Science.gov

Sample records for intellectual property strategy

  1. International intellectual property strategies for therapeutic antibodies

    PubMed Central

    2011-01-01

    Therapeutic antibodies need international patent protection as their markets expand to include industrialized and emerging countries. Because international intellectual property strategies are frequently complex and costly, applicants require sound information as a basis for decisions regarding the countries in which to pursue patents. While the most important factor is the size of a given market, other factors should also be considered. PMID:22123063

  2. Intellectual property protection: strategies for antibody inventions.

    PubMed

    Storz, Ulrich

    2011-01-01

    In the last decade, therapeutic antibodies have become one of the commercially most successful classes of biopharmaceutical drugs. Major drug manufacturers who have successfully managed to occupy this new market, as well as biotechnology firms, some of which have experienced a quick growth and are now on par with the former, owe part of their success to suitable intellectual property strategies. This article provides an overview of the current thinking on antibody-related patents, and discusses strategies for protecting the antibody products of the future.

  3. Intellectual Property.

    ERIC Educational Resources Information Center

    Swinson, John V.

    2000-01-01

    Intellectual property is a term that covers a number of different rights. Considers issues such as what are the basic forms of intellectual property; who owns the intellectual property created by a teacher; who owns intellectual property created by students; and use of downloaded materials from the internet. (Author/LM)

  4. Intellectual property.

    PubMed

    Brown, W M

    2000-01-01

    "Intellectual property" (IP) is a generic legal term for patents, copyrights, and trademarks, all of which provide legal rights to protect ideas, the expression of ideas, and the inventors of such ideas (1). Intellectual property has many of the characteristics of real property (houses, buildings, and so forth); intellectual property can be bought, sold, assigned, and licensed. Additionally, the owner of IP can prevent "trespass" on his property by others, though in IP this is referred to as infringement. A patent provides legal protection for a new invention, that is, an application of a new idea, discovery, or concept that is useful. Copyright provides legal protection from copying for any creative work (e.g., works of art, literature [fiction ornonfiction], music, lyrics, photographs), as well as business and scientific publications, computer software, and compilations of information. A trademark provides rights to use symbols, particular words, logos, or other markings that indicate the source of a product or service. A further method of benefitting from an invention is simply to keep it secret, rather than to disclose it; the most famous trade secret of all time is the formula for Coca-Cola, still a closely guarded secret to this day (2,3). Trade secrets have the advantage that they never expire, but special measures are required to ensure the continued secrecy, and should it be violated, there is little legal protection for the owner (2,3).

  5. Protection of Intellectual Property.

    ERIC Educational Resources Information Center

    Hoffman, Gary M.; McGrath, William T.

    1990-01-01

    The first of two articles discusses the extent to which piracy of intellectual property hurts the U.S. economy, the role of developing nations in piracy, and who benefits from the protection of intellectual property. The second explores the implications of a Supreme Court ruling on copyrighting of computer programs created by independent…

  6. The Implications of Incumbent Intellectual Property Strategies for Open Source Software Success and Commercialization

    ERIC Educational Resources Information Center

    Wen, Wen

    2012-01-01

    While open source software (OSS) emphasizes open access to the source code and avoids the use of formal appropriability mechanisms, there has been little understanding of how the existence and exercise of formal intellectual property rights (IPR) such as patents influence the direction of OSS innovation. This dissertation seeks to bridge this gap…

  7. Statement on Intellectual Property

    ERIC Educational Resources Information Center

    American Association of University Professors, 2014

    2014-01-01

    The management of university-generated intellectual property is complex and carries significant consequences for those involved in direct negotiations (faculty inventors, companies, university administrators, attorneys, and invention-management agents) as well as those who may be affected (competing companies, the public, patients, and the wider…

  8. An intellectual property primer.

    PubMed

    Penner, Mark D

    2008-06-01

    While many may think of it as an "invention" of the modern age, intellectual property ("IP") has existed since at least as early as the 17th Century with the advent of the Statute of Monopolies in the U.K. Intellectual property has evolved significantly since then into an important aspect of modern day society touching all of our lives in some form or another Canadian health care in the 21st Century is no exception. This article attempts to provide health care professionals who may not be familiar with this subject matter with a general overview of what is "intellectual property". Many readers may be aware ofintellectual property on some level but may not understand how the various types of IP function and interrelate, as well as the possible impact on the nature and scope of health care services. The purpose of this article is to attempt to provide the reader with the tools, definition and 'jargon" to understand IP so that they can appreciate the issues discussed in greater detail in the remaining papers of this special edition.

  9. [Robots and intellectual property].

    PubMed

    Larrieu, Jacques

    2013-12-01

    This topic is part of the global issue concerning the necessity to adapt intellectual property law to constant changes in technology. The relationship between robots and IP is dual. On one hand, the robots may be regarded as objects of intellectual property. A robot, like any new machine, could qualify for a protection by a patent. A copyright may protect its appearance if it is original. Its memory, like a database, could be covered by a sui generis right. On the other hand, the question of the protection of the outputs of the robot must be raised. The robots, as the physical embodiment of artificial intelligence, are becoming more and more autonomous. Robot-generated works include less and less human inputs. Are these objects created or invented by a robot copyrightable or patentable? To whom the ownership of these IP rights will be allocated? To the person who manufactured the machine ? To the user of the robot? To the robot itself? All these questions are worth discussing.

  10. Who Owns Faculty Intellectual Property?

    ERIC Educational Resources Information Center

    Distance Education Report, 2000

    2000-01-01

    Examines definitions of ownership relevant to faculty's intellectual property. Highlights exclusive rights that copyright owners hold under Section 106 of the 1976 Copyright Act. Notes university initiatives looking into the question of intellectual property. Provides examples of "significant" resources which in the case of public…

  11. Know your intellectual property rights.

    PubMed

    Khan, A

    1999-03-01

    Dismissing intellectual property rights as someone else's responsibility may not be prudent. It can jeopardize a company's future business because any new product could be unprotected, or even worse, belong to someone else. This article explains how a little strategic planning and due diligence can help prevent unnecessary legal costs. Much of a company's value can be tied up in intangible assets such as patents, trademarks and copyright, and an intellectual property audit helps assess its true worth.

  12. Legal ramifications of intellectual property

    NASA Technical Reports Server (NTRS)

    Kempf, Robert F.

    1990-01-01

    Recent government policy changes that have resulted in encouraging or requiring increased intellectual property rights of federally funded research and development activities are examined. The reasons for these changes are discussed, including considerations related to technology transfer, patent rights, copyrights, trade secrets, and computer software issues. The effect of these changes on traditional approaches to the dissemination of federally funded scientific and technical information is considered and predictions concerning future trends in intellectual property rights are given.

  13. Legal ramifications of intellectual property

    NASA Technical Reports Server (NTRS)

    Kempf, Robert F.

    1990-01-01

    Recent government policy changes that have resulted in encouraging or requiring increased intellectual property rights of Federally funded research and development activities are examined. The reasons for these changes are discussed, including considerations related to technology transfer, patent rights, copyrights, trade secrets, and computer software issues. The effect of these changes on traditional approaches to the dissemination of Federally funded scientific and technical information is considered and predictions concerning future trends in intellectual property rights are given.

  14. INTELLECTUAL PROPERTY: Industry and Agency Concerns Over Intellectual Property Rights

    DTIC Science & Technology

    2007-11-02

    march in” and grant a license to a third party to use the patent. This action may also be taken to alleviate health and safety concerns . While “march-in...General Accounting Office GAO For Release on Delivery Expected at 10:00 a.m. Friday, May 10, 2002 INTELLECTUAL PROPERTY Industry and Agency Concerns Over...Page Report Date 10MAY2002 Report Type N/A Dates Covered (from... to) - Title and Subtitle INTELLECTUAL PROPERTY: Industry and Agency Concerns Over

  15. Intellectual Property Law as an Internal Limit on Intellectual Property Rights and Autonomous Source of Liability for Intellectual Property Owners

    ERIC Educational Resources Information Center

    Judge, Elizabeth F.

    2007-01-01

    This article considers the interplay between intellectual property rights and classic property rights raised by Hoffman v. Monsanto (2005) and advances the idea that intellectual property law can serve as an autonomous source of liability for intellectual property owners. The article develops the conceptual advantages of demarcating physical and…

  16. Biotechnology as an intellectual property.

    PubMed

    Adler, R G

    1984-04-27

    Recent advances in biotechnology have created many public policy and legal issues, one of the most significant of which is the treatment of biotechnological industrial products, particularly under the patent system. Patents represent one of several types of intellectual property; their ownership confers the right to exclude others from benefitting from the tangible products of a proprietary subject matter. Intellectual property law and its protections will play a major role in the rate at which biotechnology develops in the United States. In this article biotechnological intellectual property issues are reviewed in the context of their underlying legal requirements. The implications of other factors, such as international competition, research funding, and gene ownership, are also considered.

  17. Getting smart about intellectual property

    NASA Astrophysics Data System (ADS)

    Horwitz, Bruce A.

    2010-08-01

    Intellectual Property, particularly a patent portfolio, is a critical part of many companies' assets. Yet many of these companies act dumb when it comes to Intellectual Property. Blundering forward without a plan or a manager, the company may throw money at a patent attorney pursuing a patent of little value; it may fool itself into thinking it has protection with a "provisional patent" it may fail to act in a timely fashion and lose its rights to a valuable patent. This paper highlights some of the mistakes some companies make so that you can avoid falling into the same pitfalls.

  18. Innovation in Neurosurgery: Intellectual Property Strategy and Academia/Industrial Collaboration.

    PubMed

    Murayama, Yuichi

    2016-09-15

    Neurosurgery has tremendous possibilities for development of innovative medical devices. However, most of the neurosurgical devices used in Japan are imported products. Promotion and development of domestic medical devices is highly encouraged and it is one of the pillars of Prime Minister Shinzo Abe's growth strategy of Japanese economy. Innovative "Made in Japan" medical devices can be developed by interdisciplinary collaboration between industries and academic institutions. Proper orientation of medical and engineering education, social and administrative awareness of the need of facilitating the medical devices creative process with corresponding regulatory changes, and appropriate medical and technological infrastructure establishment are needed for stimulating medical device innovation.

  19. Innovation in Neurosurgery: Intellectual Property Strategy and Academia/Industrial Collaboration

    PubMed Central

    MURAYAMA, Yuichi

    2016-01-01

    Neurosurgery has tremendous possibilities for development of innovative medical devices. However, most of the neurosurgical devices used in Japan are imported products. Promotion and development of domestic medical devices is highly encouraged and it is one of the pillars of Prime Minister Shinzo Abe’s growth strategy of Japanese economy. Innovative “Made in Japan” medical devices can be developed by interdisciplinary collaboration between industries and academic institutions. Proper orientation of medical and engineering education, social and administrative awareness of the need of facilitating the medical devices creative process with corresponding regulatory changes, and appropriate medical and technological infrastructure establishment are needed for stimulating medical device innovation. PMID:27298262

  20. Multimedia and Intellectual Property Rights.

    ERIC Educational Resources Information Center

    Dickens, Julian

    1992-01-01

    Addresses concerns that various sectors involved in the multimedia industry have concerning intellectual property rights. Issues affecting copyright owners, hardware manufacturers, and producers are discussed, including user fees, licensing agreements, quality assurances, pricing, copyright ownership, and the control of distribution and marketing.…

  1. 39 CFR 501.19 - Intellectual property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Intellectual property. 501.19 Section 501.19... POSTAGE EVIDENCING SYSTEMS § 501.19 Intellectual property. Providers submitting Postage Evidencing Systems to the Postal Service for approval are responsible for obtaining all intellectual property...

  2. 39 CFR 501.19 - Intellectual property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Intellectual property. 501.19 Section 501.19... POSTAGE EVIDENCING SYSTEMS § 501.19 Intellectual property. Providers submitting Postage Evidencing Systems to the Postal Service for approval are responsible for obtaining all intellectual property...

  3. Intellectual property and information controversy(I)

    NASA Astrophysics Data System (ADS)

    Aoyama, Hirokazu

    This paper deals with intellectual property as the results of various intellectual activities such as R & D, and intellectual proprietary rights which protect it. New technology, designs, literary works, computer programs, semiconductor chips, new plant breeding, brands, trading secrets, CI and others, and legislations which protect them are described. Then, the background of the fact that intellectual proprietary rights are emphasized as analyzed. The author points out items as follows; movement toward much larger size of R & D, generation of the areas to be newly protected, trend in enforcement of intellectual property protection, commercialization of intellectual property, trend in software evolution, movement in technological protectionism, and the present status on each item.

  4. Intellectual Property and Copyright Issues in Online Learning Environments.

    ERIC Educational Resources Information Center

    Szanto, Edit

    2001-01-01

    Provides an overview of intellectual property and copyright issues as they relate to online learning environments. Includes a historical perspective; laws and regulations; liability; Web-related issues; higher education; distance learning; compliance strategies; and policy recommendations. (Author/LRW)

  5. 32 CFR 37.1310 - Intellectual property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Intellectual property. 37.1310 Section 37.1310... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1310 Intellectual property. Inventions, data, works of authorship, and other intangible products of intellectual effort...

  6. 32 CFR 37.1310 - Intellectual property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1310 Intellectual property. Inventions, data, works of authorship, and other intangible products of intellectual effort...

  7. Intellectual property and information controversy (II)

    NASA Astrophysics Data System (ADS)

    Aoyama, Hirokazu

    As advanced information has been proceeded rapidly, intellectual property has become more important than ever as business resources of enterprises. Based on the former report by the author "present status of and trend in intellectual property" this paper describes "information" related intellectual property controversy which have been occurred, that is, 1) affairs related to computer hardwares and softwares (the case of compatible machines and OS, the case of application softwares, computer crimes) and 2) affairs on trade secret (the case of revealing enterprises'secret, the case of industrial espionage). It also discusses how intellectual property should be protected and utilized from now on.

  8. 10 CFR 603.1285 - Intellectual property.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Intellectual property. 603.1285 Section 603.1285 Energy... Used in this Part § 603.1285 Intellectual property. Patents, trademarks, copyrights, mask works, protected data, and other forms of comparable property protected by Federal law and foreign counterparts....

  9. 10 CFR 603.1285 - Intellectual property.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Intellectual property. 603.1285 Section 603.1285 Energy... Used in this Part § 603.1285 Intellectual property. Patents, trademarks, copyrights, mask works, protected data, and other forms of comparable property protected by Federal law and foreign counterparts....

  10. [Intellectual property in natural sciences].

    PubMed

    Twardowski, Tomasz

    2008-01-01

    The way from scientific finding through invention to production line and finally to the consument is long and expensive and patent should be taken into account. This is evident because the investment connected with the new application needs clear definition of intellectual property rights. Independently what we personally think about patenting in nature sciences--this is a common practice around the world. The positive and negative parameters of patenting are focus on biotechnology. The development of biotechnology is a cumulative effect of co-operation of several disciplines: biology, biochemistry, chemistry, engineering, genetics, medicines and pharmacy and many more. Between not cited here is law and consequently the needs of cooperation between researchers and lawyers. There are several barriers in this co-operation, for example: nomenclature as well as the way of thinking. These borders could be pass only with intercommunication and cross-understanding. The dialog and transfer of knowledge is a must for understanding the nomenclature, terminology of nature by lawyers and by researchers in case of law. Polish legislation concerning intellectually rights is regulated by the law "Prawo własności przemysłowej" (30 June, 2000; Dz. U. 2003, Nr 119, pos. 1117, with later amendments). This legislation is related to European Union directives and Munich Convention. Accordingly patenting of product and process is possible in Poland. However, the procedure is time and money consuming, particularly in the case of patent submission in several countries. Amendment of the Polish law to biotechnology made possible patenting of living organism and their parts. It is worth to stress that patented inventions can be used free of charge for research and teaching.

  11. Ethnobotany and intellectual property rights.

    PubMed

    Barton, J H

    1994-01-01

    Contemporary intellectual property law permits only the patenting of an identified active principle from a plant, not the plant or folk information relating to medicinal properties of a plant. The most significant rights of indigenous peoples are those deriving from physical control of the plants and the knowledge pertaining to their use. This control can provide the basis for trade secret protection. Such agreements are enforceable in developed nations and should become so in developing nations. There have been recent efforts to strengthen indigenous peoples' rights over genetic resources and relevant folk knowledge but the most far-reaching of these are not yet a part of international law. Pharmaceutical patents combined with trade secrecy can allow firms to develop and market products and ensure that the nation and/or people from which the material or information was derived are properly rewarded. This does not provide protection from competition or with respect to derived knowledge nor does it act retrospectively. At present, rights under the United Nations Convention on Biodiversity are prospective only. These rights belong to the nation and there is little legal pressure for recompense to be shared with indigenous peoples. A uniform agreement that deals in a balanced way with the relative rights of indigenous peoples and of their governments should be developed by non-governmental organizations.

  12. Management of intellectual property rights in India: An updated review

    PubMed Central

    Tiwari, R.; Tiwari, G.; Rai, A. K.; Srivastawa, Birendra

    2011-01-01

    The World Trade Organization's agreement on Trade-Related Aspects of Intellectual Property Rights set global minimum standards for the protection of intellectual property, substantially increasing and expanding intellectual property rights, and generated clear gains for the pharmaceutical industry and the developed world. The present review elaborates all aspects of Intellectual Property Rights in detail, along with their protection criteria. PMID:22470229

  13. Management of intellectual property rights in India: An updated review.

    PubMed

    Tiwari, R; Tiwari, G; Rai, A K; Srivastawa, Birendra

    2011-01-01

    The World Trade Organization's agreement on Trade-Related Aspects of Intellectual Property Rights set global minimum standards for the protection of intellectual property, substantially increasing and expanding intellectual property rights, and generated clear gains for the pharmaceutical industry and the developed world. The present review elaborates all aspects of Intellectual Property Rights in detail, along with their protection criteria.

  14. Promoting justice in stem cell intellectual property.

    PubMed

    Regenberg, Alan; Mathews, Debra J H

    2011-11-01

    According to the World Trade Organization, intellectual property rights are "rights given to persons over the creations of their minds. They usually give the creator an exclusive right over the use of his/her creation for a certain period of time." The rationale behind intellectual property rights is to offer a quid pro quo, between creators and the public, intended to spur innovation. Inventors gain exclusivity (and an opportunity for profits) in exchange for publicly disclosing details about their creations. The public gains free access to information - information that can then be used to support further innovation. Innovation is seen as an inherent good in this context, as it can lead to the development of things people need (e.g., treatments for disease, green energy technologies or a better mousetrap). Exclusive rights to intellectual property are managed via patents and licenses, with patenting being primarily regulated at the national level. Intellectual property rights are the dominant mechanism used in innovation policy, particularly in science. However, myriad modifications and alternatives to intellectual property rights have been proposed and utilized, including patent pooling, intellectual property exchanges and clearing houses, innovation prizes and open-source licenses. The challenges related to competing models of innovation policy present in a fairly consistent manner across most fields of science. However, this paper will focus exclusively on intellectual property rights and models of innovation policy in the context of stem cell science. It is not that the issues themselves are unique in this context, but rather that there are a series of factors that make a discussion of intellectual property rights and models of innovation policy particularly important in the context of stem cell science.

  15. Analysis of Intellectual Property Protection Issues in Offshore Outsourcing

    ERIC Educational Resources Information Center

    Singh, Satinder Pal

    2013-01-01

    Offshore outsourcing is a business strategy that involves contracting with a partner who can take over certain aspects of a company's business, such as information technology (IT) functions, in the interests of efficiency and cost savings. The purpose of this study was to analyze the intellectual property protection issues to achieve a better…

  16. Pluralism and Context: Intellectual Property and the Social Understandings of Intellectual Goods

    ERIC Educational Resources Information Center

    Lenhart, Laura

    2014-01-01

    Intellectual property affects an increasingly large range of social life. Despite the breadth of goods and activities affected by intellectual property schemas, policy-makers, legislators, jurists and even many social theorists have a narrow understanding of the basis for instituting intellectual property rights and understanding their limits:…

  17. 10 CFR 603.1285 - Intellectual property.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Intellectual property. 603.1285 Section 603.1285 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms..., protected data, and other forms of comparable property protected by Federal law and foreign counterparts....

  18. Intellectual property rights: An overview and implications in pharmaceutical industry

    PubMed Central

    Saha, Chandra Nath; Bhattacharya, Sanjib

    2011-01-01

    Intellectual property rights (IPR) have been defined as ideas, inventions, and creative expressions based on which there is a public willingness to bestow the status of property. IPR provide certain exclusive rights to the inventors or creators of that property, in order to enable them to reap commercial benefits from their creative efforts or reputation. There are several types of intellectual property protection like patent, copyright, trademark, etc. Patent is a recognition for an invention, which satisfies the criteria of global novelty, non-obviousness, and industrial application. IPR is prerequisite for better identification, planning, commercialization, rendering, and thereby protection of invention or creativity. Each industry should evolve its own IPR policies, management style, strategies, and so on depending on its area of specialty. Pharmaceutical industry currently has an evolving IPR strategy requiring a better focus and approach in the coming era. PMID:22171299

  19. Intellectual property rights: An overview and implications in pharmaceutical industry.

    PubMed

    Saha, Chandra Nath; Bhattacharya, Sanjib

    2011-04-01

    Intellectual property rights (IPR) have been defined as ideas, inventions, and creative expressions based on which there is a public willingness to bestow the status of property. IPR provide certain exclusive rights to the inventors or creators of that property, in order to enable them to reap commercial benefits from their creative efforts or reputation. There are several types of intellectual property protection like patent, copyright, trademark, etc. Patent is a recognition for an invention, which satisfies the criteria of global novelty, non-obviousness, and industrial application. IPR is prerequisite for better identification, planning, commercialization, rendering, and thereby protection of invention or creativity. Each industry should evolve its own IPR policies, management style, strategies, and so on depending on its area of specialty. Pharmaceutical industry currently has an evolving IPR strategy requiring a better focus and approach in the coming era.

  20. 2 CFR 200.448 - Intellectual property.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Intellectual property. (a) Patent costs. (1) The following costs related to securing patents and copyrights are..., and of searching the art to the extent necessary to make such disclosures; (ii) Costs of preparing... Federal government; and (iii) General counseling services relating to patent and copyright matters,...

  1. Computer Software & Intellectual Property. Background Paper.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Office of Technology Assessment.

    This background paper reviews copyright, patent, and trade secret protections as these issues are related to computer software. Topics discussed include current issues regarding legal protection for computer software including the necessity for defining intellectual property, determining what should or should not be protected, commerical piracy,…

  2. Intellectual Property in the Connected Age.

    PubMed

    Skiba, Diane J

    2015-07-01

    Concerns about intellectual property for nursing are becoming increasingly acute as information becomes highly accessible in the digital age. Nurse faculty members need to check policies of the agencies that they work for to evaluate explicit written policies for their protection and full understanding of the agency's rights.

  3. Who Owns Online Course Intellectual Property?

    ERIC Educational Resources Information Center

    Kranch, Douglas A.

    2008-01-01

    Faculty develop intellectual property needed for online courses while employed by an academic institution. That institution has a claim on the copyright because the instructional materials developed by the faculty members could be seen as "works for hire." On the other hand, both tradition and case law have seen faculty as the copyright…

  4. "Intellectual Property" and Knowledge Creation in Disorganisations

    ERIC Educational Resources Information Center

    Vaden, Tere

    2006-01-01

    Given the current forms of economic production and corporate markets, the liberating and democratic potential of digital information is counteracted by the concentration of media ownership, as well as by policy, legislation, and the development of proprietary forms of technology. The notion of "intellectual property" produces artificial scarcity…

  5. Indigenous Research, Publishing, and Intellectual Property

    ERIC Educational Resources Information Center

    Madsen, Kenneth D.

    2008-01-01

    In this article, the author makes a case for a greater understanding of Native research and how the academy can learn from it to become more sensitive to the concerns of the research constituencies. How academics handle the intellectual property that results from their research is also critical. What they make public and what they decide is better…

  6. Intellectual Property: Policies and Policy Makers.

    ERIC Educational Resources Information Center

    Sanders, Diana W.

    2001-01-01

    Used modified version of 1978 National Association of College and University Business Officers survey instrument to investigate intellectual-property policies at 38 (of 210) 4-year institutions of higher education in the 15 Southern Regional Education Board states. Finds, for example, that in the majority of institutions, top administrators are…

  7. The Mystery of Intellectual Property Revealed.

    ERIC Educational Resources Information Center

    Crawford, Julia

    1999-01-01

    Presents examples that librarians can use with any age group to explain the differences between patents, trademarks, and copyrights. Defines three basic types of intellectual property--patent, trademark, and copyright, followed by three sample dialogues to explain all three. Highlights further activities and practical applications. (AEF)

  8. Distance Education and Digital Intellectual Property Issues

    ERIC Educational Resources Information Center

    DiRamio, David C.; Kops, Gerald C.

    2004-01-01

    While many colleges and universities enthusiastically push forward to create new online courses, important campus policies regarding copyright and academic intellectual property in the digital age lag behind. Policy questions regarding ownership and control of online courses and how the new TEACH Act affects the concept of fair use of…

  9. Managing Intellectual Property for Distance Learning

    ERIC Educational Resources Information Center

    Johnson, Liz

    2006-01-01

    Managing permissions for hundreds of pieces of intellectual property (IP) can be a daunting task for any course, but it is vital in distance learning courses because of legal implications specific to the online environment. In 1998, the Digital Millennium Copyright Act (DMCA)severely limited the use of copyrighted materials in distance learning.…

  10. Drug patents and intellectual property rights.

    PubMed

    Raj, Gerard Marshall; Priyadarshini, Rekha; Mathaiyan, Jayanthi

    2015-04-01

    Inquisitive scientists are untiring and relentless in the hard work they perform day in and day out. In this pursuit, a researcher has to exercise their intellectual expertise in its entirety. Eventually, all credit of the invention is vested with the inventor who has the right of control over their intellectual creation. Likewise, pharmaceutical companies spend extravagantly in successfully introducing a novel drug from hundreds and thousands of lead compounds. Hence, it is a prerogative for every company to protect its innovative products from unauthorized duplication. Certainly, "patents" are the sole custodians of these products of medical intelligence - the drugs! This review focuses on the various intricacies of the drug patent system all over the world with special emphasis on India, Europe, and the United States. A note on other intellectual properties such as copyrights, trademarks, and designs is also added.

  11. Data management in academic settings: an intellectual property perspective.

    PubMed

    Geller, Lisa

    2010-12-01

    Intellectual property can be an important asset for academic institutions. Good data management practices are important for capture, development and protection of intellectual property assets. Selected issues focused on the relationship between data management and intellectual property are reviewed and a thesis that academic institutions and scientists should honor their obligations to responsibly manage data.

  12. 10 CFR 603.550 - Acceptability of intellectual property.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... costs associated with intellectual property if the costs are based on sound estimates of market value of... 10 Energy 4 2012-01-01 2012-01-01 false Acceptability of intellectual property. 603.550 Section... AGREEMENTS Pre-Award Business Evaluation Cost Sharing § 603.550 Acceptability of intellectual property....

  13. 10 CFR 603.550 - Acceptability of intellectual property.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... costs associated with intellectual property if the costs are based on sound estimates of market value of... 10 Energy 4 2014-01-01 2014-01-01 false Acceptability of intellectual property. 603.550 Section... AGREEMENTS Pre-Award Business Evaluation Cost Sharing § 603.550 Acceptability of intellectual property....

  14. 10 CFR 603.550 - Acceptability of intellectual property.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... costs associated with intellectual property if the costs are based on sound estimates of market value of... 10 Energy 4 2013-01-01 2013-01-01 false Acceptability of intellectual property. 603.550 Section... AGREEMENTS Pre-Award Business Evaluation Cost Sharing § 603.550 Acceptability of intellectual property....

  15. What Every School Should Know about Intellectual Property

    ERIC Educational Resources Information Center

    Stroder, Rebecca S.

    2006-01-01

    Most institutions aren't aware of their valuable intellectual property, and some believe they have intellectual property when they don't, which can lead to expensive lawsuits or licensing fees. "Intellectual property" generally consists of copyrights, trademarks, and patents. Most familiar is copyright, the statutory protection mechanism for…

  16. Towards Hybrid Therapeutic Strategies in Intellectual Disabilities

    ERIC Educational Resources Information Center

    Rondal, Jean-A.; Lang, Sc.

    2009-01-01

    I present and discuss what I see as a decisive convergence between future (no longer science fiction) genetic therapies in human beings with intellectual disabilities and standard (so to speak) neurobehavioral interventions. This crossing will lead to a radical modification in the life prospect of people with intellectual disability from genetic…

  17. Introduction to intellectual property rights for investigators in health research and institutional intellectual property policy.

    PubMed

    Shemdoe, Georges S

    2009-11-01

    The concept of Intellectual Property (IP) in the domain of technology has assumed enhanced importance and the subject matter has attracted more interest with time. As the world moves towards a knowledge-based economy, where wealth creation is no longer based on the capital investment per se, but rather more and more on the brainpower and ability to create, Intellectual Property has become an integral part of world business and a major source for wealth creation and economic growth (ARIPO, 2002). In recognizing the importance of IPR, African Malaria Network Trust (AMANET) has decided to include a module of intellectual property rights in its Health Research Ethics Training Courses for Investigators. This paper is introducing the subject of IP to investigators in health research so that they are able to recognize its importance as IP creators and utilizers of the IP system.

  18. Intellectual Property Rights and The Classroom: What Teachers Can Do

    ERIC Educational Resources Information Center

    Falcon, Raymond

    2010-01-01

    Intellectual property rights restrict teachers' and students' ability to freely explore the intellectual realms of the classroom. Copyright laws protect the author and their work but disable other intellectuals from investigating probable learning environments. This paper will look at key issues where educational institutions are conflicting with…

  19. Is the Non-rivalrousness of Intellectual Objects a Problem for the Moral Justification of Economic Rights to Intellectual Property?

    PubMed

    Varelius, Jukka

    2015-08-01

    It is often argued that the fact that intellectual objects-objects like ideas, inventions, concepts, and melodies-can be used by several people simultaneously makes intellectual property rights impossible or particularly difficult to morally justify. In this article, I assess the line of criticism of intellectual ownership in connection with a central category of intellectual property rights, economic rights to intellectual property. I maintain that it is unconvincing.

  20. Intellectual Property: What Do Teachers and Students Know?

    ERIC Educational Resources Information Center

    Starkey, Louise; Corbett, Susan; Bondy, Ann; Davidson, Susan

    2010-01-01

    As society changes from an industrial to a knowledge era increasing importance and value is being placed on intellectual property rights. Technology teachers need to have pedagogical content knowledge of intellectual property if they are to incorporate it into their learning programmes to enable students to consider how to respect others'…

  1. Essjay's "Ethos": Rethinking Textual Origins and Intellectual Property

    ERIC Educational Resources Information Center

    Brown, James J., Jr.

    2009-01-01

    Discussions of intellectual property are often the focus of rhetoric and composition research, and the question of textual origins grounds these discussions. Through an examination of Wikipedia, the online encyclopedia anyone can edit, this essay addresses disciplinary concerns about textual origins and intellectual property through a discussion…

  2. 'Food for Engineers': Intellectual Property Education for Innovators

    ERIC Educational Resources Information Center

    Soetendorp, Ruth

    2004-01-01

    Intellectual property competence can assist individuals and organizations to capitalize on opportunities presented by accelerating developments in the knowledge economy. Engineers translate ideas into concrete solutions, which are frequently useful and commercially valuable, if the intrinsic intellectual property has been identified and protected.…

  3. Introduction: Intellectual Property on Campus: Computers, Copyright, and Cyperspace.

    ERIC Educational Resources Information Center

    Olivas, Michael A.

    2000-01-01

    After highlighting the importance of intellectual property in higher education, provides a brief overview of the issue's articles presented as papers at a December 1999 research conference co-sponsored by the University of Houston Law Center's Institute for Higher Education Law and Governance and Institute for Intellectual Property and Information…

  4. Intellectual Property and Higher Education: Challenges and Conflicts

    ERIC Educational Resources Information Center

    Van Dusen, Virgil

    2013-01-01

    Intellectual property has become a highly coveted asset that can potentially reap a financial windfall for the owner who exploits its utility. Higher education has focused on the discovery of new knowledge, which can translate into intellectual property, but legislation, higher education policy, and/or contractual engagement may dictate ownership…

  5. Intellectual Property in "College English"--and English Studies

    ERIC Educational Resources Information Center

    DeVoss, Danielle Nicole

    2013-01-01

    In this review, I look back to the first issue of College English, and then across the years to trace the ways in which "Intellectual Property" (and this distinction from intellectual property is important) has been addressed by authors in the pages of the journal. I distinguish two periods of time marked by different approaches to IP issues, and…

  6. Intellectual Property in Higher Education: A Legal Compendium. Second Edition.

    ERIC Educational Resources Information Center

    Byman, Abigail, Ed.; Geller, Randolph, Ed.

    This compendium focuses on intellectual property law, which includes copyrights, patents, and trademarks as well as applications of intellectual property in distance learning software, the Internet, and research data. It includes formal journal articles, policies, and outlines from the National Association of College and University Attorneys. Ten…

  7. 76 FR 60114 - Section 306 Monitoring of Paraguay: Memorandum of Understanding on Intellectual Property Rights...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... successfully entered into a Memorandum of Understanding on Intellectual Property Rights. USTR subsequently... enforcement of intellectual property rights. Dates: Submissions from the general public and foreign... ``Paraguay Memorandum of Understanding on Intellectual Property Rights'' in the ``Type comment'' field...

  8. Intellectual property law: a primer for scientists.

    PubMed

    Brown, William M

    2003-03-01

    Intellectual property (IP) is a generic legal term for patents, copyrights, and trademarks, which provide legal rights to protect ideas, the expression of ideas, and the inventors and creators of such ideas. A patent provides legal protection for a new invention, an application of a new idea, discovery, or concept that is useful. Copyright provides legal protection from copying for any creative work, as well as business and scientific publications, computer software, and compilations of information. A trademark provides rights to use symbols, particular words, logos, or other markings that indicate the source of a product or service. A further method of benefiting from an invention is simply to keep it secret, rather than to disclose it a trade secret. IP impinges on almost everything scientists do. As scientists are paid to come up with ideas and aspire to patent and/or publish their work, the protection of ideas and of written works especially should be of interest and concern to all.

  9. Language revitalization in Native North America--issues of intellectual property rights and intellectual sovereignty.

    PubMed

    Tatsch, Sheri

    2004-01-01

    Language revitalization, oral tradition and epistemology are expressions of Native peoples intellectual sovereignty, and thus the foundation for indigenous intellectual property rights. As the people of California move towards language and cultural revitalization the question arises: What constitutes or constructs the definitions of intellectual property and how can appropriation of indigenous knowledge be protected? Looking at the issues faced by the California's indigenous populace and by implication, other indigenous peoples in the United States, this essay examines how protection may be afforded under the United Nations definition of 'heritage'. Given that the holding safe of a 'culture' or 'heritage' is inclusive of language, and thus has been determined to be a human right.

  10. Impact of Intellectual Property Laws on Part-Time Faculty. The Effective Voice for You.

    ERIC Educational Resources Information Center

    Duby, James R., Jr.

    This guide explains some of the intellectual property rights of part-time college faculty members and the circumstances under which faculty can defend intellectual property rights. The term "intellectual property" refers to proprietary information, materials, or products, the owner of which may possess intellectual property rights under trademark,…

  11. Intellectual property rights and technological innovation in agriculture

    SciTech Connect

    Horbulyk, T.M.

    1993-05-01

    This paper addresses the potential role and importance of an appropriate system of intellectual property rights in sustaining innovation and technological change in agriculture, a sector where the research and development process is typically cumulative in nature. The design and use of intellectual property rights as an economic incentive is illustrated by reference to Canada`s new system of Plant Breeder`s Rights, and by reference to recent economic research analyzing alternative designs for such a system. 21 refs., 1 fig.

  12. Research on Intellectual Property Conflicts Identification in Knowledge Transferring among EC Enterprises

    NASA Astrophysics Data System (ADS)

    Su, Shibin

    As the lacks of existing research about intellectual property conflicts management of EC enterprise, the paper analysis the intellectual property conflicts in knowledge transferring among EC enterprises by intellectual property types, then, the paper makes research on intellectual property conflicts identification in knowledge transferring among EC enterprises, and gives relative assumption, meanwhile, the paper makes quantities identification of intellectual property conflicts in knowledge transferring among EC enterprises by evidential theory, finally, the paper gives the further research orientations.

  13. The intellectual property management for data sharing in a German liver cancer research network.

    PubMed

    He, Shan; Ganzinger, Matthias; Knaup, Petra

    2012-01-01

    Sharing data in biomedical research networks has great potential benefits including efficient use of resources, avoiding duplicate experiments and promoting collaboration. However, concerns from data producers about difficulties of getting proper acknowledgement for their contributions are becoming obstacles for efficient and network wide data sharing in reality. Effective and convenient ways of intellectual property management and acknowledging contributions to the data producers are required. This paper analyzed the system requirements for intellectual property management in a German liver cancer research network and proposed solutions for facilitating acknowledgement of data contributors using informatics tools instead of pure policy level strategies.

  14. [Coping strategies adopted by parents of children with intellectual disabilities].

    PubMed

    Santos, Manoel Antonio Dos; Pereira-Martins, Maria Laura de Paula Lopes

    2016-10-01

    The tasks of caregiving for children with disabilities involve contextual life stressors. The study aimed to investigate the coping strategies used by parents of children with intellectual disabilities (ID). The search included articles published between 2001 and 2015 on the PubMed, LILACS and PsycINFO databases, using the following key words: intellectual disability, coping, parents, caregivers, family. Thirteen articles were selected, the majority of which adopt a cross-sectional, comparative and quantitative approach. Results indicated that caring for a person with ID is stressful for the family. Parental stress generates changes in the family dynamic and coping strategies are used to facilitate the interaction of the caregiver with the person with ID. Seeking social support in family and professional services, the union of spouses, and search for information, among others, are the main strategies used. Social support was strongly associated with strengthening of the family unit. In contrast, wishful thinking, self-blame, distancing and social isolation were negatively associated with family unity. It is necessary to sensitize health professionals and educators to embrace the theme in public policies and preventive, diagnostic and therapeutic strategies.

  15. "The Fruits of Intellectual Labor": International Student Views of Intellectual Property

    ERIC Educational Resources Information Center

    Datig, Ilka; Russell, Beth

    2015-01-01

    In this paper, we report on the results of a study conducted at New York University Abu Dhabi in the fall of 2013. Our goal in the study was to gain a global college student perspective on issues related to intellectual property, including copyright and plagiarism. We found that, contrary to popular opinion, most of our students have a solid…

  16. Education of Intellectual Properties for the Training of Creative Engineers

    NASA Astrophysics Data System (ADS)

    Ito, Yoshifumi; Kajiwara, Katuhiko; Oodan, Kyouji

    Kurume National College of Technology has obtained results concerning intellectual property education combined with inventive education. In the education program, students learn about industrial property and practical expertise such as searching the open patents, making up patent-maps, and making patent application papers to the Patent Office under the guidance of a teacher, a patent adviser and attorney. As a result, some of the creative students have already applied for patents. In the future, we are going to prepare a managing system for the intellectual property at our college for the intensification of cooperative application with the local company.

  17. Did You Say "Intellectual Property"? It's a Seductive Mirage

    ERIC Educational Resources Information Center

    Stallman, Richard M.

    2006-01-01

    The term "intellectual property" tends to warp thinking wherever it is used. It carries a bias in favor of dealing with a variety of issues as kinds of "property"; even worse, applying the term to various disparate issues focuses attention erroneously on the little that they have in common. The term should never be used, and we should not let…

  18. 75 FR 54086 - Global Intellectual Property Academy Program Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Property Academy Program Survey ACTION: Proposed collection; comment request. SUMMARY: The United States... . Include ``0651- 00xx Global Intellectual Property Academy Program Survey comment'' in the subject line of... . SUPPLEMENTARY INFORMATION I. Abstract The U.S. Patent and Trademark Office plans to survey participants of...

  19. Intellectual Property Rights and International Trade

    DTIC Science & Technology

    2008-10-20

    Estimate Methodology, p. v . 33 PhRMA, “Special 301 Submissions for 2008.” and many other developed countries, with relatively strong regulatory systems...U.S. Trade Issues, by Wayne M. Morrison. 35 Liza Porteus Viana , “Industry Losing Faith in WIPO: Debates US WTO Cases Against China,” Intellectual...Factsheet, “Anti-Counterfeiting Trade Agreement,” August 4, 2008. 89 Liza Porteus Viana , “USTR Plans Another Year of Elevating IP Protection With

  20. Synthetic biology and intellectual property rights: six recommendations.

    PubMed

    Minssen, Timo; Rutz, Berthold; van Zimmeren, Esther

    2015-02-01

    On 26th November 2013, the Danish Agency for Science, Technology and Innovation organized an expert meeting on "Synthetic Biology & Intellectual Property Rights" in Copenhagen sponsored by the European Research Area Network in Synthetic Biology (ERASynBio). The meeting brought together ten experts from different countries with a variety of professional backgrounds to discuss emerging challenges and opportunities at the interface of synthetic biology and intellectual property rights. The aim of this article is to provide a summary of the major issues and recommendations discussed during the meeting.

  1. 76 FR 7681 - Establishment of the Intellectual Property Enforcement Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... established an interagency Senior Intellectual Property Enforcement Advisory Committee (Senior Advisory... interagency Intellectual Property Enforcement Advisory Committee (Enforcement Advisory Committee), which shall... to enhance cooperation among Federal, State, and local authorities responsible for...

  2. Copyright in Cyberspace: Intellectual Property and Electronic Media and Networks.

    ERIC Educational Resources Information Center

    Wright, A. J.

    The increasing presence of electronic materials, databases, and networks in society's institutions raises a number of new questions related to copyrighted and intellectual property in cyberspace environments (e.g., How will the fair use provision of U.S. copyright law and practice be extended to electronic situations?). Such questions have…

  3. Managing intellectual property to develop medicines for the world's poorest.

    PubMed

    Fonteilles-Drabek, Sylvie; Reddy, David; Wells, Timothy N C

    2017-02-24

    It has been argued that patents impede the development and access of medicines for tropical diseases such as malaria. However, we believe that intellectual property can be a key tool to enable timely progression of drug development projects involving multiple partners and to ensure equitable access to successful products.

  4. 15 CFR 290.9 - Intellectual property rights.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.9 Intellectual property rights. (a) Awards under the... for registration as a published work in the U.S. Copyright Office. For data other than...

  5. Intellectual Property and Online Courses: Policies at Major Research Universities

    ERIC Educational Resources Information Center

    Loggie, Kathryn Ann; Barron, Ann E.; Gulitz, Elizabeth; Hohlfeld, Tina N.; Kromrey, Jeffrey D.; Sweeney, Phyllis

    2007-01-01

    This study describes an investigation of the intellectual property policies of a stratified random sample of public and private Carnegie Doctoral Research-Extensive Universities. University policies were examined to determine whether or not they included provisions for distance education materials or courseware, what provisions were made for…

  6. Intellectual property issues in holography and high tech

    NASA Astrophysics Data System (ADS)

    Reingand, Nadya

    2004-06-01

    The author with technical education background (Ph.D. in holography) shares her 3+ years of experience working on intellectual property (IP) issues that includes patents, trademarks, and copyrights. A special attention is paid to the patent issues: the application procedure, the patent requirements, the databases for prior art search, how to make the cost efficient filing.

  7. Tort Liability That May Attach to Intellectual Property Licensing.

    ERIC Educational Resources Information Center

    Norris, William R.

    1979-01-01

    Examined are elements that complicate the relationship between tort law and intellectual property licensing (patents): governmental regulation of products, legal standards, the evolution of tort doctrine, international law and practice, trademark, technology and patent licensing. Available from P.O. Box 2600, Arlington, VA 22202. (MSE)

  8. Integrating Intellectual Property Concepts into MIS Education: An Empirical Assessment

    ERIC Educational Resources Information Center

    Mykytyn, Peter P., Jr.; Mykytyn, Kathleen; Harrison, David A.

    2005-01-01

    The evolving legal environment surrounding intellectual property (IP) and its impact on information systems, especially involving electronic commerce, and the type of education and training provided by management information systems (MIS) faculty to MIS students is a relationship that has not been investigated. Although organizations are…

  9. Developments in Intellectual Property and Traditional Knowledge Protection

    ERIC Educational Resources Information Center

    Anderson, Jane

    2009-01-01

    In order to protect indigenous/traditional knowledge, intellectual property law must be leveraged in a way that is responsive to the dynamic inter-relationships between law, society and culture. Over the last decade, increased attention to Indigenous concerns has produced a wealth of literature and prompted recognition of the diverse needs of…

  10. Innovation and Intellectual Property: The Case of Genomic Patenting

    ERIC Educational Resources Information Center

    Jackson, Brian A.

    2003-01-01

    In an effort to balance static and dynamic efficiency in the production and use of knowledge, societies institute intellectual property policies. In the United States, the patent system is a well-established mechanism to provide inventors with time-limited protection of new technologies in exchange for disclosure of information about their…

  11. Intellectual Property Rights: Governing Cultural and Educational Futures

    ERIC Educational Resources Information Center

    Kapitzke, Cushla

    2006-01-01

    This article uses Nikolas Rose's theory of governmentality to examine ways in which intellectual property is imbricated in a broad spectrum of globalised and globalising discourses. Using the 2004 Australia-United States Free Trade Agreement as a case in point, it shows how discourses of culture, trade, foreign policy, and security intersect and…

  12. Protecting Student Intellectual Property in the Entrepreneurial Classroom

    ERIC Educational Resources Information Center

    Wright, Sarah L.; Katz, Jerome A.

    2016-01-01

    While universities are intensely protective of revenue streams related to intellectual property interests for the institution and professors, the financial and legal interests of students in the entrepreneurial process have largely been overlooked. This lack of attention, both in universities and in the literature, is intriguing given the…

  13. An Overview of Intellectual Property and Intangible Asset Valuation Models

    ERIC Educational Resources Information Center

    Matsuura, Jeffrey H.

    2004-01-01

    This paper reviews the economic models most commonly applied to estimate the value of intellectual property and other forms of intangible assets. It highlights the key strengths and weaknesses of these models. One of the apparent weaknesses of the most commonly used valuation models is the failure to incorporate legal rights into their…

  14. 15 CFR 290.9 - Intellectual property rights.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Intellectual property rights. 290.9 Section 290.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS...

  15. 15 CFR 290.9 - Intellectual property rights.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Intellectual property rights. 290.9 Section 290.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS...

  16. 15 CFR 290.9 - Intellectual property rights.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Intellectual property rights. 290.9 Section 290.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS...

  17. 15 CFR 290.9 - Intellectual property rights.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Intellectual property rights. 290.9 Section 290.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS...

  18. 15 CFR 296.11 - Intellectual property rights and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS TECHNOLOGY INNOVATION PROGRAM General § 296.11 Intellectual property rights and procedures. (a) Rights in... commercialize the technology in a timely fashion. (c) Patent procedures. Each award by the Program will...

  19. Valuing Local Knowledge: Indigenous People and Intellectual Property Rights.

    ERIC Educational Resources Information Center

    Brush, Stephen B., Ed.; Stabinsky, Doreen, Ed.

    Intellectual property enables individuals to gain financially from sharing unique and useful knowledge. Compensating indigenous people for sharing their knowledge and resources might both validate and be an equitable reward for indigenous knowledge of biological resources, and might promote the conservation of those resources. This book contains…

  20. Intellectual Property Rights for Indigenous Peoples: A Sourcebook.

    ERIC Educational Resources Information Center

    Greaves, Tom, Ed.

    This sourcebook presents a collection of papers focusing on the intellectual property rights (IPR) of indigenous peoples--their rights to protect and control their cultural knowledge. Subsidiary IPR goals are to manage the degree and process by which cultural knowledge is shared with outsiders and, in some instances, to be justly compensated for…

  1. 32 CFR 37.550 - May I accept intellectual property as cost sharing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false May I accept intellectual property as cost... Cost Sharing § 37.550 May I accept intellectual property as cost sharing? (a) In most instances, you should not count costs of patents and other intellectual property (e.g., copyrighted material,...

  2. 75 FR 60408 - Government Programs To Assist Businesses Protect Their Intellectual Property Rights (IPR) in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... programs for protecting the intellectual property rights of U.S. businesses, including Small- and Medium.... businesses that are: 1. Acquiring intellectual property rights in foreign markets; 2. Contemplating exporting.... businesses facing barriers related to intellectual property rights protection and enforcement in...

  3. Intellectual Property Rights at the National Aeronautics and Space Administration, Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Williams, Vernon E.

    1994-01-01

    At a fundamental level, intellectual property is the core work product of a technical organization. The National Aeronautics and Space Administration (NASA), produces a variety of intellectual property including: patents, trademarks, data rights, copyright and rights associated with National Security. For a scientific organization to properly manage its work product it has to manage its intellectual property. This paper endeavors to describe how the intellectual property rights are generated and allocated at NASA. The author then goes on to discuss how the intellectual property might be managed to meet the objectives of program implementation, technology transfer and security.

  4. Intellectual Property in the Information Age.

    ERIC Educational Resources Information Center

    Gilbert, Steven W.; Lyman, Peter

    1989-01-01

    Nearly every academic practice is being transformed by information technology. The concept of "piracy," or "theft," presumes that ideas can still be treated as if they are property, and if so, that the rules controlling the movement of idea-properties can be enforced. (MLW)

  5. The increasing importance of Intellectual Property in Transfusion Medicine.

    PubMed

    Hardie, Ian D; Rooney, Catherine

    2011-08-01

    The Scottish National Blood Transfusion Service (SNBTS) originated in Edinburgh in the 1920's by dentist Jack Copland. Since that time the scope of Transfusion Medicine has broadened significantly to accommodate advances in technologies such as cell isolation, culture and manipulation. Many transfusion services, including SNBTS, now provide expertise both in the traditional field of blood transfusion and the newer, wider field of human cell (including 'adult' and embryonic stem cells) and tissue procurement and culture - in all the new science of "regenerative medicine". This paper describes the importance of Intellectual Property in the provision of Transfusion Medicine today and provides guidance on the management of Intellectual Property so that advances in the field have the best chance of successful translation into clinical practice.

  6. Sharing Research Data and Intellectual Property Law: A Primer

    PubMed Central

    Carroll, Michael W.

    2015-01-01

    Sharing research data by depositing it in connection with a published article or otherwise making data publicly available sometimes raises intellectual property questions in the minds of depositing researchers, their employers, their funders, and other researchers who seek to reuse research data. In this context or in the drafting of data management plans, common questions are (1) what are the legal rights in data; (2) who has these rights; and (3) how does one with these rights use them to share data in a way that permits or encourages productive downstream uses? Leaving to the side privacy and national security laws that regulate sharing certain types of data, this Perspective explains how to work through the general intellectual property and contractual issues for all research data. PMID:26313685

  7. Innovations and intellectual property: the case of genomic patenting.

    PubMed

    Jackson, Brian A

    2003-01-01

    In an effort to balance static and dynamic efficiency in the production and use of knowledge, societies institute intellectual property policies. In the United States, the patent system is a well-established mechanism to provide inventors with time-limited protection of new technologies in exchange for disclosure of information about their inventions. Emerging biotechnology, specifically the filing of patents on gene sequences, raises serious questions about whether the patent system is appropriately weighing societal costs and benefits in its grants of intellectual property protection. Gene sequences represent a hybrid case between discrete inventions and more general pieces of information that are useful for many, potentially very different, purposes. This information content in genes makes it possible for a patent on a gene to cover a wide range of possible technological applications and, as a result, be of unknown breadth when issued. This analysis explores the potential effect of these characteristics on future innovation in biotechnology.

  8. Sharing Research Data and Intellectual Property Law: A Primer.

    PubMed

    Carroll, Michael W

    2015-08-01

    Sharing research data by depositing it in connection with a published article or otherwise making data publicly available sometimes raises intellectual property questions in the minds of depositing researchers, their employers, their funders, and other researchers who seek to reuse research data. In this context or in the drafting of data management plans, common questions are (1) what are the legal rights in data; (2) who has these rights; and (3) how does one with these rights use them to share data in a way that permits or encourages productive downstream uses? Leaving to the side privacy and national security laws that regulate sharing certain types of data, this Perspective explains how to work through the general intellectual property and contractual issues for all research data.

  9. An overview of pharmaceutical cocrystals as intellectual property.

    PubMed

    Trask, Andrew V

    2007-01-01

    This review article focuses on the interaction among certain scientific, legal, and regulatory aspects of pharmaceutical crystal forms. The article offers an analysis of pharmaceutical cocrystals as patentable inventions by drawing upon recent scientific developments in the field. Several potential commercial advantages of pharmaceutical cocrystals are highlighted, and a number of recent court decisions involving salient issues are summarized. The article provides an outlook on how the developing field of cocrystallization may impact the pharmaceutical intellectual property landscape.

  10. Institutional Responses on Strengthened Intellectual Property Rights in Agriculture and Needs' Assessment on Intellectual Property Management of Public Research Institutions in Asian Developing Countries

    ERIC Educational Resources Information Center

    Payumo, Jane; Grimes, Howard

    2011-01-01

    Intellectual property rights (IPRs) are being introduced or strengthened in developing countries as a result of international agreements such as the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) of the World Trade Organization (WTO). This study conducted a web-based survey to gain perspective on the impact of IPRs to…

  11. Intellectual Property Is No Game: An Interview with James G. Gatto, JD.

    PubMed

    2012-12-01

    Copying within the games industry is reportedly widespread. Some people attribute this to the belief that this is just the way it is and has always been based on the notion that the "idea" for a game is not protectable. But as the game market grows, so too do the losses from copying suffered by game innovators. A contributing factor is that many game developers do not develop comprehensive strategies for protecting the valuable intellectual property that they create. In the following interview, Bill Ferguson, PhD, Editor of Games for Health Journal, discusses the hazards and ways to protect health game assets with intellectual property expert Jim Gatto, Leader of the Social Media, Entertainment & Technology Team at the respected law firm of Pillsbury Winthrop Shaw Pittman LLP.

  12. [Improving global access to new vaccines: intellectual property, technology transfer, and regulatory pathways].

    PubMed

    Crager, Sara Eve

    2015-01-01

    The 2012 World Health Assembly Global Vaccine Action Plan called for global access to new vaccines within 5 years of licensure. Current approaches have proven insufficient to achieve sustainable vaccine pricing within such a timeline. Paralleling the successful strategy of generic competition to bring down drug prices, a clear consensus is emerging that market entry of multiple suppliers is a critical factor in expeditiously bringing down prices of new vaccines. In this context, key target objectives for improving access to new vaccines include overcoming intellectual property obstacles, streamlining regulatory pathways for biosimilar vaccines, and reducing market entry timelines for developing-country vaccine manufacturers by transfer of technology and know-how. I propose an intellectual property, technology, and know-how bank as a new approach to facilitate widespread access to new vaccines in low- and middle-income countries by efficient transfer of patented vaccine technologies to multiple developing-country vaccine manufacturers.

  13. Improving Global Access to New Vaccines: Intellectual Property, Technology Transfer, and Regulatory Pathways

    PubMed Central

    2014-01-01

    The 2012 World Health Assembly Global Vaccine Action Plan called for global access to new vaccines within 5 years of licensure. Current approaches have proven insufficient to achieve sustainable vaccine pricing within such a timeline. Paralleling the successful strategy of generic competition to bring down drug prices, a clear consensus is emerging that market entry of multiple suppliers is a critical factor in expeditiously bringing down prices of new vaccines. In this context, key target objectives for improving access to new vaccines include overcoming intellectual property obstacles, streamlining regulatory pathways for biosimilar vaccines, and reducing market entry timelines for developing-country vaccine manufacturers by transfer of technology and know-how. I propose an intellectual property, technology, and know-how bank as a new approach to facilitate widespread access to new vaccines in low- and middle-income countries by efficient transfer of patented vaccine technologies to multiple developing-country vaccine manufacturers. PMID:25211753

  14. Improving global access to new vaccines: intellectual property, technology transfer, and regulatory pathways.

    PubMed

    Crager, Sara Eve

    2014-11-01

    The 2012 World Health Assembly Global Vaccine Action Plan called for global access to new vaccines within 5 years of licensure. Current approaches have proven insufficient to achieve sustainable vaccine pricing within such a timeline. Paralleling the successful strategy of generic competition to bring down drug prices, a clear consensus is emerging that market entry of multiple suppliers is a critical factor in expeditiously bringing down prices of new vaccines. In this context, key target objectives for improving access to new vaccines include overcoming intellectual property obstacles, streamlining regulatory pathways for biosimilar vaccines, and reducing market entry timelines for developing-country vaccine manufacturers by transfer of technology and know-how. I propose an intellectual property, technology, and know-how bank as a new approach to facilitate widespread access to new vaccines in low- and middle-income countries by efficient transfer of patented vaccine technologies to multiple developing-country vaccine manufacturers.

  15. Intellectual property education exemplified by the patents on the CRISPR/Cas9 system.

    PubMed

    Fan, Xiangyu; Liao, Guojian; Xie, Jianping

    2014-12-01

    With the accelerated globalization of the world economies, the role of intellectual property in the the competition is increasingly important. The universities are important base to instill the intellectual property awareness to the young generation. However, current model of intellectual property education cannot meet the needs of undergraduates. In this paper, we take the first patent issued for CRISPR/Cas9 system as a teaching example, and together with personal teaching experience in biomedicine related intellectual property, we propose a new way for intellectual property education which consists of two stages: enlightenment stage and in-depth training stage. In the former stage, we integrate the intellectual property education with the basic major courses. In the latter stage, students are encouraged to devote into intellectual property related career. This model can somehow solve the the current shortage of qualified teachers for biotechnology related intellectual property education and will facilitate the popularization of intellectual property in college students. Since genetics plays a pivotal role in biomedicine, this effort is illustrated by the novel genome editing technology based on the CRISPR/Cas9 system, which is one hotspot of recent studies. The trajectory of CRISPR/Cas9 from basic microbial genetics discovery to major tools for genome editing exeplified the essence of biomedicine related intellectual property education.

  16. Access to generic antiretrovirals: inequality, intellectual property law, and international trade agreements.

    PubMed

    Castro, Arachu; Westerhaus, Michael

    2007-01-01

    The governments of numerous low- and middle-income countries are currently instituting rules that strengthen changes in domestic intellectual property legislation, often made to conform to the mandates of "free" trade agreements signed with the United States. These measures frequently include intellectual property provisions that extend beyond the patent law standards agreed upon in recent World Trade Organization negotiations, which promised to balance the exigencies of public health and patent holders. In this paper, we analyze the concern that this augmentation of patent law standards will curtail access to essential medicines, particularly as they relate to the AIDS pandemic. We critically examine the potential threats posed by trade agreements vis-à-vis efforts to provide universal access to antiretroviral medications and contend that the conditioning of economic development upon the strengthening of intellectual property law demands careful attention when public health is at stake. Finally, we examine advocacy successes in challenging patent law and conclude that greater advocacy and policy strategies are needed to ensure the protection of global health in trade negotiations.

  17. Canada's Patented Medicines (Notice of Compliance) Proceedings and Intellectual Property.

    PubMed

    Bian, Henry; McCourt, Conor

    2015-01-08

    Canada's Patent Register is a tool created by the Patented Medicines (Notice of Compliance) Regulations to help innovators protect their inventions relating to pharmaceuticals. This tool exists at the intersection between the intellectual property and drug approval regimes. By listing a patent on the Patent Register, an innovator can prevent a generic manufacturer from entering the marketplace rather than having to wait for his or her patent to be infringed. This article provides information on the requirements for listing a patent on the Patent Register and an overview of how the Patent Medicines (Notice of Compliance) Regulations affect the drug approval process.

  18. Access and control of information and intellectual property

    NASA Astrophysics Data System (ADS)

    Lang, Gerald S.

    1996-03-01

    This paper introduces the technology of two pioneering patents for the secure distribution of information and intellectual property. The seminal technology has been used in the control of sensitive material such as medical records and imagery in distributed networks. It lends itself to the implementation of an open architecture access control system that provides local or remote user selective access to digital information stored on any computer system or storage medium, down to the data element, pixel, and sub-pixel levels. Use of this technology is especially suited for electronic publishing, health care records, MIS, and auditing.

  19. Intellectual Property Rights Protection in Peer to Peer Networks

    NASA Astrophysics Data System (ADS)

    Stylios, Georgios; Tsolis, Dimitrios

    Peer to Peer Networks are oftenly used by internet users to share and distribute digital content (images, audio and video) which is in most of cases protected by the Intellectual Property Rights (IPR) legislation. This fact threatens e-inclusion and Internet democracy as a whole as it forces organizations to block access to valuable content. This paper claims that IPR protection and P2P can be complementary. Specifically, a P2P infrastructure is presented which allows broad digital content exchange while on the same time supports data and copyright protection through watermarking technologies.

  20. Investigations regarding the evaluation of specific intellectual property production risks within Quality Management System

    NASA Astrophysics Data System (ADS)

    Pakocs, R.; Lupulescu, N. B.

    2016-11-01

    This paper is a theoretical research concerning methods for risk assessment of specific intellectual property production risks that are identified in the product achievement stage within the Quality Management System. In order to realize this, we will start by identifying the specific intellectual property production risks and by proposing some new calculating formulas for minimalizing their negative effects. The theoretical model proposed assessment of specific intellectual property production risks, will be realized based on 3 hypothetical situations. This study intends to reduce the intellectual property risks identified in the production process of commercial societies that have an industrial profile.

  1. 32 CFR 34.25 - Intellectual property developed or produced under awards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Intellectual property developed or produced under awards. 34.25 Section 34.25 National Defense Department of Defense OFFICE OF THE SECRETARY OF...-PROFIT ORGANIZATIONS Post-award Requirements Property Standards § 34.25 Intellectual property...

  2. Intellectual property rights and patents in perspective of Ayurveda.

    PubMed

    Chaudhary, Anand; Singh, Neetu

    2012-01-01

    Ayurveda is getting its due recognition as a rationale system of medicine worldwide despite the fact that medical and scientific fraternity of the globe has very strong opposite opinion regarding safety and efficacy of Ayurvedic medicines. Meanwhile, provisions of Intellectual Property Rights under World Intellectual Property Organization (WIPO) and Patents have attracted many individuals and organizations to explore possibilities of commercial benefits with Ayurvedic traditional knowledge. Although rules are not favoring to grant a patent on prior published knowledge, biopiracy managed grant of Patent on knowledge of Ayurvedic medicinal plants which has been successfully checked with references of data base of Traditional Knowledge Digital Library (TKDL). Current provisions of the Patent law of India are obstructive in nature for getting patent on Ayurvedic medicines. If we have to invite researchers from basic science to ensure quality, safety and efficacy of Ayurvedic medicines, there is an urgent need to amend laws of patent with pragmatic promotional policies. This will encourage more patents on numerous pharmaceutical, nutraceutical and cosmaceutical products based on Ayurveda. As every action of today's world is based on economic criteria so why stakeholders of Ayurveda should be deprived of it. New inventions would drive acceptance of Ayurveda as a global system of medicine.

  3. Intellectual property rights and patents in perspective of Ayurveda

    PubMed Central

    Chaudhary, Anand; Singh, Neetu

    2012-01-01

    Ayurveda is getting its due recognition as a rationale system of medicine worldwide despite the fact that medical and scientific fraternity of the globe has very strong opposite opinion regarding safety and efficacy of Ayurvedic medicines. Meanwhile, provisions of Intellectual Property Rights under World Intellectual Property Organization (WIPO) and Patents have attracted many individuals and organizations to explore possibilities of commercial benefits with Ayurvedic traditional knowledge. Although rules are not favoring to grant a patent on prior published knowledge, biopiracy managed grant of Patent on knowledge of Ayurvedic medicinal plants which has been successfully checked with references of data base of Traditional Knowledge Digital Library (TKDL). Current provisions of the Patent law of India are obstructive in nature for getting patent on Ayurvedic medicines. If we have to invite researchers from basic science to ensure quality, safety and efficacy of Ayurvedic medicines, there is an urgent need to amend laws of patent with pragmatic promotional policies. This will encourage more patents on numerous pharmaceutical, nutraceutical and cosmaceutical products based on Ayurveda. As every action of today's world is based on economic criteria so why stakeholders of Ayurveda should be deprived of it. New inventions would drive acceptance of Ayurveda as a global system of medicine. PMID:23049179

  4. The right to health and medicines: the case of recent multilateral negotiations on public health, innovation and intellectual property.

    PubMed

    Velasquez, German

    2014-08-01

    The negotiations of the intergovernmental group known as the 'IGWG', undertaken by the Member States of the WHO, were the result of a deadlock in the World Health Assembly held in 2006 where the Member States of the WHO were unable to reach an agreement on what to do with the 60 recommendations in the report on 'Public Health, Innovation and Intellectual Property Rights submitted to the Assembly in the same year by a group of experts designated by the Director General of the WHO. The result of these negotiations was the 'Global strategy and plan of action on public health, innovation and intellectual property' which was approved by the World Health Assembly in 2008. The intention of the Global Strategy and Plan of Action (GSPOA) which was produced by the IGWG was to substantially reform the pharmaceuticals' research and development system in view of the findings that this system, whose purpose is to produce medicines for diseases which affect the greater part of the world population which lives in developing countries, had failed. The intellectual property rights imposed by the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) and the recent trade agreements could become one of the main obstacles to access to medicines. The GSPOA makes a critical analysis of this reality, and opens the door to searching for new solutions to this problem.

  5. Mediating Haptic Exploratory Strategies in Children Who Have Visual Impairment and Intellectual Disabilities

    ERIC Educational Resources Information Center

    McLinden, M.

    2012-01-01

    This article provides a synthesis of literature pertaining to the development of haptic exploratory strategies in children who have visual impairment and intellectual disabilities. The information received through such strategies assumes particular significance for these children, given the restricted information available through their visual…

  6. 31 CFR 515.528 - Certain transactions with respect to blocked foreign intellectual property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Certain transactions with respect to blocked foreign intellectual property. 515.528 Section 515.528 Money and Finance: Treasury Regulations... Certain transactions with respect to blocked foreign intellectual property. (a) The following...

  7. 31 CFR 515.527 - Certain transactions with respect to United States intellectual property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Certain transactions with respect to United States intellectual property. 515.527 Section 515.527 Money and Finance: Treasury Regulations... Certain transactions with respect to United States intellectual property. (a)(1) Transactions related...

  8. 31 CFR 515.528 - Certain transactions with respect to blocked foreign intellectual property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Certain transactions with respect to blocked foreign intellectual property. 515.528 Section 515.528 Money and Finance: Treasury Regulations... Certain transactions with respect to blocked foreign intellectual property. (a) The following...

  9. 6 CFR 25.10 - Confidentiality and protection of Intellectual Property.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... protection of Intellectual Property. (a) General. The Secretary, in consultation with the Office of... 6 Domestic Security 1 2011-01-01 2011-01-01 false Confidentiality and protection of Intellectual Property. 25.10 Section 25.10 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE...

  10. 31 CFR 515.527 - Certain transactions with respect to United States intellectual property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Certain transactions with respect to United States intellectual property. 515.527 Section 515.527 Money and Finance: Treasury Regulations... Certain transactions with respect to United States intellectual property. (a)(1) Transactions related...

  11. The Public and Private Domains: Intellectual Property Rights in Traditional Knowledge.

    ERIC Educational Resources Information Center

    Dutfield, Graham

    2000-01-01

    Defines traditional knowledge and its uses and argues that intellectual property law contains an in-built bias that protects the intangible assets of companies while failing to recognize traditional knowledge as protectable subject matter. Discusses the globalization of intellectual property rights and the unjust situation for indigenous people.…

  12. Indigenous Knowledge and Intellectual Property Rights: Confronting Modern Norms to Promote Sustainability

    ERIC Educational Resources Information Center

    Godbole-Chaudhuri, Pragati; Srikantaiah, Deepa; van Fleet, Justin

    2008-01-01

    The global proliferation of intellectual property rights (IPRs), most recently through the World Trade Organization's Trade Related Aspects of Intellectual Property Rights (TRIPS) Agreement, poses a grave threat for Indigenous knowledge systems. There is an increasing amount of "piracy" of Indigenous knowledge, whereby corporations and scientists…

  13. Understanding Copyright and Intellectual Property in the Digital Age: Guidelines for Teacher Educators and Their Students.

    ERIC Educational Resources Information Center

    Ludlow, Barbara L.

    2003-01-01

    This article examines federal law and institutional policies relevant to copyright and intellectual property as they apply to faculty and students in teacher education programs in special education. Copyright law and intellectual property are explained, including changes associated with the Technology, Education, and Copyright Harmonization…

  14. College Writing, Identification, and the Production of Intellectual Property: Voices from the Stanford Study of Writing

    ERIC Educational Resources Information Center

    Lunsford, Andrea A.; Fishman, Jenn; Liew, Warren M.

    2013-01-01

    When, why, and how do college students come to value their writing as intellectual property? How do their conceptions of intellectual property reflect broader understandings and personal engagements with concepts of authorship, collaboration, identification, and capital? We address these questions based on findings from the Stanford Study of…

  15. Changing drug markets under new intellectual property regimes: the view from Central America.

    PubMed

    Godoy, Angelina Snodgrass; Cerón, Alejandro

    2011-07-01

    The intellectual property rules inscribed in the Central American Free Trade Agreement have generated concern about access to medicines. We examined the implementation of the new intellectual property regime by tracking the policies and practices in place across 4 Central American countries. Although all 4 were responding to the same requirements under the agreement, their implementation of intellectual property rules differed. Not only were institutional practices different, but the lists of drugs to which intellectual property protection was applied varied in both volume and content. We also found that even without the influence of intellectual property, drug pricing in the region was often unpredictable and that lower cost was not the only motivation driving governments' purchasing decisions.

  16. [On the necessity of intellectual property rights involving standardization of acupuncture and moxibustion therapies].

    PubMed

    Dong, Guo-Feng; Wu, Xiao-Dong; Han, Yan-Jing; Wang, Xin; Wang, Jun-Wen

    2014-08-01

    In the process of working out and implementing standardization of acupuncture-moxibustion (acu-moxi) therapy, the issue of intellectual property rights has been frequently involved. Whether is the standardization inevitably involved in intellectual property rights? A reasonable answer to this question is definitely of important realistic guiding value and significance for acu-moxi standardization work. For this reason, authors of the present paper sum up historical development of correlation between acu-moxi standardization and intellectual property rights, and fully analyze the related causes under the conditions of knowledge economy from 1) increasing protection of acu-moxi intellectual property rights, 2) intrinsic requirements for raising the standardization level of acu-moxi, 3) profits drive of the intellectual property rights owners, and 4) increasing impetuous international economic trade competition.

  17. Changing Drug Markets Under New Intellectual Property Regimes: The View From Central America

    PubMed Central

    Cerón, Alejandro

    2011-01-01

    The intellectual property rules inscribed in the Central American Free Trade Agreement have generated concern about access to medicines. We examined the implementation of the new intellectual property regime by tracking the policies and practices in place across 4 Central American countries. Although all 4 were responding to the same requirements under the agreement, their implementation of intellectual property rules differed. Not only were institutional practices different, but the lists of drugs to which intellectual property protection was applied varied in both volume and content. We also found that even without the influence of intellectual property, drug pricing in the region was often unpredictable and that lower cost was not the only motivation driving governments' purchasing decisions. PMID:21566033

  18. Biotechnology-Related Intellectual Property Law of Iran

    PubMed Central

    Rasekh, Mohammad

    2009-01-01

    In this study, an attempt has been made to expound the Iranian law of intellectual property in relation to biotechnology. The most important themes studied are patents, industrial designs and trade marks. The latest relevant piece of legislation concerning the subject matters was passed in March 2008. However, the history of laws and regulations in this field goes back to early twentieth century (i.e. 1925). In this review, on the basis of the latest law passed in 2008, the topics explored are the responsible authority, patentable items and criteria, excluded items, registration procedure, rights conferred and sanctions. At the end, an attempt is made to put forward a few points as an analysis of the above Law from a critical point of view. PMID:23407745

  19. Does Intellectual Property Restrict Output? An Analysis of Pharmaceutical Markets.

    PubMed

    Lakdawalla, Darius; Philipson, Tomas

    2012-02-01

    Standard normative analysis of intellectual property focuses on the balance between incentives for research and the static welfare costs of reduced price-competition from monopoly. However, static welfare loss from patents is not universal. While patents restrict price competition, they may also provide static welfare benefits by improving incentives for marketing, which is a form of non-price competition. We show theoretically how stronger marketing incentives mitigate, and can even offset, the static costs of monopoly pricing. Empirical analysis in the pharmaceutical industry context suggests that, in the short-run, patent expirations reduce consumer welfare as a result of decreased marketing effort. In the long-run, patent expirations do benefit consumers, but by 30% less than would be implied by the reduction in price alone. The social value of monopoly marketing to consumers alone is roughly on par with its costs to firms.

  20. Recalibrating intellectual property rights to enhance translational research collaborations.

    PubMed

    Bubela, Tania; FitzGerald, Garret A; Gold, E Richard

    2012-02-22

    Multisectoral collaborative models for drug and therapeutic research and development (R&D) are emerging, requiring a recalibration of how intellectual property rights (IPRs) are used. Although these models appear promising, little study has been conducted on the optimal blend of sharing and exclusion as mediated through the proactive use or nonuse of IPRs. This Commentary is a call for a combination of theoretical and empirical analyses to build a comprehensive understanding of the interplay between formal IP laws, institutions that administer and manage IPRs, and the use of IPRs in practice to better construct and manage collaborations. Such analyses require outcome metrics formulated to measure the success of therapeutic outcomes and to capture the complexity of a highly networked R&D environment.

  1. Genome editing: intellectual property and product development in plant biotechnology.

    PubMed

    Schinkel, Helga; Schillberg, Stefan

    2016-07-01

    Genome editing is a revolutionary technology in molecular biology. While scientists are fascinated with the unlimited possibilities provided by directed and controlled changes in DNA in eukaryotes and have eagerly adopted such tools for their own experiments, an understanding of the intellectual property (IP) implications involved in bringing genome editing-derived products to market is often lacking. Due to the ingenuity of genome editing, the time between new product conception and its actual existence can be relatively short; therefore knowledge about IP of the various genome editing methods is relevant. This point must be regarded in a national framework as patents are instituted nationally. Therefore, when designing scientific work that could lead to a product, it is worthwhile to consider the different methods used for genome editing not only for their scientific merits but also for their compatibility with a speedy and reliable launch into the desired market.

  2. Intellectual property rights and detached human body parts.

    PubMed

    Pila, Justine

    2014-01-01

    This paper responds to an invitation by the editors to consider whether the intellectual property (IP) regime suggests an appropriate model for protecting interests in detached human body parts. It begins by outlining the extent of existing IP protection for body parts in Europe, and the relevant strengths and weaknesses of the patent system in that regard. It then considers two further species of IP right of less obvious relevance. The first are the statutory rights of ownership conferred by domestic UK law in respect of employee inventions, and the second are the economic and moral rights recognised by European and international law in respect of authorial works. In the argument made, both of these species of IP right may suggest more appropriate models of sui generis protection for detached human body parts than patent rights because of their capacity better to accommodate the relevant public and private interests in respect of the same.

  3. Does Intellectual Property Restrict Output? An Analysis of Pharmaceutical Markets*

    PubMed Central

    Lakdawalla, Darius; Philipson, Tomas

    2013-01-01

    Standard normative analysis of intellectual property focuses on the balance between incentives for research and the static welfare costs of reduced price-competition from monopoly. However, static welfare loss from patents is not universal. While patents restrict price competition, they may also provide static welfare benefits by improving incentives for marketing, which is a form of non-price competition. We show theoretically how stronger marketing incentives mitigate, and can even offset, the static costs of monopoly pricing. Empirical analysis in the pharmaceutical industry context suggests that, in the short-run, patent expirations reduce consumer welfare as a result of decreased marketing effort. In the long-run, patent expirations do benefit consumers, but by 30% less than would be implied by the reduction in price alone. The social value of monopoly marketing to consumers alone is roughly on par with its costs to firms. PMID:25221349

  4. Intellectual Property: a powerful tool to develop biotech research

    PubMed Central

    Giugni, Diego; Giugni, Valter

    2010-01-01

    Summary Today biotechnology is perhaps the most important technology field because of the strong health and food implications. However, due to the nature of said technology, there is the need of a huge amount of investments to sustain the experimentation costs. Consequently, investors aim to safeguard as much as possible their investments. Intellectual Property, and in particular patents, has been demonstrated to actually constitute a powerful tool to help them. Moreover, patents represent an extremely important means to disclose biotechnology inventions. Patentable biotechnology inventions involve products as nucleotide and amino acid sequences, microorganisms, processes or methods for modifying said products, uses for the manufacture of medicaments, etc. There are several ways to protect inventions, but all follow the three main patentability requirements: novelty, inventive step and industrial application. PMID:21255349

  5. Intellectual property rights and traditional medicine: policy dilemmas at the interface.

    PubMed

    Timmermans, Karin

    2003-08-01

    Traditional medicines play an important role in the provision of health care in many developing countries. Their use is also significant in developed countries, increasing their commercial value. Several 'high-profile' cases of patenting of traditional medicines, without consent from or compensation to their holders, have further focussed attention on their importance. Traditional medicine usually involves biological resources and the knowledge of local and indigenous peoples and/or healers regarding their medicinal use; thus, it is interlinked with biodiversity conservation and indigenous peoples' rights over their knowledge and resources. At this multi-faceted interface, complex ethical questions arise. This article provides an overview and discussion of key issues, dilemmas and challenges. It points to possible modifications and at ways to devise new forms of intellectual property ownership that may better suit the needs of those who seek to protect traditional medicine. Yet it also questions whether such protection, which may restrict access, is the preferred option. While intellectual property protection for traditional medicines has multiple and diverse objectives, the priorities are often not clear and the strategies which could be deployed may interfere with each other, as well as with the prioritization of objectives. This is further aggravated by differences in stakeholders' concepts on ownership of knowledge and by uncertain or paradoxical effects of some potentially useful strategies. Thus, policymakers should address the multiple, multi-layered issues and questions, and try to develop a range of solutions in order to address and balance the various objectives and interests.

  6. 26 CFR 1.6050L-2 - Information returns by donees relating to qualified intellectual property contributions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... qualified intellectual property contributions. 1.6050L-2 Section 1.6050L-2 Internal Revenue INTERNAL REVENUE... § 1.6050L-2 Information returns by donees relating to qualified intellectual property contributions... receives or accrues net income during a taxable year from any qualified intellectual property...

  7. Strategy Instruction versus Direct Instruction in the Education of Young Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Blik, H.; Harskamp, E. G.; Naayer, H. M.

    2016-01-01

    In the Netherlands, students with intellectual disabilities (ID) attend practical education (PE). Teachers generally use demonstration as a form of direct instruction (DI) and students have difficulty working independently. Strategy instruction (SI) is a question-answer-based method that stimulates students' autonomy by getting them to verbalize…

  8. "A Kid Way": Strategies for Including Classmates with Learning or Intellectual Disabilities

    ERIC Educational Resources Information Center

    Nowicki, Elizabeth A.; Brown, Jason D.

    2013-01-01

    Thirty-six children between 9 and 12 years of age were invited to share their ideas on how to socially include classmates with learning or intellectual disabilities at school. Participants generated 80 strategies which were categorized into seven major themes. Thematic categories focused on the need for teachers to intervene in academic and social…

  9. Shufflegolf: Teaching Golf Strategies and Etiquette to Young Children and Learners with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Kozub, Francis M.

    2010-01-01

    The purpose of this article is to share a unique curricular idea with physical educators interested about adding golf concepts to their curriculum. The focus is on a modified golf game that helps teach tactics, strategies, rules, and etiquette to young learners and those with intellectual disabilities. The specific content for this unit focuses on…

  10. Effects of the TIP Strategy on Problem Solving Skills of Young Adults with Intellectual Disability

    ERIC Educational Resources Information Center

    Hua, Youjia; Woods-Groves, Suzanne; Kaldenberg, Erica R.; Lucas, Kristin G.; Therrien, William J.

    2015-01-01

    The purpose of the study was to investigate the effectiveness of teaching a three-step cognitive strategy (TIP) using the schema broadening procedures on functional mathematical problem solving skills of young adults with intellectual disability (ID). We randomly assigned 14 learners with ID to the control and experimental group before the…

  11. Cognitive Strategy Instruction for Functional Mathematical Skill: Effects for Young Adults with Intellectual Disability

    ERIC Educational Resources Information Center

    Hua, Youjia; Morgan, Benjamin S. T.; Kaldenberg, Erica R.; Goo, Minkowan

    2012-01-01

    This study assessed the effectiveness of a three-step cognitive strategy (TIP) for calculating tip and total bill for young adults with intellectual disability. In the context of pre- and post-test nonequivalent-groups design, 10 students from a postsecondary education program for individuals with disabilities participated in the study. A teacher…

  12. Mental Calculation Strategies of a Student Attending a Special School for the Intellectually Disabled

    ERIC Educational Resources Information Center

    Rumiati, Rumi; Wright, Robert J.

    2014-01-01

    Pat was a 19-year-old attending a Special School for the Intellectually Disabled in Indonesia. She was interviewed by the first author regarding her mental calculation strategies when solving 1- and 2-digit addition and subtraction problems. Results indicate that she was able to see ten as a unit composed of ten ones and was facile in using…

  13. Siblings' Mediated Learning Strategies in Families with and without Children with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Tzuriel, David; Hanuka-Levy, Dikla

    2014-01-01

    Dyads of siblings in which the younger sibling had an intellectual disability (ID, n = 25) were videotaped interacting. The ID group was compared with typically developing sibling dyads matched on mental age (n = 25) and chronological age (n = 25). We observed the mediation strategies, activation, and antimediation behaviors of older siblings and…

  14. Effects of the Paraphrasing Strategy on Expository Reading Comprehension of Young Adults with Intellectual Disability

    ERIC Educational Resources Information Center

    Hua, Youjia; Woods-Groves, Suzanne; Ford, Jeremy W.; Nobles, Kelly A.

    2014-01-01

    The purpose of the study was to investigate the effectiveness of teaching a three-step paraphrasing strategy on expository reading comprehension of young adults with intellectual disability. Ten learners from a postsecondary education program for individuals with disability participated in the study. They were randomly assigned to the control and…

  15. 26 CFR 1.6050L-2 - Information returns by donees relating to qualified intellectual property contributions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... qualified intellectual property contributions. 1.6050L-2 Section 1.6050L-2 Internal Revenue INTERNAL REVENUE...) Information Returns § 1.6050L-2 Information returns by donees relating to qualified intellectual property...), that receives or accrues net income during a taxable year from any qualified intellectual...

  16. Transfer of Teaching Materials between Universities: Where Is the Boundary between Legitimate Transaction and Violation of Moral Intellectual Property Rights?

    ERIC Educational Resources Information Center

    Maiwald, Matthias; Harrington, Kathy

    2012-01-01

    Intellectual property rights have various facets. The best-known one is copyright, enabling the owner to legally utilise intellectual materials. However, there is a separate set of legal entitlements, termed moral intellectual property rights. The purpose of these is to prevent false attribution, damage to an author's reputation and some forms of…

  17. Intellectual property rights, market competition and access to affordable antiretrovirals.

    PubMed

    Pascual, Fernando

    2014-01-01

    The number of patients receiving antiretroviral therapy (ART) has increased from around half a million in 2003 to almost 10 million in only 10 years, and will continue to increase in the coming years. Over 16 million more are eligible to start ART according to the last World Health Organization (WHO) guidelines. The demand is also switching from the less expensive antiretrovirals (ARVs) that allowed such scale-up to newer more expensive ones with fewer side effects or those that can be used by people who have developed resistance to first-line treatment. However, patents on these new drugs can delay robust generic competition and, consequently, price reduction made possible by economies of scale. Various ways to address this issue have been envisaged or implemented, including the use of the flexibilities available under the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), systematic widespread voluntary licensing, of which the Medicines Patent Pool (MPP) is an example, and the application of different prices in different countries, called tiered pricing. This paper helps explain the impact of patents on market competition for ARVs and analyses various approaches available today to minimize this impact.

  18. Plants genetic manipulation: an approach from intellectual property.

    PubMed

    Ruiz, Anisley Negrin; Rivero, Lazaro Pino

    2013-01-01

    From the end of the 20th century the Biotechnology has experimented a vertiginous advance so far, putting on approval concepts like bio-security and bioethics; becoming this way, the work with the genome of the plants, in a matter is worthy to be reconsidered by the juridical mark that regulates it, in order to moderate the norm to the new scientific context. The Intellectual Property, when recognizing patent rights on products that have incorporate biological material, as well as to the obtainer about the new vegetable varieties obtained, could mean an obstacle that impedes or hinder the access from the society to that product or that variety. In the same way is worthy of consideration, the fact that such products or varieties can be a risk for the human health or the Environment, and a monopoly of commercial exploitation for the holder of the patent or of the obtainer certificate. This study is about this topic; and valuation about aspects of Biotechnology related with the genome of the plants and their juridical protection, in the international sand as well in Cuba.

  19. NASA Intellectual Property Negotiation Practices and their Relationship to Quantitative Measures of Technology Transfer

    NASA Technical Reports Server (NTRS)

    Bush, Lance B.

    1997-01-01

    In the current political climate NASA must be able to show reliable measures demonstrating successful technology transfer. The currently available quantitative data of intellectual property technology transfer efforts portray a less than successful performance. In this paper, the use of only quantitative values for measurement of technology transfer is shown to undervalue the effort. In addition, NASA's current policy in negotiating intellectual property rights results in undervalued royalty rates. NASA has maintained that it's position of providing public good precludes it from negotiating fair market value for its technology and instead has negotiated for reasonable cost in order to recover processing fees. This measurement issue is examined and recommendations made which include a new policy regarding the intellectual property rights negotiation, and two measures to supplement the intellectual property measures.

  20. 15 CFR 295.8 - Intellectual property rights; publication of research results.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... derivative works, perform publicly and display publicly, and for data other than computer software to... intellectual property owned and developed by any business or joint research and development venture...

  1. Experimental investigations on the basis for intellectual property rights.

    PubMed

    Fast, Anne A; Olson, Kristina R; Mandel, Gregory N

    2016-08-01

    Lay people routinely misunderstand or do not obey laws protecting intellectual property (IP), leading to a variety of (largely unsuccessful) efforts by policymakers, IP owners, and researchers to change those beliefs and behaviors. The current work tests a new approach, inquiring whether lay people's views about IP protection can be modified by arguments concerning the basis for IP rights. Across 2 experiments, 572 adults (recruited through Amazon Mechanical Turk) read 1 of 6 arguments about the basis for IP protection (incentives, natural rights, expressive rights, plagiarism, commons, or no argument). Participants then reported their general support for IP protection. Participants also reported their evaluations of 2 scenarios that involved infringement of IP rights, including cases in which there were mitigating experiences (e.g., the copier acknowledged the original source), and completed several demographic questions. Three primary findings emerged: (a) exposure to the importance of the public commons (and to a lesser extent, exposure to the argument that plagiarism is the basis of IP protection) led participants to become less supportive of IP protection than the incentives, natural rights, expressive rights, and control conditions; (b) people believed that infringement was more acceptable if the infringer acknowledged the original creator of the work; and (c) older adults and women were especially likely to see infringement as problematic. These findings illustrate several ways in which lay beliefs are at odds with legal doctrine, and suggest that people's views about IP protection can be shaped in certain ways by learning the basis for IP rights. (PsycINFO Database Record

  2. "A kid way": strategies for including classmates with learning or intellectual disabilities.

    PubMed

    Nowicki, Elizabeth A; Brown, Jason D

    2013-08-01

    Thirty-six children between 9 and 12 years of age were invited to share their ideas on how to socially include classmates with learning or intellectual disabilities at school. Participants generated 80 strategies which were categorized into seven major themes. Thematic categories focused on the need for teachers to intervene in academic and social situations, child-to-child instructional strategies, being supportive, focusing on similarities between children with and without disabilities, modelling appropriate behaviors and intervening in negative interactions, structured inclusive activities, and noninclusive activities. Participants were aware of the challenges experienced by classmates with disabilities, and recognized the need to work with classmates and teachers towards the social inclusion of children with intellectual and learning disabilities. Educational implications are addressed.

  3. Remote Memory Access Protocol Target Node Intellectual Property

    NASA Technical Reports Server (NTRS)

    Haddad, Omar

    2013-01-01

    The MagnetoSpheric Multiscale (MMS) mission had a requirement to use the Remote Memory Access Protocol (RMAP) over its SpaceWire network. At the time, no known intellectual property (IP) cores were available for purchase. Additionally, MMS preferred to implement the RMAP functionality with control over the low-level details of the design. For example, not all the RMAP standard functionality was needed, and it was desired to implement only the portions of the RMAP protocol that were needed. RMAP functionality had been previously implemented in commercial off-the-shelf (COTS) products, but the IP core was not available for purchase. The RMAP Target IP core is a VHDL (VHSIC Hardware Description Language description of a digital logic design suitable for implementation in an FPGA (field-programmable gate array) or ASIC (application-specific integrated circuit) that parses SpaceWire packets that conform to the RMAP standard. The RMAP packet protocol allows a network host to access and control a target device using address mapping. This capability allows SpaceWire devices to be managed in a standardized way that simplifies the hardware design of the device, as well as the development of the software that controls the device. The RMAP Target IP core has some features that are unique and not specified in the RMAP standard. One such feature is the ability to automatically abort transactions if the back-end logic does not respond to read/write requests within a predefined time. When a request times out, the RMAP Target IP core automatically retracts the request and returns a command response with an appropriate status in the response packet s header. Another such feature is the ability to control the SpaceWire node or router using RMAP transactions in the extended address range. This allows the SpaceWire network host to manage the SpaceWire network elements using RMAP packets, which reduces the number of protocols that the network host needs to support.

  4. Benchmarking progress in tackling the challenges of intellectual property, and access to medicines in developing countries.

    PubMed

    Musungu, Sisule F

    2006-05-01

    The impact of intellectual property protection in the pharmaceutical sector on developing countries has been a central issue in the fierce debate during the past 10 years in a number of international fora, particularly the World Trade Organization (WTO) and WHO. The debate centres on whether the intellectual property system is: (1) providing sufficient incentives for research and development into medicines for diseases that disproportionately affect developing countries; and (2) restricting access to existing medicines for these countries. The Doha Declaration was adopted at WTO in 2001 and the Commission on Intellectual Property, Innovation and Public Health was established at WHO in 2004, but their respective contributions to tackling intellectual property-related challenges are disputed. Objective parameters are needed to measure whether a particular series of actions, events, decisions or processes contribute to progress in this area. This article proposes six possible benchmarks for intellectual property-related challenges with regard to the development of medicines and ensuring access to medicines in developing countries.

  5. Benchmarking progress in tackling the challenges of intellectual property, and access to medicines in developing countries.

    PubMed Central

    Musungu, Sisule F.

    2006-01-01

    The impact of intellectual property protection in the pharmaceutical sector on developing countries has been a central issue in the fierce debate during the past 10 years in a number of international fora, particularly the World Trade Organization (WTO) and WHO. The debate centres on whether the intellectual property system is: (1) providing sufficient incentives for research and development into medicines for diseases that disproportionately affect developing countries; and (2) restricting access to existing medicines for these countries. The Doha Declaration was adopted at WTO in 2001 and the Commission on Intellectual Property, Innovation and Public Health was established at WHO in 2004, but their respective contributions to tackling intellectual property-related challenges are disputed. Objective parameters are needed to measure whether a particular series of actions, events, decisions or processes contribute to progress in this area. This article proposes six possible benchmarks for intellectual property-related challenges with regard to the development of medicines and ensuring access to medicines in developing countries. PMID:16710545

  6. Information Wants To Be Shared: An Alternative Framework for Approaching Intellectual Property Disputes in an Information Age.

    ERIC Educational Resources Information Center

    Tavani, Herman T.

    2002-01-01

    Discusses the debate over intellectual property rights for digital media. Topics include why intellectual property should be protected; the evolution of copyright law; fair use doctrine; case studies; the philosophical theories of property, including labor theory, utilitarian theory, and personality theory; natural law theory; the social role of…

  7. New Technologies and Intellectual Property: An Economic Analysis. A Rand Note N-2601-NSF.

    ERIC Educational Resources Information Center

    Besen, Stanley M.

    This report examines how new information and communications technology may affect the economic system in which knowledge-based products and services are created, produced, packaged, distributed, delivered, and used. The following issues are considered: (1) the economic basis for the system of property rights in intellectual property, copyrights,…

  8. Intellectual property rights related to the genetically modified glyphosate tolerant soybeans in Brazil.

    PubMed

    Rodrigues, Roberta L; Lage, Celso L S; Vasconcellos, Alexandre G

    2011-06-01

    The present work analyzes the different modalities of protection of the intellectual creations in the biotechnology agricultural field. Regarding the Brazilian legislations related to the theme (the Industrial Property Law - no. 9. 279/96 and the Plant Variety Protection Law - no. 9. 456/97), and based in the international treaties signed by Brazil, the present work points to the inclusions of each of them, as well as to their interfaces using as reference the case study of glyphosate tolerant genetically modified soybean. For this case study, Monsanto's pipelines patents were searched and used to analyze the limits of patent protection in respect to others related to the Intellectual Property (IP) laws. Thus, it was possible to elucidate the complex scenario of the Intellectual Property of the glyphosate tolerant soybeans, since for the farmer it is hard to correlate the royalties payment with the IP enterprise's rights.

  9. The Management Of Intellectual Property In A Romanian State University Where Research Represents A Strength

    NASA Astrophysics Data System (ADS)

    Tîţu, Aurel Mihail; Oprean, Constantin; Răulea, Andreea Simina

    2015-07-01

    The transition to the knowledge-based economy and society requires adaptation to constant change that implies intellectual property as a multidimensional concept that continually leaves its mark on generations contributing to their well-being in obvious and undeniable ways. The main objective of this article was to assess the present level of the management of intellectual property in a state university in Romania displaying their strengths and weaknesses. The overall objective of the work is to analyze the state of the art in a Romanian state university in order to find solutions to the current problems that the Romanian scientific environment is facing. The conclusions drawn in the study converge in directions and proposals for improving the way in which the intellectual property is regarded and its management in the state universities of Romania.

  10. [Research on basic questions of intellectual property rights of acupuncture and moxibustion].

    PubMed

    Dong, Guo-Feng; Wu, Xiao-Dong; Han, Yan-Jing; Meng, Hong; Wang, Xin

    2011-12-01

    Along with the modernization and internationalization of acupuncture-moxibustion (acu-moxibustion), the issue of intellectual property rights has been becoming prominent and remarkable increasingly. In the present paper, the authors explain the basic issues of acu-moxibustion learning from the concept, scope, subject, object, contents and acquisition way of intellectual property rights. To make clear these questions will help us inherit and carry forward the existing civilization achievements of acu-moxibustion, and unceasingly bring forth new ideas and further improvement in clinical application, so as to serve the people's health in a better way.

  11. Siblings' mediated learning strategies in families with and without children with intellectual disabilities.

    PubMed

    Tzuriel, David; Hanuka-Levy, Dikla

    2014-11-01

    Dyads of siblings in which the younger sibling had an intellectual disability (ID, n  =  25) were videotaped interacting. The ID group was compared with typically developing sibling dyads matched on mental age (n  =  25) and chronological age (n  =  25). We observed the mediation strategies, activation, and antimediation behaviors of older siblings and younger siblings' responsiveness to mediation. Mediation strategies were analyzed by the Observation of Mediation Interaction scale. The ID group scored highest on mediation strategies and lowest on activation and antimediation behaviors. Younger siblings' responsiveness to mediation was highest among the ID group. Mediation for Intentionality and Reciprocity and Meaning were positively associated with the verbal responsiveness of the younger siblings. Activation and antimediation behaviors were negatively associated with the verbal responsiveness.

  12. Library Faculty Publishing and Intellectual Property Issues: A Survey of Attitudes and Awareness

    ERIC Educational Resources Information Center

    Carter, Howard; Snyder, Carolyn A.; Imre, Andrea

    2007-01-01

    Researchers from Southern Illinois University Carbondale (SIUC) surveyed faculty members from 10 academic research libraries to learn about scholarly publishing activities, attitudes, and policies. Areas of special interest included the effect of publishers' intellectual property policies and institutional promotion and tenure processes on library…

  13. Intellectual Property and Aboriginal People: A Working Paper = Propriete intellectuelle et Autochtones: Document de travail.

    ERIC Educational Resources Information Center

    Brascoupe, Simon; Endemann, Karin

    Written in English and French, this paper outlines current Canadian intellectual property legislation as it relates to Aboriginal people in Canada, and provides a general review of the implications and limitations of this legislation for protecting the traditional knowledge of Aboriginal people. An initial discussion of Aboriginal perspectives…

  14. Research on Intellectual Property Right Problems of Peer-to-Peer Networks.

    ERIC Educational Resources Information Center

    Dong, Ying; Li, Mingshu; Chen, Meizhang; Zheng, Shengli

    2002-01-01

    Discusses digital intellectual property rights relating to peer-to-peer networks, using Napster as an example. Suggests anti-piracy solutions to prevent litigation and considers how libraries can develop potential service models using peer-to-peer networks, including the development of personal libraries on the Internet, interlibrary loan,…

  15. Curriculum, Intellectual Property Rights and Open Educational Resources in British Universities--and Beyond

    ERIC Educational Resources Information Center

    Hawkridge, David; Armellini, Alejandro; Nikoi, Samuel; Rowlett, Tania; Witthaus, Gabi

    2010-01-01

    Is the curriculum in British universities being influenced by decisions about ownership of intellectual property rights (IPR) in "open educational resources" (OERs) that are available online under Creative Commons licenses, free of charge? This paper provides the context for, describes and analyses three significant examples in British…

  16. Curbing International Piracy of Intellectual Property. Policy Options for a Major Exporting Country.

    ERIC Educational Resources Information Center

    Hoffman, Gary M.; Marcou, George T.

    This report of the International Piracy Project addresses three major topics: (1) The Costs and Complications of Piracy; (2) Rights Enforcement Today; and (3) Policy Options for Curbing Piracy. The first section discusses piracy of copyrights, patents, and other intellectual property, including economic losses and damage to the finances and…

  17. Finding a Balance: Computer Software, Intellectual Property and the Challenge of Technological Change.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Office of Technology Assessment.

    This report, prepared by the Office of Technological Assessment (OTA) in response to a request from the House Committee on the Judiciary, examines the rapid and complex technological changes and trends in computer software technologies and their possible effects on the nation's intellectual property system. The three policy issues identified are:…

  18. Psychometric Properties of a Sleep Questionnaire for Use in Individuals with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Maas, Anneke P. H. M.; Didden, Robert; Korzilius, Hubert; Braam, Wiebe; Collin, Philippe; Smits, Marcel G.; Curfs, Leopold M. G.

    2011-01-01

    We examined the psychometric properties of one part of the Sleep Questionnaire developed by Simonds and Parraga (SQ-SP; 1982), a questionnaire that is frequently used to explore sleep problems and behaviors related to sleep in individuals with intellectual disability (ID). The SQ-SP was completed for 345 individuals with ID (sleep clinic n = 146;…

  19. Whose Idea Is This? Teaching Artists Reflect on Intellectual Property Issues

    ERIC Educational Resources Information Center

    Randall, Jill

    2006-01-01

    This article presents an interview with four seasoned Teaching Artists: Keith Terry, Kimberly de Caires, Ruth Bossieux, and Jeff Raz. The TAs reflect on the importance and complexity of intellectual property issues. They also shed new light on the views and experiences of TAs around this issue and encourages a broader dialog in the TA community.

  20. Intellectual Property Rights in E-Learning Programmes: Report of the Working Group.

    ERIC Educational Resources Information Center

    Higher Education Funding Council for England, Bristol.

    This report is a good practice guide for higher education institutions on intellectual property rights in e-learning programs. The report includes model clauses that may be included in contracts at higher education institutions and incorporates comments from a previous limited "expert" consultation. It focuses on how to manage…

  1. Intellectual Property and Copyright: Protecting Educational Interests and Managing Changing Environments.

    ERIC Educational Resources Information Center

    Bruwelheide, Janis H.

    The electronic environment is currently forcing educators at all levels to revisit issues concerning intellectual property. Quick availability of information and data through the Internet has changed the way the general public views information since it seems to be in endless supply from any computer on any individual desktop. This paper presents…

  2. An Overview of Intellectual Property Issues Associated with Distance Learning in Florida.

    ERIC Educational Resources Information Center

    Florida State Legislature, Tallahassee.

    This report serves as an overview of intellectual property law, policies, and practices as they relate to distance learning. It seeks to provide background information and direction for the Florida Distance Learning Network and the Postsecondary Education Planning Commission's Task Force on Telecommunications. Several of the technologies used in…

  3. 75 FR 68325 - Government Programs to Assist Businesses Protect Their Intellectual Property Rights (IPR) in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ...) concerning government programs for protecting the intellectual property rights of U.S. businesses in foreign... rights in foreign markets. The goal of the review is to improve efforts to support U.S. businesses facing... rights in foreign markets in particular. 2. Identify specific challenges businesses, including SMEs,...

  4. Can you shrinkwrap a cow? Protections available for the intellectual property of the animal breeding industry.

    PubMed

    Ogden, E R; Weigel, K

    2007-12-01

    There are currently four main intellectual property protection statutory schemes available: copyright, trade secret, trademark and patent. Each of these protects a different aspect of intellectual property, which leaves gaps of protection when an innovation does not fit squarely within the boundaries of the statutes. Contracts allow the industry to tailor the protection desired. One very common approach is to license the product via contract. Licences allow intellectual property owners to retain ownership and give permission to others to use the product. Although there are several types of licences, the most common is the field of use licence, which limits the licensee's use of the product. This often leads to price discrimination where various levels of restriction are offered at corresponding prices. The more rights retained by the owner, the more restricted the buyer is and the lower the purchase price allowing customers to choose the level of restriction they are willing to accept. Therefore, the different uses and needs of various customers can be accounted for and reflected in the price. The animal breeding industry is currently struggling to protect their innovations falling into these statutory gaps. The protection for animal breeding industry innovations is most likely through contract law rather than traditional intellectual property law. By taking advantage of the unique nature of contracts, industry will be able to tailor protection and pricing to best suit the variety of customers and uses for the products sold.

  5. Global Justice and Intellectual Property Rights: Reforming the International IPR Regime for Balanced Development

    ERIC Educational Resources Information Center

    Salokannel, Marjut

    2006-01-01

    Today it is widely recognized that a uniform global intellectual property (IP) system requiring a high level of protection is inherently unjust and affects countries differently depending upon their level of technological and economic development. This article analyzes the functioning of the current international treaty framework having…

  6. 31 CFR 542.520 - Certain transactions related to patents, trademarks, copyrights, and other intellectual property...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., trademark, copyright or other intellectual property protection in the United States or Syria are authorized, including exportation of services to Syria, payment for such services, and payment to persons in Syria... the United States Government or the Government of Syria, or of the reasonable and customary fees...

  7. The ethics of intellectual property rights in an era of globalization.

    PubMed

    Shah, Aakash Kaushik; Warsh, Jonathan; Kesselheim, Aaron S

    2013-01-01

    Since the 1980s, developed countries, led by the United States and the countries of the European Union, have sought to incorporate intellectual property rights provisions into global trade agreements. These countries successfully negotiated the World Trade Organization's 1994 Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), which required developing countries to adopt intellectual property provisions comparable to developed countries. In this manuscript, we review the policy controversy surrounding TRIPS and examine the two main ethical arguments articulated in its support--a theory of natural rights and a utilitarian argument. We contend that these theories provide insufficient bases for an intellectual property rights regime that compromises access to essential medicines in the developing world. While the policy community has engaged in active debate around the policy effects of TRIPS, scholars have not thoroughly considered the full ethical underpinnings of those policy arguments. We believe that a more robust understanding of the ethical implications of the agreement should inform policy discussions in the future.

  8. 32 CFR 37.550 - May I accept intellectual property as cost sharing?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false May I accept intellectual property as cost sharing? 37.550 Section 37.550 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business...

  9. 32 CFR 37.550 - May I accept intellectual property as cost sharing?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false May I accept intellectual property as cost sharing? 37.550 Section 37.550 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business...

  10. 3 CFR 13565 - Executive Order 13565 of February 8, 2011. Establishment of the Intellectual Property Enforcement...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and Organization for Intellectual Property Act of 2008 (Public Law 110-403)(15 U.S.C. 8111-8116) (the... Joint Strategic Plan required every 3 years under title III of the PRO IP Act (15 U.S.C. 8113... (15 U.S.C. 8111(b)(3)). (b) Membership. The Enforcement Advisory Committee shall be composed of...

  11. [On the interrelationship between standardization and intellectual property rights of acu-moxibustion therapy].

    PubMed

    Liu, Mai-lan; Chang, Xiao-rong; Yuan, Yi-qin

    2014-10-01

    Under the condition of knowledge economy, the acu-moxibustion standardization definitely involves intellectual property rights. Then, what is the relationship between the standardization and the intellectual property rights of acu-moxibustion? The authors of the present paper hold that it is not only exclusive, but also syncretic. If their relationship cannot be handled properly, their own respective development will be affected adversely. Therefore, a proper handling of the relationship between the two is of great practical significance. The present paper makes a comprehensive analysis about their interaction (mutual promotion and mutual inhibition), similarities (systemic composition, dynamic implementation course, standardization-rated order and ultimate targets) and differences (in properties, working components, secret requirement, effectiveness-time limitation, usage cost, etc).

  12. Effects of a Self-Monitoring Strategy on Independent Work Behavior of Students with Mild Intellectual Disability

    ERIC Educational Resources Information Center

    Coughlin, Jennifer; McCoy, Kathleen M.; Kenzer, Amy; Mathur, Sarup R.; Zucker, Stanley H.

    2012-01-01

    This study evaluated the effectiveness of a self-monitoring strategy on independent work behavior. The three subjects were in first grade, seven years old, identified with mild intellectual disability (MID), and had an Individualized Education Plan (IEP) with targeted functional academic and behavior goals. The purpose of this study was to…

  13. Importance and Satisfaction of Preventive Health Strategies in Institutions for People with Intellectual Disabilities: A Perspective of Institutional Directors

    ERIC Educational Resources Information Center

    Lin, J. D.; Yen, C. F.; Wu, J. L.

    2005-01-01

    Aim: To explore the perceptions of institutional directors on the preventive health strategies for people with intellectual disabilities in institutions. Methods: A structured questionnaire was conducted by a cross-sectional postal survey in all registered institutions in Taiwan in 2002. A total of 157 questionnaires were mailed, of which 121…

  14. Space Shuttle, private enterprise and intellectual properties in the context of space manufacturing

    NASA Technical Reports Server (NTRS)

    Hosenball, S. N.; Kempf, R. F.

    1983-01-01

    It is a national policy to make the capabilities of the Space Transportat ion System available to a wide range of potential users. This includes its availability as a space manufacturing facility for commercial activities, which may be carried out on a reimbursable basis or as a joint endeavor with NASA, but with substantial private investment. In any high risk, long lead-time research and development activity directed towards commercialization, the protection afforded the results of the research and development under the laws relating to intellectual property rights may provide an important incentive for private investment. The paper reviews NASA's policies and practices for the protection of privately-established intellectual property rights involved in STS use, with particular emphasis on reimbursable launch agreements and joint endeavor agreements.

  15. Promoting global health: utilizing WHO to integrate public health, innovation and intellectual property.

    PubMed

    Mackey, Tim K; Liang, Bryan A

    2012-12-01

    The appropriate role of innovation and intellectual property (IP) in global public health is a controversial issue. Discussion is one-sided, with potential benefits advocated by industry in stark contrast to condemnation by certain civil society players. WHO's Public Health, Innovation and Intellectual Property Department (PHI) was established to address healthcare resource need for developing countries, assess impact of innovation and IP on access to medicines, explore innovative funding mechanisms for R&D and provide evidence-based policy-making recommendations in response to the changing global health landscape. Importantly, PHI could represent a potential forum to bridge shared, yet often diverse, interests and opportunities between various public and private stakeholders, a crucial issue for ensuring the future viability of WHO.

  16. [Essential medicines and the TRIPS Agreement: collision between the right to health and intellectual property rights].

    PubMed

    Allard Soto, Raúl

    2015-03-01

    The strengthening of pharmaceutical patent protection globally puts strains on access to essential medicines. According to the present paper, this process has led to the collision of the intellectual property rights adopted in the World Trade Organization (WTO) Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement and the right to health stated in the International Covenant on Economic, Social and Cultural Rights (ICESCR). Several controversies disputed in the WTO illustrate the confrontation between countries with a powerful pharmaceutical industry and the interests of developing countries. It is concluded that the TRIPS-plus rules subscribed to by developing countries in free trade agreements which give the pharmaceutical patent holder more rights than those stipulated in the original TRIPS Agreement are incompatible with the obligations to provide access to essential medicines under the right to health of the ICESCR.

  17. Canada and access to medicines in developing countries: intellectual property rights first.

    PubMed

    Lexchin, Joel

    2013-09-03

    Canadian reports have recommended that health as a human right must be Canada's overarching global commitment and that the primacy of human rights should be prioritized over other elements of international law including international trade and investment law as it applies to access to pharmaceuticals. This paper uses a series of case reports to examine Canada's commitment to this goal. Specifically it examines cases where improved access has been in conflict with increased intellectual property rights. The 6 cases are: Canada's position when 39 pharmaceutical companies took South Africa to court in 1998 over its legislation to allow parallel importation of patented medicines and to regulate the price of medications; the stance that Canada took in the negotiations around the Doha Declaration in 2001; the passage of Canada's Access to Medicines Regime in 2004 and subsequent attempts to amend the legislation in 2011 and 2012; Canada's involvement in the final declaration at the United Nations High-Level meeting on non-communicable diseases in 2012; Canada's views about the terms in the Anti-Counterfeiting Trade Agreement as expressed in 2009; and Canada's 2013 position on the extension of the exemption for least developed countries from having to comply with the terms of the Trade Related Aspects of Intellectual Property Rights Agreement. In the first case Canada was neutral but in the remaining 5 cases Canada prioritized intellectual property rights over access. This position is consistent with how Canada has acted around domestic issues involving intellectual property rights for pharmaceutical products. Canada has supported strengthened rights despite the fact that their touted benefits have not been realized either domestically or in developing countries. As a result Canada has failed in its humanitarian duty to protect the human right to health in the form of safe and low cost medicines for the people in developing countries.

  18. Canada and access to medicines in developing countries: intellectual property rights first

    PubMed Central

    2013-01-01

    Canadian reports have recommended that health as a human right must be Canada’s overarching global commitment and that the primacy of human rights should be prioritized over other elements of international law including international trade and investment law as it applies to access to pharmaceuticals. This paper uses a series of case reports to examine Canada’s commitment to this goal. Specifically it examines cases where improved access has been in conflict with increased intellectual property rights. The 6 cases are: Canada’s position when 39 pharmaceutical companies took South Africa to court in 1998 over its legislation to allow parallel importation of patented medicines and to regulate the price of medications; the stance that Canada took in the negotiations around the Doha Declaration in 2001; the passage of Canada’s Access to Medicines Regime in 2004 and subsequent attempts to amend the legislation in 2011 and 2012; Canada’s involvement in the final declaration at the United Nations High-Level meeting on non-communicable diseases in 2012; Canada’s views about the terms in the Anti-Counterfeiting Trade Agreement as expressed in 2009; and Canada’s 2013 position on the extension of the exemption for least developed countries from having to comply with the terms of the Trade Related Aspects of Intellectual Property Rights Agreement. In the first case Canada was neutral but in the remaining 5 cases Canada prioritized intellectual property rights over access. This position is consistent with how Canada has acted around domestic issues involving intellectual property rights for pharmaceutical products. Canada has supported strengthened rights despite the fact that their touted benefits have not been realized either domestically or in developing countries. As a result Canada has failed in its humanitarian duty to protect the human right to health in the form of safe and low cost medicines for the people in developing countries. PMID:24007595

  19. The role of the University Licensing Office in transferring intellectual property to industry

    NASA Technical Reports Server (NTRS)

    Preston, John T.

    1992-01-01

    Universities in the US have a significant impact on business through the transfer of technology. This transfer of technology takes various forms, including faculty communications, faculty consulting activities, and the direct transfer of technology through the licensing of patents, copyrights, and other intellectual property to industry. The topics discussed include the following: background of the MIT Technology Licensing Office (TLO), goals of the MIT TLO, MIT's technology transfer philosophy, and important factors for success in new company formation.

  20. Intellectual property rights and research disclosure in the university environment: preserving the commercialization option and optimizing market interest.

    PubMed

    Patino, Robert

    2009-03-01

    Clinical and basic scientists at academic medical and biomedical research institutions often form ideas that could have both monetary and human health benefits if developed and applied to improvement of human wellbeing. However, such ideas lose much of their potential value in both regards if they are disclosed in traditional knowledge-sharing forums such as abstracts, posters, and oral presentations at research meetings. Learning the basics about intellectual property protection and obtaining professional guidance in the management of intellectual property from a knowledgeable technology management professional or intellectual property attorney can avoid such losses yet pose a minimal burden of confidentiality on the investigator. Knowing how to successfully navigate the early stages of intellectual property protection can greatly increase the likelihood that discoveries and knowledge will become available for the public good without diminishing the important mandate of disseminating knowledge through traditional knowledge-sharing forums.

  1. Intellectual Property Rights and Research Disclosure in the University Environment: Preserving the Commercialization Option and Optimizing Market Interest

    PubMed Central

    2009-01-01

    Clinical and basic scientists at academic medical and biomedical research institutions often form ideas that could have both monetary and human health benefits if developed and applied to improvement of human wellbeing. However, such ideas lose much of their potential value in both regards if they are disclosed in traditional knowledge-sharing forums such as abstracts, posters, and oral presentations at research meetings. Learning the basics about intellectual property protection and obtaining professional guidance in the management of intellectual property from a knowledgeable technology management professional or intellectual property attorney can avoid such losses yet pose a minimal burden of confidentiality on the investigator. Knowing how to successfully navigate the early stages of intellectual property protection can greatly increase the likelihood that discoveries and knowledge will become available for the public good without diminishing the important mandate of disseminating knowledge through traditional knowledge-sharing forums. PMID:19383208

  2. 10 CFR 603.550 - Acceptability of intellectual property.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... property (e.g., copyrighted material, including software) as cost sharing because: (1) It is difficult to... the contribution. For example, a for-profit firm may offer the use of commercially available software for which there is an established license fee for use of the product. The costs of the development...

  3. 10 CFR 603.550 - Acceptability of intellectual property.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... property (e.g., copyrighted material, including software) as cost sharing because: (1) It is difficult to... the contribution. For example, a for-profit firm may offer the use of commercially available software... the software would not be a reasonable basis for valuing its use....

  4. Trusted Module Acquisition Through Proof-Carrying Hardware Intellectual Property

    DTIC Science & Technology

    2015-05-22

    microprocessor IPs or cryptographic cores, and automate parts or all of the extra duties imposed by the PCHIP on hardware IP developers. PCHIP...fundamental PCHIP framework, enhance its capabilities to be usable for various hardware types with different requirements, e.g. microprocessor IPs or...of formal proofs for those security theorems. We established a set of security properties which ensure the trustworthiness of microprocessor IPs and

  5. Beyond the Ingelfinger Rule: the intellectual property ethics after the end of biomedical journals' monopoly.

    PubMed

    Germenis, A E

    1999-01-01

    According to the so-called Ingelfinger Rule (IR), biomedical journals do not accept for publication papers which have already been publicized elsewhere. This rule was subjected to fierce criticism which was mainly based on the fact that authors transfer the intellectual rights of their work to the journals. With the emergence of the Internet, the scientific community has a golden opportunity to re-evaluate the IR concept. Scientists no longer have to depend on the debatable benefits (i.e. publicity and review) stemming from journal publications; rather they can be free to explore novel communication opportunities and, subsequently, to tackle the emerging intellectual property issues. This approach should take into account the tight bond between applied research and the world economy, the need for teamwork instead of individual effort for effective scientific research, and the added value of journal publications. Based on such an analysis, it would appear that the inherent characteristics of the Internet promote a re-assessment of the intellectual property theory on three levels: the cognitive (the way in which knowledge is made up from its building blocks), the morphological (the use of hypertext) and finally the sociological (the formation of virtual scientific communities). It is concluded that publishing on the Internet necessitates a different approach to the question of intellectual property based on the primal values of science. This can be achieved only if the scientific community embraces and nourishes the academic nature of the Internet as well as laying down the rules to control the dissemination of ideas without the intervention of non-scientific third parties.

  6. A typology of intellectual property management for public health innovation and access: design considerations for policymakers.

    PubMed

    Taubman, Antony

    2010-01-19

    This paper seeks to set the practical discipline of public interest intellectual property (IP) management in public health into its broader policy context. The most immediate and direct impact of IP systems on public welfare results not from international standards nor from national legislation - though these norms are fundamentally important - but rather from the accumulated impact of numerous practical choices whether or not to seek IP protection; where and where not; and how any exclusive rights are deployed, by whom, and to what end. IP management is the essentially practical exercise of limited exclusive rights over protected subject matter, the judicious use of those rights to leverage outcomes that advance an institution's or a firm's objectives. Exclusive rights are used to construct and define knowledge-based relationships, to leverage access to technology and other necessary resources, and to enhance market-based incentives. IP management choices range across a broad spectrum, spanning public domain strategies, open or exclusive licensing, and strong exclusivity. The idea of 'exclusive rights', as a specific legal mechanism, can run counter to expectations of greater openness and accessibility, but actual outcomes will depend very much on how these mechanisms are used in practice. For public interest or public sector institutions concerned with health research and development, particularly the development of new medicines, IP management choices can be just as critical as they are for private firms, although a predominant institutional concentration on advancing direct public interest objectives may lead to significantly different approaches in weighing and exercising practical choices for IP management: even so, a private sector approach should not be conflated with exclusivity as an end in itself, nor need public interest IP management eschew all leverage over IP. This paper offers a tentative framework for a richer typology of those choices, to give a

  7. Transposon tools: worldwide landscape of intellectual property and technological developments.

    PubMed

    Palazzoli, Fabien; Testu, François-Xavier; Merly, Franck; Bigot, Yves

    2010-03-01

    DNA transposons are considered to be good candidates for developing tools for genome engineering, insertional mutagenesis and gene delivery for therapeutic purposes, as illustrated by the recent first clinical trial of a transposon. In this article we set out to highlight the interest of patent information, and to develop a strategy for the technological development of transposon tools, similar to what has been done in many other fields. We propose a patent landscape for transposon tools, including the changes in international patent applications, and review the leading inventors and applicants. We also provide an overview of the potential patent portfolio for the prokaryotic and eukaryotic transposons that are exploited by spin-off companies. Finally, we discuss the difficulties involved in tracing relevant state-of-the-art of articles and patent documents, based on the example of one of the most promising transposon systems, including all the impacts on the technological development of transposon tools.

  8. Protecting intellectual property associated with Canadian academic clinical trials--approaches and impact.

    PubMed

    Ross, Sue; Magee, Laura; Walker, Mark; Wood, Stephen

    2012-12-27

    Intellectual property is associated with the creative work needed to design clinical trials. Two approaches have developed to protect the intellectual property associated with multicentre trial protocols prior to site initiation. The 'open access' approach involves publishing the protocol, permitting easy access to the complete protocol. The main advantages of the open access approach are that the protocol is freely available to all stakeholders, permitting them to discuss the protocol widely with colleagues, assess the quality and rigour of the protocol, determine the feasibility of conducting the trial at their centre, and after trial completion, to evaluate the reported findings based on a full understanding of the protocol. The main potential disadvantage of this approach is the potential for plagiarism; however if that occurred, it should be easy to identify because of the open access to the original trial protocol, as well as ensure that appropriate sanctions are used to deal with plagiarism. The 'restricted access' approach involves the use of non-disclosure agreements, legal documents that must be signed between the trial lead centre and collaborative sites. Potential sites must guarantee they will not disclose any details of the study before they are permitted to access the protocol. The main advantages of the restricted access approach are for the lead institution and nominated principal investigator, who protect their intellectual property associated with the trial. The main disadvantages are that ownership of the protocol and intellectual property is assigned to the lead institution; defining who 'needs to know' about the study protocol is difficult; and the use of non-disclosure agreements involves review by lawyers and institutional representatives at each site before access is permitted to the protocol, significantly delaying study implementation and adding substantial indirect costs to research institutes. This extra step may discourage sites from

  9. Health Promotion and Disease Prevention Strategies in Older Adults with Intellectual and Developmental Disabilities

    PubMed Central

    Carmeli, Eli; Imam, Bita

    2014-01-01

    The rapid growth in the number of individuals living with intellectual and developmental disabilities (IDD) along with their increased longevity present challenges to those concerned about health and well-being of this unique population. While much is known about health promotion and disease prevention in the general geriatric population, far less is known about those in older adults with IDD. Effective and efficient health promotion and disease prevention strategies need to be developed and implemented for improving the health and quality of life of older adults living with IDD. This is considered to be challenging given the continued shrinkage in the overall health care and welfare system services due to the cut in the governmental budget in some of the western countries. The ideal health promotion and disease prevention strategies for older adults with IDD should be tailored to the individuals’ health risks, address primary and secondary disease prevention, and prevent avoidable impairments that cause premature institutionalization. Domains of intervention should include cognitive, mental and physical health, accommodations, workplace considerations, assistive technology, recreational activities, and nutrition. PMID:24783190

  10. The Effectiveness of the Instructional Programs Based on Self-Management Strategies in Acquisition of Social Skills by the Children with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Avcioglu, Hasan

    2012-01-01

    The purpose of this study is to evaluate the effectiveness of self-management skills training program, based on self-control strategies, on students with intellectual disabilities. A multiple-probe design across subjects single-subject research methodology was used in this study. Nine students with intellectual disabilities, whose ages are between…

  11. Making Work Fit Care: Reconciliation Strategies Used by Working Mothers of Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Chou, Yueh-Ching; Fu, Li-yeh; Chang, Heng-Hao

    2013-01-01

    Background: This study explored the experiences of working mothers with an adult child with intellectual disabilities to understand how they reconcile paid work and care responsibilities. Methods: Fifteen working mothers in Taiwan with an adult child with intellectual disabilities were interviewed, and an interpretative phenomenological approach…

  12. Analysis of intellectual properties on animal-derived regenerative, implantable medical devices

    PubMed Central

    Wang, Hongman; Li, Chunying

    2016-01-01

    This article analyses and summarizes issues of intellectual property involved in animal-derived regenerative, implantable medical devices (ADRIMD) in order to better understand global trends in patent applications and disclosures, the legal status of patent families (i.e. sets of patents filed in various countries to protect a single invention), and International Patent Classification topics such as main assignee and core expertise. Analysis of research trends will enhance and inform the decision-making capacity of researchers, investors, government regulators and other stake-holders as they undertake to develop, deploy, invest in or regulate ADRIMD. PMID:26816653

  13. On the importance of intellectual property rights for e-science and the integrated health record.

    PubMed

    D'Agostino, Giuseppina; Hinds, Chris; Jirotka, Marina; Meyer, Charles; Piper, Tina; Rahman, Mustafizur; Vaver, David

    2008-06-01

    An integrated health record (IHR) that enables clinical data to be shared at a national level has profound implications for medical research. Data that have been useful primarily within a single clinic will instead be free to move rapidly around a national network infrastructure. This raises challenges for technologists, clinical practice, and for the governance of these data. This article considers one specific issue that is currently poorly understood: how intellectual property (IP) relates to the sharing of medical data for research on large-scale electronic networks. Based on an understanding of current practices, this article presents recommendations for the governance of IP in an integrated health record.

  14. Managing severe acute respiratory syndrome (SARS) intellectual property rights: the possible role of patent pooling.

    PubMed Central

    Simon, James H. M.; Claassen, Eric; Correa, Carmen E.; Osterhaus, Albert D. M. E.

    2005-01-01

    Patent applications that incorporate the genomic sequence of the severe acute respiratory syndrome (SARS) coronavirus, have been filed by a number of organizations. This is likely to result in a fragmentation of intellectual property (IP) rights which in turn may adversely affect the development of products, such as vaccines, to combat SARS. Placing these patent rights into a patent pool to be licensed on a non-exclusive basis may circumvent these difficulties and set a key precedent for the use of this form of mechanism in other areas of health care, leading to benefits to public health. PMID:16211163

  15. Thought police. Healthcare executives must carefully guard intellectual property developed in their facilities.

    PubMed

    Scott, J S

    1991-03-01

    Healthcare executives should have a working knowledge of intellectual property law--the legal principle that, for a limited period, treats intangible ideas and concepts as if they were products or property. Not only should administrators be aware of how to protect their facilities' patents, trademarks, copyrights, and trade secrets, but they must also be sure that employees in their own facilities do not infringe on the intellectual property of others. A patent is granted when an inventor proposes a useful new process, machine, "article of manufacture," or composition of matter, including any new and useful improvement on existing items in these same categories. A trademark is a name, symbol, device, or combination thereof adopted and used by an institution to identify its goods or services and to distinguish them from its competitors' goods or services. Expressions of ideas and thoughts set forth in words, sentences, paragraphs, sketches, pictures, graphs, or any other means of conveying ideas or concepts commonly understood to be works of authorship--both published and unpublished--may be protected by a copyright. Trade secret law applies to those who might misappropriate information that has been given to them because of their special relationship with the holder of the trade secret (i.e., through employment, contract, or other fiduciary or trust relationship).

  16. An intellectual property sharing initiative in agricultural biotechnology: development of broadly accessible technologies for plant transformation.

    PubMed

    Chi-Ham, Cecilia L; Boettiger, Sara; Figueroa-Balderas, Rosa; Bird, Sara; Geoola, Josef N; Zamora, Pablo; Alandete-Saez, Monica; Bennett, Alan B

    2012-06-01

    The Public Intellectual Property Resource for Agriculture (PIPRA) was founded in 2004 by the Rockefeller Foundation in response to concerns that public investments in agricultural biotechnology benefiting developing countries were facing delays, high transaction costs and lack of access to important technologies due to intellectual property right (IPR) issues. From its inception, PIPRA has worked broadly to support a wide range of research in the public sector, in specialty and minor acreage crops as well as crops important to food security in developing countries. In this paper, we review PIPRA's work, discussing the failures, successes, and lessons learned during its years of operation. To address public sector's limited freedom-to-operate, or legal access to third-party rights, in the area of plant transformation, we describe PIPRA's patent 'pool' approach to develop open-access technologies for plant transformation which consolidate patent and tangible property rights in marker-free vector systems. The plant transformation system has been licensed and deployed for both commercial and humanitarian applications in the United States (US) and Africa, respectively.

  17. Whose body is it anyway? Human cells and the strange effects of property and intellectual property law.

    PubMed

    Feldman, Robin

    2011-06-01

    Whatever else I might own in this world, it would seem intuitively obvious that I own the cells of my body. Where else could the notion of ownership begin, other than with the components of the tangible corpus that all would recognize as "me"? The law, however, does not view the issue so neatly and clearly, particularly when cells are no longer in my body. As so often happens in law, we have reached this point, not by design, but by the piecemeal development of disparate notions that, when gathered together, form a strange and disconcerting picture. This Article examines both property and intellectual property doctrines in relation to human cells that are no longer within the body. In particular, the Article discusses the Bilski decision, in the context of life science process patents, and the Molecular Pathology case, in the context of gene patents. For patent law, the Article concludes that the problem lies not with the fact that genes constitute patentable subject matter, but rather with the extent of the rights that are granted. For both property and intellectual property law, the Article concludes that a more careful application of basic legal principles would better reflect the interests of society as a whole and the interests of individual human subjects, as well as the interests of those who innovate.

  18. The Effects of Intellectual Property Rights on Access to Medicines and Catastrophic Expenditure.

    PubMed

    Jung, Youn; Kwon, Soonman

    2015-01-01

    Since the introduction of Trade-Related Aspects of Intellectual Property Rights (TRIPS) in 1995, there has been considerable concern that poor access to essential medicines in developing countries would be exacerbated because strengthening intellectual property rights (IPR) leads to monopoly of pharmaceutical markets and delayed entry of lower-cost generic drugs. However, despite extensive research and disputes regarding this issue, there are few empirical studies on the topic. In this study, we investigated the effect of IPR on access to medicines and catastrophic expenditure for medicines, using data from World Health Surveys 2002-2003. The index of patent rights developed by Ginarte and Park (1997) was used to measure the IPR protection level of each country. Estimates were adjusted for individual and country characteristics. In the results of multilevel logistic regression analyses, higher level of IPR significantly increased the likelihood of nonaccess to prescribed medicines even after controlling for individual socioeconomic status and national characteristics associated with access to medicines. This study's finding on the negative impact of IPR on access to medicines calls for the implementation of more active policy at the supra-national level to improve access in low- and middle-income countries.

  19. The Regional Comprehensive Economic Partnership, Intellectual Property Protection, and Access to Medicines.

    PubMed

    Townsend, Belinda; Gleeson, Deborah; Lopert, Ruth

    2016-11-01

    The inclusion of elevated standards of intellectual property (IP) protection in the recently negotiated Trans-Pacific Partnership (TPP) agreement has raised serious public health concerns regarding access to medicines. A lesser-known trade agreement under negotiation in the Asia-Pacific region is the Regional Comprehensive Economic Partnership (RCEP). Framed as an attempt to reassert ASEAN's position in response to the United States-led TPP, RCEP includes key players China and India as well as several low- and middle-income countries (LMICs). Leaked drafts of IP provisions proposed by Japan and South Korea raise similar concerns in the Asia-Pacific region. This article identifies TRIPS (Trade Related Aspects of Intellectual Property Rights agreement)-Plus provisions in leaked negotiating texts and examines their implications for LMICs that are not also parties to the TPP: Cambodia, Indonesia, Laos, Myanmar, the Philippines, Thailand, China, and India. We find that higher levels of IP protection delay the market entry of generic medicines, giving rise to increased costs to governments and reduced access to essential medicines. The article concludes that the public health community should recognize risks inherent in trade agreements that promote expansions of IP rights and engage with governments to ensure that public health is adequately and explicitly protected in trade and investment negotiations.

  20. Changes to intellectual property policy in South Africa: putting a stop to evergreening?

    PubMed

    Hill, Julia E

    2014-08-01

    South Africa is a middle-income country with the world's largest HIV patient cohort and a growing burden of communicable and non-communicable diseases - a prime location for pharmaceutical companies looking to expand their markets. Yet, 20 years after the country's first democratic elections, poor health indicators and an over-burdened public health system belie persistently stark levels of socioeconomic inequality. As the South African government revises national intellectual property (IP) policies, the pharmaceutical industry and global access to medicines movement are watching, aware of ramifications South Africa's actions will have on patent laws and the availability of generic medicines in other middle-income countries and across Africa. South Africa's draft IP policy is meeting fierce resistance from industry, although proposed reforms are compliant with the Agreement on trade related aspects of intellectual property (TRIPS) and in line with on-going policies and actions of both developing and developed countries. Could the establishment of a patent examination system and new patentability criteria rein in evergreening and lead to lower medicine prices? What will be the potential impact of reform on medical innovation? And why is it both necessary and urgent that the South African government seek a fairer balance between private and public interests?

  1. Intellectual property rights, moral imagination, and access to life-enhancing drugs.

    PubMed

    Werhane, Patricia H; Gorman, Michael

    2005-10-01

    Although the idea of intellectual property (IP) rights--proprietary rights to what one invents, writes, paints, composes or creates--is firmly embedded in Western thinking, these rights are now being challenged across the globe in a number of areas. This paper will focus on one of those challenges: government-sanctioned copying of patented drugs without permission or license of the patent owner in the name of national security, in health emergencies, or life-threatening epidemics. After discussing standard rights-based and utilitarian arguments defending intellectual property we will present another model. IP is almost always a result of a long history of of scientific or technological development and numbers of networks of creativity, not the act of a single person or a group of people at one moment in time. Thus thinking about and evaluating IP requires a traditional model of IP. It follows that the owner of those rights has some obligations to share that information or its outcomes. If that conclusion is applied to the distribution of antiretroviral drugs, what pharmaceutical companies are ethically required to do to increase access to these medicines in the developing world will have to be reanalyzed from a more systemic perspective.

  2. Data sharing and intellectual property in a genomic epidemiology network: policies for large-scale research collaboration.

    PubMed Central

    Chokshi, Dave A.; Parker, Michael; Kwiatkowski, Dominic P.

    2006-01-01

    Genomic epidemiology is a field of research that seeks to improve the prevention and management of common diseases through an understanding of their molecular origins. It involves studying thousands of individuals, often from different populations, with exacting techniques. The scale and complexity of such research has required the formation of research consortia. Members of these consortia need to agree on policies for managing shared resources and handling genetic data. Here we consider data-sharing and intellectual property policies for an international research consortium working on the genomic epidemiology of malaria. We outline specific guidelines governing how samples and data are transferred among its members; how results are released into the public domain; when to seek protection for intellectual property; and how intellectual property should be managed. We outline some pragmatic solutions founded on the basic principles of promoting innovation and access. PMID:16710548

  3. Patenting nature or protecting culture? Ethnopharmacology and indigenous intellectual property rights

    PubMed Central

    McGonigle, Ian Vincent

    2016-01-01

    Ethnopharmacologists are scientists and anthropologists that study indigenous medicines and healing practices, and who often develop new therapies and medicines for wider use. Ethnopharmacologists do fieldwork with indigenous peoples in traditional societies, where they encounter a wide range of cultural values and varying ideas about the nature of property relations. This poses difficulties for protecting indigenous intellectual property and for making just trade agreements. This Note reviews the legal issues relevant to the protection of indigenous resources in ethnopharmacology trade agreements, and suggests that recent developments in anthropology and the social study of science could be instructive in furthering the legal discourse and in providing policy directions. Specifically, the Note introduces the concepts of ‘ontological pluralism’ and ‘epistemic subsidiarity’, which could help lawmakers write sui generis trade agreements to better protect indigenous knowledge and resources. PMID:27774245

  4. Patenting nature or protecting culture? Ethnopharmacology and indigenous intellectual property rights.

    PubMed

    McGonigle, Ian Vincent

    2016-04-01

    Ethnopharmacologists are scientists and anthropologists that study indigenous medicines and healing practices, and who often develop new therapies and medicines for wider use. Ethnopharmacologists do fieldwork with indigenous peoples in traditional societies, where they encounter a wide range of cultural values and varying ideas about the nature of property relations. This poses difficulties for protecting indigenous intellectual property and for making just trade agreements. This Note reviews the legal issues relevant to the protection of indigenous resources in ethnopharmacology trade agreements, and suggests that recent developments in anthropology and the social study of science could be instructive in furthering the legal discourse and in providing policy directions. Specifically, the Note introduces the concepts of 'ontological pluralism' and 'epistemic subsidiarity', which could help lawmakers write sui generis trade agreements to better protect indigenous knowledge and resources.

  5. The effects of business practices, licensing, and intellectual property on development and dissemination of the polymerase chain reaction: case study

    PubMed Central

    Fore, Joe; Wiechers, Ilse R; Cook-Deegan, Robert

    2006-01-01

    Introduction Polymerase chain reaction (PCR) was a seminal genomic technology discovered, developed, and patented in an industry setting. Since the first of its core patents expired in March, 2005, we are in a position to view the entire lifespan of the patent, examining how the intellectual property rights have impacted its use in the biomedical community. Given its essential role in the world of molecular biology and its commercial success, the technology can serve as a case study for evaluating the effects of patenting biological research tools on biomedical research. Case description Following its discovery, the technique was subjected to two years of in-house development, during which issues of inventorship and publishing/patenting strategies caused friction between members of the development team. Some have feared that this delay impeded subsequent research and may have been due to trade secrecy or the desire for obtaining lucrative intellectual property rights. However, our analysis of the history indicates that the main reasons for the delay were benign and were primarily due to difficulties in perfecting the PCR technique. Following this initial development period, the technology was made widely available, but was subject to strict licensing terms and patent protection, leading to an extensive litigation history. Discussion and evaluation PCR has earned approximately $2 billion in royalties for the various rights-holders while also becoming an essential research tool. However, using citation trend analysis, we are able to see that PCR's patented status did not preclude it from being adopted in a similar manner as other non-patented genomic research tools (specifically, pBR322 cloning vector and Maxam-Gilbert sequencing). Conclusion Despite the heavy patent protection and rigid licensing schemes, PCR seems to have disseminated so widely because of the practices of the corporate entities which have controlled these patents, namely through the use of business

  6. Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing

    PubMed Central

    Redin, Claire; Gérard, Bénédicte; Lauer, Julia; Herenger, Yvan; Muller, Jean; Quartier, Angélique; Masurel-Paulet, Alice; Willems, Marjolaine; Lesca, Gaétan; El-Chehadeh, Salima; Le Gras, Stéphanie; Vicaire, Serge; Philipps, Muriel; Dumas, Michaël; Geoffroy, Véronique; Feger, Claire; Haumesser, Nicolas; Alembik, Yves; Barth, Magalie; Bonneau, Dominique; Colin, Estelle; Dollfus, Hélène; Doray, Bérénice; Delrue, Marie-Ange; Drouin-Garraud, Valérie; Flori, Elisabeth; Fradin, Mélanie; Francannet, Christine; Goldenberg, Alice; Lumbroso, Serge; Mathieu-Dramard, Michèle; Martin-Coignard, Dominique; Lacombe, Didier; Morin, Gilles; Polge, Anne; Sukno, Sylvie; Thauvin-Robinet, Christel; Thevenon, Julien; Doco-Fenzy, Martine; Genevieve, David; Sarda, Pierre; Edery, Patrick; Isidor, Bertrand; Jost, Bernard; Olivier-Faivre, Laurence; Mandel, Jean-Louis; Piton, Amélie

    2014-01-01

    Background Intellectual disability (ID) is characterised by an extreme genetic heterogeneity. Several hundred genes have been associated to monogenic forms of ID, considerably complicating molecular diagnostics. Trio-exome sequencing was recently proposed as a diagnostic approach, yet remains costly for a general implementation. Methods We report the alternative strategy of targeted high-throughput sequencing of 217 genes in which mutations had been reported in patients with ID or autism as the major clinical concern. We analysed 106 patients with ID of unknown aetiology following array-CGH analysis and other genetic investigations. Ninety per cent of these patients were males, and 75% sporadic cases. Results We identified 26 causative mutations: 16 in X-linked genes (ATRX, CUL4B, DMD, FMR1, HCFC1, IL1RAPL1, IQSEC2, KDM5C, MAOA, MECP2, SLC9A6, SLC16A2, PHF8) and 10 de novo in autosomal-dominant genes (DYRK1A, GRIN1, MED13L, TCF4, RAI1, SHANK3, SLC2A1, SYNGAP1). We also detected four possibly causative mutations (eg, in NLGN3) requiring further investigations. We present detailed reasoning for assigning causality for each mutation, and associated patients’ clinical information. Some genes were hit more than once in our cohort, suggesting they correspond to more frequent ID-associated conditions (KDM5C, MECP2, DYRK1A, TCF4). We highlight some unexpected genotype to phenotype correlations, with causative mutations being identified in genes associated to defined syndromes in patients deviating from the classic phenotype (DMD, TCF4, MECP2). We also bring additional supportive (HCFC1, MED13L) or unsupportive (SHROOM4, SRPX2) evidences for the implication of previous candidate genes or mutations in cognitive disorders. Conclusions With a diagnostic yield of 25% targeted sequencing appears relevant as a first intention test for the diagnosis of ID, but importantly will also contribute to a better understanding regarding the specific contribution of the many genes

  7. Strategies for Engagement: Knowledge Building and Intellectual Engagement in Participatory Learning Environments

    ERIC Educational Resources Information Center

    Jacobsen, Michele; Lock, Jennifer; Friesen, Sharon

    2013-01-01

    Intellectual engagement is an absorbing, creatively energized focus resulting in a deep personal commitment to exploration, investigation, problem-solving and inquiry over a sustained period of time. In this article, the authors argue that participatory learning environments with a focus on knowledge building offer clear learning benefits to…

  8. Characteristic Interviews, Different Strategies: Methodological Challenges in Qualitative Interviewing among Respondents with Mild Intellectual Disabilities

    ERIC Educational Resources Information Center

    Sigstad, Hanne Marie Høybråten

    2014-01-01

    Conducting qualitative research interviews among individuals with intellectual disabilities, including cognitive limitations and difficulties in communication, presents particular research challenges. One question is whether the difficulties that informants encounter affect interviews to such an extent that the validity of the results is weakened.…

  9. Research-Based Strategies for Teaching Content to Students with Intellectual Disabilities: Adapted Videos

    ERIC Educational Resources Information Center

    Evmenova, Anna S.; Behrmann, Michael M.

    2011-01-01

    Teachers are always seeking any visual and/or auditory supports to facilitate students' comprehension and acquisition of difficult concepts associated with academic content. Such supports are even more important for students with intellectual disabilities who regardless of their abilities and needs are required to have access and active…

  10. Intellectual property rights in synthetic biology: an anti-thesis to open access to research?

    PubMed

    Saukshmya, Trichi; Chugh, Archana

    2010-12-01

    Synthetic Biology is a surging area of contemporary life science based research that is rapidly evolving by virtue of its multidisciplinary composition and applications. Biology never before has seen such a gold rush and demonstrated potential for knowledge based economy. The area of synthetic biology is in a nascent and tender stage, however issues pertaining to open access to research versus the monopolistic intellectual property regime (specifically patents) have already started raising concerns in the emerging bio-based economy. The present study critically analyses the comparative benefits as well as lacunas of open access to research and patenting issues. It is noteworthy that both approaches for synthetic biology development have to co-exist in order to optimally benefit the society at large.

  11. A Marxist Analysis of the World Trade Organisation's Agreement on Trade-Related Aspects of Intellectual Property Rights

    ERIC Educational Resources Information Center

    Rikowski, Ruth

    2006-01-01

    This article examines the World Trade Organisation's (WTO) Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). There are many WTO Agreements, but TRIPS is likely to have significant implications for areas such as information, education and libraries. The article provides an overview of TRIPS in general. Various intellectual…

  12. Special Issue: Intellectual Property in the Information Age: Knowledge as Commodity and its Legal Implications for Higher Education

    ERIC Educational Resources Information Center

    Sun, Jeffrey C., Ed.; Baez, Benjamin, Ed.

    2009-01-01

    This monograph examines in great detail two kinds of intellectual property: copyrights and patents. Though the authors recognize the significance of trademarks and trade secrets, they focus primarily on copyrights and patents in this monograph because they represent the most significant issues in higher education in the information age.…

  13. Intellectual Property Rights of Faculty in the Digital Age--Evolution or Dissolution in 21st Century Academia?

    ERIC Educational Resources Information Center

    Aaron, Lynn S.; Roche, Catherine M.

    2015-01-01

    Unforeseen forces are at work in higher education today. The purpose of this article is to explore the issues involved in the changing landscape. Decisions are and will be made that impact the intellectual property rights of faculty. It is important to be cognizant of the factors involved and alert to possible ramifications. The basics of the…

  14. Intellectual Property Development and Use for Distance Education Courses: A Review of Law, Organizations, and Resources for Faculty

    ERIC Educational Resources Information Center

    Nemire, Ruth E.

    2007-01-01

    Advancement of knowledge and progress in technology drives the need for protecting inventions, new ideas, writings, music, and other media. While abundant, intellectual property and copyright issues are not simple, and the United States has adopted multiple rules via treaties worldwide. Academia has been fortunate with regard to the freedom…

  15. Antiepileptic Drugs with Mood Stabilizing Properties and Their Relation with Psychotropic Drug Use in Institutionalized Epilepsy Patients with Intellectual Disability

    ERIC Educational Resources Information Center

    Leunissen, C. L. F.; de la Parra, N. M.; Tan, I. Y.; Rentmeester, Th. W.; Vader, C. I.; Veendrick-Meekes, M. J. B. M.; Aldenkamp, A. P.

    2011-01-01

    A large number of patients with epilepsy and intellectual disability take medication, amongst which antiepileptic and psychotropic drugs, often simultaneously. Certain antiepileptic drugs have mood-stabilizing properties, e.g. carbamazepine, valproic acid and lamotrigine. The aim of this study was to investigate whether the use of these…

  16. Legal Issues of Intellectual Property Rights and Licensing for E-Learning Content in the United Kingdom

    ERIC Educational Resources Information Center

    Mehrpouyan, Azadeh; Razavi, Ghassem Khadem

    2014-01-01

    This article focuses on the legal rules of intellectual property rights (IPR) in networked e-learning. Its purpose is to act as an awareness-raising device about IPR, especially in the public-sector e-learning community in the UK, by describing the relevant aspects of IPR, providing legal guidance on IPR in e-learning, especially on the use of…

  17. The Psychometric Properties of the Hospital Anxiety and Depressions Scale Adapted for Use with People with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Dagnan, D.; Jahoda, A.; McDowell, K.; Masson, J.; Banks, P.; Hare, D.

    2008-01-01

    Background: There is increasing recognition of depression in people with intellectual disabilities (ID). There is a need to develop well-standardised self-report measures for both clinical and research purposes. This paper presents some psychometric properties of the Hospital Anxiety and Depression Scale (HADS) adapted for use with people with ID.…

  18. Improving the Oral Health of Residents with Intellectual and Developmental Disabilities: An Oral Health Strategy and Pilot Study

    PubMed Central

    Binkley, Catherine J.; Johnson, Knowlton W.; Abadi, Melissa; Thompson, Kirsten; Shamblen, Stephen R.; Young, Linda; Zaksek, Brigit

    2014-01-01

    This article presents an oral health (OH) strategy and pilot study focusing on individuals with intellectual and/or developmental disabilities (IDD) living in group homes. The strategy consists of four components: (1) planned action in the form of the behavioral contract and caregiver OH action planning; (2) capacity building through didactic and observation learning training; (3) environmental adaptations consisting of additional oral heath devices and strategies to create a calm atmosphere; and (4) reinforcement by post-training coaching. A pilot study was conducted consisting of pre- and post-assessment data collected one week before and one week after implementing a one-month OH strategy. The study sample comprised 11 group homes with 21 caregivers and 25 residents with IDD from one service organization in a Midwestern city. A process evaluation found high-quality implementation of the OH strategy as measured by dosage, fidelity, and caregiver reactions to implementing the strategy. Using repeated cross-sectional and repeated measures analyses, we found statistically significant positive changes in OH status and oral hygiene practices of residents. Caregiver self-efficacy as a mechanism of change was not adequately evaluated; however, positive change was found in some but not all types of caregiver OH support that were assessed. Lessons learned from implementing the pilot study intervention and evaluation are discussed, as are the next steps in conducting an efficacy study of the OH strategy. PMID:25137553

  19. Integrating Remote Sensing Data with Socioeconomic Data: Sensitivity, Confidentiality, Privacy, and Intellectual Property Challenges

    NASA Astrophysics Data System (ADS)

    Downs, R. R.; Adamo, S. B.

    2014-12-01

    The integration of remote sensing data with socioeconomic data presents new opportunities for scientific discovery and analysis that can improve understanding of the environmental sustainability issues that society faces today. Such integrated data products and services can be used to study interdisciplinary issues by investigators representing various disciplines. In addition to the scientific benefits that can be attained by integrating remote sensing data with socioeconomic data, the integration of these data also present challenges that reflect the complex issues that arise when sharing and integrating different types of science data. When integrating one or more datasets that contain sensitive information, data producers need to be aware of the limitations that have been placed upon the data to protect private property, species or other inhabitants that reside on the property, or restricted information about a particular location. Similarly, confidentiality and privacy issues are a concern for data that have been collected about individual humans and families who have volunteered to serve as human research subjects or whose personal information may have been collected without their knowledge. In addition, intellectual property rights that are associated with a particular dataset may prevent integration with other data or pose constraints on the use of the resulting data products or services. These challenges will be described along with approaches that can be applied to address them when planning projects that involve the integration of remote sensing data with socioeconomic data.

  20. INTELLECTUAL PROPERTY IN THE TWENTY-FIRST CENTURY: WILL THE DEVELOPING COUNTRIES LEAD OR FOLLOW?

    PubMed Central

    Reichman, Jerome H.

    2010-01-01

    Developing countries, particularly the BRIC countries of Brazil, Russia, India, and China, should accommodate their national systems of innovation to the worldwide intellectual property (IP) regime emerging after the adoption of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) in a way that maximizes global economic welfare in the foreseeable future. As many developed countries’ experience demonstrates, badly configured, over-protectionist IP regimes stifle innovation by making inputs to future innovation too costly and too cumbersome to sustain over time. More carefully considered IP regimes, however, are an important way to protect innovative small- and medium-sized firms from predatory, larger competitors. The challenge is for emerging economies to capture the benefits of IP without importing the serious problems that developed countries have themselves failed to solve. Emerging economies can attain this balance by pursuing a policy of counter-harmonization in which they take advantage of existing exemptions in international agreements governing IP to establish regional, local, and international practices that promote more innovative, flexible uses of IP. Such practices include a research exemption for experimental uses of IP, government imposed nonexclusive licensing, anti-blocking provisions, an essential facilities doctrine, and compulsory licenses. Additional tools include an ex ante regime of compensatory liability rules for small scale innovation and sensible exceptions, particularly for science as well as general fair use provisions, to the exclusive rights of domestic copyright laws. Emerging economies will have to overcome strong economic pressure to accept more restrictive IP regimes as part of free trade agreements as well as a lack of technical expertise and internal government coordination. However, emerging economies have already accrued enough experience to be aware of the strengths and weaknesses of various IP

  1. Intellectual Capital.

    ERIC Educational Resources Information Center

    Snyder, Herbert W.; Pierce, Jennifer Burek

    2002-01-01

    This review focuses on intellectual capital and its relationship to information professionals. Discusses asset recognition; national practices and the acceptance of intellectual capital; definitions of intellectual capital; measuring intellectual capital, including multiple and single variable measures; managing intellectual capital; and knowledge…

  2. Biological diversity, indigenous knowledge, drug discovery and intellectual property rights: creating reciprocity and maintaining relationships.

    PubMed

    King, S R; Carlson, T J; Moran, K

    1996-04-01

    When new plant-derived therapeutics based on indigenous knowledge are being explored, it is important that the pharmaceutical companies return benefits to the native populations and the local governments from which the research material was obtained. When a potentially marketable plant product is being developed, it is essential that equitable agreements have already been established between the pharmaceutical companies and the people and/or countries from which this indigenous knowledge was acquired. Equally important is the commitment to provide immediate reciprocity that will enhance the welfare, the biocultural diversity and the well-being of the forest peoples. These measures should commence when a research project begins and continue during its duration. The development of these measures must be based upon the expressed needs of the indigenous communities. The relationship between the stability of the rain forest biocultural diversity, the creation and development of agro-forest resources and the long term benefits to the forest people is highlighted. Examples of initiatives taken by Shaman Pharmaceuticals Inc. and the Healing Forest Conservancy are described and discussed in the context of exploring appropriate use of intellectual property law to address the ethical issues facing all business and research groups working in the tropics.

  3. Moving Research to Patient Applications through Commercialization: Understanding and Evaluating the Role of Intellectual Property

    PubMed Central

    2010-01-01

    The advancement of research from discovery to the delivery of medical care can be limited without the support of industry to sponsor its continued development. Federal government financial support is generally crucial in early-stage development through funding from the NIH, National Science Foundation, and other federal agencies; however, government support generally stops shortly after basic research discoveries have been reported. Much of the cessation of financial support derives from the government's regulatory responsibilities, as sponsoring the commercialization of a product conflicts with regulation of the approval for clinical use of a drug or device. Furthermore, differences in goals, resources, and flexibility render government, as compared with private industry, inefficient and less responsive to market demands with regard to stream-lining the development of and enhancing the quality of products and services offered. Thus, industry and private investment provide the bridge that converts new discoveries into healthcare products that are available to consumers and patients. This conversion occurs through commercialization, which involves both high risks and high rewards. Taking advantage of the commercialization option for research development requires an understanding of the technology transfer process. This article reviews 5 topics: 1) industry motivation to invest in academic research; 2) institutional considerations in partnering with industry; 3) academia's interactions with inventors in the commercialization process; 4) the research institution's route to commercialization, and 5) the role of intellectual property and commercialization in the advancement of healthcare. PMID:20353687

  4. After thalidomide - do we have the right balance between public health and intellectual property.

    PubMed

    Feldschreiber, Peter; Breckenridge, Alasdair

    2015-01-01

    The current European regulatory and consumer protection legal framework is the legacy of Thalidomide. The disaster led to the introduction of systematic biological and clinical data to endorse the safety and efficacy of new medicines. The European Medicines Directive outlined the pre-clinical, clinical data and product information to evaluate an appropriate benefit. Risk profile of new medicines and also allowed innovative companies to extend patent protection and data/marketing exclusivity periods to compensate for the cost for research and development. However in recent years it has become apparent that the costs and time for research and development are becoming increasingly burdensome, particularly for new drugs with recently discovered mechanisms of action for cancers and neurodegenerative disorders. The costs of development and the commercial uncertainty of such products is reducing commercialisation of these medicines. There is now considerable debate in the regulatory community as to how this regulatory burden may be eased by making earlier review of benefit risk and hence earlier access to authorised medicines. The Courts are moving away from the wide definition of medicinal product to a more nuanced view of the biological and clinical therapeutic mechanisms to satisfy the 'functional' limb definition in the Directive. This may be a move away from the rigorous scientific methodology generated after thalidomide. We discuss the ethical and public health implications of this shift in policy and the implications for intellectual property mechanisms currently available to protect the commercial needs of companies.

  5. Ethnobotany/ethnopharmacology and mass bioprospecting: issues on intellectual property and benefit-sharing.

    PubMed

    Soejarto, D D; Fong, H H S; Tan, G T; Zhang, H J; Ma, C Y; Franzblau, S G; Gyllenhaal, C; Riley, M C; Kadushin, M R; Pezzuto, J M; Xuan, L T; Hiep, N T; Hung, N V; Vu, B M; Loc, P K; Dac, L X; Binh, L T; Chien, N Q; Hai, N V; Bich, T Q; Cuong, N M; Southavong, B; Sydara, K; Bouamanivong, S; Ly, H M; Thuy, Tran Van; Rose, W C; Dietzman, G R

    2005-08-22

    Ethnobotany/ethnopharmacology has contributed to the discovery of many important plant-derived drugs. Field explorations to seek and document indigenous/traditional medical knowledge (IMK/TMK), and/or the biodiversity with which the IMK/TMK is attached, and its conversion into a commercialized product is known as bioprospecting or biodiversity prospecting. When performed in a large-scale operation, the effort is referred to as mass bioprospecting. Experiences from the mass bioprospecting efforts undertaken by the United States National Cancer Institute, the National Cooperative Drug Discovery Groups (NCDDG) and the International Cooperative Biodiversity Groups (ICBG) programs demonstrate that mass bioprospecting is a complex process, involving expertise from diverse areas of human endeavors, but central to it is the Memorandum of Agreement (MOA) that recognizes issues on genetic access, prior informed consent, intellectual property and the sharing of benefits that may arise as a result of the effort. Future mass bioprospecting endeavors must take heed of the lessons learned from past and present experiences in the planning for a successful mass bioprospecting venture.

  6. Moving research to patient applications through commercialization: understanding and evaluating the role of intellectual property.

    PubMed

    Patino, Robert M

    2010-03-01

    The advancement of research from discovery to the delivery of medical care can be limited without the support of industry to sponsor its continued development. Federal government financial support is generally crucial in early-stage development through funding from the NIH, National Science Foundation, and other federal agencies; however, government support generally stops shortly after basic research discoveries have been reported. Much of the cessation of financial support derives from the government's regulatory responsibilities, as sponsoring the commercialization of a product conflicts with regulation of the approval for clinical use of a drug or device. Furthermore, differences in goals, resources, and flexibility render government, as compared with private industry, inefficient and less responsive to market demands with regard to stream-lining the development of and enhancing the quality of products and services offered. Thus, industry and private investment provide the bridge that converts new discoveries into healthcare products that are available to consumers and patients. This conversion occurs through commercialization, which involves both high risks and high rewards. Taking advantage of the commercialization option for research development requires an understanding of the technology transfer process. This article reviews 5 topics: 1) industry motivation to invest in academic research; 2) institutional considerations in partnering with industry; 3) academia's interactions with inventors in the commercialization process; 4) the research institution's route to commercialization, and 5) the role of intellectual property and commercialization in the advancement of healthcare.

  7. Who shall live when not all can live? Intellectual property in accessing and benefit-sharing influenza viruses through the World Health Organisation.

    PubMed

    Lawson, Charles

    2011-03-01

    This article addresses the development of the World Health Organisation's (WHO) arrangements for accessing viruses and the development of vaccines to respond to potential pandemics (and other lesser outbreaks). It examines the ongoing "conflict" between the United Nations' Convention on Biological Diversity (CBD) and the World Trade Organisation's Agreement on Trade Related Aspects of Intellectual Property Rights (TRIPS) in the context of the debates about the paramountcy of intellectual property, and the potential for other (equity and development) imperatives to over-ride respect for intellectual property and TRIPS. The article concludes that the same intellectual property fault lines are evident in the WHO forum as those apparent at the CBD and the WTO fora, and an ongoing failure to properly address questions of equity and development. This poses a challenge for the Australian Government in guaranteeing a satisfactory pandemic influenza preparation and response.

  8. Substance Abuse, Coping Strategies, Adaptive Skills and Behavioral and Emotional Problems in Clients with Mild to Borderline Intellectual Disability Admitted to a Treatment Facility: A Pilot Study

    ERIC Educational Resources Information Center

    Didden, Robert; Embregts, Petri; van der Toorn, Mirjam; Laarhoven, Nina

    2009-01-01

    Many clients with mild to borderline intellectual disability (ID) who are admitted to a treatment facility show serious problems in alcohol and/or drugs use. In the present case file study, we explored differences in coping strategies, adaptive skills and emotional and behavioral problems between clients who showed substance abuse and clients who…

  9. An Overview of Behavioral Strategies for Reducing Hand-Related Stereotypies of Persons with Severe to Profound Intellectual and Multiple Disabilities: 1995-2007

    ERIC Educational Resources Information Center

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff

    2009-01-01

    This paper provides an overview of behavioral strategies used for reducing hand-related stereotypies (i.e., hand/finger mouthing, eye poking, self-slapping, and other hand-to-head/body responses) of persons with severe to profound intellectual and multiple disabilities. Computerized and manual searches were conducted to identify the studies…

  10. Effects of the CD-Rom Version of the "Self-Advocacy Strategy" on Quality of Contributions in IEP Meetings of High School Students with Intellectual Disability

    ERIC Educational Resources Information Center

    Cease-Cook, Jennifer; Test, David W.; Scroggins, La' Shawndra

    2013-01-01

    This study used a multiple-probe across participants design to examine the effects of the CD-Rom version of the "Self-Advocacy Strategy" on quality of contributions in Individual Education Plan (IEP) meetings of five high school students with intellectual disability. Results indicated a functional relationship between using the CD-Rom…

  11. A Typology of Intellectual Property Management for Public Health Innovation and Access: Design Considerations for Policymakers§

    PubMed Central

    Taubman, Antony

    2010-01-01

    This paper seeks to set the practical discipline of public interest intellectual property (IP) management in public health into its broader policy context. The most immediate and direct impact of IP systems on public welfare results not from international standards nor from national legislation – though these norms are fundamentally important - but rather from the accumulated impact of numerous practical choices whether or not to seek IP protection; where and where not; and how any exclusive rights are deployed, by whom, and to what end. IP management is the essentially practical exercise of limited exclusive rights over protected subject matter, the judicious use of those rights to leverage outcomes that advance an institution's or a firm's objectives. Exclusive rights are used to construct and define knowledge-based relationships, to leverage access to technology and other necessary resources, and to enhance market-based incentives. IP management choices range across a broad spectrum, spanning public domain strategies, open or exclusive licensing, and strong exclusivity. The idea of ‘exclusive rights’, as a specific legal mechanism, can run counter to expectations of greater openness and accessibility, but actual outcomes will depend very much on how these mechanisms are used in practice. For public interest or public sector institutions concerned with health research and development, particularly the development of new medicines, IP management choices can be just as critical as they are for private firms, although a predominant institutional concentration on advancing direct public interest objectives may lead to significantly different approaches in weighing and exercising practical choices for IP management: even so, a private sector approach should not be conflated with exclusivity as an end in itself, nor need public interest IP management eschew all leverage over IP. This paper offers a tentative framework for a richer typology of those choices, to

  12. Human-tissue-related inventions: ownership and intellectual property rights in international collaborative research in developing countries.

    PubMed

    Andanda, P A

    2008-03-01

    There are complex unresolved ethical, legal and social issues related to the use of human tissues obtained in the course of research or diagnostic procedures and retained for further use in research. The question of intellectual property rights over commercially viable products or procedures that are derived from these samples and the suitability or otherwise of participants relinquishing their rights to the samples needs urgent attention. The complexity of these matters lies in the fact that the relationship between intellectual property rights and ownership or rights pertaining to the samples on which the intellectual property right is based may either be overlooked or taken for granted. What equally makes the matter complex is that samples may be obtained from participants in developing countries and exported to developed countries for analysis and research. It is important for research ethics committees to tread carefully when reviewing research protocols that raise such issues for purposes of ensuring that appropriate benefit sharing agreements, particularly with developing countries, are in place. This paper attempts to analyse the key questions related to ownership and intellectual property rights in commercially viable products derived from human tissue samples. Patent law is used as a point of reference as opposed to other forms of intellectual property rights such as industrial designs because it is the right that most inventors apply for in respect of human tissue-related inventions. The key questions are formulated following a systematic analysis of peer reviewed journal articles that have reported original investigations into relevant issues in this field. Most of the cases and reported studies that are referred to in this paper do not directly deal with HIV/AIDS research but the underlying principles are helpful in HIV/AIDS research as well. Pertinent questions, which members of ethics review committees should focus on in this regard are discussed and

  13. 78 FR 3015 - Privacy Act of 1974; U.S. Customs and Border Protection; DHS/CBP-004-Intellectual Property Rights...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... Property Rights Internal Search (IPRiS) system. IPRS provides a web-based search engine for the public to...-Intellectual Property Rights e-Recordation and Search Systems, System of Records AGENCY: Department of Homeland... Property Rights e-Recordation and Search Systems System of Records.'' This system of records allows...

  14. 75 FR 8137 - Coordination and Strategic Planning of the Federal Effort Against Intellectual Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ..., including the costs to the U.S. economy resulting from such violations, and the threats to public health and... future threats to the U.S. economy or to health and safety over the next five to ten years. Part II The... submissions from the public regarding the costs to the U.S. economy resulting from intellectual...

  15. The Controllability Beliefs Scale Used with Carers of People with Intellectual Disabilities: Psychometric Properties

    ERIC Educational Resources Information Center

    Dagnan, D.; Hull, A.; McDonnell, A.

    2013-01-01

    Background: Beliefs about the controllability of behaviour have been consistently shown to be important in understanding the responses of carers to the challenging behaviour of people with intellectual disabilities (IDs). This paper reports the reliability and validity of the Controllability Beliefs Scale (CBS), a 15-item measure of beliefs…

  16. Coping Strategies in Mothers of School-Aged Children with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Strnadova, Iva; Evans, David

    2007-01-01

    The role of the family in providing a quality education program is important for all students. For students with special educational needs, however, the role of the family is particularly critical. In such families, there can be an increased amount of stress and, at the same time, a range of coping strategies evolving. Research into the ways that…

  17. [Exclusivity of data in drug registration files and Israel's international status with regard to intellectual property rights protection].

    PubMed

    Lipschitz, Yoel; Tamir, Orly; Shemer, Joshua

    2004-12-01

    Protecting intellectual property rights encourages creativity and innovation, which are key measures for research and development of new drugs and also promotes the introduction of drugs to new markets. Over the past years, many countries have enacted laws implementing the protection of data in drug registration files. Until recently, Israel has not provided any form of data protection. Current moves focus on new legislation granting exclusivity in the marketing of innovative drugs. Although controversial, this legislation aims to secure balance in Israel between the innovative pharmaceutical companies and the public's interest in competitive generic drugs.

  18. [Evolution of the international intellectual property rights system: patent protection for the pharmaceutical industry and access to medicines].

    PubMed

    Chaves, Gabriela Costa; Oliveira, Maria Auxiliadora; Hasenclever, Lia; de Melo, Luiz Martins

    2007-02-01

    This article discusses the evolution of the international intellectual property rights system in three phases and the implications for public health, especially for the implementation of policies for access to medicines. During the first phase, characterized by the Paris and Berne Convention, signatory countries defined which technological fields should be protected (or not). Under the second phase, with the enforcement of the WTO TRIPS Agreement, countries are obliged to grant patent protection for all technological fields, including for the pharmaceutical industry. Within their national legislations, countries also have the opportunity to implement access to TRIPS flexibilities for medicines. With the third phase, characterized by the negotiation and signing of bilateral and regional free trade agreements, countries will have to implement TRIPS-plus provisions which may have negative implications for the TRIPS flexibilities as well as for policies for access to medicines. The authors conclude that the currently proposed international intellectual property rights system favors patent-holder rights and that a balance is needed between patent holders' and health rights.

  19. Intellectual disability

    MedlinePlus

    ... Failure to grow intellectually or continued infant-like behavior Lack of curiosity Problems keeping up in school Failure to adapt (adjust to new situations) Difficulty understanding and following social rules Signs of intellectual disability can range from ...

  20. Statement of Roger B. Andewelt, Deputy Assistant Attorney General, Antitrust Division, before the Subcommittee on Monopolies and Commercial Law Committee on the Judiciary, House of Representatives, concerning H.R. 557, Intellectual Property Licensing Legislation.

    ERIC Educational Resources Information Center

    Andewelt, Roger B.

    The recent increased awareness of the importance to our economy of innovation and the development of new technologies has been coupled with the crafting of new legislation to increase the level of intellectual property protection available to innovators. Because one of the key methods of encouraging the efficient use of intellectual property is…

  1. RETHINKING THE ROLE OF CLINICAL TRIAL DATA IN INTERNATIONAL INTELLECTUAL PROPERTY LAW: THE CASE FOR A PUBLIC GOODS APPROACH.

    PubMed

    Reichman, Jerome H

    2009-01-01

    This article describes the growth and consequences of new intellectual property rights given to pharmaceutical developers, and it advocates treating clinical trials as a public good. Although the soaring cost of clinical trials is well known and discussed, too little attention is given to the underlying rationale for allowing drug developers to recoup their costs through the new intellectual property rights provided in multilateral, regional, and bilateral agreements. Known in the US as "market exclusivity" and in Europe as "data exclusivity," these rights prohibit would-be generic producers from obtaining regulatory approval based on the original producers' undisclosed test data. Market and data exclusivity is codified in US and European domestic law as well as the North American Free Trade Agreement (NAFTA) and, to a lesser degree, the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). Market and data exclusivity is binding an increasing number of developing countries via Free Trade Agreements (FTAs), which hinder developing countries from manufacturing generic drugs. At a minimum, negotiators should replace the norm of exclusive control over data with a liability rule, or take and pay rule, in which generic manufacturers can use original manufacturers' clinical trial data in exchange for reasonable compensation. A more fundamental solution requires questioning the status quo of proprietary clinical trial data. The conventional wisdom is that market and data exclusivity, and drug developers' consequent ability to limit competition from generics above and beyond patent protection, are a necessary incentive for drug developers to fund ever more expensive clinical trials. Clinical trial data, however, are public goods that will be undersupplied and over protected so long as private actors provide them. Moreover, manufacturers have an incentive to present clinical trial data so that they support regulatory approval at the expense of public

  2. RETHINKING THE ROLE OF CLINICAL TRIAL DATA IN INTERNATIONAL INTELLECTUAL PROPERTY LAW: THE CASE FOR A PUBLIC GOODS APPROACH

    PubMed Central

    REICHMAN, JEROME H.

    2009-01-01

    This article describes the growth and consequences of new intellectual property rights given to pharmaceutical developers, and it advocates treating clinical trials as a public good. Although the soaring cost of clinical trials is well known and discussed, too little attention is given to the underlying rationale for allowing drug developers to recoup their costs through the new intellectual property rights provided in multilateral, regional, and bilateral agreements. Known in the US as “market exclusivity” and in Europe as “data exclusivity,” these rights prohibit would-be generic producers from obtaining regulatory approval based on the original producers’ undisclosed test data. Market and data exclusivity is codified in US and European domestic law as well as the North American Free Trade Agreement (NAFTA) and, to a lesser degree, the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). Market and data exclusivity is binding an increasing number of developing countries via Free Trade Agreements (FTAs), which hinder developing countries from manufacturing generic drugs. At a minimum, negotiators should replace the norm of exclusive control over data with a liability rule, or take and pay rule, in which generic manufacturers can use original manufacturers’ clinical trial data in exchange for reasonable compensation. A more fundamental solution requires questioning the status quo of proprietary clinical trial data. The conventional wisdom is that market and data exclusivity, and drug developers’ consequent ability to limit competition from generics above and beyond patent protection, are a necessary incentive for drug developers to fund ever more expensive clinical trials. Clinical trial data, however, are public goods that will be undersupplied and over protected so long as private actors provide them. Moreover, manufacturers have an incentive to present clinical trial data so that they support regulatory approval at the

  3. An investigation into the utilization of a constructivist teaching strategy to improve preservice elementary teachers geological content knowledge: Is there a relationship between intellectual level and content understanding?

    NASA Astrophysics Data System (ADS)

    White, Orvil L.

    these stages it is perceived that there are correct answers to questions and solutions to problems. These findings indicate the need to assess students as to their intellectual levels in order to develop effective teaching strategies to improve learning at all levels in the educational process.

  4. A macro-economic framework for evaluation of cyber security risks related to protection of intellectual property.

    PubMed

    Andrijcic, Eva; Horowitz, Barry

    2006-08-01

    The article is based on the premise that, from a macro-economic viewpoint, cyber attacks with long-lasting effects are the most economically significant, and as a result require more attention than attacks with short-lasting effects that have historically been more represented in literature. In particular, the article deals with evaluation of cyber security risks related to one type of attack with long-lasting effects, namely, theft of intellectual property (IP) by foreign perpetrators. An International Consequence Analysis Framework is presented to determine (1) the potential macro-economic consequences of cyber attacks that result in stolen IP from companies in the United States, and (2) the likely sources of such attacks. The framework presented focuses on IP theft that enables foreign companies to make economic gains that would have otherwise benefited the U.S. economy. Initial results are presented.

  5. Trade Related Aspects of Intellectual Property Rights (TRIPS) and the threat to patients: a plea for doctors to respond internationally.

    PubMed

    Faunce, T A; Drahos, P

    1998-01-01

    Many recent international agreements sponsored by bodies such as the World Trade Organisation (WTO), aim to facilitate the global free flow of goods, services and capital, by opening markets under the threat of trade sanctions. Nation States signing such agreements, in particular the Trade Related Aspects of Intellectual Property Rights (TRIPS), agree to suffer a sovereignty deficit in order to enhance their trading prospects. In the resulting reorganization of trade, medicine may be marginalised as merely another industry that must open its regional doors in the interests of global corporate productivity. We make a plea for medical organizations to lobby in appropriate international forums to create "hard" norms that ensure such international trade agreements that adequately respect the demands of fundamental ethical principles of the doctor patient relationship, principles such as medical loyalty and beneficence.

  6. Protecting intellectual property in space; Proceedings of the Aerospace Computer Security Conference, McLean, VA, March 20, 1985

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The primary purpose of the Aerospace Computer Security Conference was to bring together people and organizations which have a common interest in protecting intellectual property generated in space. Operational concerns are discussed, taking into account security implications of the space station information system, Space Shuttle security policies and programs, potential uses of probabilistic risk assessment techniques for space station development, key considerations in contingency planning for secure space flight ground control centers, a systematic method for evaluating security requirements compliance, and security engineering of secure ground stations. Subjects related to security technologies are also explored, giving attention to processing requirements of secure C3/I and battle management systems and the development of the Gemini trusted multiple microcomputer base, the Restricted Access Processor system as a security guard designed to protect classified information, and observations on local area network security.

  7. Protecting intellectual property in space; Proceedings of the Aerospace Computer Security Conference, McLean, VA, March 20, 1985

    NASA Astrophysics Data System (ADS)

    1985-07-01

    The primary purpose of the Aerospace Computer Security Conference was to bring together people and organizations which have a common interest in protecting intellectual property generated in space. Operational concerns are discussed, taking into account security implications of the space station information system, Space Shuttle security policies and programs, potential uses of probabilistic risk assessment techniques for space station development, key considerations in contingency planning for secure space flight ground control centers, a systematic method for evaluating security requirements compliance, and security engineering of secure ground stations. Subjects related to security technologies are also explored, giving attention to processing requirements of secure C3/I and battle management systems and the development of the Gemini trusted multiple microcomputer base, the Restricted Access Processor system as a security guard designed to protect classified information, and observations on local area network security.

  8. Digital Dilemma: Intellectual Property [and] The ERCIM Technical Reference Digital Library [and] International Information Gateway Collaboration [and] The Standards Fora for Online Education.

    ERIC Educational Resources Information Center

    Gladney, Henry M.; Andreoni, Antonella; Baldacci, Maria Bruna; Biagioni, Stefania; Carlesi, Carlo; Castelli, Donatella; Pagano, Pasquale; Peters, Carol; Pisani, Serena; Dempsey, Lorcan; Gardner, Tracy; Day, Michael; van der Werf, Titia; Bacsich, Paul; Heath, Andy; Lefrere, Paul; Miller, Paul; Riley, Kevin

    1999-01-01

    Includes four articles that discuss the impact of the emerging digital information infrastructure on intellectual property; the implementation of a digital library for a European consortium of national research institutions; an international information gateway collaboration; and developing standards for the description and sharing of educational…

  9. Psychometric Properties and Factor Structure of the Behavior Problems Inventory (BPI-01) in a Swedish Community Population of Adults with Intellectual Disability

    ERIC Educational Resources Information Center

    Lundqvist, Lars-Olov

    2011-01-01

    The aim of the present study was to evaluate the psychometric properties and factor structure of the Behavior Problems Inventory (BPI-01) in a community population. The Swedish version of the BPI-01 was administered by interviewing care staff of all adults (n = 915) with administratively defined intellectual disabilities (IDs) living in Orebro…

  10. Measurement Properties of the Non-Communicating Adult Pain Checklist (NCAPC): A Pain Scale for Adults with Intellectual and Developmental Disabilities, Scored in a Clinical Setting

    ERIC Educational Resources Information Center

    Lotan, M.; Moe-Nilssen, R.; Ljunggren, A. E.; Strand, L. I.

    2010-01-01

    The 18 items' Non-Communicating Adult Pain Checklist (NCAPC) has been developed from the 27 items Non-Communicating Children Pain Checklist to better capture pain behavior of adults with Intellectual and Developmental Disabilities (IDD). As part of the NCAPC's measurement properties, internal consistency, reliability and sensitivity to pain have…

  11. Attachment in Adults with Intellectual Disabilities: Preliminary Investigation of the Psychometric Properties of the Manchester Attachment Scale-Third Party Observational Measure

    ERIC Educational Resources Information Center

    Penketh, Victoria; Hare, Dougal Julian; Flood, Andrea; Walker, Samantha

    2014-01-01

    Background: The Manchester Attachment Scale-Third party observational measure (MAST) was developed to assess secure attachment style for adults with intellectual disabilities. The psychometric properties of the MAST were examined. Materials and Methods: Professional carers (N = 40) completed the MAST and measures related to the construct of…

  12. Intellectual Property Law Confers Rights in Respect of Online Distance Education, yet Most Learning Resources Are Still Free--Truth or Fiction?

    ERIC Educational Resources Information Center

    Mann, Bruce L.

    2009-01-01

    Educational technologists might well describe online distance education as "a series of instructional events over the Internet that find their expression as learning events in a student". As a legal construct however, "online distance education" is simply "the intellectual property of its owner". This description is…

  13. Substance abuse, coping strategies, adaptive skills and behavioral and emotional problems in clients with mild to borderline intellectual disability admitted to a treatment facility: a pilot study.

    PubMed

    Didden, Robert; Embregts, Petri; van der Toorn, Mirjam; Laarhoven, Nina

    2009-01-01

    Many clients with mild to borderline intellectual disability (ID) who are admitted to a treatment facility show serious problems in alcohol and/or drugs use. In the present case file study, we explored differences in coping strategies, adaptive skills and emotional and behavioral problems between clients who showed substance abuse and clients who did not. There were no differences in adaptive skills between groups. However, compared to clients without substance abuse, those who abused substances showed a more palliative coping style, and had more severe emotional and behavior problems such as anxiety/depression and intrusive thoughts and aggressive and antisocial behaviors. Implications for treatment are discussed.

  14. Examining Emerging Strategies to Prevent Sexual Violence: Tailoring to the Needs of Women with Intellectual and Developmental Disabilities

    ERIC Educational Resources Information Center

    Stevens, Bethany

    2012-01-01

    Sexual violence (SV) negatively impacts women with disabilities disproportionately, especially those with intellectual and/or developmental disabilities (IDD). The 2 populations are included in this article as there are overlaps in diagnostic criteria as well as similar risk factors associated with the experience of SV. Despite lacking…

  15. Video Modeling and Prompting: A Comparison of Two Strategies for Teaching Cooking Skills to Students with Mild Intellectual Disabilities

    ERIC Educational Resources Information Center

    Taber-Doughty, Teresa; Bouck, Emily C.; Tom, Kinsey; Jasper, Andrea D.; Flanagan, Sara M.; Bassette, Laura

    2011-01-01

    Self-operated video prompting and video modeling was compared when used by three secondary students with mild intellectual disabilities as they completed novel recipes during cooking activities. Alternating between video systems, students completed twelve recipes within their classroom kitchen. An alternating treatment design with a follow-up and…

  16. Development and Psychometric Properties of an Assessment for Persons with Intellectual Disability--The InterRAI ID

    ERIC Educational Resources Information Center

    Martin, Lynn; Hirdes, John P.; Fries, Brant E.; Smith, Trevor F.

    2007-01-01

    This paper describes the development of the interRAI-Intellectual Disability (interRAI ID), a comprehensive instrument that assesses all key domains of interest to service providers relative to a person with an intellectual disability (ID). The authors report on the reliability and validity of embedded scales for cognition, self-care, aggression,…

  17. Educating for Intellectual Virtues: From Theory to Practice

    ERIC Educational Resources Information Center

    Baehr, Jason

    2013-01-01

    After a brief overview of what intellectual virtues are, I offer three arguments for the claim that education should aim at fostering "intellectual character virtues" like curiosity, open-mindedness, intellectual courage, and intellectual honesty. I then go on to discuss several pedagogical and related strategies for achieving this aim. (Contains…

  18. Intellectual Disability

    MedlinePlus

    ... children; learn to talk later, or have trouble speaking, find it hard to remember things, not understand ... intellectual functioning ); and whether the person has the skills he or she needs to live independently (called ...

  19. Implementing Intellectual Property of Pharmaceuticals in Middle-Income Countries: A Case Study of Patent Regulation in Brazil.

    PubMed

    da Fonseca, Elize Massard; Bastos, Francisco Inácio

    2016-06-01

    The protection of pharmaceutical intellectual property (IP) rights is one of the most controversial debates in contemporary public health as countries have to balance incentives for drug development with the necessity of providing life-saving drugs. Compliance with IP protections is mandatory for members of the World Trade Organization (WTO). However, because of the costs associated with IP implementation we should expect late and/or poor implementation in middle-income countries. Surprisingly, this was not the case in Brazil. The country not only just fully implemented the WTO's requirement but declined the grace period granted for countries to adapt and included extra IP protections, going against a coalition of local industrialists and activists. Notwithstanding, as the consequences of IP regulations unfolds, Brazil also promoted new alliances that tailored and adjusted the regulations toward public health. We demonstrate that arguments of foreign pressure and lobbying are exaggerated and call attention to domestic shifts, long-term processes of regulatory decision, and political dynamics happening at the local level. By analyzing the case of Brazil, we provide a nuanced contribution to the discussion of IP implementation in middle-income countries and call attention to new models of government-society interactions in regulatory policy.

  20. 77 FR 42765 - Request of the U.S. Intellectual Property Enforcement Coordinator for Public Comments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... property rights and ensuring the safety of products entering the stream commerce, e.g., U.S. Food and Drug... utilizes Internet based e- commerce and mobile platforms for transactions, the number of shipments sent... site is a Federal E-Government Web site that allows the public to find, review and submit comments...

  1. 76 FR 64075 - Request for Comments on Intellectual Property Enforcement in China

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... (IP) in that country. China's patent and trademark offices are now among the largest in the world in.... SUPPLEMENTARY INFORMATION: As the second largest economy in the world, China continues to attract U.S... Property Office (SIPO) of the People's Republic of China is now one of the largest patent office in...

  2. [Specificities of patent protection in the pharmaceutical industry: modalities and traits of intellectual property].

    PubMed

    Jannuzzi, Anna Haydée Lanzillotti; Vasconcellos, Alexandre Guimarães; de Souza, Cristina Gomes

    2008-06-01

    Different forms of protection for inventions in the pharmaceutical industry point to strategies for the perpetuation of patent protection. Based on a literature review showing the specificities of patenting in the industry, the article provides a brief history of drug patents in Brazil, a discussion of patentable and non-patentable inventions, and the modalities and traits of patent protection that aim to extend the temporary monopoly granted under the patent. Such strategies include patents targeting polimorphs and optical isomers of drugs and drug combinations and specific clinical preparations, increasingly present in the drug patent claims filed by pharmaceutical companies. The study's objective is to discuss the specificities of drug patent claims in order to help develop expertise in the area and discuss the impact of expanding the scope of patent protection. In conclusion, while the tendency to expand towards more a permissive protective scope could produce opportunities for Brazilian national inventors, it could also be harmful to a policy for access to medicines.

  3. Faster and Cheaper: Creating a Culture of Innovation for AFRL Intellectual Property

    DTIC Science & Technology

    2016-01-01

    graphs showing how technology growth is moving at an exponential rate, see Ray Kurzweil, The Singularity is Near (New York, NY: Viking Books, 2005...of the Federal Management Regulation regarding restrictions on animals in federal buildings.79 Also, options to include interns and volunteers in...Corporation,” Harvard Business Review 80, no. 8, May 2009, 105. 79 “What is the policy concerning dogs and other animals on Federal property? No person

  4. Development of an Intellectual Property Strategy: Research Notes to Support Department of Defense Programs

    DTIC Science & Technology

    2014-09-01

    reproductions and derivative works. External use:* This material may be reproduced in its entirety, without modification, and freely distributed...granted to anyone who invents or discovers and asexually reproduces any distinct and new variety of plant [USPTO 2011] 2.1.2 Terms of Patent...for certain license rights, such as use, reproduction , display, performance, modification, disclosure, and release of the work. Licenses define the

  5. Development of an Intellectual Property Strategy: Research Notes to Support Department of Defense Programs

    DTIC Science & Technology

    2014-10-01

    is granted, provided the copyright and “No Warranty” statements are included with all reproductions and derivative works. External use:* This...and asexually reproduces any distinct and new variety of plant [USPTO 2011] 2.1.2 Terms of Patent Ownership An inventor must apply for a patent... reproduction , display, performance, modification, disclosure, and release of the work. Licenses define the rights and terms between the parties to

  6. Skill Acquisition of the Prior Art Search for Intellectual Property Special Talented People

    NASA Astrophysics Data System (ADS)

    Hiratsuka, Masahiro

    The comparative analysis of the prior art search was made using the training program which National Center for Industrial Property Information and Training performs. The correct answer rate was high when longer years of experience, experiences such as search/retrieval in charge or database. Depending on a technical field, there was the feature according to consideration of search/retrieval or timing of doing prior art search. The improvement in skill of the prior art search according to a technical field and the personnel training for it are important as a premise for protecting valuable invention and performing the practical use. The comparative analysis beyond technical fields is needed.

  7. Properties of a mixed ESS candidate in continuous strategy sets.

    PubMed

    Yaniv, Osnat

    2006-02-21

    An evolutionarily stable strategy (ESS) is a strategy that if almost all members of the population adopt, then this population cannot be invaded by any mutant strategy. An ESS is not necessarily a possible end point of the evolutionary process. Moreover, there are cases where the population evolves towards a strategy that is not an ESS. This paper studies the properties of a unique mixed ESS candidate in a continuous time animal conflict. A member of a group sized three finds itself at risk and needs the assistance of another group member to be saved. In this conflict, a player's strategy is to choose the probability distribution of the interval between the beginning of the game and the moment it assists the player which is at risk. We first assume that a player is only allowed to choose an exponential distribution, and show that in this case the ESS candidate is an attracting ESS; the population will always evolve towards this strategy, and once it is adopted by most members of the population it cannot be invaded by mutant strategies. Then, we extend the strategy sets and allow a player to choose any continuous distribution. We show that although this ESS candidate may no longer be an ESS, under fairly general conditions the population will tend towards it. This is done by characterizing types of strategies that if established in the population, can be invaded by this ESS candidate, and by presenting possible paths of transition from other types of common strategies to this ESS candidate.

  8. Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability

    PubMed Central

    O'Brien, Janelle E.; Meisler, Miriam H.

    2013-01-01

    The sodium channel Nav1.6, encoded by the gene SCN8A, is one of the major voltage-gated channels in human brain. The sequences of sodium channels have been highly conserved during evolution, and minor changes in biophysical properties can have a major impact in vivo. Insight into the role of Nav1.6 has come from analysis of spontaneous and induced mutations of mouse Scn8a during the past 18 years. Only within the past year has the role of SCN8A in human disease become apparent from whole exome and genome sequences of patients with sporadic disease. Unique features of Nav1.6 include its contribution to persistent current, resurgent current, repetitive neuronal firing, and subcellular localization at the axon initial segment (AIS) and nodes of Ranvier. Loss of Nav1.6 activity results in reduced neuronal excitability, while gain-of-function mutations can increase neuronal excitability. Mouse Scn8a (med) mutants exhibit movement disorders including ataxia, tremor and dystonia. Thus far, more than ten human de novo mutations have been identified in patients with two types of disorders, epileptic encephalopathy and intellectual disability. We review these human mutations as well as the unique features of Nav1.6 that contribute to its role in determining neuronal excitability in vivo. A supplemental figure illustrating the positions of amino acid residues within the four domains and 24 transmembrane segments of Nav1.6 is provided to facilitate the location of novel mutations within the channel protein. PMID:24194747

  9. Strategies Used by Intellectually Gifted Students to Cope with Stress during Their Participation in a High School International Baccalaureate Program

    ERIC Educational Resources Information Center

    Shaunessy, Elizabeth; Suldo, Shannon M.

    2010-01-01

    Individuals respond to threats to affiliation and achievement needs through drawing on a repertoire of coping strategies specific to a given situation. Gifted adolescents in college-preparatory high school programs may be faced with novel stressors, and may have unique coping strategies to manage these challenges. The current study considers…

  10. Intellectual Decline.

    ERIC Educational Resources Information Center

    Guilford, J.P.

    In investigations of decline of intellectual status with age, cross-sectional and longitudinal studies give divergent results--the former show almost universal declines in test performances among older groups while the latter often show gains. Although few structure-of-intellect (SI) factors have been explored in relation to adult ages, two kinds…

  11. Psychometric Properties of Two Measures of Crisis and Distress in Parents of Children with Intellectual and Developmental Disabilities

    ERIC Educational Resources Information Center

    Benninger, Tara L.; Witwer, Andrea N.

    2017-01-01

    Introduction: Parents and their children with Intellectual and Developmental Disabilities (IDD) are under significant amounts of stress (Lecavalier, Leone & Wiltz, 2006). When stress escalates to crisis, some children with IDD are admitted to the emergency department or an inpatient unit. While existing measures evaluate stress over time, we…

  12. Has the implementation of the TRIPS Agreement in Latin America and the Caribbean produced intellectual property legislation that favours public health?

    PubMed Central

    Oliveira, Maria Auxiliadora; Bermudez, Jorge Antonio Zepeda; Chaves, Gabriela Costa; Velásquez, Germán

    2004-01-01

    OBJECTIVE: The World Trade Organization's Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement establishes minimum standards for intellectual property rights, including patent protection for pharmaceuticals; therefore, it may make it difficult for developing countries to gain access to medicines, especially those countries that are the least developed. This study aims to determine whether implementation of the TRIPS Agreement in Latin American and Caribbean countries has generated patent legislation that is sensitive to public health needs. METHODS: Legislation in 11 Latin American and Caribbean countries was analysed. The variables considered in the analysis were: the term of patents issued, patentable subject matter, transition periods (that is, time until legislation was enacted), reversal of the burden of proof of patent infringement, exhaustion of rights, compulsory licensing and the early working exception (which allows a country to complete all procedures necessary to register a generic product before the original patent expires). FINDINGS: By 2000, all of the countries studied had reformed their legislation to conform to the agreement. Brazil and Argentina used the transition period until 2005 to grant patents in the pharmaceutical industry. All countries, except Panama, made use of the safeguards and flexibilities available through the agreement by including mechanisms for compulsory licensing in their legislation. Argentina; Bolivia, Colombia, Ecuador, Peru and Venezuela (countries that represented the Andean community); the Dominican Republic; and Panama included mechanisms to allow parallel importation. Mexico did not. Brazil only permits parallel importation after a compulsory licence has been issued. The early working exception is included in legislation in Brazil and the Dominican Republic. CONCLUSION: The countries in this study did not incorporate all of the mechanisms allowed for by the Agreement and are not adequately using the

  13. The dilemma of intellectual property rights for pharmaceuticals: the tension between ensuring access of the poor to medicines and committing to international agreements.

    PubMed

    Cohen, Jillian Clare; Illingworth, Patricia

    2003-05-01

    In this paper, we provide an overview of how the outcomes of the Uruguay Round affected the application of pharmaceutical intellectual property rights globally. Second, we explain how specific pharmaceutical policy tools can help developing states mitigate the worst effects of the TRIPS Agreement. Third, we put forward solutions that could be implemented by the World Bank to help overcome the divide between creating private incentives for research and development of innovative medicines and ensuring access of the poor to medicine. Fourth, we evaluate these solutions on the basis of utilitarian considerations and urge that equitable pricing is morally preferable to the other solutions.

  14. Review department programs related to intellectual property and technology transfer to ensure department resources are leveraged to the economic benefit of the US

    SciTech Connect

    Martin, S.W.

    1995-02-01

    Review domestic and international policy, US Intellectual Property (IP) and Technology Transfer (TT) legislation, and related Department of Energy (DOE) programs to ensure Department resources are leveraged to the benefit of the US economy. Mapping such processes should determine if/how foreign governments and/or foreign owned or controlled enterprises, specifically Japanese and to a lessor extent other Pacific Rim nations, are able to access and at times leverage US technology to their benefit. This process will also generate lessons learned that should be useful to government and industry alike in the area of TT. The review will concentrate on technology innovations developed or funded by the Department.

  15. The use of agrobiodiversity for plant improvement and the intellectual property paradigm: institutional fit and legal tools for mass selection, conventional and molecular plant breeding.

    PubMed

    Batur, Fulya; Dedeurwaerdere, Tom

    2014-12-01

    Focused on the impact of stringent intellectual property mechanisms over the uses of plant agricultural biodiversity in crop improvement, the article delves into a systematic analysis of the relationship between institutional paradigms and their technological contexts of application, identified as mass selection, controlled hybridisation, molecular breeding tools and transgenics. While the strong property paradigm has proven effective in the context of major leaps forward in genetic engineering, it faces a systematic breakdown when extended to mass selection, where innovation often displays a collective nature. However, it also creates partial blockages in those innovation schemes rested between on-farm observation and genetic modification, i.e. conventional plant breeding and upstream molecular biology research tools. Neither overly strong intellectual property rights, nor the absence of well delineated protection have proven an optimal fit for these two intermediary socio-technological systems of cumulative incremental innovation. To address these challenges, the authors look at appropriate institutional alternatives which can create effective incentives for in situ agrobiodiversity conservation and the equitable distribution of technologies in plant improvement, using the flexibilities of the TRIPS Agreement, the liability rules set forth in patents or plant variety rights themselves (in the form of farmers', breeders' and research exceptions), and other ad hoc reward regimes.

  16. Bio-prospecting or bio-piracy: intellectual property rights and biodiversity in a colonial and postcolonial context.

    PubMed

    Merson, J

    2000-01-01

    Despite the rhetoric of decolonization following World War II, developing countries are, if anything, more dependent now on the science and technology of the developed world than they were in colonial times. This has led some critics to describe their situation as "neo-colonial." This paper will explore the issue in relation to the biotechnology industry, and to the 1993 United Nations Convention on Biodiversity. This convention challenged the assumption that the earth's biological and genetic resources are part of the "global commons" by giving property rights over these resources to the nation-states. While the objective of encouraging states to conserve biodiversity is universally endorsed, the strategy of using property law to do so is not. The search for new genetic and biological resources has become a major priority for the agrichemical and pharmaceutical industries, and despite continuation of the colonial tradition of appropriating indigenous knowledge and resources, new and more equitable models are being explored and developed within the convention's framework. These strategies, while controversial, offer the hope of a new and more just "International Genetic Order."

  17. Health Status and Coping Strategies among Older Parent-Carers of Adults with Intellectual Disabilities in an Australian Sample

    ERIC Educational Resources Information Center

    Llewellyn, Gwynnyth; McConnell, David; Gething, Lindsay; Cant, Rosemary; Kendig, Hal

    2010-01-01

    Background: Older parent-carers in Australia are the subject of increasing policy and practice attention due to concerns about their ongoing ability to care in the light of their own ageing and the ageing of their adult son or daughter. This paper examines health status and the coping strategies of a group of older Australian parents caring for an…

  18. Modeling the Occupational/Career Decision-Making Processes of Intellectually Gifted Adolescents: A Competing Models Strategy

    ERIC Educational Resources Information Center

    Jung, Jae Yup

    2014-01-01

    This study developed and empirically tested two related models of the occupational/career decision-making processes of gifted adolescents using a competing models strategy. The two models that guided the study, which acknowledged cultural orientations, social influences from the family, occupational/career values, and characteristics of…

  19. Impact of the trade-related aspects of intellectual property rights (TRIPS) agreement on India as a supplier of generic antiretrovirals.

    PubMed

    Babovic, Sonja; Wasan, Kishor M

    2011-03-01

    This is a commentary on how the trade-related aspects of intellectual property rights (TRIPS) agreement has impacted India as a supplier of generic antiretrovirals (ARVs). We provide a systematic review of the issues related to the TRIPS agreement that affects India. This includes discussion around (a) the legal landscape underpinning India as a supplier of generic ARVs; (b) supply of second-line ARVs; and (c) the future of generic drug production in India. The proclamation into force of TRIPS-compliant intellectual property law in India is likely to affect its position as a supplier of affordable ARVs, especially drugs brought to market after 2005. Currently, mechanisms exist for the generic production of almost all ARVs in India, including second-line drugs; however, the manufacture of these drugs by generic pharmaceutical companies may require additional market incentives. Compulsory licensing may emerge as an additional mechanism by which India can provide affordable versions of patented drugs to Least Developed Countries (LDCs).

  20. Psychometric Properties of the "Aberrant Behavior Checklist," the "Anxiety, Depression and Mood Scale," the "Assessment of Dual Diagnosis" and the "Social Performance Survey Schedule" in Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Rojahn, Johannes; Rowe, Ellen W.; Kasdan, Shana; Moore, Linda; van Ingen, Daniel J.

    2011-01-01

    Progress in clinical research and in empirically supported interventions in the area of psychopathology in intellectual disabilities (ID) depends on high-quality assessment instruments. To this end, psychometric properties of four instruments were examined: the "Aberrant Behavior Checklist" (ABC), the "Assessment of Dual…

  1. Intellectual Property Rights in an Electronic Age. Proceedings of the Library of Congress Network Advisory Committee Meeting (Washington, D.C., April 22-24, 1987). Network Planning Paper No. 16.

    ERIC Educational Resources Information Center

    Harriman, Sigrid G., Ed.

    This document presents the proceedings of a conference on the issues of intellectual property rights in a technology-driven environment. Following an introduction which summarizes the conference presentations and discussions, copies of the five presentations are provided: (1) "The OTA (Office of Technology Assessment) Report on Intellectual…

  2. Consumer Benefits of Today's Digital Rights Management (DRM) Solutions. Hearing before the Subcommittee on Courts, the Internet, and Intellectual Property of the Committee on the Judiciary. House of Representatives, One Hundred Seventh Congress, Second Session (June 5, 2002).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on the Judiciary.

    The Subcommittee on Courts, the Internet, and Intellectual Property, Committee on the Judiciary met, pursuant to call, at 2:15 p.m., in Room 2141, Rayburn House Office Building, to review the consumer benefits of today's digital rights management (DRM) solutions. The Honorable Howard Coble, a Representative in Congress from North Carolina and…

  3. The psychometric properties of the Socio-Moral Reflection Measure--Short Form and the Moral Theme Inventory for men with and without intellectual disabilities.

    PubMed

    Langdon, Peter E; Murphy, Glynis H; Clare, Isabel C H; Palmer, Emma J

    2010-01-01

    Drawing conclusions from the literature regarding the moral development of people with intellectual disabilities (IDs) is difficult because of the use of unstandardised and idiosyncratic measures. In order to address this short-coming, a moral reasoning production measure (the Socio-Moral Reflection Measure--Short Form; SRM-SF) and a recognition measure (the Moral Theme Inventory; MTI) were presented to men with and without IDs who had no known history of engaging in illegal behaviour. The instruments were completed on two occasions, separated by a two-week interval, in order to investigate their basic psychometric properties. The results indicated that there was a strong relationship between the MTI and the SRM-SF, suggesting that the MTI has convergent validity. The internal consistency of the MTI and the SRM-SF ranged from moderate to substantial for both men with and without IDs. However, the test-retest reliability of the MTI was poor for men with IDs, while it was good for men without IDs. The test-retest reliability of the SRM-SF was good for both men with and without IDs. Comparison of the moral reasoning abilities of men with and without IDs suggested that many of the differences between the two groups could be accounted for by general intellectual functioning. The exception was overall score on the SRM-SF and moral reasoning in relation to the law, where men with IDs scored at stage 2(1), when intelligence was controlled. The results were interpreted by suggesting that the relationship between moral reasoning and illegal behaviour may take an inverted U curve shape, moderated by intelligence.

  4. The Relations between Number Property Strategies, Working Memory, and Multiplication in Elementary Students

    ERIC Educational Resources Information Center

    Liu, Ru-De; Ding, Yi; Gao, Bing-Cheng; Zhang, Dake

    2015-01-01

    This study aimed to examine the relations among property strategies, working memory, and multiplication tasks with 101 Chinese fourth-grade students. Two multiplication property strategies (associative and distributive) were compared with no strategy and demonstrated differentiated effects on students' accuracy and reaction time. Associative…

  5. An initial assessment of the psychometric properties of the Complicated Grief Questionnaire for People with Intellectual Disabilities (CGQ-ID).

    PubMed

    Guerin, Suzanne; Dodd, Philip; Tyrell, Janette; McEvoy, John; Buckley, Sarah; Hillery, John

    2009-01-01

    Given the research evidence that people with intellectual disability (ID) do grieve following bereavement, the present study aimed to describe and gather preliminary psychometric data for a version of the Inventory of Complicated Grief [Prigerson, H. G., Maciejewski, P. K., Reynolds, C. F., Bierhals, A. J., Newsom, J. T., Fasiczka, A., et al. (1995). Inventory of Complicated Grief: A scale to measure maladaptive symptoms of loss. Psychiatry Research, 59, 65-79] adapted for use with this population. Carers completed the Complicated Grief Questionnaire for People with ID (CGQ-ID) for 76 individuals with ID, half of whom had experienced a parental bereavement within the last 2 years. The final scale and subscales (Separation Distress and Traumatic Grief) showed very good internal and inter-rater reliability and distinguished between the two groups. While the findings suggest that the CGQ-ID is suitable for identifying complicated grief-type symptoms among adults with ID, further research must be conducted to ascertain whether the findings can be replicated.

  6. Modifications of the One-More-Than Technique: A Comparison of Two Strategies for Teaching Purchasing Skills to Students with Intellectual Disability in Taiwan

    ERIC Educational Resources Information Center

    Hsu, Guo-Liang; Tang, Jung-Chang; Hwang, Wu-Yuin; Li, Yung-Chang; Hwang, Wu-Yuin; Li, Yung-Chang; Hung, Jung-Chao; Wei, Chun-Hwa

    2016-01-01

    The demands of money-counting skills potentially limit individuals with intellectual disability (ID) to master the one-more-than technique, particularly in Taiwan, which requires high daily minimum living expense for supporting an individual's daily life. Employing a multiple treatment design across price ranges and settings, this study compared…

  7. Reduce, Manage or Cope: A Review of Strategies for Training School Staff to Address Challenging Behaviours Displayed by Students with Intellectual/Developmental Disabilities

    ERIC Educational Resources Information Center

    Stoesz, Brenda M.; Shooshtari, Shahin; Montgomery, Janine; Martin, Toby; Heinrichs, Dustin J.; Douglas, Joyce

    2016-01-01

    Members of a knowledge translation and exchange (KTE) research team assessed the training needs of the teaching staff at a school for individuals with intellectual/developmental disabilities (IDD). In response to this need, KTE researchers retrieved peer-reviewed articles for training staff working with individuals with IDD who exhibit challenging…

  8. Effects of the "TOUCHMATH" Program Compared to a Number Line Strategy to Teach Addition Facts to Middle School Students with Moderate Intellectual Disabilities

    ERIC Educational Resources Information Center

    Fletcher, Dale; Boon, Richard T.; Cihak, David F.

    2010-01-01

    The purpose of this study was to systematically replicate and extend previous studies of the TOUCHMATH program, a multi-sensory mathematics program (Bullock, Pierce, & McClellan, 1989). Three middle school students with moderate and multiple disabilities (e.g., autism and moderate intellectual disabilities) participated. Students were taught how…

  9. Personality Dimensions, Religious Tendencies and Coping Strategies as Predictors of General Health in Iranian Mothers of Children with Intellectual Disability: A Comparison with Mothers of Typically Developing Children

    ERIC Educational Resources Information Center

    Mirsaleh, Y. R.; Rezai, H.; Khabaz, M.; Afkhami Ardekani, I.; Abdi, K.

    2011-01-01

    Background: Challenges related to rearing children with intellectual disability (ID) may cause mothers of these children to have mental health status problems. Method: A total of 124 mothers who had a child with ID and 124 mothers of typically developing children were selected using random sampling. Data were collected using General health…

  10. Following through to the End: The Use of Inclusive Strategies to Analyse and Interpret Data in Participatory Action Research with Individuals with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Kramer, Jessica M.; Kramer, John C.; Garcia-Iriarte, Edurne; Hammel, Joy

    2011-01-01

    Background: Scholars have called for research approaches that actively include and are driven by people with intellectual disabilities, but the process of inclusive data analysis has been scarcely documented in the literature. This paper demonstrates the process university researchers and a group of self-advocates used to analyse and interpret…

  11. Adaptation and Psychometric Properties of the Self-Efficacy/Social Support for Activity for Persons with Intellectual Disability Scale (SE/SS-AID) in a Spanish Sample

    ERIC Educational Resources Information Center

    Cuesta-Vargas, Antonio Ignacio; Paz-Lourido, Berta; Lee, Miyoung; Peterson-Besse, Jana J.

    2013-01-01

    Background: In this study we aimed to develop a Spanish version of the Self-Efficacy/Social Support Scales for Activity for persons with Intellectual Disability (SE/SS-AID). Method: A cross-sectional study was carried out in a sample of 117 individuals with intellectual disability (ID). The SE/SS-AID scales were translated into Spanish and their…

  12. 76 FR 55744 - Currently Approved Information Collection: Comment Request for Application for Intellectual...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... Intellectual Property Use Forms AGENCY: United States Mint. ACTION: Notice and request for comments. SUMMARY... for Intellectual Property Use forms. DATES: Written comments should be received on or before November... INFORMATION: Title: Applications for Intellectual Property Use. OMB Number: 1525-0013. Abstract:...

  13. To be or not IP? Exploring limits within patent law for the constitutionalization of intellectual property rights and the governance of synthetic biology in human health.

    PubMed

    Schneider, Ingrid

    2012-01-01

    The article explores limits within patent law for the constitutionalization of Intellectual Property Rights and the governance of synthetic biology in human health. To this end, it starts by explaining the inherent rationales of two fundamental limits within European patent law, namely (1) the boundary between discovery and invention (Art. 52 EPC); (2) the ordre public and public policy clause (Art. 53 (a) EPC). Both these exclusions from patent eligibility bear a normative function but rely on opposing inherent logics, functions, and regulatory aims. While in the first type of logics, "enabling access for all" is the guiding principle, in the second, converse logics, no one should have access to the technological knowledge in question. The second part contends that decisions on whether and how to grant patents in synthetic biology are not independent from institutional frameworks: The arena in which synthetic biology patenting will be dealt with will be decisive for whether and how boundaries will be deployed. From a political science perspective, the administrative, legislative and judicial arena can be distinguished. If synthetic biology will be negotiated in the legislative arena, in particular in the European Parliament, the probabilities will be higher that either the discovery clause or the ordre public clause will be applied. In contrast, patent offices and courts have, at least in the past decades, employed a narrow interpretation of these absolute exemptions from patentability and hardly ever used them. The third part asserts that metaphoric framing of synthetic biology is another crucial factor for patentability questions. Semantic framing may relate to the articulation and mobilization of consent or dissent, and thus public acceptance of synthetic biology. Whether applications of synthetic biology are conceived as "natural" or "synthetic" DNA may have an influence on whether patenting might become contested as "patenting life" or accepted as novel, and

  14. [Conceptual foundations of creation of branch database of technology and intellectual property rights owned by scientific institutions, organizations, higher medical educational institutions and enterprises of healthcare sphere of Ukraine].

    PubMed

    Horban', A Ie

    2013-09-01

    The question of implementation of the state policy in the field of technology transfer in the medical branch to implement the law of Ukraine of 02.10.2012 No 5407-VI "On Amendments to the law of Ukraine" "On state regulation of activity in the field of technology transfers", namely to ensure the formation of branch database on technology and intellectual property rights owned by scientific institutions, organizations, higher medical education institutions and enterprises of healthcare sphere of Ukraine and established by budget are considered. Analysis of international and domestic experience in the processing of information about intellectual property rights and systems implementation support transfer of new technologies are made. The main conceptual principles of creation of this branch database of technology transfer and branch technology transfer network are defined.

  15. Intellectual property rights and challenges for development of affordable human papillomavirus, rotavirus and pneumococcal vaccines: Patent landscaping and perspectives of developing country vaccine manufacturers.

    PubMed

    Chandrasekharan, Subhashini; Amin, Tahir; Kim, Joyce; Furrer, Eliane; Matterson, Anna-Carin; Schwalbe, Nina; Nguyen, Aurélia

    2015-11-17

    The success of Gavi, the Vaccine Alliance depends on the vaccine markets providing appropriate, affordable vaccines at sufficient and reliable quantities. Gavi's current supplier base for new and underutilized vaccines, such as the human papillomavirus (HPV), rotavirus, and the pneumococcal conjugate vaccine is very small. There is growing concern that following globalization of laws on intellectual property rights (IPRs) through trade agreements, IPRs are impeding new manufacturers from entering the market with competing vaccines. This article examines the extent to which IPRs, specifically patents, can create such obstacles, in particular for developing country vaccine manufacturers (DCVMs). Through building patent landscapes in Brazil, China, and India and interviews with manufacturers and experts in the field, we found intense patenting activity for the HPV and pneumococcal vaccines that could potentially delay the entry of new manufacturers. Increased transparency around patenting of vaccine technologies, stricter patentability criteria suited for local development needs and strengthening of IPRs management capabilities where relevant, may help reduce impediments to market entry for new manufacturers and ensure a competitive supplier base for quality vaccines at sustainably low prices.

  16. Molecular isotopic engineering (MIE): industrial manufacture of naproxen of predetermined stable carbon-isotopic compositions for authenticity and security protection and intellectual property considerations

    NASA Astrophysics Data System (ADS)

    Jasper, J. P.; Farina, P.; Pearson, A.; Mezes, P. S.; Sabatelli, A. D.

    2016-05-01

    Molecular Isotopic Engineering (MIE) is the directed stable-isotopic synthesis of chemical products for reasons of product identification and of product security, and also for intellectual property considerations. We report here a generally excellent correspondence between the observed and predicted stable carbon-isotopic (δ13C) results for a successful directed synthesis of racemic mixture from its immediate precursors. The observed results are readily explained by the laws of mass balance and isotope mass balance. Oxygen- and hydrogen isotopic results which require an additional assessment of the effects of O and H exchange, presumably due to interaction with water in the reaction solution, are addressed elsewhere. A previous, cooperative study with the US FDA-DPA showed that individual manufacturers of naproxen could readily be differentiated by their stable-isotopic provenance (δ13C, δ18O, and δD ref. 1). We suggest that MIE can be readily employed in the bio/pharmaceutical industry without alteration of present manufacturing processes other than isotopically selecting and/or monitoring reactants and products.

  17. Parental social support, coping strategies, resilience factors, stress, anxiety and depression levels in parents of children with MPS III (Sanfilippo syndrome) or children with intellectual disabilities (ID).

    PubMed

    Grant, Sheena; Cross, Elaine; Wraith, James Edmond; Jones, Simon; Mahon, Louise; Lomax, Michelle; Bigger, Brian; Hare, Dougal

    2013-03-01

    Mucopolysaccharidosis type III (MPS III, Sanfilippo syndrome) is a lysosomal storage disorder, caused by a deficiency in one of four enzymes involved in the catabolism of the glycosaminoglycan heparan sulphate. It is a degenerative disorder, with a progressive decline in children's intellectual and physical functioning. There is currently no cure for the disorder. To date there is a paucity of research on how this disorder impacts parents psychological functioning. Specifically, research in the area has failed to employ adequate control groups to assess if the impact of this disorder on parents psychological functioning differs from parenting a child with intellectual disability (ID). The current study examined child behaviour and parental psychological functioning in 23 parents of children with MPS III and 23 parents of children with ID. Parents completed postal questionnaires about their child's behaviour and abilities and their own psychological functioning. Parents of children with MPS III reported fewer behavioural difficulties as their child aged, more severe level of intellectual disability, and similar levels of perceived social support, coping techniques, stress, anxiety and depression levels as parents of children with ID. Both groups of parents scored above the clinical cut off for anxiety and depression. Parents of children with MPS III rated themselves as significantly less future-orientated and goal directed than parents of children with ID. Services should develop support packages for parents of children with MPS III that incorporate an understanding of the unique stressors and current-difficulty approach of this population. Future research should examine gender differences between parental psychological functioning, using mixed qualitative and quantitative approaches, and utilise matched developmental level and typically developing control groups.

  18. Teaching Reading for Students with Intellectual Disabilities: A Systematic Review

    ERIC Educational Resources Information Center

    Alnahdi, Ghaleb Hamad

    2015-01-01

    A systematic review of the literature related to instructional strategies to improve reading skills for students with intellectual disabilities was conducted. Studies reviewed were within three categories; early reading approaches, comprehensive approaches, and one method approach. It was concluded that students with intellectual disabilities are…

  19. Industry-university collaborations in Canada, Japan, the UK and USA--with emphasis on publication freedom and managing the intellectual property lock-up problem.

    PubMed

    Kneller, Robert; Mongeon, Marcel; Cope, Jeff; Garner, Cathy; Ternouth, Philip

    2014-01-01

    As industry-university collaborations are promoted to commercialize university research and foster economic growth, it is important to understand how companies benefit from these collaborations, and to ensure that resulting academic discoveries are developed for the benefit of all stakeholders: companies, universities and public. Lock up of inventions, and censoring of academic publications, should be avoided if feasible. This case-study analysis of interviews with 90 companies in Canada, Japan, the UK and USA assesses the scope of this challenge and suggests possible resolutions. The participating companies were asked to describe an important interaction with universities, and most described collaborative research. The most frequently cited tensions concerned intellectual property management and publication freedom. IP disagreements were most frequent in the context of narrowly-focused collaborations with American universities. However, in the case of exploratory research, companies accepted the IP management practices of US universities. It might make sense to let companies have an automatic exclusive license to IP from narrowly defined collaborations, but to encourage universities to manage inventions from exploratory collaborations to ensure development incentives. Although Canada, the UK and US have strong publication freedom guarantees, tensions over this issue arose frequently in focused collaborations, though were rare in exploratory collaborations. The UK Lambert Agreements give sponsors the option to control publications in return for paying the full economic cost of a project. This may offer a model for the other three countries. Uniquely among the four countries, Japan enables companies to control exclusively most collaborative inventions and to censor academic publications. Despite this high degree of control, the interviews suggest many companies do not develop university discoveries to their full potential. The steps suggested above may rebalance the

  20. Industry-University Collaborations in Canada, Japan, the UK and USA – With Emphasis on Publication Freedom and Managing the Intellectual Property Lock-Up Problem

    PubMed Central

    Kneller, Robert; Mongeon, Marcel; Cope, Jeff; Garner, Cathy; Ternouth, Philip

    2014-01-01

    As industry-university collaborations are promoted to commercialize university research and foster economic growth, it is important to understand how companies benefit from these collaborations, and to ensure that resulting academic discoveries are developed for the benefit of all stakeholders: companies, universities and public. Lock up of inventions, and censoring of academic publications, should be avoided if feasible. This case-study analysis of interviews with 90 companies in Canada, Japan, the UK and USA assesses the scope of this challenge and suggests possible resolutions. The participating companies were asked to describe an important interaction with universities, and most described collaborative research. The most frequently cited tensions concerned intellectual property management and publication freedom. IP disagreements were most frequent in the context of narrowly-focused collaborations with American universities. However, in the case of exploratory research, companies accepted the IP management practices of US universities. It might make sense to let companies have an automatic exclusive license to IP from narrowly defined collaborations, but to encourage universities to manage inventions from exploratory collaborations to ensure development incentives. Although Canada, the UK and US have strong publication freedom guarantees, tensions over this issue arose frequently in focused collaborations, though were rare in exploratory collaborations. The UK Lambert Agreements give sponsors the option to control publications in return for paying the full economic cost of a project. This may offer a model for the other three countries. Uniquely among the four countries, Japan enables companies to control exclusively most collaborative inventions and to censor academic publications. Despite this high degree of control, the interviews suggest many companies do not develop university discoveries to their full potential. The steps suggested above may rebalance the

  1. Intellectual property rights, standards and data exchange in systems biology: Reflections from the IP Expert Meeting at the University of Luxembourg, 8-9 October 2015, ERASysAPP - ERA-Net for Systems Biology Applications.

    PubMed

    van Zimmeren, Esther; Rutz, Berthold; Minssen, Timo

    2016-12-01

    Intellectual property rights (IPRs) have become a key concern for researchers and industry in basically all high-tech sectors. IPRs regularly figure prominently in scientific journals and at scientific conferences and lead to dedicated workshops to increase the awareness and "IPR savviness" of scientists. In 2015, Biotechnology Journal published a report from an expert meeting on "Synthetic Biology & Intellectual Property Rights" organized by the Danish Agency for Science, Technology and Innovation sponsored by the European Research Area Network (ERA-Net) in Synthetic Biology (ERASynBio), in which we provided a number of recommendations for a variety of stakeholders [1]. The current article offers some deeper reflections about the interface between IPRs, standards and data exchange in systems biology (SysBio) resulting from an Expert Meeting funded by another ERA-Net, ERASysAPP. The meeting brought together experts and stakeholders (e.g. scientists, company representatives, officials from public funding organizations) in SysBio from different European countries. Despite the different profiles of the stakeholders at the meeting and the variety of interests, many concerns and opinions were shared. In case particular views were expressed by a specific type of stakeholder, this will be explicitly mentioned in the text. In this article, we explore a number of particularly relevant issues that were discussed at the meeting and offer some recommendations. SysBio involves the study of biological systems at a so-called systems level. This is not a new concept in the life sciences - many former approaches in physiology, enzymology and other scientific disciplines have already taken a systemic view of selected biological subjects. Yet, SysBio has gained strong interest within the past 10 to 15 years. One predominant reason and a critical prerequisite for this success story being that the relevant scientific methodologies and research tools have become far more powerful and

  2. Scholars, Intellectuals, and Bricoleurs

    ERIC Educational Resources Information Center

    Papson, Stephen

    2014-01-01

    This essay explores three orientations to knowledge: the scholar, the intellectual, and the bricoleur. It argues that although the scholar and the intellectual are tied closely to the Liberal Arts and Humanities and dominate academic public relations discourse, both students and faculty increasingly use the practice of bricolage to gather and…

  3. Cue properties change timing strategies in group movement synchronisation

    PubMed Central

    Honisch, Juliane J.; Elliott, Mark T.; Jacoby, Nori; Wing, Alan M.

    2016-01-01

    To maintain synchrony in group activities, each individual within the group must continuously correct their movements to remain in time with the temporal cues available. Cues might originate from one or more members of the group. Current research suggests that when synchronising movements, individuals optimise their performance in terms of minimising variability of timing errors (asynchronies) between external cues and their own movements. However, the cost of this is an increase in the timing variability of their own movements. Here we investigate whether an individual’s timing strategy changes according to the task, in a group scenario. To investigate this, we employed a novel paradigm that positioned six individuals to form two chains with common origin and termination on the circumference of a circle. We found that participants with access to timing cues from only one other member used a strategy to minimise their asynchrony variance. In contrast, the participant at the common termination of the two chains, who was required to integrate timing cues from two members, used a strategy that minimised movement variability. We conclude that humans are able to flexibly switch timekeeping strategies to maintain task demands and thus optimise the temporal performance of their movements. PMID:26781066

  4. Psychometric Properties of the AIR Self-Determination Scale: The Chinese Version (AIR SDS-C) for Chinese People with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Wong, P. K. S.; Wong, D. F. K.; Zhuang, X. Y.; Liu, Y.

    2017-01-01

    Background: The construct of self-determination has received considerable attention in the international field of intellectual disabilities (ID). Recently, there has been a rapid development of this construct in Chinese societies including Hong Kong. However, there is no locally validated instrument to measure self-determination in people with ID.…

  5. Intellectual Property Protection for Software

    DTIC Science & Technology

    1989-07-01

    taken from Coca - Cola Co. v. Snow Crest Beverages, Inc., 64 the employer’s program. F. Supp. 980 (D. Mass. 1946). Roth Trademark case discussing...that is, suggestive of person or firm that does not make the goods some quality or ingredient of the product) or services being certified. Use of the

  6. Falls prevention in persons with intellectual disabilities: development, implementation, and process evaluation of a tailored multifactorial fall risk assessment and intervention strategy.

    PubMed

    Smulders, Ellen; Enkelaar, Lotte; Schoon, Yvonne; Geurts, Alexander C; van Schrojenstein Lantman-de Valk, Henny; Weerdesteyn, Vivian

    2013-09-01

    In the general elderly population, multifactorial screening of fall risks has been shown to be effective. Although persons with intellectual disabilities (ID) fall more often, there appears to be no targeted screening for them. The aim of this study was to develop, implement, and evaluate a falls clinic for persons with ID. Based on guidelines, literature, and expert meetings, a falls clinic for persons with ID was developed. In total, 26 persons with ID and a fall history participated in the study. Process evaluation was conducted with evaluation forms and focus groups. Fifty interventions (0-8 per person) were prescribed. The (para)medical experts, clients, and caregivers described the falls clinic as useful. Advice for improvement included minor changes to clinic content. Logistics were the largest challenge for the falls clinic, for example organizing meetings, completing questionnaires prior to meetings, and ensuring that a personal caregiver accompanied the person with ID. Furthermore, the need for a screening tool to determine whether a person would benefit from the falls clinic was reported. In conclusion, the falls clinic for persons with ID was considered feasible and useful. Some minor content changes are necessary and there is a need for a screening tool. However, logistics concerning the falls clinic need improvement. More attention and time for multifactorial and multidisciplinary treatment of persons with ID is necessary. Implementation on a larger scale would also make it possible to investigate the effectiveness of the falls clinic with regard to the prevention of falls in this population.

  7. Interaction patterns between children and their teachers when using a specific multimedia and communication strategy: observations from children with autism and mixed intellectual disabilities.

    PubMed

    Tjus, T; Heimann, M; Nelson, K E

    2001-06-01

    This study reports on observed interaction patterns between 20 children with autism and mixed intellectual disabilities (mean chronological age = 11:4 years; language age = 4:7 years) and their nine teachers working with a specially developed multimedia program aiming to increase literacy skills. An increase in verbal expression was found over time for the total group. Children with autism also showed increased enjoyment and willingness to seek help from their teachers. Teachers for both diagnostic groups reduced their instructions on how to handle the computer during the program but the decrease was greater in the teachers for children with autism. When the total group of children was subdivided according to language age (high versus low), it appears that those with a low language age showed an increase in verbal expressiveness from start to end of training. Those with a high language age showed increased enjoyment. It is concluded that more detailed studies of the interaction patterns between teachers and children are needed, and these should be related to children's language level as well as to diagnostic group.

  8. Addressing legal and political barriers to global pharmaceutical access: options for remedying the impact of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) and the imposition of TRIPS-plus standards.

    PubMed

    Cohen-Kohler, Jillian Clare; Forman, Lisa; Lipkus, Nathaniel

    2008-07-01

    Despite myriad programs aimed at increasing access to essential medicines in the developing world, the global drug gap persists. This paper focuses on the major legal and political constraints preventing implementation of coordinated global policy solutions - particularly, the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) and bilateral and regional free trade agreements. We argue that several policy and research routes should be taken to mitigate the restrictive impact of TRIPS and TRIPS-plus rules, including greater use of TRIPS flexibilities, advancement of human rights, and an ethical framework for essential medicines distribution, and a broader campaign that debates the legitimacy of TRIPS and TRIPS-plus standards themselves.

  9. Influence Of The Laser Cladding Strategies On The Mechanical Properties Of Inconel 718

    SciTech Connect

    Lamikiz, A.; Tabernero, I.; Ukar, E.; Lopez de Lacalle, L. N.

    2011-01-17

    This work presents different experimental results of the mechanical properties of Inconel registered 718 test parts built-up by laser cladding. Recently, turbine manufacturers for aeronautical sector have presented high interest on laser cladding processes. This process allows building fully functional structures on superalloys, such as Inconel registered 718, with high flexibility on complex shapes. However, there is limited data on mechanical properties of the laser cladding structures. Moreover, the available data do not include the influence of process parameters and laser cladding strategies. Therefore, a complete study of the influence of the laser cladding parameters and mainly, the variation of the tensile strength with the laser cladding strategy is presented. The results show that there is a high directionality of mechanical properties, depending on the strategies of laser cladding process. In other words, the test parts show a fiber -like structure that should be considered on the laser cladding strategy selection.

  10. Influence Of The Laser Cladding Strategies On The Mechanical Properties Of Inconel 718

    NASA Astrophysics Data System (ADS)

    Lamikiz, A.; Tabernero, I.; Ukar, E.; López de Lacalle, L. N.; Delgado, J.

    2011-01-01

    This work presents different experimental results of the mechanical properties of Inconel® 718 test parts built-up by laser cladding. Recently, turbine manufacturers for aeronautical sector have presented high interest on laser cladding processes. This process allows building fully functional structures on superalloys, such as Inconel® 718, with high flexibility on complex shapes. However, there is limited data on mechanical properties of the laser cladding structures. Moreover, the available data do not include the influence of process parameters and laser cladding strategies. Therefore, a complete study of the influence of the laser cladding parameters and mainly, the variation of the tensile strength with the laser cladding strategy is presented. The results show that there is a high directionality of mechanical properties, depending on the strategies of laser cladding process. In other words, the test parts show a fiber -like structure that should be considered on the laser cladding strategy selection.

  11. Machine learning strategies for systems with invariance properties

    NASA Astrophysics Data System (ADS)

    Ling, Julia; Jones, Reese; Templeton, Jeremy

    2016-08-01

    In many scientific fields, empirical models are employed to facilitate computational simulations of engineering systems. For example, in fluid mechanics, empirical Reynolds stress closures enable computationally-efficient Reynolds Averaged Navier Stokes simulations. Likewise, in solid mechanics, constitutive relations between the stress and strain in a material are required in deformation analysis. Traditional methods for developing and tuning empirical models usually combine physical intuition with simple regression techniques on limited data sets. The rise of high performance computing has led to a growing availability of high fidelity simulation data. These data open up the possibility of using machine learning algorithms, such as random forests or neural networks, to develop more accurate and general empirical models. A key question when using data-driven algorithms to develop these empirical models is how domain knowledge should be incorporated into the machine learning process. This paper will specifically address physical systems that possess symmetry or invariance properties. Two different methods for teaching a machine learning model an invariance property are compared. In the first method, a basis of invariant inputs is constructed, and the machine learning model is trained upon this basis, thereby embedding the invariance into the model. In the second method, the algorithm is trained on multiple transformations of the raw input data until the model learns invariance to that transformation. Results are discussed for two case studies: one in turbulence modeling and one in crystal elasticity. It is shown that in both cases embedding the invariance property into the input features yields higher performance at significantly reduced computational training costs.

  12. Machine learning strategies for systems with invariance properties

    SciTech Connect

    Ling, Julia; Jones, Reese E.; Templeton, Jeremy Alan

    2016-05-06

    Here, in many scientific fields, empirical models are employed to facilitate computational simulations of engineering systems. For example, in fluid mechanics, empirical Reynolds stress closures enable computationally-efficient Reynolds-Averaged Navier-Stokes simulations. Likewise, in solid mechanics, constitutive relations between the stress and strain in a material are required in deformation analysis. Traditional methods for developing and tuning empirical models usually combine physical intuition with simple regression techniques on limited data sets. The rise of high-performance computing has led to a growing availability of high-fidelity simulation data, which open up the possibility of using machine learning algorithms, such as random forests or neural networks, to develop more accurate and general empirical models. A key question when using data-driven algorithms to develop these models is how domain knowledge should be incorporated into the machine learning process. This paper will specifically address physical systems that possess symmetry or invariance properties. Two different methods for teaching a machine learning model an invariance property are compared. In the first , a basis of invariant inputs is constructed, and the machine learning model is trained upon this basis, thereby embedding the invariance into the model. In the second method, the algorithm is trained on multiple transformations of the raw input data until the model learns invariance to that transformation. Results are discussed for two case studies: one in turbulence modeling and one in crystal elasticity. It is shown that in both cases embedding the invariance property into the input features yields higher performance with significantly reduced computational training costs.

  13. Machine learning strategies for systems with invariance properties

    DOE PAGES

    Ling, Julia; Jones, Reese E.; Templeton, Jeremy Alan

    2016-05-06

    Here, in many scientific fields, empirical models are employed to facilitate computational simulations of engineering systems. For example, in fluid mechanics, empirical Reynolds stress closures enable computationally-efficient Reynolds-Averaged Navier-Stokes simulations. Likewise, in solid mechanics, constitutive relations between the stress and strain in a material are required in deformation analysis. Traditional methods for developing and tuning empirical models usually combine physical intuition with simple regression techniques on limited data sets. The rise of high-performance computing has led to a growing availability of high-fidelity simulation data, which open up the possibility of using machine learning algorithms, such as random forests or neuralmore » networks, to develop more accurate and general empirical models. A key question when using data-driven algorithms to develop these models is how domain knowledge should be incorporated into the machine learning process. This paper will specifically address physical systems that possess symmetry or invariance properties. Two different methods for teaching a machine learning model an invariance property are compared. In the first , a basis of invariant inputs is constructed, and the machine learning model is trained upon this basis, thereby embedding the invariance into the model. In the second method, the algorithm is trained on multiple transformations of the raw input data until the model learns invariance to that transformation. Results are discussed for two case studies: one in turbulence modeling and one in crystal elasticity. It is shown that in both cases embedding the invariance property into the input features yields higher performance with significantly reduced computational training costs.« less

  14. Life Satisfaction in Persons with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Lucas-Carrasco, Ramona; Salvador-Carulla, Luis

    2012-01-01

    We appraised life satisfaction using the Satisfaction with Life Scale (SWLS), and analysed its psychometric properties in persons with intellectual disability (ID). Ninety-nine persons with ID from four services in Spain participated. A battery of subjective assessments was used, including the SWLS, a Quality of Life measure (WHOQOL-BREF), and…

  15. Exome Sequencing and the Genetics of Intellectual Disability

    PubMed Central

    Topper, Scott; Ober, Carole; Das, Soma

    2014-01-01

    Exome sequencing has greatly impacted the speed at which new disease genes are identified. In the last year alone, six studies have used exome sequencing to identify new genes involved in intellectual disability, a genetically heterogeneous condition affecting 1–3% of the population. These studies encompass the full gamut of modes of inheritance and phenotypic presentation, including syndromic and non-syndromic conditions, sporadic and familial cases, and dominant and recessive inheritance patterns. Because different disease presentations require different approaches to gene discovery, studies of intellectual disability provide a nearly comprehensive showcase of strategies for exome-driven gene discovery. Despite these successes, the etiology of ~60% of cases of intellectual disability remains unknown. The application of exome sequencing to the clinical diagnosis of intellectual disability in the near future will ultimately reduce the number of idiopathic cases and provide a rich source of sequence variation for the identification of new intellectual disability genes. PMID:21627642

  16. [A cold/heat property classification strategy based on bio-effects of herbal medicines].

    PubMed

    Jiang, Miao; Lv, Ai-Ping

    2014-06-01

    The property theory of Chinese herbal medicine (CHM) is regarded as the core and basic of Chinese medical theory, however, the underlying mechanism of the properties in CHMs remains unclear, which impedes a barrier for the modernization of Chinese herbal medicine. The properties of CHM are often categorized into cold and heat according to the theory of Chinese medicine, which are essential to guide the clinical application of CHMs. There is an urgent demand to build a cold/heat property classification model to facilitate the property theory of Chinese herbal medicine, as well as to clarify the controversial properties of some herbs. Based on previous studies on the cold/heat properties of CHM, in this paper, we described a novel strategy on building a cold/heat property classification model based on herbal bio-effect. The interdisciplinary cooperation of systems biology, pharmacological network, and pattern recognition technique might lighten the study on cold/heat property theory, provide a scientific model for determination the cold/heat property of herbal medicines, and a new strategy for expanding the Chinese herbal medicine resources as well.

  17. An Intellectual Freedom Theme Issue.

    ERIC Educational Resources Information Center

    Bolner, Myrtle Smith, Ed.

    1986-01-01

    Prepared by an intellectual freedom committee, this issue is intended to aid librarians in thinking about intellectual freedom when confronted with the current creationism controversy. A manual containing documents and resources on intellectual freedom, a bibliography of pro- and anti-creationism materials, and results of a censorship survey are…

  18. Intellectual Freedom: 2000 and Beyond.

    ERIC Educational Resources Information Center

    Holtze, Terri L.; Rader, Hannelore B.

    2000-01-01

    Focuses on intellectual freedom, discussing the role of libraries, the Berlin Wall and banned books as attempts to restrict intellectual freedom, and controversies surrounding filtering software. Contains an annotated bibliography of intellectual freedom resources, presented in five categories: general; government and legal issues; access and…

  19. A Canadian Investigation of the Psychometric Properties of the Student Motivation and Learning Strategies Inventory

    ERIC Educational Resources Information Center

    Janzen, Troy; Cormier, Damien C.; Hetherington, Jay; Mrazik, Martin; Mousavi, Amin

    2015-01-01

    The psychometric properties of the Student Motivation and Learning Strategies Inventory (SMALSI) were examined using a sample of 404 Grade 6 students from an urban Canadian school system. Students completed the SMALSI and school factors included final school grades, attendance records, and language arts, mathematics, science, and social studies…

  20. Carpentry Is Intellectual Work

    ERIC Educational Resources Information Center

    Sherman, Robert R.

    2014-01-01

    This article argues that carpentry is as much an intellectual as a physical activity. Terms are defined, the problem is outlined, examples are given, and some general conclusions are drawn for education. Some sketches are provided for graphic illustration of the examples. The interpretation in effect is pragmatic and cites Dewey on occasion to…

  1. Perspectives: Intellectual Risk Management

    ERIC Educational Resources Information Center

    Hall, James C.

    2013-01-01

    Ask a college administrator about students and risk management, and you're likely to get a quick and agitated speech about alcohol consumption and bad behavior or a meditation on mental health and campus safety. But in colleges and universities, we manage intellectual risk-taking too. Bring that up, and you'll probably get little out of that same…

  2. Perfecting Intellectual Community.

    ERIC Educational Resources Information Center

    Wegener, Charles

    1990-01-01

    Liberal arts faculty are ill equipped to teach their disciplines; they are equipped to transmit the latest research results as they define the discipline. Students are not well prepared to respond; they have not been encouraged to enter into others' thinking. Under these conditions, the prospects for intellectual community are not good. (MSE)

  3. Framing Evolution Discussion Intellectually

    ERIC Educational Resources Information Center

    Oliveira, Alandeom W.; Cook, Kristin; Buck, Gayle A.

    2011-01-01

    This study examines how a first-year biology teacher facilitates a series of whole-class discussions about evolution during the implementation of a problem-based unit. A communicative theoretical perspective is adopted wherein evolution discussions are viewed as social events that the teacher can frame intellectually (i.e., present or organize as…

  4. Intellectual Competence and Aggression.

    ERIC Educational Resources Information Center

    Huesmann, L. Rowell; Yarmel, Patty Warnick

    Using data from a broader longitudinal study, this investigation explores within-subject and cross-generational stability of intellectual competence and the relationship of such stability to aggressive behavior. Data were gathered three times (when subjects' modal age was 8, 19, and 30 years). Initially, subjects included the entire population…

  5. Intellectual Disability and Homelessness

    ERIC Educational Resources Information Center

    Mercier, C.; Picard, S.

    2011-01-01

    Background: The association between poverty and intellectual disability (ID) has been well documented. However, little is known about persons with ID who face circumstances of extreme poverty, such as homelessness. This paper describes the situation of persons with ID who were or are homeless in Montreal and are currently receiving services from a…

  6. Cultivating Intellectual Safety in a Women and Leadership Course

    ERIC Educational Resources Information Center

    Shollen, S. Lynn

    2016-01-01

    This application brief provides pedagogical strategies for teaching and learning about women and leadership as a potentially sensitive subject, with emphasis on creating an intellectually safe learning environment. Findings from a study of students' expectations and experiences with a Women and Leadership course showed that the strategies affected…

  7. Mechanical properties of structural amorphous steels: Intrinsic correlations, conflicts, and optimizing strategies

    SciTech Connect

    Liu, Z. Q. Zhang, Z. F.

    2013-12-28

    Amorphous steels have demonstrated superior properties and great potentials for structural applications since their emergence, yet it still remains unclear about how and why their mechanical properties are correlated with other factors and how to achieve intended properties by designing their compositions. Here, the intrinsic interdependences among the mechanical, thermal, and elastic properties of various amorphous steels are systematically elucidated and a general trade-off relation is exposed between the strength and ductility/toughness. Encouragingly, a breakthrough is achievable that the strength and ductility/toughness can be simultaneously improved by tuning the compositions. The composition dependences of the properties and alloying effects are further analyzed thoroughly and interpreted from the fundamental plastic flow and atomic bonding characters. Most importantly, systematic strategies are outlined for optimizing the mechanical properties of the amorphous steels. The study may help establish the intrinsic correlations among the compositions, atomic structures, and properties of the amorphous steels, and provide useful guidance for their alloy design and property optimization. Thus, it is believed to have implications for the development and applications of the structural amorphous steels.

  8. Volatility measurement with directional change in Chinese stock market: Statistical property and investment strategy

    NASA Astrophysics Data System (ADS)

    Ma, Junjun; Xiong, Xiong; He, Feng; Zhang, Wei

    2017-04-01

    The stock price fluctuation is studied in this paper with intrinsic time perspective. The event, directional change (DC) or overshoot, are considered as time scale of price time series. With this directional change law, its corresponding statistical properties and parameter estimation is tested in Chinese stock market. Furthermore, a directional change trading strategy is proposed for invest in the market portfolio in Chinese stock market, and both in-sample and out-of-sample performance are compared among the different method of model parameter estimation. We conclude that DC method can capture important fluctuations in Chinese stock market and gain profit due to the statistical property that average upturn overshoot size is bigger than average downturn directional change size. The optimal parameter of DC method is not fixed and we obtained 1.8% annual excess return with this DC-based trading strategy.

  9. Multi-Scale Modeling, Design Strategies and Physical Properties of 2D Composite Sheets

    DTIC Science & Technology

    2015-01-15

    of Pennsylvania. The breakthrough results obtained are 1) prediction and subsequent experimental observation of strain induced changes in electronic...structure of TMD materials 2) Prediction and experimental observation of using defects in 2D materials to enhance charge storage capacity and 3...221 Philadelphia , PA 19104 -6205 4-Mar-2014 ABSTRACT Final Report: 9.4: Multi-scale modeling, design strategies and physical properties of 2D

  10. Preoperational Graphic Representation: From Intellectual Realism to Visual Realism in Draw a House-Tree Task.

    ERIC Educational Resources Information Center

    Kalyan-Masih, Violet

    In a pilot study of children's drawings of "a house with a tree behind it," Piagetian sequence (scribbling, fortuitous realism, failed realism, intellectual realism, and visual realism) was tentatively supported. Children's strategies in decentering from intellectual to visual realism were noted. The study reported in this paper was…

  11. Practitioners Who Work with Parents with Intellectual Disability: Stress, Coping and Training Needs

    ERIC Educational Resources Information Center

    Clayton, Olivia; Chester, Andrea; Mildon, Robyn; Matthews, Jan

    2008-01-01

    Background: Challenges for practitioners who work with parents with intellectual disability arise from several sources. The purpose of the current study was to identify the stressors experienced by practitioners who work with parents with intellectual disability in Australia, investigate coping strategies and explore training needs so as to inform…

  12. Mathematical models use varying parameter strategies to represent paralyzed muscle force properties: a sensitivity analysis

    PubMed Central

    Frey Law, Laura A; Shields, Richard K

    2005-01-01

    Background Mathematical muscle models may be useful for the determination of appropriate musculoskeletal stresses that will safely maintain the integrity of muscle and bone following spinal cord injury. Several models have been proposed to represent paralyzed muscle, but there have not been any systematic comparisons of modelling approaches to better understand the relationships between model parameters and muscle contractile properties. This sensitivity analysis of simulated muscle forces using three currently available mathematical models provides insight into the differences in modelling strategies as well as any direct parameter associations with simulated muscle force properties. Methods Three mathematical muscle models were compared: a traditional linear model with 3 parameters and two contemporary nonlinear models each with 6 parameters. Simulated muscle forces were calculated for two stimulation patterns (constant frequency and initial doublet trains) at three frequencies (5, 10, and 20 Hz). A sensitivity analysis of each model was performed by altering a single parameter through a range of 8 values, while the remaining parameters were kept at baseline values. Specific simulated force characteristics were determined for each stimulation pattern and each parameter increment. Significant parameter influences for each simulated force property were determined using ANOVA and Tukey's follow-up tests (α ≤ 0.05), and compared to previously reported parameter definitions. Results Each of the 3 linear model's parameters most clearly influence either simulated force magnitude or speed properties, consistent with previous parameter definitions. The nonlinear models' parameters displayed greater redundancy between force magnitude and speed properties. Further, previous parameter definitions for one of the nonlinear models were consistently supported, while the other was only partially supported by this analysis. Conclusion These three mathematical models use

  13. Influence of post-treatment strategies on the properties of activated chars from broiler manure.

    PubMed

    Lima, Isabel M; Boykin, Debbie L; Thomas Klasson, K; Uchimiya, Minori

    2014-01-01

    There are a myriad of carbonaceous precursors that can be used advantageously to produce activated carbons or chars, due to their low cost, availability and intrinsic properties. Because of the nature of the raw material, production of granular activated chars from broiler manure results in a significant ash fraction. This study was conducted to determine the influence of several pre- and post-treatment strategies in various physicochemical and adsorptive properties of the resulting activated chars. Pelletized samples of broiler litter and cake were pyrolyzed at 700 °C for 1h followed by a 45 min steam activation at 800 °C at different water flow rates from 1 to 5 mL min(-1). For each activation strategy, samples were either water-rinsed or acid-washed and rinsed or used as is (no acid wash/rinse). Activated char's physicochemical and adsorptive properties towards copper ions were selectively affected by both pre- and post-treatments. Percent ash reduction after either rinsing or acid washing ranged from 1.1 to 15.1% but washed activated chars were still alkaline with pH ranging from 8.4 to 9.1. Acid washing or water rinsing had no significant effect in the ability of the activated char to adsorb copper ions, however it significantly affected surface area, pH, ash content and carbon content. Instead, manure type (litter versus cake) and the activation water flow rate were determining factors in copper ion adsorption which ranged from 38 mg g(-1) to 104 mg g(-1) of activated char. Moreover, strong positive correlations were found between copper uptake and concentration of certain elements in the activated char such as phosphorous, sulfur, calcium and sodium. Rinsing could suffice as a post treatment strategy for ash reduction since no significant differences in the carbon properties were observed between rinsed and acid wash treatments.

  14. Cellular and circuit properties supporting different sensory coding strategies in electric fish and other systems.

    PubMed

    Marsat, Gary; Longtin, André; Maler, Leonard

    2012-08-01

    Neural codes often seem tailored to the type of information they must carry. Here we contrast the encoding strategies for two different communication signals in electric fish and describe the underlying cellular and network properties that implement them. We compare an aggressive signal that needs to be quickly detected, to a courtship signal whose quality needs to be evaluated. The aggressive signal is encoded by synchronized bursts and a predictive feedback input is crucial in separating background noise from the communication signal. The courtship signal is accurately encoded through a heterogenous population response allowing the discrimination of signal differences. Most importantly we show that the same strategies are used in other systems arguing that they evolved similar solutions because they faced similar tasks.

  15. Intellectual Capital: Comparison and Contrast.

    ERIC Educational Resources Information Center

    Madsen, Susan R.

    2001-01-01

    Suggests that one of the most important keys for improving individual and organizational performance is in developing and strengthening intellectual capital (IC) and explores the similarities and differences between the concepts of intellectual capital, human capital, and knowledge management. Presents four IC characteristics and addresses the…

  16. Intellectual Work and Knowledge Production

    ERIC Educational Resources Information Center

    Gunter, Helen M.

    2012-01-01

    The university as a site of public intellectuals and intellectual work is facing challenge. Historically this has happened and continues apace through the inter-relationship of a number of trends: first, the entry of disciplines into bureaucratic specialisation, where status is through a named school, disciplinary paradigms and networks, journals…

  17. Intellectual Freedom Manual. Eighth Edition

    ERIC Educational Resources Information Center

    ALA Editions, 2010

    2010-01-01

    Updated for the first time since 2005, this indispensable volume includes revised interpretations of the Library Bill of Rights along with key intellectual freedom guidelines and policies, including: (1) A new chapter, "Interactivity and the Internet," and other fresh material on intellectual freedom and privacy in online social…

  18. Global Academe: Engaging Intellectual Discourse

    ERIC Educational Resources Information Center

    Nagy-Zekmi, Silvia, Ed.; Hollis, Karyn, Ed.

    2012-01-01

    The representation of the economic, political, cultural and, more importantly, global interrelations between agents involved in the process of intellectual activity is at the core of the inquiry in this volume that scrutinizes a distinct transformation occurring in the modalities of intellectual production also detectable in the changing role of…

  19. Anthony Crosland: Intellectual and Politician

    ERIC Educational Resources Information Center

    Kogan, Maurice

    2006-01-01

    Anthony Crosland was the most formative of education ministers in the 1960s whose contribution promoted intellectual activity within the policy discourse. He retains an iconic status for that reason. He provided the intellectual foundations of "revisionism" which emancipated the Labour Party from belief in nationalisation as the way to…

  20. The Awakening of Intellectual Virtue.

    ERIC Educational Resources Information Center

    Stutz, Cathleen K.; Tauer, Susan M.

    2000-01-01

    Responds to the assumption that it is too late to teach virtue in college, noting that Aristotle considered intellectual virtue essential to the cultivation of excellence. Asserts that university education ought to embrace the cultivation of intellectual virtue in students, proposing that by helping students see the pursuit of knowledge as a…

  1. Students with Intellectual Disabilities Going to College? Absolutely!

    ERIC Educational Resources Information Center

    Kleinert, Harold L.; Jones, Melissa M.; Sheppard-Jones, Kathleen; Harp, Beverly; Harrison, Elizabeth M.

    2012-01-01

    In this article we describe the new opportunities for postsecondary education available to students with intellectual disabilities (ID) through the Higher Education Opportunities Act of 2008. We also identify the importance of these opportunities for students with ID, and key strategies for ensuring that their college experience is an important…

  2. Another Look at Student Writing and Stages of Intellectual Development.

    ERIC Educational Resources Information Center

    Mullin, Anne E.

    1998-01-01

    States that theories of intellectual development offer writing teachers productive ways to analyze student writing; help students develop strategies for improving their writing processes; and consider the implications of writing assignments. Finds that frameworks posited by Jean Piaget and by others contribute useful ways of understanding why…

  3. Enabling Integration in Sports for Adolescents with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Grandisson, Marie; Tetreault, Sylvie; Freeman, Andrew R.

    2012-01-01

    Background: Promoting the health and social participation of adolescents with intellectual disability is important as they are particularly vulnerable to encountering difficulties in those areas. Integration of these individuals in integrated sports is one strategy to address this issue. Methods: The main objective of this study was to gain a…

  4. ACCESS! Teaching Writing Skills to Students with Intellectual Disability

    ERIC Educational Resources Information Center

    Cannella-Malone, Helen I.; Konrad, Moira; Pennington, Robert C.

    2015-01-01

    The purpose of this article is to provide teachers with tools that they can use to teach written expression to school-age students with intellectual disabilities. These tools are presented around the mnemonic ACCESS: accommodations and assistive technologies, concrete topics, critical skills, explicit instruction, strategy instruction, systematic…

  5. Modifying the "Positive Parenting Program" for Parents with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Glazemakers, I.; Deboutte, D.

    2013-01-01

    Background: Many parents with intellectual disabilities (ID) want and/or need professional guidance and support to learn skills and strategies to prevent and manage child behaviour problems. However, the available support is rarely suitable, and suitable support is rarely available. The aim of this study was to determine whether a popular…

  6. Non-verbal communication between nurses and people with an intellectual disability: a review of the literature.

    PubMed

    Martin, Anne-Marie; O'Connor-Fenelon, Maureen; Lyons, Rosemary

    2010-12-01

    This article critically synthesizes current literature regarding communication between nurses and people with an intellectual disability who communicate non-verbally. The unique context of communication between the intellectual disability nurse and people with intellectual disability and the review aims and strategies are outlined. Communication as a concept is explored in depth. Communication between the intellectual disability nurse and the person with an intellectual disability is then comprehensively examined in light of existing literature. Issues including knowledge of the person with intellectual disability, mismatch of communication ability, and knowledge of communication arose as predominant themes. A critical review of the importance of communication in nursing practice follows. The paucity of literature relating to intellectual disability nursing and non-verbal communication clearly indicates a need for research.

  7. Polydopamine and eumelanin: from structure-property relationships to a unified tailoring strategy.

    PubMed

    d'Ischia, Marco; Napolitano, Alessandra; Ball, Vincent; Chen, Chun-Teh; Buehler, Markus J

    2014-12-16

    the bottom up, and to design and optimize materials to achieve desired properties is illustrated. The impact of synthetic conditions on melanin structure and physicochemical properties is systematically discussed for the first time. Rational tailoring strategies directed to critical control points of the synthetic pathways, such as dopaquinone, DAquinone, and dopachrome, are then proposed, with a view to translating basic chemical knowledge into practical guidelines for material manipulation and tailoring. This key concept is exemplified by the recent demonstration that varying DA concentration, or using Tris instead of phosphate as the buffer, results in PDA materials with quite different structural properties. Realizing that PDA and synthetic eumelanins belong to the same family of functional materials may foster unprecedented synergisms between research fields that have so far been apart in the pursuit of tailorable and marketable materials for energy, biomedical, and environmental applications.

  8. Non-verbal communication between Registered Nurses Intellectual Disability and people with an intellectual disability: an exploratory study of the nurse's experiences. Part 2.

    PubMed

    Martin, Anne-Marie; Connor-Fenelon, Maureen O'; Lyons, Rosemary

    2012-06-01

    This is the second of two articles presenting the findings of a qualitative study which explored the experiences of Registered Nurses Intellectual Disability (RNIDs) of communicating with people with an intellectual disability who communicate non-verbally. While Part 1 outlined the study background, context and methodology along with the overarching, multi-dimensional category of 'familiarity/knowing the person', the current article critically discusses the themes and subthemes encapsulated in this category. Each theme is considered in the light of current policies, strategies and philosophies shaping the provision of services to people with an intellectual disability in Ireland. The results suggest that the RNID is ideally located and key to supporting the implementation of these policies and strategies due to their highly developed and proficient skill set as well as experience of communicating with people with an intellectual disability who communicate non-verbally.

  9. Children with an Intellectual Disability

    MedlinePlus

    ... only on the basis of below-normal intelligence (IQ), and that persons with intellectual disabilities are unable ... the person has to have both significantly low IQ and considerable problems in everyday functioning. Most children ...

  10. Intellectual and Developmental Disabilities

    MedlinePlus

    ... Process Info about applying, review & approval of a research grant Grant Policies & Funding Strategies Policies on human subjects, data sharing, large grants & other topics Funding Opportunities & Mechanisms ...

  11. Patterns in American Intellectual Frontiers

    DTIC Science & Technology

    1990-08-01

    in some new framework.’ The ascendant phase or leading edge of each intellectual frontier is populated by enthusiastic visionaries who eagerly...1823-1893) who expressed the intellectual idea of the land frontier in their writings for those who stayed home, while the art of Frederick Remington...34Daddy Warbucks" of the comic strip, "Little Orphan Annie," was initially introduced derisively as a symbol of the role of the industrial barons in

  12. Health promotion and intellectual disability: listening to men.

    PubMed

    Bollard, Martin

    2017-01-01

    Taking responsibility for your own health has been a central tenet of public health policy internationally for a number of decades. Governments in the UK and internationally continue to promote a plethora of health promotion strategies, encouraging individuals and communities to adopt healthy lifestyle choices. Although it is widely recognised that men are not as proactive in seeking out medical help or taking on health promotion advice as women, limited gender-sensitive research exists in the field of intellectual disability. Despite many health promotion policy and practice strategies targeted at this population, little research exists exploring whether men with intellectual disability acknowledge health promotion advice. The study aimed to explore how men with mild-to-moderate intellectual disability understood and perceived their health and what health promotion messages they acted upon. The study was based on a participatory approach which enabled 11 men with intellectual disability to contribute as steering group members and as participants through one-to-one interviews. Data were collected between September 2011 and July 2012. Thematic analysis was undertaken. The participants demonstrated a capacity to understand their own health. This was inclusive of a concern about associating being obese with being unhealthy. The participants reported good relationships with their general practitioners (GPs) and felt valued, in particular when the GP was prepared to offer specific intellectual disability and health promotion advice. More gendered research inclusive of the views of this male population is required and the study reiterates the importance of promoting the health of men and women with intellectual disability.

  13. Microstructures and Properties of Medium Manganese Sheet Steels - Strategies and Opportunities

    SciTech Connect

    Rana, Radhakanta

    2015-10-06

    Medium manganese steels, with 3 to 10 wt pct Mn, have been shown to be capable of being thermally-processed to produce sheet products with a variety of strength-ductility combinations and thus are receiving considerable attention as candidates for 3rd generation advanced high strength steels (3GAHSS). The steels typically contain refined microstructures with characteristic microstructural dimensions of 1 to 2 µm and consist of significant amounts of retained austenite in a fine grained ferritic matrix. Strategies for development of medium manganese steels are reviewed and results of recent property predictions based on composite modeling are presented. The importance of controlling austenite stability is illustrated with data on medium Mn (7 and 10 wt pct.), low carbon (0.1 and 0.15 wt pct) steels. Important forming variables (strain, strain rate, and temperature) are discussed, along with a consideration of yield point elongation, present in many medium Mn steels.

  14. Route learning and shortcut performance in adults with intellectual disability: a study with virtual environments.

    PubMed

    Mengue-Topio, Hursula; Courbois, Yannick; Farran, Emily K; Sockeel, Pascal

    2011-01-01

    The ability to learn routes though a virtual environment (VE) and to make a novel shortcut between two locations was assessed in 18 adults with intellectual disability and 18 adults without intellectual disability matched on chronological age. Participants explored two routes (A ⇔ B and A ⇔ C) until they reached a learning criterion. Then, they were placed at B and were asked to find the shortest way to C (B ⇔ C, five trials). Participants in both groups could learn the routes, but most of the participants with intellectual disability could not find the shortest route between B and C. However, the results also revealed important individual differences within the intellectual disability group, with some participants exhibiting more efficient wayfinding behaviour than others. Individuals with intellectual disability may differ in the kind of spatial knowledge they extract from the environment and/or in the strategy they use to learn routes.

  15. Vadose-zone monitoring strategy to evaluate desalted groundwater effects on hydraulic properties

    NASA Astrophysics Data System (ADS)

    Valdes-Abellan, J.; Candela, L.; Jiménez-Martínez, J.

    2012-04-01

    Desalinated brackish groundwater is becoming a new source of water supply to comply with growing water demands, especially in (semi) arid countries. Irrigation with desalinated or a blend of desalinated and ground/surface water, presents associated impacts on plants, soil and aquifer media. Mixed waters with different salinities can lead to the formation of unexpected chemical precipitates. The use of desalted groundwater for irrigation counts with potential drawbacks, among them: changes of hydraulic properties of soil-aquifer systems (e.g. hydraulic conductivity, porosity) as a consequence of mineral precipitation; root growth blockage and plant uptake of pollutants; as well as leaching of contaminants to groundwater. An experimental plot located at SE Spain, covered by grass and irrigated by sprinklers with a blend of desalted and groundwater from a brackish aquifer, has been monitored in order to characterize at field scale the possible impacts on soil hydraulic properties. The monitoring strategy to control water and heat flux includes traditional and more updated devices. The field instrumentation, vertically installed from the ground surface and spatially distributed, consisted of: ten tensiometers (Soilmoisture Equipment Corp, Goleta, CA, USA) at different depths (two per depth); and, two access tubes (fiber glass, 44mm diameter 2m length) for soil moisture measurements from TRIME-FM TDR probe (Imko GmbH, Ettlingen, Germany). Automatic logging is carried out from a trench located in the border of the experimental plot and it takes in: a set of five 5TE devices (Decagon Devices Inc, Pullman, WA, USA) vertically installed, which measure volumetric water content, electric conductivity and temperature; and additionally, a suction sensor at 0.6m depth. Finally, a periodic sampling of undisturbed soil cores (2m length) takes place for the purpose of imaging porosity changes from environmental scanning electron microscope (ESEM). First results about water and heat

  16. Vadose zone monitoring strategies to control water flux dynamics and changes in soil hydraulic properties.

    NASA Astrophysics Data System (ADS)

    Valdes-Abellan, Javier; Jiménez-Martínez, Joaquin; Candela, Lucila

    2013-04-01

    For monitoring the vadose zone, different strategies can be chosen, depending on the objectives and scale of observation. The effects of non-conventional water use on the vadose zone might produce impacts in porous media which could lead to changes in soil hydraulic properties, among others. Controlling these possible effects requires an accurate monitoring strategy that controls the volumetric water content, θ, and soil pressure, h, along the studied profile. According to the available literature, different monitoring systems have been carried out independently, however less attention has received comparative studies between different techniques. An experimental plot of 9x5 m2 was set with automatic and non-automatic sensors to control θ and h up to 1.5m depth. The non-automatic system consisted of ten Jet Fill tensiometers at 30, 45, 60, 90 and 120 cm (Soil Moisture®) and a polycarbonate access tube of 44 mm (i.d) for soil moisture measurements with a TRIME FM TDR portable probe (IMKO®). Vertical installation was carefully performed; measurements with this system were manual, twice a week for θ and three times per week for h. The automatic system composed of five 5TE sensors (Decagon Devices®) installed at 20, 40, 60, 90 and 120 cm for θ measurements and one MPS1 sensor (Decagon Devices®) at 60 cm depth for h. Installation took place laterally in a 40-50 cm length hole bored in a side of a trench that was excavated. All automatic sensors hourly recorded and stored in a data-logger. Boundary conditions were controlled with a volume-meter and with a meteorological station. ET was modelled with Penman-Monteith equation. Soil characterization include bulk density, gravimetric water content, grain size distribution, saturated hydraulic conductivity and soil water retention curves determined following laboratory standards. Soil mineralogy was determined by X-Ray difractometry. Unsaturated soil hydraulic parameters were model-fitted through SWRC-fit code and

  17. Large size superelastic SMA bars: heat treatment strategy, mechanical property and seismic application

    NASA Astrophysics Data System (ADS)

    Wang, Wei; Fang, Cheng; Liu, Jia

    2016-07-01

    This paper reports a comprehensive study on the mechanical performance of large size superelastic shape memory alloy (SMA) bars, with the main focus given to their potential applications for seismic-resistant connections. A series of practical issues, including heat treatment, mechanical property assessment, and connection design/evaluation, were discussed aiming to benefit both material and civil engineering communities. The study commenced with a detailed discussion on the heat treatment strategy for SMA bars and the resulting mechanical properties including strength/stiffness, self-centring ability, energy dissipation, and fractural resistance. It was observed that the mechanical performance of the bars were quite sensitive to both annealing temperature and duration, and size effect was also evident, resulting in different appropriate heat treatment procedures for the bars with varying diameters. The optimally heat-treated SMA bars were machined to the bolt form and were then used for two types of practical self-centring connections, namely, connection with all SMA bars and that with combined angles and SMA bars. Through conducting full-scale tests, both connections were shown to have stable and controllable hysteretic responses till 5% loading drift. Up to 3% drift, the self-centring performance was satisfactory for both connection types, but beyond that the presence of the angles could lead to accumulated residual rotation. Importantly, for both connections, the deformation was accommodated by the SMA bolts or angles, whereas no plastic deformation was observed at any other structural members. This confirmed the feasibility of using such connections for highly resilient structures where minimal repair work is required after earthquakes.

  18. Development of improved space sampling strategies for ocean chemical properties: Total carbon dioxide and dissolved nitrate

    NASA Technical Reports Server (NTRS)

    Goyet, Catherine; Davis, Daniel; Peltzer, Edward T.; Brewer, Peter G.

    1995-01-01

    Large-scale ocean observing programs such as the Joint Global Ocean Flux Study (JGOFS) and the World Ocean Circulation Experiment (WOCE) today, must face the problem of designing an adequate sampling strategy. For ocean chemical variables, the goals and observing technologies are quite different from ocean physical variables (temperature, salinity, pressure). We have recently acquired data on the ocean CO2 properties on WOCE cruises P16c and P17c that are sufficiently dense to test for sampling redundancy. We use linear and quadratic interpolation methods on the sampled field to investigate what is the minimum number of samples required to define the deep ocean total inorganic carbon (TCO2) field within the limits of experimental accuracy (+/- 4 micromol/kg). Within the limits of current measurements, these lines were oversampled in the deep ocean. Should the precision of the measurement be improved, then a denser sampling pattern may be desirable in the future. This approach rationalizes the efficient use of resources for field work and for estimating gridded (TCO2) fields needed to constrain geochemical models.

  19. A novel strategy to synthesize hierarchical, porous carbohydrate-derived carbon with tunable properties.

    PubMed

    Wang, Shiping; Liu, Ruihan; Han, Chuanlong; Wang, Jing; Li, Mingming; Yao, Jia; Li, Haoran; Wang, Yong

    2014-11-21

    Hydrothermal carbonization (HTC) of carbohydrate is an interesting candidate for the preparation of carbon materials, as it provides an easy, inexpensive and environmental friendly route. However, it is difficult to prepare porous carbon materials by a straight HTC process. Herein, the solubilising technology of micelles was introduced to direct the HTC of fructose by using an amphiphilic block copolymer, poly-(4-vinylpyridine)-block-poly-(ethylene glycol) (P4VP-PEG), as a structure-directing agent. By this strategy, hierarchical porous carbon materials with tunable properties were prepared. It was found that P4VP-PEG micelles could solubilize fructose and confine the formation of primary carbon domains during a sol-gel process. And the micelle size could be adjusted easily by changing the preparation conditions. Accordingly, the particle size of the obtained carbon materials was effectively tuned from 20 to 100 nm by the direction of the primary micelle size. After calcination, the hierarchical porous carbon materials were evidenced as effective electrode materials for supercapacitor with a capacitance of ∼197 F at 1 A g(-1), which was almost four times higher than the carbon materials prepared by a straight HTC process.

  20. Reaping benefits from intellectual capital.

    PubMed

    Weston, Marla J; Estrada, Nicolette A; Carrington, Jane

    2007-01-01

    The wealth and value of organizations are increasingly based on intellectual capital. Although acquiring talented individuals and investing in employee learning adds value to the organization, reaping the benefits of intellectual capital involves translating the wisdom of employees into reusable and sustained actions. This requires a culture that creates employee commitment, encourages learning, fosters sharing, and involves employees in decision making. An infrastructure to recognize and embed promising and best practices through social networks, evidence-based practice, customization of innovations, and use of information technology results in increased productivity, stronger financial performance, better patient outcomes, and greater employee and customer satisfaction.

  1. Intellectuals and the Persisting Significance of Race.

    ERIC Educational Resources Information Center

    Banks, William M.; Jewell, Joseph

    1995-01-01

    Examines attitudes of 173 black thinkers about racial and ethnic identity and membership in the intellectual subsociety, and establishes an empirical basis for thinking about African American intellectuals. Survey responses and follow-up interviews with 20 subjects indicate the existence of marked differences between black and white intellectuals.…

  2. Cleartalk: Police Responding to Intellectual Disability.

    ERIC Educational Resources Information Center

    Brennan, Mark; Brennan, Roslin

    The Cleartalk project was developed in New South Wales (Australia) to help police respond to the communication needs of people with intellectual disabilities. Section 1 presents "The View from the Street: A Working Knowledge of Intellectual Disability," which discusses how individuals with intellectual disabilities are denied their right…

  3. 14 CFR 1274.208 - Intellectual property.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... NASA's General Counsel. When a waiver is granted, any inventions made in the performance of work under... organization for experimental, developmental, research, design or engineering work in support of the agreement... performance of work under the agreement are subject to certain reporting, election and filing requirements,...

  4. 14 CFR 1274.208 - Intellectual property.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... performance of work under the agreement are subject to certain reporting, election and filing requirements, a... business organization for experimental, developmental, research, design or engineering work in support of... the performance of work under the agreement are subject to certain reporting, election and...

  5. 14 CFR 1274.208 - Intellectual property.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... performance of work under the agreement are subject to certain reporting, election and filing requirements, a... business organization for experimental, developmental, research, design or engineering work in support of... the performance of work under the agreement are subject to certain reporting, election and...

  6. 10 CFR 600.325 - Intellectual property.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... rights data and/or restricted computer software, may be included. Inclusion of a background patent and/or... availability of the technology would also benefit the government, e.g., clean-up of DOE facilities. The scope..., an award will not require the delivery of limited rights data or restricted computer...

  7. 10 CFR 600.325 - Intellectual property.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... rights data and/or restricted computer software, may be included. Inclusion of a background patent and/or... availability of the technology would also benefit the government, e.g., clean-up of DOE facilities. The scope..., an award will not require the delivery of limited rights data or restricted computer...

  8. 10 CFR 600.325 - Intellectual property.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... rights data and/or restricted computer software, may be included. Inclusion of a background patent and/or... availability of the technology would also benefit the government, e.g., clean-up of DOE facilities. The scope..., an award will not require the delivery of limited rights data or restricted computer...

  9. Antibody-drug conjugates: Intellectual property considerations.

    PubMed

    Storz, Ulrich

    2015-01-01

    Antibody-drug conjugates are highly complex entities that combine an antibody, a linker and a toxin. This complexity makes them demanding both technically and from a regulatory point of view, and difficult to deal with in their patent aspects. This article discusses different issues of patent protection and freedom to operate with regard to this promising new class of drugs.

  10. Antibody-drug conjugates: Intellectual property considerations

    PubMed Central

    Storz, Ulrich

    2015-01-01

    Antibody-drug conjugates are highly complex entities that combine an antibody, a linker and a toxin. This complexity makes them demanding both technically and from a regulatory point of view, and difficult to deal with in their patent aspects. This article discusses different issues of patent protection and freedom to operate with regard to this promising new class of drugs. PMID:26292154

  11. Intellectual property issues of immune checkpoint inhibitors

    PubMed Central

    Storz, Ulrich

    2016-01-01

    Immune checkpoint inhibitors are drugs that interfere with tumor escape responses. Some members of this class are already approved, and expected to be blockbusters in the future. Many companies have developed patent activities in this field. This article focuses on the patent landscape, and discusses key players and cases related to immune checkpoint inhibitors. PMID:26466763

  12. 14 CFR 1274.208 - Intellectual property.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... royalty-free license to the Government, march-in rights, and certain other reservations. (2) A recipient... Code. The Government obtains an irrevocable, nonexclusive, royalty-free license. (e) Subcontractor... requirements, a royalty-free license to the Government, march-in rights, and certain other reservations....

  13. Patent Pools: Intellectual Property Rights and Competition

    PubMed Central

    Rodriguez, Victor

    2010-01-01

    Patent pools do not correct all problems associated with patent thickets. In this respect, patent pools might not stop the outsider problem from striking pools. Moreover, patent pools can be expensive to negotiate, can exclude patent holders with smaller numbers of patents or enable a group of major players to form a cartel that excludes new competitors. For all the above reasons, patent pools are subject to regulatory clearance because they could result in a monopoly. The aim of this article is to present the relationship between patents and competition in a broad context. PMID:20200607

  14. Intellectual Property Rights and International Trade

    DTIC Science & Technology

    2009-02-05

    year. Korea and China, along with India, Brazil, South Africa, Turkey, Mexico, and Malaysia , represented the majority of all patent filings from...on counterfeit goods seized by category . Counterfeit footwear ranked as the top commodity seized, representing $102.3 million in domestic value. Other...retaliation. For countries outside the WTO, the possibility of trade sanctions remain. The USTR also has created several administrative categories for

  15. Intellectual Property Rights and International Trade

    DTIC Science & Technology

    2008-07-23

    PhRMA, “Special 301 Submission for 2007,” Appendix: Damage Estimate Methodology, p. v . 33 PhRMA, “Special 301 Submissions for 2008.” and many other...2007, [http://www.ustr.gov]. See also CRS Report RL33536, China-U.S. Trade Issues, by Wayne M. Morrison. 35 Liza Porteus Viana , “Industry Losing Faith...2007. 88 “Peru IPR Text Reflects FTA Template, Shows Reduced PhRMA Sway,” Inside US Trade, July 6, 2007. 89 Liza Porteus Viana , “USTR Plans Another

  16. 10 CFR 600.325 - Intellectual property.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOE, or if other special circumstances exist, e.g., DOE specifying “open-source” treatment of software... statute, other than those providing for the Small Business Innovation Research (SBIR) and Small...

  17. 10 CFR 600.325 - Intellectual property.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... rights data and/or restricted computer software, may be included. Inclusion of a background patent and/or..., an award will not require the delivery of limited rights data or restricted computer software..., determines that delivery of limited rights data or restricted computer software is necessary, the...

  18. The Relationship of Self-Injurious Behavior and Other Maladaptive Behaviors among Individuals with Severe and Profound Intellectual Disability

    ERIC Educational Resources Information Center

    Matson, Johnny L.; Cooper, Christopher; Malone, Carrie J.; Moskow, Sheree L.

    2008-01-01

    Participants were 101 individuals with self-injurious behavior (SIB) and severe or profound intellectual disability who were matched by gender, age, and level of intellectual disability to controls. Persons with SIB were more likely to exhibit the challenging behaviors of physical aggression, property destruction, sexually inappropriate behaviors…

  19. Estimating the severity of intellectual disability in adults: a Mokken scaling analysis of the Learning Disability Screening Questionnaire.

    PubMed

    Murray, Aja L; McKenzie, Karen

    2013-09-01

    A Mokken scaling analysis of the learning disability screening questionnaire (LDSQ) suggested that, with the exception of 1 item, the scale conforms to the properties of a Mokken scale. This has advantages for estimating the severity of intellectual disability and inferring the difficulties likely to be experienced by an individual for whom there is incomplete information on intellectual and adaptive functioning.

  20. Access, Intellectual Freedom and Libraries.

    ERIC Educational Resources Information Center

    Darling, Richard L.

    1979-01-01

    Reviews attitudes toward censorship in the United States throughout its history in relation to the nation and its institutions. The library is recognized as an institution in which censorship has no place, due to its creed of information access and intellectual freedom for all. (MBR)

  1. What is an Intellectual Disability?

    MedlinePlus

    ... play, and feel support from loving families and good friends. What can you do? If you know someone who has an intellectual disability, be a friend. How? Sometimes, it might mean telling a teacher if you see this person being teased or ...

  2. Gramsci, Freire, and Intellectual Life

    ERIC Educational Resources Information Center

    Roberts, Peter

    2004-01-01

    This article reflects on Peter Mayo's synthesis of ideas from two key figures in critical educational studies: Gramsci and Freire. The author identifies a number of distinguishing features of Mayo's work and considers some of the implications of his analysis for our understanding of transformative intellectual activity.

  3. Intellectual Disabilities and Hearing Loss

    ERIC Educational Resources Information Center

    Herer, Gilbert R.

    2012-01-01

    Undetected/untreated hearing loss imposes significant limitations upon individuals with intellectual disabilities (ID). It can interfere with cognitive development, impede communicative and social interactions, and limit vocational aspirations. Over the past decade, the hearing of 9961 people with ID was evaluated at Special Olympics sports…

  4. A New Day for Intellectuals

    ERIC Educational Resources Information Center

    Delbanco, Andrew

    2009-01-01

    Soon after election day, the columnist Nicholas D. Kristof wrote in "The New York Times" that the "second most remarkable thing" about the election was that "American voters have just picked a president who is an open, out-of-the-closet, practicing intellectual." Surely, one of the secrets of President Obama's rhetorical power is his ability to…

  5. The Economist as Public Intellectual

    ERIC Educational Resources Information Center

    Hubbard, R. Glenn

    2004-01-01

    Over the past two decades, the rising number of outlets for communication through cable networks and electronic broadcasting (not to mention self-promoting Web "blogs") has stimulated the demand for economic commentary. Only the academic economist, as "public intellectual," can provide this commentary in a coherent and rigorous way via the three…

  6. Remembering PESA: An Intellectual Journey

    ERIC Educational Resources Information Center

    Evers, Colin W.

    2009-01-01

    This author's interest in philosophy derived from a passion for mathematics that developed in middle high school, which he attended in Sydney. In this article, he provides a self-portrait of his intellectual life and his involvement with the Philosophy of Education Society of Australasia (PESA). He states that despite the research demands of his…

  7. What is an Intellectual Disability?

    MedlinePlus

    ... helmet and always wear a seatbelt in the car!) Doctors figure out that someone has an intellectual disability by testing how well the person thinks and solves problems. If a problem is spotted, doctors and other professionals can work with the family to decide what type of ...

  8. Cost Estimation of a Health-Check Intervention for Adults with Intellectual Disabilities in the UK

    ERIC Educational Resources Information Center

    Romeo, R.; Knapp, M.; Morrison, J.; Melville, C.; Allan, L.; Finlayson, J.; Cooper, S.-A.

    2009-01-01

    Background: High rates of health needs among adults with intellectual disabilities flag the need for information about the economic consequences of strategies to identify and address unmet needs. Health-check interventions are one such strategy, and have been demonstrated to effect health gains over the following 12-month period. However, little…

  9. Adults with Mild Intellectual Disabilities: Can Their Reading Comprehension Ability Be Improved?

    ERIC Educational Resources Information Center

    van den Bos, K. P.; Nakken, H.; Nicolay, P. G.; van Houten, E. J.

    2007-01-01

    Background: Adults with a mild intellectual disability (ID) often show poor decoding and reading comprehension skills. The goal of this study was to investigate the effects of teaching text comprehension strategies to these adults. Specific research goals were to determine (1) the effects of two instruction conditions, i.e. strategy instruction to…

  10. Integration Strategy Is a Key Step in Network-Based Analysis and Dramatically Affects Network Topological Properties and Inferring Outcomes

    PubMed Central

    Jin, Nana; Wu, Deng; Gong, Yonghui; Bi, Xiaoman; Jiang, Hong; Li, Kongning; Wang, Qianghu

    2014-01-01

    An increasing number of experiments have been designed to detect intracellular and intercellular molecular interactions. Based on these molecular interactions (especially protein interactions), molecular networks have been built for using in several typical applications, such as the discovery of new disease genes and the identification of drug targets and molecular complexes. Because the data are incomplete and a considerable number of false-positive interactions exist, protein interactions from different sources are commonly integrated in network analyses to build a stable molecular network. Although various types of integration strategies are being applied in current studies, the topological properties of the networks from these different integration strategies, especially typical applications based on these network integration strategies, have not been rigorously evaluated. In this paper, systematic analyses were performed to evaluate 11 frequently used methods using two types of integration strategies: empirical and machine learning methods. The topological properties of the networks of these different integration strategies were found to significantly differ. Moreover, these networks were found to dramatically affect the outcomes of typical applications, such as disease gene predictions, drug target detections, and molecular complex identifications. The analysis presented in this paper could provide an important basis for future network-based biological researches. PMID:25243127

  11. Properties of different selection signature statistics and a new strategy for combining them.

    PubMed

    Ma, Y; Ding, X; Qanbari, S; Weigend, S; Zhang, Q; Simianer, H

    2015-11-01

    Identifying signatures of recent or ongoing selection is of high relevance in livestock population genomics. From a statistical perspective, determining a proper testing procedure and combining various test statistics is challenging. On the basis of extensive simulations in this study, we discuss the statistical properties of eight different established selection signature statistics. In the considered scenario, we show that a reasonable power to detect selection signatures is achieved with high marker density (>1 SNP/kb) as obtained from sequencing, while rather small sample sizes (~15 diploid individuals) appear to be sufficient. Most selection signature statistics such as composite likelihood ratio and cross population extended haplotype homozogysity have the highest power when fixation of the selected allele is reached, while integrated haplotype score has the highest power when selection is ongoing. We suggest a novel strategy, called de-correlated composite of multiple signals (DCMS) to combine different statistics for detecting selection signatures while accounting for the correlation between the different selection signature statistics. When examined with simulated data, DCMS consistently has a higher power than most of the single statistics and shows a reliable positional resolution. We illustrate the new statistic to the established selective sweep around the lactase gene in human HapMap data providing further evidence of the reliability of this new statistic. Then, we apply it to scan selection signatures in two chicken samples with diverse skin color. Our analysis suggests that a set of well-known genes such as BCO2, MC1R, ASIP and TYR were involved in the divergent selection for this trait.

  12. Psychometric Properties of the Motivated Strategies for Learning Questionnaire for Sultan Qaboos University Students

    ERIC Educational Resources Information Center

    Alkharusi, Hussain; Neisler, Otherine; Al-Barwani, Thuwayba; Clayton, David; Al-Sulaimani, Humaira; Khan, Mohammad; Al-Yahmadi, Hamad; Al-Kalbani, Muna

    2012-01-01

    Research on university student learning has suggested that students' motivational orientations and learning strategies are critical to their academic achievement. In an attempt to assess the levels of motivation and the usage of learning resources and strategies of college students, Pintrich, Smith, Garcia and McKeachie (1993) developed an 81-item…

  13. Scalable Downstream Strategies for Purification of Recombinant Adeno-Associated Virus Vectors in Light of the Properties

    PubMed Central

    Qu, Weihong; Wang, Mingxi; Wu, Yaqing; Xu, Ruian

    2015-01-01

    Recombinant adeno-associated virus (rAAV) vector is one of the promising delivery tools for gene therapy. Currently, hundreds of clinical trials are performed but the major barrier for clinical application is the absence of any ideal large scale production technique to obtain sufficient and highly pure rAAV vector. The large scale production technique includes upstream and downstream processing. The upstream processing is a vector package step and the downstream processing is a vector purification step. For large scale downstream processing, the scientists need to recover rAAV from dozens of liters of cell lysate or medium, and a variety of purification strategies have been developed but not comprehensively compared till now. Consequently, this review will evaluate the scalable downstream purification strategies systematically, especially those based on the physicochemical properties of AAV virus, and attempt to find better scalable downstream strategies for rAAV vectors.

  14. A general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosides.

    PubMed

    Mulani, Shaheen K; Guh, Jih-Hwa; Mong, Kwok-Kong Tony

    2014-05-14

    A general strategy for the synthesis of phenylethanoid glycosides (PhG) including echinacoside 1, acteoside 2, calceolarioside-A 3 and calceolarioside-B 4 is reported. The strategy features the application of low substrate concentration glycosylation and N-formyl morpholine modulated glycosylation methods for the construction of 1,2-trans β- and α-glycosidic bonds. The reported strategy does not invoke the use of the participatory acyl protecting function, which is incompatible with the ester function present in target PhG compounds. A preliminary study of the anti-proliferation properties of the PhG compounds 1–4 was performed; the acteoside 2 exhibited the best inhibition on the prostatic cancer cell proliferation.

  15. Developmental Defects of Enamel in Children with Intellectual Disability

    PubMed Central

    Erika, Vesna; Modrić; Karlović, Zoran

    2016-01-01

    Objectives To investigate the frequency of developmental defects of enamel (DDE) in children with intellectual disability. Subjects and methods Children aged 5–18 years (72 children with intellectual disabilities and 72 controls) were included in the study. All the teeth were screened for developmental defects of enamel using the modified Developmental defects of enamel (mDDE) index. Results Out of the 72 children with intellectual disabilities in this study, 20 (27.78%) presented dental defects of enamel, compared with 8 (11.11%) of those in the control group, which was considered statistically significant (p = 0.021). The majority of children in both groups had white demarcated opacities. Children in both groups were more likely to have maxillary teeth affected than the mandibular teeth and the asymmetrical demarcated enamel defects were more common than the symmetric ones. Majority of opacities in children in both groups were on the maxillary incisors. Conclusions Children with intellectual disabilities have more developmental defects of enamel than children in the control group. Enamel defects increase caries risk and cause reduction in enamel mechanical properties leading to restoration failures. PMID:27688428

  16. Consumers with an intellectual disability and carers: perceptions of interactions with banks.

    PubMed

    Hayes, Susan C; Martin, Fiona B

    2007-03-01

    As more people with an intellectual disability reside independently in the community, there is both the need and the opportunity for them to use financial services, including banks and credit unions, and products such as cash machine cards, credit cards and loans. There is a dearth of information about interactions between consumers with intellectual disabilities and their carers, and financial service providers. This study investigated the perceptions of 94 consumers with an intellectual disability and 53 carers regarding interactions with financial service providers. Consumers and carers mentioned a number of problems with banks, and reported a low rate of successful resolution of these difficulties. Carers mentioned more problems than consumers, and more frequently reported intangible problems such as discrimination. The 'digital divide' was evident, with few consumers having access to Internet or telephone banking. People with intellectual disabilities need education programmes about electronic banking, their rights as consumers and their access to problem resolution strategies.

  17. Control by technological mode parameters with an intellectual automated system

    NASA Astrophysics Data System (ADS)

    Stupina, A. A.; Shigina, A. A.; Shigin, A. O.; Karaseva, M. V.; Korpacheva, L. N.

    2016-11-01

    The scheme of functional correlation of input and output parameters of the "drilling rig - rolling cutter bit - rock" system is proposed. The necessity to apply drilling rigs of the automated intellectual system with the adaptive element for a quick time response of the investigated system on the change of physical and mechanical rock properties and the maintenance of the adjusted operating parameters of the technical system in an optimal ratio.

  18. Fruit flies and intellectual disability

    PubMed Central

    Bolduc, François V.; Tully, Tim

    2011-01-01

    Mental retardation—known more commonly nowadays as intellectual disability—is a severe neurological condition affecting up to 3% of the general population. As a result of the analysis of familial cases and recent advances in clinical genetic testing, great strides have been made in our understanding of the genetic etiologies of mental retardation. Nonetheless, no treatment is currently clinically available to patients suffering from intellectual disability. Several animal models have been used in the study of memory and cognition. Established paradigms in Drosophila have recently captured cognitive defects in fly mutants for orthologs of genes involved in human intellectual disability. We review here three protocols designed to understand the molecular genetic basis of learning and memory in Drosophila and the genes identified so far with relation to mental retardation. In addition, we explore the mental retardation genes for which evidence of neuronal dysfunction other than memory has been established in Drosophila. Finally, we summarize the findings in Drosophila for mental retardation genes for which no neuronal information is yet available. All in all, this review illustrates the impressive overlap between genes identified in human mental retardation and genes involved in physiological learning and memory. PMID:19182539

  19. Balancing public health, trade and intellectual monopoly privileges: recent Australian IP legislation and the TPPA.

    PubMed

    Vines, Tim; Crow, Kim; Faunce, Thomas

    2012-12-01

    Over the past year, several significant reforms to Australia's intellectual property regime have been proposed and passed by Parliament. The Intellectual Property Laws Amendment (Raising the Bar) Act 2012 (Cth) made various improvements to Australian patent law, including an improved threshold for patentability, greater clarity around "usefulness" requirements, and the introduction of an experimental use exemption from infringement. Another Bill, the Intellectual Property Laws Amendment Bill 2012 (Cth), currently out for public consultation, would implement a 2003 decision of the World Trade Organisation (WTO) General Council and the 2005 Doha Declaration on the TRIPS Agreement and Public Health (Doha Declaration). If enacted, this Bill would facilitate equitable access to essential medicines by amending the compulsory licensing regime set out in the Patents Act 1990 (Cth). The underlying intention of this Bill--meeting public health goals outlined in the 2005 Doha Declaration--stands in juxtaposition to proposed reforms to intellectual property standards pursuant to the Trans-Pacific Partnership Trade and Investment Agreement (TPPA) that Australia is involved in. Although at a preliminary stage, leaked drafts of relevant intellectual property provisions in the TPPA suggest a privileging of patent monopoly privileges over public health goals. This column weighs the sentiments of the proposed Bill against those of the proposed provisions in the TPPA.

  20. Development Strategies for Herbal Products Reducing the Influence of Natural Variance in Dry Mass on Tableting Properties and Tablet Characteristics

    PubMed Central

    Qusaj, Ylber; Leng, Andreas; Alshihabi, Firas; Krasniqi, Blerim; Vandamme, Thierry

    2012-01-01

    One “Quality by Design” approach is the focus on the variability of the properties of the active substance. This is crucially important for active substances that are obtained from natural resources such as herbal plant material and extracts. In this paper, we present various strategies for the development of herbal products especially taking into account the natural batch-to-batch variability (mainly of the dry mass) of tablets that contain a fixed amount of tincture. The following steps in the development have been evaluated for the outcome of the physico-chemical properties of the resulting tablets and intermediates: concentration of the tincture extracted from Echinacea fresh plant, loading of the concentrate onto an inert carrier, the respective wet granulation and drying step, including milling, and the adjuvant excipients for the tablet compression step. The responses that were investigated are the mean particle size of the dried and milled granulates, compaction properties and disintegration time of the tablets. Increased particle size showed a significant increase of the disintegration time and a decrease of the compaction properties. In addition, our results showed that the particle size has a great dependency on the ratio of liquid to carrier during the wet granulation process. Thus, the variability of the respective parameters tested was influenced by the performed strategies, which is how the tincture correlated to its dry mass and the relation of the amount of carrier used. In order to optimize these parameters, a strategy considering the above-mentioned points has to be chosen. PMID:24300367

  1. The Relation between Intellectual Functioning and Adaptive Behavior in the Diagnosis of Intellectual Disability

    ERIC Educational Resources Information Center

    Tassé, Marc J.; Luckasson, Ruth; Schalock, Robert L.

    2016-01-01

    Intellectual disability originates during the developmental period and is characterized by significant limitations both in intellectual functioning and in adaptive behavior as expressed in conceptual, social, and practical adaptive skills. In this article, we present a brief history of the diagnostic criteria of intellectual disability for both…

  2. A strategy for Bayesian inference for computationally expensive models with application to the estimation of stem cell properties.

    PubMed

    Overstall, Antony M; Woods, David C

    2013-06-01

    Bayesian inference is considered for statistical models that depend on the evaluation of a computationally expensive computer code or simulator. For such situations, the number of evaluations of the likelihood function, and hence of the unnormalized posterior probability density function, is determined by the available computational resource and may be extremely limited. We present a new example of such a simulator that describes the properties of human embryonic stem cells using data from optical trapping experiments. This application is used to motivate a novel strategy for Bayesian inference which exploits a Gaussian process approximation of the simulator and allows computationally efficient Markov chain Monte Carlo inference. The advantages of this strategy over previous methodology are that it is less reliant on the determination of tuning parameters and allows the application of model diagnostic procedures that require no additional evaluations of the simulator. We show the advantages of our method on synthetic examples and demonstrate its application on stem cell experiments.

  3. X-linked intellectual disability related genes disrupted by balanced X-autosome translocations.

    PubMed

    Moysés-Oliveira, Mariana; Guilherme, Roberta Santos; Meloni, Vera Ayres; Di Battista, Adriana; de Mello, Claudia Berlim; Bragagnolo, Silvia; Moretti-Ferreira, Danilo; Kosyakova, Nadezda; Liehr, Thomas; Carvalheira, Gianna Maria; Melaragno, Maria Isabel

    2015-12-01

    Detailed molecular characterization of chromosomal rearrangements involving X-chromosome has been a key strategy in identifying X-linked intellectual disability-causing genes. We fine-mapped the breakpoints in four women with balanced X-autosome translocations and variable phenotypes, in order to investigate the corresponding genetic contribution to intellectual disability. We addressed the impact of the gene interruptions in transcription and discussed the consequences of their functional impairment in neurodevelopment. Three patients presented with cognitive impairment, reinforcing the association between the disrupted genes (TSPAN7-MRX58, KIAA2022-MRX98, and IL1RAPL1-MRX21/34) and intellectual disability. While gene expression analysis showed absence of TSPAN7 and KIAA2022 expression in the patients, the unexpected expression of IL1RAPL1 suggested a fusion transcript ZNF611-IL1RAPL1 under the control of the ZNF611 promoter, gene disrupted at the autosomal breakpoint. The X-chromosomal breakpoint definition in the fourth patient, a woman with normal intellectual abilities, revealed disruption of the ZDHHC15 gene (MRX91). The expression assays did not detect ZDHHC15 gene expression in the patient, thus questioning its involvement in intellectual disability. Revealing the disruption of an X-linked intellectual disability-related gene in patients with balanced X-autosome translocation is a useful tool for a better characterization of critical genes in neurodevelopment. © 2015 Wiley Periodicals, Inc.

  4. Psychometric Comparisons of Three Measures for Assessing Motor Functions in Preschoolers with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Wuang, Y-P.; Su, C-Y.; Huang, M-H.

    2012-01-01

    Background: Deficit in motor performance is common in children with intellectual disabilities (ID). A motor function measure with sound psychometric properties is indispensable for clinical and research use. The purpose of this study was to compare the psychometric properties of three commonly used clinical measures for assessing motor function in…

  5. A straightforward strategy toward large BN-embedded π-systems: synthesis, structure, and optoelectronic properties of extended BN heterosuperbenzenes.

    PubMed

    Wang, Xiao-Ye; Zhuang, Fang-Dong; Wang, Rui-Bo; Wang, Xin-Chang; Cao, Xiao-Yu; Wang, Jie-Yu; Pei, Jian

    2014-03-12

    A straightforward strategy has been used to construct large BN-embedded π-systems simply from azaacenes. BN heterosuperbenzene derivatives, the largest BN heteroaromatics to date, have been synthesized in three steps. The molecules exhibit curved π-surfaces, showing two different conformations which are self-organized into a sandwich structure and further packed into a π-stacking column. The assembled microribbons exhibit good charge transport properties and photoconductivity, representing an important step toward the optoelectronic applications of BN-embedded aromatics.

  6. Poverty and People with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Emerson, Eric

    2007-01-01

    Epidemiological studies have consistently reported a significant association between poverty and the prevalence of intellectual disabilities. The available evidence suggests that this association reflects two distinct processes. First, poverty causes intellectual disabilities, an effect mediated through the association between poverty and exposure…

  7. Women and International Intellectual Co-Operation

    ERIC Educational Resources Information Center

    Goodman, Joyce

    2012-01-01

    The article explores ways in which intellectual co-operation at the League of Nations [SDN] provided a space for the engagement of culturally elite women in intellectual co-operation circles in Geneva, Paris and a range of national contexts stretching across Europe, Latin America and Asia. It discusses the language of the "international mind" and…

  8. Maintaining Intellectual Freedom in a Filtered World

    ERIC Educational Resources Information Center

    Johnson, Doug

    2005-01-01

    The concepts of intellectual freedom as expressed in these two quotations are as relevant to information in electronic formats as they are in print. As a proponent of intellectual freedom, the author of this article advocated and received administrative support for unfiltered Internet access in the Mankato Area (Minnesota) Public Schools from 1994…

  9. Religious Expression amongst Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Turner, Susannah; Hatton, Chris; Shah, Robina; Stansfield, Julie; Rahim, Nabela

    2004-01-01

    Background: Although religion is an important part of many people's lives, little is known about the role of religion in the lives of people with intellectual disabilities. Method: Semi-structured face-to-face interviews were conducted with 29 people with intellectual disabilities of a range of faiths (various Christian denominations, Islam and…

  10. Exemplary Teachers: Teaching for Intellectual Freedom

    ERIC Educational Resources Information Center

    Collinson, Vivienne

    2012-01-01

    Intellectual freedom has long been a desirable ideal and a foundational value for supporting democratic governance. Since 1948, it has been a universal human right. Given the unique nature of education in democratic societies, schools serve as a crucible for helping children understand and practise the rudiments of intellectual freedom. Drawing on…

  11. Intellectual Freedom and Censorship in the Library

    ERIC Educational Resources Information Center

    Cooper, Jessica L.

    2010-01-01

    The article gives a brief description of intellectual freedom and censorship in order to set a foundation for looking into the library community's role in advocating for intellectual freedom and combating censorship. Focus is given to the unique challenges of school libraries in fulfilling the larger library community's expectations in these two…

  12. An Education Belief Worth Reflection: Molding Intellectuals

    ERIC Educational Resources Information Center

    Lu, Jie

    2006-01-01

    Molding intellectuals is one of the expectations people have, which comes from a deep-rooted belief in education. The humanity hypothesis of this belief is to take knowledge and the pursuit of knowledge as the only prescription for human beings. This hypothesis overturns the relation of knowledge and life. Intellectuals make scientific paradigm as…

  13. The Family Dynamics of Intellectual Development.

    ERIC Educational Resources Information Center

    Zajonc, R. B.

    2001-01-01

    Birth order effects on intellectual performance show both positive and negative results. Considers the intellectual aspects of siblings' changing environments, explaining that birth order and family size effects depend crucially on the age at which children are tested. Within-family data conceal patterns of aggregate effects that are revealed by…

  14. The Saint Mary's Woman: toward Intellectual Leadership.

    ERIC Educational Resources Information Center

    White, Patrick E.

    This two-year project at Saint Mary's College, a women's college in Notre Dame (Indiana), focused on building intellectual community and fostering student leadership skills. The study targeted two student groups: (1) students with much to contribute to the intellectual life of the college but alienated from traditional forms of leadership, and (2)…

  15. Fostering Successful Intellectual Styles for Creativity

    ERIC Educational Resources Information Center

    Zhang, Li-fang

    2015-01-01

    Intellectual styles refer to people's preferred ways of processing information and dealing with tasks. Individuals who have a propensity for using a wide range of styles--always including creativity-generating styles--are said to possess successful intellectual styles. The author argues that teachers should and can encourage creativity among…

  16. INTEGRATED DEVELOPMENT, MOTOR APTITUDE AND INTELLECTUAL PERFORMANCE.

    ERIC Educational Resources Information Center

    GRUBER, J.J.; ISMAIL, A.H.

    THE RELATIONSHIP OF MOVEMENT RESPONSES TO LEARNING ACHIEVEMENT WERE INVESTIGATED (1) TO IDENTIFY FACTORS CLAIMED TO MEASURE MOTOR APTITUDE AND INTELLECTUAL ACHIEVEMENT IN PRE-ADOLESCENTS, (2) TO DEVELOP MOTOR APTITUDE TEST BATTERIES FOR PREDICTING INTELLECTUAL ACHIEVEMENT, (3) TO STUDY RELATIONSHIPS OF COORDINATION AND BALANCE TEST ITEMS IN…

  17. Executive Functions in Individuals with Intellectual Disability

    ERIC Educational Resources Information Center

    Danielsson, Henrik; Henry, Lucy; Ronnberg, Jerker; Nilsson, Lars-Goran

    2010-01-01

    The aim of the present study was to investigate executive functions in adults with intellectual disability, and compare them to a closely matched control group longitudinally for 5 years. In the Betula database, a group of adults with intellectual disability (ID, n = 46) was defined from measures of verbal and non-verbal IQ. A control group, with…

  18. Intellectual Freedom and the Bible College Library

    ERIC Educational Resources Information Center

    Smith, Gregory A.

    2004-01-01

    A number of evangelical Christian authors have wrestled with the subject of intellectual freedom--few, though, in the context of Bible college libraries. The secular concept of intellectual freedom is incompatible with Bible colleges in that it is absolutist and shuns any standard of morality. Theological, educational, and pragmatic factors…

  19. Dietary strategies to improve nutritional value, oxidative stability, and sensory properties of poultry products.

    PubMed

    Bou, Ricard; Codony, Rafael; Tres, Alba; Decker, Eric A; Guardiola, Francesc

    2009-10-01

    Consumers demand both safer and more nutritious food products exempt of non-natural origin preservatives or other food additives. In this frame, products with lower fat content and/or a higher ratio in unsaturated fatty acids, especially n-3 fatty acids, are desired because these lipids can help prevent the development of cardiovascular and inflammatory pathologies. The intake of meat products is of interest because they are an excellent source of vitamins and minerals. In addition, the shelf-life of meat products can be extended by the presence of natural antioxidants coming from different sources such as plant extracts. Therefore, different strategies have been studied to improve the nutritional value, oxidative stability, and sensory characteristics of meat products and eggs through different mineral and natural dietary supplements. In comparison to other strategies, dietary supplements present the advantage that first the living animals may efficiently distribute the compounds throughout the tissues and second, the dietary supplementation is safer because the resulting enriched meat products and eggs ensure tolerable amounts in humans. Poultry meats and eggs are widely consumed and their fatty acid profile and tocopherol content can be easily modified through different dietary strategies thus being excellent models to improve their nutritional value and oxidative stability.

  20. Influence of post-treatment strategies on the properties of activated chars from broiler manure

    Technology Transfer Automated Retrieval System (TEKTRAN)

    There are a myriad of carbonaceous precursors that can be used advantageously to produce activated carbons or chars, due to their low cost, availability and intrinsic properties. Because of the nature of the raw material, production of granular activated chars from broiler manure results in a signif...

  1. Cells Respond to Distinct Nanoparticle Properties with Multiple Strategies As Revealed by Single-Cell RNA-Seq

    SciTech Connect

    Mitchell, Hugh D.; Markillie, Lye Meng; Chrisler, William B.; Gaffrey, Matthew J.; Hu, Dehong; Szymanski, Craig J.; Xie, Yumei; Melby, Eric S.; Dohnalkova, Alice; Taylor, Ronald C.; Grate, Eva K.; Cooley, Scott K.; McDermott, Jason E.; Heredia-Langner, Alejandro; Orr, Galya

    2016-11-22

    The impact of distinct nanoparticle (NP) properties on cellular response and ultimately human health is unclear. This gap is partially due to experimental difficulties in achieving uniform NP loads in the studied cells, creating heterogeneous populations with some cells “overloaded” while other cells are loaded with few or no NPs. Yet gene expression studies have been conducted in the population as a whole, identifying generic responses, while missing unique responses due to signal averaging across many cells, each carrying different loads. Here we applied single-cell RNA-Seq to alveolar epithelial cells carrying defined loads of aminated or carboxylated quantum dots (QDs), showing higher or lower toxicity, respectively. Interestingly, cells carrying lower loads responded with multiple strategies, mostly with upregulated processes, which were nonetheless coherent and unique to each QD type. In contrast, cells carrying higher loads responded more uniformly, with mostly downregulated processes that were shared across QD types. Strategies unique to aminated QDs showed strong upregulation of stress responses, coupled in some cases with regulation of cell cycle, protein synthesis and organelle activities. In contrast, strategies unique to carboxylated QDs showed upregulation of DNA repair and RNA activities, and decreased regulation of cell division, coupled in some cases with upregulation of stress responses and ATP related functions. Together, our studies suggest scenarios where higher NP loads lock cells into uniform responses, mostly shutdown of cellular processes, whereas lower loads allow for unique responses to each NP type that are more diversified, proactive defenses or repairs of the NP insults.

  2. Assessment of Postural Adjustments in Persons with Intellectual Disability during Balance on the Seesaw

    ERIC Educational Resources Information Center

    Carvalho, R. L.; Almeida, G. L.

    2009-01-01

    Background: The purpose of this study was to investigate the kinematic and electromyography strategy used by individuals with intellectual disability to keep equilibrium during anterior-posterior balance on seesaws with different degrees of instability. Method: Six individuals with Down syndrome (DS) and six control group individuals (CG) balanced…

  3. Identifying an Optimal and Early Communication Modality for Students with Autism and Intellectual Disability

    ERIC Educational Resources Information Center

    Curtis, Daniel B.

    2012-01-01

    Research evaluating augmentative and alternative communication (AAC) options shows general support for various strategies (e.g., manual sign, picture exchange) in teaching individuals with autism (ASD) and intellectual disabilities (ID) to request basic wants and needs. However, the overall quality and quantity of research is diluted by the…

  4. The Effectiveness of Antipsychotic Medication in the Management of Behaviour Problems in Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Deb, S.; Sohanpal, S. K.; Soni, R.; Lenotre, L.; Unwin, G.

    2007-01-01

    Background: Psychopharmacological intervention in the management of behaviour problems in adults with intellectual disabilities (ID) has become a common treatment strategy. This has become a cause for concern, given that the evidence for its effectiveness is uncertain and most drugs are not licensed for this use. Methods: A comprehensive…

  5. Staff Morale in Day Care Centres for Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Mascha, Katerina

    2007-01-01

    Background: Levels of burnout, job satisfaction and intended turnover of staff working in day care centres for adults with intellectual disabilities are investigated in relation to role clarity, staff support and supervision, and coping strategies used by staff. Materials and methods: Thirty six direct-care staff of four day care centres in the UK…

  6. Video Self-Modeling: A Job Skills Intervention with Individuals with Intellectual Disability in Employment Settings

    ERIC Educational Resources Information Center

    Goh, Ailsa E.; Bambara, Linda M.

    2013-01-01

    The purpose of this study was to explore the effectiveness of video self-modeling (VSM) to teach chained job tasks to individuals with intellectual disability in community-based employment settings. Initial empirical evaluations have demonstrated that VSM when used in combination with other instructional strategies, are effective methods to teach…

  7. Teaching Elementary Students with Moderate Intellectual Disabilities How To Shop for Groceries.

    ERIC Educational Resources Information Center

    Morse, Timothy E.; Schuster, John W.

    2000-01-01

    A study investigated the effectiveness of an instructional strategy in teaching 10 elementary-aged students with moderate intellectual disabilities how to shop for groceries. Following the intervention, which consisted of in vivo training using constant time delay and simulation training using a pictorial storyboard, six students achieved…

  8. Barriers to Caregiver Compliance with Eating and Drinking Recommendations for Adults with Intellectual Disabilities and Dysphagia

    ERIC Educational Resources Information Center

    Chadwick, Darren D.; Jolliffe, Jane; Goldbart, Juliet; Burton, Mark H.

    2006-01-01

    Background: There is scant research on the subject of dysphagia and people with intellectual disabilities. This study explores the barriers which caregivers believe make following Speech and Language Therapists' (SLTs) dysphagia management strategies more difficult. Method: Semi-structured open-ended interviews were conducted with 46 caregivers…

  9. End-of-Life Care Policies in Flemish Residential Care Facilities Accommodating Persons with Intellectual Disabilities

    ERIC Educational Resources Information Center

    D'Haene, I.; Pasman, H. R. W.; Deliens, L.; Bilsen, J.; Mortier, F.; Stichele, R. Vander

    2010-01-01

    Objective: This article aims to describe the presence, content and implementation strategies of written policies on end-of-life decisions in Flemish residential care facilities (RCFs) accommodating persons with intellectual disabilities (ID), and to describe training, education and quality assessments of end-of-life care. Methods: A…

  10. Caregiving Perceptions of Chinese Mothers of Children with Intellectual Disability in Hong Kong

    ERIC Educational Resources Information Center

    Mak, Winnie W. S.; Ho, Gladys S. M.

    2007-01-01

    Background: In this study, we tested the effects of three different coping strategies (i.e. problem-focused, emotion-focused and relationship-focused coping) on both positive and negative caregiving perceptions. Materials and Methods: Two hundred and twelve Chinese mothers of children with intellectual disability from a major non-governmental…

  11. Interventions Provided by Parents for Children with Intellectual Disabilities in Low and Middle Income Countries

    ERIC Educational Resources Information Center

    Einfeld, Stewart L.; Stancliffe, Roger J.; Gray, Kylie M.; Sofronoff, Kate; Rice, Lauren; Emerson, Eric; Yasamy, M. T.

    2012-01-01

    Background: In low- and middle-income (LAMI) countries, there is a lack of well-trained therapists to provide specialist interventions for children with intellectual disabilities and their families. We sought to identify strategies deliverable by families or non-specialist workers. Materials and Methods: After searches of appropriate scientific…

  12. Intellectual Giftedness and Psychopathology in Children and Adolescents: A Systematic Literature Review

    ERIC Educational Resources Information Center

    Francis, Rosanna; Hawes, David J.; Abbott, Maree

    2016-01-01

    Using a systematic search strategy in which intellectual giftedness was operationalized in terms of IQ score, the authors examined evidence from studies reporting on associations between this aspect of giftedness and psychopathology. A total of 18 studies met the inclusion criteria: compared gifted (IQ = 125) and nongifted (IQ = 90-110) peers or…

  13. Psychological Factors in Risk Assessment and Management of Inappropriate Sexual Behaviour by Men with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Smith, Mark; Willner, Paul

    2004-01-01

    Aim: This study examined the responses of care managers and direct care staff to vignettes of inappropriate sexual behaviour (ISB) by a man with an intellectual disability. The aim was to identify psychological factors that influenced their assessment of risk and the perceived need for risk management strategies. Method: The vignettes varied in…

  14. Substance abuse among individuals with intellectual disabilities.

    PubMed

    Carroll Chapman, Shawna L; Wu, Li-Tzy

    2012-01-01

    Individuals with disabilities are a growing population that confronts multiple disadvantages from social and environmental determinants of health. In particular, the 7-8 million people in the U.S. with an intellectual disability (ID) suffer disproportionately from substance use problems, largely because of a lack of empirical evidence to inform prevention and treatment efforts for them. Although available research could inform future research efforts, studies are scattered across disciplines with the last review synthesizing findings written more than five years ago. To consider more recent findings with earlier works, PubMed, PsychINFO, and Google Scholar were searched and produced 37 peer-reviewed texts across multiple disciplines, 15 from 2006 or later. While the prevalence of alcohol and illicit drug use in this population are low, the risk of having a substance-related problem among ID substance users is comparatively high. Gaps in the research and population subgroups that warrant special attention are identified, such as individuals with borderline and mild ID, individuals with co-occurring mental illness, and individuals who are incarcerated. Compared with substance abusers without ID, ID substance abusers are less likely to receive substance abuse treatment or remain in treatment. Research is needed to better gauge the magnitude of substance use problems, identify prevention strategies, and specify treatment components that meet the unique needs of individuals with ID.

  15. Molecular tandem repeat strategy for elucidating mechanical properties of high-strength proteins

    PubMed Central

    Jung, Huihun; Pena-Francesch, Abdon; Saadat, Alham; Sebastian, Aswathy; Kim, Dong Hwan; Hamilton, Reginald F.; Albert, Istvan; Allen, Benjamin D.; Demirel, Melik C.

    2016-01-01

    Many globular and structural proteins have repetitions in their sequences or structures. However, a clear relationship between these repeats and their contribution to the mechanical properties remains elusive. We propose a new approach for the design and production of synthetic polypeptides that comprise one or more tandem copies of a single unit with distinct amorphous and ordered regions. Our designed sequences are based on a structural protein produced in squid suction cups that has a segmented copolymer structure with amorphous and crystalline domains. We produced segmented polypeptides with varying repeat number, while keeping the lengths and compositions of the amorphous and crystalline regions fixed. We showed that mechanical properties of these synthetic proteins could be tuned by modulating their molecular weights. Specifically, the toughness and extensibility of synthetic polypeptides increase as a function of the number of tandem repeats. This result suggests that the repetitions in native squid proteins could have a genetic advantage for increased toughness and flexibility. PMID:27222581

  16. Molecular tandem repeat strategy for elucidating mechanical properties of high-strength proteins.

    PubMed

    Jung, Huihun; Pena-Francesch, Abdon; Saadat, Alham; Sebastian, Aswathy; Kim, Dong Hwan; Hamilton, Reginald F; Albert, Istvan; Allen, Benjamin D; Demirel, Melik C

    2016-06-07

    Many globular and structural proteins have repetitions in their sequences or structures. However, a clear relationship between these repeats and their contribution to the mechanical properties remains elusive. We propose a new approach for the design and production of synthetic polypeptides that comprise one or more tandem copies of a single unit with distinct amorphous and ordered regions. Our designed sequences are based on a structural protein produced in squid suction cups that has a segmented copolymer structure with amorphous and crystalline domains. We produced segmented polypeptides with varying repeat number, while keeping the lengths and compositions of the amorphous and crystalline regions fixed. We showed that mechanical properties of these synthetic proteins could be tuned by modulating their molecular weights. Specifically, the toughness and extensibility of synthetic polypeptides increase as a function of the number of tandem repeats. This result suggests that the repetitions in native squid proteins could have a genetic advantage for increased toughness and flexibility.

  17. Improvement on Physical Properties of Pullulan Films by Novel Cross-Linking Strategy.

    PubMed

    Chen, Chieh-Ting; Chen, Kuan-I; Chiang, Hsin-Han; Chen, Yu-Kuo; Cheng, Kuan-Chen

    2017-01-01

    Pullulan based films possess several advantages, including high transparency, low toxicity, good biodegradability, good mechanical properties, and low oxygen permeability, are preferable for food packaging. The application of pullulan films on food packaging, however, has inherent disadvantage of high water solubility. In this study, glutaraldehyde and glycerol were used as the cross-linking reagent and the plasticizer respectively to improve water resistance and physical properties of the pullulan films. Effects of cross-linking degree on physical properties, including water absorptions, swelling behaviors, water vapor permeability and tensile strengths of films were evaluated. FTIR results demonstrated that the pullulan films were successfully cross-linked by glutaraldehyde. The tensile strength of pullulan films could be enhanced significantly (P < 0.05) when glutaraldehyde was between 1% and 5% (w/w); nevertheless, the amount of glutaraldehyde above 20% (w/w) led to films brittleness. With the addition of glycerol as a plasticizer enhanced the extensibility of films as well as the hydrophilicity, resulting in higher water vapor permeability.

  18. Increasing Social Interaction Skills of Secondary School Students with Autism and/or Intellectual Disability: A Review of Interventions

    ERIC Educational Resources Information Center

    Hughes, Carolyn; Kaplan, Lauren; Bernstein, Rebekah; Boykin, Michaela; Reilly, Caitlin; Brigham, Nicolette; Cosgriff, Joseph; Heilingoetter, Jamie; Harvey, Michelle

    2012-01-01

    We reviewed studies to identify strategies effective at increasing social interaction skills across a range of secondary school students with autism and/or intellectual disability who experienced limited peer interaction. We were particularly interested in identifying strategies that involved peers and were effective at increasing peer interaction…

  19. Academics and practitioners: nurses as intellectuals.

    PubMed

    Holmes, Colin A

    2002-06-01

    Academics and practitioners: nurses as intellectuals In the author's experience, nurse educators working in universities generally accept that they are 'academics', but dismiss suggestions that they are 'intellectuals' because they see it as a pretentious description referring to a small number of academics and aesthetes who inhabit a conceptual world beyond the imaginative capacity of most other people. This paper suggests that the concept of the 'intellectual', if not the word itself, be admitted into nursing discourse through the adoption of a non-élitist Gramscian understanding, similar to the more recently formulated conception of the reflective practitioner. According to the Italian Marxist scholar Antonio Gramsci, intellectuals are those people who develop ways in which to construct the conditions of their own existence, a possibility he believed was open to all. It is suggested that, from a Gramscian perspective, all nurses are intellectuals to varying degrees, and nurse educators should not only be nurturing their own intellectualism but also the potential for intellectualism as it exists within each individual. The ways in which this project are related to Habermasian critical theory are also briefly outlined.

  20. Children with intellectual disability and hospice utilization.

    PubMed

    Lindley, Lisa C; Colman, Mari Beth; Meadows, John T

    2017-02-01

    Over 42,000 children die each year in the United States, including those with intellectual disability (ID). Survival is often reduced when children with intellectual disability also suffer from significant motor dysfunction, progressive congenital conditions, and comorbidities. Yet, little is known about hospice care for children with intellectual disability. The purpose of this study was to explore the relationship between intellectual disability and hospice utilization. Additionally, we explored whether intellectual disability combined with motor dysfunction, progressive congenital conditions, and comorbidities influenced pediatric hospice utilization. Using a retrospective cohort design and data from the 2009 to 2010 California Medicaid claims files, we conducted a multivariate analysis of hospice utilization. This study shows that intellectual disability was negatively related to hospice enrollment and length of stay. We also found that when children had both intellectual disability and comorbidities, there was a positive association with enrolling in hospice care. A number of clinical implications can be drawn from the study findings that hospice and palliative care nurses use to improve their clinical practice of caring for children with ID and their families at end of life.

  1. Intellectually Gifted Rural-to-Urban Migrant Children's Attention

    ERIC Educational Resources Information Center

    Zhang, Hui; He, Yunfeng; Tao, Ting; Shi, Jian-Nong

    2016-01-01

    The term "intellectually gifted rural-to-urban migrant children" refers to intellectually gifted children who are in migration from rural to urban areas. We compared performances on seven attention tasks among intellectually gifted (n = 26) and average (n = 30) rural-to-urban migrant and intellectually gifted urban children (n = 31). Our…

  2. Is Intellectual Character Growth a Realistic Educational Aim?

    ERIC Educational Resources Information Center

    Baehr, Jason

    2016-01-01

    Responsibilist approaches to virtue epistemology examine the epistemic significance of intellectual virtues like curiosity, attentiveness, intellectual humility, open-mindedness, intellectual courage, and intellectual tenacity. On one way of thinking about these traits, they are the deep personal qualities or character traits of a good thinker or…

  3. ADME properties of herbal medicines in humans: evidence, challenges and strategies.

    PubMed

    He, Shu-Ming; Chan, Eli; Zhou, Shu-Feng

    2011-01-01

    Herbal medicines, an important group of multicomponent therapeutics, are widely and increasignly used worldwide. Despite the popularitiy of herbal medicines, the clinical evidence that support the use of most herbal medicines is weak. Pharmacokinetic and absorption, distribution, metabolism and excretion (ADME) studies have been integrated into modern drug development, but ADME studies are generally not needed for herbal remedy discovery and development. For the majority of herbal medicines, data on their ADME and pharmacokinetic properties in humans are lacking or scant. An extensive literature search indicates that there are limited data on ADME properties of herbal medicines in humans. Many herbal compounds undergo Phase I and/or Phase II metabolism in vivo, with cytochrome P450s (CYPs) and uridine diphosphate glucuronosyltransferases (UGTs) playing a major role. Some herbal ingredients are substrates of P-glycoprotein (P-gp/MDR1/ABCB1) which is highly expressed in the intestine, liver, brain and kidney. As such, the activities of these drug metabolizing enzymes and drug transporters are critical determining factors for the in vivo ADME processes of herbal remedies. There are increasing ADME studies of herbal remedies, but these studies are mainly focused on a small number of herbal medicines including St John's wort, milk thistle, curcumin, echinacea, ginseng, ginkgo, and ginger. For an herbal medicine, the pharmacological activity is gained when the active agents or the active metabolites reach and sustain proper levels at their sites of action. Both the dose levels and ADME processes of active herbal components in the body govern their target-site concentrations and thus the therapeutic responses. In this regard, a safe and optimal use of herbal medicines requires a full understanding of their ADME profiles. To optimize the use of herbal remedies, further studies to explore their ADME properties in humans are certainly warranted.

  4. Rethinking traditional methods for measuring intellectual capital.

    PubMed

    Corso, John A

    2007-01-01

    Historically, approaches to measuring intellectual capital have included both conventional accounting-based measures, such as variants of the market-to-book ratio, and more progressive measures, such as the measurement of intangible assets found in approaches such as the Balanced Scorecard and Human Resource Accounting. As greater emphasis is placed on intellectual capital and its various aspects in the continually growing service and knowledge economy, the use of assessment instruments to inventory the alignment, balance, and variety of intellectual capacities and metrics that assess the effectiveness of succession planning may represent new directions in which organizations can head in the measurement of this important construct.

  5. Dynamic control over cell adhesive properties using molecular-based surface engineering strategies.

    PubMed

    Robertus, Jort; Browne, Wesley R; Feringa, Ben L

    2010-01-01

    In complex organisms, cells are often dependent on their extracellular matrix (ECM) for structural integrity, the mechanical properties of tissues, and for signaled regulation of cellular processes including adhesion, migration, growth, secretion, gene expression and apoptosis. Achieving dynamic control, i.e. by using an external stimulus, over the interactions between cells and artificial interfaces holds considerable promise in tissue engineering, medicine, cell biology and immunology. For example, improved spatial control over cell-surface interaction is potentially useful in the design of cell-based screening devices. Dynamic control over SAMs for cell adhesion provides an additional handle to direct and study the attachment of cells to surfaces, e.g., in studying cell spreading from a predetermined pattern in order to screen the cytotoxicity of drug candidates. However, 'reversible' control of cell adhesion onto substrates is an area that is still in its infancy. In this critical review recent developments in cell adhesion of mammalian cells to SAM-modified surfaces, the physical properties of which can be controlled by an external stimulus, e.g. by light, electrochemistry, etc., are discussed (118 references).

  6. Auditory attention strategy depends on target linguistic properties and spatial configurationa)

    PubMed Central

    McCloy, Daniel R.; Lee, Adrian K. C.

    2015-01-01

    Whether crossing a busy intersection or attending a large dinner party, listeners sometimes need to attend to multiple spatially distributed sound sources or streams concurrently. How they achieve this is not clear—some studies suggest that listeners cannot truly simultaneously attend to separate streams, but instead combine attention switching with short-term memory to achieve something resembling divided attention. This paper presents two oddball detection experiments designed to investigate whether directing attention to phonetic versus semantic properties of the attended speech impacts listeners' ability to divide their auditory attention across spatial locations. Each experiment uses four spatially distinct streams of monosyllabic words, variation in cue type (providing phonetic or semantic information), and requiring attention to one or two locations. A rapid button-press response paradigm is employed to minimize the role of short-term memory in performing the task. Results show that differences in the spatial configuration of attended and unattended streams interact with linguistic properties of the speech streams to impact performance. Additionally, listeners may leverage phonetic information to make oddball detection judgments even when oddballs are semantically defined. Both of these effects appear to be mediated by the overall complexity of the acoustic scene. PMID:26233011

  7. Engineering strategies to recapitulate epithelial morphogenesis within synthetic 3 dimensional extracellular matrix with tunable mechanical properties

    PubMed Central

    Miroshnikova, Y.A.; Jorgens, D.M.; Spirio, L.; Auer, M.; Sieminski-Sarang, A.L.; Weaver, V.M.

    2011-01-01

    The mechanical properties (e.g. stiffness) of the extracellular matrix (ECM) influence cell fate and tissue morphogenesis and contribute to disease progression. Nevertheless, our understanding of the mechanisms by which ECM rigidity modulates cell behavior and fate remains rudimentary. To address this issue, a number of two and three dimensional (3D) hydrogel systems have been used to explore the effects of mechanical properties of the ECM on cell behavior. Unfortunately, many of these systems have limited application because fiber architecture, adhesiveness and/or pore size often change in parallel when gel elasticity is varied. Here we describe the use of ECM-adsorbed, synthetic, self-assembling peptide gels (SAPs) that are able to recapitulate normal epithelial acini morphogenesis and gene expression in a 3D context. By exploiting the range of visco-elasticity attainable with these SAP gels, and their ability to recreate native-like ECM fibril topology with minimal variability in ligand density and pore size, we were able to reconstitute normal versus tumor-like phenotype and gene expression patterns in nonmalignant mammary epithelial cells (MECs). Accordingly, this SAP hydrogel system presents the first tunable system capable of independently assessing the interplay between ECM stiffness and multi-cellular epithelial phenotype in a 3D context. PMID:21441648

  8. Association of Lifetime Intellectual Enrichment with Cognitive Decline in the Older Population

    PubMed Central

    Vemuri, Prashanthi; Lesnick, Timothy G.; Przybelski, Scott A.; Machulda, Mary; Knopman, David S.; Mielke, Michelle M.; Roberts, Rosebud O.; Geda, Yonas E.; Rocca, Walter A.; Petersen, Ronald C.; Jack, Clifford R.

    2014-01-01

    IMPORTANCE Intellectual lifestyle enrichment throughout life is increasingly viewed as a protective strategy against commonly observed cognitive decline in the elderly. OBJECTIVE To investigate the association of lifetime intellectual enrichment with baseline cognitive performance and rate of cognitive decline in a non-demented elderly population and to estimate difference (in years) associated with lifetime intellectual enrichment to the onset of cognitive impairment. DESIGN, SETTING, PARTICIPANTS Prospective analysis of subjects enrolled in the Mayo Clinic Study of Aging (MCSA), a longitudinal population-based study of cognitive aging in Olmsted County, Minnesota. We studied 1995 non-demented (1718 cognitively normal, 277 MCI) participants in MCSA who completed intellectual lifestyle measures at baseline and underwent at least one follow-up visit. MAIN OUTCOMES AND MEASURES We studied the effect of lifetime intellectual enrichment by separating the variables into two non-overlapping principal components: education/occupation-score and mid/late-life cognitive activity measure based on self-report questionnaires. A global cognitive Z-score served as our summary cognition measure. We used linear mixed-effects models to investigate the associations of demographic and intellectual enrichment measures with global cognitive Z-score trajectories. RESULTS Baseline cognitive performance was lower in older subjects and in those with lower education/occupation, lower mid/late-life cognitive activity, apolipoprotein E4 (APOE) genotype, and in men. The interaction between the two intellectual enrichment measures was significant such that the beneficial effect of mid/late-life cognitive activity on baseline cognitive performance was reduced with increasing education/occupation. Only baseline age, mid/late-life cognitive activity, and APOE4 genotype were significantly associated with longitudinal change in cognitive performance from baseline. For APOE4 carriers with high

  9. MOF-199: A simple strategy for improvement of crystallinity and photovoltaic property

    NASA Astrophysics Data System (ADS)

    Khajavian, Ruhollah; Ghani, Kamal

    2016-12-01

    In this study, thin films of MOF-199 were prepared using a Layer-by-Layer deposition approach and applied as sensitizing materials in TiO2-based solar cells. Our results indicate that by introducing 3,4-dihydroxybenzoic acid at the interface of TiO2-MOF via a simple surface modification step, TiO2 surface roughness is reduced and texture quality of MOF-199 polycrystalline film enhances along <111> crystallographic direction while the overall conversion efficiency of the cell increases as well. The improvement in Jsc could be a consequence of enhanced crystallinity, reduced surface roughness and enhanced light-harvesting properties of surface-modified photoanode. Dark I-V characteristics of the cells also indicate that the interfacial charge recombination at TiO2-MOF interface is inhibited upon introducing DHBA thus, Voc is improved.

  10. Ultrasonic Nakagami imaging: a strategy to visualize the scatterer properties of benign and malignant breast tumors.

    PubMed

    Tsui, Po-Hsiang; Yeh, Chih-Kuang; Liao, Yin-Yin; Chang, Chien-Cheng; Kuo, Wen-Hung; Chang, King-Jen; Chen, Chiung-Nien

    2010-02-01

    Previous studies have demonstrated the usefulness of the Nakagami parameter in characterizing breast tumors by ultrasound. However, physicians or radiologists may need imaging tools in a clinical setting to visually identify the properties of breast tumors. This study proposed the ultrasonic Nakagami image to visualize the scatterer properties of breast tumors and then explored its clinical performance in classifying benign and malignant tumors. Raw data of ultrasonic backscattered signals were collected from 100 patients (50 benign and 50 malignant cases) using a commercial ultrasound scanner with a 7.5 MHz linear array transducer. The backscattered signals were used to form the B-scan and the Nakagami images of breast tumors. For each tumor, the average Nakagami parameter was calculated from the pixel values in the region-of-interest in the Nakagami image. The receiver operating characteristic (ROC) curve was used to evaluate the clinical performance of the Nakagami image. The results showed that the Nakagami image shadings in benign tumors were different from those in malignant cases. The average Nakagami parameters for benign and malignant tumors were 0.69 +/- 0.12 and 0.55 +/- 0.12, respectively. This means that the backscattered signals received from malignant tumors tend to be more pre-Rayleigh distributed than those from benign tumors, corresponding to a more complex scatterer arrangement or composition. The ROC analysis showed that the area under the ROC curve was 0.81 +/- 0.04 and the diagnostic accuracy was 82%, sensitivity was 92% and specificity was 72%. The results showed that the Nakagami image is useful to distinguishing between benign and malignant breast tumors.

  11. Cellulose reinforced nylon-6 nanofibrous membrane: Fabrication strategies, physicochemical characterizations, wicking properties and biomimetic mineralization.

    PubMed

    Joshi, Mahesh Kumar; Tiwari, Arjun Prasad; Maharjan, Bikendra; Won, Ko Sung; Kim, Han Joo; Park, Chan Hee; Kim, Cheol Sang

    2016-08-20

    The aim of the present study is to develop a facile, efficient approach to reinforce nylon 6 (N6) nanofibers with cellulose chains as well as to study the effect that cellulose regeneration has on the physicochemical properties of the composite fibers. Here, a cellulose acetate (CA) solution (17wt%) was prepared in formic acid and was blended with N6 solution (20%, prepared in formic acid and acetic acid) in various proportions, and the blended solutions were then electrospun to produce hybrid N6/CA nanofibers. Cellulose was regenerated in-situ in the fiber via alkaline saponification of the CA content of the hybrid fiber, leading to cellulose-reinforced N6 (N6/CL) nanofibers. Electron microscopy studies suggest that the fiber diameter and hence pore size gradually decreases as the mass composition of CA increases in the electrospinning solution. Cellulose regeneration showed noticeable change in the polymorphic behavior of N6, as observed in the XRD and IR spectra. The strong interaction of the hydroxyl group of cellulose with amide group of N6, mainly via hydrogen bonding, has a pronounced effect on the polymorphic behavior of N6. The γ-phase was dominant in pristine N6 and N6/CA fibers while α- phase was dominant in the N6/CL fibers. The surface wettability, wicking properties, and the tensile stress were greatly improved for N6/CL fibers compared to the corresponding N6/CA hybrid fibers. Results of DSC/TGA revealed that N6/CL fibers were more thermally stable than pristine N6 and N6/CA nanofibers. Furthermore, regeneration of cellulose chain improved the ability to nucleate bioactive calcium phosphate crystals in a simulated body fluid solution.

  12. Exploring the intellectual structure of nanoscience and nanotechnology: journal citation network analysis

    NASA Astrophysics Data System (ADS)

    Jo, Haejin; Park, Yongtae; Kim, Sarah Eunkyung; Lee, Hakyeon

    2016-06-01

    Understanding the research trends and intellectual structure of nanoscience and nanotechnology (nano) is important for governments as well as researchers. This paper investigates the intellectual structure of nano field and explores its interdisciplinary characteristics through journal citation networks. The nano journal network, where 41 journals are nodes and citation among the journals are links, is constructed and analyzed using centrality measures and brokerage analysis. The journals that have high centrality scores are identified as important journals in terms of knowledge flow. Moreover, an intermediary role of each journal in exchanging knowledge between nano subareas is identified by brokerage analysis. Further, the nano subarea network is constructed and investigated from the macro view of nano field. This paper can provide the micro and macro views of intellectual structure of nano field and therefore help researchers who seek appropriate journals to acquire knowledge and governments who develop R&D strategies for nano.

  13. Cells Respond to Distinct Nanoparticle Properties with Multiple Strategies As Revealed by Single-Cell RNA-Seq.

    PubMed

    Mitchell, Hugh D; Markillie, Lye Meng; Chrisler, William B; Gaffrey, Matthew J; Hu, Dehong; Szymanski, Craig J; Xie, Yumei; Melby, Eric S; Dohnalkova, Alice; Taylor, Ronald C; Grate, Eva K; Cooley, Scott K; McDermott, Jason E; Heredia-Langner, Alejandro; Orr, Galya

    2016-11-22

    The impact of distinct nanoparticle (NP) properties on cellular response and ultimately human health is unclear. This gap is partially due to experimental difficulties in achieving uniform NP loads in the studied cells, creating heterogeneous populations with some cells "overloaded" while other cells are loaded with few or no NPs. Yet gene expression studies have been conducted in the population as a whole, identifying generic responses, while missing unique responses due to signal averaging across many cells, each carrying different loads. Here, we applied single-cell RNA-Seq to alveolar epithelial cells carrying defined loads of aminated or carboxylated quantum dots (QDs), showing higher or lower toxicity, respectively. Interestingly, cells carrying lower loads responded with multiple strategies, mostly with up-regulated processes, which were nonetheless coherent and unique to each QD type. In contrast, cells carrying higher loads responded more uniformly, with mostly down-regulated processes that were shared across QD types. Strategies unique to aminated QDs showed strong up-regulation of stress responses, coupled in some cases with regulation of cell cycle, protein synthesis, and organelle activities. In contrast, strategies unique to carboxylated QDs showed up-regulation of DNA repair and RNA activities and decreased regulation of cell division, coupled in some cases with up-regulation of stress responses and ATP-related functions. Together, our studies suggest scenarios where higher NP loads lock cells into uniform responses, mostly shutdown of cellular processes, whereas lower loads allow for unique responses to each NP type that are more diversified proactive defenses or repairs of the NP insults.

  14. Cells respond to distinct nanoparticle properties with multiple strategies as revealed by single-cell RNA-Seq

    DOE PAGES

    Mitchell, Hugh D.; Markillie, Lye Meng; Chrisler, William B.; ...

    2016-10-27

    The impact of distinct nanoparticle (NP) properties on cellular response and ultimately human health is unclear. This gap is partially due to experimental difficulties in achieving uniform NP loads in the studied cells, creating heterogeneous populations with some cells “overloaded” while other cells are loaded with few or no NPs. Yet gene expression studies have been conducted in the population as a whole, identifying generic responses, while missing unique responses due to signal averaging across many cells, each carrying different loads. In this paper, we applied single-cell RNA-Seq to alveolar epithelial cells carrying defined loads of aminated or carboxylated quantummore » dots (QDs), showing higher or lower toxicity, respectively. Interestingly, cells carrying lower loads responded with multiple strategies, mostly with up-regulated processes, which were nonetheless coherent and unique to each QD type. In contrast, cells carrying higher loads responded more uniformly, with mostly down-regulated processes that were shared across QD types. Strategies unique to aminated QDs showed strong up-regulation of stress responses, coupled in some cases with regulation of cell cycle, protein synthesis, and organelle activities. In contrast, strategies unique to carboxylated QDs showed up-regulation of DNA repair and RNA activities and decreased regulation of cell division, coupled in some cases with up-regulation of stress responses and ATP-related functions. Finally, together, our studies suggest scenarios where higher NP loads lock cells into uniform responses, mostly shutdown of cellular processes, whereas lower loads allow for unique responses to each NP type that are more diversified proactive defenses or repairs of the NP insults.« less

  15. Cells respond to distinct nanoparticle properties with multiple strategies as revealed by single-cell RNA-Seq

    SciTech Connect

    Mitchell, Hugh D.; Markillie, Lye Meng; Chrisler, William B.; Gaffrey, Matthew J.; Hu, Dehong; Szymanski, Craig J.; Xie, Yumei; Melby, Eric S.; Dohnalkova, Alice; Taylor, Ronald C.; Grate, Eva K.; Cooley, Scott K.; McDermott, Jason E.; Heredia-Langner, Alejandro; Orr, Galya

    2016-10-27

    The impact of distinct nanoparticle (NP) properties on cellular response and ultimately human health is unclear. This gap is partially due to experimental difficulties in achieving uniform NP loads in the studied cells, creating heterogeneous populations with some cells “overloaded” while other cells are loaded with few or no NPs. Yet gene expression studies have been conducted in the population as a whole, identifying generic responses, while missing unique responses due to signal averaging across many cells, each carrying different loads. In this paper, we applied single-cell RNA-Seq to alveolar epithelial cells carrying defined loads of aminated or carboxylated quantum dots (QDs), showing higher or lower toxicity, respectively. Interestingly, cells carrying lower loads responded with multiple strategies, mostly with up-regulated processes, which were nonetheless coherent and unique to each QD type. In contrast, cells carrying higher loads responded more uniformly, with mostly down-regulated processes that were shared across QD types. Strategies unique to aminated QDs showed strong up-regulation of stress responses, coupled in some cases with regulation of cell cycle, protein synthesis, and organelle activities. In contrast, strategies unique to carboxylated QDs showed up-regulation of DNA repair and RNA activities and decreased regulation of cell division, coupled in some cases with up-regulation of stress responses and ATP-related functions. Finally, together, our studies suggest scenarios where higher NP loads lock cells into uniform responses, mostly shutdown of cellular processes, whereas lower loads allow for unique responses to each NP type that are more diversified proactive defenses or repairs of the NP insults.

  16. Study on the microstructure, mechanical property and residual stress of SLM Inconel-718 alloy manufactured by differing island scanning strategy

    NASA Astrophysics Data System (ADS)

    Lu, Yanjin; Wu, Songquan; Gan, Yiliang; Huang, Tingting; Yang, Chuanguang; Junjie, Lin; Lin, Jinxin

    2015-12-01

    Inconel-718 has received an extensive using in mold industry. The selective laser melting (SLM) is providing an ideal means for manufacturing mold insert with complex geometrical features and internal architecture. During the manufacturing of high quality mold inserts with conformal cooling channel, the parameters play a vital role in the SLM process. In the study, the Inconel-718 alloys were manufactured by SLM with 2×2 mm2, 3×3 mm2, 5×5 mm2, and 7×7 mm2 island scanning strategies. The microstructure, mechanical property, and residual stress were investigated by optical microscope, tensile test and Vickers micro-indentation, respectively. It can be found that the relative density increased with enlarging the island size; the results on the microstructure indicated that the cracks and more pores were detected in the 22-specimen; whilst the microstructures of all specimens were composed of fine dendritic grains, cellular, and columnar structures; the tensile testing suggested that the ultimate tensile strength and yield strength of all samples was similar; while the outcome of the residual stress showed that the value of residual stress was ranked in the following sequence: 22-specimen<55-specimen<77-specimen<33-specimen. Although the 22-specimen had lower residual stress compared with the other groups, the occurrence of cracks limited its processing application in SLM. Through integrated into account, the 55-scanning strategy is a promising candidate for manufacturing of mold inserts.

  17. Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

    DOE PAGES

    Zhu, Xiaojie; Zhu, Yun; Ye, Sheng; ...

    2015-08-19

    Enfuvirtide (T20), is the first HIV fusion inhibitor approved for treatment of HIV/AIDS patients who fail to respond to the current antiretroviral drugs. However, its clinical application is limited because of short half-life, drug resistance and cross-reactivity with the preexisting antibodies in HIV-infected patients. Using an artificial peptide strategy, we designed a peptide with non-native protein sequence, AP3, which exhibited potent antiviral activity against a broad spectrum of HIV-1 strains, including those resistant to T20, and had remarkably longer in vivo half-life than T20. While the preexisting antibodies in HIV-infected patients significantly suppressed T20’s antiviral activity, these antibodies neither recognizedmore » AP3, nor attenuated its anti-HIV-1 activity. Structurally different from T20, AP3 could fold into single-helix and interact with gp41 NHR. The two residues, Met and Thr, at the N-terminus of AP3 form a hook-like structure to stabilize interaction between AP3 and NHR helices. Therefore, AP3 has potential for further development as a new HIV fusion inhibitor with improved antiviral efficacy, resistance profile and pharmacological properties over enfuvirtide. Meanwhile, this study highlighted the advantages of artificially designed peptides, and confirmed that this strategy could be used in developing artificial peptide-based viral fusion inhibitors against HIV and other enveloped viruses.« less

  18. Cerebral creatine deficiencies: a group of treatable intellectual developmental disorders.

    PubMed

    Stockler-Ipsiroglu, Sylvia; van Karnebeek, Clara D M

    2014-07-01

    Currently there are 91 treatable inborn errors of metabolism that cause intellectual developmental disorders. Cerebral creatine deficiencies (CDD) comprise three of these: arginine: glycine amidinotransferase [AGAT], guanidinoacetate methyltransferase [GAMT], and X-linked creatine transporter deficiency [SLC6A8]. Intellectual developmental disorder and cerebral creatine deficiency are the hallmarks of CDD. Additional clinical features include prominent speech delay, autism, epilepsy, extrapyramidal movement disorders, and signal changes in the globus pallidus. Patients with GAMT deficiency exhibit the most severe clinical spectrum. Myopathy is a distinct feature in AGAT deficiency. Guanidinoacetate (GAA) is the immediate product in the creatine biosynthetic pathway. Low GAA concentrations in urine, plasma, and cerebrospinal fluid are characteristic diagnostic markers for AGAT deficiency, while high GAA concentrations are characteristic markers for GAMT deficiency. An elevated ratio of urinary creatine /creatinine excretion serves as a diagnostic marker in males with SLC6A8 deficiency. Treatment strategies include oral supplementation of high-dose creatine-monohydrate for all three CDD. Guanidinoacetate-reducing strategies (high-dose ornithine, arginine-restricted diet) are additionally employed in GAMT deficiency. Supplementation of substrates for intracerebral creatine synthesis (arginine, glycine) has been used additionally to treat SLC6A8 deficiency. Early recognition and treatment improves outcomes. Normal outcomes in neonatally ascertained siblings from index families with AGAT and GAMT deficiency suggest a potential benefit of newborn screening for these disorders.

  19. Indicator Properties of Baltic Zooplankton for Classification of Environmental Status within Marine Strategy Framework Directive

    PubMed Central

    Lehtiniemi, Maiju; Postel, Lutz; Rubene, Gunta; Amid, Callis; Lesutiene, Jurate; Uusitalo, Laura; Strake, Solvita; Demereckiene, Natalja

    2016-01-01

    The European Marine Strategy Framework Directive requires the EU Member States to estimate the level of anthropogenic impacts on their marine systems using 11 Descriptors. Assessing food web response to altered habitats is addressed by Descriptor 4 and its indicators, which are being developed for regional seas. However, the development of simple foodweb indicators able to assess the health of ecologically diverse, spatially variable and complex interactions is challenging. Zooplankton is a key element in marine foodwebs and thus comprise an important part of overall ecosystem health. Here, we review work on zooplankton indicator development using long-term data sets across the Baltic Sea and report the main findings. A suite of zooplankton community metrics were evaluated as putative ecological indicators that track community state in relation to Good Environmental Status (GES) criteria with regard to eutrophication and fish feeding conditions in the Baltic Sea. On the basis of an operational definition of GES, we propose mean body mass of zooplankton in the community in combination with zooplankton stock measured as either abundance or biomass to be applicable as an integrated indicator that could be used within the Descriptor 4 in the Baltic Sea. These metrics performed best in predicting zooplankton being in-GES when considering all datasets evaluated. However, some other metrics, such as copepod biomass, the contribution of copepods to the total zooplankton biomass or biomass-based Cladocera: Copepoda ratio, were equally reliable or even superior in certain basin-specific assessments. Our evaluation suggests that in several basins of the Baltic Sea, zooplankton communities currently appear to be out-of-GES, being comprised by smaller zooplankters and having lower total abundance or biomass compared to the communities during the reference conditions; however, the changes in the taxonomic structure underlying these trends vary widely across the sea basins due to

  20. American Association on Intellectual and Developmental Disabilities

    MedlinePlus

    ... Submissions Copyrights/Permissions Translation Rights Advertising Supports Intensity Scale Publications Catalog News & Policy News Press Releases News ... Definition FAQs on Intellectual Disability Diagnostic Adaptive Behavior Scale Videos About AAIDD Contact Us Mission Governance Presidential ...

  1. Mortality in People with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Heslop, Pauline; Lauer, Emily; Hoghton, Matt

    2015-01-01

    This paper reviews why an understanding of mortality data in general, and in relation to people with intellectual disabilities in particular, is an important area of concern, and introduces the papers in this Special Edition.

  2. Identification of Intellectually Able Disadvantaged Filipino Children.

    ERIC Educational Resources Information Center

    Naval-Severino, Teresita

    1992-01-01

    Preschool Filipino children from disadvantaged urban communities were assessed for giftedness. This article describes the identification procedures and tools used and presents a profile of the children in terms of socioeconomic, intellectual, and personality variables. (Author/JDD)

  3. Administration on Intellectual and Developmental Disabilities

    MedlinePlus

    ... Services on a broad range of topics that impact people with intellectual disabilities and the field of ... voters with disabilities. Protection and Advocacy for Assistive Technology Assistive technology can be an integral part of ...

  4. Reifications of the intellectual: representations, organization and agency in revolutionary China.

    PubMed

    U, Eddy

    2013-12-01

    How did 'intellectuals' evolve from a class of subjects in Marxian thoughts to highly visible populations under communism? Such 'reifications of the intellectual' have deeply affected subjectivity, conflict and organization, but received little attention in the political sociology of communism. This essay draws on research on classifications and social boundaries to address the objective and subjective foundations of the reifications and their impact on communist rule. The intellectual is viewed as an identification formed and performed around multiple social axes (most notably family background, educational achievement, occupational history, institutional affiliation and revolutionary rank) that reflected broader patterns of communist political domination. I use the Chinese Communist movement to demonstrate that (1) interaction of political contests, ruling strategies and institutional developments turned a diversity of persons into 'intellectuals' who were allegedly imbued with reprehensible interests and habits linked to privileged economic classes; (2) constant competitions for power and organizational changes led to classificatory ambiguities and, in turn, allowed individuals some control over their identifications; and (3) the developments profoundly influenced identity, state and class formation. Focusing on the dynamics that produced a highly visible but fluid population of 'intellectuals' opens new pathways for comparative research on communism.

  5. Public perceptions of intellectual disability in a shantytown community in Lima, Peru

    PubMed Central

    O’Shea, Michele S.; Girón, J. Maziel; Cabrera, Lilia; Lescano, Andrés G.; Taren, Douglas L.

    2012-01-01

    Summary Disability is the result of interactions between biological and environmental factors including the physical, economic, and social barriers imposed on an individual by society. In low and middle-income countries, limited attention has been given to the situation of individuals with intellectual disabilities, who remain seriously neglected. Given the lack of resources available to address mental disorders, it is essential to examine the role of socioeconomic and socio-cultural factors in the lives of these individuals. We conducted interviews of key informants and community members in a shantytown community in Lima, Peru, to explore public knowledge, perceptions, and attitudes regarding intellectual disability. Findings indicated that the most important concern for community members was the longstanding issues associated with poverty. There was a profound lack of awareness of intellectual disability among the general population and an absence of social integration for these individuals. However, interviewees also recognized the productive potential of persons with intellectual disabilities provided they received currently inaccessible support services. The results suggest that educational efforts and intervention strategies must be mindful of the challenges of chronic poverty in order to successfully facilitate the social integration of individuals with intellectual disabilities into the community. PMID:23268202

  6. Intellectual Disability: A Critical Concept Analysis.

    PubMed

    Pariseau-Legault, Pierre; Holmes, Dave

    2015-01-01

    Over the last number of years, the emergence of new scientific and social constructions of intellectual disability has contributed to many terminological, conceptual, and structural changes. As a result, the expression "mental retardation" has gradually been abandoned in favor of "intellectual disability" for classification and diagnosis. In addition to helping redefine intellectual disability, the implementation of new deinstitutionalized mechanisms of governmentality required the adoption of different clinical models. Concrete applications of those models have yet to be studied in nursing practice. The main objective of this article is to analyze the concept of intellectual disability in light of recent developments to clarify its philosophical bases, influence, and relevance for clinical practice. This concept analysis was realized following a literature review of scientific articles and monographs addressing topics related to intellectual disability. Inspired by a poststructuralist approach, we will discuss about the ambiguity of nurses' role regarding people labeled as having an intellectual disability. Lastly, we will address the clinical implications of our analysis and we will propose an actualized understanding of the nursing practice in such context.

  7. Freeze Dried Quetiapine-Nicotinamide Binary Solid Dispersions: A New Strategy for Improving Physicochemical Properties and Ex Vivo Diffusion

    PubMed Central

    Al-Remawi, Mayyas Mohammad Ahmad

    2016-01-01

    Improving the physicochemical properties and oral bioavailability of quetiapine fumarate (QF) enabling enhanced antipsychotic attributes are the main aims of this research. The freeze dried solid dispersion strategy was adopted using nicotinamide (NIC) as highly soluble coformer. The prepared dispersions were characterized using scanning electron microscopy (SEM) differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). Static disc intrinsic dissolution rate and ex vivo diffusion through intestinal tissues were conducted and compared to pure quetiapine fumarate. The results demonstrated a highly soluble coamorphous system formed between quetiapine fumarate and nicotinamide at 1 : 3 molar ratio through H-bonding interactions. The results showed >14-fold increase in solubility of QF from the prepared dispersions. Increased intrinsic dissolution rate (from 0.28 to 0.603 mg cm−2 min−1) and faster flux rate through duodenum (from 0.027 to 0.041 mg cm−2 h−1) and jejunum (0.027 to 0.036 mg cm−2 h−1) were obtained. The prepared coamorphous dispersion proved to be effective in improving the drug solubility and dissolution rate and ex vivo diffusion. Therefore, binary coamorphous dispersions could be a promising solution to modify the physicochemical properties, raise oral bioavailability, and change the biopharmaceutics classification (BCS) of some active pharmaceutical ingredients. PMID:28042494

  8. Hinge-like structure induced unusual properties of black phosphorus and new strategies to improve the thermoelectric performance

    PubMed Central

    Qin, Guangzhao; Yan, Qing-Bo; Qin, Zhenzhen; Yue, Sheng-Ying; Cui, Hui-Juan; Zheng, Qing-Rong; Su, Gang

    2014-01-01

    We systematically investigated the geometric, electronic and thermoelectric (TE) properties of bulk black phosphorus (BP) under strain. The hinge-like structure of BP brings unusual mechanical responses such as anisotropic Young's modulus and negative Poisson's ratio. A sensitive electronic structure of BP makes it transform among metal, direct and indirect semiconductors under strain. The maximal figure of merit ZT of BP is found to be 0.72 at 800 K that could be enhanced to 0.87 by exerting an appropriate strain, revealing BP could be a potential medium-high temperature TE material. Such strain-induced enhancements of TE performance are often observed to occur at the boundary of the direct-indirect band gap transition, which can be attributed to the increase of degeneracy of energy valleys at the transition point. By comparing the structure of BP with SnSe, a family of potential TE materials with hinge-like structure are suggested. This study not only exposes various novel properties of BP under strain, but also proposes effective strategies to seek for better TE materials. PMID:25374306

  9. Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma

    PubMed Central

    Chakraborty, Biswajit; Pal, Ramkrishna; Ali, Mohammed; Singh, Leichombam Mohindro; Shahidur Rahman, Dewan; Kumar Ghosh, Sujit; Sengupta, Mahuya

    2016-01-01

    The use of nanotechnology in nanoparticle-based cancer therapeutics is gaining impetus due to the unique biophysical properties of nanoparticles at the quantum level. Silver nanoparticles (AgNPs) have been reported as one type of potent therapeutic nanoparticles. The present study is aimed to determine the effect of AgNPs in arresting the growth of a murine fibrosarcoma by a reductive mechanism. Initially, a bioavailability study showed that mouse serum albumin (MSA)-coated AgNPs have enhanced uptake; therefore, toxicity studies of AgNP-MSA at 10 different doses (1–10 mg/kg b.w.) were performed in LACA mice by measuring the complete blood count, lipid profile and histological parameters. The complete blood count, lipid profile and histological parameter results showed that the doses from 2 to 8 mg (IC50: 6.15 mg/kg b.w.) sequentially increased the count of leukocytes, lymphocytes and granulocytes, whereas the 9- and 10-mg doses showed conclusive toxicity. In an antitumor study, the incidence and size of fibrosarcoma were reduced or delayed when murine fibrosarcoma groups were treated by AgNP-MSA. Transmission electron micrographs showed that considerable uptake of AgNP-MSA by the sentinel immune cells associated with tumor tissue and a morphologically buckled structure of the immune cells containing AgNP-MSA. Because the toxicity studies revealed a relationship between AgNPs and immune function, the protumorigenic cytokines TNF-α, IL-6 and IL-1β were also assayed in AgNP-MSA-treated and non-treated fibrosarcoma groups, and these cytokines were found to be downregulated after treatment with AgNP-MSA. PMID:25938978

  10. Behavior Problems: Differences among Intellectually Disabled Adults with Co-Morbid Autism Spectrum Disorders and Epilepsy

    ERIC Educational Resources Information Center

    Smith, Kimberly R. M.; Matson, Johnny L.

    2010-01-01

    Behavior problems such as aggression, property destruction, stereotypy, self-injurious behavior, and other disruptive behavior are commonly observed among adults with intellectual disabilities (ID), autism spectrum disorders (ASD), and epilepsy residing at state-run facilities. However, it is unknown how these populations differ on behavior…

  11. Instruments Assessing Anxiety in Adults with Intellectual Disabilities: A Systematic Review

    ERIC Educational Resources Information Center

    Hermans, Heidi; van der Pas, Femke H.; Evenhuis, Heleen M.

    2011-01-01

    Background: In the last decades several instruments measuring anxiety in adults with intellectual disabilities have been developed. Aim: To give an overview of the characteristics and psychometric properties of self-report and informant-report instruments measuring anxiety in this group. Method: Systematic review of the literature. Results:…

  12. Checklists for General Practitioner Diagnosis of Depression in Adults with Intellectual Disability

    ERIC Educational Resources Information Center

    Torr, J.; Iacono, T.; Graham, M. J.; Galea, J.

    2008-01-01

    Background: In Australia, diagnosis and management of depression in adults with intellectual disability (ID) often occurs within the primary care setting. Few tools are available to assist general practitioners (GPs) in the diagnostic process. The study aim was to assess properties of carer and GP checklists developed to address this problem.…

  13. Rasch Analysis of the Developmental Test of Visual-Motor Integration in Children with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Wuang, Yee-Pay; Su, Chwen-Yng

    2009-01-01

    The purpose of this study was to examine the measurement properties of the Developmental Test of Visual-Motor Integration (VMI) in children with intellectual disabilities (ID) ages 4-12 years using the dichotomous Rasch model. The VMI was administered individually to 454 children with ID. Rasch analysis was applied to investigate…

  14. A convenient and effective strategy for the enrichment of tumor-initiating cell properties in prostate cancer cells.

    PubMed

    Zhang, Yiming; Huang, Yiqiang; Jin, Zhong; Li, Xiezhao; Li, Bingkun; Xu, Peng; Huang, Peng; Liu, Chunxiao

    2016-09-01

    Stem-like prostate cancer (PrCa) cells, also called PrCa stem cells (PrCSCs) or PrCa tumor-initiating cells (PrTICs), are considered to be involved in the mediation of tumor metastasis and may be responsible for the poor prognosis of PrCa patients. Currently, the methods for PrTIC sorting are mainly based on cell surface marker or side population (SP). However, the rarity of these sorted cells limits the investigation of the molecular mechanisms and therapeutic strategies targeting PrTICs. For PrTIC enrichment, we induced cancer stem cell (CSC) properties in PrCa cells by transducing three defined factors (OCT3/4, SOX2, and KLF4), followed by culture with conventional serum-containing medium. The CSC properties in the transduced cells were evaluated by proliferation, cell cycle, SP assay, drug sensitivity technology, in vivo tumorigenicity, and molecular marker analysis of PrCSCs compared with parental cells and spheroids. After culture with serum-containing medium for 8 days, the PrCa cells transduced with the three factors showed significantly enhanced CSC properties in terms of marker gene expression, sphere formation, chemoresistance to docetaxel, and tumorigenicity. The percentage of CD133(+)/CD44(+) cells was ninefold higher in the transduced cell population than in the adherent PC3 cell population (2.25 ± 0.62 vs. 0.25 ± 0.12 %, respectively), and the SP increased to 1.22 ± 0.18 % in the transduced cell population, but was undetectable in the adherent population. This method can be used to obtain abundant PrTIC material and enables a complete understanding of PrTIC biology and development of novel therapeutic agents targeting PrTICs.

  15. [Intellectual honesty in abortion problems].

    PubMed

    Werner, M

    1991-04-03

    A pastor comments on the recent ruling by the Swedish Department of Health and Social Affairs that the remains of an abortion should be "treated respectfully"--cremated or buried in a cemetery. This decision results from recognition on the part of the government and the medical establishment that a growing segment of public opinion agrees that the fetus is a human being. The new rules mean, though, that a fetus becomes human only upon its death. Logically, an abortion that is respectfully performed ought not to be performed at all. This is the fundamental problem with abortion, and no amount of arbitrary boundary drawing at various levels of supposed capability for survival at the 12th, the 18th, or the 24th week of pregnancy will alter the fact. It is necessary to face the problem with complete intellectual honesty and say that a fetus is a human being no matter what its age, but that voluntary abortion is also a social necessity. Only then can society find another abortion policy, one that recognizes that late abortions are hard to distinguish from births. The Swedish abortion policy must reflect honest facts, rather than etiological legends, preconceived ideas for which arguments must be found afterward.

  16. Winning Strategies for Classroom Management.

    ERIC Educational Resources Information Center

    Cummings, Carol

    This book offers advice on arranging classrooms, diagnosing student behavior, and responding to students' emotional needs, examining intellectual, emotional, and physical challenges students face and providing strategies which help teachers create communities of learners, design classrooms, diagnose student behavior, and respond to student needs.…

  17. Pre-Trial Reported Defendants in the Netherlands with Intellectual Disability, Borderline and Normal Intellectual Functioning

    ERIC Educational Resources Information Center

    Vinkers, David J.

    2013-01-01

    Background: Intellectually disabled offenders may have different characteristics than offenders with average intellectual functioning. We therefore compared pre-trial reported defendants with an IQ score =70, 71-84 and =85 points. Methods: Nationwide database of pre-trial psychiatric reports requested by Dutch courts between 2000 and 2006 with a…

  18. Motor Performance of Children with Mild Intellectual Disability and Borderline Intellectual Functioning

    ERIC Educational Resources Information Center

    Vuijk, P. J.; Hartman, E.; Scherder, E.; Visscher, C.

    2010-01-01

    Background: There is a relatively small body of research on the motor performance of children with mild intellectual disabilities (MID) and borderline intellectual functioning (BIF). Adequate levels of motor skills may contribute to lifelong enjoyment of physical activity, participation in sports and healthy lifestyles. The present study compares…

  19. Debunking Anti-Intellectualism: An Examination of African American College Students' Intellectual Self-Concepts

    ERIC Educational Resources Information Center

    Cole, Darnell

    2011-01-01

    Framed within the debate on African American "anti-intellectualism," this study examined a longitudinal sample of 460 African American students' intellectual self-concept and college grades (GPA) through regression analyses resulting from their college experiences. The findings showed that the college environment had a modest influence on African…

  20. The Properties of Locke's Common-Wealth of Learning

    ERIC Educational Resources Information Center

    Willinksy, John

    2006-01-01

    This article reads the educational implications of "intellectual property" that are found in the double meaning of "property", as the word refers to an economic right and a quality of being. It briefly visits the seventeenth-century origins of this double concept of intellectual property (IP), with particular attention paid to…