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Sample records for interaction kn dans

  1. Low energy overlineKN interaction in nuclear matter

    NASA Astrophysics Data System (ADS)

    Waas, T.; Kaiser, N.; Weise, W.

    1996-02-01

    We investigate the low-energy overlineKN interaction in nuclear matter including Pauli blocking, Fermi motion and binding effects. We use a coupled-channel approach based on the Chiral SU(3) Effective Lagrangian which describes all available low energy data of the coupled overlineKN, πΣ, πΛ system. Due to the dynamics of the Λ (1405) resonance we find a strong non-linear density dependence of the K -p scattering amplitude in nuclear matter. The real part of the K -p scattering length changes sign already at a small fraction of nuclear matter density, less than 0.2 po. This may explain the striking behaviour of the K - -nuclear optical potential found in the analysis of kaonic atom data.

  2. KN-93 inhibits IKr in mammalian cardiomyocytes

    PubMed Central

    Hegyi, Bence; Chen-Izu, Ye; Jian, Zhong; Shimkunas, Rafael; Izu, Leighton T.; Banyasz, Tamas

    2015-01-01

    Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93 is widely used in multiple fields of cardiac research especially for studying the mechanisms of cardiomyopathy and cardiac arrhythmias. Whereas KN-93 is a potent inhibitor of CaMKII, several off-target effects have also been found in expression cell systems and smooth muscle cells, but there is no information on the KN93 side effects in mammalian ventricular myocytes. In this study we explore the effect of KN-93 on the rapid component of delayed rectifier potassium current (IKr) in the ventricular myocytes from rabbit and guinea pig hearts. Our data indicate that KN-93 exerts direct inhibitory effect on IKr that is not mediated via CaMKII. This off-target effect of KN93 should be taken into account when interpreting the data from using KN93 to investigate the role of CaMKII in cardiac function. PMID:26463508

  3. KN-93 inhibits IKr in mammalian cardiomyocytes.

    PubMed

    Hegyi, Bence; Chen-Izu, Ye; Jian, Zhong; Shimkunas, Rafael; Izu, Leighton T; Banyasz, Tamas

    2015-12-01

    Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93 is widely used in multiple fields of cardiac research especially for studying the mechanisms of cardiomyopathy and cardiac arrhythmias. Whereas KN-93 is a potent inhibitor of CaMKII, several off-target effects have also been found in expression cell systems and smooth muscle cells, but there is no information on the KN93 side effects in mammalian ventricular myocytes. In this study we explore the effect of KN-93 on the rapid component of delayed rectifier potassium current (IKr) in the ventricular myocytes from rabbit and guinea pig hearts. Our data indicate that KN-93 exerts direct inhibitory effect on IKr that is not mediated via CaMKII. This off-target effect of KN93 should be taken into account when interpreting the data from using KN93 to investigate the role of CaMKII in cardiac function.

  4. Calculations of bar K-nuclear quasi-bound states using chiral bar KN amplitudes

    NASA Astrophysics Data System (ADS)

    Mareš, J.; Barnea, N.; Cieplý, A.; Friedman, E.; Gal, A.; Gazda, D.

    2014-03-01

    We review our recent calculations of K- quasi-bound states in nuclear systems using subthreshold energy dependent chiral bar KN amplitudes. Strong energy dependence of the scattering amplitudes requires self-consistent evaluation of the involved bar KN interactions. In view of sizable widths predicted by our calculations, an unambiguous identification of K--nuclear quasi-bound states in ongoing experimental searches would be difficult.

  5. Force supplementary comparison EURAMET.M.F-S3 (1 kN, 2 kN, 5 kN, and 10 kN)

    NASA Astrophysics Data System (ADS)

    Knott, A.; Machado, R. R.

    2016-01-01

    This report describes EURAMET supplementary comparison EURAMET.M.F-S3, a comparison between the 20 kN force standard machine of NPL and the 10 kN force standard machine of INMETRO, at generated forces of 1 kN, 2 kN, 5 kN, and 10 kN, in both tension and compression, with both incremental and decremental loading. Two different transducers were used and the force-time profile was strictly controlled, to minimise effects of creep. At all four force levels, the results demonstrate that there is no evidence that either machine fails to generate forces in accordance with its CMC. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  6. Interaction soliton sable dans un canal en eau peu profonde

    NASA Astrophysics Data System (ADS)

    Marin, François; Abcha, Nizar; Brossard, Jérôme; Ezersky, Alexander

    2005-03-01

    Interaction between solitons and a sandy bed in shallow water is investigated. In our experiments, solitons are generated on the background of a harmonic wave, in a wave flume used in resonant mode. It is found that the sand ripples formed by the solitons propagation induce a significant decrease of solitons amplitude and of the phase shift between the soliton and the harmonic wave. However, the amplitude of the harmonic wave is approximately constant. The possible physical processes of such behaviour for the soliton amplitude and for the harmonic wave amplitude are discussed. To cite this article: F. Marin et al., C. R. Mecanique 333 (2005).

  7. Interactions électron-électron dans les fils mésoscopiques

    NASA Astrophysics Data System (ADS)

    Pierre, F.

    Electron-electron interactions in mesoscopic wires In metallic thin films, the screening of Coulomb interactions is less efficient than in bulk metals because of electron elastic scattering from film boundaries, lattice defects, and impurities. As a consequence, at sub-kelvin temperatures, electron-electron interactions are expected to be the dominant inelastic process undergone by electrons, which determines energy exchange and limits the electronic phase coherence. We present in this book three experiments that probe inelastic collisions experienced by electrons at low temperature, in order to find out their mechanism. In the first part, we present a series of measurements of the energy distribution function of electrons in copper, gold and silver wires driven in a steady-state, out of equilibrium situation. These experiments reveal the rate at which electrons exchange energy. These results are compared in the second part with the temperature dependence of the phase coherence time of electrons tau_{φ}, which is deduced from the magnetoresistance of long wires. The phase coherence of electrons is limited by all inelastic collisions, independently of the energy exchanged. Different mechanisms to account for the energy exchange rate and dephasing times are proposed and compared with experiments. In the third part, we present measurements of the conductance of a long tunnel junction between an aluminum wire and a ground plane. The dip in the conductance at zero voltage is expected from the theory of electron-electron interactions. To compare measurements and theoretical predictions, we rephrase the microscopic theory of electron-electron interactions in terms of an electromagnetic impedance, as is done for the phenomenological theory of Coulomb blockade. Dans les couches minces métalliques, l'écrantage des interactions coulombiennes entre électrons est moins efficace que dans les métaux massifs en raison des chocs élastiques que subissent les électrons sur les

  8. Kaonic atoms and in-medium K-N amplitudes

    NASA Astrophysics Data System (ADS)

    Friedman, E.; Gal, A.

    2012-05-01

    Recent work on the connection between in-medium subthreshold K-N amplitudes and kaonic atom potentials is updated by using a next to leading order chirally motivated coupled channel separable interaction model that reproduces K¯N observables at low energies, including the very recent SIDDHARTA results for the atomic K--hydrogen 1s level shift and width. The corresponding K--nucleus potential is evaluated self-consistently within a single-nucleon approach and is critically reviewed with respect to empirical features of phenomenological optical potentials. The need to supplement the single-nucleon based approach with multi-nucleon interactions is demonstrated by showing that additional empirical absorptive and dispersive terms, beyond the reach of chirally motivated K--nucleus potentials, are required in order to achieve good agreement with the bulk of the data on kaonic atoms.

  9. Anti-HIV-1 Activity of a New Scorpion Venom Peptide Derivative Kn2-7

    PubMed Central

    Chen, Yaoqing; Cao, Luyang; Zhong, Maohua; Zhang, Yan; Han, Chen; Li, Qiaoli; Yang, Jingyi; Zhou, Dihan; Shi, Wei; He, Benxia; Liu, Fang; Yu, Jie; Sun, Ying; Cao, Yuan; Li, Yaoming; Li, Wenxin; Guo, Deying; Cao, Zhijian; Yan, Huimin

    2012-01-01

    For over 30 years, HIV/AIDS has wreaked havoc in the world. In the absence of an effective vaccine for HIV, development of new anti-HIV agents is urgently needed. We previously identified the antiviral activities of the scorpion-venom-peptide-derived mucroporin-M1 for three RNA viruses (measles viruses, SARS-CoV, and H5N1). In this investigation, a panel of scorpion venom peptides and their derivatives were designed and chosen for assessment of their anti-HIV activities. A new scorpion venom peptide derivative Kn2-7 was identified as the most potent anti-HIV-1 peptide by screening assays with an EC50 value of 2.76 µg/ml (1.65 µM) and showed low cytotoxicity to host cells with a selective index (SI) of 13.93. Kn2-7 could inhibit all members of a standard reference panel of HIV-1 subtype B pseudotyped virus (PV) with CCR5-tropic and CXCR4-tropic NL4-3 PV strain. Furthermore, it also inhibited a CXCR4-tropic replication-competent strain of HIV-1 subtype B virus. Binding assay of Kn2-7 to HIV-1 PV by Octet Red system suggested the anti-HIV-1 activity was correlated with a direct interaction between Kn2-7 and HIV-1 envelope. These results demonstrated that peptide Kn2-7 could inhibit HIV-1 by direct interaction with viral particle and may become a promising candidate compound for further development of microbicide against HIV-1. PMID:22536342

  10. Conceptual Engine System Design for NERVA derived 66.7KN and 111.2KN Thrust Nuclear Thermal Rockets

    NASA Astrophysics Data System (ADS)

    Fittje, James E.; Buehrle, Robert J.

    2006-01-01

    The Nuclear Thermal Rocket concept is being evaluated as an advanced propulsion concept for missions to the moon and Mars. A tremendous effort was undertaken during the 1960's and 1970's to develop and test NERVA derived Nuclear Thermal Rockets in the 111.2 KN to 1112 KN pound thrust class. NASA GRC is leveraging this past NTR investment in their vehicle concepts and mission analysis studies, and has been evaluating NERVA derived engines in the 66.7 KN to the 111.2 KN thrust range. The liquid hydrogen propellant feed system, including the turbopumps, is an essential component of the overall operation of this system. The NASA GRC team is evaluating numerous propellant feed system designs with both single and twin turbopumps. The Nuclear Engine System Simulation code is being exercised to analyze thermodynamic cycle points for these selected concepts. This paper will present propellant feed system concepts and the corresponding thermodynamic cycle points for 66.7 KN and 111.2 KN thrust NTR engine systems. A pump out condition for a twin turbopump concept will also be evaluated, and the NESS code will be assessed against the Small Nuclear Rocket Engine preliminary thermodynamic data.

  11. Conceptual Engine System Design for NERVA derived 66.7KN and 111.2KN Thrust Nuclear Thermal Rockets

    SciTech Connect

    Fittje, James E.; Buehrle, Robert J.

    2006-01-20

    The Nuclear Thermal Rocket concept is being evaluated as an advanced propulsion concept for missions to the moon and Mars. A tremendous effort was undertaken during the 1960's and 1970's to develop and test NERVA derived Nuclear Thermal Rockets in the 111.2 KN to 1112 KN pound thrust class. NASA GRC is leveraging this past NTR investment in their vehicle concepts and mission analysis studies, and has been evaluating NERVA derived engines in the 66.7 KN to the 111.2 KN thrust range. The liquid hydrogen propellant feed system, including the turbopumps, is an essential component of the overall operation of this system. The NASA GRC team is evaluating numerous propellant feed system designs with both single and twin turbopumps. The Nuclear Engine System Simulation code is being exercised to analyze thermodynamic cycle points for these selected concepts. This paper will present propellant feed system concepts and the corresponding thermodynamic cycle points for 66.7 KN and 111.2 KN thrust NTR engine systems. A pump out condition for a twin turbopump concept will also be evaluated, and the NESS code will be assessed against the Small Nuclear Rocket Engine preliminary thermodynamic data.

  12. Effet de l'interaction coulombienne sur la localisation d'Anderson dans le gaz bidimensionnel d'électrons

    NASA Astrophysics Data System (ADS)

    Fleury, G.

    2010-09-01

    Nous étudions l’effet des interactions coulombiennes sur la localisation d’Anderson dans le gaz bidimensionnel d’électrons désordonné. L’objectif est de statuer sur la question de l’existence de métaux à deux dimensions. En l’absence d’interaction, la théorie d’échelle de la localisation prédit qu’un désordre infinitésimal suffit à localiser la fonction d’onde électronique et donc à rendre le système isolant à température nulle (Abrahams et al., 1979). Dans certaines limites extrêmes, les interactions peuvent être prises en compte et l’on aboutit également à un état isolant. Cependant, aucune théorie analytique ne permet de traiter le régime quantique non-perturbatif où désordre et interaction sont intermédiaires. Expérimentalement, il est possible de l’explorer dans des échantillons de haute mobilité et basse densité. Depuis 1994, des comportements métalliques inexpliqués y ont été observés (Kravchenko et al., 1994). Nous avons mis au point une méthode numérique permettant d’étudier le problème couplé de la localisation d’Anderson en présence d’interaction. Cette méthode mêle Monte Carlo quantique à température nulle et théorie d’échelle pour la conductance de Thouless. Nous trouvons que la théorie d’échelle de la localisation est préservée en présence d’interaction et donc que le gaz bidimensionnel, même corrélé, est isolant à température nulle. Nos résultats montrent de plus que les interactions délocalisent le gaz bidimensionnel et que cet effet de délocalisation est accru en présence de dégénérescence de vallées. Ils nous permettent de proposer un mécanisme simple rendant compte des principales caractéristiques des comportements métalliques observés expérimentalement.

  13. Final report on force key comparison CCM.F-K2.a and CCM.F-K2.b (50 kN and 100 kN)

    NASA Astrophysics Data System (ADS)

    Vincke, William; Zhimin, Zhang; Pusa, Aimo; Averlant, Philippe; Kumme, Rolf; Germak, Alessandro; Ueda, Kazunaga; Park, Yon-Kyu; Torres, Jorge; Burke, Ben; Langmead, Fredrik; Fank, Sinan; Knott, Andy; Bartel, Tom

    2012-01-01

    This report describes CIPM key comparison CCM.F-K2, a comparison between the deadweight force standard machines of fourteen National Measurement Institutes, at generated forces of 50 kN and 100 kN, in the period from 2004 to 2007. Two different measurement schemes were employed, one for machines capable of generating both 50 kN and 100 kN and the other using the single force of 50 kN, for machines of a lower maximum capacity than 100 kN. Multiple transducers were used and the force-time profile was strictly controlled, to minimize effects of creep. Analysis of the results took careful account of the drift of the transducers' sensitivities throughout the comparison period, as this was one of the major uncertainty contributions. The final results suggest that the nominal 50 kN forces generated at four of the fourteen laboratories (and the 100 kN forces at two of them) may be statistically significantly different from the same nominal forces generated at the other laboratories. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  14. Force key comparison CCM.F-K2.a.1 (50 kN and 100 kN)

    NASA Astrophysics Data System (ADS)

    Savarin, A.; Medina, N.; Knott, A.

    2016-01-01

    This report describes CIPM key comparison CCM.F-K2.a.1, a key comparison between force standard machines at the national measurement institutes of Argentina (INTI), Spain (CEM), and the United Kingdom (NPL), at generated forces of 50 kN and 100 kN, in the period from 2010 to 2012. Two transducers were used and the force-time profile was strictly controlled, to minimise effects of creep. The final results are linked to the KCRV determined in CIPM Key Comparison CCM.F-K2.a through the use of one common deadweight force standard machine (NPL's 120 kN machine) in the two comparison exercises. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  15. First principles study of structural, electronic and mechanical properties of alkali nitride-KN

    SciTech Connect

    Murugan, A.; Rajeswarapalanichamy, R. Santhosh, M.; Iyakutti, K.

    2015-06-24

    The structural, electronic and elastic properties of alkali- metal nitride (KN) is investigated by the first principles calculations based on density functional theory as implemented in Vienna ab-initio simulation package. At ambient pressure KN is stable in the ferromagnetic state with NaCl structure. The calculated lattice parameters are in good agreement with the available results. The electronic structure reveals that the KN is half metallic ferromagnet at normal pressure. A pressure-induced structural phase transition from NaCl to ZB phase is observed in KN. Half metallicity and ferromagnetism is maintained at all pressures.

  16. 1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle.

    PubMed Central

    Brozinick, J T; Reynolds, T H; Dean, D; Cartee, G; Cushman, S W

    1999-01-01

    Previous studies have indicated a role for calmodulin in hypoxia-and insulin-stimulated glucose transport. However, since calmodulin interacts with multiple protein targets, it is unknown which of these targets is involved in the regulation of glucose transport. In the present study, we have used the calcium-dependent calmodulin protein kinase II (CAMKII) inhibitor 1-[N, O-bis-(5-isoquinolinesulphonyl) -N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62) to investigate the possible role of this enzyme in the regulation of glucose transport in isolated rat soleus and epitrochlearis muscles. KN-62 did not affect basal 2-deoxyglucose transport, but it did inhibit both insulin- and hypoxia-stimulated glucose transport activity by 46 and 40% respectively. 1-[N,O-Bis-(1, 5-isoquinolinesulphonyl)-N-methyl-l-tyrosyl]-4-phenylpiperazine (KN-04), a structural analogue of KN-62 that does not inhibit CAMKII, had no effect on hypoxia-or insulin-stimulated glucose transport. Accordingly, KN-62 decreased the stimulated cell-surface GLUT4 labelling by a similar extent as the inhibition of glucose transport (insulin, 49% and hypoxia, 54%). Additional experiments showed that KN-62 also inhibited insulin- and hypoxia-stimulated transport by 37 and 40% respectively in isolated rat epitrochlearis (a fast-twitch muscle), indicating that the effect of KN-62 was not limited to the slow-twitch fibres of the soleus. The inhibitory effect of KN-62 on hypoxia-stimulated glucose transport appears to be specific to CAMKII, since KN-62 did not inhibit hypoxia-stimulated 45Ca efflux from muscles pre-loaded with 45Ca, or hypoxia-stimulated glycogen breakdown. Additionally, KN-62 affected neither insulin-stimulated phosphoinositide 3-kinase nor Akt activity, suggesting that the effects of KN-62 are not due to non-specific effects of this inhibitor on these regions of the insulin-signalling cascade. The results of the present study suggest that CAMKII might have a distinct role in insulin- and hypoxia

  17. Final report on force key comparison EUROMET.M.F-K2: 50 kN and 100 kN (EURAMET Project No 518)

    NASA Astrophysics Data System (ADS)

    Reis Machado, Renato; Kašpar, Petr; Weiglhofer, Erich; Kumme, Rolf; Navrozidis, George; Vámossy, Csilla; Verbeek, Jos; Wozniak, Mikolaj; Spohr, Isabel; Sandu, Ion; Wüthrich, Christian; Knott, Andy

    2014-01-01

    This report describes EURAMET Key Comparison EUROMET.M.F-K2, a comparison between the force standard machines of twelve national measurement institutes, at generated forces of 50 kN and 100 kN, in the period from 2007 to 2009. Two different measurement schemes were employed, one for machines capable of generating both 50 kN and 100 kN and the other using the single force of 50 kN, for machines of a lower maximum capacity than 100 kN. Multiple transducers were used and the force-time profile was strictly controlled, to minimise effects of creep. Analysis of the results took careful account of the drift of the transducers' sensitivities throughout the comparison period, as this was one of the major uncertainty contributions. The final results are linked to the KCRV determined in CIPM Key Comparison CCM.F-K2 through the use of two common deadweight force standard machines in the two comparison exercises. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  18. KEY COMPARISON: Force key comparison CCM.F-K1.a and CCM.F-K1.b: 5 kN and 10 kN

    NASA Astrophysics Data System (ADS)

    Pusa, Aimo

    2009-01-01

    This report describes the key comparisons named CCM.F-K1.a and CCM.F-K1.b, for force with loads of 5 kN and 10 kN. The Draft A Report, reporting the measurement results of the key comparisons, has been accepted at the force expert group meeting in Pretoria on 23 March 2004. This became Part 1 of the preliminary Draft B Report. Then, there have been several discussions to find the best way for the determination of the reference value for force values 5 kN and 10 kN in the key comparisons CCM.F-K1.a and CCM.F-K1.b. Following the meeting held in Queretaro, Mexico, by CENAM, from 3 to 5 December 2007, the reference values have been calculated for each single transducer (see chapter 2), and as one reference value for 5 kN and a second reference value for 10 kN (see chapter 3). To get a better consistency a linear model for the drift of transducers has been applied. The results have been evaluated according to the paper from M G Cox, 'The evaluation of key comparison data' (2002 Metrologia 39 589-595). Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  19. BmKn-2 scorpion venom peptide for killing oral cancer cells by apoptosis.

    PubMed

    Tong-ngam, Pirut; Roytrakul, Sittiruk; Sritanaudomchai, Hathaitip

    2015-01-01

    Scorpion venom peptides recently have attracted attention as alternative chemotherapeutic agents that may overcome the limitations of current drugs, providing specific cytotoxicity for cancer cells with an ability to bypass multidrug-resistance mechanisms, additive effects in combination therapy and safety. In the present study, BmKn-2 scorpion venom peptide and its derivatives were chosen for assessment of anticancer activities. BmKn-2 was identified as the most effective against human oral squamous cells carcinoma cell line (HSC-4) by screening assays with an IC50 value of 29 μg/ml. The BmKn-2 peptide killed HSC-4 cells through induction of apoptosis, as confirmed by phase contrast microscopy and RT-PCR techniques. Typical morphological features of apoptosis including cell shrinkage and rounding characteristics were observed in treated HSC-4 cells. The results were further confirmed by increased expression of pro-apoptotic genes such as caspase-3, -7, and -9 but decrease mRNA level of anti-apoptotic BCL-2 in BmKn-2 treated cells, as determined by RT-PCR assay. In summary, the BmKn-2 scorpion venom peptide demonstrates specific membrane binding, growth inhibition and apoptogenic activity against human oral cancer cells.

  20. VizieR Online Data Catalog: Kn 26, a new quadrupolar planetary nebula (Guerrero+, 2013)

    NASA Astrophysics Data System (ADS)

    Guerrero, M. A.; Miranda, L. F.; Ramos-Larios, G.; Vazquez, R.

    2013-03-01

    Narrow-band Hα, [NII] λ6583, and [OIII] λ5007 images of Kn 26 were acquired on June 21, 2009 using ALFOSC (Andalucia Faint Object Spectrograph and Camera) at the 2.56m Nordic Optical Telescope (NOT) of the Observatorio de Roque de los Muchachos (ORM, La Palma, Spain). Narrow-band H2 2.1218um, Brγ 2.1658um, and K continuum at 2.270um images of Kn 26 were obtained on June 27, 2010 using LIRIS at the Cassegrain focus of the 4.2m William Herschel Telescope (WHT) at the ORM. Intermediate-resolution long-slit spectra of Kn 26 were obtained on October 5, 2011 using the ALBIREO spectrograph at the 1.5m telescope of the Observatorio de Sierra Nevada (OSN), Granada, Spain. Long-slit high-dispersion spectroscopy on the Hα and [NII] λ6583 lines of Kn 26 has been acquired on June 13, 2010 using the Manchester Echelle Spectrometer (MES) mounted on the 2.1m (f/7.5) telescope at the Observatorio Astronomico Nacional de San Pedro Martir (OAN-SPM, Mexico). (2 data files).

  1. Expression of almond KNOTTED1 homologue (PdKn1) anticipates adventitious shoot initiation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background and Aims: The transcription factor encoded by the gene Knotted1 is a nuclear homeodomain protein, regulating meristematic cells at the shoot apical meristem. It has been proven that Knotted1 (KN1) has a role in the switch from an indeterminate to determinate cell fate and as such this gen...

  2. K-N amplitudes below threshold constrained by multinucleon absorption

    NASA Astrophysics Data System (ADS)

    Friedman, E.; Gal, A.

    2017-03-01

    Six widely different subthreshold K- N scattering amplitudes obtained in SU(3) chiral-model EFT approaches by fitting to low-energy and threshold data are employed in optical-potential studies of kaonic atoms. Phenomenological terms representing K- multinucleon interactions are added to the EFT-inspired single-nucleon part of the K--nucleus optical potential in order to obtain good fits to kaonic-atom strong-interaction level shifts and widths across the periodic table. Introducing as a further constraint the fractions of single-nucleon K- absorption at rest from old bubble-chamber experiments, it is found that only two of the models considered here reproduce these absorption fractions. Within these two models, the interplay between single-nucleon and multinucleon K- interactions explains features observed previously with fully phenomenological optical potentials. Radial sensitivities of kaonic atom observables are re-examined, and remarks are made on the role of 'subthreshold kinematics' in absorption-at-rest calculations.

  3. A spectroscopic and photometric study of the planetary nebulae Kn 61 and Pa 5

    SciTech Connect

    García-Díaz, Ma. T.; González-Buitrago, D.; López, J. A.; Zharikov, S.; Tovmassian, G.; Borisov, N.; Valyavin, G. E-mail: dgonzalez@astro.unam.mx E-mail: zhar@astro.unam.mx E-mail: borisov@sao.ru

    2014-09-01

    We present the first morpho-kinematical analysis of the planetary nebulae Kn 61 and Pa 5 and explore the nature of their central stars. Our analysis is based on high-resolution and medium-resolution spectroscopic observations, deep narrow-band imaging, and integral photometry. This material allows us to identify the morphological components and study their kinematics. The direct images and spectra indicate an absence of the characteristic [N II] and [S II] emission lines in both nebulae. The nebular spectrum of Kn 61 suggests a hydrogen deficient planetary nebula and the stellar spectrum of the central star reveals a hydrogen-deficient PG 1159-type star. The [O III] position velocity diagram reveals that Kn 61 is a closed, empty, spherical shell with a thin border and a filamentary surface expanding at 67.6 km s{sup –1} and the shell is currently not expanding isotropically. We derived a kinematic age of ∼1.6 × 10{sup 4} yr for an assumed distance of 4 kpc. A photometric period of ∼5.7(±0.4) days has been detected for Kn 61, indicating the presence of a possible binary system at its core. A possible link between filamentary spherical shells and PG 1159-type stars is noted. The morphology of Pa 5 is dominated by an equatorial toroid and faint polar extensions. The equatorial region of this planetary nebula is expanding at 45.2 km s{sup –1}. The stellar spectrum corresponds to a very hot star and is dominated by a steep blue rising continuum and He II, Balmer, and Ca II photospheric lines.

  4. Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner.

    PubMed

    Takeuchi, Mikio; Yamamoto, Tomoko

    2015-07-01

    Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme that catalyzes the synthesis of nicotinamide mononucleotide from nicotinamide (Nam) in the salvage pathway of mammalian NAD biosynthesis. Several potent NAMPT inhibitors have been identified and used to investigate the role of intracellular NAD and to develop therapeutics. NAD depletion induced by NAMPT inhibitors depolarizes mitochondrial membrane potential and causes apoptosis in a range of cell types. However, the mechanisms behind this depolarization have not been precisely elucidated. We observed that apoptosis of THP-1 cells in response to NAMPT inhibitors was reduced by the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93 via an unknown mechanism. The inactive analog of KN-93, KN-92, exhibited the same activity, but the CaMKII-inhibiting cell-permeable autocamtide-2-related inhibitory peptide II did not, indicating that the inhibition of THP-1 cell apoptosis was not dependent on CaMKII. In evaluating the mechanism of action, we confirmed that KN-93 did not inhibit decreases in NAD levels but did inhibit decreases in mitochondrial membrane potential, indicating that KN-93 exerts inhibition upstream of the mitochondrial pathway of apoptosis. Further, qPCR analysis of the Bcl-2 family of proteins showed that Bim is efficiently expressed following NAMPT inhibition and that KN-92 did not inhibit this expression. The L-type Ca(2+) channel blockers verapamil and nimodipine partially inhibited apoptosis, indicating that part of this effect is dependent on Ca(2+) channel inhibition, as both KN-93 and KN-92 are reported to inhibit L-type Ca(2+) channels. On the other hand, KN-93 and KN-92 did not markedly inhibit apoptosis induced by anti-cancer agents such as etoposide, actinomycin D, ABT-737, or TW-37, indicating that the mechanism of inhibition is specific to apoptosis induced by NAD depletion. These results demonstrate that NAD depletion induces a specific type of apoptosis that

  5. The Interaction of knotted1 and thick tassel dwarf1 in Vegetative and Reproductive Meristems of Maize

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In Arabidopsis, SHOOT MERISTEMLESS (STM) and CLAVATA1 (CLV1) competitively regulate meristem homeostasis. Here, we explore the interaction of their maize homologs knotted1 (kn1) and thick tassel dwarf1 (td1). kn1 mutants form fewer lateral organs and td1 inflorescences are fasciated with additional ...

  6. Special Course on Shock-Wave/Boundary-Layer Interactions in Supersonic and Hypersonic Flows (Interactions entre Ondes de Choc et Couches Limites dans les Ecoulements Supersoniques et Hpersoniques).

    DTIC Science & Technology

    1993-08-01

    This leads to a helical separation vortex. One free-interaction analysis to demonstrate that (p,/p1 ), may view this vortex as a reorganization of...34 and the development of it underpredicted his data somewhat, while the a helical separation vortex. However, the lack of upstream-influence correlation...with a sinigle experliiieit".( Cobu-.litol it ii a ia laine. \\t a. 56. pp. 149-164. 60. D. VANDROMINE. lOS0. "Turi alence miodellliAi for varial ule

  7. Meet EPA's Dan Nelson

    EPA Pesticide Factsheets

    EPA’s Dan Nelson is the Director of the Human Research Protocol Office at the National Health and Environmental Effect Research Laboratory, Dan works to protect the rights and welfare of EPA’s research participants.

  8. The mechanism for the hydrogenation of ketones catalyzed by Knölker's iron-catalyst.

    PubMed

    Lu, Xi; Zhang, Yawei; Yun, Peng; Zhang, Mingtao; Li, Tonglei

    2013-08-28

    Knölker's iron-based catalysts have some value in "green" transformations given the relatively low toxicity of iron compared to more commonly used precious-metal catalysts. Density functional methods have been used to extensively explore the use of an iron catalyst for hydrogen-transfer processes. Several inner- (with substrate coordination) and outer-sphere mechanisms (with no substrate coordination) were analyzed using a semi-simplified system. An outer-sphere route involving a concerted hydrogen-transfer to the substrate was found to be the most kinetically feasible mechanism, with a free energy barrier of only 10.2 kcal mol(-1). This mechanism was then used to explore the complete system at the same theoretical level. The real system had a higher free energy barrier (20.7 kcal mol(-1)) which is due to the steric effect of the substituent group. All the calculated results were in good agreement with the experimental results.

  9. Using computational methods to explore improvements to Knölker's iron catalyst.

    PubMed

    Lu, Xi; Zhang, Yawei; Turner, Nicholas; Zhang, Mingtao; Li, Tonglei

    2014-07-07

    Knölker's iron catalyst is characterized by low toxicity and relatively low price in comparison with precious metal catalysts. Density functional theory was used to explore improvements to this catalyst. It was found that electron-withdrawing substituents on the CpOH ring are favorable for improving the efficiency of iron catalysts. Increasing the acidity of CpOH is also an available means of improving the catalytic efficiency. However, replacing the hydroxyl of CpOH with the amino group is not a valid choice for improvement. In contrast, substituting phosphine ligands for carbonyls is the most effective method for improving the catalytic activity of the iron catalyst. But the PR3 ligand must have electron-donating groups and its steric effect should be controlled in a suitable range. Replacing carbonyl groups by PH3 and PPhH2 ligands can effectually improve the catalytic activity for hydrogenation of ketones.

  10. Kaonic atoms and in-medium K-N amplitudes II: Interplay between theory and phenomenology

    NASA Astrophysics Data System (ADS)

    Friedman, E.; Gal, A.

    2013-02-01

    A microscopic kaonic-atom optical potential VK-(1) is constructed, using the Ikeda-Hyodo-Weise NLO chiral K-N subthreshold scattering amplitudes constrained by the kaonic hydrogen SIDDHARTA measurement, and incorporating Pauli correlations within the Waas-Rho-Weise generalization of the Ericson-Ericson multiple-scattering approach. Good fits to kaonic atom data over the entire periodic table require additionally sizable K-NN-motivated absorptive and dispersive phenomenological terms, in agreement with our former analysis based on a post-SIDDHARTA in-medium chirally-inspired NLO separable model by Cieplý and Smejkal. Such terms are included by introducing a phenomenological potential VK-(2) and coupling it self-consistently to VK-(1). Properties of resulting kaonic atom potentials are discussed with special attention paid to the role of K--nuclear absorption and to the extraction of density-dependent amplitudes representing K- multi-nucleon processes.

  11. New Tables For IABG's 320kN Shaker System: Design And Procurement Process

    NASA Astrophysics Data System (ADS)

    Baumgartl, Ralf

    2012-07-01

    For more than 25 years IABG is operating its 320kN vibration system in testing of space and non-space applications. The vibration system is a multi shaker system, using four electrodynamic shakers, driving a 3x3m2 head expander and a 3x3m2 slip table. During the recent years a modernisation program of the shaker system has been implemented. The purpose of this program was to exchange system components, which have reached their expected duration of life, as well as to exchange components which did no longer fulfil the state-of-the-art requirements in testing and thus to adapt the vibration system to future challenges. Two major components of the shaker system, which have been covered during the modernisation program, are the shaker tables (the head expander and the slip table). Being the direct interface of a vibration test facility to a specimen, the shaker tables are crucial regarding the shaker system overall performance. And this fact applies even more for shaker systems with large tables, because there are no off-the-shelf solutions in this area. During the recent 5 years IABG specified, designed and procured a new head expander and a new slip table for the 320kN shaker system. This paper describes the overall process investigating on the following listed aspects: - general requirements for the tables - definition of boundary conditions and guidance principles - specific areas of interest - definition of the table material and the manufacturing method - design solutions - challenges during manufacturing - results - table properties

  12. Effects of Bacillus subtilis KN-42 on Growth Performance, Diarrhea and Faecal Bacterial Flora of Weaned Piglets

    PubMed Central

    Hu, Yuanliang; Dun, Yaohao; Li, Shenao; Zhao, Shumiao; Peng, Nan; Liang, Yunxiang

    2014-01-01

    This research focused on the effects of different doses of Bacillus subtilis KN-42 on the growth performance, diarrhea incidence, faecal bacterial flora, and the relative number of Lactobacillus and Escherichia coli in faeces of weaned piglets to determine whether the strain can serve as a candidate antimicrobial growth promoter. A total of 360 piglets (initial body weight 7.14±0.63 kg) weaned at 26±2 days of age were randomly allotted to 5 treatment groups (4 pens per treatment with 18 pigs per pen) for a 28-day trial. Dietary treatments were basal diet without any antimicrobial (negative control; NC), basal diet supplemented with 120 mg/kg feed of neomycin sulfate (positive control; PC) and basal diet supplemented with 2×109 (L), 4×109 (M) and 20×109 (H) CFU/kg feed of B. subtilis KN-42. During the overall period, average daily gain and feed efficiency of piglets were higher in groups PC, M, and H than those in group NC (p<0.05), and all probiotics and antibiotics groups had a lower diarrhea index than group NC (p<0.05). The 16S rDNA gene-based methods were used to analyze faecal bacterial flora on day 28 of experiment. The result of denaturing gradient gel electrophoresis analysis showed that supplementation of B. subtilis KN-42 to the diet changed the bacterial communities, with a higher bacterial diversity and band number in group M than in the other four groups. Real-time polymerase chain reaction analysis showed that the relative number of Lactobacillus were higher in groups PC and H than in group NC (p<0.05), and the supplemented B. subtilis KN-42 to the diet also reduced the relative number of E. coli (p<0.05). These results suggest that dietary addition of B. subtilis KN-42 can improve the growth performance and gastrointestinal health of piglets. PMID:25083107

  13. Comparative genomic analysis of Geobacter sulfurreducens KN400, a strain with enhanced capacity for extracellular electron transfer and electricity production

    PubMed Central

    2012-01-01

    Background A new strain of Geobacter sulfurreducens, strain KN400, produces more electrical current in microbial fuel cells and reduces insoluble Fe(III) oxides much faster than the wildtype strain, PCA. The genome of KN400 was compared to wildtype with the goal of discovering how the network for extracellular electron transfer has changed and how these two strains evolved. Results Both genomes were re-annotated, resulting in 14 fewer genes (net) in the PCA genome; 28 fewer (net) in the KN400 genome; and ca. 400 gene start and stop sites moved. 96% of genes in KN400 had clear orthologs with conserved synteny in PCA. Most of the remaining genes were in regions of genomic mobility and were strain-specific or conserved in other Geobacteraceae, indicating that the changes occurred post-divergence. There were 27,270 single nucleotide polymorphisms (SNP) between the genomes. There was significant enrichment for SNP locations in non-coding or synonymous amino acid sites, indicating significant selective pressure since the divergence. 25% of orthologs had sequence differences, and this set was enriched in phosphorylation and ATP-dependent enzymes. Substantial sequence differences (at least 12 non-synonymous SNP/kb) were found in 3.6% of the orthologs, and this set was enriched in cytochromes and integral membrane proteins. Genes known to be involved in electron transport, those used in the metabolic cell model, and those that exhibit changes in expression during growth in microbial fuel cells were examined in detail. Conclusions The improvement in external electron transfer in the KN400 strain does not appear to be due to novel gene acquisition, but rather to changes in the common metabolic network. The increase in electron transfer rate and yield in KN400 may be due to changes in carbon flux towards oxidation pathways and to changes in ATP metabolism, both of which indicate that the overall energy state of the cell may be different. The electrically conductive pili appear

  14. Regional expression of the rice KN1-type homeobox gene family during embryo, shoot, and flower development.

    PubMed Central

    Sentoku, N; Sato, Y; Kurata, N; Ito, Y; Kitano, H; Matsuoka, M

    1999-01-01

    We report the isolation, sequence, and pattern of gene expression of members of the KNOTTED1 (KN1)-type class 1 homeobox gene family from rice. Phylogenetic analysis and mapping of the rice genome revealed that all of the rice homeobox genes that we have isolated have one or two direct homologs in maize. Of the homeobox genes that we tested, all exhibited expression in a restricted region of the embryo that defines the position at which the shoot apical meristem (SAM) would eventually develop, prior to visible organ formation. Several distinct spatial and temporal expression patterns were observed for the different genes in this region. After shoot formation, the expression patterns of these homeobox genes were variable in the region of the SAM. These results suggest that the rice KN1-type class 1 homeobox genes function cooperatively to establish the SAM before shoot formation and that after shoot formation, their functions differ. PMID:10488233

  15. Analyses of the MSLB benchmark V1000CT-2 by the coupled system code ATHLET-BIPR8KN

    SciTech Connect

    Nikonov, S. P.; Langenbuch, S.; Lizorkin, M. P.; Velkov, K.

    2006-07-01

    Within the activities of OECD/NEA is being initiated the second phase of the VVER-1000 Coolant Transient Benchmark (V1000CT-2). It considers the best estimate analyses of a Main Steam Line Break (MSLB) of a VVER-1000 NPP with two exercises. The analyses have been performed with the coupled system code ATHLET-BIPR8KN which enables to perform realistic simulation of three-dimensional neutron kinetics and thermal-hydraulic processes in VVER NPP. Results are presented and analysed for the two proposed scenarios. These results are supplemented by sensitivity studies varying the number of the thermo-hydraulic channels (THC) in the core and by comparisons with point kinetics calculations. This work is of considerable importance for the validation of the coupled system code ATHLET-BIPR8KN in case of asymmetric core inlet conditions. (authors)

  16. Advantages of using the Ate A 20 kN high performance storable propellant engine

    NASA Astrophysics Data System (ADS)

    Palmnas, Ulf; Hanneback, Thomas

    This paper tries with simple examples to point out the benefits of a turbopump fed storable engine/stage for low earth orbit (LEO) to geosynchronous transfer orbit/geosynchronous Earth orbit (GTO/GEO) missions. A comparison is made between pump/pressure fed storable, cryogenic, and solid stages. A table is also presented with mass benefits based on Ariane 5, Titan 4, H-II and a 'spaceplane' performance in LEO orbit. Volvo has studied such a turbopumpfed storable engine/stage called ATE (Advanced Technology Engine) with other European companies. The thrust of this engine is 20 kN and the ISP is 345 s. Volvos contribution has been on the engine system level as well as on design of the turbopump and nozzle. Typical applications for the ATE and similar engines (XLR-132) for an Orbit Transfer Vehicle (OPM, OTV) or for long duration scientific missions with large propulsion needs. For Europe, the ATE is also a possible choice for a new upper stage for the Ariane 5. If the ATE is used for LEO to GEO missions instead of pressurefed engine, the payload gain would be about 800 kg for both the Ariane 5 and Titan IV class. There is also a 20% returned mass increase for using the ATE for the scientific mission of returning a sample from a comet. The second part in this paper highlights the design of the ATE engine.

  17. Effects of Bacillus subtilis KN-42 on Growth Performance, Diarrhea and Faecal Bacterial Flora of Weaned Piglets.

    PubMed

    Hu, Yuanliang; Dun, Yaohao; Li, Shenao; Zhao, Shumiao; Peng, Nan; Liang, Yunxiang

    2014-08-01

    This research focused on the effects of different doses of Bacillus subtilis KN-42 on the growth performance, diarrhea incidence, faecal bacterial flora, and the relative number of Lactobacillus and Escherichia coli in faeces of weaned piglets to determine whether the strain can serve as a candidate antimicrobial growth promoter. A total of 360 piglets (initial body weight 7.14±0.63 kg) weaned at 26±2 days of age were randomly allotted to 5 treatment groups (4 pens per treatment with 18 pigs per pen) for a 28-day trial. Dietary treatments were basal diet without any antimicrobial (negative control; NC), basal diet supplemented with 120 mg/kg feed of neomycin sulfate (positive control; PC) and basal diet supplemented with 2×10(9) (L), 4×10(9) (M) and 20×10(9) (H) CFU/kg feed of B. subtilis KN-42. During the overall period, average daily gain and feed efficiency of piglets were higher in groups PC, M, and H than those in group NC (p<0.05), and all probiotics and antibiotics groups had a lower diarrhea index than group NC (p<0.05). The 16S rDNA gene-based methods were used to analyze faecal bacterial flora on day 28 of experiment. The result of denaturing gradient gel electrophoresis analysis showed that supplementation of B. subtilis KN-42 to the diet changed the bacterial communities, with a higher bacterial diversity and band number in group M than in the other four groups. Real-time polymerase chain reaction analysis showed that the relative number of Lactobacillus were higher in groups PC and H than in group NC (p<0.05), and the supplemented B. subtilis KN-42 to the diet also reduced the relative number of E. coli (p<0.05). These results suggest that dietary addition of B. subtilis KN-42 can improve the growth performance and gastrointestinal health of piglets.

  18. Fast Ion Effects on Fishbones and n=1 Kinks in JET Simulated by a Non-perturbative NOVA-KN Code

    SciTech Connect

    N.N. Gorelenkov; C.Z. Cheng; V.G. Kiptily; M.J. Mantsinen; S.E. Sharapov; the JET-EFDA Contributors

    2004-10-28

    New global non-perturbative hybrid code, NOVA-KN, and simulations of resonant type modes in JET [Joint European Torus] plasmas driven by energetic H-minority ions are presented. The NOVA-KN code employs the ideal-MHD description for the background plasma and treats non-perturbatively the fast particle kinetic response, which includes the fast ion finite orbit width (FOW) effect. In particular, the n = 1 fishbone mode, which is in precession drift resonance with fast ions, is studied. The NOVA-KN code is applied to model an n = 1 (f = 50-80kHz) MHD activity observed recently in JET low density plasma discharges with high fast ion (H-minority) energy content generated during the ion cyclotron resonance heating (ICRH). This n = 1 MHD activity is interpreted as the instability of the n = 1 precession drift frequency fishbone modes.

  19. Apport de la simulation numérique à la compréhension des mécanismes d'interaction de cavités dans le cadre de la modélisation de l'endommagement ductile sous sollicitation dynamique

    NASA Astrophysics Data System (ADS)

    Roy, G.; Buy, F.; Llorca, F.

    2002-12-01

    L'étude présentée s'inscrit dans le cadre d'une démarche menant à la construction d'un modèle analytique ou semi analytique de comportement élasto-visco-plastique endommageable, applicable aux chargements rencontrés en configuration d'impact violent et générant de l'écaillage ductile. La prise en compte des effets de compressibilité et de micro inertie est essentielle pour modéliser la phase de croissance. Des simulations numériques globales de la structure et locales à l'échelle des hétérogénéités permettent d'évaluer les niveaux de sollicitations dans les zones susceptibles de s'endommager, dévaluer des critères analytiques de germination de l'endommagement et de comprendre les mécanismes d'interaction entre les défauts. Les effets micro inertiels et de compressibilité sont ainsi mis en évidence dans les phases de germination et de coalescence des micro défauts. II s'agit ici d'une illustration non exhaustive de travaux engagés au CEA Valduc sur le tantale, dans le cadre d'une thèse [10]. Un programme matériaux en partenariat CEA-CNRS sur la modélisation multi échelles du comportement de structures a également été initié dans ce contexte.

  20. [Influences of pH and complexing agents on degradation of reactive brilliant blue KN-R by ferrous activated persulfate].

    PubMed

    Zhang, Cheng; Wan, Jin-Quan; Ma, Yong-Wen; Wang, Yan; Huang, Ming-Zhi; Lan, Ming

    2012-03-01

    The influences of pH and complexing agents on degradation of reactive brilliant blue KN-R by ferrous activated persulfate were investigated, and finally the complexed and the uncomplexed system were compared. Because the lower the pH the more quickly will be the dissociation of S2O8(2-) to the SO4(-*) and the ORP of the dominant radical SO4(-*) in the acidic condition is higher than the dominant radical *OH in the alkaline condition, KN-R degradation rates in acidic condition are far outweigh in the neutral and alkaline conditions. When pH value was 3, the residual rate of KN-R was 17.0% within 3 hours by EDTA system with the lowest PS consumption rate 32.3%, so EDTA was the best complexing agent choice in acidic condition. When pH value was 7, the residual rates of KN-R were 11.3%, 12.4% within 3 days by EDTA, citric acid system with the PS residual rates 28.9%, 28.0% respectively, so EDTA, citric acid were the better choices in the neutral condition. When pH value was 10, glucose acid, citric acid, EDTA and tartaric acid systems all had the similar KN-R degradation rates and PS residual rates, so all could acted as the complexing agents, when the system contained trace amounts of ferrous, the addition of complexing agent would greatly improve the degradation rate of pollutant, from original 52.5% to 79.3% of 3 d, so PS is suitable for in situ chemical oxidation (ISCO).

  1. A 2 Tesla Full Scale High Performance Periodic Permanent Magnet Model for Attractive (228 KN) and repulsive Maglev

    NASA Technical Reports Server (NTRS)

    Stekly, Z. J. J.; Gardner, C.; Domigan, P.; Baker, J.; Hass, M.; McDonald, C.; Wu, C.; Farrell, R. A.

    1996-01-01

    Two 214.5 cm. long high performance periodic (26 cm period) permanent magnet half-assemblies were designed and constructed for use as a wiggler using Nd-B-Fe and vanadium permendur as hard and soft magnetic materials by Field Effects, a division of Intermagnetics General Corporation. Placing these assemblies in a supporting structure with a 2.1 cm pole to pole separation resulted in a periodic field with a maximum value of 2.04 T. This is believed to be the highest field ever achieved by this type of device. The attractive force between the two 602 kg magnet assemblies is 228 kN, providing enough force for suspension of a 45,500 kg vehicle. If used in an attractive maglev system with an appropriate flat iron rail, one assembly will generate the same force with a gap of 1.05 cm leading to a lift to weight ratio of 38.6, not including the vehicle attachment structure. This permanent magnet compares well with superconducting systems which have lift to weight ratios in the range of 5 to 10. This paper describes the magnet assemblies and their measured magnetic performance. The measured magnetic field and resulting attractive magnetic force have a negative spring characteristic. Appropriate control coils are necessary to provide stable operation. The estimated performance of the assemblies in a stable repulsive mode, with eddy currents in a conducting guideway, is also discussed.

  2. A comparison of 200 kN magneto-rheological damper models for use in real-time hybrid simulation pretesting

    NASA Astrophysics Data System (ADS)

    Jiang, Z.; Christenson, R.

    2011-06-01

    Control devices can be used to dissipate the energy of a civil structure subjected to dynamic loading, such as earthquake, wave and wind excitation, thus reducing structural damage and preventing failure. The magneto-rheological (MR) fluid damper is a promising device for use in civil structures due to its mechanical simplicity, inherent stability, high dynamic range, large temperature operating range, robust performance, and low power requirements. The MR damper is intrinsically nonlinear and rate dependent. Thus a challenging aspect of applying this technology is the development of accurate models to describe the behavior of such dampers for control design and evaluation purposes. In particular, a new type of experimental testing called real-time hybrid simulation (RTHS) combines numerical simulation with laboratory testing of physical components. As with any laboratory testing, safety is of critical importance. For RTHS in particular the feedback and dynamic interaction of physical and numerical components can result in potentially unstable behavior. For safety purposes, it is desired to conduct pretest simulations where the physical specimen is replaced with an appropriate numerical model yet the numerical RTHS component is left unchanged. These pretest simulations require a MR damper model that can exhibit stability and convergence at larger fixed integration time steps, and provide computational efficiency, speed of calculation, and accuracy during pretest verification of the experimental setup. Several models for MR dampers have been proposed, including the hyperbolic tangent, Bouc-Wen, viscous plus Dahl and algebraic models. This paper examines the relative performance of four MR damper models of large-scale 200 kN MR dampers as needed for pretest simulations of RTHS. Experimental tests are conducted on two large-scale MR dampers located at two RTHS test facilities at the Smart Structures Technology Laboratory at the University of Illinois at Urbana

  3. Les Abondances Chimiques dans les Galaxies Spirales de Type Precoce

    NASA Astrophysics Data System (ADS)

    Dutil, Yvan

    1998-09-01

    Les galaxies spriales presentent une distribution continue de formes et de proprietes physiques. A l'heure actuelle, il existe deux ecoles de pensee au sujet de la nature de ces proprietes morphologiques des galaxies. Pour certains elles sont innees, pour d'autres elles sont acquises. Les gradients d'abondance nebulaires, de par leur sensibilite aux mouvements a grande echelle du gaz et au taux de formation stellaire, offrent une possibilite de trancher dans ce debat. Toutefois, jusqu'ici, on a surtout observe les gradients d'abondance dans les galaxies de type tardif. Le premier objectif de cette these est d'enrichir l'echantillon de galaxies de type precoce observees. Le second objectif est de demontrer qu'il y a deja eu une barre dans les galaxies de type precoce et, si possible, de chercher des traces d'interactions dans ces galaxies. Dans le cadre de cette these, j'ai observe huit galaxies de type precoce. Mes observations indiquent que ces galaxies presentent des profils d'abondance dont les caracteristiques se rapprochent des galaxies barrees, meme si certaines ne presentent pas de barres. Ce resultat renforce l'hypothese selon laquelle les galaxies changent de type morphologique au cours du temps sous l'effet d'instabilites comme les barres.

  4. The nucleoid-associated protein Dan organizes chromosomal DNA through rigid nucleoprotein filament formation in E. coli during anoxia

    PubMed Central

    Lim, Ci Ji; Lee, Sin Yi; Teramoto, Jun; Ishihama, Akira; Yan, Jie

    2013-01-01

    Dan is a transcription factor that regulates the ttd operon encoding tartrate dehydratase. During anaerobic conditions, its copy number increases by 100-fold, making Dan an abundant nucleoid-associated protein. However, little is known about the mode of Dan–DNA interaction. To understand its cellular functions, we used single-molecule manipulation and imaging techniques to show that Dan binds cooperatively along DNA, resulting in formation of a rigid periodic nucleoprotein filament that strongly restricts accessibility to DNA. Furthermore, in the presence of physiologic levels of magnesium, these filaments interact with each other to cause global DNA condensation. Overall, these results shed light on the architectural role of Dan in the compaction of Escherichia coli chromosomal DNA under anaerobic conditions. Formation of the nucleoprotein filament provides a basis in understanding how Dan may play roles in both chromosomal DNA protection and gene regulation. PMID:23180762

  5. NPPy With Dan DeVito

    NASA Video Gallery

    The NPP mission mascot NPPy was found by the NPP Ground Project Manager Dan DeVito in a place called Svalbard, located 600 miles from the North Pole. Since then, Dan and other people on the NPP pro...

  6. DAnCER: disease-annotated chromatin epigenetics resource.

    PubMed

    Turinsky, Andrei L; Turner, Brian; Borja, Rosanne C; Gleeson, James A; Heath, Michael; Pu, Shuye; Switzer, Thomas; Dong, Dong; Gong, Yunchen; On, Tuan; Xiong, Xuejian; Emili, Andrew; Greenblatt, Jack; Parkinson, John; Zhang, Zhaolei; Wodak, Shoshana J

    2011-01-01

    Chromatin modification (CM) is a set of epigenetic processes that govern many aspects of DNA replication, transcription and repair. CM is carried out by groups of physically interacting proteins, and their disruption has been linked to a number of complex human diseases. CM remains largely unexplored, however, especially in higher eukaryotes such as human. Here we present the DAnCER resource, which integrates information on genes with CM function from five model organisms, including human. Currently integrated are gene functional annotations, Pfam domain architecture, protein interaction networks and associated human diseases. Additional supporting evidence includes orthology relationships across organisms, membership in protein complexes, and information on protein 3D structure. These data are available for 962 experimentally confirmed and manually curated CM genes and for over 5000 genes with predicted CM function on the basis of orthology and domain composition. DAnCER allows visual explorations of the integrated data and flexible query capabilities using a variety of data filters. In particular, disease information and functional annotations are mapped onto the protein interaction networks, enabling the user to formulate new hypotheses on the function and disease associations of a given gene based on those of its interaction partners. DAnCER is freely available at http://wodaklab.org/dancer/.

  7. Inhibitory effects of KN-93, an inhibitor of Ca2+ calmodulin-dependent protein kinase II, on light-regulated root gravitropism in maize.

    PubMed

    Lu Y-T; Feldman, L J; Hidaka, H

    1993-01-01

    Light is essential for root gravitropism in Zea mays L., cultivar Merit. It is hypothesized that calcium mediates this light-regulated response. KN-93, an inhibitor of calcium/calmodulin kinase II (CaMK II), inhibits light-regulated root gravitropism but does not affect light perception. We hypothesize that CaMK II, or a homologue, operates late in the light/gravity signal transduction chain. Here we provide evidence suggesting a possible physiological involvement of CaMK II in root gravitropism in plants.

  8. Inhibitory effects of KN-93, an inhibitor of Ca2+ calmodulin-dependent protein kinase II, on light-regulated root gravitropism in maize

    NASA Technical Reports Server (NTRS)

    Feldman, L. J.; Hidaka, H.

    1993-01-01

    Light is essential for root gravitropism in Zea mays L., cultivar Merit. It is hypothesized that calcium mediates this light-regulated response. KN-93, an inhibitor of calcium/calmodulin kinase II (CaMK II), inhibits light-regulated root gravitropism but does not affect light perception. We hypothesize that CaMK II, or a homologue, operates late in the light/gravity signal transduction chain. Here we provide evidence suggesting a possible physiological involvement of CaMK II in root gravitropism in plants.

  9. Corner Office: Google's Dan Clancy

    ERIC Educational Resources Information Center

    Albanese, Andrew Richard; Oder, Norman

    2009-01-01

    This article presents an interview with Dan Clancy, engineering director for Google Book Search. In this interview, Clancy talks about the pending Google Book Search settlement, involving millions of volumes digitized from libraries, which drew a lawsuit from the Association of American Publishers and the Authors Guild. He also discusses pricing,…

  10. Site- and bond-percolation thresholds in Kn ,n-based lattices: Vulnerability of quantum annealers to random qubit and coupler failures on chimera topologies

    NASA Astrophysics Data System (ADS)

    Melchert, O.; Katzgraber, Helmut G.; Novotny, M. A.

    2016-04-01

    We estimate the critical thresholds of bond and site percolation on nonplanar, effectively two-dimensional graphs with chimeralike topology. The building blocks of these graphs are complete and symmetric bipartite subgraphs of size 2 n , referred to as Kn ,n graphs. For the numerical simulations we use an efficient union-find-based algorithm and employ a finite-size scaling analysis to obtain the critical properties for both bond and site percolation. We report the respective percolation thresholds for different sizes of the bipartite subgraph and verify that the associated universality class is that of standard two-dimensional percolation. For the canonical chimera graph used in the D-Wave Systems Inc. quantum annealer (n =4 ), we discuss device failure in terms of network vulnerability, i.e., we determine the critical fraction of qubits and couplers that can be absent due to random failures prior to losing large-scale connectivity throughout the device.

  11. Radiations cosmiques : danger dans l'Espace

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.; Dzitko, H.

    2000-06-01

    Au sol, l'atmosphere nous protege plus ou moins bien. Mais dans l'espace ou a bord des avions de ligne, l'homme est directement expose aux rayonnements cosmiques qui peuvent etre mortels. Un veritable frein a la presence humaine prolongee dans l'espace. Une menace que les agences spatiales prennent tres au serieux.

  12. Étude expérimentale de l'interaction laser-matière dans le cas du soudage d'un acier inoxydable austénitique par laser Nd:YAG continu de 2 kW

    NASA Astrophysics Data System (ADS)

    Dumord, E.; Jouvard, J. M.; Grevey, D.; Druetta, M.; Ottavi, P.

    1997-05-01

    The laser-matter interaction acting during cw 2 kW Nd:YAG laser welding of an austenitic stainless steel is studied and particulary the effects linked to the presence of a keyhole in the liquid bath. This is done in order to define parameters useful to the process modelling. The absorption factor of target has been measured in order to better understand the Nd:YAG laser/stainless steel 304 interaction. Then an experimental approach of the keyhole angle value determination is proposed. Values are presented showing the important keyhole angle at the bottom of the bead. Finally a study relative to the plume above the keyhole shows that it is responsible for the formation of the nail-head part, observed on the experimental melting zone, by laser beam scattering. L'interaction laser-matière se produisant lors du soudage par laser Nd:YAG continu de 2kW d'un acier inoxydable austénitique est étudiée, et notamment les effets liés à la présence du capillaire dans le bain liquide, de façon à définir les paramètres utiles à la modélisation du processus. Le facteur d'absorption des cibles utilisées a été mesuré afin de mieux appréhender l'interaction laser Nd:YAG/acier inoxydable austénitique 304. Puis une approche expérimentale de détermination de l'angle d'inclinaison du capillaire est proposée. Des valeurs sont présentées montrant la forte inclinaison du capillaire en fond de cordon. Finalement une étude relative au panache présent audessus du capillaire met en évidence qu'il est responsable de la formation de la partie en tête de clou observée sur les zones fondues expérimentales par diffusion du faisceau laser

  13. Caracterisation de la cohesion de l'interface AMF/polymere dans une structure deformable adaptative

    NASA Astrophysics Data System (ADS)

    Fischer-Rousseau, Charles

    réponse thermique transitoire du polymère et du fil d’AMF lors d’un chauffage par effet Joule est programmé à l’aide du logiciel ANSYS. Le comportement du modèle est validé avec des résultats expérimentaux où des thermocouples encastrés dans l’échantillon permettent des mesures locales de la température. Les résultats calculés sont en accord avec les résultats expérimentaux d’un point de vue qualitatif, mais accusent des différences significatives d’un point de vue quantitatif. La mesure du champ de déformation à l’interface du fil et du polymère dans une SDA permettrait de développer et valider un modèle numérique prenant en compte l’effet mémoire de forme d’un fil encastré dans une matrice polymère. Dans ce but, une machine de traction miniature permettant l’analyse par microspectrométrie Raman in situ est présentée. Elle a une capacité de 1 kN et un déplacement maximal de 20 mm dans une enveloppe de conception totale de 160 mm de diamètre. La machine est conçue pour que le milieu de l’échantillon soit immobile grâce au fait que le mouvement des deux extrémités soit symétrique. Les résultats montrent que du travail supplémentaire est nécessaire avant de pouvoir encastrer des fils d’AMF dans une structure déformable adaptative. Mots-clés: décohésion, structure active, alliage à mémoire de forme, AMF, tests d’arrachement.

  14. KNAP2, a class I KN1-like gene is a negative marker of bud growth potential in apple trees (Malus domestica [L.] Borkh.).

    PubMed

    Brunel, Nicole; Leduc, Nathalie; Poupard, Pascal; Simoneau, Philippe; Mauget, Jean-Claude; Viémont, Jean-Daniel

    2002-11-01

    The determinism of bud bursting pattern along the 1-year-old shoot was studied at the molecular and morphological levels in the apple tree variety 'Lodi' which shows an acrotonic tendency. At the molecular level, the expression of KNAP2, which belongs to the class I KN1-like gene family, was studied. Measurements were carried out during dormancy (October), breaking dormancy (January) and just before bud bursting (March). The results showed that KNAP2 is more highly expressed in buds that will remain at rest in the spring. Expression of KNAP2 was found in the meristem and in the marginal meristem of the two latest shaped primordia. In the January and March buds, this gene is also expressed in the procambial zone underneath the apical meristem. This study therefore suggests that KNAP2 may be considered as a negative marker of bud growth potential and that the growth inhibition in proximal buds could partially result from differential gene activity. At the morphological level, it was shown that no organogenetic activity took place between October and March as revealed by the constant number of leaf primordia in buds. Nevertheless, those buds likely to grow the following spring had a larger size and fewer hard scales than other buds. This suggests that genetic control may act together with other mechanisms, possibly physical (number of scales) or biochemical, to control bud inhibition.

  15. Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus.

    PubMed

    Kong, Fan-Dong; Ma, Qing-Yun; Huang, Sheng-Zhuo; Wang, Pei; Wang, Jun-Feng; Zhou, Li-Man; Yuan, Jing-Zhe; Dai, Hao-Fu; Zhao, You-Xing

    2017-02-17

    Six new meroterpenoids, chrodrimanins K-N (1-4), including two uncommon chlorinated ones (1 and 2), and verruculides B2 (5) and B3 (6), as well as seven known ones (7-13), were isolated from the fermentation broth of Penicillium sp. SCS-KFD09 isolated from a marine worm, Sipunculus nudus, from Haikou Bay, China. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data, X-ray diffraction analysis, and ECD spectra analysis along with quantum ECD calculations. In addition, the X-ray crystal structures and absolute configurations of two previously reported meroterpenoids, chrodrimanins F (9) and A (11), are described for the first time. Compounds 1, 4, and 7 displayed anti-H1N1 activity with IC50 values of 74, 58, and 34 μM, respectively, while compound 5 showed weak inhibitory activity against Staphylococcus aureus with an MIC of 32 μg/mL.

  16. The inhibitor of calcium/calmodulin-dependent protein kinase II KN93 attenuates bone cancer pain via inhibition of KIF17/NR2B trafficking in mice.

    PubMed

    Liu, Yue; Liang, Ying; Hou, Bailing; Liu, Ming; Yang, Xuli; Liu, Chenglong; Zhang, Juan; Zhang, Wei; Ma, Zhengliang; Gu, Xiaoping

    2014-09-01

    The N-methyl-d-aspartate receptor (NMDAR) containing subunit 2B (NR2B) is critical for the regulation of nociception in bone cancer pain, although the precise molecular mechanisms remain unclear. KIF17, a kinesin motor, plays a key role in the dendritic transport of NR2B. The up-regulation of NR2B and KIF17 transcription results from an increase in phosphorylated cAMP-response element-binding protein (CREB), which is activated by calcium/calmodulin-dependent protein kinase II (CaMKII). In this study, we hypothesized that CaMKII-mediated KIF17/NR2B trafficking may contribute to bone cancer pain. Osteosarcoma cells were implanted into the intramedullary space of the right femurs of C3H/HeJ mice to induce progressive bone cancer-related pain behaviors. The expression of spinal t-CaMKII, p-CaMKII, NR2B and KIF17 after inoculation was also evaluated. These results showed that inoculation of osteosarcoma cells induced progressive bone cancer pain and resulted in a significant up-regulation of p-CaMKII, NR2B and KIF17 expression after inoculation. Intrathecal administration of KN93, a CaMKII inhibitor, down-regulated these three proteins and attenuated bone cancer pain in a dose- and time-dependent manner. These findings indicated that CaMKII-mediated KIF17/NR2B trafficking may contribute to bone cancer pain, and inhibition of CaMKII may be a useful alternative or adjunct therapy for relieving cancer pain.

  17. Validation of High Aspect Ratio Cooling in a 89 kN (20,000 lb(sub f)) Thrust Combustion Chamber

    NASA Technical Reports Server (NTRS)

    Wadel, Mary F.; Meyer, Michael L.

    1996-01-01

    In order to validate the benefits of high aspect ratio cooling channels in a large scale rocket combustion chamber, a high pressure, 89 kN (20,000 lbf) thrust, contoured combustion chamber was tested in the NASA Lewis Research Center Rocket Engine Test Facility. The combustion chamber was tested at chamber pressures from 5.5 to 11.0 MPa (800-1600 psia). The propellants were gaseous hydrogen and liquid oxygen at a nominal mixture ratio of six, and liquid hydrogen was used as the coolant. The combustion chamber was extensively instrumented with 30 backside skin thermocouples, 9 coolant channel rib thermocouples, and 10 coolant channel pressure taps. A total of 29 thermal cycles, each with one second of steady state combustion, were completed on the chamber. For 25 thermal cycles, the coolant mass flow rate was equal to the fuel mass flow rate. During the remaining four thermal cycles, the coolant mass flow rate was progressively reduced by 5, 6, 11, and 20 percent. Computer analysis agreed with coolant channel rib thermocouples within an average of 9 percent and with coolant channel pressure drops within an average of 20 percent. Hot-gas-side wall temperatures of the chamber showed up to 25 percent reduction, in the throat region, over that of a conventionally cooled combustion chamber. Reducing coolant mass flow yielded a reduction of up to 27 percent of the coolant pressure drop from that of a full flow case, while still maintaining up to a 13 percent reduction in a hot-gas-side wall temperature from that of a conventionally cooled combustion chamber.

  18. A CHAT with Dan Johnson

    NASA Astrophysics Data System (ADS)

    Bertrand, Robert A.

    2003-04-01

    Dan's preoccupation with preventing NIHL is well known. For those of us who had the occasion to CHAT with him, we often heard him say ``if ears would bleed when exposed to noise, people would pay more attention to the harmful effect of noise upon hearing.'' His objective, as he often stated, was to eradicate NIHL so that in a few decades, it would become a historical footnote. Among his many preoccupations in his illustrious career, approaches and techniques to prevent NIHL were of primordial importance. One approach he advocated is the use of TTS instead of the STS in HCP's. His intention was to use the identification of TTS as an easy approach to introduce appropriate measures to prevent NIHL at a stage of reversibility rather than waiting for a confirmed permanent hearing loss, as noted with a confirmed STS. One of his last projects was developing the CHAT (Change of Hearing Audio Test) for easy use both in industrial and environmental settings to identify subjects with a TTS. Several groups are interested in pursuing his aim of using the TTS in HCP's, hoping to fulfill his comment that in a few decades, NIHL will become a historical footnote.

  19. Simultaneous Measurements of Neutron Environment at Mars from Orbit (Mars Odyssey HEND) and from the Surface (MSL DAN)

    NASA Astrophysics Data System (ADS)

    Martinez Sierra, L. M.; Jun, I.; Litvak, M. L.; Sanin, A. B.; Mitrofanov, I. G.

    2015-12-01

    Currently, the high energy neutron detector (HEND) onboard Mars Odyssey and the dynamic albedo of neutrons (DAN) instrument onboard the Mars Science Laboratory rover are simultaneously measuring the neutron environment from orbit and from the surface, respectively. Naturally-occurring neutrons at Mars are produced from the interactions of galactic cosmic rays (GCR) and solar energetic particles (SEP) with the Martian atmosphere and surface material. The neutron data from these simultaneous orbital and surface measurements are a good indicator for the state of general ambient radiation environments at Mars and can be also used as a means to infer how the ambient radiation is transported through the Martian atmosphere. Both HEND and DAN are healthy, and they provide the unique data sources valuable to study these phenomena for the period since the MSL landing in August 2012. Understanding of why there is correlation or no correlation between the two measurements will provide a key clue to understand the processes of GCR/SEP propagation through the Mars atmosphere and the interaction with the Mars surface materials. More detailed comparison between the two data sets and analysis of HEND/DAN data will be presented in the final presentation. Also, the long-term trend of the HEND/DAN data will be also compared with a general space weather condition. We used only publicly available HEND/DAN data in this study, e.g., open literature and/or planetary data system (PDS).

  20. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2008-06-01

    Les Antennes se rapprochent; Matière manquante; Galaxies trapues; Fusion de trous noirs; Thermomètre moléculaire; Supernova récente dans la Voie Lactée; Naine blanche particulière; L'étoile à neutrons 4U 1636-53; Pulsar étrange; Hubble; Fin du monde; Lunes; Extinction KT; L'axe changeant d'Europe; Ondes dans la haute atmosphère de Saturne; Anneau de Mars; Mars plus froid;

  1. Etude du champ magnetique dans les nuages moleculaires

    NASA Astrophysics Data System (ADS)

    Houde, Martin

    2001-12-01

    Ce travail est une étude du champ magnétique duns l'environnement circumstellaire des étoiles jeunes. Il a pour origine la certitude qu'avait l'auteur qu'il se devait d'être possible de détecter la présence d'un champ magnétique, et de possiblement le caractériser, par le biais d'observations de profils spectraux d'espèces moléculaires ioniques. Il en découle donc qu'un des buts principaux était de prouver que cela est effectivement possible. La thèse comporte alors des éléments théoriques et expérimentaux qui sont à la fois complémentaires et intimement liés. L'aspect théorique est basé sur l'interaction mutuelle que des particules neutres et chargées peuvent avoir l'une sur l'autre daps un plasma faiblement ionisé comme ceux existants daps les nuages moléculaires sites de formation stellaire. Il appert que la présence d'un champ magnétique a un effet direct sur le comportement des ions (via la force de Lorentz) et indirect sur les molécules neutres (via les nombreuses collisions entre les deux types de particules). Une telle interaction est, comme il est maintenant bien connu, présente dans les premières étapes de la formation dune étoile. Il s'agit bien sûr de la diffusion ambipolaire. Nous montrerons qu'il existe cependant un autre type de diffusion, jusqu'ici inconnue, qui se manifeste plus tard au tours de l'évolution des nuages moléculaires. Celle-ci peut avoir un effet dramatique sur l'apparence des profils spectraux (de rotation moléculaire) des espèces ioniques lorsque comparés à ceux qu'exhibent des espèces neutres coexistantes. Mais pour ce faire, il doit y avoir existence de mouvements organisés (des flots ou jets) de matière ou encore la présence de turbulence dans les régions considérées. Une distribution de vélocité du type maxwellienne ne révèlera pas la présence du champ magnétique. Les observations, qui ont pour but de confirmer la théorie, se situent dans le domaine des longueurs d

  2. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2010-03-01

    P/2010 A2 (LINEAR): astéroïde ou comète?; Astéroïdes au lavage; Trou noir stellaire lontain; Quasar double SDSS J1254+0846; Supernovae; Un nouveau regard sur Orion; Un petit berceau d'étoiles dans l'univers primitif; L'origine des galaxies spirales; Pluton; Spirit; NGC 6334

  3. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-12-01

    XMM à la recherche de la matière exotique; Ancienne étoile; Le Trou noir volant; Magnétar; Stardust et Annefrank; Le centre de la galaxie; Deux trous noirs dans la même galaxie; Eruption géante sur Io; Le Soleil;

  4. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2008-04-01

    Jets stellaires; Structure géante et matière noire; Un mini-système solaire; Arcs gravitationnels et images multiples; Choc frontal dans notre Galaxie; Avalanches martiennes; Du sable autour de KH 15D; Le cratère de Carancas; Smart-1;

  5. Dan Marino Helping Those with Autism Spectrum Disorders | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Marino Foundation. Photo: Dan Marino Foundation Former NFL star quarterback Dan Marino and his wife Claire experienced ... to succeed in life,'" says the former NFL star. "That's where the focus for The Dan Marino ...

  6. Modélisation de la combustion dans un moteur diesel d'automobile

    NASA Astrophysics Data System (ADS)

    Pinchon, Philippe

    La plupart des moteurs diesels utilisés pour la traction des véhicules automobiles sont des moteurs à préchambre. Le combustible y est introduit sous forme liquide, à haute pression, se vaporise, auto-inflamme et brûle dans un espace confiné dans lequel règnent des vitesses d'écoulement très élevées. La vitesse de combustion, et donc le rendement du moteur, sont très sensibles à divers paramètres liés à l'injection ou à la géométrie de la chambre. Cette dernière joue un rôle prédominant sur l'aérodynamique interne et son interaction avec la propagation de la flamme.

  7. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2003-09-01

    Système solaire poussiéreux; Combien d'étoiles dans le ciel?; Distance d'un pulsar; Planètes poussières et métaux; Un amateur belge bat les professionnels; Matière sombre; Supernova asymétrique; Anneau liégeois; Amas globulaires; Amas globulaires vagabonds; Baptême de satellites; Champ de gravité terrestre; Début de l'univers; XMM et Geminga; Carte neutrinos du ciel; Galaxies et trous noirs; Univers X; SMART-1: signal de départ pour l'aventure lunaire; Les saisons de Pluton; Planète dans M4; Rotation des pulsars; Un jumeau de Jupiter?; Le satellite ISO; Mars Express~:dernier clin d'oeil à la Terre; Waterworld: une réalité?

  8. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2004-11-01

    EF Eridani; Du sucre dans l'espace; Miras à la baisse; Eau et méthane sur Mars; Toutatis à l'ESO; SMART-1; Pollution globale; L'univers en 3D : symposium Gaia à Paris; Découverte du plus grand champ de cratères de météorites sur Terre; Cratère mystérieux; Minimum solaire

  9. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2005-03-01

    Trou noir glouton, Matière noire, Integral et le centre de notre Galaxie, Essaim de trous noirs, Carrousel autour de trous noirs, Érosion de trous noirs, Un quasar dans NGC 7319?, Distance de T Tauri, Chai non manquant, Des planètes autour d'une naine brune?, Titan, Une quatrième planète pour le pulsar PSR B1257+12, Smart 1, Aurores de Saturne

  10. Étude des modifications structurales de l'eau confinée dans le gel de silice

    NASA Astrophysics Data System (ADS)

    Fouzri, A.; Dorbez-Sridi, R.; Oumezzine, M.

    2004-11-01

    Les modifications structurales de l'eau confinée dans le gel de silice en poudre en fonction du taux d'hydratation sont étudiées par calorimétrie différentielle à balayage et par diffusion des rayons X. L'analyse thermique par DSC a permis de montrer que pour les faibles taux d'hydratation (≤ 50%) l'eau est complètement confinée dans les pores alors que pour les forts taux d'hydratation (>50%) l'eau se trouve aussi bien dans les pores qu'autour des grains de la silice. L'apparition de la glace cubique lors du refroidissement de l'eau confinée dans le gel de silice prouve que l'interaction eau-silice ne peut être négligée lors de la détermination du signal de l'eau. L'extraction du signal, diffusé uniquement par l'eau confinée, à partir des intensités diffusées par le gel de silice à deux taux d'hydratation distincts, révèle dans les fonctions de corrélation de paire un pic à 3.7Å qui ne peut être attribué qu'à une corrélation oxygène-oxygène inexistante dans l'eau massique et résultant de la déformation du réseau tétraédrique des molécules d'eau sous l'effet du confinement et de la proximité d'une surface.

  11. Manipulation coherente de qubits de spin dans une boite quantique triple

    NASA Astrophysics Data System (ADS)

    Gaudreau, Louis

    Nous presentons dans cette these une etude detaillee du moment magnetique intrinseque de l'electron, i.e. le spin electronique, incluant la manipulation quantique coherente des etats de spin de trois electrons couples. A cette fin, nous utilisons des boites quantiques laterales pour confiner les electrons. Ces nano-structures, d'une grandeur autour de 1 pm, permettent de confiner un nombre precis d'electrons de facon controlee, allant jusqu'a zero electrons. Les developpements technologiques et d'ingeniosite durant la derniere decennie ont permis de coupler trois boites quantiques, ainsi l'interaction entre plusieurs electrons confines peut etre controlee comme par exemple le couplage quantique tunnel et l'interaction d'echange entre les spins de chacun d'entre eux. A l'aide de boites quantiques couplees, il est possible de realiser des experiences dans plusieurs domaines de la physique moderne : les etats up et down du spin des electrons confines peuvent etre utilisees comme etats quantiques binaires (qubits) dans le domaine de l'informatique quantique, la non-localite quantique peut etre testee en separant spatialement deux electrons enchevetres, il est possible de creer des 'courants de spin enchevetres' utiles en spintronique, et bien d'autres. La manipulation coherente des etats de spin du systeme a trois electrons se fait de facon purement electrique grace a des pulses a haute frequence qui permettent d'augmenter le couplage entre les electrons et de faire la mesure de l'etat resultant apres la manipulation. Nous utilisons l'interaction hyperfine entre les spins des electrons et ceux des noyaux du cristal dans lequel ils resident pour creer les rotations quantiques entre les etats, notamment les etats |Q +3/2> et (D+1/2>. Les resultats obtenus indiquent un temps de coherence de l'ordre de 10 ns. Ces experiences demontrent un niveau de controle sans precedant de boites quantiques triples et pavent la voie vers des nano-structures plus sophistiquees dans

  12. Modelisation de la synthese reactive de poudres ultrafines dans un reacteur a plasma thermique

    NASA Astrophysics Data System (ADS)

    Desilets, Martin

    La presente these s'inscrit dans le cadre de la modelisation mathematique des ecoulements a plasmas thermiques inertes et reactifs. Elle vise plus precisement a combler les lacunes des modeles existants en portant une attention particuliere aux phenomenes de transport multicomposant et a la prediction des transformations chimiques. Pour repondre a ces attentes et ainsi poursuivre le developpement dans ce domaine, un modele global a ete developpe. Il combine la resolution d'equations conservatives pour la masse, l'energie et le momentum. La generation d'un plasma inductif (h.f ) y est traitee au moyen d'equations representant les champs electromagnetiques. La nucleation et la croissance de poudres ultrafines sont incluses dans le modele via l'analyse des principaux moments de la distribution des tailles de particules. Enfin, tous les phenomenes physico-chimiques d'importance dans un milieu comme les plasmas thermiques, de meme que lem interactions, sont consideres. Le modele est applique ici a l'analyse de trois problematiques differentes et complementaires. La premiere concerne l'etude du melange gazeux d'un jet froid (He, N 2 ou O2), injecte au coeur d'une decharge d'argon/hydrogene ou d'argon/oxygene. La comparaison des predictions du modele avec des mesures experimentales obtenues par une sonde enthalpique permet une validation partielle de ce dernier. La deuxieme problematique a trait a l'etude numerique de la pyrolyse du methane en reacteur a plasma h.f. Elle met en evidence les difficultes de convergence de la methode numerique lorsque appliquee a la resolution d'ecoulements reactifs a haute temperature. Finalement, le dernier sujet aborde dans cette these, soit l'analyse systematique des principales conditions d'operation d'un reacteur h.f utilise pour la synthese reactive de poudres ultrafines de silicium, engage tous les elements theoriques du modele. Il implique en effet la decomposition thermique d'un precurseur gazeux, le tetrachlorure de silicium, la

  13. 8. Wabash Ave. North. View of Loop and Dan Ryan ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Wabash Ave. North. View of Loop and Dan Ryan Line. Curve at Van Buren St. and Wabash Ave. at center. Dan Ryan line starts at center and runs south (toward bottom of picture). Photo by Jet Lowe. - Union Elevated Railroad, Union Loop, Wells, Van Buren, Lake Streets & Wabash Avenue, Chicago, Cook County, IL

  14. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2014-06-01

    Future lune ? - L'âge de la Lune - Des volcans actifs sur Vénus - Un lac dans le cratère Gusev ? - Météorites et atmosphère martiennes - L’hexagone de Saturne - Pluton - Exo-Terre - Bêta Pictoris b - Cérès et Vesta depuis Mars - Naine froide - Parallaxes par Hubble - L2 Puppis et le sort du Soleil - Supernova et lentille gravitationnelle - Champ magnétique galactique - L’objet de Sakurai - Fermi et la matière noire - Lentille naine

  15. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2013-12-01

    ISON; (3200) Phaéton; Titan, lacs et hydrocarbures; Titan et le Soleil; Jets; z8_GND_5296; La nébuleuse de la Crevette; Planète isolée; Nébuleuse Toby Jug; Le pulsar du Crabe; Le bulbe de la Voie lactée; ALMA au grand complet; APEX, ArTéMiS; Sgr A*; Première détection de l’acétate de méthyle dans l’espace

  16. STS-105 Crew Interview: Dan Barry

    NASA Technical Reports Server (NTRS)

    2001-01-01

    STS-105 Mission Specialist Dan Barry is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, training for the mission, and his role in the mission's activities. He gives details on the mission's goals, which include the transfer of supplies from the Discovery Orbiter to the International Space Station (ISS) and the change-over of the Expedition 2 and Expedition 3 crews (the resident crews of ISS). Barry discusses the importance of the ISS in the future of human spaceflight.

  17. Expedition 4 Crew Interviews: Dan Bursch

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Expedition 4 Flight Engineer Dan Bursch is seen during a prelaunch interview. He gives details on the mission's goals and significance, his role in the mission, what his responsibilities will be, what the crew exchange will be like (transferring the Expedition 4 crew in place of the Expedition 3 crew on the International Space Station (ISS)), the day-to-day life on an extended stay mission, the experiments he will be conducting on board, and what the S0 truss will mean to ISS. Bursch ends with his thoughts on the short-term and long-term future of the International Space Station.

  18. Long-term Passive Mode Data Measured by the Dynamic Albedo of Neutrons (DAN) Instrument onboard Mars Science Laboratory (MSL) and Comparison to REMS Surface Pressure and Temperature Measurements

    NASA Astrophysics Data System (ADS)

    Jun, I.; Mitrofanov, I. G.; Litvak, M. L.; Sanin, A. B.; Martín-Torres, J.; Zorzano, M. P.; Boynton, W. V.; Fedosov, F.; Golovin, D.; Hardgrove, C. J.; Harshman, K.; Kozyrev, A.; Kuzmin, R.; Malakhov, A. V.; Mischna, M. A.; Moersch, J.; Mokrousov, M.; Nikiforov, S.; Tate, C. G.

    2014-12-01

    Since the landing in August 2012, DAN has provided a wealth of scientific data from the successful surface operation in both Active mode and Passive mode. While the main DAN science investigation so far has focused in estimating the contents of water-equivalent-hydrogen (WEH) and chlorine-equivalent-neutron-absorption in the surface, here we will provide/discuss low energy (less than about 1 keV) background neutron environment at the Martian surface as measured by DAN Passive mode operation. Passive mode measurements have been done on almost every sols with durations ranging from 1 hour to ~9 hour, covering different times of a day. Neutrons from the onboard power source Multi Mission Radioisotope Thermonuclear Generator (MMRTG) and induced by Galactic Cosmic Ray (GCR)/Solar Energetic Particles (SEP) interactions with the Martian atmosphere and the surface material contribute to the DAN passive data. An approach to separate out the respective contributions from the DAN total count rates was developed previously (Jun et al., 2013) using the data collected at Rocknest (where the rover stayed from sol 60 to sol 100). The main goal of this paper is to extend the same analysis to other locations encountered during the rover traverse especially to understand the long-term (through Sol 800, covering more than 1 Martian year) behavior of the neutron environment at the Martian surface as measured by DAN in response to variation of the free space GCR/SEP environment. Extensive Monte Carlo transport simulations using Monte Carlo N-Particle eXtended (MCNPX) have been performed to support the analysis and to aid interpretation of the DAN passive data. In addition, the DAN passive data are compared to the long-term surface temperature and pressure data (both measured and modeled) from Rover Environmental Monitoring Station (REMS) to investigate possible correlation of the DAN data with ambient environmental conditions.

  19. The effect of Danquah Communication System (DanCS) boards on maladaptive behaviours among individuals with severe intellectual impairment and non-verbal communication skills.

    PubMed

    Danquah, S A; Mate-Kole, C C; Zehr, R T

    1996-06-01

    There is evidence that some individuals with severe intellectual impairment who are non-verbal may, out of frustration, display such inappropriate behaviour as aggression and self-injury as a means of communicating their needs to caregivers. The purpose of this study was to develop an inexpensive augmented communication device and to teach individuals with multiple impairment to use this method to communicate their needs in order to reduce their aggressive behaviours. The Dan Communication System (DanCS) symbol boards were therefore designed with computerized voice interface to help the individuals communicate to caregivers by means of audio and visual signs. A working DanCS board has been successfully developed and can now be mass produced by a manufacturer. The DanCS board is illustrated and described. A measurement device called the Goal Attainment Scale (GAS) that focused on three target behaviours; pressing of symbols, control of aggression, and social interaction with caregivers, was used to evaluate progress in the participating subjects (N = 30). Results showed that the multiply impaired individuals in the study significantly improved in all the targeted behaviours through the use of the DanCS. Details of the study are reported.

  20. Etude des proprietes electroniques des etats fondamentaux aux facteurs de remplissage entiers dans la bicouche de graphene

    NASA Astrophysics Data System (ADS)

    Lemonde, Marc-Antoine

    Dans ce document, on etudie les proprietes electroniques d'un systeme compose de deux couches de graphene separees par un dielectrique en presence d'un fort champ magnetique perpendiculaire. L'epaisseur du dielectrique est choisie de facon a pouvoir negliger le transfert de charges par effet tunnel. Ce type de systeme est etudie par quelques groupes de recherche dans le principal but de predire et comprendre la formation de condensat de Bose-Einstein d'excitons dont les composants sont des fermions relativistes sans masse [1] [2] [3]. Nous nous interessons a l'effet de l'interaction electron-electron sur les etats fondamentaux de ce systeme et 'a leurs excitations collectives a facteur de remplissage entier. Plus precisement, nous etudions les diagrammes de phase de cette bicouche de graphene sans terme tunnel dans le niveau de Landau n = 0 pour les facteurs de remplissage nu = 1 et nu = 2 dans la limite ou la temperature tend vers zero. Lors de cette etude, nous appuyons les predictions faites par Allan H. MacDonald et Yogesh N. Joglekar a propos de la formation d'un condensat de Bose-Einstein d'excitons pour differentes zones des diagrammes de phase. Nous etudions aussi la relation de dispersion des excitations collectives soutenues par les etats fondamentaux et leur effet sur le systeme. Finalement, nous nous interessons a la conductivite du systeme. Nous demontrons alors les regles de selection pour l'absorption inter-niveaux de Landaux et nous etudions l'effet des modes collectifs sur l'absorption .intrarniveau de Landau, Ce dernier phenomene ressort directement de la forme particuliere du reseau atomique du graphene et nous proposons dans ce document une toute premiere etude de ce concept. Mots-cles : graphene, gaz d'electrons bidimensionnel, effets Hall quantiques, proprietes electroniques, modes collectifs

  1. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2009-10-01

    Dunes de Titan; Lac Ontario; Titan; Anneaux de Saturne; Jupiter; Mars; Rotation de Saturne; Valles Marineris; Méthane martien; Epsilon Aurigae; Glycine cométaire; HD 87643; Pluton; Bételgeuse; Site astronomique; Andromède cannibale; Attaque de trou noir; BD+44 493; Formation d'étoiles; Gaz manquant; LIGO; M87; Naine blanche; Galaxie satellite; Galaxies naines sphéroïdales; Galaxies trapues; Cygnus X-1; L'avenir de la Voie Lactée; Naphtaline cosmique; Premiers trous noirs; Coup de foudre; Effet de serre; Glace lunaire; Impacts et extinctions; Exoplanètes rétrogrades; Kepler; Planète chaude; Collision planétaire; Disques dans le vent; Exoplanètes; Formation des planètes; Taches et transits

  2. STS-108 Crew Interviews: Dan Tani

    NASA Technical Reports Server (NTRS)

    2001-01-01

    STS-108 Mission Specialist Dan Tani is seen during a prelaunch interview. He answers questions about the mission's goals and significance, explaining the meaning of 'utilization flight 1' (UF-1) as opposed to an 'assembly flight'. He gives details on the payload (Starshine Satellite, Avian Development Facility, and Rafaello Multipurpose Logistics Module (MPLM)), his role in the rendezvous, docking, and undocking of the Endeavour Orbiter to the International Space Station (ISS), how he will participate in the unloading and reloading of the MPLM, and the way in which the old and new resident crews of ISS will exchanged. Tani ends with his thoughts on the short-term and long-term future of the International Space Station.

  3. Pat Thiel talks about Nobel Prize winner Dan Shechtman

    SciTech Connect

    Thiel, Pat

    2012-01-01

    Ames Laboratory senior scientist and Iowa State University Distinguished Professor of Chemistry Pat Thiel talks about her friend and colleague Dan Shechtman who received the 2011 Nobel Prize for Chemistry.

  4. Pat Thiel talks about Nobel Prize winner Dan Shechtman

    ScienceCinema

    Thiel, Pat

    2016-07-12

    Ames Laboratory senior scientist and Iowa State University Distinguished Professor of Chemistry Pat Thiel talks about her friend and colleague Dan Shechtman who received the 2011 Nobel Prize for Chemistry.

  5. 15. View South on Wabash of Dan Ryan Line showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. View South on Wabash of Dan Ryan Line showing curve from Harrison St. Photo by Jet Lowe. - Union Elevated Railroad, Union Loop, Wells, Van Buren, Lake Streets & Wabash Avenue, Chicago, Cook County, IL

  6. 1. Historic American Buildings Survey Dan Leyrer, Photographer Summer 1964 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Dan Leyrer, Photographer Summer 1964 FRONT ELEVATION, OVERLOOKING BAYOU ST. JOHN - Michel-Pitot House, 1370 Moss Street (moved to 1440 Moss Street), New Orleans, Orleans Parish, LA

  7. Environmental Scientist/Chemist Dan Gazda Speaks With Students

    NASA Video Gallery

    From NASA's International Space Station Mission Control Center, Environmental Scientist/Chemist Dan Gazda participates in a Digital Learning Network (DLN) event with students at from St. Peter's Pr...

  8. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2007-09-01

    Anions interstellaires; S Orionis; Altaîr; Courants stellaires; Etoiles jeunes; 2MASSW J1207334-393254; Alpha Andromède; Etoiles à neutrons (1); LH54-425; AGNs invisibles; Deux supernovae; Les GRBs seon Swift; Peser les trous noirs; Formation de trous noirs; Trou noir; ondes gravitationnelles : Virgo entre dans sa phase d'exploitation scientifique; Amas de galaxies actifs; Amas de galaxies; Galaxies actives d'amas; L'univers statique: le retour; Macho; Exoplanètes; Exoplanètes habitables?; Exoplanètes habitables? (suite); Une année d'un an; Une année de 31 heures; Valse des Jupiters; Disque de HD 15115; Impact majeur; Planètes isolées; Super-Jupiter; Impact et mini-extinction; L'effet Pioneer; Toungouska; Spéléo martienne; Autres lunes dactives; Encelade; Hypérion; Pluton dépassé; Satellites d'Uranus; Titan

  9. Etude theorique des fluctuations structurales dans les composes organiques a dimensionnalite reduite

    NASA Astrophysics Data System (ADS)

    Dumoulin, Benoit

    'instabilite spin-Peierls apparait ensuite vers 60K. Notre etude theorique montre qu'un modele d'electrons en interaction de type "g-ologie" avec possibilite de processus umklapp permet de bien rendre compte des proprietes physiques de ce systeme. Finalement, la troisieme partie de cette these porte sur l'etude des premiers composes organiques quasi-unidimensionnels a avoir ete synthetises: les composes de la famille du TTF-TCNQ. Notre etude theorique des instabilites structurales que presentent ces composes n'est evidemment pas la premiere. L'originalite de cette derniere est qu'elle tient compte des fortes interactions entre les electrons, presentent dans ces composes. Pour tenir compte de telles interactions, nous avons choisi la formulation "liquide de Luttinger" qui nous permet de mieux traiter ce regimne dit de couplage fort.

  10. [Systematic evaluation of clinical application of Dingkun Dan].

    PubMed

    Chen, Yan-xia; Ma, Kun

    2015-10-01

    Dingkun Dan is a representative of the classic gynecological medicine. With Tonifying the liver and kidney, supplementing Qi and nourishing blood, regulating menstruation Shuyu, promoting the role of pain. Used in treatment of liver and kidney deficiency, deficiency of both qi and blood, Qi stagnation and blood stasis caused by irregular menstruation, menstrual pain, uterine bleeding, leukorrhea with reddish discharge, bruise blood removal, infertility, and various postpartum deficiency and bone steaming hot flashes of gynecological common disease. In recent years, Dingkun Dan's new uses have been reported, the clinical application value is worth further digging. In this paper, clinical application and research progress of Dingkun Dan since the founding of new China were briefly discussed, and summarize for the randomized controlled trials.

  11. Pair interaction lattice gas simulations: Flow past obstacles in two and three dimensions

    SciTech Connect

    Vogeler, A.; Wolf-Gladrow, D.A. )

    1993-04-01

    Apart from the FCHC (face-centered hypercube), Nasilowski's pair interaction lattice gas (PI) is the only known lattice gas automaton for three-dimensional hydrodynamic simulations. Unfortunately, the viscosity of PI is not isotropic. In order to determine the degree anisotropy, the authors derive fluid dynamic equations for the regime of compressible viscid flow. From relaxation measurements of waves propagating in various directions they compute the physically relevant dissipation coefficients and compare their results with theoretical predictions. Although PI shows a high degree of anisotropy, they define the mean value of the dissipation tensor as effective shear viscosity. Using this value of v[sub eff][sup 2D] = 0.35, two-dimensional simulations of flow past a cylinder yield drag coefficients in quantitative agreement with wind tunnel measurements over a range of Reynolds numbers of 5-50. Three-dimensional simulations of flow past a sphere yield qualitative agreement with various references. A fit of the results to a semi-empirical curve provides an effective value of v[sub eff][sup 2D] = 0.21 for a range of Reynolds numbers from 0.19 to 40. In order to check for finite-size effects, the authors measured the mean free path [lambda] and computed the Knudsen numbers. They obtained [lambda] [approx]1 lattice unit, corresponding to Kn = 0.01 (2D) and Kn = 0.1 (3D). They found no significant finite-size effects. 44 refs., 10 figs.

  12. L’apport de la dermoscopie dans le carcinome basosquameux

    PubMed Central

    Elmahi, Hakima; Lahlou, Asmae; Baybay, Hanane; Gallouj, Salim; Mernissi, Fatima Zahra; Reggad, Fatima Zahra; Harmouch, Taoufik

    2016-01-01

    Le carcinome basosquameux (CBS) est un cancer cutané rare qui présente des zones de carcinome basocellulaire (CBC) et de carcinome épidermoïde (SCC) et une zone de transition entre elles. Cependant, les caractéristiques dermoscopiques du BSC ne sont pas bien décrites dans la littérature, sauf deux études. Le but du présent cas était de mieux identifier et clarifier la contribution de la dermoscopie dans le diagnostic du BSC, malgré que la confirmation reste toujours histologique. PMID:28293368

  13. Decavanadate, a P2X receptor antagonist, and its use to study ligand interactions with P2X7 receptors.

    PubMed

    Michel, Anton D; Xing, Mengle; Thompson, Kyla M; Jones, Clare A; Humphrey, Patrick P A

    2006-03-18

    In this study we have studied decavanadate effects at P2X receptors. Decavanadate competitively blocked 2'- and 3'-O-(4benzoylbenzoyl) ATP (BzATP) stimulated ethidium accumulation in HEK293 cells expressing human recombinant P2X7 receptors (pK(B) 7.5). The effects of decavanadate were rapid (minutes) in both onset and offset and contrasted with the much slower kinetics of pyridoxal 5-phosphate (P5P), Coomassie brilliant blue (CBB) and 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN62). Decavanadate competitively blocked the slowly reversible, or irreversible, blockade of the P2X7 receptor produced by P5P and oxidised ATP suggesting competition for a common binding site. However, the interaction between decavanadate and KN62 was non-competitive. Decavanadate also blocked P2X2 and P2X4 receptors but with slightly lower potency. These data demonstrate that decavanadate is the first reversible and competitive antagonist of the P2X7 receptor and is a useful tool for studying the mechanism of interaction of ligands with the P2X7 receptor.

  14. La distribution radiale de L'UO 2 dans la phase vitreuse dans des crayons D'UO 2-SiO 2 obtenus par injection dans des moules de cuivre

    NASA Astrophysics Data System (ADS)

    Goran, Maria

    1980-11-01

    Une méthode d'analyse rationnelle a été mise au point qui doit permettre de déterminer la quantité de phase cristalline UO 2 dans les masses vitrocéramiques et la variation de cette quantité en fonction de la distance á la surface de l'échantillon. Cette méthode a été utilisée pour déterminer la distribution radiale de l'UO 2 dans la phase vitreuse dans des aiguilles d'UO 2-SiO 2 obtenus par injection dans des moules de cuivre. La teneur en d'UO 2 dans la phase vitreuse présente une variation très importante dans une couche périphérique de l'échantillon de 60 μm d'épaisseur environ; la valeur moyenne dans cette couche dépasse d'un ordre de grandeur la valeur moyenne dans tout la section. Cette région correspond á une vitesse de refroidissement qui dépasse 10 6°C/s.

  15. Transport de paires EPR dans des structures mesoscopiques

    NASA Astrophysics Data System (ADS)

    Dupont, Emilie

    Dans cette these, nous nous sommes particulierement interesses a la propagation de paires EPR1 delocalisees et localisees, et a l'influence d'un supraconducteur sur le transport de ces paires. Apres une introduction de cette etude, ainsi que du cadre scientifique qu'est l'informatique quantique dans lequel elle s'inscrit, nous allons dans le chapitre 1 faire un rappel sur le systeme constitue de deux points quantiques normaux entoures de deux fils supraconducteurs. Cela nous permettra d'introduire une methode de calcul qui sera reutilisee par la suite, et de trouver egalement le courant Josephson produit par ce systeme transforme en SQUID-dc par l'ajout d'une jonction auxiliaire. Le SQUID permet de mesurer l'etat de spin (singulet ou triplet), et peut etre forme a partir d'autres systemes que nous etudierons ensuite. Dans le chapitre 2, nous rappellerons l'etude detaillee d'un intricateur d'Andreev faite par un groupe de Bale. La matrice T, permettant d'obtenir le courant dans les cas ou les electrons sont separes spatialement ou non, sera etudiee en detail afin d'en faire usage au chapitre suivant. Le chapitre 3 est consacre a l'etude de l'influence du bruit sur le fonctionnement de l'intricateur d'Andreev. Ce bruit modifie la forme du courant jusqu'a aboutir a d'autres conditions de fonctionnement de l'intricateur. En effet, le bruit present sur les points quantiques peut perturber le transport des paires EPR par l'intermediaire des degres de liberte. Nous montrerons que, du fait de l'"intrication" entre la charge de la paire et le bruit, la paire est detruite pour des temps longs. Cependant, le resultat le plus important sera que le bruit perturbe plus le transport des paires delocalisees, qui implique une resonance de Breit-Wigner a deux particules. Le transport parasite n'implique pour sa part qu'une resonance de Breit-Wigner a une particule. Dans le chapitre 4, nous reviendrons au systeme constitue de deux points quantiques entoures de deux fils

  16. "Shawthan Dan," "Shawthan Kwanje": Good People, Good Words--Creating a "dan k'e" Speech Community in an Elementary School

    ERIC Educational Resources Information Center

    Ferguson, Jenanne

    2010-01-01

    This paper investigates how the processes of language transmission among speakers of Southern Tutchone ("dan k'e"), an indigenous Athapaskan language of the southern Yukon Territory, Canada, bear out an emerging theoretical interest in how bottom-up communicative practices shape language policy. An examination of "dan k'e"…

  17. Transport de particules massives dans un fluide turbulent: Application a l'erosion due au sable sur les parois d'une turbine hydraulique

    NASA Astrophysics Data System (ADS)

    Bergeron, Stephen

    Le transport de particules massives par un champ turbulent est un vaste domaine de la mécanique des fluides. Il possède de nombreuses applications comme par exemple le transport de sable dans une turbine hydraulique. En raison de la dureté des grains de quartz et des grandes vitesses de collision avec les parois métalliques, un phénomène d'érosion intensif se produit. Les dommages résultants peuvent diminuer le rendement de la turbine au cours des quelques mois suivant la mise en opération. L'objectif de cette thèse est de mettre au point un outil permettant de prédire ces zones d'érosion. Ce projet de recherche en contexte industriel a été réalisé en collaboration avec la compagnie General Electric Hydro du Canada. Dans un régime hautement turbulent, il est possible d'obtenir une expression suffisamment générale en utilisant une formulation partiellement empirique: l'équation de Basset- Boussinesq-Oseen modifiée. Ce choix de modèle tient compte du niveau de précision recherché et de la méthode numérique employée afin de résoudre la phase fluide. Il permet aussi d'éliminer plusieurs ambiguïtés fréquemment rencontrées dans la littérature et implementées dans certains codes commerciaux courants. La formulation mathématique du problème est effectuée dans un espace mixte Euler-Lagrange. Les paramètres dynamiques sont relies au type de particules et à l'intensité de la turbulence. Le code numérique résultant est le plus performant développé à ce jour (août 1998). Les trajectoires de plusieurs centaines de milliers de particules peuvent être simulées et visualisées de manière interactive sur une station de travail (SGI R4K, R8K et R10K). L'utilisateur du logiciel est libre de se déplacer dans l'espace à l'aide d'un environnement similaire a un ``simulateur de vol''. Il peut ainsi analyser les détails du processus d'érosion de même que l'écoulement du fluide dans la turbine. Les zones d'érosion obtenues à l

  18. Transport et bruit quantique dans les fils mésoscopiques

    NASA Astrophysics Data System (ADS)

    Torrès, J.

    2002-01-01

    Un conducteur quantique est bien caractérisé par sa conductance donnée par la formule de Landauer. Mais le bruit contient davantage d'informations que la conductance : il mesure les fluctuations temporelles du courant autour de sa valeur moyenne. De plus, le signe des corrélations de bruit est lié à la statistique des porteurs de charge. Dans une jonction entre un métal normal et un supraconducteur, le bruit présente une singularité à la fréquence Josephson, signature de la charge 2e des paires de Cooper impliquées dans le transport. Lorsque la tension appliquée est supérieure au gap du supraconducteur, la courbe du bruit exhibe des singularités à plusieurs fréquences auxquelles on peut associer un processus de réflexion ou de transmission. L'analogue fermionique de l'expérience d'Hanbury-Brown et Twiss avec un supraconducteur permet d'observer à la fois des corrélations positives et négatives dans un même système. Maintenir une différence de potentiel entre les deux extrémités d'un fil crée une situation relevant de la thermodynamique hors de l'équilibre. Formellement, on peut se ramener à un calcul à l'équilibre et écrire une théorie des perturbations grâce à la méthode de Keldysh. La théorie des liquides de Luttinger décrit les systèmes unidimensionnels d'électrons en interaction. Le hamiltonien peut se mettre sous forme quadratique grâce à la bosonisation. D'autre part, un liquide de Luttinger chiral constitue un bon modèle des états de bord de l'effet Hall quantique fractionnaire. Grâce au formalisme de Keldysh, on peut retrouver une formule de type Schottky et identifier la charge des quasiparticules de Laughlin.

  19. [Academic thinking on Cheng Dan-an's theory of acupuncture].

    PubMed

    Zhang, Shu-jian

    2011-11-01

    Academic thinking on Cheng Dan-an's theory of acupuncture is analyzed. It is stated that Cheng's theory of acupuncture has put exceptional emphasis and efforts on inheriting the tradition and learning from the west by pursuing truth. He concisely reinterpretes the traditional theory of acupuncture and practically improves the acupuncture instruments according to clinical experiences. Meanwhile, he introduces the advanced achievements of anatomy and neurophysiology into acupuncture teaching and research, which plays an important role for modernization of acupuncture.

  20. NASA Administrator Dan Goldin talks with STS-78 crew

    NASA Technical Reports Server (NTRS)

    1996-01-01

    NASA Administrator Dan Goldin (left) chats with STS-78 Mission Commander Terence 'Tom' Henricks (center) and KSC Director Jay Honeycutt underneath the orbiter Columbia. Columbia and her seven-member crew touched down on Runway 33 of KSC's Shuttle Landing Facility at 8:36 a.m. EDT, July 7, bringing to a close the longest Shuttle flight to date. STS-78, which also was the 78th Shuttle flight, lasted 16 days, 21 minutes and 47 seconds.

  1. Interaction between Shock Wave and Boundary Layer in Nonequilibrium Hypersonic Rarefied Flow

    NASA Astrophysics Data System (ADS)

    Tsuboi, Nobuyuki; Matsumoto, Yoichiro

    An experimental study of the interaction between a shock wave and a boundary layer over a flat plate with a sharp leading edge in hypersonic rarefied gas flow is presented. Experiments in a low-density wind tunnel using an electron beam probe were conducted at the Shock Wave Laboratory, RWTH Aachen, Germany. Rotational temperatures for stagnation temperatures of T0=670˜1000 K and Kn=0.024˜0.028 based on a reference length of 0.05m were calculated using Muntz’s method and Robben and Talbot’s method. The domain of quasi two-dimensional flow over the plate was determined from three-dimensional rotational temperature measurements. Nonequilibrium between translational and rotational temperatures was observed near the leading edge, and the experimental rotational relaxation length explains the rotational collision number of 2˜4.

  2. Dissolution de la matiere lignocellulosique dans les liquides ioniques

    NASA Astrophysics Data System (ADS)

    Rebiere, Jeremy

    De nos jours, avec la raréfaction des ressources fossiles, le développement de procédés entrant dans le cadre de la chimie verte s'accentue. De plus, ces procédés utilisent comme ressources, des matériaux d'origine végétale, abondants et biodégradables. Au cours de ces 20 dernières années, la littérature utilisant les liquides ioniques (LI) connait une importante croissance. Ces solvants sont de plus en plus employés dans des réactions chimiques classiques. Cependant le coût de leur synthèse en fait un solvant réactionnel cher dont l'application en tant que tel dans l'industrie ne peut être raisonnablement envisagée. Ces liquides ioniques permettent la dissolution des matériaux lignocellulosiques (lignine ou cellulose) et possèdent des propriétés physico-chimiques intéressantes. Nous savons également que la dissolution de la cellulose par des procédés d'hydrolyse classique s'effectue dans des conditions dures, dues à la structure cristalline de la cellulose, (fortes concentrations en acide) qui paraissent limitées pour une utilisation à grande échelle. Il est donc nécessaire de rechercher des méthodes moins onéreuses et plus efficaces écologiquement. S'appuyant sur des recherches démontrant que la dissolution de la cellulose dans les LI, diminue la cristallinité de la cellulose, nous allons chercher à démontrer au cours de ces travaux, la possibilité d'utiliser les LI comme moyen de prétraitement pour la dissolution de la cellulose. Nous allons nous attacher à dissoudre la cellulose, et à étudier les proportions pouvant être dissoutes. Puis nous chercherons à récupérer puis à réutiliser ces LI. Enfin nous cherchons à caractériser les modifications apportées à notre cellulose. Mots Clés liquide ionique, cellulose, cristallinité, réactivité, dissolution, régénération, non-solvant, purification, prétraitement, zone amorphe.

  3. Coherent beam-beam interaction with four colliding beams

    NASA Astrophysics Data System (ADS)

    Podobedov, B.; Siemann, R. H.

    1995-09-01

    The coherent beam-beam interaction in the absence of Landau damping is studied with a computer simulation of four space-charge-compensated colliding beams. Results are presented for the modes, phase space structures, widths, and growth rates of coherent beam-beam resonances. These results are compared with solutions of the Vlasov equation, and with measurements made at the Dispositif de Collisions dans l'Igloo (DCI) storage ring in Orsay, France, which operated with space-charge-compensated colliding beams.

  4. Inhomogeneites dans le Vent des Etoiles Wolf-Rayet

    NASA Astrophysics Data System (ADS)

    Robert, Carmelle

    1992-01-01

    Des mesures spectroscopiques effectuees avec un haut rapport signal sur bruit et une bonne resolution ont demontre l'existence de regions perturbees en mouvement dans le vent d'etoiles Wolf-Rayet (WR). L'echantillon d'objets etudies ici comprend 9 etoiles WR couvrant differents sous-types WN et WC. De nombreuses petites structures variables superposees au profil des raies d'emission formees dans le vent stellaire signalent la presence des perturbations. L'etude des variations globales des raies et l'examen des micro-structures individuelles ont permis de decrire plusieurs caracteristiques des perturbations. Entre autres, on observe des correlations significatives entre le niveau de variabilite des raies et certains parametres des etoiles qui confirment que le phenomene de variabilite est intrinseque au vent stellaire. En comparant les changements des vitesses radiales et des largeurs equivalentes des differentes raies d'une meme etoile, on conclut que les regions perturbees ont une etendue finie par rapport a l'enveloppe des etoiles. On peut facilement suivre les structures individuelles sur une periode de temps couvrant ~eq8 heures (et peut etre meme 24 heures) avant qu'elles ne disparaissent. Durant ce temps les structures se deplacent en s'eloignant du centre de la raie. A partir des differents comportements notes lors de l'analyse des variations globales et lors de l'examen des structures individuelles, on propose de representer les perturbations par un modele d'inhomogeneites discretes en expansion dans le vent. On suppose simplement que les inhomogeneites emettent comme le vent global (et absorbent aussi si le vent global montre un profil P Cyg). La superposition du graphique de l'acceleration radiale moyenne des inhomogeneites de WR140 en fonction de leur vitesse radiale et du modele theorique d'inhomogeneites qui suivent la loi generale de vitesse donne un taux d'acceleration lent, avec beta >= 3 pour les inhomogeneites de cette etoile. On obtient, entre

  5. 77 FR 75628 - STS Hydropower, Ltd., Dan River, Inc., and City of Danville, VA; Notice of Application for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... Energy Regulatory Commission STS Hydropower, Ltd., Dan River, Inc., and City of Danville, VA; Notice of..., 2012, Jeoffrey L. Burtch, as Chapter 7 Bankruptcy Trustee for Dan River, Inc. and STS Hydropower, Ltd... the license for the Schoolfield Hydroelectric Project from Dan River, Inc. and STS Hydropower, Ltd....

  6. The Dynamic Albedo of Neutrons (DAN) experiment for NASA's 2009 Mars Science Laboratory.

    PubMed

    Litvak, M L; Mitrofanov, I G; Barmakov, Yu N; Behar, A; Bitulev, A; Bobrovnitsky, Yu; Bogolubov, E P; Boynton, W V; Bragin, S I; Churin, S; Grebennikov, A S; Konovalov, A; Kozyrev, A S; Kurdumov, I G; Krylov, A; Kuznetsov, Yu P; Malakhov, A V; Mokrousov, M I; Ryzhkov, V I; Sanin, A B; Shvetsov, V N; Smirnov, G A; Sholeninov, S; Timoshenko, G N; Tomilina, T M; Tuvakin, D V; Tretyakov, V I; Troshin, V S; Uvarov, V N; Varenikov, A; Vostrukhin, A

    2008-06-01

    We present a summary of the physical principles and design of the Dynamic Albedo of Neutrons (DAN) instrument onboard NASA's 2009 Mars Science Laboratory (MSL) mission. The DAN instrument will use the method of neutron-neutron activation analysis in a space application to study the abundance and depth distribution of water in the martian subsurface along the path of the MSL rover.

  7. Probing the microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides.

    PubMed

    Kimura, Takumi; Kawai, Kiyohiko; Majima, Tetsuro

    2006-04-14

    The environment-sensitive fluorophore dan (6-dimethylamino-2-acyl-naphthalene)- modified dC or dG bases were introduced into the Z-DNA forming sequence. It was demonstrated that both grooves of Z-DNA are more hydrated than those of B-DNA. Dan will be useful for probing the microenvironments in the grooves among the DNA polymorphs.

  8. Dan Olweus: Award for Distinguished Contributions to Research in Public Policy

    ERIC Educational Resources Information Center

    American Psychologist, 2012

    2012-01-01

    Presents a short biography of the winner of the American Psychological Association's Award for Distinguished Contributions to Research in Public Policy. The 2012 winner is Dan Olweus for his rigorous scientific research on bullying among children and youth and his early and tireless attention to its public policy implications. Dan Olweus's…

  9. The Dynamic Albedo of Neutrons (DAN) Experiment for NASA's 2009 Mars Science Laboratory

    NASA Astrophysics Data System (ADS)

    Litvak, M. L.; Mitrofanov, I. G.; Barmakov, Yu. N.; Behar, A.; Bitulev, A.; Bobrovnitsky, Yu.; Bogolubov, E. P.; Boynton, W. V.; Bragin, S. I.; Churin, S.; Grebennikov, A. S.; Konovalov, A.; Kozyrev, A. S.; Kurdumov, I. G.; Krylov, A.; Kuznetsov, Yu. P.; Malakhov, A. V.; Mokrousov, M. I.; Ryzhkov, V. I.; Sanin, A. B.; Shvetsov, V. N.; Smirnov, G. A.; Sholeninov, S.; Timoshenko, G. N.; Tomilina, T. M.; Tuvakin, D. V.; Tretyakov, V. I.; Troshin, V. S.; Uvarov, V. N.; Varenikov, A.; Vostrukhin, A.

    2008-06-01

    We present a summary of the physical principles and design of the Dynamic Albedo of Neutrons (DAN) instrument onboard NASA's 2009 Mars Science Laboratory (MSL) mission. The DAN instrument will use the method of neutron-neutron activation analysis in a space application to study the abundance and depth distribution of water in the martian subsurface along the path of the MSL rover.

  10. MALDI-MS analysis and imaging of small molecule metabolites with 1,5-diaminonaphthalene (DAN)

    SciTech Connect

    Korte, Andrew R; Lee, Young Jin

    2014-07-08

    1,5-diaminonaphthalene (DAN) has previously been reported as an effective matrix for matrix-assisted laser desorption ionization-mass spectrometry of phospholipids. In the current work, we investigate the use of DAN as a matrix for small metabolite analysis in negative ion mode. DAN was found to provide superior ionization to the compared matrices for MW < ~400 Da; however, 9-aminoacridine (9-AA) was found to be superior for a uridine diphosphate standard (MW 566 Da). DAN was also found to provide a more representative profile of a natural phospholipid mixture than 9-AA. Finally, DAN and 9-AA were applied for imaging of metabolites directly from corn leaf sections. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

  11. Adaptation of the Army Standard KN 01020 (aanpassing van de krijgsmachtnorm kn 01020)

    DTIC Science & Technology

    2005-01-01

    ect "Testmethoden De referenties naar andere nationale en milieuvriendelijke verfsystemen’. intemnationale normen zijn gecontroleerd e geactualiseerd...namen. - De referenties naar andere nationale en intemnationale normen zijn gecontroleerd en geactualiseerd. ONGERUBRICEERD ONGERUBRICEERD I TNO

  12. Blocage de Coulomb dans une boite quantique laterale contenant un faible nombre d'electrons

    NASA Astrophysics Data System (ADS)

    Gould, Charles

    Dans ce travail on utilise une nouvelle geometrie pour augmenter le controle sur le nombre d'electrons contenus dans une boite quantique laterale, et ainsi atteindre un regime de petit nombre d'electrons. Ces echantillons permettent une etude du blocage de Coulomb quand les electrons sont injectes a partir d'un gaz electronique a deux dimensions (2DEG). Les mesures a faible champ magnetique demontrent la grande flexibilite des echantillons et montrent que l'on peut faire varier le nombre d'electrons dans une boite quantique a partir de plus de 40 electrons jusqu'a un seul electron, ce qui est assez courant dans les boites quantiques verticales, mais ce qui n'avait jamais ete reussi dans une boite quantique laterale. Nos resultats montrent egalement que dans les boites quantiques laterales il est possible de determiner le spin du niveau qui participe au transport a l'aide du phenomene de blocage de spin. De plus, dans certaines circonstances il est meme possible de determiner le spin total de la boite quantique, ce qui peut avoir des applications pratiques dans des domaines tels l'informatique quantique. Les mesures dans le regime de renversement de spin a un champ magnetique plus eleve montrent l'importance des correlations electrons---electrons dans ces boites quantiques, qui menent a des depolarisations et a des structures de spins qui ont un effet sur le transport. En particulier, ces correlations menent a l'existence de niveaux excites de basse energie qui causent une dependance anormale de l'amplitude des pics de blocage de Coulomb en fonction de la temperature. Nos experiences demontrent egalement la possibilite d'utiliser ces boites quantiques comme sondes pour etudier les proprietes du bord d'un 2DEG. Une voie de recherche a etre exploree.

  13. NASA Administrator Dan Goldin greets 100-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Among the VIPs attending the launch of STS-99 is Captain Ralph Charles (left), standing next to NASA Administrator Dan Goldin. Charles hopes to have his wish fulfilled of watching a Shuttle launch in person. The 100-year-old aviator has experienced nearly a century of flight history, from the Wright Brothers to the Space Program. He took flying lessons from one of the first fliers trained by Orville Wright, first repaired then built airplanes, went barnstorming, operated a charter service in the Caribbean, and worked as a test pilot for the Curtiss Wright Airplane Co. Charles is the oldest licensed pilot in the United States, and is still flying.

  14. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) watches as 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA, shakes hands with astronaut Dog Wheelock. Behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  15. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) shares a laugh with VIP 10- year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

  16. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) shares a light moment during his meeting with 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  17. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Ten-year-old Jonathan Pierce (second from right), who is garbed in a protective cooling suit, without the helmet, which was designed by NASA, poses with (left to right) NASA Administrator Dan Goldin, Mrs. Goldin, and astronaut Doug Wheelock. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

  18. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) listens intently to 10-year- old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

  19. Spin-dependent parameters P/sub n/000, D/sub n/0n0, K/sub n/00n, D/sub s/0s0, D/sub s/0k0, M/sub s/0sn, and M/sub s/0kn in pp elastic scattering at 579 MeV

    SciTech Connect

    Aprile, E.; Hausammann, R.; Heer, E.; Hess, R.; Lechanoine-Leluc, C.; Leo, W.R.; Morenzoni, S.; Onel, Y.; Rapin, D.; Mango, S.

    1983-06-01

    The polarization parameter P/sub n/000, the two-spin parameters D/sub n/0n0, K/sub n/00n, D/sub s/0s0, and D/sub s/0k0, and the three-spin parameters M/sub s/0sn and M/sub s/0kn have been measured for pp elastic scattering at 579 MeV between 34/sup 0/ and 118/sup 0/ center-of-mass scattering angle. The experiment was performed at SIN using a polarized proton beam, a polarized butanol target, and a polarimeter for the measurement of the polarization of the scattered proton. These data form the basis for a complete experimental determination of the scattering amplitudes.

  20. Production du baryon Sigma+ dans les collisions e+e- au LEP

    NASA Astrophysics Data System (ADS)

    Joly, Andre

    Les mécanismes de production des baryons dans les interactions e+e- font l'objet de nombreuses études. De plus, les modes de production des baryons étranges semblent faire appel A des processus spécifiques, qui sont encore mal compris. Notre étude de la production des baryons Σ+ dans les interactions e+e- nous permet de formuler certaines remarques sur l'état des connaîssances acquises sur le sujet. Une methode de reconstruction originale et des critères de sélection spécifiques ont été développés afin d'identifier des baryons Σ+ de haute Energie ( ES+ > 5 GeV), partir de leur canal de désintégration en un proton et un π0 (S+-->p+p0 ). Trois mesures principales sont réalisées à partir de notre échantillon de baryons reconstruits. Le nombre mesuré de baryons Σ+ produits par événement e +e- à 91 GeV est de: =0.102+/-0.006(stat.) +/-0.008(syst.) +/-0.003(extrap.) où les erreurs sont dues à la statistique, aux systématiques et à la procédure d'extrapolation. Ce résultat est en accord avec ceux obtenus précédemment, mais avec des erreurs réduites. La section efficace différentielle en fonction de l'energie est mesurée et comparée aux prédictions des principaux générateurs Monte-Carlo (JETSET7.4(MOPS), JETSET7.4 et HERWIG5.9). A haute énergie, HERWIG ne semble pas reproduire les mesures, aussi bien que les deux versions de JETSET. Enfin, la position du maximum de la section efficace différentielle de production des baryons Σ+ en fonction de l'impulsion est mesurée. On trouve: overlinexoverlineS+=2.32+/- 0.47 Une étude spécifique du générateur JETSET7.4(MOPS) est réalisee, afin de mieux comprendre les mécanismes de production de l'étrangeté et du spin dans la production des baryons. Aucun générateur ne semble capable de décrire de manière simultanée la production du spin et de l'étrangeté.

  1. Etude du Photochromisme et de la Photorefractivite dans le Poly

    NASA Astrophysics Data System (ADS)

    Ghailane, Fatima

    1995-11-01

    Nous avons etudie la possibilite d'utiliser un materiau organique, le poly(vinylcarbazole) comme milieu de stockage optique de masse en temps reel. Ce materiau dope aux photochromes presente un potentiel non negligeable pour l'holographie de volume en temps reel. Plusiers cycles, Ecriture-Lecture-Effacement, ont ete enregistres dans cette matrice polymerique avec une resolution assez elevee. Une etude a ete menee afin d'obtenir la valeur des parametres comme l'epaisseur du film et l'intensite d'ecriture pour un angle d'enregistrement theta_{ acute ecriture} donne qui permettent d'obtenir les meilleures efficacites diffractionelles tout en preservant ce milieu de tout effet de fatigue ou de degradation. Ce polymere devient photorefractif une fois melange avec un bon accepteur de charge, le trinitrofluorenone et un bon chromophore non-lineaire, le disperse orange 25. Nous avons etudie experimentalement la conductivite en obscurite et la photoconductivite de ce materiau. Des simulations numeriques ont ete realisees en se basant sur le modele de Poole-Frenkel. Nous avons aussi etudie l'implantation de faisceaux d'ions d'oxygene d'energie 200 keV pour inscrire dans le PVCz un guide d'onde plan a profil d'indice. Une etude ESCA complete cette partie afin de savoir les modifications induites par implementation ionique a l'interieur du film polymerique.

  2. Formation des etoiles massives dans les galaxies spirales

    NASA Astrophysics Data System (ADS)

    Lelievre, Mario

    Le but de cette thèse est de décrire la formation des étoiles massives dans les galaxies spirales appartenant à divers types morphologiques. L'imagerie Hα profonde combinée à une robuste méthode d'identification des régions HII ont permis de détecter et de mesurer les propriétés (position, taille, luminosité, taux de formation d'étoiles) de plusieurs régions HII situées dans le disque interne (R < R25) de dix galaxies mais aussi à leur périphérie (R ≥ R 25). De façon générale, la répartition des régions HII ne montre aucune évidence de structure morphologique à R < R25 (bras spiraux, anneau, barre) à moins de limiter l'analyse aux régions HII les plus grosses ou les plus lumineuses. La répartition des régions HII, de même que leur taille et leur luminosité, sont toutefois sujettes à de forts effets de sélection qui dépendent de la distance des galaxies et qu'il faut corriger en ramenant l'échantillon à une résolution spatiale commune. Les fonctions de luminosité montrent que les régions HII les plus brillantes ont tendance à se former dans la portion interne du disque. De plus, l'analyse des pentes révèle une forte corrélation linéaire par rapport au type morphologique. Aucun pic n'est observé dans les fonctions de luminosité à log L-37 qui révèlerait la transition entre les régions HII bornées par l'ionisation et par la densité. Une relation cubique est obtenue entre la taille et la luminosité des régions HII, cette relation variant toutefois de façon significative entre le disque interne et la périphérie d'une même galaxie. La densité et la dynamique du gaz et des étoiles pourraient influencer de façon significative la stabilité des nuages moléculaires face à l'effondrement gravitationnel. D'une part, l'étendue du disque de régions HII pour cinq galaxies de l'échantillon coïncide avec celle de l'hydrogène atomique. D'autre part, en analysant la stabilité des disques galactiques, on conclue

  3. Analyzing of the Die Away Curve of the Msl Dynamic Albedo of Neutrons (dan) Instrument

    NASA Astrophysics Data System (ADS)

    Varenikov, A.; Jun, I.; Litvak, M. L.

    2012-12-01

    The Dynamic Albedo of Neutrons (DAN) is flown on board Mars Science Laboratory (MSL) to provide measurements of the dynamic albedo of thermal and epithermal neutrons induced by a pulse 14 MeV neutron generator. The DAN instrument consists of pulse neutron generator (DAN/PNG) electrically and logically combined with neutron detection system (DAN/DE). The major science objective of DAN instrument is to detect and provide quantitative estimates of the hydrogen content in the sub-surface layer of Mars. The amplitude and shape of the die-away time profile strongly depends on the content, depth and geometry distribution of water ice/bound layer. Die-away curves of thermal neutrons are simulated using a Monte Carlo transport code (MCNPX) for a homogeneous model of regolith with different contents of water. Tw different cases were considered in the initial simulations: single layered model and double layered model. In the first case, the sub-surface is modelled as a homogeneous single layer with different water contents. The preliminary results show that DAN could measure the water content as low as 0.1-0.2 weight %. The second case includes the sub-surface described by two layers. It is used to evaluate the DAN sensitivity to detect water depth (where the bottom layer is richer in water content than the upper layer).

  4. Interacting faults

    NASA Astrophysics Data System (ADS)

    Peacock, D. C. P.; Nixon, C. W.; Rotevatn, A.; Sanderson, D. J.; Zuluaga, L. F.

    2017-04-01

    The way that faults interact with each other controls fault geometries, displacements and strains. Faults rarely occur individually but as sets or networks, with the arrangement of these faults producing a variety of different fault interactions. Fault interactions are characterised in terms of the following: 1) Geometry - the spatial arrangement of the faults. Interacting faults may or may not be geometrically linked (i.e. physically connected), when fault planes share an intersection line. 2) Kinematics - the displacement distributions of the interacting faults and whether the displacement directions are parallel, perpendicular or oblique to the intersection line. Interacting faults may or may not be kinematically linked, where the displacements, stresses and strains of one fault influences those of the other. 3) Displacement and strain in the interaction zone - whether the faults have the same or opposite displacement directions, and if extension or contraction dominates in the acute bisector between the faults. 4) Chronology - the relative ages of the faults. This characterisation scheme is used to suggest a classification for interacting faults. Different types of interaction are illustrated using metre-scale faults from the Mesozoic rocks of Somerset and examples from the literature.

  5. Identification and expression analysis of BMP signaling inhibitors genes of the DAN family in amphioxus.

    PubMed

    Le Petillon, Yann; Oulion, Silvan; Escande, Marie-Line; Escriva, Hector; Bertrand, Stephanie

    2013-12-01

    Bone morphogenetic proteins (BMPs) are members of the Transforming Growth Factor-β (TGF-β) family implicated in many developmental processes in metazoans such as embryo axes specification. Their wide variety of actions is in part controlled by inhibitors that impede the interaction of BMPs with their specific receptors. Here, we focused our attention on the Differential screening-selected gene Aberrative in Neuroblastoma (DAN) family of inhibitors. Although they are well-characterized in vertebrates, few data are available for this family in other metazoan species. In order to understand the evolution of potential developmental roles of these inhibitors in chordates, we identified the members of this family in the cephalochordate amphioxus, and characterized their expression patterns during embryonic development. Our data suggest that the function of Cerberus/Dand5 subfamily genes is conserved among chordates, whereas Gremlin1/2 and NBL1 subfamily genes seem to have acquired divergent expression patterns in each chordate lineage. On the other hand, the expression of Gremlin in the amphioxus neural plate border during early neurulation strengthens the hypothesis of a conserved neural plate border gene network in chordates.

  6. Sur la nature des absorbeurs dans l'interpretation transactionnelle de la mecanique quantique

    NASA Astrophysics Data System (ADS)

    Boisvert, Jean-Sebastien

    L'interpretation transactionnelle de la mecanique quantique est l'une des plus recentes propositions de description des phenomenes du microcosme. En accord avec les predictions de la mecanique quantique standard, l'interpretation transactionnelle propose une alternative a celle de Copenhague. Son principal avantage est qu'elle permet de visualiser les mecanismes sous-jacents a l'echange d'energie, de quantite de mouvement ou d'autres quantites quantiques entre un emetteur et un absorbeur. Ces echanges sont le resultat, a l'instar de la theorie de l'absorbeur de Wheeler et Feynman, de l'utilisation autant d'ondes avancees que retardees. Bien que l'interpretation transactionnelle n'ait pas attire la plus grande attention scientifique, plusieurs critiques lui ont ete adressees. Dans les annees 1990, differentes experiences a mesure sans interaction ont ete concues. Depuis, il a ete avance que la version originale de l'interpretation transactionnelle pouvait difficilement rendre compte de ce type d'experience et meme qu'elle n'est pas compatible avec le concept d'univers quadridimensionnel. La recherche de ce memoire par article consiste a montrer que lorsque l'on utilise systematiquement l'interpretation transactionnelle en considerant la configuration totale des absorbeurs (incluant l'absorbeur universel), il n'est pas necessaire de faire appel a une hierarchie de transactions comme certains l'ont propose.

  7. Data processing of the active neutron experiment DAN for a Martian regolith investigation

    NASA Astrophysics Data System (ADS)

    Sanin, A. B.; Mitrofanov, I. G.; Litvak, M. L.; Lisov, D. I.; Starr, R.; Boynton, W.; Behar, A.; DeFlores, L.; Fedosov, F.; Golovin, D.; Hardgrove, C.; Harshman, K.; Jun, I.; Kozyrev, A. S.; Kuzmin, R. O.; Malakhov, A.; Milliken, R.; Mischna, M.; Moersch, J.; Mokrousov, M. I.; Nikiforov, S.; Shvetsov, V. N.; Tate, C.; Tret'yakov, V. I.; Vostrukhin, A.

    2015-07-01

    Searching for water in the soil of Gale Crater is one of the primary tasks for the NASA Mars Science Laboratory rover named Curiosity. The primary task of the Dynamic Albedo of Neutrons (DAN) experiment on board the rover is to investigate and qualitatively characterize the presence of water along the rover's traverse across Gale Crater. The water depth distribution may be found from measurements of neutrons generated by the Pulsing Neutron Generator (PNG) included in the DAN instrument, scattered by the regolith and returned back to the detectors. This paper provides a description of the data processing of such measurements and data products of DAN investigation.

  8. Imagined Interactions

    ERIC Educational Resources Information Center

    Honeycutt, James M.

    2010-01-01

    Social scientists have been studying imagined interactions since the mid-1980s and have measured numerous physiological correlates (Honeycutt, 2010). In this commentary I assess the research reported in Crisp and Turner (May-June 2009) and highlight the underlying mechanisms of imagined interactions that have empirically been laid out across…

  9. Efficient quantum transport in disordered interacting many-body networks.

    PubMed

    Ortega, Adrian; Stegmann, Thomas; Benet, Luis

    2016-10-01

    The coherent transport of n fermions in disordered networks of l single-particle states connected by k-body interactions is studied. These networks are modeled by embedded Gaussian random matrix ensemble (EGE). The conductance bandwidth and the ensemble-averaged total current attain their maximal values if the system is highly filled n∼l-1 and k∼n/2. For the cases k=1 and k=n the bandwidth is minimal. We show that for all parameters the transport is enhanced significantly whenever centrosymmetric embedded Gaussian ensemble (csEGE) are considered. In this case the transmission shows numerous resonances of perfect transport. Analyzing the transmission by spectral decomposition, we find that centrosymmetry induces strong correlations and enhances the extrema of the distributions. This suppresses destructive interference effects in the system and thus causes backscattering-free transmission resonances that enhance the overall transport. The distribution of the total current for the csEGE has a very large dominating peak for n=l-1, close to the highest observed currents.

  10. Laser X-UV en schéma collisionnel OFI à 41,8 nm créé dans des tubes capillaires

    NASA Astrophysics Data System (ADS)

    Vieux, G.; Cros, B.; Maynard, G.; Mocek, T.; Bettaibi, I.; Farinet, M.; Dubau, J.

    2006-12-01

    Nous présentons les résultats expérimentaux et théoriques obtenus sur le laser X-UV à 41,8 nm créé en schéma collisisonnel à ionisation par champ optique dans des tubes capillaires. Une étude détaillée a été menée dans le but de comprendre les effets liés au guidage. Le plasma amplificateur est créé dans un tube capillaire de quelques cm de long. L'émission X-UV maximum est obtenue en fonctionnant en régime de guidage multimode dans un tube capillaire de 25 mm de long. Le signal X-UV mesuré est 3 fois plus élevé que celui observé dans une cellule de gaz et la divergence du faisceau est réduite d'un facteur3. Un code numérique, baptisé COFIXE, est en développement pour calculer le signal X-UV émis par le plasma amplificateur. Il inclut le calcul de la propagation du faisceau pompe, de l'état du plasma juste après l'interaction avec le faisceau pompe, le calcul de l'évolution des propriétés locales du plasma pendant les quelques ps suivantes ainsi que le calcul de l'amplification et du transport de l'émission X-UV. Un très bon accord a été obtenu entre les résultats expérimentaux et les résultats théoriques pour plusieurs caractéristiques telles la divergence du faisceau, la corrélation entre la transmission du faisceau pompe guidé et l'énergie du signal X-UV, ainsi que l'amélioration apportée par le guidage.

  11. Transition de phase quantique de type verrouillage-deverrouillage dans les canaux lineaires coherents des phases en rayures dans les doubles puits quantiques sous champ magnetique perpendiculaire

    NASA Astrophysics Data System (ADS)

    Faribault, Alexandre

    On peut creer un gaz electronique bidimensionnel en utilisant le potentiel de confinement d'une couche mince d'un semiconducteur dans un substrat fait d'une autre semiconducteur de gap plus eleve. L'ajout d'un champ magnetique perpendiculaire au plan de confinement modifie de facon drastique les proprietes du gaz electronique. Pour des densites et des valeurs du champ magnetique adequatement choisies, on obtient un etat fondamental en onde de densite de charge. Dans un systeme compose de deux de ces gaz bidimensionnels suffisamment rapproches l'un de l'autre, on prevoit theoriquement l'existence d'un etat fondamental compose d'une onde de densite de charge dans chacun des puits et d'une serie de regions lineaires ou l'on a une delocalisation coherente des electrons entre les deux puits. Dans cette these, on etudie le comportement a temperature nulle de cet etat fondamental en rayures coherentes. L'etude numerique des modes collectifs de ces phases laisse croire qu'un deverrouillage des canaux coherents est envisageable dans ce systeme. Afin d'etudier cette possibilite, nous construisons d'abord un modele effectif de canaux quasi-unidimensionnels couples qui permettent de reproduire correctement les excitations collectives a basse energie de la phase en rayures coherentes du double puits quantique. Dans un systeme de coordonnees adequatement choisi, ces excitations peuvent etre decrites par des ondes de pseudospin. Les parametres de ce modele effectif simple peuvent etre extraits des calculs des fonctions de reponse realises dans l'approximation Hartree-Fock dependante du temps (appelee aussi Generalized Random Phase Approximation). On constate l'efficacite de ce modele a decrire la dynamique basse energie du systeme pour une certaine plage de distances inter-puits. En retirant de ce modele les contributions a l'hamiltonien provenant des couplages de type Josephson entre les canaux, on obtient alors un systeme ou les canaux sont deverrouilles. Un traitement en

  12. Etude des interdiffusions en phase solide dans le contact Ni/AlAs

    NASA Astrophysics Data System (ADS)

    Députier, S.; Guivarc'h, A.; Caulet, J.; Poudoulec, A.; Guenais, B.; Minier, M.; Guérin, R.

    1995-04-01

    éposée dans des conditions d'ultra-vide et des couches épaisses d'AlAs épitaxiées sur des substrats de GaAs orientés (001) et (111) ont été étudiées après des traitements thermiques d'une heure, sous balayage de gaz neutres, entre 200 et 600 ^{circ}C. L'utilisation de techniques complémentaires d'analyse (RBS, diffraction X, MET) a permis de mettre en évidence, en fonction de la température de recuit, plusieurs étapes successives d'interaction. Ces étapes correspondent soit à des phases ternaires, mises en évidence lors de la détermination expérimentale du diagramme Ni-Al-As et notées A, B, D par analogie avec celles du diagramme Ni-Ga-As, soit à des mélanges de phases constituées de binaires et/ou de ternaires, toutes ces phases étant plus ou moins fortement texturées sur le substrat. En fait, la nature des phases en présence dépend de l'orientation du substrat, la cinétique de réaction apparaissant plus lente pour l'interaction Ni/AlAs(111) que pour celle Ni/AlAs(001), les étapes successives sont observées : tout d'abord un mélange constitué de la phase ternaire B + NiAl puis un autre mélange : phase ternaire A + NiAl + NiAs et en fin d'interaction les deux binaires : NiAl + NiAs. Sur AlAs(111), seules deux étapes sont mises en évidence, la première correspond à la phase ternaire D, la seconde, en fin d'interaction, est constituée du mélange : phase B + NiAl + NiAs. On remarque dans ce cas le recuit à 600 ^{circ}C n'est pas suffisant pour atteindre le mélange des binaires NiAl et NiAs qui, selon le diagramme ternaire, est le stade ultime de l'interaction Ni/AlAs. L'analyse comparée des interdiffusions Ni/AlAs et Ni/GaAs montre que NiAl est le composé “clé” autour duquel pivote l'interaction Ni/AlAs alors que ce rôle était joué par NiAs lors des interdiffusions Ni/GaAs. Thermiquement stable et fortement texturé sur AlAs, le binaire NiAl apparaît comme un candidat prometteur pour la réalisation d'hétérostructures NiAl/AlAs/GaAs.

  13. Interacting parasites

    USGS Publications Warehouse

    Lafferty, Kevin D.

    2010-01-01

    Parasitism is the most popular life-style on Earth, and many vertebrates host more than one kind of parasite at a time. A common assumption is that parasite species rarely interact, because they often exploit different tissues in a host, and this use of discrete resources limits competition (1). On page 243 of this issue, however, Telfer et al. (2) provide a convincing case of a highly interactive parasite community in voles, and show how infection with one parasite can affect susceptibility to others. If some human parasites are equally interactive, our current, disease-by-disease approach to modeling and treating infectious diseases is inadequate (3).

  14. NASA Administrator Dan Goldin watches the STS-99 launch

    NASA Technical Reports Server (NTRS)

    2000-01-01

    KENNEDY SPACE CENTER, FLA. -- NASA Administrator Dan Goldin (right) joins other spectators at the Banana Creek viewing site in cheering the successful launch of Space Shuttle Endeavour on mission STS-99. The perfect liftoff occurred at 12:43:40 p.m. EST. Known as the Shuttle Radar Topography Mission (SRTM), STS-99 will chart a new course to produce unrivaled 3-D images of the Earth's surface. The result of the SRTM could be close to 1 trillion measurements of the Earth's topography. The mission is expected to last 11days, with Endeavour landing at KSC Tuesday, Feb. 22, at 4:36 p.m. EST. This is the 97th Shuttle flight and 14th for Shuttle Endeavour.

  15. NASA Administrator Dan Goldin greets 100-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Astronaut Andy Thomas (left) greets 100-year-old Captain Ralph Charles, one of the VIPs attending the launch of STS-99. Charles also met NASA Administrator Dan Goldin. An aviator who has the distinction of being the oldest licensed pilot in the United States, Charles is still flying. He has experienced nearly a century of flight history, from the Wright Brothers to the Space Program. He took flying lessons from one of the first fliers trained by Orville Wright, first repaired then built airplanes, went barnstorming, operated a charter service in the Caribbean, and worked as a test pilot for the Curtiss Wright Airplane Co. Charles watches all the Shuttle launches from his home in Ohio and his greatest wish is to be able to watch one in person from KSC.

  16. Institutional Pathology and the Death of Dan Markingson.

    PubMed

    Elliott, Carl

    2017-01-01

    In the spring of 2015, 11 years after a mentally ill young man named Dan Markingson stabbed himself to death in an industry-sponsored drug study, officials at the University of Minnesota suspended recruitment of subjects into drug trials in its Department of Psychiatry. University officials agreed to act only after a scathing investigation by Minnesota Office of the Legislative Auditor found damning evidence of coerced recruitment, inadequate clinical care, superficial research oversight, a web of serious, disturbing conflicts of interest, and a pattern of misleading public statements by university officials aimed at deflecting scrutiny. In this article, I examine the larger institutional factors leading up to Markingson's suicide and prevented corrective action for so long.

  17. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (center) greets 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie.. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  18. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (center) presents a bag of special gifts to 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie.. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  19. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (center) talks to 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  20. Injectabilite des coulis de ciment dans des milieux fissures

    NASA Astrophysics Data System (ADS)

    Mnif, Thameur

    Le travail presente ici est un bilan du travaux de recherche effectues sur l'injectabilite des coulis de ciment dans lu milieux fissures. Un certain nombre de coulis a base de ciment Portland et microfin ont ete selectionnes afin de caracteriser leur capacite a penetrer des milieux fissures. Une partie des essais a ete menee en laboratoire. L'etude rheologique des differents melanges a permis de tester l'influence de l'ajout de superplastifiant et/ou de fumee de silice sur la distribution granulometrique des coulis et par consequent sur leur capacite a injecter des colonnes de sable simulant un milieu fissure donne. La classe granulometrique d'un coulis, sa stabilite et sa fluidite sont apparus comme les trois facteurs principaux pour la reussite d'une injection. Un facteur de finesse a ete defini au cours de cette etude: base sur la classe granulometrique du ciment et sa stabilite, il peut entrer dans la formulation theorique du debit d'injection avant application sur chantier. La deuxieme et derniere partie de l'etude presente les resultats de deux projets de recherche sur l'injection realises sur chantier. L'injection de dalles de beton fissurees a permis le suivi de l'evolution des pressions avec la distance au point d'injection. L'injection de murs de maconnerie a caractere historique a montre l'importance de la definition de criteres de performance des coulis a utiliser pour traiter un milieu donne et pour un objectif donne. Plusieurs melanges peuvent ainsi etre predefinis et mis a disposition sur le chantier. La complementarite des ciments traditionnels et des ciments microfins devient alors un atout important. Le choix d'utilisation de ces melanges est fonction du terrain rencontre. En conclusion, cette recherche etablit une methodologie pour la selection des coulis a base de ciment et des pressions d'injection en fonction de l'ouverture des fissures ou joints de construction.

  1. Structure of Protein Related to DAN and Cerberus (PRDC): Insights into the Mechanism of BMP Antagonism

    PubMed Central

    Nolan, Kristof; Kattamuri, Chandramohan; Luedeke, David M.; Deng, Andy; Jagpal, Amrita; Zhang, Fuming; Linhardt, Robert; Kenny, Alan P.; Zorn, Aaron M.; Thompson, Thomas B.

    2013-01-01

    Summary The Bone Morphogenetic Proteins (BMP) are secreted ligands largely known for their functional roles in embryogenesis and tissue development. A number of structurally diverse extracellular antagonists inhibit BMP ligands to regulate signaling. The DAN family of antagonists represents the largest group of BMP inhibitors, however, little is known for how they mechanistically inhibit BMP ligands. Here, we present the structure of the DAN family member Protein Related to Dan and Cerberus (PRDC) solved by X-ray crystallography. The structure reveals an unexpected growth factor-like appearance with a novel dimerization mechanism that is formed through extensive β-strand contacts. Using site-directed mutagenesis coupled with in vitro and in vivo activity assays, we identified a BMP binding epitope on PRDC. We also determined that PRDC binds heparin with high affinity and that heparin binding to PRDC interferes with BMP antagonism. These results offer insight for how DAN family antagonists functionally inhibit BMP ligands. PMID:23850456

  2. La Transmission de l'information dans une ecole (Information Transmission in a School Situation)

    ERIC Educational Resources Information Center

    Versel, Simone

    1973-01-01

    Selected portions of a longer paper entitled "Incidence relationnelle et institutionelle de la transmission de l'information dans une ecole," presented at the Institut Superieur de Pedagogie, 1973. (HW)

  3. Dynamic Albedo of Neutrons (DAN): Active Nuclear Experiment Onboard NASA Mars Science Laboratory

    NASA Astrophysics Data System (ADS)

    Mitrofanov, I. G.; Litvak, M. L.; Kozyrev, A. S.; Mokrousov, M. I.; Sanin, A. B.; Tretyakov, V. I.

    2005-03-01

    In our presentation we describe instrument DAN based on neutron activation technique and selected for NASA/MSL mission. The main task of this experiment is local measuruments of water distribution in martian subsurface around MSL rover.

  4. Cue Integration in Dynamic Decision Marking (Integration des indices dans la Prise de Decision Dynamique)

    DTIC Science & Technology

    2010-07-01

    environnements complexes et dynamiques. La nature complexe et dynamique de differents types d’operations (p. ex., les operations basees sur les...destinees a preparer les commandants et le personnel des etats- majors des Forces canadiennes (FC) a prendre des decisions dans des environnements ...Ia prise de decisions dans les environnements complexes et dynamiques est habituellement designee sous le nom de prise de decisions dynamique (POD

  5. Transitions de phase dans le oxyde de yttrium vanadium

    NASA Astrophysics Data System (ADS)

    Roberge, Benoit

    Dans le mémoire qui suit, les ordres structural, magnétiques et orbital dans le YVO3 sont étudiés avec l'aide de la diffraction des rayons X,de la spectroscopie Raman et de la technique de la cavité résonnante hyperfréquence. L'objectif premier consiste à observer l'évolution de ces ordres en fonction de la température. Le mémoire met ensuite en évidence le couplage entre les différents ordres cohabitants dans le YVO3 . Les mesures effectuées par la diffraction des rayons X permettent de mesurer le caractère polycrystallin des échantillons du YVO 3. Une comparaison de nos mesures avec des mesures de diffraction des rayons X faites sur la poudre de YVO3 indique la faible présence de maclage. Les mesures effectuées avec la technique de résonnance hyperfréquence permettent de suivre l'évolution de la constante diélectrique en fonction de la température. Les changements impliquant l'ordre orbital se manifestent de manière évidente dans la constante diélectrique à 200 K et à 77 K. La transition diélectrique détectée à 77 K est une transition de premier ordre. Un couplage entre les propriétés diélectriques et magnétiques est observable à la température de Néel à 114 K. L'effet d'un champ magnétique fixe sur la température de transition de l'ordre orbital survenant à 77 K est également remarquable. Cela indique un couplage magnétodiélectrique démontrant ainsi le caractère multiferroïque du YVO 3. Finalement, l'observation d'un mécanisme de relaxation pouvant être modélisé par le modèle d'Havriliak-Negami est observé en dessous de 77 K. En utilisant le modèle d'Arrhénius et le modèle d'Havriliak-Negami, on peut caractériser le mécanisme avec son énergie d'activation et son temps de relaxation. Les mesures effectuées en spectroscopie Raman permettent de suivre l'évolution de la structure du YVO3 en fonction de la température. Les deux changements structuraux survenant à 200 K et 77 K sont observés. Le

  6. Strong Interaction

    SciTech Connect

    Karsch, F.; Vogelsang, V.

    2009-09-29

    We will give here an overview of our theory of the strong interactions, Quantum Chromo Dynamics (QCD) and its properties. We will also briefly review the history of the study of the strong interactions, and the discoveries that ultimately led to the formulation of QCD. The strong force is one of the four known fundamental forces in nature, the others being the electromagnetic, the weak and the gravitational force. The strong force, usually referred to by scientists as the 'strong interaction', is relevant at the subatomic level, where it is responsible for the binding of protons and neutrons to atomic nuclei. To do this, it must overcome the electric repulsion between the protons in an atomic nucleus and be the most powerful force over distances of a few fm (1fm=1 femtometer=1 fermi=10{sup -15}m), the typical size of a nucleus. This property gave the strong force its name.

  7. Les fluctuations supraconductrices dans le compose praseodyme-cerium-oxyde de cuivre

    NASA Astrophysics Data System (ADS)

    Renaud, Jacques

    Ce travail etudie les fluctuations supraconductrices dans le compose supraconducteur a haute temperature critique dope aux electrons Pr2-xCe xCuO4+delta. La technique utilisee pour sonder ces fluctuations est le transport electrique DC dans le plan ab. Il s'agit, a notre connaissance, de la premiere etude de ce type dans la classe generale des supraconducteurs a haute temperature critique dopes aux electrons et, plus particulierement, dans Pr2-xCe xCuO4+delta. De plus, l'etude est effectuee pour trois regimes de dopage, soit sous-dope x = 0.135, dopage optimal x = 0.15 et surdope x = 0.17. Les echantillons etudies sont des couches minces d'epaisseur plus grande que 100 nm crues par ablation laser. Les mesures electriques DC effectuees dans ce travail sont la resistance en reponse lineaire et les courbes IV en reponse non lineaire en fonction de la temperature. La mise en oeuvre experimentale de ces mesures a necessite une grande attention au filtrage et aux effets de chauffage a haut courant. Nous montrons que, sans cette attention, les donnees experimentales sont toujours erronees dans le regime pertinent pour nos echantillons. Les resultats pour le dopage optimal x = 0.15 sont expliques de facon tres convaincante dans le cadre de fluctuations purement 2D. D'abord, le regime des fluctuations gaussiennes est tres bien decrit par le modele d'Aslamazov-Larkin en deux dimensions. Ensuite, le regime de fluctuations critiques, se trouvant a plus basse temperature que le regime gaussien, est tres bien decrit par la physique 2D de Kosterlitz-Thouless. Dans cette analyse, les deux regimes ont des temperatures critiques coherentes entre elles, ce qui semble confirmer ce scenario 2D. Une analyse des donnees dans le cadre de fluctuations 3D est exploree mais donne des conclusions incoherentes. Les resultats pour les autres dopages sont qualitativement equivalents avec le dopage optimal et permettent donc une explication purement 2D. Par contre, contrairement au dopage optimal

  8. Effect of model selection on combustor performance and stability using ROCCID. [Rocket Combustor Interactive Design

    NASA Technical Reports Server (NTRS)

    Giuliani, James E.; Klem, Mark D.

    1992-01-01

    The ROCket Combustor Interactive Design (ROCCID) methodology is an interactive computer program that combines previously developed combustion analysis models to calculate the combustion performance and stability of liquid rocket engines. Test data from a 213 kN (48,000 lbf) Liquid Oxygen (LOX)/RP-1 combustor with a O-F-O (oxidizer-fuel-oxidizer) triplet injector were used to characterize the predictive capabilities of the ROCCID analysis models for this injector/propellant configuration. Thirteen combustion performance and stability models have been incorporated into ROCCID, and ten of them, which have options for triplet injectors, were examined in this study. Calculations using different combinations of analysis models, with little or no anchoring, were carried out on a test matrix of operating conditions matching those of the test program. Results of the computer analyses were compared to test data, and the ability of the model combinations to correctly predict combustion stability or instability was determined. For the best model combination(s), sensitivity of the calculations to fuel drop size and mixing efficiency was examined. Error in the stability calculations due to uncertainty in the pressure interaction index (N) was examined. The recommended model combinations for this O-F-O triplet LOX/RP-1 configuration are proposed.

  9. CALCIUM-DEPENDENT INTERACTIONS OF THE HUMAN NOREPINEPHRINE TRANSPORTER WITH SYNTAXIN 1A

    PubMed Central

    Sung, Uhna; Blakely, Randy D.

    2007-01-01

    The norepinephrine (NE) transporter (NET) terminates noradrenergic signaling by clearing released NE at synapses. The activity of NET can be rapidly regulated by depolarization and receptor activation via Ca2+ and kinase/phosphatase linked pathways. The SNARE protein syntaxin 1A (SYN1A) interacts with NET and influences transporter surface trafficking and catalytic activity. In this study, we establish a link between changes in intracellular Ca2+ and SYN1A/NET interactions. SYN1A influenced NE transport only in the presence of Ca2+ in brain cortical synaptosomes. Although NET/SYN1A associations were sensitive to manipulations of Ca2+ in CHO cells, in vitro binding experiments using purified NET and SYN1A fusion proteins demonstrated a lack of direct Ca2+ sensitivity. Disruption of NET/SYN1A interaction abolished inhibition of NE transport by phorbol ester (PMA) to activate protein kinase C (PKC), but had no effect on transport inhibition by the Ca2+ calmodulin kinase (CaMK) inhibitor KN93. Furthermore, PMA enhanced Ca2+ dependent modulation of NE transport in synaptosomes. Our data reveal roles for SYN1A in the Ca2+-dependent regulation of NET, likely reliant on regulation by PKC signaling, but independent of CaMK. PMID:17188889

  10. Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

    PubMed Central

    Bouchet, Benjamin P; Gough, Rosemarie E; Ammon, York-Christoph; van de Willige, Dieudonnée; Post, Harm; Jacquemet, Guillaume; Altelaar, AF Maarten; Heck, Albert JR; Goult, Benjamin T; Akhmanova, Anna

    2016-01-01

    The cross-talk between dynamic microtubules and integrin-based adhesions to the extracellular matrix plays a crucial role in cell polarity and migration. Microtubules regulate the turnover of adhesion sites, and, in turn, focal adhesions promote the cortical microtubule capture and stabilization in their vicinity, but the underlying mechanism is unknown. Here, we show that cortical microtubule stabilization sites containing CLASPs, KIF21A, LL5β and liprins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the major adhesion component, talin. Structural studies showed that the conserved KN domain in KANK1 binds to the talin rod domain R7. Perturbation of this interaction, including a single point mutation in talin, which disrupts KANK1 binding but not the talin function in adhesion, abrogates the association of microtubule-stabilizing complexes with focal adhesions. We propose that the talin-KANK1 interaction links the two macromolecular assemblies that control cortical attachment of actin fibers and microtubules. DOI: http://dx.doi.org/10.7554/eLife.18124.001 PMID:27410476

  11. Weak Interactions

    DOE R&D Accomplishments Database

    Lee, T. D.

    1957-06-01

    Experimental results on the non-conservation of parity and charge conservation in weak interactions are reviewed. The two-component theory of the neutrino is discussed. Lepton reactions are examined under the assumption of the law of conservation of leptons and that the neutrino is described by a two- component theory. From the results of this examination, the universal Fermi interactions are analyzed. Although reactions involving the neutrino can be described, the same is not true of reactions which do not involve the lepton, as the discussion of the decay of K mesons and hyperons shows. The question of the invariance of time reversal is next examined. (J.S.R.)

  12. Sur le chaos Lagrangien dans une cuve elliptique

    NASA Astrophysics Data System (ADS)

    Saatdjian, E.; Chassaing, M. I.; Midoux, N.; André, J. C.

    1995-02-01

    A viscous fluid is introduced into the annular space between two concentric, confocal ellipses. The inner and outer walls can be displaced along their circumference. A small quantity of fluorescent dye is introduced into the fluid and deformation and mixing are studied for the case of periodic boundary movement. An analytical solution in elliptical coordinates has been previously derived for creeping flow conditions. Poincaré sections for a given set of parameters indicate that counter-rotation leads to a more chaotic behaviour than co-rotation, this result is confirmed experimentally. This geometry can also be used as a heat exchanger. By a suitable choice of the parameters, the heat transfer for steady boundary motion can be increased by more than 50% with respect to the concentric cylinder system. If the inner and outer walls are displaced time-periodically, the heat transfer rate obtained can be more than double the rate obtained between concentric cylinders. Un fluide visqueux est introduit dans une cuve de géométrie elliptique, les parois interne et externe de cette cuve tournent suivant le périmètre de l'ellipse. Une petite quantité de traceur fluorescent est introduite dans le fluide et la déformation de l'élément marqué, lorsque le mouvement des deux parois est périodique, est étudiée. Pour cet écoulement où le nombre de Reynolds est très inférieur à 1 (régime de Stokes) et à partir d'une solution analytique récemmnent obtenue pour le cas stationnaire, des sections de Poincaré ont été tracées pour le cas d'une contra-rotation et d'une co-rotation. Les résultats expérimentaux montrent que, pour un protocole de mélange discontinu approprié, cette géométrie mène vers un mélange chaotique après un petit nombre de périodes. Par ailleurs, il est préférable de faire tourner les ellipses en contra-rotation. Ce résultat, en contradiction avec ceux déjà obtenus dans l'espace annulaire entre cylindres excentrés tournants, est

  13. Réactions chimiques et courant de transport dans la phase Bi2223

    NASA Astrophysics Data System (ADS)

    Duperray, G.; Legat, D.; Savary, H.

    1994-11-01

    To get high transport capacities in magnetic field with Ag sheathed conductors, the Bi2223 phase must be free of residual phases, well-crystallized, the lamellas being parallel with the current lines and very dense. In a research context on multifilamentary conductor, a preliminary study has been done on bulk material (1 × 4 × 40 mm^3 bars) to optimize the frabrication parameters of the multifilamentary tapes. A lot of samples, corresponding to the different operating conditions have been electrically characterized and analyzed by EDS so as to get some correlations between microstructure and superconducting performances : determination, concentration and repartition of residual phases, crystallinity, orientation and compacity of the Bi2223 phase. We also examined the interactions between the " refractory phases ", (Ca, Sr)2CuO3 ; (Ca, Sr) CuO2, ; CuO and the liquid phase, Bi2212 enriched with Bi and Sr + (Ca, Sr)2PbO4 which promote the recombination into pure and well recristallized Bi2223 phase. Maximum transport current capacities at 77 K-O T were 11 A/mm^2 for a commercial powder and 17 A/mm^2 (47 A) for a laboratory type powder, the values being around 50 A/mm^2 for the corresponding multifilamentary conductors. Pour qu'un fil supraconducteur gainé d'argent présente une capacité de transport de courant élevée ainsi qu'une bonne tenue sous champ, il faut que la phase Bi2223 soit exempte de phases résiduelles, soit bien cristallisée en feuillets orientés dans le sens de passage du courant et soit compacte. Dans le contexte d'une recherche sur les conducteurs multifilamentaires, nous avons mené une étude préliminaire sur matériau massif (barrettes de 1 × 4 × 40 mm^3) afin de déterminer les conditions physicochimiques optimales de fabrication de brins multifilamentaires. Un grand nombre d'échantillons, correspondant à différentes conditions opératoires et caractérisés électriquement, ont été analysés par EDS de façon à corréler les

  14. Interactive Astronomy.

    ERIC Educational Resources Information Center

    Martin, Jean K.

    1997-01-01

    Presents guiding principles for developing interactive lessons for the World Wide Web. Describes "Amazing Space: Education Online from the Hubble Space Telescope", a program where students study spectacular Hubble Space Telescope images of stars and star-forming regions to learn about the life cycle of stars and the creation of atoms. (JRH)

  15. Interacting Compasses

    ERIC Educational Resources Information Center

    Riveros, Hector G.; Betancourt, Julian

    2009-01-01

    The use of multiple compasses to map and visualize magnetic fields is well-known. The magnetic field exerts a torque on the compasses aligning them along the lines of force. Some science museums show the field of a magnet using a table with many compasses in a closely packed arrangement. However, the very interesting interactions that occur…

  16. Neutron Background Measurements by the the MSL Dynamic Albedo of Neutrons (DAN) Instrument during the First 360 sols of the Surface Operation at Mars

    NASA Astrophysics Data System (ADS)

    Jun, I.; Mitrofanov, I. G.; litvak, M. L.; Sanin, A.; Behar, A.; Boynton, W. V.; DeFlores, L.; Golovin, D.; Hardgrove, C. J.; Harshman, K.; Kozyrev, A.; Kuzmin, R.; Malakhov, A.; Mischna, M. A.; Moersch, J.; Mokrousov, M.; Nikiforov, S.; Shvetsov, V.; Tate, C.; Vostrukhin, A.; Team, M.

    2013-12-01

    Since first commissioned on sol 3 after landing in August 2012, DAN has been operating successfully and provided a wealth of surface measurement data both in Active mode and in Passive mode operations. Active mode measurements provide a means to determine the characteristics of subsurface in terms of layering structure, content of water equivalent hydrogen (WEH), and/or content of chlorine. Passive mode measurements provide a general background level of low energy (< ~1 keV) neutrons induced by Galactic Cosmic Ray (GCR) interactions with the Martian atmosphere and the surface material and from Multi Mission Radioisotope Thermonuclear Generator (MMRTG). Passive mode measurements have been done on almost every sols with durations ranging from 1 hour to ~9 hour, covering different times of a day. Extensive numerical simulations have been carried out to aid in interpreting the DAN passive data. Both surface operation and numerical simulations show that the passive data correlate very well with the active data. It was also found that the passive data alone could provide a general trend of WEH content variation along the rover traverse. A methodology to estimate the respective contribution from each source (i.e., MMRTG neutrons and GCR-induced neutrons) for the passive data has been developed and was used to understand the neutron background environment at the Rocknest site, where the rover stayed over an extended period of time (from sol 59 to sol 100). The result shows that the MMRTG contribution to the DAN passive counts was about 60% of the total, and the GCR-induced counts were estimated to be about 40%. Details of all these observations, modeling effort, and analysis and interpretation processes will be presented in the final paper by using the passive data collected through sol 360.

  17. Study of the bar{K}-Nucleus Interaction by Using the 12C(K-, p) Reaction at J-PARC

    NASA Astrophysics Data System (ADS)

    Ichikawa, Yudai; Ahn, Jung Keun; Akazawa, Yuya; Aoki, Kanae; Botta, Elena; Ekawa, Hiroyuki; Evtoukhovitch, Petr; Feliciello, Alessandro; Fujita, Manami; Gogami, Toshiyuki; Hasegawa, Shoichi; Hasegawa, Tomoyuki; Hayakawa, Shuhei; Hayakawa, Tomonori; Honda, Ryotaro; Hosomi, Kenji; Imai, Ken'ichi; Jung, Wooseung; Kanatsuki, Shunsuke; Kim, Shinhyung; Kinbara, Shinji; Kobayashi, Kazuya; Lee, Jaeyong; Marcello, Simonetta; Miwa, Koji; Moon, Taejin; Nagae, Tomofumi; Nakada, Yoshiyuki; Nakagawa, Manami; Nanamura, Takuya; Naruki, Megumi; Sakaguchi, Atsushi; Sako, Hiroyuki; Sato, Susumu; Sasaki, Yuki; Shirotori, Kotaro; Sugimura, Hitoshi; Takahashi, Toshiyuki; Tamura, Hirokazu; Tanida, Kiyoshi; Tsamalaidze, Zviadi; Ukai, Mifuyu; Yamamoto, Takeshi. O.

    We have measured the inclusive missing-mass spectrum of the 12C(K-, p) reaction at a K- beam momentum of 1.8 GeV/c. This experiment was carried out as a by-product of a pilot run of the J-PARC E05 experiment, which was conceived to search Ξ-hypernuclei by using the (K-, K+) reaction at J-PARC K1.8 beam line. In present measurement, we study the bar{K}-nucleus interaction by comparing the observed missing-mass spectrum with a DWIA calculation. In a preliminary analysis, a "KINK" structure, which might be originated from the threshold of K-N → Σπ absorption, was found.

  18. Sources X super-Eddington dans les Galaxies Proches

    NASA Astrophysics Data System (ADS)

    Mirioni, L.; Pakull, M. W.

    2001-01-01

    Un certain nombre de galaxies proches abritent, en dehors de leur noyau, des sources X extrêmement lumineuses qui, apparemment dépassent la limite d'Eddington d'un objet compact de quelques masses solaires. Nous avons réalisé une étude photométrique et spectroscopique d'un échantillon de ces sources X brillantes en utilisant pour cela le télescope de 193 cm de l'OHP, le CFHT et le NTT de l'ESO. Ceci nous a permis de mettre en évidence l'association d'une source X avec une nébuleuse hautement ionisée, il s'agit de la première identification optique d'une source X super-Eddington. cette découverte est un argument en faveur de l'existence de trous noirs de plusieurs dizaines de masses solaires dans les systèmes binaires. Nous avons également découvert des nébuleuses annulaires de quelques centaines de parsecs apparemment excitées par les sources X très lumineuses.

  19. [Pharmacokinetic interactions].

    PubMed

    Arazo Garcés, Piedad; de los Santos Gil, Ignacio

    2013-06-01

    Rilpivirine (RPV) is a nonnucleoside reverse transcriptase inhibitor (NNRTI) that has been approved for use in treatment-naïve patients and which has potent antiviral activity. Its adverse effects profile differs from that of first-generation NNRTs. The pharmacological interactions produced by RPV are due to its effects on the CYP450 system; RPV is a substrate and mild inducer of CYP3A4. Moreover, in vitro, RPV inhibits glycoprotein-P. RPV has clinically significant pharmacological interactions, especially with protease inhibitors (except boosted darunavir and lopinavir) and the NNRTIs efavirenz and nevirapine. Coadministration of RPV with drugs that increase gastric pH, such as omeprazole, or those inducing CYP3A4, such as rifampicin, can significantly reduce RPV concentrations and is contraindicated. The concomitant use of RPV with a CYP3A4 inhibitor (such as clarithromycin) can increase RPV concentrations. Administration of PRV with food is recommended to obtain better absorption and adequate plasma values.

  20. Sacroiliites infectieuses dans le centre tunisien: étude rétrospective de 25 cas

    PubMed Central

    Bellazreg, Foued; Alaya, Zeineb; Hattab, Zouhour; Lasfar, Nadia Ben; Ayeche, Mohamed Laziz Ben; Bouajina, Elyes; Letaief, Amel; Hachfi, Wissem

    2016-01-01

    Les sacroiliites infectieuses sont rares mais peuvent se compliquer de séquelles fonctionnelles invalidantes. Décrire les caractéristiques cliniques et bactériologiques des sacroiliites infectieuses chez les patients suivis à Sousse, Centre Tunisien. Etude rétrospective, descriptive, des cas de sacroiliites infectieuses chez les patients hospitalisés à Sousse entre 2000 et 2015. Le diagnostic a été retenu devant des signes cliniques, d'imagerie, et microbiologiques évocateurs. Vingt-cinq patients, 10 hommes et 15 femmes, d’âge moyen 41 ans (19-78) ont été inclus. Les sacroiliites étaient dues à des bactéries pyogènes dans 14 cas (56%), brucelliennes dans 6 cas (24%), et tuberculeuses dans 5 cas (20%). La durée moyenne d’évolution était de 61, 45 et 402 jours respectivement. Les signes cliniques les plus fréquents étaient les douleurs fessières (92%) et la fièvre (88%). La radiographie standard était anormale dans 75% des cas. La TDM et l'IRM sacro-iliaques dans tous les cas. Le diagnostic a été confirmé bactériologiquement dans 24 cas (96%). La durée moyenne d'antibiothérapie était de 83 jours dans les sacroiliites à pyogènes, et de 102 jours dans les SI brucelliennes. L’évolution était favorable chez 12 patients (48%), 9 patients (36%) ont gardé une douleur sacro-iliaque séquellaire, et 4 patients (16%) sont décédés. Dans notre étude, la durée d’évolution de la sacroiliite infectieuse ne permettait pas de prédire la bactérie responsable, d'où la nécessité d'obtenir une documentation bactériologique afin de prescrire une antibiothérapie appropriée. PMID:27583067

  1. Migration pelvienne de broche guide dans la chirurgie des fractures de hanche: à propos de 3 cas

    PubMed Central

    Guèye, Mohamadou Lamine; Thiam, Ousmane; Touré, Alpha Oumar; Seck, Mamadou; Cissé, Mamadou; Kâ, Ousmane; Dieng, Madieng; Dia, Abderahmane; Touré, Cheikh Tidiane

    2015-01-01

    La migration de matériel d'ostéosynthèse est une complication bien connue du traitement chirurgical des fractures. Toutefois, la migration pelvienne de broche guide dans la chirurgie des fractures de la hanche est un incident rare et potentiellement grave. Nous rapportons 3 observations dans lesquelles on notait une migration de broche guide dans le pelvis lors d'une ostéosynthèse dela hanche de type DHS. L'indication chirurgicale était une fracture per-trochantérienne dans 2 cas et une fracture du col fémoral type 4 de Garden dans 1 cas. Une minilaparotomie permettait d'objectiver une plaie du ligament large gauche et un hématome ligamentaire dans 1 cas, tandis que dans les 2 autres cas, il n'y avait pas de lésion viscérale. L'extraction de la broche a été effectuée dans les 3 cas. Les suites opératoires ont été simples chez tous les patients. PMID:26327949

  2. Three dimensional, non-linear, finite element analysis of compactable soil interaction with a hyperelastic wheel

    NASA Astrophysics Data System (ADS)

    Chiroux, Robert Charles

    The objective of this research was to produce a three dimensional, non-linear, dynamic simulation of the interaction between a hyperelastic wheel rolling over compactable soil. The finite element models developed to produce the simulation utilized the ABAQUS/Explicit computer code. Within the simulation two separate bodies were modeled, the hyperelastic wheel and a compactable soil-bed. Interaction between the bodies was achieved by allowing them to come in contact but not to penetrate the contact surface. The simulation included dynamic loading of a hyperelastic, rubber tire in contact with compactable soil with an applied constant angular velocity or torque, including a tow load, applied to the wheel hub. The constraints on the wheel model produced a straight and curved path. In addition the simulation included a shear limit between the tire and soil allowing for the introduction of slip. Soil properties were simulated using the Drucker-Prager, Cap Plasticity model available within the ABAQUS/Explicit program. Numerical results obtained from the three dimensional model were compared with related experimental data and showed good correlation for similar conditions. Numerical and experimental data compared well for both stress and wheel rut formation depth under a weight of 5.8 kN and a constant angular velocity applied to the wheel hub. The simulation results provided a demonstration of the benefit of three-dimensional simulation in comparison to previous two-dimensional, plane strain simulations.

  3. Dynamic Albedo of Neutrons (DAN) Experiment Onboard NASA's Mars Science Laboratory

    NASA Astrophysics Data System (ADS)

    Mitrofanov, I. G.; Litvak, M. L.; Varenikov, A. B.; Barmakov, Y. N.; Behar, A.; Bobrovnitsky, Y. I.; Bogolubov, E. P.; Boynton, W. V.; Harshman, K.; Kan, E.; Kozyrev, A. S.; Kuzmin, R. O.; Malakhov, A. V.; Mokrousov, M. I.; Ponomareva, S. N.; Ryzhkov, V. I.; Sanin, A. B.; Smirnov, G. A.; Shvetsov, V. N.; Timoshenko, G. N.; Tomilina, T. M.; Tret'yakov, V. I.; Vostrukhin, A. A.

    2012-09-01

    The description of Dynamic Albedo of Neutrons (DAN) experiment is presented, as a part of the NASA's Mars Science Laboratory mission onboard the mars rover Curiosity. The instrument DAN includes Pulsing Neutron Generator (PNG) producing pulses of 14.1 MeV neutrons for irradiation of subsurface material below the rover, and Detectors and Electronics (DE) unit, which operates the instrument itself and measures the die-away time profiles of epithermal and thermal neutrons following each neutron pulse. It is shown that the DAN investigation will measure a content of hydrogen along the path of the MSL rover, and it will also provide information about a depth distribution of hydrogen at 10-20 regions selected for the detailed studies and sampling analysis.

  4. The local subsurface water and chlorine distributions evaluated by DAN/MSL in Curiosity observational campaigns

    NASA Astrophysics Data System (ADS)

    Litvak, Maxim; Mitrofanov, Igor; Hardgrove, Craig; Sanin, Anton; Lisov, Denis; Golovin, Dmitry; Jun, Insoo; Kozyrev, Alexander; Malakhov, Alexey; Mischna, Michael; Moersch, Jeffrey; Nikiforov, Sergey; Tate, Cristopher; Vostrukhin, Andrey

    2016-04-01

    The measurements with the Dynamic Albedo of Neutrons (DAN) instrument onboard the Mars Science Laboratory (MSL) Curiosity rover are presented and analyzed as a summary of observations acquired during several special observational campaigns at the Yellowknife Bay area (first discovery of habitability environment), at the striated units of Kimberley formation, at outcrops studied in Pahrump Hills (at the base of Mt Sharp) and in high silica area discovered in Marias Pass (Mudstone facies of the Murray formation). DAN data were analyzed to test local and global variability in the distribution of bulk hydrogen and neutron-absorbing elements, characterized as chlorine-equivalent concentration. Using multi instrument approach in the data analysis we have compared DAN estimations of subsurface H and Cl distributions with inhomogeneity of local geological context, top surface measurements of chlorine with APXS and with SAM measurements of absorbed H2O extracted from the drilled samples based on low temperature evolved gas analysis.

  5. Le pompage optique naturel dans le milieu astrophysique

    NASA Astrophysics Data System (ADS)

    Pecker, J.-C.

    The title of this lecture abstracts only a part of it : the importance in astrophysics of the study of non-LTE situations has become considerable, as well in the stellar atmospheres as, still more, in the study of fortuitous coincidences as a mechanism of formation of emission line nebular spectra, or of molecular interstellar « masers ». Another part of this talk underlines the role of Kastler in his time, and describes his warm personality through his public reactions in front of the nuclear armement, of the Viet-Nam and Algerian wars, of the problems of political refugees... Kastler was a great scientist ; he was also a courageous humanist. 1976 : Les accords nucléaires du Brésil : allocution d'ouverture (19 mars). Colloque sur le sujet ci-dessus. 1976 : La promotion de la culture dans le nouvel ordre économique international, allocution à l'occasion d'une table ronde sur ce thème par l'UNESCO (23-27 juin 1976) ; « Sciences et Techniques », octobre 1976. 1979 : La bête immonde (avec J.-C. Pecker), « Le Matin », 20 mars. 1979 : Appel à nos ministres (avec J.-C. Pecker), « Le Monde », 13 décembre. 1979 : Le flou, le ténébreux, l'irrationnel (avec J.-C. Pecker), « Le Monde », 14 septembre. 1980 : Education à la paix, Préface, in : Publ. UNESCO. 1981 : Le vrai danger, « Le Monde », 6 août 1981. 1982 : Nucléaire civil et militaire, « Le Monde », 1er juin 1982. 1982 : Les scientifiques face à la perspective d'holocauste nucléaire (texte inédit). Le titre de cette communication en résume seulement une partie : l'importance prise en astrophysique par l'analyse des situations hors ETL est devenue considérable, qu'il s'agisse des atmosphères stellaires, ou plus encore, des coïncidences fortuites de la formation des spectres d'émission nébulaires, ou des « masers » moléculaires interstellaires. Une autre partie de cet exposé souligne le rôle de Kastler dans son époque, et décrit sa personnalité généreuse à travers ses r

  6. Sur la reponse en frequence du tissu nerveux dans le cortex

    NASA Astrophysics Data System (ADS)

    Bedard, Claude

    Dans cette These de Physique, nous avons etudie la dependance en frequence du champ electrique du tissu nerveux dans le cortex. Ce champ est aussi designe par "Local field Potential" LFP dans la litterature scientifique. Cette etude est fondee sur la theorie du champ electromagnetisme de Maxwell et sur de l'information tiree de la donne experimentale. Le resultat essentiel de cette These est que la grandeur enorme du temps de relaxation de Maxwell des membranes cellulaires semble etre la cause principale de la dependance en frequence des LFPs. Cette dependance en frequence causee par chaque membrane cellulaire est l'analogue d'un circuit RC ou la resistance R est la resistivite parallele d'une membrane cellulaire, et ou la capacite C est la permittivite electrique de la membrane. L'effet resultant d'un tres grand nombre de cellules donne un spectre de Fourier dont l'enveloppe est tres pres d'un signal en 1/f. Le modele physique propose dans cette These permet de lier les mesures prises a l'interieur d'une dendrite des variations de potentiel electrique a celles prises dans le liquide extracellulaire. De plus, cette These semble ouvrir la possibilite de mesurer le temps de relaxation de Maxwell des membranes cellulaires a l'aide de la mesure de la reponse en frequence du potentiel electrique extracellulaire (LFP). Enfin, cette These permet de lever le voile sur un sujet peu etudie, principalement en raison de la difficulte que represente l'etude des phenomenes electriques dans des milieux complexes comme les tissus vivants. En particulier, le probleme du filtrage frequentiel du potentiel electrique extracellulaire est une propriete fondamentale du tissu nerveux et son origine n'est pas connue.

  7. Instabilités dans les disques d'accrétion des novae naines

    NASA Astrophysics Data System (ADS)

    Buat-Ménard, V.; Hameury, J. M.; Lasota, J. P.

    2001-01-01

    Le caractère éruptif des novae naines provient d'ins- tabilités thermo-visqueuses dans le disque d'accrétion. Le modèle d'instabilité du disque permet de reproduire l'allure des courbes de lumière des novae naines, mais l'examen approfondi de ces dernières fait apparaître plusieurs lacunes. Pour tenter d'améliorer les résultats du modèle, nous y avons inclus des effets de chauffage du disque (tache chaude et effets de marée). Ainsi nous avons pu obtenir des éruptions qui démarrent au bord externe du disque, pour des valeurs du taux de transfert de masse plus cohérentes avec les estimations que dans le cas du modèle standard. En outre, l'ajout de ces effets a permi de reproduire la bimodalité de la distribution des durées des éruptions de certains systèmes comme SS Cygni. Nous avons aussi inclus dans le modèle, une variation du taux de transfert de masse conduisant à la reproduction du phénomène Z Cam. Il est raisonnable de penser qu'une telle fluctuation ait lieu dans la plupart des novae naines. Nous avons, par contre, montré qu'il était très peu probable que des variations de taux de transfert similaires à celles observées dans AM Her, se retrouvent dans les novae naines.

  8. Etude des interdiffusions en phase solide dans le contact Er/GaAs

    NASA Astrophysics Data System (ADS)

    Députier, S.; Guivarc'h, A.; Caulet, J.; Minier, M.; Guérin, R.

    1994-05-01

    Solid state interdiffusions between a thin film of erbium deposited under vacuum conditions and (001) and (111) GaAs substrates were investigated in the temperature range 350-800 ^{circ}C. Complementary analysis methods (RBS, X-ray diffraction) allow us to point out, according to annealing temperatures, successives steps of the interaction corresponding to different mixtures of phases, essentially binaries. These steps are strongly depending on the GaAs substrate orientation, especially the final step of the interdiffusions. On (001) GaAs, only two steps have been observed : no visible interaction is noticed between erbium and GaAs before 600 ^{circ}C ; the interaction begins at 600 ^{circ}C, evolves slightly and leads at 800 ^{circ}C to the nominal composition " Er{10}GaAs " which corresponds to a mixture of several phases Er5Ga3, Er and ErAs. On (111) GaAs, several steps of interaction have been found ; first of all, erbium reacts with the substrate at 400 ^{circ}C (Er5Ga3 + Er mixture), then the reaction is continuing at 600 ^{circ}C (Er5Ga3 + Er + ErAs mixture) before reaching at 800 ^{circ}C the nominal composition " Er{1,5}GaAs ", which is in fact a mixture of the three binaries ErAs + ErGa2 + Er3Ga5. It can be noticed that the 800 ^{circ}C annealing is not sufficient to reach the mixture of the phases ErAs + Ga which, according to the ternary phase diagram, should be the final stage of the interaction Er/GaAs. The analysis of the Er/GaAs interdiffusions shows that ErAs is the " key " compound around which the interaction progresses. This compound appears as an ideal candidate to realize epitaxial ErAs/GaAs heterostructures. Les interdiffusions en phase solide entre une couche mince d'erbium déposée dans des conditions d'ultra-vide et des substrats de GaAs orientés (001) et (111) ont été étudiées après des traitements thermiques d'une heure entre 350 et 800 ^{circ}C. L'utilisation de techniques complémentaires d'analyse (RBS, diffraction X) a permis

  9. Sibling interaction.

    PubMed

    Balsam, Rosemary H

    2013-01-01

    Sibling interactions traditionally were conceived psychoanalytically in "vertical" and parentified oedipal terms and overlooked in their own right, for complicated reasons (Colonna and Newman 1983). Important work has been done to right this, from the 1980s and onward, with conferences and writings. Juliet Mitchell's 2000 and, in particular, her 2003 books, for example, have brought "lateral" sibling relations forcefully to the forefront of insights, especially about sex and violence, with the added interdisciplinary impact of illuminating upheaval in global community interactions as well as having implications for clinicians. A clinical example from the analysis of an adult woman with a ten-years-younger sister will show here how we need both concepts to help us understand complex individual psychic life. The newer "lateral" sibling emphasis, including Mitchell's "Law of the Mother" and "seriality," can be used to inform the older "vertical" take, to enrich the full dimensions of intersubjective oedipal and preoedipal reciprocities that have been foundational in shaping that particular analysand's inner landscape. Some technical recommendations for heightening sensitivity to the import of these dynamics will be offered along the way here, by invoking Hans Loewald's useful metaphor of the analytic situation as theater.

  10. Liants Polyethers et Polyesters dans les Propergols Composites (Polyether and Polyester binders in Composite Propellants),

    DTIC Science & Technology

    1977-03-01

    volumique de caoutchouc r6ticu16 clans le caoutchoucr aonfl6 dans le tolu~ne. VPO tonom~trie ou osmom6trie en phase \\’apeur WLF IWilliams-Landel-Ferry...chauff6 dans tine 6tuve 4 800C jusqu’a duret6 constante du caoutchouc . Apr~s tin temps de cuisson variant entre 7 et 18 jours, on d6termine les...600C, en pr6sence d’ol~ate de chrome, montre que le ERL 4221 (oti CY 179 oti EP 201) nous donne un des meilleurs caoutchoucs parmi tous les 6poxydes

  11. Recruiting and Selection in the French Army (Recrutement et Selection Dans L’Armee Francaise)

    DTIC Science & Technology

    2000-08-01

    armne professionnelle l’origine et l𔃿ge du recrutement; il importe donc appelde A dvoluer dans un aujourd’hui d’adapter notre syst~me de sdlection...de carri~re selon les competences . La rdalisation de cet Une selection m6dicale mininiale (SIGYCOP) est objectif passe par le recrutement dgalement...tests de personnalitd destinds A fonctions d’expert dans sen domaine de 6cartcr les laurdats n’ayant manifestement pas les competence (niveau BAC +5

  12. Cosmic Interactions

    NASA Astrophysics Data System (ADS)

    2008-01-01

    An image based on data taken with ESO's Very Large Telescope reveals a triplet of galaxies intertwined in a cosmic dance. ESO PR Photo 02/08 ESO PR Photo 02/08 NGC 7173, 7174, and 7176 The three galaxies, catalogued as NGC 7173 (top), 7174 (bottom right) and 7176 (bottom left), are located 106 million light-years away towards the constellation of Piscis Austrinus (the 'Southern Fish'). NGC 7173 and 7176 are elliptical galaxies, while NGC 7174 is a spiral galaxy with quite disturbed dust lanes and a long, twisted tail. This seems to indicate that the two bottom galaxies - whose combined shape bears some resemblance to that of a sleeping baby - are currently interacting, with NGC 7176 providing fresh material to NGC 7174. Matter present in great quantity around the triplet's members also points to the fact that NGC 7176 and NGC 7173 have interacted in the past. Astronomers have suggested that the three galaxies will finally merge into a giant 'island universe', tens to hundreds of times as massive as our own Milky Way. ESO PR Photo 02/08 ESO PR Photo 02b/08 NGC 7173, 7174, and 7176 The triplet is part of a so-called 'Compact Group', as compiled by Canadian astronomer Paul Hickson in the early 1980s. The group, which is the 90th entry in the catalogue and is therefore known as HCG 90, actually contains four major members. One of them - NGC 7192 - lies above the trio, outside of this image, and is another peculiar spiral galaxy. Compact groups are small, relatively isolated, systems of typically four to ten galaxies in close proximity to one another. Another striking example is Robert's Quartet. Compact groups are excellent laboratories for the study of galaxy interactions and their effects, in particular the formation of stars. As the striking image reveals, there are many other galaxies in the field. Some are distant ones, while others seem to be part of the family. Studies made with other telescopes have indeed revealed that the HCG 90 group contains 16 members

  13. Electroweak interactions

    SciTech Connect

    Bjorken, J.D.

    1980-10-01

    A point of view of the electroweak interaction is presented. It begins phenomenologically and moves in stages toward the conventional gauge theory formalism containing elementary scalar Higgs-fields and then beyond. The purpose in so doing is that the success of the standard SU(2) x U(1) theory in accounting for low energy phenomena need not automatically imply success at high energies. It is deemed unlikely by most theorists that the predicted W/sup + -/ or Z/sup 0/ does not exist or does not have the mass and/or couplings anticipated in the standard model. However, the odds that the standard predictions will work are not 100%. Therefore there is some reason to look at the subject as one would were he forced by a wrong experimental outcome - to go back to fundamentals and ascertain what is the minimal amount of theory necessary to account for the data.

  14. Designing "Interaction": How Do Interaction Design Students Address Interaction?

    ERIC Educational Resources Information Center

    Karlgren, Klas; Ramberg, Robert; Artman, Henrik

    2016-01-01

    Interaction design is usually described as being concerned with interactions with and through artifacts but independent of a specific implementation. Design work has been characterized as a conversation between the designer and the situation and this conversation poses a particular challenge for interaction design as interactions can be elusive…

  15. Cloud Interactions

    NASA Technical Reports Server (NTRS)

    2004-01-01

    [figure removed for brevity, see original site]

    Released 1 July 2004 The atmosphere of Mars is a dynamic system. Water-ice clouds, fog, and hazes can make imaging the surface from space difficult. Dust storms can grow from local disturbances to global sizes, through which imaging is impossible. Seasonal temperature changes are the usual drivers in cloud and dust storm development and growth.

    Eons of atmospheric dust storm activity has left its mark on the surface of Mars. Dust carried aloft by the wind has settled out on every available surface; sand dunes have been created and moved by centuries of wind; and the effect of continual sand-blasting has modified many regions of Mars, creating yardangs and other unusual surface forms.

    This image was acquired during mid-spring near the North Pole. The linear water-ice clouds are now regional in extent and often interact with neighboring cloud system, as seen in this image. The bottom of the image shows how the interaction can destroy the linear nature. While the surface is still visible through most of the clouds, there is evidence that dust is also starting to enter the atmosphere.

    Image information: VIS instrument. Latitude 68.4, Longitude 258.8 East (101.2 West). 38 meter/pixel resolution.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

    NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration

  16. Diffusion des macromolécules de dextrane dans le gel Séphadex G-200

    NASA Astrophysics Data System (ADS)

    Moussaoui, M.; Hamieh, T.; Toufaily, J.; Naoufal, D.

    2005-05-01

    Dans cet article nous avons étudié la diffusion des macromolécules de dextrane marquées à l'isothiocyanate de fluorescéine (FITC), dans les perles de l'ultrogel AcA34, par la méthode du retour de la fluorescence après photoblanchiment (FRAP). Le coefficient de partage chromatographique (Kc), a été déterminé par chromatographie sur une colonne de l'ultrogel AcA34. Le coefficient de partage microfluorimétrique (Kf) a été déterminé par la technique de (FRAP), en mesurant à la fois, la fluorescence dans la perle et dans le solvant. La relation entre le coefficient de partage chromatographique et le rayon de Stokes (Rs) des macromolécules a été étudiée en appliquant la relation de Laurent et Killender, alors que la variation du coefficient de diffusion relatif D/D0, a été étudiée en fonction de Kc en appliquant la théorie d'Ogston et al.

  17. "Using the Arts To Teach Assia Djebar's "Femmes d'Alger dans leur appartement."

    ERIC Educational Resources Information Center

    Vogl, Mary B.

    2003-01-01

    Offers suggestion son how to use film, paintings, photographs, and music to teach "Femmes d'Alger dans leur appartement," a collection of stories written by one of Algeria's leading intellectuals. Examines how the arts can be used as lenses for revealing the layers of meaning in the stories, and encourages students to examine literary texts from…

  18. Sondes radicalaires pour l'imagerie RPE et PDN stables dans les fluides biologiques

    NASA Astrophysics Data System (ADS)

    Guiberteau, T.; Marx, L.; Rassat, A.; Grucker, D.

    1999-10-01

    Electron paramagnetic resonance and dynamic nuclear polarisation are two techniques that allow the detection of free radicals. They can also be used for in vivo studies for oximetry in blood or tissues. One of the main problems for the development of these techniques is the need of free radicals that are stable in biological media. We present in this communication a study by EPR and DNP of two free radicals that can be suitable for in vivo applications. La résonance paramagnétique électronique et la polarisation dynamique nucléaire sont deux techniques qui permettent de détecter les radicaux libres dans divers systèmes. Elles peuvent également être utilisées in vivo et permettre ainsi de mesurer la concentration en oxygène dans le sang ou dans les tissus. Un des problèmes de ces techniques est l'utilisation de sondes radicalaires suffisamment stables dans les milieux biologiques. Nous présentons une étude comparative par RPE et PDN de deux radicaux libres de type nitroxydes dérivés de l'isoindoline. Un des radicaux possédant quatre groupements éthyle semble être intéressant pour le développement de la RPE et la PDN in vivo.

  19. Southwest Research Institute astronomer Dan Durda checks the alignment of the SWUIS-A Xybion digital

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Southwest Research Institute astronomer Dan Durda checks the alignment of the SWUIS-A Xybion digital camera mounted in the rear cockpit of a NASA Dryden F/A-18B before taking off on an astronomy mission to search for small vulcanoids (asteroids) that may be orbiting between the sun and the planet Mercury.

  20. Harold Goldstein (R) and Dan Leiser (L) discuss bone implant development in the the Shuttle Tile

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Harold Goldstein (R) and Dan Leiser (L) discuss bone implant development in the the Shuttle Tile Laboratory N-242. A spin-off of Ames research on both bone density in microgravity and on thermal protection foams is the bone-growth implant shown in 1993.

  1. An Interview with Dan Hallahan: From Clinical Researcher to Consummate Teacher Educator

    ERIC Educational Resources Information Center

    Sayeski, Kristin L.

    2014-01-01

    Kristin L. Sayeski introduces the reader to Dan Hallahan and provides a synopsis of his educational background. She reports Hallahan received his BA in psychology in 1967 and his PhD in education and psychology in 1971 from the University of Michigan, then began his career as an assistant professor in special education at the University of…

  2. Evaluation acousto-ultrasonique de l'endommagement thermique dans un materiau composite carbone/epoxyde

    NASA Astrophysics Data System (ADS)

    Beland, Sylvie

    1998-12-01

    Les materiaux composites avances a matrice polymerique lorsqu'utilises dans des applications structurales aerospatiales sont souvent exposes a des temperatures tres elevees durant de courtes periodes de temps. Ces expositions thermiques peuvent affecter de facon significative leurs proprietes mecaniques. Cette degradation des proprietes suite a la surchauffe est un probleme qui souleve de plus en plus d'inquietude au sein de la communaute aerospatiale. On s'interesse tout autant a la caracterisation de l'endommagement resultant de l'exposition thermique qu'a son evaluation non-destructive. Bien que la technique acousto-ultrasonique semble etre une technique d'evaluation non-destructive toute indiquee pour la detection et la caraterisation de l'endommagement thermique dans les composites avances, il semblerait qu'on ne l'ait pas encore exploitee en ce sens. Cette lacune combinee a l'engagement du Ministere canadien de la defense nationale a developper une technique d'evaluation non-destructive in-situ de l'endommagement thermique de structures composites dans certains avions de chasse de la flotte canadienne constituent la motivation majeure de ce projet de recherche. Cette etude evalue la capacite de la technique acousto-ultrasonique a detecter et quantifier l'endommagement subi par un materiau composite suite a une exposition thermique. Pour parvenir a cet objectif, l'approche de cette etude a ete principalement de nature experimentale. Dans ce contexte, une base importante de donnees acousto-ultrasoniques a ete generee sur des materiaux composites vierges et conditionnes dans le but de correler ces donnees a celles issues des essais mecaniques et des analyses micrographiques et fractographiques. L'evaluation acousto-ultrasonique de la degradation thermique a ete realisee sur des echantillons de resine pure et de composite ayant ete expose a divers conditionnements. De plus, l'evolution de l'endommagement dans des composites vierges et degrades thermiquement a ete

  3. Les Reseaux de Bragg dans la Fibre Optique et leurs Applications

    NASA Astrophysics Data System (ADS)

    Lauzon, Jocelyn

    Dans les systemes de communications optiques actuels, la fibre optique ne constitue qu'un canal de transmission. L'amplification des signaux transmis ainsi que les decisions les concernant, comme la commutation, se font electroniquement. La conversion des signaux optiques en signaux electroniques (et vice versa) est couteuse et d'efficacite restreinte. Il est donc necessaire pour les chercheurs de trouver des strategies qui permettraient de transmettre le signal d'un bout a l'autre de la ligne sous forme optique. Deja, des amplificateurs a fibre existent pour repondre au premier probleme; il reste a trouver une maniere tout-optique de prendre des decisions par rapport au signal transmis. L'utilisation de filtres passifs, hautement selectifs en longueur d'onde et inscrits directement dans la fibre optique, est une solution elegante pour repondre a ce second probleme. Les reseaux de Bragg dans la fibre optique correspondent a cette description: nous avons donc decide de les etudier de facon rigoureuse. Nous avons d'abord tente de mieux comprendre la reaction photosensible provoquant l'inscription de ce genre de dispositif dans certaines fibres optiques. Ensuite, une nouvelle methode d'inscription de reseaux de Bragg dans la fibre optique a ete elaboree et caracterisee. Finalement, certaines applications des reseaux que nous avons inscrits ont ete proposees. L'etude de la reaction photosensible a ete faite indirectement, a l'aide de phenomenes provoques par celle -ci: la photoluminescence, l'attenuation photo-induite et les changements d'indice photo-induits. L'observation de ces phenomenes nous a permis de developper un modele sommaire, expliquant en partie la reaction photosensible. Le montage d'ecriture des reseaux de Bragg dans la fibre optique nous a permis d'observer la nature quasi -isotrope du changement d'indice photo-induit. La qualite des reseaux de Bragg inscrits a l'aide de ce montage a ete evaluee. Le montage nous a aussi permis de demontrer que la

  4. L'atteinte osseuse dans le sarcome de Kaposi classique et agressif: à propos d'un cas

    PubMed Central

    Sbiyaa, Mouhcine; El Alaoui, Adil; El Bardai, Mohammed; Mezzani, Amine; Lahrach, Kamal; Marzouki, Amine; Boutayeb, Fawzi

    2016-01-01

    Le sarcome de Kaposi classique est une tumeur rare multifocale d'origine des cellules endothéliales vasculaires à caractère évolutif progressif et peu maligne. L'atteinte viscérale dans le sarcome de kaposi est parfois observée chez les patients VIH positif par contre la dissémination tumorale dans les ganglions lymphatiques viscérales dans le SK classique reste très rare. On rapporte un cas rare de sarcome de kaposi classique agressif de la main avec une évolution rapide et destructive. PMID:27347285

  5. Observation of Very High Passive Mode Thermal Neutron Counts by the MSL DAN Instrument at Marias Pass in Gale Crater

    NASA Astrophysics Data System (ADS)

    Jun, I.; Mitrofanov, I. G.; Litvak, M. L.; Sanin, A. B.; Martinez Sierra, L. M.; Frydenvang, J.; Fedosov, F.; Golovin, D.; Hardgrove, C. J.; Harshman, K.; Kozyrev, A.; Malakhov, A. V.; Mischna, M. A.; Moersch, J.; Mokrousov, M.; Nikiforov, S.; Tate, C. G.

    2015-12-01

    Since landing in August 2012, DAN has provided a wealth of scientific data from the successful surface operation in both Active mode and Passive mode. The main scientific objectives of DAN are twofold. The primary objective is to measure the bulk hydrogen abundance (in forms of water or hydrated minerals) of the subsurface. The secondary objective is to measure the background neutron environment at the surface. DAN achieves the first objective by using the pulsed neutron generator (PNG) as a pulsed 14 MeV neutron source (active mode). When no neutron pulse is used (passive mode), DAN measures the neutron background environment at the Martian surface. The DAN active data have extensively and successfully used in estimating the near-surface contents of hydrogen (in terms of "water equivalent hydrogen" or WEH) and chlorine (in terms of "absorption equivalent chlorine" or AEC) at multiple locations in Gale crater. In the mean time, DAN has been accumulating the passive mode data in almost all sols since landing, and it is the main topic of this presentation. Particularly, we want to show the DAN data on Sol 991 and 992 where we observed very high passive thermal neutron count - a factor of ~2 higher than usual count. As a reminder, note that many different factors would influence the amplitude of DAN passive thermal neutron counts - GCR condition, soil compositions, water/chlorine contents, etc. The Sol 991/992 location, which is at a region near a rock target called Elk in Marias Pass, was also analyzed by another MSL instrument ChemCAM. And interestingly, its data show that the Elk target is estimated to contain as high as 80 wt% of SiO2, which is radically different from what we have used as a reference soil composition for the interpretation of the DAN passive data. This means that the DAN passive data simulations have to be revisited to account for different soil composition data at the Elk target region. In the final presentation, we will present new simulation

  6. Methodologies nouvelles pour la realisation d'essais dans la soufflerie Price-Paidoussis

    NASA Astrophysics Data System (ADS)

    Flores Salinas, Manuel

    Le present memoire en genie de la production automatisee vise a decrire le travail effectue dans la soufflerie Price-Paidoussis du laboratoire LARCASE pour trouver les methodologies experimentales et les procedures de tests, qui seront utilisees avec les modeles d'ailes actuellement au laboratoire. Les methodologies et procedures presentees ici vont permettre de preparer les tests en soufflerie du projet MDO-505 Architectures et technologies deformables pour l'amelioration des performances des ailes, qui se derouleront durant l'annee 2015. D'abord, un bref historique des souffleries subsoniques sera fait. Les differentes sections de la soufflerie Price-Paidoussis seront decrites en mettant l'emphase sur leur influence dans la qualite de l'ecoulement qui se retrouve dans la chambre d'essai. Ensuite, une introduction a la pression, a sa mesure lors de tests en soufflerie et les instruments utilises pour les tests en soufflerie au laboratoire LARCASE sera presente, en particulier le capteur piezoelectrique XCQ-062. Une attention particuliere sera portee au mode de fonctionnement, a son installation, a la mesure et a la detection des frequences et aux sources d'erreurs lorsqu'on utilise des capteurs de haute precision comme la serie XCQ-062 du fournisseur Kulite. Finalement, les procedures et les methodologies elaborees pour les tests dans la soufflerie Price-Paidoussis seront utilisees sur quatre types d'ailes differentes. L'article New methodology for wind tunnel calibration using neural networks - EGD approch portant sur une nouvelle facon de predire les caracteristiques de l'ecoulement a l'interieur de la soufflerie Price-Paidoussis se trouve dans l'annexe 2 de ce document. Cet article porte sur la creation d'un reseau de neurones multicouche et sur l'entrainement des neurones, Ensuite, une comparaison des resultats du reseau de neurones a ete fait avec des valeurs simules avec le logiciel Fluent.

  7. Evaluation de l'intergiciel de communication DDS pour son utilisation dans le domaine avionique

    NASA Astrophysics Data System (ADS)

    Levesque-Landry, Kevin

    Les aeronefs modernes doivent combler de plus en plus de fonctionnalites afin de satisfaire les besoins de la clientele. De ce fait, les besoins en communications des systemes avioniques sont grandissants. De plus, la portabilite et la reutilisabilite des applications sont des defis d'actualite dans le domaine avionique. De ce fait, ce projet de recherche vise a faire une evaluation de la technologie d'intergiciel de service de distribution de donnees (DDS) pour son utilisation dans le domaine avionique. Cette technologie permettrait de reduire la complexite des communications et faciliter la portabilite et reutilisabilite des applications grâce a son interface standardisee. Dans ce projet de recherche, la norme DDS est tout d'abord etudiee pour cibler les fonctionnalites qui sont utiles au domaine avionique. Les differentes polices de qualite de services sont ainsi etudiees et denotent la flexibilite de la technologie DDS. Un intergiciel DDS est egalement evalue dans un environnement de laboratoire afin de mesurer l'impact de l'utilisation de cette technologie sur les performances de latence ainsi que sur l'utilisation de la bande passante. Les resultats montrent une faible augmentation de la latence moyenne lorsque l'intergiciel DDS est utilise. L'intergiciel DDS est egalement utilise dans une etude de cas avec un AFCS (automatic flight control system) afin de quantifier les effets de son utilisation sur une application avionique. Les resultats montrent que l'utilisation de l'intergiciel DDS n'empeche pas l'AFCS d'atteindre la stabilite, mais qu'elle ralentit l'atteinte de cette derniere. Finalement, une etude de cas est effectuee afin de valider que la technologie DDS peut etre utilisee pour construire des systemes redondants. Les resultats montrent que l'intergiciel DDS permet de faire de la redondance de reserve sans avoir un impact visible sur les performances du systeme redondant.

  8. Simulation numérique d'écoulement compressible dans les joints labyrinthe

    NASA Astrophysics Data System (ADS)

    Sriti, M.; Agouzoul, M.; Ouazar, D.; Micheau, P.

    1997-05-01

    The labyrinth seals are the devices used machines which serve to restrict the leakages crossing a carter (or stator) by a rotating shaft (or rotor) and to avoid the important friction to high rotation speeds. These devices, which in addition behave as shaft bearings, can modify the dynamics characteristics of the line of the shaft in which they are integrated. The present work has been carried out with the purpose of controlling better the flows within the labyrinth seals and to determine their static (leakage-pressure) and dynamic (stiffness and damping coefficients) characteristics. It's based on the development of a global numerical model, and on the integration of the obtained correlations by 3D axisymmetric computation in this model. Les joints labyrinthe sont des dispositifs utilisés dans les machines, ils servent à limiter les fuites à la traversée d'un carter (ou stator) par un arbre tournant (ou rotor) et éviter le frottement important aux vitesses de rotation élevées. Ces dispositifs, qui de plus, se comportent comme des paliers, peuvent modifier les caractéristiques dynamiques de la ligne d'arbre dans laquelle ils sont intégrés. Le travail présenté a été effectué dans le but de mieux maîtriser les écoulements dans les joints labyrinthe et de déterminer leurs caractéristiques statiques (débit-pression) et dynamiques (coefficients de raideur et d'amortissement). Il s'appuie sur le développement d'outils numériques intégrant dans les calculs globaux des résultats de calculs locaux (3D axisymétriques).

  9. Materials Data on KN3 (SG:140) by Materials Project

    SciTech Connect

    Kristin Persson

    2016-04-22

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  10. Place de la bili-IRM dans le diagnostic etiologique des icteres cholestatiques à Dakar

    PubMed Central

    Badji, Nfally; Akpo, Geraud; Deme, Hamidou; Toure, Mouhamadou Hamine; Ly, Mamadou; Ndong, Boucar; Niang, El Hadji

    2016-01-01

    La Bili-IRM est une méthode diagnostique d’introduction relativement récente dans l’arsenal d’exploration de la pathologie bilio-pancréatique. Il s’agit d’une technique fiable reproductible et non invasive, permettant la visualisation directe des voies biliaires et pancréatiques. Le but de ce travail était d’étudier les aspects morphologiques des principales anomalies et d’évaluer la place de la bili-IRM dans le diagnostic étiologique des ictères cholestatiques. Il s’agit d’une étude rétrospective réalisée sur 4 ans et six mois (Janvier 2008 à Juillet 2012) portant sur 17 patients colligés dans les services d’imagerie médicale du CHUN de Fann et de l’hôpital Principal de Dakar. Tous les patients ont bénéficié d’une IRM (1,5T) avec des protocoles adaptés en fonction de la pathologie explorée. Les dossiers retenus sont ceux dont le diagnostic a été établi à partir du bilan biologique et ayant bénéficié à la fois d’une bili-IRM et d’une exploration chirurgicale. Il s’agissait de 05 femmes et de 12 hommes soit un sexe ratio de 2.4. L’âge moyen des patients était de 58 ans avec des extrêmes de 35 et 81 ans. Les tumeurs de Klatskin étaient observées chez 07 patients avec une forme infiltrante dans 71% des cas et une forme exophytique dans 28% des cas. Les cancers de la vésicule biliaire étaient notés dans 28% des cas. Les cancers de la tête du pancréas représentaient 28% des cas. La lithiase de la voie biliaire principale était présente chez 05 patients avec un empierrement cholédocien dans 60% des cas et une lithiase unique dans 40% des cas. Toutes ces lésions étaient responsables d’une dilatation des VBIH. Un cas de dilatation des voies biliaires intra et extra hépatiques était retrouvé sans cause bilio-pancréatique. La bili-IRM est l’examen de choix dans l’exploration des ictères cholestatiques. Elle doit être demandée en première intention lorsqu’on suspecte une lithiase r

  11. Apport des moyens endoscopiques dans la dilatation des sténoses caustiques de l’œsophage

    PubMed Central

    Seydou, Togo; Abdoulaye, Ouattara Moussa; xing, Li; Zi, Sanogo Zimogo; sekou, Koumaré; Wen, Yang Shang; Ibrahim, Sankare; Sekou, Toure Cheik Ahmed; Boubacar, Maiga Ibrahim; Saye, Jacque; Jerome, Dakouo Dodino; Dantoumé, Toure Ousmane; Sadio, Yena

    2016-01-01

    Introduction Toutes les sténoses symptomatiques de l’œsophage peuvent être dilatées par voie endoscopique. Nous évaluons l'apport des moyens endoscopiques dans la prise en charge de la dilatation œsophagienne pour sténose caustique de l’œsophage (SCO) au Mali. Méthodes IL s'agissait d'une étude descriptive et prospective réalisée dans le service de chirurgie thoracique à l'hôpital du Mali. Au total 46 dossiers cliniques de patients on été enregistrés et subdivisés en 4 groupes en fonction de la topographie des lésions cicatricielles. Le nombre de cas d'assistance endoscopique réalisé a été déterminé afin de comprendre l'apport des moyens endoscopiques dans le succès de la dilatation des SCO. Pour les 2 différentes méthodes de dilatation utilisées, le résultat du traitement et le coût ont comparés. Résultats La FOGD a été utilisée dans 19 cas (41.30%) de dilatation avec la bougie de Savary Guillard et dans 47.82% des cas dans la dilatation de Lerut. La vidéo-laryngoscopie a été utilisé 58.69% des cas de dilatation à la bougie de Lerut. Le passage de guide métallique et / ou de fil-guide a été réalisée dans 39.13% avec la vidéo laryngoscopie et dans 58.68% avec la FOGD. Dans la comparaison des deux méthodes, il existe une différence significative dans la survenue des complications (p=0.04075), l'anesthésie générale (p=0.02287), l'accessibilité à la méthode (p=0.04805) et la mortalité (p=0.00402). Conclusion La SCO est une pathologie grave et sous évaluée au Mali. Les moyens endoscopiques contribuent considérablement au succès de la dilatation œsophagienne pour sténose caustique dans les différentes méthodes utilisées. PMID:27200129

  12. Rôle des hyrates dans la formation de Titan et des satellites réguliers

    NASA Astrophysics Data System (ADS)

    Mousis, O.

    2001-12-01

    Cette these est dediee a l'etude de l'origine de Titan et de son atmosphere. Dans l'hypothese ou la subnebuleuse de Saturne etait geometriquement mince, le modele de disque turbulent utilise, derive des travaux de Dubrulle (1993), est moins dense que le modele de Prinn et Fegley (1981). De ce fait, les conversions de Co en CH4 et de N2 en NH3 ont ete inhibees dans la subnebuleuse, contrairement a ce qui est couramment admis pour interpreter la presence du methane dans l'atmosphere de Titan. C'est pourquoi nous avons developpe un nouveau scenario de la formation de titan, qui tient compte simultanement des contraintes resultant de la chimie de la subnebuleuse et des abondances de CH4, N2 et CH3D mesurees dans l'atmosphere du satellite. Nous faisons l'hypothese que ces gaz proviennent initialement de la vaporisation du nuage presolaire, qui s'effondra et forma le Soleil et son disque environnant. Lors du refroidissement de la nebuleuse, les volatils auraient ete pieges sous formes de clathrates d'hydrates dans les grains, puis dans les planetesimaux qu'ils formerent. Les planetesimaux hydrates a l'origine de la formation de Titan seraient alors des rescapes de l'effondrement hydsrodynamique de la feeding zone de Saturne. Ce scenario a ete applique aux subnebuleuses de Jupiter et d'Uranus, et a apporte un certain nombre de contraintes sur la formation des satellites reguliers de ces planetes. Le temps et la zone de formation des grains cometaires ont egalement ete estimes dans la nebuleuse solaire. Enfin, l'etude experimentale de la temperature de fusion du dihydrate d'ammoniac dans la gamme des hautes pressions a apporte des nouvelles donnees thermodynamiques qui permettront d'ameliorer les modeles de l'interieur de Titan.

  13. Conductivite dans le modele de Hubbard bi-dimensionnel a faible couplage

    NASA Astrophysics Data System (ADS)

    Bergeron, Dominic

    Le modele de Hubbard bi-dimensionnel (2D) est souvent considere comme le modele minimal pour les supraconducteurs a haute temperature critique a base d'oxyde de cuivre (SCHT). Sur un reseau carre, ce modele possede les phases qui sont communes a tous les SCHT, la phase antiferromagnetique, la phase supraconductrice et la phase dite du pseudogap. Il n'a pas de solution exacte, toutefois, plusieurs methodes approximatives permettent d'etudier ses proprietes de facon numerique. Les proprietes optiques et de transport sont bien connues dans les SCHT et sont donc de bonne candidates pour valider un modele theorique et aider a comprendre mieux la physique de ces materiaux. La presente these porte sur le calcul de ces proprietes pour le modele de Hubbard 2D a couplage faible ou intermediaire. La methode de calcul utilisee est l'approche auto-coherente a deux particules (ACDP), qui est non-perturbative et inclue l'effet des fluctuations de spin et de charge a toutes les longueurs d'onde. La derivation complete de l'expression de la conductivite dans l'approche ACDP est presentee. Cette expression contient ce qu'on appelle les corrections de vertex, qui tiennent compte des correlations entre quasi-particules. Pour rendre possible le calcul numerique de ces corrections, des algorithmes utilisant, entre autres, des transformees de Fourier rapides et des splines cubiques sont developpes. Les calculs sont faits pour le reseau carre avec sauts aux plus proches voisins autour du point critique antiferromagnetique. Aux dopages plus faibles que le point critique, la conductivite optique presente une bosse dans l'infrarouge moyen a basse temperature, tel qu'observe dans plusieurs SCHT. Dans la resistivite en fonction de la temperature, on trouve un comportement isolant dans le pseudogap lorsque les corrections de vertex sont negligees et metallique lorsqu'elles sont prises en compte. Pres du point critique, la resistivite est lineaire en T a basse temperature et devient

  14. Modelisation de la Propagation des Ondes Sonores dans un Environnement Naturel Complexe

    NASA Astrophysics Data System (ADS)

    L'Esperance, Andre

    Ce travail est consacre a la propagation sonore a l'exterieur dans un environnement naturel complexe, i.e. en presence de conditions reelles de vent, de gradient de temperature et de turbulence atmospherique. Plus specifiquement ce travail comporte deux objectifs. D'une part, il vise a developper un modele heuristique de propagation sonore (MHP) permettant de prendre en consideration l'ensemble des phenomenes meteorologiques et acoustiques influencant la propagation du son a l'exterieur. D'autre part, il vise a identifier dans quelles circonstances et avec quelle importance les conditions meteorologiques interviennent sur la propagation sonore. Ce travail est divise en cinq parties. Apres une breve introduction identifiant les motivations de cette etude (chapitre 1), le chapitre 2 fait un rappel des travaux deja realises dans le domaine de la propagation du son a l'exterieur. Ce chapitre presente egalement les bases de l'acoustique geometrique a partir desquelles ont ete developpees la partie acoustique du modele heuristique de propagation. En outre, on y decrit comment les phenomenes de refraction et de turbulence atmospherique peuvent etre consideres dans la theorie des rayons. Le chapitre 3 presente le modele heuristique de propagation (MHP) developpe au cours de cet ouvrage. La premiere section de ce chapitre decrit le modele acoustique de propagation, modele qui fait l'hypothese d'un gradient de celerite lineaire et qui est base sur une solution hybride d'acoustique geometrique et de theorie des residus. La deuxieme section du chapitre 3 traite plus specifiquement de la modelisation des aspects meteorologiques et de la determination des profils de celerite et des index de fluctuation associes aux conditions meteorologiques. La section 3 de ce chapitre decrit comment les profils de celerite resultants sont linearises pour les calculs dans le modele acoustique, et finalement la section 4 donne les tendances generales obtenues par le modele. Le chapitre 4 decrit

  15. Geochemistry of dissolved trace elements and heavy metals in the Dan River Drainage (China): distribution, sources, and water quality assessment.

    PubMed

    Meng, Qingpeng; Zhang, Jing; Zhang, Zhaoyu; Wu, Tairan

    2016-04-01

    Dissolved trace elements and heavy metals in the Dan River drainage basin, which is the drinking water source area of South-to-North Water Transfer Project (China), affect large numbers of people and should therefore be carefully monitored. To investigate the distribution, sources, and quality of river water, this study integrating catchment geology and multivariate statistical techniques was carried out in the Dan River drainage from 99 river water samples collected in 2013. The distribution of trace metal concentrations in the Dan River drainage was similar to that in the Danjiangkou Reservoir, indicating that the reservoir was significantly affected by the Dan River drainage. Moreover, our results suggested that As, Sb, Cd, Mn, and Ni were the major pollutants. We revealed extremely high concentrations of As and Sb in the Laoguan River, Cd in the Qingyou River, Mn, Ni, and Cd in the Yinhua River, As and Sb in the Laojun River, and Sb in the Dan River. According to the water quality index, water in the Dan River drainage was suitable for drinking; however, an exposure risk assessment model suggests that As and Sb in the Laojun and Laoguan rivers could pose a high risk to humans in terms of adverse health and potential non-carcinogenic effects.

  16. La modelisation mathematique dans l'enseignement de la chimie des gaz a des eleves de la cinquieme annee du secondaire

    NASA Astrophysics Data System (ADS)

    Gauthier, Diane

    Les problemes d'enseignement de la chimie des gaz parfaits sont donc importants. Si plusieurs etudes ont ete realisees dans le but d'identifier et d'interpreter ces problemes, aucune recherche, a notre connaissance, n'a ete realisee sur l'enseignement des lois sur les gaz parfaits. Notre recherche sur l'enseignement est donc pionniere. Elle a pour objectif general de construire et d'analyser une sequence d'enseignement de la chimie des gaz comportant diverses situations de modelisation mathematique des conduites des gaz. Les principaux objectifs specifiques sont les suivants: (1) identifier et caracteriser les situations qui provoquent une evolution des conceptions naives des eleves, evolution vers des connaissances plus adequate sur les gaz; (2) identifier et caractEriser les situations qui provoquent une evolution des connaissances mathematiques des eleves leur permettant d'interpreter convenablement les resultats des experiences, d'eprouver leurs conceptions, de donner un sens aux notions et aux relations impliquees dans les lois des gaz parfaits, lois de Boyle-Mariotte et Gay-Lussac. Une sequence d'enseignement comportant huit situations est d'eleves de secondaire V. La construction de ces situations est orientee par les recherches sur les conceptions naives des eleves, par les etudes sur l'evolution historique des conceptions sur les gaz et des pratiques scientifiques, ainsi que par les etudes theoriques et empiriques realisees en didactique des sciences et des mathematiques. La methodologie de l'ingenierie didactique (Artigue, 1998) qui constitue une application de la theorie des situations didactiques (Brousseau, 1986) est utilisee dans la construction et l'analyse des situations d'enseignement. Une analyse a priori de chacune des situations d'enseignement est effectuee; elle a pour but dexpliquer les choix des taches qui font partie des situations et de preciser la gestion didactique des situations. Diverses situations d'enseignement de la chimie ont ainsi

  17. Les effets du travail en equipe dans l'apprentissage par projets sur la motivation des etudiantes et des etudiants en formation des ingenieurs

    NASA Astrophysics Data System (ADS)

    Fernandez, Nicolas

    Les representants des secteurs industriels et les, milieux professionnels en Amerique du Nord reprochaient aux universites de former des ingenieurs avec peu d'experience pratique en resolution de problemes et en conception. Quelques programmes de genie ont alors mis en place le travail en equipe dans l'apprentissage par projets. Beaucoup d'ecrits font valoir les benefices de l'apprentissage par projets sur la motivation des etudiants. Or, ces benefices commencent a peine a faire l'objet de recherches visant a produire des donnees probantes a ce sujet. Les travaux sur la motivation en contexte d'apprentissage et les modeles theoriques developpes sont issus d'environnements d'apprentissage marques par l'enseignement magistral. Le modele de la valeur attendue de la tache (Eccles et Wigfield, 1995; Neuville, 2004) et le modele du systeme-groupe (St-Arnaud, 2008) ont ete retenus pour mesurer les effets du travail en equipe dans l'apprentissage par projets sur la motivation. La recherche visait aussi a approfondir et a nuancer la comprehension de la motivation des etudiants universitaires apprenant en contexte innovant. Les sujets constituent des etudiants (n=100) travaillant sur des projets d'integration au cours des trois sessions initiales du programme de genie mecanique d'une universite canadienne. L'analyse de regression multiple revele que les construits de la motivation expliquent un tiers de la variance de l'engagement academique dans la realisation du projet d'integration. Les perceptions de l' "expectancy", de la valeur intrinseque et utilitaire sont les determinants principaux de l'engagement des etudiants. L'analyse de variance multivariee a mesures repetees indique que la motivation des etudiants pour le travail sur les projets d'integration a augmente au cours des trois sessions initiales du parcours de formation. Finalement, malgre l'absence d'interaction significative entre les variables de motivation et de l'equipe, les reponses des sujets indiquent une

  18. Formation et interaction (Teacher Education and Interaction).

    ERIC Educational Resources Information Center

    Bertocchini, Paola; Costanzo, Edwige

    1989-01-01

    Effective interaction is as important in inservice education programs for language teachers as it is in the foreign language classroom. Techniques are described for improving the quality of interaction in teacher workshops through simulation exercises. (MSE)

  19. Dan Olweus: Award for Distinguished Contributions to the International Advancement of Psychology.

    PubMed

    2011-11-01

    Presents Dan Olweus, the 2011 winner for the American Psychological Association Award for Distinguished Contributions to the International Advancement of Psychology. "For his lifelong commitment to understand bullying among children and create safe and humane school settings. Dan Olweus led the education of the global public about the nature and prevalence of bullying, its often serious consequences, and the behavior of adults that allows bullying to occur. He has done so as a careful researcher, a thoughtful theoretician, a creative program developer, and a tireless advocate. He uncovered the problem and created and evaluated a comprehensive solution. Throughout his career, he has been guided by a concern for careful psychological inquiry and a commitment to the promotion of human rights." (PsycINFO Database Record (c) 2011 APA, all rights reserved).

  20. Dan Olweus: Award for Distinguished Contributions to Research in Public Policy.

    PubMed

    2012-11-01

    Presents a short biography of the winner of the American Psychological Association's Award for Distinguished Contributions to Research in Public Policy. The 2012 winner is Dan Olweus for his rigorous scientific research on bullying among children and youth and his early and tireless attention to its public policy implications. Dan Olweus's research on the nature, prevalence, and consequences of bullying and his work to develop and disseminate an evidence-based prevention program provide a model of excellence in the field. His work has played a vital role in the dramatic changes that have occurred in many countries in recent years-from viewing bullying as a normative and accepted part of life at school to recognizing bullying as a pressing public health issue. Olweus's Award citation and a selected bibliography are also presented.

  1. Human Dimensions in Embedded Virtual Simulation (Les dimensions humaines dans la simulation virtuelle integree)

    DTIC Science & Technology

    2009-10-01

    communications techniques et les discussions qui ont suivi ont conduit aux généralisations ci-dessous : • Certaines des applications les plus...FCS et F-35, tous deux ayant expressément nécessité l’inclusion d’une formation intégrée dans leurs projets de conception globale. • La formation des

  2. Progress in Military Airlift (Les Progres Realises dans le Domaine du Transport Aerien Militaire)

    DTIC Science & Technology

    1991-05-01

    300 S ECTE flJ UN 2 7 1991 411 Technical Evaluation Report C on the Flight Mechanics Panel Symposium on Progress in Military Airlift (Les Progres...been reproduced directly from material supplied by AGARD or the authors. Published May 1991 Copyright C AGARD 1991 All Rights Reserved ISBN 92-835-0619-7...fournit des commentaires appropri~s, c -- tire les conclusions qui s’imposent et soumet des recommondations concernant des activit~s futures dans ce

  3. The Dynamic Albedo of Neutrons (DAN) Experiment for NASA Mars Science Laboratory

    NASA Astrophysics Data System (ADS)

    Litvak, Maxim; Mitrofanov, Igor; Kozyrev, S. Alexander; Boynton, William V.; Malakhov, Alexey; Mokrousov, Maxim; Varenikov, Alexey; Vostrukhin, Andrey; Golovin, Dmitrij; Behar, Alberto

    We present a summary of the physical principles, design and results of first tests of the Dynamic Albedo of Neutrons (DAN) instrument onboard NASA's 2009 Mars Science Laboratory (MSL) mission. This instrument will use the method of neutron-neutron activation analysis in a space application to study the abundance and depth distribution of water in Martian subsurface along the path of the MSL rover.

  4. Anisotropie des coefficients de diffusion dans des cristaux liquides discotiques hexagonaux

    NASA Astrophysics Data System (ADS)

    Daoud, M.; Gharbia, M.; Gharbi, A.

    1994-06-01

    The diffusion constants of dyes in several hexagonal discotic liquid crystals are measured and discussed. For all the liquid crystals studied, these constants are anisotropic : the diffusion in the direction parallel to the columns is faster than that in the perpendicular plane (frac{D_allel}{D_perp}>1). The effects of the length and shape of the chains bound to the triphenylene discs are shown. The effect of the dye molecular size is also described. The study of the diffusion coefficients of hexapentoxytriphenylene (C5HET) as a function of temperature has shown that the activation energies along the columns and perpendicular to the columns are comparable. The main features of dye diffusion in the hexagonal columnar liquid crystals studied are similar to those reported in nematic phases. Les mesures des constantes de diffusion de colorants dans plusieurs cristaux liquides discotiques hexagonaux sont présentées et discutées. Pour tous les cristaux liquides étudiés, ces constantes présentent une anisotropie, avec une diffusion plus rapide parallèlement aux colonnes que perpendiculairement à celles-ci (frac{D_allel}{D_perp}>1). Des effets de longueur et de forme des chaînes branchées sur les disques de triphénylène sont mis en évidence. Il en est de même pour la taille des molécules de colorants. L'étude en fonction de la température a montré que dans le cas de l'hexapentoxytriphénylène (C5HET), les énergies d'activation dans les directions parallèle et perpendiculaire aux colonnes sont comparables. Les caractéristiques de la diffusion de colorants dans les cristaux liquides colonnaires hexagonaux étudiés sont semblables à celles des nématiques.

  5. Franz Xaver von Zach et l'astronomie dans la France méridionale

    NASA Astrophysics Data System (ADS)

    Brosche, Peter; Débarbat, Suzanne

    Le baron Franz Xaver von Zach, né à Pest (Hongrie), a fait ses études notamment en France et en Angleterre. En 1786 le duc de Saxe-Gotha, Ernst II, lui demande de créer son observatoire de Seeberg. La même année ils se rendent dans le sud de la France, à Hyères à cette occasion, une des tours du mur d'enceinte de la ville est transformée en observatoire. En 1809, Zach et la duchesse régnante viennent près de Marseille et, lors de plusieurs voyages dans le sud de la France. Zach exécute des travaux géodésiques et astronomiques. Dans son "Journal", il mentionne les astronomes français, notamment ceux de la France méridonale auxquels il apporte son soutien. Pons devient, sur sa recommandation, astronome royal de la duchesse de Lucca, épouse du "roi d'Etrurie".

  6. Bistabilité optique dans un laser à absorbant saturable trimode

    NASA Astrophysics Data System (ADS)

    Djabi, S.; Djabi, M.; Benkherourou, O.

    2005-10-01

    Cettte étude est consacrée à l'élaboration d'un modéele mathématique simple pour décrire l'action des lasers à absorbants saturables, l'approche envisage ici tient compte d'une manière phénoménologique des processus physiques essentiels qui permet de dégager les principaux paramètres physiques dans les LSA et leurs influences sur la bistabilité optique. Nous allons étudier théoriquement la bistabilité optique dans les lasers à absorbants saturables trimodes dans le cas où les deux milieux actif et absorbant subissent un élargissement homogène. Nous avons établi un programme permettant de déterminer l'effet de la bistabilité optique, de tracer les courbes qui représentent les densités de photons en fonction du pompage du milieu actif et d'analyser la stabilité linéaire des solutions obtenues.

  7. Etude theorique et experimentale des evaporateurs de dioxyde de carbone operant dans des conditions de givrage

    NASA Astrophysics Data System (ADS)

    Bendaoud, Adlane Larbi

    Les evaporateurs de refrigeration sont surtout du type tube a ailettes, appeles serpentins, et fonctionnent dans l'une des conditions suivantes: seche, humide ou avec formation de givre. Il a ete demontre que la formation du givre sur la paroi exterieure de l'echangeur engendre une surconsommation energetique a cause des operations de degivrage puisque 15 a 20% seulement de la chaleur produite sert au degivrage tandis que le reste est dissipee dans l'environnement [1]. Avec l'avenement des nouveaux refrigerants, moins nocifs envers l'environnement, l'industrie du froid se trouve penalisee du fait que peu ou pas de composantes mecaniques (compresseur, pompe, echangeur...etc.) adaptees sont disponibles [3]. Il s'agit pour la communaute des frigoristes de combler ce retard technologique en redeveloppant ces composantes mecaniques afin qu'elles soient adaptees aux nouveaux refrigerants. Dans cette optique, et afin de mieux comprendre le comportement thermique des evaporateurs au CO2 fonctionnant dans des conditions seches, qu'un groupe de chercheurs du CanmetENERGIE avaient lance, en 2000, un programme de R & D. Dans le cadre de programme un outil de simulation des evaporateurs au CO2 a ete developpe et un banc d'essai contenant une boucle secondaire de refrigeration utilisant le CO2 comme refrigerant a ete construit. Comme continuite de ce travail de recherche, en 2006 ce meme groupe de recherche a lance un nouveau projet qui consiste a faire une etude theorique et experimentale des evaporateurs au CO2 operants dans des conditions de givrage. Et, c'est exactement dans le cadre de ce projet que se positionne ce travail de these. Ce travail de recherche a ete entrepris pour mieux comprendre le comportement thermique et hydrodynamique des serpentins fonctionnant dans des conditions de givrage, l'effet des circuits de refrigerant ainsi que celui des parametres geometriques et d'operation. Pour cela, un travail theorique supporte par une etude experimentale a ete effectue

  8. Numerical Simulation of the MSL Dynamic Albedo of Neutrons (DAN) Instrument

    NASA Astrophysics Data System (ADS)

    Jun, I.; Mitrofanov, I.; Litvak, M.; Varenikov, A.

    2012-12-01

    The DAN instrument on the Mars Science Laboratory (MSL) has been tasked with detecting enhanced level of hydrogen content in the Martian subsurface. DAN accomplishes this goal by irradiating pulses of 14 MeV neutrons to the subsurface below the rover and by measuring the die-away time profiles of epi-thermal and thermal neutrons from the subsurface. Increased levels of thermal neutron are highly indicative of the presence of hydrogen (and thus water) in the soil. However, there are many factors that influence the thermalization process as well. To better understand the significance of these factors, we used the Monte Carlo N-Particle Extended (MCNPX) code to investigate numerous difference cases simulating conditions on the Martian surface that may affect the characteristics of die away curves. The results provide an insight into the varying impacts of factors such as water content in the soil, soil depth, soil density, temperature, soil elemental composition, and rover internal structure on the level of thermal neutrons, and ultimately better equip us to interpret real data from MSL. We will present some of the numerical simulation results performed on these factors, especially the effect of the mass distribution within the rover on the time profiles of thermal and epi-thermal neutron die-away curves. We also plan to show initial DAN measurement data obtained from a few months' of operation on the mars surface at the time of the conference.

  9. In-medium nuclear interactions of low-energy hadrons

    NASA Astrophysics Data System (ADS)

    Friedman, E.; Gal, A.

    2007-11-01

    Exotic atoms provide a unique laboratory for studying strong interactions and nuclear medium effects at zero kinetic energy. Experimental and theoretical developments of the last decade in the study of exotic atoms and some related low-energy reactions are reviewed. The exotic atoms considered are of π-,K-,pbar,Σ-, and also the so far unobserved Ξ- atoms. The analysis of these atomic systems consists of fitting density-dependent optical potentials Vopt=t(ρ)ρ to comprehensive sets of data of strong-interaction level shifts, widths and yields across the periodic table. These provide information on the in-medium hadron-nucleon t matrix t(ρ) over a wide range of densities up to central nuclear densities. For pions, the review focuses on the extraction of the πN in-medium s-wave interaction from pionic atoms, which include also the deeply bound π- atomic states recently observed at GSI in isotopes of Sn and Pb. Also included are recent measurements at PSI of elastic scattering of π± on Si, Ca, Ni and Zr at 21.5 MeV. The experimental results are analyzed in the context of chirally motivated π-nuclear potentials, and the evidence for partial restoration of chiral symmetry in dense nuclear matter is critically discussed. For antikaons, we review the evidence from K- atoms, and also from low-energy K-p scattering and reaction data for and against a deepKbar-nucleus potential of 150-200 MeV attraction at nuclear matter density. The case for relatively narrow deeply bound K-atomic states is made, essentially independent of the potential-depth issue. Recent experimental suggestions from KEK and DA ΦNE (Frascati) for signals of Kbar-nuclear deeply bound states are reviewed, and dynamical models for calculating binding energies and widths of Kbar- nuclear states are discussed. For kaons we review the evidence, from K+ total and reaction cross section measurements at the AGS (BNL) on Li, C, Si and Ca at plab=500-700 MeV/c, for significant absorptivity of tKN

  10. Effets Seebeck et Nernst dans les cuprates: Etude de la reconstruction de la surface de Fermi sous champ magnetique intense

    NASA Astrophysics Data System (ADS)

    Laliberte, Francis

    2010-06-01

    Ce memoire presente des mesures de transport thermoelectrique, les effets Seebeck et Nernst, dans une serie d'echantillons de supraconducteurs a haute temperature critique. Des resultats obtenus recemment au Laboratoire National des Champs Magnetiques Intenses a Grenoble sur La1.7Eu0.2Sr0.1 CuO4, La1.675Eu0.2Sr0.125CuO 4, La1.64Eu0.2Sr0.16CuO4, La1.74Eu0.1Sr0.16CuO4 et La 1.4Nd0.4Sr0.2CuO4 sont analyses. Une attention particuliere est accordee aux equations de la theorie semi-classique du transport et leur validite est verifiee. La procedure experimentale et les materiaux utilises pour concevoir les montages de mesures sont expliques en detail. Enfin, un chapitre est dedie a l'explication et l'interpretation des resultats de transport thermoelectrique sur YBa2Cu3O6+delta publies au cours de l'hiver 2010 dans les revues Nature et Physical Review Letters. Les donnees d'effet Seebeck dans les echantillons de La 1.8-x,Eu0.2SrxCuO 4, ou un changement de signe est observe, permettent de conclure a la presence d'une poche d'electrons dans la surface de Fermi qui domine le transport a basse temperature dans la region sous-dopee du diagramme de phase. Cette conclusion est similaire a celle obtenue par des mesures d'effet Hall dans YBa 2Cu3O6+delta et elle cadre bien dans un scenario de reconstruction de la surface de Fermi. Les donnees d'effet Nernst recueillies indiquent que la contribution des fluctuations supraconductrices est limitee a un modeste intervalle de temperature au-dessus de la temperature critique.

  11. Les bisphosphonates dans le traitement de l’ostéoporose

    PubMed Central

    Brown, Jacques P.; Morin, Suzanne; Leslie, William; Papaioannou, Alexandra; Cheung, Angela M.; Davison, Kenneth S.; Goltzman, David; Hanley, David Arthur; Hodsman, Anthony; Josse, Robert; Jovaisas, Algis; Juby, Angela; Kaiser, Stephanie; Karaplis, Andrew; Kendler, David; Khan, Aliya; Ngui, Daniel; Olszynski, Wojciech; Ste-Marie, Louis-Georges; Adachi, Jonathan

    2014-01-01

    Résumé Objectif Exposer l’efficacité et les risques du traitement par les bisphosphonates dans la prise en charge de l’ostéoporose et décrire les patients qui seraient de bons candidats aux congés thérapeutiques. Qualité des données Une recherche dans MEDLINE (PubMed, jusqu’au 31 décembre 2012) a permis de relever les publications pertinentes pour l’inclusion. La plupart des données probantes citées sont de niveau II (tirées d’essais non randomisés, de cohorte et d’autres essais comparatifs). Message principal L’efficacité des bisphosphonates de premier recours homologués pour la prévention des fractures a été éprouvée dans le cadre d’essais cliniques randomisés et contrôlés. Cependant, l’usage clinique répandu et prolongé des bisphosphonates a donné lieu à des rapports de manifestations indésirables rares, mais graves. L’ostéonécrose maxillaire et les fractures atypiques sous-trochantériennes ou diaphysaires du fémur seraient liées à l’emploi des bisphosphonates dans le traitement de l’ostéoporose, mais ces manifestations sont extrêmement rares et lorsqu’elles surviennent, elles sont accompagnées d’autres comorbidités ou de l’emploi concomitant de médicaments. Les congés thérapeutiques ne peuvent être envisagés que chez les patients à faible risque et dans un groupe restreint de patients dont le risque de fracture est modéré après un traitement de 3 à 5 ans. Conclusion Lorsque les bisphosphonates sont prescrits à des patients dont le risque de fracture est élevé, leur effet de prévention des fractures l’emporte de loin sur leurs torts potentiels. Chez les patients qui prennent des bisphosphonates depuis 3 à 5 ans, il faut réévaluer le besoin de poursuivre le traitement.

  12. Les superpolynomes symetriques dans les problemes a plusieurs corps de la mecanique quantique supersymetrique

    NASA Astrophysics Data System (ADS)

    Desrosiers, Patrick

    S'inspirant de la supersymetrie, on construit dans cette these une nouvelle generalisation de la theorie des fonctions symetriques. Une theorie physique est supersymetrique si: (1) elle contient des bosons (particules de spin entier) et des fermions (particules de spin demi-entier); (2) elle reste inchangee suite a une transformation des bosons en fermions et vice versa. Les fonctions symetriques dans le superespace (superfonctions symetriques) incorporent a la fois des variables commutatives (bosoniques) et anticommutatives (fermioniques). Ces dernieres engendrent une algebre de Grassmann. Une superfonction symetrique est invariante sous l'echange simultane des variables bosoniques et fermioniques (action diagonale du groupe symetrique); elle se caracterise par une superpartition, i.e., une juxtaposition appropriee de partitions usuelles d'entiers non negatifs. On utilise deux approches dans l'elaboration de la theorie des superfonctions symetriques: l'une provient de la combinatoire et l'autre, de la physique. Suivant la premiere approche, on obtient l'extension des elements standards de la theorie des fonctions symetriques fonctions monomiales, fonctions symetriques elementaires, fonctions completement symetriques, series de puissances, fonctions generatrices et formules de Cauchy. On demontre egalement qu'il existe une extension naturelle, a un parametre, du produit scalaire combinatoire defini par l'orthogonalite des series de puissances dans le superespace. La seconde approche consiste a resoudre des problemes a N corps de la mecanique quantique supersymetrique. On etudie les extensions supersymetriques des modeles Calogero-Moser-Sutherland (CMS), lesquels decrivent l'evolution de particules dont le potentiel d'inter action est proportionnel a l'inverse du carre de la distance separant les particules. Deux modeles supersymetriques CMS sont resolus: trigonometrique (sur un cercle) et rationnel (sur une ligne) avec confinement harmonique. Leurs fonctions d

  13. Les reconstructions acétabulaires dans les prothèses totales de hanche

    PubMed Central

    Zejjari, Hassane; Louaste, Jamal; Cherrad, Taoufik; Bousbae, Hicham; Kasmaoui, Housseine; Amhajji, Larbi; Rachid, Khalid

    2015-01-01

    La chirurgie de reconstruction acétabulaire est une technique qui consiste à combler les pertes de substance osseuse siégeant au niveau du cotyle. Il s'agit d'une étude rétrospective de 15 patients (16 cotyles), sur une période de 6 ans (2006- 2012). Dans douze cas il s'agissait de prothèse totales de la hanche de première intention et dans quatre cas il s'agissait de reprise cotyloïdienne de PTH. L’évaluation clinique préopératoire et postopératoire de tous nos patients a été effectuée par le score de Postel et Merle d'Aubigné. L’évaluation des pertes de substances osseuse du cotyle a été classée selon la classification de Paprosky. L’âge moyen de nos patients au moment de l'intervention a été de 57 ans avec des extrêmes allant de 20 ans à 76 ans. La greffe osseuse a été utilisée chez 12 de nos patients. La reconstruction prothétique a été utilisée chez 8 patients (anneau de Kerboul dans six cas et anneau de Burch-Schneider dans deux cas). Recul post opératoire moyen a été de 56 mois. L’évaluation radiologique a été basée sur les clichés radiologiques du bassin de face strict ainsi que des radiographies de la hanche opérée de face prenant la totalité de la prothèse. Nos résultats cliniques et radiologiques ont été jugé bon à très bon dans la majorité des cas. Pour nous, nous optant pour le recentrage-reconstruction car c'est lui qui s'approche le plus de l'anatomie et de la biomécanique normale de la hanche. PMID:26955415

  14. Sensibilité aux antibiotiques des souches destaphylococcus aureus communautaires dans la région de Nouakchott (Mauritanie)

    PubMed Central

    Salem, Mohamed Lemine Ould; Ghaber, Sidi Mohamed; Baba, Sidi El Wafi Ould; Maouloud, Mohamed Mahmoud Ould

    2016-01-01

    Introduction Staphylocoque aureus reste un pathogène majeur de l'homme causant des infections très diverses, cutanées, urinaires, pulmonaires ainsi que des septicémies. L'objectif de ce travail est d'évaluer la sensibilité des souches communautaires de Staphylococcus aureus isolées dans différents produits pathologiques vis-à-vis des principaux antibiotiques utilisés, dans la région de Nouakchott (Mauritanie). Méthodes Il s'agit d'une étude rétrospective réalisée sur 281 souches de Staphylococus aureus isolées entre Janvier 2014 et Août 2015 au laboratoire du Centre Hospitalier National et aux deux laboratoires privés de la ville de Nouakchott, dans différents produits pathologiques des patients non hospitalisés. La sensibilité aux antibiotiques a été déterminée par la méthode de diffusion de disques en milieu gélosé de Mueller Hinton selon les recommandations du CA-SFM. Résultats Le taux de résistance à la pénicilline G était élevé (96 à 100%). Le taux de SARM communautaires se situe entre 25 et 26% dans les suppurations, de 34,3% dans les ECBU et de 28% dans les spermocultures. La résistance aux Macrolides-Lincosamyne-Streptogramines (MLS), donnant le phénotype MLSb inductible, était retrouvée dans 6% des souches urinaires et 27% des souches isolées à partir des suppurations. L'activité des aminosides est variable, l'amikacine était active sur toutes les souches. L'activité du cotrimoxazol est faible (77% de résistance) et aucune résistance à la vancomycine n'a été notée. Conclusion L'activité de la Pénicilline G sur les souches de Staphylococcus aureus isolées dans la région de Nouakchott est quasi nulle et le taux de SARM communautaire est important atteignant jusqu'à 34%. Ceci pourrait être expliqué par l'usage anarchique de ces molécules dans notre pays. PMID:28154631

  15. PIC: Protein Interactions Calculator

    PubMed Central

    Tina, K. G.; Bhadra, R.; Srinivasan, N.

    2007-01-01

    Interactions within a protein structure and interactions between proteins in an assembly are essential considerations in understanding molecular basis of stability and functions of proteins and their complexes. There are several weak and strong interactions that render stability to a protein structure or an assembly. Protein Interactions Calculator (PIC) is a server which, given the coordinate set of 3D structure of a protein or an assembly, computes various interactions such as disulphide bonds, interactions between hydrophobic residues, ionic interactions, hydrogen bonds, aromatic–aromatic interactions, aromatic–sulphur interactions and cation–π interactions within a protein or between proteins in a complex. Interactions are calculated on the basis of standard, published criteria. The identified interactions between residues can be visualized using a RasMol and Jmol interface. The advantage with PIC server is the easy availability of inter-residue interaction calculations in a single site. It also determines the accessible surface area and residue-depth, which is the distance of a residue from the surface of the protein. User can also recognize specific kind of interactions, such as apolar–apolar residue interactions or ionic interactions, that are formed between buried or exposed residues or near the surface or deep inside. PMID:17584791

  16. PIC: Protein Interactions Calculator.

    PubMed

    Tina, K G; Bhadra, R; Srinivasan, N

    2007-07-01

    Interactions within a protein structure and interactions between proteins in an assembly are essential considerations in understanding molecular basis of stability and functions of proteins and their complexes. There are several weak and strong interactions that render stability to a protein structure or an assembly. Protein Interactions Calculator (PIC) is a server which, given the coordinate set of 3D structure of a protein or an assembly, computes various interactions such as disulphide bonds, interactions between hydrophobic residues, ionic interactions, hydrogen bonds, aromatic-aromatic interactions, aromatic-sulphur interactions and cation-pi interactions within a protein or between proteins in a complex. Interactions are calculated on the basis of standard, published criteria. The identified interactions between residues can be visualized using a RasMol and Jmol interface. The advantage with PIC server is the easy availability of inter-residue interaction calculations in a single site. It also determines the accessible surface area and residue-depth, which is the distance of a residue from the surface of the protein. User can also recognize specific kind of interactions, such as apolar-apolar residue interactions or ionic interactions, that are formed between buried or exposed residues or near the surface or deep inside.

  17. Design of interpenetrated network MWCNT/poly(1,5-DAN) on interdigital electrode: toward NO2 gas sensing.

    PubMed

    Nguyen, Dzung Tuan; Nguyen, My Thanh; Ho, Giang Truong; Nguyen, Toan Ngoc; Reisberg, S; Piro, B; Pham, M C

    2013-10-15

    In this paper, poly(1,5-diaminonaphthalene) was interpenetrated into the network made of multiwalled carbon nanotubes (MWCNT) on platinum interdigital electrode (IDE) by electro-polymerization of 1,5-diaminonaphthalene (1,5-DAN). The electro-polymerization process of 1,5-DAN on MWCNT was controlled by scanning the cyclic voltage at 50 mV s(-1) scan rate between -0.1 V and +0.95 V vs. saturated calomel electrode (SCE). The results of voltammetric responses and Raman spectroscopy represented that the films MWCNT/poly(1,5-DAN) were successfully created by this polymerization process. The films MWCNT/poly(1,5-DAN) were investigated for gas-sensing to NO2 at low concentration level. The gas-sensing results showed that the response-recovery times were long and strongly affected by thickness of the film MWCNT/poly(1,5-DAN). Nevertheless, these films represented auspicious results for gas sensors operating at room temperature.

  18. DanQ: a hybrid convolutional and recurrent deep neural network for quantifying the function of DNA sequences.

    PubMed

    Quang, Daniel; Xie, Xiaohui

    2016-06-20

    Modeling the properties and functions of DNA sequences is an important, but challenging task in the broad field of genomics. This task is particularly difficult for non-coding DNA, the vast majority of which is still poorly understood in terms of function. A powerful predictive model for the function of non-coding DNA can have enormous benefit for both basic science and translational research because over 98% of the human genome is non-coding and 93% of disease-associated variants lie in these regions. To address this need, we propose DanQ, a novel hybrid convolutional and bi-directional long short-term memory recurrent neural network framework for predicting non-coding function de novo from sequence. In the DanQ model, the convolution layer captures regulatory motifs, while the recurrent layer captures long-term dependencies between the motifs in order to learn a regulatory 'grammar' to improve predictions. DanQ improves considerably upon other models across several metrics. For some regulatory markers, DanQ can achieve over a 50% relative improvement in the area under the precision-recall curve metric compared to related models. We have made the source code available at the github repository http://github.com/uci-cbcl/DanQ.

  19. Ground-atmosphere interactions at Gale

    NASA Astrophysics Data System (ADS)

    Renno, N. O.; Martinez, G.; Ramos, M.; Hallet, B.; Gómez, F. G.; Jun, I.; Fisk, M. R.; Gomez-Elvira, J.; Hamilton, V. E.; Mischna, M. A.; Sletten, R. S.; Martin-Torres, J.; De La Torre Juarez, M.; Vasavada, A. R.; Zorzano, M.

    2013-12-01

    We analyze variations in environmental parameters and regolith properties along Curiosity's track to determine the possible causes of an abrupt change in the thermal properties of the ground and the atmosphere observed around Sol 120, as the rover transitioned from an area of sandy soil (Rocknest) to an area of fractured bedrock terrain (Yellowknife). Curiosity is instrumented with the Rover Environmental Monitoring Station (REMS) and the Dynamic Albedo of Neutrons (DAN) sensors to measure the air temperature, the ground temperature, and the hydrogen content of the shallow subsurface along Curiosity's track. Analysis of the REMS data is used to estimate the regolith's heat budget. This analysis suggests that the abrupt decrease in the ground and atmosphere temperature and the difference between ground and air temperatures observed around Sol 120 is likely caused by an increase in the soil thermal inertia. The changes in thermal inertia have been known for some time so confirming this by the REMS package provides ground truthing. A new unexpected finding is that the regolith water content, as indicated by DAN's detection of hydrogen content, is higher in the Yellowknife soil. Another interesting finding at this site are the holes and other signs of recent geological activity in the area of fractured terrain that may reflect large volumetric variations and facilitate gas exchange between the ground and atmosphere. Near-surface volumetric changes in soil and bedrock could reflect changes in the volume of subsurface H2O, or in the partitioning of H2O among its three phases. Volume increases could also result from salt crystal growth in rock pores and soil pores associated with the adsorption of water vapor. Crystallization in pores is a significant weathering process on Earth; it could well be active on Mars. Salts also inhibits the exchange of moisture between the ground and the atmosphere, and cements the soils of arid places such as in the McMurdo Dry Valleys in

  20. On the modeling of snake venom serine proteinase interactions with benzamidine-based thrombin inhibitors

    PubMed Central

    Henriques, Elsa S.; Fonseca, Nelson; Ramos, Maria João

    2004-01-01

    Pit viper venoms contain a number of serine proteinases that exhibit one or more thrombin-like activities on fibrinogen and platelets, this being the case for the kinin-releasing and fibrinogen-clotting KN-BJ from the venom of Bothrops jararaca. A three-dimensional structural model of the KN-BJ2 serine proteinase was built by homology modeling using the snake venom plasminogen activator TSV-PA as a major template and porcine kallikrein as additional structural support. A set of intrinsic buried waters was included in the model and its behavior under dynamic conditions was molecular dynamics simulated, revealing a most interesting similarity pattern to kallikrein. The benzamidine-based thrombin inhibitors α-NAPAP, 3-TAPAP, and 4-TAPAP were docked into the refined model, allowing for a more insightful functional characterization of the enzyme and a better understanding of the reported comparatively low affinity of KN-BJ2 toward those inhibitors. PMID:15322279

  1. Modelisation de l'erosion et des sources de pollution dans le bassin versant Iroquois/Blanchette dans un contexte de changements climatiques

    NASA Astrophysics Data System (ADS)

    Coulibaly, Issa

    Principale source d'approvisionnement en eau potable de la municipalite d'Edmundston, le bassin versant Iroquois/Blanchette est un enjeu capital pour cette derniere, d'ou les efforts constants deployes pour assurer la preservation de la qualite de son eau. A cet effet, plusieurs etudes y ont ete menees. Les plus recentes ont identifie des menaces de pollution de diverses origines dont celles associees aux changements climatiques (e.g. Maaref 2012). Au regard des impacts des modifications climatiques annonces a l'echelle du Nouveau-Brunswick, le bassin versant Iroquois/Blanchette pourrait etre fortement affecte, et cela de diverses facons. Plusieurs scenarios d'impacts sont envisageables, notamment les risques d'inondation, d'erosion et de pollution a travers une augmentation des precipitations et du ruissellement. Face a toutes ces menaces eventuelles, l'objectif de cette etude est d'evaluer les impacts potentiels des changements climatiques sur les risques d'erosion et de pollution a l'echelle du bassin versant Iroquois/Blanchette. Pour ce faire, la version canadienne de l'equation universelle revisee des pertes en sol RUSLE-CAN et le modele hydrologique SWAT ( Soil and Water Assessment Tool) ont ete utilises pour modeliser les risques d'erosion et de pollution au niveau dans la zone d'etude. Les donnees utilisees pour realiser ce travail proviennent de sources diverses et variees (teledetections, pedologiques, topographiques, meteorologiques, etc.). Les simulations ont ete realisees en deux etapes distinctes, d'abord dans les conditions actuelles ou l'annee 2013 a ete choisie comme annee de reference, ensuite en 2025 et 2050. Les resultats obtenus montrent une tendance a la hausse de la production de sediments dans les prochaines annees. La production maximale annuelle augmente de 8,34 % et 8,08 % respectivement en 2025 et 2050 selon notre scenario le plus optimiste, et de 29,99 % en 2025 et 29,72 % en 2050 selon le scenario le plus pessimiste par rapport a celle

  2. Grossesse dans une corne rudimentaire: difficultés diagnostiques et prise en charge thérapeutique

    PubMed Central

    Mamouni, Nisrine; Ghazal, Nabil; Erraghay, Sanaa; Bouchikhi, Chahrazed; Banani, Abdelaziz

    2016-01-01

    La survenue d'une grossesse dans une corne utérine rudimentaire est une situation obstétricale extrêmement rare et potentiellement grave, menaçant le pronostic materno-fœtal. Les auteurs rapportent cinq observations de grossesse dans une corne utérine rudimentaire, à travers lesquelles, ils relatent les difficultés sur le plan diagnostique ainsi que la prise en charge thérapeutique de cette entité pathologique, soulignant l'intérêt de l’échographie endovaginale, de l'IRM pelvienne et de la cœlioscopie dans le diagnostic précoce de ce type de malformation uterine. PMID:27583078

  3. Food and Drug Interactions.

    PubMed

    Choi, Jong Hwan; Ko, Chang Mann

    2017-01-01

    Natural foods and vegetal supplements have recently become increasingly popular for their roles in medicine and as staple foods. This has, however, led to the increased risk of interaction between prescribed drugs and the bioactive ingredients contained in these foods. These interactions range from pharmacokinetic interactions (absorption, distribution, metabolism, and excretion influencing blood levels of drugs) to pharmacodynamic interactions (drug effects). In a quantitative respect, these interactions occur mainly during metabolism. In addition to the systemic metabolism that occurs mainly in the liver, recent studies have focused on the metabolism in the gastrointestinal tract endothelium before absorption. Inhibition of metabolism causes an increase in the blood levels of drugs and could have adverse reactions. The food-drug interactions causing increased blood levels of drugs may have beneficial or detrimental therapeutic effects depending on the intensity and predictability of these interactions. It is therefore important to understand the potential interactions between foods and drugs should and the specific outcomes of such interactions.

  4. Processus mis en jeu dans l'evolution morpho-dynamique de Roberts Bank (Delta du Fraser): Observation et modelisation hydrodynamiques et sedimentaires

    NASA Astrophysics Data System (ADS)

    Meule, Samuel

    Roberts Bank couvre le delta intertidal entre le bras principal du fleuve Fraser et la pointe du Cap Roberts en Colombie Britannique, Canada. Sous la pression du developpement urbain et la modification du regime sedimentaire, cette plage de sable fin est soumise a une erosion significative. L'identification des forces hydrodynamiques, leur importance et leur interaction permettent de determiner les zones de transport, et donc la stabilite de Roberts Bank. Deux periodes de mesures associees a des phases de modelisation de la houle et des courants ont ete effectuees lors de ce travail. La premiere periode de mesure, entre le 29 juin et le 8 juillet 2001, a permis l'identification de processus hydrodynamiques et sedimentaires associes aux forts courants de maree presents le long de Roberts Bank. La seconde phase de mesure, entre le 1er mars et le 26 mars 2002, a permis d'etudier les processus de remise en suspension associes a la houle. Des phases de modelisation ont ete menees a partir des connaissances acquises sur le terrain, afin d'affiner la comprehension des processus sedimentaires et notamment les interactions houle - courant - sediment. Les mecanismes, mis en evidence dans cette etude, participent au faconnage de Roberts Bank, contribuent a son erosion et a la mise en place de nouvelles structures sedimentaires. Les courants de flot de maree vont initier la creation de nuages de resuspension de sediment depuis le fond. En eau peu profonde, la composante " onshore" du courant de maree induit un transport a la cote, tandis qu'en eau plus profonde une faible composante " offshore" du courant peut favoriser un transport au large le long de la pente. Les chenaux, les dunes subaquatiques et les surfaces d'erosion affleurantes fournissent une rugosite de fond suffisante a la generation de turbulence et donc de nuages de sediment en suspension. Lors de la maree de jusant, les sediments resuspendus en eau peu profonde, sont transportes vers le large a partir d

  5. Investigation de l'anisotropie du gap supraconducteur dans les composes Ba(Fe(1-x)Co(x))2As2, Ba(1-x)K(x)Fe2As2, LiFeAs et Fe1-deltaTe(1-x)Se(x)

    NASA Astrophysics Data System (ADS)

    Reid, Jean-Philippe

    ommaire La structure du gap supraconducteur et sa modulation sont intimement liees au potentiel d'interaction responsable de l'appariement des electrons d'un supraconducteur. Ainsi, l'etude de la structure du gap-SC et de sa modulation permettent de faire la lumiere sur la nature du mecanisme d'appariement des electrons. A cet egard, les resultats experimentaux des supraconducteurs a base de fer ne cadrent pas dans un seul ensemble, ce qui est en opposition au gap-SC universel des cuprates. Dans ce qui suit, nous presenterons une etude systematique du gap-SC pour plusieurs pnictides. En effet, en utilisant la conductivite thermique, une sonde directionnelle du gap-SC, nous avons ete en mesure de reveler la structure du gap-SC pour les composes suivants : Ba1-xKxFe 2As2, Ba(Fe1-xCo x)2As2, LiFeAs et Fe1-deltaTe 1-xSex. L'etude de ces quatre composes, de trois differentes familles structurales, a pu etablir un tableau partiel mais tres exhaustif de la structure du gap-SC de pnictides. En effet, tel qu'illustre dans cette these, ces quatre composes ne possedent aucun noeud dans leur structure du gap-SC a dopage optimal. Toutefois, a une concentration differente de celle optimale pour les composes K-Ba122 et Co-Ba122, des noeuds apparaissent sur la surface de Fermi, aux extremites 'du dome supraconducteur. Ceci suggere fortement que, pour ces composes, la presence de noeuds sur la surface de Fermi est nuisible a la phase supraconductrice. Mots-cles: Supraconducteurs a base de fer, Pnictides, Structure du gap supraconducteur, Conductivite thermique

  6. Interpretation des donnees de flux de chaleur et de gravite dans le bouclier Canadien

    NASA Astrophysics Data System (ADS)

    Cheng, Li Zhen

    2000-10-01

    Le champ geothermique du Bouclier Canadien est caracterise par un flux moyen de 41 mW·m-2, qui suggere une production de chaleur moyenne dans la croute comprise entre 0.7 et 0.8 muW·m-3. Le flux de chaleur relativement faible favorise la stabilite du bouclier et lui a permis de resister a la deformation tectonique. Les variations du flux de chaleur a la surface sont dominees par la composition de la croute. Un flux eleve implique generalement une composition felsique et il est d'autant plus faible que la croute devient plus mafique. La production de chaleur en surface n'est pas representative de la production moyenne de la croute. Le flux de chaleur dans le Boucher Canadien ne depend donc pas de la production de chaleur en surface, mais depend de la composition principale de la croute. L'interpretation combinee des donnees geophysiques nous permet de determiner les variations de composition d'echelle crustale a partir desquelles il est possible d'etablir la structure de la croute. L'etude detaillee de l'Orogene de Trans-Hudson et de la Sous-province d'Abitibi a montre que le flux de chaleur, la gravite et la sismique lorsqu'elles sont combinees fournissent des contraintes efficaces pour determiner l'architecture crustale. En general, la croute est trop resistante pour se deformer par fluage, excepte tres localement. Le mode de deformation de la lithosphere continentale depend de la composition et du gradient geothermique. Nous montrons que la lithosphere du Bouclier Canadien demeure principalement fragile jusqu'a une profondeur de plus de 150 km. Une deformation ductile pourrait cependant etre possible localement a la base de la, croute, comme dans la ceinture de Thompson par exemple. Si l'on admet que la lithosphere peut resister a des contraintes allant jusqu'a 20 MPa (taux de deformation 3˙ < 10-15 s-1), l'epaisseur de la lithosphere est de l'ordre de 300 km pour la ceinture de Thompson et est superieure a 300 km pour la sous-province d'Abitibi. La resistance

  7. Absorptions UV dans le fonctionnement des sources lasers solides à ions de terres rares

    NASA Astrophysics Data System (ADS)

    Moncorgé, R.; Margerie, J.; Doualan, J. L.; Nagtegaele, P.; Guyot, Y.

    2006-12-01

    L'article donne une description et analyse les phénomènes d'absorption UV à l'origine des mécanismes de solarisation et de variation d'indice de réfraction observés dans certains matériaux dopés terres rares étudiés pour leurs propriétés laser UV ou infrarouge lorsqu'ils sont soumis à de fortes densités d'excitation optique.

  8. Interacting dark sector with transversal interaction

    SciTech Connect

    Chimento, Luis P.; Richarte, Martín G.

    2015-03-26

    We investigate the interacting dark sector composed of dark matter, dark energy, and dark radiation for a spatially flat Friedmann-Robertson-Walker (FRW) background by introducing a three-dimensional internal space spanned by the interaction vector Q and solve the source equation for a linear transversal interaction. Then, we explore a realistic model with dark matter coupled to a scalar field plus a decoupled radiation term, analyze the amount of dark energy in the radiation era and find that our model is consistent with the recent measurements of cosmic microwave background anisotropy coming from Planck along with the future constraints achievable by CMBPol experiment.

  9. Gestalt Interactional Groups

    ERIC Educational Resources Information Center

    Harman, Robert L.; Franklin, Richard W.

    1975-01-01

    Gestalt therapy in groups is not limited to individual work in the presence of an audience. Describes several ways to involve gestalt groups interactionally. Interactions described focus on learning by doing and discovering, and are noninterpretive. (Author/EJT)

  10. Computerized Interactive Harness Engineering

    NASA Technical Reports Server (NTRS)

    Billitti, J. W.

    1985-01-01

    Computerized interactive harness engineering program inexpensive, interactive system for learning and using engineering approach to interconnection systems. Basically data-base system that stores information as files of individual connectors and handles wiring information in circuit groups stored as records.

  11. Interactions between magnetohydrodynamical discontinuities

    SciTech Connect

    Dai, W.; Woodward, P.R. )

    1994-11-01

    Interactions between magnetohydrodynamical (MHD) discontinuities are studied through numerical simulations for the set of one-dimensional MHD equations. The interactions include the impact of a shock on a contact discontinuity, the collision of two shocks, and the catchup of a shock over another shock. The shocks involved in the interactions may be very strong. Each shock in an interaction may be either a fast or a slow shock.

  12. Interactivity: A Forgotten Art?

    ERIC Educational Resources Information Center

    Sims, Rod

    1997-01-01

    This paper promotes further discussion and analysis of interactivity in learning environments and contains a classification of interaction types appropriate for consideration in multimedia settings. Through an examination of related factors associated with navigation and control, a matrix of interactive dimensions is proposed. (Author)

  13. Global Interaction in Design

    ERIC Educational Resources Information Center

    Bennett, Audrey Grace

    2010-01-01

    Based on a virtual conference, Glide'08 (Global Interaction in Design Education), that brought international design scholars together online, this special issue expands on the topics of cross-cultural communication and design and the technological affordances that support such interaction. The author discusses the need for global interaction in…

  14. Dynamic Interactive Learning Systems

    ERIC Educational Resources Information Center

    Sabry, Khaled; Barker, Jeff

    2009-01-01

    This paper reviews and discusses the notions of interactivity and dynamicity of learning systems in relation to information technologies and design principles that can contribute to interactive and dynamic learning. It explores the concept of dynamic interactive learning systems based on the emerging generation of information as part of a…

  15. Une formation à la recherche en médecine transfusionnelle dans le monde francophone

    PubMed Central

    Shiboski, C.; Fontanet, A.; Murphy, E.L.

    2010-01-01

    Un enseignement accéléré et francophone de formation à la recherche en médecine transfusionnelle a été récemment instauré à l’Institut Pasteur de Paris, sous la codirection de membres hospitalo-universitaires de l’université de Californie San Francisco (UCSF), du Blood Systems Research Institute (BSRI) et de l’Institut national de la transfusion sanguine (INTS). Le but est de former des professionnels de la transfusion des pays en voie de développement à mener une activité de recherche dont les résultats peuvent contribuer à un renforcement de la qualité des soins transfusionnels et de la sécurité transfusionnelle dans leur pays. Le cours enseigne les méthodes de recherche clinique et épidémiologique, et leurs applications transfusionnelles potentielles. Chaque étudiant élabore au cours du stage un protocole personnel de recherche, qu’il lui sera loisible de mettre ensuite en pratique dans le centre de transfusion ou l’hôpital où il exerce. PMID:19640755

  16. Curiethérapie dans le traitement palliatif du cancer de l’œsophage

    PubMed Central

    Toulba, Ahmedou; Bakkali, Hanae; Boutayeb, Salwa; Kebdani, Tayeb; Ahid, Samir; Benjaafar, Noureddine

    2015-01-01

    Les patients atteints du cancer de l’œsophage ont souvent une maladie localement avancée, la dysphagie est le symptôme majeur chez la plupart de ces patients, plusieurs modalités thérapeutiques ont été utilisées pour améliorer cette dysphagie. Le but de ce travail est d’étudier l'efficacité et la tolérance de la curiethérapie haut débit de dose (HDR) endo-luminale dans le traitement palliatif des cancers de l’œsophage inopérable. Sur une période de 15 ans, l’étude a inclus les patients atteints de cancer de l’œsophage inopérable et/ou métastatique avec une dysphagie, sans extension à l'hypopharynx ou a la trachée et qui ont bénéficié d'une curiethérapie HDR avec ou sans radiothérapie externe à visée palliative. Au total 46 patients ont été inclus dans l’étude, 58,7% étaient des hommes, 42,2% avaient une dysphagie grade 2 et 37,8% étaient aphagiques, 78,6% des patients étaient performance satus PS 2, l'amaigrissement à été trouvé chez 81,4%, la localisation de la tumeur était surtout au niveau du tiers moyen et inférieur dans 97,8%, la hauteur médiane de la tumeur était de 7 cm (5,5-9), le carcinome épidermoïde était le type histologique le plus fréquent chez 31 patients (70,5%). Après un médiane de suivi de 5 mois, l'amélioration de la dysphagie a été retrouvée chez 76% des malades (p1]. L′incidence la plus élevée est observée dans certains pays notamment en Asie et en Afrique, et l′incidence dans les pays développés occidentaux est en augmentation [2]. Selon le registre du cancer de Rabat 2006-2008, le cancer de l’œsophage est rare et constitue 1,5% de tous les cancers chez l'homme [3]. Le taux de survie globale à 5 ans est de 8%, avec 80% des décès liés à l’évolution locale de la maladie [4]. Pour la minorité des patients avec une maladie localisée, le traitement par radiochimiothérapie concomitante avec ou sans chirurgie permet une amélioration de la survie [5]. Plus de 50

  17. Percolation dans des reseaux realistes de nanostructures de carbone

    NASA Astrophysics Data System (ADS)

    Simoneau, Louis-Philippe

    Carbon nanotubes have very interesting mechanical and electrical properties for various applications in electronics. They are highly resistant to deformation and can be excellent conductors or semiconductors. However, manipulating individual nanotubes to build structured devices remains very difficult. There is no method for controlling all of the electrical properties, the orientation and the spatial positioning of a large number of nanotubes. The fabrication of disordered networks of nanotubes is much easier, and these systems have a good electrical conductivity which makes them very interesting, especially as materials of transparent and flexible electrodes. There are three main methods of production used to make networks of nanotubes: the solution deposition, the direct growth on substrate and the embedding in a polymer matrix. The solution deposition method can form networks of various densities on a variety of substrates, the direct growth of nanotubes allows the creation of very clean networks on substrates such as SiO2, and the embedding in a polymer matrix can give composite volumes containing varying amounts of nanotubes. Many parameters such as the length of the tubes, their orientation or their tortuosity influence the properties of these networks and the presence of structural disorder complicates the understanding of their interactions. Predicting the properties of a network, such as conductivity, from a few characteristics such as size and density of the tubes can be difficult. This task becomes even more complex if one wants to identify the parameters that will optimize the performance of a device containing the material. We chose to address the carbon nanotube networks problem by developing a series of computer simulation tools that are mainly based on the Monte Carlo method. We take into account a large number of parameters to describe the characteristics of the networks, which allows for a more reliable representation of real networks as well as

  18. Les Elements Legers: Diffusion dans les Enveloppes Stellaires et Implications Cosmologiques

    NASA Astrophysics Data System (ADS)

    Richer, Jacques

    1992-01-01

    Les observations des abondances des elements legers (Z <= 5) sont utilisees pour estimer la quantitie de lithium qui a ete produite lors du Big -Bang, et obtenir simultanement des contraintes sur la nature des inhomogeneites qui ont pu exister durant la nucleosynthese primordiale. Nous utilisons un modele simple capable de simuler approximativement la diffusion et la retro-diffusion des neutrons a travers la matiere inhomogene durant les premieres minutes de l'expansion de l'Univers. Nous tenons compte de la difference possible entre l'abondance primordiale de Li et les abondances observees dans les plus vieilles etoiles. Cette difference (un facteur 2, environ) est estimee en construisant des modeles evolutifs d'etoiles peu massives de Population II, incluant la sedimentation gravitationnelle du lithium et de l'helium. Ces modeles montrent egalement que les ages des vieux amas stellaires sont grandement surestimes lorsqu'ils sont determines a partir de modeles stellaires n'incluant pas l'effet de la diffusion de He. Nous calculons ensuite comment evoluent les abondances de Li et Be dans des etoiles plus massives et plus jeunes, de la pre-sequence principale ou de la ZAMS, jusqu'a l'epuisement de leur hydrogene central. Les modeles incluent la sedimentation simultanee de l'helium a travers l'enveloppe. Une approche hierarchique (evolution du coeur--evolution de l'enveloppe --tri des elements traces) est utilisee pour simuler efficacement le grand nombre d'etoiles necessaire pour la construction d'isochrones. Une attention particuliere est portee aux consequences de la sedimentation de He sur l'etendue des zones convectives, et sur la diffusion de Li et Be. Les forces radiatives agissant sur ces deux elements sont calculees en detail a partir des donnees atomiques. Les etoiles simulees correspondent approximativement aux types spectraux A, F, et AmFm. Les abondances de Li et Be observees dans les etoiles jeunes de ces types sont comparees a nos predictions dans le

  19. Prediction inverse d'un front de solidification dans un four de transformation a haute temperature

    NASA Astrophysics Data System (ADS)

    Marois, Marc-Andre

    Ce projet de recherche porte sur une methode numerique permettant de predire l'evolution du profil 2D de la couche solide qui recouvre l'interieur des parois de plusieurs fours de transformation a haute temperature. Un modele mathematique base sur la formulation faible de l'energie est d'abord developpe et valide. Une methode de transfert thermique inverse reposant sur ce modele est ensuite developpee afin d'obtenir une mesure rapide et continue de l'evolution du profil de cette couche solide. Vu la grande inertie thermique du systeme a l'etude, differentes strategies sont proposees afin de faciliter la mise en uvre de cette methode numerique. Finalement, cette approche inverse est confrontee aux resultats experimentaux obtenus a l'aide d'un reacteur metallurgique. Une etude preliminaire montre que les fours de transformation presentent une tres grande inertie thermique qui limite grandement l'utilisation des methodes inverses. En effet, la sensibilite de cette methode numerique repose essentiellement sur le delai temporel observe entre la variation du profil du banc et la fluctuation de la temperature a la surface externe de la paroi du four. Les resultats obtenus demontrent qu'une partie de ce delai est proportionnel a la chaleur latente de fusion lorsque le materiau a changement de phase est constitue d'un melange non eutectique. Afin de limiter l'impact de ce delai temporel, deux astuces numeriques sont proposees : reutiliser plus d'une fois les mesures de temperature et modifier le probleme thermique dans les regions pateuse et liquide. D'une part, le concept de chevauchement propose permet de reduire le temps d'acquisition des donnees entre chacune des predictions. D'autre part, l'approche virtuelle developpee permet de reduire l'inertie thermique du systeme et, par le fait meme, le delai temporel associe a la diffusion de la chaleur. Ces deux strategies ont permis de predire efficacement l'evolution 1D de l'epaisseur de la couche de gelee qui se solidifie a

  20. Etude de la migration des interstitiels dans des austenites Fe, Cr (18), Ni (14) pures et industrielles par irradiation dans un microscope a tres haute tension: Role du carbone et du titane

    NASA Astrophysics Data System (ADS)

    Housseau, N.; Pelissier, J.

    1983-12-01

    Nous avons étudié le rôle des impurtés (C ou Ti) dans la condensation et la migration des défauts interstitiels. Les échantillons étudiés sont des aciers austénitiques: (a) acier de synthèse de haute pureté (Cr 18, Ni 14, Fe) avec ou sans carbone; (b) acier industriel avec C (800 ppm) ou Ti (0,45%). Les échantillons ont été irradiés dans un microscope à très haute tension aux doses allant de 10 -4 jusqu'à 10 -1 dpa aux températures de 300°C à 400°C. Dans de telles conditions les défauts observés sont des boucles interstitielles. L'étude de la variation de l'épaisseur de la zone dénudée près du bord de la lame mince en fonction de la température nous a permis d'évaluer l'énergie de migration effective de l'interstitiel dans ces alliages. Dans l'austénite de synthèse carburée ou non sa valeur est de 0.8 eV. Dans l'acier industriel au titane carburé ou non on obtient 2.0 eV. Nous n'avons pas observé d'effet lié au carbone. L'examen de la densité de boucles à saturation dans les divers aciers suggère une forte énergie de liaison interstitiel-titane. Cette énergie de liaison, si l'ont admet que le titane est la seule impureté agissante du système, peut être estimée à 1.2 eV.

  1. Evolving synergetic interactions

    PubMed Central

    Wu, Bin; Arranz, Jordi; Du, Jinming; Zhou, Da; Traulsen, Arne

    2016-01-01

    Cooperators forgo their own interests to benefit others. This reduces their fitness and thus cooperators are not likely to spread based on natural selection. Nonetheless, cooperation is widespread on every level of biological organization ranging from bacterial communities to human society. Mathematical models can help to explain under which circumstances cooperation evolves. Evolutionary game theory is a powerful mathematical tool to depict the interactions between cooperators and defectors. Classical models typically involve either pairwise interactions between individuals or a linear superposition of these interactions. For interactions within groups, however, synergetic effects may arise: their outcome is not just the sum of its parts. This is because the payoffs via a single group interaction can be different from the sum of any collection of two-player interactions. Assuming that all interactions start from pairs, how can such synergetic multiplayer games emerge from simpler pairwise interactions? Here, we present a mathematical model that captures the transition from pairwise interactions to synergetic multiplayer ones. We assume that different social groups have different breaking rates. We show that non-uniform breaking rates do foster the emergence of synergy, even though individuals always interact in pairs. Our work sheds new light on the mechanisms underlying such synergetic interactions. PMID:27466437

  2. Hémophilie: état des lieux dans un service de pédiatrie dans la région de l'oriental du Maroc

    PubMed Central

    Benajiba, Noufissa; Boussaadni, Yousra EL; Aljabri, Mohammed; Bentata, Yassamine; Amrani, Rim; Rkain, Maria

    2014-01-01

    Pour les pays en voie de développement, l'hémophilie continue d’être une maladie de conséquence médicale et sociale désastreuse. Le but de ce travail est d'analyser le suivi d'une cohorte de patients hémophiles. Patients et méthodes: étude prospective étalée sur deux années et menée au centre référent d'hémophilie dans la région de l'orient du Maroc. Ont été inclus tous les patients présentant une hémophilie confirmée et âgé de moins de 18 ans. Résultats: sur 16 hémophiles, Quinze patients présentait une hémophilie A, l’âge moyen des patients était de 6,18 ans, la forme sévère, représentait 20,7%, la forme modérée: 33,3% et la forme mineure: 40%. Les circonstances de découverte étaient post circoncisionnelle chez 53,3% des patients, 20,7% post traumatique, 20% à l’âge de la marche; la durée d’évolution variait entre 2 mois et 10 ans. L'hémarthrose a été décrite au niveau des genoux, coudes et chevilles, avec une moyenne allant de 2 à 5 fois par an; l'arthropathie a été remarquée dans 33,3%. Le bilan immunologique a révélé des facteurs circulant inhibant chez deux patients. Le traitement était à base d'antalgiques, de plasma frais congelé. L'administration de facteurs VIII recombinés a été instaurée chez 40,6% des patients (plus de 90% des formes modérées et graves), grâce au programme national de prise en charge des hémophiles. Le décès était noté dans un seul cas lié à une hémorragie cérébrale. Conclusion: Nous insistons sur l'intérêt du programme national de prise en charge des hémophiles dernièrement instauré qui pourrait améliorer les conditions de vie de ces enfants. PMID:25404986

  3. Morbimortalité périnatale dans les grossesses gémellaires dans une maternité marocaine de niveau 3

    PubMed Central

    Boubkraoui, Mohamed El-Mahdi; Aguenaou, Hassan; Mrabet, Mustapha; Barkat, Amina

    2016-01-01

    Introduction Les grossesses gémellaires sont associées à un risque de morbimortalité périnatale plus élevé que les grossesses simples. Le but de cette étude était d’évaluer la morbimortalité périnatale dans les grossesses gémellaires dans une maternité marocaine de niveau 3. Méthodes Il s'agit d'une étude transversale comparative de la morbimortalité périnatale des nouveau-nés issus de grossesses gémellaires versus grossesses simples ayant accouché à la maternité Souissi de Rabat du 1 janvier au 28 février 2014. Résultats Il y a eu 3297 naissances issues de 65 grossesses gémellaires et 3167 grossesses simples. Les grossesses gémellaires étaient associées à des taux plus élevés de prééclampsie et d’éclampsie (P = 0,046), de HELLP syndrome (P= 0,030), de rupture prématurée des membranes (P < 0,001), de présentation dystocique (P < 0,001), de prématurité (P < 0,001), d'hypotrophie chez les nouveau-nés à terme (P < 0,001), de détresse respiratoire néonatale (P < 0,001), de malformations congénitales (P = 0,015), d'hospitalisation en période néonatale (P = 0,001) et de mortalité périnatale (P = 0,001) par rapport aux grossesses simples. Les jumeaux monochoriaux présentaient des taux plus élevés d'hypotrophie en cas de grossesse menée à terme (P = 0,016) et de mortalité périnatale (P = 0,017) par rapport aux jumeaux bichoriaux. Conclusion Les grossesses gémellaires étaient à risque plus élevé de morbimortalité périnatale par rapport aux grossesses simples en exposant notamment à la prématurité. Les grossesses gémellaires monochoriales étaient plus à risque en exposant notamment à l'hypotrophie chez les nouveau-nés à terme. PMID:27217903

  4. Comparaison de deux scores pronostiques dans les hémorragies digestives hautes non variqueuses dans un centre hospitalier d'Antananarivo

    PubMed Central

    Rakotondrainibe, Aurélia; Randrianambinina, Thierry Pierre; Randriamizao, Harifetra Mamy Richard; Rasoaherinomenjanahary, Fanjandrainy; Randriamiarana, Mialimanana Joël; Samison, Luc Hervé

    2013-01-01

    Il est actuellement recommandé de stratifier les hémorragies digestives hautes, en fonction de leur risque, par des scores pronostiques. L'objectif de cette étude a été d'appliquer ces scores en vue de les comparer, dans un centre hospitalier malgache. Etude prospective sur 419 patients, sur une période entre janvier et décembre 2011, au Centre Hospitalo-Universitaire d'Antananarivo. Les scores de Rockall initial et de Blatchford ont été calculés pour chaque patient présentant une hémorragie digestive haute non variqueuse dont les dossiers été complets, avec notamment la valeur de l'urémie et de l'hémoglobine. Une comparaison de ces deux scores a été faite pour déterminer le pronostic et l’évolution de cette pathologie. 46,3% des dossiers n'avaient pas de valeur d'urémie ni de l'hémoglobine. Les 185 patients retenus, avaient une moyenne d’âge de 48,2 ± 18,2 ans et une prédominance masculine (72,4%). Le risque clinique était élevé dans 62,7% des cas, dont 59,4% ont bénéficié d'une transfusion. Une mortalité de 9,7% a été observée. Le score de Blatchford était plus prédictif du risque clinique par rapport au score de Rockall initial (AUROC = 0,82 vs 0,64; p < 0,0001), mais aussi de la nécessité d'une transfusion (AUROC = 0,79 vs 0,62; p= 0,00013). L'instauration d'un score clinico-biologique est assez limitée par faute de moyens, alors que le score de Blatchford aiderait en matière de pronostic des hémorragies digestives hautes. PMID:24839534

  5. Toward a scientific understanding of the effectiveness, material basis and prescription compatibility of a Chinese herbal formula Dan-hong injection

    PubMed Central

    Li, Panlin; Su, Weiwei; Yun, Sha; Liao, Yiqiu; Liao, Yinyin; Liu, Hong; Li, Peibo; Wang, Yonggang; Peng, Wei; Yao, Hongliang

    2017-01-01

    Since traditional Chinese medicine (TCM) is a complex mixture of multiple components, the application of methodologies for evaluating single-components Western medicine in TCM studies may have certain limitations. Appropriate strategies that recognize the integrality of TCM and connect to TCM theories remain to be developed. Here we use multiple unique approaches to study the scientific connotation of a TCM formula Dan-hong injection (DHI) without undermining its prescription integrity. The blood circulation improving and healing promoting effects of DHI were assessed by a qi stagnation blood stasis rat model and a mouse model of laser irradiation induced cerebral microvascular thrombosis. By UFLC-PDA-Triple Q-TOF-MS/MS and relevance analysis between chemical characters and biological effects, 82 chemical constituents and nine core components, whose blood circulation promoting effects were found comparable to that of whole DHI, were successfully identified. What’s more, the rationality of DHI prescription compatibility could be reflected not only in the maximum efficacy of the original ratio, but also in the interactions of compounds from different ingredient herbs, such as complementary activities and facilitating tissues distribution. This study provides scientific evidences in explanation of the clinical benefits of DHI, and also gives a good demonstration for the comprehensive evaluation of other TCM. PMID:28393856

  6. Mental Health and Well-Being across the Military Spectrum (Bien-etre et sante mentale dans le milieu militaire)

    DTIC Science & Technology

    2011-04-01

    seek help. Implementing the desirable attitude change within a traditionally tough ( macho ) military culture is a real challenge and specific...changement souhaitable de comportement dans un environnement militaire de culture traditionnellement rude ( macho ) est un vrai défi, et il est recommandé

  7. Structure of Gremlin-1 and analysis of its interaction with BMP-2

    PubMed Central

    Kišonaitė, Miglė; Wang, Xuelu; Hyvönen, Marko

    2016-01-01

    Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β (TGF-β) signalling family and has a very broad biological role in development. Its signalling is regulated by many effectors: transmembrane proteins, membrane-attached proteins and soluble secreted antagonists such as Gremlin-1. Very little is known about the molecular mechanism by which Gremlin-1 and other DAN (differential screening-selected gene aberrative in neuroblastoma) family proteins inhibit BMP signalling. We analysed the interaction of Gremlin-1 with BMP-2 using a range of biophysical techniques, and used mutagenesis to map the binding site on BMP-2. We have also determined the crystal structure of Gremlin-1, revealing a similar conserved dimeric structure to that seen in other DAN family inhibitors. Measurements using biolayer interferometry (BLI) indicate that Gremlin-1 and BMP-2 can form larger complexes, beyond the expected 1:1 stoichiometry of dimers, forming oligomers that assemble in alternating fashion. These results suggest that inhibition of BMP-2 by Gremlin-1 occurs by a mechanism that is distinct from other known inhibitors such as Noggin and Chordin and we propose a novel model of BMP-2–Gremlin-1 interaction yet not seen among any BMP antagonists, and cannot rule out that several different oligomeric states could be found, depending on the concentration of the two proteins. PMID:27036124

  8. The Interactive Learning Toolkit: supporting interactive classrooms

    NASA Astrophysics Data System (ADS)

    Dutta, S.; McCauley, V.; Mazur, E.

    2004-05-01

    Research-based interactive learning techniques have dramatically improved student understanding. We have created the 'Interactive Learning Toolkit' (ILT), a web-based learning management system, to help implement two such pedagogies: Just in Time Teaching and Peer Instruction. Our main goal in developing this toolkit is to save the instructor time and effort and to use technology to facilitate the interaction between the students and the instructor (and between students themselves). After a brief review of both pedagogies, we will demonstrate the many exciting new features of the ILT. We will show how technology can not only implement, but also supplement and improve these pedagogies. We would like acknowdge grants from NSF and DEAS, Harvard University

  9. Minimisation de l'effet de la grille collectrice dans une photopile solaire à haute concentration solaire

    NASA Astrophysics Data System (ADS)

    Cheknane, A.; Benyoucef, B.; Charles, J.-P.; Zerdoum, R.

    2005-05-01

    Une fois la croissance cristalline et la jonction sont réalisées, on collecte la puissance électrique délivrée par la photopile au moyen des contacts métalliques déposés sur deux faces. Sur la face arrière il n'y a pas de problèmes particuliers puisque toute la surface peut être utilisée ; la face avant pose essentiellement deux problèmes : Du point de vue optique, le taux de couverture doit être faible car la surface cachée par la métallisation est inactive ; Du point de vue électrique, le drainage des photoporteurs doit se faire avec le minimum de chutes de tension dans le semi-conducteur comme dans le métal. L'objectif de notre travail est de minimiser l'effet de la grille de collecte d'une photopile solaire à homojonction (Si n+p) d'une géométrie circulaire (rayon a=4.9cm), ayant une métallisation à l'argent (ρM=1.610-6 Ω.cm) et une résistance de contact ρC=10-5Ω.cm2. Nos calculs sont faits sous les conditions : AM1.5 et une concentration variant de 1à1000 soleils. Les différentes pertes causées par cette grille sont : - La puissance perdue par l'occultation de la grille (taux d'ombre), - Perte due au contact métal/semi-conducteur, - Puissance dissipée dans la résistance de couche entre barreaux, - Les pertes dans la métallisation de la grille. Nous résumons, dans cet article, les résultats de notre modélisation par : ast Dans l'intervalle [1, 200 soleils] le rendement de conversion varie de 14.7% à 18.1% pour un angle thêta (= 1/2 angle entre deux doigts consécutifs de grille) variant de 0.116 rad à 0.044 rad, ast Dans l'intervalle [ {200,1000 soleils} ] le rendement de conversion varie de 17.8% à 16.98% qui correspond ainsi à une variation de 0.041 rad à 0.026 rad de l'angle thêta.

  10. [Drug-drug interactions: interactions between xenobiotics].

    PubMed

    Haen, E

    2014-04-01

    Drug-drug interactions (DDI) are a major topic in programs for continuous medical education (CME). Many physicians are afraid of being trapped into charges of malpractice; however, DDI cannot be avoided in many cases. They belong to routine medical practice and it is often impossible to avoid them. Moreover, they do not just occur between drugs but between any kind of foreign substance (xenobiotica), such as food (e.g. grapefruit juice, broccoli, barbecue) as well as legal (e.g. tobacco smoke, caffeine and alcohol) and illegal drugs. Therefore, the medical challenge is not just to avoid any interaction. Instead the physician faces the question of how to proceed with drug treatment in the presence of such interactions. Based on the medical education a physician has to judge first of all whether there is a risk for interactions in the prescription being planned for an individual patient. The classification of interactions proposed in this article (PD1-PD4, PK1-PK3) might help as a sort of check list. For more detailed information the physician can then consult one of the many databases available on the internet, such as PSIAConline (http://www.psiac.de) and MediQ (http://www.mediq.ch). Pharmacokinetic interactions can be easily assessed, monitored and controlled by therapeutic drug monitoring (TDM). Besides these tools it is important to keep in mind that nobody knows everything; even physicians do not know everything. So take pride in asking someone who might help and for this purpose AGATE offers a drug information service AID (http://www.amuep-agate.de). Just good for nothing, without being based on any kind of medical approach are computer programs that judge prescriptions without taking into account a patient's individual peculiarities. In case these types of programs produce red exclamation marks or traffic lights to underline their judgment, they might even work in a contrapuntal way by just eliciting insecurity and fear.

  11. Hygrothermal Effects in Continuous Fibre Reinforced Composites. Part I. Thermal and Moisture Diffusion in Composite Materials (Effets Hygrothermiques dans les Composites a Renfort de Fibre Continu. Partie I. Diffusion de L’Humidite et de la Chaleur dans les Materiaux Composites)

    DTIC Science & Technology

    1983-01-01

    HYGROTHERMIQUES DANS LES COMPOSITES A RENFORT DE FIBRE CONTINU PARTIE I - DIFFUSION DE L’HUMIDITE ET DE LA CHALEUR DANS LES MATERIAUX COMPOSITES by/par J.P...structures for space- craft hardware)[223]. Composite materials are often subjected to fatigue loads and should exhibit impact strength and shock resistance

  12. The interactive brain hypothesis

    PubMed Central

    Di Paolo, Ezequiel; De Jaegher, Hanne

    2012-01-01

    Enactive approaches foreground the role of interpersonal interaction in explanations of social understanding. This motivates, in combination with a recent interest in neuroscientific studies involving actual interactions, the question of how interactive processes relate to neural mechanisms involved in social understanding. We introduce the Interactive Brain Hypothesis (IBH) in order to help map the spectrum of possible relations between social interaction and neural processes. The hypothesis states that interactive experience and skills play enabling roles in both the development and current function of social brain mechanisms, even in cases where social understanding happens in the absence of immediate interaction. We examine the plausibility of this hypothesis against developmental and neurobiological evidence and contrast it with the widespread assumption that mindreading is crucial to all social cognition. We describe the elements of social interaction that bear most directly on this hypothesis and discuss the empirical possibilities open to social neuroscience. We propose that the link between coordination dynamics and social understanding can be best grasped by studying transitions between states of coordination. These transitions form part of the self-organization of interaction processes that characterize the dynamics of social engagement. The patterns and synergies of this self-organization help explain how individuals understand each other. Various possibilities for role-taking emerge during interaction, determining a spectrum of participation. This view contrasts sharply with the observational stance that has guided research in social neuroscience until recently. We also introduce the concept of readiness to interact to describe the practices and dispositions that are summoned in situations of social significance (even if not interactive). This latter idea links interactive factors to more classical observational scenarios. PMID:22701412

  13. Use Cases for Dynamic Secure Wireless Networking in Coalition Environments (Cas d utilisation de r seau sans fil dynamique et s curis dans des environnements de coalition)

    DTIC Science & Technology

    2015-05-01

    sécurisé dans des environnements de coalition) This Report documents the findings of Task Group IST-109/RTG-054. Published May 2015 Distribution...d’utilisation de réseau sans fil dynamique et sécurisé dans des environnements de coalition) This Report documents the findings of Task Group IST...dynamique et sécurisé dans des environnements de coalition (STO-TR-IST-109) Synthèse Les réseaux sans fil mobiles et dynamiques utilisent des

  14. Assessment of trace element impacts on agricultural use of water from the Dan River following the Eden coal ash release.

    PubMed

    Hesterberg, Dean; Polizzotto, Matthew L; Crozier, Carl; Austin, Robert E

    2016-04-01

    Catastrophic events require rapid, scientifically sound decision making to mitigate impacts on human welfare and the environment. The objective of this study was to analyze potential impacts of coal ash-derived trace elements on agriculture following a 35,000-tonne release of coal ash into the Dan River at the Duke Energy Steam Station in Eden, North Carolina. We performed scenario calculations to assess the potential for excessive trace element loading to soils via irrigation and flooding with Dan River water, uptake of trace elements by crops, and livestock consumption of trace elements via drinking water. Concentrations of 13 trace elements measured in Dan River water samples within 4 km of the release site declined sharply after the release and were equivalent within 5 d to measurements taken upriver. Mass-balance calculations based on estimates of soil trace-element concentrations and the nominal river water concentrations indicated that irrigation or flooding with 25 cm of Dan River water would increase soil concentrations of all trace elements by less than 0.5%. Calculations of potential increases of trace elements in corn grain and silage, fescue, and tobacco leaves suggested that As, Cr, Se, Sr, and V were elements of most concern. Concentrations of trace elements measured in river water following the ash release never exceeded adopted standards for livestock drinking water. Based on our analyses, we present guidelines for safe usage of Dan River water to diminish negative impacts of trace elements on soils and crop production. In general, the approach we describe here may serve as a basis for rapid assessment of environmental and agricultural risks associated with any similar types of releases that arise in the future.

  15. The effects of dan-shen root on cardiomyogenic differentiation of human placenta-derived mesenchymal stem cells

    SciTech Connect

    Li, Kun; Li, Shi-zheng; Zhang, Yun-li; Wang, Xue-zhe

    2011-11-11

    Highlights: Black-Right-Pointing-Pointer Conditional medium and dan-shen root were used for cardiomyogenic differentiation. Black-Right-Pointing-Pointer They all could induce hPDMSCs to differentiate into cardiomyocytes. Black-Right-Pointing-Pointer The induction effect of the latter was slightly higher compared to that of the former. Black-Right-Pointing-Pointer Dan-shen root could be a good inducer for cardiomyogenic differentiation. -- Abstract: The aim of this study was to search for a good inducer agent using for cardiomyogenic differentiation of stem cells. Human placenta-derived mesenchymal stem cells (hPDMSCs) were isolated and incubated in enriched medium. Fourth passaged cells were treated with 10 mg/L dan-shen root for 20 days. Morphologic characteristics were analyzed by confocal and electron microscopy. Expression of {alpha}-sarcomeric actin was analyzed by immunohistochemistry. Expression of cardiac troponin-I (TnI) was analyzed by immunohistofluorescence. Atrial natriuretic factor (ANF) and beta-myocin heavy chain ({beta}-MHC) were detected by reverse transcriptase polymerase chain reaction (RT-PCR). hPDMSCs treated with dan-shen root gradually formed a stick-like morphology and connected with adjoining cells. On the 20th day, most of the induced cells stained positive with {alpha}-sarcomeric actin and TnI antibody. ANF and {beta}-MHC were also detected in the induced cells. Approximately 80% of the cells were successfully transdifferentiated into cardiomyocytes. In conclusion, dan-shen root is a good inducer agent used for cardiomyogenic differentiation of hPDMSCs.

  16. How Interactive Is the Interactive Whiteboard?

    ERIC Educational Resources Information Center

    Quashie, Valerie

    2009-01-01

    An interactive whiteboard (IWB) is simply a surface onto which a computer screen can be displayed, via a projector. It is touch-sensitive and lets one use a pen like a mouse, controlling the computer from the board itself. Everything that can be displayed on a computer can be displayed onto the whiteboard and, if the computer is linked to speakers…

  17. Food-drug interactions.

    PubMed

    Bushra, Rabia; Aslam, Nousheen; Khan, Arshad Yar

    2011-03-01

    The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or another disease the person has (drug-disease interaction). A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own. These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances. Regarding food-drug interactions physicians and pharmacists recognize that some foods and drugs, when taken simultaneously, can alter the body's ability to utilize a particular food or drug, or cause serious side effects. Clinically significant drug interactions, which pose potential harm to the patient, may result from changes in pharmaceutical, pharmacokinetic, or pharmacodynamic properties. Some may be taken advantage of, to the benefit of patients, but more commonly drug interactions result in adverse drug events. Therefore it is advisable for patients to follow the physician and doctors instructions to obtain maximum benefits with least food-drug interactions. The literature survey was conducted by extracting data from different review and original articles on general or specific drug interactions with food. This review gives information about various interactions between different foods and drugs and will help physicians and pharmacists prescribe drugs cautiously with only suitable food supplement to get maximum benefit for the patient.

  18. Stabilisation de poussieres de four a arc electrique dans les matrices cimentaires

    NASA Astrophysics Data System (ADS)

    Laforest, Guylaine

    L'etude de la stabilisation des poussieres de four a arc electrique (EAFD) par le laitier de haut-fourneau (GGBFS) et le ciment Portland (OPC) a ete realisee en trois parties. D'abord, la problematique de fixation du Cr dans les matrices cimentaires a ete etudiee en soumettant differents liants a des solutions de Cr lors d'essais de lixiviation en vrac et d'essais d'isothermes d'absorption. Ensuite, la caracterisation des EAFD a ete effectuee. Finalement, la stabilisation des EAFD dans les matrices cimentaires a ete etudiee en soumettant differents melanges liant-EAFD a des essais de lixiviation en vrac, de competition ionique, de solubilisation a differents pH et de lixiviation sur monolithes. Les resultats ont demontre que le OPC et le GGBFS sont efficaces pour la fixation du Cr. Les silicates de calcium hydrates, la chromatite et l'hydrocalumite ont ete identifiees comme etant des phases jouant un role dans la fixation du Cr. Les EAFD ont montre une mineralogie complexe, heterogene, riche en spinelles et oxydes metalliques. Un important pourcentage des metaux lourds (Cr, Zn, Ni et Pb) des EAFD a ete identifie lixiviable. Les EAFD etablissent un controle de solubilite sur ces metaux, mais ce controle n'est pas suffisant pour diminuer les concentrations en metaux du lixiviat sous les limites permises. Ainsi, les resulats des essais sur la stabilisation des EAFD ont demontre qu'il etait possible, avec le OPC et le GGBFS, de diminuer les concentrations en metaux lourds des lixiviats sous les limites acceptees. Les phases incorporant les metaux, ((Ni,Zn)Fe2O4, (Zn,Mo)O, Ni(OH)2 et Pb(OH) 2), ont ete determinees par SEM, XRD et par modelisation geochimique. L'hydrocalumite et le Cr(VI)-ettringite ont ete etablies comme etant des phases potentiellement capables de fixer le Cr. L'etude de la competition ionique a montre que la fixation du Cr par le GGBFS diminue legerement en presence du Pb. L'etude des monolithes, composes de EAFD et de OPC ou GGBFS et soumis a une

  19. First results from the CheMin, DAN and SAM instruments on Mars Science Laboratory

    NASA Astrophysics Data System (ADS)

    Blake, D. F.; Mahaffy, P. R.; Mitrofanov, I.

    2012-12-01

    One of the principal goals of the Mars Science Laboratory rover Curiosity is to identify and characterize the early habitable environments of Mars, as recorded in the stratified rocks and soil of Gale crater. The suite of instruments aboard Curiosity will make measurements useful for determining the presence and lateral/vertical distribution of hydrated phases, the mineralogy and "preservation potential" of sediments and rocks, and the identity and isotopic composition of organic and other carbon containing molecules, should such be present. Three of Curiosity's instruments, DAN ("Dynamic Albedo of Neutrons," a soil hydrogen detector), CheMin ("Chemistry and Mineralogy," a mineralogy instrument) and SAM ("Surface Analysis at Mars," an organic molecule and isotopic analysis instrument) are uniquely suited to this purpose. DAN consists of a pulsed neutron generator and neutron detector that will measure the hydrogen content (i.e., hydrated phases, water ice) in the upper meter of the soil. Both passive and active measurements will be obtained, resulting in a meter-scale resolution transect map of near-surface hydrogen along the path of the rover. These measurements will provide context for the mineralogical and organic measurements of drilled and scooped samples analyzed by CheMin and SAM. CheMin, a powder X-ray Diffraction (pXRD) instrument, will determine the mineralogy of scooped soils and powders obtained from drilled rocks. Hydrated minerals will be identified, along with whole-rock mineralogy for characterizing the environment of formation and preservation potential for organic molecules. SAM consists of a sample handling system, a gas chromatograph, a mass spectrometer, and a tunable laser spectrometer. SAM will accept the same powdered rock and soil samples as CheMin, and will measure and identify organic carbon in these samples as well as evolved inorganic gases such as CO2, CH4, and H2O. Isotopic composition of noble gases and several light elements are

  20. Profil de l'infection urinaire nosocomiale dans un service de nephrology

    PubMed Central

    Lazrak, Mohamed Amine; El Bardai, Ghita; Jaafour, Soumia; Kabbali, Nadia; Arrayhani, Mohamed; Houssaini, Tarik Sqalli

    2014-01-01

    L'infection urinaire est l'infection nosocomiale la plus fréquente. Elle constitue un véritable problème de santé publique par la surmortalité et le surcoût qu'elle entraîne. L'objectif de notre étude est de déterminer l'incidence et le profil des IU nosocomiales dans un service de Néphrologie. Etude rétrospective sur dossier de tous les patients hospitalisés dans notre service durant l'année 2011, ayant bénéficié d'un examen cytobactériologique des urines. Ont été exclus, tous les patients admis avec une IU connue ou active. 325 dossiers ont été retenus. L'incidence de l'IU nosocomiale était de l'ordre de 16,9%. La durée moyenne d'hospitalisation était de 14,1±10,15 jours. 30% de nos patients ont été transférés du service des urgences. 80% des IU nosocomiales étaient compliquées. Le germe responsable était E.Coli dans 2/3 des cas dont 14,5% était à E.Coli sécrétrice de bétalactamases à spectre étendu. L’évolution après traitement était favorable chez 90,7%. En analyse multivariée, les facteurs de risque pour contracter une IU nosocomiale étaient le sexe féminin; le sondage urinaire et l'antécédent d'IU à répétition. Nos résultats rejoignent ceux de la littérature concernant les facteurs de risque liés à la survenue de l'IU nosocomiale, la fréquence des infections à entérobactéries, et l’émergence de souches résistantes. Une Surveillance microbiologique et une évaluation de la résistance aux antibiotiques constituent une ligne de défense pour faire face à l'accentuation de nouvelles souches bactériennes de plus en plus résistantes aux antibiotiques rendant les options thérapeutiques très limitées. PMID:25667721

  1. Dispositif de mesure calorimétrique des pertes dans les condensateurs de puissance

    NASA Astrophysics Data System (ADS)

    Seguin, B.; Gosse, J. P.

    1997-02-01

    A calorimetric technique is used to measure the power losses in capacitors. The power dissipated in the component is measured as the difference between the heat powers delivered by a temperature regulation when the capacitor is energetized or not. The original feature of the apparatus lies in the use of the isothermal calorimetry and in the measurement of an electrical power, in condradistinction with previous and dissatisfacting attempts based on the measurement of a temperature increase. The result is an improvement of the accuracy and sensibility of the apparatus which can be used to determine the equivalent series resistance of capacitors having very low losses. Measurements realized on a polypropylene capacitor and a sinusoidal applied voltage have allowed us to separate the ohmic losses from the dielectric ones and to study their variations with temperature. Une technique de calorimétrie isotherme est appliquée à la mesure des pertes électriques dans les condensateurs. La puissance calorifique dissipée par le composant est mesurée comme la différence des puissances de chauffe délivrées par une régulation de température quand le condensateur est hors tension ou sous tension. L'originalité du dispositif réside dans l'utilisation du principe de calorimétrie isotherme et dans la nature de la grandeur physique mesurée qui est une puissance électrique alors que les tentatives antérieures de mesures calorimétriques reposaient sur la mesure d'une élévation de température. Il en résulte une amélioration de la précision et de la sensibilité de ce type d'appareillage qui peut être employé pour caractériser la résistance série équivalente des condensateurs à très faibles pertes. Une série de mesures, réalisée sur un condensateur au polypropylène soumis à une tension sinusoïdale, a permis de séparer les pertes ohmiques des pertes diélectriques et d'étudier leurs variations avec la température.

  2. LSD and DOB: interaction with 5-HT2A receptors to inhibit NMDA receptor-mediated transmission in the rat prefrontal cortex.

    PubMed

    Arvanov, V L; Liang, X; Russo, A; Wang, R Y

    1999-09-01

    Both the phenethylamine hallucinogen (-)-1-2, 5-dimethoxy-4-bromophenyl-2-aminopropane (DOB), a selective serotonin 5-HT2A,2C receptor agonist, and the indoleamine hallucinogen D-lysergic acid diethylamide (LSD, which binds to 5-HT1A, 1B, 1D, 1E, 1F, 2A, 2C, 5, 6, 7, dopamine D1 and D2, and alpha1 and alpha2 adrenergic receptors), but not their non-hallucinogenic congeners, inhibited N-methyl-D-aspartate (NMDA)-induced inward current and NMDA receptor-mediated synaptic responses evoked by electrical stimulation of the forceps minor in pyramidal cells of the prefrontal cortical slices. The inhibitory effect of hallucinogens was mimicked by 5-HT in the presence of selective 5-HT1A and 5-HT3 receptor antagonists. The inhibitory action of DOB, LSD and 5-HT on the NMDA transmission was blocked by the 5-HT2A receptor antagonists R-(+)-alpha-(2, 3-dimethoxyphenil)-1-[4-fluorophenylethyl]-4-piperidineme thanol (M100907) and ketanserin. However, at low concentrations, when both LSD and DOB by themselves only partially depressed the NMDA response, they blocked the inhibitory effect of 5-HT, suggesting a partial agonist action. Whereas N-(4-aminobutyl)-5-chloro-2-naphthalenesulphonamide (W-7, a calmodulin antagonist) and N-[2-[[[3-(4'-chlorophenyl)- 2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxy-b enzenesulphonamide phosphate (KN-93, a Ca2+/CaM-KII inhibitor), but not the negative control 2-[N-4'methoxybenzenesulphonyl]amino-N-(4'-chlorophenyl)-2-propeny l-N -methylbenzylamine phosphate (KN-92), blocked the inhibitory action of LSD and DOB, the selective protein kinase C inhibitor chelerythrine was without any effect. We conclude that phenethylamine and indoleamine hallucinogens may exert their hallucinogenic effect by interacting with 5-HT2A receptors via a Ca2+/CaM-KII-dependent signal transduction pathway as partial agonists and modulating the NMDA receptors-mediated sensory, perceptual, affective and cognitive processes.

  3. Food and Drug Interactions

    PubMed Central

    Choi, Jong Hwan; Ko, Chang Mann

    2017-01-01

    Natural foods and vegetal supplements have recently become increasingly popular for their roles in medicine and as staple foods. This has, however, led to the increased risk of interaction between prescribed drugs and the bioactive ingredients contained in these foods. These interactions range from pharmacokinetic interactions (absorption, distribution, metabolism, and excretion influencing blood levels of drugs) to pharmacodynamic interactions (drug effects). In a quantitative respect, these interactions occur mainly during metabolism. In addition to the systemic metabolism that occurs mainly in the liver, recent studies have focused on the metabolism in the gastrointestinal tract endothelium before absorption. Inhibition of metabolism causes an increase in the blood levels of drugs and could have adverse reactions. The food-drug interactions causing increased blood levels of drugs may have beneficial or detrimental therapeutic effects depending on the intensity and predictability of these interactions. It is therefore important to understand the potential interactions between foods and drugs should and the specific outcomes of such interactions. PMID:28261555

  4. The Science of Interaction

    SciTech Connect

    Pike, William A.; Stasko, John T.; Chang, Remco; O'Connell, Theresa

    2009-09-23

    There is a growing recognition with the visual analytics community that interaction and inquiry are inextricable. It is through the interactive manipulation of a visual interface – the analytic discourse – that knowledge is constructed, tested, refined, and shared. This paper reflects on the interaction challenges raised in the original visual analytics research and development agenda and further explores the relationship between interaction and cognition. It identifies recent exemplars of visual analytics research that have made substantive progress toward the goals of a true science of interaction, which must include theories and testable premises about the most appropriate mechanisms for human-information interaction. Six areas for further work are highlighted as those among the highest priorities for the next five years of visual analytics research: ubiquitous, embodied interaction; capturing user intentionality; knowledge-based interfaces; principles of design and perception; collaboration; and interoperability. Ultimately, the goal of a science of interaction is to support the visual analytics community through the recognition and implementation of best practices in the representation of and interaction with visual displays.

  5. Two interacting Hofstadter butterflies

    SciTech Connect

    Barelli, A.; Bellissard, J.; Jacquod, P.; Shepelyansky, D.L.

    1997-04-01

    The problem of two interacting particles in a quasiperiodic potential is addressed. Using analytical and numerical methods, we explore the spectral properties and eigenstates structure from the weak to the strong interaction case. More precisely, a semiclassical approach based on noncommutative geometry techniques is used to understand the intricate structure of such a spectrum. An interaction induced localization effect is furthermore emphasized. We discuss the application of our results on a two-dimensional model of two particles in a uniform magnetic field with on-site interaction. {copyright} {ital 1997} {ital The American Physical Society}

  6. Gender interactions and success.

    PubMed

    Wiggins, Carla; Peterson, Teri

    2004-01-01

    Does gender by itself, or does gender's interaction with career variables, better explain the difference between women and men's careers in healthcare management? US healthcare managers were surveyed regarding career and personal experiences. Gender was statistically interacted with explanatory variables. Multiple regression with backwards selection systematically removed non-significant variables. All gender interaction variables were non-significant. Much of the literature proposes that work and career factors impact working women differently than working men. We find that while gender alone is a significant predictor of income, it does not significantly interact with other career variables.

  7. Reconceptualizing sex, brain and psychopathology: interaction, interaction, interaction

    PubMed Central

    Joel, D; Yankelevitch-Yahav, R

    2014-01-01

    In recent years there has been a growing recognition of the influence of sex on brain structure and function, and in relation, on the susceptibility, prevalence and response to treatment of psychiatric disorders. Most theories and descriptions of the effects of sex on the brain are dominated by an analogy to the current interpretation of the effects of sex on the reproductive system, according to which sex is a divergence system that exerts a unitary, overriding and serial effect on the form of other systems. We shortly summarize different lines of evidence that contradict aspects of this analogy. The new view that emerges from these data is of sex as a complex system whose different components interact with one another and with other systems to affect body and brain. The paradigm shift that this understanding calls for is from thinking of sex in terms of sexual dimorphism and sex differences, to thinking of sex in terms of its interactions with other factors and processes. Our review of data obtained from animal models of psychopathology clearly reveals the need for such a paradigmatic shift, because in the field of animal behaviour whether a sex difference exists and its direction depend on the interaction of many factors including, species, strain, age, specific test employed and a multitude of environmental factors. We conclude by explaining how the new conceptualization can account for sex differences in psychopathology. Linked Articles This article is part of a themed section on Animal Models in Psychiatry Research. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-20 PMID:24758640

  8. Drug-nutrient interactions.

    PubMed

    Chan, Lingtak-Neander

    2013-07-01

    Drug-nutrient interactions are defined as physical, chemical, physiologic, or pathophysiologic relationships between a drug and a nutrient. The causes of most clinically significant drug-nutrient interactions are usually multifactorial. Failure to identify and properly manage drug-nutrient interactions can lead to very serious consequences and have a negative impact on patient outcomes. Nevertheless, with thorough review and assessment of the patient's history and treatment regimens and a carefully executed management strategy, adverse events associated with drug-nutrient interactions can be prevented. Based on the physiologic sequence of events after a drug or a nutrient has entered the body and the mechanism of interactions, drug-nutrient interactions can be categorized into 4 main types. Each type of interaction can be managed using similar strategies. The existing data that guide the clinical management of most drug-nutrient interactions are mostly anecdotal experience, uncontrolled observations, and opinions, whereas the science in understanding the mechanism of drug-nutrient interactions remains limited. The challenge for researchers and clinicians is to increase both basic and higher level clinical research in this field to bridge the gap between the science and practice. The research should aim to establish a better understanding of the function, regulation, and substrate specificity of the nutrient-related enzymes and transport proteins present in the gastrointestinal tract, as well as assess how the incidence and management of drug-nutrient interactions can be affected by sex, ethnicity, environmental factors, and genetic polymorphisms. This knowledge can help us develop a true personalized medicine approach in the prevention and management of drug-nutrient interactions.

  9. Analyte interactions with a new ditopic dansylamide-nitrobenzoxadiazole dyad: a combined photophysical, NMR, and theoretical (DFT) study.

    PubMed

    Bhoi, Abhas Kumar; Das, Sudhir Kumar; Majhi, Debashis; Sahu, Prabhat Kumar; Nijamudheen, A; N, Anoop; Rahaman, Abdur; Sarkar, Moloy

    2014-08-21

    We report herein the synthesis and photophysical studies on a new multicomponent chemosensor dyad comprising two fluorescing units, dansylamide (DANS) and nitrobenzoxadiazole (NBD). The system has been developed to investigate receptor-analyte binding interactions in the presence of both cations and anions in a single molecular system. A dimethyl amino (in the DANS unit) group is used as a receptor for cations, and acidic hydrogens of sulfonamide and the NBD group are used as receptors for anions. The system is characterized by conventional analytical techniques. The photophysical properties of this supramolecular system in the absence and presence of various metal ions and nonmetal ions as additives are investigated in an acetonitrile medium. Utility of this system in an aqueous medium has also been demonstrated. The absorption and fluorescence spectrum of the molecular system consists of a broad band typical of an intramolecular charge-transfer (ICT) transition. A low quantum yield and lifetime of the NBD moiety in the present dyad indicates photoinduced electron transfer (PET) between DANS and the NBD moiety. The fluorescence intensity of the system is found to decrease in the presence of fluoride and acetate anions; however, the quenching is found to be much higher for fluoride. This quenching behavior is attributed to the enhanced PET from the anion receptor to the fluorophore moiety. The mechanistic aspect of the fluoride ion signaling behavior has also been studied by infrared (IR) and (1)H NMR experiments. The hydrogen bonding interaction between the acidic NH protons of the DPN moiety and F(-) is found to be primarily responsible for the fluoride selective signaling behavior. While investigating the cation signaling behavior, contrary to anions, significant fluorescence enhancement has been observed only in the presence of transition-metal ions. This behavior is rationalized by considering the disruption of PET communication between DANS and the NBD moiety

  10. Hydrocarbon Source Rocks in the Deep River and Dan River Triassic Basins, North Carolina

    USGS Publications Warehouse

    Reid, Jeffrey C.; Milici, Robert C.

    2008-01-01

    This report presents an interpretation of the hydrocarbon source rock potential of the Triassic sedimentary rocks of the Deep River and Dan River basins, North Carolina, based on previously unpublished organic geochemistry data. The organic geochemical data, 87 samples from 28 drill holes, are from the Sanford sub-basin (Cumnock Formation) of the Deep River basin, and from the Dan River basin (Cow Branch Formation). The available organic geochemical data are biased, however, because many of the samples collected for analyses by industry were from drill holes that contained intrusive diabase dikes, sills, and sheets of early Mesozoic age. These intrusive rocks heated and metamorphosed the surrounding sediments and organic matter in the black shale and coal bed source rocks and, thus, masked the source rock potential that they would have had in an unaltered state. In places, heat from the intrusives generated over-mature vitrinite reflectance (%Ro) profiles and metamorphosed the coals to semi-anthracite, anthracite, and coke. The maximum burial depth of these coal beds is unknown, and depth of burial may also have contributed to elevated thermal maturation profiles. The organic geochemistry data show that potential source rocks exist in the Sanford sub-basin and Dan River basin and that the sediments are gas prone rather than oil prone, although both types of hydrocarbons were generated. Total organic carbon (TOC) data for 56 of the samples are greater than the conservative 1.4% TOC threshold necessary for hydrocarbon expulsion. Both the Cow Branch Formation (Dan River basin) and the Cumnock Formation (Deep River basin, Sanford sub-basin) contain potential source rocks for oil, but they are more likely to have yielded natural gas. The organic material in these formations was derived primarily from terrestrial Type III woody (coaly) material and secondarily from lacustrine Type I (algal) material. Both the thermal alteration index (TAI) and vitrinite reflectance data

  11. [Analysis on Cheng Dan-an's educational thought in his book Chinese acupuncturology].

    PubMed

    Zhang, Chao-nan; Huang, Xue-kuan; Luo, Yan; Jiang, Juan; Wan, Lei; Wang, Ling

    2014-10-01

    Mr. CHENG Dan-an, a famous acupuncture master, is the beginner of "Chengjiang Acupuncturological School" in China. This school of thought has a far-reaching impact on current acupunturological education,and its educational thought and teaching features chiefly reflect in CHENG's works. In the present paper, the authors analyze the influence of contemporary historical factors and sum up Mr. CHENG's educational thought on the basis of the written foundation, style and contents of his book Chinese Acupuncturology from four aspects (1) the role of education, (2) the process of education, (3) the teacher's and students' relationship in educational activities,and (4) the compilation of teaching materials about acupuncture and moxibustion.

  12. Bruit thermique et effets quantiques dans une cavité optique de grande finesse

    NASA Astrophysics Data System (ADS)

    Caniard, T.; Briant, T.; Heidmann, A.; Pinard, M.

    2006-10-01

    Nous nous intéressons aux bruits dans les mesures optiques de très grande sensibilité et aux limites associées. Une des limitations fondamentales des mesures interférométriques, telles que les détections d'ondes gravitationnelles, est liée aux fluctuations de la pression de radiation exercée par la lumière sur les miroirs. Celle-ci induit des corrélations quantiques entre la position des miroirs et les fluctuations de la lumière. L'observation de ces effets quantiques ouvrirait de nombreuses perspectives: étude de la limite quantique standard, production d'états comprimés, réalisation d'une mesure quantique non destructive ldots

  13. Visualizing Dispersion Interactions

    ERIC Educational Resources Information Center

    Gottschalk, Elinor; Venkataraman, Bhawani

    2014-01-01

    An animation and accompanying activity has been developed to help students visualize how dispersion interactions arise. The animation uses the gecko's ability to walk on vertical surfaces to illustrate how dispersion interactions play a role in macroscale outcomes. Assessment of student learning reveals that students were able to develop…

  14. University-industry interaction

    NASA Technical Reports Server (NTRS)

    Hastings, Daniel E.

    1990-01-01

    It is posited that university industry interaction is highly desirable from the viewpoint of the long term economic development of the country as well as being desirable for the Space Grant Programs. The present and future possible interactions are reviewed for the three university levels namely, undergraduate, graduate, and faculty research.

  15. Interactive Visualization of Dependencies

    ERIC Educational Resources Information Center

    Moreno, Camilo Arango; Bischof, Walter F.; Hoover, H. James

    2012-01-01

    We present an interactive tool for browsing course requisites as a case study of dependency visualization. This tool uses multiple interactive visualizations to allow the user to explore the dependencies between courses. A usability study revealed that the proposed browser provides significant advantages over traditional methods, in terms of…

  16. Storyboarding Multimedia Interactions.

    ERIC Educational Resources Information Center

    Martin, Linda C.

    2000-01-01

    Understanding how to include interactivity when designing multimedia-based training (MBT) storyboards is a major key for a successful MBT. Discusses the basic formats of interactions and when to use each format. Describes how to storyboard and areas to address, including: the display area, prompts, branching, programming and graphics notes,…

  17. Interactive Presentation of Content

    ERIC Educational Resources Information Center

    Magdin, Martin; Turcáni, Milan; Vrábel, Marek

    2009-01-01

    In the paper we discus about design of universal environment for solution of creating effective multimedia applications with accent on the implementation of interactive elements with the possibility of using the adaptive systems (AS). We also discuss about possibilities of offline presentation of this interactive multimedia adaptive animations…

  18. Interactive TV: The Sequel.

    ERIC Educational Resources Information Center

    Brown, Eric

    1998-01-01

    Examines the future of interactive TV where consumers navigate the Internet on their TVs with WebTV set-top boxes. Focuses on competition between cable companies and computer and consumer electronics companies. Highlights nine companies and partnerships developing interactive hardware and services. (PEN)

  19. Normal Shock Vortex Interaction

    DTIC Science & Technology

    2003-03-01

    Figure 9: Breakdown map for normal-shock vortex-interaction. References [1] O. Thomer, W. Schroder and M. Meinke , Numerical Simulation of Normal...and Oblique-Shock Vortex Interaction, ZAMM Band 80, Sub. 1, pp. 181-184, 2000. [2] O. Thomer, E. Krause, W. Schroder and M. Meinke , Computational

  20. Let Social Interaction Flourish

    ERIC Educational Resources Information Center

    Case, Anny Fritzen

    2016-01-01

    The author describes lessons learned--through a high school project that grouped English language learners with native speakers to create a video--about ways to foster respectful, productive interaction among English learners and peers who are native speakers. The potential benefits of students who are just learning English interacting socially…

  1. Elementary particle interactions

    SciTech Connect

    Bugg, W.M.; Condo, G.T.; Handler, T.; Hart, E.L.; Ward, B.F.L.; Close, F.E.; Christophorou, L.G.

    1990-10-01

    This report discusses freon bubble chamber experiments exposed to {mu}{sup +} and neutrinos, photon-proton interactions; shower counter simulations; SLD detectors at the Stanford Linear Collider, and the detectors at the Superconducting Super Collider; elementary particle interactions; physical properties of dielectric materials used in High Energy Physics detectors; and Nuclear Physics. (LSP)

  2. Anomalies de Résistivité dans Certains Métaux Magnétiques

    NASA Astrophysics Data System (ADS)

    de Gennes, P. G.; Friedel, J.

    La résistivité anormale de certaines terres rares et des alliages tels que AuMn, Au3Mn, est interpretée en admettant qu'il existe un couplage d'échange entre électrons de conduction et porteurs de magnétisme. La valeur absolue de la section efficace correspondante est traitée comme une quantité phénomènologique. Aux températures élevées, les spins atomiques sont orientés au hasard, et les électrons de conduction ont un libre parcours moyen fini. Aux basses températures, les moments atomiques sont tous alignés et ne diffusent plus les électrons. Les effets d'ordre à courte distance sont analysés dans les limites de l'approximation de BORN. Its sont petits dans la plupart des cas physiques. The anomalous resistivity of some rare earth metals, and of alloys like AuMn, Au3Mn, is studied by assuming a coupling between conduction electrons and atomic spins. The magnitude of the corresponding cross section is treated as a phenomenological quantity. At high temperatures, the atomic spins are at random, and the conduction electrons have a finite mean free path. At low temperatures, the atomic spins are all alined and no scattering can occur. Short-range order effects in the spin lattice are analysed in the Born approximation, and shown to be small in most physical situations.

  3. Spacelab user interaction

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The results of the third and final phase of a study undertaken to define means of optimizing the Spacelab experiment data system by interactively manipulating the flow of data were presented. A number of payload applicable interactive techniques and an integrated interaction system for each of two possible payloads are described. These interaction systems have been functionally defined and are accompanied with block diagrams, hardware specifications, software sizing and speed requirements, operational procedures and cost/benefits analysis data for both onboard and ground based system elements. It is shown that accrued benefits are attributable to a reduction in data processing costs obtained by, generally, a considerable reduction in the quantity of data that might otherwise be generated without interaction. One other additional anticipated benefit includes the increased scientific value obtained by the quicker return of all useful data.

  4. Venus: Interaction with Solar Wind

    NASA Astrophysics Data System (ADS)

    Russell, C.; Luhmann, J.; Murdin, P.

    2002-07-01

    The solar wind interaction with VENUS provides the archetypal interaction of a flowing magnetized PLASMA with a PLANETARY IONOSPHERE. Mars interacts with the solar wind in much the same way as does Venus, while the rotating plasma in the Saturnian magnetosphere is believed to interact similarly with its moon, Titan (see SATURN: MAGNETOSPHERE INTERACTION WITH TITAN). The interaction of the Jovian ...

  5. The ADAMS interactive interpreter

    SciTech Connect

    Rietscha, E.R.

    1990-12-17

    The ADAMS (Advanced DAta Management System) project is exploring next generation database technology. Database management does not follow the usual programming paradigm. Instead, the database dictionary provides an additional name space environment that should be interactively created and tested before writing application code. This document describes the implementation and operation of the ADAMS Interpreter, an interactive interface to the ADAMS data dictionary and runtime system. The Interpreter executes individual statements of the ADAMS Interface Language, providing a fast, interactive mechanism to define and access persistent databases. 5 refs.

  6. Cefuroxime antacid interactions.

    PubMed

    Sultana, N; Mubeen, T; Arayne, M S; Ifzal, R

    2001-01-01

    Cefuroxime sodium a second generation semi-synthetic cephalosporin is effective for treating meningitis, lower respiratory tract infections, gonorrhea, bone and joint infections and is approved for surgical prophylaxis. There are number of synergistic and as well as antagonistic drug interactions reported for this antibiotic. Withstanding to gastric irritations caused by this antibiotic, antacids may possibly be co-administered with cefuroxime, which may result in severe adverse drug interaction. The present work describes the effect of magnesium carbonate, magnesium hydroxide, magnesium trisilicate, megaldrate powder, sodium bicarbonate, aluminum oxide and simethicone suspension on the in vitro availability of cefuroxime sodium. The mechanism of interaction between antibiotic and antacids was also studied.

  7. Energy levels and exchange interactions of spin clusters

    NASA Astrophysics Data System (ADS)

    Belorizky, E.

    1993-02-01

    We first describe a simple method for diagonalizing the isotropic exchange Hamiltonian of a cluster of N spins in the most general case where all the exchange constants are different. The technique, based on the rotation invariance of the system, leads to a considerable reduction of the total matrix. Simple expressions of the magnetization and susceptibility are provided and an example of the determination of the exchange constants of a complex with five Cu^{2+} ions is given. It is also shown that for a large variety of spin configurations occuring in metal complexes, it is possible to diagonalize the dominant isotropic exchange spin hamiltonian in a straightforward way by using recoupling techniques. This allows to solve problems up to a nine spin cluster with spins having different g values. This survey is pursued by the theoretical approach of the magnetic properties of interacting spins on a finite ring with a detailed study of an oligonuclear metal nitroxide complex formed by six Mn^{2+}(S = 5/2) and six free radicals (s = 1/2). The temperature behaviour of the susceptibility is interpreted with a semi-classical model of a cyclic alternate finite chain. Finally we give a procedure for determining the three exchange constants of three spin 1/2 coupled by isotropic exchange constants in the unsolved case where these constants are all dilferent. Nous décrivons d'abord une méthode simple pour diagonaliser l'Hamiltonien d'échange isotrope d'un cluster de N spins dans le cas le plus général où toutes les constantes d'échange sont différentes. La technique, basée sur l'invariance rotationnelle du système, conduit à une réduction considérable de la matrice totale. On donne des expressions simples de l'aimantation et de la susceptibilité et la méthode est appliquée à la détermination des interactions d'échange d'un complexe comprenant cinq ions Cu^{2+}. On montre également que pour une assez grande variété de configurations de spins pr

  8. Etude des Abondances de MG et de fe dans la Composante Stellaire des Disques des Galaxies Spirales

    NASA Astrophysics Data System (ADS)

    Beauchamp, Dominique

    Je presente ici une technique d'observation par imagerie des disques stellaires des galaxies spirales. Je tente, a l'aide d'un modele evolutif multiphase, de determiner les abondances de fer et de magnesium dans les disques. Dans ce but, je mesure les indices Mg2 et Fe5270 du systeme de Lick. Ces elements representent un choix judicieux d'indicateurs car ils sont formes par des supernovae de deux types differents ayant des durees de vie differentes. Le rapport d'abondances de ces deux elements est un indicateur du taux de formation des populations stellaires. Je decris, en premier lieu, les observations, la technique de mesure, ainsi que son application. J'analyse ensuite les indices mesures. A partir du modele multiphase, j'explore differents parametres physiques des spirales comme le taux de formation stellaire, l'evolution des abondances, les effets possibles de la presence de la barre, etc.

  9. Photons uniques indiscernables à partir d'une boîte quantique unique dans un cristal photonique

    NASA Astrophysics Data System (ADS)

    Laurent, S.; Varoutsis, S.; Le Gratiet, L.; Lemaître, A.; Sagnes, I.; Raineri, F.; Levenson, A.; Robert-Philip, I.; Abram, I.

    2006-10-01

    Nous avons développé et caractérisé une source de photons uniques basée sur l'émission spontanée d'une boîte quantique unique insérée dans une cavité à bande interdite photonique bidimensionnelle. Ce système nous a d'abord permis de produire des photons uniques, puis des photons uniques indiscernables avec une indiscernabilité supérieure à 70%. L'observation de l'indiscernabilité des photons, impossible sans un raccourcissement important de la durée de vie, met en évidence un effet Purcell supérieur à 25 dans ce système.

  10. Interactive Science on Mars

    NASA Astrophysics Data System (ADS)

    Mercer, C. R.; Landis, G. A.

    2017-02-01

    Swarms of small citizen-driven rovers can conduct Mars surface science missions. Transportation and communication technology needed for human exploration can enable this new interactive science mission architecture.

  11. Chasing Ecological Interactions.

    PubMed

    Jordano, Pedro

    2016-09-01

    Basic research on biodiversity has concentrated on individual species-naming new species, studying distribution patterns, and analyzing their evolutionary relationships. Yet biodiversity is more than a collection of individual species; it is the combination of biological entities and processes that support life on Earth. To understand biodiversity we must catalog it, but we must also assess the ways species interact with other species to provide functional support for the Tree of Life. Ecological interactions may be lost well before the species involved in those interactions go extinct; their ecological functions disappear even though they remain. Here, I address the challenges in studying the functional aspects of species interactions and how basic research is helping us address the fast-paced extinction of species due to human activities.

  12. Atomic & Molecular Interactions

    SciTech Connect

    2002-07-12

    The Gordon Research Conference (GRC) on Atomic & Molecular Interactions was held at Roger Williams University, Bristol, RI. Emphasis was placed on current unpublished research and discussion of the future target areas in this field.

  13. Interactive Office user's manual

    NASA Technical Reports Server (NTRS)

    Montgomery, Edward E.; Lowers, Benjamin; Nabors, Terri L.

    1990-01-01

    Given here is a user's manual for Interactive Office (IO), an executive office tool for organization and planning, written specifically for Macintosh. IO is a paperless management tool to automate a related group of individuals into one productive system.

  14. Chasing Ecological Interactions

    PubMed Central

    2016-01-01

    Basic research on biodiversity has concentrated on individual species—naming new species, studying distribution patterns, and analyzing their evolutionary relationships. Yet biodiversity is more than a collection of individual species; it is the combination of biological entities and processes that support life on Earth. To understand biodiversity we must catalog it, but we must also assess the ways species interact with other species to provide functional support for the Tree of Life. Ecological interactions may be lost well before the species involved in those interactions go extinct; their ecological functions disappear even though they remain. Here, I address the challenges in studying the functional aspects of species interactions and how basic research is helping us address the fast-paced extinction of species due to human activities. PMID:27631692

  15. Interactive Design Activism

    NASA Astrophysics Data System (ADS)

    Goulev, Petar; Farrer, Joan

    The following sections are included: * Introduction * Computers and Human Well-being * To Fuzzy or Yes (No)! * Interactive Design Activism * Sensing the Sun * Personalised Public Health Advice * Modifying Human Behaviour * Transdisciplinarity, Knowledge Transfer and Multi-domain

  16. Towards interactive narrative medicine.

    PubMed

    Cavazza, Marc; Charles, Fred

    2013-01-01

    Interactive Storytelling technologies have attracted significant interest in the field of simulation and serious gaming for their potential to provide a principled approach to improve user engagement in training scenarios. In this paper, we explore the use of Interactive Storytelling to support Narrative Medicine as a reflective practice. We describe a workflow for the generation of virtual narratives from high-level descriptions of patients' experiences as perceived by physicians, which can help to objectivize such perceptions and support various forms of analysis.

  17. Vortice-propeller interaction

    NASA Astrophysics Data System (ADS)

    Hemon, Alain; Huberson, Serge

    1989-08-01

    The interactions between a ship's propeller blades and the boundary layer created by the ship are investigated. A finite element calculation method based on Navier-Stokes equation is developed. The application of an k-epsilon turbulence model for improving the analysis is considered. The flow azimuthal homogenization hypothesis is applied and leads to an accurate evaluation of the propeller performances. The unsteady effects generated by the interaction between the propeller blades and the vortices are analyzed.

  18. Replicators with Hebb interactions

    NASA Astrophysics Data System (ADS)

    de Oliveira, V. M.

    2003-01-01

    We do an analytical study of the statistical properties of an ecosystem composed of species that are coupled via pairwise interactions that are given by the Hebb rule and have deterministic self-interactions u. In the model each species is characterized by an infinite set of p = αN traits. As one of our main results, we observe that the ecosystem becomes less cooperative as the complexity of species (number of traits) is increased.

  19. Grapefruit and drug interactions.

    PubMed

    2012-12-01

    Since the late 1980s, grapefruit juice has been known to affect the metabolism of certain drugs. Several serious adverse effects involving drug interactions with grapefruit juice have been published in detail. The components of grapefruit juice vary considerably depending on the variety, maturity and origin of the fruit, local climatic conditions, and the manufacturing process. No single component accounts for all observed interactions. Other grapefruit products are also occasionally implicated, including preserves, lyophylised grapefruit juice, powdered whole grapefruit, grapefruit seed extract, and zest. Clinical reports of drug interactions with grapefruit juice are supported by pharmacokinetic studies, each usually involving about 10 healthy volunteers, in which the probable clinical consequences were extrapolated from the observed plasma concentrations. Grapefruit juice inhibits CYP3A4, the cytochrome P450 isoenzyme most often involved in drug metabolism. This increases plasma concentrations of the drugs concerned, creating a risk of overdose and dose-dependent adverse effects. Grapefruit juice also inhibits several other cytochrome P450 isoenzymes, but they are less frequently implicated in interactions with clinical consequences. Drugs interacting with grapefruit and inducing serious clinical consequences (confirmed or very probable) include: immunosuppressants, some statins, benzodiazepines, most calcium channel blockers, indinavir and carbamazepine. There are large inter-individual differences in enzyme efficiency. Along with the variable composition of grapefruit juice, this makes it difficult to predict the magnitude and clinical consequences of drug interactions with grapefruit juice in a given patient. There is increasing evidence that transporter proteins such as organic anion transporters and P-glycoprotein are involved in interactions between drugs and grapefruit juice. In practice, numerous drugs interact with grapefruit juice. Although only a few

  20. PIA: ISOPHOT Interactive Analysis

    NASA Astrophysics Data System (ADS)

    Gabriel, Carlos; Acosta, Jose; Heinrichsen, Ingolf; Skaley, Detlef; Tai, Wai Ming; Morris, Huw; Merluzzi, Paola

    2014-08-01

    ISOPHOT is one of the instruments on board the Infrared Space Observatory (ISO). ISOPHOT Interactive Analysis (PIA) is a scientific and calibration interactive data analysis tool for ISOPHOT data reduction. Written in IDL under Xwindows, PIA offers a full context sensitive graphical interface for retrieving, accessing and analyzing ISOPHOT data. It is available in two nearly identical versions; a general observers version omits the calibration sequences.

  1. Food-drug interactions.

    PubMed

    Schmidt, Lars E; Dalhoff, Kim

    2002-01-01

    Interactions between food and drugs may inadvertently reduce or increase the drug effect. The majority of clinically relevant food-drug interactions are caused by food-induced changes in the bioavailability of the drug. Since the bioavailability and clinical effect of most drugs are correlated, the bioavailability is an important pharmacokinetic effect parameter. However, in order to evaluate the clinical relevance of a food-drug interaction, the impact of food intake on the clinical effect of the drug has to be quantified as well. As a result of quality review in healthcare systems, healthcare providers are increasingly required to develop methods for identifying and preventing adverse food-drug interactions. In this review of original literature, we have tried to provide both pharmacokinetic and clinical effect parameters of clinically relevant food-drug interactions. The most important interactions are those associated with a high risk of treatment failure arising from a significantly reduced bioavailability in the fed state. Such interactions are frequently caused by chelation with components in food (as occurs with alendronic acid, clodronic acid, didanosine, etidronic acid, penicillamine and tetracycline) or dairy products (ciprofloxacin and norfloxacin), or by other direct interactions between the drug and certain food components (avitriptan, indinavir, itraconazole solution, levodopa, melphalan, mercaptopurine and perindopril). In addition, the physiological response to food intake, in particular gastric acid secretion, may reduce the bioavailability of certain drugs (ampicillin, azithromycin capsules, didanosine, erythromycin stearate or enteric coated, and isoniazid). For other drugs, concomitant food intake may result in an increase in drug bioavailability either because of a food-induced increase in drug solubility (albendazole, atovaquone, griseofulvin, isotretinoin, lovastatin, mefloquine, saquinavir and tacrolimus) or because of the secretion of

  2. Beam-Material Interaction

    SciTech Connect

    Mokhov, N. V.; Cerutti, F.

    2016-01-01

    Th is paper is motivated by the growing importance of better understanding of the phenomena and consequences of high-intensity energetic particle beam interactions with accelerator, generic target, and detector components. It reviews the principal physical processes of fast-particle interactions with matter, effects in materials under irradiation, materials response, related to component lifetime and performance, simulation techniques, and methods of mitigating the impact of radiation on the components and environment in challenging current and future applications.

  3. Human-machine interactions

    DOEpatents

    Forsythe, J. Chris; Xavier, Patrick G.; Abbott, Robert G.; Brannon, Nathan G.; Bernard, Michael L.; Speed, Ann E.

    2009-04-28

    Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

  4. Interactive DIF Generator

    NASA Technical Reports Server (NTRS)

    Preheim, Larry E.; Amy, Laraine; Young, Jimmie D.

    1993-01-01

    Interactive DIF Generator (IDG) computer program serves as utility to generate and manipulate directory interchange format (DIF) files. Creates and updates DIF files, sent to NASA's Master Directory, also referred to as International Global Change Directory at Goddard Space Flight Center. Many government and university data systems use Master Directory to advertise availability of research data. IDG is interactive software tool and requires mouse or trackball to operate. Written in C language.

  5. Flank solar wind interaction

    NASA Technical Reports Server (NTRS)

    Moses, Stewart L.; Greenstadt, Eugene W.; Coroniti, Ferdinand V.

    1994-01-01

    In this report we will summarize the results of the work performed under the 'Flank Solar Wind Interaction' investigation in support of NASA's Space Physics Guest Investigator Program. While this investigation was focused on the interaction of the Earth's magnetosphere with the solar wind as observed by instruments on the International Sun-Earth Explorer (ISEE) 3 spacecraft, it also represents the culmination of decades of research performed by scientists at TRW on the rich phenomenology of collisionless shocks in space.

  6. Interaction with Machine Improvisation

    NASA Astrophysics Data System (ADS)

    Assayag, Gerard; Bloch, George; Cont, Arshia; Dubnov, Shlomo

    We describe two multi-agent architectures for an improvisation oriented musician-machine interaction systems that learn in real time from human performers. The improvisation kernel is based on sequence modeling and statistical learning. We present two frameworks of interaction with this kernel. In the first, the stylistic interaction is guided by a human operator in front of an interactive computer environment. In the second framework, the stylistic interaction is delegated to machine intelligence and therefore, knowledge propagation and decision are taken care of by the computer alone. The first framework involves a hybrid architecture using two popular composition/performance environments, Max and OpenMusic, that are put to work and communicate together, each one handling the process at a different time/memory scale. The second framework shares the same representational schemes with the first but uses an Active Learning architecture based on collaborative, competitive and memory-based learning to handle stylistic interactions. Both systems are capable of processing real-time audio/video as well as MIDI. After discussing the general cognitive background of improvisation practices, the statistical modelling tools and the concurrent agent architecture are presented. Then, an Active Learning scheme is described and considered in terms of using different improvisation regimes for improvisation planning. Finally, we provide more details about the different system implementations and describe several performances with the system.

  7. Sperm-egg interaction.

    PubMed

    Evans, Janice P

    2012-01-01

    A crucial step of fertilization is the sperm-egg interaction that allows the two gametes to fuse and create the zygote. In the mouse, CD9 on the egg and IZUMO1 on the sperm stand out as critical players, as Cd9(-/-) and Izumo1(-/-) mice are healthy but infertile or severely subfertile due to defective sperm-egg interaction. Moreover, work on several nonmammalian organisms has identified some of the most intriguing candidates implicated in sperm-egg interaction. Understanding of gamete membrane interactions is advancing through characterization of in vivo and in vitro fertilization phenotypes, including insights from less robust phenotypes that highlight potential supporting (albeit not absolutely essential) players. An emerging theme is that there are varied roles for gamete molecules that participate in sperm-egg interactions. Such roles include not only functioning as fusogens, or as adhesion molecules for the opposite gamete, but also functioning through interactions in cis with other proteins to regulate membrane order and functionality.

  8. Analyse numerique de la microplasticite aux joints de grains dans les polycristaux metalliques CFC

    NASA Astrophysics Data System (ADS)

    Andriamisandratra, Mamiandrianina

    La rupture par fatigue concerne aujourd’hui encore beaucoup de pièces métalliques soumises en service à un chargement répétitif. À l’échelle de la microstructure, les joints de grains sont connus pour jouer un rôle important dans la tenue en fatigue du matériau grâce au durcissement qu’ils confèrent. Cependant les joints de grains eux-mêmes ou la zone à leur proximité ont souvent été identifiés comme lieux d’amorçage de fissures de fatigue, particulièrement dans le cas des métaux cubiques à faces centrées (CFC). Dans le but de caractériser le comportement micromécanique à proximité de différents types de joint de grain, le comportement à l’interface en traction monotone uniaxiale a été modélisé par la méthode des éléments finis et une loi de plasticité cristalline a été utilisée. De plus, quelques configurations cristallographiques bicristallines ont alors été simulées et leur comportement a été analysé sous un chargement de traction axiale monotone. Le cadre de validité de la modélisation a été restreint à celui des petites déformations (<5%). Quatre critères importants dictant le comportement mécanique cristallin ont été identifiés. Il s’agit de la rigidité élastique, du facteur de Schmid des deux systèmes de glissement les plus favorables, et enfin du ratio entre ces deux plus forts facteurs de Schmid traduisant la propension au glissement simple ou multiple. Des simulations de traction sur des monocristaux ont ainsi permis de comprendre l’influence propre de chaque critère sur le comportement macroscopique (contraintes et déformations) et microscopique (glissements cristallins). Les calculs bicristallins ont ensuite mis en évidence l’activation particulière de certains systèmes de glissement à priori non favorables au niveau du joint de grain. Ce phénomène a été associé avec la nécessité d’assurer la compatibilité mécanique de déformation de part et d’autre de l

  9. Deploiement et gestion d'un reseau de noeuds multimedias embarques et distribues dans un habitat intelligent

    NASA Astrophysics Data System (ADS)

    Stein, Kilian

    Les laboratoires de recherche sur l'assistance aux personnes âgées ou avec une déficience cognitive possèdent actuellement peu de solutions réellement déployables dans un habitat. Ils se heurtent donc à un problème de transfert de leurs applications vers des conditions réelles. En effet, la plupart de ces applications ont besoin de serveurs et d'équipements coûteux ou complexes à installer. La nouvelle tendance des laboratoires de recherche est donc à l'élaboration de solutions plug and play. En effet, ces dernières sont facilement et rapidement installables dans un habitat. C'est dans cette optique que mon présent projet de recherche a été réalisé. L'objectif de cette maîtrise est de proposer une solution à ce problème en déployant des plateformes embarquées pouvant supporter des applications multimédias distribuées. Ces plateformes appelées noeuds multimédias ont la particularité d'être simples d'installation, peu intrusives et de faibles coûts. Afin de tester la gestion du réseau de noeuds multimédias, une application distribuée de suivi multimédia à travers un habitat intelligent a été réalisée dans l'appartement du laboratoire DOMUS. Mots-clés : réseau, distribué, multimédia, embarqué, habitat intelligent, déploiement, gestion, suivi multimédia.

  10. Étude du bruit quantique dans les microlasers à semi-conducteurs à cavité verticale (VCSELs)

    NASA Astrophysics Data System (ADS)

    Maurin, I.; Hermier, J.-P.; Bramati, A.; Ducci, S.; Giacobino, E.; Kolobov, M.; Zelaquett Khoury, A.

    2002-06-01

    Nous étudions le bruit quantique dans les microlasers semi-conducteurs à cavité verticale. Ils émettent des faisceaux avec plusieurs modes transverses de polarisations variées. Lorsqu'un seul mode transverse, polarisé linéairement oscille, nous démontrons théoriquement et expérimentalement l'importance de l'émission dans la direction de polarisation orthogonale pour la caractérisation du bruit d'intensité. En régime multimode transverse, les anticorrélations sont importantes entre modes transverses, certains échantillons produisent des faisceaux au bruit d'intensité comprimé. Pour les échantillons présentant un excès de bruit, l'injection optique permet d'obtenir un bruit comprimé. Nous étudions également la structure spatiale du bruit d'intensité dans le plan transverse.

  11. Impact de la preparation des anodes crues et des conditions de cuisson sur la fissuration dans des anodes denses

    NASA Astrophysics Data System (ADS)

    Amrani, Salah

    La fabrication de l'aluminium est realisee dans une cellule d'electrolyse, et cette operation utilise des anodes en carbone. L'evaluation de la qualite de ces anodes reste indispensable avant leur utilisation. La presence des fissures dans les anodes provoque une perturbation du procede l'electrolyse et une diminution de sa performance. Ce projet a ete entrepris pour determiner l'impact des differents parametres de procedes de fabrication des anodes sur la fissuration des anodes denses. Ces parametres incluent ceux de la fabrication des anodes crues, des proprietes des matieres premieres et de la cuisson. Une recherche bibliographique a ete effectuee sur tous les aspects de la fissuration des anodes en carbone pour compiler les travaux anterieurs. Une methodologie detaillee a ete mise au point pour faciliter le deroulement des travaux et atteindre les objectifs vises. La majorite de ce document est reservee pour la discussion des resultats obtenus au laboratoire de l'UQAC et au niveau industriel. Concernant les etudes realisees a l'UQAC, une partie des travaux experimentaux est reservee a la recherche des differents mecanismes de fissuration dans les anodes denses utilisees dans l'industrie d'aluminium. L'approche etait d'abord basee sur la caracterisation qualitative du mecanisme de la fissuration en surface et en profondeur. Puis, une caracterisation quantitative a ete realisee pour la determination de la distribution de la largeur de la fissure sur toute sa longueur, ainsi que le pourcentage de sa surface par rapport a la surface totale de l'echantillon. Cette etude a ete realisee par le biais de la technique d'analyse d'image utilisee pour caracteriser la fissuration d'un echantillon d'anode cuite. L'analyse surfacique et en profondeur de cet echantillon a permis de voir clairement la formation des fissures sur une grande partie de la surface analysee. L'autre partie des travaux est basee sur la caracterisation des defauts dans des echantillons d'anodes crues

  12. Numerical simulations of Rock Avalanches with DAN-3D: from real case to analogue models

    NASA Astrophysics Data System (ADS)

    Longchamp, Céline; Penna, Ivanna; Sauthier, Claire; Jaboyedoff, Michel

    2013-04-01

    Rock avalanches are rapid events with capacity to develop long and unexpected runouts, which can evolve into catastrophic events difficult to predict. In order to better understand unusual travel distances, analogue and numerical modeling are often used. The comparison between real case, and analogue and dynamics models is key to constrain and understand parameters governing rock avalanches run outs. In the Pampeanas range (Argentina), the Potrero de Leyes rock avalanche involved 0.23 km3 of highly fractured metamorphic rocks that spread in the piedmont area without any topographical constrain, resulting in a runout of 4.8 km. In this study we first attempt to apply analogue models to replicate the rock avalanche deposit. The analogue modeling consists into the release of a granular material (calibrated and angular carborundum sand) along a slope, creating similar landscape conditions that the real case. The material is not constrained laterally and spread freely on a flat deposition surface. For a volume of 50 cm3, the runout is 50 cm, the deposit has as length of 10 cm and a width of 19 cm. For a volume of 100 cm3, the runout is 65 cm, the deposit has as length of 25 cm and a width of 30 cm. In a further step we model both the real case and the result of the analogue models. Dynamics models are carried out with DAN-3D, a dynamic model for the prediction of the run out of rapid landslide (O. Hungr, 1995; O. Hugr & S.G. Evans, 1996). The result of the simulations for both volumes tested with the analogue model give satisfactory results. In fact, for the volume of 50 cm3, the deposit has as length of 10 cm and a width of 20 cm and for the volume of 100 cm3, the deposit has as length of 25 cm and a width of 50 cm. The shape and the thickness of the deposit obtained with DAN-3D are also similar with those got with the analogue models.

  13. Lake evolution during the Early Danian Dan-C2 hyperthermal, Boltysh impact crater, Ukraine

    NASA Astrophysics Data System (ADS)

    Ebinghaus, Alena; Jolley, David W.

    2016-04-01

    Lacustrine facies record complex relationships between lake evolution and environmental conditions and provide proxies for climate changes. However, lacustrine successions formed during past hyperthermals as recorded from negative carbon isotope excursions (CIEs) are of limited availability and thus less well understood. Here, we present a complete lacustrine record of the Early Danian Dan-C2 hyperthermal at c. 65.2 Ma from a core drilled in the K-Pg Boltysh impact crater, Ukraine. This borehole allows a detailed facies analysis and reconstruction of lake evolution and associated plant ecosystem in correspondence with rapid climate change. The Boltysh borehole reveals a c. 400 m thick siliciclastic and organic-rich succession overlying impact melt-breccia dated at 65.17 ± 0.64 Ma. Based on detailed core logging, 8 distinctive facies associations are identified, including 1) littoral mudstones, 2) siliciclastic shoreline deposits, 3) siliciclastic littoral to sublittoral deposits, 4) mudstone laminites, 5) organic-rich mudstones, and deposits of 6) coarse-grained, 7) fine-grained density currents, and 8) debris flows. Based on the occurrence of these facies associations 3 major phases of lake evolution are distinguished: 1) an initial pre-CIE rising clastic-dominated lake phase characterised by the presence of coarse-grained density and debris flow deposits, 2) an organic-rich fluctuating shallow lake phase during the main phase of the CIE, characterised by alternating packages of the mudstone laminites and organic-rich mudstones; and 3) a rising clastic-dominated lake during and post-CIE recovery phase, which shows a high presence of siliciclastic shoreline and littoral to sublittoral deposits. This study provides a full record of lacustrine response to climate change during the Dan-C2 hyperthermal, and subsequently allows us to infer lake formation and environmental conditions at different stages during climate warming. The high resolution sedimentary record

  14. L'observance thérapeutique dans les dermatoses chroniques: à propos de 200 cas

    PubMed Central

    Amraoui, Nissrine; Gallouj, Salim; Berraho, Mohamed Amine; Najjari, Chakib; Mernissi, Fatima zohra

    2015-01-01

    Introduction L'observance thérapeutique est la capacité à prendre correctement son traitement, tel qu'il est prescrit par le médecin. Elle est peu étudiée en dermatologie. Méthodes Le but de notre étude est d’évaluer l'observance chez les patients suivis au service de dermatologie du Centre Hospitalier Universitaire Hassan II de Fès pour une dermatose chronique et de rechercher les facteurs liés à une mauvaise observance à travers une étude incluant 200 patients suivis depuis au moins 6 mois. L’évaluation de l'observance s'est faite essentiellement à l'aide d'un entretien et les facteurs liés à l'observance ont été recherchés par un questionnaire. Résultats 68% de nos patients étaient observant, la mauvaise observance était associée à un niveau socio économique et d’étude bas, à une vie solitaire, à une durée de suivi longue, aux effets secondaires et au coût élevé des traitements, à l'absence d'efficacité, à une faible visibilité des lésions, à une ordonnance complexe, à une explication faible de la maladie, et à des difficultés d'accès à la consultation. Le taux d'observance retrouvé dans notre étude est un taux satisfaisant selon les données de la littérature, notre étude a confirmée certaines facteurs connues et a mis le point sur d'autres facteurs peu étudiés tel un traitement traditionnel associé, la part de chaque forme de traitement dans le respect de l'ordonnance, les dermatoses les plus touchées par les difficulté d'observance a savoir les dermatoses bulleuses et le psoriasis, et l'intérêt du pharmacien. Conclusion Cette analyse de la fréquence de ce phénomène et des facteurs essentiels qui l'influencent permet de cibler la prise en charge à travers une personnalisation de l'entretien médical, une adaptation du suivi au contexte de nos patients et à la nature de notre institution de santé. PMID:26848363

  15. The Boltysh crater record of rapid vegetation change during the Dan-C2 hyperthermal event.

    NASA Astrophysics Data System (ADS)

    Jolley, D. W.; Daly, R.; Gilmour, I.; Gilmour, M.; Kelley, S. P.

    2012-04-01

    Analysis of a cored borehole drilled through the sedimentary fill of the 24km wide Boltysh meteorite crater, Ukraine has yielded a unique, high resolution record spanning <1my of Early Paleocene terrestrial environmental change. While the oldest crater fill sediments preserve a record of the K/Pg boundary, overlying sediments preserve a record through the earliest Danian Dan-C2 hyperthermal event. This event is preserved in ~220m of lacustrine organic mudrocks and shows close similarities to the carbon isotope records of the Toarcian and PETM CIE's. At Boltysh, the rapid sedimentation rate and lack of bioturbation in the crater fill lacustrine deposits preserve uniquely high resolution pollen, spore and algae records. These records reflect environmental change from the K/Pg1 to the post Dan-C2 Danian. Leading into the CIE, warm temperate gymnosperm - angiosperm - fern communities are replaced by precipitation limited (winterwet) plant communities within the negative CIE. Winterwet plant communities dominate the negative CIE, but are replaced within the isotope recovery stage by warm temperate floras. These in turn give way to cooler temperate floras in the post positive CIE section of the uppermost crater fill. The distribution of temperate taxa about the negative CIE represents the broadest scale of oscillatory variation in the palynofloras. Shorter frequency oscillations are evident from diversity and botanical group distributions reflecting changes in moisture availability over several thousand years. Detailed analysis of variability within one of these oscillations records plant community cyclicity across the inception of the negative CIE. This short term cyclicity provides evidence that the replacement of warm termperate by winterwet floras occurred in a stepwise manner at the negative CIE suggesting cumulative atmospheric forcing. At <1mm scale, lamination within the negative CIE showed no obvious lithological or colour differences, and are not seasonal

  16. Hydrogen and chlorine abundances in the Kimberley formation of Gale crater measured by the DAN instrument on board the Mars Science Laboratory Curiosity rover

    NASA Astrophysics Data System (ADS)

    Litvak, M. L.; Mitrofanov, I. G.; Hardgrove, C.; Stack, K. M.; Sanin, A. B.; Lisov, D.; Boynton, W. V.; Fedosov, F.; Golovin, D.; Harshman, K.; Jun, I.; Kozyrev, A. S.; Kuzmin, R. O.; Malakhov, A.; Milliken, R.; Mischna, M.; Moersch, J.; Mokrousov, M.; Nikiforov, S.; Starr, R.; Tate, C.; Tret'yakov, V. I.; Vostrukhin, A.

    2016-05-01

    The Dynamic Albedo of Neutron (DAN) instrument on board the Mars Science Laboratory Curiosity rover acquired a series of measurements as part of an observational campaign of the Kimberley area in Gale crater. These observations were planned to assess the variability of bulk hydrogen and neutron-absorbing elements, characterized as chlorine-equivalent concentration, in the geologic members of the Kimberley formation and in surface materials exposed throughout the area. During the traverse of the Kimberley area, Curiosity drove primarily over the "Smooth Hummocky" unit, a unit composed primarily of sand and loose rocks, with occasional stops at bedrock of the Kimberley formation. During the Kimberley campaign, DAN detected ranges of water equivalent hydrogen (WEH) and chlorine-equivalent concentrations of 1.5-2.5 wt % and 0.6-2 wt %, respectively. Results show that as the traverse progressed, DAN observed an overall decrease in both WEH and chlorine-equivalent concentration measured over the sand and loose rocks of the Smooth Hummocky unit. DAN measurements of WEH and chlorine-equivalent concentrations in the well-exposed sedimentary bedrock of the Kimberley formation show fluctuations with stratigraphic position. The Kimberley campaign also provided an opportunity to compare measurements from DAN with those from the Sample Analysis at Mars (SAM) and the Alpha-Particle X-ray Spectrometer (APXS) instruments. DAN measurements obtained near the Windjana drill location show a WEH concentration of ~1.5 wt %, consistent with the concentration of low-temperature absorbed water measured by SAM for the Windjana drill sample. A comparison between DAN chlorine-equivalent concentrations measured throughout the Kimberley area and APXS observations of corresponding local surface targets and drill fines shows general agreement between the two instruments.

  17. Developpement de mesures non destructives, par ondes ultrasonores, d'epaisseurs de fronts de solidification dans les reacteurs metallurgiques

    NASA Astrophysics Data System (ADS)

    Floquet, Jimmy

    Dans les cuves d'electrolyse d'aluminium, le milieu de reaction tres corrosif attaque les parois de la cuve, ce qui diminue leur duree de vie et augmente les couts de production. Le talus, qui se forme sous l'effet des pertes de chaleur qui maintiennent un equilibre thermique dans la cuve, sert de protection naturelle a la cuve. Son epaisseur doit etre controlee pour maximiser cet effet. Advenant la resorption non voulue de ce talus, les degats generes peuvent s'evaluer a plusieurs centaines de milliers de dollars par cuve. Aussi, l'objectif est de developper une mesure ultrasonore de l'epaisseur du talus, car elle serait non intrusive et non destructive. La precision attendue est de l'ordre du centimetre pour des mesures d'epaisseurs comprenant 2 materiaux, allant de 5 a 20 cm. Cette precision est le facteur cle permettant aux industriels de controler l'epaisseur du talus de maniere efficace (maximiser la protection des parois tout en maximisant l'efficacite energetique du procede), par l'ajout d'un flux thermique. Cependant, l'efficacite d'une mesure ultrasonore dans cet environnement hostile reste a demontrer. Les travaux preliminaires ont permis de selectionner un transducteur ultrasonore a contact ayant la capacite a resister aux conditions de mesure (hautes temperatures, materiaux non caracterises...). Differentes mesures a froid (traite par analyse temps-frequence) ont permis d'evaluer la vitesse de propagation des ondes dans le materiau de la cuve en graphite et de la cryolite, demontrant la possibilite d'extraire l'information pertinente d'epaisseur du talus in fine. Fort de cette phase de caracterisation des materiaux sur la reponse acoustique des materiaux, les travaux a venir ont ete realises sur un modele reduit de la cuve. Le montage experimental, un four evoluant a 1050 °C, instrumente d'une multitude de capteurs thermique, permettra une comparaison de la mesure intrusive LVDT a celle du transducteur, dans des conditions proches de la mesure

  18. The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish.

    PubMed

    Hashimoto, Hisashi; Rebagliati, Michael; Ahmad, Nadira; Muraoka, Osamu; Kurokawa, Tadahide; Hibi, Masahiko; Suzuki, Tohru

    2004-04-01

    We have isolated a novel gene, charon, that encodes a member of the Cerberus/Dan family of secreted factors. In zebrafish, Fugu and flounder, charon is expressed in regions embracing Kupffer's vesicle, which is considered to be the teleost fish equivalent to the region of the mouse definitive node that is required for left-right (L/R) patterning. Misexpression of Charon elicited phenotypes similar to those of mutant embryos defective in Nodal signaling or embryos overexpressing Antivin(Atv)/Lefty1, an inhibitor for Nodal and Activin. Charon also suppressed the dorsalizing activity of all three of the known zebrafish Nodal-related proteins (Cyclops, Squint and Southpaw), indicating that Charon can antagonize Nodal signaling. Because Southpaw functions in the L/R patterning of lateral plate mesoderm and the diencephalon, we asked whether Charon is involved in regulating L/R asymmetry. Inhibition of Charon's function by antisense morpholino oligonucleotides (MOs) led to a loss of L/R polarity, as evidenced by bilateral expression of the left side-specific genes in the lateral plate mesoderm (southpaw, cyclops, atv/lefty1, lefty2 and pitx2) and diencephalon (cyclops, atv/lefty1 and pitx2), and defects in early (heart jogging) and late (heart looping) asymmetric heart development, but did not disturb the notochord development or the atv/lefty1-mediated midline barrier function. MO-mediated inhibition of both Charon and Southpaw led to a reduction in or loss of the expression of the left side-specific genes, suggesting that Southpaw is epistatic to Charon in left-side formation. These data indicate that antagonistic interactions between Charon and Nodal (Southpaw), which take place in regions adjacent to Kupffer's vesicle, play an important role in L/R patterning in zebrafish.

  19. Dike/Drift Interactions

    SciTech Connect

    E. Gaffiney

    2004-11-23

    This report presents and documents the model components and analyses that represent potential processes associated with propagation of a magma-filled crack (dike) migrating upward toward the surface, intersection of the dike with repository drifts, flow of magma in the drifts, and post-magma emplacement effects on repository performance. The processes that describe upward migration of a dike and magma flow down the drift are referred to as the dike intrusion submodel. The post-magma emplacement processes are referred to as the post-intrusion submodel. Collectively, these submodels are referred to as a conceptual model for dike/drift interaction. The model components and analyses of the dike/drift interaction conceptual model provide the technical basis for assessing the potential impacts of an igneous intrusion on repository performance, including those features, events, and processes (FEPs) related to dike/drift interaction (Section 6.1).

  20. Achromatic Interaction Point Design

    SciTech Connect

    Guimei Wang,, Yaroslav Derbenev, S.Alex Bogacz, P. Chevtsov, Andre Afanaciev, Charles Ankenbrandt, Valentin Ivanov, Rolland P. Johnson

    2009-05-01

    Designers of high-luminosity energy-frontier muon colliders must provide strong beam focusing in the interaction regions. However, the construction of a strong, aberration-free beam focus is difficult and space consuming, and long straight sections generate an off-site radiation problem due to muon decay neutrinos that interact as they leave the surface of the earth. Without some way to mitigate the neutrino radiation problem, the maximum c.m. energy of a muon collider will be limited to about 3.5 TeV. A new concept for achromatic low beta design is being developed, in which the interaction region telescope and optical correction elements, are installed in the bending arcs. The concept, formulated analytically, combines space economy, a preventative approach to compensation for aberrations, and a reduction of neutrino flux concentration. An analytical theory for the aberration-free, low beta, spatially compact insertion is being developed.

  1. Interactions of anabolic steroids.

    PubMed

    Kopera, H

    1993-01-01

    Drug-drug interactions, or interference between drugs and other treatments, depend on many factors and are therefore difficult to predict. However, a number are clearly established in the case of anabolic-androgenic steroids. The beneficial interactions between anabolic steroids and radiotherapy or cytostatic drugs respectively are of therapeutic value. Adjuvant treatment with anabolic compounds in patients undergoing radiation and/or cytostatic therapy is beneficial because it can prevent or reduce depression of erythropoiesis, granulopoiesis and thrombopoiesis. It also diminishes protein catabolism, supports recovery, improves the general condition of the patient and minimizes radiation sickness. Potentially adverse interactions with anabolic steroids must be expected in the case of oral anticoagulants and antidiabetic drugs, since sensitivity to each of the latter is increased. This makes it particularly advisable to monitor patients receiving either oral anticoagulants or antidiabetic treatment concurrently with anabolic drugs.

  2. History of Weak Interactions

    DOE R&D Accomplishments Database

    Lee, T. D.

    1970-07-01

    While the phenomenon of beta-decay was discovered near the end of the last century, the notion that the weak interaction forms a separate field of physical forces evolved rather gradually. This became clear only after the experimental discoveries of other weak reactions such as muon-decay, muon-capture, etc., and the theoretical observation that all these reactions can be described by approximately the same coupling constant, thus giving rise to the notion of a universal weak interaction. Only then did one slowly recognize that the weak interaction force forms an independent field, perhaps on the same footing as the gravitational force, the electromagnetic force, and the strong nuclear and sub-nuclear forces.

  3. Propeller/wing interaction

    NASA Technical Reports Server (NTRS)

    Witkowski, David P.; Johnston, Robert T.; Sullivan, John P.

    1989-01-01

    The present experimental investigation of the steady-state and unsteady-state effects due to the interaction between a tractor propeller's wake and a wing employs, in the steady case, wind tunnel measurements at low subsonic speed; results are obtained which demonstrate wing performance response to variations in configuration geometry. Other steady-state results involve the propeller-hub lift and side-force due to the wing's influence on the propeller. The unsteady effects of interaction were studied through flow visualization of propeller-tip vortex distortion over a wing, again using a tractor-propeller configuration.

  4. Solar-terrestrial interactions

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The effects of solar radiation on man's environment are discussed. It is solar radiation that is the basic energy source driving the circulations of the earth's atmosphere and oceans. Solar radiation is responsible for the ionization of the earth's upper atmosphere to form the ionosphere, which is important to our understanding of the magnetosphere and its interaction with the solar wind. The solar wind, which is the continuous (but not steady) flow of the sun's coronal plasma and magnetic field into interplanetary space, plays both an active and passive role in its interaction with the earth's environment.

  5. The new interactive CESAR

    SciTech Connect

    Fox, P.B.; Yatabe, M.

    1987-01-01

    In this report the Nuclear Criticality Safety Analytical Methods Resource Center describes a new interactive version of CESAR, a critical experiments storage and retrieval program available on the Nuclear Criticality Information System (NCIS) database at Lawrence Livermore National Laboratory. The original version of CESAR did not include interactive search capabilities. The CESAR database was developed to provide a convenient, readily accessible means of storing and retrieving code input data for the SCALE Criticality Safety Analytical Sequences and the codes comprising those sequences. The database includes data for both cross section preparation and criticality safety calculations. 3 refs., 1 tab.

  6. Optimisation des transferts de chaleur dans un systeme de stockage d'hydrogene a base d'alanate de sodium

    NASA Astrophysics Data System (ADS)

    Bhouri, Maha

    Le déploiement des applications de transport basées sur l'hydrogène comme source d'énergie est assujetti à l'identification d'une méthode efficace pour son stockage. En ce qui concerne la voie de stockage solide, les principaux inconvénients sont les faibles propriétés thermiques de l'hydrure, le long temps de chargement du réservoir et sa faible capacité gravimétrique. Dans ce cadre, l'alanate de sodium est choisi comme matériau de référence pour optimiser le fonctionnement d'un système de stockage d'un kilogramme d'hydrogène, en termes d'efficacité thermique et de capacités gravimétrique et volumétrique. Trois configurations ont été considérées en variant la disposition du lit d'hydrure et du fluide de refroidissement ainsi que le choix des échangeurs de chaleur et des structures permettant l'amélioration des propriétés thermiques de ce lit. Le modèle mathématique décrivant les transferts de chaleur et de masse au sein du lit d'hydrure a été résolu avec le logiciel commercial COMSOL Multiphysics® 3.5a. Les résultats numériques nous ont permis de déterminer l'interaction entre les propriétés géométriques des éléments d'échange de chaleur et le taux de stockage d'hydrogène ainsi que sa dépendance des conditions opérationnelles. L'efficacité thermique du système de stockage est déterminée en comparant le taux de stockage d'hydrogène calculé à celui issu du modèle de cinétique et validé avec les données expérimentales. Une fois que la quantité d'hydrogène stocké est optimisée, la contribution des éléments d'échange de chaleur au poids et au volume du réservoir et les capacités gravimétrique et volumétrique des configurations correspondantes sont déterminées et discutées en fonction des critères de sélection fixées par le DOE.

  7. Apport de la biopsie radioguidée dans le diagnostic histopathologique des tumeurs de l'enfant: expérience de l'Hôpital d'Enfant de Rabat

    PubMed Central

    El Ochi, Mohamed Réda; Bellarbi, Salma; Rouas, Lamiae; Lamalmi, Najat; Malihy, Abderrahmane; Alhamany, Zaitouna; Cherradi, Nadia

    2015-01-01

    La biopsie radioguidée constitue une alternative à la biopsie chirurgicale invasive et à la cytologie pour le diagnostic des tumeurs pédiatriques. L'intérêt de notre étude est d’évaluer la valeur diagnostique des biopsies radioguidées examinées au laboratoire d'anatomopathologie de l'hôpital d'Enfants de Rabat (HER). L’étude a porté sur 78 biopsies radioguidées recueillies dans notre laboratoire entre janvier 2008 et décembre 2011. l’âge moyen des patients était de 5 ans et 10 mois avec une prédominance masculine (65,4%). La tumeur était abdominale dans 80% des cas, thoracique dans 15% cas, thoracique et abdominale dans 2,5% et sacrée dans 1,2%. Les biopsies étaient écho-guidées dans 90% des cas et scannoguidées dans 10% des cas. Le diagnostic histopathologique était posé dans 89% des cas. L'immuno-histochimie a été indiquée dans 35% des cas. Les diagnostics les plus fréquents étaient: tumeurs neuroblastiques (42 cas), lymphomes non hodgkiniens (10 cas), rhabdomyosarcomes (6 cas), autres (sarcome d'Ewing, néphroblastomes, tumeur myofibroblastique inflammatoire, maladies de Hodgkin, leucémie aiguë, hépatoblastome et ostéosarcome). Dans notre série, la biopsie radioguidée a permis un diagnostic histopathologique certain dans 89% des cas. Elle nécessite une étroite collaboration entre clinicien, radiologue et anatomopathologiste pour discuter son indication, afin de diminuer le nombre de biopsies peu ou non représentatives. PMID:26587165

  8. Modélisation des profils de raie dans les plasmas : PPP nouvelle version

    NASA Astrophysics Data System (ADS)

    Calisti, A.; Ferri, S.; Mossé, C.

    2006-12-01

    Le code de calcul de profils de raie PPP a été développé à l'origine avec l'objectif de synthétiser les raies spectrales émises par les plasmas et ce pour n'importe quel émetteur et n'importe quelles conditions de plasmas. Les motivations de ce travail ont été d'une part le diagnostic et d'autre part les études de la dynamique non linéaire des charges dans les plasmas. Le code numérique basé sur des modèles originaux met en jeu des algorithmes qui réalisent le meilleur compromis entre précision et rapidité. En particulier, le mouvement des charges perturbatrices est pris en compte par le Modèle de Fluctuation de Fréquences qui transforme le profil statique en profil dynamique. Ce code a été sans cesse amélioré au cours des dix dernières années avec l'aide d'une technique de simulation numérique basée sur la méthode de dynamique moléculaire qui fournit des profils dits de référence.

  9. Gongjin-Dan Enhances Hippocampal Memory in a Mouse Model of Scopolamine-Induced Amnesia

    PubMed Central

    Lee, Jin-Seok; Hong, Sung-Shin; Kim, Hyeong-Geug; Lee, Hye-Won; Kim, Won-Yong; Lee, Sam-Keun; Son, Chang-Gue

    2016-01-01

    We evaluated the neuropharmacological effects of Gongjin-Dan (GJD) on the memory impairment caused by scopolamine injection. BALB/c mice were orally treated with GJD (100, 200, or 400 mg/kg, daily) or tacrine (THA, 10 mg/kg) for 10 days, and scopolamine (2 mg/kg) was injected intraperitoneally. The radial arm maze and passive avoidance tests were performed to evaluate the animal’s learning and memory. Scopolamine increased the task completing time, the number of total errors (reference and working memory error) in the radial arm maze task, and the latency time in the passive avoidance test, which were significantly ameliorated by treatment with GJD. The GJD treatment also attenuated the scopolamine-induced hyperactivation of acetylcholinesterase activity, and suppression of the expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and their receptors in the hippocampus. These effects of GJD were supported by both the doublecortin (DCX)-positive staining and Nissl staining, which were used to measure hippocampal neurogenesis and atrophy, respectively. These findings strongly suggest that GJD exerts a potent anti-amnesic effect, and its underlying mechanism might involve the modulation of cholinergic activity. PMID:27483466

  10. Diffusion Raman polarisée dans des systèmes orientés

    NASA Astrophysics Data System (ADS)

    Bréhamet, Lionel; Vandevyver, Michel

    On calcule pour la diffusion Raman les activités observables <αlm2> pour un système orienté uniaxialement, dans des conditions geométriques générales jamais examinées jusqu'ici. Le tenseur de polarisabilité Raman est arbitraire, la direction de l'axe directeur par rapport à un repère lié à l'échantillon est également arbitraire et le faisceau d'excitation arrive sur l'échantillon avec une incidence quelconque. Les résultats trouvés mettent en évidence des symétries fondamentales où les paramètres d'ordre sont simplement multipliés par d'autres polynômes de Legendre Pk dont l'argument reflète les conditions géométriques. Certaines situations particulières sont discutées.

  11. Amplification paramétrique de polaritons dans des microcavités semi-conductrices

    NASA Astrophysics Data System (ADS)

    Baas, A.; Karr, J.-P.; Courty, J.-M.; Giacobino, E.

    2002-06-01

    Nous étudions l'émission non linéaire de microcavités serai-conductrices en régime de couplage fort. Des expériences en régime d'excitation continue et résonante ont été récemment interprétées par un modèle de mélange paramétrique à quatre ondes de polaritons[1]. Nous avons retrouvé cette émission non linéaire dans une configuration nouvelle. Nous avons mis en évidence pour la première fois la dépendance en phase de l'émission, preuve de la cohérence du processus d'amplification. De plus, certaines quadratures du champ réfléchi ont des fluctuations réduites en dessous du bruit thermique, et proches de la limite quantique standardé[2

  12. Nouveautes Dans la Reconstruction Cutanee: Cultures de Cellules et Substituts Dermiques et Revue de la Litterature

    PubMed Central

    Koch, N.; Erba, P.; Benathan, M.; Raffoul, W.

    2010-01-01

    Summary La prise en charge de patients souffrant de brûlures profondes et étendues reste un défi important pour les chirurgiens reconstructeurs. Ceci est d'autant plus vrai que les grands progrès réalisés dans la réanimation assurent actuellement la survie de patients brûlés sur plus de 90% de leur surface corporelle. De ce fait la reconstruction moderne a dû innover et est devenue une chirurgie complexe nécessitant un plan stratégique impliquant des matériaux et des méthodes chirurgicales multiples adaptées à chaque situation clinique. Ce type de prise en charge nécessite aussi la collaboration étroite et coordonnée de plusieurs équipes hautement spécialisées. Le taux de survie ainsi que de la qualité de vie de ces patients sont alors nettement améliorés. De même nous observons clairement que le nombre de complications secondaires telles que les rétractions et les instabilités cicatricielles ont également diminué de façon significative. Mots-clés: brûlure, greffe, culture, substitut dermique, reconstruction PMID:21991212

  13. Mise en évidence d'états excités dans les spectres de photoionisation du cyclohexane et du diméthyl 2-2-butane liquides

    NASA Astrophysics Data System (ADS)

    Casanovas, J.; Guelfucci, J. P.; Caselles, O.

    1991-07-01

    Excited states are probably occurring, at an intermediate stage, in the VUV photoionization process of liquid hydrocarbons, as suggested by a Stern-Volmer behaviour when interacting with electron quenchers. They are here detected in the VUV photoionization spectrum of cyclohexane and dimethyl-2-2-butane in liquid phase. Some of the discernable peaks can be assigned as valence and Rydberg states, yet observed in gas phase. Supplementary peaks are observed, the existence of which is to be interpretated. L'existence d'états excités dans le processus de photoionisation VUV des hydrocarbures en phase liquide - précédemment suggérée par l'observation de la loi de Stern-Volmer lors de l'interaction avec des capteurs d'électrons - est ici détectée en traçant le spectre de photoionisation VUV du cyclohexane et du diméthyl-2-2-butane purs en phase liquide. Certains des pics observés coïncident avec les états de valence et de Rydberg de ces mêmes corps en phase gaz. Il apparaît des pics supplémentaires dont la nature doit être précisée.

  14. DAN instrument for NASA`s MSL mission: fast science data processing and instrument commanding for Mars surface operations and for field tests

    NASA Astrophysics Data System (ADS)

    Vostrukhin, A.; Kozyrev, A.; Litvak, M.; Malakhov, A.; Mitrofanov, I.; Mokrousov, M.; Sanin, A.; Tretyakov, V.

    2009-04-01

    The Dynamic Albedo of Neutrons (DAN) instrument is contributed by Russian Space Agency to NASA for Mars Science Laboratory mission which was originally scheduled for 2009 and now is shifted to 2011. The design of DAN instrument is partially inherited from HEND instrument for NASA's Mars Odyssey, which now successfully operates providing global mapping of martian neutron albedo, searching the distribution of martian water and observing the martian seasonal cycles. DAN is specially designed as an active neutron instrument for surface operations onboard mobile platforms. It is able to focus science investigations on local surface area around rover with horizontal resolution about 1 meter and vertical penetration about 0.5 m. The primary goal of DAN is the exploration of the hydrogen content of the bulk Martian subsurface material. This data will be used to estimate the content of chemically bound water in the hydrated minerals. The concept of DAN operations is based on combination of neutron activation analysis and neutron well logging tequnique, which are commonly used in the Earth geological applications. DAN consists blocks of Detectors and Electronics (DE) and Pulse Neutron Generator (PNG). The last one is used to irradiate the martian subsurface by pulses of 14MeV neutrons with changeable frequency up to 10 Hz. The first one detects post-pulse afterglow of neutrons, as they were thermalized down to epithermal and thermal energies within the martian subsurface. The result of detections are so called die away curves of neutrons afterglow, which show flux and time profile of thermalized neutrons and bring to us the observational signature of layering structure of martian regolith in part of depth distribution of Hydrogen (most effective element for thermalization of neutrons). In this study we focus on the development, verification and validation of DAN fast data processing and commanding. It is necessary to perform deconvolution from counting statistic in DAN

  15. Source X par agrégats : contrôle et optimisation des paramètres gouvernant l'interaction laser de puissance agrégats de gaz rare

    NASA Astrophysics Data System (ADS)

    Lamour, E.; Prigent, C.; Rozet, J. P.; Vernhet, D.; Gobert, O.; Meynadier, P.; Normand, D.; Perdrix, M.

    2005-06-01

    Les expériences que nous avons réalisées sur le Laser Ultra Court Accordable du CEA Saclay permettent d'observer l'émission de photons X dans la gamme 1-5 keV lors de l'irradiation d'agrégats de gaz rare (Ar, Kr et Xe comprenant entre 103 et 106 atomes par agrégat) avec un laser femtoseconde de puissance (Ipic jusqu'à 1017 W/cm2). En plus de la distribution des états de charge des ions responsables de l'émission X, la technique de spectroscopie X que nous utilisons permet de mesurer les taux absolus de photons émis dans 4π par impulsion laser en fonction des paramètres gouvernant l'interaction dans des conditions contrôlées. Nous avons déterminé la sensibilité des paramètres physiques régissant la production du rayonnement X pendant l'interaction, ce qui permet d'accéder à l'optimisation de cette source. Cet article est plus particulièrement dédié aux résultas relatifs à l'évolution du taux d'X avec l'éclairement laser, d'une part, et avec la durée de l'impulsion laser, d'autre part.

  16. Electronically Enhanced Classroom Interaction.

    ERIC Educational Resources Information Center

    Draper, Stephen; Cargill, Julie; Cutts, Quintin

    A design rationale for introducing electronic equipment (a group response system) for student interaction in lecture theaters is presented, linking the instructional design to theory. The effectiveness of the equipment for learning depends mostly on what pedagogic method is employed. Various alternative types are introduced, including: assessment;…

  17. Interactive Tabletops in Education

    ERIC Educational Resources Information Center

    Dillenbourg, Pierre; Evans, Michael

    2011-01-01

    Interactive tabletops are gaining increased attention from CSCL researchers. This paper analyses the relation between this technology and teaching and learning processes. At a global level, one could argue that tabletops convey a socio-constructivist flavor: they support small teams that solve problems by exploring multiple solutions. The…

  18. Teaching with Interactive Multimedia.

    ERIC Educational Resources Information Center

    Hudson, Tim

    Based on the idea that anyone who is interested in making entertaining and informative presentations in educational settings is interested in multimedia, this practical guide offers tips for communication (and other) teachers who want to integrate and program interactive multimedia into their courses. The guide suggests that teachers on limited…

  19. Teleconferencing and Interactive Media.

    ERIC Educational Resources Information Center

    Parker, Lorne A., Comp.; Olgren, Christine H., Comp.

    This publication contains more than 50 papers on the latest developments and applications of interactive media to link distant locations. The contributors, who represent business, government, education, medical, and telecommunications organizations in the United States, Canada, England, and Australia, have had direct experience with the full range…

  20. Designing Interactive Learning Systems.

    ERIC Educational Resources Information Center

    Barker, Philip

    1990-01-01

    Describes multimedia, computer-based interactive learning systems that support various forms of individualized study. Highlights include design models; user interfaces; design guidelines; media utilization paradigms, including hypermedia and learner-controlled models; metaphors and myths; authoring tools; optical media; workstations; four case…

  1. Interactive Genetics Tutorial Project.

    ERIC Educational Resources Information Center

    Wisconsin Univ., Madison. Dept. of Curriculum and Instruction.

    The Interactive Genetics Tutorial (IGT) project and the Intelligent Tutoring System for the IGT project named MENDEL supplement genetics instruction in biology courses by providing students with experience in designing, conducting, and evaluating genetics experiments. The MENDEL software is designed to: (1) simulate genetics experiments that…

  2. Interactive shape metamorphosis

    NASA Technical Reports Server (NTRS)

    Chen, David T.; State, Andrei; Banks, David

    1994-01-01

    A technique for controlled metamorphosis between surfaces in 3-space is described. Well-understood techniques to produce shape metamorphosis between models in a 2D parametric space is applied. The user selects morphable features interactively, and the morphing process executes in real time on a high-performance graphics multicomputer.

  3. Latent Variable Interaction Modeling.

    ERIC Educational Resources Information Center

    Schumacker, Randall E.

    2002-01-01

    Used simulation to study two different approaches to latent variable interaction modeling with continuous observed variables: (1) a LISREL 8.30 program and (2) data analysis through PRELIS2 and SIMPLIS programs. Results show that parameter estimation was similar but standard errors were different. Discusses differences in ease of implementation.…

  4. Interaction Information Retrieval.

    ERIC Educational Resources Information Center

    Dominich, Sandor

    1994-01-01

    Discussion of information retrieval focuses on an Interaction Information Retrieval model in which documents are interconnected; queries and documents are treated in the same way; and retrieval is the result of the interconnection between query and documents. A theoretical mathematical formulation of this type of retrieval is given. (Contains 31…

  5. Interactive Mold House Tour

    EPA Pesticide Factsheets

    Get a quick glimpse of some of the most important ways to protect your home from mold by this interactive tour of the Mold House. Room-by-room, you'll learn about common mold issues and how to address them.

  6. Dimensions of Group Interaction

    ERIC Educational Resources Information Center

    Dawidowicz, Paula

    2008-01-01

    The correlation between positive and negative group interactions and one or another of individuals' attitudes or characteristics--moral development, critical thinking, resilience, and self efficacy--has been examined previously. However, no systemic examination of individuals' development of patterns of these characteristics and those patterns'…

  7. Connectionist Interaction Information Retrieval.

    ERIC Educational Resources Information Center

    Dominich, Sandor

    2003-01-01

    Discussion of connectionist views for adaptive clustering in information retrieval focuses on a connectionist clustering technique and activation spreading-based information retrieval model using the interaction information retrieval method. Presents theoretical as well as simulation results as regards computational complexity and includes…

  8. Magnetosphere-ionosphere interactions

    NASA Technical Reports Server (NTRS)

    Vondrak, R. R.; Chiu, Y. T.; Evans, D. S.; Patterson, V. G.; Romick, G. J.; Stasiewicz, K.

    1979-01-01

    The present understanding of magnetosphere ionosphere interactions is described, and present and future predictive capabilities are assessed. Ionospheric features directly coupled to the magnetosphere to a significant degree are considered, with emphasis given to those phenomena of major interest to forecasters and users.

  9. Data Interactive Publications Revisited

    NASA Astrophysics Data System (ADS)

    Domenico, B.; Weber, W. J.

    2011-12-01

    A few years back, the authors presented examples of online documents that allowed the reader to interact directly with datasets, but there were limitations that restricted the interaction to specific desktop analysis and display tools that were not generally available to all readers of the documents. Recent advances in web service technology and related standards are making it possible to develop systems for publishing online documents that enable readers to access, analyze, and display the data discussed in the publication from the perspective and in the manner from which the author wants it to be represented. By clicking on embedded links, the reader accesses not only the usual textual information in a publication, but also data residing on a local or remote web server as well as a set of processing tools for analyzing and displaying the data. With the option of having the analysis and display processing provided on the server, there are now a broader set of possibilities on the client side where the reader can interact with the data via a thin web client, a rich desktop application, or a mobile platform "app." The presentation will outline the architecture of data interactive publications along with illustrative examples.

  10. Data Interactive Publications

    NASA Astrophysics Data System (ADS)

    Domenico, B.; Weber, J.

    2012-04-01

    For some years now, the authors have developed examples of online documents that allowed the reader to interact directly with datasets, but there were limitations that restricted the interaction to specific desktop analysis and display tools that were not generally available to all readers of the documents. Recent advances in web service technology and related standards are making it possible to develop systems for publishing online documents that enable readers to access, analyze, and display the data discussed in the publication from the perspective and in the manner from which the author wants it to be represented. By clicking on embedded links, the reader accesses not only the usual textual information in a publication, but also data residing on a local or remote web server as well as a set of processing tools for analyzing and displaying the data. With the option of having the analysis and display processing provided on the server (or in the cloud), there are now a broader set of possibilities on the client side where the reader can interact with the data via a thin web client, a rich desktop application, or a mobile platform "app." The presentation will outline the architecture of data interactive publications along with illustrative examples.

  11. Interaction, 1996-1997.

    ERIC Educational Resources Information Center

    Hajdu-Vaughn, Susan, Ed.; Coyle, Barbara, Ed.

    1997-01-01

    This collection includes four quarterly issues of "Interaction," a publication of the Canadian Child Care Federation. Each issue addresses several topics and is arranged in four sections: opinions, practice/pratique, focus/a propos, and news/nouvelles. The opinions section includes letters and editorial/review columns, the practice…

  12. GENIE final state interactions

    SciTech Connect

    Dytman, Steven

    2015-10-15

    Final state interactions are an important component of any neutrino-nucleus Monte Carlo program. GENIE has 2 FSI programs which serve different purposes. Each has fair-good agreement with a wide range of hadron-nucleus data. Recent improvements and planned advancements are described.

  13. Interactions of cosmic superstrings

    SciTech Connect

    Jackson, Mark G.; /Fermilab

    2007-06-01

    We develop methods by which cosmic superstring interactions can be studied in detail. These include the reconnection probability and emission of radiation such as gravitons or small string loops. Loop corrections to these are discussed, as well as relationships to (p; q)-strings. These tools should allow a phenomenological study of string models in anticipation of upcoming experiments sensitive to cosmic string radiation.

  14. Interactive Technology for Education.

    ERIC Educational Resources Information Center

    Brooks, Robert; Perl, Barry

    1991-01-01

    By using the kind of two-way television system envisioned by Buckminster Fuller, school children can learn at their own rates and select interesting topics, thereby continually reinforcing the desire to learn. Today's new interactive video systems, from multimedia encyclopedias to hypermedia combinations, allow students to explore subject matter…

  15. Electron interaction in matter

    NASA Technical Reports Server (NTRS)

    Dance, W. E.; Rainwater, W. J.; Rester, D. H.

    1969-01-01

    Data on the scattering of 1-MeV electrons in aluminum for the case of non-normal incidence, electron-bremsstrahlung cross-sections in thin targets, and the production of bremstrahlung by electron interaction in thick targets, are presented both in tabular and graphic form. These results may interest physicists and radiologists.

  16. Standardizing Interaction Design Education

    ERIC Educational Resources Information Center

    Thomassen, Aukje; Ozcan, Oguzhan

    2010-01-01

    The objective of this paper is to which extend the didactic format of studio-based group-work is applicable for creating a common-ground for Interaction Design Education in European Perspective. The current debate on design education shows us a landscape of different initiatives. So far difficulties have arisen in the area of accreditation and…

  17. Interactive Reflective Logs

    ERIC Educational Resources Information Center

    Deaton, Cynthia Minchew; Deaton, Benjamin E.; Leland, Katina

    2010-01-01

    The authors created an interactive reflective log (IRL) to provide teachers with an opportunity to use a journal approach to record, evaluate, and communicate student understanding of science concepts. Unlike a traditional journal, the IRL incorporates prompts to encourage students to discuss their understanding of science content and science…

  18. Embarrassment in Dyadic Interaction.

    ERIC Educational Resources Information Center

    Edelmann, Robert J.; Hampson, Sarah E.

    1981-01-01

    Subject pairs (N=18) participated in an alternating question-and-answer session at one of two interactional distances utilizing questions which increased in their intimacy content. Results indicated topic intimacy, but not distance, affected the embarrassment potential of the situation. Increases in embarrassment caused changes in nonverbal and…

  19. A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines.

    PubMed

    Song, Hui-Peng; Wu, Si-Qi; Hao, Haiping; Chen, Jun; Lu, Jun; Xu, Xiaojun; Li, Ping; Yang, Hua

    2016-03-30

    Two concepts involving natural products were proposed and demonstrated in this paper. (1) Natural product libraries (e.g. herbal extract) are not perfect for bioactivity screening because of the vast complexity of compound compositions, and thus a library reconstruction procedure is necessary before screening. (2) The traditional mode of "screening single compound" could be improved to "screening single compound, drug combination and multicomponent interaction" due to the fact that herbal medicines work by integrative effects of multi-components rather than single effective constituents. Based on the two concepts, we established a novel strategy aiming to make screening easier and deeper. Using thrombin as the model enzyme, we firstly uncovered the minor lead compounds, potential drug combinations and multicomponent interactions in an herbal medicine of Dan-Qi pair, showing a significant advantage over previous methods. This strategy was expected to be a new and promising mode for investigation of herbal medicines.

  20. Etude experimentale de la photoexcitation des colorants de type anthracene, azobenzene et thioindigo dans des matrices de cristaux liquides nematiques et smectiques

    NASA Astrophysics Data System (ADS)

    Saad, Bendaoud

    Nous avons étudié le comportement de différents colorants (tétracène et azobenzènes AZD3, DR1 et D2) dans des matrices de cristaux liquides (E7 et 5CB). Les résultats obtenus ont montré que la réorientation optique des molécules de cristaux liquides se produit à des intensités extrêmement faibles (~1 μW/cm 2). Nous avons attribué cet effet à l'interaction entre les molécules des colorants photoexcitées et celles des cristaux liquides hôtes. Ces interactions se produisent lorsque les molécules dichroïques exçitées transitent entre des états triplets intermédiaires tout en conduisant à la génération d'un nouveau moment optique géant, responsable de la réorientation des molécules. Le changement de la forme de la molécule du colorant, dû à l'isomérisation Trans-Cis , est à l'origine de la création de ce moment. Ce qui distingue notre réorientation moléculaire de celle obtenue sur d'autres systèmes hôtes-dopants est que les molécules sont repoussées du champ électrique de la lumière. Par ailleurs, cette réorientation est accompagnée d'une diffusion anisotrope des molécules excitées. Nous avons aussi étudié le cristal liquide PhBz rendu ferroélectrique en le dopant par des molécules thioindigos. En exploitant l'augmentation de la polarisation spontanée due à la photoisomérisation du colorant, nous avons pu réaliser un hologramme dynamique contrôlable par un champ optique assisté par une tension statique.

  1. Tetrel Bonding Interactions.

    PubMed

    Bauzá, Antonio; Mooibroek, Tiddo J; Frontera, Antonio

    2016-02-01

    Tetrel (Tr) bonding is first placed into perspective as a σ-hole bonding interaction with atoms of the Tr family. An sp(3) R4Tr unit has four σ-holes with which a Lewis base can form a complex. We then highlight some inspiring crystal structures where Tr bonding is obvious, followed by an account of our own work. We have shown that Tr bonding is ubiquitous in the solid state and we have highlighted that Tr bonding with carbon is possible when C is placed in the appropriate chemical context. We hope that this account serves as an initial guide and source of inspiration for others wishing to exploit this vastly underexplored interaction.

  2. Interactive design center.

    SciTech Connect

    Pomplun, Alan R. (Sandia National Laboratories, Livermore, CA)

    2005-07-01

    Sandia's advanced computing resources provide researchers, engineers and analysts with the ability to develop and render highly detailed large-scale models and simulations. To take full advantage of these multi-million data point visualizations, display systems with comparable pixel counts are needed. The Interactive Design Center (IDC) is a second generation visualization theater designed to meet this need. The main display integrates twenty-seven projectors in a 9-wide by 3-high array with a total display resolution of more than 35 million pixels. Six individual SmartBoard displays offer interactive capabilities that include on-screen annotation and touch panel control of the facility's display systems. This report details the design, implementation and operation of this innovative facility.

  3. Neutrinophilic nonstandard interactions

    NASA Astrophysics Data System (ADS)

    Farzan, Yasaman; Heeck, Julian

    2016-09-01

    We construct UV-complete models for nonstandard neutrino interactions mediated by a sub-GeV gauge boson Z' coupled to baryon number B or B -L . A flavor-dependent Z' coupling to neutrinos is induced by mixing a U (1 )'-charged Dirac fermion with the active neutrinos, naturally suppressing flavor violation or nonuniversality of the charged leptons to the loop level. We show that these models can give rise to large flavor-conserving as well as flavor-violating nonstandard neutral-current neutrino interactions potentially observable in current or future oscillation experiments such as DUNE without being in conflict with other constraints such as neutrino scattering or lepton-flavor-violating decays. In particular, the LMA-Dark solution to the solar-neutrino anomaly can be obtained for U (1 )B, but not for U (1 )B-L.

  4. Combustor diffuser interaction program

    NASA Technical Reports Server (NTRS)

    Srinivasan, Ram; Thorp, Daniel

    1986-01-01

    Advances in gas turbine engine performance are achieved by using compressor systems with high stage loading and low part count, which result in high exit Mach numbers. The diffuser and combustor systems in such engines should be optimized to reduce system pressure loss and to maximize the engine thrust-to-weight ratio and minimize length. The state-of-the-art combustor-diffuser systems do not meet these requirements. Detailed understanding of the combustor-diffuser flow field interaction is required for designing advanced gas turbine engines. An experimental study of the combustor-diffuser interaction (CDI) is being conducted to obtain data for the evaluation and improvement of analytical models applicable to a wide variety of diffuser designs. The CDI program consists of four technical phases: Literature Search; Baseline Configuration; Parametric Configurations; and Performance Configurations. Phase 2 of the program is in progress.

  5. Interactive optical panel

    DOEpatents

    Veligdan, J.T.

    1995-10-03

    An interactive optical panel assembly includes an optical panel having a plurality of ribbon optical waveguides stacked together with opposite ends thereof defining panel first and second faces. A light source provides an image beam to the panel first face for being channeled through the waveguides and emitted from the panel second face in the form of a viewable light image. A remote device produces a response beam over a discrete selection area of the panel second face for being channeled through at least one of the waveguides toward the panel first face. A light sensor is disposed across a plurality of the waveguides for detecting the response beam therein for providing interactive capability. 10 figs.

  6. Evolution of intrafamilial interactions.

    PubMed Central

    Lynch, M

    1987-01-01

    A theory for the evolution of behavioral interactions among relatives is developed that allows for genetic correlations between the types of behavior that are expressed in different social contexts. Both theoretical and empirical considerations indicate that such genetic constraints will almost certainly be common in natural populations. It is shown that when genetic correlations between elements of social behavior exist, Hamilton's rule inaccurately describes the conditions for evolution by way of kin selection. The direction in which social organization evolves is a delicate function of the genetic covariance structure among behaviors expressed as an offspring, sibling, parent, etc. A change in this covariance structure caused by random genetic drift or by a change in environment for a population exhibiting genotype-environment interaction can cause the population to suddenly cross a threshold into a new selective domain. Consequently, radical changes in social organization may arise between closely related species without any major shift in selective pressures external to the population. Images PMID:3479804

  7. Volcanism-Climate Interactions

    NASA Technical Reports Server (NTRS)

    Walter, Louis S. (Editor); Desilva, Shanaka (Editor)

    1991-01-01

    The range of disciplines in the study of volcanism-climate interactions includes paleoclimate, volcanology, petrology, tectonics, cloud physics and chemistry, and climate and radiation modeling. Questions encountered in understanding the interactions include: the source and evolution of sulfur and sulfur-gaseous species in magmas; their entrainment in volcanic plumes and injection into the stratosphere; their dissipation rates; and their radiative effects. Other issues include modeling and measuring regional and global effects of such large, dense clouds. A broad-range plan of research designed to answer these questions was defined. The plan includes observations of volcanoes, rocks, trees, and ice cores, as well as satellite and aircraft observations of erupting volcanoes and resulting lumes and clouds.

  8. Interactive optical panel

    DOEpatents

    Veligdan, James T.

    1995-10-03

    An interactive optical panel assembly 34 includes an optical panel 10 having a plurality of ribbon optical waveguides 12 stacked together with opposite ends thereof defining panel first and second faces 16, 18. A light source 20 provides an image beam 22 to the panel first face 16 for being channeled through the waveguides 12 and emitted from the panel second face 18 in the form of a viewable light image 24a. A remote device 38 produces a response beam 40 over a discrete selection area 36 of the panel second face 18 for being channeled through at least one of the waveguides 12 toward the panel first face 16. A light sensor 42,50 is disposed across a plurality of the waveguides 12 for detecting the response beam 40 therein for providing interactive capability.

  9. Interactive chemical reactivity exploration.

    PubMed

    Haag, Moritz P; Vaucher, Alain C; Bosson, Maël; Redon, Stéphane; Reiher, Markus

    2014-10-20

    Elucidating chemical reactivity in complex molecular assemblies of a few hundred atoms is, despite the remarkable progress in quantum chemistry, still a major challenge. Black-box search methods to find intermediates and transition-state structures might fail in such situations because of the high-dimensionality of the potential energy surface. Here, we propose the concept of interactive chemical reactivity exploration to effectively introduce the chemist's intuition into the search process. We employ a haptic pointer device with force feedback to allow the operator the direct manipulation of structures in three dimensions along with simultaneous perception of the quantum mechanical response upon structure modification as forces. We elaborate on the details of how such an interactive exploration should proceed and which technical difficulties need to be overcome. All reactivity-exploration concepts developed for this purpose have been implemented in the samson programming environment.

  10. Interactive protein manipulation

    SciTech Connect

    SNCrivelli@lbl.gov

    2003-07-01

    We describe an interactive visualization and modeling program for the creation of protein structures ''from scratch''. The input to our program is an amino acid sequence -decoded from a gene- and a sequence of predicted secondary structure types for each amino acid-provided by external structure prediction programs. Our program can be used in the set-up phase of a protein structure prediction process; the structures created with it serve as input for a subsequent global internal energy minimization, or another method of protein structure prediction. Our program supports basic visualization methods for protein structures, interactive manipulation based on inverse kinematics, and visualization guides to aid a user in creating ''good'' initial structures.

  11. The interactive videodisc.

    PubMed

    Leveridge, L L

    1983-04-01

    Dynamic audiovisual presentations that are interactive due to the use of videodisc systems provide more efficient and effective communication of those elements of medicine best learned by seeing them, than is possible via traditional modes. This is particularly true when externally interfaced electronic data processors are used to automate the process. While magnetic and stylus-type videodisc players can serve in education, it is the optical videodisc that has the greatest educational potential. The AMA has been exploring the capabilities of optical videodisc systems and demonstrating pilot programs that use good principles of audiovisual and computer-assisted instruction in tutorial formats or presented as patient management problems. We are on the threshold of a revolution in communication potentially as significant to education as the one which followed the invention of movable type. Using interactive videodisc programs, designed and produced with skill and care, we can solve some of medical education's most pressing problems.

  12. Interactive digital signal processor

    NASA Technical Reports Server (NTRS)

    Mish, W. H.; Wenger, R. M.; Behannon, K. W.; Byrnes, J. B.

    1982-01-01

    The Interactive Digital Signal Processor (IDSP) is examined. It consists of a set of time series analysis Operators each of which operates on an input file to produce an output file. The operators can be executed in any order that makes sense and recursively, if desired. The operators are the various algorithms used in digital time series analysis work. User written operators can be easily interfaced to the sysatem. The system can be operated both interactively and in batch mode. In IDSP a file can consist of up to n (currently n=8) simultaneous time series. IDSP currently includes over thirty standard operators that range from Fourier transform operations, design and application of digital filters, eigenvalue analysis, to operators that provide graphical output, allow batch operation, editing and display information.

  13. Émission spontanée amplifiée (ÉSA) dans une structure à double cavité verticale (Bi-VCSEL)

    NASA Astrophysics Data System (ADS)

    Boucher, Y.; Gayraud, L.

    2004-11-01

    Nous présentons une étude théorique de l'Émission Spontanée Amplifiée dans une structure verticale à double cavité, décrite en termes de couplage d'ondes. Chaque cavité y est représentée par un saut de phase, tandis que les puits quantiques sont assimilés à des singularités de Dirac de la permittivité. Les sources sont prises en compte dans le cadre du formalisme des matrices de transfert étendues (3 × 3), qui inclut la saturation des zones actives sous l'effet du champ interne. Dans le plan spectral, celui-ci apparaît, au même titre que le champ émis, filtré par la fonction de transfert bimode de la structure.

  14. Baisse du HDL-cholestérol indicateur du stress oxydatif dans le diabète de type 2

    PubMed Central

    Kabamba, Arsène Tshikongo; Bakari, Salvius Amuri; Longanga, Albert Otshudi; Lukumwena, Zet Kalala

    2014-01-01

    L'hypercholestérolémie est étroitement liée au stress oxydatif. Lorsqu'il y a trop de cholestérol qui circule dans le sang, il n'est pas utilisé en totalité par les cellules et il risque de s'accumuler dans les vaisseaux sanguins. Cela peut entrainer la formation des plaques d'athérosclérose qui gênent la circulation sanguine et provoquent des accidents cardiovasculaires. Le stress oxydatif apparait très tôt dans l'histoire des complications du diabète de type 2, et est lié à l'oxydation du glucose mais aussi à la peroxydation lipidique. Le cholestérol-HDL est un marqueur important du stress oxydatif par sa capacité à faciliter la métabolisation du cholestérol, sa baisse est souvent considérée comme la source de beaucoup d'inquiétudes. L'objectif est l’évaluation de la variation du taux de cholestérol-HDL, marqueur du stress oxydatif, chez les patients diabétiques de type 2 dans la population congolaise. Nous avons inclus dans cette étude prospective des cas témoins des patients diabétiques de type 2 reconnus et diagnostiqués, et des témoins non diabétiques appariés selon l’âge et le sexe. Parallèlement au bilan biologique classique, une analyse d'un des facteurs de risque du stress oxydatif a été réalisée: baisse de HDL-Cholestérol. L’âge moyen des 30 patients diabétiques (47,77±10,78 ans) était comparable à celui des 30 témoins (48,83±10,73 ans). Une baisse significative du cholestérol-HDL dans le sang était observée chez 100% des diabétiques et 50% des témoins (p=0,0000). L'augmentation du HDL cholestérol permet d’éliminer le mauvais cholestérol en excès en nettoyant les tissus et en ramenant le cholestérol vers le foie. Lors du diabète de type 2 on constate une baisse sanguine sensible du taux de HDL-cholestérol, qui est signe indicateur du stress oxydatif. PMID:25767660

  15. Apport de l’IRM dans la prise en charge des compressions médullaires lentes non traumatiques

    PubMed Central

    Badji, Nfally; Deme, Hamidou; Akpo, Geraud; Ndong, Boucar; Toure, Mouhamadou Hamine; Diop, Sokhna Ba; Niang, El Hadji

    2016-01-01

    Les compressions médullaires lentes sont dues au développement dans le canal médullaire d’une lésion expansive. C’est une pathologie très fréquente dont le diagnostic est essentiellement clinique. L’imagerie par résonnance magnétique occupe une place incontournable dans le diagnostic de localisation et la recherche étiologique. En Europe l’étiologie tumorale est prépondérante. Le but de cette étude était de décrire les aspects IRM des compressions médullaires lentes et de déterminer le profil étiologique. Il s’agit d’une étude rétrospective portant sur 97 observations colligées au service de radiologie du CHUN de Fann sur une période de 30 mois (du 08/03/10 au 29/09/12). On été inclus dans l’étude, tous les patients adressés pour un tableau de compression médullaire lente survenu dans un contexte non traumatique. L’âge moyen des patients était de 42,6 ans avec des extrêmes compris entre 04 mois et 85 ans. Nous avons étudié la topographie des lésions (étage rachidien, compartiments canalaires) leur rehaussement et les critères d’orientation étiologique. Le protocole d’examen permettait la réalisation de séquence pondérées T1 sans avec injection de gado, T2, STIR et T2 DRIVE centrées sur les niveaux lésionnels ou les zones suspectes. L’IRM a permis de préciser le siège exact et l’étendue des lésions. L’atteinte du rachis dorsal représentait 42% des cas, suivi du rachis cervical avec 32% des cas. Les atteintes lombo-sacrées et pluri-étagées représentaient respectivement 18% et 08% des cas. Les lésions extradurales représentaient 87% des cas, suivi des lésions intradurales extramédullaires avec 08% des cas et des lésions intramédullaires dans 05% des cas. La particularité du profil étiologique de notre étude est la prédominance des épidurites infectieuses et la fréquence relative des épidurites métastatiques comparée aux séries occidentales. L’IRM vertébro-médullaire occupe

  16. La place de la thoracoscopie dans la prise en charge des pathologies thoraciques: à propos de 104 cas

    PubMed Central

    Lakranbi, Marwane; Rabiou, Sani; Ghalimi, Jamal; Issoufou, Ibrahim; Ouadnouni, Yassine; Smahi, Mohamed

    2015-01-01

    Introduction La thoracoscopie est l'exploration endoscopique de la cavité pleurale, des organes avoisinants (diaphragme, péricarde, médiastin) et du poumon. Le but de ce travail se veut d'abord didactique; décrivant la thoracoscopie, ses techniques ainsi que sa place dans la prise en charge de la pathologie thoracique (indications et perspectives thérapeutiques) et informatif en rapportant l'expérience de notre équipe. Méthodes Il s'agit d'une étude rétrospective intéressant 104 thoracoscopies à visée diagnostique et/ou thérapeutique réalisées au service de chirurgie thoracique du Centre Hospitalier Universitaire Hassan II de Fès, sur une période de 04 ans (Août 2008-décembre 2012). Nous avons exclu de notre étude les cas ayant bénéficié d'une médiastinoscopie ainsi que les cas ayant bénéficié d'une thoracoscopie dans le cadre des traumatismes fermés du thorax ou des plaies thoraciques. Résultats L’ âge moyen des patients est de 47 ans, avec des extrêmes allant de 18 à 80 ans, et une légère prédominance masculine à 54%. La thoracoscopie est d'ordre pleural chez 86 patients, pulmonaire chez 10 patients et médiastinale chez 8 patients. La thoracoscopie avait une indication à visée diagnostique chez 87 cas et thérapeutique chez 52 patients (talcage dans 45 cas, décortication pleuropulmonaire dans 2 cas, résection de kystepleuro-péricardique dans 2 cas, cure de pneumothorax dans 2 cas et une fenêtre péricardique). L’évolution post opératoire etait marquée par une amélioration clinico-radiologique chez 40 malades, 11 ont présenté une amélioration clinique seule, 6 ont présenté une persistance ou une récidive de l’épanchement. Conclusion La thoracoscopie représente un réel gain en matière de diagnostic de certaines pathologies intra-thoraciques. Son intérêt thérapeutique limité doit être éventuellement étendu grâce à la chirurgie thoracique vidéo assistée, qui est une technique récente fiable

  17. Acousto-Optic Interactions.

    DTIC Science & Technology

    The document reports the results of the experimental and theoretical investigation of acousto - optic interactions in guided wave structure for optical...waves and acoustic surface waves and experimental results of isotropic and anisotropic diffraction in LiNbO3 and quartz. A simple acousto - optic plate...CVD ZnO films on sapphire, which may be needed for the acousto - optic devices in thin films are also included. (Author)

  18. Mesoscale/convective interaction

    NASA Technical Reports Server (NTRS)

    Haines, P. A.; Sun, W. Y.

    1988-01-01

    A novel cumulus parameterization scheme (CPS) has been developed in order to account for mesoscale/convective-scale interaction which considers both the mesoscale and convective scale mass and moisture budgets, under the assumption that the heating rate is a maximum for given environmental conditions. The basis of the CPS is a detailed, quasi-one-dimensional cloud model that calculates mass and moisture fluxes similar to those calculated by the Schlesinger (1978) three-dimensional model.

  19. Interacting warm dark matter

    SciTech Connect

    Cruz, Norman; Palma, Guillermo; Zambrano, David; Avelino, Arturo E-mail: guillermo.palma@usach.cl E-mail: avelino@fisica.ugto.mx

    2013-05-01

    We explore a cosmological model composed by a dark matter fluid interacting with a dark energy fluid. The interaction term has the non-linear λρ{sub m}{sup α}ρ{sub e}{sup β} form, where ρ{sub m} and ρ{sub e} are the energy densities of the dark matter and dark energy, respectively. The parameters α and β are in principle not constrained to take any particular values, and were estimated from observations. We perform an analytical study of the evolution equations, finding the fixed points and their stability properties in order to characterize suitable physical regions in the phase space of the dark matter and dark energy densities. The constants (λ,α,β) as well as w{sub m} and w{sub e} of the EoS of dark matter and dark energy respectively, were estimated using the cosmological observations of the type Ia supernovae and the Hubble expansion rate H(z) data sets. We find that the best estimated values for the free parameters of the model correspond to a warm dark matter interacting with a phantom dark energy component, with a well goodness-of-fit to data. However, using the Bayesian Information Criterion (BIC) we find that this model is overcame by a warm dark matter – phantom dark energy model without interaction, as well as by the ΛCDM model. We find also a large dispersion on the best estimated values of the (λ,α,β) parameters, so even if we are not able to set strong constraints on their values, given the goodness-of-fit to data of the model, we find that a large variety of theirs values are well compatible with the observational data used.

  20. ELEMENTARY PARTICLE INTERACTIONS

    SciTech Connect

    EFREMENKO, YURI; HANDLER, THOMAS; KAMYSHKOV, YURI; SIOPSIS, GEORGE; SPANIER, STEFAN

    2013-07-30

    The High-Energy Elementary Particle Interactions group at UT during the last three years worked on the following directions and projects: Collider-based Particle Physics; Neutrino Physics, particularly participation in “NOνA”, “Double Chooz”, and “KamLAND” neutrino experiments; and Theory, including Scattering amplitudes, Quark-gluon plasma; Holographic cosmology; Holographic superconductors; Charge density waves; Striped superconductors; and Holographic FFLO states.

  1. [Brain-gut interactions].

    PubMed

    Bonaz, B

    2010-08-01

    Our digestive tract has an autonomous functioning but also has a bidirectional relation with our brain known as brain-gut interactions. This communication is mediated by the autonomous nervous system, i.e., the sympathetic and parasympathetic nervous systems, with a mixed afferent and efferent component, and the circumventricular organs located outside the blood-brain barrier. The vagus nerve, known as the principal component of the parasympathetic nervous system, is a mixed nerve composed of 90% afferent fibers, which has physiological roles due to its putative vegetative functions. The vagus nerve has also anti-inflammatory properties both through the hypothalamic pituitary adrenal axis (through its afferents) and the cholinergic anti-inflammatory pathway (through its efferents). The sympathetic nervous system has a classical antagonist effect on the parasympathetic nervous system at the origin of an equilibrated sympathovagal balance in normal conditions. The brain is able to integrate inputs coming from the digestive tract inside a central autonomic network organized around the hypothalamus, limbic system and cerebral cortex (insula, prefrontal, cingulate) and in return to modify the autonomic nervous system and the hypothalamic pituitary adrenal axis in the frame of physiological loops. A dysfunction of these brain-gut interactions, favoured by stress, is most likely involved in the pathophysiology of digestive diseases such as irritable bowel syndrome or even inflammatory bowel diseases. A better knowledge of these brain-gut interactions has therapeutic implications in the domain of pharmacology, neurophysiology, behavioural and cognitive management.

  2. Transactional interactive multimedia banner

    NASA Astrophysics Data System (ADS)

    Shae, Zon-Yin; Wang, Xiping; von Kaenel, Juerg

    2000-05-01

    Advertising in TV broadcasting has shown that multimedia is a very effective means to present merchandise and attract shoppers. This has been applied to the Web by including animated multimedia banner ads on web pages. However, the issues of coupling interactive browsing, shopping, and secure transactions e.g. from inside a multimedia banner, have only recently started to being explored. Currently there is an explosively growing amount of back-end services available (e.g., business to business commerce (B2B), business to consumer (B2C) commerce, and infomercial services) in the Internet. These services are mostly accessible through static HTML web pages at a few specific web portals. In this paper, we will investigate the feasibility of using interactive multimedia banners as pervasive access point for the B2C, B2B, and infomercial services. We present a system architecture that involves a layer of middleware agents functioning as the bridge between the interactive multimedia banners and back-end services.

  3. Bacteria-surface interactions.

    PubMed

    Tuson, Hannah H; Weibel, Douglas B

    2013-05-14

    The interaction of bacteria with surfaces has important implications in a range of areas, including bioenergy, biofouling, biofilm formation, and the infection of plants and animals. Many of the interactions of bacteria with surfaces produce changes in the expression of genes that influence cell morphology and behavior, including genes essential for motility and surface attachment. Despite the attention that these phenotypes have garnered, the bacterial systems used for sensing and responding to surfaces are still not well understood. An understanding of these mechanisms will guide the development of new classes of materials that inhibit and promote cell growth, and complement studies of the physiology of bacteria in contact with surfaces. Recent studies from a range of fields in science and engineering are poised to guide future investigations in this area. This review summarizes recent studies on bacteria-surface interactions, discusses mechanisms of surface sensing and consequences of cell attachment, provides an overview of surfaces that have been used in bacterial studies, and highlights unanswered questions in this field.

  4. Interactive reservoir simulation

    SciTech Connect

    Regtien, J.M.M. Por, G.J.A.; Stiphout, M.T. van; Vlugt, F.F. van der

    1995-12-31

    Shell`s new Modular Reservoir Simulator (MoReS) has been equipped with a comprehensive and versatile user interface called FrontEnd. Apart from providing a user-friendly environment for interactive reservoir simulation, FrontEnd serves a software platform for other dynamic simulation and reservoir-engineering applications. It offers to all supported applications a common user interface, enables the re-use of code and reduces overall maintenance and support costs associated with the embedded applications. Because of its features, FrontEnd facilitates the transfer of research results in the form of operational software to end users. When coupled with MoReS, FrontEnd can be used for pre- and post-processing and interactive simulation. The pre-processing options allow data to be inputted by means of various OSF/Motif widgets containing a spreadsheet, text editors, dialogues and graphical input. The display of the input data as well as the post-processing of all simulation results is made possible by a variety of user-defined plot of tabular (e.g. timestep summary) and array (simulation grid) data. During a simulation user-defined plots can be displayed and edited, allowing a close inspection of the results as they are being calculated. FrontEnd has been equipped with a powerful input command language, which gives the batch user as much flexibility and control over the input as the interactive user.

  5. Pharmacological interactions of vasoconstrictors.

    PubMed

    Gómez-Moreno, Gerardo; Guardia, Javier; Cutando, Antonio; Calvo-Guirado, José Luis

    2009-01-01

    This article is the first of a series on pharmacological interactions involving medicaments commonly prescribed and/or used in odontology: vasoconstrictors in local anaesthetics and anti-inflammatory and anti-microbial analgesics. The necessity for the odontologist to be aware of adverse reactions as a result of the pharmacological interactions is due to the increase in medicament consumption by the general population. There is a demographic change with greater life expectancy and patients have increased chronic health problems and therefore have increased medicament intake. The presence of adrenaline (epinephrine) and other vasoconstrictors in local odontological anaesthetics is beneficial in relation to the duration and depth of anaesthesia and reduces bleeding and systemic toxicity of the local anaesthetic. However, it might produce pharmacological interactions between the injected vasoconstrictors and the local anaesthetic and adrenergic medicament administered exogenically which the odontologist should be aware of, especially because of the risk of consequent adverse reactions. Therefore the importance of conducting a detailed clinical history of the general state of health and include all medicaments, legal as well as illegal, taken by the patient.

  6. Biomolecular Interaction Assay

    SciTech Connect

    Bruckner-Lea, Cindy J.; Brown, L; Holman, David A.; Olson, Lydia; Grate, Jay W.

    2000-12-29

    Understanding the binding interactions of complexes of multiple proteins is an important area of medical research since many biological signaling pathways involve multiple protein complexes. A number of sensor technologies have been adapted to monitoring biomolecular interactions. Acoustic wave devices such as flexural plate wave devices, surface transverse waves, and quartz crystal microbalances detect the mass increase observed upon binding of a solution biomolecule to a surface bound biomolecule. However, these devices will also respond to changes in viscosity, temperature, liquid density, and viscoelastic effects, which may confound the interpretation of observed signals. Nonspecific binding is indistinguishable from specific binding. Several techniques for refractive index sensing, such as planar wave guides and surface plasmon resonance (SPR), can also be used to observe biomolecular interactions localized at a surface. Again, nonspecific binding is indistinguishable from specific binding. In addition, the derivatized surface must be very thin and uniform to obtain adequate sensitivity and reproducibility, and the technique is not suited for monitoring large multiple protein complexes since the measurement sensitivity decreases rapidly with distance from the sensor surface. All of these techniques use planar surfaces that are difficult to prepare and characterize, and must be prepared fresh for each assay.

  7. Bacteria-surface interactions

    PubMed Central

    Tuson, Hannah H.; Weibel, Douglas B.

    2013-01-01

    The interaction of bacteria with surfaces has important implications in a range of areas, including bioenergy, biofouling, biofilm formation, and the infection of plants and animals. Many of the interactions of bacteria with surfaces produce changes in the expression of genes that influence cell morphology and behavior, including genes essential for motility and surface attachment. Despite the attention that these phenotypes have garnered, the bacterial systems used for sensing and responding to surfaces are still not well understood. An understanding of these mechanisms will guide the development of new classes of materials that inhibit and promote cell growth, and complement studies of the physiology of bacteria in contact with surfaces. Recent studies from a range of fields in science and engineering are poised to guide future investigations in this area. This review summarizes recent studies on bacteria-surface interactions, discusses mechanisms of surface sensing and consequences of cell attachment, provides an overview of surfaces that have been used in bacterial studies, and highlights unanswered questions in this field. PMID:23930134

  8. Apport de l'orientation clinique dans le diagnostic des hypertensions arterielles endocriniennes

    PubMed Central

    El Aziz, Siham; Chadli, Asma; Louda, Fatima; El Ghomari, Hassan; Farouqi, Ahmed

    2014-01-01

    L'hypertension artérielle d'origine endocrinienne représente une cause curable d'hypertension artérielle (HTA), ce qui en justifie le dépistage. Une orientation clinique est souhaitable afin de prescrire les bilans adéquats, notamment dans les pays en voie de développement. L'objectif de notre étude est décrire les aspects cliniques des patients ayant une HTA endocrinienne diagnostiquée au CHU de Casablanca. Méthodes: Il s'agit d'une étude descriptive rétrospective de 2004 à 2011, incluant tout patient ayant une HTA endocrinienne (en dehors des dysthyroïdies) admis en Endocrinologie. Les données concernant les facteurs cliniques, paracliniques et thérapeutiques ont été colligées. Au cours de la période étudiée, 53 cas d'HTA endocrinienne ont été admis, avec une age moyen au diagnostic de 39,3 ans et un sex-ratio F/H de 3,9. Trente patients (56.6%) ont un age ont un âge inférieur à 40 ans. On ne retrouve pas d'hérédité tensionelle chez 88.7% des patients. Les étiologies sont le Syndrome de cushing (41.5%), le phéochromocytome (32%), les adénomes somatotropes (15%) et les hyperaldostéronismes primaire (7.5%). L'HTA est essentiellement de grade un ou deux (69.8%), avec un retentissement cardio-vasculaire chez 11 patients (20.7%). Les patients ayant un SC avaient tous des signes cutanés spécifiques. Il s'agissait de sujets jeunes avec plusieurs facteurs de risque cardiovasculaire. Nous avons retrouvé un amaigrissement chez 37.5% des patients ayant un phéochromocytome avec un indice de masse corporel moyen de 20 kg/m2. L'HTA était permanente dans 5 cas de phéochromocytomes. Il n'existait pas d'hypokaliémie chez 50% des patients ayant un hyperaldostéronisme. Les signes cliniques des patients ayant une acromégalie étaient francs, avec un age moyen plus élevé de 50 ans. Nous avons noté une régression de l'HTA chez 59% de ces patients après guérison de l'endocrinopathie en cause. Plusieurs signes cliniques peuvent nous

  9. Evaluation de la tenue du partogramme dans une maternité universitaire

    PubMed Central

    Limam, Manel; Zedini, Chekib; El Ghardallou, Meriem; Mellouli, Menel; Bougmiza, Iheb; Sahli, Jihène; Khairi, Hédi; Mtiraoui, Ali; Ajmi, Thouraya Nabli

    2015-01-01

    Introduction La mortalité maternelle est un problème majeur de santé mondiale. Une grande proportion de ces décès serait évitable par des soins adéquats, une aide à l'accouchement, la disponibilité des soins d'urgence et l'utilisation des outils d'aide à la décision tels que le partogramme. L'objectif était d’évaluer l’écart entre ce qui est censé être fait et ce qui est fait réellement pour les différents paramètres situés dans le partogramme au sein d'une maternité de 3ème niveau et élaborer des recommandations pour la mise en place d'un plan d'action. Méthodes Il s'agit d'une étude descriptive rétrospective par audit clinique, effectuée sur un échantillon de 400 dossiers obstétricaux des parturientes ayant accouchées dans la maternité du CHU Farhat Hached durant l'année 2011. Le référentiel utilisé est celui réalisé par l'Agence Nationale d'Accréditation et d'Evaluation en Santé en l'an 2000, concernant la qualité de la tenue du partogramme. Résultats La majorité des critères d’évaluation portant sur la présentation du partogramme était conforme. Deux critères concernant la variété de la présentation et le rythme cardiaque fœtal étaient non conformes parmi ceux portant sur la surveillance du fœtus. Plusieurs critères en rapport avec la surveillance de la mère étaient non conformes. Aucun des critères portant sur les traitements administrés et les marqueurs d’évènements n'est conforme. Les critères portant sur la naissance et la surveillance immédiate qui étaient non conformes sont: le début des efforts expulsifs, le mode d'accouchement, l’état du périnée, la délivrance et la révision utérine. Conclusion La véritable démarche de l'audit clinique se doit d'aller au-delà du recueil et de l'analyse des données, le but final étant l'amélioration des pratiques. PMID:26516400

  10. Dommage radiatif dans l'arseniure de gallium implante a haute energie

    NASA Astrophysics Data System (ADS)

    Trudeau, Yves B.

    1999-12-01

    Voici une étude des propriétés structurales et optiques de cristaux de GaAs semi-isolant implantés à haute énergie. Un éventail de doses de 1012 à 1015 ions.cm-2 de Be à 2,3 MeV, de Si à 7 MeV et de Se à 10,9 MeV ont servi à produire des couches dopées enfouies à plus de 3 m m sous la surface. Les échantillons non recuits ont été analysés pour en tirer le profil des centres diffuseurs par canalisation ionique, le changement du paramètre de maille par diffraction de rayons x et un profil de dommage par la diffusion Raman. Le dommage résiduel a été mesuré après le recuit par canalisation, de même que, pour certains implants de Be et de Se, la distribution en profondeur de la photoluminescence et la densité des porteurs libres par diffusion Raman. À l'exception de la déformation tétragonale qui sature à forte dose, les mesures indiquent toujours un maximum de dommage près de 3 m m et les échantillons les plus endommagés présentent au moins deux sortes de dommage cristallin, en plus des défauts précurseurs présents pendant l'irradiation. Une fois recuit la qualité de la structure cristalline est retrouvée, sauf dans une région étroite ( ~ 1 m m) près de la fin du parcours des ions qui contient des défauts résiduels qui entravent les processus luminescents. Le rôle du recuit dynamique est très grand à haute énergie et uniquement les cascades les plus importantes, celles de Se, peuvent prétendre produire des défauts par un processus hétérogène. La déformation en surface peut être corrêlée au nombre de défauts calculés par simulation numérique des cascades, mais pour d'autres profondeurs ni le nombre de centres diffuseurs ni la déformation ne dépendent que de la valeur calculée pour cet endroit. La forme des profils mesurés ne s'explique qu'en supposant que l'efficacité du recuit dynamique varie fortement en fonction de la profondeur ou que les défauts créés diffusent à contre-courant pendant l

  11. DAN measures water in the soil of the Gale crater: new results from Curiosity

    NASA Astrophysics Data System (ADS)

    Mitrofanov, Igor; Litvak, Maxim; Sanin, Anton; Starr, Richard; Lisov, Denis; Kuzmin, Ruslan; Behar, Alberto; Boynton, William; Hardgrove, Craig; Harshman, Karl; Jun, Ionsoo; Miliken, Ralf; Mischna, Michael; Moersch, Jeffry; Tate, Criss

    2014-05-01

    The Gale crater was selected as the landing site for NASA's rover Curiosity (1). Since the landing in the August 2012, the neutron active instrument DAN (2) is performing active testing measurements of ground water and chlorine content along the traverse of the rover. The best model for the water content in the subsurface was found to be the 2-layer one, with the traverse-averaged contents of water in the top and bottom layers 1.51±0.42 wt% and 2.97±1.16 wt%, respectively. The traverse-average thickness of the top layer is about 18.5±8.0 cm, and the traverse-average content of chlorine is about 1.14±0.25 wt%. The uncertainties of the values above represent the physical dispersion of measurements along the traverse, while the uncertainties of individual measurements are much smaller for each tested spot. These values are not consistent with the predictions for the ground water and chlorine in the Gale, which were based on the orbital measurements by GRS suite onboard Mars Odyssey (3). The average content of water around Gale, provided it is depth independent, was found to be about 5 wt%. More accurate estimations based on 2-layer model provide even much more water in the subsurface. The content of chlorine was determined from the orbit, about 0.5 wt%. The difference between water content estimations based on the orbital and surface data are larger than the statistical uncertainty, and one cannot explain the difference by different depth of neutron sensing by DAN and GRS. Therefore, one should consider the physical reason for depletion of ground water and enhancement of chlorine in Gale in comparison with the content in the soil of the surrounding area. The Gale was not the natural site of soil hydratation, the soil around the crater has the water at higher content. During the epoch of wet Mars, the transport of soil by creeks and rivers into the Gale lake was probably associated with some selection process, which predominantly supply particles with larger sizes

  12. Allier théorie et pratique dans la lutte contre la pandémie du Sida

    PubMed Central

    Zerbo, Roger

    2014-01-01

    Le premier cas d'infection par le VIH a été notifié en 1986 au Burkina Faso. L'ignorance qui entourait cette infection et l'absence de traitement curatif a amplifié ses conséquences sociales et économiques. La mise en œuvre des interventions communautaire est un enjeu majeur actuel qui recommande la compréhension des logiques sociales endogènes qui influencent les comportements individuels et collectifs. C'est en cela que l'implication des sciences sociales dans la lutte contre les maladies, en particulier le Sida constitue un enjeu, en termes de définition et d'identification de leur contribution. Dans notre propos, nous pouvons mettre en évidence trois niveaux de contribution des sciences sociales, notamment la sociologie, l'anthropologie, la psychologie et dans une certaine mesure le droit et l’économie, à la prévention du Sida et la prise en charge des personnes infectées par le VIH. Il faut noter que ces disciplines contribuent à la lutte contre le VIH d'une part, par des réflexions et des éléments d'analyses constructives, et d'autre part, l'aptitude des porteurs de ces disciplines est parfois sollicitée pour l'efficacité de la mise en œuvre des actions et l'organisation des systèmes de soins. PMID:25722761

  13. Surpoids et obésité dans la population au-dessus de 20 ans en milieu urbain bamakois (Mali)

    PubMed Central

    Oumar Bâ, Hamidou; Menta, Ichaka; Camara, Youssouf; Sangaré, Ibrahima; Sidibé, Noumou; Doumbia, Seydou; Diarra, Mamadou Bocary

    2014-01-01

    Introduction Il est question dans notre travail d’étudier le SP et l'OB et les facteurs associés dans la population âgée de 20 ans ou plus. Méthodes Notre échantillon a été obtenu à partir d'une enquête sur les pathologies cardiovasculaires dans le District de Bamako et impliquant 2199 sujets de 5-104 ans, en sélectionnant tous les sujets âgés d'au moins 20 ans (1162). Pour chaque sujet, l'IMC, rapport taille / hanche et le tour de taille ont été déterminées. Les données ont été analysées avec SPSS 12. Résultats L’âge moyen était de 36,86 années, 61,4% étaient des femmes, 49,7% dans le secteur informel et 38,0% avaient réalisé l'enseignement primaire. Facteurs de risque cardiovasculaires étaient l'inactivité physique (72,4%), le tabagisme (12,2%) et hypertension (26,7%). La prévalence de l'obésité était de 8,8 et 14,7% respectivement sur la base de l'indice de masse et le tour de taille. Conclusion Le SP et l'OB sont à prendre en compte dans les mesures de politique sanitaire que dans la pratique quotidienne des professionnels de santé, il est peut-être plus utile d'utiliser plusieurs paramètres pour être à même de bien stratifier nos patients par rapport à leur risque. PMID:25932065

  14. Perception de l'allaitement maternel et de la diversification alimentaire dans une zone urbaine congolaise

    PubMed Central

    Kanteng, Gray A Wakamb; Lubala, Toni Kasole; Mutombo, Augustin Mulangu; Mutoke, Gayllord Nkashama; Kasongo, Aubin Ndjadi; Wembonyama, Stanis Okitotsho; Luboya, Oscar Numbi

    2014-01-01

    Introduction Les habitudes d'allaitement et de diversification alimentaire sont sensiblement influencées par la perception des mères allaitantes. L'objectif de ce travail est d’évaluer la perception de ces femmes en milieu urbain à Lubumbashi (RD Congo) afin de relever les barrières à la conduite d'un allaitement optimal. Méthodes Une étude qualitative transversale a été menée, basée sur des groupes de discussion menées dans 3 centres urbains de la ville de Lubumbashi, et concernant 76 mères avec leurs nourrissons. Résultats Sur 76 mères, 52 n'ont pas pratiqué un allaitement maternel exclusif avant 6 mois. Les principales raisons évoquées sont: le bébé pleurait beaucoup (ne se rassasie pas), le bébé ne prenait pas suffisamment de poids, la production lactée insuffisante, le manque de temps, une interdiction médicale, des raisons de pudeur ou d'esthétique corporelle. Les personnes ayant conseillé le choix ou le moment de la diversification sont: la mère elle-même, un membre de la famille, un ami, le conjoint. Conclusion La promotion d'un programme de santé visant à améliorer la perception des mères sur la pratique de l'allaitement maternel et de la diversification est un axe important pour améliorer le taux d'allaitement maternel exclusif avant 6 mois. PMID:25918576

  15. La plastie en rail dans le traitement des brides rétractiles du creux poplite

    PubMed Central

    Achbouk, A.; Khales, A.; Bourra, K.; Tourabi, K.; Ababou, K.; Ihrai, H.

    2011-01-01

    Summary Les Auteurs décrivent le cas d’un patient âgé de 45 ans atteint de brûlures thermiques par flammes suite à la déflagration d’une bonbonne de gaz. Les lésions initiales intéressaient les quatre membres (en particulier, le genou) et le tronc. La prise en charge initiale a consisté en une excision-greffe précoce des membres. L’évolution a été marquée par la survenue de cicatrices hypertrophiques au niveau des zones non greffées et à la bordure de la greffe ainsi que la survenue de brides rétractiles. Devant l’handicap fonctionnel engendré par la bride à cause de la limitation importante de l’extension, le patient a été admis pour cure chirurgicale. Grâce à la technique en rail décrite, le patient a pu récupérer une fonction normale du genou. Les suites ont été simples avec une durée d’hospitalisation d’un mois. Le résultat esthétique est relativement satisfaisant. La technique en rail est un moyen parmi l’arsenal thérapeutique qui permet de traiter la bride du creux poplité. Sa simplicité, sa facilité technique et son résultat satisfaisant ainsi que ses suites simples permettent de la rendre une technique très prisée dans le traitement de ce type de bride. PMID:21991240

  16. Stabilisation des phases monocristallines quadratique et cubique dans BaTiO3

    NASA Astrophysics Data System (ADS)

    Amami, J.; Goutaudier, C.; Trabelsi-Ayadi, M.; Boulon, G.

    2004-12-01

    Single crystals of Ba1-xYbxTiO3 and Ba1-xSrxTiO3 with tetragonal structure were grown by the floating zone (FZ) method using an LHPG (Laser Heated Pedestal Growth) technique. The grown crystals, typically 1 mm in diameter and 8 mm in length, were yellowish transparent. Substitution of more than 2.5 at % Sr for Ba in BaTiO3 and addition of 3 to 5 at % Ln (Ln= Yb, Eu), were effective in preventing the formation of the hexagonal phase. The Eu3+ emission spectra recorded at room temperature demonstrate a significant intensity enhancement of the 5D0 → 7F1 magnetic dipolar transition compared to the 5D0 → 7F2 electric dipolar transition. Les fibres monocristallines de Ba1-xYbxTiO3 et Ba1-xSrxTiO3 de structure quadratique ont été préparées par la méthode de la zone flottante (FZ) en utilisant la technique LHPG (Laser Heated Pedestal Growth). Les échantillons élaborés, de dimensions 1mm x 8 mm, sont jaunâtres et transparentes. La substitution du baryum par plus de 2,5 mol% de Sr dans BaTiO3 et le dopage de 3 à 5 mol% de Ln (Ln = Yb, Eu) évitent la formation de la phase hexagonale. Le spectre d’émission de Eu3+ enregistré à température ambiante montre le changement de structure traduit par la forte intensité de la transition dipolaire magnétique 5D0 → 7F1 comparée à celle de la transition dipolaire électrique 5D0 → 7F2.

  17. Open air refuse burning video: Proton Dan the science man explores open air refuse burning

    SciTech Connect

    Eastburn, M.D.; Sipple, J.L.; Deramo, A.R.

    1999-07-01

    The goal of this video is to educate school children to the potential hazards of open air trash burning; to demonstrate alternative ways to dispose of trash; and to motivate students to take action to change the behavior of their parents with regard to trash burning. The burning of household trash, although illegal, is still a common practice in rural areas of Delaware. Enforcement has been difficult because the practice is often performed at night and is done across a wide rural area that is difficult to patrol on a continuing basis. The prohibition on trash burning (revised Regulation 13 of The Delaware Code of Regulations Governing The Control of Air Pollution) has been in effect since 1968, but the public has been slow to comply because trash burning has been practiced for many generations and because much of the public is unaware of the environmental impacts and/or the human health risks. This video may be valuable for other States to use as a public outreach tool regarding their problems with open air refuse burning. The focus of the video is a 7th grade science class is given various assignments relating to Earth Day and preservation of natural resources. Two children in particular are given the assignment to research and report on the hazards of open air trash burning and are asked to investigate alternative ways to dispose of refuse. Upon brainstorming how to find information on the topic, the kids decide to contact the host of a popular children's science show on broadcast television named Proton Dan the Science Man (a fictitious character and show based on Bill Nye the Science Guy). The host then invites the kids to the studio where he films his show and takes them through the topic. The TV host character takes the children to several external locations like a landfill, recycling centers, etc..

  18. Oncoplastie avec conservation mammaire dans le traitement du cancer du sein: à propos de 16 cas

    PubMed Central

    Bouzoubaa, Wail; Laadioui, Meryam; Jayi, Sofia; Alaoui, Fatime Zahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2015-01-01

    Le cancer du sein est actuellement le cancer le plus fréquent chez la femme, et pose un véritable problème diagnostique et thérapeutique. Le dépistage des lésions à un stade de plus en plus précoce, a permis une extension des indications du traitement conservateur radiochirurgical, qui était initialement limitées aux tumeurs de moins de 3 cm, unifocales, non inflammatoires. Par ailleurs, l'utilisation de traitements préopératoires permet d’étendre les indications du traitement conservateur à des tumeurs plus volumineuses. Parallèlement à cette extension des indications de conservation mammaire, on a observé le développement de nouvelles approches thérapeutiques notamment la chirurgie oncoplastique, technique du ganglion sentinelle et chirurgie stéréotaxique, dont les résultats initiaux sont très encouragent. A travers cette étude réalisée dans le service de gynécologie et obstétrique II du CHU HASSAN II de FES au MAROC, après l'analyse rétrospective de 16 patientes traitées par traitement conservateur et oncoplastie, nous avons voulus montrer notre aptitude a réalisé ses techniques chirurgicales et a bien prendre en charge ces patientes, mais aussi évaluer ces techniques en termes de résultat carcinologique et de résultat esthétique, aussi en terme de survie globale, survie sans métastase et en termes de récidive locale entre les plasties mammaires et les traitements usuels: mastectomie et traitement conservateur classique. PMID:26430477

  19. La manucure et la pédicure dans la ville de Ouagadougou (Burkina Faso): pratiques et risqué

    PubMed Central

    Korsaga-Somé, Nina; Andonaba, Jean Baptiste; Ouédraogo, Muriel Sidnoma; Tapsoba, Gilbert Patrice; Ilboudo, Léopold; Savadogo, Cérina; Barro-Traoré, Fatou; Niamba, Pascal; Traoré, Adama

    2016-01-01

    La manucure-pédicure est l'ensemble des soins esthétiques des mains, des pieds et des ongles. Au Burkina Faso, l'usage des produits de manucure-pédicure, les techniques utilisées ainsi que les risques encourus restent méconnus. L'objectif de notre étude était d’évaluer la pratique de la manucure-pédicure dans la ville de Ouagadougou. Nous avons mené une étude transversale descriptive de décembre 2010 à novembre 2012 incluant tout les praticiens ayant au moins six mois d'expérience dans l'activité et les clients présents sur les lieux au moment de l'enquête. Nous avons interrogé au total 313 praticiens et 313 clients. L’âge moyen des praticiens était de 19 ans et celui des clients de 32,2 ans. Les praticiens fixes étaient en majorité des femmes (96,87%), ceux mobiles surtout des hommes (68,37%), et 64,53% des clients étaient des femmes. Le pourcentage de praticiens n'ayant pas reçu de formation professionnelle était de 93,92%. 29,7% des praticiens faisaient tremper les instruments pendant au moins dix minutes dans de l'eau de javel; 75,71% savaient que l'utilisation de certains outils étaient dangereux et 26,51% étaient avaient présenté des effets secondaires. Parmi les clients, 40,25% savaient que le matériel utilisé comportait des risques et 30,35% avaient été victimes d'accidents. Les soins de manucure et de pédicure se font dans les salons de coiffure par des coiffeuses non formées à l'exercice de la profession La provenance et la composition des produits n'est pas connues. Des produits non recommandés sont utilisés (shampooing pour trempage des pieds, lame de rasoir et ciseaux pour raclage des pieds). Le recours à la manucure et/ou pédicure est parfois nécessaire mais cela ne doit pas faire perdre de vue les risques encourus. Une sensibilisation des clients et une formation des praticiens semblent nécessaires pour minimiser les risques. PMID:27642448

  20. Utilisation de la Fibre a Deux Coeurs Non-Lineaire dans les Lasers EN Fibre et Lignes de Transmission

    NASA Astrophysics Data System (ADS)

    Essiambre, Rene-Jean

    L'utilisation des proprietes non-lineaires de la fibre optique a deux coeurs identiques constitue l'objet de cette etude numerique. Les effets non-lineaires dans les fibres optiques ainsi que la theorie des modes couples sont abordes pour decrire le comportement de la fibre a deux coeurs non-lineaire. On a d'abord analyse les proprietes de transmission d'une telle fibre autour de la puissance critique lorsqu'elle est recouplee a elle-meme dans une configuration Sagnac pour differentes valeurs de dispersion. Nous avons observe des effets simultanes de compression et de filtrage non-lineaire des impulsions injectees. On a ensuite considere configuration de laser en fibre incluant une fibre a deux coeurs comme element passif de synchronisation modale adjoint a un mileu amplificateur externe ayant une largeur de gain finie. On a demontre qu'il etait possible de generer ainsi des solitons fondamentaux de puissance variable et ce, avec tres peu d'ondes dispersives. Ces solitons possedent un spectre qui est de l'ordre de grandeur de la largeur du milieu de gain du laser et ils ne sont amplifies que faiblement a chaque passage. La combinaison d'une fibre a deux coeurs et d'un milieu de gain de largeur de bande finie peut egalement etre utilisee pour controler certains effets non-lineaires d'ordre superieur comme l'auto -glissement en frequence du soliton (diffusion Raman intra -impulsion) qui deplace le spectre d'un soliton vers les basses frequences. Pour une certaine plage de parametres on obtient une stabilisation periodique du deplacement en frequence du soliton. La zone de stabilite correspondant a une longueur de fibre de l'ordre de quelques kilometres et a une duree de soliton d'environ deux a cinq picosecondes. Un tel dispositif semble bien adapte pour la transmission d'information par solitons sur de longues distances dans un nouveau regime d'operation. Enfin, tout au long de l'ouvrage, on retrouve des analyses reliees a des systemes deja existants et on situe les

  1. Enjeux de fin de vie dans les cas de démence avancée

    PubMed Central

    Arcand, Marcel

    2015-01-01

    Résumé Objectif Examiner les enjeux liés à l’établissement d’objectifs des soins pour les patients atteints de démence sévère, décrire les rôles respectifs du médecin et des proches du patient dans le processus de prise de décision et suggérer des façons d’appuyer les proches qui souhaitent obtenir plus d’information sur les options thérapeutiques. Sources des données Une recherche d’articles pertinents publiés avant le 7 mars 2014 a été effectuée dans MEDLINE sur Ovid. Aucune étude de niveau I n’a été relevée; la plupart des articles fournissaient des preuves de niveaux III. Message principal Pour les patients atteints de démence avancée, la famille joue un rôle important dans la prise de décisions médicales. Les proches devraient recevoir de l’information ponctuelle sur l’évolution de la démence et les options relatives aux soins. Ils doivent comprendre qu’il pourrait être approprié d’adopter une approche de soins palliatifs, ce qui ne signifie pas que le patient est abandonné à son sort. Ils pourraient aussi souhaiter clarifier leur rôle dans le processus de prise de décision, surtout lorsqu’on envisage de mettre fin aux mesures de prolongement de vie. Conclusion Les médecins doivent voir la démence avancée comme une maladie terminale pour laquelle il existe un continuum de soins qui s’étend de l’approche de soins palliatifs avec mesures acceptables de prolongement de vie à l’approche exclusivement symptomatique. Il est primordial de clarifier les objectifs des soins et d’éduquer les proches pour éviter les interventions non souhaitées et pénibles.

  2. La stimulation magnétique transcrânienne (SMT) dans la recherche fondamentale et clinique en neuroscience

    PubMed Central

    Valero-Cabré, Antoni; Pascual-Leone, Alvaro; Coubard, Olivier A.

    2011-01-01

    Introduction Les méthodes de stimulation cérébrale non invasives telles que la Stimulation Magnétique Transcrânienne (SMT) sont largement utilisées pour établir des inférences causales sur les relations entre cerveau et comportement. Des applications cliniques basées sur la SMT ont également été développées pour traiter des affections neurologiques ou psychiatriques comme la dépression, la dystonie, la douleur, les acouphènes ou les séquelles d’accident vasculaire cérébral. État des connaissances La SMT fonctionne en induisant de manière non invasive et de manière focale des courants électriques dans des régions corticales, modulant ainsi leur niveau d’activité de façon variable suivant la fréquence, le nombre d’impulsions, les intervalles et la durée de stimulation utilisés. S’agissant du cortex moteur, on sait par exemple que les patterns d’impulsions de SMT à basse fréquence ou ceux délivrées de manière continue tendent à déprimer l’activité locale, tandis que la SMT à haute fréquence et discontinus tend à la potentialiser. Outre ses effets locaux, la SMT peut aussi avoir des effets à distance sur les régions cérébrales, véhiculés par les connections anatomiques et qui dépendent de l’efficacité et du signe de ces connexions. Perspectives Dans le domaine de la recherche fondamentale et des applications thérapeutiques, l’utilisation efficace de la SMT requiert, cependant, la compréhension approfondie de ses principes opérationnels, de ses risques, de ses potentialités et de ses limites. Dans cet article, nous présentons les principes par lesquels opèrent les méthodes de stimulation cérébrale non invasive, et en particulier la SMT. Conclusion À l’issue de sa lecture, le lecteur sera en mesure de discuter de façon critique les études scientifiques et cliniques utilisant la SMT, ainsi que de concevoir des applications SMT suivant une hypothèse a priori dans le domaine de la recherche en

  3. Dermatomyosite du sujet âgé: étude de 4 observations dans le sud tunisien

    PubMed Central

    Frikha, Faten; Snoussi, Mouna; Salah, Raida Ben; Saidi, Noura; Kaddour, Neila; Bahloul, Zouhir

    2012-01-01

    La dermatomyosite (DM) touche essentiellement l’adolescent et l’adulte jeune, elle est très rare chez le sujet âgé, le plus souvent associée à des complications iatrogènes et à une pathologie cancéreuse. Nous avons étudié les caractéristiques de la DM du sujet âgé à travers une étude rétrospective dans laquelle nous avons comparé 4 patients âgés de plus de 65 ans au début de la myosite avec 40 sujets jeunes. PMID:23308331

  4. Dynamique ultra-rapide de réseaux périodiques de trous sub-longueur d'onde dans des films métalliques

    NASA Astrophysics Data System (ADS)

    Halté, V.; Benabbas, A.; Guidoni, L.; Bigot, J.-Y.

    2006-10-01

    Nous avons étudié, par spectroscopie femtoseconde, la transmission différentielle de réseaux périodiques de trous sub-longueur d'onde inscrits dans des films métalliques d'or. En particulier, nous avons montré que le comportement dynamique de la fonction diélectrique \\varepsilon du métal permet d'expliquer la dynamique spectrale des deux résonances présentes dans le spectre linéaire de nos nanostructures.

  5. Usability of Information in Battle Management Operations (1’Exploitation de l’information dans les operations de gestion du champ de bataille)

    DTIC Science & Technology

    2007-11-02

    de gestion du champ de bataille) Papers presented at the RTO Human Factors and Medicine Panel (HFM) Symposium held in Oslo, Norway, 10-13 April 2000...Information in Battle Management Operations (l’Exploitation de l’information dans les opérations de gestion du champ de bataille) Papers presented at the RTO...is easily used by battlespace managers and warfighters. iii l’Exploitation de l’information dans les opérations de gestion du champ de bataille (RTO

  6. Reconstruction de la surface de Fermi dans l'etat normal d'un supraconducteur a haute Tc: Une etude du transport electrique en champ magnetique intense

    NASA Astrophysics Data System (ADS)

    Le Boeuf, David

    Des mesures de resistance longitudinale et de resistance de Hall en champ magnetique intense transverse (perpendiculaire aux plans CuO2) ont ete effectuees au sein de monocristaux de YBa2Cu3Oy (YBCO) demacles, ordonnes et de grande purete, afin d'etudier l'etat fondamental des supraconducteurs a haute Tc dans le regime sous-dope. Cette etude a ete realisee en fonction du dopage et de l'orientation du courant d'excitation J par rapport a l'axe orthorhombique b de la structure cristalline. Les mesures en champ magnetique intense revelent par suppression de la supraconductivite des oscillations magnetiques des resistances longitudinale et de Hall dans YBa2Cu 3O6.51 et YBa2Cu4O8. La conformite du comportement de ces oscillations quantiques au formalisme de Lifshitz-Kosevich, apporte la preuve de l'existence d'une surface de Fermi fermee a caractere quasi-2D, abritant des quasiparticules coherentes respectant la statistique de Fermi-Dirac, dans la phase pseudogap d'YBCO. La faible frequence des oscillations quantiques, combinee avec l'etude de la partie monotone de la resistance de Hall en fonction de la temperature indique que la surface de Fermi d'YBCO sous-dope comprend une petite poche de Fermi occupee par des porteurs de charge negative. Cette particularite de la surface de Fermi dans le regime sous-dope incompatible avec les calculs de structure de bande est en fort contraste avec la structure electronique presente dans le regime surdope. Cette observation implique ainsi l'existence d'un point critique quantique dans le diagramme de phase d'YBCO, au voisinage duquel la surface de Fermi doit subir une reconstruction induite par l'etablissement d'une brisure de la symetrie de translation du reseau cristallin sous-jacent. Enfin, l'etude en fonction du dopage de la resistance de Hall et de la resistance longitudinale en champ magnetique intense suggere qu'un ordre du type onde de densite (DW) est responsable de la reconstruction de la surface de Fermi. L'analogie de

  7. Strategies to Address Recruiting and Retention Issues in the Military (Strategies pour aborder les questions de recrutement et de fidelisation dans les armees)

    DTIC Science & Technology

    2009-10-01

    Oct 2009 Strategies to Address Recruiting and Retention Issues in the Military (Stratégies pour aborder les questions de recrutement et de...les questions de recrutement et de fidélisation dans les armées) The material in this publication was assembled to support a Special Course under...HFM-180 Stratégies pour aborder les questions de recrutement et de fidélisation dans les armées (RTO-EN-HFM-180) Synthèse L’objectif des

  8. Weakly nonlinear magnetohydrodynamic wave interactions

    SciTech Connect

    Webb, G.M.; Brio, M.; Kruse, M.T.; Zank, G.P.

    1999-06-01

    Equations describing weakly nonlinear magnetohydrodynamic (MHD) wave interactions in one Cartesian space dimension are discussed. For wave propagation in uniform media, the wave interactions of interest consist of: (a) three-wave resonant interactions in which high frequency waves, may evolve on long space and time scales if the wave phases satisfy the resonance conditions; (b) Burgers self-wave steepening for the magnetoacoustic waves, and (c) mean wave field effects, in which a particular wave interacts with the mean wave field of the other waves. For wave propagation in non-uniform media, further linear wave mixing terms appear in the equations. The equations describe four types of resonant triads: slow-fast magnetosonic wave interaction; Alfv{acute e}n-entropy wave interaction; Alfv{acute e}n-magnetosonic wave interaction; and magnetosonic-entropy wave interaction. The formalism is restricted to coherent wave interactions. {copyright} {ital 1999 American Institute of Physics.}

  9. New approximate orientation averaging of the water molecule interacting with the thermal neutron

    SciTech Connect

    Markovic, M.I.; Minic, D.M.; Rakic, A.D. . Elektrotehnicki Fakultet)

    1992-02-01

    This paper reports that exactly describing the time of thermal neutron collisions with water molecules, orientation averaging is performed by an exact method (EOA{sub k}) and four approximate methods (two well known and two less known). Expressions for the microscopic scattering kernel are developed. The two well-known approximate orientation averaging methods are Krieger-Nelkin (K-N) and Koppel-Young (K-Y). The results obtained by one of the two proposed approximate orientation averaging methods agree best with the corresponding results obtained by EOA{sub k}. The largest discrepancies between the EOA{sub k} results and the results of the approximate methods are obtained using the well-know K-N approximate orientation averaging method.

  10. Very-High-Energy Solar Gamma Rays From Cosmic-Ray Interactions

    NASA Astrophysics Data System (ADS)

    Zhou, Bei; Ng, Kenny; Beacom, John; Peter, Annika; Rott, Cartsen

    2017-01-01

    Cosmic-ray induced gamma rays from the Sun has been observed up to 100 GeV. However, there are no theoretical predictions beyond 10 GeV. We provide the first calculation of the hadronic disk component in TeV-PeV, where solar magnetic fields can be ignored. We also consider the leptonic gamma-ray halo, taking into account electrons from local pulsars. With Fermi and soon HAWC & LHAASO observations, our results provide new insights on local cosmic rays, solar magnetic fields, and solar dark matter studies. BZ is supported by OSU Fowler Fellowship. KN and FB are supported by NSF Grant PHY-1404311. AK is supported by NSF GRFP Grant No. DGE-1321846. CR is supported by the Korea Neutrino Research Center. KN is also supported by the OSU Presidential Fellowship.

  11. Interactive Learning and "Clickers"

    NASA Astrophysics Data System (ADS)

    Rudolph, Alexander

    2006-12-01

    A growing body of evidence demonstrates that student understanding and retention of key concepts in science can be dramatically improved by using “Interactive Learning” techniques. Interactive learning is a way to get students more actively involved in their own learning than by simple lecture alone. I will focus on one type of interactive learning activity, known as “Think-Pair-Share”. After a brief (10-20 minute) lecture on a topic, students are asked a conceptually challenging multiple-choice question. After they answer, if there is sufficient disagreement, the students discuss the question in small groups after which they answer the same question again. Frequently, the percentage of correct answers goes up, indicating that the active role of speaking and listening, together with peer instruction, has helped students better grasp the concept being tested. If disagreement persists, or if students continue to have questions, a short, class-wide discussion can be held. Clickers provide an excellent means to collect students’ answers to “Think-Pair-Share” questions in real time. Although clickers are not essential, they do provide some advantages over alternatives such as flash cards: answers are completely anonymous (though you as instructor can record individual responses); you can display a histogram of results immediately, either before or after group discussion, providing immediate feedback; by recording the results, you can give students credit for their participation in class. In this talk, I will model “Think-Pair-Share” with the audience using clickers, show results from my classes before and after group discussions, share results of a student survey on “Think-Pair-Share” and clickers, describe other uses of clickers (e.g., taking attendance, surveys, test administration) and highlight some of the pros and cons of clickers v. flashcards.

  12. Intelligently interactive combat simulation

    NASA Astrophysics Data System (ADS)

    Fogel, Lawrence J.; Porto, Vincent W.; Alexander, Steven M.

    2001-09-01

    To be fully effective, combat simulation must include an intelligently interactive enemy... one that can be calibrated. But human operated combat simulations are uncalibratable, for we learn during the engagement, there's no average enemy, and we cannot replicate their culture/personality. Rule-based combat simulations (expert systems) are not interactive. They do not take advantage of unexpected mistakes, learn, innovate, and reflect the changing mission/situation. And it is presumed that the enemy does not have a copy of the rules, that the available experts are good enough, that they know why they did what they did, that their combat experience provides a sufficient sample and that we know how to combine the rules offered by differing experts. Indeed, expert systems become increasingly complex, costly to develop, and brittle. They have face validity but may be misleading. In contrast, intelligently interactive combat simulation is purpose- driven. Each player is given a well-defined mission, reference to the available weapons/platforms, their dynamics, and the sensed environment. Optimal tactics are discovered online and in real-time by simulating phenotypic evolution in fast time. The initial behaviors are generated randomly or include hints. The process then learns without instruction. The Valuated State Space Approach provides a convenient way to represent any purpose/mission. Evolutionary programming searches the domain of possible tactics in a highly efficient manner. Coupled together, these provide a basis for cruise missile mission planning, and for driving tank warfare simulation. This approach is now being explored to benefit Air Force simulations by a shell that can enhance the original simulation.

  13. Visuo-Vestibular Interactions

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Session TA3 includes short reports covering: (1) Vestibulo-Oculomotor Interaction in Long-Term Microgravity; (2) Effects of Weightlessness on the Spatial Orientation of Visually Induced Eye Movements; (3) Adaptive Modification of the Three-Dimensional Vestibulo-Ocular Reflex during Prolonged Microgravity; (4) The Dynamic Change of Brain Potential Related to Selective Attention to Visual Signals from Left and Right Visual Fields; (5) Locomotor Errors Caused by Vestibular Suppression; and (6) A Novel, Image-Based Technique for Three-Dimensional Eye Measurement.

  14. Interactive Classification Technology

    NASA Technical Reports Server (NTRS)

    deBessonet, Cary

    2000-01-01

    The investigators upgraded a knowledge representation language called SL (Symbolic Language) and an automated reasoning system called SMS (Symbolic Manipulation System) to enable the more effective use of the technologies in automated reasoning and interactive classification systems. The overall goals of the project were: 1) the enhancement of the representation language SL to accommodate a wider range of meaning; 2) the development of a default inference scheme to operate over SL notation as it is encoded; and 3) the development of an interpreter for SL that would handle representations of some basic cognitive acts and perspectives.

  15. Human Computer Interaction

    NASA Astrophysics Data System (ADS)

    Bhagwani, Akhilesh; Sengar, Chitransh; Talwaniper, Jyotsna; Sharma, Shaan

    2012-08-01

    The paper basically deals with the study of HCI (Human computer interaction) or BCI(Brain-Computer-Interfaces) Technology that can be used for capturing brain signals and translating them into commands that allow humans to control (just by thinking) devices such as computers, robots, rehabilitation technology and virtual reality environments. The HCI is based as a direct communication pathway between the brain and an external device. BCIs are often aimed at assisting, augmenting, or repairing human cognitive or sensory-motor functions.The paper also deals with many advantages of BCI Technology along with some of its applications and some major drawbacks.

  16. Detection of molecular interactions

    DOEpatents

    Groves, John T [Berkeley, CA; Baksh, Michael M [Fremont, CA; Jaros, Michal [Brno, CH

    2012-02-14

    A method and assay are described for measuring the interaction between a ligand and an analyte. The assay can include a suspension of colloidal particles that are associated with a ligand of interest. The colloidal particles are maintained in the suspension at or near a phase transition state from a condensed phase to a dispersed phase. An analyte to be tested is then added to the suspension. If the analyte binds to the ligand, a phase change occurs to indicate that the binding was successful.

  17. Flank solar wind interaction

    NASA Technical Reports Server (NTRS)

    Moses, Stewart L.; Greenstadt, Eugene W.

    1992-01-01

    This report summarizes the results of the first 12 months of our program to study the interaction of the Earth's magnetosphere with the solar wind on the far flanks of the bow shock. This study employs data from the ISEE-3 spacecraft during its traversals of the Earth's magnetotail and correlative data from spacecraft monitoring the solar wind upstream. Our main effort to date has involved assembling data sets and developing new plotting programs. Two talks were given at the Spring Meeting of the American Geophysical Union describing our initial results from analyzing data from the far flank foreshock and magnetosheath. The following sections summarize our results.

  18. Integrin Cytoplasmic Tail Interactions

    PubMed Central

    2015-01-01

    Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life. They connect cells to the extracellular environment and transduce chemical and mechanical signals to and from the cell. Intracellular proteins that bind the integrin cytoplasmic tail regulate integrin engagement of extracellular ligands as well as integrin localization and trafficking. Cytoplasmic integrin-binding proteins also function downstream of integrins, mediating links to the cytoskeleton and to signaling cascades that impact cell motility, growth, and survival. Here, we review key integrin-interacting proteins and their roles in regulating integrin activity, localization, and signaling. PMID:24467163

  19. Bunyavirus-Vector Interactions

    PubMed Central

    Horne, Kate McElroy; Vanlandingham, Dana L.

    2014-01-01

    The Bunyaviridae family is comprised of more than 350 viruses, of which many within the Hantavirus, Orthobunyavirus, Nairovirus, Tospovirus, and Phlebovirus genera are significant human or agricultural pathogens. The viruses within the Orthobunyavirus, Nairovirus, and Phlebovirus genera are transmitted by hematophagous arthropods, such as mosquitoes, midges, flies, and ticks, and their associated arthropods not only serve as vectors but also as virus reservoirs in many cases. This review presents an overview of several important emerging or re-emerging bunyaviruses and describes what is known about bunyavirus-vector interactions based on epidemiological, ultrastructural, and genetic studies of members of this virus family. PMID:25402172

  20. Imitation, Interaction and Dialogue Using Intensive Interaction: Tea Party Rules

    ERIC Educational Resources Information Center

    Barber, Mark

    2007-01-01

    Intensive Interaction has become widely used when building up communication with children with profound learning difficulties. Often practitioners understand Intensive Interaction to be primarily about imitation and Mark Barber shows how this can be a "mis"understanding that limits the kinds of interactions that can be enjoyed by conversation…

  1. KKN molecule state with I=1/2 and J{sup P}=1/2{sup +} studied with a three-body calculation

    SciTech Connect

    Jido, Daisuke; Kanada-En'yo, Yoshiko

    2008-09-15

    A KKN system with I=1/2 and J{sup P}=1/2{sup +} is investigated with nonrelativistic three-body calculations by using effective KN,KK, and KN interactions. The KN interaction describes the {lambda}(1405) as a KN molecule, and the KK interaction is adjusted to give f{sub 0}(980) and a{sub 0}(980) states as KK molecules. The present investigation suggests that a bound KKN state can be formed below the KKN threshold (1930 MeV) with a 90{approx}100 MeV width of three-hadron decays, which are dominated by KKN{yields}K{pi}{sigma} and {pi}{eta}N. The KKN state is found to be a weakly bound hadron molecular state with a size larger than an {alpha} particle because of the repulsive KN interactions.

  2. Syndrome métabolique chez les patients hypertendus dans le service cardiologie du CHU Yalgado Ouedraogo de Ouagadougou, Burkina Faso

    PubMed Central

    Millogo, Georges Rosario Christian; Samandoulougou, André; Yaméogo, Nobila Valentin; Yaméogo, Aristide Relwendé; Kologo, Koudougou Jonas; Toguyeni, Jean Yves; Zabsonré, Patrice

    2014-01-01

    Introduction Le syndrome métabolique constitue de nos jours un véritable problème de santé publique. Le syndrome métabolique est le moteur d'une double épidémie mondiale de diabète type II et de maladies cardiovasculaires. L'objectif de notre étude est de décrire les aspects épidémiologiques, cliniques, para cliniques et évolutifs chez les hypertendus dans le service de Cardiologie du CHU Yalgado Ouédraogo. Méthodes Il s'agissait d'une étude rétrospective sur une période de deux ans dans le service de cardiologie chez les patients hypertendus ayant un syndrome métabolique. Résultats La fréquence du syndrome métabolique était de 17,5% des patients hypertendus. Le sex ratio était de 1,2. L’âge moyen des patients étaient de 56,1 ±10,7 ans. Les patients connus hypertendus étaient de 92,1% avec une durée moyenne d’évolution de l'HTA qui était de 8,7 ± 5,9 ans. Le suivi était irrégulier dans 60% cas et une rupture du traitement dans 37,1% des cas. La dyslipidémie était notée dans 84,2% des cas et le diabète dans 60,5% des cas. La PAS moyenne était de 184,3 ± 47,3 mmHg et la PAD moyenne était de 110,7 ± 27,7 mmHg. L'HTA était sévère dans 63,2% des cas. La glycémie moyenne était de 8,3 ± 4,3 mmol/L, le LDL cholestérol moyen était de 3,5 ± 1,0 mmol/L et le taux des triglycérides moyen était de 1,6 ± 1,1 mmol/L. L'HVG électrique était notée chez 76,3% des patients et échographique dans 58,8% des cas. Les atteintes viscérales étaient neurologique dans 44,5%, rénale dans 55,3% et cardiaque dans 31,2% des cas. Le nombre moyen d'antihypertenseurs était de 3,0 ± 1,0 et 76,3% ont reçu au moins une trithérapie antihypertensive. Le taux de mortalité était de 5,3%. Conclusion Le syndrome métabolique est une pathologie qui pose la problématique de la définition qui n'est pas consensuelle d'une part et d'autre part du contrôle de ses éléments constitutifs surtout l'HTA. PMID:25883718

  3. JSPAM: Interacting galaxies modeller

    NASA Astrophysics Data System (ADS)

    Wallin, John F.; Holincheck, Anthony; Harvey, Allen

    2015-11-01

    JSPAM models galaxy collisions using a restricted n-body approach to speed up computation. Instead of using a softened point-mass potential, the software supports a modified version of the three component potential created by Hernquist (1994, ApJS 86, 389). Although spherically symmetric gravitationally potentials and a Gaussian model for the bulge are used to increase computational efficiency, the potential mimics that of a fully consistent n-body model of a galaxy. Dynamical friction has been implemented in the code to improve the accuracy of close approaches between galaxies. Simulations using this code using thousands of particles over the typical interaction times of a galaxy interaction take a few seconds on modern desktop workstations, making it ideal for rapidly prototyping the dynamics of colliding galaxies. Extensive testing of the code has shown that it produces nearly identical tidal features to those from hierarchical tree codes such as Gadget but using a fraction of the computational resources. This code was used in the Galaxy Zoo: Mergers project and is very well suited for automated fitting of galaxy mergers with automated pattern fitting approaches such as genetic algorithms. Java and Fortran versions of the code are available.

  4. Incremental full configuration interaction

    NASA Astrophysics Data System (ADS)

    Zimmerman, Paul M.

    2017-03-01

    The incremental expansion provides a polynomial scaling method for computing electronic correlation energies. This article details a new algorithm and implementation for the incremental expansion of full configuration interaction (FCI), called iFCI. By dividing the problem into n-body interaction terms, accurate correlation energies can be recovered at low n in a highly parallel computation. Additionally, relatively low-cost approximations are possible in iFCI by solving for each incremental energy to within a specified threshold. Herein, systematic tests show that FCI-quality energies can be asymptotically reached for cases where dynamic correlation is dominant as well as where static correlation is vital. To further reduce computational costs and allow iFCI to reach larger systems, a select-CI approach (heat-bath CI) requiring two parameters is incorporated. Finally, iFCI provides the first estimate of FCI energies for hexatriene with a polarized double zeta basis set, which has 32 electrons correlated in 118 orbitals, corresponding to a FCI dimension of over 1038.

  5. Interactive Computer Graphics

    NASA Technical Reports Server (NTRS)

    Kenwright, David

    2000-01-01

    Aerospace data analysis tools that significantly reduce the time and effort needed to analyze large-scale computational fluid dynamics simulations have emerged this year. The current approach for most postprocessing and visualization work is to explore the 3D flow simulations with one of a dozen or so interactive tools. While effective for analyzing small data sets, this approach becomes extremely time consuming when working with data sets larger than one gigabyte. An active area of research this year has been the development of data mining tools that automatically search through gigabyte data sets and extract the salient features with little or no human intervention. With these so-called feature extraction tools, engineers are spared the tedious task of manually exploring huge amounts of data to find the important flow phenomena. The software tools identify features such as vortex cores, shocks, separation and attachment lines, recirculation bubbles, and boundary layers. Some of these features can be extracted in a few seconds; others take minutes to hours on extremely large data sets. The analysis can be performed off-line in a batch process, either during or following the supercomputer simulations. These computations have to be performed only once, because the feature extraction programs search the entire data set and find every occurrence of the phenomena being sought. Because the important questions about the data are being answered automatically, interactivity is less critical than it is with traditional approaches.

  6. Interactive Terascale Particle Visualization

    NASA Technical Reports Server (NTRS)

    Ellsworth, David; Green, Bryan; Moran, Patrick

    2004-01-01

    This paper describes the methods used to produce an interactive visualization of a 2 TB computational fluid dynamics (CFD) data set using particle tracing (streaklines). We use the method introduced by Bruckschen et al. [2001] that pre-computes a large number of particles, stores them on disk using a space-filling curve ordering that minimizes seeks, and then retrieves and displays the particles according to the user's command. We describe how the particle computation can be performed using a PC cluster, how the algorithm can be adapted to work with a multi-block curvilinear mesh, and how the out-of-core visualization can be scaled to 296 billion particles while still achieving interactive performance on PG hardware. Compared to the earlier work, our data set size and total number of particles are an order of magnitude larger. We also describe a new compression technique that allows the lossless compression of the particles by 41% and speeds the particle retrieval by about 30%.

  7. Pharmacokinetic interactions with rifampicin.

    PubMed

    Zilly, W; Breimer, D D; Richter, E

    1977-01-01

    Rifampicin, a potent antituberculosis agent, is frequently combined with other antituberculosis drugs, or with drugs belonging to entirely different classes which may be required during a long period of antituberculous treatment, and therefore has a potential for drug interactions of practical clinical importance. The absorption of rifampicin is markedly decreased when it is simultaneously administered with para-aminosalicylic acid granules, due to adsorption by an excipient, bentonite. Several clinical observations and investigations have indicated that rifampicin itself accelerates the metabolism of various other compounds, including oral anticoagulants, the contraceptive pill, oral hypoglycaemic agents and digitoxin. Rifampicin seems to be a potent inducer of drug metabolism in humans and it causes a proliferation of the smooth endoplasmatic reticulum and an increase of cytochrome P450 content in the liver. It also increases its own rate of desacetylation. However, of the test compounds hexobarbitone and tolbutamide, the metabolic clearance increased 2-to 3-fold following rafampicin treatment, whereas antipyrine clearance was unaltered. This indicates that there is a certain selectivity in the enzyme induction effect of rifampicin, although it reamins unclear which compound will and which will not be affected. Rifampicin may also possibly interfere with hepatic uptake of other compounds, but the clinical significance of this type of interaction has not been clearly demonstrated; On the other hand, oral probenecid significantly increases the serum level of rifampicin, probably due to a similar depression of hepatic uptake.

  8. Time reversal interactive objects

    NASA Astrophysics Data System (ADS)

    Ing, Ros Ki; Quieffin, Nicolas; Catheline, Stefan; Fink, Mathias

    2001-05-01

    Time reversal has shown to be a fruitful concept in nondestructive testing in underwater acoustic or in ultrasonic imaging. In this paper this technique is adapted in the audible range to transform every day objects into tactile sensitive interfaces. A quick historical background is presented in the ultrasonic field and specially in chaotic cavity. In all time reversal experiments, it is demonstrated that a wave field spatially and temporally recorded is able to back propagate to its source. In other words, the field contains all the information on the location of the source. In the interactive experiments, it is shown that touching an object like a window, a table or a world globe generates an acoustic field easily detectable with one or two acoustic sensors. Using the concept of time reversal, the source location is deduced in real time. Then, touching objects at specific locations (virtual switches) is used to activate devices. Such devices are for example lights, stereo volume, or computer software. From a technical point of view, all these interactive experiments just use some computation easily performed with a standard personnel computer.

  9. Neutron Star - Magnetosphere Interactions

    NASA Astrophysics Data System (ADS)

    Ponce, Marcelo; Anderson, Matthew; Lehner, Luis; Liebling, Steven L.; Palenzuela, Carlos

    2012-03-01

    In this work we report results of the interaction of a neutron star magnetosphere in both collapsing and moving scenarios interacting with an ambient magnetic field. In recent works [1,2], it has been shown the important role and realism associated with studies of electromagnetic environments in some particular regimes, such as: ideal-MHD, force-free, and electro-vacuum. Motivated by this and their astrophysical implications for BBH and hybrid BH-NS mergers [3,4], we study the following cases: collapse of a magnetized NS, head-on collision of a BH-NS, and orbiting merger of a BH-NS. Based in the results from our simulations, we draw some relevant conclusions to the production of jets as described within the force-free formalism. [4pt] [1] C.Palenzuela, L.Lehner and S.Liebling, Science 329, 927 (2010).[0pt] [2] C.Palenzuela, T.Garrett, et al., Phys.Rev.D 82, 044045 (2010).[0pt] [3] L.Lehner, C.Palenzuela, et al., 2011.[0pt] [4] S.Liebling, L.Lehner, et al., Phys.Rev.D 81, 124023 (2010).

  10. Cotton and Protein Interactions

    SciTech Connect

    Goheen, Steven C.; Edwards, J. V.; Rayburn, Alfred R.; Gaither, Kari A.; Castro, Nathan J.

    2006-06-30

    The adsorbent properties of important wound fluid proteins and cotton cellulose are reviewed. This review focuses on the adsorption of albumin to cotton-based wound dressings and some chemically modified derivatives targeted for chronic wounds. Adsorption of elastase in the presence of albumin was examined as a model to understand the interactive properties of these wound fluid components with cotton fibers. In the chronic non-healing wound, elastase appears to be over-expressed, and it digests tissue and growth factors, interfering with the normal healing process. Albumin is the most prevalent protein in wound fluid, and in highly to moderately exudative wounds, it may bind significantly to the fibers of wound dressings. Thus, the relative binding properties of both elastase and albumin to wound dressing fibers are of interest in the design of more effective wound dressings. The present work examines the binding of albumin to two different derivatives of cotton, and quantifies the elastase binding to the same derivatives following exposure of albumin to the fiber surface. An HPLC adsorption technique was employed coupled with a colorimetric enzyme assay to quantify the relative binding properties of albumin and elastase to cotton. The results of wound protein binding are discussed in relation to the porosity and surface chemistry interactions of cotton and wound proteins. Studies are directed to understanding the implications of protein adsorption phenomena in terms of fiber-protein models that have implications for rationally designing dressings for chronic wounds.

  11. Strong-interaction nonuniversality

    SciTech Connect

    Volkas, R. R.; Foot, R.; He, X.; Joshi, G. C.

    1989-07-01

    The universal QCD color theory is extended to an SU(3)/sub 1//direct product/SU(3)/sub 2//direct product/SU(3)/sub 3/ gauge theory, where quarks of the /ital i/th generation transform as triplets under SU(3)/sub /ital i// and singlets under the other two factors. The usual color group is then identified with the diagonal subgroup, which remains exact after symmetry breaking. The gauge bosons associated with the 16 broken generators then form two massive octets under ordinary color. The interactions between quarks and these heavy gluonlike particles are explicitly nonuniversal and thus an exploration of their physical implications allows us to shed light on the fundamental issue of strong-interaction universality. Nonuniversality and weak flavor mixing are shown to generate heavy-gluon-induced flavor-changing neutral currents. The phenomenology of these processes is studied, as they provide the major experimental constraint on the extended theory. Three symmetry-breaking scenarios are presented. The first has color breaking occurring at the weak scale, while the second and third divorce the two scales. The third model has the interesting feature of radiatively induced off-diagonal Kobayashi-Maskawa matrix elements.

  12. Herb-drug interactions.

    PubMed

    Fugh-Berman, A

    2000-01-08

    Concurrent use of herbs may mimic, magnify, or oppose the effect of drugs. Plausible cases of herb-drug interactions include: bleeding when warfarin is combined with ginkgo (Ginkgo biloba), garlic (Allium sativum), dong quai (Angelica sinensis), or danshen (Salvia miltiorrhiza); mild serotonin syndrome in patients who mix St John's wort (Hypericum perforatum) with serotonin-reuptake inhibitors; decreased bioavailability of digoxin, theophylline, cyclosporin, and phenprocoumon when these drugs are combined with St John's wort; induction of mania in depressed patients who mix antidepressants and Panax ginseng; exacerbation of extrapyramidal effects with neuroleptic drugs and betel nut (Areca catechu); increased risk of hypertension when tricyclic antidepressants are combined with yohimbine (Pausinystalia yohimbe); potentiation of oral and topical corticosteroids by liquorice (Glycyrrhiza glabra); decreased blood concentrations of prednisolone when taken with the Chinese herbal product xaio chai hu tang (sho-salko-to); and decreased concentrations of phenytoin when combined with the Ayurvedic syrup shankhapushpi. Anthranoid-containing plants (including senna [Cassia senna] and cascara [Rhamnus purshiana]) and soluble fibres (including guar gum and psyllium) can decrease the absorption of drugs. Many reports of herb-drug interactions are sketchy and lack laboratory analysis of suspect preparations. Health-care practitioners should caution patients against mixing herbs and pharmaceutical drugs.

  13. Relationality and social interaction.

    PubMed

    Bottero, Wendy

    2009-06-01

    This paper explores Bourdieu's account of a relational social space, and his relative neglect of social interaction within this framework. Bourdieu includes social capital as one of the key relational elements of his social space, but says much less about it than economic or cultural capital, and levels of social capital are rarely measured in his work. Bourdieu is reluctant to focus on the content of social networks as part of his rejection of substantialist thinking. The neglect of substantive networks creates problems for Bourdieu's framework, because many of Bourdieu's core concepts rest upon assumptions about their interactional properties (in particular, the prevalence of homophilous differential association) which are left unexamined. It is argued here that Bourdieu's neglect of the substance of social networks is related to the criticisms that Bourdieu's framework often encounters, and that this neglect bears re-examination, since it is helpful to think of the ways in which differentiated social networks contribute to the development of habitus, help form fields, and so constitute the intersubjective social relations within which sociality, and practice more generally, occur.

  14. Charged Dust Aggregate Interactions

    NASA Astrophysics Data System (ADS)

    Matthews, Lorin; Hyde, Truell

    2015-11-01

    A proper understanding of the behavior of dust particle aggregates immersed in a complex plasma first requires a knowledge of the basic properties of the system. Among the most important of these are the net electrostatic charge and higher multipole moments on the dust aggregate as well as the manner in which the aggregate interacts with the local electrostatic fields. The formation of elongated, fractal-like aggregates levitating in the sheath electric field of a weakly ionized RF generated plasma discharge has recently been observed experimentally. The resulting data has shown that as aggregates approach one another, they can both accelerate and rotate. At equilibrium, aggregates are observed to levitate with regular spacing, rotating about their long axis aligned parallel to the sheath electric field. Since gas drag tends to slow any such rotation, energy must be constantly fed into the system in order to sustain it. A numerical model designed to analyze this motion provides both the electrostatic charge and higher multipole moments of the aggregate while including the forces due to thermophoresis, neutral gas drag, and the ion wakefield. This model will be used to investigate the ambient conditions leading to the observed interactions. This research is funded by NSF Grant 1414523.

  15. Cephradine antacids interaction studies.

    PubMed

    Arayne, M Saeed; Sultana, Najma; Afzal, M

    2007-07-01

    The present work comprises of interaction studies of cephradine with antacids. Cephradine is included among the first generation cephalosporin, which is active against a wide range of Gram positive and Gram-negative bacteria including penicillinase-producing staphylococci. Since the presence of complexing ligand may affect the bioavailability of a drug in blood or tissues, therefore, in order to study the probable interaction of cephradine with antacids all the reaction conditions were simulated to natural environments. Antacids are commonly used in patients complaining of GI irritations. The behavior of cephradine in presence of seven antacids i.e., simethicone, magaldrate, magnesium carbonate, magnesium hydroxide, magnesium trisilicate, sodium bicarbonate and aluminium hydroxide was studied by using standard dissolution apparatus. Cephradine was monitored both by UV and by high performance liquid chromatography. The results revealed that antacids containing polyvalent cations retarded the in vitro availability of cephradine. Moreover, these studies indicated that cephradine was strongly adsorbed on antacids; magnesium trisilicate and simeco tablets (powdered) exhibited relatively higher adsorption capacities.

  16. Mediated Discourse and Social Interaction.

    ERIC Educational Resources Information Center

    Scollon, Ron

    1999-01-01

    Suggests that future research in language and social interaction should (1) focus on studies of media or mediated discourse as forms of social interaction as one broad group; and (2) engage in the flow of postmodernist discourse. (Author/VWL)

  17. Appel pour une allocation intelligente dans le financement du système de santé au Cameroun

    PubMed Central

    Sieleunou, Isidore

    2011-01-01

    Le Cameroun utilise un système de budgétisation historique et une approche «top-down» pour allouer ses ressources de santé publique. Cependant, le pays compte 175 districts de santé dont les fortes disparités de nature épidémiologique, économique, géographique et culturelle, devraient être prises en compte pour réduire les iniquités en matière de sante publique. Comment comprendre alors que dans ces conditions, le budget des administrations publiques alloué aux différents districts de santé au Cameroun soit quasi identique alors que les défis sont si différents? L'inefficience allocative (mauvaise attribution du budget) générée par un tel système conduit vraisemblablement à une inefficience technique (mauvaise utilisation du budget). Pour la marche vers l'atteinte des objectifs du millénaire en matière de sante, il est impératif et urgent que les décideurs du secteur de la santé allouent de manière intelligente les ressources dans le système de santé. PMID:22355420

  18. Le satellite Encelade source d'ions N+ dans la magnétosphère de Saturne

    NASA Astrophysics Data System (ADS)

    Bouhram, Mehdi; Berthelier, Jean-Jacques; Illiano, Jean-Marie; Smith, Howard T.; Sittler, Edward C.; Crary, Frank J.; Young, Dave T.

    2005-12-01

    xml:lang="fr">RésuméLe premier passage de la sonde Cassini dans l'environnement de Saturne, au dessus de l'anneau E, a mis en évidence l'existence d'un plasma composé d'un mélange d'ions issus des produits de l'eau (H+, O+, OH+, H2O+) avec une faible composante en ions N+ (3 %). A partir d'un modèle simple du transport des ions dans la magnétosphère, nous montrons que la source de ces ions N+ coïncide avec le satellite Encelade. Un tel résultat peut s'expliquer par la présence de composés volatiles tels que l'ammoniac NH3 sur ce satellite de glace, supposé encore actif géologiquement, ou par la présence d'ions N+ d'origine externe préalablement implantés sur sa surface. Pour citer cet article : M. Bouhram et al., C. R. Physique 6 (2005).

  19. Le risque de détresse morale dans la pratique contemporaine des soins de santé.

    PubMed

    Austin, Wendy

    2016-05-01

    Les professionnels de la santé sont des agents moraux dont la relation fiduciaire avec le public est animée par la responsabilité et la promesse de puiser dans leurs connaissances et leurs habiletés pour aider les personnes sous leurs soins. Lorsque leur capacité à tenir cette promesse est freinée ou compromise, ils risquent de souffrir de détresse morale. Le concept de détresse morale est défini et mis en contexte dans le milieu de la santé. Les contraintes et les facteurs qui en sont à l'origine sont présentés, de même que les moyens utilisés par les professionnels de la santé et les organisations de santé pour la soulager. Un changement transformateur s'impose pour vaincre la culture du silence et maintenir un système de santé où il est possible de vivre avec sa conscience.

  20. Un cas de leishmaniose féline disséminée dans le sud de la France

    PubMed Central

    Pocholle, E.; Reyes-Gomez, E.; Giacomo, A.; Delaunay, P.; Hasseine, L.; Marty, P.

    2012-01-01

    Cet article rapporte un cas de leishmaniose féline disséminée chez un chat (Felis catus) de 14 ans, séropositif pour le FIV et vivant dans les Alpes-Maritimes (sud de la France). Le chat présente des papules érythémateuses ulcérées sur la face et l’encolure, et une lésion proliférative ulcérée sur l’oreille gauche. C’est l’examen histopathologique des lésions cutanées qui permet le diagnostic d’une leishmaniose disséminée, associée à un carcinome épidermoïde de l’oreille. 100 mg d’allopurinol administrés une fois par jour per os pendant quatre mois ont permis la rémission totale des lésions cutanées. Des prélèvements post mortem ont révélé la persistance du parasite dans l’organisme après six mois de traitement. Cet article discute de la sensibilité du chat à la leishmaniose et de son rôle potentiel de réservoir. PMID:22314243

  1. Expanding the Interaction Equivalency Theorem

    ERIC Educational Resources Information Center

    Rodriguez, Brenda Cecilia Padilla; Armellini, Alejandro

    2015-01-01

    Although interaction is recognised as a key element for learning, its incorporation in online courses can be challenging. The interaction equivalency theorem provides guidelines: Meaningful learning can be supported as long as one of three types of interactions (learner-content, learner-teacher and learner-learner) is present at a high level. This…

  2. How Interactive Is Your Whiteboard?

    ERIC Educational Resources Information Center

    Tanner, Howard; Jones, Sonia

    2007-01-01

    In this article, the authors question the assumption that interactive whiteboards (IWBs) automatically lead to interactive teaching. The authors contend that although IWBs have features that offer great potential for the development of highly interactive teaching approaches, it may be the case that teachers must have made the transition from…

  3. L'espace du mouvement: Une analyse des conflits dans les interactions entre institutrice et eleves d'une ecole maternelle

    NASA Astrophysics Data System (ADS)

    Galvão, Izabel

    1995-01-01

    The research described in this article, winner of the Gottfried Hausmann Prize for 1994, was carried out in a kindergarten in São Paolo, Brazil, using the theory developed by Henri Wallon. The aim was to examine how primary school children are affected in their development by: (a) unnecessary restrictions placed on their physical movements during lessons; and (b) failure to organize the classroom space in a way that assists the learning process. The author concludes that these factors lead to tensions in the classroom which could be avoided through a different approach to movement and space.

  4. Bunyavirus-vector interactions.

    PubMed

    Beaty, B J; Bishop, D H

    1988-06-01

    Recent advances in the genetics and molecular biology of bunyaviruses have been applied to understanding bunyavirus-vector interactions. Such approaches have revealed which virus gene and gene products are important in establishing infections in vectors and in transmission of viruses. However, much more information is required to understand the molecular mechanisms of persistent infections of vectors which are lifelong but apparently exert no untoward effect. In fact, it seems remarkable that LAC viral antigen can be detected in almost every cell in an ovarian follicle, yet no untoward effect on fecundity and no teratology is seen. Similarly the lifelong infection of the vector would seem to provide ample opportunity for bunyavirus evolution by genetic drift and, under the appropriate circumstances, by segment reassortment. The potential for bunyavirus evolution by segment reassortment in vectors certainly exists. For example the Group C viruses in a small forest in Brazil seem to constitute a gene pool, with the 6 viruses related alternately by HI/NT and CF reactions, which assay respectively M RNA and S RNA gene products (Casals and Whitman, 1960; Shope and Causey, 1962). Direct evidence for naturally occurring reassortant bunyaviruses has also been obtained. Oligonucleotide fingerprint analyses of field isolates of LAC virus and members of the Patois serogroup of bunyaviruses have demonstrated that reassortment does occur in nature (El Said et al., 1979; Klimas et al., 1981; Ushijima et al., 1981). Determination of the genotypic frequencies of viruses selected by the biological interactions of viruses and vectors after dual infection and segment reassortment is an important issue. Should a virus result that efficiently interacts with alternate vector species, the virus could be expressed in different circumstances with serious epidemiologic consequences. Dual infection of vectors with different viruses is not unlikely, because many bunyaviruses are sympatric in

  5. Human-Robot Interaction

    NASA Technical Reports Server (NTRS)

    Sandor, Aniko; Cross, E. Vincent, II; Chang, Mai Lee

    2015-01-01

    Human-robot interaction (HRI) is a discipline investigating the factors affecting the interactions between humans and robots. It is important to evaluate how the design of interfaces affect the human's ability to perform tasks effectively and efficiently when working with a robot. By understanding the effects of interface design on human performance, workload, and situation awareness, interfaces can be developed to appropriately support the human in performing tasks with minimal errors and with appropriate interaction time and effort. Thus, the results of research on human-robot interfaces have direct implications for the design of robotic systems. For efficient and effective remote navigation of a rover, a human operator needs to be aware of the robot's environment. However, during teleoperation, operators may get information about the environment only through a robot's front-mounted camera causing a keyhole effect. The keyhole effect reduces situation awareness which may manifest in navigation issues such as higher number of collisions, missing critical aspects of the environment, or reduced speed. One way to compensate for the keyhole effect and the ambiguities operators experience when they teleoperate a robot is adding multiple cameras and including the robot chassis in the camera view. Augmented reality, such as overlays, can also enhance the way a person sees objects in the environment or in camera views by making them more visible. Scenes can be augmented with integrated telemetry, procedures, or map information. Furthermore, the addition of an exocentric (i.e., third-person) field of view from a camera placed in the robot's environment may provide operators with the additional information needed to gain spatial awareness of the robot. Two research studies investigated possible mitigation approaches to address the keyhole effect: 1) combining the inclusion of the robot chassis in the camera view with augmented reality overlays, and 2) modifying the camera

  6. IDG - INTERACTIVE DIF GENERATOR

    NASA Technical Reports Server (NTRS)

    Preheim, L. E.

    1994-01-01

    The Interactive DIF Generator (IDG) utility is a tool used to generate and manipulate Directory Interchange Format files (DIF). Its purpose as a specialized text editor is to create and update DIF files which can be sent to NASA's Master Directory, also referred to as the International Global Change Directory at Goddard. Many government and university data systems use the Master Directory to advertise the availability of research data. The IDG interface consists of a set of four windows: (1) the IDG main window; (2) a text editing window; (3) a text formatting and validation window; and (4) a file viewing window. The IDG main window starts up the other windows and contains a list of valid keywords. The keywords are loaded from a user-designated file and selected keywords can be copied into any active editing window. Once activated, the editing window designates the file to be edited. Upon switching from the editing window to the formatting and validation window, the user has options for making simple changes to one or more files such as inserting tabs, aligning fields, and indenting groups. The viewing window is a scrollable read-only window that allows fast viewing of any text file. IDG is an interactive tool and requires a mouse or a trackball to operate. IDG uses the X Window System to build and manage its interactive forms, and also uses the Motif widget set and runs under Sun UNIX. IDG is written in C-language for Sun computers running SunOS. This package requires the X Window System, Version 11 Revision 4, with OSF/Motif 1.1. IDG requires 1.8Mb of hard disk space. The standard distribution medium for IDG is a .25 inch streaming magnetic tape cartridge in UNIX tar format. It is also available on a 3.5 inch diskette in UNIX tar format. The program was developed in 1991 and is a copyrighted work with all copyright vested in NASA. SunOS is a trademark of Sun Microsystems, Inc. X Window System is a trademark of Massachusetts Institute of Technology. OSF/Motif is a

  7. A Novel Pharmacological Method to Study the Chinese Medicinal Formula Hua-Zheng-Hui-Sheng-Dan

    PubMed Central

    Cao, Rui; Zhang, Hong; Guo, Jie; Liu, Xiao-hui; Liu, Chang; Zhu, Cui-hong; Wu, Xiong-zhi

    2015-01-01

    Objectives. Hua-Zheng-Hui-Sheng-Dan (HZHSD) was used as an experimental model to explore research methods of large formulae in traditional Chinese medicine (TCM) using current molecular biology approaches. Materials and Methods. The trypan blue exclusion assay was used to determine cell viability and cell numbers. Flow cytometry was used to assess cell cycle distribution and apoptosis. The concentration of cyclin D1 was analyzed by enzyme-linked immunosorbent assay. The median effect principle was used in drug combination studies. An orthogonal experimental design was used to estimate the effects of each herb at different concentrations. The HeLa xenograft mouse model was used to compare the antitumor activity of drugs in vivo. Results. Among the 35 herbs that comprise HZHSD, Radix Rehmanniae Preparata (RRP), Caesalpinia sappan (CS), Evodia rutaecarpa (ER), Folium Artemisiae Argyi (FAA), Leonurus japonicus Houtt (LJH), Tumeric (Tu), Radix Paeoniae Alba (RPA), and Trogopterus Dung (TD) effectively inhibited the proliferation of HeLa and SKOV3 cells. Only RRR had an effect on HeLa and SKOV3 cell viability. According to the median effect principle, Angelica sinensis (Oliv.) (AS), Tabanus (Ta), and Pollen Typhae (PT), which were proven to have a significant synergistic inhibitory effect on the proliferation of HeLa cells, were added to the original eight positive herbs. The combination of RPA and AS had a synergistic effect on inducing cell cycle S phase arrest and decreasing intracellular cyclin D1 in HeLa cells. By orthogonal experimental design, LJH and Tu were considered unnecessary herbs. The small formula (SHZHSD) consisted of RPA, AS, RRR, Ta., TD, PT, ER, CS, and FAA and was able to inhibit cell proliferation and induce cell apoptosis. The antitumor effects of HZHSD and SHZHSD were also compared in vivo. Conclusions. Through molecular biology approaches both in vitro and in vivo, research into single drugs, and analysis using the median effect principle and

  8. Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats

    PubMed Central

    Zhang, Rui-Xin; Fan, Arthur Yin; Zhou, An-Nan; Moudgil, Kamal D.; Ma, Zhong-Ze; Lee, David Yue-Wei; Fong, Harry HS; Berman, Brian M.; Lao, Lixing

    2010-01-01

    Ethnopharmacological relevance The herbal formula Huo Luo Xiao Ling Dan (HLXL) and its modifications have been used in traditional Chinese medicine for about one hundred years to alleviate pain and inflammation. Aim To investigate the effects of HLXL on complete Freund’s adjuvant (CFA)-induced multiple-joint arthritis in rats. Materials and Methods Male Lewis rats, 190–210g, were immunized subcutaneously at the base of the tail with 200 µl of heat-killed M. tuberculosis in mineral oil (5 mg/ml). HLXL (2.30g/kg and 4.60g/kg) or vehicle control (n=8 per group) was administered orally (i.g.) once a day between days 16–25 post-CFA injection. The rats were observed for signs of arthritis with arthritic changes (erythema, edema, induration) being scored on a scale of 0 to 4 of increasing severity using a standard scoring system. The maximum arthritis score per rat was 16. A plethysmometer was used to measure edema volume in each paw. Adverse effects of HLXL were monitored by closely observing the animals for unusual behavioral changes. Levels of tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) in local tissue were measured by enzyme-linked immunosorbent assay on day 25 post-CFA. Results HLXL significantly decreased arthritis scores between days 23–25 in the 2.30g/kg group and 21–25 in the 4.60g/kg group (p<0.05). It reduced paw edema on days 22 and 24 in the 2.30g/kg group and on days 20, 22 and 24 in the 4.60g/kg group compared to control (p<0.05). Local tissue TNF-α and IL-1β levels on day 25 post-CFA injection were significantly (p<0.05) lower in rats treated with HLXL than in control rats. No observable adverse effects were found. Conclusion The data suggest that HLXL produces significant anti-arthritic effects that may be mediated by suppressing pro-inflammatory cytokines, and it appears to be safe. PMID:19100323

  9. Tests sérologiques dans la maladie cœliaque

    PubMed Central

    Rashid, Mohsin; Lee, Jennie

    2016-01-01

    Résumé Objectif Répondre aux questions souvent posées par les généralistes et aux difficultés auxquelles ils font face lorsqu’ils prescrivent des tests sérologiques pour la maladie cœliaque et fournir des conseils pratiques pour aider à interpréter les résultats des tests. Sources de l’information Une recherche a été effectuée dans MEDLINE pour les lignes directrices sur le diagnostic et la prise en charge de la maladie cœliaque publiées en anglais entre 2000 et 2015 par des organisations professionnelles de gastro-entérologie. Message principal Pour dépister la maladie cœliaque, le dosage de l’anticorps immunoglobuline A (IgA) anti-transglutaminase tissulaire est le test de choix. Il faut mesurer le taux sérique d’IgA totale afin d’écarter un déficit sélectif en IgA et d’éviter les faux négatifs. Les patients dont le test sérologique est positif doivent être recommandés à un gastro-entérologue pour subir des biopsies de l’intestin grêle par endoscopie afin de confirmer le diagnostic. Le typage des antigènes des leucocytes humains DQ2 et DQ8 peut aider à écarter le diagnostic. Un régime sans gluten ne doit pas être entrepris avant que le diagnostic de maladie cœliaque soit confirmé. Conclusion Les tests sérologiques sont très utiles pour confirmer les soupçons d’une maladie cœliaque. Le diagnostic précoce est essentiel pour prévenir les complications liées à la maladie cœliaque.

  10. Synchronization and hydrodynamic interactions

    NASA Astrophysics Data System (ADS)

    Powers, Thomas; Qian, Bian; Breuer, Kenneth

    2008-03-01

    Cilia and flagella commonly beat in a coordinated manner. Examples include the flagella that Volvox colonies use to move, the cilia that sweep foreign particles up out of the human airway, and the nodal cilia that set up the flow that determines the left-right axis in developing vertebrate embryos. In this talk we present an experimental study of how hydrodynamic interactions can lead to coordination in a simple idealized system: two nearby paddles driven with fixed torques in a highly viscous fluid. The paddles attain a synchronized state in which they rotate together with a phase difference of 90 degrees. We discuss how synchronization depends on system parameters and present numerical calculations using the method of regularized stokeslets.

  11. Interacting neural networks

    NASA Astrophysics Data System (ADS)

    Metzler, R.; Kinzel, W.; Kanter, I.

    2000-08-01

    Several scenarios of interacting neural networks which are trained either in an identical or in a competitive way are solved analytically. In the case of identical training each perceptron receives the output of its neighbor. The symmetry of the stationary state as well as the sensitivity to the used training algorithm are investigated. Two competitive perceptrons trained on mutually exclusive learning aims and a perceptron which is trained on the opposite of its own output are examined analytically. An ensemble of competitive perceptrons is used as decision-making algorithms in a model of a closed market (El Farol Bar problem or the Minority Game. In this game, a set of agents who have to make a binary decision is considered.); each network is trained on the history of minority decisions. This ensemble of perceptrons relaxes to a stationary state whose performance can be better than random.

  12. Interactive molecular dynamics

    NASA Astrophysics Data System (ADS)

    Schroeder, Daniel V.

    2015-03-01

    Physics students now have access to interactive molecular dynamics simulations that can model and animate the motions of hundreds of particles, such as noble gas atoms, that attract each other weakly at short distances but repel strongly when pressed together. Using these simulations, students can develop an understanding of forces and motions at the molecular scale, nonideal fluids, phases of matter, thermal equilibrium, nonequilibrium states, the Boltzmann distribution, the arrow of time, and much more. This article summarizes the basic features and capabilities of such a simulation, presents a variety of student exercises using it at the introductory and intermediate levels, and describes some enhancements that can further extend its uses. A working simulation code, in html5 and javascript for running within any modern Web browser, is provided as an online supplement.

  13. Fluid structure interaction

    NASA Astrophysics Data System (ADS)

    Komatsu, K.

    A few nonflow field problems are considered, taking into account mainly fluid-shell dynamic interaction and fluid-solid impact. Fluid-shell systems are used as models for sloshing and POGO (structure-propulsion coupling oscillation) in liquid rockets, floating lids of oil tanks, large tanks containing fluid, nuclear containment vessels, and head injury studies in biomechanics. The study of structure-water impact finds applications in the problems associated with water landings of reentry vehicles, water entry of torpedoes, and slamming of ships in heavy seas. At least three different methods can be used in handling wet structures. Attention is given to the method which treats fluid by boundary elements and structure by finite elements.

  14. Critical Density Interaction Studies

    SciTech Connect

    Young, P; Baldis, H A; Cheung, P; Rozmus, W; Kruer, W; Wilks, S; Crowley, S; Mori, W; Hansen, C

    2001-02-14

    Experiments have been performed to study the propagation of intense laser pulses to high plasma densities. The issue of self-focusing and filamentation of the laser pulse as well as developing predictive capability of absorption processes and x-ray conversion efficiencies is important for numerous programs at the Laboratory, particularly Laser Program (Fast Ignitor and direct-drive ICF) and D&NT (radiography, high energy backlighters and laser cutting). Processes such as resonance absorption, profile modification, linear mode conversion, filamentation and stimulated Brillouin scattering can occur near the critical density and can have important effects on the coupling of laser light to solid targets. A combination of experiments have been used to study the propagation of laser light to high plasma densities and the interaction physics of intense laser pulses with solid targets. Nonparaxial fluid codes to study nonstationary behavior of filamentation and stimulated Brillouin scattering at high densities have also been developed as part of this project.

  15. Parvovirus glycan interactions.

    PubMed

    Huang, Lin-Ya; Halder, Sujata; Agbandje-McKenna, Mavis

    2014-08-01

    Members of the Parvoviridae utilize glycan receptors for cellular attachment and subsequent interactions determine transduction efficiency or pathogenic outcome. This review focuses on the identity of the glycan receptors utilized, their capsid binding footprints, and a discussion of the overlap of these sites with tropism, transduction, and pathogenicity determinants. Despite high sequence diversity between the different genera, most parvoviruses bind to negatively charged glycans, such as sialic acid and heparan sulfate, abundant on cell surface membranes. The capsid structure of these viruses exhibit high structural homology enabling common regions to be utilized for glycan binding. At the same time the sequence diversity at the common footprints allows for binding of different glycans or differential binding of the same glycan.

  16. Three dimensional interactive display

    NASA Technical Reports Server (NTRS)

    Vranish, John M. (Inventor)

    2005-01-01

    A three-dimensional (3-D) interactive display and method of forming the same, includes a transparent capaciflector (TC) camera formed on a transparent shield layer on the screen surface. A first dielectric layer is formed on the shield layer. A first wire layer is formed on the first dielectric layer. A second dielectric layer is formed on the first wire layer. A second wire layer is formed on the second dielectric layer. Wires on the first wire layer and second wire layer are grouped into groups of parallel wires with a turnaround at one end of each group and a sensor pad at the opposite end. An operational amplifier is connected to each of the sensor pads and the shield pad biases the pads and receives a signal from connected sensor pads in response to intrusion of a probe. The signal is proportional to probe location with respect to the monitor screen.

  17. Interactive TV Narrativity

    NASA Astrophysics Data System (ADS)

    Ursu, Marian F.

    Looking back over the past 25 years, the impressive developments in information and communication technologies generated a booming popularity of the new forms of media consumption that allow for interactivity and mobility, such as Web information and entertainment and games. This was and still is particularly evident within the younger generation, who are the most avid adopters of both new technologies and new forms of media consumption (Schadler 2006; KPMG 2007). When asked, in 2006, which device they could not live without, 37% mentioned their PC, 26% their mobile phone, whereas only 17% mentioned their TVs (Schadler 2006); and all these were before the launch of products such as the iPhone, which offer increasing flexibility and mobility of the media experiences.

  18. Universality in string interactions

    NASA Astrophysics Data System (ADS)

    Huang, Yu-tin; Schlotterer, Oliver; Wen, Congkao

    2016-09-01

    In this note, we provide evidence for universality in the low-energy expansion of tree-level string interactions. More precisely, in the α'-expansion of tree-level scattering amplitudes, we conjecture that the leading transcendental coefficient at each order in α' is universal for all perturbative string theories. We have checked this universality up to seven points and trace its origin to the ability to restructure the disk integrals of open bosonic string into those of the superstring. The accompanying kinematic functions have the same low-energy limit and do not introduce any transcendental numbers in their α'-corrections. Universality in the closed-string sector then follows from KLT-relations.

  19. Drugging Membrane Protein Interactions

    PubMed Central

    Yin, Hang; Flynn, Aaron D.

    2016-01-01

    The majority of therapeutics target membrane proteins, accessible on the surface of cells, to alter cellular signaling. Cells use membrane proteins to transduce signals into cells, transport ions and molecules, bind the cell to a surface or substrate, and catalyze reactions. Newly devised technologies allow us to drug conventionally “undruggable” regions of membrane proteins, enabling modulation of protein–protein, protein–lipid, and protein–nucleic acid interactions. In this review, we survey the state of the art in high-throughput screening and rational design in drug discovery, and we evaluate the advances in biological understanding and technological capacity that will drive pharmacotherapy forward against unorthodox membrane protein targets. PMID:26863923

  20. Tracking protein aggregate interactions

    PubMed Central

    Bartz, Jason C; Nilsson, K Peter R

    2011-01-01

    Amyloid fibrils share a structural motif consisting of highly ordered β-sheets aligned perpendicular to the fibril axis.1, 2 At each fibril end, β-sheets provide a template for recruiting and converting monomers.3 Different amyloid fibrils often co-occur in the same individual, yet whether a protein aggregate aids or inhibits the assembly of a heterologous protein is unclear. In prion disease, diverse prion aggregate structures, known as strains, are thought to be the basis of disparate disease phenotypes in the same species expressing identical prion protein sequences.4–7 Here we explore the interactions reported to occur when two distinct prion strains occur together in the central nervous system. PMID:21597336

  1. Herbal supplements and therapeutic drug monitoring: focus on digoxin immunoassays and interactions with St. John's wort.

    PubMed

    Dasgupta, Amitava

    2008-04-01

    Herbal supplements can affect concentrations of therapeutic drugs measured in biological fluids by different mechanisms. Herbal products can either directly interfere with the methodology used in the measurement of drugs or indirectly interfere by altering the pharmacokinetics of coadministered drugs. The active components of Chan Su, Lu-Shen-Wan, Dan Shen, Asian and Siberian ginseng, oleander containing supplements, and Ashwagandha interfere with digoxin measurements by immunoassays, especially the polyclonal antibody-based immunoassays. Herbal supplements are sometimes contaminated with Western drugs causing drug toxicity. A therapeutic drug monitoring (TDM) service is very helpful for diagnosis of drug toxicity in such patients. Herbal products such as St. John's wort, a popular herbal antidepressant, increase the clearance of certain drugs either by increasing the activity of liver or intestinal cytochrome P-450 mixed-function oxidase or through modulation of the P-glycoprotein efflux pump. Significantly reduced concentrations of various therapeutic drugs such as digoxin, theophylline, cyclosporine, tacrolimus, tricyclic antidepressants, warfarin, and protease inhibitors can be observed due to interaction of these drugs with St. John's wort, causing treatment failure. On the other hand, a few drugs such as carbamazepine, mycophenolic acid, and procainamide do not show any interaction with St. John's wort. Understanding the effect of herbal products on TDM methodologies and identification of interactions between herbal products and drugs by TDM are very important clinically.

  2. Glycosaminoglycan-lipoprotein interaction.

    PubMed

    Olsson, U; Ostergren-Lundén, G; Moses, J

    2001-10-01

    Glycosaminoglycans (GAGs) bound to various proteoglycans (PGs) present in the cardiovascular system have been proposed to perform a wide range of functions. These include conferring viscoelastic properties; interacting with and modulating growth factors and enzymes; and as receptors and co-receptors in lipoprotein metabolism. Binding of apoB-100 lipoproteins, particularly low density lipoproteins (LDL), to GAGs of extracellular matrix PGs in arteries has been proposed to be an initiating event in development of atherosclerosis. This study was initiated with the aim of getting an overview of the binding patterns of different lipoprotein subclasses with individual GAG categories. We thus evaluated the interaction of lipoproteins with GAGs commonly found in the cardiovascular system using a gel mobility-shift assay developed for this purpose. The same procedure was used to measure lipoproteins binding to metabolically [(35)S]-labeled whole PGs prepared from three cell types, arterial smooth muscle cells, THP-1 macrophages and from HepG2 cells. The effect of GAG composition on PGs on lipoprotein binding was evaluated by enzymatic degradation of the carbohydrate chains. Heparan sulfate was found to bind beta very low density lipoproteins (beta-VLDL) and a chylomicron remnant model (beta-VLDL+apoE), but not LDL. Dermatan sulfate was found to bind LDL, but not beta-VLDL or the chylomicron remnant model. Chondroitin sulfate and heparin were found to bind all lipoproteins tested (LDL, beta-VLDL and beta-VLDL+apoE) although with different affinities. We can conclude that each lipoprotein subclass tested binds a specific assortment of the GAGs tested. The observations made contribute to the understanding of new and complex mechanisms by which carbohydrate and lipid metabolism may be linked.

  3. 78 FR 16650 - In the Matter of: Dan Tran Dang, 1010 W. Moore Street, Santa Ana, CA 92707; Order Denying Export...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Bureau of Industry and Security In the Matter of: Dan Tran Dang, 1010 W. Moore Street, Santa Ana, CA... address at: 1010 W. Moore Street, Santa Ana, CA 92707, and when acting for or on behalf of Dang,...

  4. Détermination du champ électromagnétique dans un résonateur linéaire supraconducteur à HTC

    NASA Astrophysics Data System (ADS)

    Trotel, A.; Sautrot, S.; Pyee, M.

    1994-11-01

    In this paper, the electromagnetic field configuration in a linear SHTC resonator is described. Two areas are considered : 1) the superconducting strip, 2) the dielectric around the strip. The calculation is based on the current density given by Bowers [1, 2] for an infinite superconducting line. The current density in the resonator is defined by these relations and the resonance conditions. Cet article décrit la configuration du champ électromagnétique dans un résonateur linéaire SHTC. Deux domaines sont considérés : 1) dans le ruban supraconducteur, 2) dans le milieu diélectrique entourant le ruban. Ce calcul s'appuie sur la densité de courant donnée par Bowers [1, 2] pour une ligne infinie supraconductrice. La densité de courant dans le résonateur est définie par ces relations et les conditions de résonance.

  5. Generation d'impulsions breves utilisant la non-linearite associee aux porteurs de charge libres dans des semi-conducteurs

    NASA Astrophysics Data System (ADS)

    Richard, Isabelle

    Dans cette these, nous utilisons la non-linearite associee aux porteurs de charge libres generes par absorption multi-photonique dans des semi-conducteurs pour produire des impulsions breves dans l'infrarouge moyen. Nous proposons d'abord la methode de generation par suppression de la transmission et auto-defocalisation, ou le faisceau incident a l'angle de Brewster genere les porteurs de charge libres, creant un profil d'indice qui defocalise le faisceau. L'impulsion resultante presente un temps de montee calque sur l'impulsion initiale, suivie d'une coupure abrupte. En polarisation TE, on obtient le decoupage par effet d'etalon ou le faisceau est incident sur un etalon oriente sur un minimum de transmission; le debut de l'impulsion est reflechi. Le changement d'indice accompagnant la creation de porteurs de charge libres syntonise la transmission de l'etalon et seule la partie centrale de l'impulsion est transmise. Enfin, le decoupage peut aussi s'effectuer en configuration pompe-sonde; un faisceau continu (sonde) est incident sur un etalon simultanement soumis a l'illumination d'une d'impulsion breve (pompe). Cette derniere genere des porteurs de charge libres, conduisant a un glissement de la frequence instantanee de la sonde. Le faisceau est envoye dans un filtre spectral qui ne transmet que la portion ayant subi un important glissement de frequence.

  6. The Effect of Danquah Communication System (DanCS) Boards on Maladaptive Behaviours among Individuals with Severe Intellectual Impairment and Non-verbal Communication Skills.

    ERIC Educational Resources Information Center

    Danquah, S. A.; And Others

    1996-01-01

    Danquah Communication System (DanCS) symbol boards were developed to provide an inexpensive augmented communication device with a computerized voice interface to help nonverbal individuals with severe mental retardation or other severe disabilities to more easily communicate their needs and reduce aggressive behaviors. Evaluation with 30 subjects…

  7. Go for the Goal: The Dan O'Brien Goal-Setting Program. A Goal-Setting Program for Grades 3 to 6.

    ERIC Educational Resources Information Center

    Stolp, Stephen; Stolp, Patricia

    This booklet is a product of the Dan O'Brien Education Program, which was created in 1993 by the Educational Resources Information Center Clearinghouse on Educational Management. The program was designed to help young people gain the most from their education. It outlines five lessons for setting and achieving goals: (1) window of opportunity; (2)…

  8. Introduction d'une représentation dynamique de matériau dans l'équation de diffusion du champ magnétique

    NASA Astrophysics Data System (ADS)

    Raulet, M. A.; Masson, J. P.; Gaude, D.

    1998-01-01

    The knowledge of the dynamical behavior of magnetic materials is of first importance in the iron losses prediction. For the simple shaped Epstein frame, the field diffusion equation resolution in the laminations cross section, limited to eddy currents, leads to inaccurate results. This paper presents a simple method to take into account dynamical distributed phenomena in the field diffusion equation. The study will be limited to dynamical first magnetization excitations. La connaissance du comportement dynamique des matériaux magnétiques est importante pour l'évaluation des pertes fer dans les machines électriques. Pour les sollicitations simples d'une tôle dans un cadre Epstein ou un tore fin, la résolution de l'équation de la diffusion du champ magnétique dans le plan de la section de la tôle limitée aux seuls courants de Foucault, ne fournit qu'une description insuffisamment précise des phénomènes. Cet article présente une méthode simple de prise en compte des phénomènes dynamiques locaux dans l'équation de diffusion. L'étude sera limitée à des sollicitations de première aimantation dynamique. Une validation expérimentale de ce modèle en fonction de la fréquence est aussi présentée.

  9. Artificial Neural Network Approaches in Guidance and Control (Les Reseaux Neuroniques Artificiels, Voie a Explorer dans le Domaine du Guidage et du Pilotage)

    DTIC Science & Technology

    1991-09-01

    groupe de conf6renciers des pays membres de I’OTAN ayant une experience exceptionnelle dans ce nouveau domaine technologique . Les aspects fondamentaux...DESMOUCEAUX J., BUREL G., (Thomson- proceedings CSF) Application des r~seaux de neurones a Comparison of various neural and classical la veille

  10. Water equivalent hydrogen estimates from the first 200 sols of Curiosity's traverse (Bradbury Landing to Yellowknife Bay): Results from the Dynamic Albedo of Neutrons (DAN) passive mode experiment

    NASA Astrophysics Data System (ADS)

    Tate, C. G.; Moersch, J.; Jun, I.; Ming, D. W.; Mitrofanov, I.; Litvak, M.; Behar, A.; Boynton, W. V.; Deflores, L.; Drake, D.; Ehresmann, B.; Fedosov, F.; Golovin, D.; Hardgrove, C.; Harshman, K.; Hassler, D. M.; Kozyrev, A. S.; Kuzmin, R.; Lisov, D.; Malakhov, A.; Milliken, R.; Mischna, M.; Mokrousov, M.; Nikiforov, S.; Sanin, A. B.; Starr, R.; Varenikov, A.; Vostrukhin, A.; Zeitlin, C.

    2015-12-01

    The Dynamic Albedo of Neutrons (DAN) experiment on the Mars Science Laboratory (MSL) rover Curiosity is designed to detect neutrons to determine hydrogen abundance within the subsurface of Mars (Mitrofanov, I.G. et al. [2012]. Space Sci. Rev. 170, 559-582. http://dx.doi.org/10.1007/s11214-012-9924-y; Litvak, M.L. et al. [2008]. Astrobiology 8, 605-613. http://dx.doi.org/10.1089/ast.2007.0157). While DAN has a pulsed neutron generator for active measurements, in passive mode it only measures the leakage spectrum of neutrons produced by the Multi-Mission Radioisotope Thermoelectric Generator (MMRTG) and Galactic Cosmic Rays (GCR). DAN passive measurements provide better spatial coverage than the active measurements because they can be acquired while the rover is moving. Here we compare DAN passive-mode data to models of the instrument's response to compositional differences in a homogeneous regolith in order to estimate the water equivalent hydrogen (WEH) content along the first 200 sols of Curiosity's traverse in Gale Crater, Mars. WEH content is shown to vary greatly along the traverse. These estimates range from 0.5 ± 0.1 wt.% to 3.9 ± 0.2 wt.% for fixed locations (usually overnight stops) investigated by the rover and 0.6 ± 0.2 wt.% to 7.6 ± 1.3 wt.% for areas that the rover has traversed while continuously acquiring DAN passive data between fixed locations. Estimates of WEH abundances at fixed locations based on passive mode data are in broad agreement with those estimated at the same locations using active mode data. Localized (meter-scale) anomalies in estimated WEH values from traverse measurements have no particular surface expression observable in co-located images. However at a much larger scale, the hummocky plains and bedded fractured units are shown to be distinct compositional units based on the hydrogen content derived from DAN passive measurements. DAN passive WEH estimates are also shown to be consistent with geologic models inferred from other

  11. La singularité du patient tuberculeux dans le système de santé: l'expérience du Burkina Faso

    PubMed Central

    Zerbo, Roger

    2013-01-01

    La démarche pluridisciplinaire s'impose de plus en plus dans le secteur de la santé dans le contexte africain, où les parcours thérapeutiques sont pluriels et les rapports des usagers des centres de santé sont complexes et peu satisfaisants. La compréhension des représentations de la maladie est nécessaire pour offrir des soins appropriés certes, mais l'expérience individuelle des malades représente également une source de savoir. Les données ont été collectées à travers des entretiens semi-directifs, le recueil des récits de vie et des observations participantes. Cet article rend compte d'une expérience d'implication de socio-anthropologue dans la mise en œuvre d'un programme de santé publique au Burkina Faso en vue d'une amélioration de la prise en charge des malades tuberculeux. L'analyse des données à été conduite dans une visée réflexive. Les perspectives socio-anthropologiques ont révélé que l'expérience des anciens malades tuberculeux peut être mise à profit afin d'apporter des changements dans les relations thérapeutiques et l'intégration sociale des autres malades. Cette idée à été mise en application pour tenir lieu d'une traduction des analyses anthropologiques en actes pour un changement. L'article évoque la manière dont l'approche socio-anthropologique au sein d'un programme de santé, peut mettre en évidence le potentiel des malades à être des acteurs importants dans le fonctionnement des services de soins et leur propre bien-être. Dans cette situation, la démarche théorique implique la réflexivité de l'anthropologue, mais également un regard critique sur les modes d'intervention en santé publique. PMID:24009798

  12. Polymer-Nucleic Acid Interactions.

    PubMed

    Shen, Zhuang-Lin; Xia, Yi-Qi; Yang, Qiu-Song; Tian, Wen-de; Chen, Kang; Ma, Yu-Qiang

    2017-04-01

    Gene therapy is an important therapeutic strategy in the treatment of a wide range of genetic disorders. Polymers forming stable complexes with nucleic acids (NAs) are non-viral gene carriers. The self-assembly of polymers and nucleic acids is typically a complex process that involves many types of interaction at different scales. Electrostatic interaction, hydrophobic interaction, and hydrogen bonds are three important and prevalent interactions in the polymer/nucleic acid system. Electrostatic interactions and hydrogen bonds are the main driving forces for the condensation of nucleic acids, while hydrophobic interactions play a significant role in the cellular uptake and endosomal escape of polymer-nucleic acid complexes. To design high-efficiency polymer candidates for the DNA and siRNA delivery, it is necessary to have a detailed understanding of the interactions between them in solution. In this chapter, we survey the roles of the three important interactions between polymers and nucleic acids during the formation of polyplexes and summarize recent understandings of the linear polyelectrolyte-NA interactions and dendrimer-NA interactions. We also review recent progress optimizing the gene delivery system by tuning these interactions.

  13. Developing a general interaction potential for hydrophobic and hydrophilic interactions.

    PubMed

    Donaldson, Stephen H; Røyne, Anja; Kristiansen, Kai; Rapp, Michael V; Das, Saurabh; Gebbie, Matthew A; Lee, Dong Woog; Stock, Philipp; Valtiner, Markus; Israelachvili, Jacob

    2015-02-24

    We review direct force measurements on a broad class of hydrophobic and hydrophilic surfaces. These measurements have enabled the development of a general interaction potential per unit area, W(D) = -2γ(i)Hy exp(-D/D(H)) in terms of a nondimensional Hydra parameter, Hy, that applies to both hydrophobic and hydrophilic interactions between extended surfaces. This potential allows one to quantitatively account for additional attractions and repulsions not included in the well-known combination of electrostatic double layer and van der Waals theories, the so-called Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. The interaction energy is exponentially decaying with decay length D(H) ≈ 0.3-2 nm for both hydrophobic and hydrophilic interactions, with the exact value of D(H) depending on the precise system and conditions. The pre-exponential factor depends on the interfacial tension, γ(i), of the interacting surfaces and Hy. For Hy > 0, the interaction potential describes interactions between partially hydrophobic surfaces, with the maximum hydrophobic interaction (i.e., two fully hydrophobic surfaces) corresponding to Hy = 1. Hydrophobic interactions between hydrophobic monolayer surfaces measured with the surface forces apparatus (SFA) are shown to be well described by the proposed interaction potential. The potential becomes repulsive for Hy < 0, corresponding to partially hydrophilic (hydrated) interfaces. Hydrated surfaces such as mica, silica, and lipid bilayers are discussed and reviewed in the context of the values of Hy appropriate for each system.

  14. Discovering interacting domains and motifs in protein-protein interactions.

    PubMed

    Hugo, Willy; Sung, Wing-Kin; Ng, See-Kiong

    2013-01-01

    Many important biological processes, such as the signaling pathways, require protein-protein interactions (PPIs) that are designed for fast response to stimuli. These interactions are usually transient, easily formed, and disrupted, yet specific. Many of these transient interactions involve the binding of a protein domain to a short stretch (3-10) of amino acid residues, which can be characterized by a sequence pattern, i.e., a short linear motif (SLiM). We call these interacting domains and motifs domain-SLiM interactions. Existing methods have focused on discovering SLiMs in the interacting proteins' sequence data. With the recent increase in protein structures, we have a new opportunity to detect SLiMs directly from the proteins' 3D structures instead of their linear sequences. In this chapter, we describe a computational method called SLiMDIet to directly detect SLiMs on domain interfaces extracted from 3D structures of PPIs. SLiMDIet comprises two steps: (1) interaction interfaces belonging to the same domain are extracted and grouped together using structural clustering and (2) the extracted interaction interfaces in each cluster are structurally aligned to extract the corresponding SLiM. Using SLiMDIet, de novo SLiMs interacting with protein domains can be computationally detected from structurally clustered domain-SLiM interactions for PFAM domains which have available 3D structures in the PDB database.

  15. Interactive Projector as an Interactive Teaching Tool in the Classroom: Evaluating Teaching Efficiency and Interactivity

    ERIC Educational Resources Information Center

    Liu, Li-Ying; Cheng, Meng-Tzu

    2015-01-01

    This study reports on a measurement that is used to investigate interactivity in the classrooms and examines the impact of integrating the interactive projector into middle school science classes on classroom interactivity and students' biology learning. A total of 126 7th grade Taiwanese students were involved in the study and quasi-experimental…

  16. Étude ethnobotanique des plantes utilisées dans le traitement du diabète dans la médecine traditionnelle de la région Maritime du Togo

    PubMed Central

    Holaly, Gbekley Efui; Simplice, Karou Damintoti; Charlemagne, Gnoula; Kodjovi, Agbodeka; Kokou, Anani; Tchadjobo, Tchacondo; Amegnona, Agbonon; Komlan, Batawila; Jacques, Simpore

    2015-01-01

    Introduction Les plantes constituent une grande source de principes actifs qui peuvent être utilisés pour traiter de nombreuses maladies, dont le diabète. L'objectif de cette étude était de recenser les plantes utilisées en médecine traditionnelle pour traiter le diabète dans la région Maritime du Togo. Méthodes De janvier 2013 à juin 2014, une enquête ethnobotanique a été réalisée auprès de 164 guérisseurs traditionnels dans la région Maritime par des interviews directes à l'aide d'un questionnaire semi structuré. Résultats Les données recueillies ont permis d'identifier 112 espèces végétales appartenant à 51 familles. Les familles les plus représentées ont été les Caesalpiniaceae / Fabaceae avec 9 espèces, suivie des Euphorbiaceae et des Compositae avec 8 espèces chacune. Les espèces les plus citées ont été Allium sativum, Alium cepa, Guilandina bonduc, Moringa oleifera et de Picralima nitida qui ont eu une valeur usuelle de 0,05. En termes de recettes, 132 recettes sont préparées à partir des 112 espèces de plantes. Les recettes à plantes uniques ont été au nombre de 78, tandis que 54 recettes sont obtenues par des associations de plantes. Les parties de plantes les plus utilisées ont été les feuilles suivies par les racines. La principale méthode de préparation reste la décoction. Conclusion La région maritime du Togo dispose d'une biodiversité floristique importante en matière de plantes antidiabétiques. Ces résultats constituent une bonne base de données pour le criblage biologique dans la recherche de molécules antidiabétiques à base des plantes. PMID:26309469

  17. Apport de la tomodensitométrie dans le diagnostic de la tuberculose vertébrale à propos de 496 cas à Abidjan

    PubMed Central

    Gbané-Koné, Mariam; Ouattara, Baly; Diomandé, Mohamed; Sessou, Viva; Kaboré, Fulgence; Djoko, Kouadio Flore; Traoré, Moriba; Eti, Edmond; Kouakou, N'zué Marcel

    2015-01-01

    Introduction Le mal de Pott est la forme la plus fréquente des tuberculoses ostéo articulaires, le diagnostic de certitude reste difficile. L'imagerie tient une place indéniable dans le diagnostic. L'objectif de cette étude était de déterminer la prévalence de la tuberculose vertébrale et l'apport de la TDM dans le diagnostic. Méthodes Nous avons mené une étude rétrospective sur dossiers de tuberculose vertébrale dans le service de Rhumatologie du CHU de Cocody de Janvier 2006 à Décembre 2013. N'ont pas été inclus dans l’étude, tous les dossiers ne comportant pas d'imagerie. Resultats La prévalence hospitalière de la tuberculose vertébrale était de 10,95%, elle représentait 90,2% de la tuberculose ostéoarticulaire. Elle concernait les 2 sexes, l’âge moyen était de 43,27 ans (4-88ans). L'atteinte dorsolombaire était la localisation la plus fréquente (95,13%). L'atteinte du rachis cervical était rare. La spondylodiscite était fréquente (92,14%). La spondylite (6%) et l'atteinte de l'arc postérieur (0,86%) étaient rares. La spondylodiscite était unique le plus souvent (70,05%), les formes multiétagées ont été notées dans 28,65% des cas, les atteintes mutifocales ont été notées dans14, 63% des cas. Les localisations inhabituelles étaient: atteinte sous occipitale (n=3), atteinte concomitante des 3 segments rachidiens (n=3), atteinte du sacrum (n=1), abcès isolés du psoas (n=4). La prévalence des abcès était de 85,91%, celle des épidurites était de 80,17%. La ponction scannoguidée des abcès a été réalisée dans 20 cas, la recherche de BAAR était positive dans 15 cas. Il existait une tuberculose viscérale évolutive dans 20% des cas. Conclusion La TDM est indéniable dans le diagnostic positif et lésionnel de la tuberculose vertébrale. Le retard au diagnostic explique l’étendue des lésions. PMID:26113932

  18. The mechanical interactions between an American football cleat and playing surfaces in-situ at loads and rates generated by elite athletes: a comparison of playing surfaces.

    PubMed

    Kent, Richard; Forman, Jason L; Crandall, Jeff; Lessley, David

    2015-03-01

    This study quantified the mechanical interactions between an American football cleat and eight surfaces used by professional American football teams. Loading conditions were applied with a custom-built testing apparatus designed to represent play-relevant maneuvers of elite athletes. Two natural grass and six infill artificial surfaces were tested with the cleated portion of a shoe intended for use on either surface type. In translation tests with a 2. 8-kN vertical load, the grass surfaces limited the horizontal force on the cleats by tearing. This tearing was not observed with the artificial surfaces, which allowed less motion and generated greater horizontal force (3.2 kN vs. 4.5 kN, p < 0.05). Similarly, rotation tests generated less angular displacement and greater torque on the artificial surfaces (145 N m vs. 197 N m, p < 0.05). Translation/drop tests, in which the foot-form was launched into the surfaces with both horizontal and vertical velocity components generated less peak horizontal force on the natural surfaces than on the artificial surfaces (2.4 kN vs. 3.0 kN, p < 0.05). These results suggest a force-limiting mechanism inherent to natural grass surfaces. Future work should consider implications of these findings for performance and injury risk and should evaluate the findings' sensitivity to cleat pattern and playing conditions.

  19. Arc electrode interaction study

    NASA Technical Reports Server (NTRS)

    Zhou, X.; Berns, D.; Heberlein, J.

    1994-01-01

    The project consisted of two parts: (1) the cathode interaction studies which were a continuation of previous work and had the objective of increasing our understanding of the microscopic phenomena controlling cathode erosion in arc jet thrusters, and (2) the studies of the anode attachment in arc jet thrusters. The cathode interaction studies consisted of (1) a continuation of some modeling work in which the previously derived model for the cathode heating was applied to some specific gases and electrode materials, and (2) experimental work in which various diagnostics was applied to the cathode. The specific diagnostics used were observation of the cathode tip during arcing using a Laser Strobe Video system in conjunction with a tele-microscope, a monochromator with an optical multichannel analyzer for the determination of the cathode temperature distribution, and various ex situ materials analysis methods. The emphasis of our effort was shifted to the cathode materials analysis because a parallel project was in place during the second half of 1993 with a visiting scientist pursuing arc electrode materials studies. As a consequence, the diagnostic investigations of the arc in front of the cathode had to be postponed to the first half of 1994, and we are presently preparing these measurements. The results of last year's study showed some unexpected effects influencing the cathode erosion behavior, such as increased erosion away from the cathode tip, and our understanding of these effects should improve our ability to control cathode erosion. The arc jet anode attachment studies concentrated on diagnostics of the instabilities in subsonic anode attachment arc jet thrusters, and were supplemental measurements to work which was performed by one of the authors who spent the summer as an intern at NASA Lewis Research Center. A summary of the results obtained during the internship are included because they formed an integral part of the study. Two tasks for 1994, the

  20. Séroprévalence de l’AgHBs chez la femme enceinte dans le centre du Maroc

    PubMed Central

    Sbiti, Mohammed; Khalki, Hanane; Benbella, Imane; louzi, Lhoussaine

    2016-01-01

    La transmission materno-fœtale du virus de l'hépatite B (VHB) est un problème qui préoccupe toujours les autorités sanitaires à travers le monde et suscite la mise en place de mesures préventives renforcées. Le statut réplicatif du virus chez la mère séropositive, évalué par la positivité de l'AgHbe et le taux de la charge virale, conditionne le risque de contamination qui est plus important en période péri-natale. Les mères porteuses chroniques du VHB constituent un véritable réservoir de la transmission verticale de cette infection. Nous avons étudié, à travers cette enquête sur 1120 femmes enceintes Marocaines, la séroprévalence de l'AgHBs qui était de 2,35%, dans le but d'alimenter les données nationales sur ce sujet. Parmi ces femmes séropositives pour l'AgHBs, 79,1% avaient un AgHBe négatif et ont bénéficié d'une recherche moléculaire qui s'est révélée positive dans 89,4% des cas. La vaccination de la femme en âge de procréer est l'un des piliers majeurs de la prévention de la transmission verticale du VHB, seulement 2,4% de nos patientes étaient vaccinées. Ceci relève l'intérêt du dépistage au cours de la grossesse, qui doit se focaliser sur la sensibilisation à la vaccination de femmes séronégatives, et le suivi par biologie moléculaire des mères séropositives dans le but d'instaurer un traitement prophylactique adéquat. PMID:27795784

  1. Identification des risques professionnels dans l'industrie textile en République Démocratique du Congo

    PubMed Central

    Kitronza, Panda Lukongo

    2014-01-01

    Introduction Le but de cette étude est de mettre en évidence les facteurs de risques professionnels liés aux conditions de travail. Méthodes Cette étude qualitative basée sur les entretiens de groupe a été réalisée par une équipe pluridisciplinaire dans l'industrie textile de la région du Est de la RDC; comprenant un médecin de travail, un médecin de santé publique, un toxicologue, deux infirmiers du centre hospitalier de l'usine, un représentant du comité d'hygiène et un technicien de prévention. La démarche méthodologique a consisté en des entretiens en groupe, des observations et visites guidées de lieux de travail de l'entreprise. Résultats Dans la culture du coton, les effets d'une forte exposition aux pesticides peuvent entraîner des intoxications aiguës, chroniques et voire le décès. Les autres risques sont les accidents de travail, les maladies professionnelles, les troubles psychologiques. Dans l'industrie, les travailleurs sont exposés aux risques liés à l'empoussiérage des fibres de coton, aux facteurs des risques traumatiques, physiques (bruits, vibration) et chimiques (acides forts, bases fortes, solvants et colorants minéraux), ainsi qu'aux risques psychosociaux. La pollution de l'environnement et l’écotoxicité inhérente à ces activités restent l'effet de l'usage des grandes quantités d'intrants agricoles, engrais et produits phytosanitaires. Conclusion Cette étude a permis de mettre en évidence les différents facteurs de risques auxquelles sont soumis les travailleurs textiles; ainsi que les risques environnementaux liés à cette activité. Cela est de nature à permettre la mise sur pied d'une stratégie efficace de prévention et de protection des travailleurs. PMID:25977736

  2. Apport de l'endoscopie digestive dans l'hypertension portale de l'enfant: à propos de 68 cas

    PubMed Central

    Idrissi, Mounia Lakhdar; Babakhoya, Abdeladim; Hida, Moustapha

    2012-01-01

    Introduction L'hypertension portale n'est pas exceptionnelle chez l'enfant. L'hémorragie digestive en est une complication redoutable pouvant mettre en jeu le pronostic vital. Cette hémorragie, pouvant être isolée, confie à l'examen endoscopique un intérêt diagnostique majeur. L'endoscopie digestive haute a également un intérêt pronostique et thérapeutique incontournable. L'objectif de ce travail était d'analyser les aspects endoscopiques de l'hypertension portale, faire une corrélation entre ces aspects et le risque hémorragique éventuel et mettre en évidence le rôle de l'endoscopie dans le traitement et la surveillance. Méthodes Notre étude est une analyse rétrospective de 135 endoscopies digestives hautes effectuées chez 68 enfants atteints d'hypertension portale sur une période de 8 ans. Résultats L'endoscopie a permis de mettre en évidence les varices œsogastriques dans 55 cas (80.9%). Elle était le premier moyen diagnostique de l'hypertension portale chez 5 patients ayant présenté une hémorragie digestive isolée. Elle a permet aussi d'apprécier le risque hémorragique qui est étroitement lié au stade des varices œsophagiennes et à la présence des varices tubérositaires. Neuf enfants ont bénéficié de la ligature élastique des varices œsophagiennes avec un taux de succès de 89%. Conclusion L'oesogastroscopie recherchant et traitant les varices œsogastriques est indispensable dans les hypertensions portales de l'enfant. Inversement, nous soulignons son intérêt majeur en matière diagnostique de l'hémorragie digestive isolée de l'enfant ou la découverte de varices pose à posteriori le diagnostic de l'hypertension portale. PMID:22937191

  3. Electron Interactions in Graphene

    NASA Astrophysics Data System (ADS)

    Kim, Philip

    2011-03-01

    Electrons confined in two dimensions (2D) can exhibit strongly correlated states. Recent experimental discovery of integer and fractional quantum Hall effect in graphene amplified interest in correlated 2D electronic systems, owning to presence of the unusual topological phase associated with zero effective mass of charge carriers. In this talk, we will discuss the role of the many-body effects due to the electron-electron interaction in graphene manifested in electron transport phenomena. In particular, we will discuss the nature unusual spontaneous symmetry breaking Landau levels graphene under the extreme quantum condition, the appearance of unique low density insulating states and fractional quantum Hall states. Employing extremely high quality samples obtained by suspending graphene and graphene on atomically flat defect free insulating substrate such as hexa-bron nitride, we now investigate various broken symmetry states under high magnetic field. The nature of these broken symmetry state can be explained generally considering underlying SU(4) symmetry in the single particle level of the Landau levels.

  4. Atmospheric Ball Plasma Interactions

    NASA Astrophysics Data System (ADS)

    Wurden, C. J. V.; Wurden, G. A.

    2008-11-01

    Free-floating atmospheric pressure copper hydroxyl ball plasmas have been studied in air and helium atmospheres, using still and high speed photography (up to 20,000 fps), collimated photodiodes, and spectroscopy. A fine boundary layer between the greenish Cu-OH cloud, and the air, is orange in color. However, when the discharge is initiated into a helium atmosphere, the boundary layer is no longer visible, suggesting that the visible boundary was caused by interactions with oxygen. We have studied scaling of the 10-cm diameter ball plasmas with both the size of the water bucket, and the applied discharge voltage, over the range of 500-5000 volts. When looking at the initial spider-leg breakdown above the water surface, the ratio of H-alpha to H-beta lines suggests a temperature of ˜0.3 eV. This is also consistent with the presence of molecular lines of OH, and perhaps CuOH2 in the rising cloud. The cloud is affected by, but can penetrate through an aluminum window screen mesh.

  5. "Interactive Classification Technology"

    NASA Technical Reports Server (NTRS)

    deBessonet, Cary

    1999-01-01

    The investigators are upgrading a knowledge representation language called SL (Symbolic Language) and an automated reasoning system called SMS (Symbolic Manipulation System) to enable the technologies to be used in automated reasoning and interactive classification systems. The overall goals of the project are: a) the enhancement of the representation language SL to accommodate multiple perspectives and a wider range of meaning; b) the development of a sufficient set of operators to enable the interpreter of SL to handle representations of basic cognitive acts; and c) the development of a default inference scheme to operate over SL notation as it is encoded. As to particular goals the first-year work plan focused on inferencing and.representation issues, including: 1) the development of higher level cognitive/ classification functions and conceptual models for use in inferencing and decision making; 2) the specification of a more detailed scheme of defaults and the enrichment of SL notation to accommodate the scheme; and 3) the adoption of additional perspectives for inferencing.

  6. SEEPAGE/BACKFILL INTERACTIONS

    SciTech Connect

    P. Mariner

    2000-04-14

    As directed by written development plan (CRWMS M&O 1999a), a sub-model of seepage/backfill interactions is developed and presented in this document to support the Engineered Barrier System (EBS) Physical and Chemical Environment Model. The purpose of this analysis is to assist Performance Assessment Operations (PAO) and the Engineered Barrier Performance Department in modeling the geochemical environment within a repository drift. In this analysis, a conceptual model is developed to provide PAO a more detailed and complete in-drift geochemical model abstraction and to answer the key technical issues (KTI) raised in the NRC Issue Resolution Status Report (IRSR) for the Evolution of the Near Field Environment (NFE) Revision 2 (NRC 1999). The development plan calls for a sub-model that evaluates the effect on water chemistry of chemical reactions between water that enters the drift and backfill materials in the drift. The development plan specifically requests an evaluation of the following important chemical reaction processes: dissolution-precipitation, aqueous complexation, and oxidation-reduction. The development plan also requests the evaluation of the effects of varying seepage and drainage fluxes, varying temperature, and varying evaporation and condensation fluxes. Many of these effects are evaluated in a separate Analysis/Model Report (AMR), ''Precipitates Salts Analysis AMR'' (CRWMS M&O 2000), so the results of that AMR are referenced throughout this AMR.

  7. Hydrogen interactions with metals

    NASA Technical Reports Server (NTRS)

    Mclellan, R. B.; Harkins, C. G.

    1975-01-01

    Review of the literature on the nature and extent of hydrogen interactions with metals and the role of hydrogen in metal failure. The classification of hydrogen-containing systems is discussed, including such categories as covalent hydrides, volatile hydrides, polymeric hydrides, and transition metal hydride complexes. The use of electronegativity as a correlating parameter in determining hydride type is evaluated. A detailed study is made of the thermodynamics of metal-hydrogen systems, touching upon such aspects as hydrogen solubility, the positions occupied by hydrogen atoms within the solvent metal lattice, the derivation of thermodynamic functions of solid solutions from solubility data, and the construction of statistical models for hydrogen-metal solutions. A number of theories of hydrogen-metal bonding are reviewed, including the rigid-band model, the screened-proton model, and an approach employing the augmented plane wave method to solve the one-electron energy band problem. Finally, the mechanism of hydrogen embrittlement is investigated on the basis of literature data concerning stress effects and the kinetics of hydrogen transport to critical sites.

  8. Influenza-Sediment Interactions

    NASA Astrophysics Data System (ADS)

    Trusiak, A.; Block, K. A.; Katz, A.; Gottlieb, P.; Alimova, A.; Galarza, J.; Wei, H.; Steiner, J. C.

    2013-12-01

    A typical water fowl can secrete 1012 influenza virions per day. Therefore it is not unexpected that influenza virions interact with sediments in the water column. The influence of sediments on avian influenza virions is not known. With the threat of avian influenza emerging into the human population, it is crucial to understand virus survivability and residence time in a body of water. Influenza and clay sediments are colloidal particles and thus aggregate as explained by DLVO (Derjaguin & Landau, Verwey & Overbeek) theory. Of great importance is an understanding of the types of particulate or macromolecular components that bind the virus particles, and whether the virus remains biologically active. We present results of hetero-aggregation and transmission electron microscopy experiments performed with influenza A/PR8/38. Influenza particles are suspended with sediment and minimal nutrients for several days, after which the components are evaluated to determine influenza concentration and survivability. Transmission electron microscopy results are reported on the influenza-sediment aggregates to elucidate structure and morphology of the components.

  9. The many faces of interaction.

    PubMed

    Reynolds, P A; Mason, R; Harper, J

    2008-05-24

    During the process of learning teachers and/or students interact with each other on a personal level. However, in e-learning the process is achieved through the intermediary of an information and communication technology (ICT) system or service. Descriptions of these ICT-human interface devices are given in this paper. Successful interaction depends not just on personal relationships, but also on understanding and the ability to use computers and communications equipment effectively. Interactivity, when using ICT, may as a result be different from that in a traditional classroom. The computer is the main man-machine interface and modulates people's ability to interact. Newer, mobile technology will extend the ability to interact in terms of time and place, as is illustrated by the use of portable digital assistants for dental teaching in clinics. The paper concludes that it is very important that both teachers and students should understand how to interact optimally with current and future ICT systems and devices.

  10. Interaction Models for Functional Regression

    PubMed Central

    USSET, JOSEPH; STAICU, ANA-MARIA; MAITY, ARNAB

    2015-01-01

    A functional regression model with a scalar response and multiple functional predictors is proposed that accommodates two-way interactions in addition to their main effects. The proposed estimation procedure models the main effects using penalized regression splines, and the interaction effect by a tensor product basis. Extensions to generalized linear models and data observed on sparse grids or with measurement error are presented. A hypothesis testing procedure for the functional interaction effect is described. The proposed method can be easily implemented through existing software. Numerical studies show that fitting an additive model in the presence of interaction leads to both poor estimation performance and lost prediction power, while fitting an interaction model where there is in fact no interaction leads to negligible losses. The methodology is illustrated on the AneuRisk65 study data. PMID:26744549

  11. Interactive Raytracing: The nirt Command

    DTIC Science & Technology

    2009-04-01

    Interactive Raytracing : The nirt Command by Clifford Yapp ARL-CR-624 April 2009 prepared by Quantum Research...Laboratory Aberdeen Proving Ground, MD 21005-5068 ARL-CR-624 April 2009 Interactive Raytracing : The nirt Command Clifford Yapp Quantum...DATES COVERED (From - To) June 2008–October 2008 4. TITLE AND SUBTITLE Interactive Raytracing : The nirt Command 5a. CONTRACT NUMBER W911QX-06-F

  12. Interactions between Chemokines

    PubMed Central

    Cook, Anna; Hippensteel, Randi; Shimizu, Saori; Nicolai, Jaclyn; Fatatis, Alessandro; Meucci, Olimpia

    2010-01-01

    The soluble form of the chemokine fractalkine/CX3CL1 regulates microglia activation in the central nervous system (CNS), ultimately affecting neuronal survival. This study aims to determine whether CXCL12, another chemokine constitutively expressed in the CNS (known as stromal cell-derived factor 1; SDF-1), regulates cleavage of fractalkine from neurons. To this end, ELISA was used to measure protein levels of soluble fractalkine in the medium of rat neuronal cultures exposed to SDF-1. Gene arrays, quantitative RT-PCR, and Western blot were used to measure overall fractalkine expression in neurons. The data show that the rate of fractalkine shedding in healthy cultures positively correlates with in vitro differentiation and survival. In analogy to non-neuronal cells, metalloproteinases (ADAM10/17) are involved in cleavage of neuronal fractalkine as indicated by studies with pharmacologic inhibitors. Moreover, treatment of the neuronal cultures with SDF-1 stimulates expression of the inducible metalloproteinase ADAM17 and increases soluble fractalkine content in culture medium. The effect of SDF-1 is blocked by an inhibitor of both ADAM10 and -17, but only partially affected by a more specific inhibitor of ADAM10. In addition, SDF-1 also up-regulates expression of the fractalkine gene. Conversely, exposure of neurons to an excitotoxic stimulus (i.e. NMDA) inhibits α-secretase activity and markedly diminishes soluble fractalkine levels, leading to cell death. These results, along with previous findings on the neuroprotective role of both SDF-1 and fractalkine, suggest that this novel interaction between the two chemokines may contribute to in vivo regulation of neuronal survival by modulating microglial neurotoxic properties. PMID:20124406

  13. Studies on Strong Interactions

    NASA Astrophysics Data System (ADS)

    Coriano, Claudio

    Five studies, four in Quantum field theory and one in fermionic molecular dynamics are presented. In the first study, introduced in chapter one and developed in chapter two of this dissertation, we formulate an extension of QCD sum rules to Compton scattering of the pion at intermediate energy. The chapter is based on the research paper Fixed angle pion Compton scattering and QCD sum rules by Prof. George Sterman and the author, which has been submitted for publication as a regular article. In chapter 3 we discuss the relation between traditional bosonic exchange models of nuclear strong interaction and soliton models, in the particular case of the sine-Gordon model. The chapter is based on the research paper "Scattering in soliton models and bosonic exchange descriptions", by R. R. Parwani, H. Yamagishi, I. Zahed and the author, and is published in Phys. Rev. D 45 (1992), 2542. A preprint of this paper (Preprint 1) has been included as an Appendix to the Chapter. In Chapter 4 we discuss aspects of the propagation of quantized fields in classical backgrounds, using the light-cone expansion of the propagator. The chapter is based on the research papers "Electrodynamics in the presence of an axion", published by the author in Modern Physics Letters A 7 (1992), 1253, and on the paper "Singularity of Green's function and the effective action in massive Yang Mills theories, by Prof. H. Yamagishi and the author. This last paper is published in Physical Review D 41 (1990), 3226 and its reprint appears in the final part of the Chapter (Reprint 1). In chapter 5, entitled "On the time dependent Rayleigh-Ritz equations", we discuss aspects of the variational approach to fermionic molecular dynamics. This investigation by R. Parwani, H. Yamagishi and the author has been published in Nucl. Physics A 522 (1991), 591. A preprint of this research paper has been inserted in the final part of the Chapter (Preprint 2).

  14. Nutrition and parasite interaction.

    PubMed

    Coop, R L; Holmes, P H

    1996-01-01

    This overview focuses on the interaction between nutritional status and gastrointestinal nematode infection in ruminants and considers: (i) the influence of the parasite on host metabolism; and (ii) the effect of host nutrition on the establishment and survival of parasite populations, the development of the host-immune response and the pathophysiology of infection. Gastrointestinal nematodes reduce voluntary feed intake and efficiency of feed utilisation, a key feature being an increased endogenous loss of protein into the gastrointestinal tract. Overall there is movement of protein from productive processes into repair of the gastrointestinal tract, synthesis of plasma proteins and mucoprotein production. Although reduction in feed intake is a major factor contributing to the reduced performance of parasitised ruminants, the underlying mechanisms of the anorexia are poorly understood. Supplementation of the diet with additional protein does not appear to affect initial establishment of nematode infections but the pathophysiological consequences are generally more severe on lower planes of protein nutrition. The main effect of protein supplementation is to increase the rate of acquisition of immunity and increase resistance to reinfection and this has been associated with an enhanced cellular immune response in the gastrointestinal mucosa. The unresponsiveness of the young lamb can be improved by dietary protein supplementation. Recent trials have shown that growing sheep offered a free choice between a low and a high protein ration are able to modify their diet selection in order to alleviate the increase in protein requirements which result from gastrointestinal nematode infection. Studies on the influence of nutrition on the expression of genotype have shown that the benefits of a superior genotype are not lost on a low protein diet whereas a high protein diet can partially emeliorate the disadvantages of an inferior genotype. In addition to dietary protein

  15. RIBOSOME-MEMBRANE INTERACTION

    PubMed Central

    Adelman, M. R.; Sabatini, David D.; Blobel, Günter

    1973-01-01

    In a medium of high ionic strength, rat liver rough microsomes can be nondestructively disassembled into ribosomes and stripped membranes if nascent polypeptides are discharged from the bound ribosomes by reaction with puromycin. At 750 mM KCl, 5 mM MgCl2, 50 mM Tris·HCl, pH 7 5, up to 85% of all bound ribosomes are released from the membranes after incubation at room temperature with 1 mM puromycin. The ribosomes are released as subunits which are active in peptide synthesis if programmed with polyuridylic acid. The ribosome-denuded, or stripped, rough microsomes (RM) can be recovered as intact, essentially unaltered membranous vesicles Judging from the incorporation of [3H]puromycin into hot acid-insoluble material and from the release of [3H]leucine-labeled nascent polypeptide chains from bound ribosomes, puromycin coupling occurs almost as well at low (25–100 mM) as at high (500–1000 mM) KCl concentrations. Since puromycin-dependent ribosome release only occurs at high ionic strength, it appears that ribosomes are bound to membranes via two types of interactions: a direct one between the membrane and the large ribosomal subunit (labile at high KCl concentration) and an indirect one in which the nascent chain anchors the ribosome to the membrane (puromycin labile). The nascent chains of ribosomes specifically released by puromycin remain tightly associated with the stripped membranes. Some membrane-bound ribosomes (up to 40%) can be nondestructively released in high ionic strength media without puromycin; these appear to consist of a mixture of inactive ribosomes and ribosomes containing relatively short nascent chains. A fraction (∼15%) of the bound ribosomes can only be released from membranes by exposure of RM to ionic conditions which cause extensive unfolding of ribosomal subunits, the nature and significance of these ribosomes is not clear. PMID:4682341

  16. Canadian Thesis Abstracts: Synthèse spectrale de jeunes populations stellaires dans; l'ultraviolet lointain

    NASA Astrophysics Data System (ADS)

    Pellerin, Anne

    2005-02-01

    Le but de cette thèse était de développer et tester la technique de synthè;se spectrale évolutive aux longueurs d'onde de l'ultraviolet lointain. Jusquà récemment, cette technique n'était appliqué quà des données au-delà de 1200 Å. Le lancement du satellite FUSE en 1999 a permis d'explorer le domaine de l'ultraviolet lointain (900-1200 Å) avec une grande résolution spectrale. J'ai donc utilisé les spectres du satellite FUSE de 228 étoiles chaudes de type O et B, de 24 galaxies à sursauts de formation d'étoiles et de quatre galaxies Seyfert. Dans un premier temps, j'ai caractérisé le comportement des profils de raies stellaires en fonction du type spectral, de la classe de luminosité et de la métallicité des étoiles. Les raies O vi >>1031.9, 1037.6, S iv >>1062.7, 1073.0, 1073.5, P v>>1118.0, 1128.0 et C iii >1175.6 ont été identifiées comme étant des indicateurs stellaires potentiellement intéressants pour la synthèse spectrale. Le domaine de longueur d'onde inférieur à 1000 Å couvert par FUSEmontre aussi des signatures stellaires mais qui sont peu intéressantes pour la synthèse en raison de la contamination interstellaire. J'ai ensuite crééé; une bibliothèque de spectres FUSE qui a été intégrée au code de synthèse LavalSBafin de produire des spectres de synthèse dans l'ultraviolet lointain pour diverses populations stellaires théoriques. Il s'est avéré que les raies de P vet de C iii sont d'excellents indicateurs d'âge, de métallicité et de fonction de masse initiale de la population stellaire, tandis que les raies de O vi et de S ivne sont pas aussi efficaces. La comparaison des spectres FUSEde galaxies avec les spectres synthétiques a révèlé des âges entre 2.5 et 18 millions d'années pour un large éventail de métallicités. On trouve aussi une forte dominance du mode instantané de formation stellaire. Ce travail a aussi permis d'estimer quantitativement l'extinction interne et les masses

  17. Conduction sous champ électrique faible dans les liquides isolants. Influence de la distance inter-électrodes

    NASA Astrophysics Data System (ADS)

    Touchard, G.; Chaar, S. Ai; Watanabe, S.; Borzeix, J.

    1991-07-01

    This study relates the phenomena of electric conduction in a dielectric liquid under a weak electric field. In the first part the equations of the diffuse layer perturbed by a weak electric field are established. The solutions are then computed numerically. It appears that one of the most important parameter is the space charge density appearing on the electrodes. This quantity is determined by streaming current experiments. In the second part, the experimental equipment is presented as well as the experiments. The liquid used is n heptane with several additives for different concentrations. The conductivity is measured in terms of the distance between the electrodes, the application time of the electric field and the additives concentration. We notice a sudden slope variation of the conductivity for a value of the concentration. The confrontation between experiments in terms of electrodes distance and the theoretical predictions is rather good. Dans cette étude, nous analysons les phénomènes de conduction électrique dans un liquide diélectrique soumis à un champ électrique faible entre deux électrodes planes parallèles. La première partie est une étude théorique dans laquelle nous présentons tout d'abord les équations générales de la couche diffuse correspondant au cas de la conduction sous champ électrique faible. La complexité des équations ne nous permet pas d'obtenir des solutions analytiques, mais nécessite un traitement numérique. Nous mettons alors en évidence qu'un des paramètres très importants est la densité volumique de charge apparaissant sur les électrodes. Ce paramètre conditionne le phénomène et il sera nécessaire de le déterminer par la mesure des courants d'écoulement. Dans la deuxième partie, nous présentons le dispositif expérimental utilisé ainsi que les résultats obtenus. Les expériences ont été faites avec de I'n heptane contenant un certain nombre d'additifs à des concentrations variables. La

  18. L'observance médicamenteuse et ses facteurs dans un groupe d'hypertendus congolais

    PubMed Central

    Ikama, Méo Stéphane; Nsitou, Bernice Mesmer; Loumouamou, Mpouoni; Kimbally-Kaky, Gisèle; Nkoua, Jean Louis

    2013-01-01

    L'objectif de ce travail était d’évaluer le niveau d'observance des patients hypertendus et identifier les facteurs prédictifs de mauvaise observance. Il s'est agi d'une étude transversale à recueil de données prospectif sur une période de six mois. Elle s'est déroulée dans les services de consultations externes de cardiologie dans trois hôpitaux: le CHU de Brazzaville, l'hôpital central des armées de Brazzaville, et l'hôpital général de Loandjili (Pointe-Noire). Cette étude a concerné 212 patients dont 122 femmes (57.5%) et 90 hommes (42.5%), âgés de plus de 18ans, hypertendus traités depuis au moins six mois. Le questionnaire à six questions conçu par Girerd a été utilisé pour évaluer l'observance médicamenteuse. Une régression logistique a été utilisée pour rechercher les facteurs de mauvaise observance. L'observance était considérée comme bonne chez 45 patients soit 21.2%, et mauvaise chez 69 patients soit 32.5%. Dans 98 cas soit 46.2% il y avait un minime problème d'observance. Une HTA ancienne de plus de 5 ans, la présence des complications évolutives de l'HTA ainsi que les niveaux élevés de la PAS et de la PAD étaient liés à la mauvaise observance. Par contre aucune relation statistique n'a été retrouvée entre la mauvaise observance et l'existence d'une co-morbidité, la fréquence des prises médicamenteuses, le nombre de comprimés par jour et une pression artérielle non contrôlée. Les patients non observant étaient en moyenne plus âgés que les autres. Une mauvaise connaissance du traitement et des complications de l'HTA, le fait de ne pas acheter soi-même ses médicaments, l'ignorance de la gravité de l'HTA, et le coût élevé du traitement étaient prédictifs d'une mauvaise observance. La possession d'un tensiomètre électronique d'auto mesure tensionnelle ainsi que le rappel des prises médicamenteuses par les parents étaient liés à une bonne observance. Après ajustement par une r

  19. Induction of matrix metalloprotease-1 gene expression by retinoic acid in the human pancreatic tumour cell line Dan-G

    PubMed Central

    Marschall, Z von; Riecken, E-O; Rosewicz, S

    1999-01-01

    We have investigated the effects of retinoic acid (RA) on matrix metalloprotease-1 (MMP-1) gene expression in the human pancreatic tumour cell line Dan-G. 13-cis RA results in a time- and dose-dependent increase of MMP-1 protein concentration. These stimulatory effects were paralleled by a time- and dose-dependent increase of MMP-1 mRNA steady-state concentrations. Nuclear run-on analysis revealed that the increase of MMP-1 mRNA was partially due to an increase of MMP-1 gene transcription. In addition, 13-cis RA treatment results in an increase of MMP-1 mRNA stability. These data demonstrate that RA stimulates MMP-1 gene expression in human pancreatic carcinoma cells by transcriptional and post-transcriptional mechanisms. © 1999 Cancer Research Campaign PMID:10362099

  20. Theoretical studies of molecular interactions

    SciTech Connect

    Lester, W.A. Jr.

    1993-12-01

    This research program is directed at extending fundamental knowledge of atoms and molecules including their electronic structure, mutual interaction, collision dynamics, and interaction with radiation. The approach combines the use of ab initio methods--Hartree-Fock (HF) multiconfiguration HF, configuration interaction, and the recently developed quantum Monte Carlo (MC)--to describe electronic structure, intermolecular interactions, and other properties, with various methods of characterizing inelastic and reaction collision processes, and photodissociation dynamics. Present activity is focused on the development and application of the QMC method, surface catalyzed reactions, and reorientation cross sections.