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Sample records for interessant le bloc

  1. Quand le bloc axillaire reste la seule alternative chez un enfant de 5 ans

    PubMed Central

    Nakhli, Mohamed Said; Béjaoui, Nawel; Naija, Walid; Mhamdi, Salah; Said, Rachid

    2015-01-01

    Le bloc axillaire par neurostimulation chez l'enfant n'est pas une technique habituelle, surtout avec le développement des techniques d'anesthésie locorégionale échoguidées. Cependant elle peut être une alternative intéressante si l'anesthésie générale est a risque voir même contre indiquée. Nous rapportons le cas d'un bloc axillaire anesthésique chez un enfant de 5 ans porteur d'un kyste hydatique du poumon et une hépatite A sévère proposé pour une fixation de fracture du condyle externe de l'humérus. PMID:26405472

  2. Nuclear power in the Soviet Bloc

    SciTech Connect

    Davey, W.G.

    1982-03-01

    The growth of Soviet Bloc nuclear power generation to the end of the century is evaluated on the basis of policy statements of objectives, past and current nuclear power plant construction, and trends in the potential for future construction. Central to this study is a detailed examination of individual reactor construction and site development that provides specific performance data not given elsewhere. A major commitment to nuclear power is abundantly clear and an expansion of ten times in nuclear electric generation is estimated between 1980 and 2000. This rate of growth is likely to have significant impact upon the total energy economy of the Soviet Bloc including lessening demands for use of coal, oil, and gas for electricity generation.

  3. Amelioration de l'efficacite energetique du procede d'electrolyse de l'aluminium conception d'un nouveau bloc cathodique

    NASA Astrophysics Data System (ADS)

    Blais, Mathieu

    Au Quebec, les alumineries sont de grandes consommatrices d'energie electrique, soit pres de 14 % de la puissance installee d'Hydro-Quebec. Dans ce contexte, des petits gains en efficacite energetique des cuves d'electrolyse pourraient avoir un impact important sur la reduction globale de la consommation d'electricite. Le projet de maitrise decrit dans cette etude repond a la problematique suivante : comment l'optimisation de la geometrie d'un bloc cathodique en vue d'uniformiser la densite de courant peut augmenter l'efficacite energetique et la duree de vie de la cuve d'aluminium? Le but premier du projet est de modifier la geometrie en vue d'ameliorer le comportement thermoelectrique des blocs cathodiques et d'accroitre par le fait meme l'efficacite energetique du procede de production d'aluminium. La mauvaise distribution de la densite de courant dans la cuve est responsable de certains problemes energetiques ayant des impacts negatifs sur l'economie et l'environnement. Cette non-uniformite de la distribution du courant induit une usure prematuree de la surface de la cathode et contribue a reduire la stabilite magnetohydrodynamique de la nappe de metal liquide. Afin de quantifier les impacts que peut avoir l'uniformisation de la densite de courant a travers le bloc cathodique, un modele d'un bloc cathodique d'une cuve de la technologie AP-30 a ete concu et analyse par elements finis. A partir de son comportement thermoelectrique et de donnees experimentales d'une cuve AP-30 tirees de la litterature, une correlation entre le profil de densite de courant a la surface du bloc et le taux d'erosion local au meme endroit a ete creee. Cette relation correspond au modele predictif de la duree de vie de tout bloc du meme materiau a partir de son profil de densite de courant. Ensuite, une programmation a ete faite incorporant dans une meme fonction cout les impacts economiques de la duree de vie, de la chute de voltage cathodique et de l'utilisation de nouveaux materiaux

  4. BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers.

    PubMed

    Dennis, Megan K; Delevoye, Cédric; Acosta-Ruiz, Amanda; Hurbain, Ilse; Romao, Maryse; Hesketh, Geoffrey G; Goff, Philip S; Sviderskaya, Elena V; Bennett, Dorothy C; Luzio, J Paul; Galli, Thierry; Owen, David J; Raposo, Graça; Marks, Michael S

    2016-08-01

    Endomembrane organelle maturation requires cargo delivery via fusion with membrane transport intermediates and recycling of fusion factors to their sites of origin. Melanosomes and other lysosome-related organelles obtain cargoes from early endosomes, but the fusion machinery involved and its recycling pathway are unknown. Here, we show that the v-SNARE VAMP7 mediates fusion of melanosomes with tubular transport carriers that also carry the cargo protein TYRP1 and that require BLOC-1 for their formation. Using live-cell imaging, we identify a pathway for VAMP7 recycling from melanosomes that employs distinct tubular carriers. The recycling carriers also harbor the VAMP7-binding scaffold protein VARP and the tissue-restricted Rab GTPase RAB38. Recycling carrier formation is dependent on the RAB38 exchange factor BLOC-3. Our data suggest that VAMP7 mediates fusion of BLOC-1-dependent transport carriers with melanosomes, illuminate SNARE recycling from melanosomes as a critical BLOC-3-dependent step, and likely explain the distinct hypopigmentation phenotypes associated with BLOC-1 and BLOC-3 deficiency in Hermansky-Pudlak syndrome variants. PMID:27482051

  5. En Bloc Resection of Solitary Functional Secreting Spinal Metastasis.

    PubMed

    Goodwin, C Rory; Clarke, Michelle J; Gokaslan, Ziya L; Fisher, Charles; Laufer, Ilya; Weber, Michael H; Sciubba, Daniel M

    2016-05-01

    Study Design Literature review. Objective Functional secretory tumors metastatic to the spine can secrete hormones, growth factors, peptides, and/or molecules into the systemic circulation that cause distinct syndromes, clinically symptomatic effects, and/or additional morbidity and mortality. En bloc resection has a limited role in metastatic spine disease due to the current paradigm that systemic burden usually determines morbidity and mortality. Our objective is to review the literature for studies focused on en bloc resection of functionally active spinal metastasis as the primary indication. Methods A review of the PubMed literature was performed to identify studies focused on functional secreting metastatic tumors to the spinal column. We identified five cases of patients undergoing en bloc resection of spinal metastases from functional secreting tumors. Results The primary histologies of these spinal metastases were pheochromocytoma, carcinoid tumor, choriocarcinoma, and a fibroblast growth factor 23-secreting phosphaturic mesenchymal tumor. Although studies of en bloc resection for these rare tumor subtypes are confined to case reports, this surgical treatment option resulted in metabolic cures and decreased clinical symptoms postoperatively for patients diagnosed with solitary functional secretory spinal metastasis. Conclusion Although the ability to formulate comprehensive conclusions is limited, case reports demonstrate that en bloc resection may be considered as a potential surgical option for the treatment of patients diagnosed with solitary functional secretory spinal metastatic tumors. Future prospective investigations into clinical outcomes should be conducted comparing intralesional resection and en bloc resection for patients diagnosed with solitary functional secretory spinal metastasis.

  6. En Bloc Resection of Solitary Functional Secreting Spinal Metastasis

    PubMed Central

    Goodwin, C. Rory; Clarke, Michelle J.; Gokaslan, Ziya L.; Fisher, Charles; Laufer, Ilya; Weber, Michael H.; Sciubba, Daniel M.

    2015-01-01

    Study Design Literature review. Objective Functional secretory tumors metastatic to the spine can secrete hormones, growth factors, peptides, and/or molecules into the systemic circulation that cause distinct syndromes, clinically symptomatic effects, and/or additional morbidity and mortality. En bloc resection has a limited role in metastatic spine disease due to the current paradigm that systemic burden usually determines morbidity and mortality. Our objective is to review the literature for studies focused on en bloc resection of functionally active spinal metastasis as the primary indication. Methods A review of the PubMed literature was performed to identify studies focused on functional secreting metastatic tumors to the spinal column. We identified five cases of patients undergoing en bloc resection of spinal metastases from functional secreting tumors. Results The primary histologies of these spinal metastases were pheochromocytoma, carcinoid tumor, choriocarcinoma, and a fibroblast growth factor 23–secreting phosphaturic mesenchymal tumor. Although studies of en bloc resection for these rare tumor subtypes are confined to case reports, this surgical treatment option resulted in metabolic cures and decreased clinical symptoms postoperatively for patients diagnosed with solitary functional secretory spinal metastasis. Conclusion Although the ability to formulate comprehensive conclusions is limited, case reports demonstrate that en bloc resection may be considered as a potential surgical option for the treatment of patients diagnosed with solitary functional secretory spinal metastatic tumors. Future prospective investigations into clinical outcomes should be conducted comparing intralesional resection and en bloc resection for patients diagnosed with solitary functional secretory spinal metastasis. PMID:27099819

  7. Theses on the Latino Bloc: A Critical Perspective

    ERIC Educational Resources Information Center

    Sanchez, Rosaura; Pita, Beatrice

    2006-01-01

    Increasing anxieties about the growing Latina/o population in the United States have fueled virulent xenophobia toward immigrants. This essay proposes the need to forge strategic political alliances by constructing this population as a bloc, a nexus of diverse groups that differ at the level of national origin, race, residential status, class,…

  8. Corruption Hierarchies in Higher Education in the Former Soviet Bloc

    ERIC Educational Resources Information Center

    Osipian, Ararat L.

    2009-01-01

    Corruption in higher education is known but not described theoretically. Decentralization and privatization of higher education and the increasing scale and scope of corruption in higher education in the former Soviet Bloc, as well as numerous other countries, urges better understanding of the problem within the context of socio-economic…

  9. Postoperative Cerebrospinal Fluid Leakage Associated With Total En Bloc Spondylectomy.

    PubMed

    Yokogawa, Noriaki; Murakami, Hideki; Demura, Satoru; Kato, Satoshi; Yoshioka, Katsuhito; Hayashi, Hiroyuki; Ishii, Takayoshi; Igarashi, Takashi; Fang, Xiang; Tsuchiya, Hiroyuki

    2015-07-01

    Cerebrospinal fluid (CSF) leakage is a serious postoperative complication associated with total en bloc spondylectomy. The authors examined the risk factors for CSF leakage after this procedure. A total of 72 patients underwent total en bloc spondylectomy at the authors' institution between May 2010 and April 2013. Postoperative CSF leakage was observed in 17 of the 72 patients (23.6%). The results of univariate analysis suggested that age 54 years or older, preoperative surgical site irradiation, resection of 3 or more vertebral bodies, and dural injury were significant risk factors for postoperative CSF leakage after total en bloc spondylectomy. Multivariate analysis showed that preoperative surgical site irradiation was the only significant risk factor for postoperative CSF leakage (adjusted odds ratio, 5.22; 95% confidence interval, 1.03-26.45, P=.046). The authors also assessed the course of treatment for postoperative CSF leakage in each patient. Of 17 patients with postoperative CSF leakage, 13 recovered without further complications, but 4 required reoperation (2 for wound dehiscence, 1 for surgical site infection, and 1 for severe intracranial hypotension). All 4 patients who required reoperation had a history of surgical site irradiation. Thus, this study suggests that careful consideration should be given to postoperative CSF leakage in patients with a history of surgical site irradiation. These findings may contribute to the management of postoperative CSF leakage associated with total en bloc spondylectomy and supplement the information given to the patient in the process of obtaining informed consent.

  10. Pediatric en bloc kidney transplantation into pediatric recipients.

    PubMed

    Lau, Keith K; Berg, Gerre M; Schjoneman, Yolanda G; Perez, Richard V; Butani, Lavjay

    2010-02-01

    As a result of the ongoing shortage in organ supply, en bloc renal transplantation from small donors has become more common for adult recipients with ESRD. However, because of concern for higher complication rates and sub-optimal outcomes, it is not being performed in every center, and data describing its use in pediatric recipients are even more limited. We retrospectively studied three patients who have undergone en bloc renal transplantation at our center. Median age at transplantation was 16.7 yr with a median follow-up of 1.2 yr. Donor age ranged from nine to 49 months with weight ranging from 10 to 22 kg. There were no post-operative thrombotic complications. All grafts showed increased renal size at follow-up by ultrasound. There was no clinical or histological rejection at last follow-up. To the best of our knowledge, this is the first report on the outcomes of en bloc kidney transplantation from pediatric donors into pediatric recipients. Based on our experience, albeit very limited, we feel that en bloc renal transplantation from young donors is an acceptable and safe procedure with low complication rates in pediatric recipients and should be given consideration to minimize wait times on the wait list and to improve quality of life.

  11. Total En Bloc Spondylectomy for Primary and Metastatic Spine Tumors.

    PubMed

    Mesfin, Addisu; El Dafrawy, Mostafa H; Jain, Amit; Hassanzadeh, Hamid; Kebaish, Khaled M

    2015-11-01

    This study reports the surgical and clinical outcomes of spinal tumors managed with total en bloc spondylectomy. The authors searched their prospectively maintained database for patients undergoing total en bloc spondylectomy between 2001 and 2013. Ten patients (9 men, 1 woman; average age, 50.7 years; range, 42-68 years) were identified. The authors obtained demographic information, surgical outcomes (estimated blood loss, complications), and clinical outcomes (recurrence, survival). All patients had pain and were classified as American Spinal Injury Association grade E. The lesions were located in the thoracic (8 patients) and lumbar (2 patients) spine. Anterior column reconstruction was performed with strut allograft (7 patients), mesh cage (2 patients), and polymethyl methacrylate (1 patient). An average of 2.3 (range, 2-4) of 6 portions of the vertebrae were involved, according to the Kostuik classification. Mean estimated blood loss, operative time, and hospital stay were 3.5 L, 500 minutes, and 7.8 days, respectively. Perioperative complications included pleural tear (2 patients) and aortic tear, vena cava tear, retained sponge, pulmonary embolism, urinary tract infection, pneumothorax, anterior column support failure, and prominent instrumentation requiring removal (1 patient each). Postoperatively, all patients remained classified as American Spinal Injury Association grade E. Two patients had recurrence at distant spinal segments, and 1 had a new lesion in the thigh. Five patients had died (mean, 34.5 months after surgery), and 5 were alive a mean of 19.6 months after surgery (range, 6-48 months). Total en bloc spondylectomy is challenging, but in appropriately selected patients, it can be used to treat primary and metastatic spinal lesions.

  12. Coming or going? Un-BLOC-ing delivery and recycling pathways during melanosome maturation.

    PubMed

    Futter, Clare E; Cutler, Daniel F

    2016-08-01

    Melanosome biogenesis requires successive waves of cargo delivery from endosomes to immature melanosomes, coupled with recycling of the trafficking machinery. Dennis et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201605090) report differential roles for BLOC-1 and BLOC-3 complexes in delivery and recycling of melanosomal biogenetic components, supplying directionality to melanosome maturation.

  13. The pathogenic mechanism of dysbindin-1B toxic aggregation: BLOC-1 and intercellular vesicle trafficking.

    PubMed

    Yang, Wei; Zhu, Chunyan; Shen, Yan; Xu, Qi

    2016-10-01

    DTNBP1, which encodes dysbindin-1, is associated with cognitive impairment. Genetic evidence indicates that the C allele of rs117610176 leads to an increase in DTNBP-1b mRNA splicing in patients with paranoid schizophrenia. In addition, dysbindin-1B, rather than dysbindin-1A/C, exhibits a tendency toward toxic aggregation. In postmortem brains, dysbindin-1B not only aggregates with itself, it also co-aggregates with proteins that interact with it. However, the pathogenic mechanism underlying dysbindin-1B toxic aggregation remains unknown. In the brain, dysbindin-1 is primarily found as a subunit of biogenesis of lysosome-related organelles complex 1 (BLOC-1), which plays a role in intracellular vesicle trafficking. Therefore, we hypothesized that dysbindin-1B might impair the cognitive function of schizophrenia patients by co-aggregating with BLOC-1 subunits and disturbing the function of BLOC-1. In this study, we investigated the dominant-negative effect of dysbindin-1B on the BLOC-1 complex. We found that in multiple brain areas in Dys1B(+/+) mice, the expression levels of soluble functional BLOC-1 subunits were decreased. Meanwhile, BLOC-1 subunits co-aggregated with dysbindin-1B-myc. Functional studies in primary cortical neurons further revealed the malfunction of BLOC-1 in intercellular vesicle trafficking in Dys1B(+/+) mice. In addition, we used the Morris water maze task to investigate the effects of dysbindin-1B aggregation on cognition. The results demonstrated that Dys1B(+/+) mice exhibited spatial learning and memory deficits, which were accompanied by the shrinkage of apical and basal dendritic branches and the loss of dendritic spines in hippocampal CA1 neurons, as demonstrated by Golgi staining. Taken together, the results of the present study suggest that dysbindin-1B toxic aggregation might impair cognition through a dominant-negative effect on BLOC-1.

  14. Functional interactions between OCA2 and the protein complexes BLOC-1, BLOC-2, and AP-3 inferred from epistatic analyses of mouse coat pigmentation.

    PubMed

    Hoyle, Diego J; Rodriguez-Fernandez, Imilce A; Dell'angelica, Esteban C

    2011-04-01

    The biogenesis of melanosomes is a multistage process that requires the function of cell-type-specific and ubiquitously expressed proteins. OCA2, the product of the gene defective in oculocutaneous albinism type 2, is a melanosomal membrane protein with restricted expression pattern and a potential role in the trafficking of other proteins to melanosomes. The ubiquitous protein complexes AP-3, BLOC-1, and BLOC-2, which contain as subunits the products of genes defective in various types of Hermansky-Pudlak syndrome, have been likewise implicated in trafficking to melanosomes. We have tested for genetic interactions between mutant alleles causing deficiency in OCA2 (pink-eyed dilution unstable), AP-3 (pearl), BLOC-1 (pallid), and BLOC-2 (cocoa) in C57BL/6J mice. The pallid allele was epistatic to pink-eyed dilution, and the latter behaved as a semi-dominant phenotypic enhancer of cocoa and, to a lesser extent, of pearl. These observations suggest functional links between OCA2 and these three protein complexes involved in melanosome biogenesis.

  15. Soft-tissue reconstruction after total en bloc sacrectomy.

    PubMed

    Kim, Jennifer E; Pang, John; Christensen, Joani M; Coon, Devin; Zadnik, Patricia L; Wolinsky, Jean-Paul; Gokaslan, Ziya L; Bydon, Ali; Sciubba, Daniel M; Witham, Timothy; Redett, Richard J; Sacks, Justin M

    2015-06-01

    OBJECT Total en bloc sacrectomy is a dramatic procedure that results in extensive sacral defects. The authors present a series of patients who underwent flap reconstruction after total sacrectomy, report clinical outcomes, and provide a treatment algorithm to guide surgical care of this unique patient population. METHODS After institutional review board approval, data were collected for all patients who underwent total sacrectomy between 2002 and 2012 at The Johns Hopkins Hospital. Variables included demographic data, medical history, tumor characteristics, surgical details, postoperative complications, and clinical outcomes. All subtotal sacrectomies were excluded. RESULTS Between 2002 and 2012, 9 patients underwent total sacrectomy with flap reconstruction. Diagnoses included chordoma (n = 5), osteoblastoma (n = 1), sarcoma (n = 2), and metastatic colon cancer (n = 1). Six patients received gluteus maximus (GM) flaps with a prosthetic rectal sling following a single-stage, posterior sacrectomy. Four required additional paraspinous muscle (PSM) or pedicled latissimus dorsi (LD) fasciocutaneous flaps. Three patients underwent multistage sacrectomy with an anterior-posterior approach, 2 of whom received pedicled vertical rectus abdominis myocutaneous (VRAM) flaps, and 1 of whom received local GM, LD, and PSM flaps. Flap complications included dehiscence (n = 4) and infection (n = 1). During the 1st year of follow-up, 2 of 9 patients (22%) were able to ambulate with an assistive device by the 1st postoperative month, and 6 of 9 (67%) were ambulatory with a walker by the 3rd postoperative month. By postoperative Month 12, 5 of 9 patients (56%)-or 5 of 5 patients not lost to follow-up (100%)-were able to able to ambulate independently. CONCLUSIONS The authors' experience suggests that the GM and pedicled VRAM flaps are reliable options for softtissue reconstruction of total sacrectomy defects. For posterior-only operations, GM flaps with or without a prosthetic rectal

  16. Computer-Assisted Navigation During an Anterior-Posterior En Bloc Resection of a Sacral Tumor.

    PubMed

    Al Eissa, Sami; Al-Habib, Amro F; Jahangiri, Faisal R

    2015-11-04

    Previously, a computer-based navigation system has not been used routinely for en-bloc resection of sacral tumors. In order to improve the accuracy of tumor resection, O-arm navigation was used to join anterior and posterior osteotomies during an en-bloc resection of a sacral Ewing's sarcoma. This case study describes the technique for en-bloc resection of a sacral Ewing's sarcoma guided by O-arm computer navigation and intraoperative neurophysiological monitoring (IONM). An 18-year-old male presented with weakness in his left lower extremity. MRI of the patient's spine showed a sacral mass causing compression of left S1 and S2 roots. A surgical resection was planned with anterior and posterior approaches. An O-arm computer navigation system was used to assist in meeting anterior osteotomy cuts with the posterior cuts to ensure complete resection of the sacral tumor with a safe margin. Computer-assisted navigation was used along with IONM during this procedure to help guide the surgical team in an adequate tumor resection. There were no complications related to the use of the O-arm or the navigation system. Computer navigation guidance is both useful and safe in sacral tumor resections. It enhanced the accuracy of the en-bloc removal of a sacral tumor with safe margins while protecting neural function and minimizing recurrence.

  17. Human Capital--Economic Growth Nexus in the Former Soviet Bloc

    ERIC Educational Resources Information Center

    Osipian, Ararat L.

    2007-01-01

    This study analyses the role and impact of higher education on per capita economic growth in the Former Soviet Bloc. It attempts to estimate the significance of educational levels for initiating substantial economic growth that now takes place in these two countries. This study estimates a system of linear and log-linear equations that account for…

  18. BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes.

    PubMed

    Delevoye, Cédric; Heiligenstein, Xavier; Ripoll, Léa; Gilles-Marsens, Floriane; Dennis, Megan K; Linares, Ricardo A; Derman, Laura; Gokhale, Avanti; Morel, Etienne; Faundez, Victor; Marks, Michael S; Raposo, Graça

    2016-01-11

    Recycling endosomes consist of a tubular network that emerges from vacuolar sorting endosomes and diverts cargoes toward the cell surface, the Golgi, or lysosome-related organelles. How recycling tubules are formed remains unknown. We show that recycling endosome biogenesis requires the protein complex BLOC-1. Mutations in BLOC-1 subunits underlie an inherited disorder characterized by albinism, the Hermansky-Pudlak Syndrome, and are associated with schizophrenia risk. We show here that BLOC-1 coordinates the kinesin KIF13A-dependent pulling of endosomal tubules along microtubules to the Annexin A2/actin-dependent stabilization and detachment of recycling tubules. These components cooperate to extend, stabilize and form tubular endosomal carriers that function in cargo recycling and in the biogenesis of pigment granules in melanocytic cells. By shaping recycling endosomal tubules, our data reveal that dysfunction of the BLOC-1-KIF13A-Annexin A2 molecular network underlies the pathophysiology of neurological and pigmentary disorders. PMID:26725201

  19. A comparison of cyst wall curettage and en bloc excision in the treatment of aneurysmal bone cysts

    PubMed Central

    2013-01-01

    Background The recurrence rate after aneurysmal bone cyst (ABC) treatment is quite high despite its benign nature. In ABC therapy, curettage is the treatment of choice; en bloc excision results in a lower recurrence rate, but more extensive reconstructive surgery is needed with associated morbidity. The aim of the present study was to compare the outcomes of the two treatment options. Methods A retrospective analysis was performed on 26 patients treated for ABCs: 16 by curettage and 10 by en bloc excision. Each lesion was classified according to Enneking and patients were followed up for a mean time of 9.2 years. On follow-up, radiological examination and functional assessment (range of motion, muscle strength) were performed. Recurrence was defined as the presence of an osteolytic lesion, especially one with a tendency to grow. Results On follow-up, the following symptoms were more prevalent in the en bloc excision group compared to the curettage group: pain (en bloc 20% versus curettage 6.25%), limb length differences (en bloc 20% versus curettage 12.5%), reduced range of motion (en bloc 20% versus curettage 6.25%) and muscle strength impairment (en bloc 50% versus curettage 31.2%); however, the differences were not statistically significant (P >0.05). In the curettage group, two cases of postoperative complications and two cases of recurrence were seen, while in the en bloc excision group one case of complications was noted. Conclusions Curettage is a standard procedure in ABC management. En bloc excision is another option, albeit more technically demanding, that may be considered in recurrent lesions with extensive bone destruction or for cysts in an expendable location. PMID:23701661

  20. Distal pancreatectomy: en-bloc splenectomy vs spleen-preserving pancreatectomy

    PubMed Central

    Orduña, David; Cesar-Borges, Gleydson; Angel López-Boado, Miguel

    2005-01-01

    Distal pancreatectomy with en-bloc splenectomy has been considered the standard technique for management of benign and malignant pancreatic disorders. However, splenic preservation has recently been advocated. The aim of this study was to review the experiences of distal pancreatectomy using the open or the laparoscopic approach and to critically discuss the need to perform splenectomy. Original articles published in the English literature of peer-reviewed medical journals were selected for detailed analysis. In patients with malignant neoplasms in the body-tail of the pancreas, splenectomy has a negative influence on long-term survival after resection. The incidence of diabetes after spleen-preserving distal pancreatectomy for chronic pancreatitis is less than after en-bloc splenectomy. Spleen salvage eliminates the risk of overwhelming infections. Laparoscopic spleen-preserving distal pancreatectomy is feasible and safe. Laparoscopic spleen-preserving distal pancreatectomy may be preferable for the advantages of a minimally invasive approach. PMID:18333170

  1. Autotransplantation of Immature Third Molars and Orthodontic Treatment After En Bloc Resection of Conventional Ameloblastoma.

    PubMed

    Osterne, Rafael Lima Verde; Moreira Neto, José Jeová Siebra; de Araújo Lima, Augusto Darwin Moreira; Nogueira, Renato Luiz Maia

    2015-09-01

    Ameloblastoma treatment can lead to significant bone defects; consequently, oral rehabilitation can be challenging. We present the case of a 14-year-old girl diagnosed with a conventional ameloblastoma in the mandible who was treated using en bloc resection and rehabilitated with autotransplantation of the immature third molars and orthodontic treatment. The lesion was in the region of the lower left canine and premolars, and en bloc resection resulted in a significant alveolar bone defect. Autotransplantation of the lower third molars to the site of the lower left premolars was performed. After 2 years, the upper left third molar was transplanted to the site of the lower left canine. During the orthodontic treatment period, considerable alveolar bone formation was observed in the region of the transplanted teeth, and roots developed. To the best of our knowledge, this is the first reported case of alveolar bone formation induction caused by tooth transplantation after ameloblastoma treatment. PMID:26044604

  2. Validity and reliability of the Greek version of Brown's locus of control scale (BLOCS).

    PubMed

    Papanikolaou, Vicky; Tyrovola, Konstantina; Adamis, Dimitrios

    2012-12-01

    Studies in different research fields have shown that locus of control is a meaningful concept. A translated measurement of locus of control in Greece is the Brown locus of control scale (BLOCS), but the translation has not been yet validated. Construct validity and reliability of the BLOCS Greek version was investigated in a sample of employees in five public institutions. Three dimensions identified in the original study were observed. A reduced scale of 20 items showed better psychometric properties: Cronbach's alphas were for the total scale .76 (McDonald's omega = .72), and internal .76, external social .73, and external other .73, comparable to the original and improved if 5 items are removed. PMID:23402054

  3. High contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy

    PubMed Central

    Tapia, Juan C.; Kasthuri, Narayanan; Hayworth, Kenneth; Schalek, Richard; Lichtman, Jeff W.; Smith, Stephen J; Buchanan, JoAnn

    2013-01-01

    Conventional heavy metal post staining methods on thin sections lend contrast but often cause contamination. To avoid this problem, we tested several en bloc staining techniques to contrast tissue in serial sections mounted on solid substrates for examination by Field Emission Scanning Electron Microscope (FESEM). Because FESEM section imaging requires that specimens have higher contrast and greater electrical conductivity than transmission electron microscope (TEM) samples, our technique utilizes osmium impregnation (OTO) to make the samples conductive while heavily staining membranes for segmentation studies. Combining this step with other classic heavy metal en bloc stains including uranyl acetate, lead aspartate, copper sulfate and lead citrate produced clean, highly contrasted TEM and SEM samples of insect, fish, and mammalian nervous system. This protocol takes 7–15 days to prepare resin embedded tissue, cut sections and produce serial section images. PMID:22240582

  4. High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy.

    PubMed

    Tapia, Juan Carlos; Kasthuri, Narayanan; Hayworth, Kenneth J; Schalek, Richard; Lichtman, Jeff W; Smith, Stephen J; Buchanan, JoAnn

    2012-02-01

    Conventional heavy metal poststaining methods on thin sections lend contrast but often cause contamination. To avoid this problem, we tested several en bloc staining techniques to contrast tissue in serial sections mounted on solid substrates for examination by field emission scanning electron microscopy (FESEM). Because FESEM section imaging requires that specimens have higher contrast and greater electrical conductivity than transmission electron microscopy (TEM) samples, our technique uses osmium impregnation (OTO) to make the samples conductive while heavily staining membranes for segmentation studies. Combining this step with other classic heavy metal en bloc stains, including uranyl acetate (UA), lead aspartate, copper sulfate and lead citrate, produced clean, highly contrasted TEM and scanning electron microscopy (SEM) samples of insect, fish and mammalian nervous systems. This protocol takes 7-15 d to prepare resin-embedded tissue, cut sections and produce serial section images. PMID:22240582

  5. Bladder sparing robot-assisted laparoscopic en bloc resection of urachus and umbilicus for urachal adenocarcinoma.

    PubMed

    Aoun, Fouad; Peltier, Alexandre; van Velthoven, Roland

    2015-06-01

    Urachal adenocarcinoma is a rare and aggressive form of bladder cancer that arises from the urachus. An en bloc resection of the urachus and umbilicus is recommended with either a total or partial cystectomy. However, there is no standard laparoscopic or robotic surgical technique for the operative management of these tumors. In the present report, we describe our robotic-assisted laparoscopic technique for the treatment of a primary malignant urachal tumor. PMID:26531120

  6. En bloc resection of a C2–C3 upper cervical chordoma: Technical note

    PubMed Central

    Weil, Alexander G.; Shehadeh, Mohammed; Ayad, Tareck; Abboud, Olivier; Shedid, Daniel

    2015-01-01

    Background: Recently, en bloc spondylectomy for upper cervical chordomas has been reported. Most authors utilize the combined approaches (e.g., transoral tumor resection with anterior column reconstruction and primary pharyngeal closure without up-front flap repair). However, the 60% incidence of posterior pharyngeal wall dehiscence delays oral intake, typically requires an additional surgery (e.g. free-flap), and delays radiation therapy. Methods: Here, we demonstrate the efficacy of en bloc C2–C3 spondylectomy for the treatment of upper cervical chordomas utilizing a combined transoral followed by posterior approach. We used a novel anterior de-epithelialized submental island flap (SIF) as an underlay graft between the pharyngeal wall and cage/hardware to prevent pharyngeal wound dehiscence. Results: Despite a small pharyngeal fistula, the construct healed and the patient was disease-free 40 months later. Conclusion: En bloc C2–C3 spondylectomy for the treatment of an upper cervical chordoma typically requires a combined transoral and posterior approaches. This required utilization of an anterior SIF to promote adequate wound healing. This maneuver avoided incurring the typical complications of combined approaches (e.g. transoral tumor resection with anterior column reconstruction and primary pharyngeal closure without up-front flap repair). PMID:26693391

  7. Risk factors for local recurrence after en bloc endoscopic submucosal dissection for early gastric cancer

    PubMed Central

    Lee, Ju Yup; Cho, Kwang Bum; Kim, Eun Soo; Park, Kyung Sik; Lee, Yoo Jin; Lee, Yoon Suk; Jang, Byoung Kuk; Chung, Woo Jin; Hwang, Jae Seok

    2016-01-01

    AIM: To investigate factors related to recurrence following en bloc resection using endoscopic submucosal dissection (ESD) in patients with early gastric cancer (EGC). METHODS: A total of 1121 patients (1215 lesions) who had undergone ESD for gastric neoplasia between April 2003 and May 2010 were retrospectively reviewed. Data from 401 patients (415 lesions) were analyzed, following the exclusion of those who underwent piecemeal resection, with deep resection margin invasion or lateral margin infiltration, and diagnosed with benign lesions. RESULTS: Local recurrence after en bloc ESD was found in 36 cases (8.7%). Unclear resection margins, long procedure times, and narrow safety margins were identified as risk factors for recurrence. Lesions located in the upper third of the stomach showed a higher rate of recurrence than those located in the lower third of the stomach (OR = 2.9, P = 0.03). The probability of no recurrence for up to 24 mo was 79.9% in those with a safety resection margin ≤ 1 mm and 89.5% in those with a margin > 1 mm (log-rank test, P = 0.03). CONCLUSION: Even in cases in which en bloc ESD is performed for EGC, local recurrence still occurs. To reduce local recurrences, more careful assessment will be needed prior to the implementation of ESD in cases in which the tumor is located in the upper third of the stomach. In addition, clear identification of tumor boundaries as well as the securing of sufficient safety resection margins will be important. PMID:27076871

  8. Quantitative Proteomic and Genetic Analyses of the Schizophrenia Susceptibility Factor Dysbindin Identify Novel Roles of the BLOC-1 Complex

    PubMed Central

    Gokhale, Avanti; Larimore, Jennifer; Werner, Erica; So, Lomon; De Luca, Andres Moreno; Lese-Martin, Christa; Lupashin, Vladimir V.; Smith, Yoland; Faundez, Victor

    2012-01-01

    The Biogenesis of Lysosome-Related Organelles Complex 1 (BLOC-1) is a protein complex containing the schizophrenia susceptibility factor dysbindin, which is encoded by the gene DTNBP1. However, mechanisms engaged by dysbindin defining schizophrenia susceptibility pathways have not been quantitatively elucidated. Here, we discovered prevalent and novel cellular roles of the BLOC-1 complex in neuronal cells by performing large-scale Stable Isotopic Labeling of Cells in Culture quantitative proteomics (SILAC) combined with genetic analyses in dysbindin-null mice (Mus musculus) and the genome of schizophrenia patients. We identified 24 proteins that associate with the BLOC-1 complex many of which were altered in content/distribution in cells or tissues deficient in BLOC-1. New findings include BLOC-1 interactions with the COG complex, a Golgi apparatus tether, and antioxidant enzymes peroxiredoxins 1-2. Importantly, loci encoding eight of the 24 proteins are affected by genomic copy number variation in schizophrenia patients. Thus, our quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility. PMID:22423091

  9. Le Fort IV + I distraction osteogenesis using an internal device for syndromic craniosynostosis.

    PubMed

    Sakamoto, Yoshiaki; Nakajima, Hideo; Tamada, Ikkei; Sakamoto, Teruo

    2014-04-01

    Monobloc and Le Fort III distractions can improve midfacial hypoplasia, a characteristic feature of syndromic craniosynostosis. The purpose of treating midfacial hypoplasia is to improve exophthalmos and dental occlusion. Typically, in Le Fort III or monobloc distractions, the midface is mobilized en bloc, and the extent and direction of the mobilization is determined according to the preferred intermaxillary occlusion. However, to obtain the preferred functional and esthetic results while correcting midface hypoplasia, the most sensible approach is the use of different degrees of mobilization and vectors for the upper and lower halves of the midface. This report describes the case of an adolescent with Crouzon syndrome showing frontal recession exophthalmos and an anterior crossbite. His condition was treated with monobloc minus Le Fort I and Le Fort I distraction using only internal devices, which the authors have designated Le Fort IV plus I distraction.

  10. Non-intubated simultaneous en bloc resection of pulmonary nodule and rib chondrosarcoma

    PubMed Central

    Zhang, Miao; Wang, Heng; Wu, Wenbin; Liu, Dong; Li, Min; Hu, Zhengqun

    2016-01-01

    Adequate surgical resection was required for patients with rib chondrosarcoma. A 61-year-old woman was presented with a palpable chest wall mass. Computed tomography (CT) of the chest revealed an isolated pulmonary nodule about 0.9 cm, and a giant rib tumor about 12 cm × 9 cm which penetrated through the 7th rib into thorax. CT reconstruction and simulated surgery was utilized for disease-free surgical margin (R0 resection), then a simultaneous en bloc resection of pulmonary nodule and rib tumor was performed along with chest wall reconstruction under local anesthesia and intravenous sedation without endotracheal intubation. And the recovery was encouragingly uneventful. PMID:27761448

  11. En bloc resection of huge cemento-ossifying fibroma of mandible: avoiding lower lip split incision.

    PubMed

    Ayub, Tahera; Katpar, Shahjahan; Shafique, Salman; Mirza, Talat

    2011-05-01

    Cemento-ossifying Fibroma (COF) is an osteogenic benign neoplasm affecting the jaws and other craniofacial bones. It commonly presents as a progressively slow growing pathology, which can sometimes attain an enormous size, causing facial deformity. A case of a huge cemento-ossifying fibroma, appearing as a mandibular dumbell tumour in a male patient is documented, which caused massive bone destruction and deformity. It was surgically removed by performing en bloc resection of mandible avoiding the splitting of lower lip incision technique, thereby maintaining his normal facial appearance.

  12. Large-volume en-bloc staining for electron microscopy-based connectomics

    PubMed Central

    Hua, Yunfeng; Laserstein, Philip; Helmstaedter, Moritz

    2015-01-01

    Large-scale connectomics requires dense staining of neuronal tissue blocks for electron microscopy (EM). Here we report a large-volume dense en-bloc EM staining protocol that overcomes the staining gradients, which so far substantially limited the reconstructable volumes in three-dimensional (3D) EM. Our protocol provides densely reconstructable tissue blocks from mouse neocortex sized at least 1 mm in diameter. By relaxing the constraints on precise topographic sample targeting, it makes the correlated functional and structural analysis of neuronal circuits realistic. PMID:26235643

  13. Results of en bloc resection for hepatocellular carcinoma extending to adjacent organs

    PubMed Central

    Zhou, Yan-Ming; Sui, Cheng-Jun; Li, Bin; Xu, Feng; Kan, Tong; Yang, Jia-Mei

    2012-01-01

    Background To curatively resect hepatocellular carcinoma (HCC) with adjacent organ extension, the combined resection of these organs is inevitable. We analyzed the safety and effectiveness of en bloc resection for HCC extending to adjacent organs. Methods From December 2002 to May 2006, we compared the surgical outcomes of patients with HCC extending to adjacent organs with those of closely matched, randomly selected patients with HCC without adjacent organ extension. Results We included 42 patients whose HCC extended to adjacent organs and 126 patients whose HCC did not extend to adjacent organs. There was no significant difference in survival, operative morbidity or mortality between the groups. In patients with HCC extending to adjacent organs, histopathological examination of the specimen revealed true tumour invasion in 13 and adhesion in 29 patients. Those with tumour invasion were more likely to have a high incidence of capsule infiltration, microvascular invasion and early intrahepatic recurrence (≤ 1 yr after hepatectomy). The 5-year overall survival of patients with tumour invasion was 11.5%, whereas that of patients with tumour adhesion was 38.1% (p = 0.033). Conclusion En bloc resection is a safe and effective therapy for HCC extending to adjacent organs. Tumour invasion to adjacent organs exhibits a more aggressive clinical behaviour and is associated with worse survival than tumour adhesion. PMID:22617536

  14. Laparoscopic Transvesical Resection of an En Bloc Bladder Cuff and Distal Ureter during Nephroureterectomy

    PubMed Central

    Giannakopoulos, Stilianos; Toufas, George; Dimitriadis, Charalampos; Giannopoulos, Stavros; Kalaitzis, Christos; Bantis, Athanasios; Patris, Emmanuel; Touloupidis, Stavros

    2012-01-01

    Objective. The most appropriate technique for excising the distal ureter and bladder cuff during laparoscopic nephroureterectomy is still debated. We report our experience with a pure laparoscopic transvesical method that duplicates the long-standing open transvesical approach. Materials and Methods. Seven men and three women diagnosed with upper tract transitional cell carcinoma were treated with this procedure. Three intravesical ports were inserted, and pneumovesicum was established at 12 mmHg. Transvesical laparoscopic circumferential detachment of the bladder cuff and en bloc mobilization of the last centimeters of the distal ureter were performed, followed by the closure of the bladder defect. Subsequently, a nephrectomy was performed either laparoscopically or using an open flank approach. Results. The median age was 68.5 years. The procedure was completed uneventfully in all cases. The median operating time for distal ureter excision was 82.5 minutes (range 55–120). No complications directly related to the pneumovesicum method were recorded. The median follow-up period was 31 months (range 12–55). During the follow-up period, two patients (20%) died from the disease, and a bladder tumor developed in three cases (30%). Conclusion. The laparoscopic transvesical resection of the en bloc bladder cuff and distal ureter is a reliable, effective, and oncologically safe technique, at least in the midterm. PMID:23049475

  15. Underwater endoscopic mucosal resection: The third way for en bloc resection of colonic lesions?

    PubMed Central

    Radaelli, Franco; Spinzi, Giancarlo

    2015-01-01

    Background Underwater endoscopic mucosal resection without submucosal injection has been described for removing large flat colorectal lesions. Objective We aim to evaluate the reproducibility of this technique in terms of ease of implementation, safety and efficacy. Methods A prospective observational study of consecutive underwater endoscopic mucosal resection in a community hospital was performed. Results From September 2014 to April 2015, 25 flat or sessile colorectal lesions (median size 22.8 mm, range 10–50 mm; 18 placed in the right colon) were removed in 25 patients. Two of the lesions were adenomatous recurrences on scar of prior resection and one was a recurrence on a surgical anastomosis. The resection was performed en bloc in 76% of the cases. At the pathological examination, 14 lesions (56%) had advanced histology and seven (28%) were sessile serrated adenomas (two with high-grade dysplasia). Complete resection was observed in all the lesions removed en bloc. Intra-procedural bleeding was observed in two cases; both were managed endoscopically and were uneventful. No major adverse events occurred. Conclusion Underwater endoscopic mucosal resection appears to be an easy, safe and effective technique in a community setting. Further studies evaluating the efficacy of the technique (early and late recurrence), as well as comparing it with traditional mucosal resection, are warranted. PMID:27536370

  16. En bloc transurethral resection of bladder lesions: a trick to retrieve specimens up to 4.5 cm.

    PubMed

    Naselli, Angelo; Introini, Carlo; Germinale, Francesco; Spina, Bruno; Puppo, Paolo

    2012-03-01

    The present technique maintains the integrity of voluminous lesions during extraction. Pathological analysis is consequently improved and a proper evaluation of the surgical margins is also possible. Papillary lesions of up to 4.5 cm are amenable to en bloc resection and extraction, while solid lesions comply less well with the urethra and sometimes are very difficult to extract. Nevertheless, the main limitation of the technique remains that lesions originating from the bladder neck are not amenable to en bloc resection,while particular attention should be paid during resection of lesions involving the ureteric orifice to avoid ureteric stripping.

  17. Assembly of the Biogenesis of Lysosome-related Organelles Complex-3 (BLOC-3) and Its Interaction with Rab9*

    PubMed Central

    Kloer, Daniel P.; Rojas, Raul; Ivan, Viorica; Moriyama, Kengo; van Vlijmen, Thijs; Murthy, Namita; Ghirlando, Rodolfo; van der Sluijs, Peter; Hurley, James H.; Bonifacino, Juan S.

    2010-01-01

    The Hermansky-Pudlak syndrome (HPS) is a genetic hypopigmentation and bleeding disorder caused by defective biogenesis of lysosome-related organelles (LROs) such as melanosomes and platelet dense bodies. HPS arises from mutations in any of 8 genes in humans and 16 genes in mice. Two of these genes, HPS1 and HPS4, encode components of the biogenesis of lysosome-related organelles complex-3 (BLOC-3). Herein we show that recombinant HPS1-HPS4 produced in insect cells can be efficiently isolated as a 1:1 heterodimer. Analytical ultracentrifugation reveals that this complex has a molecular mass of 146 kDa, equivalent to that of the native complex and to the sum of the predicted molecular masses of HPS1 and HPS4. This indicates that HPS1 and HPS4 interact directly in the absence of any other protein as part of BLOC-3. Limited proteolysis and deletion analyses show that both subunits interact with one another throughout most of their lengths with the sole exception of a long, unstructured loop in the central part of HPS4. An interaction screen reveals a specific and strong interaction of BLOC-3 with the GTP-bound form of the endosomal GTPase, Rab9. This interaction is mediated by HPS4 and the switch I and II regions of Rab9. These characteristics indicate that BLOC-3 might function as a Rab9 effector in the biogenesis of LROs. PMID:20048159

  18. En bloc joystick reduction of a comminuted intra-articular distal radius fracture: a technical trick.

    PubMed

    Siegall, Evan; Ziran, Bruce

    2014-08-01

    A patient with a 1-month-old intra-articular distal radius fracture (treated closed in a splint) presented with an unacceptable degree of pain and stiffness caused by shortening and dorsal angulation of the distal radius. The fracture was comminuted with 4 or 5 distinct fragments, several involving the articular surface. Surgical correction was attempted. During the procedure, it was noted that, though the distal radius was shortened and angulated, there was actually acceptable congruity of the articular surface itself, despite the intra-articular nature of the fracture. Bone quality was poor and healing incomplete. Thus, we were concerned the currently congruous articular surface would fall apart with manipulation. Given this situation, we used a unique scaffolding technique with Kirschner wires placed in perpendicular fashion to both hold the articular surface intact and manipulate it en bloc. This technique is a simple way to turn a complex fracture into an easily reduced 2-part fracture.

  19. Extracorporeal shockwave lithotripsy of ureteral stone in a patient with en bloc kidney transplantation: a case report.

    PubMed

    Markic, D; Valencic, M; Grskovic, A; Spanjol, J; Sotosek, S; Fuckar, Z; Maricic, A; Pavlovic, I; Budiselic, B

    2011-06-01

    We report a case of ureterolithiasis in a patient with an en bloc kidney transplantation, using extracorporeal shockwave lithotripsy (ESWL). The patient presented with asymptomatic macrohematuria. Computed tomography revealed a ureteral calculus just below the pyeloureteral junction with hydronephrosis of the medially positioned kidney. Took two sessions of ESWL were required for complete disintegration of the stone. At 3 years after successful treatment, the patient has an excellent functioning and stone-free graft.

  20. OELs derivation in Poland and in the former Eastern Bloc with reference to approaches and practices applied in the EU.

    PubMed

    Soćko, Renata; Czerczak, Sławomir; Kupczewska-Dobecka, Małgorzata

    2015-01-01

    Based on the literature, current legislation and the European Union (EU) directives, the rules to protect the health of workers in Poland and the countries of the former Eastern Bloc were analyzed. Since 2002, the activities in the field of hygiene standards in the countries of the former Eastern Bloc have been correlated with the EU policy. The functioning of the system of maximum admissible concentrations (MAC) having been implemented in Poland for many years before the accession to the EU, has provided for a relatively quick adjustment of Polish regulations on chemicals to the relevant European law. The Polish list includes 543 substances. In the former Eastern Bloc countries, intensification of work after joining the EU has caused the lists in those countries to contain from 285 substances in Slovakia to 780 in Lithuania. Currently, all substances included in the EU lists (up to and including the 3rd list of occupational exposure limit values of the Directive 2009/161/EC) have been governed by the Polish, Lithuanian, Czech, Latvian and Hungarian law. In Estonia and Slovakia the provisions of the Directive 2006/15/EC establishing the second list of occupational exposure limits have been implemented. Individual national lists contain much more chemicals than the EU list containing currently 122 substances. The legislative process in the EU is slow, and that is why the national law is important and necessary due to the local needs in selected areas. It is necessary to correlate the activities in the field of determining regional occupational exposure limit (OEL) values in the countries of the Eastern Bloc and the EU.

  1. Robotic-assisted partial cystectomy with en bloc excision of the urachus and the umbilicus for urachal adenocarcinoma.

    PubMed

    Correa, Jose J; Hakky, Tariq S; Spiess, Philippe E; Chuang, Tian; Sexton, Wade J

    2010-01-01

    We report two cases of urachal adenocarcinoma managed with robotic-assisted partial cystectomy. A detailed description of the robotic technique including methods used to resect the tumor, urachus, and umbilicus en bloc is described. A review of the management of urachal adenocarcinoma is presented. The robotic approach is technically feasible and safe, and is an attractive alternative to traditional open or laparoscopic-assisted partial cystectomy for this uncommon genitourinary malignancy. PMID:27628636

  2. Lacrimal gland adenoid cystic carcinoma: intracranial and extracranial en bloc resection.

    PubMed

    Marsh, J L; Wise, D M; Smith, M; Schwartz, H

    1981-10-01

    Adenoid cystic carcinoma of the lacrimal gland is a rare tumor, although it is the malignancy most frequently arising in the gland. Treatment has been unsuccessful generally, with a 15-year survival of less than 20 percent. Our experience with this tumor in a 61-year-old woman has led to a proposal for therapeutic management based on awareness of the lesion's natural history, an understanding of regional anatomy, and familiarity with therapies reported in the literature. The feasibility of adequate tumor ablation is determined from preoperative evaluation, including CT scan, initial exploratory craniotomy, and frozen-section examination of the cranial nerves transversing the orbit. Once resectability is confirmed, "curative" intracranial and extracranial en bloc resection is performed, including the tumor, the lacrimal gland, and all contiguous structures. The defect is immediately resurfaced with and "ice cream cone" forehead flap in anticipation of adjuvant radiotherapy. An orbital prosthesis is fitted as soon as the radiation reaction subsides, and a postablative CT scan is obtained as the baseline for follow-up. It remains to be seen whether this application of the technology of CT scanning and the techniques of craniofacial surgery will improve the prognosis for adenoid cystic carcinoma arising in the lacrimal gland. PMID:6269133

  3. Case Report: En Bloc Resection of Pancoast Tumor with Adjuvant Aortic Endograft and Chemoradiation

    PubMed Central

    Lu, Tony; Fischer, Uwe M.; Marco, Rex A.; Naoum, Joseph J.; Reardon, Michael J.; Lumsden, Alan B.; Blackmon, Shanda H.; Davies, Mark G.

    2015-01-01

    “Pancoast” tumors frequently require a multidisciplinary approach to therapy and are still associated with high morbidity and mortality. Due to their sensitive anatomic location, complex resections and chemoradiation regimens are typically required for treatment. Those with signs of aortic invasion pose an even greater challenge, given the added risks of cardiopulmonary bypass for aortic resection and interposition. Placement of an aortic endograft can facilitate resection if the tumor is in close proximity to or is invading the aorta. Prophylactic endografting to prevent radiation-associated aortic rupture has also been described. This case describes a 60-year-old female who presented with a stage IIIa left upper lobe undifferentiated non-small-cell carcinoma encasing the subclavian artery with thoracic aorta and bony invasion. Following carotid-subclavian bypass with Dacron, en bloc resection of the affected lung, ribs, and vertebral bodies was performed. The aorta was prophylactically reinforced with a Gore TAG thoracic endograft prior to adjuvant chemoradiation. The patient remains disease-free at more than 5 years follow-up after completing her treatment course. Endovascular stenting with subsequent chemoradiation may prove to be a viable alternative to palliation or open operative management and prevention of aortic injury during tumor resection and/or adjuvant therapy in select patients with aortic involvement. PMID:26306134

  4. Simplifying Laparoscopic Nephrectomy: The Inferior Approach with En Bloc Stapling of the Renal Hilum

    PubMed Central

    Nadu, Andrei; Lindner, Uri; Ramon, Jacob

    2014-01-01

    Introduction: Laparoscopic nephrectomy (LN) is likely the most common laparoscopic procedure performed by general urologists without formal laparoscopic training. The traditional technique is cumbersome because it entails making an early approach to the hilum with the risk of bleeding and need for conversion. We perform a different technique that we believe is simpler to learn and to teach. It consists of a complete dissection of the inferior and posterior aspects of the kidney, followed by en bloc stapling of the renal hilum. The present report is a detailed description of our technique including outcomes and complications. Materials and Methods: Perioperative data of 129 consecutive patients who underwent LN between November 2003 and September 2007 were prospectively collected and retrospectively reviewed. Complications were reported using the Clavien classification system, and follow-up was performed according to our institution's protocol and included physical examination, blood count, blood chemistry, and renal function tests at every visit, in addition to abdominal computed tomography scan six months after surgery. Additional imaging was scheduled according to disease stage and grade. Results: Mean patient age, tumor size, and operative time were 63 ± 15.6 years, 6.3 ± 2.4 cm, and 128 ± 41.4 minutes, respectively. Median estimated blood loss was 0 mL (0.200). Conversion to open surgery occurred in 3.1% of patients, and 8% of the patients had a blood transfusion. Complications were recorded in 26% of the patients; 91% of them had Clavien grade scores of 1 or 2. Conclusion: We present a standardized technique for LN. Its main advantage is that postpones any manipulation of the hilum to a later step during the procedure when it is easy to identify and control. This decreases early bleeding and main vascular complications. PMID:25392654

  5. Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.

    PubMed

    Rachel, Rivka A; Nagashima, Kunio; O'Sullivan, T Norene; Frost, Laura S; Stefano, Frank P; Marigo, Valeria; Boesze-Battaglia, Kathleen

    2012-01-01

    Humans with Hermansky-Pudlak Syndrome (HPS) or ocular albinism (OA1) display abnormal aspects of organelle biogenesis. The multigenic disorder HPS displays broad defects in biogenesis of lysosome-related organelles including melanosomes, platelet dense granules, and lysosomes. A phenotype of ocular pigmentation in OA1 is a smaller number of macromelanosomes, in contrast to HPS, where in many cases the melanosomes are smaller than normal. In these studies we define the role of the Mreg(dsu) gene, which suppresses the coat color dilution of Myo5a, melanophilin, and Rab27a mutant mice in maintaining melanosome size and distribution. We show that the product of the Mreg(dsu) locus, melanoregulin (MREG), interacts both with members of the HPS BLOC-2 complex and with Oa1 in regulating melanosome size. Loss of MREG function facilitates increase in the size of micromelanosomes in the choroid of the HPS BLOC-2 mutants ruby, ruby2, and cocoa, while a transgenic mouse overexpressing melanoregulin corrects the size of retinal pigment epithelium (RPE) macromelanosomes in Oa1(ko/ko) mice. Collectively, these results suggest that MREG levels regulate pigment incorporation into melanosomes. Immunohistochemical analysis localizes melanoregulin not to melanosomes, but to small vesicles in the cytoplasm of the RPE, consistent with a role for this protein in regulating membrane interactions during melanosome biogenesis. These results provide the first link between the BLOC pathway and Oa1 in melanosome biogenesis, thus supporting the hypothesis that intracellular G-protein coupled receptors may be involved in the biogenesis of other organelles. Furthermore these studies provide the foundation for therapeutic approaches to correct the pigment defects in the RPE of HPS and OA1.

  6. Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.

    PubMed

    Rachel, Rivka A; Nagashima, Kunio; O'Sullivan, T Norene; Frost, Laura S; Stefano, Frank P; Marigo, Valeria; Boesze-Battaglia, Kathleen

    2012-01-01

    Humans with Hermansky-Pudlak Syndrome (HPS) or ocular albinism (OA1) display abnormal aspects of organelle biogenesis. The multigenic disorder HPS displays broad defects in biogenesis of lysosome-related organelles including melanosomes, platelet dense granules, and lysosomes. A phenotype of ocular pigmentation in OA1 is a smaller number of macromelanosomes, in contrast to HPS, where in many cases the melanosomes are smaller than normal. In these studies we define the role of the Mreg(dsu) gene, which suppresses the coat color dilution of Myo5a, melanophilin, and Rab27a mutant mice in maintaining melanosome size and distribution. We show that the product of the Mreg(dsu) locus, melanoregulin (MREG), interacts both with members of the HPS BLOC-2 complex and with Oa1 in regulating melanosome size. Loss of MREG function facilitates increase in the size of micromelanosomes in the choroid of the HPS BLOC-2 mutants ruby, ruby2, and cocoa, while a transgenic mouse overexpressing melanoregulin corrects the size of retinal pigment epithelium (RPE) macromelanosomes in Oa1(ko/ko) mice. Collectively, these results suggest that MREG levels regulate pigment incorporation into melanosomes. Immunohistochemical analysis localizes melanoregulin not to melanosomes, but to small vesicles in the cytoplasm of the RPE, consistent with a role for this protein in regulating membrane interactions during melanosome biogenesis. These results provide the first link between the BLOC pathway and Oa1 in melanosome biogenesis, thus supporting the hypothesis that intracellular G-protein coupled receptors may be involved in the biogenesis of other organelles. Furthermore these studies provide the foundation for therapeutic approaches to correct the pigment defects in the RPE of HPS and OA1. PMID:22984402

  7. Transurethral En Bloc Resection of Bladder Tumor Using an Endoscopic Submucosal Dissection Technique: Preliminary Results in an Animal Model

    PubMed Central

    Morizane, Shuichi; Sejima, Takehiro; Iwamoto, Hideto; Masago, Toshihiko; Honda, Masashi; Ikebuchi, Yuichiro; Matsumoto, Kazuya; Ueki, Masaru; Takenaka, Atsushi

    2016-01-01

    Background Transurethral resection of bladder tumor (TURBT) technique has been considered the routine method for removing most bladder tumors for decades. In contrast, endoscopic submucosal dissection (ESD) is the gold-standard treatment for gastrointestinal superficial tumors. We investigated the effectiveness and applicability of a new technique for en bloc bladder tumor resection using ESD procedure. Methods Four Landrace Large White Duroc female pigs were anesthetized with isoflurane prior endoscopic resection using a large-caliber prototype fiber bronchoscope. After local infiltration of the submucosa with sodium hyaluronate using an injector needle, a section of the target area (1.0–2.0 cm diameter circular area) was cut with the Dual Knife. Results In total, seven target sections were resected from the pigs. The median size of the resected sections was 1.8 cm (range 1.0–2.5 cm) and the median time taken to perform the resection of one section was 20 min (range 4–35 min). These target sections were completely resected en bloc. Although the small bladder perforations occurred on two occasions, no other short-term complications such as uncontrollable bleeding were observed. Conclusion This procedure is a slightly difficult in the pigs with thin bladder walls. However, this procedure with the slim flexible cystoscope may allow us to be able to remove bladder tumors using only light sedation, especially for cases when small tumor recurrence is observed during routine cystoscopy for the patients with non-muscle invasive bladder cancer. PMID:27493485

  8. Results after En Bloc Lateral Wall Decompression Surgery with Orbital Fat Resection in 111 Patients with Graves' Orbitopathy

    PubMed Central

    Fichter, Nicole; Guthoff, Rudolf F.

    2015-01-01

    Purpose. To evaluate the effect of en bloc lateral wall decompression with additional orbital fat resection in terms of exophthalmos reduction and complications. Methods. A retrospective, noncomparative case series study from 1999 to 2011 (chart review) in Graves' orbitopathy (GO) patients. The standardized surgical technique involved removal of the lateral orbital wall including the orbital rim via a lid crease approach combined with additional orbital fat resection. Exophthalmos, diplopia, retrobulbar pressure sensation, and complications were analyzed pre- and postoperatively. Results. A total of 111 patients (164 orbits) with follow-up >3 months were analysed. Mean exophthalmos reduction was 3.05mm and preoperative orbital pressure sensation resolved or improved in all patients. Visual acuity improved significantly in patients undergoing surgery for rehabilitative or vision threatening purposes. Preoperative diplopia improved in 10 patients (9.0%) but worsened in 5 patients (4.5%), necessitating surgical correction in 3 patients. There were no significant complications; however, one patient had slight hollowing of the temporalis muscle around the scar that did not necessitate revision, and another patient with a circumscribed retraction of the scar itself underwent surgical correction. Conclusions. The study confirms the efficiency of en bloc lateral wall decompression in GO in a large series of patients, highlighting the low risk of disturbance of binocular functions and of cosmetic blemish in the temporal midface region. PMID:26221142

  9. Modified kraske procedure with mid-sacrectomy and coccygectomy for en bloc excision of sacral giant cell tumors.

    PubMed

    Gonçalves, Vítor M; Lima, Alvaro; Gíria, João; Carvalho, Nuno; Parreira, José; Cunha E Sá, Manuel

    2014-01-01

    Sacral giant cell tumors are rare neoplasms, histologically benign but potentially very aggressive due to the difficulty in achieving a complete resection, their high recurrence rate, and metastization capability. Although many treatment options have been proposed, en bloc excision with tumor-free margins seems to be the most effective, being associated with long term tumor control, improved outcome, and potential cure. An exemplifying case of a 29-year-old female with progressive complaints of pain and paresthesias in the sacral and perianal regions, constipation, and weight loss for 6 months is presented. The surgical technique for en bloc excision of a large sacral giant cell tumor through a modified Kraske procedure with mid-sacrectomy and coccygectomy is described. Complete resection with wide tumor-free margins was achieved. At 5 years of follow-up the patient is neurologically intact, without evidence of local recurrence on imaging studies. A multidisciplinary surgical procedure is mandatory to completely remove sacral tumors. In the particular case of giant cell tumors, it allows minimizing local recurrence preserving neurovascular function, through a single dorsal and definitive approach. PMID:25386379

  10. Distal Pancreatectomy With En Bloc Celiac Axis Resection for Locally Advanced Pancreatic Cancer

    PubMed Central

    Gong, Haibing; Ma, Ruirui; Gong, Jian; Cai, Chengzong; Song, Zhenshun; Xu, Bin

    2016-01-01

    Abstract Although distal pancreatectomy with en bloc celiac resection (DP-CAR) is used to treat locally advanced pancreatic cancer, the advantages and disadvantages of this surgical procedure remain unclear. The purpose of this study was to evaluate its clinical safety and efficacy. Studies regarding DP-CAR were retrieved from the following databases: PubMed, EMBASE, Web of Science, Cochrane Library, and Chinese electronic databases. Articles were selected according to predesigned inclusion criteria, and data were extracted according to predesigned sheets. Clinical, oncologic, and survival outcomes of DP-CAR were systematically reviewed by hazard ratios (HRs) or odds ratio (OR) using fixed- or random-effects models. Eighteen studies were included. DP-CAR had a longer operating time and greater intraoperative blood loss compared to distal pancreatectomy (DP). A high incidence of vascular reconstruction occurred in DP-CAR: 11.53% (95%CI: 6.88–18.68%) for artery and 33.28% (95%CI: 20.45–49.19%) for vein. The pooled R0 resection rate of DP-CAR was 72.79% (95% CI, 46.19–89.29%). Higher mortality and morbidity rates were seen in DP-CAR, but no significant differences were detected compared to DP; the pooled OR was 1.798 for mortality (95% CI, 0.360–8.989) and 2.106 for morbidity (95% CI, 0.828–5.353). The pooled incidence of postoperative pancreatic fistula (POPF) was 31.31% (95%CI, 23.69–40.12%) in DP-CAR, similar to that of DP (OR = 1.07; 95%CI, 0.52–2.20). The pooled HR against DP-CAR was 5.67 (95%CI, 1.48–21.75) for delayed gastric emptying. The pooled rate of reoperation was 9.74% (95%CI, 4.56–19.59%) in DP-CAR. The combined 1-, 2-, and 3-year survival rates in DP-CAR were 65.22% (49.32–78.34%), 30.20% (21.50–40. 60%), and 18.70% (10.89–30.13%), respectively. The estimated means and medians for survival time in DP-CAR patients were 24.12 (95%CI, 18.26–29.98) months and 17.00 (95%CI, 13.52–20.48) months, respectively. There were no

  11. Risk factors for relapse of middle-stage squamous cell carcinoma of the submandibular region and floor of mouth: the importance of en bloc resection.

    PubMed

    Feng, Zhien; Xu, Qiao Shi; Qin, Li Zheng; Li, Hua; Li, Jin Zhong; Su, Ming; Han, Zhengxue

    2016-01-01

    Our aim was to investigate retrospectively the rate of recurrence in the intervening region for middle-stage squamous cell carcinoma (SCC) of the tongue and identify the factors that predict relapse and prognosis. A total of 204 patients were included, 96 in the en bloc group and 108 in the control group. The groups were comparable. Two patients in the en bloc group (2%) and 12 in the control group (11%) developed recurrences in the intervening region. Kaplan-Meier analysis showed a reduction in the 5-year disease-specific survival once a recurrence had developed after the primary operation (77% compared with 14%, p<0.001). The en bloc group developed significantly fewer recurrences (2%) than the control group (11%) during the five years; p=0.037), and also had better 5-year disease-specific survival (80% compared with 66%, p=0.04). Cox's multivariate regression indicated that the pathological nodal status (p=0.016) and surgical technique (p=0.037) were independent predictive factors for the 5-year recurrence rate, as well as of 5-year disease-specific survival (p=0.001 and p=0.050, respectively). Recurrence in the intervening region is a negative prognostic factor for these patients, and we recommend en bloc resection as the management of choice for middle-stage SCC of the tongue.

  12. Teacher Resource Book for Population Pressure in Indonesia, Problems of Industrialization in Eurasia, Power Blocs in Eurasia. Man on the Earth Series.

    ERIC Educational Resources Information Center

    Gunn, Angus

    This teacher's resource book is a guide to three intermediate texts about Eurasia entitled Population Pressure in Indonesia, Problems of Industrialization in Eurasia, and Power Blocs in Eurasia. The texts are part of the series, Man on the Earth, which probes broad-based issues confronting mankind. The resource book distinguishes 18 major concepts…

  13. En bloc resection of a thoracic chordoma is possible using minimally invasive anterior access: An 8-year follow-up

    PubMed Central

    Goomany, Anand; Timothy, Jake; Robson, Craig; Rao, Abhay

    2016-01-01

    Thoracic spine chordomas are a rare clinical entity and present several diagnostic and management challenges. Posterior debulking techniques are the traditional approach for the resection of thoracic tumors involving the vertebral body. Anterior approaches to the thoracic spine enable complete tumor resection and interbody fusion. However, this approach has previously required a thoracotomy incision, which is associated with significant perioperative morbidity, pain, and the potential for compromised ventilation and subsequent respiratory sequelae. The extreme lateral approach to the anterior spine has been used to treat degenerative disorders of the lower thoracic and lumbar spine, and reduces the potential complications compared with the anterior transperitoneal/transpleural approach. However, such an approach has not been utilized in the treatment of thoracic chordomas. We describe the first case of an en bloc resection of a thoracic chordoma via a minimally invasive eXtreme lateral interbody fusion approach. PMID:26933363

  14. En bloc resection of a thoracic chordoma is possible using minimally invasive anterior access: An 8-year follow-up.

    PubMed

    Goomany, Anand; Timothy, Jake; Robson, Craig; Rao, Abhay

    2016-01-01

    Thoracic spine chordomas are a rare clinical entity and present several diagnostic and management challenges. Posterior debulking techniques are the traditional approach for the resection of thoracic tumors involving the vertebral body. Anterior approaches to the thoracic spine enable complete tumor resection and interbody fusion. However, this approach has previously required a thoracotomy incision, which is associated with significant perioperative morbidity, pain, and the potential for compromised ventilation and subsequent respiratory sequelae. The extreme lateral approach to the anterior spine has been used to treat degenerative disorders of the lower thoracic and lumbar spine, and reduces the potential complications compared with the anterior transperitoneal/transpleural approach. However, such an approach has not been utilized in the treatment of thoracic chordomas. We describe the first case of an en bloc resection of a thoracic chordoma via a minimally invasive eXtreme lateral interbody fusion approach.

  15. Inhomogeneites dans le Vent des Etoiles Wolf-Rayet

    NASA Astrophysics Data System (ADS)

    Robert, Carmelle

    1992-01-01

    autres, une correlation entre le nombre d'inhomogeneites detectees et la vitesse terminale. Cette relation explique bien l'anti-correlation observee entre le niveau de variabilite spectroscopique, photometrique ou polarimetrique et la vitesse terminale. On estime pour toutes les etoiles une masse moyenne des inhomogeneites de 7 times 10^{ -10} Modot et un taux de perte de masse sous la forme d'inhomogeneites detectables qui correspond a 10% de la perte de masse du vent total. L'histogramme du nombre d'inhomogeneites en fonction du leur flux pourrait cependant predire l'existence d'un grand nombre de petites structures non-detectees ici a cause du rapport signal sur bruit relativement trop faible. Ce resultat interessant, qui demande cependant a etre verifie, suggere que le vent pourrait etre forme d'un ensemble quasi infini d'inhomogeneites. En ajustant une loi de puissance dans l'histogramme du flux de chaque etoile, on calcule, pour les plus grosses structures, un exposant = -2.4 +/- 0.2. On constate alors que cette valeur est compatible avec celle que predit la turbulence supersonique. Les structures observees dans les spectres des etoiles WR ont des caracteristiques tres semblables a celles des etoiles O. On propose alors que les perturbations observees chez ces 2 types d'etoiles ont une meme origine. Parmi les mecanismes deja proposes dans le passe pour expliquer les variations des etoiles O et WR (instabilites radiatives, pulsations et champ magnetique) on ne saurait encore dire <=uel, ou lesquels, correspondent le mieux aux observations. Dans les projets futurs, on propose de considerer aussi le role que pourrait avoir la turbulence pour expliquer les perturbations du vent stellaire.

  16. [Curative Left Pulmonary Resection Combined with Total En Bloc Spondylectomy for Lung Cancer Invading the Second and Third Thoracic Vertebral Bodies].

    PubMed

    Endoh, Makoto; Oizumi, Hiroyuki; Kato, Hirohisa; Suzuki, Jun; Watarai, Hikaru; Hamada, Akira; Suzuki, Katsuyuki; Nakahashi, Kenta; Funata, Toshiko; Takahashi, Ai; Sadahiro, Mitsuaki

    2016-09-01

    Introduction of spinal surgery into the operation of lung cancer has made extensive surgical treatment feasible with acceptable long-term survival. We report our experience on total en bloc total spondylectomy for lung cancer invading the spine. A 60-year-old man was diagnosed with lung adenocarcinoma of the apicodorsal segment of the left lobe with invasion of the 2nd and 3rd thoracic vertebral bodies. After induction chemoradiotherapy, we performed en bloc resection through a posterolateral thoracotomy in the right decubitus position and a posterior median approach in the prone position. The thoracic manipulation was done earlier, making it useful for the dissection of the prevertebral plane from the posterior mediastinum at the upper thoracic level in addition to confirmation of non-N2 disease. Vertebral stabilization was achieved with rod fixation and placement of a titanium mesh cage between the remaining vertebral bodies. PMID:27586310

  17. MeCP2 Regulates the Synaptic Expression of a Dysbindin-BLOC-1 Network Component in Mouse Brain and Human Induced Pluripotent Stem Cell-Derived Neurons

    PubMed Central

    Larimore, Jennifer; Ryder, Pearl V.; Kim, Kun-Yong; Ambrose, L. Alex; Chapleau, Christopher; Calfa, Gaston; Gross, Christina; Bassell, Gary J.; Pozzo-Miller, Lucas; Smith, Yoland; Talbot, Konrad; Park, In-Hyun; Faundez, Victor

    2013-01-01

    Clinical, epidemiological, and genetic evidence suggest overlapping pathogenic mechanisms between autism spectrum disorder (ASD) and schizophrenia. We tested this hypothesis by asking if mutations in the ASD gene MECP2 which cause Rett syndrome affect the expression of genes encoding the schizophrenia risk factor dysbindin, a subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), and associated interacting proteins. We measured mRNA and protein levels of key components of a dysbindin interaction network by, quantitative real time PCR and quantitative immunohistochemistry in hippocampal samples of wild-type and Mecp2 mutant mice. In addition, we confirmed results by performing immunohistochemistry of normal human hippocampus and quantitative qRT-PCR of human inducible pluripotent stem cells (iPSCs)-derived human neurons from Rett syndrome patients. We defined the distribution of the BLOC-1 subunit pallidin in human and mouse hippocampus and contrasted this distribution with that of symptomatic Mecp2 mutant mice. Neurons from mutant mice and Rett syndrome patients displayed selectively reduced levels of pallidin transcript. Pallidin immunoreactivity decreased in the hippocampus of symptomatic Mecp2 mutant mice, a feature most prominent at asymmetric synapses as determined by immunoelectron microcopy. Pallidin immunoreactivity decreased concomitantly with reduced BDNF content in the hippocampus of Mecp2 mice. Similarly, BDNF content was reduced in the hippocampus of BLOC-1 deficient mice suggesting that genetic defects in BLOC-1 are upstream of the BDNF phenotype in Mecp2 deficient mice. Our results demonstrate that the ASD-related gene Mecp2 regulates the expression of components belonging to the dysbindin interactome and these molecular differences may contribute to synaptic phenotypes that characterize Mecp2 deficiencies and ASD. PMID:23750231

  18. Evacuation of the Pleural Cavity With an Infant Feeding Catheter Following en Bloc Resection of Hepatocellular Carcinoma and Involved Diaphragm–an Institutional Experience

    PubMed Central

    Chung, C. C.; Leow, C. K.; Leung, K. L.; Lai, P. B. S.

    1998-01-01

    En bloc resection of hepatocellular carcinoma and the involved diaphragm will, towards the end of operation, require evacuation of the pleural cavity, usually with a chest drain. We describe our method and experience of evacuating the pleural cavity, at the time of diaphragmatic repair, with an infant feeding catheter without the need of a chest drain. We have found the method safe and efficacious. PMID:9893236

  19. Quantification of the Young's modulus of the primary plant cell wall using Bending-Lab-On-Chip (BLOC).

    PubMed

    Nezhad, Amir Sanati; Naghavi, Mahsa; Packirisamy, Muthukumaran; Bhat, Rama; Geitmann, Anja

    2013-07-01

    Biomechanical and mathematical modeling of plant developmental processes requires quantitative information about the structural and mechanical properties of living cells, tissues and cellular components. A crucial mechanical property of plant cells is the mechanical stiffness or Young's modulus of its cell wall. Measuring this property in situ at single cell wall level is technically challenging. Here, a bending test is implemented in a chip, called Bending-Lab-On-a-Chip (BLOC), to quantify this biomechanical property for a widely investigated cellular model system, the pollen tube. Pollen along with culture medium is introduced into a microfluidic chip and the growing pollen tube is exposed to a bending force created through fluid loading. The flexural rigidity of the pollen tube and the Young's modulus of the cell wall are estimated through finite element modeling of the observed fluid-structure interaction. An average value of 350 MPa was experimentally estimated for the Young's modulus in longitudinal direction of the cell wall of Camellia pollen tubes. This value is in agreement with the result of an independent method based on cellular shrinkage after plasmolysis and with the mechanical properties of in vitro reconstituted cellulose-callose material. PMID:23571308

  20. [Validation of semantic and pragmatic modules of the Criterial and Objective Language Battery (BLOC) in Chilean children].

    PubMed

    Castillo Guevara, Ramón D; Puyuelo Sanclemente, Miguel; Chaigneau Orfanoz, Sergio E; Martínez Jiménez, Luis

    2006-05-01

    The aim of this work was to analyse the psychometric properties of the semantics and pragmatics modules of the Objective and Criterial Language Battery (BLOC). For the semantics module (n= 259), Cronbach's alpha was 0.84; for the pragmatics module (n= 142), Cronbach's alpha was 0.91. A Categoric Principal Components Analysis (CAPCAT), produced unidimentional solutions, explaining 41.65% of the variance in the semantics module, and 41.77% in the pragmatics module. We did not find differences in performance by sex. By socio-economic status, lower status children performed worse than those of middle and higher status, but only in the semantics module. Differences by age were small, with both modules producing between 3 and 4 homogeneous groups with substantial overlap. Lack of discrimination is probably related to reduced variability due to low performance in the Chilean samples. Compared to Spain, medians in the semantics module were lower than expected (though medians in the pragmatics module were slightly higher).

  1. Double concentric craniotomy: Safe and effective technique to achieve an en bloc resection of tumor involving both skull and duraa

    PubMed Central

    Fornaro, R.; Altieri, R.; Garbossa, D.; Zenga, F.; Tartara, F.; Ducati, A

    2015-01-01

    Introduction Many tumors can involve the skull. Meningiomas are one of the most common intracranial neoplasms and invasion of the bone was described in 49% of cases. Other neoplastic lesions that can arise in bone, or involve it, are metastases, hemangiomas, aggressive cutis carcinomas and sarcomas. Radical excision is the golden standard of treatment but elevating a bone flap when the tumor involves both the skull and the dura could represent a technical challenge. Presentation of case We report the technical details of our approach to remove a meningioma involving both skull and dura in a man aged 45. Patient underwent gross total excision and cranioplasty with PEEK custom made prothesis (Synthes™). Discussion We describe a double concentric craniotomy (DCC) technique where the tumor involving the bone is before left in situ, exposing normal dura, to perform afterwards en-bloc excision with minimal traction of brain surface. Conclusion DCC is a safe and effective technique to remove tumor involving both skull and dural structures under direct vision. PMID:26057993

  2. An en bloc avulsion fracture of tibial tuberosity and Gerdy's tubercle in an adolescent basketball player: a case report.

    PubMed

    Yoo, Jae Ho; Hahn, Sung Ho; Yang, Bo Kyu; Yi, Seung Rim; Ahn, Young Joon; Yoon, Dong Jin; Kim, Jin Hong

    2007-06-01

    We report a case of en bloc avulsion fracture of tibial tuberosity and Gerdy's tubercle, which has never been reported. A 14-year-old boy suffered from an acute pain in his left knee during running just before a jump. Simple radiographs showed an avulsion of the tibial tuberosity. On CT scans, the fractured fragment was attached not only to patellar tendon but also to iliotibial band (ITB) via Gerdy's tubercle. MRI evaluation revealed no intra-articular associated pathology. Open reduction and internal fixation with three cannulated screws were performed under lateral parapatellar approach to expose both the tibial tuberosity with patellar tendon and Gerdy's tubercle with ITB. At postoperative 1 year, he could walk, run, squat, and complained of no difficulty in activities on daily living with full range-of-motion of the knee. Radiographs showed well-healed fracture in situ. Gradually, he returned to sports activity. We believe that the injury was caused by the dynamic pull of quadriceps muscle via patellar tendon onto tibial tuberosity and the mostly static pull of ITB onto Gerdy's tubercle, both of which took a part in the fracture of the anterolateral portion of the unfused epiphysis of proximal tibia. The pes anserinus attaching on the anteromedial metaphysis of proximal tibia might exert the opposing deforming force. Preoperative planning including the determination of the extent of fracture and recognition of concomitant injury is a prerequisite for appropriate treatment.

  3. Le Figaro. Revised.

    ERIC Educational Resources Information Center

    Crawford, Linda

    These instructional materials are designed for students with some French reading skills and vocabulary in late beginning or early intermediate senior high school French. The objectives are to introduce students to a French newspaper, "Le Figaro," and develop reading skills for skimming, gathering specific information, and relying on cognates. The…

  4. Le syndrome du canal d’Alcock ou névralgie pudendale : un diagnostic à ne pas méconnaître

    PubMed Central

    Ziouziou, Imad; Bennani, Hassan; Zizi, Mohamed; Karmouni, Tarik; Khader, Khalid El; Koutani, Abdellatif; Andaloussi, Ahmed Iben Attya

    2013-01-01

    Résumé Le syndrome du canal d’Alcock – ou névralgie pudendale – est lié à la compression chronique du nerf pudendal dans la fossette ischiorectale ou au niveau du ligament sacroépineux. Le diagnostic du syndrome d’Alcock est surtout clinique. Les examens complémentaires sont dominés par les explorations électrophysiologiques et le test de bloc anesthésique. Le diagnostic repose sur des critères bien précis, soit les critères de Nantes. La prise en charge doit être globale, comprenant un traitement médicamenteux, des infiltrations, des techniques de neuromodulation, et dans les cas graves ou résistants, un traitement chirurgical qui consiste à libérer le nerf pudendal. Les névralgies pudendales peuvent être rencontrées après traitement d’une incontinence urinaire d’effort par bande-lettes sous-urétrales (TVT). Ce syndrome motive des consultations en urologie, car la douleur intéresse le territoire du périnée et des organes génitaux. Des signes urinaires peuvent aussi accompagner cette douleur. Il est donc judicieux de connaître cette pathologie. PMID:23914265

  5. Le mouvement du pôle

    NASA Astrophysics Data System (ADS)

    Bizouard, Christian

    2012-03-01

    Les variations de la rotation terrestre. En conditionnant à la fois notre vie quotidienne, notre perception du ciel, et bon nombre de phénomènes géophysiques comme la formation des cyclones, la rotation de la Terre se trouve au croisement de plusieurs disciplines. Si le phenomena se faisait uniformément, le sujet serait vite discuté, mais c'est parce que la rotation terrestre varie, même imperceptiblement pour nos sens, dans sa vitesse angulaire comme dans la direction de son axe, qu'elle suscite un grand intérêt. D'abord pour des raisons pratiques : non seulement les aléas de la rotation terrestre modi_ent à la longue les pointés astrométriques à un instant donné de la journée mais in_uencent aussi les mesures opérées par les techniques spatiales ; en consequence l'exploitation de ces mesures, par exemple pour déterminer les orbites des satellites impliqués ou pratiquer le positionnement au sol, nécessite une connaissance précise de ces variations. Plus fondamentalement, elles traduisent les propriétés globales de la Terre comme les processus physiques qui s'y déroulent, si bien qu'en analysant les causes des fluctuations observées, on dispose d'un moyen de mieux connaître notre globe. La découverte progressive des fluctuations de la rotation de la Terre a une longue histoire. Sous l'angle des techniques d'observation, trois époques se pro-celle du pointé astrométrique à l'oeil nu, à l'aide d'instruments en bois ou métalliques (quart de cercle muraux par exemple). À partir du XVIIe siècle débute l'astrométrie télescopique dont les pointés sont complétés par des datations de plus en plus précises grâce à l'invention d'horloges régulées par balancier. Cette deuxième époque se termine vers 1960, avec l'avènement des techniques spatiales : les pointés astrométriques sont délaissés au profit de la mesure ultra-précise de durées ou de fréquences de signaux électromagnétiques, grâce à l'invention des horloges

  6. Locally aggressive aneurysmal bone cyst of C4 vertebra treated by total en bloc excision and anterior plus posterior cervical instrumentation

    PubMed Central

    Parmar, Himanshu N.; Agrawal, Vinod A.; Shah, Munjal S.; Nanda, Saurav N.

    2015-01-01

    We are presenting a case of cervical (C4) aneurysmal bone cyst in a 13-year-old girl, came to the outpatient department with neck pain and stiffness since 6 months and normal neurology. We did an en bloc excision of locally aggressive tumor through anterior plus posterior approach and stabilization by lateral mass screw fixation and anterior cervical instrumentation. Involvement of several adjacent cervical vertebrae by an aneurysmal bone cyst is rare, and conventional treatment with curettage and bone grafting is most likely to carry a high rate of recurrence and spinal instability. We recommend complete excision of the tumor and instrumentation in a single stage to avoid instability. PMID:26288549

  7. Image-guided multilevel vertebral osteotomies for en bloc resection of giant cell tumor of the thoracic spine: case report and description of operative technique

    PubMed Central

    Smitherman, Sheila M.; Tatsui, Claudio E.; Rao, Ganesh; Walsh, Garrett

    2010-01-01

    The use of frameless stereotactic navigation is gaining popularity in spinal surgery. Although initially used in the spine for placement of lumbar pedicle screws, this technology has expanded to facilitate placement of spinal instrumentation at virtually all spinal levels. While previous reports have described the utility of image guidance for placement of spinal instrumentation, its use in assisting with resection of complex spine tumors has not been extensively reported. Here we describe the use of frameless stereotaxy to guide a complex, four-level sagittal vertebral osteotomy for en bloc resection of a giant cell tumor involving the chest wall and thoracic spine. PMID:20069317

  8. Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress

    PubMed Central

    Itzhak, Daniel N.; Wardell, Christopher P.; Morgan, Gareth J.; Davies, Faith E.

    2015-01-01

    The unfolded protein response (UPR) remediates endoplasmic reticulum (ER) stress. IRE1, a component of the UPR, senses misfolded protein and cleaves XBP1 mRNA, which is ligated to code for the prosurvival transcription factor. IRE1 also cleaves other mRNAs preceding their degradation, termed regulated IRE1-dependent mRNA decay (RIDD). It has been reported that RIDD may be involved in cell viability under stress and therefore may contribute to cancer cell viability. To investigate RIDD targets that may have functional relevance in cell survival, we identified conserved RIDD targets containing stringent IRE1 RNase target sequences. Using a systematic bioinformatics approach with quantitative-PCR (qPCR) validation, we show that only BLOC1S1 is consistently a RIDD target in all systems tested. Using cancer cell lines, we show that BLOC1S1 is specifically cleaved by IRE1 at guanine 444, but only under conditions of IRE1 hyperactivation. BLOC1S1 cleavage is temporally separate from XBP1 splicing, occurring after depletion of unspliced XBP1. Expression of an uncleavable BLOC1S1 mutant or inhibition of RIDD using an IRE1 RNase inhibitor did not affect cellular recovery from acute ER stress. These data demonstrate that although hyperactivated IRE1 specifically cleaves BLOC1S1, this cleavage event and RIDD as a whole are dispensable for cell viability under acute stress. PMID:25870107

  9. Single vs dual (en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience

    PubMed Central

    Al-Shraideh, Yousef; Farooq, Umar; El-Hennawy, Hany; Farney, Alan C; Palanisamy, Amudha; Rogers, Jeffrey; Orlando, Giuseppe; Khan, Muhammad; Reeves-Daniel, Amber; Doares, William; Kaczmorski, Scott; Gautreaux, Michael D; Iskandar, Samy S; Hairston, Gloria; Brim, Elizabeth; Mangus, Margaret; Stratta, Robert J

    2016-01-01

    AIM: To compare outcomes between single and dual en bloc (EB) kidney transplants (KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached to the inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients. RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors (17 mo vs 38 mo, P < 0.001), mean weight (11.0 kg vs 17.4 kg, P = 0.046) and male donors (50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time (21 h), kidney donor profile index (KDPI; 73% vs 62%) and levels of serum creatinine (SCr, 0.37 mg/dL vs 0.49 mg/dL, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence (12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay (mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection (6% vs 16%), operative complications (3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively (all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/dL vs 1.35 mg/dL and 72.5 mL/min per 1.73 m2 vs 60.5 mL/min per 1.73 m2 (both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can

  10. Pleural omentalisation with en bloc ligation of the thoracic duct and pericardiectomy for idiopathic chylothorax in nine dogs and four cats.

    PubMed

    Bussadori, Roberto; Provera, Alessandra; Martano, Marina; Morello, Emanuela; Gonzalo-Orden, Josè Manuel; La Rosa, Giuseppe; Stefano, Nicoli; Maria, Repetto Silvia; Sara, Zabarino; Buracco, Paolo

    2011-05-01

    Conventional treatment of idiopathic chylothorax (IC) involves thoracic duct (TD) ligation (with/without lymphagiography) combined with subphrenic pericardiectomy. Nine dogs and four cats with IC, which received intrathoracic omentalisation with TD en bloc ligation (not preceded by lymphangiography) and subphrenic pericardiectomy, were evaluated retrospectively. Seven of nine dogs and 3/4 cats were still alive and disease-free at the time of reporting (range 10-53 and 19-31 months, respectively). Clinical signs of IC did not decrease after the first surgery in one cat and one dog; in another dog clinical signs recurred after 5 months. Overall efficacy rate of this one-stage combined procedure was 77% (6 months), 73% (12 months), and 57% (24 months). Where a second surgery was performed in case of failure, the success rate in dogs was 89% (6 months) and 80% (24 months). Addition of pleural omentalisation to TD en bloc ligation and subphrenic pericardiectomy does not seem to improve results when compared with published data and at present does not seem advisable as a first choice.

  11. Bloc tectonic rotations recorded in the Neogene and Quaternary magmatic rocks from Northwestern Algeria: preliminary paleomagnetic results.

    NASA Astrophysics Data System (ADS)

    El Messaoud Derder, Mohamed; Robion, Philippe; Maouche, Said; Bayou, Boualem; Amenna, Mohamed; Henry, Bernard; Missenard, Yves; Ouabadi, Aziouz; Bestandji, Rafik; Ayache, Mohamed

    2016-04-01

    area. M.E.M. DERDER, B. HENRY, H. DJELLIT, C. DORBATH, H. YMEL, S. GHARBI, M. GUEMACHE AND A. ABTOUT : Bloc rotation tectonics in northern Algeria revealed by paleomagnetic investigations in the "Mitidja" basin (Algiers area, Algeria), "International Earthquake Symposium Kocaeli 2009". 17-19 August 2009 M.E.M., DERDER, B. HENRY, M. AMENNA, B. BAYOU, S. MAOUCHE, J. BESSE, A. ABTOUT, H. BOUKERBOUT, M. BESSEDIK, S. BOUROUIS AND M. AYACHE : "Tectonic Evolution of the Active "Chelif" Basin (Northern Algeria) from Paleomagnetic and Magnetic Fabric Investigations", in " New Frontiers in Tectonic Research at the Midst of Plate Convergence "Intech Publisher" book, pp: 3-26, Intech Publisher, ISBN 978-953-307-594-5, 2011. M.E.M. DERDER, B. HENRY, S. MAOUCHE, B. BAYOU ,M. AMENNA, J. BESSE, M. BESSEDIK, D. BELHAI AND M. AYACHE: Transpressive tectonics along a major E-W crustal structure on the Algerian continental margin: blocks rotations revealed by a paleomagnetic analysis. Tectonophysics, 593 (2013) 183-192

  12. Distal Pancreatectomy With En Bloc Celiac Axis Resection for Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis.

    PubMed

    Gong, Haibing; Ma, Ruirui; Gong, Jian; Cai, Chengzong; Song, Zhenshun; Xu, Bin

    2016-03-01

    Although distal pancreatectomy with en bloc celiac resection (DP-CAR) is used to treat locally advanced pancreatic cancer, the advantages and disadvantages of this surgical procedure remain unclear. The purpose of this study was to evaluate its clinical safety and efficacy.Studies regarding DP-CAR were retrieved from the following databases: PubMed, EMBASE, Web of Science, Cochrane Library, and Chinese electronic databases. Articles were selected according to predesigned inclusion criteria, and data were extracted according to predesigned sheets. Clinical, oncologic, and survival outcomes of DP-CAR were systematically reviewed by hazard ratios (HRs) or odds ratio (OR) using fixed- or random-effects models.Eighteen studies were included. DP-CAR had a longer operating time and greater intraoperative blood loss compared to distal pancreatectomy (DP). A high incidence of vascular reconstruction occurred in DP-CAR: 11.53% (95%CI: 6.88-18.68%) for artery and 33.28% (95%CI: 20.45-49.19%) for vein. The pooled R0 resection rate of DP-CAR was 72.79% (95% CI, 46.19-89.29%). Higher mortality and morbidity rates were seen in DP-CAR, but no significant differences were detected compared to DP; the pooled OR was 1.798 for mortality (95% CI, 0.360-8.989) and 2.106 for morbidity (95% CI, 0.828-5.353). The pooled incidence of postoperative pancreatic fistula (POPF) was 31.31% (95%CI, 23.69-40.12%) in DP-CAR, similar to that of DP (OR = 1.07; 95%CI, 0.52-2.20). The pooled HR against DP-CAR was 5.67 (95%CI, 1.48-21.75) for delayed gastric emptying. The pooled rate of reoperation was 9.74% (95%CI, 4.56-19.59%) in DP-CAR. The combined 1-, 2-, and 3-year survival rates in DP-CAR were 65.22% (49.32-78.34%), 30.20% (21.50-40. 60%), and 18.70% (10.89-30.13%), respectively. The estimated means and medians for survival time in DP-CAR patients were 24.12 (95%CI, 18.26-29.98) months and 17.00 (95%CI, 13.52-20.48) months, respectively. There were no significant differences regarding

  13. Mental health of immigrants from the former Soviet Bloc: a future problem for primary health care in the enlarged European Union? A cross-sectional study

    PubMed Central

    Blomstedt, Yulia; Johansson, Sven-Erik; Sundquist, Jan

    2007-01-01

    Background Enlargement of the European Union has caused worries about the possibility of increased migration from its new members, the former Soviet countries, and consequently increased demands on the health care systems of the host countries. This study investigated whether or not earlier immigrants from the former Soviet Bloc have poorer self-reported mental health, measured as self-reported psychiatric illness and psychosomatic complaints, than the host population in Sweden. It also examined the particular factors which might determine the self-reported mental health of these immigrants. Methods The cross-sectional national sample included 25–84-year-old Swedish-born persons (n = 35,459) and immigrants from Poland (n = 161), other East European countries (n = 164), and the former Soviet Union (n = 60) who arrived in Sweden after 1944 and were interviewed during 1994–2001. Unconditional multivariate logistic regression was used in the analyses. Results The findings indicated that the country of birth had a profound influence on self-reported mental health. Polish and other East European immigrants in general had a twofold higher odds ratio of reporting psychiatric illness and psychosomatic complaints, which fact could not be explained by adjustments for the demographic and socioeconomic variables. However, immigrants from the former Soviet Union had odds similar to those of the Swedish-born reference group. Adjustments for migration-related variables (language spoken at home and years in Sweden) changed the association between the country of birth and the outcomes only to a limited extent. Conclusion Since poor mental health may hinder acculturation, the mental health of immigrants from Poland and other East European countries should be acknowledged, particularly with the expansion of the European Union and inclusion of nine former Soviet Bloc countries by 2007. PMID:17328817

  14. Le couplage pulsation-convection.

    NASA Astrophysics Data System (ADS)

    Poyet, J.-P.

    Contents: Quelques problèmes Boussinesq bien definis. Les théories de couplage pulsation radiale-convection. Quelques pas dans le domaine du couplage des pulsations non radiales avec la convection. Conclusion.

  15. Le bégaiement

    PubMed Central

    Perez, Hector R.; Stoeckle, James H.

    2016-01-01

    Résumé Objectif Fournir une mise à jour sur l’épidémiologie, l’hérédité, la physiopathologie, le diagnostic et le traitement du bégaiement développemental. Qualité des données Une recherche d’études récentes ou non portant sur l’épidémiologie, l’hérédité, la physiopathologie, le diagnostic et le traitement du bégaiement développemental a été effectuée dans les bases de données MEDLINE et Cochrane. La plupart des recommandations s’appuient sur des études de petite envergure, des données probantes de qualité limitée ou des consensus. Message principal Le bégaiement est un trouble d’élocution fréquent chez les personnes de tous âges, il altère la fluidité verbale normale et l’enchaînement du discours. Le bégaiement a été lié à des différences de l’anatomie, du fonctionnement et de la régulation dopaminergique du cerveau qui seraient de source génétique. Il importe de poser le diagnostic avec attention et de faire les recommandations qui conviennent chez les enfants, car de plus en plus, le consensus veut que l’intervention précoce par un traitement d’orthophonie soit cruciale chez les enfants bègues. Chez les adultes, le bégaiement est lié à une morbidité psychosociale substantielle, dont l’anxiété sociale et une piètre qualité de vie. Les traitements pharmacologiques ont soulevé l’intérêt depuis quelques années, mais les données cliniques sont limitées. Le traitement des enfants et des adultes repose sur l’orthophonie. Conclusion De plus en plus de recherches ont tenté de lever le voile sur la physiopathologie du bégaiement. La meilleure solution pour les enfants et les adultes bègues demeure la recommandation à un traitement d’orthophonie.

  16. Le pompage optique naturel dans le milieu astrophysique

    NASA Astrophysics Data System (ADS)

    Pecker, J.-C.

    The title of this lecture abstracts only a part of it : the importance in astrophysics of the study of non-LTE situations has become considerable, as well in the stellar atmospheres as, still more, in the study of fortuitous coincidences as a mechanism of formation of emission line nebular spectra, or of molecular interstellar « masers ». Another part of this talk underlines the role of Kastler in his time, and describes his warm personality through his public reactions in front of the nuclear armement, of the Viet-Nam and Algerian wars, of the problems of political refugees... Kastler was a great scientist ; he was also a courageous humanist. 1976 : Les accords nucléaires du Brésil : allocution d'ouverture (19 mars). Colloque sur le sujet ci-dessus. 1976 : La promotion de la culture dans le nouvel ordre économique international, allocution à l'occasion d'une table ronde sur ce thème par l'UNESCO (23-27 juin 1976) ; « Sciences et Techniques », octobre 1976. 1979 : La bête immonde (avec J.-C. Pecker), « Le Matin », 20 mars. 1979 : Appel à nos ministres (avec J.-C. Pecker), « Le Monde », 13 décembre. 1979 : Le flou, le ténébreux, l'irrationnel (avec J.-C. Pecker), « Le Monde », 14 septembre. 1980 : Education à la paix, Préface, in : Publ. UNESCO. 1981 : Le vrai danger, « Le Monde », 6 août 1981. 1982 : Nucléaire civil et militaire, « Le Monde », 1er juin 1982. 1982 : Les scientifiques face à la perspective d'holocauste nucléaire (texte inédit). Le titre de cette communication en résume seulement une partie : l'importance prise en astrophysique par l'analyse des situations hors ETL est devenue considérable, qu'il s'agisse des atmosphères stellaires, ou plus encore, des coïncidences fortuites de la formation des spectres d'émission nébulaires, ou des « masers » moléculaires interstellaires. Une autre partie de cet exposé souligne lele de Kastler dans son époque, et décrit sa personnalité généreuse à travers ses r

  17. L'influence d'un stage d'enseignement dans un musee de sciences naturelles sur le sentiment d'autoefficacite en sciences de futurs enseignants

    NASA Astrophysics Data System (ADS)

    Deblois, Annick

    Cette etude qualitative multicas est ancree dans l'approche sociale-cognitive de la theorie de l'autoefficacite de Bandura (1977). Elle s'interesse a quatre stages a l'enseignement qui se sont deroules au Musee canadien de la nature a Ottawa, Canada, en 2009. L'utilisation de donnees secondaires issues du questionnaire STEBI-B traduit et modifie (Dionne et Couture, 2010) ainsi que des entrevues semi-dirigees ont permis une analyse du changement du sentiment d'autoefficacite en sciences chez les stagiaires. Les elements les plus interessants de cette recherche sont l'apprentissage vicariant et la possibilite de repetition qui favorise une meilleure connaissance de soi et une pratique reflexive. Les resultats, dans l'ensemble positifs, illustrent bien le potentiel d'un tel stage afin de rehausser le sentiment d'autoefficacite en sciences chez des stagiaires en enseignement, particulierement chez ceux qui se destinent a enseigner a l'elementaire puisque ceux-ci ont souvent une formation academique dans un domaine autre que les sciences.

  18. Le LHC, un tunnel cosmique

    SciTech Connect

    2009-09-17

    Et si la lumière au bout du tunnel du LHC était cosmique ? En d’autres termes, qu’est-ce que le LHC peut nous apporter dans la connaissance de l’Univers ? Car la montée en énergie des accélérateurs de particules nous permet de mieux appréhender l’univers primordial, chaud et dense. Mais dans quel sens dit-on que le LHC reproduit des conditions proches du Big bang ? Quelles informations nous apporte-t-il sur le contenu de l’Univers ? La matière noire est-elle détectable au LHC ? L’énergie noire ? Pourquoi l’antimatière accumulée au CERN est-elle si rare dans l’Univers ? Et si le CERN a bâti sa réputation sur l’exploration des forces faibles et fortes qui opèrent au sein des atomes et de leurs noyaux, est-ce que le LHC peut nous apporter des informations sur la force gravitationnelle qui gouverne l’évolution cosmique ? Depuis une trentaine d’années, notre compréhension de l’univers dans ses plus grandes dimensions et l’appréhension de son comportement aux plus petites distances sont intimement liées : en quoi le LHC va-t-il tester expérimentalement cette vision unifiée ? Tout public, entrée libre / Réservations au +41 (0)22 767 76 76

  19. Laparoscopic anterior pelvic exenteration for locoregionally advanced rectal cancer directly invading the urinary bladder: A case report of low anterior resection with en bloc cystectomy for sphincter preservation

    PubMed Central

    Nakashima, Shinya; Hamada, Takeomi; Nishida, Takahiro; Maehara, Naoki; Ikeda, Takuto; Tsukino, Hiromasa; Mukai, Shoichiro; Kamoto, Toshiyuki; Kondo, Kazuhiro

    2015-01-01

    Abstract Laparoscopic multi‐visceral resection in patients with T4 colorectal cancer remains controversial. A 73‐year‐old man was admitted to the hospital for rectosigmoid cancer directly invading the urinary bladder trigone without distant metastasis. We successfully performed complete resection by laparoscopic anterior pelvic exenteration while preserving the anus. After laparoscopic mobilization of the rectum, urinary bladder, and prostate, the urethra and urethral catheter were dissected to reveal the lower rectum. By pulling the urethral catheter toward the head, the prostate was excised retrogradely from the lower rectum anterior wall. The lower rectum was resected and anastomosed by the double stapling technique with a safe distal margin from the tumor. Pathological findings of the resected specimen indicated no residual tumor in the surgical margin. There was no evidence of recurrence 34 months after surgery. En bloc, R0, laparoscopic anterior pelvic exenteration for T4 rectal cancer is feasible. However, further studies with long‐term follow‐up are required to resolve oncological outcomes. PMID:26303734

  20. Laparoscopic anterior pelvic exenteration for locoregionally advanced rectal cancer directly invading the urinary bladder: A case report of low anterior resection with en bloc cystectomy for sphincter preservation.

    PubMed

    Ishizaki, Hidenobu; Nakashima, Shinya; Hamada, Takeomi; Nishida, Takahiro; Maehara, Naoki; Ikeda, Takuto; Tsukino, Hiromasa; Mukai, Shoichiro; Kamoto, Toshiyuki; Kondo, Kazuhiro

    2015-08-01

    Laparoscopic multi-visceral resection in patients with T4 colorectal cancer remains controversial. A 73-year-old man was admitted to the hospital for rectosigmoid cancer directly invading the urinary bladder trigone without distant metastasis. We successfully performed complete resection by laparoscopic anterior pelvic exenteration while preserving the anus. After laparoscopic mobilization of the rectum, urinary bladder, and prostate, the urethra and urethral catheter were dissected to reveal the lower rectum. By pulling the urethral catheter toward the head, the prostate was excised retrogradely from the lower rectum anterior wall. The lower rectum was resected and anastomosed by the double stapling technique with a safe distal margin from the tumor. Pathological findings of the resected specimen indicated no residual tumor in the surgical margin. There was no evidence of recurrence 34 months after surgery. En bloc, R0, laparoscopic anterior pelvic exenteration for T4 rectal cancer is feasible. However, further studies with long-term follow-up are required to resolve oncological outcomes.

  1. [A 5-year survival case of locally advanced cancer of the pancreatic body treated by distal pancreatectomy with en bloc celiac axis resection after neoadjuvant chemoradiation therapy].

    PubMed

    Iseki, Masahiro; Motoi, Fuyuhiko; Mizuma, Masamichi; Hayashi, Hiroki; Nakagawa, Kei; Okada, Takaho; Otsuka, Hideo; Ottomo, Shigeru; Sakata, Naoaki; Fukase, Koji; Yoshida, Hiroshi; Onogawa, Tohru; Naito, Takeshi; Katayose, Yu; Egawa, Shinichi; Unno, Michiaki

    2012-11-01

    A 59-year-old man was diagnosed with locally advanced cancer of the pancreatic body, involving the nerve plexus around the celiac axis, the common hepatic artery, and the splenic artery. He was treated with a combination of irradiation (2 Gy/day, total 24 Gy) and 600 mg/m2 of gemcitabine(GEM)biweekly. The tumor size and the involved plexus area were not diminished, but CA19-9 was reduced by half. Distal pancreatectomy with en bloc celiac axis resection(DP-CAR)was performed. The histological findings indicated extensive invasion into the nerve plexus, including that adjacent to the stump of the pancreas, and thus the R classification was R1. After surgery, 1,000 mg/m2 of GEM was administered biweekly. The chemotherapy has been performed for 5 years to prevent local and systemic recurrence. No recurrence has been found 5 years after surgery. Multidisciplinary treatment, combined with neoadjuvant chemoradiation therapy, curative-intent resection, and postoperative chemotherapy is important for effective treatment of locally advanced pancreatic cancer. PMID:23267939

  2. Vítězslav Orel (1926-2015): Gregor Mendel's biographer and the rehabilitation of genetics in the Communist Bloc.

    PubMed

    Paleček, Pavel

    2016-09-01

    At almost 90 years of age, we have lost the author of the founding historical works on Johann Gregor Mendel. Vítězslav Orel served for almost 30 years as the editor of the journal Folia Mendeliana. His work was beset by the wider problems associated with Mendel's recognition in the Communist Bloc, and by the way in which narratives of the history of science could be co-opted into the service of Cold War and post-Cold War political agendas. Orel played a key role in the organization of the Mendel symposium of 1965 in Brno, and has made a strong contribution to the rehabilitation of genetics generally, and to championing the work of Johann Gregor Mendel in particular. With Jaroslav Kříženecký, he cofounded the Mendelianum in Brno, which for decades has served as an intellectual bridge between the East and West. Orel's involvement with this institution exposed him to dangers both during and after the Cold War.

  3. Electrophysiological monitoring during preoperative angiography to guide decisions regarding permanent occlusion of major radicular arteries in patients undergoing total en bloc spondylectomy.

    PubMed

    Salame, Khalil; Maimon, Shimon; Regev, Gilad J; Kimchi, Tali Jonas; Korn, Akiva; Mangel, Laurence; Lidar, Zvi

    2016-08-01

    OBJECTIVE Preoperative embolization is performed before spine tumor surgery when significant intraoperative hemorrhage is anticipated. Occlusion of radicular and segmental arteries may result in spinal ischemia. The goal of this study was to check whether neurophysiological monitoring during preoperative angiography in patients scheduled for total en bloc spondylectomy (TES) of spine tumors improves the safety of vessel occlusion. METHODS This was a case series study of patients who underwent tumor embolization under somatosensory evoked potential (SSEP) and motor evoked potential (MEP) monitoring in preparation for TES in treating spine tumors. The angiography findings, the embolized vessels, and the results are presented. RESULTS Five patients whose ages ranged from 33 to 75 years and who had thoracic spine tumors are reported. Four patients suffered from primary tumor and 1 patient had a metastatic tumor. Radicular arteries at the tumor level, 1 level above, and 1 level below were permanently occluded when SSEPs and MEPs were preserved during temporary occlusion. No complications were encountered during or after the angiography procedure and embolization. CONCLUSIONS Temporary occlusion with electrophysiological monitoring during preoperative angiography may improve the safety of permanent radicular artery occlusion, including the artery of Adamkiewicz in patients undergoing TES for the treatment of spine tumors. PMID:27476843

  4. Vítězslav Orel (1926-2015): Gregor Mendel's biographer and the rehabilitation of genetics in the Communist Bloc.

    PubMed

    Paleček, Pavel

    2016-09-01

    At almost 90 years of age, we have lost the author of the founding historical works on Johann Gregor Mendel. Vítězslav Orel served for almost 30 years as the editor of the journal Folia Mendeliana. His work was beset by the wider problems associated with Mendel's recognition in the Communist Bloc, and by the way in which narratives of the history of science could be co-opted into the service of Cold War and post-Cold War political agendas. Orel played a key role in the organization of the Mendel symposium of 1965 in Brno, and has made a strong contribution to the rehabilitation of genetics generally, and to championing the work of Johann Gregor Mendel in particular. With Jaroslav Kříženecký, he cofounded the Mendelianum in Brno, which for decades has served as an intellectual bridge between the East and West. Orel's involvement with this institution exposed him to dangers both during and after the Cold War. PMID:27325060

  5. Creation of false pedicles and a neo-pelvis for lumbopelvic reconstruction following en bloc resection of an iliosacral chondrosarcoma with lumbar spine extension: technical note.

    PubMed

    Mendel, Ehud; Nathoo, Narendra; Scharschmidt, Thomas; Schmidt, Carl; Boehmler, James; Mayerson, Joel L

    2014-03-01

    En bloc resection with negative tumor margins remains the principal treatment option for control or cure of primary pelvic chondrosarcomas, as current adjuvant therapies remain ineffective. Iliosacral chondrosarcomas with involvement of the sciatic notch are sufficiently challenging tumors. However, when there is concomitant lumbar extension requiring resection of the pedicles to maintain negative surgical margins, transpedicular screw fixation is not possible, making reconstruction of the lumbopelvic junction extremely challenging. A patient with an iliosacral chondrosarcoma with lumbar spine extension is presented in this report to illustrate a novel lumbopelvic spinal construct. Following combined external pelvectomy and hemisacrectomy with contralateral L3-5 hemilaminectomy and ipsilateral pediculotomy, bicortical transvertebral body screws were substituted for the missing pedicles, resulting in the creation of "false pedicles," which were further supplemented with an autologous vascularized fibular strut graft from the amputated lower limb and applied to the lateral aspect of the vertebral bodies. The creation of false pedicles allowed for a robust reconstruction of the lumbopelvic junction, including maintaining pelvic ring integrity with a "neo-pelvis", creating a functional load-bearing construct adequate for early mobilization and ambulation. The biomechanical dynamics of this unique construct are also discussed.

  6. Le LHC, un tunnel cosmique

    ScienceCinema

    None

    2016-07-12

    Et si la lumière au bout du tunnel du LHC était cosmique ? En d’autres termes, qu’est-ce que le LHC peut nous apporter dans la connaissance de l’Univers ? Car la montée en énergie des accélérateurs de particules nous permet de mieux appréhender l’univers primordial, chaud et dense. Mais dans quel sens dit-on que le LHC reproduit des conditions proches du Big bang ? Quelles informations nous apporte-t-il sur le contenu de l’Univers ? La matière noire est-elle détectable au LHC ? L’énergie noire ? Pourquoi l’antimatière accumulée au CERN est-elle si rare dans l’Univers ? Et si le CERN a bâti sa réputation sur l’exploration des forces faibles et fortes qui opèrent au sein des atomes et de leurs noyaux, est-ce que le LHC peut nous apporter des informations sur la force gravitationnelle qui gouverne l’évolution cosmique ? Depuis une trentaine d’années, notre compréhension de l’univers dans ses plus grandes dimensions et l’appréhension de son comportement aux plus petites distances sont intimement liées : en quoi le LHC va-t-il tester expérimentalement cette vision unifiée ? Tout public, entrée libre / Réservations au +41 (0)22 767 76 76

  7. Tips and tricks of the surgical technique for borderline resectable pancreatic cancer: mesenteric approach and modified distal pancreatectomy with en-bloc celiac axis resection.

    PubMed

    Hirono, Seiko; Yamaue, Hiroki

    2015-02-01

    Borderline resectable (BR) pancreatic cancer involves the portal vein and/or superior mesenteric vein (PV/SMV), major arteries including the superior mesenteric artery (SMA) or common hepatic artery (CHA), and sometimes includes the involvement of the celiac axis. We herein describe tips and tricks for a surgical technique with video assistance, which may increase the R0 rates and decrease the mortality and morbidity for BR pancreatic cancer patients. First, we describe the techniques used for the "artery-first" approach for BR pancreatic cancer with involvement of the PV/SMV and/or SMA. Next, we describe the techniques used for distal pancreatectomy with en-bloc celiac axis resection (DP-CAR) and tips for decreasing the delayed gastric emptying (DGE) rates for advanced pancreatic body cancer. The mesenteric approach, followed by the dissection of posterior tissues of the SMV and SMA, is a feasible procedure to obtain R0 rates and decrease the mortality and morbidity, and the combination of this aggressive procedure and adjuvant chemo(radiation) therapy may improve the survival of BR pancreatic cancer patients. The DP-CAR procedure may increase the R0 rates for pancreatic cancer patients with involvement within 10 mm from the root of the splenic artery, as well as the CHA or celiac axis, and preserving the left gastric artery may lead to a decrease in the DGE rates in cases where there is more than 10 mm between the tumor edge and the root of the left gastric artery. The development of safer surgical procedures is necessary to improve the survival of BR pancreatic cancer patients.

  8. LeFort I Osteotomy

    PubMed Central

    Buchanan, Edward P.; Hyman, Charles H.

    2013-01-01

    The LeFort I osteotomy is one of the most commonly used procedures to correct midface deformities. It allows for correction in three dimensions including advancement, retrusion, elongation, and shortening. It is indicated, often in conjunction with mandibular surgery, for class II and III malocclusion, facial asymmetry, obstructive sleep apnea, and maxillary atrophy. Before surgery, proper orthodontics and surgical planning should be undertaken to ensure adequate outcomes. Overall, the surgery is widely used due to its low complication profile and reliable long-term results. PMID:24872761

  9. Le sevrage de l’allaitement

    PubMed Central

    Grueger, Barbara

    2013-01-01

    RÉSUMÉ L’allaitement exclusif assure une alimentation optimale aux nourrissons jusqu’à l’âge de six mois. Par la suite, les nourrissons ont besoin d’aliments complémentaires pour répondre à leurs besoins nutritionnels. C’est alors que le sevrage commence. Le sevrage désigne le processus graduel d’introduction d’aliments complémentaires au régime du nourrisson, tout en poursuivant l’allaitement. Il n’y a pas de moment universellement accepté ou scientifiquement démontré pour mettre un terme à l’allaitement. Le moment et le processus de sevrage doivent être adaptés par la mère et l’enfant. Le sevrage peut être soudain ou graduel, prendre plusieurs semaines ou plusieurs mois, être dirigé par l’enfant ou par la mère. Les médecins doivent orienter et soutenir les mères tout au long du processus de sevrage. Le présent document remplace le document de principes sur le sevrage qu’a publié la Société canadienne de pédiatrie en 2004.

  10. Le syndrome d'apert

    PubMed Central

    Benmiloud, Sarra; Chaouki, Sana; Atmani, Samir; Hida, Moustapha

    2013-01-01

    Le syndrome d'Apert est une affection congénitale rare, caractérisée par une sténose cranio-faciale associée à une syndactylie des mains et des pieds. Sa prise en charge doit être précoce et multidisciplinaire. Sa gravité réside dans la coexistence de plusieurs malformations avec un risque d'hypertension intracrânienne chronique responsable d'une cécité et d'une débilité mentale. Les auteurs rapportent une nouvelle observation à travers laquelle ils illustrent les aspects cliniques et évolutifs ainsi que les difficultés thérapeutiques de cette affection. PMID:23565313

  11. Profil épidémiologique des femmes enceintes cardiaques dans le centre de maternité de Tunis: expérience du service A

    PubMed Central

    Khemiri, Khaled; Jenayah, Amel Achour; Boudaya, Fethia; Hamdi, Asma; Meskhi, Souad; Sfar, Ezzeddine; Chelli, Dalenda

    2015-01-01

    Nous rapportons dans ce travail, le profil épidémiologique des femmes enceintes porteuses d'une cardiopathie ayant accouché dans le service «A» du centre de maternité de Tunis. Il s'agit d'une étude rétrospective descriptive sur 3 ans, de janvier 2010 à décembre 2012, portant sur les dossiers des parturientes cardiaques suivies et ayant accouché dans notre service, à l'exclusion des cardiopathies hypertensives. Les paramètres analysés étaient la gestité et parité des parturientes, le type de la cardiopathie, le mode d'accouchement et le pronostic foetal. Cinquante six cas sur 19655 accouchements avaient été recrutés, soit une incidence de 1 pour 351 accouchements (0,285%). L’âge moyen de nos parturientes était de 30,89±5,3 ans avec des extrêmes allant de 21 à 42 ans. 23 (41,07%) avaient une cardiopathie congénitale, 35 (62,5%) une valvulopathie, 6 (10,71%) un trouble du rythme, 3 (5,35%) un trouble de la conduction à type de bloc auriculo-ventriculaire et 3 (5,35%) une cardiopathie ischémique. Cinquante deux parturientes (92,85%) avaient accouché à un terme dépassant les 37 semaines d'aménorrhée (SA). L'accouchement s'est déroulé par les voies naturelles chez 22 (39,28%) patientes et par césarienne chez 34 (60,71%). Le poids moyen des nouveaux nés à la naissance était de 3341,25 grammes. 3 transferts néonataux en unité de réanimation étaient réalisés avec un seul cas de décès néonatal. La grossesse et l'accouchement chez la femme cardiaque constituent un haut risque materno-foetal dépendant du type, mais surtout du stade de la cardiopathie, nécessitant une prise en charge précoce et multidisciplinaire de la parturiente. PMID:26327977

  12. Performance of LE-7 LOX pump inducer

    NASA Astrophysics Data System (ADS)

    Kamijo, Kenjiro; Yamada, Hitoshi; Hashimoto, Ryohei; Tsujimoto, Yoshinobu

    A liquid oxygen turbopump has been developed for the main engine (LE-7) of the H-II rocket. The LE-7 LOX pump requires an inducer with quite high suction performance and high head, because a low-speed pump is not used ahead of the main pump in the LE-7 engine. The inducer was designed using the customary method and its hydraulic and mechanical performances were investigated in tests of LE-7 LOX turbopumps. The original combination of an inducer and an inducer housing satisfied the required hydraulic performance criteria. However, this combination was found to result in supersynchronous shaft vibrations due to rotating cavitation which occurred in the inducer. This problem was almost completely solved by a simple modification of the inducer upstream housing. Furthermore, the rotating cavitation of the present inducer was investigated using a new theory of such cavitation developed by Tsujimoto, et al.

  13. Jan Potocki et le "Gothic Novel"

    ERIC Educational Resources Information Center

    Finne, Jacques

    1970-01-01

    Establishes a parallel between the supernatural and fantastic qualities of Le Comte Jan Potocki's literary works, and the English gothic novels by comparing the elements of terror, mysterious atmosphere, and the supernatural beings involved. (DS)

  14. Fabrication de transistors mono-electroniques en silicium pour le traitement classique et quantique de l'information: une approche nanodamascene

    NASA Astrophysics Data System (ADS)

    Harvey-Collard, Patrick

    Les transistors mono-electroniques (SETs) sont des dispositifs ayant un grand potentiel d'applications, comme la detection de charge ultra-sensible, la logique a basse consommation de puissance, la memoire ou la metrologie. De plus, la possibilite de pieger un seul electron et de manipuler son etat de spin pourrait permettre des applications en informatique quantique. Le silicium est un materiau interessant pour fabriquer l'ilot d'un SET. Son gap semi-conducteur permet le fonctionnement du dispositif dans le regime a un seul electron ou trou et pourrait permettre d'etendre la plage d'operation du SET en temperature en augmentant l'energie d'addition du diamant central de la valeur du gap. En outre, le silicium beneficie de plus de quarante annees d'expertise en microfabrication et d'une compatibilite avec la technologie metal--oxyde--semi-conducteur complementaire (CMOS). Cependant, la fabrication de ces dispositifs fait face a de serieuses limitations a cause de la taille nanometrique requise pour l'ilot. A ce jour, les procedes de fabrication proposes permettant l'operation a la temperature ambiante sont trop peu reproductibles pour permettre des applications a grande echelle. Dans ce memoire de maitrise, la fabrication de transistors mono-electroniques en silicium (Si-SETs) pour le traitement classique et quantique de l'information est realisee avec un procede nanodamascene. Le polissage chimico-mecanique (CMP) est introduit comme etape clef de la fabrication du transistor, permettant le controle au nanometre pres (nanodamascene) de l'epaisseur du transistor. Cet outil permet la fabrication de dispositifs ayant une geometrie auparavant impossible a realiser et ouvre la porte a l'innovation technologique. De plus, un procede de gravure du silicium par plasma a couplage inductif (ICP) est developpe pour permettre la fabrication de nanostructures de silicium sur une nanotopographie alliant le nano et le 3D. Les Si-SETs fabriques sont caracterises a basse

  15. Entrevue avec le Dr Charley Zeanah

    PubMed Central

    2013-01-01

    Le Dr Charles Zeanah est titulaire de la chaire de psychiatrie Mary K. Sellars-Polchow, professeur de pédiatrie clinique et vice-président de la pédopsychiatrie au département de psychiatrie et des sciences du comportement de la faculté de médecine de l’Université Tulane, à la Nouvelle-Orléans. Il est également directeur général de l’institut de la santé mentale des nourrissons et des jeunes enfants de Tulane. Il est récipiendaire de nombreux prix, notamment le prix de prévention Irving Phillips (AACAP), la mention élogieuse présidentielle pour sa recherche et son leadership exceptionnels en santé mentale des nourrissons (American Orthopsychiatric Association), le prix d’excellence clinique Sarah Haley Memorial (International Society for Traumatic Stress Studies), le prix de recherche en pédopsychiatrie Blanche F. Ittelson (APA), et le prix Serge Lebovici Award soulignant les contributions internationales à la santé mentale des nourrissons (World Association for Infant Mental Health). Le Dr Zeanah est fellow distingué de l’AACAP, fellow distingué de l’APA et membre du conseil d’administration de Zero to Three. Il est l’éditeur scientifique de Handbook of Infant Mental Health (3e édition) qui est considéré comme étant le manuel de pointe et la référence de base du domaine de la santé mentale des nourrissons.

  16. Faut-il continuer à infiltrer le scalp par un anesthésique local pour une craniotomie?

    PubMed Central

    Doumiri, Mouhssine; Motiaa, Youssef; Razine, Rachid; Amor, Morad; Moussaoui, Abdelmajid; Kabbaj, Saad; Maazouzi, Wajdi

    2015-01-01

    Introduction Le maintien de la stabilité hémodynamique est un objectif primordial de l'anesthésie pour craniotomie. Peu d’études ont prouvé l'efficacité de l'infiltration du scalp par un anesthésique local pour le maintien de la stabilité hémodynamique après l'incision. L'objectif de notre travail est d’évaluer l'influence de l'infiltration de la ligne d'incision du scalp par la lidocaïne à 0,5% adrénalinée sur les paramètres hémodynamiques après incision pour craniotomie supratentorielle. Méthodes Étude prospective en double aveugle réalisée au bloc opératoire de l'hôpital des spécialités de Rabat sur une période d'une année incluant 80 malades programmés pour craniotomie supratentorielle. Les malades étaient randomisés par tirage au sort en 2 groupes: Le groupe 1 était infiltré par 40 ml du sérum salé adrénaliné (1/200 000) et le groupe 2 était infiltré par 40 ml de la lidocaïne 0,5% adrénalinée (1/200 000). Le critère de jugement principal était la pression artérielle moyenne (PAM) après l'incision. L’étude statistique a fait appel aux tests t de student et l'U- mann-whitney. Une valeur de p <0.05 était considérée significative. Résultats L’étude a inclus 80 patients (40 hommes et 40 femmes). L’âge moyen était 42,33±14,76 ans. Le poids moyen était 71,58 ±10 kg. Le 3/4 des patients était ASA 1, seulement 25% étaient ASA2. La durée moyenne de la chirurgie était de 252,06±38,62 mn. Les deux groupes étaient comparables concernant l’âge, le sexe, le poids, la durée d'intervention, le type d'abord chirurgical, la dose totale du fentanyl reçue jusqu'a l'incision, ainsi que les paramètres hémodynamiques avant l'incision. Après l'incision la FC moyenne a augmenté dans les deux groupes: 80,53±7,72 bpm dans le groupe contrôle et 76,85±8,52 bpm dans le groupe lidocaïne. La différence d'augmentation de la FC entre les deux groupes était statistiquement significative (p = 0,047). L

  17. Les Brulures Chimiques Par Le Laurier Rose

    PubMed Central

    Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.

    2010-01-01

    Summary Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose de gravité différente. Cela doit aboutir à une information élargie de la population, ainsi qu'une réglementation stricte de sa commercialisation. PMID:21991211

  18. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-09-01

    Jeunes étoiles et vieilles galaxies; Chiens de Chasse; Des images en partie belges; Détection chimique de planètes?; Amas cannibale; Le pulsar œil de bœuf; Supernova 2002 DJ; Centaurus A; Et de cent; Près du trou noir; Un cratère sous la Merdu Nord; Des astéroï des frôlent la Terre; Photons fatigués; Taches solaires; Un grand lac martien; Les naines brunes en infrarouge; Bourrelet équatorial; Fusion de trous noirs; Le hamburger de Gomez; Matière sombre; Non aux étoiles à quarks

  19. Le continu contre l'espace

    NASA Astrophysics Data System (ADS)

    Salanskis, Jean-Michel

    Disons pour conclure que, en tout état de cause, la façon de concevoir philosophiquement le conflit du continu et de l'espace que nous avons trouvée chez Hegel n'est pas homogène avec le style et les modalités de la pensée mathématique: 1) d'une part, le lien classique, le lien de référence entre continu et espace en mathématiques n'est pas que l'espace serait premier et privé de pensée, et le continu second, venant dissoudre l'espace en apportant la qualité, l'infini et la pensée, mais tout au contraire, il consiste en ce que l'espace est fondé sur l'abîme infinitaire du continu ; 2) d'autre part, l'éventuel divorce entre l'espace et le continu dans l'aire mathématique n'est pas celui d'une réflexivité purement conceptuelle du continu avec un positivisme géométrique, n'équivaut pas à une rupture disciplinaire ; il est plutôt le symptôme de la dérive d'une herméneutique à l'égard d'une autre, au sein d'un continent juridique commun définissant la discipline (la mathématique ensembliste), cette dérive pouvant, à la limite, induire une refonte de ce sol juridique, sans que jamais il soit question pour autant de nier l'unité des mathématiques, à comprendre ici comme l'unité ultime de responsabilité de la communauté mathématique à l'égard des trois questions Qu'est-ce que l'espace?”, “Qu'est-ce que le continu?” et “Qu'est-ce que l'infini?”.

  20. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2014-06-01

    Future lune ? - L'âge de la Lune - Des volcans actifs sur Vénus - Un lac dans le cratère Gusev ? - Météorites et atmosphère martiennes - L’hexagone de Saturne - Pluton - Exo-Terre - Bêta Pictoris b - Cérès et Vesta depuis Mars - Naine froide - Parallaxes par Hubble - L2 Puppis et le sort du Soleil - Supernova et lentille gravitationnelle - Champ magnétique galactique - L’objet de Sakurai - Fermi et la matière noire - Lentille naine

  1. 30. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE, LE CLAIRE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE, LE CLAIRE BASE COMPOUND, LOOKING EAST - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  2. 29. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE BUILDING, LE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. INTERIOR VIEW OF MISSISSIPPI RIVER RECREATION OFFICE BUILDING, LE CLAIRE BASE COMPOUND, LOOKING WEST - Mississippi River 9-Foot Channel, Lock & Dam No. 14, Upper Mississippi River, Le Claire, Scott County, IA

  3. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2001-04-01

    Les étoiles massives nouvellement nées secouent leur berceau; Première observation de la matière sombre; Le bruit cosmique X; L'âge de l'univers; Supernova record; Premiers pas en interférométrie;

  4. Microscopic Description of Le Chatelier's Principle

    ERIC Educational Resources Information Center

    Novak, Igor

    2005-01-01

    A simple approach that "demystifies" Le Chatelier's principle (LCP) and simulates students to think about fundamental physical background behind the well-known principles is presented. The approach uses microscopic descriptors of matter like energy levels and populations and does not require any assumption about the fixed amount of substance being…

  5. Le Chatelier's Principle, Temperature Effects, and Entropy.

    ERIC Educational Resources Information Center

    Campbell, J. Arthur

    1985-01-01

    One of the most useful methods of understanding chemical equilibria is provided by Le Chatelier's principle. The relationships between this principle, temperature, and entropy are discussed. Tables with thermodynamic data for some net reactions commonly used to illustrate the principle and for reactions involving gases are included. (JN)

  6. Le Chatelier's principle in replicator dynamics

    NASA Astrophysics Data System (ADS)

    Allahverdyan, Armen E.; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition.

  7. Le Chatelier's principle in replicator dynamics.

    PubMed

    Allahverdyan, Armen E; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition. PMID:22181097

  8. Le Chatelier--Right or Wrong?

    ERIC Educational Resources Information Center

    Helfferich, Friedrich G.

    1985-01-01

    Presents a class exercise designed to find out how well students understand the nature and consequences of the mass action law and Le Chatelier's principle as applied to chemical equilibria. The exercise relates to a practical situation and provides simple relations for maximizing equilibrium quantities not found in standard textbooks. (JN)

  9. Le Francais Courant: Part V, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Courant: Part 5" focus on the development of mastery of the basic numbering system and other grammatical structures. Structures include the formation of the present tense of the irregular verbs "vouloir,""pouvoir," and "venir,"…

  10. Le Francais Moderne: Part I, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Moderne: Part 1" focus on the development of vocabulary and mastery of grammatical structures. The formation of the passe compose with "avoir," object pronouns, the present tense of regular "-ir" verbs, and the irregular verbs…

  11. A Colorful Demonstration of Le Chbtelier's Principle.

    ERIC Educational Resources Information Center

    Last, Arthur M.; Slade, Peter W.

    1997-01-01

    Le Chbtelier's Principle states that, when a system at equilibrium is subjected to stress, the system will respond in such a way as to minimize the effect of the stress. Describes a lecture demonstration that illustrates shifts in the position of equilibrium caused by a variety of factors. The equilibrium mixture contains iron (III) and…

  12. Le syndrome d’alcoolisme foetal

    PubMed Central

    2002-01-01

    L’alcool est un tératogène physique et comportemental. Le syndrome d’alcoolisme foetal (SAF) est un trouble courant mais encore sous-diagnostiqué découlant de la consommation d’alcool par la mère pendant la grossesse. Bien qu’il puisse être prévenu, le SAF est également invalidant. Même si le SAF est présent dans tous les groupes socioéconomiques du Canada, sa prévalence est élevée dans certaines communautés inuites et des Premières nations du Canada. Le présent énoncé porte sur la prévention, le diagnostic, le dépistage précoce et la prise en charge du SAF par les professionnels de la santé. La prévention du SAF doit s’effectuer à deux échelons. La prévention primaire consiste à éliminer le SAF par une formation en classe ou dans la collectivité et à inciter les femmes à éviter de consommer de l’alcool avant la conception et pendant la grossesse. La prévention secondaire consiste à repérer les femmes qui boivent pendant leur grossesse et à réduire leur consommation. Le présent énoncé décrit plusieurs stratégies de dépistage, dont la stratégie T-ACE (tolérance-agacement, réduction, éveil). Les dispensateurs de soins devraient recommander l’abstinence dès la première visite prénatale. Un envoi rapide en consultation en vue de traiter l’alcoolisme est recommandé pour les femmes enceintes incapables d’arrêter de boire. Le présent énoncé décrit le diagnostic de SAF, de SAF partiel ou atypique, d’anomalies congénitales et de troubles neurodéveloppementaux reliés à l’alcool. En cas d’exposition à l’alcool in utero, un diagnostic de SAF devrait être envisagé en présence d’un retard de croissance courant ou antérieur, de certaines anomalies faciales touchant la lèvre supérieure et les yeux et d’anomalies neurodéveloppementales. Ces caractéristiques sont mieux quantifiées au moyen d’une méthode diagnostique à quatre chiffres. Des stratégies de dépistage précoce des

  13. Le syndrome d’alcoolisme foetal

    PubMed Central

    2002-01-01

    L’alcool est un tératogène physique et comportemental. Le syndrome d’alcoolisme foetal (SAF) est un trouble courant mais encore sous-diagnostiqué découlant de la consommation d’alcool par la mère pendant la grossesse. Bien qu’il puisse être prévenu, le SAF est également invalidant. Même si le SAF est présent dans tous les groupes socioéconomiques du Canada, sa prévalence est élevée dans certaines communautés inuites et des Premières nations du Canada. Le présent énoncé porte sur la prévention, le diagnostic, le dépistage précoce et la prise en charge du SAF par les professionnels de la santé. La prévention du SAF doit s’effectuer à deux échelons. La prévention primaire consiste à éliminer le SAF par une formation en classe ou dans la collectivité et à inciter les femmes à éviter de consommer de l’alcool avant la conception et pendant la grossesse. La prévention secondaire consiste à repérer les femmes qui boivent pendant leur grossesse et à réduire leur consommation. Le présent énoncé décrit plusieurs stratégies de dépistage, dont la stratégie T-ACE (tolérance-agacement, réduction, éveil). Les dispensateurs de soins devraient recommander l’abstinence dès la première visite prénatale. Un envoi rapide en consultation en vue de traiter l’alcoolisme est recommandé pour les femmes enceintes incapables d’arrêter de boire. Le présent énoncé décrit le diagnostic de SAF, de SAF partiel ou atypique, d’anomalies congénitales et de troubles neurodéveloppementaux reliés à l’alcool. En cas d’exposition à l’alcool in utero, un diagnostic de SAF devrait être envisagé en présence d’un retard de croissance courant ou antérieur, de certaines anomalies faciales touchant la lèvre supérieure et les yeux et d’anomalies neurodéveloppementales. Ces caractéristiques sont mieux quantifiées au moyen d’une méthode diagnostique à quatre chiffres. Des stratégies de dépistage précoce des

  14. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2003-09-01

    Système solaire poussiéreux; Combien d'étoiles dans le ciel?; Distance d'un pulsar; Planètes poussières et métaux; Un amateur belge bat les professionnels; Matière sombre; Supernova asymétrique; Anneau liégeois; Amas globulaires; Amas globulaires vagabonds; Baptême de satellites; Champ de gravité terrestre; Début de l'univers; XMM et Geminga; Carte neutrinos du ciel; Galaxies et trous noirs; Univers X; SMART-1: signal de départ pour l'aventure lunaire; Les saisons de Pluton; Planète dans M4; Rotation des pulsars; Un jumeau de Jupiter?; Le satellite ISO; Mars Express~:dernier clin d'oeil à la Terre; Waterworld: une réalité?

  15. Le matérialisme scientifique

    NASA Astrophysics Data System (ADS)

    Meunier, Jean-François

    2004-03-01

    De nos jours, il arrive quotidiennement aux grands hommes d'avoir à fréquenter d'ignorants mortels épris d'une conviction maladive que la science est la grande responsable de tous les maux du monde. Évidemment sans physique atomique, il n'y aurait pas eu d'Hiroshima et sans révolution industrielle, pas de pollution et etc. Cependant, ces accusations envers le progrès technique sont tout à fait injustes, irréfléchies et, j'irai même jusqu'à dire, irresponsables, puisque le calcul, i.e. la planification, même la plus élémentaire, est ce qui caractérise le mieux, pragmatiquement, la société humaine. À mon avis, les problèmes sociaux tireraient plutôt leur origine de sciences sociales irréalistes, qui, concrètment, inspireraient ou serviraient d'alibis à ceux qui détiennent véritablement le pouvoir. Dans cet article, je tenterai donc de démontrer la meilleure véracité et efficacité du matérialisme scientifique. Cette doctrine, dont Mario Bunge est le plus illustre représentant, s'appuy sur les résultats théoriques et expérimentaux des sciences factuelles ainsi que sur l'exactitude logique des mathématiques, utilisées ici comme langage universel de l'expression des idées. Cette conception philosophique qui s'inspire principalement du modèle des théories physiques, stipule que les réalités sociales sont, comme tout autre réalité, matérielles, mathématisables et représentables comme des systèmes en interaction. En fait, le modèle des physiciens ayant historiquement fait ses preuves en matière de testabilité et de cohérence interne est proposé d'être appliquer aux sciences sociales, aujourd'hui scindées des sciences dites pures sous l'inspiration des pseudo penseurs néo-kantiens, phénoménologiques et post-moderne. Cette nouvelle approche permettrait ainsi d'évoluer plus exactement vers une compréhension des bases sociales et biologiques du comportement humain afin de développer une éthique sans cesse plus r

  16. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2002-06-01

    Loi tchèque sur la pollution lumineuse; XTE J0929-314; Futurs amas de galaxies; Palomar 5; La météo des naines brunes; Trous noirs et galaxies elliptiques; Europe; 2MASS; Mars; Io; Matière sombre; Un objet très froid; Les oscillations stellaires; Un système lanétaire en formation; Binaire serrée; Satellites de Jupiter; Mars sous la loupe; Le Hubble nouveau

  17. Two further comments on Durkheim's Le Suicide.

    PubMed

    Andriessen, Karl

    2007-01-01

    It appears that the publications of Goldney and Schioldann (2000, 2001a,b, 2002) touched a chord, namely, the quality of the basic literature of contemporary suicidology and the usage of certain words and concepts. This paper adds two comments to this discussion. The first comment focuses on the usage of "altruistic," "egoistic," and "anomic" suicide. The second is a comment on the reception of Le Suicide.

  18. Les Troubles Respiratoires Chez Le Brule

    PubMed Central

    Fassi Fihri, J.; Ezzoubi, M.; Boukind, E.H.

    2010-01-01

    Summary A travers une revue de la littérature, cet article se propose d'exposer les particularités des troubles respiratoires chez le brûlé. Ces troubles sont liés à un mécanisme direct, lorsque l'arbre respiratoire est lésé par le transfert d'énergie thermique du à la brûlure et/ou par un mécanisme indirect, lorsque la fonction respiratoire et ventilatoire du poumon est perturbée par les phénomènes loco-régionaux ou généraux du brûlé. Ces troubles respiratoires sont aggravés par l'inhalation des gaz contenus dans la fumée d'incendie. Le diagnostic de ces troubles est clinique et paraclinique. Il doit être précoce et continu. Les patients nécessitent de différents moyens thérapeutiques tels que l'oxygénothérapie, la libération des voies respiratoires, l'amélioration de la mécanique ventilatoire et de la fonction respiratoire, l'antibiothérapie ou la chirurgie des séquelles. Cette prise en charge doit nécessairement être multidisciplinaire. PMID:21991224

  19. Completion of nonreducible Le Fort fractures by Le Fort I osteotomy: sometimes an inevitable choice to avoid postoperative malocclusion.

    PubMed

    Scolozzi, Paolo; Imholz, Benoît

    2015-01-01

    The aim of this study was to prospectively evaluate the use of a simultaneous Le Fort I osteotomy for completion of nonreducible Le Fort fractures. We analyzed the clinical and radiological data of 44 patients with Le Fort fractures, 9 of whom presented with a nonreducible type. Seven patients with an incomplete Le Fort I fracture had a contralateral Le Fort I osteotomy, and 2 patients with an incomplete Le Fort III fracture had a true bilateral Le Fort I-type osteotomy. We recorded age and sex, mechanism of injury, level of Le Fort fracture, concomitant mandibular fractures, concomitant maxillomandibular fixation (MMF) and its duration, surgical approach, status of healing, and complications. Follow-ups were at 1 week and 1, 3, 6, and 12 months.All patients recovered their normal pretrauma occlusion without the need for postoperative elastic guidance, except for 1 patient who required light class III traction elastics for 3 weeks to achieve the correct occlusion. None of the patients presented with intraoperative or postoperative complications.The present study has demonstrated that completion of nonreducible Le Fort fractures by Le Fort I osteotomy results in a high rate of success.

  20. [R0 Resection by Distal Pancreatectomy with En Bloc Celiac Axis Resection after Down-Staging by FOLFIRINOX Therapy in a Case of Pancreas Cancer--Report of a Case].

    PubMed

    Makino, Hironobu; Kametaka, Hisashi; Fukada, Tadaomi; Seike, Kazuhiro; Koyama, Takashi; Hasegawa, Akio

    2015-11-01

    The patient, a 55-year-old man, was diagnosed elsewhere as having cancer of the tail of the pancreas and was referred to our hospital. Abdominal computed tomography (CT) revealed a remarkably large tumor, 90 mm in diameter, in the tail of the pancreas, with invasion of the adjacent spleen, stomach, left adrenal gland, diaphragm, and celiac artery; metastasis to the liver; and peritoneal dissemination. The serum levels of the tumor markers CEA and CA19-9 were elevated (21.2 ng/mL and 9,530 U/mL, respectively). Since surgery was not considered to be feasible in this condition, the patient was started on FOLFIRINOX therapy. Adverse events, including Grade 3 decreased neutrophil count, anorexia, diarrhea, and hyperkalemia occurred; however, the patient was able to receive 10 cycles of therapy with downward adjustments of the dosage. In response to the therapy, the tumor marker levels fell rapidly, and on CT, the tumor shrank to 40 mm in diameter; however, resection was still scheduled because positron emission tomography (PET)-CT revealed suspected remnants of the disease in the pancreatic tail. After preoperative transcatheter embolization of the common hepatic artery and the left gastric artery, distal pancreatectomy with en bloc celiac axis resection (DP-CAR) was performed. Intraoperative ultrasonography revealed no metastatic lesions in the liver. Histopathologically, the resected sites were found to be almost totally replaced with fibrous scar tissue, and only trace evidence of moderately differentiated tubular adenocarcinoma components were seen in the pancreatic tail, gastric submucosa, and left adrenal gland. Therefore, R0 resection had been achieved. The patient remains alive, showing no signs of recurrence at 18 months after the initial treatment and 11 months after the tumor resection. The results in this case suggest that FOLFIRINOX therapy can increase the radical curability of pancreatic cancer via down-staging and eventually improve the prognosis. PMID

  1. Le transfert de connaissances entre les mathematiques et les sciences. Une etude exploratoire aupres d'eleves de 4e secondaire

    NASA Astrophysics Data System (ADS)

    Samson, Ghislain

    2003-06-01

    Au moment ou dans plusieurs pays on travaille a refondre les programmes d'etudes, tant au primaire qu'au secondaire, l'interet pour le transfert renait. Un des concepts fondamentaux en apprentissage consiste en l'habilete a reutiliser de facon consciente et efficace un acquis d'une situation a une autre situation. Cette recherche emane de preoccupations professionnelles au moment ou le chercheur etait enseignant au secondaire. Au cours de ces annees, il lui a ete possible de constater que plusieurs eleves percevaient difficilement les liens presents entre les disciplines mathematiques et scientifiques. Des travaux en psychologie cognitive et plus particulierement selon une perspective du traitement de l'information ont servi de cadre de reference pour evaluer et analyser les capacites de transfert aupres d'eleves de 4e secondaire. Ce cadre de reference permet de formuler le principal objectif qui est de mieux comprendre le processus de transfert chez des eleves en situation de resolution de problemes scientifiques. Cette these s'interesse donc au transfert en tant que phenomene important du processus d'apprentissage au sens de l'integration. La methode de recherche choisie, de nature qualitative, est principalement axee sur l'evaluation de la capacite a transferer des connaissances lors d'une epreuve et d'un entretien. Pour evaluer ce potentiel de transfert, nous avons elabore deux outils: une epreuve en mathematiques et en sciences et un guide d'entretien. Pour la passation de l'epreuve, le chercheur a pu compter sur la collaboration de 130 sujets provenant de deux ecoles. L'entretien complete la prise de donnees avec 13 sujets ayant accepte de poursuivre l'etude. Les donnees recueillies par ces instruments font ensuite l'objet d'une analyse de contenu. En premier lieu, les verbatims de l'epreuve et de l'entretien ont ete transcrits, puis codifies. La correction des reponses fournies pour les problemes resolus s'est faite a partir d'une grille d

  2. René Le Fort 1869-1951.

    PubMed

    Noffze, Michael J; Tubbs, R Shane

    2011-04-01

    Over a century ago, The French surgeon René Le Fort described the anatomical basis for fractures of the mid-face. His nomenclature is still used today using the eponym "Le Fort fractures." Although Le Fort's name is well known in association with the fractures that he described, little is known of his life. Therefore, the present article will discuss the background of this important individual in craniofacial trauma.

  3. Le déficit immunitaire humoral: mieux le connaître pour mieux le prendre en charge

    PubMed Central

    El Bakkouri, Jalila; Aadam, Zahra; Ailal, Fatima; Alj, Hanane Salih; Bousfiha, Ahmed Aziz

    2014-01-01

    Les déficits immunitaires humoraux (DIH) sont des maladies hétérogènes allant des formes asymptomatiques rencontrés lors des déficits sélectifs en immunoglobulines A (IgA) et en sous-classes d'IgG aux formes graves des agammaglobulinémies congénitales. Les patients atteints de DIH présentent souvent des infections ORL ou des voies respiratoires récidivantes ou sévères. Ces patients peuvent présenter un certain nombre de complications non infectieuses, telles que des manifestations auto-immunes et des entéropathies, qui pourraient être le seul symptôme clinique révélateur. Les formes sévères des DIH sont facilement diagnostiquées grâce au dosage des IgG totaux, des IgA et des IgM. La thérapie substitutive par les immunoglobulines reste le traitement de choix chez ces patients. PMID:25489366

  4. Trois inconnues qui bouleversent le Big Bang

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    2002-10-01

    Deux coups de tonnerre gigantesques dans le ciel de la cosmologie ont très récemment chamboulé notre vision de l'univers. Avec l'apparition d'une mystérieuse énergie sombre et la confirmation de la platitude de l'Univers, toutes les théories sur son évolution sont à revoir. Aujourd'hui l'Univers n'a plus de visage et tout est à reconstruire. Retour sur une histoire à rebondissements.

  5. Le Chatelier's principle with multiple relaxation channels

    NASA Astrophysics Data System (ADS)

    Gilmore, R.; Levine, R. D.

    1986-05-01

    Le Chatelier's principle is discussed within the constrained variational approach to thermodynamics. The formulation is general enough to encompass systems not in thermal (or chemical) equilibrium. Particular attention is given to systems with multiple constraints which can be relaxed. The moderation of the initial perturbation increases as additional constraints are removed. This result is studied in particular when the (coupled) relaxation channels have widely different time scales. A series of inequalities is derived which describes the successive moderation as each successive relaxation channel opens up. These inequalities are interpreted within the metric-geometry representation of thermodynamics.

  6. Le spasme du sanglot chez les nourrissons

    PubMed Central

    Goldman, Ran D.

    2015-01-01

    Résumé Question Des enfants qui fréquentent ma clinique ont des épisodes semblables à des convulsions pendant lesquels ils pleurent et retiennent leur souffle au point de faire survenir une cyanose et de perdre conscience. Les résultats à l’examen ou aux investigations sont normaux et les pédiatres consultés ne font pas d’autres investigations. Les spasmes du sanglot sont-ils communs et quels genres d’investigations faut-il faire? Réponse Le spasme du sanglot est un trouble non épileptique paroxysmal bénin qui se produit chez les enfants en santé de six à 48 mois. Les épisodes commencent par une provocation, comme un bouleversement émotionnel ou une blessure mineure, et peuvent progresser en une retenue de la respiration, une cyanose et une syncope. Les épisodes sont extrêmement effrayants à regarder mais ont des conséquences bénignes. Une fois le diagnostic clinique posé, on recommande de faire passer un électrocardiogramme et d’exclure la possibilité d’une anémie, mais aucune autre investigation ou demande de consultation n’est nécessaire.

  7. Insights: Simple Models for Teaching Equilibrium and Le Chatelier's Principle.

    ERIC Educational Resources Information Center

    Russell, Joan M.

    1988-01-01

    Presents three models that have been effective for teaching chemical equilibrium and Le Chatelier's principle: (1) the liquid transfer model, (2) the fish model, and (3) the teeter-totter model. Explains each model and its relation to Le Chatelier's principle. (MVL)

  8. L'astronomie dans le monde

    NASA Astrophysics Data System (ADS)

    Manfroid, J.

    2009-10-01

    Dunes de Titan; Lac Ontario; Titan; Anneaux de Saturne; Jupiter; Mars; Rotation de Saturne; Valles Marineris; Méthane martien; Epsilon Aurigae; Glycine cométaire; HD 87643; Pluton; Bételgeuse; Site astronomique; Andromède cannibale; Attaque de trou noir; BD+44 493; Formation d'étoiles; Gaz manquant; LIGO; M87; Naine blanche; Galaxie satellite; Galaxies naines sphéroïdales; Galaxies trapues; Cygnus X-1; L'avenir de la Voie Lactée; Naphtaline cosmique; Premiers trous noirs; Coup de foudre; Effet de serre; Glace lunaire; Impacts et extinctions; Exoplanètes rétrogrades; Kepler; Planète chaude; Collision planétaire; Disques dans le vent; Exoplanètes; Formation des planètes; Taches et transits

  9. The Use of Le by L1 Chinese Speakers and the Acquisition of Le by L2 Chinese Learners

    ERIC Educational Resources Information Center

    Bredeche, Chi Chen

    2011-01-01

    The perfective marker V-"le" is claimed to be one of the most problematic items in the acquisition of L2 Chinese, perhaps because no unified and comprehensive treatment of it exists in the literature. Although much has been written on this topic, the semantic and pragmatic functions of V-"le" have remained elusive. While linguists and grammarians…

  10. Le contrôle des infections au cabinet du pédiatre

    PubMed Central

    2008-01-01

    RÉSUMÉ La transmission des infections au cabinet du pédiatre est de plus en plus préoccupante. Le présent document expose les voies de transmission des infections et les principes sous-jacents aux mesures actuelles pour contrôler les infections. Pour prévenir les infections, il faut bien concevoir le cabinet et adopter des politiques administratives et de triage convenables, de même que des pratiques de base pour les soins de tous les patients (p. ex., hygiène des mains, port de gants, de masques, de lunettes de protection et d’une blouse d’hôpital pour des interventions précises; nettoyage, désinfection et stérilisation convenables des surfaces et du matériel, y compris les jouets, et techniques d’asepsie en cas d’interventions effractives) et des précautions additionnelles en cas d’infections précises. Le personnel doit avoir reçu les vaccins pertinents, et les personnes infectées doivent respecter les politiques de restriction au travail.

  11. Automated Verification of Design Patterns with LePUS3

    NASA Technical Reports Server (NTRS)

    Nicholson, Jonathan; Gasparis, Epameinondas; Eden, Ammon H.; Kazman, Rick

    2009-01-01

    Specification and [visual] modelling languages are expected to combine strong abstraction mechanisms with rigour, scalability, and parsimony. LePUS3 is a visual, object-oriented design description language axiomatized in a decidable subset of the first-order predicate logic. We demonstrate how LePUS3 is used to formally specify a structural design pattern and prove ( verify ) whether any JavaTM 1.4 program satisfies that specification. We also show how LePUS3 specifications (charts) are composed and how they are verified fully automatically in the Two-Tier Programming Toolkit.

  12. Impact de la varicocèle sur le volume testiculaire et les paramètres spermatiques

    PubMed Central

    Benazzouz, Mohamed Hicham; Essatara, Younes; El Sayegh, Hachem; Iken, Ali; Benslimane, Lounis; Nouini, Yassine

    2014-01-01

    Introduction La varicocèle est une pathologie masculine fréquente dont l'incidence est encore plus importante dans dans la population des hommes infertiles. Si ses mécanismes sont à ce jour incomplètement expliqués il semble acquis que la varicocèle peut être associée a une dysfonction testiculaire avec diminution du volume testiculaire et de la concentration en spermatozoïde de l’éjaculat. Méthodes Dans un premier temps nous exposons les résultats d'une étude rétrospective sur 5 ans (de Mars 2009 à Mars 2014), réalisée au service d'urologie A de l'hôpital Ibn Sina de Rabat et ayant comme objectif d’évaluer l'impact de la varicocèle palpable sur le volume testiculaire et les paramètres spermatiques. Tous les patients inclus dans notre étude avaient une varicocèle palpable. Dans un deuxième temps, et à travers une revue de la littérature nous discutons l'impact du traitement de la varicocèle sur la fertilité. Résultats 39 patients ont été inclus dans notre étude. L’âge moyen était de 29,71 ans et la varicocèle siégeait dans 89,74% des cas du coté gauche. Une atrophie testiculaire homolatérale à la varicocèle était retrouvée dans 7% des cas alors que des anomalies du spermogramme se voyaient dans 69,23% des cas. Conclusion L'impact de la varicocèle sur l'altération des paramètres spermatiques a été clairement établi bien que sa physio pathogénie ne soit pas bien élucidée. Le traitement chirurgical de la varicocèle semble indiqué chez les hommes infertiles présentant une varicocèle clinique et une altération significative du sperme. PMID:25918574

  13. Le point sur les amas de galaxies

    NASA Astrophysics Data System (ADS)

    Pierre, M.

    galaxies jouent donc un rôle de premier plan dans toute étude cosmologique et par conséquent, sont indispensables à notre compréhension globale de l'univers. Dans l'introduction générale, nous détaillons cet aspect fondamental en montrant comment l'étude des amas peut contribuer à contraindre les scénarios cosmologiques. Une fois le contexte scientifique délimité, les chapitres suivants s'attachent à présenter les diverses propriétés des amas et leur évolution cosmique observée dans diverses longueurs d'onde principalement dans les domaines visible (galaxies), X (gaz) et radio (gaz et particules). Nous verrons que l'étude détaillée d'un amas implique celle de l'interaction entre ses différentes composantes et est un passage obligé pour remonter au paramètre ultime (ou premier) qu'est sa masse. Loin d'être un détour ennuyeux, ceci sera l'occasion d'aborder des phénomènes physiques extrêmement variés tel l'aspect multi-phases du milieu intra-amas, les sursauts de formation d'étoiles et l'évolution morphologique des galaxies capturées par les amas, ou bien encore, l'interaction entre le plasma intra-amas et les particules relativistes accélérées lors de la fusion entre deux amas. Bien sûr, pour chaque longueur d'onde, nous ne manquerons pas de décrire simplement les techniques d'observation et d'analyse mises en oeuvre ; celles-ci sont particulièrement intéressantes dans le cas de l'instrumentation spatiale. Nous terminerons en présentant des projets d'observatoires pour l'horizon 2010 et leur impact prévu sur l'étude des amas de galaxies.

  14. Lymphoscintigraphy (LS) in lymphedema (LE) of the extremities

    SciTech Connect

    Gloviczki, P.; Vaqueiro, M.; Fisher, J.; Schirger, A.; Dewanjee, M.K.; Hollier, L.H.; Wahner, H.W.

    1985-05-01

    Twenty-two patients with primary and secondary LE and one with lipedema had LS using 0.4-0.6 mCi of Tc-99mSb2Sb3 subcutaneous at the second interdigital space. Three had excisional surgery, in four patients lympho-venous anastomosis (LVA) was attempted following LS. Results are presented in this paper. This study concludes that LS is a noninvasive method without side effects that visualizes the pattern of the lymphatic system in LE. If lymph channels were seen, LVA could be performed. LS seems adequate for patient selection and follow-up after LVA. It differentiated LE from lipedema. Image patterns or quantitative studies could not differentiate between primary and secondary LE.

  15. Microscopic Description of Le Châtelier's Principle

    NASA Astrophysics Data System (ADS)

    Novak, Igor

    2005-08-01

    The analysis based on microscopic descriptors (energy levels and their populations) is given that provides visualization of free energies and conceptual rationalization of Le Châtelier's principle. The misconception "nature favors equilibrium" is highlighted.

  16. The genus Trichocnemis LeConte, 1851 (Coleoptera, Cerambycidae, Prioninae)

    PubMed Central

    Swift, Ian; Santos-Silva, Antonio; Nearns, Eugenio H.

    2010-01-01

    Abstract The history of the genus Trichocnemis LeConte, 1851 (Coleoptera, Cerambycidae, Prioninae) is discussed. Its taxonomic status in relation to the genera Ergates Audinet-Serville, 1832 and Callergates Lameere, 1904 is clarified. The synonymy of Macrotoma californica White, 1853, Macrotoma spiculigera White, 1853, and Trichocnemis spiculatus LeConte, 1851 is confirmed. A key to all three genera and their species is provided. PMID:21594014

  17. Transmaxillary Sinus Approach for Le Fort II Osteotomy.

    PubMed

    Kobayashi, Shinji; Fukawa, Toshihiko; Hirakawa, Takashi; Satake, Toshihiko; Maegawa, Jiro

    2016-02-01

    The Le Fort II osteotomy is a relatively rare operation. The posterior wall osteotomy of the maxillary sinus (MS) is often difficult for Le Fort III. We developed the transmaxillary sinus approach (TSA) for the Le Fort II osteotomy that cuts the posterior wall of the MS directly. This report illustrates this easy-to-use procedure for the Le Fort II osteotomy in syndromic craniosynostosis. This procedure was performed in an 18-year-old patient with Apert syndrome and a 15-year-old patient with Pfeiffer syndrome. The thin anterior walls of the MS were removed through an intraoral approach to look inside the MS. Then, the posterior walls were cut by chisel under direct vision using light. The other osteotomy was performed as usual. Distraction osteogenesis with internal and external devices was used in combination. The advantages of TSA are the direct posterior wall osteotomy of the MS with no down fracture and minimal invasiveness to the mucosa of the MS under direct vision. However, the disadvantage is that TSA becomes a blind procedure in a case with no MS or hypoplasia. We developed the TSA for the Le Fort II osteotomy, which could provide direct observation and perform the posterior wall osteotomy of the MS without down fracture. We believe that TSA is an effective surgical procedure for the Le Fort II osteotomy.

  18. Three-dimensional Nasolabial Morphologic Alterations Following Le Fort I

    PubMed Central

    DeSesa, Christopher R.; Metzler, Philip; Sawh-Martinez, Rajendra

    2016-01-01

    Background: Le Fort I osteotomy imparts significant changes to the nasolabial region. Past studies have relied on 2-dimensional data and have not delineated differences among various Le Fort I subtypes. The purpose of this study is to 3-dimensionally analyze Le Fort I–induced nasal and lip changes comparing advancement alone versus widening alone [surgically assisted maxillary expansion (SAME)] versus advancement and widening. We hypothesize that the combination of maxillary advancement with widening will result in the most profound changes. Methods: A retrospective cohort study was performed. Included Le Fort I patients were grouped as: (1) nonsegmental straight advancement, (2) widening without advancement, and (3) segmental advancement and widening. Pre- and postoperative 3-dimensional photogrammetry (Canfield) were analyzed. Anthropometric landmarks were placed and measured by 2 independent observers. Statistics involved both paired and unpaired t tests (significance = P < 0.05). Results: One hundred eight photogrammetric data sets were analyzed, including 46 single-piece, 26 SAME, and 36 segmental. Significant postoperative nasal changes were observed within each intragroup analysis. The most dramatic changes were seen after segmental Le Fort I with advancement and widening, which included alar base width, alar width, nostril width, and soft triangle angle, all P < 0.05. Conclusions: Le Fort I osteotomy results in significant alteration of the nasolabial morphology. This is the first study to 3-dimensionally analyze nasal changes that occur comparing maxillary advancement alone versus widening alone (SAME) versus advancement with widening. These objective data permit improved patient counseling and surgical planning. PMID:27622116

  19. Transmaxillary Sinus Approach for Le Fort II Osteotomy

    PubMed Central

    Fukawa, Toshihiko; Hirakawa, Takashi; Satake, Toshihiko; Maegawa, Jiro

    2016-01-01

    Summary: The Le Fort II osteotomy is a relatively rare operation. The posterior wall osteotomy of the maxillary sinus (MS) is often difficult for Le Fort III. We developed the transmaxillary sinus approach (TSA) for the Le Fort II osteotomy that cuts the posterior wall of the MS directly. This report illustrates this easy-to-use procedure for the Le Fort II osteotomy in syndromic craniosynostosis. This procedure was performed in an 18-year-old patient with Apert syndrome and a 15-year-old patient with Pfeiffer syndrome. The thin anterior walls of the MS were removed through an intraoral approach to look inside the MS. Then, the posterior walls were cut by chisel under direct vision using light. The other osteotomy was performed as usual. Distraction osteogenesis with internal and external devices was used in combination. The advantages of TSA are the direct posterior wall osteotomy of the MS with no down fracture and minimal invasiveness to the mucosa of the MS under direct vision. However, the disadvantage is that TSA becomes a blind procedure in a case with no MS or hypoplasia. We developed the TSA for the Le Fort II osteotomy, which could provide direct observation and perform the posterior wall osteotomy of the MS without down fracture. We believe that TSA is an effective surgical procedure for the Le Fort II osteotomy. PMID:27014548

  20. Searching the animal psyche with Charles Le Brun.

    PubMed

    Cohen, Sarah R

    2010-07-01

    Around 1670 the French court painter and Academician Charles Le Brun produced a series of drawings featuring naturalistic animal heads, as well as imaginary heads in which he refashioned various nonhuman animal species to make humanoid physiognomies. What were the purpose and significance of these unusual works? I argue that they show Le Brun's interest in what we today would call animal psychology: focusing upon the sensory organs and their connections with the animal's brain, Le Brun studied his animals as conscious protagonists of the natural realm. One source that may have served him in this project was Marin Cureau de La Chambre's De la Connoissance des bestes of 1645, in which the physician argued that animals possess a conscious soul grounded in the senses. However, Le Brun's animal-humans have no clear place in the artist's taxonomy--nor, indeed, in any seventeenth-century understandings of species. It is rather John Locke, at his most skeptical, who offers the best parallel in the realm of natural philosophy to Le Brun's unsettling animal-humans. Probably without meaning to, Le Brun demonstrated through his eerie, boundary-crossing creatures the limits of visual classification.

  1. Three-dimensional Nasolabial Morphologic Alterations Following Le Fort I

    PubMed Central

    DeSesa, Christopher R.; Metzler, Philip; Sawh-Martinez, Rajendra

    2016-01-01

    Background: Le Fort I osteotomy imparts significant changes to the nasolabial region. Past studies have relied on 2-dimensional data and have not delineated differences among various Le Fort I subtypes. The purpose of this study is to 3-dimensionally analyze Le Fort I–induced nasal and lip changes comparing advancement alone versus widening alone [surgically assisted maxillary expansion (SAME)] versus advancement and widening. We hypothesize that the combination of maxillary advancement with widening will result in the most profound changes. Methods: A retrospective cohort study was performed. Included Le Fort I patients were grouped as: (1) nonsegmental straight advancement, (2) widening without advancement, and (3) segmental advancement and widening. Pre- and postoperative 3-dimensional photogrammetry (Canfield) were analyzed. Anthropometric landmarks were placed and measured by 2 independent observers. Statistics involved both paired and unpaired t tests (significance = P < 0.05). Results: One hundred eight photogrammetric data sets were analyzed, including 46 single-piece, 26 SAME, and 36 segmental. Significant postoperative nasal changes were observed within each intragroup analysis. The most dramatic changes were seen after segmental Le Fort I with advancement and widening, which included alar base width, alar width, nostril width, and soft triangle angle, all P < 0.05. Conclusions: Le Fort I osteotomy results in significant alteration of the nasolabial morphology. This is the first study to 3-dimensionally analyze nasal changes that occur comparing maxillary advancement alone versus widening alone (SAME) versus advancement with widening. These objective data permit improved patient counseling and surgical planning.

  2. Ultrastructural localization of glycodelin oligosaccharides Le-x and Le-y in human seminal vesicles by immunogold staining

    PubMed Central

    Piludu, M; Cossu, M; De Lisa, A; Piras, M; Lantini, M S

    2007-01-01

    Histo-blood group antigens Le-x and Le-y are oligosaccharidic terminals that characterize many glycoproteins in the human tissues. In seminal plasma, they are expressed as part of the so-called glycodelin S, which is suggested to regulate sperm capacitation/decapacitation. It has recently been demonstrated that the core protein of glycodelin S is secreted by seminal vesicles. Here we show that epithelial cells of human seminal vesicles also release the Le-x and Le-y antigens. The presence of these substances in secretory material was revealed by means of an immunogold staining method in normal surgical samples. The results suggest that glycodelin S is secreted by seminal vesicles in its finished glycosylated form. Moreover, antigen reactivity was also revealed associated with plasma membranes. PMID:17331183

  3. Le Point sur la Pharmacologie des Agents Anesthesiques Chez le Brule Grave

    PubMed Central

    Siah, S.; Ababou, K.; Benziane, H.; El Jaoudi; Bensghir, M.; Bakali, H.; El Wali, A.; Ihrai, I.; Drissi, N.K.

    2008-01-01

    Summary La pharmacologie des agents anesthésiques chez le brûlé est variable et imprévisible. Dans les premières 48 h, il y a une hypovolémie avec chute du débit cardiaque et des fuites plasmatiques. Après 48 h, il y a une hypervolémie avec augmentation du débit cardiaque, hypermétabolisme et la clearance des médicaments est augmentée. Parmi les facteurs de déséquilibre, on retrouve les variations des protéines plasmatiques. Deux protéines sont importantes chez le brûlé grave : l'albumine et l'alpha 1- glycoprotéine. Leur taux varie beaucoup au cours de l'évolution de la brûlure. Les agents anesthésiques dont la liaison avec ces deux protéines est prédominante verront leur pharmacocinétique modifiée. L'anesthésiste-réanimateur du service des brûlés va maîtriser ces notions pharmacologiques pour utiliser à bon escient les agents anesthésiques. PMID:21991108

  4. Transitions de phase dans le oxyde de yttrium vanadium

    NASA Astrophysics Data System (ADS)

    Roberge, Benoit

    Dans le mémoire qui suit, les ordres structural, magnétiques et orbital dans le YVO3 sont étudiés avec l'aide de la diffraction des rayons X,de la spectroscopie Raman et de la technique de la cavité résonnante hyperfréquence. L'objectif premier consiste à observer l'évolution de ces ordres en fonction de la température. Le mémoire met ensuite en évidence le couplage entre les différents ordres cohabitants dans le YVO3 . Les mesures effectuées par la diffraction des rayons X permettent de mesurer le caractère polycrystallin des échantillons du YVO 3. Une comparaison de nos mesures avec des mesures de diffraction des rayons X faites sur la poudre de YVO3 indique la faible présence de maclage. Les mesures effectuées avec la technique de résonnance hyperfréquence permettent de suivre l'évolution de la constante diélectrique en fonction de la température. Les changements impliquant l'ordre orbital se manifestent de manière évidente dans la constante diélectrique à 200 K et à 77 K. La transition diélectrique détectée à 77 K est une transition de premier ordre. Un couplage entre les propriétés diélectriques et magnétiques est observable à la température de Néel à 114 K. L'effet d'un champ magnétique fixe sur la température de transition de l'ordre orbital survenant à 77 K est également remarquable. Cela indique un couplage magnétodiélectrique démontrant ainsi le caractère multiferroïque du YVO 3. Finalement, l'observation d'un mécanisme de relaxation pouvant être modélisé par le modèle d'Havriliak-Negami est observé en dessous de 77 K. En utilisant le modèle d'Arrhénius et le modèle d'Havriliak-Negami, on peut caractériser le mécanisme avec son énergie d'activation et son temps de relaxation. Les mesures effectuées en spectroscopie Raman permettent de suivre l'évolution de la structure du YVO3 en fonction de la température. Les deux changements structuraux survenant à 200 K et 77 K sont observés. Le

  5. Additional orthognathic surgery following Le Fort III and monobloc advancement.

    PubMed

    Nout, E; Koudstaal, M J; Wolvius, E B; Van der Wal, K G H

    2011-07-01

    Severe midface hypoplasia in patients with various craniofacial anomalies can be corrected with Le Fort III or monobloc advancement. Often additional corrective orthognathic surgery is indicated to achieve Class I occlusion and a normal inter-jaw relationship. This study evaluated the incidence of, and the surgical indications for, secondary orthognathic surgery following Le Fort III/monobloc advancement. The total study group consisted of 41 patients: 36 patients with Le Fort III advancement and 5 patients with monobloc advancement. Seven patients underwent additional orthognathic surgery. Of the resulting 18 non-operated patients older than 18 years at the end of follow-up, Class I occlusion was observed in 11 patients. In the remaining patients malocclusions were dentally compensated with orthodontic treatment. None of the patients was scheduled for additional orthognathic surgery due to the absence of functional complaints and/or resistance to additional surgery. Le Fort III and monobloc advancement aim to correct skeletal deformities on the level of zygoma, orbits, nasal area and forehead, but Class I occlusion is frequently not achieved. Additional orthognathic surgery is often indicated in patients undergoing Le Fort III or monobloc advancement. Naso-endoscopic analysis of the upper airway and the outcomes of sleep studies may influence the orthognathic treatment plan.

  6. Trigeminocardiac reflex and haemodynamic changes during Le Fort I osteotomy.

    PubMed

    Kiani, M T; Tajik, G; Ajami, M; Fazli, H; Kharazifard, M J; Mesgarzadeh, A

    2016-05-01

    The Le Fort I osteotomy is performed under general anaesthesia and specific haemodynamic conditions, i.e. hypotensive general anaesthesia. This study assessed the incidence of the trigeminocardiac reflex (TCR) during the different stages of the Le Fort I osteotomy. Forty-seven patients requiring a Le Fort I osteotomy were included. General anaesthesia was induced. In terms of haemodynamic changes, each patient's oxygen saturation (SpO2), mean arterial pressure (MAP), heart rate (HR), and electrocardiogram (ECG) were monitored by SADAAT Monitoring System and recorded during the different stages of osteotomy: before the induction of anaesthesia, before osteotomy cuts, after finishing the right pterygoid plate osteotomy, after finishing the left pterygoid plate osteotomy, and after performing down-fracture of the maxilla. No significant alteration in haemodynamic values was seen at the different stages of Le Fort I osteotomy. One patient showed arrhythmia with non-sinus junction rhythm after sinus bradycardia and two premature atrial contractions in the down-fracture stage, which led to the abrupt cessation of the procedure by the surgeon. This study showed no significant alterations in haemodynamic values during the different stages of Le Fort I osteotomy. Halting the procedure momentarily was sufficient to allow spontaneous normalization of the HR, blood pressure, and dysrhythmia.

  7. Le zona ophtalmique: une dermatose rare chez l'enfant

    PubMed Central

    Zakia, Douhi; Meziane, Marieme; Salim, Gallouj; Zahra, Mernissi Fatima

    2015-01-01

    Le zona est dû a une réactivation du virus varicelle-zona (VZV) qui reste quiescent dans les ganglions sensitifs dorsaux après la varicelle. Le zona de l'enfant est rare et particulièrement la forme ophtalmique, qui peut être responsable de complications oculaires graves nécessitant une prise en charge adéquate et précoce. Il est parfois associé à des douleurs post-zostériennes dont le traitement est difficile. L'aciclovir per os administré dans les 72 heures après l’éruption a prouvé son efficacité dans la prévention des complications oculaires. Nous en rapportant un nouveaux cas chez un garçon immunocompétent de 9 ans, sans notion de varicelle antérieure. PMID:26955408

  8. Le fort I maxillary advancement using distraction osteogenesis.

    PubMed

    Combs, Patrick D; Harshbarger, Raymond J

    2014-11-01

    Treatment of maxillary hypoplasia has traditionally involved conventional Le Fort I osteotomies and advancement. Advancements of greater than 10 mm risk significant relapse. This risk is greater in the cleft lip and palate population, whose anatomy and soft tissue scarring from prior procedures contributes to instability of conventional maxillary advancement. Le Fort I advancement with distraction osteogenesis has emerged as viable, stable treatment modality correction of severe maxillary hypoplasia in cleft, syndromic, and noncleft patients. In this article, the authors provide a review of current data and recommendations concerning Le Fort I advancement with distraction osteogenesis. In addition, they outline their technique for treating severe maxillary hypoplasia with distraction osteogenesis using internal devices.

  9. Le syndrome des enfants battus: aspects cliniques et radiologiques

    PubMed Central

    Jlalia, Zied; Znaigui, Talel; Smida, Mahmoud

    2016-01-01

    La maltraitance physique des enfants ou le syndrome des enfants battus est responsable de plus de 75.000 décès par an en France. Ce problème de santé publique reste sous diagnostiqué en Tunisie et dans le monde. Le chemin a été laborieux pour la reconnaissance du syndrome des enfants battus dans certaines sociétés même occidentales. Nous avons voulus exposer ce problème aux praticiens afin qu'il soit mieux diagnostiqué et pris en charge. La maltraitance physique des enfants est appelée à tort syndrome de Silverman qui ne regroupe en fait que les lésions squelettiques chez ces enfants tels que les fractures. Mots clés: Fracture, maltraitance, enfant, neuro-radiologie PMID:27642408

  10. Le lipome para testiculaire: à propos d'un cas rare

    PubMed Central

    Lasri, Abdelouahed; Lamchahab, Hamza; Lahyani, Mounir; Karmouni, Tarik; Elkhader, Khalid; Koutani, Abdellatif; Andaloussi, Ahmed Ibn Attya

    2015-01-01

    Les tumeurs para testiculaires sont des tumeurs rares et complexes qui ont une symptomatologie insidieuse et pauvre. Les formes bénignes représentent 70%. Le lipome para testiculaire étant le type le plus fréquent. L'examen clinique est peu spécifique. L'examen échographique est la pierre angulaire pour assoir le diagnostic. Le traitement chirurgical s'impose en cas de tumeur symptomatique, l'histologie étant habituellement typique permet la confirmation diagnostique. Le pronostic est bon malgré d’éventuelles récidives. PMID:26175802

  11. Le lymphome primitif de la vessie: un cas clinique

    PubMed Central

    Statoua, Mouad; Mokrim, Maha; El Ghanmi, Jihad; Karmouni, Tariq; El Khadir, Khalid; Koutani, Abdellatif; Attya, Ahmed Iben; Errihani, Hassan

    2014-01-01

    Les tumeurs de vessie constituent les tumeurs les plus fréquentes de l'appareil uro-génital chez l'homme, le type histologique est dominé par le carcinome urothéliale, la localisation primitive du lymphome malin est extrêmement rare et constitue souvent une surprise diagnostique quand elle est retrouvée. Nous rapportons à travers cette observation le cas d'un patient pris en charge au sein de notre formation qui a bénéficié, suite a un bilan d'hématurie objectivant une formation bourgeonnante intra vésicale a l’échographie abdominale, d'une résection transurétrale de la vessie d'un polype géant dont les résultats anapathologies sont revenus en faveur d'un lymphome primitif de la vessie, le patient a bénéficié d'une chimiothérapie adjuvante a base de RCHOP, les suites étaient simples et une surveillance cystoscopique et scannographique n'a pas objectivé de récidive avec un recul de 18 mois. Le lymphome primitif de la vessie est une entité rare, sa chimio sensibilité fait de ce type de tumeur une maladie curable, le diagnostic est histologique et vu la rareté de l'affection aucun consensus n'est standardisé. PMID:25419286

  12. Decolonizing the Choctaws: Teaching LeAnne Howe's "Shell Shaker"

    ERIC Educational Resources Information Center

    Hollrah, Patrice

    2004-01-01

    "Shell Shaker" (2001) by LeAnne Howe (Choctaw) is a novel that gives students an opportunity to learn that the history and culture of the Choctaw Nation of Oklahoma are alive today. Winner of the Before Columbus Foundation American Book Award in 2002, the novel deals with two parallel stories that converge in the present, one about the eighteenth…

  13. MoLeNET Mobile Learning Conference 2009: Research Papers

    ERIC Educational Resources Information Center

    Guy Parker, Ed.

    2010-01-01

    The Mobile Learning Network (MoLeNET) is a unique collaborative approach to encouraging, supporting, expanding and promoting mobile learning, primarily in English post-14 education and training, via supported shared cost mobile learning projects. Collaboration at national level involves participating institutions and the Learning and Skills…

  14. Nasal profile changes with le fort I maxillary advancement surgery.

    PubMed

    Marşan, Gülnaz; Hocaoğlu, Emre; Cura, Nil; Emekli, Ufuk

    2015-03-01

    Introduction : The purpose of this study was to quantify anteroposterior facial soft tissue changes with respect to underlying skeletal movements after Le Fort I maxillary advancement surgery by using lateral cephalograms taken before and after the operation. Materials and Methods : The study group consisted of 20 patients (10 women, 10 men; mean age 23.4 ± 1.4 years) having a Class III skeletal deformity caused by a retrognathic maxilla. All patients were treated by Le Fort I maxillary advancement osteotomy. Lateral cephalograms were taken before and 1.6 ± 0.4 years after surgery. Results : The anteroposterior position of A-point and anteroposterior position of maxillary incisor were significantly protracted (-2.69 ± 3.34 and -2.68 ± 3.21, respectively; P < .01). The nasal anteroposterior and superoinferior positions (NASALAP and NASALSI, respectively) were significantly changed (-2.70 ± 6.81, P < .01, and -2.55 ± 5.80, P < .05, respectively) and nasal elevation and protraction were observed after Le Fort I maxillary advancement surgery. Conclusions : The changes in anteroposterior and superoinferior positions of A-point were correlated with the nasal superoinferior position (r = -0.71 , P < .05; r = 0.72, P < .05) after Le Fort I maxillary advancement surgery.

  15. Expectation of "Le Petit Prince"'s home

    NASA Astrophysics Data System (ADS)

    Abe, Masanao; Ohba, Yohei; Ishiguro, Masateru; Hasegawa, Sunao; Fuse, Tetsuharu

    2002-11-01

    We observed a few hundred meter-sized asteroid like "Le Petit Prince"'s home using Subaru telescope. The name of the asteroid is 1998 SF36, which is a target object of the Japanese asteroid sample return mission, MUSES-C. We report the results of the observations and expect the true picture of the tiny-sized asteroid.

  16. LeRC in-house experimental research

    NASA Technical Reports Server (NTRS)

    Lyons, Valerie J.

    1992-01-01

    The topics covered include the following: LeRC in-house experimental research; combustion concepts; schedule for in-house experiments; lean premixed prevaporized combustion; comparisons of low NO(x) lean premixed/prevaporized data; rich burn/quick quench/lean burn (RQL); RQL combustion; fuel rich catalytic combustion; advanced diagnostics; and ceramic matrix liner test rig.

  17. Le Dernier Cartoucherie: Refuge and the Performance of Care

    ERIC Educational Resources Information Center

    Fisek, Emine

    2008-01-01

    In 2003, the Paris-based theatre company Theatre du Soleil launched "Le Dernier Caravanserail: Odyssees", a collaborative creation based on stories that company members had collected from refugees at the Sangatte refugee camp outside Calais, among other locations. Scenes of moral reasoning dotted the six-hour spectacle, calling to mind the…

  18. LHC, le Big Bang en éprouvette

    ScienceCinema

    None

    2016-07-12

    Notre compréhension de l’Univers est en train de changer… Bar des Sciences - Tout public Débat modéré par Marie-Odile Montchicourt, journaliste de France Info. Evenement en vidéoconférence entre le Globe de la science et de l’innovation, le bar le Baloard de Montpellier et la Maison des Métallos à Paris. Intervenants au CERN : Philippe Charpentier et Daniel Froideveaux, physiciens au CERN. Intervenants à Paris : Vincent Bontemps, philosophe et chercheur au CEA ; Jacques Arnould, philosophe, historien des sciences et théologien, Jean-Jacques Beineix, réalisateur, producteur, scénariste de cinéma. Intervenants à Montpellier (LPTA) : André Neveu, physicien théoricien et directeur de recherche au CNRS ; Gilbert Moultaka, physicien théoricien et chargé de recherche au CNRS. Partenariat : CERN, CEA, IN2P3, Université MPL2 (LPTA) Dans le cadre de la Fête de la science 2008

  19. Some special features of the le chatelier-braun principle

    NASA Astrophysics Data System (ADS)

    Nesis, E. I.; Skibin, Yu. N.

    2000-07-01

    The relaxation reaction of a system that follows from the Le Chatelier-Braun principle and weakens the result of an external influence turns out to be more intense under a complex action. A method for quantitative determination of the weakening effect for simple and complex actions is suggested.

  20. Le Chatelier's Principle Applied to the Temperature Dependence of Solubility.

    ERIC Educational Resources Information Center

    Treptow, Richard S.

    1984-01-01

    One effect of temperature is its influence on solubility, and that effect is used as a common example when teaching Le Chatelier's principle. Attempts to clarify the question of whether the principle holds in the case of the solubility of ionic compounds in water by investigating the literature data in detail. (JN)

  1. Restorative Justice Scripts in Ursula K. Le Guin's "Voices"

    ERIC Educational Resources Information Center

    Oziewicz, Marek C.

    2011-01-01

    This essay examines restorative justice scripting in "Voices", the second volume of Ursula K. Le Guin's "Annals of the Western Shore." Narrated by a rape-child, "Voices" is the story of an occupied city-state and of how the conquered and the conquerors negotiate a formula for peaceful coexistence. They are able to do so by enacting a restorative…

  2. LePera Career Activity Program. Final Report.

    ERIC Educational Resources Information Center

    Truby, Max E.

    The purpose of the research project was to determine the effectiveness of a comprehensive career orientation program in increasing awareness of self and of career opportunities in students of rural areas. Conducted with grades 7 and 8 in LePera school in Parker, Arizona from May 1973 to October 1974, the program provided occupational information…

  3. Computer Assisted Instruction: The Game "Le Choc des Multinationales."

    ERIC Educational Resources Information Center

    Cramer, Hazel

    "Le Choc de Multinationales" is a microcomputer game for students in an upper-level commercial French couse, to be played by two opponents, one of whom may be another student or the computer itself as a direct business competitor. The game's requirements for language use and knowledge of business and economics theory and principles are moderate,…

  4. Les enfants et le theatre (Children and the Theater).

    ERIC Educational Resources Information Center

    Ferrari, Josephine

    1980-01-01

    Describes a project involving the presentation of "Le petit prince" as an exercise in dramatics by children in a French-Italian bilingual education class. Two steps in the process are discussed: (1) the study of the text, and (2) the activities involved in getting the play ready for performance. (AMH)

  5. Le Chatelier's Principle and the Prediction Temperature on Solubilities.

    ERIC Educational Resources Information Center

    Fernandez-Prini, R.

    1982-01-01

    Discusses Le Chatelier's Principle from a thermodynamic perspective and applies it to the effect of temperature on the solubility of gases in liquids. Rationale of this discussion is to evaluate data in a previous article claimed to be contradictory to the Principle. (Author/JN)

  6. Le syndrome d'embolie graisseuse post traumatique

    PubMed Central

    Berdai, Adnane Mohamed; Shimi, Abdelkarim; Khatouf, Mohammed

    2014-01-01

    Le syndrome d'embolie graisseuse est une complication grave des fractures des os longs, il est la conséquence de la dissémination des particules graisseuses dans la microcirculation. L'objectif de ce travail est de déterminer le profil épidémiologique, la présentation clinique et paraclinique de ce syndrome et sa prise en charge thérapeutique. Notre étude porte sur 11 cas de syndrome d'embolie graisseuse colligés au service de réanimation A1 au centre hospitalier universitaire Hassan II de Fès, de Janvier 2009 à Juin 2012. Le diagnostic positif est basé sur les critères de Gurd. Les cas collectés se caractérisent par la prédominance du sexe masculin, d'un âge inférieur à 40 ans, présentant une fracture fémorale. Ce syndrome survient souvent dans les 72 heures après le traumatisme. La présentation clinique est dominée par l'hypoxémie et les troubles de conscience. Sur le plan biologique: l'anémie et la thrombopénie sont les manifestations les plus fréquentes. La prise en charge est symptomatique, 63% des patients ont nécessité l'intubation et la ventilation. L’évolution n'est pas toujours bénigne. Nos résultats confirme le polymorphisme de la présentation clinique et paraclinique du syndrome d'embolie graisseuse. Le diagnostic de ce syndrome se base sur des critères cliniques, mais reste essentiellement un diagnostic d’élimination. La prise en charge est symptomatique. La prévention de ce syndrome est essentielle et se base sur une fixation précoce des fractures des os longs. PMID:25452829

  7. The Use of Brainlab Navigation in Le Fort III Osteotomy.

    PubMed

    Wood, Jeyhan S; Purzycki, Adam; Thompson, Jim; David, Lisa R; Argenta, Louis C

    2015-05-01

    Le Fort III osteotomy is commonly used in the surgical correction of midface hypoplasia, specifically in patients with syndromic craniosynostosis. These osteotomies can be associated with significant complications, which are often the result of incomplete or inaccurate osteotomies. Brainlab, a technology first developed for neurosurgery, has been applied to numerous surgical subspecialties. The aim of this study was to report our initial experience using the Brainlab VectorVision2 and Brainlab Curve (Brainlab, Westchester, IL) as an intraoperative guidance system for osteotomy placement during Le Fort III advancement. Three pediatric patients with syndromic craniosynostosis and midface hypoplasia scheduled to undergo Le Fort III advancement were scanned preoperatively with 0.6-mm computed tomography cuts, which were then uploaded to the Brainlab system. All surgeries commenced with rigid fixation of the Brainlab registration device to the patient's skull. The navigation system was used intraoperatively to accurately determine osteotomy sites and trajectories. External distractors were placed without complication. Mean length of surgery was 331 minutes, and mean estimated blood loss was 500 mL. No transfusion was required with a mean postoperative hemoglobin of 8.3 g/dL. The application of Brainlab technology to Le Fort III advancement proved useful in establishing precise osteotomy lines and trajectories. Looking forward, this technology could be applied to a minimal dissection technique in order to avoid extensive blood loss. Further study would be needed to determine possible benefits such as reduced complications or operative time when using an intraoperative navigation system for image-guided osteotomy placement during Le Fort III advancement.

  8. Connecting Instructional and Cognitive Aspects of an LE: A Study of the Global Seminar Project

    ERIC Educational Resources Information Center

    Savelyeva, Tamara

    2012-01-01

    My research problem is based on the lack of unifying conceptual cohesion between the discourses concerning cognitive and instructional aspects of learning environments (LE). I contrast that lack with practical developments of LE studies connected at the level of practical implementation and evaluation. Next, I briefly review the LE boundaries,…

  9. The NextGen Model Atmosphere Grid for 3000{le}T{sub eff}{le}10,000 K

    SciTech Connect

    Hauschildt, P.H.; Allard, F.; Baron, E.

    1999-02-01

    We present our NextGen Model Atmosphere grid for low-mass stars for effective temperatures larger than 3000 K. These LTE models are calculated with the same basic model assumptions and input physics as the VLMS part of the NextGen grid so that the complete grid can be used, e.g., for consistent stellar evolution calculations and for internally consistent analysis of cool star spectra. This grid is also the starting point for a large grid of detailed NLTE model atmospheres for dwarfs and giants. The models were calculated from 3000 to 10,000 K (in steps of 200 K) for 3.5{le}logthinspg{le}5.5 (in steps of 0.5) and metallicities of {minus}4.0{le}[M/H]{le}0.0. We discuss the results of the model calculations and compare our results to the Kurucz grid. Some comparisons to standard stars like Vega and the Sun are presented and compared with detailed NLTE calculations. {copyright} {ital {copyright} 1999.} {ital The American Astronomical Society}

  10. Fruit quality of transgenic tomatoes with suppressed expression of LeETR1 and LeETR2 genes.

    PubMed

    Bao, Bili; Ke, Leqin; Jiang, Jianmei; Ying, Tiejin

    2007-01-01

    Tomato fruit is renowned for its high concentration of phyto-nutrients such as lycopene and carotenoids, overall contribution to nutrition and human health. The effect of antisense suppression of ethylene receptor genes LeETR1 and LeETR2 over the quality of tomato fruit was investigated in this paper. During the different stages of ripening, the fruit of antisense transgenic tomatoes of ale1 and ale2, compared to their wild type B1, showed higher total soluble solids, acidity and electrolytes accumulations and color development; lower fruit firmness, fruit viscosity and fruit elasticity. However, no significant difference of Vc content, total sugar, fruit pH value and fruit pigments between transgenic lines and B1 were noticed. ale1 and ale2 showed shortened shelf life. The data suggest that fruit with suppressed LeETR1 and LeETR2 genes expression have stronger ethylene response, which accelerate fruit ripening and greatly altered tomato variety characteristics.

  11. DentLE. The Dental Learning Environment: a prototype demonstration.

    PubMed Central

    Vullo, R. P.; Eisner, J.

    1992-01-01

    DentLE, the Dental Learning Environment is a hypermedia software system being prototyped as part of a research and development project at the State University of New York at Buffalo School of Dental Medicine. The design seeks to reach beyond single discipline software or cases, and integrate a range of patient problems within a comprehensive dental knowledge base. The approach is to use computer and hypermedia technology to weave together the disciplines of dentistry so that learning occurs in relation to patients, as they appear in the real world. The DentLE system prototype allows the learner to explore information in all the disciplines related to patient problems, as well as other information including "blind alleys" and results of curiosity. PMID:1482989

  12. Sequence diversity and enzyme activity of ferric-chelate reductase LeFRO1 in tomato.

    PubMed

    Kong, Danyu; Chen, Chunlin; Wu, Huilan; Li, Ye; Li, Junming; Ling, Hong-Qing

    2013-11-20

    Ferric-chelate reductase which functions in the reduction of ferric to ferrous iron on root surface is a critical protein for iron homeostasis in strategy I plants. LeFRO1 is a major ferric-chelate reductase involved in iron uptake in tomato. To identify the natural variations of LeFRO1 and to assess their effect on the ferric-chelate reductase activity, we cloned the coding sequences of LeFRO1 from 16 tomato varieties collected from different regions, and detected three types of LeFRO1 (LeFRO1(MM), LeFRO1(Ailsa) and LeFRO1(Monita)) with five amino acid variations at the positions 21, 24, 112, 195 and 582. Enzyme activity assay revealed that the three types of LeFRO1 possessed different ferric-chelate reductase activity (LeFRO1(Ailsa) > LeFRO1(MM) > LeFRO1(Monita)). The 112th amino acid residue Ala of LeFRO1 is critical for maintaining the high activity of ferric-chelate reductase, because modification of this amino acid resulted in a significant reduction of enzyme activity. Further, we showed that the combination of the amino acid residue Ile at the site 24 with Lys at the site 582 played a positive role in the enzyme activity of LeFRO1. In conclusion, the findings are helpful to understand the natural adaptation mechanisms of plants to iron-limiting stress, and may provide new knowledge to select and manipulate LeFRO1 for improving the iron deficiency tolerance in tomato.

  13. LeCroy MQT300A - charge to time converter

    SciTech Connect

    Yamrone, B.; Roberts, K.; Kelly, J.

    1997-12-31

    The MQT300A was developed to offer high resolution (12 bit) and wide dynamic range (18 bit) with reasonable cost, high density and fast conversion time (< 10 {mu}s). The reduced conversion time has allowed its first users the option to choose whether or not to develop a fast clear strategy as part of their trigger system. It can also be used for chamber-mounted applications allowing compact digital data cabling to the remote TDC. The MQT300A is a custom development produced in collaboration with the BELLE collaboration at KEK and the CLEO group at Cornell. In this collaboration Cornell and KEK were partners with LeCroy in both the specification and evaluation of the first prototypes. LeCroy has been responsible for the remainder of the project. The MQT300A is available in LeCroy modules and also as a separate monolithic. The MQT300A was designed to take advantage of the latest generation of multi-hit TDCs, for example the LeCroy 1877S FASTBUS ADC. The 1877S was specifically optimized to improve conversion time and to intelligently minimize the data record size for the MQT300A application. A prototype part was designed and fabricated using a custom bipolar process. Though fully functional it did not meet several important performance specifications. A reiteration with significant redesign of two sections resulted in a part that meets all specifications. The unique encoding algorithm used to provide auto-ranging has had a U.S. patent allowed. The part is now commercially available in production volumes.

  14. LeChâtelier's Principle in the Sciences

    NASA Astrophysics Data System (ADS)

    Thomsen, Volker B. E.

    2000-02-01

    LeChâtelier's principle of chemical equilibrium is actually a very general statement about systems in equilibrium and their behavior when subjected to external force or stress. Although one almost never finds mention of his name or law in other sciences, analogous principles and concepts do exist. In this note we examine some of the similar forms taken by this chemical principle in the fields of physics, geology, biology, and economics. Lenz's law in physics is an example of electromagnetic equilibrium and the geological principle of isostatic uplift concerns mechanical equilibrium. Both are strictly consequences of conservation of energy. LeChâtelier's principle deals with thermodynamic equilibrium and involves both the first and second laws of thermodynamics. The concept of homeostasis in biology and the economic law of supply and demand are both equilibrium-like principles, but involve systems in the steady state. However, all these principles involve the stability of the system under consideration and the analogies presented may be useful in the teaching of LeChâtelier's principle.

  15. [A new technic for LE cell formation. Preliminary report].

    PubMed

    Gómez-Estrada, H; Fernández-Quintero, P; Toro-Pérez, A; Arellando-Blanco, J; Ochoa Díaz-López, H; Tapia-Arizmendi, G

    1976-01-01

    In special designed vials using coverslides glued to segments of polyethilene test tubes of 0.15 ml of fibrin free blood were incubated during 45 min to 37 degrees C in a humid chamber. Blood samples were obtained from patients with disseminated Lupus erythematosus (DLE) and normal subjects (N). Adhered polymorpho-nuclear cells (PNC) to glass were washed with Hank's solution; immediately 0.15 ml of DLE or N serum containing 5X10(6) lymphocytes (L) were added to culture cells and incubated at 37 degrees C during 30 min. Lymphocytes were previously incubated at 37 degrees C during 30 min with either N serum or DLE serum. Thereafter the segment of polyethilene test tube was detached from coverslides and cells attached to glass was washed with Hank's solution and stained with Wright solution. PMN of DLE and N in presence of L of DLE and N incubated with fresh serum of DLE formed 5 to 15% of LE cells. Determining factor for LE cells formation is the serum of DLE. Slides contained only PMN and LE cells which make easy the observation of results. All possible combinations with PMN and DLE serum and N serum allowed inclusion of several negative or positive control groups.

  16. Mandibular growth following Le Fort I osteotomy in adolescent monkeys.

    PubMed

    Nanda, R; Bouayad, O; Topazian, R G

    1987-06-01

    Le Fort I osteotomy with anterior and superior repositioning of the maxilla was performed on adolescent Macaca fascicularis monkeys to study its effect on the subsequent growth and remodeling changes of the mandible. Six adolescent Macaca fascicularis monkeys were randomly divided into two surgical groups and eight others served as controls. Group I animals underwent a Le Fort I advancement and Group II animals experienced a Le Fort I advancement and impaction. All monkeys received tantalum implants in the anterior part of the cranial base, on opposite sides of craniofacial sutures and in multiple sites of the maxilla and mandible. The immediate postsurgical occlusion of all experimental animals was a Class II molar relationship. The animals were followed for up to 12 months postoperatively. Analysis of cephalometric head films taken at monthly intervals showed that both the maxilla and the mandible of all experimental monkeys grew in a coordinated fashion, although the amount, rate, and direction of growth varied between control and experimental animals as well as between Group I and Group II animals. The largest increments and rates of growth were observed in the control animals, Group I animals, and Group II animals, respectively. This study indicates that the growth changes in both maxilla and mandible are related to the extent of injury caused by maxillary surgery. The results also showed that although the surgical procedures were performed in the maxilla, mandibular growth was significantly modulated by the surgically changed maxillary environment.

  17. Airborne pollen and spores of León (Spain)

    NASA Astrophysics Data System (ADS)

    Fernández-González, Delia; Suarez-Cervera, María; Díaz-González, Tomás; Valencia-Barrera, Rosa María

    1993-06-01

    A qualitative and quantitative analysis of airborne pollen and spores was carried out over 2 years (from September 1987 to August 1989) in the city of León. Slides were prepared daily using a volumetric pollen trap, which was placed on the Faculty of Veterinary Science building (University of León) 12m above ground-level. Fifty-one pollen types were observed; the most important of these were: Cupressaceae during the winter, Pinus and Quercus in spring, and Poaceae, Leguminosae and Chenopodiaceae in the summer. The results also showed the existence of a rich mould spore assemblage in the atmosphere. The group of Amerospores ( Penicillium, Aspergillus and Cladosporium) as well as Dictyospores ( Alternaria) were the most abundant; Puccinia was common in the air in August. Fluctuations in the total pollen and spores m3 of air were compared with meteorological parameters (temperature, relative humidity and rainfall). From the daily sampling of the atmosphere of León, considering the maximum and minimum temperature and duration of rainfall, the start of the pollen grain season was observed generally to coincide with a rise in temperature in the absence of rain.

  18. Le stéréorestituteur Kelsh

    USGS Publications Warehouse

    Kelsh, H.T.

    1949-01-01

    Le ste??re??orestituteur Kelsh est un appareil de restitution a?? double projection base?? sur le principe des anaglyphes, comme le Multiplex par exemple, mais il a une plus grande pre??cision que ce dernier, vu que les ne??gatifs sont utilise??s directement pour la restitution, sans que l'on soit oblige?? de les re??duire au pre??alable. Une telle solution devient possible lorsque l'e??chelle de l'image plastique (mode??le) est au moins 7 fois plus grande que celle des cliche??s. L'appareil comprend un support reposant par 4 pieds sur la table a?? dessin. Sa partie supe??rieure porte, par l'interme??diaire de trois vis calantes, un cadre dans lequel les deux chambres de projection sont suspendues. Des leviers de commande, agissant sur les chambres, permettent d'introduire la base, le de??versement et les inclinaisons transversale et longitudinale. Les cliche??s conjugue??s ou des diapositifs sont directement place??s dans les chambres de projection munies d'objectifs. En projetant les deux cliche??s au moyen de couleurs comple??mentaires, l'observateur - muni de lunettes a?? verres colore??s (couleurs comple??mentaires) - observe l'image plastique audessus de la table a?? dessin, l'orientation relative des chambres ayant e??te?? e??tablie au pre??alable. Pour le report des points de l'image plastique sur la minute, l'ope??rateur dispose d'une tablette amovible a?? marque-repe??re lumineuse qu'il de??place a?? la main et dont la hauteur au-dessus de la table a?? dessin peut e??tre commande??e par une molette. Pour e??tablir l'orientation absolue de l'image plastique, il suffit d'incliner convenablement le cadre de suspension a?? l'aide des vis calantes, l'orientation relative n'e??tant pas de??truite par cette ope??ration. Les deux cliche??s sont e??claire??s par des projecteurs munis d'une suspension a?? la cardan et relie??s a?? la tablette de restitution par des tiges te??lescopiques. Moyennant ce dispositif, l'e??clairage est concentre?? sur deux petites re

  19. Le médicament générique au Maroc: le point de vue du consommateur

    PubMed Central

    Zaoui, Sanaa; Hakkou, Farid; Filali, Houda; Khabal, Youssef; Tazi, Illias; Mahmal, Lahoucine

    2013-01-01

    Introduction Le médicament générique est souvent une origine de préjugés négatifs et de méfiance chez les professionnels de santé et les patients. Ceci pourrait être dû à plusieurs facteurs entre autre le manque des connaissances du patient sur ces médicaments. Le but de notre étude était d’évaluer l'information du consommateur sur les médicaments génériques et apprécier leur utilisation de ces médicaments. Méthodes Il s'agit d'une étude transversale réalisée de Janvier à Mars 2010 auprès de 251 sujets. Un questionnaire comprenant dix questions fermées a été utilisé. Les questions concernaient l’évaluation des connaissances sur les médicaments génériques, les sources d'information, le degré de confiance et d'information des patients sur ces médicaments. Une analyse descriptive simple des différentes variables a été réalisée. Résultats Dans notre étude, 126 sujets (50,2%) ont répondu connaître les médicaments génériques. Parmi eux, 52,3% les utilisaient et 67,4% estimaient qu'ils étaient insuffisamment informés sur ces médicaments. Les cadres supérieurs et les étudiants ont représenté la catégorie qui utilisait le plus les médicaments génériques (respectivement dans 40,9% et 25,7%) et qui était la mieux informée (respectivement dans 61,9% et 23,81%). Le faible coût a été la principale motivation d'utilisation du médicament générique (93,9%). Les médias ont représenté la première source d'information (59,5%). Après sensibilisation, 88,8% des sujets qui ne connaissaient pas le médicament générique ont été favorable à son utilisation. Conclusion Une promotion efficace par une politique d'information soutenue auprès des consommateurs et par des mesures incitatrices à la prescription et à la délivrance du générique par les médecins et les pharmaciens, pourront améliorer l'utilisation de ces médicaments dans notre pays. PMID:24009794

  20. Snow in Castile-León: trends and variability

    NASA Astrophysics Data System (ADS)

    Merino, A.; Campos, L.; López, L.; García-Ortega, E.; Sánchez, J. L.; Marcos, J. L.; Guerrero-Higueras, A. M.

    2012-04-01

    The location of Castile and León, inside the Iberian Peninsula, in the Northwestern quadrant, determines, in large measure, the climatic conditions of its territory, granting it very characteristic traits, mostly in the mountainous areas. It is important to note that during a large part of the year, the region is under the influence of Jet Stream, and thus, gives way to very diverse dynamic situations, which turn into different and heterogeneous types of weather. So, in many areas of the region, especially in the most elevated areas, these synoptic and mesoscale situations generate snow precipitation. We should point out that snowfall is one of the principal meteorological risks of Castile and León. Thus, on average, in some mountainous areas there are more than 40 events of snowfall registered annually, with the month of January being the month in which the highest frequency of snowfall appears. The social repercussions of this snowfall are represented in the isolation of places, essentially mountainous, highways being blocked, increase in traffic accidents, etc. As proof of this, it is this type of episode that receives ample coverage by the media, which has a linear relationship with the social perception of risk. As such, the objective of the current work is to analyze the annual trend of days with snow in the different meteorological stations pertaining to AEMET placed in the Community. The period of study is from 1960-2010. Additionally, we have also evaluated trends in annual days of freezing temperature and annual absolute minimum temperature, with the objective of facilitating a meteorological interpretation of the trends obtained on days with snowfall. Finally, the results show that in the majority of stations, a significant negative trend in days with snowfall and annual days with freezing temperatures, and a positive trend in annual absolute minimum temperatures. However, we observed variability in the different regions in the area of study

  1. The rôle of planetaria: The Library of Alexandria Planetarium Science Center

    NASA Astrophysics Data System (ADS)

    El-Mitaky, Hoda S.

    2011-06-01

    In ancient times the stars and the Moon were humans' only guide to cross the seas and explore the depths of the deserts. With the use of modern technological gadgets, and the increasingly light pollution, citizens of the world stopped looking at the heavens. How can planetaria play a rôle in reviving public interest in astronomy? How can the beauty of astronomy play a rôle in luring the youth to pursue a career in science? How can astronomy play a rôle in raising public awareness about preserving the environment? Moreover, how can astronomy play a rôle in the dialogue among civilisations?

  2. Le gingembre contre la nausée et les vomissements de la grossesse

    PubMed Central

    Lindblad, Adrienne J.; Koppula, Sudha

    2016-01-01

    Question clinique Le gingembre peut-il traiter la nausée et les vomissements de la grossesse? Résultats Durant le premier trimestre, le gingembre soulagerait la nausée et les vomissements de quelque 4 points sur une échelle de 40 points, ou éliminerait les vomissements chez 1 femme sur 3 au jour 6. L’étude la plus vaste ne laisse croire à aucune hausse des malformations congénitales ou de la mortinatalité, mais les études de moins grande envergure laissent croire le contraire.

  3. 4. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 DETAIL OF WINDOW BREAKING INTO PEDIMENT. - First Congregational Church, 301 Benefit Street, Providence, Providence County, RI

  4. Le consentement libre et éclairé aux soins en psychiatrie

    PubMed Central

    Neilson, Grainne; Chaimowitz, Gary

    2015-01-01

    Résumé Le patient a le droit d’être informé sur les soins de santé qui lui sont proposés et de participer activement à la prise de décisions relativement à ces soins. Le respect de la dignité et de l’autonomie de la personne passe par le respect de son droit de prendre des décisions à propos de ses soins psychiatriques, notamment de refuser un traitement, pour autant qu’elle soit apte à prendre des décisions. Il importe que le psychiatre connaisse les fondements éthiques du consentement libre et éclairé et les exigences prévues par le droit en cette matière, y compris la jurisprudence. Le consentement n’est pas immuable, pouvant changer avec le temps, au fil de l’évolution des conditions et des circonstances. Par conséquent, le consentement doit être un processus continu.

  5. Le genre Tunga Jarocki, 1838 (Siphonaptera : Tungidae). I – Taxonomie, phylogénie, écologie, rôle pathogène

    PubMed Central

    Beaucournu, J.-C.; Degeilh, B.; Mergey, T.; Muñoz-Leal, S.; González-Acuña, D.

    2012-01-01

    Pour la première fois, les 12 espèces actuellement décrites dans le genre Tunga sont étudiées sur le plan de la taxonomie et de la répartition. Divers aspects de leur biologie et leur rôle pathogène sont également envisagés, et en particulier leur phylogénie, leur chorologie, leur phénologie, leur sexe-ratio et leurs dermecos. PMID:23193514

  6. [Pathogenesis of cutaneous lupus erythematosus from LE-prone mice].

    PubMed

    Furukawa, Fukumi; Yoshimasu, Takashi; Kanazawa, Nobuo

    2010-01-01

    Mouse models are similar but not identical to human diseases. However, they are important for research into the pathogenesis underlying autoimmune diseases because they allow us to evaluate similarities and differences between human diseases and mouse models. There are many inbred strains of systemic lupus erythematosus (SLE)-prone mice including New Zealand Black (NZB), F1 hybrids of NZB x New Zealand White (NZW) (B/W F1), MRL/Mp-lpr/lpr (MRL/lpr), and BXSB mice. The postulated etiology of these murine diseases includes many genetic and extrinsic factors such as retroviruses, an impaired balance of T cell interaction, ultraviolet irradiation, etc. For examples, genetic studies of MRL/lpr mice revealed that the appearance of macroscopic LE-like skin lesions needs the lpr mutation plus an additional factor in an autosomal dominant fashion. The candidate is ultraviolet (UV) B light, the susceptibility to which is regulated by the genetic background. Such abnormalities described in SLE now span the spectrum from innate immunity to acquired immunity. In this review, based on historical review, we focus on skin lesions from the well-studied MRL/lpr and B/W F1 mouse and discuss how SLE-prone mice can contribute to a better understanding of cutaneous LE pathogenesis. PMID:20818144

  7. Ascites-induced LeVeen shunt coagulopathy.

    PubMed Central

    Ragni, M V; Lewis, J H; Spero, J A

    1983-01-01

    Ten of 11 patients undergoing peritoneovenous (LeVeen) shunt placement for intractable ascites had disseminated intravascular coagulation (DIC) following the shunt procedure. Intraoperative ascitic fluid specimens revealed fibrin split products (FSP) in high titer (1:100-1:1600) in all patients. Endotoxin was found in 6 of 11 ascitic fluid samples but in no plasma samples. Activated clotting factors, clot inhibitors, excess protein, and fibrinolytic activity were not found in ascitic fluid. Clotting factor levels were much lower than in plasma. Bleeding occurred after operation in two patients; this appeared to be related to the severity of liver dysfunction as demonstrated by elevations of bilirubin, serum glutamic oxalocetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and preoperative DIC. It is concluded that the LeVeen shunt coagulopathy is DIC, and may be related to exposure of the systemic circulation to FSP-rich ascitic fluid that may activate the coagulation mechanism. Bleeding complications do not appear to be related to the severity of the post shunt coagulopathy, but rather to the severity of liver dysfunction and presence of preoperative DIC (probably caused by the liver disease). PMID:6859998

  8. MODeLeR: A Virtual Constructivist Learning Environment and Methodology for Object-Oriented Design

    ERIC Educational Resources Information Center

    Coffey, John W.; Koonce, Robert

    2008-01-01

    This article contains a description of the organization and method of use of an active learning environment named MODeLeR, (Multimedia Object Design Learning Resource), a tool designed to facilitate the learning of concepts pertaining to object modeling with the Unified Modeling Language (UML). MODeLeR was created to provide an authentic,…

  9. CoLeMo: A Collaborative Learning Environment for UML Modelling

    ERIC Educational Resources Information Center

    Chen, Weiqin; Pedersen, Roger Heggernes; Pettersen, Oystein

    2006-01-01

    This paper presents the design, implementation, and evaluation of a distributed collaborative UML modelling environment, CoLeMo. CoLeMo is designed for students studying UML modelling. It can also be used as a platform for collaborative design of software. We conducted formative evaluations and a summative evaluation to improve the environment and…

  10. Use of Mobile Testing System PeLe for Developing Language Skills

    ERIC Educational Resources Information Center

    Titova, Svetlana

    2015-01-01

    One of the objectives of this paper is to investigate the pedagogical impact of both the mobile testing system PeLe (Norway, HiST) and the enquiry-based learning approach on language skills development in the context of mobile-assisted learning. The research aims to work out a methodological framework of PeLe implementation into the language…

  11. Student Mini-Learning Exercise (SMiLE) Cards: Theory into Practice--Now!

    ERIC Educational Resources Information Center

    Tauber, Robert

    Based on the premise that educational psychology is often taught as theory with few opportunities for practical application, the Student Mini-Learning Exercise (SMiLE) Cards are presented to help students apply educational psychology concepts to field experiences. Components of these SMiLE Cards focus on: identification information; the concept…

  12. The ERDA/LeRC Photovoltaic Systems Test Facility

    NASA Technical Reports Server (NTRS)

    Forestieri, A. F.

    1978-01-01

    The ERDA/LeRC Photovoltaic Systems Test Facility (STF) provides a vital support function to the overall ERDA National Solar Photovoltaic Program. It allows preliminary investigation and checkout of components, subsystems, and complete photovoltaic systems before installation in actual service. The STF can also be used to determine optimum system configurations and operating modes. A facility description is presented, taking into account the solar cell array, the energy storage equipment, the power conditioning equipment, electric utility distribution network and loads, and instrumentation and data acquisition systems. Safety procedures which have been set up for maintenance and inspection of the solar array are discussed. Attention is also given to a number of investigations regarding the effect of environmental factors on solar cell array operation.

  13. Design of Multidimensional Shinnar-Le Roux RF Pulses

    PubMed Central

    Ma, Chao; Liang, Zhi-Pei

    2014-01-01

    Purpose To generalize the conventional Shinnar-Le Roux (SLR) method for the design of multidimensional RF pulses. Methods Using echo-planar gradients, the multidimensional RF pulse design problem was converted into a series of 1D polynomial design problems. Each of the 1D polynomial design problems was solved efficiently. B0 inhomogeneity compensation and design of spatial-spectral pulses were also considered. Results The proposed method was used to design 2D excitation and refocusing pulses. The results were validated through Bloch equation simulation and experiments on a 3.0 T scanner. Large-tip-angle, equiripple-error, multidimensional excitation was achieved with ripple levels closely matching the design specifications. Conclusion The conventional SLR method can be extended to design multidimensional RF pulses. The proposed method achieves almost equiripple excitation errors, allows easy control of the tradeoff among design parameters, and is computationally efficient. PMID:24578212

  14. LeRoy Doggett and Daylight Saving Time: A Reminiscence

    NASA Astrophysics Data System (ADS)

    Bartky, I. R.

    1997-12-01

    Daylight Saving Time (DST) has been a concern of Congress ever since its adoption in 1918. Yet, not until 1976 did Members of Congress have astronomical, geographic and demographic information in terms of the country's Standard Time zones. This information and various impact analyses were developed by the National Bureau of Standards (NBS) at the request of the House of Representatives, which was reviewing the effects of a two-year, DST experiment on the American public. The displays in the study gave legislators a way to consider alternate observance periods in a systematic manner. The leader of the DST study team will detail LeRoy Doggett's involvement during the hectic, three-month analysis period that culminated with NBS officials testifying before Congress.

  15. An Overview-NASA LeRC Structures Program

    NASA Technical Reports Server (NTRS)

    Zaretsky, Erwin V.

    1997-01-01

    The Structures and Acoustics Division of the NASA Lewis Research Center has its genesis dating back to 1943. It has been an independent Division at Lewis since 1979. Its two primary capabilities are performance and life analysis of static and dynamic systems such as those found in aircraft and spacecraft propulsion systems and experimental verification of these analyses. Research is conducted in-house, through university grants and contracts, and through cooperative programs with industry. Our work directly supports NASA's Advanced Subsonic Technology (AST), Smart Green Engine, Fast Quiet Engine, High-Temperature Materials and Processing (HiTEMP), Hybrid Hyperspeed Propulsion, Rotorcraft, High-Speed Research (HSR), and Aviation Safety Program (AvSP). A general overview is given discussing these programs and other technologies that are being developed at NASA LeRC.

  16. The NASA-LeRC wind turbine sound prediction code

    NASA Astrophysics Data System (ADS)

    Viterna, L. A.

    1981-05-01

    Since regular operation of the DOE/NASA MOD-1 wind turbine began in October 1979 about 10 nearby households have complained of noise from the machine. Development of the NASA-LeRC with turbine sound prediction code began in May 1980 as part of an effort to understand and reduce the noise generated by MOD-1. Tone sound levels predicted with this code are in generally good agreement with measured data taken in the vicinity MOD-1 wind turbine (less than 2 rotor diameters). Comparison in the far field indicates that propagation effects due to terrain and atmospheric conditions may be amplifying the actual sound levels by about 6 dB. Parametric analysis using the code has shown that the predominant contributions to MOD-1 rotor noise are: (1) the velocity deficit in the wake of the support tower; (2) the high rotor speed; and (3) off column operation.

  17. The NASA-LeRC wind turbine sound prediction code

    NASA Technical Reports Server (NTRS)

    Viterna, L. A.

    1981-01-01

    Since regular operation of the DOE/NASA MOD-1 wind turbine began in October 1979 about 10 nearby households have complained of noise from the machine. Development of the NASA-LeRC with turbine sound prediction code began in May 1980 as part of an effort to understand and reduce the noise generated by MOD-1. Tone sound levels predicted with this code are in generally good agreement with measured data taken in the vicinity MOD-1 wind turbine (less than 2 rotor diameters). Comparison in the far field indicates that propagation effects due to terrain and atmospheric conditions may be amplifying the actual sound levels by about 6 dB. Parametric analysis using the code has shown that the predominant contributions to MOD-1 rotor noise are: (1) the velocity deficit in the wake of the support tower; (2) the high rotor speed; and (3) off column operation.

  18. Dynamic response of the cavitating LE-7 LOX pump

    NASA Astrophysics Data System (ADS)

    Shimura, Takashi; Watanabe, Mitsuo; Ujino, Isao

    The dynamic response of the LE-7 engine LOX pump under cavitating conditions was investigated by perturbation tests using cryogenic fluid in order to obtain data for the analysis of the H-II rocket POGO phenomena. Mass flow gain factor, M(sub b), and cavitation compliance, C(sub b), were determined by pressure data using resonant frequency. M(sub b) and C(sub b) show cavity volume change rates due to flow fluctuation and pressure fluctuations, respectively. A large accumulator was installed in the vicinity of the pump inlet in order to eliminate the upstream effects. The test results of M(sub b) agreed well with the values calculated by equations presented in the literature. However, the test results of C(sub b) were quite different from the calculated values.

  19. Neptune's Discovery: Le Verrier, Adams, and the Assignment of Credit

    NASA Astrophysics Data System (ADS)

    Sheehan, William

    2011-01-01

    As one of the most significant achievements of 19th century astronomy, the discovery of Neptune has been the subject of a vast literature. A large part of this literature--beginning with the period immediately after the optical discovery in Berlin--has been the obsession with assigning credit to the two men who attempted to calculate the planet's position (and initially this played out against the international rivalry between France and England). Le Verrier and Adams occupied much different positions in the Scientific Establishments of their respective countries; had markedly different personalities; and approached the investigation using different methods. A psychiatrist and historian of astronomy tries to provide some new contexts to the familiar story of the discovery of Neptune, and argues that the personalities of these two men played crucial roles in their approaches to the problem they set themselves and the way others reacted to their stimuli. Adams had features of high-functioning autism, while Le Verrier's domineering, obsessive, orderly personality--though it allowed him to be immensely productive--eventually led to serious difficulties with his peers (and an outright revolt). Though it took extraordinary smarts to calculate the position of Neptune, the discovery required social skills that these men lacked--and thus the process to discovery was more bumbling and adventitious than it might have been. The discovery of Neptune occurred at a moment when astronomy was changing from that of heroic individuals to team collaborations involving multiple experts, and remains an object lesson in the sociological aspects of scientific endeavor.

  20. Dysfonctionnements radio-induits du transport colique chez le rat

    NASA Astrophysics Data System (ADS)

    François, A.; Lebrun, F.; Ksas, B.; Aigueperse, J.; Gourmelon, P.; MacNaughton, W. K.; Griffiths, N. M.

    1998-04-01

    The symptom commonly associated with whole body irradiation is diarrhoea, a still quite obscure phenomenon, which leads to decreased chance of cure of irradiated people. The aim of this study was to provide evidence for dysfunction of intestinal water and electrolyte transport regulation by the enteric nervous system after exposure to ionising radiation. This study shows decreased capacity of enteric nervous system to influence colonic transport 3days after irradiation, correlated to a diminished response to a neurotransmitter: serotonin. Radio-induced diarrhea may result from epithelial structural injury but also from impaired regulatory processes of intestinal transport. L'un des symptômes majeurs d'une irradiation corporelle totale ou abdominale est l'apparition de diarrhées, dont les causes sont encore mal connues, et qui mettent en jeu le pronostique vital de l'individu irradié. Cette étude vise à mettre en évidence l'atteinte de la régulation du transport intestinal d'eau et d'électrolytes par les rayonnements ionisants. On observe une diminution de la capacité du système nerveux entérique à influencer le transport colique 3jours après irradiation, corrélée à une diminution de la réponse épithéliale à un neurotransmetteur : la sérotonine. Les diarrhées radio-induites résulteraient d'une atteinte structurelle de l'épithélium mais également des processus de régulation du transport intestinal.

  1. Overexpression of the tomato pollen receptor kinase LePRK1 rewires pollen tube growth to a blebbling mode

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The tubular growth of a pollen tube cell is crucial for the sexual reproduction of flowering plants. LePRK1 is a pollen-specific and plasma membrane–localized receptor-like kinase from tomato (Solanum lycopersicum). LePRK1 interacts with another receptor, LePRK2, and with KINASE PARTNER PROTEIN (KPP...

  2. Les fluctuations supraconductrices dans le compose praseodyme-cerium-oxyde de cuivre

    NASA Astrophysics Data System (ADS)

    Renaud, Jacques

    Ce travail etudie les fluctuations supraconductrices dans le compose supraconducteur a haute temperature critique dope aux electrons Pr2-xCe xCuO4+delta. La technique utilisee pour sonder ces fluctuations est le transport electrique DC dans le plan ab. Il s'agit, a notre connaissance, de la premiere etude de ce type dans la classe generale des supraconducteurs a haute temperature critique dopes aux electrons et, plus particulierement, dans Pr2-xCe xCuO4+delta. De plus, l'etude est effectuee pour trois regimes de dopage, soit sous-dope x = 0.135, dopage optimal x = 0.15 et surdope x = 0.17. Les echantillons etudies sont des couches minces d'epaisseur plus grande que 100 nm crues par ablation laser. Les mesures electriques DC effectuees dans ce travail sont la resistance en reponse lineaire et les courbes IV en reponse non lineaire en fonction de la temperature. La mise en oeuvre experimentale de ces mesures a necessite une grande attention au filtrage et aux effets de chauffage a haut courant. Nous montrons que, sans cette attention, les donnees experimentales sont toujours erronees dans le regime pertinent pour nos echantillons. Les resultats pour le dopage optimal x = 0.15 sont expliques de facon tres convaincante dans le cadre de fluctuations purement 2D. D'abord, le regime des fluctuations gaussiennes est tres bien decrit par le modele d'Aslamazov-Larkin en deux dimensions. Ensuite, le regime de fluctuations critiques, se trouvant a plus basse temperature que le regime gaussien, est tres bien decrit par la physique 2D de Kosterlitz-Thouless. Dans cette analyse, les deux regimes ont des temperatures critiques coherentes entre elles, ce qui semble confirmer ce scenario 2D. Une analyse des donnees dans le cadre de fluctuations 3D est exploree mais donne des conclusions incoherentes. Les resultats pour les autres dopages sont qualitativement equivalents avec le dopage optimal et permettent donc une explication purement 2D. Par contre, contrairement au dopage optimal

  3. LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels

    PubMed Central

    Yin, Shijin; Luo, Jialie; Qian, Aihua; Yu, Weihua; Hu, Hongzhen

    2014-01-01

    Background and PurposeRetinoids, through their activation of retinoic acid receptors (RARs) and retinoid X receptors, regulate diverse cellular processes, and pharmacological intervention in their actions has been successful in the treatment of skin disorders and cancers. Despite the many beneficial effects, administration of retinoids causes irritating side effects with unknown mechanisms. Here, we demonstrate that LE135 [4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid], a selective antagonist of RARβ, is a potent activator of the capsaicin (TRPV1) and wasabi (TRPA1) receptors, two critical pain-initiating cation channels. Experimental ApproachWe performed to investigate the excitatory effects of LE135 on TRPV1 and TRPA1 channels expressed in HEK293T cells and in dorsal root ganglia neurons with calcium imaging and patch-clamp recordings. We also used site-directed mutagenesis of the channels to determine the structural basis of LE135-induced activation of TRPV1 and TRPA1 channels and behavioural testing to examine if pharmacological inhibition and genetic deletion of the channels affected LE135-evoked pain-related behaviours. Key ResultsLE135 activated both the capsaicin receptor (TRPV1) and the allyl isothiocyanate receptor (TRPA1) heterologously expressed in HEK293T cells and endogenously expressed by sensory nociceptors. Mutations disrupting the capsaicin-binding site attenuated LE135 activation of TRPV1 channels and a single mutation (K170R) eliminated TRPA1 activity evoked by LE135. Intraplantar injection of LE135 evoked pain-related behaviours. Both TRPV1 and TRPA1 channels were involved in LE135-elicited pain-related responses, as shown by pharmacological and genetic ablation studies. Conclusions and ImplicationsThis blocker of retinoid acid signalling also exerted non-genomic effects through activating the pain-initiating TRPV1 and TRPA1 channels. PMID:24308840

  4. [Redéfinir le leadership éthique dans le système de santé du XXIe siècle].

    PubMed

    Ho, Anita; Pinney, Stephen

    2016-01-01

    Dans le milieu de la santé, le leadership éthique classique est axé sur la supervision de la relation entre le professionnel de la santé et le patient. Cependant, puisque la prestation des soins dépend désormais essentiellement d'une équipe et qu'elle est intégrée entre organisations de la santé, ces cadres éthiques doivent tenir compte de facteurs mésoscopiques et macroscopiques. En raison de ces enjeux plus vastes, les gestionnaires et les leaders administratifs doivent adopter des perspectives éthiques qui, loin de se limiter aux patients actuels et prospectifs, incluent également l'équipe, l'organisation et l'ensemble du système, où il est essentiel d'assurer un taux élevé de coordination et de surveillance. Les administrateurs ont une responsabilité éthique croissante, non seulement envers le déroulement de chaque rencontre de soins (microscopique), mais également envers l'organisation du système pour prodiguer et garantir des soins de qualité aux patients (mésoscopique) et les services aux populations qui leur demandent des soins lorsqu'elles en ont besoin (macroscopique).

  5. Synthesis, characterization, phase diagrams and superconducting and normal state magnetic properties of La{sub 2{minus}x}Sr{sub x}CuO{sub 4} (0 {le} x {le} 0.08) and electrochemically oxidized La{sub 2{minus}x}Sr{sub x}CuO{sub 4+{delta}} (0 {le} x {le} 0.33, 0 {le} {delta} {le} 0.12)

    SciTech Connect

    Chou, F.

    1993-08-01

    La{sub 2{minus}x}Sr{sub x}CuO{sub 4} (0 {le} x {le} 0.15) can all be intercalated with oxygen by a novel electrochemical oxidation method. Bulk superconductivity is found with an onset {Tc} {approx} 40 K for the whole range 0.01 {le} x {le} 0.15; for x = 0.25 and 0.33, the electrochemical oxidation did not improve the superconducting properties. The magnetic susceptibility {chi}(T = 50--320 K) data for La{sub 2}CuO{sub 4.11} and La{sub 1.92}Sr{sub 0.08}CuO{sub 4.07} are nearly identical with those of conventionally prepared La{sub 1.85}Sr{sub 0.15}CuO{sub 4}, indicating that the hole doping level (p) in the CuO{sub 2} planes of the three compounds is nearly the same. Combined thermogravimetric analysis and iodometric titration experiments indicate that part of the intercalated oxygen has a formal valence close to {minus}1. The maximum doped-hole concentration in the CuO{sub 2} planes that can be achieved from combined Sr-doping and electrochemical oxygen doping for 0 {le} x {le} 0.15 is p {approx} 0.16 holes/formula unit. Oxygen can also intercalate into single crystal La{sub 2}CuO{sub 4} through a slow electrochemical oxidation process. The required low current and long time for the charging process reflects that the oxygen intercalation for a single crystal is limited by its small specific surface area and long diffusion distance. The anisotropic superconducting, magnetic and transport properties are summarized and compared with those of polycrystalline La{sub 2}CuO{sub 4+{delta}} as well as of YBa{sub 2}Cu{sub 3}O{sub 7{minus}{delta}} and La{sub 2{minus}x}Sr{sub x}CuO{sub 4} single crystals. The single crystal La{sub 2}CuO{sub 4+{delta}} has a maximum {Tc} {approx} 40 K, which is lower than that ({Tc} {approx} 42--45) of the corresponding polycrystalline samples. The magnetic phase diagram of La{sub 2{minus}x}Sr{sub x}CuO{sub 4} in the antiferromagnetic (AF) regime (0 {le} x {le} 0.02) has been derived from {sup 139}La NQR studies from 4 to 250 K.

  6. The occurrence of blood group substances (A, B, H, Le-a, Le-b) in salivary glands and salivary gland tumors. An immunohistochemical investigation.

    PubMed

    Hamper, K; Caselitz, J; Seifert, G; Seitz, R; Poschmann, A

    1986-07-01

    The distribution of blood group substances A, B, H, Le-a and Le-b in normal and neoplastic salivary gland tissue was evaluated by means of immunohistochemistry. The serological ABH blood group status of one third of the patients was known. Lewis blood group and secretory status were not known. In normal tissue, expression of blood group antigens corresponded to the serological blood group. Blood group substance H was present in almost every gland, regardless of the serological blood group. In submandibular glands, Le-b was rather selective for mucous acini. In tumors, a relationship of blood group expression to a glandular pattern and a high differentiation could be observed. Blood group substances were expressed at a high level in benign and highly differentiated malignant tumors. In poorly differentiated malignant tumors, they were mostly absent. Blood group expression evaluation could be of value in establishing the level of functional differentiation in salivary gland tumors.

  7. Piecemeal Versus En Bloc Resection of Large Rectal Adenomas

    ClinicalTrials.gov

    2016-05-10

    Colorectal Adenoma With Mild Dysplasia; Colorectal Adenoma With Severe Dysplasia; Colorectal Adenomatous Polyp; Colorectal Low Grade Intraepithelial Neoplasia; Colorectal High Grade Intraepithelial Neoplasia

  8. Portevin-Le Chatelier effect and Tsallis nonextensive statistics

    NASA Astrophysics Data System (ADS)

    Iliopoulos, A. C.; Nikolaidis, N. S.; Aifantis, E. C.

    2015-11-01

    In this paper, we estimate Tsallis' entropic index q ≡qstat (stat denotes stationary states) for various stress serration time series of Cu-15%Al alloys corresponding to different deformation temperatures and types (A, B, C) of Portevin-Le Chatelier (PLC) bands. Tsallis statistical analysis is also conducted on experimental data derived from correlation diagrams focusing on PLC type C bands' spatial organization at the surface of various specimens. The results concerning the stress serrations analysis reveal the non-Gaussian (Tsallis q-Gaussian), nonextensive, sub-additive, character of the underlying dynamics of the PLC type-A bands (q > 1) indicating dynamics at the edge of chaos, with global long range correlations and power law scaling. Similarly, for PLC type B bands, a Tsallis q-Gaussian, non-extensive, super-additive, statistical profile was found with q < 1, while for the PLC type C bands, a near Boltzmann-Gibbs (BG) statistical character was verified indicating Gaussian dynamics with short (weak) range correlations. Finally, Tsallis q-index for the spatial data of PLC type C bands was found above unity (q > 1) indicating that type C bands are not randomly nucleated in the specimen (e.g. yielding a Gaussian distribution) but there exist spatial coupling and long range deformation correlations in the PLC type C bands spatial localization.

  9. 'Le roi le veult'.

    PubMed

    Sholl, W T

    1997-06-14

    Following the fiftieth anniversary of the National Health Service Act 1946, I make the case in this article that professional provision of health care must remain the property of the citizen under common law and must not become a commodity that is bought and sold by third parties, including the state.

  10. 16. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Historic American Buildings Survey, Arthur W. LeBoeuf, Photographer, 1937 FIREPLACE SET WITH BIBLICAL TILES, NORTHEAST ROOM. - Nichols-Wanton-Hunter House, 54 Washington Street, Newport, Newport County, RI

  11. A Multistep Equilibria-Redox-Complexation Demonstration to Illustrate Le Chatelier's Principle.

    ERIC Educational Resources Information Center

    Berger, Tomas G.; Mellon, Edward K.

    1996-01-01

    Describes a process that can be used to illustrate a number of chemical principles including Le Chatelier's principle, redox chemistry, equilibria versus steady state situations, and solubility of species. (JRH)

  12. An Overhead Demonstration of Some Descriptive Chemistry of the Halogens and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Hansen, Robert C.

    1988-01-01

    Describes a demonstration procedure using controlled reduction potentials to predict observed color changes which are then experimentally verified. Demonstrates the usefulness of this procedure in helping students understand LeChatelier's principle and the solubilit rule "like dissolves like." (CW)

  13. Landau and Lifshitz' formulation of Le Chatelier's principle: an insight into symbiosis?

    PubMed

    Halabi, T

    2013-12-01

    A correspondence allows application of Landau and Lifshitz' formulation of Le Chatelier's principle from statistical physics to a simple 2-D model of biological symbiosis. The insight: symbionts stabilize the occupation of narrow peaks on fitness landscape. PMID:23851635

  14. 7. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 SOUTH (FRONT) ELEVATION. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  15. 14. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 INTERIOR DETAIL, SOUTHEAST BEDROOM. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  16. 4. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 SOUTHWEST ELEVATION. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  17. 3. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 NORTHEAST ELEVATION. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  18. 10. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 MANTEL (NOT ORIGINAL) SOUTHEAST PARLOR. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  19. Le volvulus gastrique idiopathique aigu: à propos d'une nouvelle observation

    PubMed Central

    Abdelilah, Mouhsine; Jihad, Anzaoui; Rachid, Bouchentouf

    2013-01-01

    Le volvulus gastrique est une rotation anormale de l'estomac autour de son axe. La forme aiguë constitue une urgence chirurgicale. Le diagnostic est souvent retardé en raison d'une symptomatologie fréquemment non spécifique. Des signes respiratoires tels la dyspnée et le hoquet peuvent révéler cette pathologie. Les auteurs rapportent une nouvelle observation de volvulus gastrique aigu chez un adolescent de 17 ans, diagnostiqué par la tomodensitométrie, et confirmé par une intervention chirurgicale. Le traitement est chirurgical et consiste à détordre et fixer l'estomac pour prévenir la récidive. PMID:23503200

  20. Facteurs de risque de l'infection par le VIH dans le district de santé de Meyomessala au Cameroun

    PubMed Central

    Mbopi-Keou, Francois-Xavier; Nguefack-Tsague, Georges; Kalla, Ginette Claude Mireille; Abessolo, Stéphanie Abo'o; Angwafo, Fru; Muna, Walinjom

    2014-01-01

    Introduction L'objectif de ce travail était de déterminer les facteurs de risque de l'infection par le VIH dans le district de santé de Meyomessala (Région du Sud) au Cameroun. Méthodes Il s'agissait d'une étude transversale, descriptive et analytique qui s'est déroulée de Février à Mai 2011. Pour cette étude, nous avons obtenu une clairance éthique. Résultats L’échantillon était constitué de 315 participants dont 181 (57,46%) hommes et 134 (42,54%) femmes. L’âge moyen était de 24,5±8ans (extrême: 15-45ans). Quarante personnes (40) étaient séropositifs, soit une prévalence de l'infection par le VIH de 12,7%. Cette prévalence augmentait significativement (p = 0) avec le nombre de partenaires occasionnels au cours des douze derniers mois, allant de 2,7% chez ceux n'ayant eu aucun partenaire occasionnel à 21,25% chez ceux ayant plus de trois partenaires occasionnels (RC = 9,72; IC = 1,27-74,14; P = 0,03). le fait d’être âgé entre 20 et 24 ans (RC = 4,88; IC = 1,74-13,67; p = 0), avoir plus de trois partenaires sexuels au cours des douze derniers mois (RC = 9,72; IC = 1,27-74,14; p = 0,03), avoir les rapports sexuels avec les prostitués (RC = 2,86; IC = 1,42-5,76; p = 0), avoir eu le chlamydia (RC = 3,00; IC = 1,07-8,39; p = 0,04), avoir eu la syphilis (RC = 3,35; IC = 1,57-7,14; p = 0), avoir des avantages sociaux lors du premier rapport sexuel (RC = 2,57; IC = 1,03-6,43; p = 0,04) constituaient des potentiels facteurs de risque du VIH. Conclusion Il apparait urgent d'intensifier les campagnes de sensibilisation au risque d'infection par le VIH et les maladies sexuellement transmissibles dans le district de santé de Meyomessala PMID:25419299

  1. Facteurs déterminants le regret après ligature tubaire

    PubMed Central

    Boufettal, Houssine; Mahdaoui, Sakher; Samouh, Naïma

    2014-01-01

    Introduction La ligature tubaire peut générer regret. Le but de cette étude est d’étudier le vécu après la stérilisation ainsi que le regret et ses facteurs de risque. Méthodes Il s'agit d'une étude rétrospective chez 52 femmes stérilisées entre 2004 et 2010. Résultats Vingt cinq (48%) femmes avaient regretté la réalisation de la ligature tubaire. La moyenne d’âge était de 40,5 ans. Le temps consacré aux explications était très court dans tous les cas. Trois quart des femmes n’était pas au courant des complications de la ligature tubaire. Le regret était dû au facteur religieux (23%), aux algies pelviennes (11,5%), au désir d'autres enfants (9,6%) ou à la prise de connaissance d'autres moyens contraceptifs (3,9%). Conclusion Un certains nombre de facteurs de risque de regret de la ligature tubaire sont retrouvés dans la littérature, comme dans notre série, dont l’âge, le désir de procréer, l'information incomplète, le délai de réflexion et le facteur religieux. PMID:25309644

  2. Le Châtelier reciprocal relations and the mechanical analog

    NASA Astrophysics Data System (ADS)

    Gilmore, Robert

    1983-08-01

    Le Châtelier's principle is discussed carefully in terms of two sets of simple thermodynamic examples. The principle is then formulated quantitatively for general thermodynamic systems. The formulation is in terms of a perturbation-response matrix, the Le Châtelier matrix [L]. Le Châtelier's principle is contained in the diagonal elements of this matrix, all of which exceed one. These matrix elements describe the response of a system to a perturbation of either its extensive or intensive variables. These response ratios are inverses of each other. The Le Châtelier matrix is symmetric, so that a new set of thermodynamic reciprocal relations is derived. This quantitative formulation is illustrated by a single simple example which includes the original examples and shows the reciprocities among them. The assumptions underlying this new quantitative formulation of Le Châtelier's principle are general and applicable to a wide variety of nonthermodynamic systems. Le Châtelier's principle is formulated quantitatively for mechanical systems in static equilibrium, and mechanical examples of this formulation are given.

  3. [LE cells in synovial fluid: prevalence and diagnostic usefulness in rheumatic diseases].

    PubMed

    Puszczewicz, Mariusz; Białkowska-Puszczewicz, Grazyna

    2010-01-01

    This study was undertaken to determine the prevalence of LE cells in synovial fluid and their importance for the diagnosis of rheumatic disease. Synovial fluid was obtained from 631 patients: 31 with systemic lupus erythematosus (SLE), 337 with rheumatoid arthritis (RA), 4 with Still's disease, 9 with systemic scleroderma (SS), 27 with the overlap syndrome (RA/SLE), 132 with ankylosing spondylitis (AS), 57 with Reiter's syndrome, and 34 with psoriatic arthritis (PA). The fluid was centrifuged, precipitate smears were done and were May-Grünwald-Giemsa stained for cytologic assessment. The supernatant was collected for antinuclear antibody (ANA) testing. Physicochemical and serologic properties of the synovial fluid were routinely determined. All synovial fluids demonstrated signs of inflammation. The presence of LE cells was ascertained in five patients with SLE and nine patients with the overlap syndrome. In these cases, LE cells were accompanied by ANA. In addition, hematoxylin bodies were revealed in SLE patients. LE cells were observed in 2.6% of patients with RA but were not accompanied by ANA. Patients with SS, Still's disease, AS, Reiter's syndrome, and PA tested negative for LE cells. It appears from these results that LE cells are rarely present in the synovial fluid of patients with rheumatic diseases. In contrast, they occur in more than 40% of patients with the overlap syndrome and may thus be regarded as important for the diagnosis of this condition. PMID:21365954

  4. SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes.

    PubMed

    Shen, Yue; Stracquadanio, Giovanni; Wang, Yun; Yang, Kun; Mitchell, Leslie A; Xue, Yaxin; Cai, Yizhi; Chen, Tai; Dymond, Jessica S; Kang, Kang; Gong, Jianhui; Zeng, Xiaofan; Zhang, Yongfen; Li, Yingrui; Feng, Qiang; Xu, Xun; Wang, Jun; Wang, Jian; Yang, Huanming; Boeke, Jef D; Bader, Joel S

    2016-01-01

    Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then used a computational pipeline to infer or unscramble the sequence of recombinations that created the observed genomes. Deep sequencing of 64 synIXR SCRaMbLE strains revealed 156 deletions, 89 inversions, 94 duplications, and 55 additional complex rearrangements; several duplications are consistent with a double rolling circle mechanism. Every SCRaMbLE strain was unique, validating the capability of SCRaMbLE to explore a diverse space of genomes. Rearrangements occurred exclusively at designed loxPsym sites, with no significant evidence for ectopic rearrangements or mutations involving synthetic regions, the 99% nonsynthetic nuclear genome, or the mitochondrial genome. Deletion frequencies identified genes required for viability or fast growth. Replacement of 3' UTR by non-UTR sequence had surprisingly little effect on fitness. SCRaMbLE generates genome diversity in designated regions, reveals fitness constraints, and should scale to simultaneous evolution of multiple synthetic chromosomes. PMID:26566658

  5. SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes.

    PubMed

    Shen, Yue; Stracquadanio, Giovanni; Wang, Yun; Yang, Kun; Mitchell, Leslie A; Xue, Yaxin; Cai, Yizhi; Chen, Tai; Dymond, Jessica S; Kang, Kang; Gong, Jianhui; Zeng, Xiaofan; Zhang, Yongfen; Li, Yingrui; Feng, Qiang; Xu, Xun; Wang, Jun; Wang, Jian; Yang, Huanming; Boeke, Jef D; Bader, Joel S

    2016-01-01

    Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then used a computational pipeline to infer or unscramble the sequence of recombinations that created the observed genomes. Deep sequencing of 64 synIXR SCRaMbLE strains revealed 156 deletions, 89 inversions, 94 duplications, and 55 additional complex rearrangements; several duplications are consistent with a double rolling circle mechanism. Every SCRaMbLE strain was unique, validating the capability of SCRaMbLE to explore a diverse space of genomes. Rearrangements occurred exclusively at designed loxPsym sites, with no significant evidence for ectopic rearrangements or mutations involving synthetic regions, the 99% nonsynthetic nuclear genome, or the mitochondrial genome. Deletion frequencies identified genes required for viability or fast growth. Replacement of 3' UTR by non-UTR sequence had surprisingly little effect on fitness. SCRaMbLE generates genome diversity in designated regions, reveals fitness constraints, and should scale to simultaneous evolution of multiple synthetic chromosomes.

  6. Architectural Kansei of ‘Wall’ in The Façade Design by Le Corbusier

    NASA Astrophysics Data System (ADS)

    Sendai, Shoichiro

    The purpose of this paper is to discuss the modern architect Le Corbusier's architectural Kansei (sensibility) on wall in site environment through the analysis of his façade design, using Œuvres complètes (1910-1965, 8 vols., Les éditions d'architecture, Artemis, Zurich) and Le Corbusier Archives (1982-1984, 32 vols., Garland Publishing, Inc. and Fondation Le Corbusier, New York, London, Paris). At first, I arrange five façade types, according to the explanation by Le Corbusier ; ‘fenêtre en longueur (strip window)’, ‘pan de verre (glass wall)’, ‘brise-soleil (sun-breaker)’, ‘loggia’ and ‘claustra’. Through the analysis of the relationship between these types and the design process of each building, we find that Le Corbusier's façade design includes the affirmation and the negation of the ‘wall’ at the same time. In fact, the nature of façade modification during design process is divers: increase in transparency, decrease in transparency and spatialization of façade. That means, Le Corbusier studied the environmental condition by these façade types, and tried to realize the phenomenal openness. This trial bases on the function of architectural Kansei as correspondence between body and environment beyond the physical design.

  7. Lymphome et grossesse: le point de vue de l'obstétricien, à propos de 2 cas

    PubMed Central

    Amourak, Sarah; Alaoui, Fatimazahra Fdili; Jayi, Sofia; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2014-01-01

    L'association lymphome et grossesse est une situation rare, mais non exceptionnelle, relevant de la coïncidence. Le lymphome vient en 4ème position des cancers rencontrés chez la femme enceinte, La clinique est trompeuse et inconstante, le diagnostic reste histologique et on distingue 2 types: lymphome malin hodgkinien (LMH) et le lymphome malin non hodgkinien (LMNH). Malgré le contexte de véritable urgence hématologique, la décision d'initier ou de différer le traitement est délicate, influencée par le type de lymphome, son extension et sa localisation, la répercussion organique, le degré de maturation f'tale, les risques obstétricaux et les valeurs éthiques, culturelles et religieuses de la patiente. Le traitement consiste essentiellement à une chimiothérapie. Le LH durant la grossesse est relativement moins agressif et d’évolution plus favorable que le LMNH. PMID:25883744

  8. Intrication de deux atomes en utilisant le blocage de Rydberg

    NASA Astrophysics Data System (ADS)

    Gaëtan, A.

    2010-12-01

    Considérons un système quantique constitué de deux sous-systèmes : on dit qu'il est dans un état intriqué s'il existe des corrélations quantiques entre les états de ces derniers. La compréhension et la mise en œuvre d'états intriqués ont de nombreuses applications (métrologie quantique, étude des systèmes fortement corrélés, traitement quantique de l'information, etc.) et constituent le contexte général de ce travail de thèse. Plus en détail, nous démontrons la réalisation d'un état intriqué de deux atomes neutres piégés indépendamment. Pour cela, nous exploitons le phénomène de blocage de Rydberg : lorsqu'on essaie d'exciter simultanément deux atomes séparés de quelques micromètres vers un état de Rydberg donné, la forte interaction entre atomes de Rydberg peut empêcher cette excitation simultanée. Dans ce cas, seul un des deux atomes est excité et l'on génère ainsi des corrélations quantiques entre les états des deux atomes, c'est-à-dire de l'intrication. Dans notre expérience, deux atomes de 87Rb dans l'état fondamental 5S1/2 sont piégés chacun dans une pince optique microscopique, à une distance relative de 4 micromètres. En réalisant des transitions entre l'état 5S1/2 et l'état de Rydberg 58D3/2 par des transitions à deux photons, nous obtenons un état intriqué des deux atomes dans les sous-niveaux |5S1/2, f = 1, mf = 1> et |5S1/2, f = 2, mf = 2>. Afin de quantifier l'intrication, nous mesurons la fidélité par rapport à l'état-cible en réalisant des transitions Raman entre ces deux sous-niveaux. La fidélité des paires d'atomes présentes à la fin de l'expérience est supérieure à la valeur seuil de 0,5, ce qui prouve la création d'un état intriqué.

  9. Évolution des lignes directrices sur le traitement de la dyslipidémie

    PubMed Central

    John Bosomworth, N.

    2014-01-01

    Résumé Objectif Comprendre comment les nouvelles lignes directrices sur la prise en charge du risque cardiovasculaire publiées par l’American Heart Association et l’American College of Cardiology (AHA-ACC) peuvent être interprétées et utilisées dans le contexte canadien. Sources des données Les lignes directrices de l’AHA-ACC ont été examinées, de même que toutes les références. Des recherches indépendantes dans PubMed ont été effectuées pour inclure l’ajout aux statines d’autres antihyperlipidémiants et l’emploi de calculatrices médicales visant à aider le patient à comprendre. Message principal Les nouvelles lignes directrices de l’AHA-ACC s’appuient sur les meilleures données probantes disponibles actuellement en matière de traitement de la dyslipidémie. Cela inclut le risque cardiovasculaire (CV) sur 10 ans comme seuil thérapeutique au lieu du taux de cholestérol des lipoprotéines de faible densité, de même que l’abandon des cibles thérapeutiques de lipoprotéines de faible densité. On met de plus en plus l’accent sur les interventions alimentaires et l’exercice, avec l’amorce d’un effort pour quantifier l’effet de ces interventions. Les statines constituent la principale intervention pharmacologique, et l’ajout d’autres médicaments pour accentuer la baisse lipidique n’est plus recommandé. En ce qui concerne l’application au Canada, les tables de risque de Framingham sont plus appropriées pour évaluer le risque que les équations de cohortes regroupées utilisées aux États-Unis. Les calculatrices du risque de maladie cardiovasculaire (MCV) devraient contenir de l’information sur l’âge cardiovasculaire et devraient pouvoir illustrer le risque et les interventions de rechange afin d’aider le patient à comprendre et de favoriser la prise de décision éclairée. Conclusion L’attention sur les meilleures données probantes concernant le risque CV peut simplifier le traitement de la

  10. le de l'hydrogène dans le procédé de purification du silicium par plasma thermique inductif

    NASA Astrophysics Data System (ADS)

    Erin, J.; Morvan, D.; Amouroux, J.

    1993-03-01

    The use of the thermal process for purification of silicon led to a material with the chemical purity required for phototovoltaic applications. In this paper, the various properties of ArH2 plasma mixtures are briefly reviewed and the effect of hydrogen percentage in an argon plasma used for melting and purifying silicon is pointed out. Physico-chemical analysis of the purified silicon showed that hydrogen diffused in the material and could passivate crystal defects by formation of stable chemical bonds such as Si-H. La technique de purification du silicium sous plasma thermique permet d'aboutir à un matériau de pureté chimique requise pour l'industrie photovoltaïque. Dans ce travail, nous soulignerons lele de l'hydrogène intervenant dans les propriétés du plasma en rappelant les caractéristiques des plasmas Ar-H2 utilisés pour fondre et purifier le silicium. Les caractéristiques physico-chimiques du silicium purifié montrent que l'hydrogène diffuse dans le matériau et est en mesure de cicatriser les défauts cristallins par formation de liaisons chimiques stables de type Si-H.

  11. Un Exemple d'approche notionelle dans le cadre du francais fondamental (An Example of a Conceptual Approach within the Framework of "Le Francais fondamental")

    ERIC Educational Resources Information Center

    Combe-McBride, Nicole

    1977-01-01

    An inventory of grammatical and lexical units expressing the notion of place in "Le Francais fondamental," Level One. Interrelationships are discussed from the point of view of vocabulary patterns and syntax. There are numerous tables and examples of interrelated verbs, adverbs, nouns, and prepositions. (Text is in French.) (AMH)

  12. La plastie en rail dans le traitement des brides rétractiles du creux poplite

    PubMed Central

    Achbouk, A.; Khales, A.; Bourra, K.; Tourabi, K.; Ababou, K.; Ihrai, H.

    2011-01-01

    Summary Les Auteurs décrivent le cas d’un patient âgé de 45 ans atteint de brûlures thermiques par flammes suite à la déflagration d’une bonbonne de gaz. Les lésions initiales intéressaient les quatre membres (en particulier, le genou) et le tronc. La prise en charge initiale a consisté en une excision-greffe précoce des membres. L’évolution a été marquée par la survenue de cicatrices hypertrophiques au niveau des zones non greffées et à la bordure de la greffe ainsi que la survenue de brides rétractiles. Devant l’handicap fonctionnel engendré par la bride à cause de la limitation importante de l’extension, le patient a été admis pour cure chirurgicale. Grâce à la technique en rail décrite, le patient a pu récupérer une fonction normale du genou. Les suites ont été simples avec une durée d’hospitalisation d’un mois. Le résultat esthétique est relativement satisfaisant. La technique en rail est un moyen parmi l’arsenal thérapeutique qui permet de traiter la bride du creux poplité. Sa simplicité, sa facilité technique et son résultat satisfaisant ainsi que ses suites simples permettent de la rendre une technique très prisée dans le traitement de ce type de bride. PMID:21991240

  13. Tumeur de vessie chez le sujet jeune: à propos de 36 cas

    PubMed Central

    Statoua, Mouad; El Ghanmi, Jihad; Karmouni, Tarik; El Khader, Khalid; Koutani, Abdellatif; Attya, Ahmed Iben

    2014-01-01

    Les tumeurs de vessie sont rares avant 40 ans et ne représentent que 1 à 4% de l'ensemble de ces tumeurs. Notre étude s'est intéressée au profil épidémiologique, caractère histologique ainsi que le profil évolutif. Nous avons réalisé une étude retrospective sur une durée de 10 ans entre mars 2004 et mars 2014, nous avons traité 850 patients pour tumeur de vessie dont 36 était âgé de moins de 40 ans. Le diagnostic était posé devant des arguments cliniques, radiologiques et endoscopiques, la cystoscopie avec résection tumorale a précisé la nature histologique et son grading ainsi que le degré d'infiltration. 23 patients avaient une tumeur de vessie non infiltrant le muscle et 13 avaient une tumeur infiltrant le muscle. Le taux de récidive global est de l'ordre de 36,4%, 22% pour la tranche d’âge 20-30 ans et 46% pour la tranche d’âge 31-40 ans. Le risque de progression et de décès est respectivement de 8% et de 6,1%. Il ressort que les tumeurs superficielles ont une meilleure évolution chez les sujets de moins de 30 ans. Les tumeurs infiltrantes sont plus fréquentes et souvent évoluées suggérant un potentiel évolutif particulier. Leur pronostic est fonction du stade tumoral, sans corrélation avec l’âge. PMID:26113886

  14. Pertinence de l'implantation de la filiere granule de bois pour le Quebec

    NASA Astrophysics Data System (ADS)

    Tremblay, Stephan

    Les spécialistes avancent que le marché mondial de l'énergie en forte demande et en offre limitée nécessitera bientôt toutes les formes d'énergie disponibles. Le granulé de bois est une forme de bioénergie principalement utilisée pour le chauffage des bâtiments et pourrait être davantage considéré dans l'offre énergétique du Québec. Comme le Québec est un territoire où il fait froid et donc susceptible de pouvoir se tourner vers cette forme d'énergie, l'objectif de ce mémoire est d'en analyser les avantages. Pour ce faire, nous commencerons par démontrer la croissance des besoins énergétiques sur les plans national et international et dresser un portrait des différentes formes d'énergies consommées au Québec. Puisque la majorité des Québécois chauffent leurs bâtiments à l'hydroélectricité, nous analyserons à travers le plan d'approvisionnement d'Hydro-Québec le portrait de la production et de la consommation de cette forme d'énergie renouvelable. Cela nous permettra de constater le défi face à la gestion de surplus importants, sauf pendant la période hivernale, et ce faisant, l'obligation de la société d'État d'utiliser davantage ses centrales au gaz ou de se tourner vers l'importation de l'électricité. Dans la même lignée, un regard sera porté sur les perspectives d'utilisation de l'hydroélectricité sur les plans de la production d'aluminium, de l'exportation et de l'utilisation dans l'électrification des transports au Québec. Cette analyse se fera dans l'objectif de s'interroger sur la pertinence d'utiliser cette source d'énergie dans le chauffage plutôt que dans des secteurs plus créateurs de richesse. Nous poserons ensuite l'hypothèse que le granulé de bois pourrait être un bon substitut à une autre forme d'énergie utilisée dans le chauffage, soit le mazout. Avant de dresser un portrait de ce combustible fossile, nous ferons celui de la production et de la consommation de granulés sur les plans r

  15. Le modele de Hubbard bidimensionnel a faible couplage: Thermodynamique et phenomenes critiques

    NASA Astrophysics Data System (ADS)

    Roy, Sebastien

    Une etude systematique du modele de Hubbard en deux dimensions a faible couplage a l'aide de la theorie Auto-Coherente a Deux Particules (ACDP) dans le diagramme temperature-dopage-interaction-sauts permet de mettre en evidence l'influence des fluctuations magnetiques sur les proprietes thermodynamiques du systeme electronique sur reseau. Le regime classique renormalise a temperature finie pres du dopage nul est marque par la grandeur de la longueur de correlation de spin comparee a la longueur thermique de de Broglie et est caracterisee par un accroissement drastique de la longueur de correlation de spin. Cette croissance exponentielle a dopage nul marque la presence d'un pic de chaleur specifique en fonction de la temperature a basse temperature. Une temperature de crossover est alors associee a la temperature a laquelle la longueur de correlation de spin est egale a la longueur thermique de de Broglie. C'est a cette temperature caracteristique, ou est observee l'ouverture du pseudogap dans le poids spectral, que se situe le maximum du pic de chaleur specifique. La presence de ce pic a des consequences sur l'evolution du potentiel chimique avec le dopage lorsque l'uniformite thermodynamique est respectee. Les contraintes imposees par les lois de la thermodynamique font en sorte que l'evolution du potentiel chimique avec le dopage est non triviale. On demontre entre autres que le potentiel chimique est proportionnel a la double occupation qui est reliee au moment local. Par ailleurs, une derivation de la fonction de mise a l'echelle de la susceptibilite de spin a frequence nulle au voisinage d'un point critique marque sans equivoque la presence d'un point critique quantique en dopage pour une valeur donnee de l'interaction. Ce point critique, associe a une transition de phase magnetique en fonction du dopage a temperature nulle, induit un comportement non trivial sur les proprietes physiques du systeme a temperature finie. L'approche quantitative ACDP permet de

  16. Quatrième conférence consensuelle sur le diagnostic et le traitement de la démence

    PubMed Central

    Moore, Ainsley; Patterson, Christopher; Lee, Linda; Vedel, Isabelle; Bergman, Howard

    2014-01-01

    Résumé Objectif Revoir les stratégies diagnostiques de la maladie d’Alzheimer, actualiser les recommandations concernant le traitement des symptômes de démence et proposer une approche thérapeutique à la démence d’apparition précoce et d’évolution rapide. Composition du comité Des spécialistes et des délégués de diverses régions du Canada et représentant diverses disciplines pertinentes ont discuté et se sont mis d’accord sur les révisions à apporter aux lignes directrices de 2006. Méthodologie On a eu recours au système GRADE (grading of recommendations, assessment, development, and evaluation) pour évaluer le consensus concernant les recommandations, lequel était défini comme suit : lorsque 80 % ou plus des participants ont voté en faveur de la recommandation. La cote des données probantes est rapportée lorsque cela est possible. Rapport important pour les médecins de famille, malgré les progrès effectués dans les domaines des biomarqueurs liquidiens et de la neuro-imagerie, le diagnostic de démence au Canada demeure fondamentalement clinique. De nouveaux critères cliniques essentiels de diagnostic de la maladie d’Alzheimer en reconnaissent dorénavant les formes moins fréquentes et non amnestiques. La démence précoce, une affection rare, mais importante, devrait inciter les médecins à aiguiller les patients vers un spécialiste ayant accès à des conseillers en génétique. La démence d’évolution rapide, mal définie dans la littérature, faciliterait le dépistage de cette affection rare, mais importante. Les inhibiteurs de la cholinestérase sont maintenant indiqués pour le traitement d’affections autres que la maladie d’Alzheimer. Des lignes directrices concernant l’arrêt du traitement, lesquelles n’existaient pas auparavant, sont également apparues. De nouvelles données probantes sur le recours à la mémantine, aux antidépresseurs et à d’autres agents psychotropes dans le traitement de la

  17. Hypertension during chronic exposure to cold: Comparison between Sprague Dawley (SD) and Long Evans (LE) strains

    SciTech Connect

    Riesselmann, A.; Baron, A.; Fregly, M.J. )

    1991-03-11

    Hypertension accompanies chronic exposure of SD rats to cold (5-6C), including elevation of systolic, diastolic, and mean blood pressures and cardiac hypertrophy. The renin-angiotensin system may play an important role. Earlier studies suggested that the LE strain may have a decrease in angiotensin I converting enzyme (ACE) activity. Measurement of ACE activity in plasmas of SE and LE strains revealed that basal activity of ACE in the plasma of the LE strain was significantly less than that of the SD strain. A second study was carried out in which both strains were exposed to cold for 7 weeks. There were clear differences between strains. Rats of the SD strain had a significant elevation in their blood pressure; a significantly increased urinary output of norepinephrine (NE) and epinephrine (E); and significant increases in weights of heart, kidneys, adrenals, and brown adipose tissue (IBAT) compared to their controls maintained at 26C. In contrast, rats of the LE strain were less responsive to cold in that blood pressure failed to rise as sharply and to attain as high a level; NE and E outputs, as well as weights of heart and IBAT were significantly less than those of rats of the cold-treated SD strain. Thus, the lower ACE activity in plasma of LE strain, as well as a reduced secretion of catecholamines, may protect these rats against the rise of blood pressure characteristically observed when rats of the SD strain are exposed to cold.

  18. LeCDJ1, a chloroplast DnaJ protein, facilitates heat tolerance in transgenic tomatoes.

    PubMed

    Kong, Fanying; Deng, Yongsheng; Wang, Guodong; Wang, Jieru; Liang, Xiaoqing; Meng, Qingwei

    2014-01-01

    The roles of a tomato (Lycopersicon esculentum) chloroplast-targeted DnaJ protein (LeCDJ1) were investigated using wild-type (WT) and sense transgenic tomatoes. The LeCDJ1 expression was upregulated by 38 °C, 42 °C, 45 °C, NaCl, PEG, methyl viologen (MV) and hydrogen peroxide (H2O2), but not by 30 °C and 35 °C. Meanwhile, LeCDJ1 was involved in the response of plants to abscisic acid (ABA). Under heat stress, the sense plants showed better growth, higher chlorophyll content, lower malondialdehyde (MDA) accumulation and relative electrical conductivity (REC), and also less PSII photoinhibition than WT. Interestingly, the sense plants treated with streptomycin (SM), an inhibitor of organellar translation, still showed higher maximum photochemistry efficiency of PSII (Fv/Fm) and D1 protein levels than the SM-untreated WT, suggesting that the protective effect of LeCDJ1 on PSII was, at least partially, independent of D1 protein synthesis. Furthermore, the relatively lower superoxide radical (O2(•-)) and H2O2 levels in the sense plants were considered to be due to the higher ascorbate peroxidase (APX) and superoxide dismutase (SOD) activity, which seemed unlikely dependent on their transcription level. These results indicated that LeCDJ1 overexpression facilitated heat tolerance in transgenic tomatoes. PMID:24148796

  19. Simultaneous Le Fort I, II, and III osteotomies for correction of midface deficiency in Apert disease.

    PubMed

    Dai, Jiewen; Wang, Xudong; Yu, Hongbo; Cheng, Jie; Yuan, Hao; Gui, Haijun; Shen, Shunyao; Shen, Guofang

    2012-09-01

    Le Fort III osteotomy was usually applied to correct midface hypoplasia in Apert syndrome, and various surgical modifications have been developed in recent years. In this article, we reported the simultaneous Le Fort I, II, and III osteotomies for segmental advancement of midface deficiency involving nasal bones, zygoma, inferior orbital rims, and maxilla in an adult Chinese patient with Apert syndrome. To achieve the ideal advancement of different parts of midface simultaneously, we divided the midface into 4 segments, including nasal bone combined with upper portion of maxilla, lower portion of maxilla, and left and right zygoma, with simultaneous Le Fort I, Le Fort II, and Le Fort III osteotomies, and each segment was repositioned as required respectively to obtain ideal facial aesthetics and favorable occlusion. The long-term stability of bony segment advancements also was observed during 7-year follow-up. Compared with segmental distraction osteogenesis or multiple-stage surgery, which mainly applied to younger patients with more severe midface hypoplasia, this single-stage strategy offered a reliable surgical alternative for treating adult patient with midface hypoplasia that should be corrected in different levels.

  20. Leishmaniose viscerale et leucemie aigüe lymphoblastique B: quel est le rapport?

    PubMed Central

    El Youssi, Hind; Touaoussa, Aziz; Bergui, Imane; Bougrine, Nawal; Amrani, Moncef Hassani

    2015-01-01

    L'association leishmaniose viscérale et leucémie aigue a été rarement rapportée dans la littérature, cependant le diagnostic concomitant de ces deux entités n'a jamais été rapporté au Maroc. Le lien entre ces deux pathologies n'a pas encore été établi et le traitement n'a pas encore été codifié. Nous rapportons le cas d'un garçon de 12 ans chez qui une leishmaniose viscérale et une leucémie aigue lymphoblastique type B ont été diagnostiquées simultanément. Malgré l'administration d'un traitement antiparasitaire associé à une chimiothérapie l’évolution était marquée par le décès du patient. PMID:26090011

  1. Amphibians and Reptiles of the state of Nuevo León, Mexico

    PubMed Central

    Lemos-Espinal, Julio A.; Smith, Geoffrey R.; Cruz, Alexander

    2016-01-01

    Abstract We compiled a check list of the herpetofauna of Nuevo León. We documented 132 species (23 amphibians, 109 reptiles), representing 30 families (11 amphibians, 19 reptiles) and 73 genera (17 amphibians, 56 reptiles). Only two species are endemic to Nuevo León. Nuevo León contains a relatively high richness of lizards in the genus Sceloporus. Overlap in the herpetofauna of Nuevo León and states it borders is fairly extensive. Of 130 native species, 102 are considered species of Least Concern in the IUCN red list, four are listed as Vulnerable, five are listed as Near Threatened, and four are listed as Endangered. According to SEMARNAT, 78 species are not of conservation concern, 25 are subject to Special Protection, 27 are Threatened, and none are listed as in Danger of Extinction. Given current threats to the herpetofauna, additional efforts to understand the ecology and status of populations in Nuevo León are needed. PMID:27408562

  2. Amphibians and Reptiles of the state of Nuevo León, Mexico.

    PubMed

    Lemos-Espinal, Julio A; Smith, Geoffrey R; Cruz, Alexander

    2016-01-01

    We compiled a check list of the herpetofauna of Nuevo León. We documented 132 species (23 amphibians, 109 reptiles), representing 30 families (11 amphibians, 19 reptiles) and 73 genera (17 amphibians, 56 reptiles). Only two species are endemic to Nuevo León. Nuevo León contains a relatively high richness of lizards in the genus Sceloporus. Overlap in the herpetofauna of Nuevo León and states it borders is fairly extensive. Of 130 native species, 102 are considered species of Least Concern in the IUCN red list, four are listed as Vulnerable, five are listed as Near Threatened, and four are listed as Endangered. According to SEMARNAT, 78 species are not of conservation concern, 25 are subject to Special Protection, 27 are Threatened, and none are listed as in Danger of Extinction. Given current threats to the herpetofauna, additional efforts to understand the ecology and status of populations in Nuevo León are needed. PMID:27408562

  3. LeCDJ1, a chloroplast DnaJ protein, facilitates heat tolerance in transgenic tomatoes.

    PubMed

    Kong, Fanying; Deng, Yongsheng; Wang, Guodong; Wang, Jieru; Liang, Xiaoqing; Meng, Qingwei

    2014-01-01

    The roles of a tomato (Lycopersicon esculentum) chloroplast-targeted DnaJ protein (LeCDJ1) were investigated using wild-type (WT) and sense transgenic tomatoes. The LeCDJ1 expression was upregulated by 38 °C, 42 °C, 45 °C, NaCl, PEG, methyl viologen (MV) and hydrogen peroxide (H2O2), but not by 30 °C and 35 °C. Meanwhile, LeCDJ1 was involved in the response of plants to abscisic acid (ABA). Under heat stress, the sense plants showed better growth, higher chlorophyll content, lower malondialdehyde (MDA) accumulation and relative electrical conductivity (REC), and also less PSII photoinhibition than WT. Interestingly, the sense plants treated with streptomycin (SM), an inhibitor of organellar translation, still showed higher maximum photochemistry efficiency of PSII (Fv/Fm) and D1 protein levels than the SM-untreated WT, suggesting that the protective effect of LeCDJ1 on PSII was, at least partially, independent of D1 protein synthesis. Furthermore, the relatively lower superoxide radical (O2(•-)) and H2O2 levels in the sense plants were considered to be due to the higher ascorbate peroxidase (APX) and superoxide dismutase (SOD) activity, which seemed unlikely dependent on their transcription level. These results indicated that LeCDJ1 overexpression facilitated heat tolerance in transgenic tomatoes.

  4. Le nœud ileosigmoidien: à propos de 2 cas

    PubMed Central

    Bensardi, Fatimazahra; Elhattabi, Khalid; Fadil, Abdelaziz; Benissa, Nadia; Lefriyekh, Rachid; Khaiz, Driss; Berrada, Saad; Zerouali, Ouariti Najib

    2012-01-01

    Le nœud iléosigmoïdien ou l’ileosigmoid knot (ISK), est une entité clinique exceptionnelle, c’est une urgence chirurgicale caractérisée par une strangulation du grêle en formant un nœud autour de la base du colon sigmoïde avec risque de nécrose rapide du grêle et du colon. Nous rapportons deux cas dans le service des urgences chirurgicales viscérales du CHU Ibn Rochd de Casablanca ; chez lesquels le diagnostic d’ISK n’a été posé qu’en peropératoire. A travers ces 2 cas et une revue de la littérature nous allons définir les aspects diagnostiques, thérapeutiques et pronostiques de cette entité clinique rare. PMID:22593779

  5. Le conflit fémoro-acétabulaire et la coxarthrose

    PubMed Central

    Zhang, Charlie; Li, Linda; Forster, Bruce B.; Kopec, Jacek A.; Ratzlaff, Charles; Halai, Lalji; Cibere, Jolanda; Esdaile, John M.

    2015-01-01

    Objectif Expliquer la présentation clinique, les observations à l’examen physique, les critères diagnostiques et les options de prise en charge du conflit fémoroacétabulaire (CFA). Sources des données Une recherche documentaire a été effectuée dans PubMed pour trouver des articles pertinents sur la pathogenèse, le diagnostic, le traitement et le pronostic du CFA. Message principal Depuis les dernières années, on reconnaît de plus en plus que le CFA est un précurseur potentiel et une étiologie importante des douleurs à la hanche dans la population adulte et de la coxarthrose idiopathique plus tard dans la vie. Le conflit fémoro-acétabulaire désigne un ensemble d’anomalies morphologiques osseuses de l’articulation de la hanche qui se traduit par un contact anormal durant le mouvement. Le CFA par effet came concerne une proéminence osseuse non sphérique du col fémoral proximal ou de la jonction tête-col. Le CFM par effet tenaille désigne une couverture acétabulaire excessive par-dessus la tête du fémur, qui peut se produire en raison de diverses variantes morphologiques. Les patients qui ont un CFA présentent une douleur inguinale antérieure chronique, profonde ou lancinante, le plus souvent en position assise, durant ou après une activité. Les patients peuvent aussi ressentir des douleurs occasionnelles aiguës durant l’activité. Il faut procéder à une anamnèse approfondie portant notamment sur l’incidence de traumatismes ou la fréquence de l’exercice. Il faut aussi faire un examen physique complet des hanches, de la région lombaire et de l’abdomen pour évaluer d’autres causes de douleurs inguinales antérieures. Le diagnostic de CFA est confirmé par radiographie. Le conflit fémoro-acétabulaire peut être pris en charge selon une approche conservatrice comportant du repos, la modification des activités, des médicaments et de la physiothérapie ou encore être traité par intervention chirurgicale. Conclusion

  6. Role of Le Fort type I osteotomy approach in juvenile nasopharyngeal angiofibroma.

    PubMed

    Singh, R; Hazarika, P; Nayak, D R; Balakrishnan, R; Pillai, S; Hazarika, M

    2011-11-01

    Le Fort type I osteotomy is a fracture that extends from the pyriform aperture to each of the pterygoid plates, resulting in the detachment of the upper jaw from the cranial base. A retrospective study was conducted on 12 patients with juvenile nasopharyngeal angiofibroma (JNA) who underwent the Le Fort type I approach. Preoperatively, all cases were investigated with computed tomographic scans with contrast and angiography with embolisation. This paper highlights the surgical technique, results and treatment morbidity. The average age of the patients was 21 years, average duration of surgery was 3.2h and average blood loss was 550 ml. All cases had significant symptomatic improvement postoperatively. At 1 year follow up, the authors encountered dental malocclusion in one case and no recurrence of JNA. The Le Fort I osteotomy approach is an excellent approach for the excision of JNA because it allows good surgical exposure, better haemostasis, is cosmetically more acceptable and has a very low morbidity.

  7. Oncoplastie avec conservation mammaire dans le traitement du cancer du sein: à propos de 16 cas

    PubMed Central

    Bouzoubaa, Wail; Laadioui, Meryam; Jayi, Sofia; Alaoui, Fatime Zahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2015-01-01

    Le cancer du sein est actuellement le cancer le plus fréquent chez la femme, et pose un véritable problème diagnostique et thérapeutique. Le dépistage des lésions à un stade de plus en plus précoce, a permis une extension des indications du traitement conservateur radiochirurgical, qui était initialement limitées aux tumeurs de moins de 3 cm, unifocales, non inflammatoires. Par ailleurs, l'utilisation de traitements préopératoires permet d’étendre les indications du traitement conservateur à des tumeurs plus volumineuses. Parallèlement à cette extension des indications de conservation mammaire, on a observé le développement de nouvelles approches thérapeutiques notamment la chirurgie oncoplastique, technique du ganglion sentinelle et chirurgie stéréotaxique, dont les résultats initiaux sont très encouragent. A travers cette étude réalisée dans le service de gynécologie et obstétrique II du CHU HASSAN II de FES au MAROC, après l'analyse rétrospective de 16 patientes traitées par traitement conservateur et oncoplastie, nous avons voulus montrer notre aptitude a réalisé ses techniques chirurgicales et a bien prendre en charge ces patientes, mais aussi évaluer ces techniques en termes de résultat carcinologique et de résultat esthétique, aussi en terme de survie globale, survie sans métastase et en termes de récidive locale entre les plasties mammaires et les traitements usuels: mastectomie et traitement conservateur classique. PMID:26430477

  8. Infection par le virus de l’hépatite E durant la grossesse

    PubMed Central

    Chaudhry, Shahnaz A.; Verma, Natasha; Koren, Gideon

    2015-01-01

    Résumé Question Plusieurs de mes patientes sont originaires de l’Asie du Sud-Est où le virus de l’hépatite E est assez commun. Quelles précautions puis-je leur suggérer de prendre avant de voyager dans cette région et quels sont les risques d’une infection par le VHE durant la grossesse? Réponse L’hépatite E est un pathogène présent dans l’eau qui se transmet par voie oro-fécale. Afin de réduire le risque de contracter le VHE lors de voyages dans des régions endémiques, il est important de maintenir des pratiques d’hygiène telles que se laver les mains avec de l’eau potable, particulièrement avant de manipuler de la nourriture, éviter de boire de l’eau ou d’utiliser des glaçons de pureté inconnue et ne pas manger de fruits ou de légumes non pelés. Actuellement, il n’existe aucun vaccin disponible au Canada pour le VHE. Une infection à l’hépatite E durant la grossesse, surtout durant le troisième trimestre, se caractérise par une infection plus sévère qui se transforme parfois en hépatite fulminante, augmentant ainsi les risques de mortalité et de morbidité maternelles et fœtales.

  9. le de la radiothérapie dans le traitement de l'améloblastome: à propos de deux cas

    PubMed Central

    El Mazghi, Abderrahman; Bouhafa, Touria; El Kacemi, Hanan; Loukili, Kaoutar; Chbani, Laila; Kebdani, Taieb; Hassouni, Khalid

    2014-01-01

    L'améloblastome est une tumeur odontogène bénigne mais à pouvoir agressif et invasif local important. C'est une tumeur rare, elle représente 1% des tumeurs des maxillaires. Lele de la radiothérapie dans son traitement est actuellement démontré pour les tumeurs inopérables. Nous rapportons 2 cas d'améloblastomes mandibulaires chez deux patients qui ont bénéficié d'une radiothérapie externe à la dose de 60 Gy. L’évolution a été marquée par une rémission complète de la maladie dans les deux cas avec un recul de 2 et 5 ans. PMID:25722762

  10. A brief account of the life of René Le Fort.

    PubMed

    Gartshore, Laura

    2010-04-01

    In 1901, René Le Fort conducted some of the most infamous experiments known to maxillofacial surgery. He was an interesting and highly accomplished man with experience in many fields of surgery. We continue to use much of his research today despite many advances in medicine, yet we know little about the man himself.The aim of this short paper is to introduce you to René Le Fort and to describe the highlights of his experiments, which gave rise to a system of classifying facial fractures.

  11. Conductivite dans le modele de Hubbard bi-dimensionnel a faible couplage

    NASA Astrophysics Data System (ADS)

    Bergeron, Dominic

    Le modele de Hubbard bi-dimensionnel (2D) est souvent considere comme le modele minimal pour les supraconducteurs a haute temperature critique a base d'oxyde de cuivre (SCHT). Sur un reseau carre, ce modele possede les phases qui sont communes a tous les SCHT, la phase antiferromagnetique, la phase supraconductrice et la phase dite du pseudogap. Il n'a pas de solution exacte, toutefois, plusieurs methodes approximatives permettent d'etudier ses proprietes de facon numerique. Les proprietes optiques et de transport sont bien connues dans les SCHT et sont donc de bonne candidates pour valider un modele theorique et aider a comprendre mieux la physique de ces materiaux. La presente these porte sur le calcul de ces proprietes pour le modele de Hubbard 2D a couplage faible ou intermediaire. La methode de calcul utilisee est l'approche auto-coherente a deux particules (ACDP), qui est non-perturbative et inclue l'effet des fluctuations de spin et de charge a toutes les longueurs d'onde. La derivation complete de l'expression de la conductivite dans l'approche ACDP est presentee. Cette expression contient ce qu'on appelle les corrections de vertex, qui tiennent compte des correlations entre quasi-particules. Pour rendre possible le calcul numerique de ces corrections, des algorithmes utilisant, entre autres, des transformees de Fourier rapides et des splines cubiques sont developpes. Les calculs sont faits pour le reseau carre avec sauts aux plus proches voisins autour du point critique antiferromagnetique. Aux dopages plus faibles que le point critique, la conductivite optique presente une bosse dans l'infrarouge moyen a basse temperature, tel qu'observe dans plusieurs SCHT. Dans la resistivite en fonction de la temperature, on trouve un comportement isolant dans le pseudogap lorsque les corrections de vertex sont negligees et metallique lorsqu'elles sont prises en compte. Pres du point critique, la resistivite est lineaire en T a basse temperature et devient

  12. Le glaucome congénitale et la neurofibromatose type 1

    PubMed Central

    Tzili, Nazih; El Orch, Hamza; Bencherifa, Fatiha; Chefchaouni, Mohammed Charif; Abdallah, El Hassan; Berraho, Amina

    2015-01-01

    Le glaucome congénital constitue une complication ophtalmologique dans la neurofibromatose type 1 ou maladie de von Recklinghausen. Nous rapportons un cas de glaucome congénitale dans le cadre d'une neurofibromatose de type 1, à travers lequel on va discuter les mécanismes étiopathogénique, les difficultés thérapeutiques et les facteurs pronostiques du glaucome congénital au cours la maladie de von Recklinghausen avec revue de la littérature. PMID:26405492

  13. The Center for Learning Technologies in Urban Schools (LeTUS) Program[R]. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    The "LeTUS" program is a three-year, project-based, technology-integrated middle school science curriculum for grades 6-8. The "LeTUS" program is composed of multiple units, each lasting between eight and ten weeks. Topics include global warming, water and air quality, force and motion, communicable diseases, and ecological systems. The units are…

  14. 40Ar/39Ar Age Dating of Two Chondrules from the Bjurböle (L/LL4) Chondrite

    NASA Astrophysics Data System (ADS)

    Park, J.; Lindsay, F. N.; Turrin, B. D.; Herzog, G. F.; Delaney, J. S.; Swisher, C. C.

    2016-08-01

    We present detailed 40Ar/39Ar results for two Bjurböle chondrules. Younger Ar/Ar step ages for one Bjurböle chondrule suggest that the analysis of single chondrules can yield more accurate meteorite ages than are obtainable from bulk samples.

  15. Curiethérapie dans le traitement palliatif du cancer de l’œsophage

    PubMed Central

    Toulba, Ahmedou; Bakkali, Hanae; Boutayeb, Salwa; Kebdani, Tayeb; Ahid, Samir; Benjaafar, Noureddine

    2015-01-01

    Les patients atteints du cancer de l’œsophage ont souvent une maladie localement avancée, la dysphagie est le symptôme majeur chez la plupart de ces patients, plusieurs modalités thérapeutiques ont été utilisées pour améliorer cette dysphagie. Le but de ce travail est d’étudier l'efficacité et la tolérance de la curiethérapie haut débit de dose (HDR) endo-luminale dans le traitement palliatif des cancers de l’œsophage inopérable. Sur une période de 15 ans, l’étude a inclus les patients atteints de cancer de l’œsophage inopérable et/ou métastatique avec une dysphagie, sans extension à l'hypopharynx ou a la trachée et qui ont bénéficié d'une curiethérapie HDR avec ou sans radiothérapie externe à visée palliative. Au total 46 patients ont été inclus dans l’étude, 58,7% étaient des hommes, 42,2% avaient une dysphagie grade 2 et 37,8% étaient aphagiques, 78,6% des patients étaient performance satus PS 2, l'amaigrissement à été trouvé chez 81,4%, la localisation de la tumeur était surtout au niveau du tiers moyen et inférieur dans 97,8%, la hauteur médiane de la tumeur était de 7 cm (5,5-9), le carcinome épidermoïde était le type histologique le plus fréquent chez 31 patients (70,5%). Après un médiane de suivi de 5 mois, l'amélioration de la dysphagie a été retrouvée chez 76% des malades (p1]. L′incidence la plus élevée est observée dans certains pays notamment en Asie et en Afrique, et l′incidence dans les pays développés occidentaux est en augmentation [2]. Selon le registre du cancer de Rabat 2006-2008, le cancer de l’œsophage est rare et constitue 1,5% de tous les cancers chez l'homme [3]. Le taux de survie globale à 5 ans est de 8%, avec 80% des décès liés à l’évolution locale de la maladie [4]. Pour la minorité des patients avec une maladie localisée, le traitement par radiochimiothérapie concomitante avec ou sans chirurgie permet une amélioration de la survie [5]. Plus de 50

  16. Cutaneous leishmaniasis due to Leishmania chagasi/Le. infantum in an endemic area of Guarico State, Venezuela.

    PubMed

    De Lima, H; Rodríguez, N; Feliciangeli, M D; Barrios, M A; Sosa, A; Agrela, I; Sánchez, E; Lopez, O

    2009-07-01

    This study reports cutaneous leishmaniasis (CL) caused by Leishmania chagasi/Le. infantum in Venezuela, with some atypical characteristics. Out of 63 cases of CL in the suburbs of Altagracia de Orituco, Guarico State, Venezuela, 30 presented clinical, parasitological, immunological and epidemiological features different from those of the classical CL known in the country. The initial lesion was small and nodular, which, if not treated, might progress to a superficial ulcer. No secondary infection was observed. The identification of the isolates was carried out by molecular techniques. Twelve species of phlebotomine sandflies were caught, the most abundant being Lutzomyia evansi and Lu. longipalpis s.l., known vectors of Le. chagasi/Le. infantum. The existence of Le. chagasi/Le. infantum and its vectors in an endemic area of CL has implications and we suggest that epidemiological studies should be carried out to obtain a clearer picture of the extent of this CL form in Venezuela.

  17. The Adverse Effects of Le Chatelier's Principle on Teacher Understanding of Chemical Equilibrium

    ERIC Educational Resources Information Center

    Cheung, Derek

    2009-01-01

    Although the scientific inadequacy of Le Chatelier's principle has long been documented in the literature, the principle is still treated as a central concept of chemical equilibrium by textbook writers and teachers in many countries. In the past, researchers' interest has focused on student misconceptions about chemical equilibrium and has…

  18. Students' and Teachers' Misapplication of Le Chatelier's Principle: Implications for the Teaching of Chemical Equilibrium.

    ERIC Educational Resources Information Center

    Quilez-Pardo, Juan; Solaz-Portoles, Joan Josep

    1995-01-01

    Study of strategies and procedures of 170 students and 40 teachers when solving chemical equilibrium problems found misconceptions emerging through: misapplication of Le Chatelier's Principle, use of rote-learning recall, incorrect control of variables, limited use of chemical equilibrium law, lack of mastery of chemical equilibrium principles,…

  19. Through Ecofeminist Eyes: Le Guin's "The Ones Who Walk Away from Omelas"

    ERIC Educational Resources Information Center

    Bennett, Barbara

    2005-01-01

    Barbara Bennett explains the tenets behind ecofeminism and why it is a useful and appropriate method of literary analysis for today's world. By applying the theory to Le Guin's story, she helps her students relate the issues of ecofeminism to their American lifestyle.

  20. Tested Demonstrations: Thermodynamic Changes, Kinetics, Equilibrium, and LeChatelier's Principle.

    ERIC Educational Resources Information Center

    Gilbert, George L., Ed.

    1984-01-01

    Procedures for demonstrating thermodynamic changes, kinetics and reaction mechanisms, equilibrium, and LeChatelier's principle are presented. The only materials needed for these demonstrations are beakers, water, assorted wooden blocks of varying thickness, assorted rubber tubing, and a sponge. The concepts illustrated in each demonstration are…

  1. Selected data for stream subbasins in the Le Sueur River basin, south-central Minnesota

    USGS Publications Warehouse

    Lorenz, D.L.; Payne, G.A.

    1990-01-01

    This report presents selected data that describe the characteristics of stream basins upstream from selected points on streams in the Le Sueur River basin. The points on the streams include outlets of subbasins of about five square miles, sewage treatment plant outlets, and U.S. Geological Survey streamflow-gaging stations in the basin.

  2. Delayed progressive haematoma after Le Fort I osteotomy: A possible severe complication in orthognatic surgery.

    PubMed

    Bertossi, Dario; Malchiodi, Luciano; Shideh, Ehsani; Albanese, Massimo; Portelli, Marco; Lucchese, Alessandra; Carinci, Francesco; Nocini, Pierfrancesco

    2012-12-01

    Although the Le Fort I osteotomy is a safe surgical technique, many complications have been reported. We present a case of an extended cervico-facial haematoma due to delayed bleeding from the terminal branches of the maxillary artery after orthognatic surgery. A 23-year-old man was referred to our observation for the surgical correction of a class III asymmetric malocclusion. The patient underwent a Le Fort I osteotomy, with impaction of the maxilla, associated with an Epker mandibular bilateral sagittal split osteotomy, with maxillary advancement and rigid internal fixation of the mandible with four miniplates and another four for the upper maxilla as well. The first post-surgery day, the patient developed a gradual dispnea together with neck swelling. By second postoperative day, the patient's general condition improved with a progressive normalization of laboratory tests values. The Computerised Axial Tomography (CAT) scan confirmed a decrease in the parapharyngeal thickening. Total recovery was achieved within two months, the final clinical check showed a healthy appearance with good occlusion. An increased knowledge of the basic biology of the Le Fort I osteotomy, the development of instruments specially designed for the Le Fort I procedure and the use of hypotensive anaesthesia could reduce the morbidity and duration of this procedure.

  3. Life-threatening haemorrhage after 750 Le Fort I osteotomies and 376 SARPE procedures.

    PubMed

    Politis, C

    2012-06-01

    This study assessed the incidence, presenting symptoms, diagnosis, and management of patients with life-threatening postoperative haemorrhage after total Le Fort I osteotomy and surgically assisted rapid palatal expansion (SARPE). The medical records of 750 consecutive Le Fort I osteotomies and 376 consecutive SARPEs, both of which involved pterygomaxillary separation with a curved osteotome and a mallet, were analysed prospectively. Two cases of life-threatening haemorrhage were observed in the Le Fort I osteotomy group, both initiated on postoperative day 7. Anterior and posterior nasal packing were successful in one patient; the other required two embolizations for bleeding control (incidence of life-threatening postoperative haemorrhage: 2/750; confidence interval: 0.03-0.96%). In the SARPE group, one brisk epistaxis on the first postoperative day was controlled with anterior and posterior nasal packing under general anaesthesia. This haemorrhage was not considered life threatening (incidence of life-threatening postoperative haemorrhage: 0/376; confidence interval: 0-0.98%). In no case could the source of bleeding be established during re-explorative surgery or during diagnostic arteriography. The authors conclude that life-threatening haemorrhage is an exceptional finding after Le Fort I osteotomy; the observed incidence was 2/750, and life-threatening haemorrhage was not observed after SARPE in this series, despite the use of identical pterygomaxillary separation.

  4. LE[superscript 3]AD Academy Builds Professionalism in Vocational Students

    ERIC Educational Resources Information Center

    Hall, Candace

    2012-01-01

    Principal David Wheeler of Southeastern Regional Vocational-Technical High School founded LE[superscript 3]AD Academy--an innovative program that gives students the opportunity to build and run their own town in teams and with guidance from teachers. The program started in the spring of 2011, and it is innovative in many ways. The students' main…

  5. Une fistule recto-vaginale rentrant dans le cadre d'un syndrome de Currarino

    PubMed Central

    Idrissi, Mounia Lakhdar; Babakhoya, Abdeladim; Bouabdellah, Youssef; Hida, Mostapha

    2011-01-01

    Le syndrome de Currarino (SC) est défini par une triade rassemblant une malformation ano-rectale, une agénésie sacrée et une tumeur pré-sacrée. Nous rapportons le cas d'une fille de 4 ans et demi ayant été admise en consultation de gastro-entérologie pédiatrique pour constipation avec issue de selle à travers un orifice vulvaire. La radiographie du rachis avait montré une agénésie sacrée. Le fistulo-scanner a mis en évidence une fistule recto-vaginale et l'IRM pelvienne a confirmé l'agénésie sacrée et a retrouvé une méningocèle antérieure. La découverte d'une malformation ano-rectale doit faire chercher une autre anomalie de la triade de Currarino. Cette affection, rare, nécessite une prise en charge médico-chirurgicale assez complexe. PMID:22384297

  6. Le syndrome de Stewart-Treves compliquant un lymphœdème chronique idiopathique

    PubMed Central

    Safini, Fatima; Naim, Asmaa; Bouchbika, Zineb; Benchakroun, Nadia; Jouhadi, Hassan; Tawfiq, Nezha; Sahraoui, Souha; Benider, Abdellatif

    2014-01-01

    Le syndrome de Stewart-Treves (SST) est une entité rare, correspondant à un angiosarcome cutané compliquant un lymphoedème chronique. Il est de mauvais pronostic. Stewart et Treves ont rapportés en 1948, les premiers cas d'angiosarcome secondaire à un traitement du cancer du sein. Ce terme s'est généralisé pour regrouper l'ensemble des cas de lymphangiosarcome sur lymphoedème d'origine congénital héréditaire ou non héréditaire, post-traumatique ou post-infectieux. Le SST sur un lymphoedème idiopathique reste exceptionnel. Nous rapportons le cas rare d'une patiente présentant un lymphoedème chronique primitif idiopathique des quatre membres évoluant depuis l'adolescence et qui a développé un SST du membre supérieur droit. Elle a subi une amputation à mi- bras vu le caractère très évolué de la tumeur PMID:25883738

  7. The Ammonia Synthesis Reaction: An Exception to the Le Chatelier Principle and Effects of Nonideality

    ERIC Educational Resources Information Center

    Uline, Mark J.; Corti, David S.

    2006-01-01

    Le Chatelier's principle states that the further addition of a particular component will cause the reaction to shift in the direction that reduces the total number of moles of the system. However, the addition of one reactant [N[subscript 2

  8. "Ambivalence to Technology in Jeunet's" Le Fabuleux Destin d'Amelie Poulain

    ERIC Educational Resources Information Center

    Moore, Rick Clifton

    2006-01-01

    Although at one level Jean-Pierre Jeunets "Le Fabuleux Destin d'Amelie Poulain" is a sweet, attractive film about a young Parisian doing good deeds, it also offers a compelling analysis of the role of technology in our modern lives. The film paints a world where machines and a mechanistic worldview are appealing because humans have a desire to…

  9. From Interactive Open Learner Modelling to Intelligent Mentoring: STyLE-OLM and Beyond

    ERIC Educational Resources Information Center

    Dimitrova, Vania; Brna, Paul

    2016-01-01

    STyLE-OLM (Dimitrova 2003 "International Journal of Artificial Intelligence in Education," 13, 35-78) presented a framework for interactive open learner modelling which entails the development of the means by which learners can "inspect," "discuss" and "alter" the learner model that has been jointly…

  10. The Potassium-Argon Laser Experiment (KarLE): In Situ Geochronology for Mars and Beyond

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.

    2014-01-01

    The search for life in the solar system depends upon discovering the right moments in planetary evolution: when habitable environments existed, when they declined, and when geologic processes operated to preserve traces of life after death. However, an incomplete knowledge of absolute Martian geochronology limits our ability to understand the timing of Martian evolutionary milestones, major climate changes, and stratigraphic epochs [1, 2]. Absolute dating relates these habitability markers to planetarywide geologic, atmospheric, and climate history places, and ties their occurrence to the history of the solar system, especially the Earth-Moon system and the timescale of evolution of life on Earth. KArLE is being developed to anchor the relative timeline of geological events to an absolute chronology that puts Mars into a wider solar system context. KArLE makes its measurements on rock samples that can be obtained by landers or rovers and inserted into a small, mechanically simple chamber. KArLE interrogates the samples using laser-induced breakdown spectrocopy (LIBS), mass spectrometry, and optical imaging. The KArLE experiment is flexible enough to accommodate any partner providing these instrument components, a creative approach that extends the ability of mission payloads to accomplish an additional highly-desirable science measurement for low cost and risk and minimal extra hardware.

  11. Developement of the Potassium-Argon Laser Experiment (KArLE) for In Situ Geochronology

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.

    2012-01-01

    Absolute dating of planetary samples is an essential tool to establish the chronology of geological events, including crystallization history, magmatic evolution, and alteration. Thus far, radiometric geochronology of planetary samples has only been accomplishable in terrestrial laboratories on samples from dedicated sample return missions and meteorites. In situ instruments to measure rock ages have been proposed, but none have yet reached TRL 6, because isotopic measurements with sufficient resolution are challenging. We have begun work under the NASA Planetary Instrument Definition and Development Program (PIDDP) to develop the Potassium (K) - Argon Laser Experiment (KArLE), a novel combination of several flight-proven components that will enable accurate KAr isochron dating of planetary rocks. KArLE will ablate a rock sample, measure the K in the plasma state using laser-induced breakdown spectroscopy (LIBS), measure the liberated Ar using quadrupole mass spectrometry (QMS), and relate the two by measuring the volume of the abated pit using a optical methods such as a vertical scanning interferometer (VSI). Our preliminary work indicates that the KArLE instrument will be capable of determining the age of several kinds of planetary samples to 100 Myr, sufficient to address a wide range of geochronology problems in planetary science. Additional benefits derive from the fact that each KArLE component achieves analyses common to most planetary surface missions.

  12. Geomorphic evolution of the Le Sueur River, Minnesota, USA, and implications for current sediment loading

    USGS Publications Warehouse

    Gran, K.B.; Belmont, P.; Day, S.S.; Jennings, C.; Johnson, Aaron H.; Perg, L.; Wilcock, P.R.

    2009-01-01

    There is clear evidence that the Minnesota River is the major sediment source for Lake Pepin and that the Le Sueur River is a major source to the Minnesota River. Turbidity levels are high enough to require management actions. We take advantage of the well-constrained Holocene history of the Le Sueur basin and use a combination of remote sensing, fi eld, and stream gauge observations to constrain the contributions of different sediment sources to the Le Sueur River. Understanding the type, location, and magnitude of sediment sources is essential for unraveling the Holocene development of the basin as well as for guiding management decisions about investments to reduce sediment loads. Rapid base-level fall at the outlet of the Le Sueur River 11,500 yr B.P. triggered up to 70 m of channel incision at the mouth. Slope-area analyses of river longitudinal profi les show that knickpoints have migrated 30-35 km upstream on all three major branches of the river, eroding 1.2-2.6 ?? 109 Mg of sediment from the lower valleys in the process. The knick zones separate the basin into an upper watershed, receiving sediment primarily from uplands and streambanks, and a lower, incised zone, which receives additional sediment from high bluffs and ravines. Stream gauges installed above and below knick zones show dramatic increases in sediment loading above that expected from increases in drainage area, indicating substantial inputs from bluffs and ravines.

  13. Transient simulation of LOX/LH2 rocket engine, LE-7

    NASA Astrophysics Data System (ADS)

    Kanmuri, Akio; Wakamatsu, Yoshio; Kanda, Takeshi; Torii, Yoshihiro; Nagao, Ryuuji; Kitakura, Kazuhisa; Okada, Masashi; Imoto, Takayuki; Saito, Takashi; Hasegawa, Keiichi

    A start transient simulation calculation program was developed for the LE-7 LOX/LH2 rocket engine based on the quasi-steady model. Comparisons between simulation and test results are reported which show that simulation improvements and engine parameter adjustments are required. A brief description of the engine system is given.

  14. 13. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 STAIR DETAIL, SECOND FLOOR LEVEL (INSPECTION OF STAIR REVEALS PRESENCE OF A STRING OPPOSITE BANNISTER ORIGINALLY). - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  15. 12. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 CLOSE-UP DETAIL OF CORNER FIREPLACE. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  16. 11. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 SOUTHWEST ROOM SHOWING ORIGINAL CORNER FIREPLACE, OPENING BEHIND BAR. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  17. 9. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 CLOSE-UP OF SMALL FRONT FIREPLACE, SOUTHWEST ROOM. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  18. 8. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 REEDING DETAIL OF MANTEL IN NORTHEAST PARLOR. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  19. 6. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 NORTHWEST ROOM SHOWING COOK FIREPLACE, ORIGINAL MANTEL, CRANE AND OPENING FOR BAKE OVEN. - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  20. 5. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Pierre LeBoutillier and Trusten M. Baldwin, Photographers, April, 1960 INTERIOR DETAIL, NORTHEAST AND SOUTHEAST PARLORS, ORIGINAL MANTEL (LEFT - RADIATOR COVERED). - King of Prussia Inn, U.S. Route 202 (Upper Merion Township), King of Prussia, Montgomery County, PA

  1. Molecular and cellular characterization of the tomato pollen profilin, LePro1

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Profilin is an actin-binding protein involved in the dynamic turnover and restructuring of the actin cytoskeleton in all eukaryotic cells. We previously cloned a profilin gene, designated as LePro1 from tomato pollen. To investigate its biological role, in the present study, We investigated the tem...

  2. Developing Communication Skills in Deaf Primary School Pupils: Introducing and Evaluating the SmiLE Approach

    ERIC Educational Resources Information Center

    Alton, Sherryn; Herman, Rosalind; Pring, Tim

    2011-01-01

    Many profoundly deaf signers have difficulty communicating with hearing people. This article describes a therapy called "Strategies and Measurable Interaction in Live English" (smiLE; Schamroth and Threadgill, 2007a), an approach used to teach deaf children skills to become successful communicators in real-life situations. This study evaluates the…

  3. Le chondrosarcome naso-sinusien: à propos de deux cas et revue de la literature

    PubMed Central

    Touati, Mohamed Mliha; Chihani, Mehdi; Darouassi, Youssef; Lakouichmi, Mohammed; Tourabi, Khalid; Bouaity, Brahim; Ammar, Haddou

    2014-01-01

    Le chondrosarcome est une tumeur maligne très destructrice d'origine cartilagineuse, osseuse et mesnchymateuse. La localisation au niveau de la tête et cou est rare et le siège naso sinusien est encore plus rare. Nous rapportons deux observations de chondrosarcome du sinus maxillaire droit et sphéno ethmoïdale. Le but de notre travail est de montrer à travers ces deux cas cliniques, l'intérêt de la tomodensitométrie et de la résonance magnétique dans la présemption diagnostique en corrélation avec la clinique et l'endoscopie,de discuter le choix de la voix et la technique d'abord chirurgical et la surveillance post opératoire. A travers ces deux observations nous soulignerons les difficultés que pose cette tumeur à l'anatomopathologiste pour différencier entre chondrome et chondrosarcome. PMID:25810801

  4. Reflections on "Petit Battement sur le Cou de Pied": Is It Still Relevant?

    ERIC Educational Resources Information Center

    Paskevska, Anna

    2007-01-01

    This article presents multiple perspectives of "petit battement sur le cou de pied". These perspectives include historical, biomechanical, and pedagogic points of view. The article offers useful information for ballet specialists and applied research studies aimed at ballet pedagogy. (Contains 2 tables and 5 figures.)

  5. Tuning LeSPL-CNR expression by SlymiR157 affects tomato fruit ripening.

    PubMed

    Chen, Weiwei; Kong, Junhua; Lai, Tongfei; Manning, Kenneth; Wu, Chaoqun; Wang, Ying; Qin, Cheng; Li, Bin; Yu, Zhiming; Zhang, Xian; He, Meiling; Zhang, Pengcheng; Gu, Mei; Yang, Xin; Mahammed, Atef; Li, Chunyang; Osman, Toba; Shi, Nongnong; Wang, Huizhong; Jackson, Stephen; Liu, Yule; Gallusci, Philippe; Hong, Yiguo

    2015-01-19

    In plants, microRNAs (miRNAs) play essential roles in growth, development, yield, stress response and interactions with pathogens. However no miRNA has been experimentally documented to be functionally involved in fruit ripening although many miRNAs have been profiled in fruits. Here we show that SlymiR157 and SlymiR156 differentially modulate ripening and softening in tomato (Solanum lycopersicum). SlymiR157 is expressed and developmentally regulated in normal tomato fruits and in those of the Colourless non-ripening (Cnr) epimutant. It regulates expression of the key ripening gene LeSPL-CNR in a likely dose-dependent manner through miRNA-induced mRNA degradation and translation repression. Viral delivery of either pre-SlymiR157 or mature SlymiR157 results in delayed ripening. Furthermore, qRT-PCR profiling of key ripening regulatory genes indicates that the SlymiR157-target LeSPL-CNR may affect expression of LeMADS-RIN, LeHB1, SlAP2a and SlTAGL1. However SlymiR156 does not affect the onset of ripening, but it impacts fruit softening after the red ripe stage. Our findings reveal that working together with a ripening network of transcription factors, SlymiR157 and SlymiR156 form a critical additional layer of regulatory control over the fruit ripening process in tomato.

  6. List processing software for the LeCroy 1821 Segment Manager Interface

    SciTech Connect

    Dorries, T.; Moore, C.; Pordes, R.

    1987-05-01

    Many experiments at Fermilab now include some FASTBUS electronics in their data readout. The software reported in this paper provides general support for the LeCroy 1821 interface. The list processing device drivers allow FASTBUS data to be read out efficiently into the Fermilab Computing Department supported data acquisition systems.

  7. Habitat and nesting of Le Conte's Sparrows in the northern tallgrass prairie

    USGS Publications Warehouse

    Winter, M.; Shaffer, J.A.; Johnson, D.H.; Donovan, T.M.; Svedarsky, W.D.; Jones, P.W.; Euliss, B.R.

    2005-01-01

    Little is known about the breeding biology of the Le Conte's Sparrow (Ammodramus leconteii), probably because of its secretive nature. We provide new information on several aspects of Le Conte's Sparrow breeding biology, including rates of nest parasitism by Brown-headed Cowbirds (Molothrus ater) and potential factors affecting breeding densities and nesting success of the species. Our study was conducted in the tallgrass prairie of northwestern Minnesota and southeastern North Dakota during 1998-2002. Breeding densities varied among years, but this variation was not clearly linked to climatic patterns. Vegetation had some influence on densities of Le Conte's Sparrows; densities were highest in grasslands with moderate amounts of bare ground. Prairie patch size and the percentage of shrubs and trees in the landscape had no recognizable influence on density. Nesting success was highly variable among sites and years and increased slightly with distance from trees. Rates of nest parasitism were low (1 of 50 nests parasitized), and clutch sizes were similar to those of other studies of Le Conte's Sparrows.

  8. 10. VIEW TOWARD PORT BOW IN THE FOC'S'LE OF THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. VIEW TOWARD PORT BOW IN THE FOC'S'LE OF THE EVELINA M. GOULART. OBJECT IN THE FOREGROUND IS A FOLDING MESS TABLE LOCATED BETWEEN THE TIERS OF BUNKS. - Auxiliary Fishing Schooner "Evelina M. Goulart", Essex Shipbuilding Museum, 66 Main Street, Essex, Essex County, MA

  9. Delayed progressive haematoma after Le Fort I osteotomy: A possible severe complication in orthognatic surgery

    PubMed Central

    Bertossi, Dario; Malchiodi, Luciano; Shideh, Ehsani; Albanese, Massimo; Portelli, Marco; Lucchese, Alessandra; Carinci, Francesco; Nocini, Pierfrancesco

    2012-01-01

    Although the Le Fort I osteotomy is a safe surgical technique, many complications have been reported. We present a case of an extended cervico-facial haematoma due to delayed bleeding from the terminal branches of the maxillary artery after orthognatic surgery. A 23-year-old man was referred to our observation for the surgical correction of a class III asymmetric malocclusion. The patient underwent a Le Fort I osteotomy, with impaction of the maxilla, associated with an Epker mandibular bilateral sagittal split osteotomy, with maxillary advancement and rigid internal fixation of the mandible with four miniplates and another four for the upper maxilla as well. The first post-surgery day, the patient developed a gradual dispnea together with neck swelling. By second postoperative day, the patient's general condition improved with a progressive normalization of laboratory tests values. The Computerised Axial Tomography (CAT) scan confirmed a decrease in the parapharyngeal thickening. Total recovery was achieved within two months, the final clinical check showed a healthy appearance with good occlusion. An increased knowledge of the basic biology of the Le Fort I osteotomy, the development of instruments specially designed for the Le Fort I procedure and the use of hypotensive anaesthesia could reduce the morbidity and duration of this procedure. PMID:23814594

  10. Report on a Fulbright Year in France: Toulouse-Le Mirail.

    ERIC Educational Resources Information Center

    Emblidge, David

    1979-01-01

    Describes the experience which seemed to bear out the diagnosis of French history, character, and culture in "Le mal francais" by Peyrefitte. Intra-departmental relationships, the curriculum, course content, student life and attitudes, the physical plant, and the examination system are among the topics discussed. (AMH)

  11. "Le Francais Des Affaires": At the Crossroads of US/EU Trade and Language Policies.

    ERIC Educational Resources Information Center

    Finel-Honigman, Irene

    1997-01-01

    Discusses the need to enhance United States/European Union (EU) commercial and educational cooperation. Differences between US and EU language and trade policies are explored and the importance of plurilingualism in the global economy is examined. The role of the French Language, especially "Le francais des affaires," in facilitating access to the…

  12. Le Chatelier's Principle: The Effect of Temperature on the Solubility of Solids in Liquids.

    ERIC Educational Resources Information Center

    Brice, L. K.

    1983-01-01

    Provides a rigorous but straightforward thermodynamic treatment of the temperature dependence of the solubility of solids in liquids that is suitable for presentation to undergraduates, suggesting how to approach the qualitative aspects of the subject for freshmen. Considers unsolvated/solvated solutes and Le Chatelier's principle. (JN)

  13. Le Schwyzertutsch 5e langue nationale? (Is Swiss German a Fifth National Language?)

    ERIC Educational Resources Information Center

    Redard, Francoise, Ed.; And Others

    1981-01-01

    These papers on the subject of the Swiss German language examine the status and attitudes of the Swiss German speaker, the reaction of other linguistic communities to Swiss German, and the necessity and/or possibility of learning Swiss German. The following articles are included: (1) "Le 'Schwyzertutsch': ecran ou lien? (Is Swiss German a Screen…

  14. Retour vers le futur: l'expérience des patients et le lien avec la qualité, la sécurité et le rendement financier.

    PubMed

    Cochrane, Bonnie S; Hagins, Mitch; King, John A; Picciano, Gino; McCafferty, Maureen M; Nelson, Brian

    2015-11-01

    Au Canada, l'amélioration de l'expérience des patients est devenue une priorité des politiques de santé. Le perfectionnement et la normalisation des outils et systèmes pour surveiller les mesures de l'expérience des patients augmentent, tandis que la tendance vers une plus grande reddition de compte sur des améliorations durables et abordables se confirme. Pour de nombreux professionnels de la santé, ce phénomène fait foi d'un intérêt renouvelé pour les besoins et priorités fondamentaux des patients, après des décennies où les changements structurels et technologiques ont dominé les programmes de santé. Pour les leaders en santé canadiens, l'amélioration de l'expérience des patients comporte actuellement de grands défis et de belles possibilités. À cet égard, l'expérience des organisations partenaires du groupe Studer au Canada est à la fois pertinente et instructive. Ces organisations ont adopté un modèle, du nom de Evidence-Based Leadership (EBL, ou leadership fondé sur des données probantes), qui favorise et soutient l'harmonisation de l'ensemble des activités et des comportements, conformément à des objectifs organisationnels précis, y compris des améliorations mesurables de l'expérience des patients. Le présent article expose des études de cas d'organisations qui ont adopté l'EBL. Ces organisations ont réalisé des progrès rapides en matière d'indicateurs de l'expérience des patients, ainsi que dans des secteurs essentiels comme les résultats cliniques, la sécurité et le rendement financier. Les données émergentes sur les facteurs et processus qui sous-tendent ces améliorations sont également abordées.

  15. Suivi après le traitement du cancer du sein

    PubMed Central

    Sisler, Jeffrey; Chaput, Geneviève; Sussman, Jonathan; Ozokwelu, Emmanuel

    2016-01-01

    Résumé Objectif Offrir aux médecins de famille un résumé des recommandations fondées sur les données probantes pour guider les soins aux survivantes traitées pour le cancer du sein. Qualité des données Une recherche documentaire a été effectuée dans MEDLINE entre 2000 et 2016 à l’aide des mots-clés anglais suivants : breast cancer, survivorship, follow-up care, aftercare, guidelines et survivorship care plans, en se concentrant sur la revue des lignes directrices publiées récemment par les organismes nationaux de cancérologie. Les données étaient de niveaux I à III. Message principal Les soins aux survivantes comportent 4 facettes : surveillance et dépistage, prise en charge des effets à long terme, promotion de la santé et coordination des soins. La surveillance des récidives ne se traduit que par une mammographie annuelle, et le dépistage d’autres cancers doit suivre les lignes directrices basées sur la population. La prise en charge des effets à long terme du cancer et de son traitement aborde des problèmes courants tels la douleur, la fatigue, le lymphœdème, la détresse et les effets indésirables des médicaments, de même que les préoccupations à long terme comme la santé du cœur et des os. La promotion de la santé met en relief les bienfaits de l’activité chez les survivantes du cancer, avec l’accent mis sur l’activité physique. Les soins aux survivantes sont de meilleure qualité lorsque divers services et professionnels de la santé participent aux soins, et le médecin de famille joue un rôle important dans la coordination des soins. Conclusion Les médecins de famille sont de plus en plus souvent les principaux fournisseurs de soins de suivi après le traitement du cancer du sein. Le cancer du sein doit être considéré comme une affection médicale chronique, même chez les femmes en rémission, et les patientes profitent de la même approche que celle utilisée pour les autres affections chroniques en

  16. Le syndrome de cushing chez l'adolescent: à propos de 18 patients

    PubMed Central

    Haraj, Nassim Essabah; El Aziz, Siham; Chadli, Asma

    2015-01-01

    Le syndrome de Cushing est une pathologie rare mais grave chez l'enfant et l'adolescent. Elle diffère de la pathologie adulte par le mode de présentation et la prise en charge. Il s'agit d'une étude rétrospective des dossiers de patients suivis pour syndrome de Cushing au service d'endocrinologie de Casablanca entre 2002 - 2015, incluant les patients âgés au moment du diagnostic de moins de 22 ans, et ayant un suivi d'au moins 1 an. Au total 18 dossiers ont été inclus. L’âge moyen est de 19,55 ans, avec une prédominance féminine. La durée d’évolution moyenne est de 4,05 ans. Le tableau clinique est fait souvent d'une cassure de poids, une obésité ou une séborrhée et acné. La démarche diagnostique est comparable à celle de l'adulte. Sur le plan étiologique on retrouve une prédominance de la maladie de Cushing (15 patients). Sur le plan thérapeutique, 14 patients ont bénéficié d'une chirurgie hypophysaire, avec complément par radiothérapie chez 3 patients devant l’échec de la chirurgie, Une ablation d'une tumeur surrénalienne chez une patiente et une surrénalectomie bilatérale chez trois patients. L’évolution a été marquée par une guérison chez 9 patients et le décès chez 4 (suite à un syndrome de Nelson, infection sévère, choc hémorragique, corticosurrénalome). Les résultats de cette étude soulignent la gravité de cette maladie, ce qui nécessite d'organiser le suivi, en élaborant des programmes spécifiques de suivi médical et de prise en charge psychologique. PMID:26985265

  17. Le cavernome porte chez l'enfant: a propos de 11 cas

    PubMed Central

    Ilham, Tadmori; Mounia, Lakhdar Idrissi; Moustapha, Hida

    2014-01-01

    Le cavernome portal est la conséquence d'une occlusion chronique, du système porte extra-hépatique formé d'un réseau de veines dont le calibre est augmenté et au sein desquelles chemine un sang portal hépatopéte. Chez l'enfant, est une cause majeure d'hypertension portale dite «pré ou infra-hépatique» ou encore «extra-hépatique». Onze cas de cavernome porte parmi 78 cas d'hypertension portale ont été colligés au service sur une période allant du Janvier 2003 au Septembre 2012. L’âge de nos patients variait entre 2 et 15 ans et le sexe ratio est de 1,75. Tous nos patients étaient admis au stade d'hypertension portale avec la splénomégalie SMG (100% des cas); hémorragies digestives (63%); ascite (36%); la circulation veineuse collatérale CVC et l'hépatomégalie HMG (27%). L'exploration endoscopique a objectivé la présence de varices ‘sophagiennes dans tous les cas avec une gastropathie hypertensive dans 27% et des varices ectopiques chez 36%. Les perturbations biologiques étaient dominées par la pancytopénie. Le bilan de thrombophilie était demandé pour tous les malades mais réalisé mais n'est réalisé que chez trois revenus normaux chez deux et a objectivé une baisse de protéine S chez le troisième. L’échographie abdominale était le moyen de diagnostic positif et l’écho-doppler a confirmé l'HTP chez tous nos patients. Aucun de nos malades n'a pu être opéré pour le moment. La ligature a été réalisée chez 54,5%. Dix patients ont nécessité une transfusion sanguine. L’évolution globale de nos patients est favorable. La durée moyenne d’évolution du cavernome porte chez nos patients est de quatre ans. PMID:25870732

  18. Le dermatofibrosarcome de Darier et Ferrand: à propos de 27 cas et revue de la literature

    PubMed Central

    Hammas, Nawal; Badioui, Ikram; Znati, Kaoutar; Benlemlih, Amal; Chbani, Laila; El Fatemi, Hind; Harmouch, Taoufiq; Bouyahyaoui, Youssef; Boutayeb, Faouzi; Mrini, Abdelmajid; Mesbahi, Omar; Mernissi, Fatima Zahra; Amarti, Afaf

    2014-01-01

    Le dermatofibrosarcome de Darier et Ferrand (DFS) est une tumeur mésenchymateuse cutanée de malignité intermédiaire. C'est une tumeur rare mais non exceptionnelle, représentant 0,1% des tumeurs cutanées malignes. Les auteurs présentent une étude rétrospective de 27 cas de DFS diagnostiqués sur une durée de 7 ans (2004 à 2010) et la comparent aux données de la littérature. Cette étude permet d’établir en plus des caractéristiques anatomopathologiques et immunohistochimiques, une étude épidémiologique, clinique et évolutive de ce sarcome. l’âge moyen de nos patients est de 41 ans avec une prédominance masculine. Le tronc est la localisation préférentielle touché dans 52% des cas. La taille tumorale a atteint 30cm et mesure en moyenne 6,1 cm. Le diagnostic était évoqué à l'examen histologique standard et confirmé par l'expression intense et diffuse du CD34. Le traitement était chirurgical, associé à une radiothérapie dans 2 cas. L’évolution était marquée par la transformation en un sarcome pléomorphe de haut grade dans un cas et par la survenue de récidives locales dans 2 cas. Nos résultats sont classiques et comparables aux autres séries de la littérature. L'examen histologique est indispensable pour le diagnostic. L'exérèse chirurgicale large est le traitement de référence. Le pronostic est conditionné par une malignité surtout locale et un fort potentiel de récidive. La transformation sarcomateuse franchement maligne métastasiante est exceptionnelle. PMID:25489374

  19. Gravity in the Century of Light: The Gravitation Theory of Georges-Louis Le Sage

    NASA Astrophysics Data System (ADS)

    Evans, James

    2006-05-01

    Each generation of physicists, or natural philosophers, has sought to place universal gravitation in the context of its own worldview. Often this has entailed an effort to reduce gravitation to something more fundamental. But what is deemed fundamental has, of course, changed with time. Each generation attacked the problem of universal gravitation with the tools of its day and brought to bear the concepts of its own standard model. The most successful eighteenth-century attempt to provide a mechanical explanation of gravity was that of Georges-Louis Le Sage (1724-1803) of Geneva. Le Sage postulated a sea of ultramundane corpuscles, streaming in all directions and characterized by minute mass, great velocity, and complete inelasticity. Mostly these corpuscles just pass through gross bodies such as apples or planets, but a few are absorbed, leading to all the phenomena of attraction. In a voluminous correspondence with nearly all the savants of the day, Le Sage constantly reshaped his arguments for his system in order to appeal to metaphysicians, mechanicians and Newtonians of several varieties. Le Sage's theory is an especially interesting one, for several reasons. First, it serves as the prototype of a dynamical explanation of Newtonian gravity. Second, the theory came quite close to accomplishing its aim. Third, the theory had a long life and attracted comment by the leading physical thinkers of several successive generations, including Laplace, Kelvin, Maxwell and Feynman. Le Sage's theory therefore provides an excellent opportunity for the study of the evolution of attitudes toward physical explanation. The effects of national style in science and generational change take on a new clarity.

  20. Monobloc minus Le Fort II for single-stage treatment of the Apert phenotype.

    PubMed

    Paliga, James Thomas; Goldstein, Jesse A; Storm, Phillip B; Taylor, Jesse Adam

    2013-07-01

    Treatment of the Apert syndrome phenotype aims to correct airway obstruction, exorbitism, elevated intracranial pressure, midface hypoplasia, and malocclusion. Cranial vault expansion prevents elevated intracranial pressure, normalizes head shape, and protects the globes, but variation exists in surgical timing and osteotomy to treat the midface. We present the case of an 11-year-old female patient with Apert syndrome and no prior surgical interventions who presented with severe turribrachycephaly, exorbitism, severe midface retrusion, and apertognathia. A monobloc distraction with simultaneous Le Fort II distraction was planned using computer-aided design and modeling (CAD/CAM) techniques to provide for concurrent distraction of the segments in independent vectors without bony interferences. Monobloc minus Le Fort II distraction was performed without intraoperative complications. Surgical time was 340 minutes with an estimated blood loss of 1100 mL. Distraction began on postoperative day 5 at a rate of 1.5 mm/day for the Le Fort II via an external Halo distractor and 1 mm/day for the monobloc segment via internal distractors anchored bitemporally. The monobloc was distracted a total of 17 mm in a horizontal vector, while the Le Fort II segment was distracted 18 mm horizontally and 5 mm inferiorly. The Halo distractor was removed 3 months following the procedure and the internal distractors 1 month later. Monobloc minus Le Fort II distraction enables correction of the Apert phenotype with a single-stage approach, potentially decreasing the burden of care with improved results. Utilization of CAD/CAM modeling allows for accurate planning of multisegment distraction in independent vectors without concerns for bony interferences.

  1. Monobloc minus Le Fort II for single-stage treatment of the Apert phenotype.

    PubMed

    Paliga, James Thomas; Goldstein, Jesse A; Storm, Phillip B; Taylor, Jesse Adam

    2013-03-01

    Treatment of the Apert syndrome phenotype aims to correct airway obstruction, exorbitism, elevated intracranial pressure, midface hypoplasia, and malocclusion. Cranial vault expansion prevents elevated intracranial pressure, normalizes head shape, and protects the globes, but variation exists in surgical timing and osteotomy to treat the midface. We present the case of an 11-year-old female patient with Apert syndrome and no prior surgical interventions who presented with severe turribrachycephaly, exorbitism, severe midface retrusion, and apertognathia. A monobloc distraction with simultaneous Le Fort II distraction was planned using computer-aided design and modeling (CAD/CAM) techniques to provide for concurrent distraction of the segments in independent vectors without bony interferences.Monobloc minus Le Fort II distraction was performed without intraoperative complications. Surgical time was 340 minutes with an estimated blood loss of 1100 mL. Distraction began on postoperative day 5 at a rate of 1.5 mm/day for the Le Fort II via an external Halo distractor and 1 mm/day for the monobloc segment via internal distractors anchored bitemporally. The monobloc was distracted a total of 17 mm in a horizontal vector, while the Le Fort II segment was distracted 18 mm horizontally and 5 mm inferiorly. The Halo distractor was removed 3 months following the procedure and the internal distractors 1 month later. Monobloc minus Le Fort II distraction enables correction of the Apert phenotype with a single-stage approach, potentially decreasing the burden of care with improved results. Utilization of CAD/CAM modeling allows for accurate planning of multisegment distraction in independent vectors without concerns for bony interferences.

  2. Prévention de la maladie thromboembolique veineuse chez le brûlé

    PubMed Central

    Siah, S.; El Farouki, A.

    2014-01-01

    Summary Les complications thromboemboliques sont considérées comme rares chez le patient brûlé. Leur incidence varie selon les études réalisées. Les patients brûlés présentent de nombreux facteurs de risque favorisant la survenue de ces complications. Le diagnostic clinique de la thrombose veineuse profonde et de l’embolie pulmonaire reste difficile vu leur évolution infraclinique et la non spécificité des signes cliniques. L’échodoppler veineux et l’angioscanner thoracique constituent les éléments clés dans la stratégie diagnostique de la thrombose veineuse profonde et de l’embolie pulmonaire chez les patients brûlés. Le traitement ne diffère pas de celui administré aux autres patients non brûlés et victimes de la thrombose veineuse profonde et de l’embolie pulmonaire. La prophylaxie controversée entre les auteurs, est un sujet d’actualité. Plusieurs praticiens et organismes recommandent son utilisation de routine chez les patients brûlés à risque. Elle reste le seul moyen capable d’empêcher la survenue de la maladie thromboembolique veineuse capable d’engager le pronostic vital chez ces patients. Nous rapportons 6 observations de patients brûlés ayant développé une maladie thromboembolique veineuse. PMID:26170780

  3. Trends in hailstorm frequency in Castile-León (Spain)

    NASA Astrophysics Data System (ADS)

    Merino, A.; García, C.; López, L.; García-Ortega, E.; Sánchez, J. L.; Marcos, J. L.; Guerrero-Higueras, A. M.

    2012-04-01

    The Community of Castile-León is located in the NW of the Iberian Peninsula. One of the most frequent meteorological risks in the Community during the summer is hailstorms. On average, in the Province of León, there are 42 days with storms, almost half of them being hailstorms. However, the spatial variability of the storms is very elevated. The majority of these episodes are registered in mountainous areas during the summer months and they have a convective origin. In the present study, making use of the data from the AEMET's meteorological stations situated in Castile and León, we analyzed trends in the frequency of the appearance of this type of storm from the year 1940 until the present. One of the principal problems we found is that the quality of databases generated from the years without hail precipitation data available are frequent. This is due, in large part, to the difficulty in detecting this type of meteor in meteorological stations, given their large spatial variability and their ephemeral character. On the other hand, with the objective of performing a meteorological analysis of the results found, we have also studied the trends in days with rain and the absolute maximum temperature. The overall analysis of results found allowed us to affirm a large variability in the different regions related to climatic hail series and trends found in those regions. Acknowledgements The authors would like to thank the Regional Government of Castile-León for its financial support through the project LE220A11-2. This study was supported by the following grants: CEN20091028; GRANIMETRO (CGL2010-15930); MICROMETEO (IPT-310000-2010-22 ).

  4. Élaboration et validation d'un modèle numérique reflétant le comportement mécanique du fémur sous chargement statique de compression

    NASA Astrophysics Data System (ADS)

    Jacquet, E.; Garbuio, P.; Pernin, J. N.

    2002-12-01

    Pour tenter d'améliorer les techniques d'ostéosynthèse, afin de réduire les fractures du fémur, apparaît la nécessité de développer un modèle géométrique et numérique capable de caractériser le comportement mécanique du fémur humain. La présente étude propose des résultats expérimentaux issus de tests de compression sur fémurs frais équipés de jauges d'extensomètre. Le modèle géométrique est introduit dans un code de calculs par éléments finis pour représenter le champ des déformations à la surface de l'os. On montre la cohérence du modèle au plan qualitatif et des améliorations pouvant être apportées à ce modèle sont discutées.

  5. Direct Regulation of Extracellular Chitinase Production by the Transcription Factor LeClp in Lysobacter enzymogenes OH11.

    PubMed

    Xu, Huiyong; Chen, Hongfu; Shen, Yuemao; Du, Liangcheng; Chou, Shan-Ho; Liu, Hongxia; Qian, Guoliang; Liu, Fengquan

    2016-09-01

    Lysobacter enzymogenes is a gram-negative bacterial biological control agent that produces abundant extracellular enzymes capable of degrading the cell walls of fungal pathogens. In strain OH11, an isolate from China, the global regulator LeClp controls the production of extracellular chitinase by regulating the transcription of the chitinase-encoding gene chiA. Using a combination of bioinformatic, genetic, and biochemical methods, we show that LeClp regulates chiA transcription by directly binding to the chiA promoter region. Although LeClp appears to be important in this role, it is not the sole regulator of chiA transcription. Furthermore, the sequence analysis of putative LeClp binding sites indicated that the LeClp homolog could be involved in the regulation of extracellular chitinase production in diverse Lysobacter spp. by a mechanism similar to that in L. enzymogenes. Our findings present new insights into the molecular mechanism of LeClp in controlling extracellular chitinase activity, providing a fundamental road to elucidate how LeClp regulates the production of other extracellular lytic enzymes in L. enzymogenes. PMID:27385597

  6. La chirurgie coronaire sous circulation extra-corporelle chez le patient diabétique

    PubMed Central

    Moutakiallah, Younes; Benzaghmout, Khadija; Aithoussa, Mahdi; Atmani, Nourreddine; Amahzoune, Brahim; Hatim, Abdedaim; Drissi, Mohamed; Benyass, Aatif; ElBekkali, Youssef; Boulahya, Abdelatif

    2014-01-01

    Nous rapportons les résultats de la chirurgie coronaire chez une population de coronariens diabétiques opérés sous circulation extra-corporelle dans le service de chirurgie cardiaque de l'hôpital militaire d'instruction Mohammed V de Rabat. C'est une étude rétrospective menée entre Janvier 2008 et Février 2012 (4 ans), portant sur 103 patients diabétiques consécutifs opérés pour pontage coronaire. L’âge moyen des patients était de 61±8,7ans (37-82ans) avec un sexe ratio (H/F) de 3,9. Tous les patients diabétiques de type 2 et sous traitement anti-diabétique ont été inclus dans cette étude. La sténose du tronc commun gauche était présente chez 26,2% des patients et 53,4% étaient tritronculaires. Quatre-vingt patients (78,6%) étaient insulino-nécessitant, l'Euro-score moyen était de 1,63±1% et le nombre moyen de pontage de 2,3±0,7. Les durées moyennes de la circulation extra-corporelle et du clampage aortique étaient respectivement de 134,4 ± 42 min et 76 ± 28 min. La mortalité hospitalière était de 2 décès (1,9%), les durées moyennes de ventilation artificielle, du séjour en réanimation et du séjour postopératoire étaient respectivement de 7h (5-16h), 48h (42-52h) et 15,6 ± 8,6 jours. Les complications postopératoires étaient l'infarctus du myocarde, l'infection de paroi, la médiastinite et le bas débit cardiaque chez respectivement 1,9%, 10,7%, 3,9% et 1,9% des patients. Il ressort de notre étude, que les facteurs prédictifs d'infection post opératoire étaient la durée de ventilation artificielle (p = 0,002), la durée de la circulation extra-corporelle (p < 0,001) en plus du tabac (p = 0,004) et de l'obésité (p = 0,005). Les patients ont été contactés par téléphone ou lors de la consultation régulière de contrôle. Le taux de suivi a atteint 92,1% et la survie à 2 ans était de 98,9% des patients contrôlés avec une mortalité tardive de 1% avec un décès suite à un accident vasculaire c

  7. Curiethérapie dans le traitement palliatif du cancer de l’œsophage

    PubMed Central

    Toulba, Ahmedou; Bakkali, Hanae; Boutayeb, Salwa; Kebdani, Tayeb; Ahid, Samir; Benjaafar, Noureddine

    2015-01-01

    Les patients atteints du cancer de l’œsophage ont souvent une maladie localement avancée, la dysphagie est le symptôme majeur chez la plupart de ces patients, plusieurs modalités thérapeutiques ont été utilisées pour améliorer cette dysphagie. Le but de ce travail est d’étudier l'efficacité et la tolérance de la curiethérapie haut débit de dose (HDR) endo-luminale dans le traitement palliatif des cancers de l’œsophage inopérable. Sur une période de 15 ans, l’étude a inclus les patients atteints de cancer de l’œsophage inopérable et/ou métastatique avec une dysphagie, sans extension à l'hypopharynx ou a la trachée et qui ont bénéficié d'une curiethérapie HDR avec ou sans radiothérapie externe à visée palliative. Au total 46 patients ont été inclus dans l’étude, 58,7% étaient des hommes, 42,2% avaient une dysphagie grade 2 et 37,8% étaient aphagiques, 78,6% des patients étaient performance satus PS 2, l'amaigrissement à été trouvé chez 81,4%, la localisation de la tumeur était surtout au niveau du tiers moyen et inférieur dans 97,8%, la hauteur médiane de la tumeur était de 7 cm (5,5-9), le carcinome épidermoïde était le type histologique le plus fréquent chez 31 patients (70,5%). Après un médiane de suivi de 5 mois, l'amélioration de la dysphagie a été retrouvée chez 76% des malades (p1]. L′incidence la plus élevée est observée dans certains pays notamment en Asie et en Afrique, et l′incidence dans les pays développés occidentaux est en augmentation [2]. Selon le registre du cancer de Rabat 2006-2008, le cancer de l’œsophage est rare et constitue 1,5% de tous les cancers chez l'homme [3]. Le taux de survie globale à 5 ans est de 8%, avec 80% des décès liés à l’évolution locale de la maladie [4]. Pour la minorité des patients avec une maladie localisée, le traitement par radiochimiothérapie concomitante avec ou sans chirurgie permet une amélioration de la survie [5]. Plus de 50

  8. Fine mapping of qSB-11(LE), the QTL that confers partial resistance to rice sheath blight.

    PubMed

    Zuo, Shimin; Yin, Yuejun; Pan, Cunhong; Chen, Zongxiang; Zhang, Yafang; Gu, Shiliang; Zhu, Lihuang; Pan, Xuebiao

    2013-05-01

    Sheath blight (SB), caused by Rhizoctonia solani kühn, is one of the most serious global rice diseases. No major resistance genes to SB have been identified so far. All discovered loci are quantitative resistance to rice SB. The qSB-11(LE) resistance quantitative trait locus (QTL) has been previously reported on chromosome 11 of Lemont (LE). In this study, we report the precise location of qSB-11 (LE) . We developed a near isogenic line, NIL-qSB11(TQ), by marker-assisted selection that contains susceptible allele(s) from Teqing (TQ) at the qSB-11 locus in the LE genetic background. NIL-qSB11(TQ) shows higher susceptibility to SB than LE in both field and greenhouse tests, suggesting that this region of LE contains a QTL contributing to SB resistance. In order to eliminate the genetic background effects and increase the accuracy of phenotypic evaluation, a total of 112 chromosome segment substitution lines (CSSLs) with the substituted segment specific to the qSB-11 (LE) region were produced as the fine mapping population. The genetic backgrounds and morphological characteristics of these CSSLs are similar to those of the recurrent parent LE. The donor TQ chromosomal segments in these CSSL lines contiguously overlap to bridge the qSB-11 (LE) region. Through artificial inoculation, all CSSLs were evaluated for resistance to SB in the field in 2005. For the recombinant lines, their phenotypes were evaluated in the field for another 3 years and during the final year were also evaluated in a controlled greenhouse environment, showing a consistent phenotype in SB resistance across years and conditions. After comparing the genotypic profile of each CSSL with its phenotype, we are able to localize qSB-11 (LE) to the region defined by two cleaved-amplified polymorphic sequence markers, Z22-27C and Z23-33C covering 78.871 kb, based on the rice reference genome. Eleven putative genes were annotated within this region and three of them were considered the most likely

  9. L'atteinte osseuse dans le sarcome de Kaposi classique et agressif: à propos d'un cas

    PubMed Central

    Sbiyaa, Mouhcine; El Alaoui, Adil; El Bardai, Mohammed; Mezzani, Amine; Lahrach, Kamal; Marzouki, Amine; Boutayeb, Fawzi

    2016-01-01

    Le sarcome de Kaposi classique est une tumeur rare multifocale d'origine des cellules endothéliales vasculaires à caractère évolutif progressif et peu maligne. L'atteinte viscérale dans le sarcome de kaposi est parfois observée chez les patients VIH positif par contre la dissémination tumorale dans les ganglions lymphatiques viscérales dans le SK classique reste très rare. On rapporte un cas rare de sarcome de kaposi classique agressif de la main avec une évolution rapide et destructive. PMID:27347285

  10. Mise à jour sur le nouveau vaccin 9-valent pour la prévention du virus du papillome humain

    PubMed Central

    Yang, David Yi; Bracken, Keyna

    2016-01-01

    Résumé Objectif Informer les médecins de famille quant à l’efficacité, à l’innocuité, aux effets sur la santé publique et à la rentabilité du vaccin 9-valent contre le virus du papillome humain (VPH). Qualité des données Des articles pertinents publiés dans PubMed jusqu’en mai 2015 ont été examinés et analysés. La plupart des données citées sont de niveau I (essais randomisés et contrôlés et méta-analyses) ou de niveau II (études transversales, cas-témoins et épidémiologiques). Des rapports et recommandations du gouvernement sont aussi cités en référence. Message principal Le vaccin 9-valent contre le VPH, qui offre une protection contre les types 6, 11, 16, 18, 31, 33, 45, 52 et 58 du VPH, est sûr et efficace et réduira encore plus l’incidence des infections à VPH, de même que les cas de cancer lié au VPH. Il peut également protéger indirectement les personnes non immunisées par l’entremise du phénomène d’immunité collective. Un programme d’immunisation efficace peut prévenir la plupart des cancers du col de l’utérus. Les analyses montrent que la rentabilité du vaccin 9-valent chez les femmes est comparable à celle du vaccin quadrivalent original contre le VPH (qui protège contre les types 6, 11, 16 et 18 du VPH) en usage à l’heure actuelle. Toutefois, il faut investiguer plus en profondeur l’utilité d’immuniser les garçons avec le vaccin 9-valent contre le VPH. Conclusion en plus d’être sûr, le vaccin 9-valent protège mieux contre le VPH que le vaccin quadrivalent. Une analyse coûtefficacité en favorise l’emploi, du moins chez les adolescentes. Ainsi, les médecins devraient recommander le vaccin 9-valent à leurs patients plutôt que le vaccin quadrivalent contre le VPH.

  11. Euptychia boulleti (Le Cerf) n. comb. (Lepidoptera: Nymphalidae: Satyrinae), a rare and endangered butterfly from Southeastern Brazil.

    PubMed

    Freitas, A V L; Wahlberg, N; Matos-Maravi, P F; Marin, M A; Mielke, O H H

    2012-12-01

    This paper discusses the systematic position of the rare and endangered satyrine butterfly Caenoptychia boulleti Le Cerf, the only included species in Caenoptychia (type species), based on adult morphology and molecular data. The results showed that Caenoptychia Le Cerf belongs to the Euptychia Hübner clade, and the genus is synonymized with Euptychia, new synonymy. Euptychia boulleti (Le Cerf) is a new combination. The male genitalia of E. boulleti showed at least one important synapomorphy with the other species of Euptychia, which is the presence of a posterior projection of the tegumen above the uncus. Molecular data reinforces the position of Caenoptychia within the genus Euptychia.

  12. Kyste hydatique du foie rompu dans la paroi abdominale et dans le muscle psoas : à propos d'une rare observation

    PubMed Central

    En-Nafaa, Issam; Moujahid, Mountassir; Alahyane, Abdelouahabe; Amil, Touria; Hanine, Ahmed; Ziadi, Tarik

    2011-01-01

    Le kyste hydatique du foie est une parasitose qui sévit à l′état endémique au maroc. La rupture dans la paroi abdominale et dans le psoas est une complication exceptionnelle. Nous rapportons un cas de kyste hydatique du foie rompu dans la paroi et dans le muscle psoas. Le diagnostic a été établi sur les données de l′échographie et surtout de la tomodensitométrie. Le patient a été opéré avec des suites simples. PMID:22187585

  13. La prise en charge d’une clientèle

    PubMed Central

    Roy, Andréanne; Breton, Mylaine; Loslier, Julie

    2016-01-01

    Résumé Objectif Analyser les facteurs qui incitent les médecins de famille nouvellement autorisés à faire de la prise en charge d’une clientèle en première ligne. Type d’étude Devis mixte séquentiel : questionnaire en ligne auto-administré auprès de médecins de famille, suivi d’entrevues individuelles. Contexte La Montérégie, qui est la deuxième région la plus populeuse du Québec, et qui présente des zones rurales et urbaines. Participants Tous les médecins de famille détenant un poste en Montérégie et ayant moins de 10 années d’expérience ont été sollicités, soit 366 médecins. Parmi eux, 118 ont complété le questionnaire en ligne (taux de réponse de 32,2 %). Parmi les répondants, 10 médecins ayant des profils de prise en charge variés ont été sélectionnés pour les entrevues individuelles. Principaux paramètres à l’étude Le pourcentage de temps de travail consacré à la prise en charge, analysé en parallèle avec différents facteurs facilitants et barrières à la prise en charge aux niveaux contextuel, organisationnel, du médecin de famille et de la clientèle. Résultats Les principaux facteurs facilitant la prise en charge sont la relation médecin-patient, l’intérêt pour les activités cliniques liées à la prise en charge, les modèles de rôles positifs, la collaboration avec une infirmière et l’accès adéquat aux ressources, notamment en santé mentale. Les principales barrières sont l’ampleur des tâches administratives, l’intérêt pour une pratique polyvalente, l’expérience négative de la prise en charge lors de la formation, un sentiment n’inaptitude à l’égard de la prise en charge, la lourdeur de la clientèle et le manque de soutien en début de pratique. Conclusion Certaines pistes de solution pour inciter les nouveaux médecins de famille à prendre en charge une clientèle sont proposées. Des points d’amélioration au niveau de la formation médicale, du soutien

  14. Are bioresorbable polylactate devices comparable to titanium devices for stabilizing Le Fort I advancement?

    PubMed

    Blakey, G H; Rossouw, E; Turvey, T A; Phillips, C; Proffit, W R; White, R P

    2014-04-01

    The purpose of this study was to evaluate whether skeletal and dental outcomes following Le Fort I surgery differed when stabilization was performed with polylactate bioresorbable devices or titanium devices. Fifty-seven patients with preoperative records and at least 1 year postoperative records were identified and grouped according to the stabilization method. All cephalometric X-rays were traced and digitized by a single operator. Analysis of covariance was used to compare the postsurgical change between the two stabilization methods. Twenty-seven patients received bioresorbable devices (group R), while 30 received titanium devices (group M). There were no statistically significant differences between the two groups with respect to gender, race/ethnicity, age, or dental and skeletal movements during surgery. Subtle postsurgical differences were noted, but were not statistically significant. Stabilization of Le Fort I advancement with polylactate bioresorbable and titanium devices produced similar clinical outcomes at 1 year following surgery.

  15. Le Fort I advancement osteotomies of 1 cm or more. How safe or stable?

    PubMed

    Bhatia, Satyajeet; Bocca, Alan; Jones, Judy; Sugar, Adrian W

    2016-04-01

    We studied the results and stability of Le Fort I maxillary osteotomies with advancement of at least 1cm. We analysed prospective data from 32 consecutive patients who were operated on by a single surgeon between 1985 and 2007, and who had mean advancement of the maxilla of 14 mm (range 10-22 mm). Mean relapse for all cases antero-posteriorly was 1mm, 10% (range 0-4mm). Relapse was marginally greater in the 24 patients with a repaired cleft palate (11%) compared with those without a cleft (8%). The results were essentially stable at least one year after surgery and without significant complications. This study indicates that Le Fort I osteotomies of 1cm or more carried out in the way described are safe and stable.

  16. High Le Fort I osteotomy for correction of mid-face deformity in Crouzon syndrome.

    PubMed

    Nakajima, Yasumichi; Nakano, Hiroyuki; Sumida, Tomoki; Yamada, Tomohiro; Inoue, Kazuya; Sugiyama, Goro; Mishima, Katsuaki; Mori, Yoshihide

    2016-09-01

    An 18-year-old woman with mild Crouzon syndrome was referred with malocclusion and mandibular protrusion. Examination revealed Class III canine and molar relationships, hypoplastic maxilla, 1-mm overbite, and -2-mm overjet. Analysis showed 69° sella-nasion-A, 73.6° sella-nasion-B, and -4.6° A point-nasion-B point angles. Polysomnography revealed respiratory disturbance and 6.3% oxygen desaturation indices of 5.4/h and 9.0/h. We performed double-jaw surgery using high Le Fort I osteotomy and bilateral sagittal split ramus osteotomy for midfacial deformity correction. Twelve months post-surgery, her measures were 70.8°, 72°, -1.2°, 3.0/h, and 6.1/h, respectively. Esthetics were satisfactory. High Le Fort I osteotomy is effective for midfacial deformity correction in patients with Crouzon syndrome.

  17. Mesure de la biréfringence magnétique du vide : le projet BMV

    NASA Astrophysics Data System (ADS)

    Askenazy, S.; Billette, J.; Dupré, P.; Ganau, P.; Mackowski, J.; Marquez, J.; Pinard, L.; Portugall, O.; Ricard, D.; Rikken, G. L. J. A.; Rizzo, C.; Trénec, G.; Vigué, J.

    2002-06-01

    Notre projet porte sur la mesure de la biréfringence induite par un champ magnétique dans le vide. La grande nouveauté par rapport aux expériences antérieures tient dans l'usage d'un aimant pulsé adapté: cet aimant produira environ B = 25 tesla sur une longueur L = 1,5 m (l'effet est proportionnel au produit B^2L). La construction d'un prototype de l'aimant pulsé est déjà commencée. En parallèle, nous avons lancé la réalisation d'un ellipsomètre basé sur une cavité de très haute finesse.

  18. A Rotating Stall Type Phenomenon Caused by Cavitation in LE-7A LH2 Turbopump

    NASA Astrophysics Data System (ADS)

    Shimura, Takashi; Yoshida, Makoto; Kamijo, Kenjiro; Uchiumi, Masaharu; Yasutomi, Yoshinobu

    The cause of 350 Hz large-amplitude rotor vibration of the H-2A rocket's LE-7A fuel turbopump was investigated by wideband oscillating-pressure measurement. Measurement was successfully conducted by quartz-type pressure sensors in full-load liquid-hydrogen tests. The phase difference of pressure oscillations between two pressure measurement ports under conditions of pump cavitating operation revealed a phenomenon similar to rotating stall in turbomachinery which had not been previously observed. The rotating speed of a cell was 350 Hz, about a half the rotor speed. This phenomenon is different from rotating cavitation in which the cavitation pattern rotates around the periphery of an impeller faster than shaft rotating speed. Based on these findings, it was concluded that this phenomenon cased the large-amplitude 350 Hz vibration of the LE-7A fuel turbopump. Results of FFT analysis of measured oscillating pressure are presented.

  19. The effects of geometry in the dynamic response of the cavitating LE-7 LOX pump

    NASA Astrophysics Data System (ADS)

    Shimura, Takashi

    1993-06-01

    The dynamic response of the cavitating LE-7 LOX pump, which is essential for POGO analysis of the H-II rocket, was determined by generating sinusoidal flow perturbation with a slit-type perturbation valve installed in the main pump discharge line. In a study of suppressing the LE-7 LOX turbopump rotor vibration due to cavitation, it was found that a kind of rotor vibration, thought to be caused by rotating cavitation, disappeared when a certain geometry of inducer housing was used. Therefore, the effects of inducer-housing geometry on cavitation compliance and on the mass flow gain factor were investigated. Comparison of the test results showed that cavitation compliance for the geometry in which the rotor vibration due to rotating cavitation disappeared was much larger than that for the geometry in which the rotor vibration existed.

  20. High Le Fort I osteotomy for correction of mid-face deformity in Crouzon syndrome.

    PubMed

    Nakajima, Yasumichi; Nakano, Hiroyuki; Sumida, Tomoki; Yamada, Tomohiro; Inoue, Kazuya; Sugiyama, Goro; Mishima, Katsuaki; Mori, Yoshihide

    2016-09-01

    An 18-year-old woman with mild Crouzon syndrome was referred with malocclusion and mandibular protrusion. Examination revealed Class III canine and molar relationships, hypoplastic maxilla, 1-mm overbite, and -2-mm overjet. Analysis showed 69° sella-nasion-A, 73.6° sella-nasion-B, and -4.6° A point-nasion-B point angles. Polysomnography revealed respiratory disturbance and 6.3% oxygen desaturation indices of 5.4/h and 9.0/h. We performed double-jaw surgery using high Le Fort I osteotomy and bilateral sagittal split ramus osteotomy for midfacial deformity correction. Twelve months post-surgery, her measures were 70.8°, 72°, -1.2°, 3.0/h, and 6.1/h, respectively. Esthetics were satisfactory. High Le Fort I osteotomy is effective for midfacial deformity correction in patients with Crouzon syndrome. PMID:27092811

  1. The Potassium-Argon Laser Experiment (KArLE): In Situ Geochronology for Planetary Robotic Missions

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara

    2016-01-01

    The Potassium (K) - Argon (Ar) Laser Experiment (KArLE) will make in situ noble-gas geochronology measurements aboard planetary robotic landers and roverss. Laser-Induced Breakdown Spectroscopy (LIBS) is used to measure the K abun-dance in a sample and to release its noble gases; the evolved Ar is measured by mass spectrometry (MS); and rela-tive K content is related to absolute Ar abundance by sample mass, determined by optical measurement of the ablated volume. KArLE measures a whole-rock K-Ar age to 10% or better for rocks 2 Ga or older, sufficient to resolve the absolute age of many planetary samples. The LIBS-MS approach is attractive because the analytical components have been flight proven, do not require further technical development, and provide complementary measurements as well as in situ geochronology.

  2. Overexpression of the Tomato Pollen Receptor Kinase LePRK1 Rewires Pollen Tube Growth to a Blebbing Mode[W][OPEN

    PubMed Central

    Gui, Cai-Ping; Dong, Xin; Liu, Hai-Kuan; Huang, Wei-Jie; Zhang, Dong; Wang, Shu-Jie; Barberini, María Laura; Gao, Xiao-Yan; Muschietti, Jorge; McCormick, Sheila

    2014-01-01

    The tubular growth of a pollen tube cell is crucial for the sexual reproduction of flowering plants. LePRK1 is a pollen-specific and plasma membrane–localized receptor-like kinase from tomato (Solanum lycopersicum). LePRK1 interacts with another receptor, LePRK2, and with KINASE PARTNER PROTEIN (KPP), a Rop guanine nucleotide exchange factor. Here, we show that pollen tubes overexpressing LePRK1 or a truncated LePRK1 lacking its extracellular domain (LePRK1ΔECD) have enlarged tips but also extend their leading edges by producing “blebs.” Coexpression of LePRK1 and tomato PLIM2a, an actin bundling protein that interacts with KPP in a Ca2+-responsive manner, suppressed these LePRK1 overexpression phenotypes, whereas pollen tubes coexpressing KPP, LePRK1, and PLIM2a resumed the blebbing growth mode. We conclude that overexpression of LePRK1 or LePRK1ΔECD rewires pollen tube growth to a blebbing mode, through KPP- and PLIM2a-mediated bundling of actin filaments from tip plasma membranes. Arabidopsis thaliana pollen tubes expressing LePRK1ΔECD also grew by blebbing. Our results exposed a hidden capability of the pollen tube cell: upon overexpression of a single membrane-localized molecule, LePRK1 or LePRK1ΔECD, it can switch to an alternative mechanism for extension of the leading edge that is analogous to the blebbing growth mode reported for Dictyostelium and for Drosophila melanogaster stem cells. PMID:25194029

  3. Orientation of the JPL Ephemerides, DE 200/LE 200, to the dynamical equinox of J 2000

    NASA Technical Reports Server (NTRS)

    Standish, E. M., Jr.

    1982-01-01

    The lunar and planetary ephemerides, DE 200/LE 200 have been recently produced at JPL. They will form the basis of the ephemerides in the 'Astronomical Almanac' starting in the year 1984. The origin has been referenced to the J 2000 dynamical equinox of the ephemerides themselves. The procedure for this orientation is described here in detail. Analyses of the ephemerides also provide comparisons with the equinox of the FK 4 and with presently adopted values for the earth's obliquity.

  4. Validity of three-dimensional computed tomography measurements for Le Fort I osteotomy.

    PubMed

    Gaia, B F; Pinheiro, L R; Umetsubo, O S; Costa, F F; Cavalcanti, M G P

    2014-02-01

    The purpose of this study was to test the precision and accuracy of three-dimensional (3D) linear measurements for Le Fort I osteotomy, obtained from multi-slice computed tomography (MSCT) and cone beam computed tomography (CBCT) scans. The study population consisted of 11 dried skulls submitted to 64-row MSCT and CBCT scans. Three-dimensional reconstructed images (3D-CT) were generated, and linear measurements (n=11) based on anatomical structures and landmarks of interest for Le Fort I osteotomy were performed independently by two oral and maxillofacial radiologists, twice each, using Vitrea software; this allows true 3D measurement on 3D-CT images. The results demonstrated no statistically significant differences between the inter-examiner and intra-examiner analyses, and physical and true 3D linear measurements using MSCT and CBCT images. Regarding examiner accuracy, no statistically significant differences were found for the comparisons among the physical and the MSCT and the CBCT linear measurements by either examiner. For examiners 1 and 2, the analysis intra-examiner correlation coefficient ranged from 0.87 to 0.96 and 0.82 to 0.98, respectively, using MSCT, and from 0.84 to 0.98 and 0.80 to 0.98, respectively, using CBCT, indicating almost perfect agreement for all analyses performed. 3D linear measurements obtained from MSCT and CBCT images were considered precise and accurate for Le Fort I osteotomy and thus accurate and helpful for Le Fort I osteotomy planning.

  5. Magnétométrie à hélium par pompage laser: le bilan

    NASA Astrophysics Data System (ADS)

    Gilles, H.; Hamel, J.; Monfort, Y.

    2002-06-01

    Depuis 1986, l'équipe Physique Atomique et Capteurs du CIRIL-ISMRA de Caen étudie les magnétomètres à hélium par pompage laser. On présente ici le bilan de ces travaux de recherche et les performances des deux prototypes (hélium4 et hélium3) réalisés au Laboratoire.

  6. Poles of integrále tritronquée and anharmonic oscillators. A WKB approach

    NASA Astrophysics Data System (ADS)

    Masoero, Davide

    2010-03-01

    Poles of solutions to the Painlevé-I equations are intimately related to the theory of the cubic anharmonic oscillator. In particular, poles of integrále tritronquée are in bijection with cubic oscillators that admit the simultaneous solutions of two quantization conditions. We analyze this pair of quantization conditions by means of a suitable version of the complex WKB method. Ai miei zii Ivan e Silvia.

  7. Development of the Potassium-Argon Laser Experiment (KArLE) Instrument for In Situ Geochronology

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.; Li, Z.-H.; Miller, J. S.; Brinckerhoff, W. B.; Clegg, S. M.; Mahaffy, P. R.; Swindle, T. D.; Wiens, R. C.

    2012-01-01

    Absolute dating of planetary samples is an essential tool to establish the chronology of geological events, including crystallization history, magmatic evolution, and alteration. Traditionally, geochronology has only been accomplishable on samples from dedicated sample return missions or meteorites. The capability for in situ geochronology is highly desired, because it will allow one-way planetary missions to perform dating of large numbers of samples. The success of an in situ geochronology package will not only yield data on absolute ages, but can also complement sample return missions by identifying the most interesting rocks to cache and/or return to Earth. In situ dating instruments have been proposed, but none have yet reached TRL 6 because the required high-resolution isotopic measurements are very challenging. Our team is now addressing this challenge by developing the Potassium (K) - Argon Laser Experiment (KArLE) under the NASA Planetary Instrument Definition and Development Program (PIDDP), building on previous work to develop a K-Ar in situ instrument [1]. KArLE uses a combination of several flight-proven components that enable accurate K-Ar isochron dating of planetary rocks. KArLE will ablate a rock sample, determine the K in the plasma state using laser-induced breakdown spectroscopy (LIBS), measure the liberated Ar using quadrupole mass spectrometry (QMS), and relate the two by the volume of the ablated pit using an optical method such as a vertical scanning interferometer (VSI). Our preliminary work indicates that the KArLE instrument will be capable of determining the age of several kinds of planetary samples to +/-100 Myr, sufficient to address a wide range of geochronology problems in planetary science.

  8. Neurological and psychological constructs in Sheridan Le Fanu's In a Glass Darkly.

    PubMed

    Ginn, Sheryl R

    2013-01-01

    Excepting "Green Tea" and "Carmilla," Sheridan Le Fanu's fiction is generally neglected by modern-day readers, yet his work reveals much information about the conduct of life in nineteenth century Ireland and England. Le Fanu's works should be appreciated for the insights he provides into the psychology of his characters; his fiction was written prior to what historians of psychology date as the formal establishment of the discipline in 1879, which occurred after his death. His fiction also illustrates the emerging medical specialty of neurology, although Le Fanu's later writings are more illustrative of his interest in the mystical works of Emanuel Swedenborg. His characters frequently suffer from "brain fevers" and other maladies that were the subject of intense debate in England, continental Europe, and America. His male characters in particular suffer from guilty consciences, and suicide is a frequent fate. Each of these aspects of Le Fanu's fiction can be found in the 1872 collection In a Glass Darkly, which purports to contain five case histories of the German metaphysical physician Doctor Martin Hesselius. In this chapter, each of the stories in the collection will be described and analyzed for Hesselius' use of psychological, neurological, or mystical explanations for the events occurring within the story. Hesselius' descriptions of psychological constructs are rather advanced for a physician discussing mental disorders in the nineteenth century. His theories within this collection of stories with respect to neurology and neuroscience, on the other hand, are much more representative of the eighteenth century, something that would be natural given that the stories contained in the collection were purported to have occurred in the latter decades of the eighteenth or early decades of the nineteenth century. PMID:24290262

  9. An Update on Midface Advancement Using Le Fort II and III Distraction Osteogenesis.

    PubMed

    Tahiri, Youssef; Taylor, Jesse

    2014-11-01

    Le Fort II and III distraction osteogenesis (DO) is a powerful tool in the craniofacial armamentarium that is most often employed to treat patients with craniofacial syndromes such as Crouzon, Apert, or Pfeiffer syndrome who present with midfacial retrusion, shallow orbits, exorbitism, malocclusion, obstructive sleep apnea and facial imbalance. In this article, the authors will provide the reader with an update on techniques for the treatment of various forms of midfacial retrusion. PMID:25383053

  10. Neurological and psychological constructs in Sheridan Le Fanu's In a Glass Darkly.

    PubMed

    Ginn, Sheryl R

    2013-01-01

    Excepting "Green Tea" and "Carmilla," Sheridan Le Fanu's fiction is generally neglected by modern-day readers, yet his work reveals much information about the conduct of life in nineteenth century Ireland and England. Le Fanu's works should be appreciated for the insights he provides into the psychology of his characters; his fiction was written prior to what historians of psychology date as the formal establishment of the discipline in 1879, which occurred after his death. His fiction also illustrates the emerging medical specialty of neurology, although Le Fanu's later writings are more illustrative of his interest in the mystical works of Emanuel Swedenborg. His characters frequently suffer from "brain fevers" and other maladies that were the subject of intense debate in England, continental Europe, and America. His male characters in particular suffer from guilty consciences, and suicide is a frequent fate. Each of these aspects of Le Fanu's fiction can be found in the 1872 collection In a Glass Darkly, which purports to contain five case histories of the German metaphysical physician Doctor Martin Hesselius. In this chapter, each of the stories in the collection will be described and analyzed for Hesselius' use of psychological, neurological, or mystical explanations for the events occurring within the story. Hesselius' descriptions of psychological constructs are rather advanced for a physician discussing mental disorders in the nineteenth century. His theories within this collection of stories with respect to neurology and neuroscience, on the other hand, are much more representative of the eighteenth century, something that would be natural given that the stories contained in the collection were purported to have occurred in the latter decades of the eighteenth or early decades of the nineteenth century.

  11. SCaLeM: A Framework for Characterizing and Analyzing Execution Models

    SciTech Connect

    Chavarría-Miranda, Daniel; Manzano Franco, Joseph B.; Krishnamoorthy, Sriram; Vishnu, Abhinav; Barker, Kevin J.; Hoisie, Adolfy

    2014-10-13

    As scalable parallel systems evolve towards more complex nodes with many-core architectures and larger trans-petascale & upcoming exascale deployments, there is a need to understand, characterize and quantify the underlying execution models being used on such systems. Execution models are a conceptual layer between applications & algorithms and the underlying parallel hardware and systems software on which those applications run. This paper presents the SCaLeM (Synchronization, Concurrency, Locality, Memory) framework for characterizing and execution models. SCaLeM consists of three basic elements: attributes, compositions and mapping of these compositions to abstract parallel systems. The fundamental Synchronization, Concurrency, Locality and Memory attributes are used to characterize each execution model, while the combinations of those attributes in the form of compositions are used to describe the primitive operations of the execution model. The mapping of the execution model’s primitive operations described by compositions, to an underlying abstract parallel system can be evaluated quantitatively to determine its effectiveness. Finally, SCaLeM also enables the representation and analysis of applications in terms of execution models, for the purpose of evaluating the effectiveness of such mapping.

  12. Une formation à la recherche en médecine transfusionnelle dans le monde francophone

    PubMed Central

    Shiboski, C.; Fontanet, A.; Murphy, E.L.

    2010-01-01

    Un enseignement accéléré et francophone de formation à la recherche en médecine transfusionnelle a été récemment instauré à l’Institut Pasteur de Paris, sous la codirection de membres hospitalo-universitaires de l’université de Californie San Francisco (UCSF), du Blood Systems Research Institute (BSRI) et de l’Institut national de la transfusion sanguine (INTS). Le but est de former des professionnels de la transfusion des pays en voie de développement à mener une activité de recherche dont les résultats peuvent contribuer à un renforcement de la qualité des soins transfusionnels et de la sécurité transfusionnelle dans leur pays. Le cours enseigne les méthodes de recherche clinique et épidémiologique, et leurs applications transfusionnelles potentielles. Chaque étudiant élabore au cours du stage un protocole personnel de recherche, qu’il lui sera loisible de mettre ensuite en pratique dans le centre de transfusion ou l’hôpital où il exerce. PMID:19640755

  13. Soft tissue changes and skeletal stability after modified quadrangular Le Fort I osteotomy.

    PubMed

    Lee, H-J; Park, H-S; Kyung, H-M; Kwon, T-G

    2015-03-01

    The purpose of this study was to evaluate the soft tissue changes and skeletal stability of a modification of the Le Fort I osteotomy design - the modified quadrangular Le Fort I osteotomy (MQLI). Patients who had maxillary advancement and mandibular setback surgery for skeletal class III malocclusion with a midface deficiency were included. MQLI patients (n=20) were compared to conventional Le Fort I osteotomy patients (LFI) (n=20) using cephalometric radiographs taken preoperatively (T0), immediately postoperative (T1), and at >6 months postoperative (T2). Soft tissue radiographic changes of the cheek line and perinasal areas, and skeletal movements were analyzed. The basic skeletal characteristics and amount of maxillary and mandibular surgical change were similar in the two groups (group difference, P>0.05). There was no significant difference between the two groups in terms of maxillary and mandibular skeletal stability. The cheek profile angle increased significantly after MQLI by 3.5° (P<0.05), whereas LFI showed a 2.1° increase (P>0.05). Overall, the soft tissue cheek outline moved significantly more anteriorly in MQLI, but the difference to LFI osteotomy did not reach statistical significance. MQLI could be an efficient and stable surgical method to improve maxillary and infraorbital hypoplasia without malar advancement, especially in Asian patients.

  14. Three-dimensional position changes of the midface following Le Fort III advancement in syndromic craniosynostosis.

    PubMed

    Bouw, Frederik P; Nout, Erik; van Bezooijen, Jine S; Koudstaal, Maarten J; Veenland, Jifke F; Wolvius, Eppo B

    2015-07-01

    Little is known about the positional change of the Le Fort III segment following advancement. To study this, pre- and postoperative computed tomography scans of 18 craniosynosthosis patients were analyzed. The Le Fort III segment movement was measured by creating a reference coordinate system and by superpositioning the postoperative over the preoperative scan. On both the pre- and postoperative scans, four anatomical landmarks were marked: the most anterior point of the left and right foramen infraorbitale, the nasion, and the anterior nasal spine. A significant anterior movement of the four reference points was observed. No significant transversal differences were found. A significant difference between the anterior movement of the nasion and anterior nasal spine was found. In vertical dimension, there was a significant cranial movement of nasion in the study group. In addition, from all patients standardized lateral X-rays were viewed to determine the location and direction of force application that were linked to the outcomes of the three-dimensional movement of the nasion and anterior nasal spine (ANS) and the surgical technique. Conclusively, a significant advancement of the midface can be achieved with Le Fort III distraction osteogenesis in this specific patient group. Counterclockwise movement seemed to be the most dominant movement despite different modes of anchorage.

  15. The NASA LeRC regenerative fuel cell system testbed program for goverment and commercial applications

    SciTech Connect

    Maloney, T.M.; Voecks, G.E.

    1995-01-25

    The Electrochemical Technology Branch of the NASA Lewis Research Center (LeRC) has initiated a program to develop a renewable energy system testbed to evaluate, characterize, and demonstrate fully integrated regenerative fuel cell (RFC) system for space, military, and commercial applications. A multi-agency management team, led by NASA LeRC, is implementing the program through a unique international coalition which encompasses both government and industry participants. This open-ended teaming strategy optimizes the development for space, military, and commercial RFC system technologies. Program activities to date include system design and analysis, and reactant storage sub-system design, with a major emphasis centered upon testbed fabrication and installation and testing of two key RFC system components, namely, the fuel cells and electrolyzers. Construction of the LeRC 25 kW RFC system testbed at the NASA-Jet Propulsion Labortory (JPL) facility at Edwards Air Force Base (EAFB) is nearly complete and some sub-system components have already been installed. Furthermore, planning for the first commercial RFC system demonstration is underway. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}

  16. The NASA LeRC regenerative fuel cell system testbed program for goverment and commercial applications

    NASA Astrophysics Data System (ADS)

    Maloney, Thomas M.; Prokopius, Paul R.; Voecks, Gerald E.

    1995-01-01

    The Electrochemical Technology Branch of the NASA Lewis Research Center (LeRC) has initiated a program to develop a renewable energy system testbed to evaluate, characterize, and demonstrate fully integrated regenerative fuel cell (RFC) system for space, military, and commercial applications. A multi-agency management team, led by NASA LeRC, is implementing the program through a unique international coalition which encompasses both government and industry participants. This open-ended teaming strategy optimizes the development for space, military, and commercial RFC system technologies. Program activities to date include system design and analysis, and reactant storage sub-system design, with a major emphasis centered upon testbed fabrication and installation and testing of two key RFC system components, namely, the fuel cells and electrolyzers. Construction of the LeRC 25 kW RFC system testbed at the NASA-Jet Propulsion Labortory (JPL) facility at Edwards Air Force Base (EAFB) is nearly complete and some sub-system components have already been installed. Furthermore, planning for the first commercial RFC system demonstration is underway.

  17. Students' and teachers' misapplication of le chatelier's principle: Implications for the teaching of chemical equilibrium

    NASA Astrophysics Data System (ADS)

    Quílez-Pardo, Juan; Solaz-Portolés, Joan Josep

    The aim of this article was to study the reasons, strategies, and procedures that both students and teachers use to solve some chemical equilibrium questions and problems. Inappropriate conceptions on teaching and a lack of knowledge regarding the limited usefulness of Le Chatelier's principle, with its vague and ambiguous formulation and textbook presentation, may be some of the sources of misconceptions about the prediction of the effect of changing conditions on chemical equilibrium. To diagnose misconceptions and their possible sources, a written test was developed and administered to 170 1st-year university chemistry students. A chemical equilibrium problem, relating to the students' test, was solved by 40 chemistry teachers. First, we ascertained that teacher's conceptions might influence the problem-solving strategies of the learner. Based on this first aspect, our discussion also concerns students' and teachers' misconceptions related to the Le Chatelier's principle. Misconceptions emerged through: (a) misapplication and misunderstanding of Le Chatelier's principle; (b) use of rote-learning recall and algorithmic procedures; (c) incorrect control of the variables involved; (d) limited use of the chemical equilibrium law; (e) a lack of mastery of chemical equilibrium principles and difficulty in transferring such principles to new situations. To avoid chemical equilibrium misconceptions, a specific pattern of conceptual and methodological change may be considered.Received: 16 November 1993; Revised: 21 September 1994;

  18. The Adverse Effects of Le Châtelier's Principle on Teacher Understanding of Chemical Equilibrium

    NASA Astrophysics Data System (ADS)

    Cheung, Derek

    2009-04-01

    Although the scientific inadequacy of Le Châtelier's principle has long been documented in the literature, the principle is still treated as a central concept of chemical equilibrium by textbook writers and teachers in many countries. In the past, researchers' interest has focused on student misconceptions about chemical equilibrium and has neglected teacher misconceptions. This study aimed to determine how Le Châtelier's principle adversely affects teachers' ability to solve chemical equilibrium problems. This area of research is critically important because teachers cannot help their students understand what they themselves do not understand. In this study, a misconception test was developed and administered to a sample of 33 secondary chemistry teachers in Hong Kong. The test consisted of three open-ended chemical equilibrium questions. Analysis of teacher responses revealed that most of the 33 teachers failed the test as they relied on Le Châtelier's principle rather than the equilibrium law to tackle the three chemical equilibrium problems. Teachers' misconceptions about chemical equilibrium were categorized. Implications of these findings for chemistry teacher education and selection of curriculum content for school chemistry are discussed.

  19. Mucocèle appendiculaire: à propos d'un cas observé à Lubumbashi

    PubMed Central

    Wakunga, Eric; Mukuku, Olivier; Bugeme, Marcellin; Tshiband, Moïse; Kipili, Audifax; Mobambo, Pitchou; Arung, Willy; Wakunga, Warach

    2014-01-01

    La mucocèle appendiculaire est une entité pathologique rare, mais potentiellement dangereuse, elle se présente sous différentes formes cliniques. Nous rapportons ici un cas d'une patiente âgée de 49 ans sans antécédents chirurgicaux chez qui nous avons découvert d'une façon fortuite cette affection. La clinique était celle d'un syndrome appendiculaire aigu patent et elle révélait une masse dans la fosse iliaque droite. Les examens de laboratoire ont montré une hyperleucocytose et une vitesse de sédimentation augmentée. L’échographie a démontré une masse kystique péricaecal. La patiente a subi une appendicectomie avec cæcectomie partielle et la pièce opératoire appendiculaire mesurait 153 mm de longueur et 64 mm de diamètre. L'analyse anatomopathologique de celle-ci a confirmé le diagnostic de mucocèle appendiculaire sans cellules de malignité. Les suites opératoires ont été simples et la patiente est sortie au cinquième jour postopératoire. PMID:25368725

  20. Contrôle d'une machine asynchrone par estimation robuste de la vitesse

    NASA Astrophysics Data System (ADS)

    Roboam, X.; Hapiot, J. C.; de Fornel, B.; Andrieux, C.

    1992-03-01

    This paper describes the study and the implementation of a variable speed drive for induction motor with no mechanical sensor. Power is supplied by a current-controlled voltage-source inverter. The lack of information (only two line-current sensors) requires an accurate and reliable reconstitution of the main quantities not sensed (flux, speed, torque). The results obtained show the excellent quality of the estimated speed, whatever the operating condition and despite the perturbations applied to the system. This study finally leads to the construction of a prototype. Cet article décrit l'étude et la mise en oeuvre d'un variateur de vitesse pour machine asynchrone sans capteur mécanique et alimentée par un onduleur de tension cotrôlé en courant. Le manque d'information (2 capteurs de courants de ligne uniquement) nécessite la reconstitution fiable et précise des grandeurs fondamentales non mesurées (flux, vitesse, couple). Les résultats obtenus montrent notamment l'excellente qualité de l'estimation de vitesse, quel que soit le point de fonctionnement et en dépit des perturbations auxquelles le système est soumis. Cette étude donne lieu à la réalisation d'un variateur prototype.

  1. Le Fort III distraction osteogenesis: modification of the intraoral splint in the rigid external distraction.

    PubMed

    Lim, Hyoseob; Ko, Ellen Wen-Ching; Lo, Lun-Jou

    2012-05-01

    Le Fort III distraction osteogenesis (DO) is a useful procedure for treating midface hypoplasia. The external distraction system has the advantage of allowing modification of the distraction vector during the activation period. This system needs an intraoral splint for the anchorage points. The intraoral splint has an important role in conducting the distraction force to the midface and in forming the advancement vector. The authors developed a modified type of splint to improve the outcome of Le Fort III DO.The intraoral splint is composed of a modified headgear face bow, molar bands, and a palatal acrylic plate without covering the teeth. Four suspension wires were applied to reinforce the stability. The zygomatic bones and the loops of the splint are selected as 4 anchorage points for Le Fort III DO. This procedure was applied to 2 patients.The midface had an advancement of more than 20 mm in both patients. The dental movement of the upper incisors and the upper first molar was minimal.The dental effect was nearly absent. The amount and vector of distraction could be decided under direct observation without blocking the dental occlusion. The vector of distraction could be adjusted during the activation period. The results of DO were satisfactory.

  2. Cultural Heritage Protection Issues In Leśnica, The Settlement Of Wrocław

    NASA Astrophysics Data System (ADS)

    Kononowicz, Alena

    2015-09-01

    Leśnica, today the settlement on the western edge of Wrocław, formerly was an independent town, located on a previously wooded area, with a linear street system. It developed in the Middle Ages around the castle and church playing a service role for the Silesian Piast court on their way to Legnica and during hunting. In the thirteenth century it received city rights, and lost them in the eighteenth century. After the Piast dynasty had died out, it was sold by John of Luxembourg, and repeatedly changed its owners. In the nineteenth century it developed thanks to the industry, tourism and a convenient railway connection to Wrocław as well as hotel and restaurant facilities. In 1928, Leśnica was incorporated into Wrocław. After the Second World War, it lost its cultural continuity. In the 1970's, middle-heigh and high prefabricated buildings were built in the vicinity of a residential district. At the end of the twentieth and early twenty-first century, local industries were liquidated, and intensive land development started, causing the systematic blurring of its small-town character and its urban space started to acquire a character of a big city. In 2004, the old part of Leśnica was entered in the Register of Monuments. Also a ring road was planned, moving the cumbersome and dangerous transit traffic away from historic Średzka Street beyond the southern border of the settlement.

  3. Stability of Le Fort I Osteotomy With Propeller Graft for Canting Correction in Facial Asymmetry.

    PubMed

    Lee, Jae-Yeol; Kim, Yong-Il; Kang, Hee-Jea; Song, Jae-Min; Park, Soo-Byung; Kim, Jong-Ryoul

    2015-10-01

    The aim of this study was to evaluate the maxillary stability in patients who had undergone Le Fort I osteotomy with propeller graft and mandibular sagittal split ramus osteotomy for correction of maxillary asymmetry. This was a retrospective study on 15 facial asymmetry patients (7 men, 8 women: 22.2 years) requiring surgical correction at the preoperative (T0), immediately postoperative (T1) and 6 months after surgery (T2) stages. To evaluate the skeletal stability, computed tomography (CT) superimposition was used, and skeletal landmarks were measured and compared from the superimposed images according to an x, y, z coordinate system. The skeletal changes at each stage (ΔT1-T0 and ΔT2-T1) were compared by paired t-test (P<0.05). The obtained data on the skeletal changes immediately postoperatively to 6-month follow-up (ΔT2-T1) showed that the Le Fort I osteotomy with propeller graft had effected stable maxillary skeletal stability at the maxillary measurement points (posterior nasal spine (PNS ), nasopalatine canal, U3 crown tip, U3 root apex, and U6 furcation). These results suggested that in cases of facial asymmetry where the upper tooth exposure is proper and anterior-posterior movement of the maxilla is not much required, Le Fort I osteotomy with propeller graft is an effective method for stable canting correction.

  4. Transforming properties of the cottontail rabbit papillomavirus oncoproteins Le6 and SE6 and of the E8 protein.

    PubMed Central

    Harry, J B; Wettstein, F O

    1996-01-01

    Cottontail rabbit papillomavirus induces on cottontail and domestic rabbits papillomas which progress at a high frequency to carcinoma. The virus encodes three transforming proteins; one is translated from open reading frame (ORF) E7 and binds the retinoblastoma protein, and two, LE6 and SE6, are translated from the first and second ATGs of ORF E6, respectively. Here we show that neither of the E6 proteins coprecipitated with p53 in vitro, nor did they bind to a recently identified E6-binding protein (J. J. Chen, C. E. Reid, V. Band, and E. Androphy, Science 269:529-531, 1995). This protein was shown to bind to the E6 proteins of the high-risk human papillomairus types 16 and 18 but not to the low-risk human papillomavirus types VI and II. In-frame deletions cloned into the pZipNeo vector were used to identify structural features of SE6 and LE6 important for transformation of NIH 3T3 cells. Three deletions covering the amino-terminal half of SE6 did not transform cells. In two of the three deletions, two Cys-X-X-Cys motifs were deleted, each deletion preventing the formation of one of the potential small Zn fingers of SE6. Among the LE6 deletions, only one had a reduced transformation efficiency, while seven transformed cells at least as efficiently as wild-type LE6. In each of three of these seven mutants, two Cys-X-X-Cys motifs were deleted. None of the three amino acid deletions which abolished transformation by SE6 reduced transformation by LE6. Furthermore, transformation did not correlate with the level of SE6 or LE6 proteins detectable. ORF E8 colinear with ORF E6, which could generate a 50-amino-acid protein with a hydrophobic segment, did not transform cells when cloned into the pZipNeo vector. However, mutation of the E8 ATG, which did not alter the amino acid sequence of LE6, increased transformation by LE6 without affecting the level of LE6 expression. The data suggest that transformation by the E6 proteins is not mediated by interfering with p53

  5. Profil évolutif et pronostic des tumeurs urothéliales de la vessie chez le sujet jeune

    PubMed Central

    Bouzouita, Abderrazak; Saadi, Ahmed; Kerkeni, Walid; Chakroun, Marouene; Cherif, Mohamed; Ayed, Haroun; Selmi, Selim; Derouiche, Amine; Benslama, Riadh Mohamed; Chebil, Mohamed

    2016-01-01

    Résumé But: Les tumeurs urothéliales de la vessie sont rares chez le jeune adulte. Leur profil évolutif et leur pronostic restent matière à contro-verse. Nous rapportons notre expérience à propos de 54 patients. Méthodologie: Entre 1990 et 2010, 54 patients de moins de 40 ans au moment du diagnostic ont été traités pour carcinome à cellules transitionnelles de la vessie. Nous avons étudié le profil évolutif de ces tumeurs en séparant les patients en deux groupes (moins de 30 ans, et 30 à 40 ans). Résultats: La tumeur n’infiltrait pas le muscle vésical dans 37 cas et l’infiltrait dans 17 cas. Pour les tumeurs n’infiltrant pas le muscle vésical, elles étaient de stade Ta dans 20 cas et de grade I–II dans 36 cas. Le pronostic de ces tumeurs était meilleur avant l’âge de 30 ans avec un taux de récidive de 15,3 % sans progression. Pour les patients de 30 à 40 ans, le taux de récidive était de 33,3 %, et 25 % des tumeurs qui ont récidivé ont présenté une progression du stade. Pour les tumeurs infiltrant le muscle vésical, le pronostic était sombre (localement avancées dans neuf cas et métastatiques d’emblée dans cinq cas). Conclusion: Le profil évolutif des tumeurs n’infiltrant pas le muscle vésical a semblé meilleur avant l’âge de 30 ans. Entre 30 et 40 ans, le profil évolutif s’est approché de celui des sujets âgés. Les tumeurs infiltrantes étaient souvent évoluées et agressives, évoquant un potentiel évolutif particulier. PMID:27330577

  6. Genetic resistance in experimental autoimmune encephalomyelitis. I. Analysis of the mechanism of LeR resistance using radiation chimeras

    SciTech Connect

    Pelfrey, C.M.; Waxman, F.J.; Whitacre, C.C. )

    1989-09-01

    Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated autoimmune disease of the central nervous system that has been extensively studied in the rat. The Lewis rat is highly susceptible to the induction of EAE, while the Lewis resistant (LeR) rat is known to be resistant. In this paper, we demonstrate that the LeR rat, which was derived from the Lewis strain by inbreeding of fully resistant animals, is histocompatible with the Lewis strain. Radiation chimeras, a tool for distinguishing between immunologic and nonimmunologic resistance mechanisms, were utilized to analyze the cellular mechanisms involved in genetic resistance to EAE. By transplanting bone marrow cells from LeR rats into irradiated Lewis recipients, Lewis rats were rendered resistant to EAE induction. Likewise, transplanting Lewis bone marrow cells into irradiated LeR recipients rendered LeR rats susceptible. Mixed lymphoid cell chimeras using bone marrow, spleen, and thymus cells in Lewis recipient rats revealed individual lymphoid cell types and cell interactions that significantly affected the incidence and severity of EAE. Our results suggest that LeR resistance is mediated by hematopoietic/immune cells, and that cells located in the spleen appear to play a critical role in the resistance/susceptibility to EAE induction. Depletion of splenic adherent cells did not change the patterns of EAE resistance. In vivo cell mixing studies suggested the presence of a suppressor cell population in the LeR spleen preparations which exerted an inhibitory effect on Lewis autoimmune responses. Thus, the mechanism of LeR resistance appears to be different from that in other EAE-resistant animals.

  7. Considérations nosographiques sur le délire d'infestation parasitaire à travers trois observations cliniques

    PubMed Central

    Berhili, Nabil; Bout, Amine; Hlal, Hayat; Aarab, Chadya; Aalouane, Rachid; Rammouz, Ismail

    2016-01-01

    Le syndrome d'Ekbom, ou délire d'infestation parasitaire, est une pathologie rare, caractérisée par la conviction inébranlable d'avoir une peau infestée d'insectes ou de parasites. Il s'agit d'un délire monothématique à mécanisme hallucinatoire qui touche typiquement les femmes d’âge avancé. Nous rapportons les cas de trois patients qui présentent un délire d'infestation parasitaire dans des contextes cliniques différents. Le premier patient souffre d'un délire d'infestation isolé correspondant à la forme décrite par Karl Ekbom. Le deuxième cas présente un délire d'infestation secondaire, s'inscrivant dans le cadre d'une leuco-encéphalopathie de type CADASIL. Enfin, le troisième patient se présente dans un tableau évocateur d'un épisode dépressif avec une caractéristique psychotique qui intègre le délire d'infestation. Ces trois vignettes cliniques illustrent parfaitement le caractère trans-nosographique de ce syndrome ainsi que les difficultés de prise en charge de ces patients, tant au niveau de l'alliance thérapeutique que sur le plan des choix en matière de traitement pharmacologiques. PMID:27642468

  8. Troubles psychotiques précipités par le mariage : étude de trois observations

    PubMed Central

    Jaweher, Masmoudi; Kammoun, Mohamed Faouzi; Inès, Feki; Imen, Baati; Rim, Sallami; Abdelaziz, Jaoua

    2013-01-01

    Le mariage est un évènement très investi dans notre culture arabo-musulmane. Il présente une situation à grande charge émotionnelle et ayant un vécu stressant. C'est ainsi qu'il peut être à l'origine de la décompensation de certains troubles psychiatriques. Ce moment particulier de déclenchement de la pathologie peut altérer significativement l'adaptation familiale et sociale du patient en question, le rendant dépendant en partie ou en totalité à une institution. Dans ce travail, nous proposons d’étudier certains facteurs psychiques, sociaux et culturels pouvant aboutir à la précipitation des manifestations psychotiques par le mariage. Il s'agit de l’étude de trois observations cliniques, deux hommes et une femme, hospitalisés dans le service de psychiatrie A du CHU Hédi Chaker de Sfax et qui ont développés des manifestations psychotiques de façon concomitante à leur mariage. La durée moyenne de survenue des crises a été de vingt ans, le diagnostic retenu a été celui de trouble bipolaire dans deux cas et d'une schizophrénie indifférenciée chez le troisième patient. L’évolution s'est faite vers une chronicisation de deux malades et une dépendance institutionnelle dans le troisième cas. La précipitation des troubles psychotiques par le mariage, reste un phénomène en relation intime avec les composantes culturelles, elles-mêmes sont déterminantes dans la prise en charge ultérieure de ces patients. PMID:23785551

  9. Cloning, characterization and effect of TmPGRP-LE gene silencing on survival of Tenebrio molitor against Listeria monocytogenes infection.

    PubMed

    Tindwa, Hamisi; Patnaik, Bharat Bhusan; Kim, Dong Hyun; Mun, Seulgi; Jo, Yong Hun; Lee, Bok Luel; Lee, Yong Seok; Kim, Nam Jung; Han, Yeon Soo

    2013-01-01

    Peptidoglycan recognition proteins (PGRPs) are a family of innate immune molecules that recognize bacterial peptidoglycan. PGRP-LE, a member of the PGRP family, selectively binds to diaminopimelic acid (DAP)-type peptidoglycan to activate both the immune deficiency (Imd) and proPhenoloxidase (proPO) pathways in insects. A PGRP-LE-dependent induction of autophagy to control Listeria monocytogenes has also been reported. We identified and partially characterized a novel PGRP-LE homologue, from Tenebrio molitor and analyzed its functional role in the survival of the insect against infection by a DAP-type PGN containing intracellular pathogen, L. monocytogenes. The cDNA is comprised of an open reading frame (ORF) of 990 bp and encodes a polypeptide of 329 residues. TmPGRP-LE contains one PGRP domain, but lacks critical residues for amidase activity. Quantitative RT-PCR analysis showed a broad constitutive expression of the transcript at various stages of development spanning from larva to adult. RNAi mediated knockdown of the transcripts, followed by a challenge with L. monocytogenes, showed a significant reduction in survival rate of the larvae, suggesting a putative role of TmPGRP-LE in sensing and control of L. monocytogenes infection in T. molitor. These results implicate PGRP-LE as a defense protein necessary for survival of T. molitor against infection by L. monocytogenes. PMID:24240808

  10. le hydatiforme partielle invasive et métastatique: à propos d'un cas

    PubMed Central

    Lazrak, Ikram; Ihssane, Hakimi; Babahabib, Moulay Abdellah; Kouach, Jaouad; El Ochi, Mohamed Reda; Moussaoui, Moulay Driss; Dehayni, Mohamed

    2014-01-01

    Depuis plusieurs années, la môle hydatiforme partielle(MHP) a été considérée comme une entité bénigne qui ne nécessite pas une surveillance stricte comme celle de la môle complète(MC), mais l'apparition de quelques cas sporadiques de transformation de la môle partielle en maladie trophoblastique persistante que ça soit une môle invasive ou choriocarcinome ou voire même une tumeur du site d'implantation placentaire; a remis en question cette stratégie. A travers une observation d'une môle partielle invasive métastatique, et à travers une revue de la littérature, on a essayé d'appuyer cette conduite qui considère la môle partielle comme une pathologie potentiellement grave nécessitant une prise en charge adéquate et une surveillance assez rigoureuse. PMID:25815096

  11. Le cancer en Mauritanie : résultats sur 10 ans du registre hospitalier de Nouakchott

    PubMed Central

    Baba, Nacer Dine Ould Mohamed; Sauvaget, Catherine

    2013-01-01

    Le fardeau du cancer reste mal connu en Mauritanie. Il n'est basé que sur des extrapolations de l'incidence des cancers des pays avoisinants. Les données du registre de l'hôpital national permettent de décrire les cas avec un diagnostic histologique. Tous les cas de cancers enregistrés par le service d'anatomo-pathologie de l'hôpital national de Nouakchott de 2000 à 2009 ont été analysés. En 10 ans, 3305 prélèvements histologiques ont été analysés (hommes:42%, femmes:58%). Chez l'homme, le cancer le plus fréquemment analysé était le cancer de la peau (218 cas au total, 189 cas en excluant mélanome), suivi de la prostate (203), des cancers digestifs (179, colorectal et ‘sophage), et des lymphomes (151). Chez la femme, un quart des biopsies était des cancers du sein (485), suivi du col utérin (344), de la sphère gynécologique (218, ovaire et corps utérin), et de la peau (114). Les cancers du foie, du poumon ou de la vessie étaient peu fréquents. Ces résultats ne reflètent pas l'incidence ni l'actuel fardeau du cancer en Mauritanie puisque de nombreux patients diagnostiqués avec un cancer ne reçoivent pas d'examen anatomopathologique. Si, comme dans les pays avoisinants du Maroc et du Mali, les cancers du col et du sein sont les pathologies les plus fréquentes chez la femme, la distribution des cancers chez l'homme dans ce registre hospitalier diffère des résultats des registres de population du Maroc et du Mali où les cancers du poumon, du foie, de la prostate et de la vessie dominent. PMID:23785554

  12. Programmable lithography engine (ProLE) grid-type supercomputer and its applications

    NASA Astrophysics Data System (ADS)

    Petersen, John S.; Maslow, Mark J.; Gerold, David J.; Greenway, Robert T.

    2003-06-01

    There are many variables that can affect lithographic dependent device yield. Because of this, it is not enough to make optical proximity corrections (OPC) based on the mask type, wavelength, lens, illumination-type and coherence. Resist chemistry and physics along with substrate, exposure, and all post-exposure processing must be considered too. Only a holistic approach to finding imaging solutions will accelerate yield and maximize performance. Since experiments are too costly in both time and money, accomplishing this takes massive amounts of accurate simulation capability. Our solution is to create a workbench that has a set of advanced user applications that utilize best-in-class simulator engines for solving litho-related DFM problems using distributive computing. Our product, ProLE (Programmable Lithography Engine), is an integrated system that combines Petersen Advanced Lithography Inc."s (PAL"s) proprietary applications and cluster management software wrapped around commercial software engines, along with optional commercial hardware and software. It uses the most rigorous lithography simulation engines to solve deep sub-wavelength imaging problems accurately and at speeds that are several orders of magnitude faster than current methods. Specifically, ProLE uses full vector thin-mask aerial image models or when needed, full across source 3D electromagnetic field simulation to make accurate aerial image predictions along with calibrated resist models;. The ProLE workstation from Petersen Advanced Lithography, Inc., is the first commercial product that makes it possible to do these intensive calculations at a fraction of a time previously available thus significantly reducing time to market for advance technology devices. In this work, ProLE is introduced, through model comparison to show why vector imaging and rigorous resist models work better than other less rigorous models, then some applications of that use our distributive computing solution are shown

  13. Le potentiel de l'asteroseismologie pour les etoiles sous-naines de type B

    NASA Astrophysics Data System (ADS)

    Charpinet, Stephane

    L'objectif principal de cette thèse consiste à évaluer les possibilités que les étoiles sous naines de type B, aussi appelées sdB, puissent développer des variations de luminosité engendrées par des phénomènes de pulsations. Dans la mesure où, au commencement de cette étude, les sdB ne sont pas connues pour montrer ce type de comportement, notre approche s'effectue exclusivement sur des bases théoriques visant à déterminer, par le calcul, si ces étoiles ont le potentiel pour devenir instables. Le cas échéant, il s'agira d'évaluer quels sont les résultats susceptibles d'émerger d'un sondage de la structure interne de ces étoiles avec les méthodes de l'astéroséismologie. Après avoir introduit le contexte et les outils théoriques nécessaires à ce projet (théorie des pulsations stellaires et modèles d'étoiles sous-naines de type B), la démarche passe obligatoirement par une étude exhaustive des propriétés des modes de pulsation dans ces étoiles. Nous l'avons entreprise de manière systématique afin d'évaluer et de comprendre les comportements des oscillations en fonction des différents paramètres physiques qui caractérisent une sdB. Par souci de complétude, nous étudions également les rapports qu'entretiennent évolution et périodes de pulsation au cours de la phase sdB. Par la suite, fort des connaissances nouvellement acquises, nous nous lançons dans l'étude de la stabilité des modes d'oscillation, l'objectif étant d'identifier, le cas échéant, un mécanisme capable de déstabiliser, dans certaines conditions, une fraction de ces étoiles. Par cette approche, nous déterminons qu'un mécanisme κ associé à une région d'ionisation partielle de l'élément fer agit efficacement dans l'enveloppe des sdB si, toutefois, le fer y est présent en quantités extra- solaires. Nous montrons alors que des processus de diffusion, déjà fortement suspectes d'exister dans ces étoiles, sont en mesure d'accumuler des quantit

  14. Le Conte's sparrows breeding in Conservation Reserve Program fields: precipitation and patterns of population change

    USGS Publications Warehouse

    Igl, Lawrence D.; Johnson, Douglas H.

    1999-01-01

    The climate of the North American Great Plains is highly dynamic, with great year-to-year variability in precipitation and periodic, often extreme, wet and dry cycles (Bragg 1995). Drought is a major force of ecological disturbance on the Great Plains and has played a key role in directing the evolution of the grassland biota of this region (Knopf and Samson 1997). Although grassland birds may differ in their responses to enviromenental variations (Rotenberry and Wiens 1991), climatic variability and concomitant unpredictability of resources strongly influence populations of grassland birds across space and time (Wiens 1974, 1986; Cody 1985). Not surprisingly, breeding bird populations on the Great Plains are highly dynamic, exhibiting considerable annual variation in composition, abundance, and distribution (Johnson and Grier 1988, George et al. 1992, Zimmerman 1992, Igl and Johnson 1997). Recently, interest in grassland birds has increased with the recognition that many species are declining both continentally (Droege and Sauer 1994) and globally (Goriup 1988). Identification of the specific factors associated with grassland bird declines in North America, however, remains largely enigmatic (Herkert 1997), and it is complicated by the considerable annual fluctuations in grassland bird distribution and abundance (Igl and Johnson 1997). Although there is evidence that land-use changes on the breeding grounds may have contributed to grassland bird declines (e.g., Igl and Johnson 1997), there also is an indication that long-term drought conditions may have influenced recent population changes of some breeding birds on the Great Plains (Droege and Sauer 1989, Peterjohn and Sauer 1993, Bethke and Nudds 1995, Igl and Johnson 1997). Le Conte's Sparrow (Ammodramus leconteii) is a secretive grassland bird that breeds in central and southern Canada and the northcentral United States (Murray 1969). It winters primarily in the southern United States (Peterson 1980, 1990

  15. Etude de la Production des Mesons d* Sur le PIC de Resonance du Boson Z Observes AU Lep avec le Detecteur Opal

    NASA Astrophysics Data System (ADS)

    Przysiezniak, Helenka

    L'etude de la production des mesons D* est effectuee a partir d'evenements multihadroniques rm Z^0to q| q, avec des donnees prises en 1990, 1991 et 1992 avec le detecteur OPAL au LEP. La notation q definit les quarks des cinq saveurs pouvant etre observees au LEP: up (u), down (d), strange (s), charme (c), beaute (b). Les D* et les correlations D*-leptons sont identifiees et ces dernieres servent a effecteur une separation claire entre les evenements rm Z^0to b| b et Z^0to c| c. On mesure la distribution de la variable de fragmentation x_{rm D^ *}=E_{rm D^*}/E _{rm faisceau} pour les D* produits dans les evenements rm Z^0 to c| c. Elle est notee f _{rm cto D^*}. Ce resultat est a la base d'une publication OPAL (1), avec trois autres methodes de separation etudiees en parallele, donnat la premiere mesure OPAL de f _{rm cto D^*} qui soit independante de toute modelisation de la fragmentation des quarks lourds, ainsi qu'une mesure de Gamma_{rm c| c} parmi les plus precises effectuees a ce jour, ou Gamma_{rm c| c} est la largeur partielle de la desintegration du Z^0 en une paire cc. En ce qui concerne les resultats obtenus dans le cadre de cette these, la valeur moyenne de la distribution f_ {rm cto D^*}, notee < x_{rm cto D^*}>, est donnee par:< x_{rm cto D^*}>=0.530+/-0.027 +/-0.022ou la premiere erreur est statistique, et la seconde est systematique. On mesure aussi le taux de production des mesons D*, donnee par: {Gamma({rm Z^0to D^ *}X)overGamma_{rm hadrons}}=0.207+/-0.007+/-0.017 ou Gamma_{rm hadrons } est la largeur totale de la desintegration du Z^0 en paires de qq des cinq saveurs. La separation entre evenements rm Z^0to b| b et Z^0 to c| c, dans lesquels sont produits des D* se desintegrant selon rm D^ *to D^0pito (Kpi)pi, nous donne:(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI)La variable de fragmentation x_ {rm cto D^*} est utilisee pour tester les modeles des processes perturbatifs et non-perturbatifs qui entrent en jeu lors de la fragmentation des

  16. Les accidents de scooter chez l'enfant au CHU Aristide Le Dantec de Dakar: à propos de 74 cas

    PubMed Central

    Mohamed, Azhar Salim; Ngom, Gabriel; Sow, Mamadou; Mbaye, Papa Alassane; Camara, Souleymane; Seck, Ndeye Fatou; Ndour, Oumar

    2016-01-01

    Introduction Les accidents de scooter sont de plus en plus fréquents à Dakar. Le but de ce travail est de rapporter les aspects épidémiologiques et lésionnels des ces accidents chez l'enfant à Dakar. Méthodes Une étude rétrospective et descriptive a été menée dans le Service de Chirurgie Pédiatrique du CHU Aristide Le Dantec de Dakar entre le 1er janvier 2009 et le 31 décembre 2011. Nous avons étudié divers paramètres dont la fréquence, les aspects sociodémographiques et lésionnels. Résultats Les accidents de scooter représentaient 12% des accidents de la voie publique. Ils étaient fréquents entre 12 heures et 14 heures (27%) et entre 18 heures et 20 heures (28,4%). Ils pouvaient survenir tous les jours et étaient fréquents pendant les mois d'avril (17,6%) et de juin (13,5%). Ils survenaient essentiellement dans la périphérie de Dakar (78%). La tranche de 3 à 8 ans (60,8%) était la plus touchée. Le sexe masculin était prédominant (sexe ratio de 1,5). Les piétons étaient les plus vulnérables (93,2%). La chute était le mécanisme dominant (98,7%). Les lésions touchaient surtout le membre inférieur (51,1%) et étaient constituées essentiellement de fracture. Conclusion La fréquence des accidents de scooter chez l'enfant est liée à l'urbanisation galopante et à l'accroissement du parc automobile dans une presqu’île. Les victimes sont essentiellement des piétons et présentent le plus souvent des fractures. PMID:27200137

  17. Le traitement conservateur du cancer du sein: expérience d'une équipe tunisienne

    PubMed Central

    Dimassi, Kaouther; Gharsa, Anissa; Chanoufi, Mohammed Badis; Sfar, Ezzeddine; Chelli, Dalenda

    2014-01-01

    En Tunisie, le cancer du sein touche des femmes jeunes avec une taille moyenne au moment du diagnostic à 5 cm. Ces particularités font que la chirurgie radicale reste prédominante. Nous présentons dans ce travail l'expérience de notre équipe en matière de chirurgie conservatrice du cancer du sein. Le but de ce travail est d’évaluer les résultats de ce traitement. Etude rétrospective longitudinale, sur une période de 75 mois. Nous avons inclus toutes les patientes ayant bénéficié d'un traitement conservateur pour une tumeur maligne du sein. Ont été analysés: les caractéristiques épidémiologiques, les aspects radiologiques et histologiques. Le suivi des malades s'est basé sur la détection des récidives. Nous avons évalué le résultat esthétique à la fin de la radiothérapie. Le traitement conservateur a été réalisé dans 23.8% des cas. Le taux de récidives locales était de 6.8% avec une corrélation significative pour une taille tumorale > 30 mm (p= 0.009), l'association d'une composante intracanalaire (p= 0.035), le statut triple négatif (p= 0.003) et des marges d'exérèse < 5mm sans recoupes per-opératoires (p = 0.045). Les facteurs suivants étaient significativement liés au risque de survenue de métastases à distance: le statut triple négatif (p= 0.003), taille tumorale > 30mm (p = 0.006) et l'atteinte ganglionnaire (p = 0.001). Le résultat esthétique était satisfaisant dans 90% des cas. L'augmentation du nombre de patientes pouvant bénéficier d'une chirurgie conservatrice, doit passer impérativement par le développement et la promotion du diagnostic précoce et du dépistage par la mammographie. PMID:25810795

  18. Contrôle de l'orientation et de l'alignement moléculaire par un train d'impulsions soudaines

    NASA Astrophysics Data System (ADS)

    Sugny, D.

    2006-10-01

    Les récents progrès technologiques dans le domaine des Lasers permettent d'envisager le contrôle de nombreux processus quantiques jouant un rôle dans une variété de problèmes s'étendant de la réactivité chimique à l'information quantique. Dans ce contexte, nous nous sommes intéressés au contrôle de l'orientation ou de l'alignement moléculaire en utilisant un train d'impulsions soudaines. Nous avons défini des états cibles qui maximisent à la fois l'orientation ou l'alignement et sa durée dans le temps et montré comment atteindre ces états à l'aide de stratégie systématique ou optimisée

  19. Le domaine des co-infections et des maladies concomitantes du Réseau canadien pour les essais VIH des IRSC : lignes directrices canadiennes pour la prise en charge et le traitement de la co-infection par le VIH et l’hépatite C chez les adultes

    PubMed Central

    Hull, Mark; Giguère, Pierre; Klein, Marina; Shafran, Stephen; Tseng, Alice; Côté, Pierre; Poliquin, Marc; Cooper, Curtis

    2014-01-01

    HISTORIQUE : De 20 % à 30 % des Canadiens qui vivent avec le VIH sont co-infectés par le virus de l’hépatite C (VHC), lequel est responsable d’une morbidité et d’une mortalité importantes. La prise en charge du VIH et du VHC est plus complexe en raison de l’évolution accélérée de la maladie hépatique, du choix et des critères d’initiation de la thérapie antirétrovirale et du traitement anti-VHC, de la prise en charge de la santé mentale et des toxicomanies, des obstacles socioéconomiques et des interactions entre les nouvelles thérapies antivirales à action directe du VHC et les antirétroviraux OBJECTIF : Élaborer des normes nationales de prise en charge des adultes co-infectés par le VHC et le VIH dans le contexte canadien. MÉTHODOLOGIE : Le Réseau canadien pour les essais VIH des Instituts de recherche en santé du Canada a réuni un groupe d’experts possédant des compétences cliniques en co-infection par le VIH et le VHC pour réviser les publications à jour ainsi que les lignes directrices et les protocoles en place. Après une vaste sollicitation afin d’obtenir des points de vue, le groupe de travail a approuvé des recommandations consensuelles, qu’il a caractérisées au moyen d’une échelle de qualité des preuves fondée sur la classe (bienfaits par rapport aux préjudices) et sur la catégorie (degré de certitude). RÉSULTATS : Toutes les personnes co-infectées par le VIH et le VHC devraient subir une évaluation en vue de recevoir un traitement du VHC. Les personnes qui ne sont pas en mesure d’entreprendre un traitement du VHC devraient être soignées pour le VIH afin de ralentir l’évolution de la maladie hépatique. La norme de traitement du VHC de génotype 1 est un régime comprenant de l’interféron pégylé et de la ribavirine dosée en fonction du poids, associés à un inhibiteur de la protéase du VHC. Pour les génotypes 2 ou 3, une bithérapie classique est recommandée pendant 24 semaines s

  20. An Integrated Sediment Budget for the Le Sueur River in Southern Minnesota

    NASA Astrophysics Data System (ADS)

    Day, S. S.; Belmont, P.; Perg, L.; Johnson, A.; Gran, K.; Jennings, C.; Wilcock, P.

    2007-12-01

    The Le Sueur River is the primary sediment contributor to the Minnesota River, which is impaired by sediment under the Clean Water Act. The necessary first step toward developing a watershed management plan is identifying sediment sources and sinks throughout the basin. The focus of this study is to quantify the contribution of sediment from different sources in order to understand the broader problems affecting the larger Minnesota Basin. The lower Le Sueur River is actively incising in response to late Pleistocene baselevel fall on the Minnesota River, a result of the catastrophic draining of glacial Lake Agassiz. Potential sediment sources along the Le Sueur include high bluffs composed of highly consolidated Pre-Illinoisian, Illinoisian and Wisconsinin till and alluvial sediment, growing ravines and gullies, sediment exchange between the active channel and floodplains, as well as upland agricultural fields, which account for over 90% of the land surface. We applied side-scanning LiDAR to quantify the amount of sediment being eroded from the high bluffs and banks. To understand meander migration rates as well as ravine and gully retreat rates, and to supplement the understanding of bluff retreat rates, we have used aerial LiDAR along with comparative analysis of historic aerial orthophotos. The aerial LiDAR will also be used to calculate the volume of sediment being stored in the floodplains and terraces along the river, which will be used to create a floodplain exchange model. Preliminary results indicate that bluff retreat rates could be as high as 0.4 meters per year and meander bend migration rates up to 3 meters per year in isolated reaches of the watershed. Data collected from each potential source will be combined to create an overall sediment routing model for the watershed.

  1. Le léiomyome vésical : À propos de 5 cas

    PubMed Central

    Saadi, Ahmed; Bouzouita, Abderrazak; Cherif, Mohamed; Ayed, Haroun; Derouiche, Amine; Ben Slama, Riadh Mohamed; Chebil, Mohamed

    2015-01-01

    Résumé Introduction : Les léiomyomes sont des tumeurs mésenchymateuses bénignes. La localisation vésicale de ces tumeurs est rare et représente moins de 0,5 % de toutes les tumeurs vésicales. Le léiomyome vésical est la plus fréquente de ces tumeurs mésenchymateuses et il représente le tiers des lésions bénignes de la vessie. Notre but était d’étudier les particularités épidémiologiques, cliniques, radiologiques, thérapeutiques et évolutives de ce type de tumeur. Matériel et méthodes : Nous rapportons une série de cinq cas de léiomyome vésical, colligés entre 2001 et 2014. Il s’agit de trois femmes et de deux hommes. La symptomatologie clinique est non spécifique et dominée par la cystite. Trois patients ont eu une énucléation et deux ont eu une résection endoscopique de la tumeur. Résultats : Le suivi moyen est de six ans. Un seul patient a présenté une récidive expliquée par la persistance d’un nodule vésical lors de la première intervention, avec une bonne évolution après la deuxième cure chirurgicale. Conclusion : Le léiomyome vésical est une tumeur bénigne et rare. Sa symptomatologie est peu spécifique. Son diagnostic est histologique. Son traitement est toujours chirurgical, offrant un excellent pronostic, sous réserve d’une exérèse complète pour éviter les récidives. PMID:26279718

  2. Critical Dynamics of Burst Instabilities in the Portevin-Le Chatelier Effect

    SciTech Connect

    D'Anna, Gianfranco; Nori, Franco

    2000-11-06

    We investigate the Portevin-Le Chatelier effect (PLC), by compressing Al-Mg alloys in a very large deformation range, and interpret the results from the viewpoint of phase transitions and critical phenomena. The system undergoes two dynamical phase transitions between intermittent (or ''jerky'') and ''laminar'' plastic dynamic phases. Near these two dynamic critical points, the order parameter 1/{tau} of the PLC effect exhibits large fluctuations, and ''critical slowing down'' (i.e., the number {tau} of bursts, or plastic instabilities, per unit time slows down considerably).

  3. Investigation of Portevin-Le Chatelier band with temporal phase analysis of speckle interferometry

    NASA Astrophysics Data System (ADS)

    Jiang, Zhenyu; Zhang, Qingchuan; Wu, Xiaoping

    2003-04-01

    A new method combining temporal phase analysis with dynamic digital speckle pattern interferometry is proposed to study Portevin-Le Chatelier effect quantitatively. The principle bases on that the phase difference of interference speckle patterns is a time-dependent function related to the object deformation. The interference speckle patterns of specimen are recorded with high sampling rate while PLC effect occurs, and the 2D displacement map of PLC band and its width are obtained by analyzing the displacement of specimen with proposed method.

  4. The effects of Le Fort I osteotomy with maxillary movement on articulation, resonance, and velopharyngeal function.

    PubMed

    Kummer, A W; Strife, J L; Grau, W H; Creaghead, N A; Lee, L

    1989-07-01

    Articulation, resonance, and velopharyngeal function were evaluated before and after Le Fort I maxillary advancement in 16 patients (seven with cleft lip and palate, one with cleft lip only, and eight without clefts). On the postoperative evaluation, seven of 11 patients with preoperative articulation errors showed an improvement in articulation after surgery. Two patients without clefts showed slight changes in nasal resonance, and two patients (one with cleft lip and palate and one with cleft lip only) developed mild nasal emission. Nine patients showed diminished velopharyngeal contact during speech on videofluoroscopic studies. Compensatory changes in velopharyngeal function were also observed, which included velar stretching and lengthening and increased lateral pharyngeal wall movement.

  5. Intubation Difficile Chez le Brule de la Face et du Cou a la Phase de Sequelles

    PubMed Central

    Siah, S.; El Wali, A.; Ababou, K.; Nassim Sabah, T.; Drissi, N.K.; Ihrai, I.

    2006-01-01

    Summary L'intubation trachéale chez le brûlé de la face et du cou au stade de séquelles peut être difficile voire impossible chez certains patients. La technique de ventilation à l'aide d'un masque laryngé ou d'intubation avec un fibroscope bronchique permet de résoudre la plupart des problèmes d'intubation difficile. Les Auteurs rapportent deux observations chez deux patientes porteuses de séquelles de brûlures de la face et du cou. PMID:21991028

  6. Apport de l'imagerie dans le diagnostic des sacroiliites infectieuses : à propos de 19 cas

    PubMed Central

    Abid, Hanen; Chaabouni, Salim; Frikha, Faten; Toumi, Nozha; Souissi, Basma; Lahiani, Dorra; Bahloul, Zouhir; Ben Mahfoudh, Khaireddine

    2014-01-01

    Les sacro-iliites infectieuses méritent d’être mieux connues. Leur diagnostic est souvent retardé en raison d'une symptomatologie trompeuse et des diffcultés d'exploration de l'articulation sacro-iliaque. Notre travail est basé sur une étude rétrospective portant sur les cas de SII, recueillis sur une période comprise entre 1997 et 2008 dans notre centre universitaire Sfax-Tunisie. Le diagnostic de sacro-iliite était retenu en présence d'arguments cliniques et radiologiques d'atteinte sacroiliaque. Nous rapportons dix neuf cas de sacroiliites infectieuses (10 hommes et 9 femmes), avec un âge moyen de 32 ans. L'atteinte était unilatérale dans tous les cas. Les radiographies standard faites dans tous les cas ont été suggestives dans 14 cas et normales dans les autres cas. La TDM faite dans 13 cas a montré, un abcès des parties molles dans 8 cas et un séquestre osseux dans 2 cas. L'IRM réalisée dans 8 cas, a objectivé une infiltration des parties molles dans tous les cas et un abcès dans 3 cas. Le germe a été identifié dans 9 cas (3 cas de tuberculose, 3 cas de brucellose, 2 sacro-iliites à pyogène et un cas de candidose). Cette identification était faite par biopsie dans 3 cas, hémocultures dans 2 cas, prélèvement au niveau de la porte d'entrée dans 1 cas et sérodiagnostic dans 3 cas. Pour les autres cas, l'origine pyogène a été retenue sur des arguments cliniques et biologiques. L'imagerie joue un rôle primordial dans le diagnostic précoce et l'orientation étiologique d'une sacroiliite infectieuse. PMID:25120884

  7. Factors controlling growth and morphology of early Miocene stromatolites from Montaigu-le-Blin, France

    NASA Astrophysics Data System (ADS)

    Bontognali, Tomaso R. R.; Barilaro, Federica; McKenzie, Judith A.; Vasconcelos, Crisogono

    2015-04-01

    A large variety of stromatolite morphotypes are present in the early Miocene sedimentary sequence that outcrops in the region of Montaigu-le-Blin, France. Thanks to its good degree of preservation, this formation is an ideal place to evaluate the key factors controlling the occurrence and morphology of the stromatolites, as well as to study the diagenetic processes that transform a soft, slimy lithifying microbialite into a solid, laminated sedimentary rock. Facies analysis suggests that the Montaigu-le-Blin stromatolites formed in shallow waters, in a restricted, laterally heterogeneous basin. Various evidence suggests a biological origin for the stromatolites, whose formation cannot be explained through abiotic background precipitation driven by evaporation, temperature changes, or migration of metamorphic fluids. Microscopic observations revealed that the Montaigu-le-Blin stromatolites are mainly comprised of authigenic calcite that precipitated directly from the basin waters (no evidence for trapping and binding) in close association with algae, microbial cells, and exopolymeric substances. Well-preserved microfossils of photosynthetic organisms are widespread within the thin sections. The calcite constituting the stromatolites is characterized by positive δ13C values (1.7 to 4.4 o), suggesting that microbial mediation of calcite was mainly related to the metabolic activity of photosynthetic organisms or anoxygenic phototrophs, and not to metabolisms in which organic material is degraded (e.g. sulfate reduction). The laminated habit of the stromatolites results from alternating layers of porous, digit-like sparite and more compacted organic-rich micrite. No correlation was identified, through isotopic analysis, between these two types of laminae and external environmental factors (i.e. temperature, salinity, eutrophication state). Rather, we hypothesize that periodic fluctuations in the dominant microbial/algal species within the mat influenced the morphology

  8. Natural or controlled experiment? Disentangling anthropogenic and geologic contributions to the sediment load of the Le Sueur River, MN, USA

    NASA Astrophysics Data System (ADS)

    Finnegan, N. J.; Gran, K. B.

    2012-12-01

    Catastrophic draining of glacial Lake Agassiz at the end of the Pleistocene triggered a pulse of incision along the Minnesota River, MN, USA, that is currently propagating into tributary channels and elevating channel incision rates far above regional background levels. At the same time, installation of artificial drainage to remove excess soil water (tiling) in tributaries of the Minnesota has resulted in shorter and higher amplitude hydrographs during spring snow melt and storm events. Thus both natural and anthropogenic explanations exist for high sediment loads from tributaries to the Minnesota River, among them the Le Sueur River, which is currently impaired for turbidity under EPA Clean Water Act standards. Here we investigate the transient incision history of the Le Sueur River to aid in the development of Total Maximum Daily Loads (TMDLs) for sediment in the Le Sueur. Establishing TMDLs for the Le Sueur requires separation of anthropogenic and geologic contributions to current sediment loads. Towards this end, we ran a series of numerical simulations of the excavation of the Le Sueur River valley over the Holocene in order to constrain pre-settlement rates of sediment export. Our approach relies on coupling (with varying strength) a 2D numerical model for river meandering to various 1D numerical models for river incision. Fortuitously, both the initial profile of the Le Sueur (prior to the flood from Lake Agassiz) as well as the timing of the flood itself can be reasonably constrained from LiDAR data and previous Quaternary studies, respectively. Additionally, LiDAR-mapping of discontinuous, unpaired strath terraces combined with OSL and/or 14C dates on 18 strath terrace deposits pin pieces of the long profile of the Le Sueur River in time and space. By minimizing the model misfit for strath terrace ages, the current river elevation long profile, and the width between bluffs along the Le Sueur River valley, we identify a preferred valley excavation history

  9. Characterization of LeMir, a root-knot nematode-induced gene in tomato with an encoded product secreted from the root.

    PubMed

    Brenner, E D; Lambert, K N; Kaloshian, I; Williamson, V M

    1998-09-01

    A tomato gene that is induced early after infection of tomato (Lycopersicon esculentum Mill.) with root-knot nematodes (Meloidogyne javanica) encodes a protein with 54% amino acid identity to miraculin, a flavorless protein that causes sour substances to be perceived as sweet. This gene was therefore named LeMir (L. esculentum miraculin). Sequence similarity places the encoded protein in the soybean trypsin-inhibitor family (Kunitz). LeMir mRNA is found in root, hypocotyl, and flower tissues, with the highest expression in the root. Rapid induction of expression upon nematode infection is localized to root tips. In situ hybridization shows that LeMir is expressed constitutively in the root-cap and root-tip epidermis. The LeMir protein product (LeMir) was produced in the yeast Pichia pastoris for generation of antibodies. Western-blot analysis showed that LeMir expression is up-regulated by nematode infection and by wounding. LeMir is also expressed in tomato callus tissue. Immunoprint analysis revealed that LeMir is expressed throughout the seedling root, but that levels are highest at the root/shoot junction. Analysis of seedling root exudates revealed that LeMir is secreted from the root into the surrounding environment, suggesting that it may interact with soil-borne microorganisms. PMID:9733543

  10. Dimensions of Velopharyngeal Space following Maxillary Advancement with Le Fort I Osteotomy Compared to Zisser Segmental Osteotomy: A Cephalometric Study.

    PubMed

    Karabekmez, Furkan Erol; Kleinheinz, Johannes; Jung, Susanne

    2015-01-01

    The objectives of this study are to assess the velopharyngeal dimensions using cephalometric variables of the nasopharynx and oropharynx as well as to compare the Le Fort I osteotomy technique to Zisser's anterior maxillary osteotomy technique based on patients' outcomes within early and late postoperative follow-ups. 15 patients with severe maxillary deficiency treated with Le Fort I osteotomy and maxillary segmental osteotomy were assessed. Preoperative, early postoperative, and late postoperative follow-up lateral cephalograms, patient histories, and operative reports are reviewed with a focus on defined cephalometric landmarks for assessing velopharyngeal space dimension and maxillary movement (measured for three different tracing points). A significant change was found between preoperative and postoperative lateral cephalometric measurements regarding the distance between the posterior nasal spine and the posterior pharyngeal wall in Le Fort I osteotomy cases. However, no significant difference was found between preoperative and postoperative measurements in maxillary segmental osteotomy cases regarding the same measurements. The velopharyngeal area calculated for the Le Fort I osteotomy group showed a significant difference between the preoperative and postoperative measurements. Le Fort I osteotomy for advancement of upper jaw increases velopharyngeal space. On the other hand, Zisser's anterior maxillary segmental osteotomy does not alter the dimension of the velopharyngeal space significantly.

  11. Postoperative stability following maxillary downward movement with Le Fort I inclined osteotomy at the lateral nasal cavity wall.

    PubMed

    Yang, Hoon Joo; Hwang, Soon Jung

    2012-12-01

    Downward movement of the maxilla is regarded as one of the less stable long-term orthognathic surgical procedures. To increase postoperative stability with direct bone contact, the conventional Le Fort I osteotomy was modified with an inclined osteotomy at the lateral nasal cavity wall. The aim of this study was to evaluate the postoperative stability of the new method for Le Fort I inclined osteotomy for downward maxillary movement. The study included 27 patients with anterior vertical deficiency of the maxilla who underwent Le Fort I inclined osteotomy for downward maxillary movement. Patients were classified into two groups according to the amount of downward movement. The amounts of relapse (cephalometric changes) of the two groups were compared and statistically analyzed. The mean amount of relapse was about 1 mm. The tendency of relapse was not increased by a large initial downward movement with Le Fort I inclined osteotomy. Le Fort I inclined osteotomy was used safely for downward movement in order to increase bone height at the piriform aperture area and resulted in direct bone contact, suggesting it is a useful technique for maintaining postoperative stability. A further study with a larger number of patients is necessary.

  12. Dimensions of Velopharyngeal Space following Maxillary Advancement with Le Fort I Osteotomy Compared to Zisser Segmental Osteotomy: A Cephalometric Study

    PubMed Central

    Karabekmez, Furkan Erol; Kleinheinz, Johannes; Jung, Susanne

    2015-01-01

    The objectives of this study are to assess the velopharyngeal dimensions using cephalometric variables of the nasopharynx and oropharynx as well as to compare the Le Fort I osteotomy technique to Zisser's anterior maxillary osteotomy technique based on patients' outcomes within early and late postoperative follow-ups. 15 patients with severe maxillary deficiency treated with Le Fort I osteotomy and maxillary segmental osteotomy were assessed. Preoperative, early postoperative, and late postoperative follow-up lateral cephalograms, patient histories, and operative reports are reviewed with a focus on defined cephalometric landmarks for assessing velopharyngeal space dimension and maxillary movement (measured for three different tracing points). A significant change was found between preoperative and postoperative lateral cephalometric measurements regarding the distance between the posterior nasal spine and the posterior pharyngeal wall in Le Fort I osteotomy cases. However, no significant difference was found between preoperative and postoperative measurements in maxillary segmental osteotomy cases regarding the same measurements. The velopharyngeal area calculated for the Le Fort I osteotomy group showed a significant difference between the preoperative and postoperative measurements. Le Fort I osteotomy for advancement of upper jaw increases velopharyngeal space. On the other hand, Zisser's anterior maxillary segmental osteotomy does not alter the dimension of the velopharyngeal space significantly. PMID:26273615

  13. Le syndrome de Vogt-Koyanagi Harada dans sa forme purement oculaire: à propos d'un cas

    PubMed Central

    Louaya, Shamil; Bennouk, Youssef; Kriet, Mohamed; Oubaaz, Abdelbarre

    2014-01-01

    Le syndrome de Vogt-Koyanagi-Harada (VKH) est une affection systémique rare, sévère mettant en jeu le pronostic visuel malgré les traitements agressifs, caractérisée par l'association de plusieurs symptômes: oculaires, méningés, auditifs et cutanés secondaire à une auto-immunisation où le mélanocyte serait la cellule cible. Nous rapportons un nouveau cas rare où l'atteinte oculaire est isolée. La sévérité de l'uvéite réside dans la fréquence des récidives, dans la cortico-résistance et dans la forte incidence des complications qui conditionnent le pronostic et expliquent les acuités visuelles finales médiocres. La prise en charge doit être précoce afin d'essayer d'améliorer le pronostic visuel. PMID:25667692

  14. Application of a flush airdata sensing system to a wing leading edge (LE-FADS)

    NASA Technical Reports Server (NTRS)

    Whitmore, Stephen A.; Moes, Timothy R.; Czerniejewski, Mark W.; Nichols, Douglas A.

    1993-01-01

    The feasibility of locating a flush airdata sensing (FADS) system on a wing leading edge where the operation of the avionics or fire control radar system will not be hindered is investigated. The leading-edge FADS system (LE-FADS) was installed on an unswept symmetrical airfoil and a series of low-speed wind-tunnel tests were conducted to evaluate the performance of the system. As a result of the tests it is concluded that the aerodynamic models formulated for use on aircraft nosetips are directly applicable to wing leading edges and that the calibration process is similar. Furthermore, the agreement between the airdata calculations for angle of attack and total pressure from the LE-FADS and known wind-tunnel values suggest that wing-based flush airdata systems can be calibrated to a high degree of accuracy. Static wind-tunnel tests for angles of attack from -50 deg to 50 deg and dynamic pressures from 3.6 to 11.4 lb/sq ft were performed.

  15. Toward a midisuperspace quantization of LeMaitre-Tolman-Bondi collapse models

    SciTech Connect

    Vaz, Cenalo; Witten, Louis; Singh, T. P.

    2001-05-15

    LeMaitre-Tolman-Bondi models of spherical dust collapse have been used and continue to be used extensively to study various stellar collapse scenarios. It is by now well known that these models lead to the formation of black holes and naked singularities from regular initial data. The final outcome of the collapse, particularly in the event of naked singularity formation, depends very heavily on quantum effects during the final stages. These quantum effects cannot generally be treated semiclassically as quantum fluctuations of the gravitational field are expected to dominate before the final state is reached. We present a canonical reduction of LeMaitre-Tolman-Bondi space-times describing the marginally bound collapse of inhomogeneous dust, in which the physical radius R, the proper time of the collapsing dust {tau}, and the mass function F are the canonical coordinates R(r), {tau}(r) and F(r) on the phase space. Dirac's constraint quantization leads to a simple functional (Wheeler-DeWitt) equation. The equation is solved and the solution can be employed to study some of the effects of quantum gravity during gravitational collapse with different initial conditions.

  16. Assessment of nasal septum after Le Fort I osteotomy with computer tomography.

    PubMed

    Moroi, Akinori; Yoshizawa, Kunio; Tsutsui, Takamitsu; Saida, Yuriko; Hotta, Asami; Fukaya, Kenichi; Hiraide, Ryota; Takayama, Akihiro; Tunoda, Tatsuya; Saito, Yuuki; Ueki, Koichiro

    2016-09-01

    The purpose of this study was to evaluate the effects of Le Fort I osteotomy on nasal septum deviation and differences in left and right airway sizes, and to determine whether the nasal septum was affected by differences in the direction of movement. Forty patients underwent conventional Le Fort I osteotomy, and computed tomography (CT) was performed preoperatively, and 1 week and 1 year postoperatively. The nasal septum angle and airway area were measured at the anterior, middle, and posterior positions on the CT images Patients were divided into 2 groups depending on each difference in movement (impaction ≥5 mm or other; anterior movement or other; and impaction asymmetry or other). There were no significant differences in the nasal septum angle and the airway of all patients. Among the patient groups, there were no significant differences in the nasal septum angle and airway. We concluded that conventional LI osteotomy did not influence the nasal septum deviation or the left and right airway asymmetry. Differences in the method of moving the maxilla have not been shown to affect changes in the nasal septum.

  17. A comparative assessment of maxillary perfusion between two different Le Fort I osteotomy techniques.

    PubMed

    Sakharia, A; Muthusekar, M R

    2015-03-01

    Compromised maxillary perfusion following Le Fort I osteotomy is a potentially serious complication resulting in hard and/or soft tissue loss. The aim of this study was to compare the change in perfusion between two techniques of posterior maxillary disjunction by intraoperative measurement of maxillary gingival blood flow (GBF). Further, we sought to correlate the association of the movement of the maxilla and estimated blood loss as factors. The study population comprised 38 individuals, divided equally into two groups: a pterygoid disjunction group and a third molar socket disjunction group. GBF was measured using Doppler flowmetry. A P-value of <0.05 was considered significant. There was a significant drop in GBF in both groups. However, there was no significant difference between the groups based on magnitude of blood flow drop. Superior repositioning of the osteotomized maxilla caused the greatest drop in GBF, which was statistically significant. There was significantly less blood loss in the pterygoid disjunction group. In conclusion, Le Fort I osteotomy causes a significant decrease in GBF. The technique used for posterior maxillary disjunction does not influence the magnitude of drop in perfusion. There is a significant correlation of other factors such as the effect of superior repositioning of the maxilla and blood loss with the osteotomy techniques.

  18. Scale insect larvae preserved in vertebrate coprolites (Le Quesnoy, France, Lower Eocene): paleoecological insights

    NASA Astrophysics Data System (ADS)

    Robin, Ninon; Foldi, Imre; Godinot, Marc; Petit, Gilles

    2016-10-01

    Coprolites of terrestrial vertebrates from the Sparnacian Le Quesnoy locality (Ypresian, Eocene, MP7, 53 Ma; Oise, France) were examined for possible parasitic helminth eggs. The extraction of the coprolite components was performed by a weak acetolyse and a slide mounting in glycerin. This long examination did not reveal paleoparasite remains, which may be explained through several arguments. However, some pollen grains, some enigmatic components, and two well-preserved first-instar cochineal nymphs (Hemiptera: Sternorrhyncha: Coccoidea) were evidenced in coprolites. Identified as Coccidae, these larvae are the earliest stage of the scale insect development ever reported as fossil, revealing the specific environment of preservation that fossilized scats may provide. These observations, combined to the coprolites morphotype, enable to ascribe the fossil scats producer to a small herbivorous mammal present in the deposit (early perissodactyls or Plesiadapidae). Regarding the ecology of extant representatives of Coccidae, this mammal was a likely foliage consumer, and the abundant Juglandaceae and/or Tiliaceae from Le Quesnoy might have lived parasitized by scale insects. These Early Eocene parasites had an already well-established dissemination strategy, with prevalent minute first-instar larvae. The herein performed extraction technique appears well-suited for the study of carbonate coprolites and could certainly be useful for evidencing other kind of microorganisms (including internal parasites).

  19. Etude des interdiffusions en phase solide dans le contact Ni/AlAs

    NASA Astrophysics Data System (ADS)

    Députier, S.; Guivarc'h, A.; Caulet, J.; Poudoulec, A.; Guenais, B.; Minier, M.; Guérin, R.

    1995-04-01

    éposée dans des conditions d'ultra-vide et des couches épaisses d'AlAs épitaxiées sur des substrats de GaAs orientés (001) et (111) ont été étudiées après des traitements thermiques d'une heure, sous balayage de gaz neutres, entre 200 et 600 ^{circ}C. L'utilisation de techniques complémentaires d'analyse (RBS, diffraction X, MET) a permis de mettre en évidence, en fonction de la température de recuit, plusieurs étapes successives d'interaction. Ces étapes correspondent soit à des phases ternaires, mises en évidence lors de la détermination expérimentale du diagramme Ni-Al-As et notées A, B, D par analogie avec celles du diagramme Ni-Ga-As, soit à des mélanges de phases constituées de binaires et/ou de ternaires, toutes ces phases étant plus ou moins fortement texturées sur le substrat. En fait, la nature des phases en présence dépend de l'orientation du substrat, la cinétique de réaction apparaissant plus lente pour l'interaction Ni/AlAs(111) que pour celle Ni/AlAs(001), les étapes successives sont observées : tout d'abord un mélange constitué de la phase ternaire B + NiAl puis un autre mélange : phase ternaire A + NiAl + NiAs et en fin d'interaction les deux binaires : NiAl + NiAs. Sur AlAs(111), seules deux étapes sont mises en évidence, la première correspond à la phase ternaire D, la seconde, en fin d'interaction, est constituée du mélange : phase B + NiAl + NiAs. On remarque dans ce cas le recuit à 600 ^{circ}C n'est pas suffisant pour atteindre le mélange des binaires NiAl et NiAs qui, selon le diagramme ternaire, est le stade ultime de l'interaction Ni/AlAs. L'analyse comparée des interdiffusions Ni/AlAs et Ni/GaAs montre que NiAl est le composé “clé” autour duquel pivote l'interaction Ni/AlAs alors que ce rôle était joué par NiAs lors des interdiffusions Ni/GaAs. Thermiquement stable et fortement texturé sur AlAs, le binaire NiAl apparaît comme un candidat prometteur pour la réalisation d'hétérostructures NiAl/AlAs/GaAs.

  20. Le carcinome verruqueux de la vulve: à propos de quatre cas

    PubMed Central

    Boujoual, Majdouline; Hachi, Hafid; Rimani, Mouna; El Khannoussi, Basma; Bougtab, Abdesslam

    2014-01-01

    Le cancer verruqueux de la vulve est une variante rare et bien différenciéedu carcinome épidermoïdedont les particularités diagnostiques, thérapeutiques et pronostiques méritent d’être distinguées. Il se caractérise par son importante croissance exophytique sans infiltration de la membrane basale. Son évolution est surtout locale rarement métastatique. Il est l'indication d'un traitement chirurgical exclusif avec exérèse large sans curage ganglionnaire de principe. La radiothérapie n'apporte aucun bénéfice en survie. Le pronostic est relativement bon mais grevé par les récidives locales. Nous rapportons quatre cas de carcinome verruqueux de la vulve colligés au Service de Chirurgieà l'Institut National d'Oncologie Rabat, nous discuterons à travers une revue de littérature, leurs modalités diagnostiques thérapeutiques et évolutives. PMID:25328599

  1. Outcome assessment of 603 cases of concomitant inferior turbinectomy and Le Fort I osteotomy

    PubMed Central

    Movahed, Reza; Morales-Ryan, Carlos; Allen, Will R.; Warren, Scott

    2013-01-01

    This retrospective study assessed the outcome of 603 patients undergoing partial inferior turbinectomies (PIT) in association with Lefort I osteotomy. The study included 1234 patients from a single private practice; these patients had dentofacial deformities and underwent Lefort I osteotomy procedures. For the full patient group, 888 patients (72%) were women; in the turbinectomy group, 403 (67%) were women. The anteroposterior, transverse, and vertical dimensions of the mandible, maxilla, and occlusal plane of each subject were assessed, in addition to cephalometric analysis and determination of the presence or absence of temporomandibular joint disorders. PIT, when indicated, was performed after downfracture of the maxilla, providing access to the turbinates where approximately two thirds of the total turbinate volume was removed and septoplasty was completed if indicated. Hypertrophied turbinates causing significant nasal airway obstruction were present in 603 (49%) of the 1234 patients undergoing Le Fort I osteotomy. The results of this study showed that PIT performed simultaneously with Le Fort I osteotomy is a safe method of managing nasal airway obstruction related to hypertrophied turbinates with minimal complications. PMID:24082413

  2. Le Chatelier's principle in sensation and perception: fractal-like enfolding at different scales.

    PubMed

    Norwich, Kenneth H

    2010-01-01

    Le Chatelier's principle asserts that a disturbance, when applied to a resting system may drive the system away from its equilibrium state, but will invoke a countervailing influence that will counteract the effect of the disturbance. When applied to the field of sensation and perception, a generalized stimulus will displace the system from equilibrium, and a generalized adaptation process will serve as the countervailing influence tending to reduce the impact of the stimulus. The principle applies at all levels, from the behavioral to the neural, the larger enfolding the smaller in fractal-like form. Le Chatelier's principle, so applied, leads to the unification of many concepts in sensory science. Ideas as diverse as sensory adaptation, reflex arcs, and simple deductive logic can be brought under the umbrella of a single orienting principle. Beyond unification, this principle allows us to approach many questions in pathophysiology from a different perspective. For example, we find new direction toward the reduction of phantom-limb pain and possibly of vertigo. PMID:21423359

  3. Performance of a shaft seal system for the LE-7 rocket engine oxidizer turbopump

    NASA Astrophysics Data System (ADS)

    Oike, Mamoru; Nosaka, Masataka; Kikuchi, Masataka; Watanabe, Yoshiaki

    An experimental study on a rotating-shaft seal system for a high-pressure liquid oxygen (LOX) turbopump has been conducted to develop the LE-7 engine for the Japanese H-II launch vehicle. The LOX turbopump rotating-shaft seal system, which prevents LOX (4.9 MPa) and the high-pressure turbine-drive gas (16.6 MPa, 970 K) from mixing during high-speed operations (18,000 to 20,000 rpm), consists of the following seals: an LOX seal comprising a floating-ring and a wear-ring, a turbine gas seal comprising two floating-rings, and a helium purge seal comprising two segmented circumferential seal-rings. This report describes experimental and observational results concerning the rotating-shaft seal system obtained in the LOX turbopump operations and the seal tests. Based on comparisons between the measurements and the analytical results, sealing characteristics of the seal system are discussed. Inspections of the sealing surfaces after the engine firing tests demonstrated that the LOX turbopump rotating-shaft seal system has sufficient durability for use in the LE-7 engine for the H-II launch vehicle.

  4. LeFort I segmented osteotomy experience with piezosurgery in orthognathic surgery

    PubMed Central

    Olate, Sergio; Pozzer, Leandro; Unibazo, Alejandro; Huentequeo-Molina, Claudio; Martinez, Felipe; de Moraes, Márcio

    2014-01-01

    The aim of this work was to present the LeFort I segmented osteotomy in consecutive patients using the piezoelectric system. A descriptive study was designed for patients operated on between November 2012 and January 2014. All the patients presented some type of skeletal anomaly and underwent orthognatic surgery via piezoelectric osteotomies. Each maxillary surgery was developed with that system and those patients who also received osteotomies with a reciprocating saw were excluded. Surgical time and complications were analyzed. 19 patients underwent surgery consecutively with an osteotomy average time of 45 minutes. The patients operated on at the beginning were longer surgeries, whereas the final cases were 40 minutes. No type of laceration of vascular elements or laceration of palatal tissue was observed. The protocol was fully implemented, incorporating all the advantages of piezoelectric systems. It is concluded that the LeFort I segmented osteotomy can be performed with low risk of injuring soft tissues and in a time probably less than 50 minutes for the maxillary osteotomy. PMID:25232392

  5. Un nouveau cristal laser largement accordable le BOYS dopé à l'ytterbium

    NASA Astrophysics Data System (ADS)

    Chénais, S.; Druon, F.; Balembois, F.; Georges, P.; Gaumé, R.; Aka, G.; Viana, B.; Vivien, D.

    2002-06-01

    Nous avons étudié les performances laser en pompage par diode de puissance d'un nouveau cristal : le Sr3Y(BO3)3 (acronyme : BOYS), dopé à l'ytterbium. Son spectre d'émission particulièrement large en fait un matériau particulièrement prometteur pour la réalisation de lasers femtosecondes directement pompés par diode. Ses performances ont été comparées à celles d'un verre phosphate ainsi qu'à celles du cristal d' Yb:GdCOB dans les mêmes conditions. Nous démontrons que, tant du point de vue de l'efficacité laser que de la tenue aux fortes puissances, GdCOB et BOYS sont supérieurs au verre ; le BOYS est de surcroît plus accordable (sur 50 nm), mais son comportement thermique limite a priori son usage à des puissances de pompe modérées.

  6. Chronic invasive fungal sinusitis causing a pathologic Le Fort I fracture in an immunocompetent patient.

    PubMed

    Richter, Amy L; Gallagher, K Kelly

    2016-09-01

    We describe the case of a 77-year-old immunocompetent woman with a history of chronic rhinosinusitis who presented with a pathologic Le Fort I fracture after a forceful sneeze. Imaging revealed diffuse sinus opacification and a Le Fort type I complex fracture involving the maxilla, pterygoid plates, clivus, and right nasal bridge. The patient underwent endoscopic debridement of her sinuses, which revealed mucosal dehiscence and otherwise normal healthy bleeding tissue. Anatomic pathology identified necrotic bone with invasive fungal hyphae. Cultures demonstrated Burkholderia cepacia, diphtheroid organisms, and Enterococcus and Serratia spp. The patient was administered an intravenous antibiotic and antifungal for several months, but interval imaging found no significant improvement in bone healing although the stability of her palate had improved on clinical examination. Chronic rhinosinusitis has been found to be a complication of soft-tissue, orbital, and intracranial infections but, to the best of our knowledge, a pathologic facial fracture secondary to chronic invasive fungal and bacterial rhinosinusitis has not been previously reported in the literature. PMID:27657320

  7. Vital staining of palatal soft tissue in horseshoe Le Fort I osteotomy for superior repositioning of the maxilla.

    PubMed

    Omura, Susumu; Iwai, Toshinori; Honda, Koji; Shibutani, Naoki; Fujita, Koichi; Yamashita, Yosuke; Takasu, Hikaru; Murata, Shogo; Tohnai, Iwai

    2015-05-01

    In maxillary orthognathic surgery, superior repositioning of the maxilla is sometimes difficult, and removal of the bony interference, especially around the descending palatine artery, is very time-consuming in cases of severe maxillary impaction. A useful method introduced for superior repositioning of the maxilla is horseshoe-shaped osteotomy combined with Le Fort I osteotomy (horseshoe Le Fort I osteotomy). However, injury to the palatal soft tissue during horseshoe-shaped osteotomy may cause aseptic complications of the maxilla. Therefore, a safe method is required to prevent such injury to reduce the risk for aseptic necrosis. We describe here vital staining of palatal soft tissue in horseshoe Le Fort I osteotomy for safer superior repositioning of the maxilla.

  8. L'engelure causée par le butane commercial au cours d’un accident industriel

    PubMed Central

    Assi-Dje Bi Dje, V.; Abhe, C.M.; Sie-Essoh, J.B.; Kouamé, K.; Vilasco, B.

    2014-01-01

    Summary Les engelures sont encore exceptionnelles en Afrique sub-saharienne, mais l’essor des industries pétrochimiques en rapport avec la promotion d’une large utilisation du gaz domestique (butane commercial) expose au risque de survenue de ce type de brûlures abusivement dites gelures. Nous rapportons un cas de brûlures au froid par gaz de pétrole liquéfié (GPL) en milieu professionnel dont le diagnostic de gravité et la prise en charge tardifs ont défavorisé l’évolution locale. Le respect des mesures de sécurité au sein des usines reste néanmoins le principal moyen de prévention de ce type de brûlures méconnues. PMID:26170791

  9. Update on Development of the Potassium-Argon Laser Experiment (KArLE) Instrument for In Situ Geochronology

    NASA Technical Reports Server (NTRS)

    Cohen, Barbara A.; Li, Z.-H.; Miller, J. S.; Brinckerhoff, W. B.; Clegg, S. M.; Mahaffy, P. R.; Swindle, T. D.; Wiens, R. C.

    2013-01-01

    Absolute dating of planetary samples is an essential tool to establish the chronology of geological events, including crystallization history, magmatic evolution, and alteration. We are addressing this challenge by developing the Potassium (K) -- Argon Laser Experiment (KArLE), building on previous work to develop a K-Ar in situ instrument. KArLE ablates a rock sample, determines the K in the plasma state using laser-induced breakdown spectroscopy (LIBS), measures the liberated Ar using quadrupole mass spectrometry (QMS), and relates the two by the volume of the ablated pit using laser confocal microscopy (LCM). Our goal is for the KArLE instrument to be capable of determining the age of several kinds of planetary samples to address a wide range of geochronolgy problems in planetary science.

  10. Traitement séquentiel de la lithiase biliaire versus chirurgie seule: analyse par le score de propension

    PubMed Central

    Toughrai, Imane; Ahid, Samir; Laalim, Said Ait; Majdoub, Karim Ibn; Mazaz, Khalid; Taleb, Khalid Ait

    2013-01-01

    Introduction L'objectif étant de comparer, rétrospectivement, les résultats du traitement combiné séquentiel à ceux de la chirurgie ouverte chez des patients pris en charge pour lithiase vésiculaire (LV) et lithiase de la voie biliaire principale (LVBP) durant la même hospitalisation Méthodes L’étude a concerné 132 patients pris en charge au CHU Hassan de Fès entre Décembre 2003 et Décembre 2011. Nos patients ont été répartis sur deux groupes thérapeutiques. Le premier correspondant aux malades ayant eu une sphincterotomie endoscopique première suivie d'une cholécystectomie par voie cœlioscopique. Le deuxième incluant les malades ayant eu un traitement exclusivement chirurgical. La comparaison des deux groupes a porté sur les résultats en termes de morbi-mortalité, de séjour post opératoire et d'efficacité du traitement. Résultats L'appariement des deux groupes thérapeutiques a permis de retenir 64 patients. L’âge moyen a été de 54 ans ± 14 avec un sexe ratio F/H de 2. Quatorze pourcents de nos malades avaient des tares associées. L'ictère ± angiocholite a été noté chez 76,6% de nos patients. Des anomalies du bilan hépatique ont été relevées chez plus de 70% des malades. L’échographie abdominale et le scanner ont été réalisés chez 97% et 30% des malades respectivement. La médiane du séjour post opératoire a été de 2,5 jours pour le premier groupe versus 5 jours pour le deuxième. Nous avons eu un cas de décès post opératoire dans le premier groupe. Les complications post opératoires ont été à type d'un cas de fistule biliaire et 2 cas de sepsis dans le premier groupe. Deux cas de lithiase résiduelle ont été observés dans le groupe de chirurgie seule. Conclusion Le choix d'une stratégie de prise en charge de la lithiase biliaire devra prendre en considération le plateau technique disponible et le degré d'expertise des opérateurs. Dans l'attente d'une maîtrise parfaite du traitement de la

  11. Le Pseudomonas: Experience du Centre des Brules D’Annaba et Revue de la Litterature

    PubMed Central

    Chaibdraa, A.; Medjellekh, M.S.; Saouli, A.; Bentakouk, M.C.

    2008-01-01

    Summary Le Pseudomonasest un agent pathogène à l'origine d'infections nosocomiales graves dans les centres des brûlés. Son opportunisme et sa virulence en font une préoccupation majeure. Ce travail se propose d'évaluer la place de cette bactérie dans l'écologie bactérienne locale et d'en apprécier la sensibilité aux antibiotiques. Cette étude rétrospective préliminaire porte sur la période de juin 2003 à décembre 2005. Elle intéresse l'ensemble des prélèvements bactériologiques ayant pu être réalisés au centre des brûlés d'Annaba. L'effectif est de 633 micro-organismes isolés dont 128 Pseudomonas (20,2%): 127 aeruginosa (99,2%), 1 fluorescens (0,8%); distribution selon le site de prélèvement: écouvillon (87,5%), prélèvement trachéobronchique (4,6%), hémoculture (3,1%), cathéters (1,6%), urine (1,6%) et sonde urinaire (1,6%). Le pyocyanique se situe après le staphylocoque pour les prélèvements précoces et repasse en tête après un séjour supérieur à une semaine, où 89% des pyocyaniques sont identifiés. Il est en première position dans les pneumopathies sous ventilation assistée invasive. Il se classe troisième dans les hémocultures et les cultures de cathéters. Dans les infections urinaires il est devancé par Candida et la flore périnéale. Les 128 antibiogrammes regroupent 314 réponses sensibles. La sensibilité à plus de deux antibiotiques est de 68%, à deux antibiotiques 24% et à un antibiotique 8%. Seules quatre molécules restent actives: ciprofloxacine > péfloxacine > pipéracilline > ceftazidime. Une résistance absolue est retrouvée pour trois Pseudomonas (2,4%). Le pronostic sévère des infections nosocomiales à pyocyanique et les risques d'options thérapeutiques très limitées font toute leur gravité, d'où l'intérêt de respecter des règles strictes de prescription des antibiotiques et des mesures de prévention. PMID:21991140

  12. Place de la bili-IRM dans le diagnostic etiologique des icteres cholestatiques à Dakar

    PubMed Central

    Badji, Nfally; Akpo, Geraud; Deme, Hamidou; Toure, Mouhamadou Hamine; Ly, Mamadou; Ndong, Boucar; Niang, El Hadji

    2016-01-01

    La Bili-IRM est une méthode diagnostique d’introduction relativement récente dans l’arsenal d’exploration de la pathologie bilio-pancréatique. Il s’agit d’une technique fiable reproductible et non invasive, permettant la visualisation directe des voies biliaires et pancréatiques. Le but de ce travail était d’étudier les aspects morphologiques des principales anomalies et d’évaluer la place de la bili-IRM dans le diagnostic étiologique des ictères cholestatiques. Il s’agit d’une étude rétrospective réalisée sur 4 ans et six mois (Janvier 2008 à Juillet 2012) portant sur 17 patients colligés dans les services d’imagerie médicale du CHUN de Fann et de l’hôpital Principal de Dakar. Tous les patients ont bénéficié d’une IRM (1,5T) avec des protocoles adaptés en fonction de la pathologie explorée. Les dossiers retenus sont ceux dont le diagnostic a été établi à partir du bilan biologique et ayant bénéficié à la fois d’une bili-IRM et d’une exploration chirurgicale. Il s’agissait de 05 femmes et de 12 hommes soit un sexe ratio de 2.4. L’âge moyen des patients était de 58 ans avec des extrêmes de 35 et 81 ans. Les tumeurs de Klatskin étaient observées chez 07 patients avec une forme infiltrante dans 71% des cas et une forme exophytique dans 28% des cas. Les cancers de la vésicule biliaire étaient notés dans 28% des cas. Les cancers de la tête du pancréas représentaient 28% des cas. La lithiase de la voie biliaire principale était présente chez 05 patients avec un empierrement cholédocien dans 60% des cas et une lithiase unique dans 40% des cas. Toutes ces lésions étaient responsables d’une dilatation des VBIH. Un cas de dilatation des voies biliaires intra et extra hépatiques était retrouvé sans cause bilio-pancréatique. La bili-IRM est l’examen de choix dans l’exploration des ictères cholestatiques. Elle doit être demandée en première intention lorsqu’on suspecte une lithiase r

  13. Development of mask-DFM system MiLE load estimation of mask manufacturing

    NASA Astrophysics Data System (ADS)

    Nagamura, Yoshikazu; Hosono, Kunihiro; Narukawa, Shogo; Mohri, Hiroshi; Hayashi, Naoya; Kato, Masahiro; Kawase, Hidemichi

    2007-10-01

    Load of photomask manufacturing for the most advanced semiconductor devices is increasing due to the complexity of mask layouts caused by highly accurate RET or OPC, tight specification for 2D/3D mask structures, and requirements of quick deliveries. The mask cost becomes a concern of mask users especially in SoC businesses because the number of masks required throughout the wafer process is almost the same for each product regardless of the variety in production volume when a unified platform is applied to the designs. Shares of mask cost within total production cost cannot be ignored especially in small volume SoC products. DFM (design for manufacturing) is inevitable in a mask level as well as in a wafer level to solve the cost problem. "Mask-DFM" is a method to decrease the burden of mask manufacturing and to improve the yield and quality of masks, not only by modification of mask pattern layouts (design) but also all other things including utilization of designer's intents. We have developed our Mask-DFM system called "MiLE", that calculates mask-manufacturing workload through layout analyses combining information of mask configuration, and visualizes the consequence of Mask-DFM efforts. "MiLE (Mask manufacturIng Load Estimation)" calculates a relative index which represents the mask manufacturing workload determined by factors of 1) EB writing, 2) defect inspection/repair, 3) materials and processes and 4) specification. All the factors are computed before tape-outs for mask making in the system by the following methods. To estimate EB writing time, we applied high-throughput simulator and counted the number of "shot", minimum figure unit in EB writing, by using post-OPC layout data. Mask layout that caused troubles and extra load in mask inspection or repair was specified from MRC (mask rule checking) of the same post-OPC data. Additional layout analysis perceives designer's intents that are described in the layout data and these are reflected in the

  14. LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants

    PubMed Central

    2014-01-01

    Background Arabidopsis ZBF1/MYC2bHLH transcription factor is a repressor of photomorphogenesis, and acts as a point of cross talk in light, abscisic acid (ABA) and jasmonic acid (JA) signaling pathways. MYC2 also functions as a positive regulator of lateral root development and flowering time under long day conditions. However, the function of MYC2 in growth and development remains unknown in crop plants. Results Here, we report the functional analyses of LeMYC2 in tomato (Lycopersicon esculentum). The amino acid sequence of LeMYC2 showed extensive homology with Arabidopsis MYC2, containing the conserved bHLH domain. To study the function of LeMYC2 in tomato, overexpression and RNA interference (RNAi) LeMYC2 tomato transgenic plants were generated. Examination of seedling morphology, physiological responses and light regulated gene expression has revealed that LeMYC2 works as a negative regulator of blue light mediated photomorphogenesis. Furthermore, LeMYC2 specifically binds to the G-box of LeRBCS-3A promoter. Overexpression of LeMYC2 has led to increased root length with more number of lateral roots. The tomato plants overexpressing LeMYC2 have reduced internode distance with more branches, and display the opposite morphology to RNAi transgenic lines. Furthermore, this study shows that LeMYC2 promotes ABA and JA responsiveness. Conclusions Collectively, this study highlights that working in light, ABA and JA signaling pathways LeMYC2 works as an important regulator for growth and development in tomato plants. PMID:24483714

  15. The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data

    PubMed Central

    Eichler, Gabriel S; Reimers, Mark; Kane, David; Weinstein, John N

    2007-01-01

    Interpretation of microarray data remains a challenge, and most methods fail to consider the complex, nonlinear regulation of gene expression. To address that limitation, we introduce Learner of Functional Enrichment (LeFE), a statistical/machine learning algorithm based on Random Forest, and demonstrate it on several diverse datasets: smoker/never smoker, breast cancer classification, and cancer drug sensitivity. We also compare it with previously published algorithms, including Gene Set Enrichment Analysis. LeFE regularly identifies statistically significant functional themes consistent with known biology. PMID:17845722

  16. Deep Venous Thrombosis in Teen With Crouzon Syndrome Post-Le Fort III Osteotomy With Rigid External Distraction.

    PubMed

    Roussel, Lauren O; Myers, Rene P; Girotto, John A

    2015-11-01

    Venous thromboembolic events are rare in pediatric patients. Risk factors associated with the development of venous thromboembolic events in pediatric patients include the use of central venous catheters, hospitalization, cancer, sepsis, trauma, surgery, and congenital prothrombotic disorders.The authors present the case of a 14-year-old man with Crouzon syndrome who required Le Fort III osteotomy with rigid external distraction for significant midface hypoplasia who presented postoperatively with an extensive deep venous thrombosis. This is the first reported case of symptomatic venous thrombosis post-Le Fort III osteotomy and rigid external distraction. Although rare, surgeons should be aware of this potential complication.

  17. Volume Measurements of Laser-generated Pits for in Situ Geochronology Using KArLE (Potassium-Argon Laser Experiment)

    NASA Technical Reports Server (NTRS)

    French, R. A.; Cohen, B. A.; Miller, J. S.

    2014-01-01

    KArLE (Potassium-­-Argon Laser Experiment) has been developed for in situ planetary geochronology using the K - Ar (potassium-­-argon) isotope system, where material ablated by LIBS (Laser-­-Induced Breakdown Spectroscopy) is used to calculate isotope abundances. We are determining the accuracy and precision of volume measurements of these pits using stereo and laser microscope data to better understand the ablation process for isotope abundance calculations. If a characteristic volume can be determined with sufficient accuracy and precision for specific rock types, KArLE will prove to be a useful instrument for future planetary rover missions.

  18. A Rare Orbital Complication of Eye Exodeviation With Limited Abduction During Monobloc Le Fort III Distraction Osteogenesis.

    PubMed

    Hariri, Firdaus; Cheung, Lim Kwong; Rahman, Zainal Ariff Bin Abdul; Ramasamy, Sundrarajan Naidu; Ganesan, Dharmendra

    2015-07-01

    Monobloc Le Fort III distraction osteogenesis allows superior skeletal advancement in treating severe syndromic craniosynostosis. We report a rare orbital complication in a 3-year-old boy with Crouzon syndrome who developed right-eye exodeviation with limited abduction during the intradistraction period following this surgery. Images from a computed tomography scan confirmed direct impingement of the distracted right lateral orbital wall to the lateral rectus muscle. The impingement was surgically relieved via lateral orbital wall osteotomy. Ten months postdistraction, a review showed normal eye movement. A lateral orbital osteotomy cut for a monobloc Le Fort III distraction should be designed near the rim to prevent this complication. PMID:25007030

  19. Deep Venous Thrombosis in Teen With Crouzon Syndrome Post-Le Fort III Osteotomy With Rigid External Distraction.

    PubMed

    Roussel, Lauren O; Myers, Rene P; Girotto, John A

    2015-11-01

    Venous thromboembolic events are rare in pediatric patients. Risk factors associated with the development of venous thromboembolic events in pediatric patients include the use of central venous catheters, hospitalization, cancer, sepsis, trauma, surgery, and congenital prothrombotic disorders.The authors present the case of a 14-year-old man with Crouzon syndrome who required Le Fort III osteotomy with rigid external distraction for significant midface hypoplasia who presented postoperatively with an extensive deep venous thrombosis. This is the first reported case of symptomatic venous thrombosis post-Le Fort III osteotomy and rigid external distraction. Although rare, surgeons should be aware of this potential complication. PMID:26595005

  20. Dermatomyosite du sujet âgé: étude de 4 observations dans le sud tunisien

    PubMed Central

    Frikha, Faten; Snoussi, Mouna; Salah, Raida Ben; Saidi, Noura; Kaddour, Neila; Bahloul, Zouhir

    2012-01-01

    La dermatomyosite (DM) touche essentiellement l’adolescent et l’adulte jeune, elle est très rare chez le sujet âgé, le plus souvent associée à des complications iatrogènes et à une pathologie cancéreuse. Nous avons étudié les caractéristiques de la DM du sujet âgé à travers une étude rétrospective dans laquelle nous avons comparé 4 patients âgés de plus de 65 ans au début de la myosite avec 40 sujets jeunes. PMID:23308331

  1. Analyse de L'ancrage des Vortex Intergrains pour le Yttrium BARYUM(2) CUIVRE(3) OXYGENE(7) Polycristallin

    NASA Astrophysics Data System (ADS)

    Fournier, Patrick

    Le Modele de l'Etat Critique Generalise (MECG) est utilise pour decrire les proprietes magnetiques et de transport du YBa_2Cu_3O _7 polycristallin. Ce modele empirique permet de relier la densite de courant critique a la densite de lignes de flux penetrant dans la region intergrain. Deux techniques de mesures sont utilisees pour caracteriser nos materiaux. La premiere consiste a mesurer le champ au centre d'un cylindre creux en fonction du champ magnetique applique pour des temperatures comprises entre 20 et 85K. En variant l'epaisseur de la paroi du cylindre creux, il est possible de suivre l'evolution des cycles d'hysteresis et de determiner des champs caracteristiques qui varient en fonction de cette dimension. En utilisant un lissage des resultats experimentaux, nous determinons J _{co}, H_ {o} et n, les parametres du MECG. La forme des cylindres, avec une longueur comparable au diametre externe, entrai ne la presence d'un champ demagnetisant qui peut etre inclus dans le modele theorique. Ceci nous permet d'evaluer la fraction du volume ecrante, f _{g}, ainsi que le facteur demagnetisant N. Nous trouvons que J_{ co}, H_{o} et f_{g} dependent de la temperature, tandis que n et N (pour une epaisseur de paroi fixe) n'en dependent pas. La deuxieme technique consiste a mesurer le courant critique de lames minces en fonction du champ applique pour differentes temperatures. Nous utilisons un montage que nous avons developpe permettant d'effectuer ces mesures en contact direct avec le liquide refrigerant, i.e. dans l'azote liquide. Nous varions la temperature du liquide en variant la pression du gaz au-dessus du bain d'azote. Cette methode nous permet de balayer des temperatures entre 65K et la temperature critique du materiau ({~ }92K). Nous effectuons le lissage des courbes de courant critique en fonction du champ applique encore a l'aide du MECG, pour a nouveau obtenir ses parametres. Pour trois echantillons avec des traitements thermiques differents, les parametres

  2. Water-resources reconnaissance of Île de la Gonâve, Haiti

    NASA Astrophysics Data System (ADS)

    Troester, Joseph W.; Turvey, Michael D.

    Île de la Gonâve is a 750-km2 island off the coast of Haiti. The depth to the water table ranges from less than 30 m in the Eocene and Upper Miocene limestones to over 60 m in the 300-m-thick Quaternary limestone. Annual precipitation ranges from 800-1,400 mm. Most precipitation is lost through evapotranspiration and there is virtually no surface water. Roughly estimated from chloride mass balance, about 4% of the precipitation recharges the karst aquifer. Cave pools and springs are a common source for water. Hand-dug wells provide water in coastal areas. Few productive wells have been drilled deeper than 60 m. Reconnaissance field analyses indicate that groundwater in the interior is a calcium-bicarbonate type, whereas water at the coast is a sodium-chloride type that exceeds World Health Organization recommended values for sodium and chloride. Tests for the presence of hydrogen sulfide-producing bacteria were negative in most drilled wells, but positive in cave pools, hand-dug wells, and most springs, indicating bacterial contamination of most water sources. Because of the difficulties in obtaining freshwater, the 110,000 inhabitants use an average of only 7 L per person per day. L'Île de la Gonâve est une île de 750 km2 au large de la côte d'Haïti. La profondeur de la nappe varie entre moins de 30 m dans les calcaires de l'Éocène et du Miocène supérieur à plus de 60 m dans les calcaires quaternaires épais de 300 m. Les précipitations annuelles sont comprises entre 800-1.400 mm. La plus grande partie des précipitations est perdue par évapotranspiration et il n'y a pratiquement pas d'eau de surface. Le bilan de masse des chlorures permet d'estimer à 4% des précipitations le montant de la recharge de l'aquifère karstique. Des bassins dans les grottes et des sources sont la source d'eau courante. Des puits creusés à la main fournissent de l'eau dans les zones côtières. Quelques puits productifs ont été forés dépassant 60 m de profondeur. L

  3. Water-resources reconnaissance of Île de la Gonâve, Haiti

    NASA Astrophysics Data System (ADS)

    Troester, Joseph W.; Turvey, Michael D.

    Île de la Gonâve is a 750-km2 island off the coast of Haiti. The depth to the water table ranges from less than 30 m in the Eocene and Upper Miocene limestones to over 60 m in the 300-m-thick Quaternary limestone. Annual precipitation ranges from 800-1,400 mm. Most precipitation is lost through evapotranspiration and there is virtually no surface water. Roughly estimated from chloride mass balance, about 4% of the precipitation recharges the karst aquifer. Cave pools and springs are a common source for water. Hand-dug wells provide water in coastal areas. Few productive wells have been drilled deeper than 60 m. Reconnaissance field analyses indicate that groundwater in the interior is a calcium-bicarbonate type, whereas water at the coast is a sodium-chloride type that exceeds World Health Organization recommended values for sodium and chloride. Tests for the presence of hydrogen sulfide-producing bacteria were negative in most drilled wells, but positive in cave pools, hand-dug wells, and most springs, indicating bacterial contamination of most water sources. Because of the difficulties in obtaining freshwater, the 110,000 inhabitants use an average of only 7 L per person per day. L'Île de la Gonâve est une île de 750 km2 au large de la côte d'Haïti. La profondeur de la nappe varie entre moins de 30 m dans les calcaires de l'Éocène et du Miocène supérieur à plus de 60 m dans les calcaires quaternaires épais de 300 m. Les précipitations annuelles sont comprises entre 800-1.400 mm. La plus grande partie des précipitations est perdue par évapotranspiration et il n'y a pratiquement pas d'eau de surface. Le bilan de masse des chlorures permet d'estimer à 4% des précipitations le montant de la recharge de l'aquifère karstique. Des bassins dans les grottes et des sources sont la source d'eau courante. Des puits creusés à la main fournissent de l'eau dans les zones côtières. Quelques puits productifs ont été forés dépassant 60 m de profondeur. L

  4. Modelisation numerique et validation experimentale d'un systeme de protection contre le givre par elements piezoelectriques

    NASA Astrophysics Data System (ADS)

    Harvey, Derek

    Le degivrage au moyen d'actuateurs piezoelectriques est considere comme une avenue prometteuse pour le developpement de systemes a faible consommation d'energie applicables aux helicopteres legers. Ce type de systeme excite des frequences de resonances d'une structure pour produire des deformations suffisantes pour rompre l'adherence de la glace. Par contre, la conception de tel systeme demeure generalement mal comprise. Ce projet de maitrise etudie l'utilisation de methodes numeriques pour assister la conception des systemes de protection contre le givre a base d'elements piezoelectriques. La methodologie retenue pour ce projet a ete de modeliser differentes structures simples et de simuler l'excitation harmonique des frequences de resonance au moyen d'actuateurs piezoelectriques. Le calcul des frequences de resonances ainsi que la simulation de leur excitation a ensuite ete validee a l'aide de montages experimentaux. La procedure a ete realisee pour une poutre en porte-a-faux et pour une plaque plane a l'aide du logiciel de calcul par elements finis, Abaqus. De plus, le modele de la plaque plane a ete utilise afin de realiser une etude parametrique portant sur le positionnement des actuateurs, l'effet de la rigidite ainsi que de l'epaisseur de la plaque. Finalement, la plaque plane a ete degivree en chambre climatique. Des cas de degivrage ont ete simules numeriquement afin d'etudier la possibilite d'utiliser un critere base sur la deformation pour predire le succes du systeme. La validation experimentale a confirme la capacite du logiciel a calculer precisement a la fois les frequences et les modes de resonance d'une structure et a simuler leur excitation par des actuateurs piezoelectriques. L'etude revele que la definition de l'amortissement dans le modele numerique est essentiel pour l'obtention de resultats precis. Les resultats de l'etude parametrique ont demontre l'importance de minimiser l'epaisseur et la rigidite afin de reduire la valeur des frequences

  5. Pour Une Poesie Chretienne a L'age Baroque: Mysticisme, Heroisme et Feminisme Chez Pierre Le Moyne 1602-1671

    ERIC Educational Resources Information Center

    Fares, Laila

    2012-01-01

    The study constituting the object of this research on one of the best French poets of the 17th century, yet one of the least known, Pierre Le Moyne, aims at restoring this great French poet in his right place, preparing and clearing the way in order to allow further research and stimulate future interest in his works. Pierre Le Moyne is not only…

  6. Recommandations pour le dépistage de l’hypertension chez les adultes canadiens

    PubMed Central

    Lindsay, Patrice; Gorber, Sarah Connor; Joffres, Michel; Birtwhistle, Richard; McKay, Donald; Cloutier, Lyne

    2013-01-01

    Résumé Objectif Présenter des recommandations concernant le dépistage de l’hypertension chez les adultes de 18 ans et plus qui n’ont pas reçu antérieurement de diagnostic d’hypertension. Qualité des données Les données probantes sont tirées d’une recension systématique dans MEDLINE, EMBASE et la base de données des synthèses systématiques de la Collaboration Cochrane (EBM Reviews), de janvier 1985 à septembre 2011. Les types d’études retenues se limitaient aux études randomisées contrôlées, aux synthèses systématiques et aux études observationnelles avec groupes témoins. Message principal Trois fortes recommandations se sont dégagées de données probantes de qualité modérée. Il est recommandé de mesurer la pression artérielle à toutes les consultations appropriées en soins primaires, conformément aux techniques actuelles décrites dans les recommandations du Programme éducatif canadien sur l’hypertension pour la mesure de la pression artérielle en cabinet et en soins ambulatoires. Les critères du Programme éducatif canadien sur l’hypertension pour l’évaluation et le diagnostic de l’hypertension devraient s’appliquer aux personnes chez qui on observe une pression artérielle élevée. Conclusion À la suite d’un examen des plus récentes données probantes, le Groupe d’étude canadien sur les soins de santé préventifs continue de recommander la mesure de la pression artérielle lors des consultations périodiques auprès du médecin.

  7. Long-term stability and prediction of soft tissue changes after LeFort I surgery.

    PubMed

    Hack, G A; de Mol van Otterloo, J J; Nanda, R

    1993-12-01

    Many evaluations of soft tissue changes after orthognathic surgery have been undertaken, and many correlations of soft tissue to hard tissue movements have been established. These studies have not, however, specifically discussed the long-term stability or characteristics of the soft tissue changes. The objectives of this study were (1) to determine the long term stability of soft tissue changes 5 years after LeFort I osteotomy, (2) to determine reliable correlations, if any, of soft tissue changes to bony movements effected in surgery, and (3) to determine the predictability of soft tissue changes as an aid to orthodontic treatment planning. Cephalometric data from 25 patients who were treated with LeFort I osteotomy with or without a concurrent mandibular procedure were analyzed retrospectively. Cases were selected from the patient records of the Department of Oral Surgery of the Vrije Universiteit in Amsterdam, the Netherlands. These patients were followed up at four time points, the last being a mean of 6.1 years after surgery. Analysis of stability data revealed that most horizontal and vertical soft tissue change after LeFort I surgery occurred in the first year after surgery. Significant (> 10%) change continued to occur for subnasale, labrale inferius, upper lip protrusion, lower lip protrusion, and soft tissue convexity during the subsequent 5 years. Hard tissue to soft tissue correlations were calculated and ratios of soft tissue to hard tissue movement were determined for appropriate hard and soft tissue landmarks at four time intervals. Reliable correlations of hard tissue change at surgery to 5-year soft tissue change could be made for 10 variables, which was considerably less frequently than for 1-year soft tissue change. The relatively low reliability of long-term prediction correlations suggests that soft tissue movements may be more independent of hard tissue over time. One-year prediction values were similar to 5-year values and thus could be used

  8. Characterization of sediment sources in the Le Sueur River watershed, southern Minnesota

    NASA Astrophysics Data System (ADS)

    Belmont, P.; Perg, L.; Day, S.; Jennings, C.; Gran, K.; Johnson, A.; Wilcock, P.

    2007-12-01

    Low-relief, tectonically quiescent landscapes are fundamentally important for fulfilling economic and societal needs. In historic times humans have, no doubt, greatly enhanced sediment yield from these landscapes to an extent that is comparable to, if not greater than that from many tectonically active areas, yet they have received little attention from the geomorphic community. Currently, our understanding of integrated watershed sediment dynamics in low-relief landscapes is insufficient for proper development of widely-applicable, predictive models of sediment sources, transport and storage. This insufficiency limits our ability to deconvolve anthropogenic versus natural drivers of landscape change and limits our ability to develop reasonable management goals in these economically important landscapes. The Le Sueur River, southern Minnesota, is impaired by sediment under the Clean Water Act and is one of the largest contributors of sediment and colloidal phosphorus to the Minnesota River. The goal of this project is to develop an integrated sediment budget for the Le Sueur watershed that can be used to inform best management practices to achieve the greatest reduction of in-stream turbidity. We are combining field mapping and granulometry with geomorphic modeling, LiDAR technology, and strategic cosmogenic nuclide analysis to determine the proportion of the suspended load that is coming from erosion of uplands, streambanks, bluffs, and ravines, respectively. Preliminary analysis of the relationship between local channel slope and contributing drainage area indicates two distint knickzones migrating up the Le Sueur River system. A graded reach (river km 35-80) is bound on either side by the two knickzones. Our experimental design will test two competing hypotheses. If erosional hotspots are linked to knick migration, we hypothesize that most proximate to the lower extent of the knicks: a) ravines will be steeper and contain convex banks and b) erosion rates from

  9. Integrated Meteorological Observation Network in Castile-León (Spain)

    NASA Astrophysics Data System (ADS)

    Merino, A.; Guerrero-Higueras, A. M.; Ortiz de Galisteo, J. P.; López, L.; García-Ortega, E.; Nafría, D. A.; Sánchez, J. L.

    2012-04-01

    In the region of Castile-Leon, in the northwest of Spain, the study of weather risks is extremely complex because of the topography, the large land area of the region and the variety of climatic features involved. Therefore, as far as the calibration and validation of the necessary tools for the identification and nowcasting of these risks are concerned, one of the most important difficulties is the lack of observed data. The same problem arises, for example, in the analysis of particularly relevant case studies. It was hence deemed necessary to create an INTEGRATED METEOROLOGICAL OBSERVATION NETWORK FOR CASTILE-LEON. The aim of this network is to integrate within one single platform all the ground truth data available. These data enable us to detect a number of weather risks in real time. The various data sources should include the networks from the weather stations run by different public institutions - national and regional ones (AEMET, Junta de Castilla y León, Universities, etc.) -, as well as the stations run by voluntary observers. The platform will contain real or cuasi-real time data from the ground weather stations, but it will also have applications to enable voluntary observers to indicate the presence or absence of certain meteors (snow, hail) or even provide detailed information about them (hailstone size, graupel, etc.). The data managed by this network have a high scientific potential, as they may be used for a number of different purposes: calibration and validation of remote sensing tools, assimilation of observation data from numerical models, study of extreme weather events, etc. An additional aim of the network is the drawing of maps of weather risks in real time. These maps are of great importance for the people involved in risk management in each region, as well as for the general public. Finally, one of the first applications developed has been the creation of observation maps in real time. These applications have been constructed using NCL

  10. Deep inelastic structure functions from electron scattering on hydrogen, deuterium, and iron at 0. 6 GeV sup 2 le Q sup 2 le 30. 0 GeV sup 2

    SciTech Connect

    Whitlow, L.W.

    1990-03-01

    We report the final results from experiment E140, a recent deep inelastic electron-deuterium and electron-iron scattering experiment at SLAC. In addition, we present the results of a combined global analysis of all SLAC deep inelastic electron-hydrogen and electron-deuterium cross section measurements between 1970 and 1983. Data from seven earlier experiments are re-radiatively corrected and normalized to experiment E140. We report extractions of R(x,Q{sup 2}) and F{sub 2}(x,Q{sup 2}) for hydrogen and deuterium over the entire SLAC kinematic range: .06{le} x {le}.90 and 0.6{le} Q{sup 2} {le}30.0 (GeV{sup 2}). We fine that R{sup p} = R{sup d}, as expected by QCD. Extracted values of R(x,Q{sup 2}) are significantly larger than predictions based on QCD and on QCD with the inclusion of kinematic target mass terms. This difference indicates that dynamical higher twist effects may be important in the SLAC kinematic range. A best fit empirical model of R(x,Q{sup 2}) is used to extract F{sub 2} from each cross section measurement. These F{sub 2} extractions are compared with F{sub 2} data from EMC and BCDMS. Agreement is observed with EMC when the EMC data are multiplied by 1.07. Agreement is observed with BCDMS over a limited range in x. The ratios of F{sub 2}{sup d}/F{sub 2}{sup p} are examined for Q{sup 2} dependence. We observe a significant negative slope for x {le} .6, and a significant positive slope above x > .7, in excellent agreement with predictions based on QCD with the inclusion of kinematic target mass terms. 111 refs., 40 figs., 34 tabs.

  11. The Portevin-Le Châtelier Effect in a Metastable Austenitic Stainless Steel

    NASA Astrophysics Data System (ADS)

    Müller, Alexandra; Segel, Christian; Linderov, Mikhail; Vinogradov, Alexei; Weidner, Anja; Biermann, Horst

    2016-01-01

    The Portevin-Le Châtelier (PLC) effect was investigated in a high-alloy metastable CrMnNi cast steel during tensile tests for the range of deformation temperatures between 293 K and 413 K (20 °C and 140 °C) and for nominal strain rates ranging between 10-4 and 10-1 s-1. Analysis of the stress-strain curves was complemented by in situ measurements of thermal and acoustic emissions as well as by digital image correlation, enabling determination of various local characteristics of plastic flow and clarification of individual contributions of different microscopic mechanisms involved in plastic deformation. It was shown that the PLC effect in the investigated CrMnNi steel was caused by the diffusion of interstitial atoms in the bcc phases.

  12. Calcitropic actions of prolactin in freshwater North American eel (Anguilla rostrata LeSueur).

    PubMed

    Flik, G; Fenwick, J C; Wendelaar Bonga, S E

    1989-07-01

    In freshwater-acclimated American eels (Anguilla rostrata LeSueur), ovine prolactin and grafts of the part of the pituitary gland containing the prolactin cells induced hypercalcemia. The hypercalcemia was associated with increased uptake of calcium from the water (resulting from increased influx and decreased efflux) and with enhanced high-affinity Ca2+-adenosinetriphosphatase (ATPase) activity in the gills, the putative biochemical correlate of the branchial Ca2+ pump. Kinetic analyses of ATPase-mediated Ca2+ transport in plasma membrane vesicles of branchial epithelium provided evidence that prolactin enhanced the maximum velocity of the Ca2+ pump. Prolactin treatments raised plasma cortisol levels slightly but significantly in eels. However, cortisol per se was not hypercalcemic in eels and did not stimulate the branchial Ca2+ pump. We conclude that the hypercalcemic potency of prolactin in fish relates to its stimulatory action on active Ca2+ transport in the gills.

  13. Discharge ratings for control gates at Mississippi River Lock and Dam 14, Le Claire, Iowa

    USGS Publications Warehouse

    Heinitz, A.J.

    1985-01-01

    The water level of the navigation pools on the Mississippi River are maintained by the operation of tainter and roller gates at the locks and dams. Discharge ratings for the gates on Lock and Dam 14, at Le Claire, Iowa, were developed from current-meter discharge measurements made in the forebays of the gate structures. Methodology is given to accurately compute the vertical gate openings of the tainter gates. Discharge coefficients, in equations that express discharges as a function of tailwater head, headwater head, and vertical height of gate opening, were determined for conditions of submerged-orifice and free-weir flow. A comparison of the rating discharge to the hydraulic model rating discharges is given for submerged orifice flow for the tainter and roller gates. (Author 's abstract)

  14. Evaluation of an interactive multi-media device for delivering information on Le Fort I osteotomy.

    PubMed

    El Azem, Assem; Benington, Philip C M; Khambay, Balvinder S; Ayoub, Ashraf F

    2014-09-01

    This study was carried out on volunteers to evaluate a newly developed interactive software package aimed at informing prospective Le Fort I osteotomy patients regarding the surgical technique and possible complications. The aim of the study was to compare two methods of information delivery; a multi-media tablet device delivering both graphic and verbal information, and an audio device delivering essentially the same information in verbal form only. The null hypothesis was that there would be no difference between the efficiencies of the two methods. The subjects' ability to recall the information delivered by both devices was assessed using a questionnaire. The tablet device participants scored an average of 15.48 points, while the audio device participants scored an average of 268 points. The difference was statistically significant (p < 0.001), suggesting that the multi-media tablet device was more effective method.

  15. Neonatal postcrania from Mezmaiskaya, Russia, and Le Moustier, France, and the development of Neandertal body form

    PubMed Central

    Weaver, Timothy D.; Coqueugniot, Hélène; Golovanova, Liubov V.; Doronichev, Vladimir B.; Maureille, Bruno; Hublin, Jean-Jacques

    2016-01-01

    Neandertal and modern human adults differ in skeletal features of the cranium and postcranium, and it is clear that many of the cranial differences—although not all of them—are already present at the time of birth. We know less, however, about the developmental origins of the postcranial differences. Here, we address this deficiency with morphometric analyses of the postcrania of the two most complete Neandertal neonates—Mezmaiskaya 1 (from Russia) and Le Moustier 2 (from France)—and a recent human sample. We find that neonatal Neandertals already appear to possess the wide body, long pubis, and robust long bones of adult Neandertals. Taken together, current evidence indicates that skeletal differences between Neandertals and modern humans are largely established by the time of birth. PMID:27217565

  16. Kant, curves and medical learning practice: a reply to Le Morvan and Stock.

    PubMed

    Ives, J

    2007-02-01

    In a recent paper published in the Journal of Medical Ethics, Le Morvan and Stock claim that the kantian ideal of treating people always as ends in themselves and never merely as a means is in direct and insurmountable conflict with the current medical practice of allowing practitioners at the bottom of their "learning curve" to "practise their skills" on patients. In this response, I take up the challenge they issue [corrected] and try to reconcile this conflict. The kantian ideal offered in the paper is an incomplete characterisation of Kant's moral philosophy, and the formula of humanity is considered in isolation without taking into account other salient kantian principles. I also suggest that their argument based on "necessary for the patient" assumes too narrow a reading of "necessary". This reply is intended as an extension to, rather than a criticism of, their work. PMID:17264201

  17. Kant, curves and medical learning practice: a reply to Le Morvan and Stock.

    PubMed

    Ives, J

    2007-02-01

    In a recent paper published in the Journal of Medical Ethics, Le Morvan and Stock claim that the kantian ideal of treating people always as ends in themselves and never merely as a means is in direct and insurmountable conflict with the current medical practice of allowing practitioners at the bottom of their "learning curve" to "practise their skills" on patients. In this response, I take up the challenge they issue [corrected] and try to reconcile this conflict. The kantian ideal offered in the paper is an incomplete characterisation of Kant's moral philosophy, and the formula of humanity is considered in isolation without taking into account other salient kantian principles. I also suggest that their argument based on "necessary for the patient" assumes too narrow a reading of "necessary". This reply is intended as an extension to, rather than a criticism of, their work.

  18. Kant, curves and medical learning practice: a reply to Le Morvan and Stock

    PubMed Central

    Ives, J

    2007-01-01

    In a recent paper published in the Journal of Medical Ethics, Le Morvan and Stock claim that the kantian ideal of treating people always as ends in themselves and never merely as a means is in direct and insurmountable conflict with the current medical practice of allowing practitioners at the bottom of their “learning curve” to “practise their skills” on patients. In this response, I take up the challenge they issue is and try to reconcile this conflict. The kantian ideal offered in the paper is an incomplete characterisation of Kant's moral philosophy, and the formula of humanity is considered in isolation without taking into account other salient kantian principles. I also suggest that their argument based on “necessary for the patient” assumes too narrow a reading of “necessary”. This reply is intended as an extension to, rather than a criticism of, their work. PMID:17264201

  19. Environmental exposure to chromium compounds in the valley of León, México.

    PubMed Central

    Armienta-Hernández, M A; Rodríguez-Castillo, R

    1995-01-01

    The effects on the environment and health of the operation of a chromate compounds factory and tanneries in the León valley in central México are discussed. Sampling and analysis of chromium were performed in water, soil, and human urine. Groundwater has been polluted in an area of about 5 km2 by the leaching of a solid factory waste, which results in concentrations up to 50 mg/l of hexavalent chromium. The plume shape and extension appear to be controlled by the prevailing well extraction regime. Total chromium was detected in the soil around the factory as a result of both aerial transport and deposition of dust produced in the chromate process and irrigation with tannery-contaminated water. Analysis of the impact of chromium in air and water on populations with various degrees of exposure revealed that highly harmful health effects were not observed. PMID:7621799

  20. Qui sera le nouvel Einstein ? Vers une nouvelle theorie de la gravitation

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    1999-10-01

    Un debat de plus d'un siecle a resurgi ces toutes dernieres annees avec une vigueur nouvelle. L'enjeu ? Mettre fin, ni plus ni moins, a l'une des contradictions les plus inouies de la physique fondamentale, en reconciliant mecanique quantique et relativite generale. En effet, a l'heure ou la gravitation semble enfin sur le point de fusionner avec les trois autres forces de la nature. il est certain que la relativite d'Einstein doit etre bientot remplacer par une autre theorie... Reste quye tous les physiciens sont loin de s'accorder sur la marche a suivree. Gravitation quantique, relativite d'echelle, supersymetrie, les candidates ne manquent pas.

  1. Review of the Nearctic genus Lacconotus LeConte (Coleoptera, Mycteridae, Eurypinae)

    PubMed Central

    Pollock, Darren; Majka, Christopher G.

    2012-01-01

    Abstract Lacconotus LeConte, the sole Nearctic representative of the eurypine Mycteridae, is revised, based on morphological features of adults. The following syn. n. is proposed: Lacconotus pallidus Van Dyke, 1928 = Lacconotus pinicola Horn, 1879. The former is a light-colored form with a southern California distribution. A subgen. n., Alcconotus, is described for Lacconotus pinicola, producing the following comb. n.: Lacconotus (Alcconotus) pinicola (Horn). A lectotype is designated for Lacconotus pinicola. A key separating the two subgenera and species is provided, as are photographs and illustrations of salient structures of adults, and maps showing collection localities. Lacconotus punctatus is newly recorded in Alabama, Arkansas, Massachusetts, Oklahoma, Texas, and Wisconsin; Lacconotus pinicola is newly recorded in Arizona and Utah in the USA, and Baja California Norte in Mexico. Phenology information shows a north-to-south gradation in occurrence time. PMID:22303123

  2. [Valutare le esperienze positive e negative: la validazione di una nuova misura del benessere in una popolazione italiana].

    PubMed

    Corno, Giulia; Molinari, Guadalupe; Baños, Rosa Maria

    2016-01-01

    RIASSUNTO. Lo scopo del presente studio è quello di esplorare le proprietà psicometriche di uno strumento di misurazione dell'affetto, la Scala di Esperienze Positive e Negative (SPANE), all'interno di una popolazione italiana. Gli esiti dell'analisi fattoriale confermativa comprovano l'attesa struttura a due fattori, sentimenti positivi e negativi. Le correlazioni con altre dimensioni (per es., ansia, depressione, affetto, aspettative future) confermano i risultati ottenuti con le precedenti versioni della scala: affetto negativo, ansia, depressione e aspettative future negative correlano positivamente con la subscala di esperienze negative e negativamente con la subscala di esperienze positive dello SPANE. In conclusione, i risultati del nostro studio dimostrano che la versione italiana dello SPANE presenta caratteristiche psicometriche simili a quelle mostrate dalla versione orginale e da successive validazioni dello strumento in altre lingue. La scala presenta, inoltre, affidabilità e validità fattoriale. Lo SPANE è un indice utile dal punto di vista clinico che può fornire informazioni rilevanti circa l'esperienza emotiva e il benessere della persona. Nonostante ulteriori studi siano necessari per confermare le caratteristiche psicometriche della scala, la presente validazione della versione italiana dello SPANE può contribuire ad ampliare la ricerca nell'ambito del benessere in una popolazione Italiana. PMID:27362822

  3. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.

    PubMed

    Sallam, Tamer; Jones, Marius C; Gilliland, Thomas; Zhang, Li; Wu, Xiaohui; Eskin, Ascia; Sandhu, Jaspreet; Casero, David; Vallim, Thomas Q de Aguiar; Hong, Cynthia; Katz, Melanie; Lee, Richard; Whitelegge, Julian; Tontonoz, Peter

    2016-06-01

    Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates cholesterol esterification by promoting fatty acid synthesis, and inhibits cholesterol uptake by the low-density lipoprotein receptor. The fact that sterol content is maintained in a narrow range in most cell types and in the organism as a whole suggests that extensive crosstalk between regulatory pathways must exist. However, the molecular mechanisms that integrate LXRs with other lipid metabolic pathways are incompletely understood. Here we show that ligand activation of LXRs in mouse liver not only promotes cholesterol efflux, but also simultaneously inhibits cholesterol biosynthesis. We further identify the long non-coding RNA LeXis as a mediator of this effect. Hepatic LeXis expression is robustly induced in response to a Western diet (high in fat and cholesterol) or to pharmacological LXR activation. Raising or lowering LeXis levels in the liver affects the expression of genes involved in cholesterol biosynthesis and alters the cholesterol levels in the liver and plasma. LeXis interacts with and affects the DNA interactions of RALY, a heterogeneous ribonucleoprotein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the mouse liver. These findings outline a regulatory role for a non-coding RNA in lipid metabolism and advance our understanding of the mechanisms that coordinate sterol homeostasis.

  4. Maxillary sinus recovery and nasal ventilation after Le Fort I osteotomy: a prospective clinical, endoscopic, functional and radiographic evaluation.

    PubMed

    Valstar, M H; Baas, E M; Te Rijdt, J P; De Bondt, B J; Laurens, E; De Lange, J

    2013-11-01

    The condition of the maxillary sinus is not routinely assessed before a Le Fort I osteotomy. Performing this procedure in an infected sinus might account for a considerable proportion of the complications, such as excessive bleeding and sinusitis. The aim of this study was to evaluate the maxillary sinus and nasal ventilation after Le Fort I osteotomy. Twenty patients were evaluated before and 2 months after surgery using validated questionnaires for sinonasal complaints (RSOM-31 and VAS score), nasal endoscopy, peak nasal inspiratory flow (PNIF), and a computed tomography (CT) scan. There were no differences in complaints before and 2 months after surgery (P>0.24). Also, the PNIF did not change significantly (P=0.10). On CT evaluation before surgery, a previously unnoted sinusitis was diagnosed in two patients. Postoperatively, a thickened sinus mucosa was present in all patients near the osteotomy line, the osteosyntheses, and around sequesters. This report describes maxillary sinus evaluation after Le Fort I osteotomy in a more comprehensive way by using CT. The Le Fort I procedure did not influence already existing physical or mental complaints, and nasal ventilation was not negatively affected. However, evaluation of sinonasal pathology should be emphasized in the preoperative work-up.

  5. [Valutare le esperienze positive e negative: la validazione di una nuova misura del benessere in una popolazione italiana].

    PubMed

    Corno, Giulia; Molinari, Guadalupe; Baños, Rosa Maria

    2016-01-01

    RIASSUNTO. Lo scopo del presente studio è quello di esplorare le proprietà psicometriche di uno strumento di misurazione dell'affetto, la Scala di Esperienze Positive e Negative (SPANE), all'interno di una popolazione italiana. Gli esiti dell'analisi fattoriale confermativa comprovano l'attesa struttura a due fattori, sentimenti positivi e negativi. Le correlazioni con altre dimensioni (per es., ansia, depressione, affetto, aspettative future) confermano i risultati ottenuti con le precedenti versioni della scala: affetto negativo, ansia, depressione e aspettative future negative correlano positivamente con la subscala di esperienze negative e negativamente con la subscala di esperienze positive dello SPANE. In conclusione, i risultati del nostro studio dimostrano che la versione italiana dello SPANE presenta caratteristiche psicometriche simili a quelle mostrate dalla versione orginale e da successive validazioni dello strumento in altre lingue. La scala presenta, inoltre, affidabilità e validità fattoriale. Lo SPANE è un indice utile dal punto di vista clinico che può fornire informazioni rilevanti circa l'esperienza emotiva e il benessere della persona. Nonostante ulteriori studi siano necessari per confermare le caratteristiche psicometriche della scala, la presente validazione della versione italiana dello SPANE può contribuire ad ampliare la ricerca nell'ambito del benessere in una popolazione Italiana.

  6. Three-dimensional computed tomographic evaluation of Le Fort III distraction osteogenesis with an external device in syndromic craniosynostosis.

    PubMed

    Wery, M F; Nada, R M; van der Meulen, J J; Wolvius, E B; Ongkosuwito, E M

    2015-03-01

    There is little anteroposterior growth of the midface in patients with syndromic craniosynostosis who are followed up over time without intervention. A Le Fort III with distraction osteogenesis can be done to correct this. This is a controlled way in which to achieve appreciable stable advancement of the midface without the need for bone grafting, but the vector of the movement is not always predictable. The purpose of this study was to evaluate the 3-dimensional effect of Le Fort III distraction osteogenesis with an external frame. Ten patients (aged 7-19 years) who had the procedure were included in the study. The le Fort III procedure and the placement of the external frame were followed by an activation period and then a 3-month retention period. Computed tomographic (CT) images taken before and after operation were converted and loaded into 3-dimensional image rendering software and compared with the aid of a paired sample t test and a colour-coded qualitative analysis. Comparison of the CT data before and after distraction indicated that the amount of midface advancement was significant. Le Fort III distraction osteogenesis is an effective way to advance the midface. However, the movement during osteogenesis is not always exactly in the intended direction, and a secondary operation is often necessary. Three-dimensional evaluation over a longer period of time is necessary.

  7. 78 FR 13665 - L.E. Bell Construction Company, Inc.; Notice of Termination of Exemption by Implied Surrender and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission L.E. Bell Construction Company, Inc.; Notice of Termination of Exemption by... following hydroelectric proceeding has been initiated by the Commission: a. Type of Proceeding:...

  8. Chemical Equilibrium, Unit 2: Le Chatelier's Principle. A Computer-Enriched Module for Introductory Chemistry. Student's Guide and Teacher's Guide.

    ERIC Educational Resources Information Center

    Jameson, A. Keith

    Presented are the teacher's guide and student materials for one of a series of self-instructional, computer-based learning modules for an introductory, undergraduate chemistry course. The student manual for this unit on Le Chatelier's principle includes objectives, prerequisites, pretest, instructions for executing the computer program, and…

  9. In Situ Geochronology on the Mars 2020 Rover with KArLE (Potassium-Argon Laser Experiment)

    NASA Technical Reports Server (NTRS)

    Cohen, B. A.; Swindle, T. D.; Roark, S. E.

    2014-01-01

    If extinct and/or extant life is discovered on Mars, knowledge of the chronology of the biosphere will be of paramount importance. KArLE will provide absolute ages of Mars 2020 rocks, which will allow us to understand them in the context of Mars' geologic history, connect them to other landing sites, and compare Martian epochs of habitability with the Earth's history and evolution of life. KArLE significantly enhances the ability of Mars 2020 to meet its science objectives by performing in situ age dating on key lithologies, enabling targeted searches for ancient biosignatures and increasing the chances of identifying evidence for Martian microbial life. The KArLE investigation makes its measurements on a core sample obtained with the rover drill, inserted into a small, mechanically simple chamber, followed by interrogation by laser-induced breakdown spectroscopy (LIBS), mass spectrometry, and optical imaging. The KArLE experiment is flexible enough to accommodate any partner providing these instrument components, a creative approach that extends the ability of the Mars 2020 payload to accomplish an additional highly-desirable science measurement for low cost and risk and minimal extra hardware.

  10. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.

    PubMed

    Sallam, Tamer; Jones, Marius C; Gilliland, Thomas; Zhang, Li; Wu, Xiaohui; Eskin, Ascia; Sandhu, Jaspreet; Casero, David; Vallim, Thomas Q de Aguiar; Hong, Cynthia; Katz, Melanie; Lee, Richard; Whitelegge, Julian; Tontonoz, Peter

    2016-06-01

    Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates cholesterol esterification by promoting fatty acid synthesis, and inhibits cholesterol uptake by the low-density lipoprotein receptor. The fact that sterol content is maintained in a narrow range in most cell types and in the organism as a whole suggests that extensive crosstalk between regulatory pathways must exist. However, the molecular mechanisms that integrate LXRs with other lipid metabolic pathways are incompletely understood. Here we show that ligand activation of LXRs in mouse liver not only promotes cholesterol efflux, but also simultaneously inhibits cholesterol biosynthesis. We further identify the long non-coding RNA LeXis as a mediator of this effect. Hepatic LeXis expression is robustly induced in response to a Western diet (high in fat and cholesterol) or to pharmacological LXR activation. Raising or lowering LeXis levels in the liver affects the expression of genes involved in cholesterol biosynthesis and alters the cholesterol levels in the liver and plasma. LeXis interacts with and affects the DNA interactions of RALY, a heterogeneous ribonucleoprotein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the mouse liver. These findings outline a regulatory role for a non-coding RNA in lipid metabolism and advance our understanding of the mechanisms that coordinate sterol homeostasis. PMID:27251289

  11. [Some remarks on the theory of sets by Richard Dedekind and Stanisław Leśniewski].

    PubMed

    Obojska, Lidia

    2014-01-01

    Mereology, is a part-whole theory, also called the theory of collective sets. It was founded in 1916 by Stanisław Leśniewski and this is an alternative theory versus the classical set theory by Georg Cantor. These two theories are usually teamed up together as Leśniewski himself was referring to the concept of the set by Cantor and Cantor is considered the "main" ideologist of the set theory. However, when analyzing the original texts of various authors, it seems that the very concept of a collective set is closer to the idea of Richard Dedekind rather than that of Georg Cantor. It is known that Cantor borrowed some concepts on the notion of set from Dedekind, whose ideas were also known to Leśniewski, however, there is no study on this topic. This work is therefore an attempt to compare some set-theoretical concepts of both of these authors, i.e. S. Leśiewski and R. Dedekind and the presentation of their convergence.

  12. Three-dimensional computed tomographic evaluation of Le Fort III distraction osteogenesis with an external device in syndromic craniosynostosis.

    PubMed

    Wery, M F; Nada, R M; van der Meulen, J J; Wolvius, E B; Ongkosuwito, E M

    2015-03-01

    There is little anteroposterior growth of the midface in patients with syndromic craniosynostosis who are followed up over time without intervention. A Le Fort III with distraction osteogenesis can be done to correct this. This is a controlled way in which to achieve appreciable stable advancement of the midface without the need for bone grafting, but the vector of the movement is not always predictable. The purpose of this study was to evaluate the 3-dimensional effect of Le Fort III distraction osteogenesis with an external frame. Ten patients (aged 7-19 years) who had the procedure were included in the study. The le Fort III procedure and the placement of the external frame were followed by an activation period and then a 3-month retention period. Computed tomographic (CT) images taken before and after operation were converted and loaded into 3-dimensional image rendering software and compared with the aid of a paired sample t test and a colour-coded qualitative analysis. Comparison of the CT data before and after distraction indicated that the amount of midface advancement was significant. Le Fort III distraction osteogenesis is an effective way to advance the midface. However, the movement during osteogenesis is not always exactly in the intended direction, and a secondary operation is often necessary. Three-dimensional evaluation over a longer period of time is necessary. PMID:25605236

  13. Un cas de leishmaniose féline disséminée dans le sud de la France

    PubMed Central

    Pocholle, E.; Reyes-Gomez, E.; Giacomo, A.; Delaunay, P.; Hasseine, L.; Marty, P.

    2012-01-01

    Cet article rapporte un cas de leishmaniose féline disséminée chez un chat (Felis catus) de 14 ans, séropositif pour le FIV et vivant dans les Alpes-Maritimes (sud de la France). Le chat présente des papules érythémateuses ulcérées sur la face et l’encolure, et une lésion proliférative ulcérée sur l’oreille gauche. C’est l’examen histopathologique des lésions cutanées qui permet le diagnostic d’une leishmaniose disséminée, associée à un carcinome épidermoïde de l’oreille. 100 mg d’allopurinol administrés une fois par jour per os pendant quatre mois ont permis la rémission totale des lésions cutanées. Des prélèvements post mortem ont révélé la persistance du parasite dans l’organisme après six mois de traitement. Cet article discute de la sensibilité du chat à la leishmaniose et de son rôle potentiel de réservoir. PMID:22314243

  14. 78 FR 72745 - Bureau of Political-Military Affairs; Administrative Debarment of LeAnne Lesmeister Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... of Political-Military Affairs; Administrative Debarment of LeAnne Lesmeister Under the Arms Export... CONTACT: Sue Gainor, Director, Office of Defense Trade Controls Compliance, Bureau of Political-Military... services. Section 127.7(a) of the ITAR authorizes the Assistant Secretary of State for...

  15. Produce Live News Broadcasts Using Standard AV Equipment: A Success Story from the Le Center High School in Minnesota.

    ERIC Educational Resources Information Center

    Rostad, John

    1997-01-01

    Describes the production of news broadcasts on video by a high school class in Le Center, Minnesota. Topics include software for Apple computers, equipment used, student responsibilities, class curriculum, group work, communication among the production crew, administrative and staff support, and future improvements. (LRW)

  16. Redistribution of flexibility in stabilizing antibody fragment mutants follows Le Châtelier's principle.

    PubMed

    Li, Tong; Tracka, Malgorzata B; Uddin, Shahid; Casas-Finet, Jose; Jacobs, Donald J; Livesay, Dennis R

    2014-01-01

    Le Châtelier's principle is the cornerstone of our understanding of chemical equilibria. When a system at equilibrium undergoes a change in concentration or thermodynamic state (i.e., temperature, pressure, etc.), La Châtelier's principle states that an equilibrium shift will occur to offset the perturbation and a new equilibrium is established. We demonstrate that the effects of stabilizing mutations on the rigidity ⇔ flexibility equilibrium within the native state ensemble manifest themselves through enthalpy-entropy compensation as the protein structure adjusts to restore the global balance between the two. Specifically, we characterize the effects of mutation to single chain fragments of the anti-lymphotoxin-β receptor antibody using a computational Distance Constraint Model. Statistically significant changes in the distribution of both rigidity and flexibility within the molecular structure is typically observed, where the local perturbations often lead to distal shifts in flexibility and rigidity profiles. Nevertheless, the net gain or loss in flexibility of individual mutants can be skewed. Despite all mutants being exclusively stabilizing in this dataset, increased flexibility is slightly more common than increased rigidity. Mechanistically the redistribution of flexibility is largely controlled by changes in the H-bond network. For example, a stabilizing mutation can induce an increase in rigidity locally due to the formation of new H-bonds, and simultaneously break H-bonds elsewhere leading to increased flexibility distant from the mutation site via Le Châtelier. Increased flexibility within the VH β4/β5 loop is a noteworthy illustration of this long-range effect.

  17. Prevalence of diarrhoeagenic Escherichia coli in children from León, Nicaragua.

    PubMed

    Vilchez, Samuel; Reyes, Daniel; Paniagua, Margarita; Bucardo, Filemon; Möllby, Roland; Weintraub, Andrej

    2009-05-01

    Diarrhoeal disease is a public health problem worldwide, mostly affecting children in developing countries. In Nicaragua, diarrhoea is the second greatest cause of infant mortality. During the period March 2005 to September 2006, a total of 526 faecal samples from children aged 0-60 months (381 with and 145 without diarrhoea) from León, Nicaragua, were studied. In order to detect five different diarrhoeagenic Escherichia coli pathotypes simultaneously [enterotoxigenic E. coli (ETEC), enteroaggregative E. coli (EAEC), enteropathogenic E. coli (EPEC), enterohaemorrhagic E. coli (EHEC) and enteroinvasive E. coli (EIEC)], a mixture of eight primer pairs was used in a single PCR. At least one diarrhoeagenic E. coli pathotype was detected in 205 samples (53.8%) of the diarrhoea group and in 77 samples (53.1%) in the non-diarrhoea group. ETEC was detected significantly more often in children with diarrhoea (20.5%) than in children without diarrhoea (8.3%) (P=0.001). Atypical EPEC, EIEC and EAEC were detected with slightly lower frequencies in children with (16.0, 0.8 and 27.8%, respectively) than in children without (20.7, 1.4 and 33.1%, respectively) diarrhoea. EHEC was only detected in children with diarrhoea (2.1%). In conclusion, ETEC continues to be an important agent associated with diarrhoea in children from León, Nicaragua. Although not very frequent, the only findings that were 100% associated with diarrhoea were ETEC estA (4.7%) and EHEC (2.1%). Nevertheless, EAEC and EPEC were also frequent pathotypes in the population under study. In children with severe diarrhoea, more than half had EAEC, ETEC or EPEC, and EAEC was the most prevalent pathotype.

  18. Redistribution of flexibility in stabilizing antibody fragment mutants follows Le Châtelier's principle.

    PubMed

    Li, Tong; Tracka, Malgorzata B; Uddin, Shahid; Casas-Finet, Jose; Jacobs, Donald J; Livesay, Dennis R

    2014-01-01

    Le Châtelier's principle is the cornerstone of our understanding of chemical equilibria. When a system at equilibrium undergoes a change in concentration or thermodynamic state (i.e., temperature, pressure, etc.), La Châtelier's principle states that an equilibrium shift will occur to offset the perturbation and a new equilibrium is established. We demonstrate that the effects of stabilizing mutations on the rigidity ⇔ flexibility equilibrium within the native state ensemble manifest themselves through enthalpy-entropy compensation as the protein structure adjusts to restore the global balance between the two. Specifically, we characterize the effects of mutation to single chain fragments of the anti-lymphotoxin-β receptor antibody using a computational Distance Constraint Model. Statistically significant changes in the distribution of both rigidity and flexibility within the molecular structure is typically observed, where the local perturbations often lead to distal shifts in flexibility and rigidity profiles. Nevertheless, the net gain or loss in flexibility of individual mutants can be skewed. Despite all mutants being exclusively stabilizing in this dataset, increased flexibility is slightly more common than increased rigidity. Mechanistically the redistribution of flexibility is largely controlled by changes in the H-bond network. For example, a stabilizing mutation can induce an increase in rigidity locally due to the formation of new H-bonds, and simultaneously break H-bonds elsewhere leading to increased flexibility distant from the mutation site via Le Châtelier. Increased flexibility within the VH β4/β5 loop is a noteworthy illustration of this long-range effect. PMID:24671209

  19. The "Le Chatelier's principle"-governed response of actin filaments to osmotic stress.

    PubMed

    Ito, Tadanao; Yamazaki, Masahito

    2006-07-13

    Actin filaments inhibit osmotic stress-driven water flow across a semipermeable membrane in proportion to the filament concentration (Ito, T.; Zaner, K. S.; Stossel, T. P. Biophys. J. 1987, 51, 745). When the filaments are cross-linked by F-actin binding protein, filamin A, this flow is stopped completely (Ito, T.; Suzuki, A.; Stossel, T. P. Biophys. J. 1992, 61, 1301). No conventional theory accurately accounts for these results. Here, this response is analyzed by formulating the entropy of the system under osmotic stress. Results demonstrate that the response of the actin filaments to osmotic stress is governed by the Le Chatelier's principle, which states that an external interaction that disturbs the equilibrium brings about processes in the body that tend to reduce the effects of this interaction. In the present case, disrupting equilibrium by osmotic stress brings about a reaction that decreases the chemical potential of water in the F-actin solution, reducing the effect of the applied osmotic disturbance. This decrease in the chemical potential of the water in the F-actin solution is caused by an increase in the chemical potential of F-actin, which is induced by isothermal absorption of heat by F-actin aided by work done by osmotic stress. As a result, F-actin has an inhibitory effect on the osmotic stress-driven water flow, and can even completely stop the flow when it is cross-linked. This is the first report demonstrating that the Le Chatelier's principle applies to the reaction of biopolymers against equilibrium disturbances such as osmotic stress. PMID:16821884

  20. Redistribution of Flexibility in Stabilizing Antibody Fragment Mutants Follows Le Châtelier’s Principle

    PubMed Central

    Li, Tong; Tracka, Malgorzata B.; Uddin, Shahid; Casas-Finet, Jose; Jacobs, Donald J.; Livesay, Dennis R.

    2014-01-01

    Le Châtelier’s principle is the cornerstone of our understanding of chemical equilibria. When a system at equilibrium undergoes a change in concentration or thermodynamic state (i.e., temperature, pressure, etc.), La Châtelier’s principle states that an equilibrium shift will occur to offset the perturbation and a new equilibrium is established. We demonstrate that the effects of stabilizing mutations on the rigidity ⇔ flexibility equilibrium within the native state ensemble manifest themselves through enthalpy-entropy compensation as the protein structure adjusts to restore the global balance between the two. Specifically, we characterize the effects of mutation to single chain fragments of the anti-lymphotoxin-β receptor antibody using a computational Distance Constraint Model. Statistically significant changes in the distribution of both rigidity and flexibility within the molecular structure is typically observed, where the local perturbations often lead to distal shifts in flexibility and rigidity profiles. Nevertheless, the net gain or loss in flexibility of individual mutants can be skewed. Despite all mutants being exclusively stabilizing in this dataset, increased flexibility is slightly more common than increased rigidity. Mechanistically the redistribution of flexibility is largely controlled by changes in the H-bond network. For example, a stabilizing mutation can induce an increase in rigidity locally due to the formation of new H-bonds, and simultaneously break H-bonds elsewhere leading to increased flexibility distant from the mutation site via Le Châtelier. Increased flexibility within the VH β4/β5 loop is a noteworthy illustration of this long-range effect. PMID:24671209

  1. Séroprévalence de l’AgHBs chez la femme enceinte dans le centre du Maroc

    PubMed Central

    Sbiti, Mohammed; Khalki, Hanane; Benbella, Imane; louzi, Lhoussaine

    2016-01-01

    La transmission materno-fœtale du virus de l'hépatite B (VHB) est un problème qui préoccupe toujours les autorités sanitaires à travers le monde et suscite la mise en place de mesures préventives renforcées. Le statut réplicatif du virus chez la mère séropositive, évalué par la positivité de l'AgHbe et le taux de la charge virale, conditionne le risque de contamination qui est plus important en période péri-natale. Les mères porteuses chroniques du VHB constituent un véritable réservoir de la transmission verticale de cette infection. Nous avons étudié, à travers cette enquête sur 1120 femmes enceintes Marocaines, la séroprévalence de l'AgHBs qui était de 2,35%, dans le but d'alimenter les données nationales sur ce sujet. Parmi ces femmes séropositives pour l'AgHBs, 79,1% avaient un AgHBe négatif et ont bénéficié d'une recherche moléculaire qui s'est révélée positive dans 89,4% des cas. La vaccination de la femme en âge de procréer est l'un des piliers majeurs de la prévention de la transmission verticale du VHB, seulement 2,4% de nos patientes étaient vaccinées. Ceci relève l'intérêt du dépistage au cours de la grossesse, qui doit se focaliser sur la sensibilisation à la vaccination de femmes séronégatives, et le suivi par biologie moléculaire des mères séropositives dans le but d'instaurer un traitement prophylactique adéquat. PMID:27795784

  2. Imagerie Resolue dans le Temps des Photons et Neutres Metastables Emis D'une Surface Par Stimulation Electronique

    NASA Astrophysics Data System (ADS)

    Leclerc, Gregoire

    L'appareil que nous presentons ici a ete mis au point pour permettre d'accumuler des images numeriques, resolues dans le temps, de la desorption par stimulation electronique (DSE) d'ions positifs et negatifs, de photons et de neutres metastables, tout en conservant des capacites de base de diffraction d'electrons lents (DEL) et de transmission d'electrons lents (TEL). Le spectrometre comporte un monochromateur d'electrons a secteur cylindrique de 127^ circ dont l'optique de sortie permet la focalisation du faisceau d'electrons sur une large gamme d'energies. Le detecteur consiste en un empilement de galettes de microcanaux et d'une anode resistive a encodage de division de charges. La reponse spatiale du detecteur a ete calibree et plusieurs causes de non-linearite ont ete localisees et corrigees. Des methodes de correction materielle et logicielle des distorsions spatiales sont presentees. La resolution temporelle des evenements est obtenue en pulsant le faisceau d'electrons, et de facon synchrone la detection, laquelle est couplee a un micro-ordinateur. La premiere partie de ce travail est consacree a la caracterisation du spectrometre et la presentation de nombreux parametres operationnels, obtenus soit au moment de la conception, soit experimentalement. Suit la presentation de donnees de DEL et de DSE pour le systeme Ar/Pt(111) en films minces a 15K. Les sequences temporelles d'images de metastables d'Ar desorbes ont revele la presence de plusieurs populations distinctes, ayant des distributions angulaires et distributions d'energie cinetique que nous avons pu separer. Les fonctions d'excitation de l'emission de photons et de la desorption de differentes composantes de metastables, ainsi que la dependance de ces signaux sur l'epaisseur des films d'Ar, sont aussi presentees et analysees. Les techniques que nous avons developpees ont permis de cerner les mecanismes en jeu pour la desorption et la luminescence.

  3. The Coiled-Coil Domain of EHD2 Mediates Inhibition of LeEix2 Endocytosis and Signaling

    PubMed Central

    Bar, Maya; Sharfman, Miya; Schuster, Silvia; Avni, Adi

    2009-01-01

    Endocytosis has been suggested to be crucial for the induction of plant immunity in several cases. We have previously shown that two Arabidopsis proteins, AtEHD1 and AtEHD2, are involved in endocytosis in plant systems. AtEHD2 has an inhibitory effect on endocytosis of transferrin, FM-4-64, and LeEix2. There are many works in mammalian systems detailing the importance of the various domains in EHDs but, to date, the domains of plant EHD2 that are required for its inhibitory activity on endocytosis remained unknown. In this work we demonstrate that the coiled-coil domain of EHD2 is crucial for the ability of EHD2 to inhibit endocytosis in plants, as mutant EHD2 forms lacking the coiled-coil lost the ability to inhibit endocytosis and signaling of LeEix2. The coiled-coil was also required for binding of EHD2 to the LeEix2 receptor. It is therefore probable that binding of EHD2 to the LeEix2 receptor is required for inhibition of LeEix2 internalization. We also show herein that the P-loop of EHD2 is important for EHD2 to function properly. The EH domain of AtEHD2 does not appear to be involved in inhibition of endocytosis. Moreover, AtEHD2 influences actin organization and may exert its inhibitory effect on endocytosis through actin re-distribution. The coiled-coil domain of EHD2 functions in inhibition of endocytosis, while the EH domain does not appear to be involved in inhibition of endocytosis. PMID:19936242

  4. Who invented the mule deer (Odocoileus hemionus)? On the authorship of the fraudulent 1812 journal of Charles Le Raye

    USGS Publications Warehouse

    Woodman, Neal

    2015-01-01

    The captivity journal of Charles Le Raye was first published in 1812 as a chapter in A topographical description of the state of Ohio, Indiana Territory, and Louisiana, a volume authored anonymously by a late officer in the U. S. Army. Le Raye was purported to be a French Canadian fur trader who, as a captive of the Sioux, had travelled across broad portions of the Missouri and Yellowstone river drainages a few years before the Lewis and Clark expedition (1804-1806), and his account of the land, its people, and its natural resources was relied upon as a primary source by generations of natural historians, geographers, and ethnographers. Based directly on descriptions of animals in the published journal, the naturalist Constantine S. Rafinesque named seven new species of North American mammals, including what are currently recognized as the mule deer (Odocoileus hemionus) and a Great Plains subspecies of white-tailed deer (O. virginianus macrourus). Unfortunately, Le Raye never existed, and historical, geographical, and ethnographical evidence indicates that the journal is fraudulent. Determining the author of this work is relevant to identifying the sources used to construct it, which may help us to understand the real animals upon which Rafinesque's species are based. Traditionally, authorship of the volume was attributed to Jervis Cutler, but his role in composing the fraudulent Le Raye journal has been called into question. In this paper, I present additional evidence supporting the hypothesis that Jervis Cutler bears primary responsibility for the Le Raye journal and that he had the background, opportunity, and potential motive to author it.

  5. The coiled-coil domain of EHD2 mediates inhibition of LeEix2 endocytosis and signaling.

    PubMed

    Bar, Maya; Sharfman, Miya; Schuster, Silvia; Avni, Adi

    2009-01-01

    Endocytosis has been suggested to be crucial for the induction of plant immunity in several cases. We have previously shown that two Arabidopsis proteins, AtEHD1 and AtEHD2, are involved in endocytosis in plant systems. AtEHD2 has an inhibitory effect on endocytosis of transferrin, FM-4-64, and LeEix2. There are many works in mammalian systems detailing the importance of the various domains in EHDs but, to date, the domains of plant EHD2 that are required for its inhibitory activity on endocytosis remained unknown. In this work we demonstrate that the coiled-coil domain of EHD2 is crucial for the ability of EHD2 to inhibit endocytosis in plants, as mutant EHD2 forms lacking the coiled-coil lost the ability to inhibit endocytosis and signaling of LeEix2. The coiled-coil was also required for binding of EHD2 to the LeEix2 receptor. It is therefore probable that binding of EHD2 to the LeEix2 receptor is required for inhibition of LeEix2 internalization. We also show herein that the P-loop of EHD2 is important for EHD2 to function properly. The EH domain of AtEHD2 does not appear to be involved in inhibition of endocytosis. Moreover, AtEHD2 influences actin organization and may exert its inhibitory effect on endocytosis through actin re-distribution. The coiled-coil domain of EHD2 functions in inhibition of endocytosis, while the EH domain does not appear to be involved in inhibition of endocytosis. PMID:19936242

  6. Le phéochromocytome surrénalien bilatéral: à propos d'un cas

    PubMed Central

    Eya, Cherif; Lamia, Ben Hassine; Samira, Azzabi; Zouleikha, Kaouech; Imen, Boukhris; Chekib, Kooli; Narjess, Khalfallah

    2013-01-01

    Les phéochromocytomes de localisation bilatérale sont rares. Ils s'intègrent le plus souvent dans le cadre d'une maladie familiale. Néanmoins des formes bilatérales sporadiques peuvent être observées. Ainsi, chez tout patient présentant des masses surrénaliennes bilatérales, un phéochromocytome bilatéral doit être suspecté et son caractère familial ou sporadique doit être déterminé devant le risque de récidive tumorale. A ce propos, nous rapportons l'observation d'une patiente âgée de 22 ans qui a été hospitalisée pour exploration d'une hypertension artérielle de découverte récente. L'association à des céphalées, sueurs et palpitations a orienté vers le diagnostic de phéochromocytome. Les taux urinaires des dérivés méthoxylés étaient très élevés. L’échographie et l'IRM abdominales ont noté la présence de deux masses surrénaliennes bilatérales. La scintigraphie au MIBG a montré une hyperfixation au niveau des deux surrénales, sans autres localisations. L'enquête à la recherche d'une néoplasie endocrinienne multiple ou d'une phacomatose était négative. Le traitement a consisté en une surrénalectomie bilatérale par voie cœlioscopique. L’évolution sous traitement substitutif par hydrocortisone était favorable avec une normalisation des chiffres tensionnels. PMID:24244787

  7. LeERF-1, a novel AP2/ERF family gene within the B3 subcluster, is down-regulated by light signals in Lithospermum erythrorhizon.

    PubMed

    Zhang, W; Zou, A; Miao, J; Yin, Y; Tian, R; Pang, Y; Yang, R; Qi, J; Yang, Y

    2011-03-01

    We previously showed that ethylene might be involved in the process of shikonin biosynthesis regulated by light signals. Here, we cloned a full-length cDNA of LeERF-1, a putative ethylene response factor gene, from Lithospermum erythrorhizon using the RACE (rapid amplification of cDNA ends) method. Phylogenetic analysis revealed that LeERF-1 was classified in the B3 subfamily, together with ERF1 and ORA59 of Arabidopsis. Heterologous expression of LeERF-1 in Arabidopsis showed that LeERF-1:eGFP fusion protein was precisely localised to the nucleus, implying that it might function as a transcription factor. Detailed expression analysis with real-time PCR showed that LeERF-1 was significantly down-regulated by white, blue and red light, although the inhibitory effect of red light was relatively weak compared to other light conditions. Tissue-specific expression analysis also indicated that LeERF-1 was dominantly expressed in the roots, which grow in soil in darkness. These patterns are all consistent with the effects of different light signals on regulating formation of shikonin and its derivatives, indicating that LeERF-1 might be a crucial positive regulator, like other B3 subfamily proteins (such as ORCA3 and ORA59), in regulating biosynthesis of secondary metabolites.

  8. Enormes incidentalomes surrénaliens: rôle de l'imagerie médicale à propos de deux cas

    PubMed Central

    Nikièma, Zakari; Yaméogo, Aimé Arsène; N'Goran, Kouamé; Cissé, Rabiou

    2012-01-01

    Les auteurs rapportent une série de deux cas d’énormes incidentalomes surrénaliens rarement observés dans la littérature. Ils étaient de siège bilatéral dans le premier cas et unilatéral droit dans le second. Si le diagnostic étiologique est parfois aisé dans les pays à haute technologie médicale, il pose un problème majeur dans certaines structures sanitaires des pays à ressources limitées. Lele essentiel de l'imagerie est d’établir de manière précise, peu invasive et peu coûteuse que possible, la nature bénigne ou maligne de l'incidentalome surrénalien. L’échographie et la tomodensitométrie ont permis de faire le diagnostic positif chez nos patients. La sémiologie tomodensitométrique est caractéristique quand elle associe la morpho-structure de la masse et deux critères majeurs basés d'une part sur l'histologie et la physiologie et d'autre part la cinétique de rehaussement de la masse après injection de produit de contraste. Toutefois, la biologie et surtout la biopsie assurent le diagnostic étiologique. PMID:23396505

  9. Le méningiome du sinus maxillaire: à propos d'un cas avec revue de la littérature

    PubMed Central

    Mezouri, Imane; Bellefqih, Sara; Chenna, Hanane; El Kacemi, Hanan; Kebdani, Tayeb; Benjaafar, Noureddine

    2014-01-01

    Les méningiomes extracrâniens sont rares, leur localisation au niveau du sinus maxillaire est exceptionnelle. Nous rapportons le cas d'une patiente âgée de 41 ans, ayant présenté une exophtalmie avec des céphalées intermittentes évoluant depuis 8 ans. Le diagnostic a été retenu à partir de la biopsie et du scanner cérébral et du massif facial. Le traitement a consisté en une irradiation exclusive à la dose de 54 Gray (Gy). La patiente est restée en bon contrôle locorégional, après un recul de 18 mois. A travers ce cas clinique on a démontré que le sinus maxillaire peut être touché par le méningiome, et qu'il doit être inclus dans le diagnostic différentiel des tumeurs des tissus mous. PMID:25419275

  10. La recherche de naines brunes autour d'etoiles du voisinage solaire et le spectrographe multi-objets SIMON

    NASA Astrophysics Data System (ADS)

    Albert, Loic

    Cette thèse comporte un volet d'instrumentation astronomique, le spectrographe infrarouge SIMON, et un volet de recherche, la recherche de naines brunes autour d'étoiles (lu voisinage solaire. Le premier volet fait état de la construction du Spectrographe infrarouge de Montréal (SIMON), un instrument polyvalent fonctionnant dans le proche infrarouge (0.8-2.5 [mu]m) conçu pour être utilisé à l'Observatoire du mont Mégantic (OMM) et au télescope Canada-France-Hawaii (TCFH). SIMON regroupe plusieurs fonctionnalités: l'irnagerie, la spectroscopie, la spectroscopie rnulti-objets et la polarimétrie. Comme imageur, il offre un champ de vue (le 7.7'x 7.7' à l'OMM et 3.3' x 3.3' au TCFH et possède huit filtres dont un filtre I . SIMON compte trois disperseurs pour la spectroscopie: (1) un prisme d'Amici R max [approximate]50, 0.8-2.5 [mu]m); (2) un grism de silice (R max [approximate]750, 1.17-2.34 [mu]m); et un grism de KRS-5 (R max [approximate]3000, bande J,H ou K S ). Le mode spectroscopique multi-objets utilise des masques cryogéniques placés dans un second cryostat et, couplé au prisme d'Amici, permet l'obtention d'une centaine de spectres simultanément. Le mode polarimétrique permet l'observation de quatre vecteurs de polarisation simultanément. Cette première moitié de thèse étaye les objectifs scientifiques, détaille la conception optique (collimatrice et caméra) et mécanique (un cryostat principal contenant trois cotres à filtres et le détecteur, un cryostat amovible contenant nue roue à masques), décrit l'électronique et le système d'acquisition, et enfin présente les performances dans les différents modes. Le second volet de cette thèse est un relevé grand champ à la recherche de naines brunes de type T autour de 66 étoiles du voisinage solaire. Il a été effectué en utilisant des caméras infrarouges (dont SIMON) et des CCD sur divers télescopes. Le diagramme I--J vs. J--H utilisé est. efficace pour isoler des naines T

  11. Le don après un décès d'origine cardiocirculatoire au Canada

    PubMed Central

    Shemie, Sam D.; Baker, Andrew J.; Knoll, Greg; Wall, William; Rocker, Graeme; Howes, Daniel; Davidson, Janet; Pagliarello, Joe; Chambers-Evans, Jane; Cockfield, Sandra; Farrell, Catherine; Glannon, Walter; Gourlay, William; Grant, David; Langevin, Stéphan; Wheelock, Brian; Young, Kimberly; Dossetor, John

    2006-01-01

    Résumé Ces recommandations sont le fruit d'un processus multidisciplinaire national ayant duré un an et visant à déterminer si et comment l'on pourrait procéder au don d'organes après un décès d'origine cardiocirculatoire («don après le décès cardiocirculatoire», ou DDC) au Canada. Le forum national organisé en février 2005 a permis aux participants de discuter et d'élaborer des recommandations sur les principes, interventions et pratiques se rapportant au DDC. Les aspects éthiques et juridiques ont été abordés dans les discussions. À la fin du Forum, la majorité des participants ont été favorables à l'implantation de programmes de DDC au Canada. Les participants du Forum ont également convenu qu'il fallait formuler et prôner des valeurs fondamentales pour orienter l'élaboration de programmes et de protocoles basés sur le cadre médical, éthique et juridique établi lors de cette réunion. Même si la possibilité d'un don d'organes et de tissus doit faire partie intégrante des soins de fin de vie, il faut insister sur le fait que le devoir de diligence envers les patients mourants et leurs familles doit demeurer la priorité des équipes soignantes. La complexité et les répercussions profondes du décès sont reconnues et doivent être respectées, de même que les différences personnelles, ethnoculturelles et religieuses face à la mort et au don d'organes. Les décisions d'arrêter le traitement de maintien des fonctions vitales, la prise en charge des derniers moments de la vie et le diagnostic de décès selon des critères cardiocirculatoires doivent être distincts et indépendants des processus de don et transplantation. Ce rapport contient des recommandations destinées aux gestionnaires de program, aux autorités sanitaires régionales et aux instances appelés à élaborer les protocoles de DDC. Les programmes doivent être conçus en fonction des éléments suivants : direction et planification locales, éducation et

  12. Use of a simple handmade retractor to protect the descending palatine artery during removal of posterior osseous interferences for maxillary impaction in Le Fort I osteotomy.

    PubMed

    Omura, Susumu; Iwai, Toshinori; Murata, Shogo; Tohnai, Iwai

    2013-05-01

    For accurate superior or posterior repositioning of the maxilla in Le Fort I osteotomy, bone removal around the descending palatine artery (DPA) and maxillary tuberosity is required. Because the most common site of hemorrhage in the Le Fort I osteotomy is the posterior maxilla, this bone removal provides surgeons to surgical frustration of DPA injury. When the DPA is injured during the bone removal and the ligation is performed, aseptic necrosis of the maxilla may occur. Therefore, we report the use of a simple handmade retractor to protect the DPA in Le Fort I osteotomy.

  13. Ensemble des troubles causés par l'alcoolisation fœtale : lignes directrices canadiennes concernant le diagnostic

    PubMed Central

    Chudley, Albert E.; Conry, Julianne; Cook, Jocelynn L.; Loock, Christine; Rosales, Ted; LeBlanc, Nicole

    2005-01-01

    Résumé LE DIAGNOSTIC DE L'ENSEMBLE DES TROUBLES CAUSÉS PAR L'ALCOOLISATION FÉTALE (ETCAF) est complexe et l'élaboration de lignes directrices concernant le diagnostic est justifiée. Un sous-comité du Comité consultatif national de l'Agence de santé publique du Canada sur l'Ensemble des troubles causés par l'alcoolisation fœtale a examiné, analysé et intégré les méthodes de diagnostic actuelles afin de parvenir à une méthode de diagnostic normalisée faisant le consensus au Canada. L'objet du présent document est d'examiner et de clarifier l'utilisation des systèmes de diagnostic actuels et de formuler des recommandations quant à leur application pour le diagnostic des déficiences liées à l'ETCAF chez des individus de tous les âges. Les lignes directrices sont fondées sur un vaste consensus de praticiens et d'autres intervenants spécialisés dans le domaine. Ces lignes directrices ont été organisées en sept catégories, soit le dépistage et l'orientation vers les spécialistes, l'examen physique et le diagnostic différentiel, l'évaluation du comportement neurologique, le traitement et le suivi, les antécédents de consommation d'alcool de la mère pendant la grossesse, les critères du diagnostic pour le syndrome d'alcoolisation fœtale (SAF), SAF partiel et troubles neurologiques du développement liés à l'alcool, l'harmonisation de l'Institute of Medicine (IOM) et des approches du Code diagnostique à 4 chiffres. Le diagnostic exige une évaluation complète des antécédents, ainsi qu'un examen physique et du comportement neurologique, tout en recourant à une approche multidisciplinaire. Les présentes lignes directrices pour le diagnostic du syndrome d'alcoolisation fœtale et des déficiences qui y sont associées sont les premières à avoir été élaborées au Canada et elles sont fondées sur la consultation d'un grand éventail de spécialistes du diagnostic.

  14. Apport de l'orientation clinique dans le diagnostic des hypertensions arterielles endocriniennes

    PubMed Central

    El Aziz, Siham; Chadli, Asma; Louda, Fatima; El Ghomari, Hassan; Farouqi, Ahmed

    2014-01-01

    L'hypertension artérielle d'origine endocrinienne représente une cause curable d'hypertension artérielle (HTA), ce qui en justifie le dépistage. Une orientation clinique est souhaitable afin de prescrire les bilans adéquats, notamment dans les pays en voie de développement. L'objectif de notre étude est décrire les aspects cliniques des patients ayant une HTA endocrinienne diagnostiquée au CHU de Casablanca. Méthodes: Il s'agit d'une étude descriptive rétrospective de 2004 à 2011, incluant tout patient ayant une HTA endocrinienne (en dehors des dysthyroïdies) admis en Endocrinologie. Les données concernant les facteurs cliniques, paracliniques et thérapeutiques ont été colligées. Au cours de la période étudiée, 53 cas d'HTA endocrinienne ont été admis, avec une age moyen au diagnostic de 39,3 ans et un sex-ratio F/H de 3,9. Trente patients (56.6%) ont un age ont un âge inférieur à 40 ans. On ne retrouve pas d'hérédité tensionelle chez 88.7% des patients. Les étiologies sont le Syndrome de cushing (41.5%), le phéochromocytome (32%), les adénomes somatotropes (15%) et les hyperaldostéronismes primaire (7.5%). L'HTA est essentiellement de grade un ou deux (69.8%), avec un retentissement cardio-vasculaire chez 11 patients (20.7%). Les patients ayant un SC avaient tous des signes cutanés spécifiques. Il s'agissait de sujets jeunes avec plusieurs facteurs de risque cardiovasculaire. Nous avons retrouvé un amaigrissement chez 37.5% des patients ayant un phéochromocytome avec un indice de masse corporel moyen de 20 kg/m2. L'HTA était permanente dans 5 cas de phéochromocytomes. Il n'existait pas d'hypokaliémie chez 50% des patients ayant un hyperaldostéronisme. Les signes cliniques des patients ayant une acromégalie étaient francs, avec un age moyen plus élevé de 50 ans. Nous avons noté une régression de l'HTA chez 59% de ces patients après guérison de l'endocrinopathie en cause. Plusieurs signes cliniques peuvent nous

  15. Effet de l'interaction coulombienne sur la localisation d'Anderson dans le gaz bidimensionnel d'électrons

    NASA Astrophysics Data System (ADS)

    Fleury, G.

    2010-09-01

    Nous étudions l’effet des interactions coulombiennes sur la localisation d’Anderson dans le gaz bidimensionnel d’électrons désordonné. L’objectif est de statuer sur la question de l’existence de métaux à deux dimensions. En l’absence d’interaction, la théorie d’échelle de la localisation prédit qu’un désordre infinitésimal suffit à localiser la fonction d’onde électronique et donc à rendre le système isolant à température nulle (Abrahams et al., 1979). Dans certaines limites extrêmes, les interactions peuvent être prises en compte et l’on aboutit également à un état isolant. Cependant, aucune théorie analytique ne permet de traiter le régime quantique non-perturbatif où désordre et interaction sont intermédiaires. Expérimentalement, il est possible de l’explorer dans des échantillons de haute mobilité et basse densité. Depuis 1994, des comportements métalliques inexpliqués y ont été observés (Kravchenko et al., 1994). Nous avons mis au point une méthode numérique permettant d’étudier le problème couplé de la localisation d’Anderson en présence d’interaction. Cette méthode mêle Monte Carlo quantique à température nulle et théorie d’échelle pour la conductance de Thouless. Nous trouvons que la théorie d’échelle de la localisation est préservée en présence d’interaction et donc que le gaz bidimensionnel, même corrélé, est isolant à température nulle. Nos résultats montrent de plus que les interactions délocalisent le gaz bidimensionnel et que cet effet de délocalisation est accru en présence de dégénérescence de vallées. Ils nous permettent de proposer un mécanisme simple rendant compte des principales caractéristiques des comportements métalliques observés expérimentalement.

  16. Les astronomes européens auscultent les cieux avec le plus grand télescope du monde

    NASA Astrophysics Data System (ADS)

    Malbet, F.

    2008-09-01

    À l'heure des projets de télescopes extrêmement grands, l'Europe a déjà une longueur d'avance. Le télescope européen (VLT), en mode interférométrique avec l'instrument AMBER devient le plus grand télescope jamais utilisé dans le domaine optique aussi bien en surface de miroir (plus de 150 m2) qúen finesse de résolution qui atteint celle d'un télescope de 130 m de diamètre. Le journal professionnel Astronomy & Astrophysics a publié en 2007 un numéro spécial qui rapporte les premiers résultats obtenus avec l'instrument AMBER (Astronomical MultiBEam Recombiner) par le très grand télescope européen. Ces articles couvrent pratiquement tous les stades de l'évolution stellaire depuis la formation des étoiles et des planètes jusqu'a l'observation de l'explosion de type nova dans un système stellaire évolué. Ces résultats inédits ont été obtenus en utilisant simultanément 3 des 4 télescopes du VLT basés à l'Observatoire européen austral du mont Paranal au Chili. L'instrument AMBER équipant le VLTI (mode interférométrique du VLT) permet dâatteindre une résolution angulaire inégalée de l'ordre du millième de seconde d'angle autorisant l'observation des astres dans différentes longueurs d'onde, dans l'infrarouge proche. Les astronomes obtiennent donc des observations avec une finesse 13 fois plus importante que celle d'un télescope seul. Il devient alors possible de sonder les régions de formation de planètes, d'observer les vents des étoiles en rotation très rapide, d'étudier les différents types de matières éjectées par une étoile massive, de séparer les deux composantes d'une étoile double serrée et de voir en direct l'évolution d'une nova quelques jours seulement après son explosion.

  17. Le médulloblastome chez l'adulte: à propos de 13 cas et revue de la literature

    PubMed Central

    Drissi, Jamal; Affane, Mariam; Elomrani, Abdelhamid; Khouchani, Mouna

    2015-01-01

    Le médulloblastome est une tumeur neuro-ectodermique primitive maligne. Il s'agit d'une tumeur rare chez l'adulte, représentant moins de 1% des tumeurs cérébrales. Nous proposons une étude rétrospective réalisée au sein du service d'Oncologie-Radiothérapie du CHU Mohamed VI de Marrakech sur une période de 13 ans. Le but de notre travail est de déterminer le profil épidémioclinique, thérapeutique, évolutif ainsi que les facteurs pronostiques de cette entité pathologique avec une revue de la littérature. Notre série comportait 13 patients, 10 hommes et 3 femmes, l’âge médian a été 20,8 ans. Le tableau clinique a été révélé par un syndrome d'hypertension intracrânienne (100%), associée à un syndrome cérébelleux (84%). La localisation était hémisphérique (31%) et vermio-hémisphérique (54%). 31% des patients ont bénéficié d'une exérèse chirurgicale totale. 85% des cas avaient une variante classique et 15% une variante desmoplasique. 30% des cas avaient été classés à «risque standard» et 70% à «haut risque». La chirurgie avait été complétée d'une radiothérapie de l'ensemble du névraxe selon la technique de «jonctions mobiles» dans tous les cas. Le délai moyen était de 73 jours. Une chimiothérapie adjuvante avait été réalisée chez 9 cas. Avec un recul moyen de 21.3 mois, l’évolution a été marquée par une récidive tumorale (4 cas), une toxicité auditive (6 cas) et des troubles cognitifs chez un cas. La prise en charge du médulloblastome doit être multidisciplinaire associant neurochirurgiens et oncologues radiothérapeutes. Cette collaboration est le seul garant d'une amélioration de son pronostic. PMID:26889307

  18. Contrôle du marché informel à l’heure de la mondialisation des échanges. Le cas des antirétroviraux au Chili

    PubMed Central

    Brousselle, Astrid; Morales, Cristián

    2013-01-01

    Résumé Les nouveaux médicaments pour le VIH/sida ont créé des besoins d’accessibilité aux traitements que les gouvernements n’ont pas toujours réussi à couvrir. Il en résulte l’émergence d’un marché informel des ARV. Par l’analyse de la situation au Chili, nous traitons des différents créneaux d’approvisionnement, des conséquences de l’existence d’un tel marché, ainsi que des moyens envisageables pour réduire les effets indésirables. Les aspects tant microéconomiques que macroéconomiques concernant le marché et l’accessibilité aux médicaments sont abordés. PMID:23997580

  19. Lele du médecin anesthésiste-réanimateur dans la prise en charge de la femme enceinte porteuse de la maladie de Von Willebrand

    PubMed Central

    Baouahi, Hanane; Zerqouni, Yassine; Doumiri, Mouhcine; Oudghiri, Nezha; Saoud, Anas Tazi

    2015-01-01

    La maladie de Von Willebrand (VWD) est la maladie hémorragique constitutionnelle de l'hémostase la plus fréquente. Elle est liée à un déficit, soit quantitatif, soit qualitatif en facteur willebrand (VWF). Elle se caractérise par son extrême hétérogénéité sur les plans clinique, phénotypique et génotypique. La grossesse et surtout le péri-partum représente une période à risque hémorragique pour ces femmes. Nous rapportons le cas d'une parturiente présentant une maladie de Von Willebrand de type 1 documentée, la difficulté du choix du mode d'accouchement et de la technique anesthésique a été revue. PMID:26977242

  20. Sacroiliites infectieuses dans le centre tunisien: étude rétrospective de 25 cas

    PubMed Central

    Bellazreg, Foued; Alaya, Zeineb; Hattab, Zouhour; Lasfar, Nadia Ben; Ayeche, Mohamed Laziz Ben; Bouajina, Elyes; Letaief, Amel; Hachfi, Wissem

    2016-01-01

    Les sacroiliites infectieuses sont rares mais peuvent se compliquer de séquelles fonctionnelles invalidantes. Décrire les caractéristiques cliniques et bactériologiques des sacroiliites infectieuses chez les patients suivis à Sousse, Centre Tunisien. Etude rétrospective, descriptive, des cas de sacroiliites infectieuses chez les patients hospitalisés à Sousse entre 2000 et 2015. Le diagnostic a été retenu devant des signes cliniques, d'imagerie, et microbiologiques évocateurs. Vingt-cinq patients, 10 hommes et 15 femmes, d’âge moyen 41 ans (19-78) ont été inclus. Les sacroiliites étaient dues à des bactéries pyogènes dans 14 cas (56%), brucelliennes dans 6 cas (24%), et tuberculeuses dans 5 cas (20%). La durée moyenne d’évolution était de 61, 45 et 402 jours respectivement. Les signes cliniques les plus fréquents étaient les douleurs fessières (92%) et la fièvre (88%). La radiographie standard était anormale dans 75% des cas. La TDM et l'IRM sacro-iliaques dans tous les cas. Le diagnostic a été confirmé bactériologiquement dans 24 cas (96%). La durée moyenne d'antibiothérapie était de 83 jours dans les sacroiliites à pyogènes, et de 102 jours dans les SI brucelliennes. L’évolution était favorable chez 12 patients (48%), 9 patients (36%) ont gardé une douleur sacro-iliaque séquellaire, et 4 patients (16%) sont décédés. Dans notre étude, la durée d’évolution de la sacroiliite infectieuse ne permettait pas de prédire la bactérie responsable, d'où la nécessité d'obtenir une documentation bactériologique afin de prescrire une antibiothérapie appropriée. PMID:27583067

  1. [The Le Camus apothecary-grocers in Paris from the XVth to the XVIIth century. Nicolas IV Le Camus owned the Pavillon des Singes in the Rue Saint-Honoré, the residence of the Pocquelin family].

    PubMed

    Warolin, Christian

    2011-02-01

    Five members of the Le Camus family of Paris were apothecary-grocers, a situation passed down from father to son from the end of the reign of Charles VII up to the reign of Louis XIV, in other words for nearly two centuries. Four of them were called Nicolas and the fifth Jehan. Nicolas I practised his trade in the Rue Saint-Antoine; Nicolas II and Jehan lived in the district of Les Halles, on the corner of the Rue Saint-Denis and the Rue de la Chanvrerie. Nicolas IV was a tenant in a house at the crossroads of the Rue Saint-Honoré and the Rue des Poulies, later absorbed by the opening of the Rue du Louvre. In 1638, Nicolas IV bought the house known as "Le Pavillon des Singes" on the corner of the Rue Saint-Honoré and the Rue des Vieilles Etuves (now the Rue Sauval), the home of the family of Jean Pocquelin, father of Jean-Baptiste, the future Molière. When Nicolas IV died, his goods were divided between his son François, lawyer in Parliament, and his daughter Anne who inherited the "Pavillon des Singes". In 1680, she sold it to an administrator of the Hôtel-Dieu. Nicolas IV Le Camus was the last Parisian apothecary of this dynasty and no other Le Camus practised pharmacy in Paris until the Royal Declaration of 25th April 1777 which created the College of Pharmacy and the Master of Pharmacy.

  2. [The Le Camus apothecary-grocers in Paris from the XVth to the XVIIth century. Nicolas IV Le Camus owned the Pavillon des Singes in the Rue Saint-Honoré, the residence of the Pocquelin family].

    PubMed

    Warolin, Christian

    2011-02-01

    Five members of the Le Camus family of Paris were apothecary-grocers, a situation passed down from father to son from the end of the reign of Charles VII up to the reign of Louis XIV, in other words for nearly two centuries. Four of them were called Nicolas and the fifth Jehan. Nicolas I practised his trade in the Rue Saint-Antoine; Nicolas II and Jehan lived in the district of Les Halles, on the corner of the Rue Saint-Denis and the Rue de la Chanvrerie. Nicolas IV was a tenant in a house at the crossroads of the Rue Saint-Honoré and the Rue des Poulies, later absorbed by the opening of the Rue du Louvre. In 1638, Nicolas IV bought the house known as "Le Pavillon des Singes" on the corner of the Rue Saint-Honoré and the Rue des Vieilles Etuves (now the Rue Sauval), the home of the family of Jean Pocquelin, father of Jean-Baptiste, the future Molière. When Nicolas IV died, his goods were divided between his son François, lawyer in Parliament, and his daughter Anne who inherited the "Pavillon des Singes". In 1680, she sold it to an administrator of the Hôtel-Dieu. Nicolas IV Le Camus was the last Parisian apothecary of this dynasty and no other Le Camus practised pharmacy in Paris until the Royal Declaration of 25th April 1777 which created the College of Pharmacy and the Master of Pharmacy. PMID:21661226

  3. Transport adiabatique et phases de Berry : application au contrôle quantique cohérent passif

    NASA Astrophysics Data System (ADS)

    Viennot, D.

    2004-11-01

    L'étude de l'interaction d'atomes ou de molécules avec des champs électromagnétiques intenses, nécéssite le développement de nouveaux outils de modélisation rendant compte de la dynamique quantique de ces systèmes. Une approche purement perturbative étant impossible en champs forts, on s'est tourné vers une approche “adiabatique”. Afin de traiter correctement le cas des croisements de valeurs propres, on a généralisé les formules de transport adiabatique en faisant intervenir une généralisation de la phase de Berry non-abélienne.

  4. Monobloc Le Fort III Distraction Osteogenesis for Correction of Severe Fronto-orbital and Midface Hypoplasia in Pediatric Crouzon Syndrome.

    PubMed

    Hariri, Firdaus; Cheung, Lim Kwong; Rahman, Zainal Ariff Abdul; Mathaneswaran, Vickneswaran; Ganesan, Dharmendra

    2016-01-01

    In severe syndromic craniosynostosis, distraction osteogenesis (DO) provides superior segmental advancement and allows progressive clinical monitoring to ensure that adequate skeletal expansion is achieved. We report two cases of Crouzon syndrome involving a 3-year-old boy and a 4-year-old girl, who were both treated with monobloc Le Fort III DO using a combination of external and internal distraction devices (Synthes, Oberdorf, Switzerland) to treat severe orbital proptosis and obstructed nasopharyngeal airway secondary to severe hypoplastic craniofacial skeletal components. Their skeletal segments were advanced in daily increments by 27 mm and 23 mm, respectively. Results at 18 months postoperatively showed successful outcomes, as evidenced by adequate eye protection, tracheostomy tube decannulation following objective evidence of patent nasopharyngeal airway, and acceptable facial appearance. Monobloc Le Fort III DO using a combination of external and internal devices produces favorable functional and clinical outcomes for the treatment of severe orbital and airway discrepancy in Crouzon syndrome.

  5. Méningite à streptocoque du groupe A chez le nouveau né: à propos d'un cas

    PubMed Central

    El Youssi, Hind; Touaoussa, Aziz; Deham, Hanouf; Yahyaoui, Ghita; Mahmoud, Mustapha

    2015-01-01

    Bien qu'une augmentation de l'incidence et de la sévérité des infections invasives au streptocoque du groupe A (SGA) durant ces dernières décades ait été constatée par plusieurs auteurs, les méningites dues à cette bactérie restent exceptionnelles chez le nouveau né et leur physiopathologie est encore mal connue. A travers ce travail nous allons rapporter le cas d'une méningite néonatale à SGA diagnostiquée au sein de notre formation, avec revue de la littérature s'intéressant à ces méningites. PMID:26185565

  6. Baisse du HDL-cholestérol indicateur du stress oxydatif dans le diabète de type 2

    PubMed Central

    Kabamba, Arsène Tshikongo; Bakari, Salvius Amuri; Longanga, Albert Otshudi; Lukumwena, Zet Kalala

    2014-01-01

    L'hypercholestérolémie est étroitement liée au stress oxydatif. Lorsqu'il y a trop de cholestérol qui circule dans le sang, il n'est pas utilisé en totalité par les cellules et il risque de s'accumuler dans les vaisseaux sanguins. Cela peut entrainer la formation des plaques d'athérosclérose qui gênent la circulation sanguine et provoquent des accidents cardiovasculaires. Le stress oxydatif apparait très tôt dans l'histoire des complications du diabète de type 2, et est lié à l'oxydation du glucose mais aussi à la peroxydation lipidique. Le cholestérol-HDL est un marqueur important du stress oxydatif par sa capacité à faciliter la métabolisation du cholestérol, sa baisse est souvent considérée comme la source de beaucoup d'inquiétudes. L'objectif est l’évaluation de la variation du taux de cholestérol-HDL, marqueur du stress oxydatif, chez les patients diabétiques de type 2 dans la population congolaise. Nous avons inclus dans cette étude prospective des cas témoins des patients diabétiques de type 2 reconnus et diagnostiqués, et des témoins non diabétiques appariés selon l’âge et le sexe. Parallèlement au bilan biologique classique, une analyse d'un des facteurs de risque du stress oxydatif a été réalisée: baisse de HDL-Cholestérol. L’âge moyen des 30 patients diabétiques (47,77±10,78 ans) était comparable à celui des 30 témoins (48,83±10,73 ans). Une baisse significative du cholestérol-HDL dans le sang était observée chez 100% des diabétiques et 50% des témoins (p=0,0000). L'augmentation du HDL cholestérol permet d’éliminer le mauvais cholestérol en excès en nettoyant les tissus et en ramenant le cholestérol vers le foie. Lors du diabète de type 2 on constate une baisse sanguine sensible du taux de HDL-cholestérol, qui est signe indicateur du stress oxydatif. PMID:25767660

  7. Volume Measurements of Laser-generated Pits for In Situ Geochronology using KArLE (Potassium-Argon Laser Experiment)

    NASA Technical Reports Server (NTRS)

    French, R. A.; Cohen, B. A.; Miller, J. S.

    2014-01-01

    The Potassium-Argon Laser Experiment( KArLE), is composed of two main instruments: a spectrometer as part of the Laser-Induced Breakdown Spectroscopy (LIBS) method and a Mass Spectrometer (MS). The LIBS laser ablates a sample and creates a plasma cloud, generating a pit in the sample. The LIBS plasma is measured for K abundance in weight percent and the released gas is measured using the MS, which calculates Ar abundance in mols. To relate the K and Ar measurements, total mass of the ablated sample is needed but can be difficult to directly measure. Instead, density and volume are used to calculate mass, where density is calculated based on the elemental composition of the rock (from the emission spectrum) and volume is determined by pit morphology. This study aims to reduce the uncertainty for KArLE by analyzing pit volume relationships in several analog materials and comparing methods of pit volume measurements and their associated uncertainties.

  8. Simulation du fonctionnement de capteurs solaires à air de type tôle et de type absorbeur poreux

    NASA Astrophysics Data System (ADS)

    Fournier, Michel; Maurissen, Yves

    1993-12-01

    The comparison between air-heated insolators, no porous and porous plate, often has been made experimentaly. The behaviour model of these insolators permit generalization of the study in the conditions where each insolator is the most performant. La comparaison des capteurs solaires à air à absorbeur de type tôle et de type poreux a été abordée le plus souvent de façon expérimentale. La modélisation du fonctionnement de ces types de capteur permet de généraliser cette comparaison et de définir les domaines de fonctionnement où un type de capteur se montre plus efficace que l'autre.

  9. Monobloc Le Fort III Distraction Osteogenesis for Correction of Severe Fronto-orbital and Midface Hypoplasia in Pediatric Crouzon Syndrome.

    PubMed

    Hariri, Firdaus; Cheung, Lim Kwong; Rahman, Zainal Ariff Abdul; Mathaneswaran, Vickneswaran; Ganesan, Dharmendra

    2016-01-01

    In severe syndromic craniosynostosis, distraction osteogenesis (DO) provides superior segmental advancement and allows progressive clinical monitoring to ensure that adequate skeletal expansion is achieved. We report two cases of Crouzon syndrome involving a 3-year-old boy and a 4-year-old girl, who were both treated with monobloc Le Fort III DO using a combination of external and internal distraction devices (Synthes, Oberdorf, Switzerland) to treat severe orbital proptosis and obstructed nasopharyngeal airway secondary to severe hypoplastic craniofacial skeletal components. Their skeletal segments were advanced in daily increments by 27 mm and 23 mm, respectively. Results at 18 months postoperatively showed successful outcomes, as evidenced by adequate eye protection, tracheostomy tube decannulation following objective evidence of patent nasopharyngeal airway, and acceptable facial appearance. Monobloc Le Fort III DO using a combination of external and internal devices produces favorable functional and clinical outcomes for the treatment of severe orbital and airway discrepancy in Crouzon syndrome. PMID:25650655

  10. How Magnets Attract and Repel: Interessement in a Technology Commercialization Competition

    ERIC Educational Resources Information Center

    Spinuzzi, Clay; Nelson, Scott; Thomson, Keela S.; Lorenzini, Francesca; French, Rosemary A.; Pogue, Gregory; London, Noelle

    2016-01-01

    K6015, a South Korean firm seeking to commercialize its magnet technology in the US market, entered a technology commercialization training program structured as a competition. Through this program, K6015 (and others in the program) used several genres to progressively interest different sets of stakeholders. To understand how K6015 applied these…

  11. Discipline and credibility in the post-war australopithecine controversy: Le Gros Clark versus Zuckerman.

    PubMed

    Richmond, Jesse

    2012-01-01

    Paleoanthropologists and outside commentators have often remarked upon the apparent difficulty of securing shared belief among experts in the science of human evolution. The field has been and continues to be particularly prone to disagreement and even controversy among its practitioners to a degree that sets it apart from other areas of scientific inquiry. The fact that the field lies at the intersection of a number of disciplines may help to explain this predicament. Displays of discipline serve as an important resource for scientists as they work to secure credibility. Where a field of inquiry spans a host of disciplinary approaches, there can be disagreement about the kind of disciplined behavior appropriate to making credible claims about that field's subject matter. A conflict of this sort emerged after WW II over the claim that the australopithecines of South Africa represented a likely ancestral link in the evolution of human beings. W. E. Le Gros Clark, working in the established disciplinary tradition of comparative anatomy, endorsed the claim of ancestry, while Solly Zuckerman, reflecting his recent immersion in war-time operations research, criticized that claim on the grounds that it came without the rigorous quantitative demonstration that he felt was the hallmark of a properly disciplined science. PMID:23272594

  12. The Portevin-Le Chatelier Effect in the Ni-Based Superalloy IN100

    NASA Astrophysics Data System (ADS)

    Fernandez-Zelaia, Patxi; Adair, Benjamin S.; Barker, Vincent M.; Antolovich, Stephen D.

    2015-12-01

    The Portevin-Le Chatelier (PLC) effect has been studied in the Ni-based superalloy IN100 which is currently used as a disk material in jet engines. A series of tensile tests was carried out at 588 K, 755 K, and 922 K (315 °C, 482 °C, and 649 °C) at plastic strain rates ranging from a low of 6.21 × 10-6 s-1 to a high of 4.92 × 10-2 s-1. The activation energy was determined using the slope of a line on a strain rate/temperature graph which divided the area of the graph into two regions: (1) "PLC behavior observed," and (2) "No PLC behavior observed." A new statistical approach was developed to objectively differentiate between a true PLC effect and experimental uncertainty ( i.e., "noise"). The value of the activation energy was found to be 1.14 eV/atom, which strongly suggests that the rate controlling process was bulk diffusion of C in the lattice. A qualitative model, based on the Orowan equation and slip band dislocation mechanics, was proposed, which unifies the seemingly disparate ideas of the process being controlled by a single atom/dislocation interaction while at the same time exhibiting significant strains during PLC load drops.

  13. Portevin-Le Chatelier effect under cyclic loading: experimental and numerical investigations

    NASA Astrophysics Data System (ADS)

    Mazière, M.; Pujol d'Andrebo, Q.

    2015-10-01

    The Portevin-Le Chatelier (PLC) effect is generally evidenced by the apparition of serrated yielding under monotonic tensile loading conditions. It appears at room temperature in some aluminium alloys, around ? in some steels and in many other metallic materials. This effect is associated with the propagation of bands of plastic deformation in tensile specimens and can in some cases lead to unexpected failures. The PLC effect has been widely simulated under monotonic conditions using finite elements and an appropriate mechanical model able to reproduce serrations and strain localization. The occurrence of serrations can be predicted using an analytical stability analysis. Recently, this serrated yielding has also been observed in specimens made of Cobalt-based superalloy under cyclic loading, after a large number of cycles. The mechanical model has been identified in this case to accurately reproduce this critical number of cycle where serrations appear. The associated apparition of localized bands of deformation in specimens and their influence on its failure has also been investigated using finite element simulations.

  14. Activation Energy Calculations for the Portevin-Le Chatelier Effect in Nimonic 263 Superalloy

    NASA Astrophysics Data System (ADS)

    Han, G. M.; Tian, C. G.; Chu, Z. K.; Cui, C. Y.; Hu, Z. Q.; Sun, X. F.

    2015-10-01

    The Portevin-Le Chatelier (PLC) effect in the Nimonic 263 superalloy was investigated by tensile test in a wide temperature range, from room temperature to 1033 K (760 °C), and at strain rates between 0.1 and 4 × 10-4 s-1. Types A, B, and C serrations were observed depending upon the test temperatures and strain rates. The activation energy ( Q) for serrated flow was determined by employing various methodologies for T < 723 K (450 °C), where a normal PLC effect was observed. The value of Q was found to be independent of the method employed. The average Q value of 70 KJ/mol was found to be in agreement with that for diffusion of substitutional solutes such as Cr and Mo in a Ni matrix by pipe diffusion. At temperatures ranging from 723 K to 923 K (450 °C to 650 °C), type C serrations and an inverse PLC effect were noticed, which may be caused by unlocking process.

  15. LeRoy Meisinger, Part I: Biographical Tribute with an Assessment of His Contributions to Meteorology.

    NASA Astrophysics Data System (ADS)

    Lewis, John M.

    1995-01-01

    LeRoy Meisinger was a U.S. Weather Bureau meteorologist and aeronaut who worked vigorously to bring meteorology to the aid of aviation in the post-World War 1 period. He was killed at the age of 29 in a scientific ballooning accident that has been detailed in a companion paper by Lewis and Moore. Meisinger's personality and scientific profile are reconstructed by examination of his oeuvre, which contains research contributions augmented by popular articles in the magazines of the period.Meisinger's personal characteristics were those of a quiet, scholarly man with strong interests in science, music, and art. His experiences as a Signal Corps weather officer during World War 1 inclined him toward a career in meteorology. While stationed at the Fort Omaha Balloon School, he became intrigued with the possibilities of using the tree balloon as a platform for tracking air currents.As a research meteorologist with the U.S. Weather Bureau after the war, Meisinger melded adventurous scientific ballooning with the more painstaking and arduous task of scrutinizing data from the limited upper-air network of kite stations. His principal research contribution was a form of differential analysis that extrapolated surface data to the 1- and 2-km levels by using climatological statistics from the upper-air network. The impressive line of research he pioneered at the bureau came to an immediate and abrupt end with his accidental death in 1924.

  16. Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil.

    PubMed

    Lara-Silva, Fabiana de Oliveira; Barata, Ricardo Andrade; Michalsky, Erika Monteiro; Ferreira, Eduardo de Castro; Lopes, Maria Olímpia Garcia; Pinheiro, Aimara da Costa; Fortes-Dias, Consuelo Latorre; Dias, Edelberto Santos

    2014-01-01

    In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Seven different species were represented with 60% of them being Lutzomyia intermedia and Lu. whitmani, both incriminated vectors of ACL. Lu. longipalpis, a proven vector of visceral leishmaniasis (VL) was also captured at high proportion (12.8%). Genomic DNA analysis of 136 species-specific pools of female sand flies followed by molecular genotyping showed the presence of Leishmania infantum DNA in two pools of Lu. longipalpis. The same Leishmania species was found in one blood sample from Rattus norvegicus among 119 blood and tissue samples analysed. This is the first report of Le. infantum in R. norvegicus in the Americas and suggests a possible role for this rodent species in the zoonotic cycle of VL. Our study coincided with the reemergence of VL in Governador Valadares.

  17. A time series study of drug sales and turbidity of tap water in Le Havre, France.

    PubMed

    Beaudeau, Pascal; Le Tertre, Alain; Zeghnoun, Abdelkrim; Zanobetti, Antonella; Schwartz, Joel

    2012-06-01

    The 80,000 inhabitants of the lower part of Le Havre obtain their water supply from two karstic springs, Radicatel and Saint-Laurent. Until 2000, the Radicatel water was settled when turbidity exceeded 3 NTU, then filtered and chlorinated, whereas the Saint-Laurent water was simply chlorinated. Our study aimed to characterize the link between water turbidity and the incidence of acute gastroenteritis (AGE). Records on drug sales used for the treatment of AGE were collected from January 1994 to June 1996 (period 1) and from March 1997 to July 2000 (period 2). Daily counts of drug sales were modeled using a Poisson Regression. We used data set 2 as a discovery set, identifying relevant (i.e. both significant and plausible) exposure covariates and lags. We then tested this model on period 1 as a replication dataset. In period 2, the daily drug sales correlated with finished water turbidity at both resources. Settling substantially modified the risk related to turbidity of both raw and finished waters at Radicatel. Correlations were reproducible in period 1 for water from the Radicatel spring. Timeliness of treatment adaptation to turbidity conditions appears to be crucial for reducing the infectious risk due to karstic waters.

  18. [When medicine appeals to our feelings: Charles de Villers' Le magnétiseur amoureux].

    PubMed

    Moruno, Dolores Martín

    2015-01-01

    This article analyses the representation of affective phenomena brought into play in Charles de Villers' Le magnétiseur amoureux (1787) as it helps to better understand the historical transition from the Galenic conception of the passions of the soul to the cerebral interpretation of emotions. While feelings became the condition of possibility in the occurrence of the therapy, passion is identified as the cause of the young woman's illness, Caroline, who according to the interpretation proposed in this article, suffers from what was identified in the eighteenth century medical tradition as "love melancholy" or "hysteric affection", which were both pathologies that alluded to vapors in order to explain their symptoms. The analysis of the logic of feeling running across Villers' novel impels us to interpret the magnetic fluid in terms of the sympathy created between the two main characters. The ambivalence expressed by Villers between the meaning of "love sentiment" and that of "love passion" allows us to finally understand the somnambulist therapy as erotic knowledge that implies a reflection on love codes in late eighteenth century France. PMID:26403058

  19. Ablation laser femtoseconde pour le dépôt de DLC

    NASA Astrophysics Data System (ADS)

    Loir, A.-S.; Garrelie, F.; Donnet, C.; Goutaland, F.; Belin, M.; Subtil, J.-L.; Le Harzic, R.; Rogemond, F.; Ouerdane, Y.; Laporte, P.

    2003-06-01

    Des films de Diamond-Like Carbon (DLC) ont été déposés, sous vide poussé, par ablation d'une cible de graphite avec un laser Ti : saphir (durée d'impulsion 150 fs, fréquence de répétition 1 kHz, énergie par impulsion 1,5 mJ, longueur d'onde 800 nm) sur substrat standard. Les propriétés de ces couches (structure, adhérence, propriétés nanomécaniques) ont été caractérisées, en fonction des conditions d'élaboration. La caractérisation par spectroscopie Raman de la structure des dépôts obtenus a révélé la présence de diamant nanocristallin au sein d'une matrice amorphe. Le taux d'hybridation sp^3 des couches, déterminé à partir des spectres obtenus par XANES (X-ray Absorption Near Edge Speciroscopy), est voisin de 70 %. Ces différents résultats sont corrélés avec la caractérisation par imagerie résolue en temps du panache plasma créé par ablation laser femtoseconde.

  20. L’infection bactérienne chez le patient brûlé

    PubMed Central

    Le Floch, R.; Naux, E.; Arnould, J.F.

    2015-01-01

    Summary La mort d’un patient brûlé est le plus souvent causée par une infection, bactérienne dans la grande majorité des cas. La perte de la barrière cutanée, les dispositifs invasifs et l’immunodépression liée à la brûlure sont trois mécanismes concourant à la survenue de ces infections. Chez un patient inflammatoire, les signes infectieux généraux d’infection sont peu discriminants. Du fait de la gravité des infections chez ce patient, leur prévention est un paramètre essentiel de la prise en charge. En raison des particularités pharmacocinétiques des brûlés, les posologies d’antibiotiques doivent être adaptés et les dosages sanguins doivent être systématiques. A l’heure où les résistances deviennent préoccupantes, les recherches sur les thérapeutiques sur les alternatives thérapeutiques parmi lesquels les inhibiteurs de facteurs de virulence, les peptides antimicrobiens, les polyphénols, l’immunothérapie…) deviennent cruciales. L’une des possibilités thérapeutiques les plus prometteuses semble être la phagothérapie. PMID:27252607

  1. Unreliable Yet Still Replicable: A Comment on LeBel and Paunonen (2011)

    PubMed Central

    De Schryver, Maarten; Hughes, Sean; Rosseel, Yves; De Houwer, Jan

    2016-01-01

    Lebel and Paunonen (2011) highlight that despite their importance and popularity in both theoretical and applied research, many implicit measures continue to be plagued by a persistent and troublesome issue—low reliability. In their paper, they offer a conceptual analysis of the relationship between reliability, power and replicability, and then provide a series of recommendations for researchers interested in using implicit measures in an experimental setting. At the core of their account is the idea that reliability can be equated with statistical power, such that “lower levels of reliability are associated with decreasing probabilities of detecting a statistically significant effect, given one exists in the population” (p. 573). They also take the additional step of equating reliability and replicability. In our commentary, we draw attention to the fact that there is no direct, fixed or one-to-one relation between reliability and power or replicability. More specifically, we argue that when adopting an experimental (rather than a correlational) approach, researchers strive to minimize inter-individual variation, which has a direct impact on sample based reliability estimates. We evaluate the strengths and weaknesses of the LeBel and Paunonen's recommendations and refine them where appropriate. PMID:26793150

  2. Discipline and credibility in the post-war australopithecine controversy: Le Gros Clark versus Zuckerman.

    PubMed

    Richmond, Jesse

    2012-01-01

    Paleoanthropologists and outside commentators have often remarked upon the apparent difficulty of securing shared belief among experts in the science of human evolution. The field has been and continues to be particularly prone to disagreement and even controversy among its practitioners to a degree that sets it apart from other areas of scientific inquiry. The fact that the field lies at the intersection of a number of disciplines may help to explain this predicament. Displays of discipline serve as an important resource for scientists as they work to secure credibility. Where a field of inquiry spans a host of disciplinary approaches, there can be disagreement about the kind of disciplined behavior appropriate to making credible claims about that field's subject matter. A conflict of this sort emerged after WW II over the claim that the australopithecines of South Africa represented a likely ancestral link in the evolution of human beings. W. E. Le Gros Clark, working in the established disciplinary tradition of comparative anatomy, endorsed the claim of ancestry, while Solly Zuckerman, reflecting his recent immersion in war-time operations research, criticized that claim on the grounds that it came without the rigorous quantitative demonstration that he felt was the hallmark of a properly disciplined science.

  3. The methodology of the Australian Prehospital Outcomes Study of Longitudinal Epidemiology (APOStLE) Project.

    PubMed

    Cone, David C; Irvine, Katrina A; Middleton, Paul M

    2012-01-01

    This paper describes the methodology of a large emergency medical services (EMS) data linkage research project currently under way in the statewide EMS system of New South Wales, Australia. The paper is intended to provide the reader with an understanding of how linkage techniques can be used to facilitate EMS research. This project, the Australian Prehospital Outcomes Study of Longitudinal Epidemiology (APOStLE) Project, links data from six statewide sources (computer-assisted dispatch, EMS patient health care reports, emergency department data, inpatient data, and two death registries) to enable researchers to examine the patient's entire journey through the health care system, from the emergency 0-0-0 call to the emergency department and inpatient setting, through to discharge or death, for approximately 2.6 million patients transported by the Ambulance Service of New South Wales to emergency departments between June 2006 and July 2009. Manual, deterministic, and probabilistic data linkages are described, and potential applications of linked data in EMS research are outlined.

  4. Facial sensibility in adolescents with and without clefts 1 year after undergoing Le Fort I osteotomy.

    PubMed

    Posnick, J C; al-Qattan, M M; Pron, G

    1994-09-01

    Static two-point discrimination, pressure, and vibratory threshold values were measured at standard coordinates in the area corresponding to the infraorbital nerve distribution in 59 adolescents 1 year after undergoing LeFort I osteotomy. The patients were divided into three groups: those born with unilateral cleft lip and palate (n = 30; mean age, 18 years; SD = 2); those with bilateral cleft lip and palate (n = 12; mean age, 19 years; SD = 3); and those without a cleft (n = 17; mean age, 19 years; SD = 3). One year after the osteotomy, none of the patients complained of altered sensibility in the maxillary vestibular mucosa, gingiva, or upper lip and cheek regions. No significant differences were found between the mean postoperative sensibility values of patients with and without clefts, indicating that the presence of clefting did not affect sensory recovery. Mean postoperative static two-point discrimination values were higher than preoperative values in all areas tested and in all patient groups. These results suggest that the sensory recovery, although incomplete, was strong enough to mask any subjective feelings of changes in sensory function.

  5. Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil

    PubMed Central

    Lara-Silva, Fabiana de Oliveira; Michalsky, Érika Monteiro; Ferreira, Eduardo de Castro; Lopes, Maria Olímpia Garcia; Pinheiro, Aimara da Costa; Fortes-Dias, Consuelo Latorre; Dias, Edelberto Santos

    2014-01-01

    In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Seven different species were represented with 60% of them being Lutzomyia intermedia and Lu. whitmani, both incriminated vectors of ACL. Lu. longipalpis, a proven vector of visceral leishmaniasis (VL) was also captured at high proportion (12.8%). Genomic DNA analysis of 136 species-specific pools of female sand flies followed by molecular genotyping showed the presence of Leishmania infantum DNA in two pools of Lu. longipalpis. The same Leishmania species was found in one blood sample from Rattus norvegicus among 119 blood and tissue samples analysed. This is the first report of Le. infantum in R. norvegicus in the Americas and suggests a possible role for this rodent species in the zoonotic cycle of VL. Our study coincided with the reemergence of VL in Governador Valadares. PMID:24707492

  6. ASTROP2-LE: A Mistuned Aeroelastic Analysis System Based on a Two Dimensional Linearized Euler Solver

    NASA Technical Reports Server (NTRS)

    Reddy, T. S. R.; Srivastava, R.; Mehmed, Oral

    2002-01-01

    An aeroelastic analysis system for flutter and forced response analysis of turbomachines based on a two-dimensional linearized unsteady Euler solver has been developed. The ASTROP2 code, an aeroelastic stability analysis program for turbomachinery, was used as a basis for this development. The ASTROP2 code uses strip theory to couple a two dimensional aerodynamic model with a three dimensional structural model. The code was modified to include forced response capability. The formulation was also modified to include aeroelastic analysis with mistuning. A linearized unsteady Euler solver, LINFLX2D is added to model the unsteady aerodynamics in ASTROP2. By calculating the unsteady aerodynamic loads using LINFLX2D, it is possible to include the effects of transonic flow on flutter and forced response in the analysis. The stability is inferred from an eigenvalue analysis. The revised code, ASTROP2-LE for ASTROP2 code using Linearized Euler aerodynamics, is validated by comparing the predictions with those obtained using linear unsteady aerodynamic solutions.

  7. LeRoy Meisinger, Part II: Analysis of the Scientific Ballooning Accident of 2 June 1924.

    NASA Astrophysics Data System (ADS)

    Lewis, John M.; Moore, Charles B.

    1995-02-01

    During the spring of 1924, U.S. Weather Bureau meteorologist LeRoy Meisinger conducted a series of experiments with a free balloon to determine the trajectories of air around extratropical cyclones. The 10th flight in the series ended with a crash of the balloon over central Illinois. Both Meisinger and the pilot, Army Air Services Lt. James Neely, were killed.An effort has been made to reconstruct this accident using information from a review article by early twentieth-century meteorologist Vincent Jakl and newspaper accounts of the accident. The principal results of the study follow.1) Meisinger's balloon was caught in the downdraft of a newly developed thunderstorm over the Bement, Illinois, area on the evening of 2 June;2) a hard landing took place in a cornfield just north of Bement, and loss of ballast at the hard-landing site was sufficient to cause the balloon to rise again; and3) after rebounding from the ground, the balloon with the two aeronauts aboard was struck by lightning. A fire resulted that burned through the netting and led to a crash four miles northeast of the hard-landing site.

  8. Enquête entomologique dans le foyer historique de trypanosomose humaine africaine de Bendjé (Gabon)

    PubMed Central

    Kohagne Tongué, L.; Gounoue Kamkuimo, R.; Mengue M’eyi, P.; Kaba, D.; Louis, F.J.; Mimpfoundi, R.

    2011-01-01

    La situation de la maladie du sommeil est très peu connue au Gabon. De nombreux foyers historiques n’ont pas été prospectés depuis plus de 15 ans. Le foyer historique de Bendjé fournit régulièrement quelques cas, dépistés passivement, qui concernent le plus souvent des pêcheurs dont il est a priori difficile de déterminer le lieu probable de contamination du fait de leur grande mobilité au cours de leurs activités. La présence des hommes infectés dans ce foyer historique pourrait favoriser son réveil s’il existe un contact étroit entre les différents éléments potentiellement présents du cycle épidémiologique (homme, vecteur, trypanosome). Afin de vérifier l’existence éventuelle d’un risque trypanosomien dans ce foyer, nous y avons mené une enquête entomologique. Des pièges ont été posés dans des biotopes fréquentés par l’homme et laissés en place pendant quatre jours. Trois espèces de glossines (Glossina palpalis palpalis, G. pallicera newsteadi et G. caliginea) ont été capturées et deux espèces de trypanosomes (Trypanosoma vivax et T. brucei s.l.) identifiées par PCR. Ces résultats suggèrent l’existence d’un cycle de transmission animal. Le contact entre les hommes et les glossines est particulièrement étroit dans tous les types de site prospectés, à l’exception de la mangrove. PMID:22091460

  9. Étude des modifications structurales de l'eau confinée dans le gel de silice

    NASA Astrophysics Data System (ADS)

    Fouzri, A.; Dorbez-Sridi, R.; Oumezzine, M.

    2004-11-01

    Les modifications structurales de l'eau confinée dans le gel de silice en poudre en fonction du taux d'hydratation sont étudiées par calorimétrie différentielle à balayage et par diffusion des rayons X. L'analyse thermique par DSC a permis de montrer que pour les faibles taux d'hydratation (≤ 50%) l'eau est complètement confinée dans les pores alors que pour les forts taux d'hydratation (>50%) l'eau se trouve aussi bien dans les pores qu'autour des grains de la silice. L'apparition de la glace cubique lors du refroidissement de l'eau confinée dans le gel de silice prouve que l'interaction eau-silice ne peut être négligée lors de la détermination du signal de l'eau. L'extraction du signal, diffusé uniquement par l'eau confinée, à partir des intensités diffusées par le gel de silice à deux taux d'hydratation distincts, révèle dans les fonctions de corrélation de paire un pic à 3.7Å qui ne peut être attribué qu'à une corrélation oxygène-oxygène inexistante dans l'eau massique et résultant de la déformation du réseau tétraédrique des molécules d'eau sous l'effet du confinement et de la proximité d'une surface.

  10. On your mark, get set, GROW! LePRK2-LAT52 interactions regulate pollen tube growth.

    PubMed

    Johnson, Mark A; Preuss, Daphne

    2003-03-01

    Recent discoveries show that LAT52 and LePRK2, two pollen-specific proteins, interact in what might be an autocrine signaling system. This exciting finding indicates that successful fertilization requires ligand-receptor kinase signals that regulate pollen-tube growth. The stage is now set to identify other components of this pathway and to explore their connections with the many signals exchanged between pollen and pistil.

  11. SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.

    PubMed

    Hirata, Kazuyuki; Kotoku, Masayuki; Seki, Noriyoshi; Maeba, Takaki; Maeda, Katsuya; Hirashima, Shintaro; Sakai, Takayuki; Obika, Shingo; Hori, Akimi; Hase, Yasunori; Yamaguchi, Takayuki; Katsuda, Yoshiaki; Hata, Takahiro; Miyagawa, Naoki; Arita, Kojo; Nomura, Yukihiro; Asahina, Kota; Aratsu, Yusuke; Kamada, Masafumi; Adachi, Tsuyoshi; Noguchi, Masato; Doi, Satoki; Crowe, Paul; Bradley, Erin; Steensma, Ruo; Tao, Haiyan; Fenn, Morgan; Babine, Robert; Li, Xiaolin; Thacher, Scott; Hashimoto, Hiromasa; Shiozaki, Makoto

    2016-01-14

    A novel series of RORγ inhibitors was identified starting with the HTS hit 1. After SAR investigation based on a prospective consideration of two drug-likeness metrics, ligand efficiency (LE) and fraction of sp(3) carbon atoms (Fsp(3)), significant improvement of metabolic stability as well as reduction of CYP inhibition was observed, which finally led to discovery of a selective and orally efficacious RORγ inhibitor 3z. PMID:26819660

  12. Le diverticule de l'urètre féminin: à propos de 18 cas

    PubMed Central

    Statoua, Mouad; El Ghanmi, Jihad; Karmouni, Tarik; El Khader, Khalid; Koutani, Abdellatif; Attya, Ahmed Iben

    2014-01-01

    Le diverticule de l'urètre ou poche sous urétrale est une affection rare, d’étiopathogénie non clairement établie, le diagnostique est clinique confirmé par l'urétrocystographie et le traitement est principalement chirurgicale consistant en une diverticulectomie par voie transvaginale. Nous rapportons l'expérience de notre service dans la prise en charge de cette affection en présentons une étude rétrospective sur une durée de 14 ans (entre 2000 et 2014) où on a pris en charge 18 patientes qui présentait un diverticule de l'urètre, l’âge moyen était de 36 ans, une symptomatologie urinaire ramenait les patientes à consulter où le diagnostic de DU a été posé par examen clinique confirmé en précisant ses caractéristiques en urétrocystographie, la prise en charge était chirurgicale et consistait en une diverticulectomie par voie transvaginale. Les suites post-opératoire était simples, la sonde vésicale retirée en moyenne 5,8 jours après l'intervention, on n'a noté aucune complication chez toute nos patientes, hormis un cas de récidives repris. Devant des troubles mictionnels récidivants de la femme, il est indispensable de rechercher un diverticule uréthral à l'examen clinique. La diverticulectomie transvaginale est l'intervention de choix offrant les meilleurs résultats. PMID:25400845

  13. The non-Mendelian inheritance of Lewis-c blood group substance, as demonstrated in the case of a Bombay, Le(a-b-c-) saliva.

    PubMed

    Savvas, R S

    1975-01-01

    A Bombay, Le(a-b-) saliva was shown to lack Pneumococcus type XIV activity, an unusual situation, since this sample should be rich in this precursor to the ABO blood group substances. However, the sample was found to contain a new serological specificity, Le-c. It is argued that simple Mendelian inheritance does not occur with Le-c and single gene control cannot be demonstrated. Failure to repress a fetal gene at birth, as implicated by the similarity in structure between Le-c and carcinoembryonic antigen [SIMMONS and PERLMANN], has been excluded as the mechanism of inheritance of this blood group substance, due to the inability to detect carcinoembryonic antigen in the test saliva.

  14. Le fibromatosis colli ou torticolis congénital: son diagnostic et sa prise en charge à propos de deux cas

    PubMed Central

    Tchaou, Mazamaesso; Pegbessou, Plaodezina Essobozou; Sonhaye, Lantam; Ahouanssou, Patricia Yékpé; Amadou, Abdoulatif; Kolou, Beresa; Kama, Lidi Bessi; Garba, Nouhou Mahamadou; Koussema, Lama Kegdigoma Agoda; N'dakéna, Koffi

    2015-01-01

    Le fibromatosis colli (FC) est pseudotumeur rare du muscle sterno-cléido-mastoïdien (SCM), à l'origine d'un torticolis dit congénital chez le nouveau-né ou le nourrisson. Le mécanisme étio-pathogénique de sa survenue est sujet à controverse. Son diagnostic fait appel à l’échographie qui permet de mettre en évidence un épaississement caractéristique du muscle. Nous rapportons deux cas diagnostiqués par l’échographie avec pour un cas une notion de malposition intra-utérine et pour l'autre cas une absence totale de malposition et de traumatisme obstétrical qui pourtant est évoqué comme élément du mécanisme de survenue du FC. PMID:26834927

  15. Le syndrome des loges du bras: une complication inhabituelle de l'intoxication au monoxyde de carbone

    PubMed Central

    Chkoura, Khalid; Kechna, Hicham; Loutid, Jaouad; Ouzad, Omar; Cherradi, Toufiq; Hachimi, Moulay Ahmed

    2015-01-01

    Le monoxyde de carbone (CO) surnommé “Silent killer” par les Anglo-Saxons représente la première cause de mortalité par intoxication accidentelle ou volontaire en Europe comme aux États-Unis. Au Maroc, le centre anti poison a collecté entre 1991 et 2008, 12976 cas d'intoxication au monoxyde de carbone dont 98,7% étaient accidentelles. Cette intoxication est très exceptionnellement compliquée d'un syndrome de loge qui peut contribuer à une aggravation certaine du pronostic fonctionnel et vital quand il est ignoré ou dominé par d'autres symptômes en particulier neurologiques. Nous rapportons le cas d'un gardien de nuit qui a présenté un syndrome de loge particulier par sa localisation (bras) au cours d'une intoxication au CO qui a évolué favorablement. PMID:26301009

  16. Le système opioïde endogène et l’addiction aux drogues1

    PubMed Central

    Maldonado, Rafael

    2010-01-01

    Résumé L’addiction aux drogues est une maladie psychiatrique chronique qui conduit à d’importantes altérations adaptatives dans les circuits de récompense du cerveau. Plusieurs systèmes de neurotransmission sont impliqués dans ces modifications. Cependant, un des systèmes neurochimiques qui joue un rôle essentiel dans l’addiction est le système opioïde endogène. Les récepteurs opioïdes et les peptides opioïdes endogènes sont très largement présents dans les structures cérébrales qui contrôlent les phénomènes de récompense, en particulier le système mésolimbique. Ces récepteurs et peptides opioïdes participent d’une manière sélective à plusieurs aspects des processus addictifs induits par les opiacés, les cannabinoïdes, les psychostimulants, l’alcool et la nicotine. Cette revue rend compte de l’état actuel des connaissances sur la participation de chaque composante du système opioïde endogène dans les propriétés addictives des différentes drogues. PMID:20176158

  17. Le risque de détresse morale dans la pratique contemporaine des soins de santé.

    PubMed

    Austin, Wendy

    2016-05-01

    Les professionnels de la santé sont des agents moraux dont la relation fiduciaire avec le public est animée par la responsabilité et la promesse de puiser dans leurs connaissances et leurs habiletés pour aider les personnes sous leurs soins. Lorsque leur capacité à tenir cette promesse est freinée ou compromise, ils risquent de souffrir de détresse morale. Le concept de détresse morale est défini et mis en contexte dans le milieu de la santé. Les contraintes et les facteurs qui en sont à l'origine sont présentés, de même que les moyens utilisés par les professionnels de la santé et les organisations de santé pour la soulager. Un changement transformateur s'impose pour vaincre la culture du silence et maintenir un système de santé où il est possible de vivre avec sa conscience. PMID:27068874

  18. Evaluation of Post-operative Complication Rate of Le Fort I Osteotomy: A Retrospective and Prospective Study.

    PubMed

    Garg, Sandeep; Kaur, Supreet

    2014-06-01

    Le Fort I osteotomy has become a routine procedure in elective orthognathic surgery. This procedure is often associated with significant but rare post-operative complications. The study was conducted to evaluate the rate of post-operative complications following conventional Le Fort I osteotomy. Twenty-five healthy adult patients who had to undergo Le Fort I osteotomy without segmentalization of maxilla were included in the study based on indications of surgery. All the patients were followed up for a period of 6 months post-operatively to assess the rate of various post-operative complications such as neurosensory deficit, pulpal sensibility, maxillary sinusitis, vascular complications, aseptic necrosis, unfavourable fractures, ophthalmic complications and instability or non-union of maxilla, etc. The results of our study showed a post-operative complications rate of 4 %. Neurosensory deficit and loss of tooth sensibility were the most common findings during patient evaluation at varying follow-up periods while one patient presented with signs and symptoms of maxillary sinusitis post-operatively. Neurosensory as well as sinusitis recovery took place in almost all the patients within 6 months. It was concluded that thorough understanding of pathophysiological aspects of various complications, careful assessment, treatment planning and the use of proper surgical technique as well as instrumentation may help in further reducing the complication rate.

  19. Is an osteotome necessary for pterygomaxillary dysjunction or dysjunction through the tuberosity during Le Fort I osteotomy? A systematic review.

    PubMed

    Breeze, J; Verea Linares, C; Stockton, P

    2016-04-01

    Pterygomaxillary dysjunction with an osteotome is commonly used to mobilise the maxilla during Le Fort I osteotomy, despite the risk of serious complications. Different instruments and positions have been tried, including dysjunction through the tuberosity. Down fracture by digital pressure alone has also been advocated, but to our knowledge has not been widely adopted. We have therefore reviewed published papers to see if there is any clinical or anatomical evidence for the use of osteotomes to mobilise the maxilla vertically during a Le Fort I osteotomy for either pterygomaxillary dysjunction or dysjunction through the tuberosity. We found only one paper that analysed the anatomy of the pterygomaxillary fissure and described small bony bridges and syncondroses across the joint. We found no clinical or anatomical evidence for the use of osteotomes in pterygomaxillary separation or separation through the tuberosity. A large clinical trial on down fracture of the maxilla by digital pressure alone showed no serious complications, and we found no strong evidence to justify the use of osteotomes in pterygomaxillary dysjunction or dysjunction through the tuberosity. We have successfully used digital pressure alone in 138 consecutive Le Fort I osteotomies, and we encourage our colleagues to consider adopting this approach.

  20. Accuracy and reliability of linear measurements using 3-dimensional computed tomographic imaging software for Le Fort I Osteotomy.

    PubMed

    Gaia, Bruno Felipe; Pinheiro, Lucas Rodrigues; Umetsubo, Otávio Shoite; Santos, Oseas; Costa, Felipe Ferreira; Cavalcanti, Marcelo Gusmão Paraíso

    2014-03-01

    Our purpose was to compare the accuracy and reliability of linear measurements for Le Fort I osteotomy using volume rendering software. We studied 11 dried skulls and used cone-beam computed tomography (CT) to generate 3-dimensional images. Linear measurements were based on craniometric anatomical landmarks that were predefined as specifically used for Le Fort I osteotomy, and identified twice each by 2 radiologists, independently, using Dolphin imaging version 11.5.04.35. A third examiner then made physical measurements using digital calipers. There was a significant difference between Dolphin imaging and the gold standard, particularly in the pterygoid process. The largest difference was 1.85mm (LLpPtg L). The mean differences between the physical and the 3-dimensional linear measurements ranged from -0.01 to 1.12mm for examiner 1, and 0 to 1.85mm for examiner 2. Interexaminer analysis ranged from 0.51 to 0.93. Intraexaminer correlation coefficients ranged from 0.81 to 0.96 and 0.57 to 0.92, for examiners 1 and 2, respectively. We conclude that the Dolphin imaging should be used sparingly during Le Fort I osteotomy.