manda, Gina; Dinu, Diana; Leabu, Mircea

2012-01-01

UVA affects epidermal cell physiology in a complex manner, but the harmful effects have been studied mainly in terms of DNA damage, mutagenesis and carcinogenesis. We investigated UVA effects on membrane integrity and antioxidant defense of dysplastic keratinocytes after one and two hours of irradiation, both immediately after exposure, and 24 h post-irradiation. To determine the UVA oxidative stress on cell membrane, lipid peroxidation was correlated with changes in fatty acid levels. Membrane permeability and integrity were assessed by propidium iodide staining and lactate dehydrogenase release. The effects on keratinocyte antioxidant protection were investigated in terms of catalase activity and expression. Lipid peroxidation increased in an exposure time-dependent manner. UVA exposure decreased the level of polyunsaturated fatty acids, which gradually returned to its initial value. Lactate dehydrogenase release showed a dramatic loss in membrane integrity after 2 h minimum of exposure. The cell ability to restore membrane permeability was noted at 24 h post-irradiation (for one hour exposure). Catalase activity decreased in an exposure time-dependent manner. UVA-irradiated dysplastic keratinocytes developed mechanisms leading to cell protection and survival, following a non-lethal exposure. The surviving cells gained an increased resistance to apoptosis, suggesting that their pre-malignant status harbors an abnormal ability to control their fate. PMID:23222638

The Need for Specialty Curricula Based on Core Competencies: A White Paper of the Conjoint Committee on Continuing Medical Education

ERIC Educational Resources Information Center

Jackson, Marcia J.; Gallis, Harry A.; Gilman, Stuart C.; Grossman, Michael; Holzman, Gerald B.; Marquis, Damon; Trusky, Sandra K.

2007-01-01

At present there is no curriculum to guide physician lifelong learning in a prescribed, deliberate manner. The Conjoint Committee on Continuing Medical Education, a group representing 16 major stakeholder organizations in continuing medical education, recommends that each specialty society and corresponding board reach consensus on the…

Event-driven processing for hardware-efficient neural spike sorting

NASA Astrophysics Data System (ADS)

Liu, Yan; Pereira, João L.; Constandinou, Timothy G.

2018-02-01

Objective. The prospect of real-time and on-node spike sorting provides a genuine opportunity to push the envelope of large-scale integrated neural recording systems. In such systems the hardware resources, power requirements and data bandwidth increase linearly with channel count. Event-based (or data-driven) processing can provide here a new efficient means for hardware implementation that is completely activity dependant. In this work, we investigate using continuous-time level-crossing sampling for efficient data representation and subsequent spike processing. Approach. (1) We first compare signals (synthetic neural datasets) encoded with this technique against conventional sampling. (2) We then show how such a representation can be directly exploited by extracting simple time domain features from the bitstream to perform neural spike sorting. (3) The proposed method is implemented in a low power FPGA platform to demonstrate its hardware viability. Main results. It is observed that considerably lower data rates are achievable when using 7 bits or less to represent the signals, whilst maintaining the signal fidelity. Results obtained using both MATLAB and reconfigurable logic hardware (FPGA) indicate that feature extraction and spike sorting accuracies can be achieved with comparable or better accuracy than reference methods whilst also requiring relatively low hardware resources. Significance. By effectively exploiting continuous-time data representation, neural signal processing can be achieved in a completely event-driven manner, reducing both the required resources (memory, complexity) and computations (operations). This will see future large-scale neural systems integrating on-node processing in real-time hardware.

26 CFR 1.468A-7T - Manner of and time for making election (temporary).

Code of Federal Regulations, 2010 CFR

2010-04-01

... TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Taxable Year for Which Deductions Taken § 1.468A... 468A” typed or legibly printed at the top of the first page. (2) The electing taxpayer's name, address...

47 CFR 69.310 - Capital leases.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Capital leases. 69.310 Section 69.310 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) ACCESS CHARGES... prescribed for similar plant costs or shall be apportioned in the same manner as Account 2001. ...

47 CFR 69.310 - Capital leases.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 3 2011-10-01 2011-10-01 false Capital leases. 69.310 Section 69.310 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) ACCESS CHARGES... prescribed for similar plant costs or shall be apportioned in the same manner as Account 2001. ...

40 CFR 62.14490 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND... living organisms and their products, including vaccines, cultures, etc., intended for use in diagnosing..., process equipment, or a process to operate in a normal or usual manner. Failures that are caused, in part...

40 CFR 62.14490 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND... living organisms and their products, including vaccines, cultures, etc., intended for use in diagnosing..., process equipment, or a process to operate in a normal or usual manner. Failures that are caused, in part...

40 CFR 62.14490 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND..., including vaccines, cultures, etc., intended for use in diagnosing, immunizing, or treating humans or..., process equipment, or a process to operate in a normal or usual manner. Failures that are caused, in part...

7 CFR 1940.307 - Environmental responsibilities within the State Office.

Code of Federal Regulations, 2010 CFR

2010-01-01

... any unresolved or difficult environmental issues in a timely manner; and (3) Incorporate into projects... 7 Agriculture 13 2010-01-01 2009-01-01 true Environmental responsibilities within the State Office..., DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) GENERAL Environmental Program § 1940...

47 CFR 69.411 - Other expenses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Other expenses. 69.411 Section 69.411 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) ACCESS CHARGES... interexchange category and all access elements in the same manner as § 69.309 Other investment. [62 FR 31639...

Autonomous Assembly of Modular Structures in Space and on Extraterrestrial Locations

NASA Astrophysics Data System (ADS)

Alhorn, Dean C.

2005-02-01

The new U.S. National Vision for Space Exploration requires many new enabling technologies to accomplish the goals of space commercialization and returning humans to the moon and extraterrestrial environments. Traditionally, flight elements are complete sub-systems requiring humans to complete the integration and assembly. These bulky structures also require the use of heavy launch vehicles to send the units to a desired location. This philosophy necessitates a high degree of safety, numerous space walks at a significant cost. Future space mission costs must be reduced and safety increased to reasonably achieve exploration goals. One proposed concept is the autonomous assembly of space structures. This concept is an affordable, reliable solution to in-space and extraterrestrial assembly. Assembly is autonomously performed when two components join after determining that specifications are correct. Local sensors continue monitor joint integrity post assembly, which is critical for safety and structural reliability. Achieving this concept requires a change in space structure design philosophy and the development of innovative technologies to perform autonomous assembly. Assembly of large space structures will require significant numbers of integrity sensors. Thus simple, low-cost sensors are integral to the success of this concept. This paper addresses these issues and proposes a novel concept for assembling space structures autonomously. Core technologies required to achieve in space assembly are presented. These core technologies are critical to the goal of utilizing space in a cost efficient and safe manner. Additionally, these novel technologies can be applied to other systems both on earth and extraterrestrial environments.

Light-induced spatial control of pH-jump reaction at smart gel interface.

PubMed

Techawanitchai, Prapatsorn; Ebara, Mitsuhiro; Idota, Naokazu; Aoyagi, Takao

2012-11-01

We proposed here a 'smart' control of an interface movement of proton diffusion in temperature- and pH-responsive hydrogels using a light-induced spatial pH-jump reaction. A photoinitiated proton-releasing reaction of o-nitrobenzaldehyde (NBA) was integrated into poly(N-isopropylacrylamide-o-2-carboxyisopropylacrylamide) (P(NIPAAm-co-CIPAAm)) hydrogels. NBA-integrated hydrogels demonstrated quick release of proton upon UV irradiation, allowing the pH inside the gel to decrease below the pK(a) of P(NIPAAm-co-CIPAAm) within a minute. The NBA-integrated gel was shown to shrink rapidly upon UV irradiation without polymer "skin layer" formation due to a uniform decrease of pH inside the gel. Spatial control of gel shrinking was also created by irradiating UV light to a limited region of the gel through a photomask. The interface of proton diffusion ("active interface") gradually moved toward non-illuminated area. The apparent position of "active interface", however, did not change remarkably above the LCST, while protons continuously diffused outward direction. This is because the "active interface" also moved inward direction as gel shrank above the LCST. As a result, slow movement of the apparent interface was observed. The NBA-integrated gel was also successfully employed for the controlled release of an entrapped dextran in a light controlled manner. This system is highly promising as smart platforms for triggered and programmed transportation of drugs. Copyright © 2011 Elsevier B.V. All rights reserved.

Characterizing regional-scale temporal evolution of air dose rates after the Fukushima Daiichi Nuclear Power Plant accident.

PubMed

Wainwright, Haruko M; Seki, Akiyuki; Mikami, Satoshi; Saito, Kimiaki

2018-09-01

In this study, we quantify the temporal changes of air dose rates in the regional scale around the Fukushima Dai-ichi Nuclear Power Plant in Japan, and predict the spatial distribution of air dose rates in the future. We first apply the Bayesian geostatistical method developed by Wainwright et al. (2017) to integrate multiscale datasets including ground-based walk and car surveys, and airborne surveys, all of which have different scales, resolutions, spatial coverage, and accuracy. This method is based on geostatistics to represent spatial heterogeneous structures, and also on Bayesian hierarchical models to integrate multiscale, multi-type datasets in a consistent manner. We apply this method to the datasets from three years: 2014 to 2016. The temporal changes among the three integrated maps enables us to characterize the spatiotemporal dynamics of radiation air dose rates. The data-driven ecological decay model is then coupled with the integrated map to predict future dose rates. Results show that the air dose rates are decreasing consistently across the region. While slower in the forested region, the decrease is particularly significant in the town area. The decontamination has contributed to significant reduction of air dose rates. By 2026, the air dose rates will continue to decrease, and the area above 3.8 μSv/h will be almost fully contained within the non-residential forested zone. Copyright © 2018 Elsevier Ltd. All rights reserved.

Autonomous Assembly of Modular Structures in Space and on Extraterrestrial Locations

NASA Technical Reports Server (NTRS)

Alhorn, Dean C.

2005-01-01

The new U.S. National Vision for Space Exploration requires many new enabling technologies to accomplish the goals of space commercialization and returning humans to the moon and extraterrestrial environments. Traditionally, flight elements are complete subsystems requiring humans to complete the integration and assembly. These bulky structures also require the use of heavy launch vehicles to send the units to a desired location. This philosophy necessitates a high degree of safety, numerous space walks at a significant cost. Future space mission costs must be reduced and safety increased to reasonably achieve exploration goals. One proposed concept is the autonomous assembly of space structures. This concept is an affordable, reliable solution to in-space and extraterrestrial assembly. Assembly is autonomously performed when two components join after determining that specifications are correct. Local sensors continue monitor joint integrity post assembly, which is critical for safety and structural reliability. Achieving this concept requires a change in space structure design philosophy and the development of innovative technologies to perform autonomous assembly. Assembly of large space structures will require significant numbers of integrity sensors. Thus simple, low-cost sensors are integral to the success of this concept. This paper addresses these issues and proposes a novel concept for assembling space structures autonomously. Core technologies required to achieve in space assembly are presented. These core technologies are critical to the goal of utilizing space in a cost efficient and safe manner. Additionally, these novel technologies can be applied to other systems both on earth and extraterrestrial environments.

Electronic integrated disease surveillance system and pathogen asset control system.

PubMed

Wahl, Tom G; Burdakov, Aleksey V; Oukharov, Andrey O; Zhilokov, Azamat K

2012-06-20

Electronic Integrated Disease Surveillance System (EIDSS) has been used to strengthen and support monitoring and prevention of dangerous diseases within One Health concept by integrating veterinary and human surveillance, passive and active approaches, case-based records including disease-specific clinical data based on standardised case definitions and aggregated data, laboratory data including sample tracking linked to each case and event with test results and epidemiological investigations. Information was collected and shared in secure way by different means: through the distributed nodes which are continuously synchronised amongst each other, through the web service, through the handheld devices. Electronic Integrated Disease Surveillance System provided near real time information flow that has been then disseminated to the appropriate organisations in a timely manner. It has been used for comprehensive analysis and visualisation capabilities including real time mapping of case events as these unfold enhancing decision making. Electronic Integrated Disease Surveillance System facilitated countries to comply with the IHR 2005 requirements through a data transfer module reporting diseases electronically to the World Health Organisation (WHO) data center as well as establish authorised data exchange with other electronic system using Open Architecture approach. Pathogen Asset Control System (PACS) has been used for accounting, management and control of biological agent stocks. Information on samples and strains of any kind throughout their entire lifecycle has been tracked in a comprehensive and flexible solution PACS.Both systems have been used in a combination and individually. Electronic Integrated Disease Surveillance System and PACS are currently deployed in the Republics of Kazakhstan, Georgia and Azerbaijan as a part of the Cooperative Biological Engagement Program (CBEP) sponsored by the US Defense Threat Reduction Agency (DTRA).

Lean Middleware

NASA Technical Reports Server (NTRS)

Maluf, David A.; Bell, David g.; Ashish, Naveen

2005-01-01

This paper describes an approach to achieving data integration across multiple sources in an enterprise, in a manner that is cost efficient and economically scalable. We present an approach that does not rely on major investment in structured, heavy-weight database systems for data storage or heavy-weight middleware responsible for integrated access. The approach is centered around pushing any required data structure and semantics functionality (schema) to application clients, as well as pushing integration specification and functionality to clients where integration can be performed on-the-fly .

Automated Ontology Alignment with Fuselets for Community of Interest (COI) Integration

DTIC Science & Technology

2008-09-01

Search Example ............................................................................... 22 Figure 8 - Federated Search Example Revisited...integrating information from various sources through a single query. This is the traditional federated search problem, where the sources don’t...Figure 7 - Federated Search Example For the data sources in the graphic above, the ontologies align in a fairly straightforward manner

Cross-species integration of human health and ecological endpoints into risk assessment using the Aggregate Exposure Pathway and Adverse Outcome Pathway frameworks

EPA Science Inventory

Exposure to environmental contaminants can influence both human health and ecological endpoints. Chemical risk assessments combine exposure and toxicity data to estimate the likelihood of adverse outcomes for these endpoints, but are rarely conducted in a manner that integrates ...

The Integration of Christian Spirituality and Learning in Counselor Education: A Lesson from Adler.

ERIC Educational Resources Information Center

McCurdy, Kenneth

The relationship between spirituality, and counseling and psychotherapy has been given increased attention in recent years. The author suggests that the teachings of Alfred Adler may assist counselor educators in integrating faith and learning in an unimposing manner respectful of religious tenets, focusing on spirituality, which can include…

7 CFR 201.53 - Source of seeds for germination.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT... be used. The whole sample must be well mixed and divided in such a manner as to get a completely...

7 CFR 201.53 - Source of seeds for germination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT... be used. The whole sample must be well mixed and divided in such a manner as to get a completely...

40 CFR Table 3 to Subpart Bbbbbb... - Applicability of General Provisions

Code of Federal Regulations, 2010 CFR

2010-07-01

... and Maintenance Maintain monitoring system in a manner consistent with good air pollution control... pollution control equipment; maintenance on air pollution control equipment; actions during SSM Yes. § 63.10... (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

IRIS++ database: Merging of IRIS + Mark-1 + LOWL

NASA Astrophysics Data System (ADS)

Salabert, D.; Fossat, E.; Gelly, B.; Tomczyk, S.; Pallé, P.; Jiménez-Reyes, S. J.; Cacciani, A.; Corbard, T.; Ehgamberdiev, S.; Grec, G.; Hoeksema, J. T.; Kholikov, S.; Lazrek, M.; Schmider, F. X.

2002-08-01

The IRIS network has been operated continuously since July 1st 1989. To date, it has acquired more than a complete solar cycle of full-disk helioseismic data which has been used to constrain the structure and rotation of the deep solar interior. However, the duty cycle of the network data has never reached initial expectations. To improve this situation, several cooperations have been developed with teams collecting observations with similar instruments. This paper demonstrates that we are able to merge data from these different instruments in a consistent manner resulting in a very significant improvement in network duty cycle over more than one solar cycle initiating what we call the IRIS++ network. The integrated radial velocities from the IRIS++ database (1989 to 1999) are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/390/717

Accurate evaluation and analysis of functional genomics data and methods

PubMed Central

Greene, Casey S.; Troyanskaya, Olga G.

2016-01-01

The development of technology capable of inexpensively performing large-scale measurements of biological systems has generated a wealth of data. Integrative analysis of these data holds the promise of uncovering gene function, regulation, and, in the longer run, understanding complex disease. However, their analysis has proved very challenging, as it is difficult to quickly and effectively assess the relevance and accuracy of these data for individual biological questions. Here, we identify biases that present challenges for the assessment of functional genomics data and methods. We then discuss evaluation methods that, taken together, begin to address these issues. We also argue that the funding of systematic data-driven experiments and of high-quality curation efforts will further improve evaluation metrics so that they more-accurately assess functional genomics data and methods. Such metrics will allow researchers in the field of functional genomics to continue to answer important biological questions in a data-driven manner. PMID:22268703

Longevity and optimal health: working toward an integrative methodology.

PubMed

Oz, Mehmet; Tallent, Jeremy

2009-08-01

Efforts to foster a research dialogue between traditions as seemingly divergent as Western biomedicine and Indo-Tibetan medical and self-regulatory practice require a carefully conceived set of methodological guidelines. To approach a useful methodology, some specific structural differences between traditions must be negotiated, for example the Indo-Tibetan emphasis on holism in medicine and ethics, which appears to run contrary to Western trends toward specialization in both clinical and research contexts. Certain pitfalls must be avoided as well, including the tendency to appropriate elements of either tradition in a reductionistic manner. However, research methods offering creative solutions to these problems are now emerging, successfully engendering quantitative insight without subsuming one tradition within the terms of the other. Only through continued, creative work exploring both the potentials and limitations of this dialogue can collaborative research insight be attained, and an appropriate and useful set of methodological principles be approached.

Large scale production of densified hydrogen to the triple point and below

NASA Astrophysics Data System (ADS)

Swanger, A. M.; Notardonato, W. U.; E Fesmire, J.; Jumper, K. M.; Johnson, W. L.; Tomsik, T. M.

2017-12-01

Recent demonstration of advanced liquid hydrogen storage techniques using Integrated Refrigeration and Storage technology at NASA Kennedy Space Center led to the production of large quantities of densified liquid and slush hydrogen in a 125,000 L tank. Production of densified hydrogen was performed at three different liquid levels and LH2 temperatures were measured by twenty silicon diode temperature sensors. Overall densification performance of the system is explored, and solid mass fractions are calculated. Experimental data reveal hydrogen temperatures dropped well below the triple point during testing, and were continuing to trend downward prior to system shutdown. Sub-triple point temperatures were seen to evolve in a time dependent manner along the length of the horizontal, cylindrical vessel. The phenomenon, observed at two fill levels, is detailed herein. The implications of using IRAS for energy storage, propellant densification, and future cryofuel systems are discussed.

The challenges of sequencing by synthesis.

PubMed

Fuller, Carl W; Middendorf, Lyle R; Benner, Steven A; Church, George M; Harris, Timothy; Huang, Xiaohua; Jovanovich, Stevan B; Nelson, John R; Schloss, Jeffery A; Schwartz, David C; Vezenov, Dmitri V

2009-11-01

DNA sequencing-by-synthesis (SBS) technology, using a polymerase or ligase enzyme as its core biochemistry, has already been incorporated in several second-generation DNA sequencing systems with significant performance. Notwithstanding the substantial success of these SBS platforms, challenges continue to limit the ability to reduce the cost of sequencing a human genome to $100,000 or less. Achieving dramatically reduced cost with enhanced throughput and quality will require the seamless integration of scientific and technological effort across disciplines within biochemistry, chemistry, physics and engineering. The challenges include sample preparation, surface chemistry, fluorescent labels, optimizing the enzyme-substrate system, optics, instrumentation, understanding tradeoffs of throughput versus accuracy, and read-length/phasing limitations. By framing these challenges in a manner accessible to a broad community of scientists and engineers, we hope to solicit input from the broader research community on means of accelerating the advancement of genome sequencing technology.

Needs and Problems of Posbindu Program: Community Health Volunteers Perspective

NASA Astrophysics Data System (ADS)

Putri, S. T.; Andriyani, S.

2018-01-01

Posbindu is a form of public participation to conduct early detection and monitoring of risk factors for non-communicable diseases(NCD), and where it was carried out in as an integrated manner, routine and periodic event. This paper aims to investigates the needs and problems on Posbindu Program based on community health volunteers(CHVs) perspective. This study used descriptive qualitative method by open ended questions. Content analysis using to explicating the result. There are 3 theme finding about elderly needs in Posbindu; medical care, support group community, and health education. We found four theme problems which in Posbindu program: low motivation from elderly, Inadequate of facilities, physical disability, failed communication. To be effective in Posbindu program, all the stakeholders have reached consensus on the Posbindu program as elderly need. CHVs need given wide knowledge about early detection, daily care, control disease continuously so that the elderly keep feeling the advantages of coming to the Posbindu.

Large Scale Production of Densified Hydrogen to the Triple Point and Below

NASA Technical Reports Server (NTRS)

Swanger, A. M.; Notardonato, W. U.; Fesmire, J. E.; Jumper, K. M.; Johnson, W. L.; Tomsik, T. M.

2017-01-01

Recent demonstration of advanced liquid hydrogen storage techniques using Integrated Refrigeration and Storage technology at NASA Kennedy Space Center led to the production of large quantities of densified liquid and slush hydrogen in a 125,000 L tank. Production of densified hydrogen was performed at three different liquid levels and LH2 temperatures were measured by twenty silicon diode temperature sensors. Overall densification performance of the system is explored, and solid mass fractions are calculated. Experimental data reveal hydrogen temperatures dropped well below the triple point during testing, and were continuing to trend downward prior to system shutdown. Sub-triple point temperatures were seen to evolve in a time dependent manner along the length of the horizontal, cylindrical vessel. The phenomenon, observed at two fill levels, is detailed herein. The implications of using IRAS for energy storage, propellant densification, and future cryofuel systems are discussed.

Frequency-duration analysis of dissolved-oxygen concentrations in two southwestern Wisconsin streams

USGS Publications Warehouse

Greb, Steven R.; Graczyk, David J.

2007-01-01

Historically, dissolved-oxygen (DO) data have been collected in the same manner as other water-quality constituents, typically at infrequent intervals as a grab sample or an instantaneous meter reading. Recent years have seen an increase in continuous water-quality monitoring with electronic dataloggers. This new technique requires new approaches in the statistical analysis of the continuous record. This paper presents an application of frequency-duration analysis to the continuous DO records of a cold and a warm water stream in rural southwestern Wisconsin. This method offers a quick, concise way to summarize large time-series data bases in an easily interpretable manner. Even though the two streams had similar mean DO concentrations, frequency-duration analyses showed distinct differences in their DO-concentration regime. This type of analysis also may be useful in relating DO concentrations to biological effects and in predicting low DO occurrences.

The Munroe-Meyer Approach: Continuous Integration of Didactic Instruction, Research, and Clinical Practice.

PubMed

Zangrillo, Amanda N; Warzak, William J; Volkert, Valerie M; Valleley, Rachel J; Shriver, Mark D; Rodriguez, Nicole M; Roberts, Holly J; Piazza, Cathleen C; Peterson, Kathryn M; Milnes, Suzanne M; Menousek, Kathryn M; Mathews, Terri L; Luczynski, Kevin C; Kupzyk, Sara S; Kuhn, Brett R; Higgins, William J; Grennan, Allison O; Greer, Brian D; Fisher, Wayne W; Evans, Joseph H; Allen, Keith D

2016-05-01

Increased demand for applied behavior analysis (ABA) services has increased the need for additional masters-level practitioners and doctoral-level academicians and clinical directors. Based on these needs, the University of Nebraska Medical Center's (UNMC) Munroe-Meyer Institute has developed a PhD program. The academic structure at UNMC allowed us to create our PhD program in a relatively quick and efficient manner. Our PhD program has many unique features, including (a) close integration of didactic instruction with clinical and research training provided by leading experts in ABA in which students immediately apply concepts introduced in the classroom during coordinated clinical and research practica; (b) structured grant writing training in which students learn to write and submit an NIH-level grant; (c) financial support in the form of a stipend of $23,400 per year, free health benefits, and a full-tuition waiver for up to 12 credits per semester for UNMC courses (a benefits package worth approximately $50,000 per year for an out-of-state student); and (d) encouragement and financial support to present papers at local, regional, and national behavior analysis conferences.

Integrated RF/Optical Interplanetary Networking Preliminary Explorations and Empirical Results

NASA Technical Reports Server (NTRS)

Raible, Daniel E.; Hylton, Alan G.

2012-01-01

Over the last decade interplanetary telecommunication capabilities have been significantly expanded--specifically in support of the Mars exploration rover and lander missions. NASA is continuing to drive advances in new, high payoff optical communications technologies to enhance the network to Gbps performance from Mars, and the transition from technology demonstration to operational system is examined through a hybrid RF/optical approach. Such a system combines the best features of RF and optical communications considering availability and performance to realize a dual band trunk line operating within characteristic constraints. Disconnection due to planetary obscuration and solar conjunction, link delays, timing, ground terminal mission congestion and scheduling policy along with space and atmospheric weather disruptions all imply the need for network protocol solutions to ultimately manage the physical layer in a transparent manner to the end user. Delay Tolerant Networking (DTN) is an approach under evaluation which addresses these challenges. A multi-hop multi-path hybrid RF and optical test bed has been constructed to emulate the integrated deep space network and to support protocol and hardware refinement. Initial experimental results characterize several of these challenges and evaluate the effectiveness of DTN as a solution to mitigate them.

Polybenzoxazole Nanofiber-Reinforced Moisture-Responsive Soft Actuators.

PubMed

Chen, Meiling; Frueh, Johannes; Wang, Daolin; Lin, Xiankun; Xie, Hui; He, Qiang

2017-04-10

Hydromorphic biological systems, such as morning glory flowers, pinecones, and awns, have inspired researchers to design moisture-sensitive soft actuators capable of directly converting the change of moisture into motion or mechanical work. Here, we report a moisture-sensitive poly(p-phenylene benzobisoxazole) nanofiber (PBONF)-reinforced carbon nanotube/poly(vinyl alcohol) (CNT/PVA) bilayer soft actuator with fine performance on conductivity and mechanical properties. The embedded PBONFs not only assist CNTs to form a continuous, conductive film, but also enhance the mechanical performance of the actuators. The PBONF-reinforced CNT/PVA bilayer actuators can unsymmetrically adsorb and desorb water, resulting in a reversible deformation. More importantly, the actuators show a pronounced increase of conductivity due to the deformation induced by the moisture change, which allows the integration of a moisture-sensitive actuator and a humidity sensor. Upon changing the environmental humidity, the actuators can respond by the deformation for shielding and report the humidity change in a visual manner, which has been demonstrated by a tweezer and a curtain. Such nanofiber-reinforced bilayer actuators with the sensing capability should hold considerable promise for the applications such as soft robots, sensors, intelligent switches, integrated devices, and material storage.

MEMS-Electronic-Photonic Heterogeneous Integrated FMCW Ladar Source

DTIC Science & Technology

2015-12-18

CMOS  ICs  in  a  seamless  manner,  and...the   heterogeneous   integration   is   to   leverage   on   the   available   foundry   capabilities   ( CMOS   and...dies”   or   “known  good  wafers”).  We  have  adopted  a  three-­‐dimensional  (3D)  integration  strategy:  The   CMOS

26 CFR 1.853-4 - Manner of making election.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.853... year, a regulated investment company must file a statement of election as part of its Federal income tax return for the taxable year. The statement of election must state that the regulated investment...

26 CFR 1.853-4 - Manner of making election.

Code of Federal Regulations, 2013 CFR

2013-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.853... year, a regulated investment company must file a statement of election as part of its Federal income tax return for the taxable year. The statement of election must state that the regulated investment...

26 CFR 1.853-4 - Manner of making election.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.853... year, a regulated investment company must file a statement of election as part of its Federal income tax return for the taxable year. The statement of election must state that the regulated investment...

26 CFR 1.853-4 - Manner of making election.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.853... year, a regulated investment company must file a statement of election as part of its Federal income tax return for the taxable year. The statement of election must state that the regulated investment...

40 CFR Table 3 to Subpart Bbbbbb... - Applicability of General Provisions

Code of Federal Regulations, 2012 CFR

2012-07-01

... Maintain monitoring system in a manner consistent with good air pollution control practices Yes. § 63.8(c...) Maintenance records Recordkeeping of maintenance on air pollution control and monitoring equipment Yes. § 63... (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR 63.1159 - Operational and equipment standards for existing, new, or reconstructed sources.

Code of Federal Regulations, 2014 CFR

2014-07-01

... atmosphere shall be equipped with a local fume capture system, ventilated through an air pollution control... pollution control equipment and monitoring equipment in a manner consistent with safety and good air... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS...

40 CFR 63.1159 - Operational and equipment standards for existing, new, or reconstructed sources.

Code of Federal Regulations, 2013 CFR

2013-07-01

... atmosphere shall be equipped with a local fume capture system, ventilated through an air pollution control... pollution control equipment and monitoring equipment in a manner consistent with safety and good air... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS...

40 CFR Table 3 to Subpart Bbbbbb... - Applicability of General Provisions

Code of Federal Regulations, 2011 CFR

2011-07-01

... Maintain monitoring system in a manner consistent with good air pollution control practices Yes. § 63.8(c...) Maintenance records Recordkeeping of maintenance on air pollution control and monitoring equipment Yes. § 63... (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR Table 3 to Subpart Bbbbbb... - Applicability of General Provisions

Code of Federal Regulations, 2014 CFR

2014-07-01

... Maintain monitoring system in a manner consistent with good air pollution control practices Yes. § 63.8(c...) Maintenance records Recordkeeping of maintenance on air pollution control and monitoring equipment Yes. § 63... (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR 75.46 - Missing data substitution criteria.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Missing data substitution criteria. 75... (CONTINUED) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.46 Missing data substitution criteria. The owner or operator shall demonstrate that all missing data can be accounted for in a manner...

40 CFR 75.46 - Missing data substitution criteria.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Missing data substitution criteria. 75... (CONTINUED) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.46 Missing data substitution criteria. The owner or operator shall demonstrate that all missing data can be accounted for in a manner...

40 CFR 75.46 - Missing data substitution criteria.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Missing data substitution criteria. 75... (CONTINUED) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.46 Missing data substitution criteria. The owner or operator shall demonstrate that all missing data can be accounted for in a manner...

40 CFR 75.46 - Missing data substitution criteria.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Missing data substitution criteria. 75... (CONTINUED) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.46 Missing data substitution criteria. The owner or operator shall demonstrate that all missing data can be accounted for in a manner...

40 CFR 75.46 - Missing data substitution criteria.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Missing data substitution criteria. 75... (CONTINUED) CONTINUOUS EMISSION MONITORING Alternative Monitoring Systems § 75.46 Missing data substitution criteria. The owner or operator shall demonstrate that all missing data can be accounted for in a manner...

40 CFR 86.1237-85 - Dynamometer runs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Evaporative... or pushed onto the dynamometer; however, if driven, the period of engine operation between the end of... manner that it is not exposed to precipitation (e.g., rain or dew). (b) The following steps shall be...

Understanding the yield gap in wheat production

USDA-ARS?s Scientific Manuscript database

Wheat production around the globe is a staple of human nutrition needs and will continue to provide a major component of global food security. The increases in world population demand that we continue to increase wheat production in a sustainable manner. To achieve this goal requires that we underst...

24 CFR 330.15 - Participation requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... sponsored enterprises. (d) Integrity. The participant must conduct its business operations in accordance... manner, as determined by the Association. (Approved by the Office of Management and Budget under control...

Delivering biodefense continuing education to military medical providers by allowing a biodefense educational curriculum to unfold in practice.

PubMed

D'Alessandro, Donna M; D'Alessandro, Michael P

2007-12-01

A challenge today is how to deliver initial and continuing education on biodefense to military medical providers in a manner that can be integrated into their workflow and lifestyle. A summative evaluation of a prototypical biodefense digital library (BDL) and learning collaboratory was performed. The BDL posted daily links to biodefense news stories from January 2004 to December 2005. Four evaluations were completed, that is, content evaluation, curriculum comparison with a biodefense graduate program, usage evaluation, and impact factor analysis. News stories (N = 678) came from a broad range of authoritative national and international news sources (N = 178). News stories covered all of the categories in the required and elective formal biodefense graduate program courses. The BDL was consistently displayed on the first page of the top three Internet search engines, meaning that it was among the top 10 authoritative Internet sites on biodefense. Presenting biodefense news stories to busy military medical providers in an organized chronological fashion produces an unstructured biodefense educational curriculum that unfolds in practice and becomes an educational resource that is ultimately well regarded and may be efficient to use.

Flies dynamically anti-track, rather than ballistically escape, aversive odor during flight.

PubMed

Wasserman, Sara; Lu, Patrick; Aptekar, Jacob W; Frye, Mark A

2012-08-15

Tracking distant odor sources is crucial to foraging, courtship and reproductive success for many animals including fish, flies and birds. Upon encountering a chemical plume in flight, Drosophila melanogaster integrates the spatial intensity gradient and temporal fluctuations over the two antennae, while simultaneously reducing the amplitude and frequency of rapid steering maneuvers, stabilizing the flight vector. There are infinite escape vectors away from a noxious source, in contrast to a single best tracking vector towards an attractive source. Attractive and aversive odors are segregated into parallel neuronal pathways in flies; therefore, the behavioral algorithms for avoidance may be categorically different from tracking. Do flies plot random ballistic or otherwise variable escape vectors? Or do they instead make use of temporally dynamic mechanisms for continuously and directly avoiding noxious odors in a manner similar to tracking appetitive ones? We examine this question using a magnetic tether flight simulator that permits free yaw movements, such that flies can actively orient within spatially defined odor plumes. We show that in-flight aversive flight behavior shares all of the key features of attraction such that flies continuously 'anti-track' the noxious source.

Flies dynamically anti-track, rather than ballistically escape, aversive odor during flight

PubMed Central

Wasserman, Sara; Lu, Patrick; Aptekar, Jacob W.; Frye, Mark A.

2012-01-01

SUMMARY Tracking distant odor sources is crucial to foraging, courtship and reproductive success for many animals including fish, flies and birds. Upon encountering a chemical plume in flight, Drosophila melanogaster integrates the spatial intensity gradient and temporal fluctuations over the two antennae, while simultaneously reducing the amplitude and frequency of rapid steering maneuvers, stabilizing the flight vector. There are infinite escape vectors away from a noxious source, in contrast to a single best tracking vector towards an attractive source. Attractive and aversive odors are segregated into parallel neuronal pathways in flies; therefore, the behavioral algorithms for avoidance may be categorically different from tracking. Do flies plot random ballistic or otherwise variable escape vectors? Or do they instead make use of temporally dynamic mechanisms for continuously and directly avoiding noxious odors in a manner similar to tracking appetitive ones? We examine this question using a magnetic tether flight simulator that permits free yaw movements, such that flies can actively orient within spatially defined odor plumes. We show that in-flight aversive flight behavior shares all of the key features of attraction such that flies continuously ‘anti-track’ the noxious source. PMID:22837456

Cardiophobia: a paradigmatic behavioural model of heart-focused anxiety and non-anginal chest pain.

PubMed

Eifert, G H

1992-07-01

Cardiophobia is defined as an anxiety disorder of persons characterized by repeated complaints of chest pain, heart palpitations, and other somatic sensations accompanied by fears of having a heart attack and of dying. Persons with cardiophobia focus attention on their heart when experiencing stress and arousal, perceive its function in a phobic manner, and continue to believe that they suffer from an organic heart problem despite repeated negative medical tests. In order to reduce anxiety, they seek continuous reassurance, make excessive use of medical facilities, and avoid activities believed to elicit symptoms. The relationship of cardiophobia to illness phobia, health anxiety, and panic disorder is discussed. An integrative psychobiological model of cardiophobia is presented which includes previous learning conditions relating to experiences of separation and cardiac disease; deficient and inappropriate behavioural repertoires which constitute a psychological vulnerability for cardiophobic problems; negative life events, stressors, and conflicts in the person's present situation that trigger and contribute to the symptoms; current affective, cognitive, and behavioural symptoms and their stimulus properties; and genetic and acquired biological vulnerability factors. Finally, recommendations for the treatment of cardiophobia are derived from the model and areas of future research are outlined.

Identifying legal, ecological and governance obstacles and opportunities for adapting to climate change

USGS Publications Warehouse

Cosens, Barbara; Gunderson, Lance; Allen, Craig R.; Benson, Melinda H.

2014-01-01

Current governance of regional scale water management systems in the United States has not placed them on a path toward sustainability, as conflict and gridlock characterize the social arena and ecosystem services continue to erode. Changing climate may continue this trajectory, but it also provides a catalyst for renewal of ecosystems and a window of opportunity for change in institutions. Resilience provides a bridging concept that predicts that change in ecological and social systems is often dramatic, abrupt, and surprising. Adapting to the uncertainty of climate driven change must be done in a manner perceived as legitimate by the participants in a democratic society. Adaptation must begin with the current hierarchical and fragmented social-ecological system as a baseline from which new approaches must be applied. Achieving a level of integration between ecological concepts and governance requires a dialogue across multiple disciplines, including ecologists with expertise in ecological resilience, hydrologists and climate experts, with social scientists and legal scholars. Criteria and models that link ecological dynamics with policies in complex, multi-jurisdictional water basins with adaptive management and governance frameworks may move these social-ecological systems toward greater sustainability.

Curriculum reform and evolution: Innovative content and processes at one US medical school.

PubMed

Fischel, Janet E; Olvet, Doreen M; Iuli, Richard J; Lu, Wei-Hsin; Chandran, Latha

2018-03-11

Curriculum reform in medical schools continues to be an ever-present and challenging activity in medical education. This paper describes one school's experiences with specific curricular innovations that were developed or adapted and targeted to meet a clear set of curricular goals during the curriculum reform process. Those goals included: (a) promoting active learning and learner engagement; (b) establishing early professional identity; and (c) developing physician competencies in an integrated and contextual manner while allowing for individualized learning experiences for the millennial student. Six specific innovations championed by the school are described in detail. These included Themes in Medical Education, Translational Pillars, Stony Brook Teaching Families, Transition Courses, Educational Continuous Quality Improvement Processes, and our Career Advising Program. Development of the ideas and design of the innovations were done by faculty and student teams. We discuss successes and ongoing challenges with these innovations which are currently in the fourth year of implementation. Our curriculum reform has emphasized the iterative process of curriculum building. Based on our experience, we discuss general and practical guidelines for curriculum innovation in its three phases: setting the stage, implementation, and monitoring for the achievement of intended goals.

How We Use What We Learn in Math: An Integrative Account of the Development of Commutativity

ERIC Educational Resources Information Center

Haider, Hilde; Eichler, Alexandra; Hansen, Sonja; Vaterrodt, Bianca; Gaschler, Robert; Frensch, Peter A.

2014-01-01

One crucial issue in mathematics development is how children come to spontaneously apply arithmetical principles (e.g. commutativity). According to expertise research, well-integrated conceptual and procedural knowledge is required. Here, we report a method composed of two independent tasks that assessed in an unobtrusive manner the spontaneous…

Integrating Mathematical Modeling for Undergraduate Pre-Service Science Education Learning and Instruction in Middle School Classrooms

ERIC Educational Resources Information Center

Carrejo, David; Robertson, William H.

2011-01-01

Computer-based mathematical modeling in physics is a process of constructing models of concepts and the relationships between them in the scientific characteristics of work. In this manner, computer-based modeling integrates the interactions of natural phenomenon through the use of models, which provide structure for theories and a base for…

The Divide between Diversity Training and Diversity Education: Integrating Best Practices

ERIC Educational Resources Information Center

King, Eden B.; Gulick, Lisa M. V.; Avery, Derek R.

2010-01-01

The fields of diversity training and diversity education have developed in a disconnected manner. This divide ensures that each field advances slowly and with narrow focus. The authors argue here that the divide should be bridged with attention to the best practices that diversity training and diversity education offer. By integrating the best…

Assessment of Creativity in Arts and STEM Integrated Pedagogy by Pre-Service Elementary Teachers

ERIC Educational Resources Information Center

Tillman, Daniel A.; An, Song A.; Boren, Rachel L.

2015-01-01

In education, mathematics and science are often taught in a manner that lacks opportunities for students to engage in creativity, and the arts are allotted less time with fewer resources. This study focused on integrating STEM (science, technology, engineering, and mathematics) lessons with arts-themed activities to create interdisciplinary STEAM…

An Integrated Approach to Management Communication at the T. A. Pai Management Institute

ERIC Educational Resources Information Center

Gupta, Jaba Mukherjee

2005-01-01

Stand-alone communication courses are still the dominant model in both Indian and US schools. Communication courses are taught separately and not integrated into the main course curriculum in a formal manner by communication faculty working alongside with the rest of the faculty. Although this may over-generalize, it suggests the background…

ACCELERATION INTEGRATOR

DOEpatents

Pope, K.E.

1958-01-01

This patent relates to an improved acceleration integrator and more particularly to apparatus of this nature which is gyrostabilized. The device may be used to sense the attainment by an airborne vehicle of a predetermined velocitv or distance along a given vector path. In its broad aspects, the acceleration integrator utilizes a magnetized element rotatable driven by a synchronous motor and having a cylin drical flux gap and a restrained eddy- current drag cap deposed to move into the gap. The angular velocity imparted to the rotatable cap shaft is transmitted in a positive manner to the magnetized element through a servo feedback loop. The resultant angular velocity of tae cap is proportional to the acceleration of the housing in this manner and means may be used to measure the velocity and operate switches at a pre-set magnitude. To make the above-described dcvice sensitive to acceleration in only one direction the magnetized element forms the spinning inertia element of a free gyroscope, and the outer housing functions as a gimbal of a gyroscope.

Guidance Manual for Integrating Hazardous Material Control and Management into System Acquisition Programs

DTIC Science & Technology

1993-04-01

34 in the remainder of this "• IPS. Ensure that system safety, Section refer to the DoD format paragraph health hazards, and environmental for the...hazardous materials is controlled in the manner which protects human health and the environment at the least cost. Hazardous Material Control and Management...of hazardous materials is controlled in a manner which protects human health and the environment at the least cost. Hazardous Material Control and

Summary of the Science Performed Onboard the International Space Station within the United States Orbital Segment during Increments 16 and 17

NASA Technical Reports Server (NTRS)

Jules, Kenol; Istasse, Eric; Stenuit, Hilde; Murakami, Jeiji; Yoshizaki, Izumi; Johnson-Green, Perry

2008-01-01

With the launch of the STS-122 on February 7, 2008, which delivered the European Columbus science module and the upcoming STS-124 flight, which will deliver the Japanese Kibo science module in May 2008, the International Space Station will become truly International with Europe and Japan joining the United States of America and Russia to perform science on a continuous basis in a wide spectrum of science disciplines. The last science module, Kibo, of the United States Orbital Segment (USOS) will be mated to the station on time to celebrate its first decade in low Earth orbit in October 2008 (end of Increment 17), thus ushering in the second decade of the station with all the USOS science modules mated and performing science. The arrival of the Kibo science module will also mark continuous human presence on the station for eighty eight (88) months, and, with the addition of the ESA science module during the STS-122 flight, the USOS will be made up of four space agencies: CSA, ESA, JAXA and NASA, spanning three continents. With the additional partners coming onboard with different research needs, every effort is being made to coordinate science across the USOS segment in an integrated manner for the benefit of all parties. One of the objectives of this paper is to discuss the integrated manner in which science planning/replanning and prioritization during the execution phase of an increment is being done. The main focus, though, of this paper is to summarize and to discuss the science performed during Increments 16 and 17 (October 2007 to October 2008). The discussion will focus mainly on the primary objectives of each investigation and their associated hypotheses that were investigated during these two Increments. Also, preliminary science results will be discussed for each of the investigation as science results availability permit. Additionally, the paper will briefly touch on what the science complement for these two increments was and what was actually accomplished due to real time science implementation and constraints. Finally, the paper will briefly discuss the science research complements for the next three Increments: Increments 18 to 20, in order to preview how much science might be accomplished during these three upcoming Increments of the station next decade.

Brief Daily Periods of Unrestricted Vision Can Prevent Form-Deprivation Amblyopia

PubMed Central

Wensveen, Janice M.; Harwerth, Ronald S.; Hung, Li-Fang; Ramamirtham, Ramkumar; Kee, Chea-su; Smith, Earl L.

2006-01-01

PURPOSE To characterize how the mechanisms that produce unilateral form-deprivation amblyopia integrate the effects of normal and abnormal vision over time, the effects of brief daily periods of unrestricted vision on the spatial vision losses produced by monocular form deprivation were investigated in infant monkeys. METHODS Beginning at 3 weeks of age, unilateral form deprivation was initiated in 18 infant monkeys by securing a diffuser spectacle lens in front of one eye and a clear plano lens in front of the fellow eye. During the treatment period (18 weeks), three infants wore the diffusers continuously. For the other experimental infants, the diffusers were removed daily and replaced with clear, zero-powered lenses for 1 (n = 5), 2 (n = 6), or 4 (n = 4) hours. Four infants reared with binocular zero-powered lenses and four normally reared monkeys provided control data. RESULTS The degree of amblyopia varied significantly with the daily duration of unrestricted vision. Continuous form deprivation caused severe amblyopia. However, 1 hour of unrestricted vision reduced the degree of amblyopia by 65%, 2 hours reduced the deficits by 90%, and 4 hours preserved near-normal spatial contrast sensitivity. CONCLUSIONS The severely amblyogenic effects of form deprivation in infant primates are substantially reduced by relatively short daily periods of unrestricted vision. The manner in which the mechanisms responsible for amblyopia integrate the effects of normal and abnormal vision over time promotes normal visual development and has important implications for the management of human infants with conditions that potentially cause amblyopia. PMID:16723458

32 CFR 635.8 - General.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true General. 635.8 Section 635.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Release of Information § 635.8 General. (a) The policy of HQDA is to conduct activities in an open manner and...

26 CFR 1.861-7 - Sale of personal property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... particular manner for the primary purpose of tax avoidance, the foregoing rules will not be applied. In such...-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Tax Based on Income from Sources within Or Without the United States § 1.861-7 Sale...

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2013 CFR

2013-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2014 CFR

2014-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

Transportation planning and ITS : putting the pieces together

DOT National Transportation Integrated Search

1998-01-01

Intelligent Transportation Systems (ITS) include the application of computer, electronics, and communications technologies and management strategies -- in an integrated manner -- providing traveler information to increase the safety and efficiency of...

Engaging Non-Science Majors by Integrating Biology and the Liberal Arts

ERIC Educational Resources Information Center

Bozzone, Donna M.; Doyle, Mary Beth

2017-01-01

We describe a pair of fully integrated courses designed to teach biology to non-majors in a manner that connects authentically to the liberal arts. The co-taught courses were organized around the question: What does it mean to be human? Students investigated this question in the context of three topics: dis/ability, race, and sex and gender. In…

Hybrid Learning Environments: Merging Learning and Work Processes to Facilitate Knowledge Integration and Transitions. OECD Education Working Papers, No. 81

ERIC Educational Resources Information Center

Zitter, Ilya; Hoeve, Aimee

2012-01-01

This paper deals with the problematic nature of the transition between education and the workplace. A smooth transition between education and the workplace requires learners to develop an integrated knowledge base, but this is problematic as most educational programmes offer knowledge and experiences in a fragmented manner, scattered over a…

Taxometric and Factor Analytic Models of Anxiety Sensitivity: Integrating Approaches to Latent Structural Research

ERIC Educational Resources Information Center

Bernstein, Amit; Zvolensky, Michael J.; Norton, Peter J.; Schmidt, Norman B.; Taylor, Steven; Forsyth, John P.; Lewis, Sarah F.; Feldner, Matthew T.; Leen-Feldner, Ellen W.; Stewart, Sherry H.; Cox, Brian

2007-01-01

This study represents an effort to better understand the latent structure of anxiety sensitivity (AS), as indexed by the 16-item Anxiety Sensitivity Index (ASI; S. Reiss, R. A. Peterson, M. Gursky, & R. J. McNally, 1986), by using taxometric and factor-analytic approaches in an integrative manner. Taxometric analyses indicated that AS has a…

Integrating XQuery-Enabled SCORM XML Metadata Repositories into an RDF-Based E-Learning P2P Network

ERIC Educational Resources Information Center

Qu, Changtao; Nejdl, Wolfgang

2004-01-01

Edutella is an RDF-based E-Learning P2P network that is aimed to accommodate heterogeneous learning resource metadata repositories in a P2P manner and further facilitate the exchange of metadata between these repositories based on RDF. Whereas Edutella provides RDF metadata repositories with a quite natural integration approach, XML metadata…

Changing the Engineering Student Culture with Respect to Academic Integrity and Ethics.

PubMed

VanDeGrift, Tammy; Dillon, Heather; Camp, Loreal

2017-08-01

Engineers create airplanes, buildings, medical devices, and software, amongst many other things. Engineers abide by a professional code of ethics to uphold people's safety and the reputation of the profession. Likewise, students abide by a code of academic integrity while learning the knowledge and necessary skills to prepare them for the engineering and computing professions. This paper reports on studies designed to improve the engineering student culture with respect to academic integrity and ethics. To understand the existing culture at a university in the USA, a survey based on a national survey about cheating was administered to students. The incidences of self-reported cheating and incidences of not reporting others who cheat show the culture is similar to other institutions. Two interventions were designed and tested in an introduction to an engineering course: two case studies that students discussed in teams and the whole class, and a letter of recommendation assignment in which students wrote about themselves (character, strengths, examples of ethical decisions) three years into the future. Students were surveyed after the two interventions. Results show that first-year engineering students appreciate having a code of academic integrity and they want to earn their degree without cheating, yet less than half of the students would report on another cheating student. The letter of recommendation assignment had some impact on getting students to think about ethics, their character, and their actions. Future work in changing the student culture will continue in both a top-down (course interventions) and bottom-up (student-driven interventions) manner.

Enabling Agile Testing through Continuous Integration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stolberg, Sean E.

2009-08-24

A Continuous Integration system is often considered one of the key elements involved in supporting an agile software development and testing environment. As a traditional software tester transitioning to an agile development environment it became clear to me that I would need to put this essential infrastructure in place and promote improved development practices in order to make the transition to agile testing possible. This experience report discusses a continuous integration implementation I lead last year. The initial motivations for implementing continuous integration are discussed and a pre and post-assessment using Martin Fowler's "Practices of Continuous Integration" is provided alongmore » with the technical specifics of the implementation. Finally, I’ll wrap up with a retrospective of my experiences implementing and promoting continuous integration within the context of agile testing.« less

36 CFR 1008.6 - Assuring integrity of records.

Code of Federal Regulations, 2012 CFR

2012-07-01

... shall be maintained in a secure manner commensurate with the sensitivity of the information contained in the system of records. The Privacy Act Officer will periodically review these security measures to...

36 CFR 1008.6 - Assuring integrity of records.

Code of Federal Regulations, 2011 CFR

2011-07-01

... shall be maintained in a secure manner commensurate with the sensitivity of the information contained in the system of records. The Privacy Act Officer will periodically review these security measures to...

36 CFR 1008.6 - Assuring integrity of records.

Code of Federal Regulations, 2014 CFR

2014-07-01

... shall be maintained in a secure manner commensurate with the sensitivity of the information contained in the system of records. The Privacy Act Officer will periodically review these security measures to...

Summary of International Waste Management Programs (LLNL Input to SNL L3 MS: System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenberg, Harris R.; Blink, James A.; Halsey, William G.

2011-08-11

The Used Fuel Disposition Campaign (UFDC) within the Department of Energy’s Office of Nuclear Energy (DOE-NE) Fuel Cycle Technology (FCT) program has been tasked with investigating the disposal of the nation’s spent nuclear fuel (SNF) and high-level nuclear waste (HLW) for a range of potential waste forms and geologic environments. This Lessons Learned task is part of a multi-laboratory effort, with this LLNL report providing input to a Level 3 SNL milestone (System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW). The work package number is: FTLL11UF0328; the work package title is: Technical Bases / Lessons Learned;more » the milestone number is: M41UF032802; and the milestone title is: “LLNL Input to SNL L3 MS: System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW”. The system-wide integration effort will integrate all aspects of waste management and disposal, integrating the waste generators, interim storage, transportation, and ultimate disposal at a repository site. The review of international experience in these areas is required to support future studies that address all of these components in an integrated manner. Note that this report is a snapshot of nuclear power infrastructure and international waste management programs that is current as of August 2011, with one notable exception. No attempt has been made to discuss the currently evolving world-wide response to the tragic consequences of the earthquake and tsunami that devastated Japan on March 11, 2011, leaving more than 15,000 people dead and more than 8,000 people missing, and severely damaging the Fukushima Daiichi nuclear power complex. Continuing efforts in FY 2012 will update the data, and summarize it in an Excel spreadsheet for easy comparison and assist in the knowledge management of the study cases.« less

36 CFR § 1008.6 - Assuring integrity of records.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Privacy Act shall be maintained in a secure manner commensurate with the sensitivity of the information contained in the system of records. The Privacy Act Officer will periodically review these security measures...

Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling.

PubMed

Hatano, Atsushi; Matsumoto, Masaki; Nakayama, Keiichi I

2016-10-01

A key issue in the study of signal transduction is how multiple signaling pathways are systematically integrated into the cell. We have now performed multiple phosphoproteomics analyses focused on the dynamics of the T-cell receptor (TCR) signaling network and its subsystem mediated by the Ca 2+ signaling pathway. Integration of these phosphoproteomics data sets and extraction of components of the TCR signaling network dependent on Ca 2+ signaling showed unexpected phosphorylation kinetics for candidate substrates of the Ca 2+ -dependent phosphatase calcineurin (CN) during TCR stimulation. Detailed characterization of the TCR-induced phosphorylation of a novel CN substrate, Itpkb, showed that phosphorylation of this protein is regulated by both CN and the mitogen-activated protein kinase Erk in a competitive manner. Phosphorylation of additional CN substrates was also found to be regulated by Erk and CN in a similar manner. The combination of multiple phosphoproteomics approaches thus showed two major subsystems mediated by Erk and CN in the TCR signaling network, with these subsystems regulating the phosphorylation of a group of proteins in a competitive manner. © 2016 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

Observation of a continuous modulation in a shape-memory alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lashley, Jason C; Smith, James L; Mihaila, Bogdan

2008-01-01

Elastic neutron-scattering, inelastic x-ray scattering, specific-heat, and pressure-dependent electrical transport measurements have been made on single crystals of AuZn and Au{sub 0.52}Zn{sub 0.48}. Elastic neutron scattering detects new commensurate Bragg peaks (modulation) appearing at Q = (1.33,0.67,0) at temperatures corresponding to each sample's transition temperature (T{sub M} = 64 and 45 K, respectively). Although the new Bragg peaks appear in a discontinuous manner in the Au{sub 0.52}Zn{sub 0.48} sample, they appear in a continuous manner in AuZn. Surprising us, the temperature dependence of the AuZn Bragg peak intensity and the specific-heat jump near T{sub M} are in favorable accord withmore » a continuous transition. A fit to the pressure dependence of T{sub M} suggests the presence of a critical end point in the AuZn phase diagram located at T*{sub M} = 2.7 K and p* = 3.1 GPa.« less

A Phenomenological Investigation of Pharmacists' Experiences, Motivation, and Preferences in the Context of Continuing Pharmacy Education

ERIC Educational Resources Information Center

Ladymon, Laura Beth

2017-01-01

The purpose of this phenomenological study was to describe select Tennessee pharmacists' experiences, motivation, and preferences in the context of continuing pharmacy education (CPE). The pharmacists' experiences, motivation, and preferences related to CPE were generally defined as participating in CPE programming in a manner that meets the needs…

26 CFR 1.6655(e)-1 - Time and manner for making election under the Omnibus Budget Reconciliation Act of 1993.

Code of Federal Regulations, 2010 CFR

2010-04-01

... REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Additions to... to Use Different Annualization Periods for Corporate Estimated Tax, must be filed by the 15th day of... Internal Revenue Service Center where the corporation files its income tax return. (c) Revocability of...

7 CFR 1780.75 - Contract provisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS Planning, Designing, Bidding, Contracting... including the manner by which it will be effected and the basis for settlement. In addition, such contracts...

Application of the malaria management model to the analysis of costs and benefits of DDT versus non-DDT malaria control.

PubMed

Pedercini, Matteo; Movilla Blanco, Santiago; Kopainsky, Birgit

2011-01-01

DDT is considered to be the most cost-effective insecticide for combating malaria. However, it is also the most environmentally persistent and can pose risks to human health when sprayed indoors. Therefore, the use of DDT for vector control remains controversial. In this paper we develop a computer-based simulation model to assess some of the costs and benefits of the continued use of DDT for Indoor Residual Spraying (IRS) versus its rapid phase out. We apply the prototype model to the aggregated sub Saharan African region. For putting the question about the continued use of DDT for IRS versus its rapid phase out into perspective we calculate the same costs and benefits for alternative combinations of integrated vector management interventions. Our simulation results confirm that the current mix of integrated vector management interventions with DDT as the main insecticide is cheaper than the same mix with alternative insecticides when only direct costs are considered. However, combinations with a stronger focus on insecticide-treated bed nets and environmental management show higher levels of cost-effectiveness than interventions with a focus on IRS. Thus, this focus would also allow phasing out DDT in a cost-effective manner. Although a rapid phase out of DDT for IRS is the most expensive of the tested intervention combinations it can have important economic benefits in addition to health and environmental impacts that are difficult to assess in monetary terms. Those economic benefits captured by the model include the avoided risk of losses in agricultural exports. The prototype simulation model illustrates how a computer-based scenario analysis tool can inform debates on malaria control policies in general and on the continued use of DDT for IRS versus its rapid phase out in specific. Simulation models create systematic mechanisms for analyzing alternative interventions and making informed trade offs.

Application of the Malaria Management Model to the Analysis of Costs and Benefits of DDT versus Non-DDT Malaria Control

PubMed Central

Pedercini, Matteo; Movilla Blanco, Santiago; Kopainsky, Birgit

2011-01-01

Introduction DDT is considered to be the most cost-effective insecticide for combating malaria. However, it is also the most environmentally persistent and can pose risks to human health when sprayed indoors. Therefore, the use of DDT for vector control remains controversial. Methods In this paper we develop a computer-based simulation model to assess some of the costs and benefits of the continued use of DDT for Indoor Residual Spraying (IRS) versus its rapid phase out. We apply the prototype model to the aggregated sub Saharan African region. For putting the question about the continued use of DDT for IRS versus its rapid phase out into perspective we calculate the same costs and benefits for alternative combinations of integrated vector management interventions. Results Our simulation results confirm that the current mix of integrated vector management interventions with DDT as the main insecticide is cheaper than the same mix with alternative insecticides when only direct costs are considered. However, combinations with a stronger focus on insecticide-treated bed nets and environmental management show higher levels of cost-effectiveness than interventions with a focus on IRS. Thus, this focus would also allow phasing out DDT in a cost-effective manner. Although a rapid phase out of DDT for IRS is the most expensive of the tested intervention combinations it can have important economic benefits in addition to health and environmental impacts that are difficult to assess in monetary terms. Those economic benefits captured by the model include the avoided risk of losses in agricultural exports. Conclusions The prototype simulation model illustrates how a computer-based scenario analysis tool can inform debates on malaria control policies in general and on the continued use of DDT for IRS versus its rapid phase out in specific. Simulation models create systematic mechanisms for analyzing alternative interventions and making informed trade offs. PMID:22140467

Matefin/SUN-1 Phosphorylation Is Part of a Surveillance Mechanism to Coordinate Chromosome Synapsis and Recombination with Meiotic Progression and Chromosome Movement

PubMed Central

Woglar, Alexander; Daryabeigi, Anahita; Adamo, Adele; Habacher, Cornelia; Machacek, Thomas; La Volpe, Adriana; Jantsch, Verena

2013-01-01

Faithful chromosome segregation during meiosis I depends on the establishment of a crossover between homologous chromosomes. This requires induction of DNA double-strand breaks (DSBs), alignment of homologs, homolog association by synapsis, and repair of DSBs via homologous recombination. The success of these events requires coordination between chromosomal events and meiotic progression. The conserved SUN/KASH nuclear envelope bridge establishes transient linkages between chromosome ends and cytoskeletal forces during meiosis. In Caenorhabditis elegans, this bridge is essential for bringing homologs together and preventing nonhomologous synapsis. Chromosome movement takes place during synapsis and recombination. Concomitant with the onset of chromosome movement, SUN-1 clusters at chromosome ends associated with the nuclear envelope, and it is phosphorylated in a chk-2- and plk-2-dependent manner. Identification of all SUN-1 phosphomodifications at its nuclear N terminus allowed us to address their role in prophase I. Failures in recombination and synapsis led to persistent phosphorylations, which are required to elicit a delay in progression. Unfinished meiotic tasks elicited sustained recruitment of PLK-2 to chromosome ends in a SUN-1 phosphorylation–dependent manner that is required for continued chromosome movement and characteristic of a zygotene arrest. Furthermore, SUN-1 phosphorylation supported efficient synapsis. We propose that signals emanating from a failure to successfully finish meiotic tasks are integrated at the nuclear periphery to regulate chromosome end–led movement and meiotic progression. The single unsynapsed X chromosome in male meiosis is precluded from inducing a progression delay, and we found it was devoid of a population of phosphorylated SUN-1. This suggests that SUN-1 phosphorylation is critical to delaying meiosis in response to perturbed synapsis. SUN-1 may be an integral part of a checkpoint system to monitor establishment of the obligate crossover, inducible only in leptotene/zygotene. Unrepaired DSBs and unsynapsed chromosomes maintain this checkpoint, but a crossover intermediate is necessary to shut it down. PMID:23505384

MicroRNA networks in mouse lung organogenesis.

PubMed

Dong, Jie; Jiang, Guoqian; Asmann, Yan W; Tomaszek, Sandra; Jen, Jin; Kislinger, Thomas; Wigle, Dennis A

2010-05-26

MicroRNAs (miRNAs) are known to be important regulators of both organ development and tumorigenesis. MiRNA networks and their regulation of messenger RNA (mRNA) translation and protein expression in specific biological processes are poorly understood. We explored the dynamic regulation of miRNAs in mouse lung organogenesis. Comprehensive miRNA and mRNA profiling was performed encompassing all recognized stages of lung development beginning at embryonic day 12 and continuing to adulthood. We analyzed the expression patterns of dynamically regulated miRNAs and mRNAs using a number of statistical and computational approaches, and in an integrated manner with protein levels from an existing mass-spectrometry derived protein database for lung development. In total, 117 statistically significant miRNAs were dynamically regulated during mouse lung organogenesis and clustered into distinct temporal expression patterns. 11,220 mRNA probes were also shown to be dynamically regulated and clustered into distinct temporal expression patterns, with 3 major patterns accounting for 75% of all probes. 3,067 direct miRNA-mRNA correlation pairs were identified involving 37 miRNAs. Two defined correlation patterns were observed upon integration with protein data: 1) increased levels of specific miRNAs directly correlating with downregulation of predicted mRNA targets; and 2) increased levels of specific miRNAs directly correlating with downregulation of translated target proteins without detectable changes in mRNA levels. Of 1345 proteins analyzed, 55% appeared to be regulated in this manner with a direct correlation between miRNA and protein level, but without detectable change in mRNA levels. Systematic analysis of microRNA, mRNA, and protein levels over the time course of lung organogenesis demonstrates dynamic regulation and reveals 2 distinct patterns of miRNA-mRNA interaction. The translation of target proteins affected by miRNAs independent of changes in mRNA level appears to be a prominent mechanism of developmental regulation in lung organogenesis.

Intelligent Transportation Systems (ITS) plan for Canada : en route to intelligent mobility

DOT National Transportation Integrated Search

1999-11-01

Intelligent Transportation Systems (ITS) include the application of advanced information processing, communications, sensor and control technologies and management strategies in an integrated manner to improve the functioning of the transportation sy...

Creating a provider network: fact, fantasy, and future.

PubMed

Meeks, J S

1997-09-01

Integrated delivery systems should consider multiple options through which to affiliate, with primary care physicians and advanced practice nurses. Caution should be employed to assure that system alignment occurs in an efficient, effective manner.

Prolong Your Roof's Performance: Roof Asset Management.

ERIC Educational Resources Information Center

Teitsma, Jerry

2001-01-01

Discusses the roof asset management process for maintaining a roof system's integrity and value in a cost-effective manner. Included is a breakdown of roofing surface characteristics for multiply and single ply roofing systems. (GR)

Electrosensory Midbrain Neurons Display Feature Invariant Responses to Natural Communication Stimuli.

PubMed

Aumentado-Armstrong, Tristan; Metzen, Michael G; Sproule, Michael K J; Chacron, Maurice J

2015-10-01

Neurons that respond selectively but in an invariant manner to a given feature of natural stimuli have been observed across species and systems. Such responses emerge in higher brain areas, thereby suggesting that they occur by integrating afferent input. However, the mechanisms by which such integration occurs are poorly understood. Here we show that midbrain electrosensory neurons can respond selectively and in an invariant manner to heterogeneity in behaviorally relevant stimulus waveforms. Such invariant responses were not seen in hindbrain electrosensory neurons providing afferent input to these midbrain neurons, suggesting that response invariance results from nonlinear integration of such input. To test this hypothesis, we built a model based on the Hodgkin-Huxley formalism that received realistic afferent input. We found that multiple combinations of parameter values could give rise to invariant responses matching those seen experimentally. Our model thus shows that there are multiple solutions towards achieving invariant responses and reveals how subthreshold membrane conductances help promote robust and invariant firing in response to heterogeneous stimulus waveforms associated with behaviorally relevant stimuli. We discuss the implications of our findings for the electrosensory and other systems.

Promising Perceptions, Divergent Practices and Barriers to Integrated Malaria Prevention in Wakiso District, Uganda: A Mixed Methods Study

PubMed Central

Musoke, David; Miiro, George; Karani, George; Morris, Keith; Kasasa, Simon; Ndejjo, Rawlance; Nakiyingi-Miiro, Jessica; Guwatudde, David; Musoke, Miph Boses

2015-01-01

Background The World Health Organization recommends use of multiple approaches to control malaria. The integrated approach to malaria prevention advocates the use of several malaria prevention methods in a holistic manner. This study assessed perceptions and practices on integrated malaria prevention in Wakiso district, Uganda. Methods A clustered cross-sectional survey was conducted among 727 households from 29 villages using both quantitative and qualitative methods. Assessment was done on awareness of various malaria prevention methods, potential for use of the methods in a holistic manner, and reasons for dislike of certain methods. Households were classified as using integrated malaria prevention if they used at least two methods. Logistic regression was used to test for factors associated with the use of integrated malaria prevention while adjusting for clustering within villages. Results Participants knew of the various malaria prevention methods in the integrated approach including use of insecticide treated nets (97.5%), removing mosquito breeding sites (89.1%), clearing overgrown vegetation near houses (97.9%), and closing windows and doors early in the evenings (96.4%). If trained, most participants (68.6%) would use all the suggested malaria prevention methods of the integrated approach. Among those who would not use all methods, the main reasons given were there being too many (70.2%) and cost (32.0%). Only 33.0% households were using the integrated approach to prevent malaria. Use of integrated malaria prevention by households was associated with reading newspapers (AOR 0.34; 95% CI 0.22 –0.53) and ownership of a motorcycle/car (AOR 1.75; 95% CI 1.03 – 2.98). Conclusion Although knowledge of malaria prevention methods was high and perceptions on the integrated approach promising, practices on integrated malaria prevention was relatively low. The use of the integrated approach can be improved by promoting use of multiple malaria prevention methods through various communication channels such as mass media. PMID:25837978

7 CFR 1212.106 - Referendum report.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Administrator a report on the results of the referendum, the manner in which it was conducted, the extent and... results. ...

40 CFR 92.1006 - Refueling requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Requirements Applicable to... designed in such a manner so as not to render inoperative or reduce the effectiveness of the controls on...

Triboelectric Nanogenerator Enabled Body Sensor Network for Self-Powered Human Heart-Rate Monitoring.

PubMed

Lin, Zhiming; Chen, Jun; Li, Xiaoshi; Zhou, Zhihao; Meng, Keyu; Wei, Wei; Yang, Jin; Wang, Zhong Lin

2017-09-26

Heart-rate monitoring plays a critical role in personal healthcare management. A low-cost, noninvasive, and user-friendly heart-rate monitoring system is highly desirable. Here, a self-powered wireless body sensor network (BSN) system is developed for heart-rate monitoring via integration of a downy-structure-based triboelectric nanogenerator (D-TENG), a power management circuit, a heart-rate sensor, a signal processing unit, and Bluetooth module for wireless data transmission. By converting the inertia energy of human walking into electric power, a maximum power of 2.28 mW with total conversion efficiency of 57.9% was delivered at low operation frequency, which is capable of immediately and sustainably driving the highly integrated BSN system. The acquired heart-rate signal by the sensor would be processed in the signal process circuit, sent to an external device via the Bluetooth module, and displayed on a personal cell phone in a real-time manner. Moreover, by combining a TENG-based generator and a TENG-based sensor, an all-TENG-based wireless BSN system was developed, realizing continuous and self-powered heart-rate monitoring. This work presents a potential method for personal heart-rate monitoring, featured as being self-powered, cost-effective, noninvasive, and user-friendly.

Integrating Spaceflight Human System Risk Research

NASA Technical Reports Server (NTRS)

Mindock, Jennifer; Lumpkins, Sarah; Anton, Wilma; Havenhill, Maria; Shelhamer, Mark; Canga, Michael

2016-01-01

NASA is working to increase the likelihood of human health and performance success during exploration missions as well as to maintain the subsequent long-term health of the crew. To manage the risks in achieving these goals, a system modelled after a Continuous Risk Management framework is in place. "Human System Risks" (Risks) have been identified, and approximately 30 are being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Inter-disciplinary ties between the research efforts supporting each Risk have been identified; however, efforts to identify and benefit from these connections have been mostly ad hoc. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioural, vehicle, and organizational aspects of exploration missions must be integrated across Risks and disciplines. This paper discusses how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information enables identification and visualization of connections between Risks and research efforts in a systematic and standardized manner. This paper also discusses the applications of the visualizations and insights into research planning, solicitation, and decision-making processes.

Perspective: Fabrication of integrated organ-on-a-chip via bioprinting.

PubMed

Yang, Qingzhen; Lian, Qin; Xu, Feng

2017-05-01

Organ-on-a-chip has emerged as a powerful platform with widespread applications in biomedical engineering, such as pathology studies and drug screening. However, the fabrication of organ-on-a-chip is still a challenging task due to its complexity. For an integrated organ-on-a-chip, it may contain four key elements, i.e., a microfluidic chip, live cells/microtissues that are cultured in this chip, components for stimulus loading to mature the microtissues, and sensors for results readout. Recently, bioprinting has been used for fabricating organ-on-a-chip as it enables the printing of multiple materials, including biocompatible materials and even live cells in a programmable manner with a high spatial resolution. Besides, all four elements for organ-on-a-chip could be printed in a single continuous procedure on one printer; in other words, the fabrication process is assembly free. In this paper, we discuss the recent advances of organ-on-a-chip fabrication by bioprinting. Light is shed on the printing strategies, materials, and biocompatibility. In addition, some specific bioprinted organs-on-chips are analyzed in detail. Because the bioprinted organ-on-a-chip is still in its early stage, significant efforts are still needed. Thus, the challenges presented together with possible solutions and future trends are also discussed.

IAServ: an intelligent home care web services platform in a cloud for aging-in-place.

PubMed

Su, Chuan-Jun; Chiang, Chang-Yu

2013-11-12

As the elderly population has been rapidly expanding and the core tax-paying population has been shrinking, the need for adequate elderly health and housing services continues to grow while the resources to provide such services are becoming increasingly scarce. Thus, increasing the efficiency of the delivery of healthcare services through the use of modern technology is a pressing issue. The seamless integration of such enabling technologies as ontology, intelligent agents, web services, and cloud computing is transforming healthcare from hospital-based treatments to home-based self-care and preventive care. A ubiquitous healthcare platform based on this technological integration, which synergizes service providers with patients' needs to be developed to provide personalized healthcare services at the right time, in the right place, and the right manner. This paper presents the development and overall architecture of IAServ (the Intelligent Aging-in-place Home care Web Services Platform) to provide personalized healthcare service ubiquitously in a cloud computing setting to support the most desirable and cost-efficient method of care for the aged-aging in place. The IAServ is expected to offer intelligent, pervasive, accurate and contextually-aware personal care services. Architecturally the implemented IAServ leverages web services and cloud computing to provide economic, scalable, and robust healthcare services over the Internet.

An Assessment of CFD Effectiveness for Vortex Flow Simulation to Meet Preliminary Design Needs

NASA Technical Reports Server (NTRS)

Raj, P.; Ghaffari, F.; Finley, D. B.

2003-01-01

The low-speed flight and transonic maneuvering characteristics of combat air vehicles designed for efficient supersonic flight are significantly affected by the presence of free vortices. At moderate-to-high angles of attack, the flow invariably separates from the leading edges of the swept slender wings, as well as from the forebodies of the air vehicles, and rolls up to form free vortices. The design of military vehicles is heavily driven by the need to simultaneously improve performance and affordability.1 In order to meet this need, increasing emphasis is being placed on using Modeling & Simulation environments employing the Integrated Product & Process Development (IPPD) concept. The primary focus is on expeditiously providing design teams with high-fidelity data needed to make more informed decisions in the preliminary design stage. Extensive aerodynamic data are needed to support combat air vehicle design. Force and moment data are used to evaluate performance and handling qualities; surface pressures provide inputs for structural design; and flow-field data facilitate system integration. Continuing advances in computational fluid dynamics (CFD) provide an attractive means of generating the desired data in a manner that is responsive to the needs of the preliminary design efforts. The responsiveness is readily characterized as timely delivery of quality data at low cost.

Integrating spaceflight human system risk research

NASA Astrophysics Data System (ADS)

Mindock, Jennifer; Lumpkins, Sarah; Anton, Wilma; Havenhill, Maria; Shelhamer, Mark; Canga, Michael

2017-10-01

NASA is working to increase the likelihood of exploration mission success and to maintain crew health, both during exploration missions and long term after return to Earth. To manage the risks in achieving these goals, a system modelled after a Continuous Risk Management framework is in place. ;Human System Risks; (Risks) have been identified, and 32 are currently being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Inter-disciplinary ties between the research efforts supporting each Risk have been identified; however, efforts to identify and benefit from these connections have been mostly ad hoc. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioural, vehicle, and organizational aspects of exploration missions must be integrated across Risks and disciplines. This paper discusses how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information enables identification and visualization of connections between Risks and research efforts in a systematic and standardized manner. This paper also discusses the applications of the visualizations and insights into research planning, solicitation, and decision-making processes.

IAServ: An Intelligent Home Care Web Services Platform in a Cloud for Aging-in-Place

PubMed Central

Su, Chuan-Jun; Chiang, Chang-Yu

2013-01-01

As the elderly population has been rapidly expanding and the core tax-paying population has been shrinking, the need for adequate elderly health and housing services continues to grow while the resources to provide such services are becoming increasingly scarce. Thus, increasing the efficiency of the delivery of healthcare services through the use of modern technology is a pressing issue. The seamless integration of such enabling technologies as ontology, intelligent agents, web services, and cloud computing is transforming healthcare from hospital-based treatments to home-based self-care and preventive care. A ubiquitous healthcare platform based on this technological integration, which synergizes service providers with patients’ needs to be developed to provide personalized healthcare services at the right time, in the right place, and the right manner. This paper presents the development and overall architecture of IAServ (the Intelligent Aging-in-place Home care Web Services Platform) to provide personalized healthcare service ubiquitously in a cloud computing setting to support the most desirable and cost-efficient method of care for the aged-aging in place. The IAServ is expected to offer intelligent, pervasive, accurate and contextually-aware personal care services. Architecturally the implemented IAServ leverages web services and cloud computing to provide economic, scalable, and robust healthcare services over the Internet. PMID:24225647

Seismic field measurements in Kylylahti, Finland, in support of the further development of geophysical seismic techniques for CTBT On-site Inspections

NASA Astrophysics Data System (ADS)

Labak, Peter; Lindblom, Pasi; Malich, Gregor

2017-04-01

The Integrated Field Exercise of 2014 (IFE14) was a field event held in the Hashemite Kingdom of Jordan (with concurrent activities in Austria) during which the operational and technical capabilities of a Comprehensive Test Ban Treaty's (CTBT) on-site inspection (OSI) were tested in integrated manner. Many of the inspection techniques permitted by the CTBT were applied during IFE14 including a range of geophysical techniques, however, one of the techniques foreseen by the CTBT but not yet developed is resonance seismometry. During August and September 2016, seismic field measurements have been conducted in the region of Kylylahti, Finland, in support of the further development of geophysical seismic techniques for OSIs. 45 seismic stations were used to continuously acquire seismic signals. During that period, data from local, regional and teleseismic natural events and man-made events were acquired, including from a devastating earthquake in Italy and the nuclear explosion announced by the Democratic People's Republic of Korea on 9 September 2016. Also, data were acquired following the small-scale use of man-made chemical explosives in the area and of vibratory sources. This presentation will show examples from the data set and will discuss its use for the development of resonance seimometry for OSIs.

A theoretical framework to support research of health service innovation.

PubMed

Fox, Amanda; Gardner, Glenn; Osborne, Sonya

2015-02-01

Health service managers and policy makers are increasingly concerned about the sustainability of innovations implemented in health care settings. The increasing demand on health services requires that innovations are both effective and sustainable; however, research in this field is limited, with multiple disciplines, approaches and paradigms influencing the field. These variations prevent a cohesive approach, and therefore the accumulation of research findings, in the development of a body of knowledge. The purpose of this paper is to provide a thorough examination of the research findings and provide an appropriate theoretical framework to examine sustainability of health service innovation. This paper presents an integrative review of the literature available in relation to sustainability of health service innovation and provides the development of a theoretical framework based on integration and synthesis of the literature. A theoretical framework serves to guide research, determine variables, influence data analysis and is central to the quest for ongoing knowledge development. This research outlines the sustainability of innovation framework; a theoretical framework suitable for examining the sustainability of health service innovation. If left unaddressed, health services research will continue in an ad hoc manner, preventing full utilisation of outcomes, recommendations and knowledge for effective provision of health services. The sustainability of innovation theoretical framework provides an operational basis upon which reliable future research can be conducted.

Psychotherapy integration under scrutiny: investigating the impact of integrating emotion-focused components into a CBT-based approach: a study protocol of a randomized controlled trial.

PubMed

Babl, Anna; Grosse Holtforth, Martin; Heer, Sara; Lin, Mu; Stähli, Annabarbara; Holstein, Dominique; Belz, Martina; Egenolf, Yvonne; Frischknecht, Eveline; Ramseyer, Fabian; Regli, Daniel; Schmied, Emma; Flückiger, Christoph; Brodbeck, Jeannette; Berger, Thomas; Caspar, Franz

2016-11-24

This currently recruiting randomized controlled trial investigates the effects of integrating components of Emotion-Focused Therapy (EFT) into Psychological Therapy (PT), an integrative form of cognitive-behavioral therapy in a manner that is directly mirroring common integrative practice in the sense of assimilative integration. Aims of the study are to understand how both, an existing therapy approach as well as the elements to be integrated, are affected by the integration and to clarify the role of emotional processing as a mediator of therapy outcome. A total of 130 adults with a diagnosed unipolar depressive, anxiety or adjustment disorder (seeking treatment at a psychotherapy outpatient clinic) are randomized to either treatment as usual (PT) with integrated emotion-focused components (TAU + EFT) or PT (TAU). Primary outcome variables are psychopathology and symptom severity at the end of therapy and at follow up; secondary outcome variables are interpersonal problems, psychological wellbeing, quality of life, attainment of individual therapy goals, and emotional competency. Furthermore, process variables such as the quality of the therapeutic relationship are studied as well as aptitude-treatment interactions. Variables are assessed at baseline, after 8 and 16 sessions, at the end of therapy, after 25 ± 3 sessions, and at 6, 12 and 36 month follow-up. Underlying mechanisms of change are investigated. Statistical analyses will be conducted using the appropriate multilevel approaches, mainly two-level regression and growth analysis. The results of this study will indicate whether the integration of emotion-focused elements into treatment as usual increases the effectiveness of Psychological Therapy. If advantages are found, which may be limited to particular variables or subgroups of patients, recommendations for a systematic integration, and caveats if also disadvantages are detected, can be formulated. On a more abstract level, a cognitive behavioral (represented by PT) and humanistic/experiential (represented by EFT) approach will be integrated. It must be emphasized that mimicking common practice in the development and continued education of psychotherapists, EFT is not integrated as a whole, but only elements of EFT that are considered particularly important, and can be trained in an 8-day training plus supervision of therapies. ClinicalTrials.gov, NCT02822443 , 22 June 2016, retrospectively registered.

Translating research into clinical practice: integrating robotics into neurorehabilitation for stroke survivors.

PubMed

Backus, Deborah; Winchester, Patricia; Tefertiller, Candace

2010-01-01

Technological advances continue to infuse the field of neurorehabilitation with both excitement and apprehension. A challenge for clinicians is to determine which of the growing number of devices or interventions available should be incorporated into their clinical practice, and when and with whom they should be offered, in order to best assist their patients in attaining the highest level of function and quality of life. Robotics is one area of technology that has seen robust growth in rehabilitation applications, so much so that the presence of robotic devices in rehabilitation centers has become an expectation among patients, their caregivers, and therapists. Although rehabilitation robotic devices afford the opportunity to provide high doses of repetitive movement in a reliable and controllable manner, the role they play in the continuum of clinical care remains uncertain. The focus of this article is on translating the empirical evidence related to the application of rehabilitation robotics for improving lower limb and walking function in a manner that the clinician, or any stakeholder, will be able to incorporate relevant findings into clinical practice. A process is outlined and applied to a recent review of the literature related to the use of robotics for the treatment of lower limb and walking function in persons with stroke. This process provides the reader with a tool that can be applied to the translation and implementation of evidence related to any intervention for any client with neurological injury or disease.

49 CFR 511.76 - Qualifications and standards of conduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... appearing in proceedings before it to act with integrity, with respect, and in an ethical manner. Business..., refusal to adhere to reasonable standards of orderly and ethical conduct, failure to act in good faith, or...

Conjunctive Coding of Complex Object Features

PubMed Central

Erez, Jonathan; Cusack, Rhodri; Kendall, William; Barense, Morgan D.

2016-01-01

Critical to perceiving an object is the ability to bind its constituent features into a cohesive representation, yet the manner by which the visual system integrates object features to yield a unified percept remains unknown. Here, we present a novel application of multivoxel pattern analysis of neuroimaging data that allows a direct investigation of whether neural representations integrate object features into a whole that is different from the sum of its parts. We found that patterns of activity throughout the ventral visual stream (VVS), extending anteriorly into the perirhinal cortex (PRC), discriminated between the same features combined into different objects. Despite this sensitivity to the unique conjunctions of features comprising objects, activity in regions of the VVS, again extending into the PRC, was invariant to the viewpoints from which the conjunctions were presented. These results suggest that the manner in which our visual system processes complex objects depends on the explicit coding of the conjunctions of features comprising them. PMID:25921583

Face familiarity promotes stable identity recognition: exploring face perception using serial dependence

PubMed Central

Kok, Rebecca; Van der Burg, Erik; Rhodes, Gillian; Alais, David

2017-01-01

Studies suggest that familiar faces are processed in a manner distinct from unfamiliar faces and that familiarity with a face confers an advantage in identity recognition. Our visual system seems to capitalize on experience to build stable face representations that are impervious to variation in retinal input that may occur due to changes in lighting, viewpoint, viewing distance, eye movements, etc. Emerging evidence also suggests that our visual system maintains a continuous perception of a face's identity from one moment to the next despite the retinal input variations through serial dependence. This study investigates whether interactions occur between face familiarity and serial dependence. In two experiments, participants used a continuous scale to rate attractiveness of unfamiliar and familiar faces (either experimentally learned or famous) presented in rapid sequences. Both experiments revealed robust inter-trial effects in which attractiveness ratings for a given face depended on the preceding face's attractiveness. This inter-trial attractiveness effect was most pronounced for unfamiliar faces. Indeed, when participants were familiar with a given face, attractiveness ratings showed significantly less serial dependence. These results represent the first evidence that familiar faces can resist the temporal integration seen in sequential dependencies and highlight the importance of familiarity to visual cognition. PMID:28405355

Tanks Focus Area annual report FY2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2000-12-01

The U.S. Department of Energy (DOE) continues to face a major radioactive waste tank remediation effort with tanks containing hazardous and radioactive waste resulting from the production of nuclear materials. With some 90 million gallons of waste in the form of solid, sludge, liquid, and gas stored in 287 tanks across the DOE complex, containing approximately 650 million curies, radioactive waste storage tank remediation is the nation's highest cleanup priority. Differing waste types and unique technical issues require specialized science and technology to achieve tank cleanup in an environmentally acceptable manner. Some of the waste has been stored for overmore » 50 years in tanks that have exceeded their design lives. The challenge is to characterize and maintain these contents in a safe condition and continue to remediate and close each tank to minimize the risks of waste migration and exposure to workers, the public, and the environment. In 1994, the DOE's Office of Environmental Management (EM) created a group of integrated, multiorganizational teams focusing on specific areas of the EM cleanup mission. These teams have evolved into five focus areas managed within EM's Office of Science and Technology (OST): Tanks Focus Area (TFA); Deactivation and Decommissioning Focus Area; Nuclear Materials Focus Area; Subsurface Contaminants Focus Area; and Transuranic and Mixed Waste Focus Area.« less

[Synthesis of hollow titania microspheres by using microfluidic droplet-template].

PubMed

Ma, Jingyun; Jiang, Lei; Qin, Jianhu

2011-09-01

Droplet-based microfluidics is of great interest due to its particular characteristics compared with the conventional methods, such as reduced reagent consumption, rapid mixing, high-throughput, shape controlled, etc. A novel method using microfluidic droplet as soft template for the synthesis of hollow titania microspheres was developed. A typical polydimethylsiloxane (PDMS) microfluidic device containing "flow-focusing" geometry was used to generate water/oil (W/O) droplet. The mechanism for the hollow structure formation was based on the interfacial hydrolysis reaction between the continuous phase containing titanium butoxide precursor and the dispersed containing water. The continuous phase mixed with butanol was added in the downstream of the channel after the hydrolysis reaction. This step was used for drawing the water out of the microgels for further hydrolysis. The microgels obtained through a glass pipe integrated were washed, dried under vacuum and calcined after aging for a certain time. The fluorescence and scanning electron microscope (SEM) image of the microspheres indicated the hollow structure and the thickness of the shell. In addition, these microspheres with thin shell (about 2 microm) were apt to rupture and collapse. Droplet-based microfluidic offered a gentle and size-controllable manner to moderate this problem. Moreover, it has potential applications in photocatalysis combined with some modification realized on the chip simultaneously.

Survey of Federal, National, and International standards applicable to the NASA applications data services

NASA Technical Reports Server (NTRS)

Kuch, T.; Sakamoto, R.

1981-01-01

An applications data service (ADS) was developed to meet the challenges in the data access and integration. The ADS provides a common service to locate and access applications data electronically and integrate the cross correlative data sets required by multiple users. Its catalog and network services increase data visibility as well as provide the data in a more rapid manner and a usable form.

Monolithic Microwave Integrated Circuit (MMIC) Phased Array Demonstrated With ACTS

NASA Technical Reports Server (NTRS)

1996-01-01

Monolithic Microwave Integrated Circuit (MMIC) arrays developed by the NASA Lewis Research Center and the Air Force Rome Laboratory were demonstrated in aeronautical terminals and in mobile or fixed Earth terminals linked with NASA's Advanced Communications Technology Satellite (ACTS). Four K/Ka-band experimental arrays were demonstrated between May 1994 and May 1995. Each array had GaAs MMIC devices at each radiating element for electronic beam steering and distributed power amplification. The 30-GHz transmit array used in uplinks to ACTS was developed by Lewis and Texas Instruments. The three 20-GHz receive arrays used in downlinks from ACTS were developed in cooperation with the Air Force Rome Laboratory, taking advantage of existing Air Force integrated-circuit, active-phased-array development contracts with the Boeing Company and Lockheed Martin Corporation. Four demonstrations, each related to an application of high interest to both commercial and Department of Defense organizations, were conducted. The location, type of link, and the data rate achieved for each of the applications is shown. In one demonstration-- an aeronautical terminal experiment called AERO-X--a duplex voice link between an aeronautical terminal on the Lewis Learjet and ACTS was achieved. Two others demonstrated duplex voice links (and in one case, interactive video links as well) between ACTS and an Army high-mobility, multipurpose wheeled vehicle (HMMWV, or "humvee"). In the fourth demonstration, the array was on a fixed mount and was electronically steered toward ACTS. Lewis served as project manager for all demonstrations and as overall system integrator. Lewis engineers developed the array system including a controller for open-loop tracking of ACTS during flight and HMMWV motion, as well as a laptop data display and recording system used in all demonstrations. The Jet Propulsion Laboratory supported the AERO-X program, providing elements of the ACTS Mobile Terminal. The successful performance of experimental, proof-of-concept MMIC K/Ka-band arrays developed with U.S. industry in field demonstrations with ACTS indicates that high density MMIC integration at 20 and 30 GHz is indeed feasible. The successful development and demonstration of the MMIC array systems was possible only because of significant intergovernmental and Government/industry cooperation and the high level of teamwork within Lewis. The results provide a strong incentive for continuing the focused development of MMIC-array technology for satellite communications applications, with emphasis on packaging and cost issues, and for continuing the planning and conducting of other appropriate demonstrations or experiments of phased-array technology with ACTS. Given the present pressures on reducing funding for research and development in Government and industry, the extent to which this can be continued in a cooperative manner will determine whether MMIC array technology will make the transition from the proof-of-concept level to the operational system level.

Integrated Work Management: Overview, Course 31881

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simpson, Lewis Edward

Integrated work management (IWM) is the process used for formally implementing the five-step process associated with integrated safety management (ISM) and integrated safeguards and security management (ISSM) at Los Alamos National Laboratory (LANL). IWM also directly supports the LANL Environmental Management System (EMS). IWM helps all workers and managers perform work safely and securely and in a manner that protects people, the environment, property, and the security of the nation. The IWM process applies to all work activities at LANL, from working in the office to designing experiments to assembling and detonating explosives. The primary LANL document that establishes andmore » describes IWM requirements is Procedure (P) 300, Integrated Work Management.« less

Integrated flight/propulsion control - Subsystem specifications for performance

NASA Technical Reports Server (NTRS)

Neighbors, W. K.; Rock, Stephen M.

1993-01-01

A procedure is presented for calculating multiple subsystem specifications given a number of performance requirements on the integrated system. This procedure applies to problems where the control design must be performed in a partitioned manner. It is based on a structured singular value analysis, and generates specifications as magnitude bounds on subsystem uncertainties. The performance requirements should be provided in the form of bounds on transfer functions of the integrated system. This form allows the expression of model following, command tracking, and disturbance rejection requirements. The procedure is demonstrated on a STOVL aircraft design.

Integrated Approach to Malaria Control

PubMed Central

Shiff, Clive

2002-01-01

Malaria draws global attention in a cyclic manner, with interest and associated financing waxing and waning according to political and humanitarian concerns. Currently we are on an upswing, which should be carefully developed. Malaria parasites have been eliminated from Europe and North America through the use of residual insecticides and manipulation of environmental and ecological characteristics; however, in many tropical and some temperate areas the incidence of disease is increasing dramatically. Much of this increase results from a breakdown of effective control methods developed and implemented in the 1960s, but it has also occurred because of a lack of trained scientists and control specialists who live and work in the areas of endemic infection. Add to this the widespread resistance to the most effective antimalarial drug, chloroquine, developing resistance to other first-line drugs such as sulfadoxine-pyrimethamine, and resistance of certain vector species of mosquito to some of the previously effective insecticides and we have a crisis situation. Vaccine research has proceeded for over 30 years, but as yet there is no effective product, although research continues in many promising areas. A global strategy for malaria control has been accepted, but there are critics who suggest that the single strategy cannot confront the wide range of conditions in which malaria exists and that reliance on chemotherapy without proper control of drug usage and diagnosis will select for drug resistant parasites, thus exacerbating the problem. An integrated approach to control using vector control strategies based on the biology of the mosquito, the epidemiology of the parasite, and human behavior patterns is needed to prevent continued upsurge in malaria in the endemic areas. PMID:11932233

The World Meteorological Organization Focus on Urban Issues

NASA Astrophysics Data System (ADS)

Terblanche, D. E.

2015-12-01

Many of the milestones of human development can be traced back to people assembled in urban settings where economies of scale, competition and social interaction stimulated innovation. Considering that more than half the global pollution now lives in cities and towns and that most of the growth in the global pollution in the remainder of this century will continue to take place in the urban environment, the question could be asked whether humankind will continue to capitalize on the traditional benefits of city life to find solutions for growing environmental challenges? In the past cities developed organically. They evolved through trial and error into livable environments. Things have now changed. The global population is larger, urbanization is rapid, pressure on Earth's limited resources is constraining and we are faced with a changing climate. If cities are now allowed to develop in a haphazard manner, the fight for survival in the city will overshadow its entrepreneurial spirit. It is for this reason that the 11th Sustainable Development Goal will focus on: 'Making cities and human settlements inclusive, safe, resilient and sustainable'. There is now a window of opportunity for weather, climate, water and environmental scientists to contribute towards a more sustainable urban future by ensuring that science based services form an integrated part of urban planning, development and management. WMO recognizes that rapid urbanization will require new types of new and enhanced services. Such integrated urban weather, environment and climate services will assist cities to deal better with hazards such as storm surge, flooding, heat waves, and air pollution episodes, especially in a changing climate. From a research perspective the World Climate Research Programme, the World Weather Research Programme and the Global Atmosphere Watch Programme all have a unique contribution to make in this regard.

[Acute Care Rehabilitation is the First Link in a Chain of Rehabilitation Interventions].

PubMed

Beyer, Joachim; Seidel, Egbert J

2017-08-01

An early, intensive rehabilitative therapy accelerates the recovery of the functions of patients. It contributes to a reduction in the complication rate as well as an improvement in physical and social functioning/participation in the long-term follow-up. Early rehabilitation must be strengthened on the basis of the existing structures: the creation and maintenance of adequately qualified early-stage rehabilitation facilities, at least in hospitals with priority and maximum supply contracts. Patients with long-term intensive care and polytrauma must be rehabilitated as soon as possible (intensive medical rehabilitation).Specialists in physical and rehabilitative medicine, rehabilitative geriatrists, neurologists, orthopaedists and accident surgeons and other regional physicians must cooperate in a targeted manner. Exclusion criteria using corresponding OPS codes must be canceled. Additional specialist physician groups (anesthetists and intensive care physicians, general practitioners, accident and thoracic surgeons, internists) must be sensitized to the importance of early rehabilitation.In the case of more than 500,000 hospital beds, 25,000 beds should be identified as age- and diagnosis-independent early-care beds in the country-specific bed-care plans. A cost-covering financing of the different, personal and cost-intensive early rehabilitation must be ensured. A phase model similar to the BAR guidelines for neurological-neurosurgical early rehabilitation is to be considered for other disease entities.In order to make the rehabilitation process as successful as possible, medical (acute) treatment, medical rehabilitation, occupational integration and social integration have to be understood as a holistic event and are effectively interrelated, as a continuous process which accompanies the entire disease phase-wise. For this purpose, a continuous case management or a rehabilitation guidance has to be established. © Georg Thieme Verlag KG Stuttgart · New York.

Investigation of organic matter migrating from polymeric pipes into drinking water under different flow manners.

PubMed

Zhang, Ling; Liu, Shuming; Liu, Wenjun

2014-02-01

Polymeric pipes, such as unplasticized polyvinyl chloride (uPVC) pipes, polypropylene random (PPR) pipes and polyethylene (PE) pipes are increasingly used for drinking water distribution lines. Plastic pipes may include some additives like metallic stabilizers and other antioxidants for the protection of the material during its production and use. Thus, some compounds can be released from those plastic pipes and cast a shadow on drinking water quality. This work develops a new procedure to investigate three types of polymer pipes (uPVC, PE and PPR) with respect to the migration of total organic carbon (TOC) into drinking water. The migration test was carried out in stagnant conditions with two types of migration processes, a continuous migration process and a successive migration process. These two types of migration processes are specially designed to mimic the conditions of different flow manners in drinking water pipelines, i.e., the situation of continuous stagnation with long hydraulic retention times and normal flow status with regular water renewing in drinking water networks. The experimental results showed that TOC release differed significantly with different plastic materials and under different flow manners. The order of materials with respect to the total amount of TOC migrating into drinking water was observed as PE > PPR > uPVC under both successive and continuous migration conditions. A higher amount of organic migration from PE and PPR pipes was likely to occur due to more organic antioxidants being used in pipe production. The results from the successive migration tests indicated the trend of the migration intensity of different pipe materials over time, while the results obtained from the continuous migration tests implied that under long stagnant conditions, the drinking water quality could deteriorate quickly with the consistent migration of organic compounds and the dramatic consumption of chlorine to a very low level. Higher amounts of TOC were released under the continuous migration tests.

Semiannual Report: Oct 1, 2009 - Mar 31, 2010

EPA Pesticide Factsheets

Semiannual Report #EPA-350-R-10-004, May, 2010. EPA continues to face challenges in using its funds and accomplishing its mission in an efficient and effective manner, particularly concerning Recovery Act projects.

An Efficient Taguchi Approach for the Performance Optimization of Health, Safety, Environment and Ergonomics in Generation Companies.

PubMed

Azadeh, Ali; Sheikhalishahi, Mohammad

2015-06-01

A unique framework for performance optimization of generation companies (GENCOs) based on health, safety, environment, and ergonomics (HSEE) indicators is presented. To rank this sector of industry, the combination of data envelopment analysis (DEA), principal component analysis (PCA), and Taguchi are used for all branches of GENCOs. These methods are applied in an integrated manner to measure the performance of GENCO. The preferred model between DEA, PCA, and Taguchi is selected based on sensitivity analysis and maximum correlation between rankings. To achieve the stated objectives, noise is introduced into input data. The results show that Taguchi outperforms other methods. Moreover, a comprehensive experiment is carried out to identify the most influential factor for ranking GENCOs. The approach developed in this study could be used for continuous assessment and improvement of GENCO's performance in supplying energy with respect to HSEE factors. The results of such studies would help managers to have better understanding of weak and strong points in terms of HSEE factors.

Adaptive optics correction into single mode fiber for a low Earth orbiting space to ground optical communication link using the OPALS downlink.

PubMed

Wright, Malcolm W; Morris, Jeffery F; Kovalik, Joseph M; Andrews, Kenneth S; Abrahamson, Matthew J; Biswas, Abhijit

2015-12-28

An adaptive optics (AO) testbed was integrated to the Optical PAyload for Lasercomm Science (OPALS) ground station telescope at the Optical Communications Telescope Laboratory (OCTL) as part of the free space laser communications experiment with the flight system on board the International Space Station (ISS). Atmospheric turbulence induced aberrations on the optical downlink were adaptively corrected during an overflight of the ISS so that the transmitted laser signal could be efficiently coupled into a single mode fiber continuously. A stable output Strehl ratio of around 0.6 was demonstrated along with the recovery of a 50 Mbps encoded high definition (HD) video transmission from the ISS at the output of the single mode fiber. This proof of concept demonstration validates multi-Gbps optical downlinks from fast slewing low-Earth orbiting (LEO) spacecraft to ground assets in a manner that potentially allows seamless space to ground connectivity for future high data-rates network.

NOVEL ROLES FOR INSULIN RECEPTOR (IR) IN ADIPOCYTES AND SKELETAL MUSCLE CELLS VIA NEW AND UNEXPECTED SUBSTRATES

PubMed Central

Ramalingam, Latha; Oh, Eunjin; Thurmond, Debbie C.

2012-01-01

The insulin signaling pathway regulates whole-body glucose homeostasis by transducing extracellular signals from the insulin receptor (IR) to downstream intracellular targets, thus coordinating a multitude of biological functions. Dysregulation of IR or its signal transduction is associated with insulin resistance, which may culminate in type 2 diabetes (T2D). Following initial stimulation of IR, insulin signaling diverges into different pathways, activating multiple substrates which have roles in various metabolic and cellular processes. The integration of multiple pathways arising from IR activation continues to expand as new IR substrates are identified and characterized. Accordingly, our review will focus on roles for IR substrates as they pertain to three primary areas: Metabolism/glucose uptake, Mitogenesis/growth, and Aging/Longevity. While IR functions in a seemingly pleotropic manner in many cell types, through these three main roles in fat and skeletal muscle cells, IR multi-tasks to regulate whole-body glucose homeostasis to impact healthspan and lifespan. PMID:23052216

Rap as a roadway: creating creolized forms of science in an era of cultural globalization

NASA Astrophysics Data System (ADS)

Elmesky, Rowhea

2011-03-01

Even during an era of cultural globalization where diversity, hybridity, and heterogeneity prevail, educational institutions remain unchanged and economically and racially marginalized students continue to experience a sense of exclusion in school. Whereas the science education community often addresses such exclusion in terms of the achievement gap or the lack of materials and qualified teachers in urban schools, there are also more subtle ways in which these students remain as outsiders to the culture of science. The study highlights how the acceptance and affordance of students' cultural capital can encourage a sense of belonging with school science. Specifically, this paper contributes to the literature by sharing longitudinal findings that reveal students' skills of orality, in the form of rap practices, can be rich resources for developing creolized forms of school science, and how rap creates entryways for students to form and reform hybridized identities in which canonical science discourse and lyrics about non-science subjects can begin to emerge in integrated, fluid and seamless manners.

Unidata and the Hydrologic Community

NASA Astrophysics Data System (ADS)

Weber, W. J.; May, R.; Ho, Y.; Domenico, B.

2016-12-01

The Unidata Program Center, in a cooperative research and development agreement with Amazon Web Services (AWS) and the National Oceanographic and Atmospheric Administration (NOAA) have populated an S3 AWS storage bucket withNEXRAD level II data. The data holdings begin with 1991 and are being kept current using the Unidata Local Data Manager(LDM) software to deliver real time data to the S3 bucket. Having this collection of data available creates thecapability to do research on historical events or longitudinal studies with ease. This collection of radar data alsofacilitates the placement of services near the data for data proximate analysis over large data holdings. Unidata has encouraged community members to place data access services on this collection and has implemented a THREDDS server onthe collection for .edu use. Unidata also continues to advance the development of the Integrated Data Viewer (IDV) tohandle output from WRF-Hydro in a easy and seamless manner that allows sharing and streaming public access of the WRF-Hydromodel output.

Continuous-wave organic dye lasers and methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shapira, Ofer; Chua, Song-Liang; Zhen, Bo

2014-09-16

An organic dye laser produces a continuous-wave (cw) output without any moving parts (e.g., without using flowing dye streams or spinning discs of solid-state dye media to prevent photobleaching) and with a pump beam that is stationary with respect to the organic dye medium. The laser's resonant cavity, organic dye medium, and pump beam are configured to excite a lasing transition over a time scale longer than the associated decay lifetimes in the organic dye medium without photobleaching the organic dye medium. Because the organic dye medium does not photobleach when operating in this manner, it may be pumped continuouslymore » so as to emit a cw output beam. In some examples, operation in this manner lowers the lasing threshold (e.g., to only a few Watts per square centimeter), thereby facilitating electrical pumping for cw operation.« less

RISMC Toolkit and Methodology Research and Development Plan for External Hazards Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coleman, Justin Leigh

This report includes the description and development plan for a Risk Informed Safety Margins Characterization (RISMC) toolkit and methodology that will evaluate multihazard risk in an integrated manner to support the operating nuclear fleet.

Effects of Repair on Structural Integrity.

DOT National Transportation Integrated Search

1993-12-01

Commercial aircraft operators are required by FAA regulations to repair damaged aircraft structures. These repairs must be performed in a timely manner to reduce aircraft downtime and loss of revenue. A guiding principle that has been used for many a...

Business Manners: An Important Aspect of Oral and Nonverbal Communication.

ERIC Educational Resources Information Center

Chaney, Lillian H.

1991-01-01

Discusses business etiquette and addresses such issues as making introductions, speaking effectively, and managing social functions. Determines students' needs, surveys personnel managers, and offers suggestions for integrating social skills into business communication and other business courses. (PRA)

7 CFR 56.33 - Report of violations

Code of Federal Regulations, 2011 CFR

2011-01-01

... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) VOLUNTARY GRADING OF SHELL EGGS Grading of Shell Eggs Reports § 56.33 Report of violations Each grader shall report, in the manner...

7 CFR 56.33 - Report of violations

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) VOLUNTARY GRADING OF SHELL EGGS Grading of Shell Eggs Reports § 56.33 Report of violations Each grader shall report, in the manner...

Tapered bed bioreactor

DOEpatents

Scott, Charles D.; Hancher, Charles W.

1977-01-01

A vertically oriented conically shaped column is used as a fluidized bed bioreactor wherein biologically catalyzed reactions are conducted in a continuous manner. The column utilizes a packing material a support having attached thereto a biologically active catalytic material.

Class, Culture, and Curriculum: A Study of Continuity and Change in a Catholic School. EED433 Management of Resources in Schools.

ERIC Educational Resources Information Center

Angus, Lawrence

This monograph presents a fictionalized case study of a real Catholic school in Australian society, Christian Brothers College (C.B.C.), which illustrates the manner in which "forces" for both continuity and change are negotiated at C.B.C. After a brief introduction, the volume opens with four thematic papers by separate authors,…

Privacy preserving integration of health care data.

PubMed

Adam, Nabil; White, Tom; Shafiq, Basit; Vaidya, Jaideep; He, Xiaoyun

2007-10-11

For health care related research studies the medical records of patients may need to be retrieved from multiple sites with different regulations on the disclosure of health information. Given the sensitive nature of health care information, privacy is a major concern when patients' health care data is used for research purposes. In this paper, we propose an approach for integration and querying of health care data from multiple sources in a secure and privacy preserving manner.

Integrated analysis of remote sensing products from basic geological surveys. [Brazil

NASA Technical Reports Server (NTRS)

Dasilvafagundesfilho, E. (Principal Investigator)

1984-01-01

Recent advances in remote sensing led to the development of several techniques to obtain image information. These techniques as effective tools in geological maping are analyzed. A strategy for optimizing the images in basic geological surveying is presented. It embraces as integrated analysis of spatial, spectral, and temporal data through photoptic (color additive viewer) and computer processing at different scales, allowing large areas survey in a fast, precise, and low cost manner.

Enhancing Privacy in Participatory Sensing Applications with Multidimensional Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forrest, Stephanie; He, Wenbo; Groat, Michael

2013-01-01

Participatory sensing applications rely on individuals to share personal data to produce aggregated models and knowledge. In this setting, privacy concerns can discourage widespread adoption of new applications. We present a privacy-preserving participatory sensing scheme based on negative surveys for both continuous and multivariate categorical data. Without relying on encryption, our algorithms enhance the privacy of sensed data in an energy and computation efficient manner. Simulations and implementation on Android smart phones illustrate how multidimensional data can be aggregated in a useful and privacy-enhancing manner.

Unmanned aircraft system sense and avoid integrity and continuity

NASA Astrophysics Data System (ADS)

Jamoom, Michael B.

This thesis describes new methods to guarantee safety of sense and avoid (SAA) functions for Unmanned Aircraft Systems (UAS) by evaluating integrity and continuity risks. Previous SAA efforts focused on relative safety metrics, such as risk ratios, comparing the risk of using an SAA system versus not using it. The methods in this thesis evaluate integrity and continuity risks as absolute measures of safety, as is the established practice in commercial aircraft terminal area navigation applications. The main contribution of this thesis is a derivation of a new method, based on a standard intruder relative constant velocity assumption, that uses hazard state estimates and estimate error covariances to establish (1) the integrity risk of the SAA system not detecting imminent loss of '"well clear," which is the time and distance required to maintain safe separation from intruder aircraft, and (2) the probability of false alert, the continuity risk. Another contribution is applying these integrity and continuity risk evaluation methods to set quantifiable and certifiable safety requirements on sensors. A sensitivity analysis uses this methodology to evaluate the impact of sensor errors on integrity and continuity risks. The penultimate contribution is an integrity and continuity risk evaluation where the estimation model is refined to address realistic intruder relative linear accelerations, which goes beyond the current constant velocity standard. The final contribution is an integrity and continuity risk evaluation addressing multiple intruders. This evaluation is a new innovation-based method to determine the risk of mis-associating intruder measurements. A mis-association occurs when the SAA system incorrectly associates a measurement to the wrong intruder, causing large errors in the estimated intruder trajectories. The new methods described in this thesis can help ensure safe encounters between aircraft and enable SAA sensor certification for UAS integration into the National Airspace System.

Weed control without herbicides

USDA-ARS?s Scientific Manuscript database

Managing weeds without herbicides is challenging and requires an integration of tactics and a change in how weeds problems are approached. Weeds should be managed in a holistic, intentional and proactive manner. Growers that successfully manage weeds in organic systems examine why certain weed speci...

Learning and inference using complex generative models in a spatial localization task.

PubMed

Bejjanki, Vikranth R; Knill, David C; Aslin, Richard N

2016-01-01

A large body of research has established that, under relatively simple task conditions, human observers integrate uncertain sensory information with learned prior knowledge in an approximately Bayes-optimal manner. However, in many natural tasks, observers must perform this sensory-plus-prior integration when the underlying generative model of the environment consists of multiple causes. Here we ask if the Bayes-optimal integration seen with simple tasks also applies to such natural tasks when the generative model is more complex, or whether observers rely instead on a less efficient set of heuristics that approximate ideal performance. Participants localized a "hidden" target whose position on a touch screen was sampled from a location-contingent bimodal generative model with different variances around each mode. Over repeated exposure to this task, participants learned the a priori locations of the target (i.e., the bimodal generative model), and integrated this learned knowledge with uncertain sensory information on a trial-by-trial basis in a manner consistent with the predictions of Bayes-optimal behavior. In particular, participants rapidly learned the locations of the two modes of the generative model, but the relative variances of the modes were learned much more slowly. Taken together, our results suggest that human performance in a more complex localization task, which requires the integration of sensory information with learned knowledge of a bimodal generative model, is consistent with the predictions of Bayes-optimal behavior, but involves a much longer time-course than in simpler tasks.

Continuous Improvement and the Safety Case for the Waste Isolation Pilot Plant Geologic Repository - 13467

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Luik, Abraham; Patterson, Russell; Nelson, Roger

2013-07-01

The Waste Isolation Pilot Plant (WIPP) is a geologic repository 2150 feet (650 m) below the surface of the Chihuahuan desert near Carlsbad, New Mexico. WIPP permanently disposes of transuranic waste from national defense programs. Every five years, the U.S. Department of Energy (DOE) submits an application to the U.S. Environmental Protection Agency (EPA) to request regulatory-compliance re-certification of the facility for another five years. Every ten years, DOE submits an application to the New Mexico Environment Department (NMED) for the renewal of its hazardous waste disposal permit. The content of the applications made by DOE to the EPA formore » re-certification, and to the NMED for permit-renewal, reflect any optimization changes made to the facility, with regulatory concurrence if warranted by the nature of the change. DOE points to such changes as evidence for its having taken seriously its 'continuous improvement' operations and management philosophy. Another opportunity for continuous improvement is to look at any delta that may exist between the re-certification and re-permitting cases for system safety and the consensus advice on the nature and content of a safety case as being developed and published by the Nuclear Energy Agency's Integration Group for the Safety Case (IGSC) expert group. DOE at WIPP, with the aid of its Science Advisor and teammate, Sandia National Laboratories, is in the process of discerning what can be done, in a reasonably paced and cost-conscious manner, to continually improve the case for repository safety that is being made to the two primary regulators on a recurring basis. This paper will discuss some aspects of that delta and potential paths forward to addressing them. (authors)« less

On integrability of the Killing equation

NASA Astrophysics Data System (ADS)

Houri, Tsuyoshi; Tomoda, Kentaro; Yasui, Yukinori

2018-04-01

Killing tensor fields have been thought of as describing the hidden symmetry of space(-time) since they are in one-to-one correspondence with polynomial first integrals of geodesic equations. Since many problems in classical mechanics can be formulated as geodesic problems in curved space and spacetime, solving the defining equation for Killing tensor fields (the Killing equation) is a powerful way to integrate equations of motion. Thus it has been desirable to formulate the integrability conditions of the Killing equation, which serve to determine the number of linearly independent solutions and also to restrict the possible forms of solutions tightly. In this paper, we show the prolongation for the Killing equation in a manner that uses Young symmetrizers. Using the prolonged equations, we provide the integrability conditions explicitly.

45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.123 Early termination... require that department or agency support for any project be terminated or suspended in the manner...

45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.123 Early termination... require that department or agency support for any project be terminated or suspended in the manner...

45 CFR 690.123 - Early termination of research support: Evaluation of applications and proposals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.123 Early termination... require that department or agency support for any project be terminated or suspended in the manner...

High-purity and label-free isolation of circulating tumor cells (CTCs) in a microfluidic platform by using optically-induced-dielectrophoretic (ODEP) force.

PubMed

Huang, Song-Bin; Wu, Min-Hsien; Lin, Yen-Heng; Hsieh, Chia-Hsun; Yang, Chih-Liang; Lin, Hung-Chih; Tseng, Ching-Ping; Lee, Gwo-Bin

2013-04-07

Negative selection-based circulating tumor cell (CTC) isolation is believed valuable to harvest more native, and in particular all possible CTCs without biases relevant to the properties of surface antigens on the CTCs. Under such a cell isolation strategy, however, the CTC purity is normally compromised. To address this issue, this study reports the integration of optically-induced-dielectrophoretic (ODEP) force-based cell manipulation, and a laminar flow regime in a microfluidic platform for the isolation of untreated, and highly pure CTCs after conventional negative selection-based CTC isolation. In the design, six sections of moving light-bar screens were continuously and simultaneously exerted in two parallel laminar flows to concurrently separate the cancer cells from the leukocytes based on their size difference and electric properties. The separated cell populations were further partitioned, delivered, and collected through the two flows. With this approach, the cancer cells can be isolated in a continuous, effective, and efficient manner. In this study, the operating conditions of ODEP for the manipulation of prostate cancer (PC-3) and human oral cancer (OEC-M1) cells, and leukocytes with minor cell aggregation phenomenon were first characterized. Moreover, performances of the proposed method for the isolation of cancer cells were experimentally investigated. The results showed that the presented CTC isolation scheme was able to isolate PC-3 cells or OEC-M1 cells from a leukocyte background with high recovery rate (PC-3 cells: 76-83%, OEC-M1 cells: 61-68%), and high purity (PC-3 cells: 74-82%, OEC-M1 cells: 64-66%) (set flow rate: 0.1 μl min(-1) and sample volume: 1 μl). The latter is beyond what is currently possible in the conventional CTC isolations. Moreover, the viability of isolated cancer cells was evaluated to be as high as 94 ± 2%, and 95 ± 3% for the PC-3, and OEC-M1 cells, respectively. Furthermore, the isolated cancer cells were also shown to preserve their proliferative capability. As a whole, this study has presented an ODEP-based microfluidic platform that is capable of isolating CTCs in a continuous, label-free, cell-friendly, and particularly highly pure manner. All these traits are found particularly meaningful for exploiting the harvested CTCs for the subsequent cell-based, or biochemical assays.

An integrated lean-methods approach to hospital facilities redesign.

PubMed

Nicholas, John

2012-01-01

Lean production methods for eliminating waste and improving processes in manufacturing are now being applied in healthcare. As the author shows, the methods are appropriate for redesigning hospital facilities. When used in an integrated manner and employing teams of mostly clinicians, the methods produce facility designs that are custom-fit to patient needs and caregiver work processes, and reduce operational costs. The author reviews lean methods and an approach for integrating them in the redesign of hospital facilities. A case example of the redesign of an emergency department shows the feasibility and benefits of the approach.

7 CFR 3430.310 - Allocation of AFRI funds.

Code of Federal Regulations, 2014 CFR

2014-01-01

... integrated multifunctional projects in an appropriate manner and in accordance with the allocation... agricultural sciences. (d) Rapid Response Food and Agricultural Science for Emergency Issues Awards. The Secretary may allocate some funding to address emergency issues in the food and agricultural sciences as...

7 CFR 3430.310 - Allocation of AFRI funds.

Code of Federal Regulations, 2012 CFR

2012-01-01

... integrated multifunctional projects in an appropriate manner and in accordance with the allocation... agricultural sciences. (d) Rapid Response Food and Agricultural Science for Emergency Issues Awards. The Secretary may allocate some funding to address emergency issues in the food and agricultural sciences as...

7 CFR 3430.310 - Allocation of AFRI funds.

Code of Federal Regulations, 2013 CFR

2013-01-01

... integrated multifunctional projects in an appropriate manner and in accordance with the allocation... agricultural sciences. (d) Rapid Response Food and Agricultural Science for Emergency Issues Awards. The Secretary may allocate some funding to address emergency issues in the food and agricultural sciences as...

Integrated transportation and land use models : systems approaches and applications for modeling transport alternatives.

DOT National Transportation Integrated Search

2012-01-20

Ever since World War II, decision makers concerned with transportation and the transportation infrastructure have strived to transport and deliver goods and services to consumers in the most efficient manner possible for economic well-being. Only rec...

Managing weeds in potato rotations without herbicides

USDA-ARS?s Scientific Manuscript database

Managing weeds without herbicides requires an integration of methods and strategies and a change in how weeds are perceived. Weeds should be managed in a holistic, intentional and proactive manner. Successful weed management in organic systems attempts to understand the interactions between the crop...

Implementation of Systematic Review Tools in IRIS

EPA Science Inventory

Currently, the number of chemicals present in the environment exceeds the ability of public health scientists to efficiently screen the available data in order to produce well-informed human health risk assessments in a timely manner. For this reason, the US EPA’s Integrate...

The Role of a Provider-Sponsored Health Plan in Achieving Scale and Integration.

PubMed

Johnson, Steven P

2016-01-01

In pursuit of two primary strategies-to become an integrated delivery network (IDN) on the local level and to achieve additional overall organizational scale to sustain operations-Health First, based in Rockledge, Florida, relies on the success of its provider-sponsored health plan (PSHP) as a critical asset. For Health First, the PSHP serves as an agent for holding and administering financial risk for the health of populations. In addition, we are learning that our PSHP is a critical asset in support of integrating the components of our care delivery system to manage that financial risk effectively, efficiently, and in a manner that creates a unified experience for the customer.Health First is challenged by continuing pressure on reimbursement, as well as by a substantial regulatory burden, as we work to optimize the environments and tools of care and population health management. Even with strong margins and a healthy balance sheet, we simply do not have the resources needed to bring an IDN robustly to life. However, we have discovered that our PSHP can be the vehicle that carries us to additional scale. Many health systems do not own or otherwise have access to a PSHP to hold and manage financial risk. Health First sought and found a not-for-profit health system with complementary goals and a strong brand to partner with, and we now provide private-label health plan products for that system using its strong name while operating the insurance functions under our license and with our capabilities.

SOCR data dashboard: an integrated big data archive mashing medicare, labor, census and econometric information.

PubMed

Husain, Syed S; Kalinin, Alexandr; Truong, Anh; Dinov, Ivo D

Intuitive formulation of informative and computationally-efficient queries on big and complex datasets present a number of challenges. As data collection is increasingly streamlined and ubiquitous, data exploration, discovery and analytics get considerably harder. Exploratory querying of heterogeneous and multi-source information is both difficult and necessary to advance our knowledge about the world around us. We developed a mechanism to integrate dispersed multi-source data and service the mashed information via human and machine interfaces in a secure, scalable manner. This process facilitates the exploration of subtle associations between variables, population strata, or clusters of data elements, which may be opaque to standard independent inspection of the individual sources. This a new platform includes a device agnostic tool (Dashboard webapp, http://socr.umich.edu/HTML5/Dashboard/) for graphical querying, navigating and exploring the multivariate associations in complex heterogeneous datasets. The paper illustrates this core functionality and serviceoriented infrastructure using healthcare data (e.g., US data from the 2010 Census, Demographic and Economic surveys, Bureau of Labor Statistics, and Center for Medicare Services) as well as Parkinson's Disease neuroimaging data. Both the back-end data archive and the front-end dashboard interfaces are continuously expanded to include additional data elements and new ways to customize the human and machine interactions. A client-side data import utility allows for easy and intuitive integration of user-supplied datasets. This completely open-science framework may be used for exploratory analytics, confirmatory analyses, meta-analyses, and education and training purposes in a wide variety of fields.

Integration of the Peruvian Air Force Information Systems through an Integrated LAN/WAN

DTIC Science & Technology

1991-03-01

telecommunication systems are virtually indistinguishable from computer systems. These two technologies meet to work together. 3. Types of Telecommunications...information are virtually out of control. What limits on access exist tend to be the result of habit and tradition, as well as of the sheer difficulty...organization cannot be related to one another, it is virtually impossible for information to be shared or accessed in a timely manner. D. PZRUVIAN AIR FORCE

Soldier Perceptions of the Rapid Decision Trainer

DTIC Science & Technology

2005-05-01

utility. "* Integrated 3D spatialized sound, supporting SCORM Integration the most common sound formats including Wav and Midi . A major objective of this...34low" and "very low" ratings in a similar manner for the lowest ratings categories. Pre-LFX Questionnaire Overall training value of the RDT. Lieutenants...on school computers and has issues are similar to ActiveX, however applets issued the RDT on CD-ROM to each IOBC student installed on the client

Basurto-IGPP. A manual-directed approach of integrative group psychotherapy in psychosis.

PubMed

Ruiz-Parra, Eduardo; González-Torres, M A; Eguiluz, I; de la Sierra, E; Trojaola, B; Catalán, A

2010-01-01

A manual on Integrative Group Psychotherapy for outpatients with schizophrenia and other psychoses (Basurto-PGIP) is presented. The model takes into account group specific therapeutic factors. It integrates influences from other integrative psychotherapeutic models, interpersonal group therapy, group analysis and recent developments in cognitive behavioural therapy for psychotic symptoms. The manual is structured in levels of different complexity that can be applied in a progressive manner. The intervention tries to adapt to patients features, therapists ability and training, and centres resources. It can be applied in two possible settings: a short term closed group and a long term open group. Advantages and disadvantages of the model are described.

Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo

PubMed Central

Ramsey, Simeon J; Attkins, Neil J; Fish, Rebecca; van der Graaf, Piet H

2011-01-01

BACKGROUND AND PURPOSE A series of novel non-peptide corticotropin releasing factor type-1 receptor (CRF1) antagonists were found to display varying degrees of insurmountable and non-competitive behaviour in functional in vitro assays. We describe how we attempted to relate this behaviour to ligand receptor-binding kinetics in a quantitative manner and how this resulted in the development and implementation of an efficient pharmacological screening method based on principles described by Motulsky and Mahan. EXPERIMENTAL APPROACH A non-equilibrium binding kinetic assay was developed to determine the receptor binding kinetics of non-peptide CRF1 antagonists. Nonlinear, mixed-effects modelling was used to obtain estimates of the compounds association and dissociation rates. We present an integrated pharmacokinetic–pharmacodynamic (PKPD) approach, whereby the time course of in vivo CRF1 receptor binding of novel compounds can be predicted on the basis of in vitro assays. KEY RESULTS The non-competitive antagonist behaviour appeared to be correlated to the CRF1 receptor off-rate kinetics. The integrated PKPD model suggested that, at least in a qualitative manner, the in vitro assay can be used to triage and select compounds for further in vivo investigations. CONCLUSIONS AND IMPLICATIONS This study provides evidence for a link between ligand offset kinetics and insurmountable/non-competitive antagonism at the CRF1 receptor. The exact molecular pharmacological nature of this association remains to be determined. In addition, we have developed a quantitative framework to study and integrate in vitro and in vivo receptor binding kinetic behaviour of CRF1 receptor antagonists in an efficient manner in a drug discovery setting. PMID:21449919

Continuous production of polymethylpentene membranes

DOEpatents

Epperson, B.J.; Burnett, L.J.; Helm, V.D.

1983-11-15

Gas separation membranes may be prepared in a continuous manner by passing a porous support which may, if so desired, be backed by a fabric through a solution of polymethylpentene dissolved in an organic solvent such as hexane. The support member is passed through the solution while one side thereof is in contact with a roller, thereby permitting only one side of the support member to be coated with the polymer. After continuously withdrawing the support member from the bath, the solvent is allowed to evaporate and the resulting membrane is recovered.

40 CFR 721.6090 - Phosphoramide.

Code of Federal Regulations, 2010 CFR

2010-07-01

....6090 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT...) Hazard communication program. A significant new use of this substance is any manner or method of manufacture, import, or processing associated with any use of this substance without providing risk...

77 FR 50736 - Self-Regulatory Organizations; National Securities Clearing Corporation; Notice of Filing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... manner.\\8\\ \\5\\ CNS is an ongoing accounting system that nets today's Settling Trades with yesterday's... to be processed through NSCC's Continuous Net Settlement (``CNS'') system \\5\\ (and for CNS-eligible... 50737

Examining TPACK's Theoretical Future

ERIC Educational Resources Information Center

Kimmons, Royce

2015-01-01

TPACK (Technological Pedagogical and Content Knowledge) has quickly become popular amongst researchers and practitioners as a framework for understanding necessary teacher knowledge for supporting effective technology integration. Utilization of TPACK, however, has generally been approached in a manner that is non-critical and that does not inform…

Bug Off

ERIC Educational Resources Information Center

Copps, Patrick T.

2007-01-01

Insects and rodents in education facilities can cause structural damage, and they carry diseases that threaten food safety and the health of students and employees. To effectively prevent infestations and manage pests in a safe and eco-sensitive manner, many schools turn to integrated pest management (IPM) programs that emphasize environmentally…

44 CFR 10.4 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... approach that will ensure the integrated use of the natural and social sciences, and environmental... GENERAL ENVIRONMENTAL CONSIDERATIONS General § 10.4 Policy. (a) FEMA shall act with care to assure that... mitigation and flood insurance, it does so in a manner consistent with national environmental policies. Care...

44 CFR 10.4 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... approach that will ensure the integrated use of the natural and social sciences, and environmental... GENERAL ENVIRONMENTAL CONSIDERATIONS General § 10.4 Policy. (a) FEMA shall act with care to assure that... mitigation and flood insurance, it does so in a manner consistent with national environmental policies. Care...

Development and application of a long dynamic range nitrous oxide monitoring system.

PubMed

Ward, B G

1985-12-01

The laboratory and field evaluation of a nitrous oxide monitor for an extremely wide range of cumulative exposures are reviewed. The passive sampling behavior and high analyte capacity show it to be useful for short-term and full workweek exposure monitoring. The monitor has application for both area and personnel surveillance. The principal criterion is for an accurate report of exposure time of the monitor. Application of the monitor to real workplace environments--with and without a reference method--demonstrated the ability of workweek monitoring as a valuable and potentially superior way of documenting exposure stress of employees. Environmental factors such as humidity and temperature variation are shown to have acceptably small effects on both short- and long-term exposure data; barometric pressure affects the data in a predictable manner. Paired dosimeters show good agreement in the workplace environment throughout the range of 6-40 cumulative hours of exposure. In both hospital and dental operating suites, work logistics and work group relationships were readily traceable on a week-by-week basis during a continuous weekly monitoring program. Source emissions and appropriate worker and work area exposure relationships were clearly evident, with appropriate reduction of all exposures as a result of an abbreviated work schedule. The ability to effectively track employee and area exposure excursions in an integrated weekly manner leads to a whole series of new applications and concepts of industrial hygiene surveillance. Such approaches could effectively replace the speculative statistical approaches currently in use with actual data on a cost effective basis.

PERCEIVED FEASIBILITY OF ESTABLISHING DEDICATED ELDER ABUSE PROGRAMS OF CARE AT HOSPITAL-BASED SEXUAL ASSAULT/DOMESTIC VIOLENCE TREATMENT CENTETR.

PubMed

Du Mont, Janice; Mirzaei, Aftab; Macdonald, Sheila; White, Meghan; Kosa, Daisy; Reimer, Linda

2014-12-01

Elder abuse is an increasingly important issue that must be addressed in a systematic and coordinated way. Our objective was to evaluate the perceived feasibility of establishing an elder abuse care program at hospital-based sexual assault and domestic violence treatment centers in Ontario, Canada. In July 2012, a questionnaire focused on elder abuse care was distributed to all of Ontario's Sexual Assault/Domestic Violence Treatment Centre (SA/DVTC) Program Coordinators/Managers. We found that the majority of Program Coordinators/ Managers favored expansion of their program mandates to include an elder abuse care program. However, these respondents viewed collaboration with a large network of well trained professionals and available services in the community that address elder abuse as integral to responding in a coordinated manner. The expansion of health services to address the needs of abused older adults in a comprehensive and integrated manner should be considered as an important next step for hospital-based violence care programs worldwide.

The Center for Integrated Molecular Brain Imaging (Cimbi) database.

PubMed

Knudsen, Gitte M; Jensen, Peter S; Erritzoe, David; Baaré, William F C; Ettrup, Anders; Fisher, Patrick M; Gillings, Nic; Hansen, Hanne D; Hansen, Lars Kai; Hasselbalch, Steen G; Henningsson, Susanne; Herth, Matthias M; Holst, Klaus K; Iversen, Pernille; Kessing, Lars V; Macoveanu, Julian; Madsen, Kathrine Skak; Mortensen, Erik L; Nielsen, Finn Årup; Paulson, Olaf B; Siebner, Hartwig R; Stenbæk, Dea S; Svarer, Claus; Jernigan, Terry L; Strother, Stephen C; Frokjaer, Vibe G

2016-01-01

We here describe a multimodality neuroimaging containing data from healthy volunteers and patients, acquired within the Lundbeck Foundation Center for Integrated Molecular Brain Imaging (Cimbi) in Copenhagen, Denmark. The data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 and the 5-HT transporter (5-HTT), but can easily serve other purposes. The Cimbi database and Cimbi biobank were formally established in 2008 with the purpose to store the wealth of Cimbi-acquired data in a highly structured and standardized manner in accordance with the regulations issued by the Danish Data Protection Agency as well as to provide a quality-controlled resource for future hypothesis-generating and hypothesis-driven studies. The Cimbi database currently comprises a total of 1100 PET and 1000 structural and functional MRI scans and it holds a multitude of additional data, such as genetic and biochemical data, and scores from 17 self-reported questionnaires and from 11 neuropsychological paper/computer tests. The database associated Cimbi biobank currently contains blood and in some instances saliva samples from about 500 healthy volunteers and 300 patients with e.g., major depression, dementia, substance abuse, obesity, and impulsive aggression. Data continue to be added to the Cimbi database and biobank. Copyright © 2015. Published by Elsevier Inc.

Role of contextual cues on the perception of spectrally reduced interrupted speech.

PubMed

Patro, Chhayakanta; Mendel, Lisa Lucks

2016-08-01

Understanding speech within an auditory scene is constantly challenged by interfering noise in suboptimal listening environments when noise hinders the continuity of the speech stream. In such instances, a typical auditory-cognitive system perceptually integrates available speech information and "fills in" missing information in the light of semantic context. However, individuals with cochlear implants (CIs) find it difficult and effortful to understand interrupted speech compared to their normal hearing counterparts. This inefficiency in perceptual integration of speech could be attributed to further degradations in the spectral-temporal domain imposed by CIs making it difficult to utilize the contextual evidence effectively. To address these issues, 20 normal hearing adults listened to speech that was spectrally reduced and spectrally reduced interrupted in a manner similar to CI processing. The Revised Speech Perception in Noise test, which includes contextually rich and contextually poor sentences, was used to evaluate the influence of semantic context on speech perception. Results indicated that listeners benefited more from semantic context when they listened to spectrally reduced speech alone. For the spectrally reduced interrupted speech, contextual information was not as helpful under significant spectral reductions, but became beneficial as the spectral resolution improved. These results suggest top-down processing facilitates speech perception up to a point, and it fails to facilitate speech understanding when the speech signals are significantly degraded.

A Computational Framework for Quantitative Evaluation of Movement during Rehabilitation

NASA Astrophysics Data System (ADS)

Chen, Yinpeng; Duff, Margaret; Lehrer, Nicole; Sundaram, Hari; He, Jiping; Wolf, Steven L.; Rikakis, Thanassis

2011-06-01

This paper presents a novel generalized computational framework for quantitative kinematic evaluation of movement in a rehabilitation clinic setting. The framework integrates clinical knowledge and computational data-driven analysis together in a systematic manner. The framework provides three key benefits to rehabilitation: (a) the resulting continuous normalized measure allows the clinician to monitor movement quality on a fine scale and easily compare impairments across participants, (b) the framework reveals the effect of individual movement components on the composite movement performance helping the clinician decide the training foci, and (c) the evaluation runs in real-time, which allows the clinician to constantly track a patient's progress and make appropriate adaptations to the therapy protocol. The creation of such an evaluation is difficult because of the sparse amount of recorded clinical observations, the high dimensionality of movement and high variations in subject's performance. We address these issues by modeling the evaluation function as linear combination of multiple normalized kinematic attributes y = Σwiφi(xi) and estimating the attribute normalization function φi(ṡ) by integrating distributions of idealized movement and deviated movement. The weights wi are derived from a therapist's pair-wise comparison using a modified RankSVM algorithm. We have applied this framework to evaluate upper limb movement for stroke survivors with excellent results—the evaluation results are highly correlated to the therapist's observations.

Production of egg white protein hydrolysates with improved antioxidant capacity in a continuous enzymatic membrane reactor: optimization of operating parameters by statistical design.

PubMed

Jakovetić Tanasković, Sonja; Luković, Nevena; Grbavčić, Sanja; Stefanović, Andrea; Jovanović, Jelena; Bugarski, Branko; Knežević-Jugović, Zorica

2018-01-01

This study focuses on the influence of operating conditions on Alcalase-catalyzed egg white protein hydrolysis performed in a continuously stirred tank reactor coupled with ultrafiltration module (10 kDa). The permeate flow rate did not significantly affect the degree of hydrolysis (DH), but a significant increase in process productivity was apparent above flow rate of 1.9 cm 3 min -1 . By contrast, an increase in enzyme/substrate ( E / S ) ratio provided an increase in DH, but a negative correlation was observed between E / S ratio and productivity. The relationship between operating conditions and antioxidant properties of the hydrolysates, measured by three methods, was studied using Box-Behnken experimental design and response surface methodology. The statistical analysis showed that each variable (impeller speed, E / S ratio, and permeate flow rate) had a significant effect on the antioxidant capacity of all tested systems. Nevertheless, obtained response functions revealed that antioxidative activity measured by DPPH, ABTS and FRAP methods were affected differently by the same operating conditions. High impeller speeds and low permeate flow rates favor ABTS while high impeller speeds and high permeate flow rates had a positive effect on the DPPH scavenging activity. On the other hand, the best results obtained with FRAP method were achieved under moderate operating conditions. The integration of the reaction and ultrafiltration membrane separation in a continuous manner appears to be a right approach to improve and intensify the enzymatic process, enabling the production of peptides with desired antioxidant activity.

Faces of integration.

PubMed

Williams, Paul; Sullivan, Helen

2009-12-22

Two central themes permeate this paper-the interplay between structure and agency in integration processes and the extent to which this is mediated through sensemaking by individual actors. The empirical base for the paper is provided by case study research from Wales which draws on examples of different types of integration in health and social care. The individual case studies highlight different interpretations of integration set against a background of the resources involved, processes employed and outcomes achieved. A wide ranging discussion exposes the complex interplay and dynamics between structural factors and the manner in which they enable or constrain integration, and individual actors realising their potential agency through leadership, professionalism and boundary spanning to influence outcomes. The importance of structure and agency complementing each other to determine effective integration is emphasised, together with the scope that is available for interpretation and meaning by individual actors within the contested discourse of integration.

Faces of integration

PubMed Central

Williams, Paul; Sullivan, Helen

2009-01-01

Theme Two central themes permeate this paper—the interplay between structure and agency in integration processes and the extent to which this is mediated through sensemaking by individual actors. Case study The empirical base for the paper is provided by case study research from Wales which draws on examples of different types of integration in health and social care. The individual case studies highlight different interpretations of integration set against a background of the resources involved, processes employed and outcomes achieved. Discussion A wide ranging discussion exposes the complex interplay and dynamics between structural factors and the manner in which they enable or constrain integration, and individual actors realising their potential agency through leadership, professionalism and boundary spanning to influence outcomes. The importance of structure and agency complementing each other to determine effective integration is emphasised, together with the scope that is available for interpretation and meaning by individual actors within the contested discourse of integration. PMID:20087420

Network reconfiguration and neuronal plasticity in rhythm-generating networks.

PubMed

Koch, Henner; Garcia, Alfredo J; Ramirez, Jan-Marino

2011-12-01

Neuronal networks are highly plastic and reconfigure in a state-dependent manner. The plasticity at the network level emerges through multiple intrinsic and synaptic membrane properties that imbue neurons and their interactions with numerous nonlinear properties. These properties are continuously regulated by neuromodulators and homeostatic mechanisms that are critical to maintain not only network stability and also adapt networks in a short- and long-term manner to changes in behavioral, developmental, metabolic, and environmental conditions. This review provides concrete examples from neuronal networks in invertebrates and vertebrates, and illustrates that the concepts and rules that govern neuronal networks and behaviors are universal.

Guidelines for Electromagnetic Interference Testing of Power Plant Equipment: Revision 3 to TR-102323

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. Cunningham and J. Shank

2004-11-01

To continue meeting safety and reliability requirements while controlling costs, operators of nuclear power plants must be able to replace and upgrade equipment in a cost-effective manner. One issue that has been problematic for new plant equipment and especially for digital instrumentation and control (I&C) systems in recent years is electromagnetic compatibility (EMC). The EMC issue usually involves testing to show that critical equipment will not be adversely affected by electromagnetic interference (EMI) in the plant environment. This guide will help nuclear plant engineers address EMC issues and qualification testing in a consistent, comprehensive manner.

10 CFR 60.4 - Communications and records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC... offices at 11555 Rockville Pike, Rockville, Maryland; or, where practicable, by electronic submission, for example, via Electronic Information Exchange, or CD-ROM. Electronic submissions must be made in a manner...

47 CFR 76.1205 - CableCARD support.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... operate with multichannel video programming systems shall be provided by the system operator upon request in a timely manner. (b) A multichannel video programming provider that is subject to the requirements...

7 CFR 1206.106 - Referendum report.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... INFORMATION Referendum Procedures. § 1206.106 Referendum report. Except as otherwise directed, the referendum... manner in which it was conducted, the extent and kind of public notice given, and other information...

Nonequilibrium radiation and chemistry models for aerocapture vehicle flowfields

NASA Technical Reports Server (NTRS)

Carlson, Leland A.

1990-01-01

The continued development and improvement of the viscous shock layer (VSL) nonequilibrium chemistry blunt body engineering code, the incorporation in a coupled manner of radiation models into the VSL code, and the initial development of appropriate precursor models are presented.

42 CFR 493.1495 - Standard; Testing personnel responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... samples are tested in the same manner as patient specimens; (3) Adhere to the laboratory's quality control policies, document all quality control activities, instrument and procedural calibrations and maintenance... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for Nonwaived...

40 CFR 721.9540 - Polysulfide mixture.

Code of Federal Regulations, 2010 CFR

2010-07-01

... new information, and any information on methods for protecting against such risk, into the applicable... 721.9540 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... substance is any manner or method of manufacture, import, or processing associated with any use of this...

Connecticut DOT statewide bus system study : executive summary

DOT National Transportation Integrated Search

2000-07-01

The Connecticut Statewide Bus System Study has been undertaken to ensure that bus transit in Connecticut serves continuing needs in the most efficient manner possible. The Study has taken a comprehensive look at the state's twenty urban and rural tra...

24 CFR 570.905 - Review of continuing capacity to carry out CDBG funded activities in a timely manner.

Code of Federal Regulations, 2011 CFR

2011-04-01

... carried out its CDBG activities and certifications in accordance with the requirements and criteria..., types of corrective actions the recipient has undertaken and the success or likely success of such...

24 CFR 570.905 - Review of continuing capacity to carry out CDBG funded activities in a timely manner.

Code of Federal Regulations, 2010 CFR

2010-04-01

... carried out its CDBG activities and certifications in accordance with the requirements and criteria..., types of corrective actions the recipient has undertaken and the success or likely success of such...

Ongoing evaluation of alternatively fueled buses : final report.

DOT National Transportation Integrated Search

2016-05-01

The goal of this project is to continue collecting and reporting data on the performance and costs of alternatively fueled public transit vehicles in Florida in a consistent manner. Over the course of this project, researchers sent repeated data requ...

SPECIFIC HEAT INDICATOR

DOEpatents

Horn, F.L.; Binns, J.E.

1961-05-01

Apparatus for continuously and automatically measuring and computing the specific heat of a flowing solution is described. The invention provides for the continuous measurement of all the parameters required for the mathematical solution of this characteristic. The parameters are converted to logarithmic functions which are added and subtracted in accordance with the solution and a null-seeking servo reduces errors due to changing voltage drops to a minimum. Logarithmic potentiometers are utilized in a unique manner to accomplish these results.

Colonization and effector functions of innate lymphoid cells in mucosal tissues

PubMed Central

Kim, Myunghoo; Kim, Chang H.

2016-01-01

Innate lymphoid cells (ILCs) protect mucosal barrier tissues to fight infection and maintain tissue integrity. ILCs and their progenitors are developmentally programmed to migrate, differentiate and populate various mucosal tissues and associated lymphoid tissues. Functionally mature ILC subsets respond to diverse pathogens such as bacteria, viruses, fungi and parasites in subset-specific manners. In this review, we will discuss how ILCs populate mucosal tissues and regulate immune responses to distinct pathogens to protect the host and maintain tissue integrity. PMID:27365193

RKKY exchange interaction within the parabolic quantum-well

NASA Astrophysics Data System (ADS)

Baķ, Zygmunt

2001-03-01

Indirect magnetic exchange in a semimagnetic semiconductor heterostructure with the parabolic quantum-well barrier potential is considered. Within the analytical method, we provide the exact derivation of the spatial dependence of the RKKY exchange integral. Using the effective dimensionality approach, we show that the spectral dimensionality of the free electron (hole) system equals four. We prove, that the RKKY exchange integral shows conventional, sign reversal variation with the 2 kF period, however, the envelope function falls off in a manner characteristic to 4D systems.

Translating Pressure Ulcer Prevention Into Intensive Care Nursing Practice: Overlaying a Care Bundle Approach With a Model for Research Implementation.

PubMed

Tayyib, Nahla; Coyer, Fiona

This article reports on the development and implementation process used to integrate a care bundle approach (a pressure ulcer [PU] prevention bundle to improve patients' skin integrity in intensive care) and the Ottawa Model of Research Use (OMRU). The PU prevention care bundle demonstrated significant reduction in PU incidence, with the OMRU model providing a consolidated framework for the implementation of bundled evidence in an effective and consistent manner into daily clinical nursing practice.

Higher-Order Theory for Functionally Graded Materials

NASA Technical Reports Server (NTRS)

Aboudi, J.; Pindera, M. J.; Arnold, Steven M.

2001-01-01

Functionally graded materials (FGM's) are a new generation of engineered materials wherein the microstructural details are spatially varied through nonuniform distribution of the reinforcement phase(s). Engineers accomplish this by using reinforcements with different properties, sizes, and shapes, as well as by interchanging the roles of the reinforcement and matrix phases in a continuous manner (ref. 1). The result is a microstructure that produces continuously or discretely changing thermal and mechanical properties at the macroscopic or continuum scale. This new concept of engineering the material's microstructure marks the beginning of a revolution both in the materials science and mechanics of materials areas since it allows one, for the first time, to fully integrate the material and structural considerations into the final design of structural components. Functionally graded materials are ideal candidates for applications involving severe thermal gradients, ranging from thermal structures in advanced aircraft and aerospace engines to computer circuit boards. Owing to the many variables that control the design of functionally graded microstructures, full exploitation of the FGM's potential requires the development of appropriate modeling strategies for their response to combined thermomechanical loads. Previously, most computational strategies for the response of FGM's did not explicitly couple the material's heterogeneous microstructure with the structural global analysis. Rather, local effective or macroscopic properties at a given point within the FGM were first obtained through homogenization based on a chosen micromechanics scheme and then subsequently used in a global thermomechanical analysis.

Towards the Personalized Treatment of Glioblastoma: Integrating Patient-Specific Clinical Data in a Continuous Mechanical Model

PubMed Central

Faggiano, Elena; Boffano, Carlo; Acerbi, Francesco; Ciarletta, Pasquale

2015-01-01

Glioblastoma multiforme (GBM) is the most aggressive and malignant among brain tumors. In addition to uncontrolled proliferation and genetic instability, GBM is characterized by a diffuse infiltration, developing long protrusions that penetrate deeply along the fibers of the white matter. These features, combined with the underestimation of the invading GBM area by available imaging techniques, make a definitive treatment of GBM particularly difficult. A multidisciplinary approach combining mathematical, clinical and radiological data has the potential to foster our understanding of GBM evolution in every single patient throughout his/her oncological history, in order to target therapeutic weapons in a patient-specific manner. In this work, we propose a continuous mechanical model and we perform numerical simulations of GBM invasion combining the main mechano-biological characteristics of GBM with the micro-structural information extracted from radiological images, i.e. by elaborating patient-specific Diffusion Tensor Imaging (DTI) data. The numerical simulations highlight the influence of the different biological parameters on tumor progression and they demonstrate the fundamental importance of including anisotropic and heterogeneous patient-specific DTI data in order to obtain a more accurate prediction of GBM evolution. The results of the proposed mathematical model have the potential to provide a relevant benefit for clinicians involved in the treatment of this particularly aggressive disease and, more importantly, they might drive progress towards improving tumor control and patient’s prognosis. PMID:26186462

Ties that Do Not Bind.

ERIC Educational Resources Information Center

Maeroff, Gene I.

1982-01-01

Colleges and universities will be affected by the manner in which incoming students have been prepared for postsecondary education. Integration of efforts by colleges and secondary schools in subjects such as mathematics and science are recommended, and some cooperative efforts between higher education and public schools are described. (MLW)

Connecting Undergraduate Plant Cell Biology Students with the Scientists about Whom They Learn: A Bibliography.

ERIC Educational Resources Information Center

Wayne, Randy; Staves, Mark P.

1998-01-01

Details the teaching of an undergraduate plant-cell biology class in the manner proposed by Jean Baptiste Carnoy when he established the first institute of cellular biology. Integrates mathematics, astronomy, physics, chemistry, anatomy, physiology, and ecology. Contains 226 references. (DDR)

Encouraging Creativity in Online University Classes

ERIC Educational Resources Information Center

Muirhead, Brent

2005-01-01

Educational and business literature affirms the importance and value of creativity. Unfortunately, this knowledge is not always presented in a manner that is useful to online instructors who want to integrate more reflective lessons into their courses. The discussion will provide vital background information on creativity and offer relevant…

Quantifying conservation biological control for management of Bemisia tabaci (Hemiptera: Aleyrodidae) in cotton

USDA-ARS?s Scientific Manuscript database

Conservation biological control can be an effective tactic for minimizing insect-induced damage to agricultural production. The most effective manner of applying CBC is through an Integrated Pest Management (IPM) strategy, combining many tactics including cultural controls, pest sampling, the use of...

Using Discovery in the Calculus Class

ERIC Educational Resources Information Center

Shilgalis, Thomas W.

1975-01-01

This article shows how two discoverable theorems from elementary calculus can be presented to students in a manner that assists them in making the generalizations themselves. The theorems are the mean value theorems for derivatives and for integrals. A conjecture is suggested by pictures and then refined. (Author/KM)

Integrated Remote Sensing Modalities for Classification at a Legacy Test Site

NASA Astrophysics Data System (ADS)

Lee, D. J.; Anderson, D.; Craven, J.

2016-12-01

Detecting, locating, and characterizing suspected underground nuclear test sites is of interest to the worldwide nonproliferation monitoring community. Remote sensing provides both cultural and surface geological information over a large search area in a non-intrusive manner. We have characterized a legacy nuclear test site at the Nevada National Security Site (NNSS) using an aerial system based on RGB imagery, light detection and ranging, and hyperspectral imaging. We integrate these different remote sensing modalities to perform pattern recognition and classification tasks on the test site. These tasks include detecting cultural artifacts and exotic materials. We evaluate if the integration of different remote sensing modalities improves classification performance.

45 CFR 1621.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION CLIENT GRIEVANCE PROCEDURES... assistance to clients as required by the LSC Act and are accountable to clients and applicants for legal... about the denial of legal assistance and clients about the manner or quality of legal assistance...

7 CFR 3701.4 - Multitrack processing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Multitrack processing. 3701.4 Section 3701.4 Agriculture Regulations of the Department of Agriculture (Continued) ECONOMIC RESEARCH SERVICE, DEPARTMENT OF... agency responsibility to exercise due diligence in processing requests in the most expeditious manner...

40 CFR 63.1544 - Standards for fugitive dust sources.

Code of Federal Regulations, 2014 CFR

2014-07-01

... associated air pollution control equipment and monitoring equipment, in a manner consistent with safety and good air pollution control practices for minimizing emissions. Determination of whether such operation.... 63.1544 Section 63.1544 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR...

40 CFR 63.1544 - Standards for fugitive dust sources.

Code of Federal Regulations, 2012 CFR

2012-07-01

... associated air pollution control equipment and monitoring equipment, in a manner consistent with safety and good air pollution control practices for minimizing emissions. Determination of whether such operation.... 63.1544 Section 63.1544 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR...

40 CFR 63.1544 - Standards for fugitive dust sources.

Code of Federal Regulations, 2013 CFR

2013-07-01

... associated air pollution control equipment and monitoring equipment, in a manner consistent with safety and good air pollution control practices for minimizing emissions. Determination of whether such operation....1544 Section 63.1544 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

47 CFR 76.62 - Manner of carriage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... broadcast television station carried pursuant to § 76.56 shall include in its entirety the primary video... entirety the primary video, accompanying audio, and closed captioning data contained in line 21 of the...

47 CFR 76.62 - Manner of carriage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... broadcast television station carried pursuant to § 76.56 shall include in its entirety the primary video... entirety the primary video, accompanying audio, and closed captioning data contained in line 21 of the...

47 CFR 76.62 - Manner of carriage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... broadcast television station carried pursuant to § 76.56 shall include in its entirety the primary video... entirety the primary video, accompanying audio, and closed captioning data contained in line 21 of the...

47 CFR 76.62 - Manner of carriage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... broadcast television station carried pursuant to § 76.56 shall include in its entirety the primary video... entirety the primary video, accompanying audio, and closed captioning data contained in line 21 of the...

Applying Semantic Web Services and Wireless Sensor Networks for System Integration

NASA Astrophysics Data System (ADS)

Berkenbrock, Gian Ricardo; Hirata, Celso Massaki; de Oliveira Júnior, Frederico Guilherme Álvares; de Oliveira, José Maria Parente

In environments like factories, buildings, and homes automation services tend to often change during their lifetime. Changes are concerned to business rules, process optimization, cost reduction, and so on. It is important to provide a smooth and straightforward way to deal with these changes so that could be handled in a faster and low cost manner. Some prominent solutions use the flexibility of Wireless Sensor Networks and the meaningful description of Semantic Web Services to provide service integration. In this work, we give an overview of current solutions for machinery integration that combine both technologies as well as a discussion about some perspectives and open issues when applying Wireless Sensor Networks and Semantic Web Services for automation services integration.

Integrative Systems Biology for Data Driven Knowledge Discovery

PubMed Central

Greene, Casey S.; Troyanskaya, Olga G.

2015-01-01

Integrative systems biology is an approach that brings together diverse high throughput experiments and databases to gain new insights into biological processes or systems at molecular through physiological levels. These approaches rely on diverse high-throughput experimental techniques that generate heterogeneous data by assaying varying aspects of complex biological processes. Computational approaches are necessary to provide an integrative view of these experimental results and enable data-driven knowledge discovery. Hypotheses generated from these approaches can direct definitive molecular experiments in a cost effective manner. Using integrative systems biology approaches, we can leverage existing biological knowledge and large-scale data to improve our understanding of yet unknown components of a system of interest and how its malfunction leads to disease. PMID:21044756

Watt-Level Continuous-Wave Emission from a Bi-Functional Quantum Cascade Laser/Detector

DTIC Science & Technology

2017-04-18

facet continuous wave emission at 15◦C. Apart from the general performance benets, this enables sensing techiques which rely on continuous wave...record achieved with strained material at this wavelength. Keywords quantum cascade laser, quantum cascade detector, lab- on -a-chip, monolithic integrated...materials, which makes their integration on Si particularly dicult. Heterogeneous integration using transfer techniques allows both single device and wafer

The systems approach for applying artificial intelligence to space station automation (Invited Paper)

NASA Astrophysics Data System (ADS)

Grose, Vernon L.

1985-12-01

The progress of technology is marked by fragmentation -- dividing research and development into ever narrower fields of specialization. Ultimately, specialists know everything about nothing. And hope for integrating those slender slivers of specialty into a whole fades. Without an integrated, all-encompassing perspective, technology becomes applied in a lopsided and often inefficient manner. A decisionary model, developed and applied for NASA's Chief Engineer toward establishment of commercial space operations, can be adapted to the identification, evaluation, and selection of optimum application of artificial intelligence for space station automation -- restoring wholeness to a situation that is otherwise chaotic due to increasing subdivision of effort. Issues such as functional assignments for space station task, domain, and symptom modules can be resolved in a manner understood by all parties rather than just the person with assigned responsibility -- and ranked by overall significance to mission accomplishment. Ranking is based on the three basic parameters of cost, performance, and schedule. This approach has successfully integrated many diverse specialties in situations like worldwide terrorism control, coal mining safety, medical malpractice risk, grain elevator explosion prevention, offshore drilling hazards, and criminal justice resource allocation -- all of which would have otherwise been subject to "squeaky wheel" emphasis and support of decision-makers.

NATIONAL EXPOSURE RESEARCH LABORATORY (NERL) INTEGRATED INFORMATOIN AND QUALITY MANAGEMENT PLAN TRAINING

EPA Science Inventory

The success of the NERL quality system relies on participation by all managers and staff. This training was developed for the purpose of communicating the basic features of the quality system in a convenient and efficient manner. The total time to complete a review of all five ...

48 CFR 37.104 - Personal services contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Agencies shall not award personal services contracts unless specifically authorized by statute (e.g., 5 U.S... equipment furnished by the Government. (3) Services are applied directly to the integral effort of agencies... which apply in acquiring the personal services of experts or consultants in this manner (e.g., benefits...

48 CFR 37.104 - Personal services contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Agencies shall not award personal services contracts unless specifically authorized by statute (e.g., 5 U.S... equipment furnished by the Government. (3) Services are applied directly to the integral effort of agencies... which apply in acquiring the personal services of experts or consultants in this manner (e.g., benefits...

24 CFR 180.315 - Standards of conduct.

Code of Federal Regulations, 2010 CFR

2010-04-01

... AND BUSINESS OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Parties § 180... integrity and in an ethical manner. (b) The ALJ may exclude parties or their representatives for refusal to... orderly and ethical conduct, failure to act in good faith, or violations of the prohibitions against ex...

Kierkegaard, Justification and the Integrity of Christian Education

ERIC Educational Resources Information Center

Wright, Andrew W.

2015-01-01

The doctrine of justification is frequently interpreted in a manner that excludes our active involvement in the drama of salvation. This reading has a detrimental effect on Christian education concerned to enable the learner's attentive, reasonable and responsible understanding of the Gospel. Taking its lead from Kierkegaard's account of…

INTEGRATION OF MECHANISTIC DATA INTO THE WEIGHT EVIDENCE CONSIDERATIONS FOR RISK ASSESSMENT OF DEVELOPMENTAL EXPOSURE TO CHLORPYRIFOS.

EPA Science Inventory

The susceptibility of the developing nervous system to damage following exposure to environmental contaminants is believed to be based upon the critical nature of the organizational events that occur in both a regionally- and temporally-dependent manner. The age-related susceptib...

INTEGRATED RESEARCH PLAN FOR LINKING BMPS AND WATERSHED WATER QUALITY IN SOUTHERN OHIO

EPA Science Inventory

Although it is routine for watershed management programs to coincide the monitoring of land use impacts and water quality at different spatial scales, rarely are the data collected or analyzed in such a strategic manner to be able to study the linkages among ecological systems ac...

Systemic Planning: An Annotated Bibliography and Literature Guide. Exchange Bibliography No. 91.

ERIC Educational Resources Information Center

Catanese, Anthony James

Systemic planning is an operational approach to using scientific rigor and qualitative judgment in a complementary manner. It integrates rigorous techniques and methods from systems analysis, cybernetics, decision theory, and work programing. The annotated reference sources in this bibliography include those works that have been most influential…

Demonstration of Green/Gray Infrastructure for Combined Sewer Overflow Control

EPA Science Inventory

This project is a major national demonstration of the integration of green and gray infrastructure for combined sewer overflow (CSO) control in a cost-effective and environmentally friendly manner. It will use Kansas City, MO, as a case example. The project will have a major in...

Consumer Education in the English Curriculum. Monograph 5.

ERIC Educational Resources Information Center

Greenspan, Nancy B.; Johnston, William L.

Consumer education should be integrated throughout the curriculum in an inter-disciplinary manner. English teachers have unparalleled opportunity to provide students with excellent foundations for critical and interpretive reading and thinking in the area of advertising, as they are involved with reading, vocabulary building, and both oral and…

Teaching Disturbed and Disturbing Students: An Integrative Approach. Second Edition.

ERIC Educational Resources Information Center

Zionts, Paul

This book examines intervention with children having emotional or behavioral disorders (EBD), through the use of many case studies, activities, and examples. The text is organized in a developmental manner, with behavioral interventions recommended for lower grades and cognitive-behavioral approaches recommended for older students. The first unit…

Career Pathways in School-to-Work Systems. Resource Bulletin.

ERIC Educational Resources Information Center

National School-to-Work Opportunities Office, Washington, DC.

Many students in today's high schools choose courses and work experiences in an unplanned, aimless manner that often results in limited career options and undeveloped potential. Innovative educators across the nation have responded by restructuring schools around career pathways, which are integrated, multiyear sequences of career guidance,…

Cross Course Collaboration in Undergraduate Sociology Programs

ERIC Educational Resources Information Center

Waltermaurer, Eve; Obach, Brian

2007-01-01

In this article, the authors describe a cross course collaborative research project designed to provide students with an opportunity to integrate aspects of sociological study that are typically addressed in a compartmentalized course by course manner. They used this approach on two separate occasions. The first involved collaboration between a…

Two-Step Fair Scheduling of Continuous Media Streams over Error-Prone Wireless Channels

NASA Astrophysics Data System (ADS)

Oh, Soohyun; Lee, Jin Wook; Park, Taejoon; Jo, Tae-Chang

In wireless cellular networks, streaming of continuous media (with strict QoS requirements) over wireless links is challenging due to their inherent unreliability characterized by location-dependent, bursty errors. To address this challenge, we present a two-step scheduling algorithm for a base station to provide streaming of continuous media to wireless clients over the error-prone wireless links. The proposed algorithm is capable of minimizing the packet loss rate of individual clients in the presence of error bursts, by transmitting packets in the round-robin manner and also adopting a mechanism for channel prediction and swapping.

Fluidized bed desulfurization

NASA Technical Reports Server (NTRS)

Ravindram, M.; Kallvinskas, J. J. (Inventor)

1985-01-01

High sulfur content carbonaceous material, such as coal is desulfurized by continuous fluidized suspension in a reactor with chlorine gas, inert dechlorinating gas and hydrogen gas. A source of chlorine gas, a source of inert gas and a source of hydrogen gas are connected to the bottom inlet through a manifold and a heater. A flow controler operates servos in a manner to continuously and sequentially suspend coal in the three gases. The sulfur content is reduced at least 50% by the treatment.

Detonation wave detection probe including parallel electrodes on a flexible backing strip

DOEpatents

Uher, Kenneth J.

1995-01-01

A device for sensing the occurrence of destructive events and events involving mechanical shock in a non-intrusive manner. A pair of electrodes is disposed in a parallel configuration on a backing strip of flexible film. Electrical circuitry is used to sense the time at which an event causes electrical continuity between the electrodes or, with a sensor configuration where the electrodes are shorted together, to sense the time at which electrical continuity is lost.

A Computer Program to Model Passive Acoustic Antisubmarine Search Using Monte Carlo Simulation Techniques.

DTIC Science & Technology

1983-09-01

duplicate a continuous function on a digital computer, and thus the machine representatic- of the GMA is only a close approximation of the continuous...error process. Thus, the manner in which the GMA process is digitally replicated has an effect on the results of the simulation. The parameterization of...Information Center 2 Cameron Station Alexandria, Virginia 22314 2. Libary , Code 0142 2 Naval Postgraduate School Monterey, California 93943 3. Professor

New method of feeding coal - Continuous extrusion of fully plastic coal

NASA Technical Reports Server (NTRS)

Ryason, P. R.; England, C.

1978-01-01

Continuous feeding of coal in a compressing screw extruder is described as a method of introducing coal into pressurized systems. The method utilizes the property of many bituminous coals of softening at temperatures from 350 to 400 C. Coal is then fed much in the manner of common thermoplastics, using screw extruders. Preliminary results show that coals can be extruded at rates of about 3.3 kg/MJ, similar to those for plastics.

System Applies Polymer Powder To Filament Tow

NASA Technical Reports Server (NTRS)

Baucom, Robert M.; Snoha, John J.; Marchello, Joseph M.

1993-01-01

Polymer powder applied uniformly and in continuous manner. Powder-coating system applies dry polymer powder to continuous fiber tow. Unique filament-spreading technique, combined with precise control of tension on fibers in system, ensures uniform application of polymer powder to web of spread filaments. Fiber tows impregnated with dry polymer powders ("towpregs") produced for preform-weaving and composite-material-molding applications. System and process valuable to prepreg industry, for production of flexible filament-windable tows and high-temperature polymer prepregs.

Rapid protein concentration, efficient fluorescence labeling and purification on a micro/nanofluidics chip.

PubMed

Wang, Chen; Ouyang, Jun; Ye, De-Kai; Xu, Jing-Juan; Chen, Hong-Yuan; Xia, Xing-Hua

2012-08-07

Fluorescence analysis has proved to be a powerful detection technique for achieving single molecule analysis. However, it usually requires the labeling of targets with bright fluorescent tags since most chemicals and biomolecules lack fluorescence. Conventional fluorescence labeling methods require a considerable quantity of biomolecule samples, long reaction times and extensive chromatographic purification procedures. Herein, a micro/nanofluidics device integrating a nanochannel in a microfluidics chip has been designed and fabricated, which achieves rapid protein concentration, fluorescence labeling, and efficient purification of product in a miniaturized and continuous manner. As a demonstration, labeling of the proteins bovine serum albumin (BSA) and IgG with fluorescein isothiocyanate (FITC) is presented. Compared to conventional methods, the present micro/nanofluidics device performs about 10(4)-10(6) times faster BSA labeling with 1.6 times higher yields due to the efficient nanoconfinement effect, improved mass, and heat transfer in the chip device. The results demonstrate that the present micro/nanofluidics device promises rapid and facile fluorescence labeling of small amount of reagents such as proteins, nucleic acids and other biomolecules with high efficiency.

A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making.

PubMed

Jain, Roshan A; Wolman, Marc A; Marsden, Kurt C; Nelson, Jessica C; Shoenhard, Hannah; Echeverry, Fabio A; Szi, Christina; Bell, Hannah; Skinner, Julianne; Cobbs, Emilia N; Sawada, Keisuke; Zamora, Amy D; Pereda, Alberto E; Granato, Michael

2018-05-07

Animals continuously integrate sensory information and select contextually appropriate responses. Here, we show that zebrafish larvae select a behavioral response to acoustic stimuli from a pre-existing choice repertoire in a context-dependent manner. We demonstrate that this sensorimotor choice is modulated by stimulus quality and history, as well as by neuromodulatory systems-all hallmarks of more complex decision making. Moreover, from a genetic screen coupled with whole-genome sequencing, we identified eight mutants with deficits in this sensorimotor choice, including mutants of the vertebrate-specific G-protein-coupled extracellular calcium-sensing receptor (CaSR), whose function in the nervous system is not well understood. We demonstrate that CaSR promotes sensorimotor decision making acutely through Gα i/o and Gα q/11 signaling, modulated by clathrin-mediated endocytosis. Combined, our results identify the first set of genes critical for behavioral choice modulation in a vertebrate and reveal an unexpected critical role for CaSR in sensorimotor decision making. Copyright © 2018 Elsevier Ltd. All rights reserved.

An Efficient Taguchi Approach for the Performance Optimization of Health, Safety, Environment and Ergonomics in Generation Companies

PubMed Central

Azadeh, Ali; Sheikhalishahi, Mohammad

2014-01-01

Background A unique framework for performance optimization of generation companies (GENCOs) based on health, safety, environment, and ergonomics (HSEE) indicators is presented. Methods To rank this sector of industry, the combination of data envelopment analysis (DEA), principal component analysis (PCA), and Taguchi are used for all branches of GENCOs. These methods are applied in an integrated manner to measure the performance of GENCO. The preferred model between DEA, PCA, and Taguchi is selected based on sensitivity analysis and maximum correlation between rankings. To achieve the stated objectives, noise is introduced into input data. Results The results show that Taguchi outperforms other methods. Moreover, a comprehensive experiment is carried out to identify the most influential factor for ranking GENCOs. Conclusion The approach developed in this study could be used for continuous assessment and improvement of GENCO's performance in supplying energy with respect to HSEE factors. The results of such studies would help managers to have better understanding of weak and strong points in terms of HSEE factors. PMID:26106505

Characterization of Pilot Technique

NASA Technical Reports Server (NTRS)

Bachelder, Edward; Aponso, Bimal; Godfroy, Martine

2017-01-01

Skilled pilots often use pulse control when controlling higher order (i.e. acceleration-command) vehicle dynamics. Pulsing does not produce a stick response that resembles what the human Crossover Model predicts. The Crossover Model (CM) assumes the pilot provides compensation necessary (lead or lag) such that the suite of display-human-vehicle approximates an integrator in the region of crossover frequency. However, it is shown that the CM does appear to drive the pilots pulsing behavior in a very predictable manner. Roughly speaking, the pilot generates pulses such that the area under the pulse (pulse amplitude multiplied by pulse width) is approximately equal to area under the hypothetical CM output. This can allow a pilot to employ constant amplitude pulsing so that only the pulse duration (width) is modulated a drastic simplification over the demands of continuous tracking. A pilot pulse model is developed, with which the parameters of the pilots internally-generated CM can be computed in real time for pilot monitoring and display compensation. It is also demonstrated that pursuit tracking may be activated when pulse control is employed.

Genome-wide regression and prediction with the BGLR statistical package.

PubMed

Pérez, Paulino; de los Campos, Gustavo

2014-10-01

Many modern genomic data analyses require implementing regressions where the number of parameters (p, e.g., the number of marker effects) exceeds sample size (n). Implementing these large-p-with-small-n regressions poses several statistical and computational challenges, some of which can be confronted using Bayesian methods. This approach allows integrating various parametric and nonparametric shrinkage and variable selection procedures in a unified and consistent manner. The BGLR R-package implements a large collection of Bayesian regression models, including parametric variable selection and shrinkage methods and semiparametric procedures (Bayesian reproducing kernel Hilbert spaces regressions, RKHS). The software was originally developed for genomic applications; however, the methods implemented are useful for many nongenomic applications as well. The response can be continuous (censored or not) or categorical (either binary or ordinal). The algorithm is based on a Gibbs sampler with scalar updates and the implementation takes advantage of efficient compiled C and Fortran routines. In this article we describe the methods implemented in BGLR, present examples of the use of the package, and discuss practical issues emerging in real-data analysis. Copyright © 2014 by the Genetics Society of America.

Medical Informatics Education & Research in Greece.

PubMed

Chouvarda, I; Maglaveras, N

2015-08-13

This paper aims to present an overview of the medical informatics landscape in Greece, to describe the Greek ehealth background and to highlight the main education and research axes in medical informatics, along with activities, achievements and pitfalls. With respect to research and education, formal and informal sources were investigated and information was collected and presented in a qualitative manner, including also quantitative indicators when possible. Greece has adopted and applied medical informatics education in various ways, including undergraduate courses in health sciences schools as well as multidisciplinary postgraduate courses. There is a continuous research effort, and large participation in EU-wide initiatives, in all the spectrum of medical informatics research, with notable scientific contributions, although technology maturation is not without barriers. Wide-scale deployment of eHealth is anticipated in the healthcare system in the near future. While ePrescription deployment has been an important step, ICT for integrated care and telehealth have a lot of room for further deployment. Greece is a valuable contributor in the European medical informatics arena, and has the potential to offer more as long as the barriers of research and innovation fragmentation are addressed and alleviated.

Large Area 2D and 3D Colloidal Photonic Crystals Fabricated by a Roll-to-Roll Langmuir-Blodgett Method.

PubMed

Parchine, Mikhail; McGrath, Joe; Bardosova, Maria; Pemble, Martyn E

2016-06-14

We present our results on the fabrication of large area colloidal photonic crystals on flexible poly(ethylene terephthalate) (PET) film using a roll-to-roll Langmuir-Blodgett technique. Two-dimensional (2D) and three-dimensional (3D) colloidal photonic crystals from silica nanospheres (250 and 550 nm diameter) with a total area of up to 340 cm(2) have been fabricated in a continuous manner compatible with high volume manufacturing. In addition, the antireflective properties and structural integrity of the films have been enhanced via the use of a second roll-to-roll process, employing a slot-die coating of an optical adhesive over the photonic crystal films. Scanning electron microscopy images, atomic force microscopy images, and UV-vis optical transmission and reflection spectra of the fabricated photonic crystals are analyzed. This analysis confirms the high quality of the 2D and 3D photonic crystals fabricated by the roll-to-roll LB technique. Potential device applications of the large area 2D and 3D colloidal photonic crystals on flexible PET film are briefly reviewed.

Accurate path integration in continuous attractor network models of grid cells.

PubMed

Burak, Yoram; Fiete, Ila R

2009-02-01

Grid cells in the rat entorhinal cortex display strikingly regular firing responses to the animal's position in 2-D space and have been hypothesized to form the neural substrate for dead-reckoning. However, errors accumulate rapidly when velocity inputs are integrated in existing models of grid cell activity. To produce grid-cell-like responses, these models would require frequent resets triggered by external sensory cues. Such inadequacies, shared by various models, cast doubt on the dead-reckoning potential of the grid cell system. Here we focus on the question of accurate path integration, specifically in continuous attractor models of grid cell activity. We show, in contrast to previous models, that continuous attractor models can generate regular triangular grid responses, based on inputs that encode only the rat's velocity and heading direction. We consider the role of the network boundary in the integration performance of the network and show that both periodic and aperiodic networks are capable of accurate path integration, despite important differences in their attractor manifolds. We quantify the rate at which errors in the velocity integration accumulate as a function of network size and intrinsic noise within the network. With a plausible range of parameters and the inclusion of spike variability, our model networks can accurately integrate velocity inputs over a maximum of approximately 10-100 meters and approximately 1-10 minutes. These findings form a proof-of-concept that continuous attractor dynamics may underlie velocity integration in the dorsolateral medial entorhinal cortex. The simulations also generate pertinent upper bounds on the accuracy of integration that may be achieved by continuous attractor dynamics in the grid cell network. We suggest experiments to test the continuous attractor model and differentiate it from models in which single cells establish their responses independently of each other.

Open pre-schools at integrated health services-A program theory.

PubMed

Abrahamsson, Agneta; Samarasinghe, Kerstin

2013-04-01

Family centres in Sweden are integrated services that reach all prospective parents and parents with children up to their sixth year, because of the co-location of the health service with the social service and the open pre-school. The personnel on the multi-professional site work together to meet the needs of the target group. The article explores a program theory focused on the open pre-schools at family centres. A multi-case design is used and the sample consists of open pre-schools at six family centres. The hypothesis is based on previous research and evaluation data. It guides the data collection which is collected and analysed stepwise. Both parents and personnel are interviewed individually and in groups at each centre. The hypothesis was expanded to a program theory. The compliance of the professionals was the most significant element that explained why the open access service facilitated positive parenting. The professionals act in a compliant manner to meet the needs of the children and parents as well as in creating good conditions for social networking and learning amongst the parents. The compliance of the professionals in this program theory of open pre-schools at family centres can be a standard in integrated and open access services, whereas the organisation form can vary. The best way of increasing the number of integrative services is to support and encourage professionals that prefer to work in a compliant manner.

The interactions of multisensory integration with endogenous and exogenous attention

PubMed Central

Tang, Xiaoyu; Wu, Jinglong; Shen, Yong

2016-01-01

Stimuli from multiple sensory organs can be integrated into a coherent representation through multiple phases of multisensory processing; this phenomenon is called multisensory integration. Multisensory integration can interact with attention. Here, we propose a framework in which attention modulates multisensory processing in both endogenous (goal-driven) and exogenous (stimulus-driven) ways. Moreover, multisensory integration exerts not only bottom-up but also top-down control over attention. Specifically, we propose the following: (1) endogenous attentional selectivity acts on multiple levels of multisensory processing to determine the extent to which simultaneous stimuli from different modalities can be integrated; (2) integrated multisensory events exert top-down control on attentional capture via multisensory search templates that are stored in the brain; (3) integrated multisensory events can capture attention efficiently, even in quite complex circumstances, due to their increased salience compared to unimodal events and can thus improve search accuracy; and (4) within a multisensory object, endogenous attention can spread from one modality to another in an exogenous manner. PMID:26546734

The interactions of multisensory integration with endogenous and exogenous attention.

PubMed

Tang, Xiaoyu; Wu, Jinglong; Shen, Yong

2016-02-01

Stimuli from multiple sensory organs can be integrated into a coherent representation through multiple phases of multisensory processing; this phenomenon is called multisensory integration. Multisensory integration can interact with attention. Here, we propose a framework in which attention modulates multisensory processing in both endogenous (goal-driven) and exogenous (stimulus-driven) ways. Moreover, multisensory integration exerts not only bottom-up but also top-down control over attention. Specifically, we propose the following: (1) endogenous attentional selectivity acts on multiple levels of multisensory processing to determine the extent to which simultaneous stimuli from different modalities can be integrated; (2) integrated multisensory events exert top-down control on attentional capture via multisensory search templates that are stored in the brain; (3) integrated multisensory events can capture attention efficiently, even in quite complex circumstances, due to their increased salience compared to unimodal events and can thus improve search accuracy; and (4) within a multisensory object, endogenous attention can spread from one modality to another in an exogenous manner. Copyright © 2015 Elsevier Ltd. All rights reserved.

The One Human Problem, Its Solution, and Its Relation to UFO Phenomen

DTIC Science & Technology

1977-01-01

spirit, stages of evolution, technological species, telepathy , time, tobiscope, tulpa, ultraviolet, unidentified flying objects. Block20. (Continued...manner undreamed of in his present wildest imagination. And indeed there are stranger things in ultimate reality than are dreamed of in our

Fusion Teaching: Utilizing Course Management Technology to Deliver an Effective Multimodal Pedagogy

ERIC Educational Resources Information Center

Childs, Bradley D.; Cochran, Howard H.; Velikova, Marieta

2013-01-01

Fusion teaching merges several pedagogies into a coherent whole. Course management technology allows for the digitization and delivery of pedagogies in an effective and exciting manner. Online course management options more easily enable outcome assessment and monitoring for continuous improvement.

76 FR 61365 - Bundled Payments for Care Improvement Initiative

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-04

..., better health care, and reduced expenditures through continuous improvement for Medicare, Medicaid and... and patient experience when health care providers work in a coordinated and patient-centered manner... initiative. This initiative seeks proposals from health care providers who wish to align incentives between...

47 CFR 95.406 - (CB Rule 6) Are there any special restrictions on the location of my CB station?

Code of Federal Regulations, 2011 CFR

2011-10-01

... COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Citizens Band (CB) Radio... operated in such a manner as to raise environmental problems, under § 1.1307 of this chapter, you must...

47 CFR 95.406 - (CB Rule 6) Are there any special restrictions on the location of my CB station?

Code of Federal Regulations, 2010 CFR

2010-10-01

... COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Citizens Band (CB) Radio... operated in such a manner as to raise environmental problems, under § 1.1307 of this chapter, you must...

7 CFR 550.30 - Advertising.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Advertising. 550.30 Section 550.30 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF... Program Management § 550.30 Advertising. The Cooperator will not refer in any manner to the USDA or...

7 CFR 550.30 - Advertising.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Advertising. 550.30 Section 550.30 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF... Program Management § 550.30 Advertising. The Cooperator will not refer in any manner to the USDA or...

7 CFR 550.30 - Advertising.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Advertising. 550.30 Section 550.30 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF... Program Management § 550.30 Advertising. The Cooperator will not refer in any manner to the USDA or...

7 CFR 550.30 - Advertising.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Advertising. 550.30 Section 550.30 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF... Program Management § 550.30 Advertising. The Cooperator will not refer in any manner to the USDA or...

7 CFR 550.30 - Advertising.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Advertising. 550.30 Section 550.30 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF... Program Management § 550.30 Advertising. The Cooperator will not refer in any manner to the USDA or...

40 CFR 721.3085 - Brominated phthalate ester.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information, and any information on methods for protecting against such risk, into a MSDS as described in... Section 721.3085 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... substance is any manner or method of manufacture, import, or processing associated with any use of these...

40 CFR 721.3880 - Polyalkylene glycol substituted acetate.

Code of Federal Regulations, 2010 CFR

2010-07-01

... acetate. 721.3880 Section 721.3880 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... communication program. A significant new use of this substance is any manner or method of manufacture, import, or processing associated with any use of this substance without providing risk notification as...

40 CFR 721.3629 - Triethanolamine salts of fatty acids.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... 721.3629 Section 721.3629 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC...) Hazard communication program. A significant new use of these substances is any manner or method of manufacture, import, or processing associated with any use of these substances without providing risk...

40 CFR 721.3815 - Furan, 2-(ethoxymethyl)- tetrahydro-.

Code of Federal Regulations, 2010 CFR

2010-07-01

... new information, and any information on methods for protecting against such risk, into a Material...-. 721.3815 Section 721.3815 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 721.4620 - Dialkylamino alkanoate metal salt.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this new information, and any information on methods for protecting against such risk, into a Material....4620 Section 721.4620 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... significant new use of this substance is any manner or method of manufacture, import, or processing associated...

40 CFR 721.4600 - Recovered metal hydroxide.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this new information, and any information on methods for protecting against such risk, into an MSDS as... Section 721.4600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... new use of this substance is any manner or method of manufacture, import, or processing associated...

40 CFR 721.6060 - Alkylaryl substituted phosphite.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this new information, and any information on methods for protecting against such risk, into an MSDS as....6060 Section 721.6060 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... significant new use of this substance is any manner or method of manufacture, import, or processing associated...

50 CFR 36.42 - Public participation and closure procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM ALASKA NATIONAL WILDLIFE REFUGES Permits... protection, protection of cultural or scientific values, subsistence uses, endangered or threatened species... managed in a manner compatible with the purposes for which the Alaska National Wildlife Refuge area was...

50 CFR 36.42 - Public participation and closure procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM ALASKA NATIONAL WILDLIFE REFUGES Permits... protection, protection of cultural or scientific values, subsistence uses, endangered or threatened species... managed in a manner compatible with the purposes for which the Alaska National Wildlife Refuge area was...

40 CFR 170.103 - Exceptions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Exceptions. 170.103 Section 170.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION... squirt,” “frill and spray,” chemigation, soil-incorporation, or soil-injection; (f) In a manner not...

4 CFR 7.2 - Equal employment opportunity.

Code of Federal Regulations, 2011 CFR

2011-01-01

... eliminating minority and women underrepresentation. (c) Statutory rights and remedies. Nothing in this order... continuing programs for the recruitment of members of minorities and women for positions in GAO in a manner designed to eliminate underrepresentation of minorities and women in the various categories of employment...

4 CFR 7.2 - Equal employment opportunity.

Code of Federal Regulations, 2010 CFR

2010-01-01

... eliminating minority and women underrepresentation. (c) Statutory rights and remedies. Nothing in this order... continuing programs for the recruitment of members of minorities and women for positions in GAO in a manner designed to eliminate underrepresentation of minorities and women in the various categories of employment...

4 CFR 7.2 - Equal employment opportunity.

Code of Federal Regulations, 2014 CFR

2014-01-01

... eliminating minority and women underrepresentation. (c) Statutory rights and remedies. Nothing in this order... continuing programs for the recruitment of members of minorities and women for positions in GAO in a manner designed to eliminate underrepresentation of minorities and women in the various categories of employment...

4 CFR 7.2 - Equal employment opportunity.

Code of Federal Regulations, 2012 CFR

2012-01-01

... eliminating minority and women underrepresentation. (c) Statutory rights and remedies. Nothing in this order... continuing programs for the recruitment of members of minorities and women for positions in GAO in a manner designed to eliminate underrepresentation of minorities and women in the various categories of employment...

4 CFR 7.2 - Equal employment opportunity.

Code of Federal Regulations, 2013 CFR

2013-01-01

... eliminating minority and women underrepresentation. (c) Statutory rights and remedies. Nothing in this order... continuing programs for the recruitment of members of minorities and women for positions in GAO in a manner designed to eliminate underrepresentation of minorities and women in the various categories of employment...

40 CFR 240.208-2 - Recommended procedures: Design.

Code of Federal Regulations, 2010 CFR

2010-07-01

....208-2 Section 240.208-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures... allow for removal from the site of residue or other solids in a manner that protects the environment. ...

29 CFR 1902.37 - Factors for determination.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... timely developed and promulgated standards which are at least as effective as the comparable Federal... interpreted and applied in a manner which is at least as effective as the interpretation and application of...

49 CFR 579.29 - Manner of reporting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) REPORTING OF INFORMATION AND COMMUNICATIONS ABOUT... through 579.26 of this part may be submitted in digital form using a graphic compression protocol...) Graphic compression protocol. Not later than 30 days prior to the date of its first quarterly submission...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bragg-Sitton, Shannon; Boardman, Richard; Ruth, Mark

The U.S. Department of Energy (DOE) recognizes the need to transform the energy infrastructure of the U.S. and elsewhere to systems that can drastically reduce environmental impacts in an efficient and economically viable manner while utilizing both hydrocarbon resources and clean energy generation sources. Thus, DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options. A concept being advanced by the DOE Offices of Nuclear Energy (NE) and Energy Efficiency and Renewable Energy (EERE) is tighter coupling of nuclear and renewable energy sources in a manner thatmore » produces new energy currency for the combined electricity grid, industrial manufacturing, and the transportation energy sectors. This integration concept has been referred to as a “hybrid system” that is capable of providing the right type of energy, at the right time, in the right place. At the direction of DOE-NE and DOE-EERE leadership, project leads at Idaho National Laboratory (INL), National Renewable Energy Laboratory (NREL) and Massachusetts Institute of Technology (MIT) have identified and engaged stakeholders in discussing integrated energy systems that would optimize renewable and nuclear energy integration on a region-by-region basis. Subsequent work will entail conduct of technical, economic, environmental and socio-political evaluations of the leading integrated system options based on a set of criteria established with stakeholder input. The Foundational Workshop for Integrated Nuclear – Renewable Energy Systems was organized around the following objectives: 1. Identify and refine priority region-specific opportunities for integrated nuclear-renewable energy systems in the U.S.; 2. Select Figures of Merit (FOM) to rank and prioritize candidate systems; 3. Discuss enabling technology development needs; 4. Identify analysis requirements, capabilities and gaps to estimate FOM for integrated system options; 5. Identify experimental needs to develop and demonstrate nuclear-renewable energy systems.« less

Human Systems Integration in the Federal Government

NASA Technical Reports Server (NTRS)

Jones, Patricia M.; Graves, Gaye L.; Allard, Terry; Blackhurst, Jack; Fitts, David J.; Peters, Sean; Piccione, Dino; Shattuck, Lawrence G.

2010-01-01

Human Systems Integration principles and methods can be used to help integrate people, technology, and organizations in an effective and efficient manner. Over the past decade, a wide range of tools, techniques, and technologies have been developed by federal agencies to achieve significant cost and performance benefits. In this discussion, we will explore trends in military human systems integration and learn about the critical role being played by human performance and effectiveness research. We will also examine case studies on the planning and design of future human space flight vehicles, the national air space system and the first nuclear reactors to be built in the United States in over 30 years. And with an eye toward sustaining the discipline s principles and methods, we ll take a look at educating and training the next generation of human systems integration practitioners.

Specific and Individuated Death Reflection Fosters Identity Integration

PubMed Central

Cozzolino, Philip J.; Sedikides, Constantine

2016-01-01

Identity integration is the process wherein a person assimilates multiple or conflicting identities (e.g., beliefs, values, needs) into a coherent, unified self-concept. Three experiments examined whether contemplating mortality in a specific and individuated manner (i.e., via the death reflection manipulation) facilitated outcomes indicative of identity integration. Participants in the death reflection condition (vs. control conditions) considered positive and negative life experiences as equally important in shaping their current identity (Experiment 1), regarded self-serving values and other-serving values as equally important life principles (Experiment 2), and were equally motivated to pursue growth-oriented and security-oriented needs (Experiment 3). Death reflection motivates individuals to integrate conflicting aspects of their identity into a coherent self-concept. Given that identity integration is associated with higher well-being, the findings have implications for understanding the psychological benefits of existential contemplation. PMID:27152863

Dissociable cognitive mechanisms underlying human path integration.

PubMed

Wiener, Jan M; Berthoz, Alain; Wolbers, Thomas

2011-01-01

Path integration is a fundamental mechanism of spatial navigation. In non-human species, it is assumed to be an online process in which a homing vector is updated continuously during an outward journey. In contrast, human path integration has been conceptualized as a configural process in which travelers store working memory representations of path segments, with the computation of a homing vector only occurring when required. To resolve this apparent discrepancy, we tested whether humans can employ different path integration strategies in the same task. Using a triangle completion paradigm, participants were instructed either to continuously update the start position during locomotion (continuous strategy) or to remember the shape of the outbound path and to calculate home vectors on basis of this representation (configural strategy). While overall homing accuracy was superior in the configural condition, participants were quicker to respond during continuous updating, strongly suggesting that homing vectors were computed online. Corroborating these findings, we observed reliable differences in head orientation during the outbound path: when participants applied the continuous updating strategy, the head deviated significantly from straight ahead in direction of the start place, which can be interpreted as a continuous motor expression of the homing vector. Head orientation-a novel online measure for path integration-can thus inform about the underlying updating mechanism already during locomotion. In addition to demonstrating that humans can employ different cognitive strategies during path integration, our two-systems view helps to resolve recent controversies regarding the role of the medial temporal lobe in human path integration.

Access to Interprofessional Continuing Education in Integrated Care through Digital Instructional Technology

ERIC Educational Resources Information Center

Lapidos, Adrienne; Ruffolo, Mary

2017-01-01

In preparing the workforce for integrated care, continuing professional education serves a critical role. Within a rapidly changing health care landscape, matriculated students now benefit from pedagogical innovations supporting integrated care, particularly interprofessional education, and working professionals must not be excluded from this…

49 CFR 192.909 - How can an operator change its integrity management program?

Code of Federal Regulations, 2010 CFR

2010-10-01

... (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Gas Transmission Pipeline Integrity Management § 192.909 How can an operator change its integrity management...

Evolving the Principles and Practice of Validation for New Alternative Approaches to Toxicity Testing.

PubMed

Whelan, Maurice; Eskes, Chantra

Validation is essential for the translation of newly developed alternative approaches to animal testing into tools and solutions suitable for regulatory applications. Formal approaches to validation have emerged over the past 20 years or so and although they have helped greatly to progress the field, it is essential that the principles and practice underpinning validation continue to evolve to keep pace with scientific progress. The modular approach to validation should be exploited to encourage more innovation and flexibility in study design and to increase efficiency in filling data gaps. With the focus now on integrated approaches to testing and assessment that are based on toxicological knowledge captured as adverse outcome pathways, and which incorporate the latest in vitro and computational methods, validation needs to adapt to ensure it adds value rather than hinders progress. Validation needs to be pursued both at the method level, to characterise the performance of in vitro methods in relation their ability to detect any association of a chemical with a particular pathway or key toxicological event, and at the methodological level, to assess how integrated approaches can predict toxicological endpoints relevant for regulatory decision making. To facilitate this, more emphasis needs to be given to the development of performance standards that can be applied to classes of methods and integrated approaches that provide similar information. Moreover, the challenge of selecting the right reference chemicals to support validation needs to be addressed more systematically, consistently and in a manner that better reflects the state of the science. Above all however, validation requires true partnership between the development and user communities of alternative methods and the appropriate investment of resources.

47 CFR 68.354 - Numbering and labeling requirements for terminal equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Conformity or that is certified by a Telecommunications Certification Body shall have labels in a place and manner required by the Administrative Council for Terminal Attachments. (b) Terminal equipment labels... Terminal Attachments. (c) If the Administrative Council for Terminal Attachments chooses to continue the...

49 CFR 179.10 - Tank mounting.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Tank mounting. 179.10 Section 179.10... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS General Design Requirements § 179.10 Tank mounting. (a) The manner in which tanks are attached to the car structure shall be...

49 CFR 179.10 - Tank mounting.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Tank mounting. 179.10 Section 179.10... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS General Design Requirements § 179.10 Tank mounting. (a) The manner in which tanks are attached to the car structure shall be...

49 CFR 179.10 - Tank mounting.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Tank mounting. 179.10 Section 179.10... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS General Design Requirements § 179.10 Tank mounting. (a) The manner in which tanks are attached to the car structure shall be...

49 CFR 179.10 - Tank mounting.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Tank mounting. 179.10 Section 179.10... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS General Design Requirements § 179.10 Tank mounting. (a) The manner in which tanks are attached to the car structure shall be...

47 CFR 87.43 - Operation during emergency.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES AVIATION SERVICES Applications and Licenses § 87.43 Operation during emergency. A station may be used for emergency communications in a manner other than that specified in the station license or in the operating rules when normal...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

"Arribismo".

ERIC Educational Resources Information Center

Bennis, Warren

1970-01-01

The student revolution has become the dominant instrument of social change in this country and will continue to be. Society is at the moment in an intrusion-activism phase with invisible disturbances surfacing, generally in a violent manner. An amorphous counter-culture is emerging, a person-centered culture that is challenging the scarcity and…

40 CFR 721.5800 - Sulfurized alkylphenol.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information on methods for protecting against such risk, into an MSDS as described in § 721.72(c) within 90... Section 721.5800 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 721.5450 - α-Olefin sulfonate, sodium salt.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this new information, and any information on methods for protecting against such risk, into an MSDS as....5450 Section 721.5450 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... significant new use of this substance is any manner or method of manufacture, import, or processing associated...

40 CFR 721.5546 - Halogen substituted oxetanes (generic).

Code of Federal Regulations, 2010 CFR

2010-07-01

..., and any information on methods for protecting against such risk, into a Material Safety Data Sheet...). 721.5546 Section 721.5546 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... program. A significant new use of these chemical substances is any manner or method of manufacture, import...

40 CFR 721.3860 - Glycol monobenzoate.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information on methods for protecting against such risk, into an MSDS as described in § 721.72(c) within 90... 721.3860 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 721.5980 - Dialkyl phosphorodithioate phosphate compounds.

Code of Federal Regulations, 2010 CFR

2010-07-01

... any information on methods for protecting against such risk, into an MSDS as described at § 721.72(c... compounds. 721.5980 Section 721.5980 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... manner or method of manufacture, import, or processing associated with any use of these substances...

24 CFR 232.885 - Insurance benefits.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Insurance benefits. 232.885 Section 232.885 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued....885 Insurance benefits. (a) Method of payment. Payment of claim shall be made in the following manner...

24 CFR 232.885 - Insurance benefits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance benefits. 232.885 Section 232.885 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued....885 Insurance benefits. (a) Method of payment. Payment of claim shall be made in the following manner...

24 CFR 232.885 - Insurance benefits.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Insurance benefits. 232.885 Section 232.885 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued....885 Insurance benefits. (a) Method of payment. Payment of claim shall be made in the following manner...

24 CFR 232.885 - Insurance benefits.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Insurance benefits. 232.885 Section 232.885 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued....885 Insurance benefits. (a) Method of payment. Payment of claim shall be made in the following manner...

24 CFR 232.885 - Insurance benefits.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Insurance benefits. 232.885 Section 232.885 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued....885 Insurance benefits. (a) Method of payment. Payment of claim shall be made in the following manner...

7 CFR 1780.14 - Security.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Security. 1780.14 Section 1780.14 Agriculture... (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.14 Security. Loans will be secured by the best security position practicable in a manner which will adequately protect the...

7 CFR 1780.14 - Security.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 12 2011-01-01 2011-01-01 false Security. 1780.14 Section 1780.14 Agriculture... (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.14 Security. Loans will be secured by the best security position practicable in a manner which will adequately protect the...

7 CFR 1780.14 - Security.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 12 2012-01-01 2012-01-01 false Security. 1780.14 Section 1780.14 Agriculture... (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.14 Security. Loans will be secured by the best security position practicable in a manner which will adequately protect the...

7 CFR 1780.14 - Security.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 12 2013-01-01 2013-01-01 false Security. 1780.14 Section 1780.14 Agriculture... (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.14 Security. Loans will be secured by the best security position practicable in a manner which will adequately protect the...

7 CFR 1780.14 - Security.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 12 2014-01-01 2013-01-01 true Security. 1780.14 Section 1780.14 Agriculture... (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.14 Security. Loans will be secured by the best security position practicable in a manner which will adequately protect the...

7 CFR 1210.362 - Influencing government action.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Influencing government action. 1210.362 Section 1210.362 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... government action. No funds received by the Board under this Plan shall in any manner be used for the purpose...

Enforcing prompt-payment regulations: the Texas approach.

PubMed

McCoy, Jim E; Han, Michael C; Malloy, Michael S

2002-07-01

To ensure that insurance carriers pay providers in a timely manner, Texas has adopted strict payment regulations. Enforcement of the regulations has led to restitution payments for many providers. However, issues such as clean claims, underpayment, discrepancies in payment dates, and self-funded claims continue to present challenges.

21 CFR 640.81 - Processing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Processing. 640.81 Section 640.81 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS ADDITIONAL...) Microbial contamination. All processing steps shall be conducted in a manner to minimize the risk of...

21 CFR 640.91 - Processing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Processing. 640.91 Section 640.91 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) BIOLOGICS ADDITIONAL... intravenous injection. (c) Microbial contamination. All processing steps shall be conducted in a manner to...

45 CFR 674.7 - Exception for serendipitous finds.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Exception for serendipitous finds. 674.7 Section 674.7 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... meteorite for scientific research purposes, provided that the meteorite is collected in the manner most...

40 CFR 303.30 - Criteria for payment of award.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Criteria for payment of award. 303.30 Section 303.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... have obtained knowledge of the violation in a timely manner absent claimant's information; (c...

Tracking costs of alternatively fueled buses in Florida - phase II.

DOT National Transportation Integrated Search

2013-04-01

The goal of this project is to continue collecting and reporting the data on the performance and costs of alternatively fueled public transit vehicles in the state in a consistent manner in order to keep the Bus Fuels Fleet Evaluation Tool (BuFFeT) c...

Climate change; Confronting the global experiment

Treesearch

Constance I. Millar

2006-01-01

Earth’s natural climate system is characterized by continually changing climates, with climate regimes that oscillate quasi-cyclically at multiple and nested scales from annual to multi-millennial, and commonly change abruptly. Under naturally changing climates, plant species track changes at all scales in individualistic manner, with plant communities...

Detonation wave detection probe including parallel electrodes on a flexible backing strip

DOEpatents

Uher, K.J.

1995-12-19

A device is disclosed for sensing the occurrence of destructive events and events involving mechanical shock in a non-intrusive manner. A pair of electrodes is disposed in a parallel configuration on a backing strip of flexible film. Electrical circuitry is used to sense the time at which an event causes electrical continuity between the electrodes or, with a sensor configuration where the electrodes are shorted together, to sense the time at which electrical continuity is lost. 4 figs.

Volcanic investigations in the Commonwealth of the Northern Mariana Islands, April to May 1994

USGS Publications Warehouse

Sako, M.K.; Trusdell, F.A.; Koyanagi, R.Y.; Kojima, George; Moore, R.B.

1995-01-01

We conclude that the low and infrequent shallow seismicity, lack of significant deformation, and low fumarole temperatures suggest that no eruption is likely soon on Agrihan and Alamagan. Anatahan's deformation pattern continues to behave in an erratic manner. Because f the lack of seismicity, it seems unlikely that an eruption of Anatahan will occur soon. The persistent volcanic tremor and significant EDM changes on Mount Pagan mean that small explosive eruptions will continue to occur.

[Application of biotope mapping model integrated with vegetation cover continuity attributes in urban biodiversity conservation].

PubMed

Gao, Tian; Qiu, Ling; Chen, Cun-gen

2010-09-01

Based on the biotope classification system with vegetation structure as the framework, a modified biotope mapping model integrated with vegetation cover continuity attributes was developed, and applied to the study of the greenbelts in Helsingborg in southern Sweden. An evaluation of the vegetation cover continuity in the greenbelts was carried out by the comparisons of the vascular plant species richness in long- and short-continuity forests, based on the identification of woodland continuity by using ancient woodland indicator species (AWIS). In the test greenbelts, long-continuity woodlands had more AWIS. Among the forests where the dominant trees were more than 30-year-old, the long-continuity ones had a higher biodiversity of vascular plants, compared with the short-continuity ones with the similar vegetation structure. The modified biotope mapping model integrated with the continuity features of vegetation cover could be an important tool in investigating urban biodiversity, and provide corresponding strategies for future urban biodiversity conservation.

Colonization and effector functions of innate lymphoid cells in mucosal tissues.

PubMed

Kim, Myunghoo; Kim, Chang H

2016-10-01

Innate lymphoid cells (ILCs) protect mucosal barrier tissues to fight infection and maintain tissue integrity. ILCs and their progenitors are developmentally programmed to migrate, differentiate and populate various mucosal tissues and associated lymphoid tissues. Functionally mature ILC subsets respond to diverse pathogens such as bacteria, viruses, fungi and parasites in subset-specific manners. In this review, we will discuss how ILCs populate mucosal tissues and regulate immune responses to distinct pathogens to protect the host and maintain tissue integrity. Copyright © 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

[We are sexual beings. Sexuality/reproduction pattern. An evaluation and the implications for nurses in the mental health field].

PubMed

Lobán Iza, José Manuel

2006-05-01

The author pretends to integrate the double-sided aspects of nursing care in the mental health field with the specific attention each individual needs as a sexual being, since this is an intrinsic factor of human beings. The World Health Organization defines sexual health as "the integration of physical, affective, intellectual and social aspects of a sexual being, in such a manner that from those aspects comes the enrichment and development of human personality, communication and love".

Integration of functional myotubes with a Bio-MEMS device for non-invasive interrogation.

PubMed

Wilson, Kerry; Molnar, Peter; Hickman, James

2007-07-01

We have developed a biological micro-electromechanical system (Bio-MEMS) device consisting of surface-modified microfabricated silicon cantilevers and an AFM detection apparatus for the study of cultured myotubes. With this system we are able to selectively stimulate the myotubes as well as report on a variety of physiological properties of the myotubes in real time and in a high-throughput manner. This system will serve as the foundation for future work integrating multiple tissue types for the creation of Bio-MEMS analogues of complex tissues and biological circuits.

Analytical methods for solving boundary value heat conduction problems with heterogeneous boundary conditions on lines. I - Review

NASA Astrophysics Data System (ADS)

Kartashov, E. M.

1986-10-01

Analytical methods for solving boundary value problems for the heat conduction equation with heterogeneous boundary conditions on lines, on a plane, and in space are briefly reviewed. In particular, the method of dual integral equations and summator series is examined with reference to stationary processes. A table of principal solutions to dual integral equations and pair summator series is proposed which presents the known results in a systematic manner. Newly obtained results are presented in addition to the known ones.

A link representation for gravity amplitudes

NASA Astrophysics Data System (ADS)

He, Song

2013-10-01

We derive a link representation for all tree amplitudes in supergravity, from a recent conjecture by Cachazo and Skinner. The new formula explicitly writes amplitudes as contour integrals over constrained link variables, with an integrand naturally expressed in terms of determinants, or equivalently tree diagrams. Important symmetries of the amplitude, such as supersymmetry, parity and (partial) permutation invariance, are kept manifest in the formulation. We also comment on rewriting the formula in a GL( k)-invariant manner, which may serve as a starting point for the generalization to possible Grassmannian contour integrals.

Generic Health Management: A System Engineering Process Handbook Overview and Process

NASA Technical Reports Server (NTRS)

Wilson, Moses Lee; Spruill, Jim; Hong, Yin Paw

1995-01-01

Health Management, a System Engineering Process, is one of those processes-techniques-and-technologies used to define, design, analyze, build, verify, and operate a system from the viewpoint of preventing, or minimizing, the effects of failure or degradation. It supports all ground and flight elements during manufacturing, refurbishment, integration, and operation through combined use of hardware, software, and personnel. This document will integrate Health Management Processes (six phases) into five phases in such a manner that it is never a stand alone task/effort which separately defines independent work functions.

Tissue aging: the integration of collective and variant responses of cells to entropic forces over time.

PubMed

Todhunter, Michael E; Sayaman, Rosalyn W; Miyano, Masaru; LaBarge, Mark A

2018-06-13

Aging is driven by unavoidable entropic forces, physicochemical in nature, that damage the raw materials that constitute biological systems. Single cells experience and respond to stochastic physicochemical insults that occur either to the cells themselves or to their microenvironment, in a dynamic and reciprocal manner, leading to increased age-related cell-to-cell variation. We will discuss the biological mechanisms that integrate cell-to-cell variation across tissues resulting in stereotypical phenotypes of age. Copyright © 2018 Elsevier Ltd. All rights reserved.

49 CFR 192.937 - What is a continual process of evaluation and assessment to maintain a pipeline's integrity?

Code of Federal Regulations, 2010 CFR

2010-10-01

... Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Gas Transmission Pipeline Integrity Management § 192.937 What is a...

Analytical Approaches to Verify Food Integrity: Needs and Challenges.

PubMed

Stadler, Richard H; Tran, Lien-Anh; Cavin, Christophe; Zbinden, Pascal; Konings, Erik J M

2016-09-01

A brief overview of the main analytical approaches and practices to determine food authenticity is presented, addressing, as well, food supply chain and future requirements to more effectively mitigate food fraud. Food companies are introducing procedures and mechanisms that allow them to identify vulnerabilities in their food supply chain under the umbrella of a food fraud prevention management system. A key step and first line of defense is thorough supply chain mapping and full transparency, assessing the likelihood of fraudsters to penetrate the chain at any point. More vulnerable chains, such as those where ingredients and/or raw materials are purchased through traders or auctions, may require a higher degree of sampling, testing, and surveillance. Access to analytical tools is therefore pivotal, requiring continuous development and possibly sophistication in identifying chemical markers, data acquisition, and modeling. Significant progress in portable technologies is evident already today, for instance, as in the rapid testing now available at the agricultural level. In the near future, consumers may also have the ability to scan products in stores or at home to authenticate labels and food content. For food manufacturers, targeted analytical methods complemented by untargeted approaches are end control measures at the factory gate when the material is delivered. In essence, testing for food adulterants is an integral part of routine QC, ideally tailored to the risks in the individual markets and/or geographies or supply chains. The development of analytical methods is a first step in verifying the compliance and authenticity of food materials. A next, more challenging step is the successful establishment of global consensus reference methods as exemplified by the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals initiative, which can serve as an approach that could also be applied to methods for contaminants and adulterants in food. The food industry has taken these many challenges aboard, working closely with all stakeholders and continuously communicating on progress in a fully transparent manner.

Fluorescent nanocolloids for differential labeling of the endocytic pathway and drug delivery applications

NASA Astrophysics Data System (ADS)

Delehanty, James B.; Spillmann, Christopher M.; Naciri, Jawad; Algar, W. Russ; Ratna, Banahalli R.; Medintz, Igor L.

2013-02-01

The demonstration of fine control over nanomaterials within biological systems, particularly in live cells, is integral for the successful implementation of nanoparticles (NPs) in biomedical applications. Here, we show the ability to differentially label the endocytic pathway of mammalian cells in a spatiotemporal manner utilizing fluorescent nanocolloids (NCs) doped with a perylene-based dye. EDC-based conjugation of green- and red-emitting NCs to the iron transport protein transferrin resulted in stable bioconjugates that were efficiently endocytosed by HEK 293T/17 cells. The staggered delivery of the bioconjugates allowed for the time-resolved, differential labeling of distinct vesicular compartments along the endocytic pathway in a nontoxic manner. We further demonstrated the ability of the NCs to be impregnated with the anticancer therapeutic, doxorubicin. Delivery of the drug-doped nanoconjugates resulted in the intracellular release and nuclear accumulation of doxorubicin in a time- and dose-dependent manner. We discuss our results in the context of the utility of such materials for NP-mediated drug delivery applications.

[Health management as part of leadership in public administration].

PubMed

Matyssek, A K

2012-02-01

Leadership includes two tasks within public administration: leading employees by creating healthy working conditions and being led by others. The basis of leading others in a healthy way means dealing with oneself in a healthy manner; this includes typical healthy behavior (i.e., physical activity, improved nutrition, not smoking), which allows for recovery by a good work-life balance and a sensitive dealing with one's own limits. Given these conditions of healthy self care, managers are able to act as role models and lead their employees in a healthy manner. Leading in a healthy manner means showing appreciation, being interested in the employees ("caring"), integrating them in decision-making, allowing transparency, improving the working atmosphere, and finally reducing stress and increasing resources. The latter includes social support, which decreases the danger of employees burning out. The article presents the concept of a 2-day training that is designed for managers in order to raise their awareness for duties related to health management in public administration.

Development of a Course Sequence for an Interdisciplinary Curriculum

ERIC Educational Resources Information Center

Ali, Muhammad

2012-01-01

Interdisciplinary curriculum development is challenging in the sense that materials from more than one discipline have to be integrated in a seamless manner. A faculty member has to develop expertise in multiple disciplines in order to teach an interdisciplinary course, or the course has to be team-taught. Both approaches are difficult to…

Creating Practice Ready, Well and Professional Law Graduates

ERIC Educational Resources Information Center

Ferguson, Anneka

2015-01-01

There is a growing movement to create successful, ethical, well-rounded and practice ready legal professionals both in terms of their content knowledge and their mental well-being. As a Legal Teaching "profession" it is incumbent on us to answer this call in a responsive, creative, integrated, well researched and evaluated manner. This…

Raising Awareness about Climate Change in Pacific Communities

ERIC Educational Resources Information Center

McNamara, Karen Elizabeth

2013-01-01

Community-based climate change projects in the Pacific typically seek to raise the awareness of locals about the consequences of climate change and changing weather patterns. A key concern is that such activities might be done in an ad hoc manner, with little consideration of local relevance, audience and the integration of local experiences and…