Sample records for interesting parameter range

  1. Optimization Under Uncertainty for Electronics Cooling Design

    NASA Astrophysics Data System (ADS)

    Bodla, Karthik K.; Murthy, Jayathi Y.; Garimella, Suresh V.

    Optimization under uncertainty is a powerful methodology used in design and optimization to produce robust, reliable designs. Such an optimization methodology, employed when the input quantities of interest are uncertain, produces output uncertainties, helping the designer choose input parameters that would result in satisfactory thermal solutions. Apart from providing basic statistical information such as mean and standard deviation in the output quantities, auxiliary data from an uncertainty based optimization, such as local and global sensitivities, help the designer decide the input parameter(s) to which the output quantity of interest is most sensitive. This helps the design of experiments based on the most sensitive input parameter(s). A further crucial output of such a methodology is the solution to the inverse problem - finding the allowable uncertainty range in the input parameter(s), given an acceptable uncertainty range in the output quantity of interest...

  2. Wall Shear Stress Distribution in a Patient-Specific Cerebral Aneurysm Model using Reduced Order Modeling

    NASA Astrophysics Data System (ADS)

    Han, Suyue; Chang, Gary Han; Schirmer, Clemens; Modarres-Sadeghi, Yahya

    2016-11-01

    We construct a reduced-order model (ROM) to study the Wall Shear Stress (WSS) distributions in image-based patient-specific aneurysms models. The magnitude of WSS has been shown to be a critical factor in growth and rupture of human aneurysms. We start the process by running a training case using Computational Fluid Dynamics (CFD) simulation with time-varying flow parameters, such that these parameters cover the range of parameters of interest. The method of snapshot Proper Orthogonal Decomposition (POD) is utilized to construct the reduced-order bases using the training CFD simulation. The resulting ROM enables us to study the flow patterns and the WSS distributions over a range of system parameters computationally very efficiently with a relatively small number of modes. This enables comprehensive analysis of the model system across a range of physiological conditions without the need to re-compute the simulation for small changes in the system parameters.

  3. Modified screening interaction potential on dust lattice waves in dusty plasma ring

    NASA Astrophysics Data System (ADS)

    He, Kerong; Chen, Hui; Liu, Sanqiu

    2017-05-01

    In the present paper, the modified screening interaction potential was adopted to investigate the dust lattice waves in dusty ring. Firstly, the influence of parameter ε on the modified screening interaction potential was analyzed; and it was found that the parameter ε has a long-range effect on the pairwise interaction between the particles. Secondly, the dispersion relations of longitudinal and transverse waves are obtained, and the effect of long-range action parameter ε, dimensionless lattice parameter α and dimensionless shielding parameter \\tilde{κ } on the dust lattice waves propagation in dusty ring are studied. Some interesting phenomena, such as the coupling of longitudinal and transverse waves, and instabilities of transverse waves are found, which are in good agreement with some previous works. Finally, the transverse wave instabilities and the relevant critical lattice parameter αc are presented and discussed.

  4. An Extreme-Value Approach to Anomaly Vulnerability Identification

    NASA Technical Reports Server (NTRS)

    Everett, Chris; Maggio, Gaspare; Groen, Frank

    2010-01-01

    The objective of this paper is to present a method for importance analysis in parametric probabilistic modeling where the result of interest is the identification of potential engineering vulnerabilities associated with postulated anomalies in system behavior. In the context of Accident Precursor Analysis (APA), under which this method has been developed, these vulnerabilities, designated as anomaly vulnerabilities, are conditions that produce high risk in the presence of anomalous system behavior. The method defines a parameter-specific Parameter Vulnerability Importance measure (PVI), which identifies anomaly risk-model parameter values that indicate the potential presence of anomaly vulnerabilities, and allows them to be prioritized for further investigation. This entails analyzing each uncertain risk-model parameter over its credible range of values to determine where it produces the maximum risk. A parameter that produces high system risk for a particular range of values suggests that the system is vulnerable to the modeled anomalous conditions, if indeed the true parameter value lies in that range. Thus, PVI analysis provides a means of identifying and prioritizing anomaly-related engineering issues that at the very least warrant improved understanding to reduce uncertainty, such that true vulnerabilities may be identified and proper corrective actions taken.

  5. Electrical transport via variable range hopping in an individual multi-wall carbon nanotube

    NASA Astrophysics Data System (ADS)

    Husain Khan, Zishan; Husain, M.; Perng, T. P.; Salah, Numan; Habib, Sami

    2008-11-01

    E-beam lithography is used to make four leads on an individual multi-wall carbon nanotube for carrying out electrical transport measurements. Temperature dependence of conductance of an individual multi-wall carbon nanotube (MWNT) is studied over a temperature range of (297 4.8 K). The results indicate that the conduction is governed by variable range hopping (VRH) for the entire temperature range (297 4.8 K). This VRH mechanism changes from three dimensions (3D) to two dimensions (2D) as we go down to 70 K. Three-dimensional variable range hopping (3D VRH) is responsible for conduction in the temperature range (297 70 K), which changes to two-dimensional VRH for much lower temperatures (70 4.8 K). For 3D VRH, various Mott parameters such as density of states, hopping distance and hopping energy have been calculated. The 2D VRH mechanism has been applied for the temperature range (70 4.8 K) and, with the help of this model, the parameters such as localization length and hopping distance are calculated. All these parameters give interesting information about this complex structure, which may be useful for many applications.

  6. PERSEUS QC: preparing statistic data sets

    NASA Astrophysics Data System (ADS)

    Belokopytov, Vladimir; Khaliulin, Alexey; Ingerov, Andrey; Zhuk, Elena; Gertman, Isaac; Zodiatis, George; Nikolaidis, Marios; Nikolaidis, Andreas; Stylianou, Stavros

    2017-09-01

    The Desktop Oceanographic Data Processing Module was developed for visual analysis of interdisciplinary cruise measurements. The program provides the possibility of data selection based on different criteria, map plotting, sea horizontal sections, and sea depth vertical profiles. The data selection in the area of interest can be specified according to a set of different physical and chemical parameters complimented by additional parameters, such as the cruise number, ship name, and time period. The visual analysis of a set of vertical profiles in the selected area allows to determine the quality of the data, their location and the time of the in-situ measurements and to exclude any questionable data from the statistical analysis. For each selected set of profiles, the average vertical profile, the minimal and maximal values of the parameter under examination and the root mean square (r.m.s.) are estimated. These estimates are compared with the parameter ranges, set for each sub-region by MEDAR/MEDATLAS-II and SeaDataNet2 projects. In the framework of the PERSEUS project, certain parameters which lacked a range were calculated from scratch, while some of the previously used ranges were re-defined using more comprehensive data sets based on SeaDataNet2, SESAME and PERSEUS projects. In some cases we have used additional sub- regions to redefine the ranges ore precisely. The recalculated ranges are used to improve the PERSEUS Data Quality Control.

  7. Detection of the spatial accuracy of an O-arm in the region of surgical interest

    NASA Astrophysics Data System (ADS)

    Koivukangas, Tapani; Katisko, Jani P. A.; Koivukangsa, John P.

    2013-03-01

    Medical imaging is an essential component of a wide range of surgical procedures1. For image guided surgical (IGS) procedures, medical images are the main source of information2. The IGS procedures rely largely on obtained image data, so the data needs to provide differentiation between normal and abnormal tissues, especially when other surgical guidance devices are used in the procedures. The image data also needs to provide accurate spatial representation of the patient3. This research has concentrated on the concept of accuracy assessment of IGS devices to meet the needs of quality assurance in the hospital environment. For this purpose, two precision engineered accuracy assessment phantoms have been developed as advanced materials and methods for the community. The phantoms were designed to mimic the volume of a human head as the common region of surgical interest (ROSI). This paper introduces the utilization of the phantoms in spatial accuracy assessment of a commercial surgical 3D CT scanner, the O-Arm. The study presents methods and results of image quality detection of possible geometrical distortions in the region of surgical interest. The results show that in the pre-determined ROSI there are clear image distortion and artefacts using too high imaging parameters when scanning the objects. On the other hand, when using optimal parameters, the O-Arm causes minimal error in IGS accuracy. The detected spatial inaccuracy of the O-Arm with used parameters was in the range of less than 1.00 mm.

  8. Data collection and simulation of high range resolution laser radar for surface mine detection

    NASA Astrophysics Data System (ADS)

    Steinvall, Ove; Chevalier, Tomas; Larsson, Håkan

    2006-05-01

    Rapid and efficient detection of surface mines, IED's (Improvised Explosive Devices) and UXO (Unexploded Ordnance) is of high priority in military conflicts. High range resolution laser radars combined with passive hyper/multispectral sensors offer an interesting concept to help solving this problem. This paper reports on laser radar data collection of various surface mines in different types of terrain. In order to evaluate the capability of 3D imaging for detecting and classifying the objects of interest a scanning laser radar was used to scan mines and surrounding terrain with high angular and range resolution. These data were then fed into a laser radar model capable of generating range waveforms for a variety of system parameters and combinations of different targets and backgrounds. We can thus simulate a potential system by down sampling to relevant pixel sizes and laser/receiver characteristics. Data, simulations and examples will be presented.

  9. Data Aggregation, Curation and Modeling Approaches to Deliver Prediction Models to Support Computational Toxicology at the EPA (ACS Fall meeting)

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program develops and utilizes QSAR modeling approaches across a broad range of applications. In terms of physical chemistry we have a particular interest in the prediction of basic physicochemical parameters ...

  10. Phase diagram of the Shastry-Sutherland Kondo lattice model with classical localized spins: a variational calculation study

    NASA Astrophysics Data System (ADS)

    Shahzad, Munir; Sengupta, Pinaki

    2017-08-01

    We study the Shastry-Sutherland Kondo lattice model with additional Dzyaloshinskii-Moriya (DM) interactions, exploring the possible magnetic phases in its multi-dimensional parameter space. Treating the local moments as classical spins and using a variational ansatz, we identify the parameter ranges over which various common magnetic orderings are potentially stabilized. Our results reveal that the competing interactions result in a heightened susceptibility towards a wide range of spin configurations including longitudinal ferromagnetic and antiferromagnetic order, coplanar flux configurations and most interestingly, multiple non-coplanar configurations including a novel canted-flux state as the different Hamiltonian parameters like electron density, interaction strengths and degree of frustration are varied. The non-coplanar and non-collinear magnetic ordering of localized spins behave like emergent electromagnetic fields and drive unusual transport and electronic phenomena.

  11. Nonlinear unstable viscous fingers in Hele--Shaw flows. I. Experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kopf-Sill, A.R.; Homsy, G.M.

    1988-02-01

    Post-instability viscous fingering in rectilinear flow in a Hele--Shaw cell has been studied experimentally. Of particular interest was the characterization of the range of length scales associated with tip splitting, over a reasonably wide range of parameters. A digital imaging system was used to record the patterns as a function of time, which allowed properties such as the tip velocity, finger width, perimeter, and area to be studied as functions of time and capillary number. The tip velocity was observed to be approximately constant regardless of the occurrence of splitting events, and the average finger width decreased as the degreemore » of supercriticality increased. Quantitative measures of the fact that there is a limit to the complexity of viscous fingers are provided, and that over the range of parameters studied, no evidence for fractal fingering exists. A discussion of the dynamics of tip splitting explains why this is so.« less

  12. Compartmental analysis and its manifold applications to pharmacokinetics.

    PubMed

    Rescigno, Aldo

    2010-03-01

    In this paper, I show how the concept of compartment evolved from the simple dilution of a substance in a physiological volume to its distribution in a network of interconnected spaces. The differential equations describing the fate of a substance in a living being can be solved, qualitatively and quantitatively, with the help of a number of mathematical techniques. A number of parameters of pharmacokinetic interest can be computed from the experimental data; often, the data available are not sufficient to determine some parameters, but it is possible to determine their range.

  13. A study of the origin of large magnetic field coupled electric polarization in HoAl(BO3)4

    NASA Astrophysics Data System (ADS)

    Yu, Tian; Zhang, Han; Tyson, Trevor; Chen, Zhiqiang; Abeykoon, Milinda; Nelson, Christie; Bezmaternykh, Leonard

    2015-03-01

    The multiferroic system RAl(BO3)4 is known to exhibit a strong coupling of magnetic field to the electrical polarization. Recently a giant magnetoelectric effect was found in HoAl3(BO3)4 system. This phenomenon is considered quite interesting because the value discovered is significantly higher than reported values of linear magnetoelectric or even multiferroic compounds. We are conducting detailed structural measurements to understand the coupling. We are exploring the local and long range structure in these systems using x-ray PDF, XAFS and single crystal diffraction measurement between 10 K and 400 K. Structural parameters including lattice parameters and ADPs are being determined over the full temperature range. This work is supported by DOE Grant DE-FG02-07ER46402.

  14. Modeling of a Ne/Xe dielectric barrier discharge excilamp for improvement of VUV radiation production

    NASA Astrophysics Data System (ADS)

    Khodja, K.; Belasri, A.; Loukil, H.

    2017-08-01

    This work is devoted to excimer lamp efficiency optimization by using a homogenous discharge model of a dielectric barrier discharge in a Ne-Xe mixture. The model includes the plasma chemistry, electrical circuit, and Boltzmann equation. In this paper, we are particularly interested in the electrical and kinetic properties and light output generated by the DBD. Xenon is chosen for its high luminescence in the range of vacuum UV radiation around 173 nm. Our study is motivated by interest in this type of discharge in many industrial applications, including the achievement of high light output lamps. In this work, we used an applied sinusoidal voltage, frequency, gas pressure, and concentration in the ranges of 2-8 kV, 10-200 kHz, 100-800 Torr, and 10-50%, respectively. The analyzed results concern the voltage V p across the gap, the dielectric voltage V d, the discharge current I, and the particles densities. We also investigated the effect of the electric parameters and xenon concentration on the lamp efficiency. This investigation will allow one to find out the appropriate parameters for Ne/Xe DBD excilamps to improve their efficiency.

  15. Low-frequency sound propagation modeling over a locally-reacting boundary using the parabolic approximation

    NASA Technical Reports Server (NTRS)

    Robertson, J. S.; Siegman, W. L.; Jacobson, M. J.

    1989-01-01

    There is substantial interest in the analytical and numerical modeling of low-frequency, long-range atmospheric acoustic propagation. Ray-based models, because of frequency limitations, do not always give an adequate prediction of quantities such as sound pressure or intensity levels. However, the parabolic approximation method, widely used in ocean acoustics, and often more accurate than ray models for lower frequencies of interest, can be applied to acoustic propagation in the atmosphere. Modifications of an existing implicit finite-difference implementation for computing solutions to the parabolic approximation are discussed. A locally-reacting boundary is used together with a one-parameter impedance model. Intensity calculations are performed for a number of flow resistivity values in both quiescent and windy atmospheres. Variations in the value of this parameter are shown to have substantial effects on the spatial variation of the acoustic signal.

  16. Photon Interaction Parameters for Some Borate Glasses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mann, Nisha; Kaur, Updesh; Singh, Tejbir

    2010-11-06

    Some photon interaction parameters of dosimetric interest such as mass attenuation coefficients, effective atomic number, electron density and KERMA relative to air have been computed in the wide energy range from 1 keV to 100 GeV for some borate glasses viz. barium-lead borate, bismuth-borate, calcium-strontium borate, lead borate and zinc-borate glass. It has been observed that lead borate glass and barium-lead borate glass have maximum values of mass attenuation coefficient, effective atomic number and KERMA relative to air. Hence, these borate glasses are suitable as gamma ray shielding material, packing of radioactive sources etc.

  17. Entropy corrected holographic dark energy models in modified gravity

    NASA Astrophysics Data System (ADS)

    Jawad, Abdul; Azhar, Nadeem; Rani, Shamaila

    We consider the power law and the entropy corrected holographic dark energy (HDE) models with Hubble horizon in the dynamical Chern-Simons modified gravity. We explore various cosmological parameters and planes in this framework. The Hubble parameter lies within the consistent range at the present and later epoch for both entropy corrected models. The deceleration parameter explains the accelerated expansion of the universe. The equation of state (EoS) parameter corresponds to quintessence and cold dark matter (ΛCDM) limit. The ωΛ-ωΛ‧ approaches to ΛCDM limit and freezing region in both entropy corrected models. The statefinder parameters are consistent with ΛCDM limit and dark energy (DE) models. The generalized second law of thermodynamics remain valid in all cases of interacting parameter. It is interesting to mention here that our results of Hubble, EoS parameter and ωΛ-ωΛ‧ plane show consistency with the present observations like Planck, WP, BAO, H0, SNLS and nine-year WMAP.

  18. Sensitivity regularization of the Cramér-Rao lower bound to minimize B1 nonuniformity effects in quantitative magnetization transfer imaging.

    PubMed

    Boudreau, Mathieu; Pike, G Bruce

    2018-05-07

    To develop and validate a regularization approach of optimizing B 1 insensitivity of the quantitative magnetization transfer (qMT) pool-size ratio (F). An expression describing the impact of B 1 inaccuracies on qMT fitting parameters was derived using a sensitivity analysis. To simultaneously optimize for robustness against noise and B 1 inaccuracies, the optimization condition was defined as the Cramér-Rao lower bound (CRLB) regularized by the B 1 -sensitivity expression for the parameter of interest (F). The qMT protocols were iteratively optimized from an initial search space, with and without B 1 regularization. Three 10-point qMT protocols (Uniform, CRLB, CRLB+B 1 regularization) were compared using Monte Carlo simulations for a wide range of conditions (e.g., SNR, B 1 inaccuracies, tissues). The B 1 -regularized CRLB optimization protocol resulted in the best robustness of F against B 1 errors, for a wide range of SNR and for both white matter and gray matter tissues. For SNR = 100, this protocol resulted in errors of less than 1% in mean F values for B 1 errors ranging between -10 and 20%, the range of B 1 values typically observed in vivo in the human head at field strengths of 3 T and less. Both CRLB-optimized protocols resulted in the lowest σ F values for all SNRs and did not increase in the presence of B 1 inaccuracies. This work demonstrates a regularized optimization approach for improving the robustness of auxiliary measurements (e.g., B 1 ) sensitivity of qMT parameters, particularly the pool-size ratio (F). Predicting substantially less B 1 sensitivity using protocols optimized with this method, B 1 mapping could even be omitted for qMT studies primarily interested in F. © 2018 International Society for Magnetic Resonance in Medicine.

  19. A Preliminary Bayesian Analysis of Incomplete Longitudinal Data from a Small Sample: Methodological Advances in an International Comparative Study of Educational Inequality

    ERIC Educational Resources Information Center

    Hsieh, Chueh-An; Maier, Kimberly S.

    2009-01-01

    The capacity of Bayesian methods in estimating complex statistical models is undeniable. Bayesian data analysis is seen as having a range of advantages, such as an intuitive probabilistic interpretation of the parameters of interest, the efficient incorporation of prior information to empirical data analysis, model averaging and model selection.…

  20. Time delay and long-range connection induced synchronization transitions in Newman-Watts small-world neuronal networks.

    PubMed

    Qian, Yu

    2014-01-01

    The synchronization transitions in Newman-Watts small-world neuronal networks (SWNNs) induced by time delay τ and long-range connection (LRC) probability P have been investigated by synchronization parameter and space-time plots. Four distinct parameter regions, that is, asynchronous region, transition region, synchronous region, and oscillatory region have been discovered at certain LRC probability P = 1.0 as time delay is increased. Interestingly, desynchronization is observed in oscillatory region. More importantly, we consider the spatiotemporal patterns obtained in delayed Newman-Watts SWNNs are the competition results between long-range drivings (LRDs) and neighboring interactions. In addition, for moderate time delay, the synchronization of neuronal network can be enhanced remarkably by increasing LRC probability. Furthermore, lag synchronization has been found between weak synchronization and complete synchronization as LRC probability P is a little less than 1.0. Finally, the two necessary conditions, moderate time delay and large numbers of LRCs, are exposed explicitly for synchronization in delayed Newman-Watts SWNNs.

  1. Time Delay and Long-Range Connection Induced Synchronization Transitions in Newman-Watts Small-World Neuronal Networks

    PubMed Central

    Qian, Yu

    2014-01-01

    The synchronization transitions in Newman-Watts small-world neuronal networks (SWNNs) induced by time delay and long-range connection (LRC) probability have been investigated by synchronization parameter and space-time plots. Four distinct parameter regions, that is, asynchronous region, transition region, synchronous region, and oscillatory region have been discovered at certain LRC probability as time delay is increased. Interestingly, desynchronization is observed in oscillatory region. More importantly, we consider the spatiotemporal patterns obtained in delayed Newman-Watts SWNNs are the competition results between long-range drivings (LRDs) and neighboring interactions. In addition, for moderate time delay, the synchronization of neuronal network can be enhanced remarkably by increasing LRC probability. Furthermore, lag synchronization has been found between weak synchronization and complete synchronization as LRC probability is a little less than 1.0. Finally, the two necessary conditions, moderate time delay and large numbers of LRCs, are exposed explicitly for synchronization in delayed Newman-Watts SWNNs. PMID:24810595

  2. Density-dependent home-range size revealed by spatially explicit capture–recapture

    USGS Publications Warehouse

    Efford, M.G.; Dawson, Deanna K.; Jhala, Y.V.; Qureshi, Q.

    2016-01-01

    The size of animal home ranges often varies inversely with population density among populations of a species. This fact has implications for population monitoring using spatially explicit capture–recapture (SECR) models, in which both the scale of home-range movements σ and population density D usually appear as parameters, and both may vary among populations. It will often be appropriate to model a structural relationship between population-specific values of these parameters, rather than to assume independence. We suggest re-parameterizing the SECR model using kp = σp √Dp, where kp relates to the degree of overlap between home ranges and the subscript p distinguishes populations. We observe that kp is often nearly constant for populations spanning a range of densities. This justifies fitting a model in which the separate kp are replaced by the single parameter k and σp is a density-dependent derived parameter. Continuous density-dependent spatial variation in σ may also be modelled, using a scaled non-Euclidean distance between detectors and the locations of animals. We illustrate these methods with data from automatic photography of tigers (Panthera tigris) across India, in which the variation is among populations, from mist-netting of ovenbirds (Seiurus aurocapilla) in Maryland, USA, in which the variation is within a single population over time, and from live-trapping of brushtail possums (Trichosurus vulpecula) in New Zealand, modelling spatial variation within one population. Possible applications and limitations of the methods are discussed. A model in which kp is constant, while density varies, provides a parsimonious null model for SECR. The parameter k of the null model is a concise summary of the empirical relationship between home-range size and density that is useful in comparative studies. We expect deviations from this model, particularly the dependence of kp on covariates, to be biologically interesting.

  3. Challenges of model transferability to data-scarce regions (Invited)

    NASA Astrophysics Data System (ADS)

    Samaniego, L. E.

    2013-12-01

    Developing the ability to globally predict the movement of water on the land surface at spatial scales from 1 to 5 km constitute one of grand challenges in land surface modelling. Copying with this grand challenge implies that land surface models (LSM) should be able to make reliable predictions across locations and/or scales other than those used for parameter estimation. In addition to that, data scarcity and quality impose further difficulties in attaining reliable predictions of water and energy fluxes at the scales of interest. Current computational limitations impose also seriously limitations to exhaustively investigate the parameter space of LSM over large domains (e.g. greater than half a million square kilometers). Addressing these challenges require holistic approaches that integrate the best techniques available for parameter estimation, field measurements and remotely sensed data at their native resolutions. An attempt to systematically address these issues is the multiscale parameterisation technique (MPR) that links high resolution land surface characteristics with effective model parameters. This technique requires a number of pedo-transfer functions and a much fewer global parameters (i.e. coefficients) to be inferred by calibration in gauged basins. The key advantage of this technique is the quasi-scale independence of the global parameters which enables to estimate global parameters at coarser spatial resolutions and then to transfer them to (ungauged) areas and scales of interest. In this study we show the ability of this technique to reproduce the observed water fluxes and states over a wide range of climate and land surface conditions ranging from humid to semiarid and from sparse to dense forested regions. Results of transferability of global model parameters in space (from humid to semi-arid basins) and across scales (from coarser to finer) clearly indicate the robustness of this technique. Simulations with coarse data sets (e.g. EOBS forcing 25x25 km2, FAO soil map 1:5000000) using parameters obtained with high resolution information (REGNIE forcing 1x1 km2, BUEK soil map 1:1000000) in different climatic regions indicate the potential of MPR for prediction in data-scarce regions. In this presentation, we will also discuss how the transferability of global model parameters across scales and locations helps to identify deficiencies in model structure and regionalization functions.

  4. A pharmacometric case study regarding the sensitivity of structural model parameter estimation to error in patient reported dosing times.

    PubMed

    Knights, Jonathan; Rohatagi, Shashank

    2015-12-01

    Although there is a body of literature focused on minimizing the effect of dosing inaccuracies on pharmacokinetic (PK) parameter estimation, most of the work centers on missing doses. No attempt has been made to specifically characterize the effect of error in reported dosing times. Additionally, existing work has largely dealt with cases in which the compound of interest is dosed at an interval no less than its terminal half-life. This work provides a case study investigating how error in patient reported dosing times might affect the accuracy of structural model parameter estimation under sparse sampling conditions when the dosing interval is less than the terminal half-life of the compound, and the underlying kinetics are monoexponential. Additional effects due to noncompliance with dosing events are not explored and it is assumed that the structural model and reasonable initial estimates of the model parameters are known. Under the conditions of our simulations, with structural model CV % ranging from ~20 to 60 %, parameter estimation inaccuracy derived from error in reported dosing times was largely controlled around 10 % on average. Given that no observed dosing was included in the design and sparse sampling was utilized, we believe these error results represent a practical ceiling given the variability and parameter estimates for the one-compartment model. The findings suggest additional investigations may be of interest and are noteworthy given the inability of current PK software platforms to accommodate error in dosing times.

  5. Is the sky the limit? On the expansion threshold of a species' range.

    PubMed

    Polechová, Jitka

    2018-06-15

    More than 100 years after Grigg's influential analysis of species' borders, the causes of limits to species' ranges still represent a puzzle that has never been understood with clarity. The topic has become especially important recently as many scientists have become interested in the potential for species' ranges to shift in response to climate change-and yet nearly all of those studies fail to recognise or incorporate evolutionary genetics in a way that relates to theoretical developments. I show that range margins can be understood based on just two measurable parameters: (i) the fitness cost of dispersal-a measure of environmental heterogeneity-and (ii) the strength of genetic drift, which reduces genetic diversity. Together, these two parameters define an 'expansion threshold': adaptation fails when genetic drift reduces genetic diversity below that required for adaptation to a heterogeneous environment. When the key parameters drop below this expansion threshold locally, a sharp range margin forms. When they drop below this threshold throughout the species' range, adaptation collapses everywhere, resulting in either extinction or formation of a fragmented metapopulation. Because the effects of dispersal differ fundamentally with dimension, the second parameter-the strength of genetic drift-is qualitatively different compared to a linear habitat. In two-dimensional habitats, genetic drift becomes effectively independent of selection. It decreases with 'neighbourhood size'-the number of individuals accessible by dispersal within one generation. Moreover, in contrast to earlier predictions, which neglected evolution of genetic variance and/or stochasticity in two dimensions, dispersal into small marginal populations aids adaptation. This is because the reduction of both genetic and demographic stochasticity has a stronger effect than the cost of dispersal through increased maladaptation. The expansion threshold thus provides a novel, theoretically justified, and testable prediction for formation of the range margin and collapse of the species' range.

  6. Characterizing Uncertainty In Electrical Resistivity Tomography Images Due To Subzero Temperature Variability

    NASA Astrophysics Data System (ADS)

    Herring, T.; Cey, E. E.; Pidlisecky, A.

    2017-12-01

    Time-lapse electrical resistivity tomography (ERT) is used to image changes in subsurface electrical conductivity (EC), e.g. due to a saline contaminant plume. Temperature variation also produces an EC response, which interferes with the signal of interest. Temperature compensation requires the temperature distribution and the relationship between EC and temperature, but this relationship at subzero temperatures is not well defined. The goal of this study is to examine how uncertainty in the subzero EC/temperature relationship manifests in temperature corrected ERT images, especially with respect to relevant plume parameters (location, contaminant mass, etc.). First, a lab experiment was performed to determine the EC of fine-grained glass beads over a range of temperatures (-20° to 20° C) and saturations. The measured EC/temperature relationship was then used to add temperature effects to a hypothetical EC model of a conductive plume. Forward simulations yielded synthetic field data to which temperature corrections were applied. Varying the temperature/EC relationship used in the temperature correction and comparing the temperature corrected ERT results to the synthetic model enabled a quantitative analysis of the error of plume parameters associated with temperature variability. Modeling possible scenarios in this way helps to establish the feasibility of different time-lapse ERT applications by quantifying the uncertainty associated with parameter(s) of interest.

  7. Radiophysical methods of diagnostics the Earth's ionosphere and the underlying earth's surface by remote sensing in the short-wave range of radio waves

    NASA Astrophysics Data System (ADS)

    Belov, S. Yu.; Belova, I. N.

    2017-11-01

    Monitoring of the earth's surface by remote sensing in the short-wave band can provide quick identification of some characteristics of natural systems. This band range allows one to diagnose subsurface aspects of the earth, as the scattering parameter is affected by irregularities in the dielectric permittivity of subsurface structures. This method based on the organization of the monitoring probe may detect changes in these environments, for example, to assess seismic hazard, hazardous natural phenomena such as earthquakes, as well as some man-made hazards and etc. The problem of measuring and accounting for the scattering power of the earth's surface in the short-range of radio waves is important for a number of purposes, such as diagnosing properties of the medium, which is of interest for geological, environmental studies. In this paper, we propose a new method for estimating the parameters of incoherent signal/noise ratio. The paper presents the results of comparison of the measurement method from the point of view of their admissible relative analytical errors. The new method is suggested. Analysis of analytical error of estimation of this parameter allowed to recommend new method instead of standard method. A comparative analysis and shows that the analytical (relative) accuracy of the determination of this parameter new method on the order exceeds the widely-used standard method.

  8. EMPIRE: A code for nuclear astrophysics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Palumbo, A.

    The nuclear reaction code EMPIRE is presented as a useful tool for nuclear astrophysics. EMPIRE combines a variety of the reaction models with a comprehensive library of input parameters providing a diversity of options for the user. With exclusion of the directsemidirect capture all reaction mechanisms relevant to the nuclear astrophysics energy range of interest are implemented in the code. Comparison to experimental data show consistent agreement for all relevant channels.

  9. Prediction of pump cavitation performance

    NASA Technical Reports Server (NTRS)

    Moore, R. D.

    1974-01-01

    A method for predicting pump cavitation performance with various liquids, liquid temperatures, and rotative speeds is presented. Use of the method requires that two sets of test data be available for the pump of interest. Good agreement between predicted and experimental results of cavitation performance was obtained for several pumps operated in liquids which exhibit a wide range of properties. Two cavitation parameters which qualitatively evaluate pump cavitation performance are also presented.

  10. Comparison of three methods reducing the beam parameter product of a laser diode stack for long range laser illumination applications

    NASA Astrophysics Data System (ADS)

    Lutz, Yves; Poyet, Jean-Michel; Metzger, Nicolas

    2013-10-01

    Laser diode stacks are interesting laser sources for active imaging illuminators. They allow the accumulation of large amounts of energy in multi-pulse mode, which is well suited for long-range image recording. Even when laser diode stacks are equipped with fast-axis collimation (FAC) and slow-axis collimation (SAC) microlenses, their beam parameter product (BPP) are not compatible with a direct use in highly efficient and compact illuminators. This is particularly true when narrow divergences are required such as for long range applications. To overcome these difficulties, we conducted investigations in three different ways. A first near infrared illuminator based on the use of conductively cooled mini-bars was designed, realized and successfully tested during outdoor experimentations. This custom specified stack was then replaced in a second step by an off-the-shelf FAC + SAC micro lensed stack where the brightness was increased by polarization overlapping. The third method still based on a commercial laser diode stack uses a non imaging optical shaping principle resulting in a virtually restacked laser source with enhanced beam parameters. This low cost, efficient and low alignment sensitivity beam shaping method allows obtaining a compact and high performance laser diode illuminator for long range active imaging applications. The three methods are presented and compared in this paper.

  11. The dynamics of Black Smokers: a heated-salty plume analog.

    NASA Astrophysics Data System (ADS)

    Maxworthy, Tony

    2004-11-01

    Experiments have been carried out on the dynamical processes that govern the evolution of hot, salty plumes injected into cold surroundings. Under the appropriate circumstances these are then used as an analoque system to understand some features of particle-laden, deep-ocean, hydrothermal plumes, e.g., Black Smokers. Details of the temperature distributions over a wide range of parameters are presented and these, coupled with flow visualization experiments, have yielded a fairly complete picture of the important features of the flow. As a result it has been concluded that cabelling processes are critical to an understanding of the flow reversals found in a certain parameter range and that double diffusive processes, though present, are of minor importance. As a final exercise an example is worked through in which the circumstances for flow reversal in deep-sea plumes have been estimated based on the best available knowledge of these interesting entities.

  12. In vivo spectroscopy of healthy skin and pathology in terahertz frequency range

    NASA Astrophysics Data System (ADS)

    Zaytsev, Kirill I.; Kudrin, Konstantin G.; Reshetov, Igor V.; Gavdush, Arseniy A.; Chernomyrdin, Nikita V.; Karasik, Valeriy E.; Yurchenko, Stanislav O.

    2015-01-01

    Biomedical applications of terahertz (THz) technology and, in particular, THz pulsed spectroscopy have attracted considerable interest in the scientific community. A lot of papers have been dedicated to studying the ability for human disease diagnosis, including the diagnosis of human skin cancers. In this paper we have studied the THz material parameters and THz dielectric properties of human skin and pathology in vivo, and THz pulsed spectroscopy has been utilized for this purpose. We have found a contrast between material parameters of basal cell carcinoma and healthy skin, and we have also compared the THz material parameters of dysplastic and non-dysplastic pigmentary nevi in order to study the ability for early melanoma diagnosis. Significant differences between the THz material parameters of healthy skin and pathology have been detected, thus, THz pulsed spectroscopy promises to be become an effective tool for non-invasive diagnosis of skin neoplasms.

  13. Quantization of parameters and the string landscape problem

    NASA Astrophysics Data System (ADS)

    Bouhmadi-López, Mariam; Vargas Moniz, Paulo

    2007-05-01

    We broaden the domain of application of Brustein and de Alwis's recent paper, where they introduce a (dynamical) selection principle on the landscape of string solutions using FRW quantum cosmology. More precisely, we (i) explain how their analysis is based in choosing a restrictive range of parameters, thereby affecting the validity of the predictions extracted and (ii) subsequently provide a wider and cohesive description, regarding the probability distribution induced by quantum cosmological transition amplitudes. In addition, employing DeWitt's argument for an initial condition on the wavefunction of the Universe, we found that the string and gravitational parameters become related through interesting expressions involving an integer n, suggesting a quantization relation for some of the involved parameters. This research work was supported by the grants POCI/FP/63916/2005, FEDER-POCI/P/FIS/57547/2004 and Acções Integradas (CRUP-CSIC) Luso-Espanholas E-138/04.

  14. Comparison of the surface dielectric barrier discharge characteristics under different electrode gaps

    NASA Astrophysics Data System (ADS)

    Gao, Guoqiang; Dong, Lei; Peng, Kaisheng; Wei, Wenfu; Li, Chunmao; Wu, Guangning

    2017-01-01

    Currently, great interests are paid to the surface dielectric barrier discharge due to the diverse and interesting application. In this paper, the influences of the electrode gap on the discharge characteristics have been studied. Aspects of the electrical parameters, the optical emission, and the discharge induced gas flow were considered. The electrode gap varied from 0 mm to 21 mm, while the applied AC voltage was studied in the range of 17 kV-27 kV. Results indicate that with the increase of the electrode gap, the variation of discharge voltage exhibits an increasing trend, while the other parameters (i.e., the current, power, and induced flow velocity) increase first, and then decrease once the gap exceeded the critical value. Mechanisms of the electrode gap influencing these key parameters were discussed from the point of equivalent circuit. The experimental results reveal that an optimal discharge gap can be obtained, which is closely related to the applied voltage. Visualization of the induced flow with different electrode gaps was realized by the Schlieren diagnostic technique. Finally, the velocities of induced gas flow determined by the pitot tube were compared with the results of intensity-integral method, and good agreements were found.

  15. Sensitivity of low-energy incomplete fusion to various entrance-channel parameters

    NASA Astrophysics Data System (ADS)

    Kumar, Harish; Tali, Suhail A.; Afzal Ansari, M.; Singh, D.; Ali, Rahbar; Kumar, Kamal; Sathik, N. P. M.; Ali, Asif; Parashari, Siddharth; Dubey, R.; Bala, Indu; Kumar, R.; Singh, R. P.; Muralithar, S.

    2018-03-01

    The disentangling of incomplete fusion dependence on various entrance channel parameters has been made from the forward recoil range distribution measurement for the 12C+175Lu system at ≈ 88 MeV energy. It gives the direct measure of full and/or partial linear momentum transfer from the projectile to the target nucleus. The comparison of observed recoil ranges with theoretical ranges calculated using the code SRIM infers the production of evaporation residues via complete and/or incomplete fusion process. Present results show that incomplete fusion process contributes significantly in the production of α xn and 2α xn emission channels. The deduced incomplete fusion probability (F_{ICF}) is compared with that obtained for systems available in the literature. An interesting behavior of F_{ICF} with ZP ZT is observed in the reinvestigation of incomplete fusion dependency with the Coulomb factor (ZPZT), contrary to the recent observations. The present results based on (ZPZT) are found in good agreement with recent observations of our group. A larger F_{ICF} value for 12C induced reactions is found than that for 13C, although both have the same ZPZT. A nonsystematic behavior of the incomplete fusion process with the target deformation parameter (β2) is observed, which is further correlated with a new parameter (ZP ZT . β2). The projectile α -Q-value is found to explain more clearly the discrepancy observed in incomplete fusion dependency with parameters ( ZPZT) and (ZP ZT . β2). It may be pointed out that any single entrance channel parameter (mass-asymmetry or (ZPZT) or β2 or projectile α-Q-value) may not be able to explain completely the incomplete fusion process.

  16. Target discrimination strategies in optics detection

    NASA Astrophysics Data System (ADS)

    Sjöqvist, Lars; Allard, Lars; Henriksson, Markus; Jonsson, Per; Pettersson, Magnus

    2013-10-01

    Detection and localisation of optical assemblies used for weapon guidance or sniper rifle scopes has attracted interest for security and military applications. Typically a laser system is used to interrogate a scene of interest and the retro-reflected radiation is detected. Different system approaches for area coverage can be realised ranging from flood illumination to step-and-stare or continuous scanning schemes. Independently of the chosen approach target discrimination is a crucial issue, particularly if a complex scene such as in an urban environment and autonomous operation is considered. In this work target discrimination strategies in optics detection are discussed. Typical parameters affecting the reflected laser radiation from the target are the wavelength, polarisation properties, temporal effects and the range resolution. Knowledge about the target characteristics is important to predict the target discrimination capability. Two different systems were used to investigate polarisation properties and range resolution information from targets including e.g. road signs, optical reflexes, rifle sights and optical references. The experimental results and implications on target discrimination will be discussed. If autonomous operation is required target discrimination becomes critical in order to reduce the number of false alarms.

  17. 78 FR 42579 - Self-Regulatory Organizations; Chicago Mercantile Exchange Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... Change Regarding a Change to Interest Rate Swap Margin Calculation Parameters July 10, 2013. Pursuant to... Interest Rate Swap Margin Parameters Please be advised that beginning 7/15/2013, CME Clearing will utilize a revised set of parameters for the margining of CME cleared Interest Rate Swap Products. The...

  18. plasticity of TGF-β signaling

    PubMed Central

    2011-01-01

    Background The family of TGF-β ligands is large and its members are involved in many different signaling processes. These signaling processes strongly differ in type with TGF-β ligands eliciting both sustained or transient responses. Members of the TGF-β family can also act as morphogen and cellular responses would then be expected to provide a direct read-out of the extracellular ligand concentration. A number of different models have been proposed to reconcile these different behaviours. We were interested to define the set of minimal modifications that are required to change the type of signal processing in the TGF-β signaling network. Results To define the key aspects for signaling plasticity we focused on the core of the TGF-β signaling network. With the help of a parameter screen we identified ranges of kinetic parameters and protein concentrations that give rise to transient, sustained, or oscillatory responses to constant stimuli, as well as those parameter ranges that enable a proportional response to time-varying ligand concentrations (as expected in the read-out of morphogens). A combination of a strong negative feedback and fast shuttling to the nucleus biases signaling to a transient rather than a sustained response, while oscillations were obtained if ligand binding to the receptor is weak and the turn-over of the I-Smad is fast. A proportional read-out required inefficient receptor activation in addition to a low affinity of receptor-ligand binding. We find that targeted modification of single parameters suffices to alter the response type. The intensity of a constant signal (i.e. the ligand concentration), on the other hand, affected only the strength but not the type of the response. Conclusions The architecture of the TGF-β pathway enables the observed signaling plasticity. The observed range of signaling outputs to TGF-β ligand in different cell types and under different conditions can be explained with differences in cellular protein concentrations and with changes in effective rate constants due to cross-talk with other signaling pathways. It will be interesting to uncover the exact cellular differences as well as the details of the cross-talks in future work. PMID:22051045

  19. Cavitation-threshold Determination and Rheological-parameters Estimation of Albumin-stabilized Nanobubbles.

    PubMed

    Lafond, Maxime; Watanabe, Akiko; Yoshizawa, Shin; Umemura, Shin-Ichiro; Tachibana, Katsuro

    2018-05-10

    Nanobubbles (NBs) are of high interest for ultrasound (US) imaging as contrast agents and therapy as cavitation nuclei. Because of their instability (Laplace pressure bubble catastrophe) and low sensitivity to US, reducing the size of commonly used microbubbles to submicron-size is not trivial. We introduce stabilized NBs in the 100-250-nm size range, manufactured by agitating human serum albumin and perfluoro-propane. These NBs were exposed to 3.34- and 5.39-MHz US, and their sensitivity to US was proven by detecting inertial cavitation. The cavitation-threshold information was used to run a numerical parametric study based on a modified Rayleigh-Plesset equation (with a Newtonian rheology model). The determined values of surface tension ranged from 0 N/m to 0.06 N/m. The corresponding values of dilatational viscosity ranged from 5.10 -10 Ns/m to 1.10 -9 Ns/m. These parameters were reported to be 0.6 N/m and 1.10 -8 Ns/m for the reference microbubble contrast agent. This result suggests the possibility of using albumin as a stabilizer for the nanobubbles that could be maintained in circulation and presenting satisfying US sensitivity, even in the 3-5-MHz range.

  20. Modelling opinion formation driven communities in social networks

    NASA Astrophysics Data System (ADS)

    Iñiguez, Gerardo; Barrio, Rafael A.; Kertész, János; Kaski, Kimmo K.

    2011-09-01

    In a previous paper we proposed a model to study the dynamics of opinion formation in human societies by a co-evolution process involving two distinct time scales of fast transaction and slower network evolution dynamics. In the transaction dynamics we take into account short range interactions as discussions between individuals and long range interactions to describe the attitude to the overall mood of society. The latter is handled by a uniformly distributed parameter α, assigned randomly to each individual, as quenched personal bias. The network evolution dynamics is realised by rewiring the societal network due to state variable changes as a result of transaction dynamics. The main consequence of this complex dynamics is that communities emerge in the social network for a range of values in the ratio between time scales. In this paper we focus our attention on the attitude parameter α and its influence on the conformation of opinion and the size of the resulting communities. We present numerical studies and extract interesting features of the model that can be interpreted in terms of social behaviour.

  1. Sensitivity Analysis of the Land Surface Model NOAH-MP for Different Model Fluxes

    NASA Astrophysics Data System (ADS)

    Mai, Juliane; Thober, Stephan; Samaniego, Luis; Branch, Oliver; Wulfmeyer, Volker; Clark, Martyn; Attinger, Sabine; Kumar, Rohini; Cuntz, Matthias

    2015-04-01

    Land Surface Models (LSMs) use a plenitude of process descriptions to represent the carbon, energy and water cycles. They are highly complex and computationally expensive. Practitioners, however, are often only interested in specific outputs of the model such as latent heat or surface runoff. In model applications like parameter estimation, the most important parameters are then chosen by experience or expert knowledge. Hydrologists interested in surface runoff therefore chose mostly soil parameters while biogeochemists interested in carbon fluxes focus on vegetation parameters. However, this might lead to the omission of parameters that are important, for example, through strong interactions with the parameters chosen. It also happens during model development that some process descriptions contain fixed values, which are supposedly unimportant parameters. However, these hidden parameters remain normally undetected although they might be highly relevant during model calibration. Sensitivity analyses are used to identify informative model parameters for a specific model output. Standard methods for sensitivity analysis such as Sobol indexes require large amounts of model evaluations, specifically in case of many model parameters. We hence propose to first use a recently developed inexpensive sequential screening method based on Elementary Effects that has proven to identify the relevant informative parameters. This reduces the number parameters and therefore model evaluations for subsequent analyses such as sensitivity analysis or model calibration. In this study, we quantify parametric sensitivities of the land surface model NOAH-MP that is a state-of-the-art LSM and used at regional scale as the land surface scheme of the atmospheric Weather Research and Forecasting Model (WRF). NOAH-MP contains multiple process parameterizations yielding a considerable amount of parameters (˜ 100). Sensitivities for the three model outputs (a) surface runoff, (b) soil drainage and (c) latent heat are calculated on twelve Model Parameter Estimation Experiment (MOPEX) catchments ranging in size from 1020 to 4421 km2. This allows investigation of parametric sensitivities for distinct hydro-climatic characteristics, emphasizing different land-surface processes. The sequential screening identifies the most informative parameters of NOAH-MP for different model output variables. The number of parameters is reduced substantially for all of the three model outputs to approximately 25. The subsequent Sobol method quantifies the sensitivities of these informative parameters. The study demonstrates the existence of sensitive, important parameters in almost all parts of the model irrespective of the considered output. Soil parameters, e.g., are informative for all three output variables whereas plant parameters are not only informative for latent heat but also for soil drainage because soil drainage is strongly coupled to transpiration through the soil water balance. These results contrast to the choice of only soil parameters in hydrological studies and only plant parameters in biogeochemical ones. The sequential screening identified several important hidden parameters that carry large sensitivities and have hence to be included during model calibration.

  2. Application of Optical Imaging Techniques for Quantification of pH and O2 Dynamicsin Porous Media

    NASA Astrophysics Data System (ADS)

    Li, B.; Seliman, A. F.; Pales, A. R.; Liang, W.; Sams, A.; Darnault, C. J. G.; DeVol, T. A.

    2016-12-01

    Understanding the spatial and temporal distribution of physical and chemical parameters (e.g. pH, O2) is imperative to characterize the behavior of contaminants in a natural environment. The objectives of this research are to calibrate pH and O2 sensor foils, to develop a dual pH/O2 sensor foil, and to apply them into flow and transport experiments, in order to understand the physical and chemical parameters that control contaminant fate and transport in an unsaturated sandy porous medium. In addition, demonstration of a sensor foil that quantifies aqueous uranium concentration will be presented. Optical imaging techniques will be conducted with 2D tanks to investigate the influence of microbial exudates and plant roots on pH and O2 parameters and radionuclides transport. As a non-invasive method, the optical imaging technique utilizes optical chemical sensor films and either a digital camera or a spectrometer to capture the changes with high temporal and spatial resolutions. Sensor foils are made for different parameters by applying dyes to generate favorable fluorescence that is proportional to the parameter of interest. Preliminary results suggested that this method could detect pH ranging from 4.5 to 7.5. The result from uranium foil test with different concentrations in the range of 2 to 8 ppm indicated that a higher concentration of uranium resulted in a greater color intensity.

  3. Estimating hydraulic parameters of a heterogeneous aquitard using long-term multi-extensometer and groundwater level data

    NASA Astrophysics Data System (ADS)

    Zhuang, Chao; Zhou, Zhifang; Illman, Walter A.; Guo, Qiaona; Wang, Jinguo

    2017-09-01

    The classical aquitard-drainage model COMPAC has been modified to simulate the compaction process of a heterogeneous aquitard consisting of multiple sub-units (Multi-COMPAC). By coupling Multi-COMPAC with the parameter estimation code PEST++, the vertical hydraulic conductivity ( K v) and elastic ( S ske) and inelastic ( S skp) skeletal specific-storage values of each sub-unit can be estimated using observed long-term multi-extensometer and groundwater level data. The approach was first tested through a synthetic case with known parameters. Results of the synthetic case revealed that it was possible to accurately estimate the three parameters for each sub-unit. Next, the methodology was applied to a field site located in Changzhou city, China. Based on the detailed stratigraphic information and extensometer data, the aquitard of interest was subdivided into three sub-units. Parameters K v, S ske and S skp of each sub-unit were estimated simultaneously and then were compared with laboratory results and with bulk values and geologic data from previous studies, demonstrating the reliability of parameter estimates. Estimated S skp values ranged within the magnitude of 10-4 m-1, while K v ranged over 10-10-10-8 m/s, suggesting moderately high heterogeneity of the aquitard. However, the elastic deformation of the third sub-unit, consisting of soft plastic silty clay, is masked by delayed drainage, and the inverse procedure leads to large uncertainty in the S ske estimate for this sub-unit.

  4. An Approximate Solution and Master Curves for Buckling of Symmetrically Laminated Composite Cylinders

    NASA Technical Reports Server (NTRS)

    Nemeth, Michael P.

    2013-01-01

    Nondimensional linear-bifurcation buckling equations for balanced, symmetrically laminated cylinders with negligible shell-wall anisotropies and subjected to uniform axial compression loads are presented. These equations are solved exactly for the practical case of simply supported ends. Nondimensional quantities are used to characterize the buckling behavior that consist of a stiffness-weighted length-to-radius parameter, a stiffness-weighted shell-thinness parameter, a shell-wall nonhomogeneity parameter, two orthotropy parameters, and a nondimensional buckling load. Ranges for the nondimensional parameters are established that encompass a wide range of laminated-wall constructions and numerous generic plots of nondimensional buckling load versus a stiffness-weighted length-to-radius ratio are presented for various combinations of the other parameters. These plots are expected to include many practical cases of interest to designers. Additionally, these plots show how the parameter values affect the distribution and size of the festoons forming each response curve and how they affect the attenuation of each response curve to the corresponding solution for an infinitely long cylinder. To aid in preliminary design studies, approximate formulas for the nondimensional buckling load are derived, and validated against the corresponding exact solution, that give the attenuated buckling response of an infinitely long cylinder in terms of the nondimensional parameters presented herein. A relatively small number of "master curves" are identified that give a nondimensional measure of the buckling load of an infinitely long cylinder as a function of the orthotropy and wall inhomogeneity parameters. These curves reduce greatly the complexity of the design-variable space as compared to representations that use dimensional quantities as design variables. As a result of their inherent simplicity, these master curves are anticipated to be useful in the ongoing development of buckling-design technology.

  5. Protection from visible light by commonly used textiles is not predicted by ultraviolet protection.

    PubMed

    Van den Keybus, Caroline; Laperre, Jan; Roelandts, Rik

    2006-01-01

    Interest is increasing in the prevention of acute and chronic actinic damage provided by clothing. This interest has focused mainly on protection against ultraviolet irradiation, but it has now also turned to protection against visible light. This change is mainly due to the action spectrum in the visible light range of some photodermatoses and the increasing interest in photodynamic therapy. The ultraviolet protection provided by commercially available textiles can be graded by determining an ultraviolet protection factor. Several methods have already been used to determine the ultraviolet protection factor. The fact that protection from visible light by textiles cannot be predicted by their ultraviolet protection makes the situation more complicated. This study attempts to determine whether or not the ultraviolet protection factor value of a particular textile is a good parameter for gauging its protection in the visible light range and concludes that a protection factor of textile materials against visible light needs to be developed. This development should go beyond the protection factor definition used in this article, which has some limitations, and should take into account the exact action spectrum for which the protection is needed.

  6. Improving land surface parameter retrieval by integrating plant traits priors in the MULTIPLY data assimilation platform

    NASA Astrophysics Data System (ADS)

    Corbin, A. E.; Timmermans, J.; Hauser, L.; Bodegom, P. V.; Soudzilovskaia, N. A.

    2017-12-01

    There is a growing demand for accurate land surface parameterization from remote sensing (RS) observations. This demand has not been satisfied, because most estimation schemes apply 1) a single-sensor single-scale approach, and 2) require specific key-variables to be `guessed'. This is because of the relevant observational information required to accurately retrieve parameters of interest. Consequently, many schemes assume specific variables to be constant or not present; subsequently leading to more uncertainty. In this aspect, the MULTIscale SENTINEL land surface information retrieval Platform (MULTIPLY) was created. MULTIPLY couples a variety of RS sources with Radiative Transfer Models (RTM) over varying spectral ranges using data-assimilation to estimate geophysical parameters. In addition, MULTIPLY also uses prior information about the land surface to constrain the retrieval problem. This research aims to improve the retrieval of plant biophysical parameters through the use of priors of biophysical parameters/plant traits. Of particular interest are traits (physical, morphological or chemical trait) affecting individual performance and fitness of species. Plant traits that are able to be retrieved via RS and with RTMs include traits such as leaf-pigments, leaf water, LAI, phenols, C/N, etc. In-situ data for plant traits that are retrievable via RS techniques were collected for a meta-analysis from databases such as TRY, Ecosis, and individual collaborators. Of particular interest are the following traits: chlorophyll, carotenoids, anthocyanins, phenols, leaf water, and LAI. ANOVA statistics were generated for each traits according to species, plant functional groups (such as evergreens, grasses, etc.), and the trait itself. Afterwards, traits were also compared using covariance matrices. Using these as priors, MULTIPLY was is used to retrieve several plant traits in two validation sites in the Netherlands (Speulderbos) and in Finland (Sodankylä). Initial comparisons show significant improved results over non-a priori based retrievals.

  7. Development of Carbotrap B-packed needle trap device for determination of volatile organic compounds in air.

    PubMed

    Poormohammadi, Ali; Bahrami, Abdulrahman; Farhadian, Maryam; Ghorbani Shahna, Farshid; Ghiasvand, Alireza

    2017-12-08

    Carbotrap B as a highly pure surface sorbent with excellent adsorption/desorption properties was packed into a stainless steel needle to develop a new needle trap device (NTD). The performance of the prepared NTD was investigated for sampling, pre-concentration and injection of benzene, toluene, ethyl benzene, o-xylene, and p-xylene (BTEX) into the column of gas chromatography-mass spectrometry (GC-MS) device. Response surface methodology (RSM) with central composite design (CCD) was also employed in two separate consecutive steps to optimize the sampling and device parameters. First, the sampling parameters such as sampling temperature and relative humidity were optimized. Afterwards, the RSM was used for optimizing the desorption parameters including desorption temperature and time. The results indicated that the peak area responses of the analytes of interest decreased with increasing sampling temperature and relative humidity. The optimum values of desorption temperature were in the range 265-273°C, and desorption time were in the range 3.4-3.8min. The limits of detection (LODs) and limits of quantitation (LOQs) of the studied analytes were found over the range of 0.03-0.04ng/mL, and 0.1-0.13ng/mL, respectively. These results demonstrated that the NTD packed with Carbotrap B offers a high sensitive procedure for sampling and analysis of BTEX in concentration range of 0.03-25ng/mL in air. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Variations in Ratio and Correlation of Solar Magnetic Fields in the Fe i 525.02 nm and Na i 589.59 nm Lines According to Mount Wilson Measurements During 2000 - 2012

    NASA Astrophysics Data System (ADS)

    Golubeva, Elena

    2016-10-01

    Variations in the solar magnetic-field ratio over 13 years are analyzed, relying on the comparison of simultaneous measurements in two spectral lines at the Mount Wilson Observatory (MWO). The ratio and correlation coefficient are calculated over the general working range of measured magnetic-field values and in various ranges of the field magnitudes. Variations in both parameters are considered. We found the following tendencies: i) the parameters show changes with the cycle of solar activity in the general case; ii) their dependence on magnetic-field magnitude is a nonlinear function of time, and this is especially pronounced in the ratio behavior; iii) several separate ranges of the field magnitudes can be distinguished based on the behavioral patterns of the ratio variations. Correspondences between these ranges and the known structural objects of the solar atmosphere are discussed. This permits us to reach the conclusion that the dependence of parameters considered on the magnetic-field magnitude and time is connected with the variety of magnetic structural components and their cyclic rearrangements. The results represented may be useful for solving interpretation problems of solar magnetic-field measurements and for the cross-calibration of applicable instruments. They can also be of interest for tasks related to the creation of a uniform long temporal series of solar magnetic-field data from various sources.

  9. Temperature Dependent Rubidium Helium Line Shapes and Fine Structure Mixing Rates

    DTIC Science & Technology

    2015-09-01

    that uses alkali metal vapor as a gain medium and a buffer gas to control the line shape and kinetics. While these systems were first demonstrated in...noble gas interactions with a high degree of accuracy. The physical parameters of interest here include pressure broadening (γ), pressure shift (δ...optical transitions between the two excited states. This collisional partner is a gas mixture that is pumped into the cell. The gases used range from

  10. Temperature Dependent Rubidium-Helium Line Shapes and Fine Structure Mixing Rates

    DTIC Science & Technology

    2015-09-17

    that uses alkali metal vapor as a gain medium and a buffer gas to control the line shape and kinetics. While these systems were first demonstrated in...noble gas interactions with a high degree of accuracy. The physical parameters of interest here include pressure broadening (γ), pressure shift (δ...optical transitions between the two excited states. This collisional partner is a gas mixture that is pumped into the cell. The gases used range from

  11. Baseline estimation from simultaneous satellite laser tracking

    NASA Technical Reports Server (NTRS)

    Dedes, George C.

    1987-01-01

    Simultaneous Range Differences (SRDs) to Lageos are obtained by dividing the observing stations into pairs with quasi-simultaneous observations. For each of those pairs the station with the least number of observations is identified, and at its observing epochs interpolated ranges for the alternate station are generated. The SRD observables are obtained by subtracting the actually observed laser range of the station having the least number of observations from the interpolated ranges of the alternate station. On the basis of these observables semidynamic single baseline solutions were performed. The aim of these solutions is to further develop and implement the SRD method in the real data environment, to assess its accuracy, its advantages and disadvantages as related to the range dynamic mode methods, when the baselines are the only parameters of interest. Baselines, using simultaneous laser range observations to Lageos, were also estimated through the purely geometric method. These baselines formed the standards the standards of comparison in the accuracy assessment of the SRD method when compared to that of the range dynamic mode methods. On the basis of this comparison it was concluded that for baselines of regional extent the SRD method is very effective, efficient, and at least as accurate as the range dynamic mode methods, and that on the basis of a simple orbital modeling and a limited orbit adjustment. The SRD method is insensitive to the inconsistencies affecting the terrestrial reference frame and simultaneous adjustment of the Earth Rotation Parameters (ERPs) is not necessary.

  12. A comparison of simple global kinetic models for coal devolatilization with the CPD model

    DOE PAGES

    Richards, Andrew P.; Fletcher, Thomas H.

    2016-08-01

    Simulations of coal combustors and gasifiers generally cannot incorporate the complexities of advanced pyrolysis models, and hence there is interest in evaluating simpler models over ranges of temperature and heating rate that are applicable to the furnace of interest. In this paper, six different simple model forms are compared to predictions made by the Chemical Percolation Devolatilization (CPD) model. The model forms included three modified one-step models, a simple two-step model, and two new modified two-step models. These simple model forms were compared over a wide range of heating rates (5 × 10 3 to 10 6 K/s) at finalmore » temperatures up to 1600 K. Comparisons were made of total volatiles yield as a function of temperature, as well as the ultimate volatiles yield. Advantages and disadvantages for each simple model form are discussed. In conclusion, a modified two-step model with distributed activation energies seems to give the best agreement with CPD model predictions (with the fewest tunable parameters).« less

  13. Coarsening dynamics in condensing zero-range processes and size-biased birth death chains

    NASA Astrophysics Data System (ADS)

    Jatuviriyapornchai, Watthanan; Grosskinsky, Stefan

    2016-05-01

    Zero-range processes with decreasing jump rates are well known to exhibit a condensation transition under certain conditions on the jump rates, and the dynamics of this transition continues to be a subject of current research interest. Starting from homogeneous initial conditions, the time evolution of the condensed phase exhibits an interesting coarsening phenomenon of mass transport between cluster sites characterized by a power law. We revisit the approach in Godrèche (2003 J. Phys. A: Math. Gen. 36 6313) to derive effective single site dynamics which form a nonlinear birth death chain describing the coarsening behavior. We extend these results to a larger class of parameter values, and introduce a size-biased version of the single site process, which provides an effective tool to analyze the dynamics of the condensed phase without finite size effects and is the main novelty of this paper. Our results are based on a few heuristic assumptions and exact computations, and are corroborated by detailed simulation data.

  14. Health technology adoption and the politics of governance in the UK.

    PubMed

    Milewa, Timothy

    2006-12-01

    The manner in which clinical and cost-effectiveness data are used to inform decisions about the funding and availability of drugs, therapies and medical devices is inherently politicised within collectively financed systems of health care. The National Institute for Health and Clinical Excellence (NICE) was established by the British government in 1999 to reach evidence-based decisions on whether selected health technologies should be made available by the National Health Service in England and Wales. But NICE is also required to involve a broad range of interested parties in the decision-making process, provide detailed rationales for its rulings and defend appeals from aggrieved parties. Debates about the emergence of "deliberative" forms of policy governance--based upon participation by a broad range of stakeholders rather than reliance on scientific, bureaucratic or political expertise alone--are thus particularly apposite. This article draws on a study of decision-making within NICE by focusing upon the tenor and orientation of deliberation about the adoption of health technologies. Does such deliberation take place upon a level playing field for different interests? Or do implicit parameters and understandings in the deliberative process tend to privilege some interests by structuring debate and attendant outcomes? Findings suggest that deliberative assumptions and parameters pertaining to fluid and contestable ideas of transparent reasoning and domain competence both reflect and shape relationships of influence and marginality among participants. Broader analytical implications centre on a distinction between "deliberative democracy" and "democratic deliberation". The extent to which this distinction is acknowledged and addressed in policy and practise will have marked implications for the substantive nature of attempts to broaden involvement in decision-making within public sector bodies such as NICE.

  15. Multiple linear regression approach for the analysis of the relationships between joints mobility and regional pressure-based parameters in the normal-arched foot.

    PubMed

    Caravaggi, Paolo; Leardini, Alberto; Giacomozzi, Claudia

    2016-10-03

    Plantar load can be considered as a measure of the foot ability to transmit forces at the foot/ground, or foot/footwear interface during ambulatory activities via the lower limb kinematic chain. While morphological and functional measures have been shown to be correlated with plantar load, no exhaustive data are currently available on the possible relationships between range of motion of foot joints and plantar load regional parameters. Joints' kinematics from a validated multi-segmental foot model were recorded together with plantar pressure parameters in 21 normal-arched healthy subjects during three barefoot walking trials. Plantar pressure maps were divided into six anatomically-based regions of interest associated to corresponding foot segments. A stepwise multiple regression analysis was performed to determine the relationships between pressure-based parameters, joints range of motion and normalized walking speed (speed/subject height). Sagittal- and frontal-plane joint motion were those most correlated to plantar load. Foot joints' range of motion and normalized walking speed explained between 6% and 43% of the model variance (adjusted R 2 ) for pressure-based parameters. In general, those joints' presenting lower mobility during stance were associated to lower vertical force at forefoot and to larger mean and peak pressure at hindfoot and forefoot. Normalized walking speed was always positively correlated to mean and peak pressure at hindfoot and forefoot. While a large variance in plantar pressure data is still not accounted for by the present models, this study provides statistical corroboration of the close relationship between joint mobility and plantar pressure during stance in the normal healthy foot. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Quadratic semiparametric Von Mises calculus

    PubMed Central

    Robins, James; Li, Lingling; Tchetgen, Eric

    2009-01-01

    We discuss a new method of estimation of parameters in semiparametric and nonparametric models. The method is based on U-statistics constructed from quadratic influence functions. The latter extend ordinary linear influence functions of the parameter of interest as defined in semiparametric theory, and represent second order derivatives of this parameter. For parameters for which the matching cannot be perfect the method leads to a bias-variance trade-off, and results in estimators that converge at a slower than n–1/2-rate. In a number of examples the resulting rate can be shown to be optimal. We are particularly interested in estimating parameters in models with a nuisance parameter of high dimension or low regularity, where the parameter of interest cannot be estimated at n–1/2-rate. PMID:23087487

  17. Differential Geometry Applied To Least-Square Error Surface Approximations

    NASA Astrophysics Data System (ADS)

    Bolle, Ruud M.; Sabbah, Daniel

    1987-08-01

    This paper focuses on extraction of the parameters of individual surfaces from noisy depth maps. The basis for this are least-square error polynomial approximations to the range data and the curvature properties that can be computed from these approximations. The curvature properties are derived using the invariants of the Weingarten Map evaluated at the origin of local coordinate systems centered at the range points. The Weingarten Map is a well-known concept in differential geometry; a brief treatment of the differential geometry pertinent to surface curvature is given. We use the curvature properties for extracting certain surface parameters from the curvature properties of the approximations. Then we show that curvature properties alone are not enough to obtain all the parameters of the surfaces; higher order properties (information about change of curvature) are needed to obtain full parametric descriptions. This surface parameter estimation problem arises in the design of a vision system to recognize 3D objects whose surfaces are composed of planar patches and patches of quadrics of revolution. (Quadrics of revolution are quadrics that are surfaces of revolution.) A significant portion of man-made objects can be modeled using these surfaces. The actual process of recognition and parameter extraction is framed as a set of stacked parameter space transforms. The transforms are "stacked" in the sense that any one transform computes only a partial geometric description that forms the input to the next transform. Those who are interested in the organization and control of the recognition and parameter recognition process are referred to [Sabbah86], this paper briefly touches upon the organization, but concentrates mainly on geometrical aspects of the parameter extraction.

  18. SiC/SiC Composites: The Effect of Fiber Type and Fiber Architecture on Mechanical Properties

    NASA Technical Reports Server (NTRS)

    Morscher, Gregory N.

    2008-01-01

    Woven SiC/SiC composites represent a broad family of composites with a broad range of properties which are of interest for many energy-based and aero-based applications. Two important features of SiC/SiC composites which one must consider are the reinforcing fibers themselves and the fiber-architecture they are formed into. The range of choices for these two features can result in a wide range of elastic, mechanical, thermal, and electrical properties. In this presentation, it will be demonstrated how the effect of fiber-type and fiber architecture effects the important property of "matrix cracking stress" for slurry-cast melt-infiltrated SiC matrix composites, which is often considered to be a critical design parameter for this system of composites.

  19. SU-E-T-254: Optimization of GATE and PHITS Monte Carlo Code Parameters for Uniform Scanning Proton Beam Based On Simulation with FLUKA General-Purpose Code

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kurosu, K; Department of Medical Physics ' Engineering, Osaka University Graduate School of Medicine, Osaka; Takashina, M

    Purpose: Monte Carlo codes are becoming important tools for proton beam dosimetry. However, the relationships between the customizing parameters and percentage depth dose (PDD) of GATE and PHITS codes have not been reported which are studied for PDD and proton range compared to the FLUKA code and the experimental data. Methods: The beam delivery system of the Indiana University Health Proton Therapy Center was modeled for the uniform scanning beam in FLUKA and transferred identically into GATE and PHITS. This computational model was built from the blue print and validated with the commissioning data. Three parameters evaluated are the maximummore » step size, cut off energy and physical and transport model. The dependence of the PDDs on the customizing parameters was compared with the published results of previous studies. Results: The optimal parameters for the simulation of the whole beam delivery system were defined by referring to the calculation results obtained with each parameter. Although the PDDs from FLUKA and the experimental data show a good agreement, those of GATE and PHITS obtained with our optimal parameters show a minor discrepancy. The measured proton range R90 was 269.37 mm, compared to the calculated range of 269.63 mm, 268.96 mm, and 270.85 mm with FLUKA, GATE and PHITS, respectively. Conclusion: We evaluated the dependence of the results for PDDs obtained with GATE and PHITS Monte Carlo generalpurpose codes on the customizing parameters by using the whole computational model of the treatment nozzle. The optimal parameters for the simulation were then defined by referring to the calculation results. The physical model, particle transport mechanics and the different geometrybased descriptions need accurate customization in three simulation codes to agree with experimental data for artifact-free Monte Carlo simulation. This study was supported by Grants-in Aid for Cancer Research (H22-3rd Term Cancer Control-General-043) from the Ministry of Health, Labor and Welfare of Japan, Grants-in-Aid for Scientific Research (No. 23791419), and JSPS Core-to-Core program (No. 23003). The authors have no conflict of interest.« less

  20. Drifting oscillations in axion monodromy

    DOE PAGES

    Flauger, Raphael; McAllister, Liam; Silverstein, Eva; ...

    2017-10-31

    In this paper, we study the pattern of oscillations in the primordial power spectrum in axion monodromy inflation, accounting for drifts in the oscillation period that can be important for comparing to cosmological data. In these models the potential energy has a monomial form over a super-Planckian field range, with superimposed modulations whose size is model-dependent. The amplitude and frequency of the modulations are set by the expectation values of moduli fields. We show that during the course of inflation, the diminishing energy density can induce slow adjustments of the moduli, changing the modulations. We provide templates capturing the effectsmore » of drifting moduli, as well as drifts arising in effective field theory models based on softly broken discrete shift symmetries, and we estimate the precision required to detect a drifting period. A non-drifting template suffices over a wide range of parameters, but for the highest frequencies of interest, or for sufficiently strong drift, it is necessary to include parameters characterizing the change in frequency over the e-folds visible in the CMB. Finally, we use these templates to perform a preliminary search for drifting oscillations in a part of the parameter space in the Planck nominal mission data.« less

  1. Time-varying BRDFs.

    PubMed

    Sun, Bo; Sunkavalli, Kalyan; Ramamoorthi, Ravi; Belhumeur, Peter N; Nayar, Shree K

    2007-01-01

    The properties of virtually all real-world materials change with time, causing their bidirectional reflectance distribution functions (BRDFs) to be time varying. However, none of the existing BRDF models and databases take time variation into consideration; they represent the appearance of a material at a single time instance. In this paper, we address the acquisition, analysis, modeling, and rendering of a wide range of time-varying BRDFs (TVBRDFs). We have developed an acquisition system that is capable of sampling a material's BRDF at multiple time instances, with each time sample acquired within 36 sec. We have used this acquisition system to measure the BRDFs of a wide range of time-varying phenomena, which include the drying of various types of paints (watercolor, spray, and oil), the drying of wet rough surfaces (cement, plaster, and fabrics), the accumulation of dusts (household and joint compound) on surfaces, and the melting of materials (chocolate). Analytic BRDF functions are fit to these measurements and the model parameters' variations with time are analyzed. Each category exhibits interesting and sometimes nonintuitive parameter trends. These parameter trends are then used to develop analytic TVBRDF models. The analytic TVBRDF models enable us to apply effects such as paint drying and dust accumulation to arbitrary surfaces and novel materials.

  2. Gas metal arc welding fume generation using pulsed current

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Castner, H.R.

    1994-12-31

    This paper describes a study of the effects of pulsed welding current on the amount of welding fume and ozone produced during gas metal arc welding (GMAW) using a range of welding procedures and pulse parameters. The results reported in this paper show that pulsed current can reduce GMAW fumes compared to steady current. This research also shows that welding parameters need to be properly controlled if pulsed current is to be used to reduce welding fumes. Fume and ozone generation rates were measured during this study for GMAW of mild steel using copper-coated ER70S-3 electrode wire and 95%Ar-5%CO{sub 2}more » and 85%Ar-15%CO{sub 2} shielding gases. Welds were made with both steady current and pulsed current over a wide range of welding parameters. Fume generation rates for steady current were found to be typically between 0.2 g/min and 0.8 g/min which agrees with other researchers. No significant difference was found in the chemical composition of welding fumes from pulsed current compared to the composition of fumes generated by steady current. New technology that can reduce arc welding fumes is of significant interest to a wide range of companies that use arc welding processes and this research should assist these users in evaluating the potential for the application of this technology to their own operations.« less

  3. The Smallest Lunar Grains: Analytical TEM Characterization of the Sub-micron Size Fraction of a Mare Soil

    NASA Technical Reports Server (NTRS)

    Thompson, M.; Christoffersen, R.

    2010-01-01

    The chemical composition, mineralogical type, and morphology of lunar regolith grains changes considerably with decreasing size, and below the approx.25 m size range the correlation between these parameters and remotely-sensed lunar surface properties connected to space weathering increases significantly. Although trends for these parameters across grain size intervals greater than 20 m are now well established, the 0 to 20 m size interval remains relatively un-subdivided with respect to variations in grain modal composition, chemistry and microstructure. Of particular interest in this size range are grains in the approximate < 1 m diameter class, whose fundamental properties are now the focus of lunar research pertaining to electrostatic grain transport, dusty plasmas, and lunar dust effects on crew health and exploration systems. In this study we have used analytical transmission electron microscopy (TEM) to characterize the mineralogy, microstructure and major element composition of grains below the 1 m size threshold in lunar soil 10084.

  4. Flight-Time Identification of a UH-60A Helicopter and Slung Load

    NASA Technical Reports Server (NTRS)

    Cicolani, Luigi S.; McCoy, Allen H.; Tischler, Mark B.; Tucker, George E.; Gatenio, Pinhas; Marmar, Dani

    1998-01-01

    This paper describes a flight test demonstration of a system for identification of the stability and handling qualities parameters of a helicopter-slung load configuration simultaneously with flight testing, and the results obtained.Tests were conducted with a UH-60A Black Hawk at speeds from hover to 80 kts. The principal test load was an instrumented 8 x 6 x 6 ft cargo container. The identification used frequency domain analysis in the frequency range to 2 Hz, and focussed on the longitudinal and lateral control axes since these are the axes most affected by the load pendulum modes in the frequency range of interest for handling qualities. Results were computed for stability margins, handling qualities parameters and load pendulum stability. The computations took an average of 4 minutes before clearing the aircraft to the next test point. Important reductions in handling qualities were computed in some cases, depending, on control axis and load-slung combination. A database, including load dynamics measurements, was accumulated for subsequent simulation development and validation.

  5. Energy in a Planetary Context

    NASA Technical Reports Server (NTRS)

    Hoehler, Tori M.

    2017-01-01

    The potential present day habitability of solar system bodies beyond Earth is limited to subsurface environments, where the availability of energy in biologically useful form is a paramount consideration. Energy availability is commonly quantified in terms of molar Gibbs energy changes for metabolisms of interest, but this can provide an incomplete and even misleading picture. A second aspect of life's requirement for energy - the rate of delivery, or power - strongly influences habitability, biomass abundance, growth rates, and, ultimately, rates of evolution. We are developing an approach to quantify metabolic power, using a cell-scale reactive transport model in which physical and chemical environmental parameters are varied. Simultaneously, we evaluate cell-specific energy flux requirements and their dependence on environmental "extremes". Comparison of metabolic power supply and demand provides a constraint on how biomass abundance varies across a range of environmental parameters, and thereby a prediction of the relative habitability of different environments. We are evaluating the predictive capability of this approach through comparison to observed distributions of microbial abundance in a range of subsurface (predominantly serpentinizing) systems.

  6. On the Active and Passive Flow Separation Control Techniques over Airfoils

    NASA Astrophysics Data System (ADS)

    Moghaddam, Tohid; Banazadeh Neishabouri, Nafiseh

    2017-10-01

    In the present work, recent advances in the field of the active and passive flow separation control, particularly blowing and suction flow control techniques, applied on the common airfoils are briefly reviewed. This broad research area has remained the point of interest for many years as it is applicable to various applications. The suction and blowing flow control methods, among other methods, are more technically feasible and market ready techniques. It is well established that the uniform and/or oscillatory blowing and suction flow control mechanisms significantly improve the lift-to-drag ratio, and further, postpone the boundary layer separation as well as the stall. The oscillatory blowing and suction flow control, however, is more efficient compared to the uniform one. A wide range of parameters is involved in controlling the behavior of a blowing and/or suction flow control, including the location, length, and angle of the jet slots. The oscillation range of the jet slot is another substantial parameter.

  7. Image simulations of quantum dots.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lang, C.; Liao, Xiaozhou; Cockayne, D. J.

    2001-01-01

    Quantum dot (QD) nanostructures have drawn increased interest in recent years. Their small size leads to quantum confinement of the electrons, which is responsible for their unique electronic and optical properties. They promise to find use in a wide range of devices ranging from semiconductor lasers (Bimberg et al (2001), Ribbat et al (2001)) to quantum computing. The properties of QDs are also determined by their shape and composition. All three parameters (size, shape and composition) have a significant impact on their contrast in the transmission electron microscope (TEM), and consequently the possibility arises that these parameters can be extractedmore » from the images. Zone axis plan view images are especially sensitive to the composition of QDs, and image simulation is an important way to understand how the composition determines the contrast. This paper outlines a method of image simulation of QDs developed by Liao et. al. (1999) and presents an application of the method to QDs in wurtzite InN/GaN.« less

  8. Similitude relations for buffet and wing rock on delta wings

    NASA Astrophysics Data System (ADS)

    Mabey, D. G.

    1997-08-01

    Vortex flow phenomena at high angles of incidence are of great interest to the designers of advanced combat aircraft. The steady phenomena (such as steady lift and pitching moments) are understood fairly well, whereas the unsteady phenomena are still uncertain. This paper addresses two important unsteady phenomena on delta wings. With regard to the frequency parameter of the quasi-periodic excitation caused by vortex bursting, a new correlation is established covering a range of sweep back from 60 to 75°. With regard to the much lower frequency parameter of limit-cycle rigid-body wing-rock, a new experiment shows conclusively that although the motion is non-linear, the frequency parameter can be predicted by quasi-steady theory. As a consequence, for a given sweep angle, the frequency parameter is inversely proportional to the square root of the inertia in roll. This is an important observation when attempting to extrapolate from model tests in wind tunnels to predict the wing-rock characteristics of aircraft.

  9. Pseudopotential calculations of AlSb under pressure

    NASA Astrophysics Data System (ADS)

    Algarni, H.; Al-Hagan, O. A.; Bouarissa, N.; Khan, M. A.; Alhuwaymel, T. F.

    2018-02-01

    The dependence on hydrostatic pressure of the electronic and optical properties of zinc-blende AlSb semiconducting material in the pressure range of 0-20 kbar has been reported using a pseudopotential approach. At zero pressure, our findings showed that the electron and heavy hole effective masses are 0.11 and 0.38 m0, respectively. Moreover, our results yielded values of 3.3289 and 11.08 for refractive index and high frequency dielectric constant, respectively. These results are found to be in good accord with experiment. Upon compression, all physical parameters of interest showed a monotonic behavior. The pressure-induced energy shifts for the optical transition related to band-gaps indicated that AlSb remains an indirect (D-X) band-gap semiconductor at pressures from 0 to 20 kbar. The trend in all features of interest versus pressure has been presented and discussed. It is found that the lattice parameter is reduced from 0.61355 to 0.60705 nm when pressure is raised from 0 to 20 kbar. The present investigation may be useful for mid-infrared lasers applications, detectors and communication devices.

  10. System model the processing of heterogeneous sensory information in robotized complex

    NASA Astrophysics Data System (ADS)

    Nikolaev, V.; Titov, V.; Syryamkin, V.

    2018-05-01

    Analyzed the scope and the types of robotic systems consisting of subsystems of the form "a heterogeneous sensors data processing subsystem". On the basis of the Queuing theory model is developed taking into account the unevenness of the intensity of information flow from the sensors to the subsystem of information processing. Analytical solution to assess the relationship of subsystem performance and uneven flows. The research of the obtained solution in the range of parameter values of practical interest.

  11. Forensic case formulation: theoretical, ethical and practical issues.

    PubMed

    Davies, Jason; Black, Susie; Bentley, Natalie; Nagi, Claire

    2013-10-01

    Forensic case formulation, of increasing interest to practitioners and researchers raises many ethical, theoretical and practical issues for them. Systemic, contextual and individual factors which need to be considered include the multitude of staff often involved with any one individual, the pressure to 'get it right' because of the range of risk implications that are associated with individuals within forensic mental health settings, and individual parameters, for example reluctance to be engaged with services. Copyright © 2013 John Wiley & Sons, Ltd.

  12. Multistage Electromagnetic and Laser Launchers for Affordable, Rapid Access to Space

    DTIC Science & Technology

    2011-07-01

    control procedures. To accommodate this, after each gun build, bore gauges were used to accurately measure the bore dimensions , and the projectile...1. Operating Parameters Projectile Mass 5.4 g Bore Dimensions 17 mm × 17 mm Desired Muzzle Speed ~4.5 km/s (3.2m) ~7 km/s (7 m) Gun Length 3.2 m...for a range of ballistic trajectories of interest to the gun launch. The aeroshell dimensions were chosen as being typical for the launch mass

  13. Patchy screening of the cosmic microwave background by inhomogeneous reionization

    NASA Astrophysics Data System (ADS)

    Gluscevic, Vera; Kamionkowski, Marc; Hanson, Duncan

    2013-02-01

    We derive a constraint on patchy screening of the cosmic microwave background from inhomogeneous reionization using off-diagonal TB and TT correlations in WMAP-7 temperature/polarization data. We interpret this as a constraint on the rms optical-depth fluctuation Δτ as a function of a coherence multipole LC. We relate these parameters to a comoving coherence scale, of bubble size RC, in a phenomenological model where reionization is instantaneous but occurs on a crinkly surface, and also to the bubble size in a model of “Swiss cheese” reionization where bubbles of fixed size are spread over some range of redshifts. The current WMAP data are still too weak, by several orders of magnitude, to constrain reasonable models, but forthcoming Planck and future EPIC data should begin to approach interesting regimes of parameter space. We also present constraints on the parameter space imposed by the recent results from the EDGES experiment.

  14. Harmonic and Anharmonic Properties of Diamond Structure Crystals with Application to the Calculation of the Thermal Expansion of Silicon. Ph.D. Thesis. Final Report

    NASA Technical Reports Server (NTRS)

    Wanser, K. H.

    1981-01-01

    Silicon has interesting harmonic and anharmonic properties such as the low lying transverse acoustic modes at the X and L points of the Brillouin zone, negative Gruneisen parameters, negative thermal expansion and anomalous acoustic attenuation. In an attempt to understand these properties, a lattice dynamical model employing long range, nonlocal, dipole-dipole interactions was developed. Analytic expression for the Gruneisen parameters of several modes are presented. These expressions explain how the negative Gruneisen parameters arise. This model is applied to the calculation of the thermal expansion of silicon from 5K to 1700K. The thermoelastic contribution to the acoustic attenuation of silicon is computed from 1 to 300 K. Strong attenuation anomalies associated with negative thermal expansion are found in the vicinity of 17K and 125K.

  15. Effect of growth parameters on the optical properties of ZnO nanostructures grown by simple solution methods

    NASA Astrophysics Data System (ADS)

    Kothari, Anjana

    2017-05-01

    ZnO, a wide band gap semiconductor is of significant interest for a range of practical applications. One of the highly attractive features of ZnO is to grow variety of nanostructures by using low-cost techniques. In this paper, we report deposition of ZnO nanostructure rod-arrays (NRA) via low-temperature, solution-based deposition techniques such as chemical bath deposition (CBD) and microwave-assisted chemical bath deposition (MACBD). A detailed study of film deposition parameters such as variation in concentration of precursors and deposition temperature has been carried out. Compositional and structural study of the films has been done by X-ray Diffractometer to know the phase and purity of the final product. Morphological study of these structures has been carried out by Scanning Electron Microscopy. Optical study such as transmittance and diffuse reflectance of the films has been carried out as a function of growth parameters.

  16. What’s Driving Uncertainty? The Model or the Model Parameters (What’s Driving Uncertainty? The influences of model and model parameters in data analysis)

    DOE PAGES

    Anderson-Cook, Christine Michaela

    2017-03-01

    Here, one of the substantial improvements to the practice of data analysis in recent decades is the change from reporting just a point estimate for a parameter or characteristic, to now including a summary of uncertainty for that estimate. Understanding the precision of the estimate for the quantity of interest provides better understanding of what to expect and how well we are able to predict future behavior from the process. For example, when we report a sample average as an estimate of the population mean, it is good practice to also provide a confidence interval (or credible interval, if youmore » are doing a Bayesian analysis) to accompany that summary. This helps to calibrate what ranges of values are reasonable given the variability observed in the sample and the amount of data that were included in producing the summary.« less

  17. Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII

    PubMed Central

    2012-01-01

    Background Human carbonic anhydrases (CAs) play crucial role in various physiological processes including carbon dioxide and hydrocarbon transport, acid homeostasis, biosynthetic reactions, and various pathological processes, especially tumor progression. Therefore, CAs are interesting targets for pharmaceutical research. The structure-activity relationships (SAR) of designed inhibitors require detailed thermodynamic and structural characterization of the binding reaction. Unfortunately, most publications list only the observed thermodynamic parameters that are significantly different from the intrinsic parameters. However, only intrinsic parameters could be used in the rational design and SAR of the novel compounds. Results Intrinsic binding parameters for several inhibitors, including ethoxzolamide, trifluoromethanesulfonamide, and acetazolamide, binding to recombinant human CA XIII isozyme were determined. The parameters were the intrinsic Gibbs free energy, enthalpy, entropy, and the heat capacity. They were determined by titration calorimetry and thermal shift assay in a wide pH and temperature range to dissect all linked protonation reaction contributions. Conclusions Precise determination of the inhibitor binding thermodynamics enabled correct intrinsic affinity and enthalpy ranking of the compounds and provided the means for SAR analysis of other rationally designed CA inhibitors. PMID:22676044

  18. Probabilistic inference of ecohydrological parameters using observations from point to satellite scales

    NASA Astrophysics Data System (ADS)

    Bassiouni, Maoya; Higgins, Chad W.; Still, Christopher J.; Good, Stephen P.

    2018-06-01

    Vegetation controls on soil moisture dynamics are challenging to measure and translate into scale- and site-specific ecohydrological parameters for simple soil water balance models. We hypothesize that empirical probability density functions (pdfs) of relative soil moisture or soil saturation encode sufficient information to determine these ecohydrological parameters. Further, these parameters can be estimated through inverse modeling of the analytical equation for soil saturation pdfs, derived from the commonly used stochastic soil water balance framework. We developed a generalizable Bayesian inference framework to estimate ecohydrological parameters consistent with empirical soil saturation pdfs derived from observations at point, footprint, and satellite scales. We applied the inference method to four sites with different land cover and climate assuming (i) an annual rainfall pattern and (ii) a wet season rainfall pattern with a dry season of negligible rainfall. The Nash-Sutcliffe efficiencies of the analytical model's fit to soil observations ranged from 0.89 to 0.99. The coefficient of variation of posterior parameter distributions ranged from < 1 to 15 %. The parameter identifiability was not significantly improved in the more complex seasonal model; however, small differences in parameter values indicate that the annual model may have absorbed dry season dynamics. Parameter estimates were most constrained for scales and locations at which soil water dynamics are more sensitive to the fitted ecohydrological parameters of interest. In these cases, model inversion converged more slowly but ultimately provided better goodness of fit and lower uncertainty. Results were robust using as few as 100 daily observations randomly sampled from the full records, demonstrating the advantage of analyzing soil saturation pdfs instead of time series to estimate ecohydrological parameters from sparse records. Our work combines modeling and empirical approaches in ecohydrology and provides a simple framework to obtain scale- and site-specific analytical descriptions of soil moisture dynamics consistent with soil moisture observations.

  19. Analysis of a decision model in the context of equilibrium pricing and order book pricing

    NASA Astrophysics Data System (ADS)

    Wagner, D. C.; Schmitt, T. A.; Schäfer, R.; Guhr, T.; Wolf, D. E.

    2014-12-01

    An agent-based model for financial markets has to incorporate two aspects: decision making and price formation. We introduce a simple decision model and consider its implications in two different pricing schemes. First, we study its parameter dependence within a supply-demand balance setting. We find realistic behavior in a wide parameter range. Second, we embed our decision model in an order book setting. Here, we observe interesting features which are not present in the equilibrium pricing scheme. In particular, we find a nontrivial behavior of the order book volumes which reminds of a trend switching phenomenon. Thus, the decision making model alone does not realistically represent the trading and the stylized facts. The order book mechanism is crucial.

  20. Noise reduction of a composite cylinder subjected to random acoustic excitation

    NASA Technical Reports Server (NTRS)

    Grosveld, Ferdinand W.; Beyer, T.

    1989-01-01

    Interior and exterior noise measurements were conducted on a stiffened composite floor-equipped cylinder, with and without an interior trim installed. Noise reduction was obtained for the case of random acoustic excitation in a diffuse field; the frequency range of interest was 100-800-Hz one-third octave bands. The measured data were compared with noise reduction predictions from the Propeller Aircraft Interior Noise (PAIN) program and from a statistical energy analysis. Structural model parameters were not predicted well by the PAIN program for the given input parameters; this resulted in incorrect noise reduction predictions for the lower one-third octave bands where the power flow into the interior of the cylinder was predicted on a mode-per-mode basis.

  1. OBSERVED ASTEROID SURFACE AREA IN THE THERMAL INFRARED

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nugent, C. R.; Mainzer, A.; Masiero, J.

    The rapid accumulation of thermal infrared observations and shape models of asteroids has led to increased interest in thermophysical modeling. Most of these infrared observations are unresolved. We consider what fraction of an asteroid’s surface area contributes the bulk of the emitted thermal flux for two model asteroids of different shapes over a range of thermal parameters. The resulting observed surface in the infrared is generally more fragmented than the area observed in visible wavelengths, indicating high sensitivity to shape. For objects with low values of the thermal parameter, small fractions of the surface contribute the majority of thermally emittedmore » flux. Calculating observed areas could enable the production of spatially resolved thermal inertia maps from non-resolved observations of asteroids.« less

  2. Uncertainty Quantification for Polynomial Systems via Bernstein Expansions

    NASA Technical Reports Server (NTRS)

    Crespo, Luis G.; Kenny, Sean P.; Giesy, Daniel P.

    2012-01-01

    This paper presents a unifying framework to uncertainty quantification for systems having polynomial response metrics that depend on both aleatory and epistemic uncertainties. The approach proposed, which is based on the Bernstein expansions of polynomials, enables bounding the range of moments and failure probabilities of response metrics as well as finding supersets of the extreme epistemic realizations where the limits of such ranges occur. These bounds and supersets, whose analytical structure renders them free of approximation error, can be made arbitrarily tight with additional computational effort. Furthermore, this framework enables determining the importance of particular uncertain parameters according to the extent to which they affect the first two moments of response metrics and failure probabilities. This analysis enables determining the parameters that should be considered uncertain as well as those that can be assumed to be constants without incurring significant error. The analytical nature of the approach eliminates the numerical error that characterizes the sampling-based techniques commonly used to propagate aleatory uncertainties as well as the possibility of under predicting the range of the statistic of interest that may result from searching for the best- and worstcase epistemic values via nonlinear optimization or sampling.

  3. Estimation of intra-operator variability in perfusion parameter measurements using DCE-US

    PubMed Central

    Gauthier, Marianne; Leguerney, Ingrid; Thalmensi, Jessie; Chebil, Mohamed; Parisot, Sarah; Peronneau, Pierre; Roche, Alain; Lassau, Nathalie

    2011-01-01

    AIM: To investigate intra-operator variability of semi-quantitative perfusion parameters using dynamic contrast-enhanced ultrasonography (DCE-US), following bolus injections of SonoVue®. METHODS: The in vitro experiments were conducted using three in-house sets up based on pumping a fluid through a phantom placed in a water tank. In the in vivo experiments, B16F10 melanoma cells were xenografted to five nude mice. Both in vitro and in vivo, images were acquired following bolus injections of the ultrasound contrast agent SonoVue® (Bracco, Milan, Italy) and using a Toshiba Aplio® ultrasound scanner connected to a 2.9-5.8 MHz linear transducer (PZT, PLT 604AT probe) (Toshiba, Japan) allowing harmonic imaging (“Vascular Recognition Imaging”) involving linear raw data. A mathematical model based on the dye-dilution theory was developed by the Gustave Roussy Institute, Villejuif, France and used to evaluate seven perfusion parameters from time-intensity curves. Intra-operator variability analyses were based on determining perfusion parameter coefficients of variation (CV). RESULTS: In vitro, different volumes of SonoVue® were tested with the three phantoms: intra-operator variability was found to range from 2.33% to 23.72%. In vivo, experiments were performed on tumor tissues and perfusion parameters exhibited values ranging from 1.48% to 29.97%. In addition, the area under the curve (AUC) and the area under the wash-out (AUWO) were two of the parameters of great interest since throughout in vitro and in vivo experiments their variability was lower than 15.79%. CONCLUSION: AUC and AUWO appear to be the most reliable parameters for assessing tumor perfusion using DCE-US as they exhibited the lowest CV values. PMID:21512654

  4. Estimation of intra-operator variability in perfusion parameter measurements using DCE-US.

    PubMed

    Gauthier, Marianne; Leguerney, Ingrid; Thalmensi, Jessie; Chebil, Mohamed; Parisot, Sarah; Peronneau, Pierre; Roche, Alain; Lassau, Nathalie

    2011-03-28

    To investigate intra-operator variability of semi-quantitative perfusion parameters using dynamic contrast-enhanced ultrasonography (DCE-US), following bolus injections of SonoVue(®). The in vitro experiments were conducted using three in-house sets up based on pumping a fluid through a phantom placed in a water tank. In the in vivo experiments, B16F10 melanoma cells were xenografted to five nude mice. Both in vitro and in vivo, images were acquired following bolus injections of the ultrasound contrast agent SonoVue(®) (Bracco, Milan, Italy) and using a Toshiba Aplio(®) ultrasound scanner connected to a 2.9-5.8 MHz linear transducer (PZT, PLT 604AT probe) (Toshiba, Japan) allowing harmonic imaging ("Vascular Recognition Imaging") involving linear raw data. A mathematical model based on the dye-dilution theory was developed by the Gustave Roussy Institute, Villejuif, France and used to evaluate seven perfusion parameters from time-intensity curves. Intra-operator variability analyses were based on determining perfusion parameter coefficients of variation (CV). In vitro, different volumes of SonoVue(®) were tested with the three phantoms: intra-operator variability was found to range from 2.33% to 23.72%. In vivo, experiments were performed on tumor tissues and perfusion parameters exhibited values ranging from 1.48% to 29.97%. In addition, the area under the curve (AUC) and the area under the wash-out (AUWO) were two of the parameters of great interest since throughout in vitro and in vivo experiments their variability was lower than 15.79%. AUC and AUWO appear to be the most reliable parameters for assessing tumor perfusion using DCE-US as they exhibited the lowest CV values.

  5. Polysoaps: Configurations and Elasticity

    NASA Astrophysics Data System (ADS)

    Halperin, A.

    1997-03-01

    Simple polymers are very long, flexible, linear molecules. Amphiphiles, soaps, are small molecules comprising of a part that prefers water over oil and a part that prefers oil over water. By combining the two we arrive at an interesting, little explored, class of materials: Polysoaps. These comprise of a water soluble backbone incorporating, at intervals, covalently bound amphiphilic monomers. In water, the polymerised amphiphiles aggregate into self assembled units known as micelles. This induces a dramatic modification of the spatial configurations of the polymers. What were featureless random coils now exhibit intramolecular, hierachial self organisation. Due to this self organisation it is necessary to modify the paradigms describing the large scale behaviour of these polymers: Their configurations, dimensions and elasticity. Understanding the behaviour of these polymers is of practical interest because of their wide range of industrial applications, ranging from cosmetics to paper coating. It is of fundamental interest because polysoaps are characterised by a rugged free energy landscape that is reminiscent of complex systems such as proteins and glasses. The talk concerns theoretical arguments regarding the following issues: (i) The design parameters that govern the spatial configurations of the polysoaps, (ii) The interaction between polysoaps and free amphiphiles, (iii) The effect of the intramolecular self organisation on the elasticity of the chains.

  6. Structure, magnetism and electronic properties in 3d-5d based double perovskite ({Sr_{1-x}} Y x )2FeIrO6

    NASA Astrophysics Data System (ADS)

    Kharkwal, K. C.; Pramanik, A. K.

    2017-12-01

    The 3d-5d based double perovskites are of current interest as they provide model systems to study the interplay between electronic correlation (U) and spin-orbit coupling (SOC). Here, we report detailed structural, magnetic and transport properties of doped double perovskite material (Sr1-x Y x )2FeIrO6 with x ≤slant 0.2 . With substitution of Y, the system retains its original crystal structure but structural parameters change with x in nonmonotonic fashion. The magnetization data for Sr2FeIrO6 show antiferromagnetic type magnetic transition around 45 K however, a close inspection of the data indicates a weak magnetic phase transition around 120 K. No change of structural symmetry has been observed down to low temperature, although the lattice parameters show sudden changes around the magnetic transitions. Sr2FeIrO6 shows an insulating behavior over the whole temperature range, which nevertheless does not change with Y substitution. The nature of charge conduction is found to follow thermally activated Mott’s variable range hopping and power law behavior for parent and doped samples, respectively. Interestingly, evolution of structural, magnetic and transport behavior in (Sr1-x Y x )2FeIrO6 is observed to reverse with x > 0.1 , which is believed to arise due to a change in the transition metal ionic state.

  7. Structure, magnetism and electronic properties in 3d-5d based double perovskite ([Formula: see text]Y x )2FeIrO6.

    PubMed

    Kharkwal, K C; Pramanik, A K

    2017-11-13

    The 3d-5d based double perovskites are of current interest as they provide model systems to study the interplay between electronic correlation (U) and spin-orbit coupling (SOC). Here, we report detailed structural, magnetic and transport properties of doped double perovskite material ([Formula: see text]Y x ) 2 FeIrO 6 with [Formula: see text]. With substitution of Y, the system retains its original crystal structure but structural parameters change with x in nonmonotonic fashion. The magnetization data for Sr 2 FeIrO 6 show antiferromagnetic type magnetic transition around 45 K; however, a close inspection of the data indicates a weak magnetic phase transition around 120 K. No change of structural symmetry has been observed down to low temperature, although the lattice parameters show sudden changes around the magnetic transitions. Sr 2 FeIrO 6 shows an insulating behavior over the whole temperature range, which nevertheless does not change with Y substitution. The nature of charge conduction is found to follow thermally activated Mott's variable range hopping and power law behavior for parent and doped samples, respectively. Interestingly, evolution of structural, magnetic and transport behavior in ([Formula: see text]Y x ) 2 FeIrO 6 is observed to reverse with [Formula: see text], which is believed to arise due to a change in the transition metal ionic state.

  8. Scattering cross section of mesospheric echoes and turbulence parameters from Gadanki radar observations

    NASA Astrophysics Data System (ADS)

    Selvaraj, D.; Patra, A. K.; Chandra, H.; Sinha, H. S. S.; Das, U.

    2014-11-01

    We present a comprehensive study on radar scattering cross section of mesospheric echoes and mesospheric turbulence parameters based on several days of observations made during two rocket-radar campaigns, one in July 2004 and another in April 2005, meant for studying mesospheric turbulence. Radar scattering cross section was found to have large local time and day-to-day variability and was found to be as low as 3.1×10-18 m-1 and as high as 1×10-14 m-1 and the median values were in the range of 4.4×10-18-4.7×10-16 m-1. Echoes connected with the low value of scattering cross section could be detected only when a long pulse width was used. Turbulence parameters were found to vary remarkably with time of the day and also from one day to another. In July, the turbulent kinetic energy (TKE) dissipation rate, outer scale and inner scale were in the range of 0.08-150 mW/kg, 33-1500 m, and 1.9-50 m, respectively, and their median values were in the range of 5-52 mW/kg, 293-977 m, and 2-31 m, respectively. In April, these estimates were in the range of 0.9-69 mW/kg, 38-1081 m, and 4-21 m, respectively, and their median values were in the range of 1-12 mW/kg, 140-378 m, and 8-13 m, respectively. These parameters are found to agree quite well with those estimated from rocket-borne observations, which were in the range of 4-117 mW/kg, 220-1475 m, and 15-31 m, respectively, in July and 2-36 mW/kg, 170-680 m, and 17-37 m, respectively, in April. Interestingly, the inner and outer scales estimated using both radar and rocket observations agree exceedingly well with model values. These results are compared in detail with those reported from low, middle and high latitudes including model and discussed in the light of current knowledge of mesospheric turbulence.

  9. Association of parameter, software, and hardware variation with large-scale behavior across 57,000 climate models

    PubMed Central

    Knight, Christopher G.; Knight, Sylvia H. E.; Massey, Neil; Aina, Tolu; Christensen, Carl; Frame, Dave J.; Kettleborough, Jamie A.; Martin, Andrew; Pascoe, Stephen; Sanderson, Ben; Stainforth, David A.; Allen, Myles R.

    2007-01-01

    In complex spatial models, as used to predict the climate response to greenhouse gas emissions, parameter variation within plausible bounds has major effects on model behavior of interest. Here, we present an unprecedentedly large ensemble of >57,000 climate model runs in which 10 parameters, initial conditions, hardware, and software used to run the model all have been varied. We relate information about the model runs to large-scale model behavior (equilibrium sensitivity of global mean temperature to a doubling of carbon dioxide). We demonstrate that effects of parameter, hardware, and software variation are detectable, complex, and interacting. However, we find most of the effects of parameter variation are caused by a small subset of parameters. Notably, the entrainment coefficient in clouds is associated with 30% of the variation seen in climate sensitivity, although both low and high values can give high climate sensitivity. We demonstrate that the effect of hardware and software is small relative to the effect of parameter variation and, over the wide range of systems tested, may be treated as equivalent to that caused by changes in initial conditions. We discuss the significance of these results in relation to the design and interpretation of climate modeling experiments and large-scale modeling more generally. PMID:17640921

  10. Subnanosecond breakdown in high-pressure gases

    NASA Astrophysics Data System (ADS)

    Naidis, George V.; Tarasenko, Victor F.; Babaeva, Natalia Yu; Lomaev, Mikhail I.

    2018-01-01

    Pulsed discharges in high-pressure gases are of considerable interest as sources of nonequilibrium plasma for various technological applications: pollution control, pumping of laser media, plasma-assisted combustion, etc. Recently, attention has been attracted to the use of subnanosecond voltage fronts, producing diffuse discharges with radii of several millimeters. Such plasma structures, similar to pulsed glow discharges, are of special interest for applications due to quasi-uniformity of plasma parameters in relatively large gas volumes. This review presents the results of experimental and computational study of subnanosecond diffuse discharge formation. A description of generators of short high-voltage pulses with subnanosecond fronts and of discharge setups is given. Diagnostic methods for the measurement of various discharge parameters with high temporal and spatial resolution are described. Obtained experimental data on plasma properties for a wide range of governing factors are discussed. A review of various theoretical approaches used for computational study of the dynamics and structure of fast ionization waves is given; the applicability of conventional fluid streamer models for simulation of subnanosecond ionization waves is discussed. Calculated spatial-temporal profiles of plasma parameters during streamer propagation are presented. The efficiency of subnanosecond discharges for the production of reactive species is evaluated. On the basis of the comparison of simulation results and experimental data the effects of various factors (voltage rise time, polarity, etc.) on discharge characteristics are revealed. The major physical phenomena governing the properties of subnanosecond breakdown are analyzed.

  11. Performance evaluation of a hybrid-passive landfill leachate treatment system using multivariate statistical techniques

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wallace, Jack, E-mail: jack.wallace@ce.queensu.ca; Champagne, Pascale, E-mail: champagne@civil.queensu.ca; Monnier, Anne-Charlotte, E-mail: anne-charlotte.monnier@insa-lyon.fr

    Highlights: • Performance of a hybrid passive landfill leachate treatment system was evaluated. • 33 Water chemistry parameters were sampled for 21 months and statistically analyzed. • Parameters were strongly linked and explained most (>40%) of the variation in data. • Alkalinity, ammonia, COD, heavy metals, and iron were criteria for performance. • Eight other parameters were key in modeling system dynamics and criteria. - Abstract: A pilot-scale hybrid-passive treatment system operated at the Merrick Landfill in North Bay, Ontario, Canada, treats municipal landfill leachate and provides for subsequent natural attenuation. Collected leachate is directed to a hybrid-passive treatment system,more » followed by controlled release to a natural attenuation zone before entering the nearby Little Sturgeon River. The study presents a comprehensive evaluation of the performance of the system using multivariate statistical techniques to determine the interactions between parameters, major pollutants in the leachate, and the biological and chemical processes occurring in the system. Five parameters (ammonia, alkalinity, chemical oxygen demand (COD), “heavy” metals of interest, with atomic weights above calcium, and iron) were set as criteria for the evaluation of system performance based on their toxicity to aquatic ecosystems and importance in treatment with respect to discharge regulations. System data for a full range of water quality parameters over a 21-month period were analyzed using principal components analysis (PCA), as well as principal components (PC) and partial least squares (PLS) regressions. PCA indicated a high degree of association for most parameters with the first PC, which explained a high percentage (>40%) of the variation in the data, suggesting strong statistical relationships among most of the parameters in the system. Regression analyses identified 8 parameters (set as independent variables) that were most frequently retained for modeling the five criteria parameters (set as dependent variables), on a statistically significant level: conductivity, dissolved oxygen (DO), nitrite (NO{sub 2}{sup −}), organic nitrogen (N), oxidation reduction potential (ORP), pH, sulfate and total volatile solids (TVS). The criteria parameters and the significant explanatory parameters were most important in modeling the dynamics of the passive treatment system during the study period. Such techniques and procedures were found to be highly valuable and could be applied to other sites to determine parameters of interest in similar naturalized engineered systems.« less

  12. An IT-enabled supply chain model: a simulation study

    NASA Astrophysics Data System (ADS)

    Cannella, Salvatore; Framinan, Jose M.; Barbosa-Póvoa, Ana

    2014-11-01

    During the last decades, supply chain collaboration practices and the underlying enabling technologies have evolved from the classical electronic data interchange (EDI) approach to a web-based and radio frequency identification (RFID)-enabled collaboration. In this field, most of the literature has focused on the study of optimal parameters for reducing the total cost of suppliers, by adopting operational research (OR) techniques. Herein we are interested in showing that the considered information technology (IT)-enabled structure is resilient, that is, it works well across a reasonably broad range of parameter settings. By adopting a methodological approach based on system dynamics, we study a multi-tier collaborative supply chain. Results show that the IT-enabled supply chain improves operational performance and customer service level. Nonetheless, benefits for geographically dispersed networks are of minor entity.

  13. Holography and the Coleman-Mermin-Wagner theorem

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anninos, Dionysios; Hartnoll, Sean A.; Iqbal, Nabil

    2010-09-15

    In 2+1 dimensions at finite temperature, spontaneous symmetry breaking of global symmetries is precluded by large thermal fluctuations of the order parameter. The holographic correspondence implies that analogous effects must also occur in 3+1 dimensional theories with gauged symmetries in certain curved spacetimes with horizon. By performing a one loop computation in the background of a holographic superconductor, we show that bulk quantum fluctuations wash out the classical order parameter at sufficiently large distance scales. The low temperature phase is seen to exhibit algebraic long-range order. Beyond the specific example we study, holography suggests that IR singular quantum fluctuations ofmore » the fields and geometry will play an interesting role for many 3+1 dimensional asymptotically anti-de Sitter spacetimes with planar horizon.« less

  14. Evolution of the squeezing-enhanced vacuum state in the amplitude dissipative channel

    NASA Astrophysics Data System (ADS)

    Ren, Gang; Du, Jian-ming; Zhang, Wen-hai

    2018-05-01

    We study the evolution of the squeezing-enhanced vacuum state (SEVS) in the amplitude dissipative channel by using the two-mode entangled state in the Fock space and Kraus operator. The explicit formulation of the output state is also given. It is found that the output state does not exhibit sub-Poissonian behavior for the nonnegative value of the Mandel's Q-parameters in a wide range of values of squeezing parameter and dissipation factor. It is interesting to see that second-order correlation function is independent of the dissipation factor. However, the photon-number distribution of the output quantum state shows remarkable oscillations with respect to the dissipation factor. The shape of Wigner function and the degree of squeezing show that the initial SEVS is dissipated by the amplitude dissipative channel.

  15. A Toolkit to Study Sensitivity of the Geant4 Predictions to the Variations of the Physics Model Parameters

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fields, Laura; Genser, Krzysztof; Hatcher, Robert

    Geant4 is the leading detector simulation toolkit used in high energy physics to design detectors and to optimize calibration and reconstruction software. It employs a set of carefully validated physics models to simulate interactions of particles with matter across a wide range of interaction energies. These models, especially the hadronic ones, rely largely on directly measured cross-sections and phenomenological predictions with physically motivated parameters estimated by theoretical calculation or measurement. Because these models are tuned to cover a very wide range of possible simulation tasks, they may not always be optimized for a given process or a given material. Thismore » raises several critical questions, e.g. how sensitive Geant4 predictions are to the variations of the model parameters, or what uncertainties are associated with a particular tune of a Geant4 physics model, or a group of models, or how to consistently derive guidance for Geant4 model development and improvement from a wide range of available experimental data. We have designed and implemented a comprehensive, modular, user-friendly software toolkit to study and address such questions. It allows one to easily modify parameters of one or several Geant4 physics models involved in the simulation, and to perform collective analysis of multiple variants of the resulting physics observables of interest and comparison against a variety of corresponding experimental data. Based on modern event-processing infrastructure software, the toolkit offers a variety of attractive features, e.g. flexible run-time configurable workflow, comprehensive bookkeeping, easy to expand collection of analytical components. Design, implementation technology, and key functionalities of the toolkit are presented and illustrated with results obtained with Geant4 key hadronic models.« less

  16. C-metric solution for conformal gravity with a conformally coupled scalar field

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meng, Kun, E-mail: mengkun@tjpu.edu.cn; Zhao, Liu, E-mail: lzhao@nankai.edu.cn

    The C-metric solution of conformal gravity with a conformally coupled scalar field is presented. The solution belongs to the class of Petrov type D spacetimes and is conformal to the standard AdS C-metric appeared in vacuum Einstein gravity. For all parameter ranges, we identify some of the physically interesting static regions and the corresponding coordinate ranges. The solution may contain a black hole event horizon, an acceleration horizon, either of which may be cut by the conformal infinity or be hidden behind the conformal infinity. Since the model is conformally invariant, we also discussed the possible effects of the conformalmore » gauge choices on the structure of the spacetime.« less

  17. A Probabilistic Approach to Predict Thermal Fatigue Life for Ball Grid Array Solder Joints

    NASA Astrophysics Data System (ADS)

    Wei, Helin; Wang, Kuisheng

    2011-11-01

    Numerous studies of the reliability of solder joints have been performed. Most life prediction models are limited to a deterministic approach. However, manufacturing induces uncertainty in the geometry parameters of solder joints, and the environmental temperature varies widely due to end-user diversity, creating uncertainties in the reliability of solder joints. In this study, a methodology for accounting for variation in the lifetime prediction for lead-free solder joints of ball grid array packages (PBGA) is demonstrated. The key aspects of the solder joint parameters and the cyclic temperature range related to reliability are involved. Probabilistic solutions of the inelastic strain range and thermal fatigue life based on the Engelmaier model are developed to determine the probability of solder joint failure. The results indicate that the standard deviation increases significantly when more random variations are involved. Using the probabilistic method, the influence of each variable on the thermal fatigue life is quantified. This information can be used to optimize product design and process validation acceptance criteria. The probabilistic approach creates the opportunity to identify the root causes of failed samples from product fatigue tests and field returns. The method can be applied to better understand how variation affects parameters of interest in an electronic package design with area array interconnections.

  18. Experimental Results of Site Calibration and Sensitivity Measurements in OTR for UWB Systems

    NASA Astrophysics Data System (ADS)

    Viswanadham, Chandana; Rao, P. Mallikrajuna

    2017-06-01

    System calibration and parameter accuracy measurement of electronic support measures (ESM) systems is a major activity, carried out by electronic warfare (EW) engineers. These activities are very critical and needs good understanding in the field of microwaves, antennas, wave propagation, digital and communication domains. EW systems are broad band, built with state-of-the art electronic hardware, installed on different varieties of military platforms to guard country's security from time to time. EW systems operate in wide frequency ranges, typically in the order of thousands of MHz, hence these are ultra wide band (UWB) systems. Few calibration activities are carried within the system and in the test sites, to meet the accuracies of final specifications. After calibration, parameters are measured for their accuracies either in feed mode by injecting the RF signals into the front end or in radiation mode by transmitting the RF signals on to system antenna. To carry out these activities in radiation mode, a calibrated open test range (OTR) is necessary in the frequency band of interest. Thus site calibration of OTR is necessary to be carried out before taking up system calibration and parameter measurements. This paper presents the experimental results of OTR site calibration and sensitivity measurements of UWB systems in radiation mode.

  19. Improved excitation rate coefficients for the n = 2 and n = 3 levels of Ca XIX and Fe XXV including fine structure

    NASA Technical Reports Server (NTRS)

    Pradhan, A. K.

    1985-01-01

    Reently calculated collision strengths, including relativistic and resonance effects, are employed to compute Maxwellian averaged collision strengths for 78 transitions involving states of principal quantum numbers 2-1 and 3-1 in Ca XIX and Fe XXV. These rate parameters are tabulated at temperatures of interest in astrophysical and labortory plasmas with radiation in the hard X-ray wavelength range. For some transitions, significant differences are found with the earlier calculations of Pradhan, Norcross, and Hummer (1981).

  20. Analytical modeling of the structureborne noise path on a small twin-engine aircraft

    NASA Technical Reports Server (NTRS)

    Cole, J. E., III; Stokes, A. Westagard; Garrelick, J. M.; Martini, K. F.

    1988-01-01

    The structureborne noise path of a six passenger twin-engine aircraft is analyzed. Models of the wing and fuselage structures as well as the interior acoustic space of the cabin are developed and used to evaluate sensitivity to structural and acoustic parameters. Different modeling approaches are used to examine aspects of the structureborne path. These approaches are guided by a number of considerations including the geometry of the structures, the frequency range of interest, and the tractability of the computations. Results of these approaches are compared with experimental data.

  1. Localized spoof surface plasmon resonances at terahertz range

    NASA Astrophysics Data System (ADS)

    Chen, Lin; Xu, Mengjian; Zang, Xiaofei; Peng, Yan; Zhu, Yiming

    2016-11-01

    The influence of the inner disk radius r, the filling ratio α, numbers of sectors N, and the gap g on transmission response for corrugated metallic disk (CMD) with single C-shaped resonator(CSR) has been fully studied. The results indicate that varying parameters r can efficiently excite the higher order spoof localized surface plasmon modes in corrugated metallic disk. The relationship between the bright dipole and dark multipolar resonances presents the possibility of high Q dark resonances excitation. All results may be of great interest for diverse applications.

  2. Experimental test results of a generalized parameter fuel control

    NASA Technical Reports Server (NTRS)

    Batterton, P. G.; Gold, H.

    1973-01-01

    Considerable interest has been generated recently in low cost jet propulsion systems. One of the more complicated components of jet engines is the fuel control. Results of an effort to develop a simpler hydromechanical fuel control are presented. This prototype fuel control was installed on a J85-GE-13 jet engine. Results show that the fuel control provided satisfactory engine performance at sea level static conditions over its normal nonafterburning operating range, including startup. Results of both bench and engine tests are presented; the difficulties encountered are described.

  3. Numerical Modeling in Problems of Near-Earth Object Dynamics

    NASA Astrophysics Data System (ADS)

    Aleksandrova, A. G.; Bordovitsyna, T. V.; Chuvashov, I. N.

    2017-05-01

    A method of numerical modeling is used to solve three most interesting problems of artificial Earth satellite (AES) dynamics. Orbital evolution of an ensemble of near-Earth objects at altitudes in the range from 1 500 to 60 000 km is considered, chaoticity of motion of objects in the geosynchronous zone is studied by the MEGNOanalysis, the parameters of AES motion are determined, and the models of forces are considered from measurements for GLONASS satellites. The recent versions of algorithms and programs used to perform investigations are briefly described.

  4. Modeled Neutron Induced Nuclear Reaction Cross Sections for Radiochemsitry in the region of Thulium, Lutetium, and Tantalum I. Results of Built in Spherical Symmetry in a Deformed Region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hoffman, R. D.

    2013-09-06

    We have developed a set of modeled nuclear reaction cross sections for use in radiochemical diagnostics. Systematics for the input parameters required by the Hauser-Feshbach statistical model were developed and used to calculate neutron induced nuclear reaction cross sections for targets ranging from Terbium (Z = 65) to Rhenium (Z = 75). Of particular interest are the cross sections on Tm, Lu, and Ta including reactions on isomeric targets.

  5. A GPS coverage model

    NASA Technical Reports Server (NTRS)

    Skidmore, Trent A.

    1994-01-01

    The results of several case studies using the Global Positioning System coverage model developed at Ohio University are summarized. Presented are results pertaining to outage area, outage dynamics, and availability. Input parameters to the model include the satellite orbit data, service area of interest, geometry requirements, and horizon and antenna mask angles. It is shown for precision-landing Category 1 requirements that the planned GPS 21 Primary Satellite Constellation produces significant outage area and unavailability. It is also shown that a decrease in the user equivalent range error dramatically decreases outage area and improves the service availability.

  6. Taguchi Optimization of Cutting Parameters in Turning AISI 1020 MS with M2 HSS Tool

    NASA Astrophysics Data System (ADS)

    Sonowal, Dharindom; Sarma, Dhrupad; Bakul Barua, Parimal; Nath, Thuleswar

    2017-08-01

    In this paper the effect of three cutting parameters viz. Spindle speed, Feed and Depth of Cut on surface roughness of AISI 1020 mild steel bar in turning was investigated and optimized to obtain minimum surface roughness. All the experiments are conducted on HMT LB25 lathe machine using M2 HSS cutting tool. Ranges of parameters of interest have been decided through some preliminary experimentation (One Factor At a Time experiments). Finally a combined experiment has been carried out using Taguchi’s L27 Orthogonal Array (OA) to study the main effect and interaction effect of the all three parameters. The experimental results were analyzed with raw data ANOVA (Analysis of Variance) and S/N data (Signal to Noise ratio) ANOVA. Results show that Spindle speed, Feed and Depth of Cut have significant effects on both mean and variation of surface roughness in turning AISI 1020 mild steel. Mild two factors interactions are observed among the aforesaid factors with significant effects only on the mean of the output variable. From the Taguchi parameter optimization the optimum factor combination is found to be 630 rpm spindle speed, 0.05 mm/rev feed and 1.25 mm depth of cut with estimated surface roughness 2.358 ± 0.970 µm. A confirmatory experiment was conducted with the optimum factor combination to verify the results. In the confirmatory experiment the average value of surface roughness is found to be 2.408 µm which is well within the range (0.418 µm to 4.299 µm) predicted for confirmatory experiment.

  7. Integration of Ground, Buoys, Satellite and Model data to map the Changes in Meteorological Parameters Associated with Harvey Hurricane

    NASA Astrophysics Data System (ADS)

    Chauhan, A.; Sarkar, S.; Singh, R. P.

    2017-12-01

    The coastal areas have dense onshore and marine observation network and are also routinely monitored by constellation of satellites. The monitoring of ocean, land and atmosphere through a range of meteorological parameters, provides information about the land and ocean surface. Satellite data also provide information at different pressure levels that help to access the development of tropical storms and formation of hurricanes at different categories. Integration of ground, buoys, satellite and model data showing the changes in meteorological parameters during the landfall stages of hurricane Harvey will be discussed. Hurricane Harvey was one of the deadliest hurricanes at the Gulf coast which caused intense flooding from the precipitation. The various observation networks helped city administrators to evacuate the coastal areas, that minimized the loss of lives compared to the Galveston hurricane of 1900 which took 10,000 lives. Comparison of meteorological parameters derived from buoys, ground stations and satellites associated with Harvey and 2005 Katrina hurricane present some of the interesting features of the two hurricanes.

  8. Spatial design and strength of spatial signal: Effects on covariance estimation

    USGS Publications Warehouse

    Irvine, Kathryn M.; Gitelman, Alix I.; Hoeting, Jennifer A.

    2007-01-01

    In a spatial regression context, scientists are often interested in a physical interpretation of components of the parametric covariance function. For example, spatial covariance parameter estimates in ecological settings have been interpreted to describe spatial heterogeneity or “patchiness” in a landscape that cannot be explained by measured covariates. In this article, we investigate the influence of the strength of spatial dependence on maximum likelihood (ML) and restricted maximum likelihood (REML) estimates of covariance parameters in an exponential-with-nugget model, and we also examine these influences under different sampling designs—specifically, lattice designs and more realistic random and cluster designs—at differing intensities of sampling (n=144 and 361). We find that neither ML nor REML estimates perform well when the range parameter and/or the nugget-to-sill ratio is large—ML tends to underestimate the autocorrelation function and REML produces highly variable estimates of the autocorrelation function. The best estimates of both the covariance parameters and the autocorrelation function come under the cluster sampling design and large sample sizes. As a motivating example, we consider a spatial model for stream sulfate concentration.

  9. Revisiting gamma-ray burst afterglows with time-dependent parameters

    NASA Astrophysics Data System (ADS)

    Yang, Chao; Zou, Yuan-Chuan; Chen, Wei; Liao, Bin; Lei, Wei-Hua; Liu, Yu

    2018-02-01

    The relativistic external shock model of gamma-ray burst (GRB) afterglows has been established with five free parameters, i.e., the total kinetic energy E, the equipartition parameters for electrons {{ε }}{{e}} and for the magnetic field {{ε }}{{B}}, the number density of the environment n and the index of the power-law distribution of shocked electrons p. A lot of modified models have been constructed to consider the variety of GRB afterglows, such as: the wind medium environment by letting n change with radius, the energy injection model by letting kinetic energy change with time and so on. In this paper, by assuming all four parameters (except p) change with time, we obtain a set of formulas for the dynamics and radiation, which can be used as a reference for modeling GRB afterglows. Some interesting results are obtained. For example, in some spectral segments, the radiated flux density does not depend on the number density or the profile of the environment. As an application, through modeling the afterglow of GRB 060607A, we find that it can be interpreted in the framework of the time dependent parameter model within a reasonable range.

  10. A Methodology for Robust Comparative Life Cycle Assessments Incorporating Uncertainty.

    PubMed

    Gregory, Jeremy R; Noshadravan, Arash; Olivetti, Elsa A; Kirchain, Randolph E

    2016-06-21

    We propose a methodology for conducting robust comparative life cycle assessments (LCA) by leveraging uncertainty. The method evaluates a broad range of the possible scenario space in a probabilistic fashion while simultaneously considering uncertainty in input data. The method is intended to ascertain which scenarios have a definitive environmentally preferable choice among the alternatives being compared and the significance of the differences given uncertainty in the parameters, which parameters have the most influence on this difference, and how we can identify the resolvable scenarios (where one alternative in the comparison has a clearly lower environmental impact). This is accomplished via an aggregated probabilistic scenario-aware analysis, followed by an assessment of which scenarios have resolvable alternatives. Decision-tree partitioning algorithms are used to isolate meaningful scenario groups. In instances where the alternatives cannot be resolved for scenarios of interest, influential parameters are identified using sensitivity analysis. If those parameters can be refined, the process can be iterated using the refined parameters. We also present definitions of uncertainty quantities that have not been applied in the field of LCA and approaches for characterizing uncertainty in those quantities. We then demonstrate the methodology through a case study of pavements.

  11. Oscillatory flow past a slip cylindrical inclusion embedded in a Brinkman medium

    NASA Astrophysics Data System (ADS)

    Palaniappan, D.

    2015-11-01

    Transient flow past a circular cylinder embedded in a porous medium is studied based on Brinkman model with Navier slip conditions. Closed form analytic solution for the stream-function describing slow oscillatory flow around a solid cylindrical inclusion is obtained in the limit of low-Reynolds-number. The key parameters such as the frequency of oscillation λ, the permeability constant δ, and the slip coefficient ξ dictate the flow fields and physical quantities in the entire flow domain. Asymptotic steady-state analysis when δ --> 0 reveals the paradoxical behavior detected by Stokes. Local streamlines for small times demonstrate interesting flow patterns. Rapid transitions including flow separations and eddies are observed far away from the solid inclusion. Analytic expressions for the wall shear stress and the force acting on the cylinder are computed and compared with existing results. It is noted that the slip parameter in the range 0 <= ξ <= 0 . 5 has a significant effect in reducing the stress and force. In the limit of large permeability, Darcy (potential) flow is recovered outside a boundary layer. The results are of some interest in predicting maximum wall stress and pressure drop associated with biological models in fibrous media.

  12. Acousto-ultrasonics to Assess Material and Structural Properties

    NASA Technical Reports Server (NTRS)

    Kautz, Harold E.

    2002-01-01

    This report was created to serve as a manual for applying the Acousto-Ultrasonic NDE method, as practiced at NASA Glenn, to the study of materials and structures for a wide range of applications. Three state of the art acousto-ultrasonic (A-U) analysis parameters, ultrasonic decay (UD) rate, mean time (or skewing factor, "s"), and the centroid of the power spectrum, "f(sub c)," have been studied and applied at GRC for NDE interrogation of various materials and structures of aerospace interest. In addition to this, a unique application of Lamb wave analysis is shown. An appendix gives a brief overview of Lamb Wave analysis. This paper presents the analysis employed to calculate these parameters and the development and reasoning behind their use. It also discusses the planning of A-U measurements for materials and structures to be studied. Types of transducer coupling are discussed including contact and non-contact via laser and air. Experimental planning includes matching transducer frequency range to material and geometry of the specimen to be studied. The effect on results of initially zeroing the DC component of the ultrasonic waveform is compared with not doing so. A wide range of interrogation problems are addressed via the application of these analysis parameters to real specimens is shown for five cases: Case 1: Differences in density in [0] SiC/RBSN ceramic matrix composite. Case 2: Effect of tensile fatigue cycling in [+/-45] SiC/SiC ceramic matrix composite. Case 3: Detecting creep life, and failure, in Udimet 520 Nickel-Based Super Alloy. Case 4: Detecting Surface Layer Formation in T-650-35/PMR-15 Polymer Matrix Composites Panels due to Thermal Aging. Case 5: Detecting Spin Test Degradation in PMC Flywheels. Among these cases a wide range of materials and geometries are studied.

  13. Evaluation of different mathematical models and different b-value ranges of diffusion-weighted imaging in peripheral zone prostate cancer detection using b-value up to 4500 s/mm2

    PubMed Central

    Feng, Zhaoyan; Min, Xiangde; Margolis, Daniel J. A.; Duan, Caohui; Chen, Yuping; Sah, Vivek Kumar; Chaudhary, Nabin; Li, Basen; Ke, Zan; Zhang, Peipei; Wang, Liang

    2017-01-01

    Objectives To evaluate the diagnostic performance of different mathematical models and different b-value ranges of diffusion-weighted imaging (DWI) in peripheral zone prostate cancer (PZ PCa) detection. Methods Fifty-six patients with histologically proven PZ PCa who underwent DWI-magnetic resonance imaging (MRI) using 21 b-values (0–4500 s/mm2) were included. The mean signal intensities of the regions of interest (ROIs) placed in benign PZs and cancerous tissues on DWI images were fitted using mono-exponential, bi-exponential, stretched-exponential, and kurtosis models. The b-values were divided into four ranges: 0–1000, 0–2000, 0–3200, and 0–4500 s/mm2, grouped as A, B, C, and D, respectively. ADC, , D*, f, DDC, α, Dapp, and Kapp were estimated for each group. The adjusted coefficient of determination (R2) was calculated to measure goodness-of-fit. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic performance of the parameters. Results All parameters except D* showed significant differences between cancerous tissues and benign PZs in each group. The area under the curve values (AUCs) of ADC were comparable in groups C and D (p = 0.980) and were significantly higher than those in groups A and B (p< 0.05 for all). The AUCs of ADC and Kapp in groups B and C were similar (p = 0.07 and p = 0.954), and were significantly higher than the other parameters (p< 0.001 for all). The AUCs of ADC in group D was slightly higher than Kapp (p = 0.002), and both were significantly higher than the other parameters (p< 0.001 for all). Conclusions ADC derived from conventional mono-exponential high b-value (3200 s/mm2) models is an optimal parameter for PZ PCa detection. PMID:28199367

  14. Cell-Division Behavior in a Heterogeneous Swarm Environment.

    PubMed

    Erskine, Adam; Herrmann, J Michael

    2015-01-01

    We present a system of virtual particles that interact using simple kinetic rules. It is known that heterogeneous mixtures of particles can produce particularly interesting behaviors. Here we present a two-species three-dimensional swarm in which a behavior emerges that resembles cell division. We show that the dividing behavior exists across a narrow but finite band of parameters and for a wide range of population sizes. When executed in a two-dimensional environment the swarm's characteristics and dynamism manifest differently. In further experiments we show that repeated divisions can occur if the system is extended by a biased equilibrium process to control the split of populations. We propose that this repeated division behavior provides a simple model for cell-division mechanisms and is of interest for the formation of morphological structure and to swarm robotics.

  15. Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment

    EPA Science Inventory

    This pyrethroid insecticide parameter review is an extension of our interest in developing quantitative structure–activity relationship–physiologically based pharmacokinetic/pharmacodynamic (QSAR-PBPK/PD) models for assessing health risks, which interest started with the organoph...

  16. Hydrodynamic resistance parameters for ErPr rare-earth regenerator material under steady and periodic flow conditions

    NASA Astrophysics Data System (ADS)

    Pathak, M. G.; Helvensteijn, B. P.; Patel, V. C.; Ghiaasiaan, S. M.; Mulcahey, T. I.; Kashani, A.; Feller, J. R.

    2014-01-01

    The regenerator, typically a microporous structure that is subject to periodic flow of a cryogenic fluid, is a critical component of pulse tube or Stirling cryocoolers, which are widely used for high-demand aerospace and defense applications. In this investigation, experiments were conducted in which steady and oscillatory flows of helium were imposed on ErPr rare-Earth regenerator filler material and mass flow and pressure drop data were recorded under ambient temperature conditions. A computational fluid dynamics (CFD)-assisted method was applied for the analysis and interpretation of the experimental data. The permeability and inertial coefficients that lead to agreement between the experimental data and computational simulations were iteratively obtained. The Darcy permeability and Forchheimer inertial coefficients were obtained and were found to be functions of the system charge pressure, operating frequency, and compressor piston stroke within the studied range of interest. The results also exhibit that the periodic flow hydrodynamic resistance parameters are in general different than steady flow parameters.

  17. A4 flavour model for Dirac neutrinos: Type I and inverse seesaw

    NASA Astrophysics Data System (ADS)

    Borah, Debasish; Karmakar, Biswajit

    2018-05-01

    We propose two different seesaw models namely, type I and inverse seesaw to realise light Dirac neutrinos within the framework of A4 discrete flavour symmetry. The additional fields and their transformations under the flavour symmetries are chosen in such a way that naturally predicts the hierarchies of different elements of the seesaw mass matrices in these two types of seesaw mechanisms. For generic choices of flavon alignments, both the models predict normal hierarchical light neutrino masses with the atmospheric mixing angle in the lower octant. Apart from predicting interesting correlations between different neutrino parameters as well as between neutrino and model parameters, the model also predicts the leptonic Dirac CP phase to lie in a specific range - π / 3 to π / 3. While the type I seesaw model predicts smaller values of absolute neutrino mass, the inverse seesaw predictions for the absolute neutrino masses can saturate the cosmological upper bound on sum of absolute neutrino masses for certain choices of model parameters.

  18. The Light Side of Dark Matter

    NASA Astrophysics Data System (ADS)

    Cisneros, Sophia

    2013-04-01

    We present a new, heuristic, two-parameter model for predicting the rotation curves of disc galaxies. The model is tested on (22) randomly chosen galaxies, represented in 35 data sets. This Lorentz Convolution [LC] model is derived from a non-linear, relativistic solution of a Kerr-type wave equation, where small changes in the photon's frequencies, resulting from the curved space time, are convolved into a sequence of Lorentz transformations. The LC model is parametrized with only the diffuse, luminous stellar and gaseous masses reported with each data set of observations used. The LC model predicts observed rotation curves across a wide range of disk galaxies. The LC model was constructed to occupy the same place in the explanation of rotation curves that Dark Matter does, so that a simple investigation of the relation between luminous and dark matter might be made, via by a parameter (a). We find the parameter (a) to demonstrate interesting structure. We compare the new model prediction to both the NFW model and MOND fits when available.

  19. Nonlinear saturation of the slab ITG instability and zonal flow generation with fully kinetic ions

    NASA Astrophysics Data System (ADS)

    Miecnikowski, Matthew T.; Sturdevant, Benjamin J.; Chen, Yang; Parker, Scott E.

    2018-05-01

    Fully kinetic turbulence models are of interest for their potential to validate or replace gyrokinetic models in plasma regimes where the gyrokinetic expansion parameters are marginal. Here, we demonstrate fully kinetic ion capability by simulating the growth and nonlinear saturation of the ion-temperature-gradient instability in shearless slab geometry assuming adiabatic electrons and including zonal flow dynamics. The ion trajectories are integrated using the Lorentz force, and the cyclotron motion is fully resolved. Linear growth and nonlinear saturation characteristics show excellent agreement with analogous gyrokinetic simulations across a wide range of parameters. The fully kinetic simulation accurately reproduces the nonlinearly generated zonal flow. This work demonstrates nonlinear capability, resolution of weak gradient drive, and zonal flow physics, which are critical aspects of modeling plasma turbulence with full ion dynamics.

  20. Flux estimation of the FIFE planetary boundary layer (PBL) with 10.6 micron Doppler lidar

    NASA Technical Reports Server (NTRS)

    Gal-Chen, Tzvi; Xu, Mei; Eberhard, Wynn

    1990-01-01

    A method is devised for calculating wind, momentum, and other flux parameters that characterize the planetary boundary layer (PBL) and thereby facilitate the calibration of spaceborne vs. in situ flux estimates. Single Doppler lidar data are used to estimate the variance of the mean wind and the covariance related to the vertically pointing fluxes of horizontal momentum. The skewness of the vertical velocity and the range of kinetic energy dissipation are also estimated, and the surface heat flux is determined by means of a statistical Navier-Stokes equation. The conclusion shows that the PBL structure combines both 'bottom-up' and 'top-down' processes suggesting that the relevant parameters for the atmospheric boundary layer be revised. The conclusions are of significant interest to the modeling techniques used in General Circulation Models as well as to flux estimation.

  1. General equations for the motions of ice crystals and water drops in gravitational and electric fields

    NASA Technical Reports Server (NTRS)

    Nisbet, John S.

    1988-01-01

    General equations for the Reynolds number of a variety of types of ice crystals and water drops are given in terms of the Davies, Bond, and Knudsen numbers. The equations are in terms of the basic physical parameters of the system and are valid for calculating velocities in gravitational and electric fields over a very wide range of sizes and atmospheric conditions. The equations are asymptotically matched at the bottom and top of the size spectrum, useful when checking large computer codes. A numerical system for specifying the dimensional properties of ice crystals is introduced. Within the limits imposed by such variables as particle density, which have large deviations, the accuracy of velocities appears to be within 10 percent over the entire range of sizes of interest.

  2. Magnetic characteristics of M2FeV3O11 (M = Mg, Zn, Pb, Co, Ni) compounds

    NASA Astrophysics Data System (ADS)

    Groń, T.; Blonska-Tabero, A.; Filipek, E.; Stokłosa, Z.; Duda, H.; Sawicki, B.

    2018-02-01

    The unusual physical characteristics of the multicomponent oxide systems renewed the interest as the potential cathode materials in high-energy cells. Since the earlier magnetic characteristics were not entirely conclusive, we report the results of dc magnetic measurements including higher harmonics of ac magnetic susceptibility of the M2FeV3O11 (M = Mg, Zn, Pb, Co, Ni) compounds. Ferrimagnetic long-range and antiferromagnetic short-range interactions for all compounds under study at low temperatures as well as superparamagnetic-like behavior with the blocking temperature of 29 K and the freezing parameter of 0.013 were observed. These effects are discussed within the framework of superexchange and double exchange magnetic interactions as well as the mixed valence band of iron ions.

  3. Long-range dependence and multifractality in the term structure of LIBOR interest rates

    NASA Astrophysics Data System (ADS)

    Cajueiro, Daniel O.; Tabak, Benjamin M.

    2007-01-01

    In this paper we present evidence of long-range dependence in LIBOR interest rates. We study a data set from 2000 to 2005, for six different currencies and various maturities. Empirical results suggest that the degree of long-range dependence decreases with maturity, with the exception of interest rates on Japanese Yen and on Indonesian Rupiah. Furthermore, interest rates have a multifractal nature and the degree of multifractality is much stronger for Indonesia (emerging market). These findings suggest that interest rates derivatives should take these features into account. Furthermore, fixed income risk and portfolio management should incorporate long-range dependence in the modeling of interest rates.

  4. Multiple frequency method for operating electrochemical sensors

    DOEpatents

    Martin, Louis P [San Ramon, CA

    2012-05-15

    A multiple frequency method for the operation of a sensor to measure a parameter of interest using calibration information including the steps of exciting the sensor at a first frequency providing a first sensor response, exciting the sensor at a second frequency providing a second sensor response, using the second sensor response at the second frequency and the calibration information to produce a calculated concentration of the interfering parameters, using the first sensor response at the first frequency, the calculated concentration of the interfering parameters, and the calibration information to measure the parameter of interest.

  5. A Multialgorithm Approach to Land Surface Modeling of Suspended Sediment in the Colorado Front Range

    PubMed Central

    Stewart, J. R.; Kasprzyk, J. R.; Rajagopalan, B.; Minear, J. T.; Raseman, W. J.

    2017-01-01

    Abstract A new paradigm of simulating suspended sediment load (SSL) with a Land Surface Model (LSM) is presented here. Five erosion and SSL algorithms were applied within a common LSM framework to quantify uncertainties and evaluate predictability in two steep, forested catchments (>1,000 km2). The algorithms were chosen from among widely used sediment models, including empirically based: monovariate rating curve (MRC) and the Modified Universal Soil Loss Equation (MUSLE); stochastically based: the Load Estimator (LOADEST); conceptually based: the Hydrologic Simulation Program—Fortran (HSPF); and physically based: the Distributed Hydrology Soil Vegetation Model (DHSVM). The algorithms were driven by the hydrologic fluxes and meteorological inputs generated from the Variable Infiltration Capacity (VIC) LSM. A multiobjective calibration was applied to each algorithm and optimized parameter sets were validated over an excluded period, as well as in a transfer experiment to a nearby catchment to explore parameter robustness. Algorithm performance showed consistent decreases when parameter sets were applied to periods with greatly differing SSL variability relative to the calibration period. Of interest was a joint calibration of all sediment algorithm and streamflow parameters simultaneously, from which trade‐offs between streamflow performance and partitioning of runoff and base flow to optimize SSL timing were noted, decreasing the flexibility and robustness of the streamflow to adapt to different time periods. Parameter transferability to another catchment was most successful in more process‐oriented algorithms, the HSPF and the DHSVM. This first‐of‐its‐kind multialgorithm sediment scheme offers a unique capability to portray acute episodic loading while quantifying trade‐offs and uncertainties across a range of algorithm structures. PMID:29399268

  6. Who picks psychiatry? Perceptions, preferences and personality of medical students.

    PubMed

    Malhi, Gin S; Coulston, Carissa M; Parker, Gordon B; Cashman, Emma; Walter, Garry; Lampe, Lisa A; Vollmer-Conna, Ute

    2011-10-01

    This study aimed to characterise the personality profiles of junior medical students most likely to choose psychiatry as a career, determine aspects of psychiatry that most attract potential recruits, and identify misperceptions about psychiatry that may dissuade students from pursuing this specialism. A total of 580 second-year medical students from the University of New South Wales, Australia completed a set of questionnaires that measured the likelihood with which various medical specialties were being considered as careers, personality traits using the NEO Five-Factor Inventory (NEO-FFI), and the degree to which students perceived each specialty as attractive across a number of parameters. Only 86 students (15%) indicated a strong likelihood of choosing psychiatry, compared to other specialties which attracted higher proportions of students (range 19-49%). These 86 students had significantly higher openness scores than those who indicated a lesser likelihood of pursuing psychiatry. Students who were highly interested in psychiatry ranked it as very attractive in respect to providing interesting and challenging subject matter, and relatively attractive in respect to financial reward, work enjoyment, good lifestyle, having a bright and interesting future, and association with colleagues. However, psychiatry remained less attractive with respect to prestige, perceived low effectiveness of treatments, degree to which it draws upon aspects of medical training, and lack of reliable scientific foundation. Within the entire sample, psychiatry was ranked most unattractive compared to the other specialties across eight of the 13 parameters assessed. Students interested in psychiatry are more likely to be 'open' and view the specialty as interesting and challenging. Such characteristics should be promoted more widely along with countering myths that as a specialty, psychiatry lacks a scientific foundation or is somehow different from mainstream medicine in terms of training and outcomes. Championing psychiatry in this manner may attract more recruits and enhance its prestige.

  7. Developing a non-point source P loss indicator in R and its parameter uncertainty assessment using GLUE: a case study in northern China.

    PubMed

    Su, Jingjun; Du, Xinzhong; Li, Xuyong

    2018-05-16

    Uncertainty analysis is an important prerequisite for model application. However, the existing phosphorus (P) loss indexes or indicators were rarely evaluated. This study applied generalized likelihood uncertainty estimation (GLUE) method to assess the uncertainty of parameters and modeling outputs of a non-point source (NPS) P indicator constructed in R language. And the influences of subjective choices of likelihood formulation and acceptability threshold of GLUE on model outputs were also detected. The results indicated the following. (1) Parameters RegR 2 , RegSDR 2 , PlossDP fer , PlossDP man , DPDR, and DPR were highly sensitive to overall TP simulation and their value ranges could be reduced by GLUE. (2) Nash efficiency likelihood (L 1 ) seemed to present better ability in accentuating high likelihood value simulations than the exponential function (L 2 ) did. (3) The combined likelihood integrating the criteria of multiple outputs acted better than single likelihood in model uncertainty assessment in terms of reducing the uncertainty band widths and assuring the fitting goodness of whole model outputs. (4) A value of 0.55 appeared to be a modest choice of threshold value to balance the interests between high modeling efficiency and high bracketing efficiency. Results of this study could provide (1) an option to conduct NPS modeling under one single computer platform, (2) important references to the parameter setting for NPS model development in similar regions, (3) useful suggestions for the application of GLUE method in studies with different emphases according to research interests, and (4) important insights into the watershed P management in similar regions.

  8. Understanding animal health communication networks among smallholder livestock producers in Australia using stakeholder analysis.

    PubMed

    Hayes, L; Woodgate, R; Rast, L; Toribio, J-A L M L; Hernández-Jover, M

    2017-09-01

    Smallholder livestock producers are a diverse population with wide ranging motivations for keeping livestock. The biosecurity risk posed by smallholders has been the subject of much conjecture, with comparisons often made between the level of animal health and biosecurity knowledge of smallholders, versus that of commercial livestock producers. This research aimed to gain a better understanding of current knowledge of smallholder production in Australia, particularly in relation to biosecurity and emergency animal disease, and to investigate the relationships that exist between smallholders and the organisations and individuals from which they seek information, assistance and support. Engagement with stakeholders is an important component of an effective biosecurity communication strategy as the dissemination of biosecurity related information from a single source cannot be expected to satisfy the needs of such a broad ranging population. A qualitative study involving a review of literature, semi-structured interviews with government and non-government stakeholders and the development of smallholder and stakeholder influence and interest grids was undertaken. This paper forms part of a broader mixed methods research project among smallholders. Results from the stakeholder analysis showed variation in the parameters used to define smallholders and in the level of stakeholder involvement. Smallholders identified breeding consultants, other producers, private veterinarians and family, friends and colleagues as having a significant to high level of interest and potential to influence their practices. Government agencies were perceived to only have some level of interest but significant influence. Industry stakeholders and rural suppliers were positioned in the quadrant reflecting perceived low levels of interest and influence. The interest and influence grid developed from stakeholder's perspectives demonstrate a clustering around the mid points for both interest and influence, with the exception of those from industry who described low levels of interest and influence. Commonwealth and State government stakeholders reported a higher level of interest than influence. Veterinarians, both government and private, reported some to significant levels of interest and influence. In contrast to the results from the smallholder grid, rural suppliers reported relatively high levels of both interest and influence. The current study demonstrates that to maximise the effectiveness of biosecurity communication, there is a need for government and industry organisations to further engage with all stakeholders involved with smallholders. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Geothermal Life Cycle Calculator

    DOE Data Explorer

    Sullivan, John

    2014-03-11

    This calculator is a handy tool for interested parties to estimate two key life cycle metrics, fossil energy consumption (Etot) and greenhouse gas emission (ghgtot) ratios, for geothermal electric power production. It is based solely on data developed by Argonne National Laboratory for DOE’s Geothermal Technologies office. The calculator permits the user to explore the impact of a range of key geothermal power production parameters, including plant capacity, lifetime, capacity factor, geothermal technology, well numbers and depths, field exploration, and others on the two metrics just mentioned. Estimates of variations in the results are also available to the user.

  10. Resistive wall wakefields of short bunches at cryogenic temperatures

    DOE PAGES

    Stupakov, G.; Bane, K. L. F.; Emma, P.; ...

    2015-03-19

    In this study, we present calculations of the longitudinal wakefields at cryogenic temperatures for extremely short bunches, characteristic for modern x-ray free electron lasers. The calculations are based on the equations for the surface impedance in the regime of the anomalous skin effect in metals. This paper extends and complements an earlier analysis of B. Podobedov, Phys. Rev. ST Accel. Beams 12, 044401 (2009). into the region of very high frequencies associated with bunch lengths in the micron range. We study in detail the case of a rectangular bunch distribution for parameters of interest of LCLS-II with a superconducting undulator.

  11. A life cycle cost economics model for automation projects with uniformly varying operating costs. [applied to Deep Space Network and Air Force Systems Command

    NASA Technical Reports Server (NTRS)

    Remer, D. S.

    1977-01-01

    The described mathematical model calculates life-cycle costs for projects with operating costs increasing or decreasing linearly with time. The cost factors involved in the life-cycle cost are considered, and the errors resulting from the assumption of constant rather than uniformly varying operating costs are examined. Parameters in the study range from 2 to 30 years, for project life; 0 to 15% per year, for interest rate; and 5 to 90% of the initial operating cost, for the operating cost gradient. A numerical example is presented.

  12. JEUMICO: Czech-Bavarian astronomical X-ray optics project

    NASA Astrophysics Data System (ADS)

    Hudec, R.; Döhring, T.

    2017-07-01

    Within the project JEUMICO, an acronym for "Joint European Mirror Competence", the Aschaffenburg University of Applied Sciences and the Czech Technical University in Prague started a collaboration to develop mirrors for X-ray telescopes. Corresponding mirror segments use substrates of flat silicon wafers which are coated with thin iridium films, as this material is promising high reflectivity in the X-ray range of interest. The sputtering parameters are optimized in the context of the expected reflectivity of the coated X-ray mirrors. In near future measurements of the assembled mirror modules optical performances are planned at an X-ray test facility.

  13. Parametric Studies of Square Solar Sails Using Finite Element Analysis

    NASA Technical Reports Server (NTRS)

    Sleight, David W.; Muheim, Danniella M.

    2004-01-01

    Parametric studies are performed on two generic square solar sail designs to identify parameters of interest. The studies are performed on systems-level models of full-scale solar sails, and include geometric nonlinearity and inertia relief, and use a Newton-Raphson scheme to apply sail pre-tensioning and solar pressure. Computational strategies and difficulties encountered during the analyses are also addressed. The purpose of this paper is not to compare the benefits of one sail design over the other. Instead, the results of the parametric studies may be used to identify general response trends, and areas of potential nonlinear structural interactions for future studies. The effects of sail size, sail membrane pre-stress, sail membrane thickness, and boom stiffness on the sail membrane and boom deformations, boom loads, and vibration frequencies are studied. Over the range of parameters studied, the maximum sail deflection and boom deformations are a nonlinear function of the sail properties. In general, the vibration frequencies and modes are closely spaced. For some vibration mode shapes, local deformation patterns that dominate the response are identified. These localized patterns are attributed to the presence of negative stresses in the sail membrane that are artifacts of the assumption of ignoring the effects of wrinkling in the modeling process, and are not believed to be physically meaningful. Over the range of parameters studied, several regions of potential nonlinear modal interaction are identified.

  14. Scaling properties of weakly nonlinear coefficients in the Faraday problem.

    PubMed

    Skeldon, A C; Porter, J

    2011-07-01

    Interesting and exotic surface wave patterns have regularly been observed in the Faraday experiment. Although symmetry arguments provide a qualitative explanation for the selection of some of these patterns (e.g., superlattices), quantitative analysis is hindered by mathematical difficulties inherent in a time-dependent, free-boundary Navier-Stokes problem. More tractable low viscosity approximations are available, but these do not necessarily capture the moderate viscosity regime of the most interesting experiments. Here we focus on weakly nonlinear behavior and compare the scaling results derived from symmetry arguments in the low viscosity limit with the computed coefficients of appropriate amplitude equations using both the full Navier-Stokes equations and a reduced set of partial differential equations due to Zhang and Vinãls. We find the range of viscosities over which one can expect "low viscosity" theories to hold. We also find that there is an optimal viscosity range for locating superlattice patterns experimentally-large enough that the region of parameters giving stable patterns is not impracticably small, yet not so large that crucial resonance effects are washed out. These results help explain some of the discrepancies between theory and experiment.

  15. Assessing the Value of Biosimilars: A Review of the Role of Budget Impact Analysis.

    PubMed

    Simoens, Steven; Jacobs, Ira; Popovian, Robert; Isakov, Leah; Shane, Lesley G

    2017-10-01

    Biosimilar drugs are highly similar to an originator (reference) biologic, with no clinically meaningful differences in terms of safety or efficacy. As biosimilars offer the potential for lower acquisition costs versus the originator biologic, evaluating the economic implications of the introduction of biosimilars is of interest. Budget impact analysis (BIA) is a commonly used methodology. This review of published BIAs of biosimilar fusion proteins and/or monoclonal antibodies identified 12 unique publications (three full papers and nine congress posters). When evaluated alongside professional guidance on conducting BIA, the majority of BIAs identified were generally in line with international recommendations. However, a lack of peer-reviewed journal articles and considerable shortcomings in the publications were identified. Deficiencies included a limited range of cost parameters, a reliance on assumptions for parameters such as uptake and drug pricing, a lack of expert validation, and a limited range of sensitivity analyses that were based on arbitrary ranges. The rationale for the methods employed, limitations of the BIA approach, and instructions for local adaptation often were inadequately discussed. To understand fully the potential economic impact and value of biosimilars, the impact of biosimilar supply, manufacturer-provided supporting services, and price competition should be included in BIAs. Alternative approaches, such as cost minimization, which requires evidence demonstrating similarity to the originator biologic, and those that integrate a range of economic assessment methods, are needed to assess the value of biosimilars.

  16. Review of 3D image data calibration for heterogeneity correction in proton therapy treatment planning.

    PubMed

    Zhu, Jiahua; Penfold, Scott N

    2016-06-01

    Correct modelling of the interaction parameters of patient tissues is of vital importance in proton therapy treatment planning because of the large dose gradients associated with the Bragg peak. Different 3D imaging techniques yield different information regarding these interaction parameters. Given the rapidly expanding interest in proton therapy, this review is written to make readers aware of the current challenges in accounting for tissue heterogeneities and the imaging systems that are proposed to tackle these challenges. A summary of the interaction parameters of interest in proton therapy and the current and developmental 3D imaging techniques used in proton therapy treatment planning is given. The different methods to translate the imaging data to the interaction parameters of interest are reviewed and a summary of the implementations in several commercial treatment planning systems is presented.

  17. Real­-Time Ensemble Forecasting of Coronal Mass Ejections Using the Wsa-Enlil+Cone Model

    NASA Astrophysics Data System (ADS)

    Mays, M. L.; Taktakishvili, A.; Pulkkinen, A. A.; Odstrcil, D.; MacNeice, P. J.; Rastaetter, L.; LaSota, J. A.

    2014-12-01

    Ensemble forecasting of coronal mass ejections (CMEs) provides significant information in that it provides an estimation of the spread or uncertainty in CME arrival time predictions. Real-time ensemble modeling of CME propagation is performed by forecasters at the Space Weather Research Center (SWRC) using the WSA-ENLIL+cone model available at the Community Coordinated Modeling Center (CCMC). To estimate the effect of uncertainties in determining CME input parameters on arrival time predictions, a distribution of n (routinely n=48) CME input parameter sets are generated using the CCMC Stereo CME Analysis Tool (StereoCAT) which employs geometrical triangulation techniques. These input parameters are used to perform n different simulations yielding an ensemble of solar wind parameters at various locations of interest, including a probability distribution of CME arrival times (for hits), and geomagnetic storm strength (for Earth-directed hits). We present the results of ensemble simulations for a total of 38 CME events in 2013-2014. For 28 of the ensemble runs containing hits, the observed CME arrival was within the range of ensemble arrival time predictions for 14 runs (half). The average arrival time prediction was computed for each of the 28 ensembles predicting hits and using the actual arrival time, an average absolute error of 10.0 hours (RMSE=11.4 hours) was found for all 28 ensembles, which is comparable to current forecasting errors. Some considerations for the accuracy of ensemble CME arrival time predictions include the importance of the initial distribution of CME input parameters, particularly the mean and spread. When the observed arrivals are not within the predicted range, this still allows the ruling out of prediction errors caused by tested CME input parameters. Prediction errors can also arise from ambient model parameters such as the accuracy of the solar wind background, and other limitations. Additionally the ensemble modeling sysem was used to complete a parametric event case study of the sensitivity of the CME arrival time prediction to free parameters for ambient solar wind model and CME. The parameter sensitivity study suggests future directions for the system, such as running ensembles using various magnetogram inputs to the WSA model.

  18. A Range Finding Protocol to Support Design for Transcriptomics Experimentation: Examples of In-Vitro and In-Vivo Murine UV Exposure

    PubMed Central

    van Oostrom, Conny T.; Jonker, Martijs J.; de Jong, Mark; Dekker, Rob J.; Rauwerda, Han; Ensink, Wim A.; de Vries, Annemieke; Breit, Timo M.

    2014-01-01

    In transcriptomics research, design for experimentation by carefully considering biological, technological, practical and statistical aspects is very important, because the experimental design space is essentially limitless. Usually, the ranges of variable biological parameters of the design space are based on common practices and in turn on phenotypic endpoints. However, specific sub-cellular processes might only be partially reflected by phenotypic endpoints or outside the associated parameter range. Here, we provide a generic protocol for range finding in design for transcriptomics experimentation based on small-scale gene-expression experiments to help in the search for the right location in the design space by analyzing the activity of already known genes of relevant molecular mechanisms. Two examples illustrate the applicability: in-vitro UV-C exposure of mouse embryonic fibroblasts and in-vivo UV-B exposure of mouse skin. Our pragmatic approach is based on: framing a specific biological question and associated gene-set, performing a wide-ranged experiment without replication, eliminating potentially non-relevant genes, and determining the experimental ‘sweet spot’ by gene-set enrichment plus dose-response correlation analysis. Examination of many cellular processes that are related to UV response, such as DNA repair and cell-cycle arrest, revealed that basically each cellular (sub-) process is active at its own specific spot(s) in the experimental design space. Hence, the use of range finding, based on an affordable protocol like this, enables researchers to conveniently identify the ‘sweet spot’ for their cellular process of interest in an experimental design space and might have far-reaching implications for experimental standardization. PMID:24823911

  19. Bayesian multiple-source localization in an uncertain ocean environment.

    PubMed

    Dosso, Stan E; Wilmut, Michael J

    2011-06-01

    This paper considers simultaneous localization of multiple acoustic sources when properties of the ocean environment (water column and seabed) are poorly known. A Bayesian formulation is developed in which the environmental parameters, noise statistics, and locations and complex strengths (amplitudes and phases) of multiple sources are considered to be unknown random variables constrained by acoustic data and prior information. Two approaches are considered for estimating source parameters. Focalization maximizes the posterior probability density (PPD) over all parameters using adaptive hybrid optimization. Marginalization integrates the PPD using efficient Markov-chain Monte Carlo methods to produce joint marginal probability distributions for source ranges and depths, from which source locations are obtained. This approach also provides quantitative uncertainty analysis for all parameters, which can aid in understanding of the inverse problem and may be of practical interest (e.g., source-strength probability distributions). In both approaches, closed-form maximum-likelihood expressions for source strengths and noise variance at each frequency allow these parameters to be sampled implicitly, substantially reducing the dimensionality and difficulty of the inversion. Examples are presented of both approaches applied to single- and multi-frequency localization of multiple sources in an uncertain shallow-water environment, and a Monte Carlo performance evaluation study is carried out. © 2011 Acoustical Society of America

  20. Variations in algorithm implementation among quantitative texture analysis software packages

    NASA Astrophysics Data System (ADS)

    Foy, Joseph J.; Mitta, Prerana; Nowosatka, Lauren R.; Mendel, Kayla R.; Li, Hui; Giger, Maryellen L.; Al-Hallaq, Hania; Armato, Samuel G.

    2018-02-01

    Open-source texture analysis software allows for the advancement of radiomics research. Variations in texture features, however, result from discrepancies in algorithm implementation. Anatomically matched regions of interest (ROIs) that captured normal breast parenchyma were placed in the magnetic resonance images (MRI) of 20 patients at two time points. Six first-order features and six gray-level co-occurrence matrix (GLCM) features were calculated for each ROI using four texture analysis packages. Features were extracted using package-specific default GLCM parameters and using GLCM parameters modified to yield the greatest consistency among packages. Relative change in the value of each feature between time points was calculated for each ROI. Distributions of relative feature value differences were compared across packages. Absolute agreement among feature values was quantified by the intra-class correlation coefficient. Among first-order features, significant differences were found for max, range, and mean, and only kurtosis showed poor agreement. All six second-order features showed significant differences using package-specific default GLCM parameters, and five second-order features showed poor agreement; with modified GLCM parameters, no significant differences among second-order features were found, and all second-order features showed poor agreement. While relative texture change discrepancies existed across packages, these differences were not significant when consistent parameters were used.

  1. Laser Direct Metal Deposition of 2024 Al Alloy: Trace Geometry Prediction via Machine Learning.

    PubMed

    Caiazzo, Fabrizia; Caggiano, Alessandra

    2018-03-19

    Laser direct metal deposition is an advanced additive manufacturing technology suitably applicable in maintenance, repair, and overhaul of high-cost products, allowing for minimal distortion of the workpiece, reduced heat affected zones, and superior surface quality. Special interest is growing for the repair and coating of 2024 aluminum alloy parts, extensively utilized for a wide range of applications in the automotive, military, and aerospace sectors due to its excellent plasticity, corrosion resistance, electric conductivity, and strength-to-weight ratio. A critical issue in the laser direct metal deposition process is related to the geometrical parameters of the cross-section of the deposited metal trace that should be controlled to meet the part specifications. In this research, a machine learning approach based on artificial neural networks is developed to find the correlation between the laser metal deposition process parameters and the output geometrical parameters of the deposited metal trace produced by laser direct metal deposition on 5-mm-thick 2024 aluminum alloy plates. The results show that the neural network-based machine learning paradigm is able to accurately estimate the appropriate process parameters required to obtain a specified geometry for the deposited metal trace.

  2. Laser Direct Metal Deposition of 2024 Al Alloy: Trace Geometry Prediction via Machine Learning

    PubMed Central

    2018-01-01

    Laser direct metal deposition is an advanced additive manufacturing technology suitably applicable in maintenance, repair, and overhaul of high-cost products, allowing for minimal distortion of the workpiece, reduced heat affected zones, and superior surface quality. Special interest is growing for the repair and coating of 2024 aluminum alloy parts, extensively utilized for a wide range of applications in the automotive, military, and aerospace sectors due to its excellent plasticity, corrosion resistance, electric conductivity, and strength-to-weight ratio. A critical issue in the laser direct metal deposition process is related to the geometrical parameters of the cross-section of the deposited metal trace that should be controlled to meet the part specifications. In this research, a machine learning approach based on artificial neural networks is developed to find the correlation between the laser metal deposition process parameters and the output geometrical parameters of the deposited metal trace produced by laser direct metal deposition on 5-mm-thick 2024 aluminum alloy plates. The results show that the neural network-based machine learning paradigm is able to accurately estimate the appropriate process parameters required to obtain a specified geometry for the deposited metal trace. PMID:29562682

  3. Interference correction by extracting the information of interference dominant regions: Application to near-infrared spectra

    NASA Astrophysics Data System (ADS)

    Bi, Yiming; Tang, Liang; Shan, Peng; Xie, Qiong; Hu, Yong; Peng, Silong; Tan, Jie; Li, Changwen

    2014-08-01

    Interference such as baseline drift and light scattering can degrade the model predictability in multivariate analysis of near-infrared (NIR) spectra. Usually interference can be represented by an additive and a multiplicative factor. In order to eliminate these interferences, correction parameters are needed to be estimated from spectra. However, the spectra are often mixed of physical light scattering effects and chemical light absorbance effects, making it difficult for parameter estimation. Herein, a novel algorithm was proposed to find a spectral region automatically that the interesting chemical absorbance and noise are low, that is, finding an interference dominant region (IDR). Based on the definition of IDR, a two-step method was proposed to find the optimal IDR and the corresponding correction parameters estimated from IDR. Finally, the correction was performed to the full spectral range using previously obtained parameters for the calibration set and test set, respectively. The method can be applied to multi target systems with one IDR suitable for all targeted analytes. Tested on two benchmark data sets of near-infrared spectra, the performance of the proposed method provided considerable improvement compared with full spectral estimation methods and comparable with other state-of-art methods.

  4. Primary production sensitivity to phytoplankton light attenuation parameter increases with transient forcing

    NASA Astrophysics Data System (ADS)

    Kvale, Karin F.; Meissner, Katrin J.

    2017-10-01

    Treatment of the underwater light field in ocean biogeochemical models has been attracting increasing interest, with some models moving towards more complex parameterisations. We conduct a simple sensitivity study of a typical, highly simplified parameterisation. In our study, we vary the phytoplankton light attenuation parameter over a range constrained by data during both pre-industrial equilibrated and future climate scenario RCP8.5. In equilibrium, lower light attenuation parameters (weaker self-shading) shift net primary production (NPP) towards the high latitudes, while higher values of light attenuation (stronger shelf-shading) shift NPP towards the low latitudes. Climate forcing magnifies this relationship through changes in the distribution of nutrients both within and between ocean regions. Where and how NPP responds to climate forcing can determine the magnitude and sign of global NPP trends in this high CO2 future scenario. Ocean oxygen is particularly sensitive to parameter choice. Under higher CO2 concentrations, two simulations establish a strong biogeochemical feedback between the Southern Ocean and low-latitude Pacific that highlights the potential for regional teleconnection. Our simulations serve as a reminder that shifts in fundamental properties (e.g. light attenuation by phytoplankton) over deep time have the potential to alter global biogeochemistry.

  5. Experimental Aspects in Beam Characterization

    NASA Astrophysics Data System (ADS)

    Sona, Alberto

    2004-08-01

    Beam characterization is the pre-requisite of any research exploiting light beams, especially in cases involving laser beams. One can rely on the beam parameters provided by the manufacturer but often they are inadequate and/or not sufficient for the experimental data analysis. The full characterization of a laser beam can require the determination of many parameters (about ten for a generic beam); however for symmetrical beams the significant ones can reduce to only to a few. The characterization can be performed with the accuracy requested by the application and limited to the relevant parameters. The main parameters of interest will be defined and the measurement procedures and equipment will be discussed. The ISO standards consider the following parameters mainly of interest for industrial applications: 1) Beam widths, divergence angle and beam propagation ratio. 2) Power, energy density distribution 3) Parameters for stigmatic and simple astigmatic beams 4) Parameters for general astigmatic beams 5) Geometrical laser beams classification and propagation 6) Power, energy and temporal characteristics 7) Beam positional stability 8) Beam polarization 9) Spectral characteristics 10) Shape of a laser wavefront: Phase distribution All the above points will be briefly discussed as regards the experimental problems involved. Special attention will be given to the methods for measuring the intensity distribution and to the related instrumentation to derive the Beam propagation ratio, the Beam Quality factor M2 or the Beam Parameters Product. Examples of the parameters relevance for specific applications will be given. Depending on the spectral range, specific detectors are used: CCD cameras with detector arrays in the visible and near infrared, thermocameras with a single detector and scanning system for the medium and far IR. The major problems in data collection and processing will be discussed. Another new and not yet fully investigated area is the characterization of laser beam by wavefront measuring instruments. One possible approach is the use of self-referencing interferometers such as the point diffraction interferometers. Alternatively wavefront gradient measuring instruments can be used such as the Hartmann-Shack sensors. Wavefront intensity and phase joint distributions can now be measured at the same time. This can provide in addition new methods to derive the modal content. A short review of the experimental problems in this area still looking for a practical solution will be given. Note from Publisher: This article contains the abstract and references only.

  6. Trans-dimensional inversion of microtremor array dispersion data with hierarchical autoregressive error models

    NASA Astrophysics Data System (ADS)

    Dettmer, Jan; Molnar, Sheri; Steininger, Gavin; Dosso, Stan E.; Cassidy, John F.

    2012-02-01

    This paper applies a general trans-dimensional Bayesian inference methodology and hierarchical autoregressive data-error models to the inversion of microtremor array dispersion data for shear wave velocity (vs) structure. This approach accounts for the limited knowledge of the optimal earth model parametrization (e.g. the number of layers in the vs profile) and of the data-error statistics in the resulting vs parameter uncertainty estimates. The assumed earth model parametrization influences estimates of parameter values and uncertainties due to different parametrizations leading to different ranges of data predictions. The support of the data for a particular model is often non-unique and several parametrizations may be supported. A trans-dimensional formulation accounts for this non-uniqueness by including a model-indexing parameter as an unknown so that groups of models (identified by the indexing parameter) are considered in the results. The earth model is parametrized in terms of a partition model with interfaces given over a depth-range of interest. In this work, the number of interfaces (layers) in the partition model represents the trans-dimensional model indexing. In addition, serial data-error correlations are addressed by augmenting the geophysical forward model with a hierarchical autoregressive error model that can account for a wide range of error processes with a small number of parameters. Hence, the limited knowledge about the true statistical distribution of data errors is also accounted for in the earth model parameter estimates, resulting in more realistic uncertainties and parameter values. Hierarchical autoregressive error models do not rely on point estimates of the model vector to estimate data-error statistics, and have no requirement for computing the inverse or determinant of a data-error covariance matrix. This approach is particularly useful for trans-dimensional inverse problems, as point estimates may not be representative of the state space that spans multiple subspaces of different dimensionalities. The order of the autoregressive process required to fit the data is determined here by posterior residual-sample examination and statistical tests. Inference for earth model parameters is carried out on the trans-dimensional posterior probability distribution by considering ensembles of parameter vectors. In particular, vs uncertainty estimates are obtained by marginalizing the trans-dimensional posterior distribution in terms of vs-profile marginal distributions. The methodology is applied to microtremor array dispersion data collected at two sites with significantly different geology in British Columbia, Canada. At both sites, results show excellent agreement with estimates from invasive measurements.

  7. What IRT Can and Cannot Do

    ERIC Educational Resources Information Center

    Glas, Cees A. W.

    2009-01-01

    This author states that, while the article by Gunter Maris and Timo Bechger ("On Interpreting the Model Parameters for the Three Parameter Logistic Model," this issue) is highly interesting, the interest is not so much in the practical implications, but rather in the issue of the meaning and role of statistical models in psychometrics and…

  8. Parallel optimization of signal detection in active magnetospheric signal injection experiments

    NASA Astrophysics Data System (ADS)

    Gowanlock, Michael; Li, Justin D.; Rude, Cody M.; Pankratius, Victor

    2018-05-01

    Signal detection and extraction requires substantial manual parameter tuning at different stages in the processing pipeline. Time-series data depends on domain-specific signal properties, necessitating unique parameter selection for a given problem. The large potential search space makes this parameter selection process time-consuming and subject to variability. We introduce a technique to search and prune such parameter search spaces in parallel and select parameters for time series filters using breadth- and depth-first search strategies to increase the likelihood of detecting signals of interest in the field of magnetospheric physics. We focus on studying geomagnetic activity in the extremely and very low frequency ranges (ELF/VLF) using ELF/VLF transmissions from Siple Station, Antarctica, received at Québec, Canada. Our technique successfully detects amplified transmissions and achieves substantial speedup performance gains as compared to an exhaustive parameter search. We present examples where our algorithmic approach reduces the search from hundreds of seconds down to less than 1 s, with a ranked signal detection in the top 99th percentile, thus making it valuable for real-time monitoring. We also present empirical performance models quantifying the trade-off between the quality of signal recovered and the algorithm response time required for signal extraction. In the future, improved signal extraction in scenarios like the Siple experiment will enable better real-time diagnostics of conditions of the Earth's magnetosphere for monitoring space weather activity.

  9. Rational Design of Molecular Gelator - Solvent Systems Guided by Solubility Parameters

    NASA Astrophysics Data System (ADS)

    Lan, Yaqi

    Self-assembled architectures, such as molecular gels, have attracted wide interest among chemists, physicists and engineers during the past decade. However, the mechanism behind self-assembly remains largely unknown and no capability exists to predict a priori whether a small molecule will gelate a specific solvent or not. The process of self-assembly, in molecular gels, is intricate and must balance parameters influencing solubility and those contrasting forces that govern epitaxial growth into axially symmetric elongated aggregates. Although the gelator-gelator interactions are of paramount importance in understanding gelation, the solvent-gelator specific (i.e., H-bonding) and nonspecific (dipole-dipole, dipole-induced and instantaneous dipole induced forces) intermolecular interactions are equally important. Solvent properties mediate the self-assembly of molecular gelators into their self-assembled fibrillar networks. Herein, solubility parameters of solvents, ranging from partition coefficients (logP), to Henry's law constants (HLC), to solvatochromic ET(30) parameters, to Kamlet-Taft parameters (beta, alpha and pi), to Hansen solubility parameters (deltap, deltad, deltah), etc., are correlated with the gelation ability of numerous classes of molecular gelators. Advanced solvent clustering techniques have led to the development of a priori tools that can identify the solvents that will be gelled and not gelled by molecular gelators. These tools will greatly aid in the development of novel gelators without solely relying on serendipitous discoveries.

  10. Finite Element Vibration Modeling and Experimental Validation for an Aircraft Engine Casing

    NASA Astrophysics Data System (ADS)

    Rabbitt, Christopher

    This thesis presents a procedure for the development and validation of a theoretical vibration model, applies this procedure to a pair of aircraft engine casings, and compares select parameters from experimental testing of those casings to those from a theoretical model using the Modal Assurance Criterion (MAC) and linear regression coefficients. A novel method of determining the optimal MAC between axisymmetric results is developed and employed. It is concluded that the dynamic finite element models developed as part of this research are fully capable of modelling the modal parameters within the frequency range of interest. Confidence intervals calculated in this research for correlation coefficients provide important information regarding the reliability of predictions, and it is recommended that these intervals be calculated for all comparable coefficients. The procedure outlined for aligning mode shapes around an axis of symmetry proved useful, and the results are promising for the development of further optimization techniques.

  11. Measurements of Excitation Functions and Line Polarizations for Electron Impact Excitation of the n = 2, 3 States of Atomic Hydrogen in the Energy Range 11 - 2000 eV

    NASA Technical Reports Server (NTRS)

    James, G. K.; Ajello, J. M.; Kanik, I.; Slevin, J.; Franklin, B.; Shemansky, D.

    1993-01-01

    The electron-atomic hydrogen scattering system is an important testing ground for theoretical models and has received a great deal of attention from experimentalists and theoreticians alike over the years. A complete description of the excitation process requires a knowledge of many different parameters, and experimental measurements of these parameters have been performed in various laboratories around the world. As far as total cross section data are concerned it has been noted that the discrepancy between the data of Long et al. and Williams for n = 2 excitations needs to be resolved in the interests of any further refinement of theory. We report new measurements of total cross sections and atomic line polarizations for both n=2 and n=3 excitations at energies from threshold to 2000 eV...

  12. Behavior of reinforcement SCC beams under elevated temperatures

    NASA Astrophysics Data System (ADS)

    Fathi, Hamoon; Farhang, Kianoosh

    2015-09-01

    This experimental study focuses on the behavior of heated reinforced concrete beams. Four types of concrete mixtures were used for the tested self-compacting concrete beams. A total of 72 reinforced concrete beams and 72 standard cylindrical specimens were tested. The compressive strength under uniaxial loading at 23 °C ranged from 30 to 45 MPa. The specimens were exposed to different temperatures. The test parameters of interest were the compressive strength and the temperature of the specimens. The effect of changes in the parameters was examined so as to control the behavior of the tested concrete and that of the reinforced concrete beam. The results indicated that flexibility and compressive strength of the reinforced concrete beams decreased at higher temperatures. Furthermore, heating beyond 400 °C produced greater variations in the structural behavior of the materials in both the cylindrical samples and the reinforced concrete beams.

  13. Materials Properties of Printable Edible Inks and Printing Parameters Optimization during 3D Printing: a review.

    PubMed

    Feng, Chunyan; Zhang, Min; Bhandari, Bhesh

    2018-06-01

    Interest in additive manufacture has grown significantly in recent years, driving a need for printable materials that can sustain high strains and still fulfill their function in applications such as tissue engineering, regenerative medicine field, food engineering and field of aerospace, etc. As an emerging and promising technology, 3Dprinting has attracted more and more attention with fast manipulation, reduce production cost, customize geometry, increase competitiveness and advantages in many hot research areas. Many researchers have done a lot of investigations on printable materials, ranging from a single material to composite material. Main content: This review focuses on the contents of printable edible inks. It also gathers and analyzes information on the effects of printable edible ink material properties on 3D print accuracy. In addition, it discusses the impact of printing parameters on accurate printing, and puts forward current challenges and recommendations for future research and development.

  14. Rapidly rotating neutron stars with a massive scalar field—structure and universal relations

    NASA Astrophysics Data System (ADS)

    Doneva, Daniela D.; Yazadjiev, Stoytcho S.

    2016-11-01

    We construct rapidly rotating neutron star models in scalar-tensor theories with a massive scalar field. The fact that the scalar field has nonzero mass leads to very interesting results since the allowed range of values of the coupling parameters is significantly broadened. Deviations from pure general relativity can be very large for values of the parameters that are in agreement with the observations. We found that the rapid rotation can magnify the differences several times compared to the static case. The universal relations between the normalized moment of inertia and quadrupole moment are also investigated both for the slowly and rapidly rotating cases. The results show that these relations are still EOS independent up to a large extend and the deviations from pure general relativity can be large. This places the massive scalar-tensor theories amongst the few alternative theories of gravity that can be tested via the universal I-Love-Q relations.

  15. A new fifth parameter for transverse isotropy III: reflection and transmission coefficients

    NASA Astrophysics Data System (ADS)

    Kawakatsu, Hitoshi

    2018-04-01

    The effect of the newly defined fifth parameter, ηκ, of transverse anisotropy to the reflection and transmission coefficients, especially for P-to-S and S-to-P conversion coefficients, is examined. While ηκ systematically affects the P-to-S and S-to-P conversions, in the incidence angle range of the practical interest of receiver function studies, the effect may be asymmetric in a sense that P-wave receiver function is affected more than S-receiver function in terms of amplitude. This asymmetry may help resolving ηκ via extensive receiver function analysis. It is also found that P-wave anisotropy significantly influences P-to-S and S-to-P conversion coefficients that complicates the interpretation of receiver functions, because, for isotropic media, we typically attribute the primary receiver function signals to S-wave velocity changes but not to P-wave changes.

  16. A time-dependent order parameter for ultrafast photoinduced phase transitions.

    PubMed

    Beaud, P; Caviezel, A; Mariager, S O; Rettig, L; Ingold, G; Dornes, C; Huang, S-W; Johnson, J A; Radovic, M; Huber, T; Kubacka, T; Ferrer, A; Lemke, H T; Chollet, M; Zhu, D; Glownia, J M; Sikorski, M; Robert, A; Wadati, H; Nakamura, M; Kawasaki, M; Tokura, Y; Johnson, S L; Staub, U

    2014-10-01

    Strongly correlated electron systems often exhibit very strong interactions between structural and electronic degrees of freedom that lead to complex and interesting phase diagrams. For technological applications of these materials it is important to learn how to drive transitions from one phase to another. A key question here is the ultimate speed of such phase transitions, and to understand how a phase transition evolves in the time domain. Here we apply time-resolved X-ray diffraction to directly measure the changes in long-range order during ultrafast melting of the charge and orbitally ordered phase in a perovskite manganite. We find that although the actual change in crystal symmetry associated with this transition occurs over different timescales characteristic of the many electronic and vibrational coordinates of the system, the dynamics of the phase transformation can be well described using a single time-dependent 'order parameter' that depends exclusively on the electronic excitation.

  17. New functionalities of Maillard reaction products as emulsifiers and encapsulating agents, and the processing parameters: a brief review.

    PubMed

    Lee, Yee-Ying; Tang, Teck-Kim; Phuah, Eng-Tong; Alitheen, Noorjahan Banu Mohamed; Tan, Chin-Ping; Lai, Oi-Ming

    2017-03-01

    Non-enzymatic browning has been a wide and interesting research area in the food industry, ranging from the complexity of the reaction to its applications in the food industry as well as its ever-debatable health effects. This review provides a new perspective to the Maillard reaction apart from its ubiquitous function in enhancing food flavour, taste and appearance. It focuses on the recent application of Maillard reaction products as an inexpensive and excellent source of emulsifiers as well as superior encapsulating matrices for the entrapment of bioactive compounds. Additionally, it will also discuss the latest approaches employed to perform the Maillard reaction as well as several important reaction parameters that need to be taken into consideration when conducting the Maillard reaction. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  18. Temperature dependence of conductivity measurement for conducting polymer

    NASA Astrophysics Data System (ADS)

    Gutierrez, Leandro; Duran, Jesus; Isah, Anne; Albers, Patrick; McDougall, Michael; Wang, Weining

    2014-03-01

    Conducting polymer-based solar cells are the newest generation solar cells. While research on this area has been progressing, the efficiency is still low because certain important parameters of the solar cell are still not well understood. It is of interest to study the temperature dependence of the solar cell parameters, such as conductivity of the polymer, open circuit voltage, and reverse saturation current to gain a better understanding on the solar cells. In this work, we report our temperature dependence of conductivity measurement using our in-house temperature-varying apparatus. In this project, we designed and built a temperature varying apparatus using a thermoelectric cooler module which gives enough temperature range as we need and costs much less than a cryostat. The set-up of the apparatus will be discussed. Temperature dependence of conductivity measurements for PEDOT:PSS films with different room-temperature conductivity will be compared and discussed. NJSGC-NASA Fellowship grant

  19. Quantum-statistical theory of microwave detection using superconducting tunnel junctions

    NASA Astrophysics Data System (ADS)

    Deviatov, I. A.; Kuzmin, L. S.; Likharev, K. K.; Migulin, V. V.; Zorin, A. B.

    1986-09-01

    A quantum-statistical theory of microwave and millimeter-wave detection using superconducting tunnel junctions is developed, with a rigorous account of quantum, thermal, and shot noise arising from fluctuation sources associated with the junctions, signal source, and matching circuits. The problem of the noise characterization in the quantum sensitivity range is considered and a general noise parameter Theta(N) is introduced. This parameter is shown to be an adequate figure of merit for most receivers of interest while some devices can require a more complex characterization. Analytical expressions and/or numerically calculated plots for Theta(N) are presented for the most promising detection modes including the parametric amplification, heterodyne mixing, and quadratic videodetection, using both the quasiparticle-current and the Cooper-pair-current nonlinearities. Ultimate minimum values of Theta(N) for each detection mode are compared and found to be in agreement with limitations imposed by the quantum-mechanical uncertainty principle.

  20. Development of Methods for the Determination of pKa Values

    PubMed Central

    Reijenga, Jetse; van Hoof, Arno; van Loon, Antonie; Teunissen, Bram

    2013-01-01

    The acid dissociation constant (pKa) is among the most frequently used physicochemical parameters, and its determination is of interest to a wide range of research fields. We present a brief introduction on the conceptual development of pKa as a physical parameter and its relationship to the concept of the pH of a solution. This is followed by a general summary of the historical development and current state of the techniques of pKa determination and an attempt to develop insight into future developments. Fourteen methods of determining the acid dissociation constant are placed in context and are critically evaluated to make a fair comparison and to determine their applications in modern chemistry. Additionally, we have studied these techniques in light of present trends in science and technology and attempt to determine how these trends might affect future developments in the field. PMID:23997574

  1. Adsorption of silver nanoparticles from aqueous solution on copper-based metal organic frameworks (HKUST-1).

    PubMed

    Conde-González, J E; Peña-Méndez, E M; Rybáková, S; Pasán, J; Ruiz-Pérez, C; Havel, J

    2016-05-01

    Silver nanoparticles (AgNP) are emerging pollutants. The use of novel materials such as Cu-(benzene 1,3,5-tricarboxylate, BTC) Metal-Organic Framework (MOFs), for AgNP adsorption and their removal from aqueous solutions has been studied. The effect of different parameters was followed and isotherm model was suggested. MOFs adsorbed fast and efficiently AgNP in the range C0 < 10 mg L(-1), being Freundlich isotherm (R = 0.993) these data fitted to. Among studied parameters a remarkable effect of chloride on sorption was found, thus their possible interactions were considered. The high adsorption efficiency of AgNP was achieved and it was found to be very fast. The feasibility of adsorption on Cu-(BTC) was proved in spiked waters. The results showed the potential interest of new material as adsorbent for removing AgNP from environment. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Surface characteristics modeling and performance evaluation of urban building materials using LiDAR data.

    PubMed

    Li, Xiaolu; Liang, Yu

    2015-05-20

    Analysis of light detection and ranging (LiDAR) intensity data to extract surface features is of great interest in remote sensing research. One potential application of LiDAR intensity data is target classification. A new bidirectional reflectance distribution function (BRDF) model is derived for target characterization of rough and smooth surfaces. Based on the geometry of our coaxial full-waveform LiDAR system, the integration method is improved through coordinate transformation to establish the relationship between the BRDF model and intensity data of LiDAR. A series of experiments using typical urban building materials are implemented to validate the proposed BRDF model and integration method. The fitting results show that three parameters extracted from the proposed BRDF model can distinguish the urban building materials from perspectives of roughness, specular reflectance, and diffuse reflectance. A comprehensive analysis of these parameters will help characterize surface features in a physically rigorous manner.

  3. Effects of strain on the half-metallicity and spin gapless feature of Ti2YSi (Y = Fe, Co) alloys

    NASA Astrophysics Data System (ADS)

    Fan, Xiaoguang; Li, Jincheng; Jin, Yingjiu

    2018-05-01

    Half-metals and spin gapless semiconductors (SGSs), which exhibit 100% spin polarization at the Fermi level, are considered important candidates for spintronics. Using first-principles calculations, we have investigated the effects of uniform strain and tetragonal distortion on the half-metallicity and spin gapless feature of inverse Heusler Ti2YSi (Y = Fe and Co) alloys. Results show that for uniform strains, the half-metallicity occurs in the ranges of lattice parameters from 5.938 Å to 6.535 Å for Ti2FeSi and from 5.924 Å to 6.840 Å for Ti2CoSi. Tetragonal distortions over the ranges of ‑2.0% to +2.5% and ‑2.6% to +4.1% could destroy the half-metallicity for Ti2FeSi and Ti2CoSi, respectively. On the other hand, Ti2CoSi is an SGS at lattice constants of 5.968-6.023 Å. An interesting finding is that Ti2CoSi reproduces the SGS character with increasing the lattice parameters to 6.784-6.840 Å. Small tetragonal distortions with ±0.2% will destroy the SGS character of Ti2CoSi.

  4. Phantom energy mediates a long-range repulsive force.

    PubMed

    Amendola, Luca

    2004-10-29

    Scalar field models with nonstandard kinetic terms have been proposed in the context of k inflation, of Born-Infeld Lagrangians, of phantom energy and, more in general, of low-energy string theory. In general, scalar fields are expected to couple to matter inducing a new interaction. In this Letter I derive the cosmological perturbation equations and the Yukawa correction to gravity for such general models. I find three interesting results: first, when the field behaves as phantom energy (equation of state less than -1), then the coupling strength is negative, inducing a long-range repulsive force; second, the dark-energy field might cluster on astrophysical scales; third, applying the formalism to a Brans-Dicke theory with a general kinetic term it is shown that its Newtonian effects depend on a single parameter that generalizes the Brans-Dicke constant.

  5. Efficiency of filtering materials used in respiratory protective devices against nanoparticles.

    PubMed

    Brochocka, Agnieszka; Makowski, Krzysztof; Majchrzycka, Katarzyna; Grzybowski, Piotr

    2013-01-01

    The basic aim of this research was to establish the efficiency of filtering materials widely used in respiratory protection devices with particular interest in their porosity, degree of electric and changeable process parameters, such as the flow rate of the test nanoaerosol and the size range of nanoparticles. Tests were carried out with an NaCl solid aerosol of 3.2 × 105 particles/cm3 for the range of particle size of 7-270 nm, at aerosol flow rate of 1800, 2700, 3600, 4500 and 5400 L/h. The tests showed that electrospun nonwovens were the most effective filtering materials for nanoparticles over 20 nm. Melt-blown electret nonwovens with lower porosity than electrospun nonwovens had higher values of penetration of 1%-4%. Those materials provided very efficient protection against nanoparticles of certain sizes only.

  6. Analysis of optical scheme for medium-range directed energy laser weapon system

    NASA Astrophysics Data System (ADS)

    Jabczyński, Jan K.; Kaśków, Mateusz; Gorajek, Łukasz; Kopczyński, Krzysztof

    2017-10-01

    The relations between range of operation and aperture of laser weapon system were investigated, taking into account diffraction and technical limitations as beam quality, accuracy of point tracking, technical quality of optical train, etc. As a result for the medium ranges of 1 - 2 km we restricted the analysis to apertures not wider than 150 mm and the optical system without adaptive optics. To choose the best laser beam shape, the minimization of aperture losses and thermooptical effects inside optics as well as the effective width of laser beam in far field should be taken into account. We have analyzed theoretically such a problem for the group of a few most interesting from that point of view profiles including for reference two limiting cases of Gaussian beam and `top hat' profile. We have found that the most promising is the SuperGaussian profile of index p = 2 for which the surfaces of beam shaper elements can be manufactured in the acceptable cost-effective way and beam quality does not decrease noticeably. Further, we have investigated the thermo-optic effects on the far field parameters of Gaussian and `top hat' beams to determine the influence of absorption in optical elements on beam quality degradation. The simplified formulae were derived for beam quality measures (parameter M2 and Strehl ratio) which enables to estimate the influence of absorption losses on degradation of beam quality.

  7. Fractional Brownian motion time-changed by gamma and inverse gamma process

    NASA Astrophysics Data System (ADS)

    Kumar, A.; Wyłomańska, A.; Połoczański, R.; Sundar, S.

    2017-02-01

    Many real time-series exhibit behavior adequate to long range dependent data. Additionally very often these time-series have constant time periods and also have characteristics similar to Gaussian processes although they are not Gaussian. Therefore there is need to consider new classes of systems to model these kinds of empirical behavior. Motivated by this fact in this paper we analyze two processes which exhibit long range dependence property and have additional interesting characteristics which may be observed in real phenomena. Both of them are constructed as the superposition of fractional Brownian motion (FBM) and other process. In the first case the internal process, which plays role of the time, is the gamma process while in the second case the internal process is its inverse. We present in detail their main properties paying main attention to the long range dependence property. Moreover, we show how to simulate these processes and estimate their parameters. We propose to use a novel method based on rescaled modified cumulative distribution function for estimation of parameters of the second considered process. This method is very useful in description of rounded data, like waiting times of subordinated processes delayed by inverse subordinators. By using the Monte Carlo method we show the effectiveness of proposed estimation procedures. Finally, we present the applications of proposed models to real time series.

  8. Reassessment of ABO blood group, sex, and age on laboratory parameters used to diagnose von Willebrand disorder: potential influence on the diagnosis vs the potential association with risk of thrombosis.

    PubMed

    Favaloro, Emmanuel J; Soltani, Soma; McDonald, Jane; Grezchnik, Ella; Easton, Leanne; Favaloro, James W C

    2005-12-01

    We reassessed the influence of ABO blood group, sex, and age on plasma levels of von Willebrand factor (vWF) antigen, vWF:ristocetin cofactor, vWF:collagen binding assay, and factor VIII coagulant (FVIII:C). Data show that levels of vWF and FVIII:C increase with increasing age (P < .001 for all parameters) and that the ABO blood group influences plasma levels such that O group levels are significantly less than non-O group levels. There was no significant association with sex and Rh status. The selection of normal ranges based on ABO blood groups may influence the clinical diagnosis of von Willebrand disease (vWD) but might not be clinically relevant or help identify people at increased risk of bleeding. Differences in ABO-related ranges were more extensive at the high end of the ranges. This is of particular interest because high levels of vWF and FVIII are associated with thrombosis risk, and an ABO relationship also has been described. O group individuals may or may not be at greater risk for bleeding (they have lower levels of vWF and FVIII:C) and are more likely to be diagnosed with vWD. It also is possible that O group status may be protective for thrombosis.

  9. Electrical and magnetic properties of rock and soil

    USGS Publications Warehouse

    Scott, J.H.

    1983-01-01

    Field and laboratory measurements have been made to determine the electrical conductivity, dielectric constant, and magnetic permeability of rock and soil in areas of interest in studies of electromagnetic pulse propagation. Conductivity is determined by making field measurements of apparent resisitivity at very low frequencies (0-20 cps), and interpreting the true resistivity of layers at various depths by curve-matching methods. Interpreted resistivity values are converted to corresponding conductivity values which are assumed to be applicable at 10^2 cps, an assumption which is considered valid because the conductivity of rock and soil is nearly constant at frequencies below 10^2 cps. Conductivity is estimated at higher frequencies (up to 10^6 cps) by using statistical correlations of three parameters obtained from laboratory measurements of rock and soil samples: conductivity at 10^2 cps, frequency and conductivity measured over the range 10^2 to 10^6 cps. Conductivity may also be estimated in this frequency range by using field measurements of water content and correlations of laboratory sample measurements of the three parameters: water content, frequency, and conductivity measured over the range 10^2 to 10^6 cps. This method is less accurate because nonrandom variation of ion concentration in natural pore water introduces error. Dielectric constant is estimated in a similar manner from field-derived conductivity values applicable at 10^2 cps and statistical correlations of three parameters obtained from laboratory measurements of samples: conductivity measured at 10^2 cps, frequency, and dielectric constant measured over the frequency range 10^2 to 10^6 cps. Dielectric constant may also be estimated from field measurements of water content and correlations of laboratory sample measurements of the three parameters: water content, frequency, and dielectric constant measured from 10^2 to 10^6 cps, but again, this method is less accurate because of variation of ion concentration of pore water. Special laboratory procedures are used to measure conductivity and dielectric constant of rock and soil samples. Electrode polarization errors are minimized by using an electrode system that is electrochemically reversible-with ions in pore water.

  10. Medical smart textiles based on fiber optic technology: an overview.

    PubMed

    Massaroni, Carlo; Saccomandi, Paola; Schena, Emiliano

    2015-04-13

    The growing interest in the development of smart textiles for medical applications is driven by the aim to increase the mobility of patients who need a continuous monitoring of such physiological parameters. At the same time, the use of fiber optic sensors (FOSs) is gaining large acceptance as an alternative to traditional electrical and mechanical sensors for the monitoring of thermal and mechanical parameters. The potential impact of FOSs is related to their good metrological properties, their small size and their flexibility, as well as to their immunity from electromagnetic field. Their main advantage is the possibility to use textile based on fiber optic in a magnetic resonance imaging environment, where standard electronic sensors cannot be employed. This last feature makes FOSs suitable for monitoring biological parameters (e.g., respiratory and heartbeat monitoring) during magnetic resonance procedures. Research interest in combining FOSs and textiles into a single structure to develop wearable sensors is rapidly growing. In this review we provide an overview of the state-of-the-art of textiles, which use FOSs for monitoring of mechanical parameters of physiological interest. In particular we briefly describe the working principle of FOSs employed in this field and their relevant advantages and disadvantages. Also reviewed are their applications for the monitoring of mechanical parameters of physiological interest.

  11. Medical Smart Textiles Based on Fiber Optic Technology: An Overview

    PubMed Central

    Massaroni, Carlo; Saccomandi, Paola; Schena, Emiliano

    2015-01-01

    The growing interest in the development of smart textiles for medical applications is driven by the aim to increase the mobility of patients who need a continuous monitoring of such physiological parameters. At the same time, the use of fiber optic sensors (FOSs) is gaining large acceptance as an alternative to traditional electrical and mechanical sensors for the monitoring of thermal and mechanical parameters. The potential impact of FOSs is related to their good metrological properties, their small size and their flexibility, as well as to their immunity from electromagnetic field. Their main advantage is the possibility to use textile based on fiber optic in a magnetic resonance imaging environment, where standard electronic sensors cannot be employed. This last feature makes FOSs suitable for monitoring biological parameters (e.g., respiratory and heartbeat monitoring) during magnetic resonance procedures. Research interest in combining FOSs and textiles into a single structure to develop wearable sensors is rapidly growing. In this review we provide an overview of the state-of-the-art of textiles, which use FOSs for monitoring of mechanical parameters of physiological interest. In particular we briefly describe the working principle of FOSs employed in this field and their relevant advantages and disadvantages. Also reviewed are their applications for the monitoring of mechanical parameters of physiological interest. PMID:25871010

  12. Electrostatic swelling of bicontinuous cubic lipid phases.

    PubMed

    Tyler, Arwen I I; Barriga, Hanna M G; Parsons, Edward S; McCarthy, Nicola L C; Ces, Oscar; Law, Robert V; Seddon, John M; Brooks, Nicholas J

    2015-04-28

    Lipid bicontinuous cubic phases have attracted enormous interest as bio-compatible scaffolds for use in a wide range of applications including membrane protein crystallisation, drug delivery and biosensing. One of the major bottlenecks that has hindered exploitation of these structures is an inability to create targeted highly swollen bicontinuous cubic structures with large and tunable pore sizes. In contrast, cubic structures found in vivo have periodicities approaching the micron scale. We have been able to engineer and control highly swollen bicontinuous cubic phases of spacegroup Im3m containing only lipids by (a) increasing the bilayer stiffness by adding cholesterol and (b) inducing electrostatic repulsion across the water channels by addition of anionic lipids to monoolein. By controlling the composition of the ternary mixtures we have been able to achieve lattice parameters up to 470 Å, which is 5 times that observed in pure monoolein and nearly twice the size of any lipidic cubic phase reported previously. These lattice parameters significantly exceed the predicted maximum swelling for bicontinuous cubic lipid structures, which suggest that thermal fluctuations should destroy such phases for lattice parameters larger than 300 Å.

  13. Theory of structure formation in snowfields motivated by penitentes, suncups, and dirt cones.

    PubMed

    Betterton, M D

    2001-05-01

    Penitentes and suncups are structures formed as snow melts, typically high in the mountains. When the snow is dirty, dirt cones and other structures can form instead. Building on previous field observations and experiments, this paper presents a theory of ablation morphologies, and the role of surface dirt in determining the structures formed. The glaciological literature indicates that sunlight, heating from air, and dirt all play a role in the formation of structure on an ablating snow surface. The present paper formulates a minimal model for the formation of ablation morphologies as a function of measurable parameters and considers the linear stability of this model. The dependence of ablation morphologies on weather conditions and initial dirt thickness is studied, focusing on the initial growth of perturbations away from a flat surface. We derive a single-parameter expression for the melting rate as a function of dirt thickness, which agrees well with a set of measurements by Driedger. An interesting result is the prediction of a dirt-induced traveling instability for a range of parameters.

  14. The effect of military load carriage on 3-D lower limb kinematics and spatiotemporal parameters.

    PubMed

    Birrell, Stewart A; Haslam, Roger A

    2009-10-01

    The 3-D gait analysis of military load carriage is not well represented, if at all, within the available literature. This study collected 3-D lower limb kinematics and spatiotemporal parameters in order to assess the subsequent impact of carrying loads in a backpack of up to 32 kg. Results showed the addition of load significantly decreased the range of motion of flexion/extension of the knee and pelvic rotation. Also seen were increases in adduction/abduction and rotation of the hip and pelvis tilt. No changes to ankle kinematics were observed. Alterations to the spatiotemporal parameters of gait were also of considerable interest, namely, an increase in double support and a decrease in preferred stride length as carried load increased. Analysing kinematics during military or recreational load carriage broadens the knowledge regarding the development of exercise-related injuries, while helping to inform the human-centred design process for future load carrying systems. The importance of this study is that limited available research has investigated 3-D lower limb joint kinematics when carrying loads.

  15. A parameter-free variational coupling approach for trimmed isogeometric thin shells

    NASA Astrophysics Data System (ADS)

    Guo, Yujie; Ruess, Martin; Schillinger, Dominik

    2017-04-01

    The non-symmetric variant of Nitsche's method was recently applied successfully for variationally enforcing boundary and interface conditions in non-boundary-fitted discretizations. In contrast to its symmetric variant, it does not require stabilization terms and therefore does not depend on the appropriate estimation of stabilization parameters. In this paper, we further consolidate the non-symmetric Nitsche approach by establishing its application in isogeometric thin shell analysis, where variational coupling techniques are of particular interest for enforcing interface conditions along trimming curves. To this end, we extend its variational formulation within Kirchhoff-Love shell theory, combine it with the finite cell method, and apply the resulting framework to a range of representative shell problems based on trimmed NURBS surfaces. We demonstrate that the non-symmetric variant applied in this context is stable and can lead to the same accuracy in terms of displacements and stresses as its symmetric counterpart. Based on our numerical evidence, the non-symmetric Nitsche method is a viable parameter-free alternative to the symmetric variant in elastostatic shell analysis.

  16. James Clerk Maxwell Prize Address: High Intensity Laser Propagation and Interactions

    NASA Astrophysics Data System (ADS)

    Sprangle, Phillip

    2013-10-01

    High intensity laser radiation sources cover a wide range of parameters, e.g., peak powers from tera to peta watts, pulse lengths from pico to femto seconds, repetition rates ranging from kilo to mega hertz and average powers of many tens of watts. This talk will cover, among other things, some of the unique physical processes which result when high intensity laser radiation interacts with gases and plasmas. One of the interesting topics to be discussed is the propagation of these laser pulses in a turbulent atmosphere which results in a multitude of coupled linear and nonlinear processes including filamentation and scintillation. Phase conjugation techniques to reduce the effects of atmospheric turbulence (scintillation) will be described. This talk will also discuss a range of potential applications of these high intensity lasers, including: electron acceleration in spatially periodic and tapered plasma channels, detection of radioactive material using electromagnetic signatures, atmospheric lasing of N2 molecules, as well as incoherent and coherent x-ray generation mechanisms. Research supported by NRL, ONR and UMD.

  17. Modal density of rectangular structures in a wide frequency range

    NASA Astrophysics Data System (ADS)

    Parrinello, A.; Ghiringhelli, G. L.

    2018-04-01

    A novel approach to investigate the modal density of a rectangular structure in a wide frequency range is presented. First, the modal density is derived, in the whole frequency range of interest, on the basis of sound transmission through the infinite counterpart of the structure; then, it is corrected by means of the low-frequency modal behavior of the structure, taking into account actual size and boundary conditions. A statistical analysis reveals the connection between the modal density of the structure and the transmission of sound through its thickness. A transfer matrix approach is used to compute the required acoustic parameters, making it possible to deal with structures having arbitrary stratifications of different layers. A finite element method is applied on coarse grids to derive the first few eigenfrequencies required to correct the modal density. Both the transfer matrix approach and the coarse grids involved in the finite element analysis grant high efficiency. Comparison with alternative formulations demonstrates the effectiveness of the proposed methodology.

  18. Frequency pulling in a low-voltage medium-power gyrotron

    NASA Astrophysics Data System (ADS)

    Luo, Li; Du, Chao-Hai; Huang, Ming-Guang; Liu, Pu-Kun

    2018-04-01

    Many recent biomedical applications use medium-power frequency-tunable terahertz (THz) sources, such as sensitivity-enhanced nuclear magnetic resonance, THz imaging, and biomedical treatment. As a promising candidate, a low-voltage gyrotron can generate watt-level, continuous THz-wave radiation. In particular, the frequency-pulling effect in a gyrotron, namely, the effect of the electron beam parameters on the oscillation frequency, can be used to tune the operating frequency. Most previous investigations used complicated and time-consuming gyrotron nonlinear theory to study the influence of many beam parameters on the interaction performance. While gyrotron linear theory investigation demonstrates the advantages of rapidly and clearly revealing the physical influence of individual key beam parameters on the overall system performance, this paper demonstrates systematically the use of gyrotron linear theory to study the frequency-pulling effect in a low-voltage gyrotron with either a Gaussian or a sinusoidal axial-field profile. Furthermore, simulations of a gyrotron operating in the first axial mode are carried out in the framework of nonlinear theory as a contrast. Close agreement is achieved between the two theories. Besides, some interesting results are obtained. In a low-current sinusoidal-profile cavity, the ranges of frequency variation for different axial modes are isolated from each other, and the frequency tuning bandwidth for each axial mode increases by increasing either the beam voltage or pitch factor. Lowering the voltage, the total tuning ranges are squeezed and become concentrated. However, the isolated frequency regions of each axial mode cannot be linked up unless the beam current is increased, meaning that higher current operation is the key to achieving a wider and continuous tuning frequency range. The results presented in this paper can provide a reference for designing a broadband low-voltage gyrotron.

  19. Vapor hydrogen peroxide as alternative to dry heat microbial reduction

    NASA Astrophysics Data System (ADS)

    Chung, S.; Kern, R.; Koukol, R.; Barengoltz, J.; Cash, H.

    2008-09-01

    The Jet Propulsion Laboratory (JPL), in conjunction with the NASA Planetary Protection Officer, has selected vapor phase hydrogen peroxide (VHP) sterilization process for continued development as a NASA approved sterilization technique for spacecraft subsystems and systems. The goal was to include this technique, with an appropriate specification, in NASA Procedural Requirements 8020.12 as a low-temperature complementary technique to the dry heat sterilization process. The VHP process is widely used by the medical industry to sterilize surgical instruments and biomedical devices, but high doses of VHP may degrade the performance of flight hardware, or compromise material compatibility. The goal for this study was to determine the minimum VHP process conditions for planetary protection acceptable microbial reduction levels. Experiments were conducted by the STERIS Corporation, under contract to JPL, to evaluate the effectiveness of vapor hydrogen peroxide for the inactivation of the standard spore challenge, Geobacillus stearothermophilus. VHP process parameters were determined that provide significant reductions in spore viability while allowing survival of sufficient spores for statistically significant enumeration. In addition to the obvious process parameters of interest: hydrogen peroxide concentration, number of injection cycles, and exposure duration, the investigation also considered the possible effect on lethality of environmental parameters: temperature, absolute humidity, and material substrate. This study delineated a range of test sterilizer process conditions: VHP concentration, process duration, a process temperature range for which the worst case D-value may be imposed, a process humidity range for which the worst case D-value may be imposed, and the dependence on selected spacecraft material substrates. The derivation of D-values from the lethality data permitted conservative planetary protection recommendations.

  20. Fragmented red cells reference range (Sysmex XN(®) automated blood cell counter).

    PubMed

    Lesesve, Jean-François; Daigney, Amandine; Henry, Sylvain; Speyer, Elodie

    2015-01-01

    Fragmented red cells (FRCs) is a new parameter automatedly determined by recent blood cell counters. Their count might be of interest because FRCs are supposed to reflect schistocytes counts measured on a stained peripheral blood smear observed under the microscope. But FRCs depend from the technical procedure used to detect them and thus reference ranges are device-dependent. The XN-9000(®) is one of the last model from Sysmex series. We aimed to establish reference range for FRCs, from 2389 controls. The mean ± SD was 0.32% ± 0.81, the median 0.02% (95% confidence interval ot the mean: 0.29-0.35%). We observed that the percentage of red blood cells with less than 17 pg of hemoglobin content (Hypo-He) was correlated to FRC increase, Hypo-He increase resulting in spurious FRCs majoration. FRCs reference range should be useful for: 1) laboratory staff in order to select which blood smears to check optically; 2) Sysmex company to set-up more optimal rules proposed with the counter (automated making of blood smear).

  1. Fragmented red cells reference range for the Sysmex XN®-series of automated blood cell counters.

    PubMed

    Lesesve, J-F; Speyer, E; Perol, J-P

    2015-10-01

    Fragmented red cells (FRCs) are a new parameter determined automatically by the latest generation of blood cell counters. FRC counts may be of interest as they may reflect schistocyte counts measured on a stained peripheral blood smear observed under the microscope. However, FRC counts depend on the technical procedure used to detect them so that reference ranges are device dependent. The XN-9000® is one of the latest models from the Sysmex series of analysers. We aimed to establish a reference range for FRCs based on 1366 normal patient samples. The mean ± SD was 0.14 ± 0.35% and the median was 0% (95% confidence interval of the mean: 0.12-0.16%). We observed that the percentage of red blood cells with <17 pg of haemoglobin content (Hypo-He) was correlated to an FRC increase and that flagged results relating to red blood cells, reticulocytes or platelets might have presented with artefactually increased FRCs. The FRCs reference range (healthy subjects) should be useful for laboratory staff for selecting which blood smears to check optically. © 2015 John Wiley & Sons Ltd.

  2. Effects of abiotic factors on the nanostructure of diatom frustules-ranges and variability.

    PubMed

    Su, Yanyan; Lundholm, Nina; Ellegaard, Marianne

    2018-05-26

    The intricate patterning of diatom silica frustules at nanometer-to-micrometer scales makes them of interest for a wide range of industrial applications. For some of these applications, a specific size range in nanostructure is required and may be achieved by selecting species with the desired properties. However, as all biological materials, diatom frustules exhibit variability in their morphological parameters and this variability can to some extent be affected and controlled by environmental conditions. In this review, we explore the effects of different environmental factors including salinity, heavy metals, temperature, pH, extracellular Si(OH) 4 or Ge(OH) 4 concentration, light regime, UV irradiance, long-term cultivation, and biotic factors on the nanostructure of diatom frustules. This compilation of studies illustrates that it is possible to affect the nanostructure of diatom frustules in vivo by controlling different environmental factors as well as by direct chemical modification of frustules. We compare these methods and present examples of how these changes affect the range of variability as well as comparing the magnitude of size changes of the most promising methods.

  3. Laser diode stack beam shaping for efficient and compact long-range laser illuminator design

    NASA Astrophysics Data System (ADS)

    Lutz, Y.; Poyet, J. M.

    2014-04-01

    Laser diode stacks are interesting laser sources for active imaging illuminators. They allow the accumulation of large amounts of energy in multi-pulse mode, which is best suited for long-range image recording. Even when the laser diode stacks are equipped with fast-axis collimation (FAC) and slow-axis collimation (SAC) micro-lenses, their beam parameter products BPP are not compatible with direct use in highly efficient and compact illuminators. This is particularly true when narrow divergences are required such as for long-range applications. A solution to overcome these difficulties is to enhance the poor slow-axis BPP by virtually restacking the laser diode stack. We present a beam shaping and homogenization method that is low-cost and efficient and has low alignment sensitivity. After conducting simulations, we have realized and characterized the illuminator. A compact long-range laser illuminator has been set up with a divergence of 3.5×2.6 mrad and a global efficiency of 81%. Here, a projection lens with a clear aperture of 62 mm and a focal length of 571 mm was used.

  4. New Data Products Available at the IRIS Data Management Center

    NASA Astrophysics Data System (ADS)

    Ahern, T.; Casey, R.; Kamb, L.; Zeleznik, M.; Ammon, C. J.

    2007-12-01

    With USArray data processing and services in full production, the IRIS Data Management Center (DMC) has developed an online tool to function as a library for products derived from raw USArray observations as well as other catalogs with broad interest produced and supplied by the geoscience community. The service, called SPADE, is a flexible, annotated cataloging system for storing heterogeneous data products supplied by registered providers. SPADE includes a web interface that allows users to search across the spectrum of varied data products using geographic, temporal, and/or keyword parameters to locate products of specific interest. In addition to cooperative product submissions from outside institutions, the IRIS DMC is collaborating and developing frameworks to produce and to provide interesting products that take advantage of data from USArray sensors. These products are automatically produced in near- real time following interesting seismic events, and broaden the range of information that IRIS delivers to the geoscience community. In this presentation we will demonstrate the SPADE query interface and present examples of the available data products such as Global Centroid Moment Tensor solutions from Harvard and Columbia Universities, historic earthquake data scanned from select WWSSN film chips, as well as IRIS-produced seismic record sections, and ground-motion animations derived from Transportable Array observations.

  5. A convenient and accurate wide-range parameter relationship between Buckingham and Morse potential energy functions

    NASA Astrophysics Data System (ADS)

    Lim, Teik-Cheng; Dawson, James Alexander

    2018-05-01

    This study explores the close-range, short-range and long-range relationships between the parameters of the Morse and Buckingham potential energy functions. The results show that the close-range and short-range relationships are valid for bond compression and for very small changes in bond length, respectively, while the long-range relationship is valid for bond stretching. A wide-range relationship is proposed to combine the comparative advantages of the close-range, short-range and long-range parameter relationships. The wide-range relationship is useful for replacing the close-range, short-range and long-range parameter relationships, thereby preventing the undesired effects of potential energy jumps resulting from functional switching between the close-range, short-range and long-range interaction energies.

  6. Shigaraki UAV-Radar Experiment (ShUREX): overview of the campaign with some preliminary results

    NASA Astrophysics Data System (ADS)

    Kantha, Lakshmi; Lawrence, Dale; Luce, Hubert; Hashiguchi, Hiroyuki; Tsuda, Toshitaka; Wilson, Richard; Mixa, Tyler; Yabuki, Masanori

    2017-12-01

    The Shigaraki unmanned aerial vehicle (UAV)-Radar Experiment (ShUREX) is an international (USA-Japan-France) observational campaign, whose overarching goal is to demonstrate the utility of small, lightweight, inexpensive, autonomous UAVs in probing and monitoring the lower troposphere and to promote synergistic use of UAVs and very high frequency (VHF) radars. The 2-week campaign lasting from June 1 to June 14, 2015, was carried out at the Middle and Upper Atmosphere (MU) Observatory in Shigaraki, Japan. During the campaign, the DataHawk UAV, developed at the University of Colorado, Boulder, and equipped with high-frequency response cold wire and pitot tube sensors (as well as an iMET radiosonde), was flown near and over the VHF-band MU radar. Measurements in the atmospheric column in the immediate vicinity of the radar were obtained. Simultaneous and continuous operation of the radar in range imaging mode enabled fine-scale structures in the atmosphere to be visualized by the radar. It also permitted the UAV to be commanded to sample interesting structures, guided in near real time by the radar images. This overview provides a description of the ShUREX campaign and some interesting but preliminary results of the very first simultaneous and intensive probing of turbulent structures by UAVs and the MU radar. The campaign demonstrated the validity and utility of the radar range imaging technique in obtaining very high vertical resolution ( 20 m) images of echo power in the atmospheric column, which display evolving fine-scale atmospheric structures in unprecedented detail. The campaign also permitted for the very first time the evaluation of the consistency of turbulent kinetic energy dissipation rates in turbulent structures inferred from the spectral broadening of the backscattered radar signal and direct, in situ measurements by the high-frequency response velocity sensor on the UAV. The data also enabled other turbulence parameters such as the temperature structure function parameter {C}_T^2 and refractive index structure function parameter {C}_n^2 to be measured by sensors on the UAV, along with radar-inferred refractive index structure function parameter {C}_{n,radar}^2 . The comprehensive dataset collected during the campaign (from the radar, the UAV, the boundary layer lidar, the ceilometer, and radiosondes) is expected to help obtain a better understanding of turbulent atmospheric structures, as well as arrive at a better interpretation of the radar data.

  7. A realistic intersecting D6-brane model after the first LHC run

    NASA Astrophysics Data System (ADS)

    Li, Tianjun; Nanopoulos, D. V.; Raza, Shabbar; Wang, Xiao-Chuan

    2014-08-01

    With the Higgs boson mass around 125 GeV and the LHC supersymmetry search constraints, we revisit a three-family Pati-Salam model from intersecting D6-branes in Type IIA string theory on the T 6/(ℤ2 × ℤ2) orientifold which has a realistic phenomenology. We systematically scan the parameter space for μ < 0 and μ > 0, and find that the gravitino mass is generically heavier than about 2 TeV for both cases due to the Higgs mass low bound 123 GeV. In particular, we identify a region of parameter space with the electroweak fine-tuning as small as Δ EW ~ 24-32 (3-4%). In the viable parameter space which is consistent with all the current constraints, the mass ranges for gluino, the first two-generation squarks and sleptons are respectively [3, 18] TeV, [3, 16] TeV, and [2, 7] TeV. For the third-generation sfermions, the light stop satisfying 5 σ WMAP bounds via neutralino-stop coannihilation has mass from 0.5 to 1.2 TeV, and the light stau can be as light as 800 GeV. We also show various coannihilation and resonance scenarios through which the observed dark matter relic density is achieved. Interestingly, the certain portions of parameter space has excellent t- b- τ and b- τ Yukawa coupling unification. Three regions of parameter space are highlighted as well where the dominant component of the lightest neutralino is a bino, wino or higgsino. We discuss various scenarios in which such solutions may avoid recent astrophysical bounds in case if they satisfy or above observed relic density bounds. Prospects of finding higgsino-like neutralino in direct and indirect searches are also studied. And we display six tables of benchmark points depicting various interesting features of our model. Note that the lightest neutralino can be heavy up to 2.8 TeV, and there exists a natural region of parameter space from low-energy fine-tuning definition with heavy gluino and first two-generation squarks/sleptons, we point out that the 33 TeV and 100 TeV proton-proton colliders are indeed needed to probe our D-brane model.

  8. Modeling of termokinetic oscillations at partial oxidation of methane

    NASA Astrophysics Data System (ADS)

    Arutyunov, A. V.; Belyaev, A. A.; Inovenkov, I. N.; Nefedov, V. V.

    2017-12-01

    Partial oxidation of natural gas at moderate temperatures below 1500 K has significant interest for a number of industrial applications. But such processes can proceed at different unstable regimes including oscillating modes. Nonlinear phenomena at partial oxidation of methane were observed at different conditions. The investigation of the complex nonlinear system of equations that describes this process is a real method to insure its stability at industrial conditions and, at the same time, is an effective tool for its further enhancement. Numerical analysis of methane oxidation kinetics in the continuous stirred-tank reactor, with the use of detailed kinetic model has shown the possibility of the appearance of oscillating modes in the appropriate range of reaction parameters that characterize the composition, pressure, reagents flow, thermophysical features of the system, and geometry of the reactor. The appearance of oscillating modes is connected both with the reaction kinetics, heat release and sink and reagents introduction and removing. At that, oscillations appear only at a limited range of parameters, but can be accompanied by significant change in the yield of products. We have determined the range of initial temperature and pressure at which oscillations can be observed, if all other parameters remained fixed. The boundaries of existence of oscillations on the phase plane were calculated. It was shown that depending on the position inside the oscillation region the oscillations have different frequency and amplitude. It was reviled the role of heat exchange with the environment: at the absence of heat exchange the oscillating modes are impossible. In the vicinity of the boundary of phase range, where oscillations exist, significant change of concentration of some products were observed, for example, that of CO2, which in this case one of the principal products is. At that, insignificant increase in pressure not only change the character of CO2 behaving with time, but as well lead to significant increase of its mole fraction simultaneously twice decreasing the mole fraction of CO.

  9. Generation of Requirements for Simulant Measurements

    NASA Technical Reports Server (NTRS)

    Rickman, D. L.; Schrader, C. M.; Edmunson, J. E.

    2010-01-01

    This TM presents a formal, logical explanation of the parameters selected for the figure of merit (FoM) algorithm. The FoM algorithm is used to evaluate lunar regolith simulant. The objectives, requirements, assumptions, and analysis behind the parameters are provided. A requirement is derived to verify and validate simulant performance versus lunar regolith from NASA s objectives for lunar simulants. This requirement leads to a specification that comparative measurements be taken the same way on the regolith and the simulant. In turn, this leads to a set of nine criteria with which to evaluate comparative measurements. Many of the potential measurements of interest are not defensible under these criteria. For example, many geotechnical properties of interest were not explicitly measured during Apollo and they can only be measured in situ on the Moon. A 2005 workshop identified 32 properties of major interest to users. Virtually all of the properties are tightly constrained, though not predictable, if just four parameters are controlled. Three parameters (composition, size, and shape) are recognized as being definable at the particle level. The fourth parameter (density) is a bulk property. In recent work, a fifth parameter (spectroscopy) has been identified, which will need to be added to future releases of the FoM.

  10. Programming and Tuning a Quantum Annealing Device to Solve Real World Problems

    NASA Astrophysics Data System (ADS)

    Perdomo-Ortiz, Alejandro; O'Gorman, Bryan; Fluegemann, Joseph; Smelyanskiy, Vadim

    2015-03-01

    Solving real-world applications with quantum algorithms requires overcoming several challenges, ranging from translating the computational problem at hand to the quantum-machine language to tuning parameters of the quantum algorithm that have a significant impact on the performance of the device. In this talk, we discuss these challenges, strategies developed to enhance performance, and also a more efficient implementation of several applications. Although we will focus on applications of interest to NASA's Quantum Artificial Intelligence Laboratory, the methods and concepts presented here apply to a broader family of hard discrete optimization problems, including those that occur in many machine-learning algorithms.

  11. Diffusion of cesium and iodine in compressed IG-110 graphite compacts

    NASA Astrophysics Data System (ADS)

    Carter, L. M.; Brockman, J. D.; Robertson, J. D.; Loyalka, S. K.

    2016-08-01

    Nuclear graphite grade IG-110 is currently used in the High Temperature Engineering Test Reactor (HTTR) in Japan for certain permanent and replaceable core components, and is a material of interest in general. Therefore, transport parameters for fission products in this material are needed. Measurement of diffusion through pressed compacts of IG-110 graphite is experimentally attractive because they are easy to prepare with homogeneous distributions of fission product surrogates. In this work, we measured diffusion coefficients for Cs and I in pressed compacts made from IG-110 powder in the 1079-1290 K temperature range, and compared them to those obtained in as-received IG-110.

  12. Signatures of a hidden cosmic microwave background.

    PubMed

    Jaeckel, Joerg; Redondo, Javier; Ringwald, Andreas

    2008-09-26

    If there is a light Abelian gauge boson gamma' in the hidden sector its kinetic mixing with the photon can produce a hidden cosmic microwave background (HCMB). For meV masses, resonant oscillations gamma<-->gamma' happen after big bang nucleosynthesis (BBN) but before CMB decoupling, increasing the effective number of neutrinos Nnu(eff) and the baryon to photon ratio, and distorting the CMB blackbody spectrum. The agreement between BBN and CMB data provides new constraints. However, including Lyman-alpha data, Nnu(eff) > 3 is preferred. It is tempting to attribute this effect to the HCMB. The interesting parameter range will be tested in upcoming laboratory experiments.

  13. Antiferromagnetic resonance excited by oscillating electric currents

    NASA Astrophysics Data System (ADS)

    Sluka, Volker

    2017-12-01

    In antiferromagnetic materials the order parameter exhibits resonant modes at frequencies that can be in the terahertz range, making them interesting components for spintronic devices. Here, it is shown that antiferromagnetic resonance can be excited using the inverse spin-Hall effect in a system consisting of an antiferromagnetic insulator coupled to a normal-metal waveguide. The time-dependent interplay between spin torque, ac spin accumulation, and magnetic degrees of freedom is studied. It is found that the dynamics of the antiferromagnet affects the frequency-dependent conductivity of the normal metal. Further, a comparison is made between spin-current-induced and Oersted-field-induced excitation under the condition of constant power injection.

  14. Mathematical modelling of thin films growth and calculation of coefficients reflection, transmission and absorption waves

    NASA Astrophysics Data System (ADS)

    Istratov, A. V.; Gerke, M. N.

    2018-01-01

    Progress in nano- and microsystem technology is directly related to the development of thin-film technologies. At the present time, thin metal films can serve as the basis for the creation of new instruments for nanoelectronics. One of the important parameters of thin films affecting the characteristics of devices is their optical properties. That is why the island structures, whose optical properties, can change in a wide range depending on their morphology, are of increasing interest. However, despite the large amount of research conducted by scientists from different countries, many questions about the optimal production and use of thin films remain unresolved.

  15. Dissipative nonlinear waves in a gravitating quantum fluid

    NASA Astrophysics Data System (ADS)

    Sahu, Biswajit; Sinha, Anjana; Roychoudhury, Rajkumar

    2018-02-01

    Nonlinear wave propagation is studied in a dissipative, self-gravitating Bose-Einstein condensate, starting from the Gross-Pitaevskii equation. In the absence of an exact analytical result, approximate methods like the linear analysis and perturbative approach are applied. The linear dispersion relation puts a restriction on the permissible range of the dissipation parameter. The waves get damped due to dissipation. The small amplitude analysis using reductive perturbation technique is found to yield a modified form of KdV equation, which is solved both analytically as well as numerically. Interestingly, the analytical and numerical plots match excellently with each other, in the realm of weak dissipation.

  16. Bioinformatic scaling of allosteric interactions in biomedical isozymes

    NASA Astrophysics Data System (ADS)

    Phillips, J. C.

    2016-09-01

    Allosteric (long-range) interactions can be surprisingly strong in proteins of biomedical interest. Here we use bioinformatic scaling to connect prior results on nonsteroidal anti-inflammatory drugs to promising new drugs that inhibit cancer cell metabolism. Many parallel features are apparent, which explain how even one amino acid mutation, remote from active sites, can alter medical results. The enzyme twins involved are cyclooxygenase (aspirin) and isocitrate dehydrogenase (IDH). The IDH results are accurate to 1% and are overdetermined by adjusting a single bioinformatic scaling parameter. It appears that the final stage in optimizing protein functionality may involve leveling of the hydrophobic limits of the arms of conformational hydrophilic hinges.

  17. Microwave life detector for buried victims using neutrodyning loop based system

    NASA Astrophysics Data System (ADS)

    Tahar J., Bel Hadj

    2009-07-01

    This paper describes a new design of an electromagnetic life detector for the detection of buried victims. The principle of the microwave life sensor is based on the detection of the modulated part of a scattered wave which is generated by the breathing activity of the victim. Those movements generate a spectral component located in the low frequency range, which for most of the cases, is located in a spectrum extending from 0.18 Hz to 0.34 Hz. The detection process requires high sensitivity with respect to breathing movements and, simultaneously, a relative insensitivity for other non-modulated or modulated parasitic signals. Developed microwave system, generating a frequency adjustable between 500 MHz and 1 GHz, is based on a neutrodyning loop required to cancel any non-modulated background and reflected signals in order to get better receiver sensitivity without introducing supplementary distortions on the received signal. Life signal is considered practically periodic that facilitates the extraction of this spectral component using several processing techniques, such as adaptive filtering and correlation permitting to ameliorate the detection range to be more than 15 m in low-loss medium. Detection range is a fundamental parameter for a microwave life detector. A range around 1 m doesn't have a large interest for this application. To attain a range more than 15 m, while guaranteeing professional performances, the technology has to optimize the system parameters as well as the involved signal processing for the purpose of overcoming the presence of obstacles, attenuation, and noise perturbation. This constitutes the main contribution of the present work. Experimental measurements have confirmed the potentiality of this microwave technique for life detector with best space covering detection.

  18. Coevolution of Cooperation and Partner Rewiring Range in Spatial Social Networks

    NASA Astrophysics Data System (ADS)

    Khoo, Tommy; Fu, Feng; Pauls, Scott

    2016-11-01

    In recent years, there has been growing interest in the study of coevolutionary games on networks. Despite much progress, little attention has been paid to spatially embedded networks, where the underlying geographic distance, rather than the graph distance, is an important and relevant aspect of the partner rewiring process. It thus remains largely unclear how individual partner rewiring range preference, local vs. global, emerges and affects cooperation. Here we explicitly address this issue using a coevolutionary model of cooperation and partner rewiring range preference in spatially embedded social networks. In contrast to local rewiring, global rewiring has no distance restriction but incurs a one-time cost upon establishing any long range link. We find that under a wide range of model parameters, global partner switching preference can coevolve with cooperation. Moreover, the resulting partner network is highly degree-heterogeneous with small average shortest path length while maintaining high clustering, thereby possessing small-world properties. We also discover an optimum availability of reputation information for the emergence of global cooperators, who form distant partnerships at a cost to themselves. From the coevolutionary perspective, our work may help explain the ubiquity of small-world topologies arising alongside cooperation in the real world.

  19. Multi-tiered S-SOA, Parameter-Driven New Islamic Syariah Products of Holistic Islamic Banking System (HiCORE): Virtual Banking Environment

    NASA Astrophysics Data System (ADS)

    Halimah, B. Z.; Azlina, A.; Sembok, T. M.; Sufian, I.; Sharul Azman, M. N.; Azuraliza, A. B.; Zulaiha, A. O.; Nazlia, O.; Salwani, A.; Sanep, A.; Hailani, M. T.; Zaher, M. Z.; Azizah, J.; Nor Faezah, M. Y.; Choo, W. O.; Abdullah, Chew; Sopian, B.

    The Holistic Islamic Banking System (HiCORE), a banking system suitable for virtual banking environment, created based on universityindustry collaboration initiative between Universiti Kebangsaan Malaysia (UKM) and Fuziq Software Sdn Bhd. HiCORE was modeled on a multitiered Simple - Services Oriented Architecture (S-SOA), using the parameterbased semantic approach. HiCORE's existence is timely as the financial world is looking for a new approach to creating banking and financial products that are interest free or based on the Islamic Syariah principles and jurisprudence. An interest free banking system has currently caught the interest of bankers and financiers all over the world. HiCORE's Parameter-based module houses the Customer-information file (CIF), Deposit and Financing components. The Parameter based module represents the third tier of the multi-tiered Simple SOA approach. This paper highlights the multi-tiered parameter- driven approach to the creation of new Islamiic products based on the 'dalil' (Quran), 'syarat' (rules) and 'rukun' (procedures) as required by the syariah principles and jurisprudence reflected by the semantic ontology embedded in the parameter module of the system.

  20. Accuracy in parameter estimation for targeted effects in structural equation modeling: sample size planning for narrow confidence intervals.

    PubMed

    Lai, Keke; Kelley, Ken

    2011-06-01

    In addition to evaluating a structural equation model (SEM) as a whole, often the model parameters are of interest and confidence intervals for those parameters are formed. Given a model with a good overall fit, it is entirely possible for the targeted effects of interest to have very wide confidence intervals, thus giving little information about the magnitude of the population targeted effects. With the goal of obtaining sufficiently narrow confidence intervals for the model parameters of interest, sample size planning methods for SEM are developed from the accuracy in parameter estimation approach. One method plans for the sample size so that the expected confidence interval width is sufficiently narrow. An extended procedure ensures that the obtained confidence interval will be no wider than desired, with some specified degree of assurance. A Monte Carlo simulation study was conducted that verified the effectiveness of the procedures in realistic situations. The methods developed have been implemented in the MBESS package in R so that they can be easily applied by researchers. © 2011 American Psychological Association

  1. Bayesian Analysis of Non-Gaussian Long-Range Dependent Processes

    NASA Astrophysics Data System (ADS)

    Graves, T.; Franzke, C.; Gramacy, R. B.; Watkins, N. W.

    2012-12-01

    Recent studies have strongly suggested that surface temperatures exhibit long-range dependence (LRD). The presence of LRD would hamper the identification of deterministic trends and the quantification of their significance. It is well established that LRD processes exhibit stochastic trends over rather long periods of time. Thus, accurate methods for discriminating between physical processes that possess long memory and those that do not are an important adjunct to climate modeling. We have used Markov Chain Monte Carlo algorithms to perform a Bayesian analysis of Auto-Regressive Fractionally-Integrated Moving-Average (ARFIMA) processes, which are capable of modeling LRD. Our principal aim is to obtain inference about the long memory parameter, d,with secondary interest in the scale and location parameters. We have developed a reversible-jump method enabling us to integrate over different model forms for the short memory component. We initially assume Gaussianity, and have tested the method on both synthetic and physical time series such as the Central England Temperature. Many physical processes, for example the Faraday time series from Antarctica, are highly non-Gaussian. We have therefore extended this work by weakening the Gaussianity assumption. Specifically, we assume a symmetric α -stable distribution for the innovations. Such processes provide good, flexible, initial models for non-Gaussian processes with long memory. We will present a study of the dependence of the posterior variance σ d of the memory parameter d on the length of the time series considered. This will be compared with equivalent error diagnostics for other measures of d.

  2. Chemical freezeout parameters within generic nonextensive statistics

    NASA Astrophysics Data System (ADS)

    Tawfik, Abdel; Yassin, Hayam; Abo Elyazeed, Eman R.

    2018-06-01

    The particle production in relativistic heavy-ion collisions seems to be created in a dynamically disordered system which can be best described by an extended exponential entropy. In distinguishing between the applicability of this and Boltzmann-Gibbs (BG) in generating various particle-ratios, generic (non)extensive statistics is introduced to the hadron resonance gas model. Accordingly, the degree of (non)extensivity is determined by the possible modifications in the phase space. Both BG extensivity and Tsallis nonextensivity are included as very special cases defined by specific values of the equivalence classes (c, d). We found that the particle ratios at energies ranging between 3.8 and 2760 GeV are best reproduced by nonextensive statistics, where c and d range between ˜ 0.9 and ˜ 1 . The present work aims at illustrating that the proposed approach is well capable to manifest the statistical nature of the system on interest. We don't aim at highlighting deeper physical insights. In other words, while the resulting nonextensivity is neither BG nor Tsallis, the freezeout parameters are found very compatible with BG and accordingly with the well-known freezeout phase-diagram, which is in an excellent agreement with recent lattice calculations. We conclude that the particle production is nonextensive but should not necessarily be accompanied by a radical change in the intensive or extensive thermodynamic quantities, such as internal energy and temperature. Only, the two critical exponents defining the equivalence classes (c, d) are the physical parameters characterizing the (non)extensivity.

  3. A new method to estimate average hourly global solar radiation on the horizontal surface

    NASA Astrophysics Data System (ADS)

    Pandey, Pramod K.; Soupir, Michelle L.

    2012-10-01

    A new model, Global Solar Radiation on Horizontal Surface (GSRHS), was developed to estimate the average hourly global solar radiation on the horizontal surfaces (Gh). The GSRHS model uses the transmission function (Tf,ij), which was developed to control hourly global solar radiation, for predicting solar radiation. The inputs of the model were: hour of day, day (Julian) of year, optimized parameter values, solar constant (H0), latitude, and longitude of the location of interest. The parameter values used in the model were optimized at a location (Albuquerque, NM), and these values were applied into the model for predicting average hourly global solar radiations at four different locations (Austin, TX; El Paso, TX; Desert Rock, NV; Seattle, WA) of the United States. The model performance was assessed using correlation coefficient (r), Mean Absolute Bias Error (MABE), Root Mean Square Error (RMSE), and coefficient of determinations (R2). The sensitivities of parameter to prediction were estimated. Results show that the model performed very well. The correlation coefficients (r) range from 0.96 to 0.99, while coefficients of determination (R2) range from 0.92 to 0.98. For daily and monthly prediction, error percentages (i.e. MABE and RMSE) were less than 20%. The approach we proposed here can be potentially useful for predicting average hourly global solar radiation on the horizontal surface for different locations, with the use of readily available data (i.e. latitude and longitude of the location) as inputs.

  4. Performance evaluation of the new fully automated urine particle analyser UF-5000 compared to the reference method of the Fuchs-Rosenthal chamber.

    PubMed

    Previtali, Giulia; Ravasio, Rudi; Seghezzi, Michela; Buoro, Sabrina; Alessio, Maria Grazia

    2017-09-01

    UF-5000 is the new fully automated urine particle analyser. We validated its performance. 736 urines were analysed and results were compared by two pathologists on uncentrifuged samples, using Fuchs-Rosenthal chamber. AUC of ROC curve ranged between 0.86 and 0.99. Sensitivity was >0.90 for all the elements and similar for RBC and yeasts. Specificity ranged between 0.74 and 0.89 for total cast, epithelial/non-squamous/renal-tubular cells and RBC. For all the other parameters specificity was >0.90. Comparison with Fuchs-Rosenthal chamber was very good for all the parameters; r ranged between 0.52 and 0.99 except for pathological cast because of the lack of the pathological samples in medium and higher ranges. Linearity performance (R 2 ) was 1.00, 1.00 and 0.99 respectively for RBC, WBC and epithelial cells (EC). No carry-over was observed. The within-run imprecision was 25.42%,13.81%,1.36% for RBC; 37.50%,10.16%,1.41% for WBC and 35.25%, 17.85%,6.30% for EC at low, near the cut off level and high concentrations, respectively. The between-run imprecision was 6.90%,1.60% for RBC, 4.10%,1.90% for WBC and 7.60%,7.30% for EC, using low and high positive quality controls, respectively. UF-5000 is an analyser of great interest to detect urine particle related to pathological process of kidney and urinary tract. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. A Bayesian state-space formulation of dynamic occupancy models

    USGS Publications Warehouse

    Royle, J. Andrew; Kery, M.

    2007-01-01

    Species occurrence and its dynamic components, extinction and colonization probabilities, are focal quantities in biogeography and metapopulation biology, and for species conservation assessments. It has been increasingly appreciated that these parameters must be estimated separately from detection probability to avoid the biases induced by nondetection error. Hence, there is now considerable theoretical and practical interest in dynamic occupancy models that contain explicit representations of metapopulation dynamics such as extinction, colonization, and turnover as well as growth rates. We describe a hierarchical parameterization of these models that is analogous to the state-space formulation of models in time series, where the model is represented by two components, one for the partially observable occupancy process and another for the observations conditional on that process. This parameterization naturally allows estimation of all parameters of the conventional approach to occupancy models, but in addition, yields great flexibility and extensibility, e.g., to modeling heterogeneity or latent structure in model parameters. We also highlight the important distinction between population and finite sample inference; the latter yields much more precise estimates for the particular sample at hand. Finite sample estimates can easily be obtained using the state-space representation of the model but are difficult to obtain under the conventional approach of likelihood-based estimation. We use R and Win BUGS to apply the model to two examples. In a standard analysis for the European Crossbill in a large Swiss monitoring program, we fit a model with year-specific parameters. Estimates of the dynamic parameters varied greatly among years, highlighting the irruptive population dynamics of that species. In the second example, we analyze route occupancy of Cerulean Warblers in the North American Breeding Bird Survey (BBS) using a model allowing for site-specific heterogeneity in model parameters. The results indicate relatively low turnover and a stable distribution of Cerulean Warblers which is in contrast to analyses of counts of individuals from the same survey that indicate important declines. This discrepancy illustrates the inertia in occupancy relative to actual abundance. Furthermore, the model reveals a declining patch survival probability, and increasing turnover, toward the edge of the range of the species, which is consistent with metapopulation perspectives on the genesis of range edges. Given detection/non-detection data, dynamic occupancy models as described here have considerable potential for the study of distributions and range dynamics.

  6. Validation of the i-STAT and HemoCue systems for the analysis of blood parameters in the bar-headed goose, Anser indicus

    PubMed Central

    Harter, T. S.; Reichert, M.; Brauner, C. J.; Milsom, W. K.

    2015-01-01

    Every year, bar-headed geese (Anser indicus) perform some of the most remarkable trans-Himalayan migrations, and researchers are increasingly interested in understanding the physiology underlying their high-altitude flight performance. A major challenge is generating reliable measurements of blood parameters on wild birds in the field, where established analytical techniques are often not available. Therefore, we validated two commonly used portable clinical analysers (PCAs), the i-STAT and the HemoCue systems, for the analysis of blood parameters in bar-headed geese. The pH, partial pressures of O2 and CO2 (PO2 and PCO2), haemoglobin O2 saturation (sO2), haematocrit (Hct) and haemoglobin concentration [Hb] were simultaneously measured with the two PCA systems (i-STAT for all parameters; HemoCue for [Hb]) and with conventional laboratory techniques over a physiological range of PO2, PCO2 and Hct. Our results indicate that the i-STAT system can generate reliable values on bar-headed goose whole blood pH, PO2, PCO2 and Hct, but we recommend correcting the obtained values using the linear equations determined here for higher accuracy. The i-STAT is probably not able to produce meaningful measurements of sO2 and [Hb] over a range of physiologically relevant environmental conditions. However, we can recommend the use of the HemoCue to measure [Hb] in the bar-headed goose, if results are corrected. We emphasize that the equations that we provide to correct PCA results are applicable only to bar-headed goose whole blood under the conditions that we tested. We encourage researchers to validate i-STAT or HemoCue results thoroughly for their specific study conditions and species in order to yield accurate results. PMID:27293706

  7. Modeling and characteristic of the SMT Board Plug connector in high speed optical communication system

    NASA Astrophysics Data System (ADS)

    Wu, Haoran; Dong, Zhenzhen; Wang, Tanglin; Zhao, Heng; Feng, Junbo; Cui, Naidi; Teng, Jie; Guo, Jin

    2015-04-01

    Modeling and characteristic of the SMT Board Plug connector, which is used to connect micro optical transceiver to the main board, are proposed and analyzed in this paper. When the high speed signal transfers from the PCB of transceiver to main board through SMT Board Plug connector, the structure and material discontinuity of the connector causes insertion losses and impedance mismatches. This makes the performance of high speed digital system exacerbated. So it is essential to analyze the signal transfer characteristics of the connector and find out what factors affected the signal quality at the design stage of the digital system. To solve this problem, Ansoft's High Frequency Structure Simulator (HFSS), based on the finite element method, was employed to build accurate 3D models, analyze the effects of various structure parameters, and obtain the full-wave characteristics of the SMT Board Plug connectors in this paper. Then an equivalent circuit model was developed. The circuit parameters were extracted precisely in the frequency range of interests by using the curve fitting method in ADS software, and the result was in good agreement with HFSS simulations up to 8GHz with different structure parameters. At last, the measurement results of S-parameter and eye diagram were given and the S-parameters showed good coincidence between the measurement and HFSS simulation up to 4GHz.

  8. Estimation of bipolar jets from accretion discs around Kerr black holes

    NASA Astrophysics Data System (ADS)

    Kumar, Rajiv; Chattopadhyay, Indranil

    2017-08-01

    We analyse flows around a rotating black hole and obtain self-consistent accretion-ejection solutions in full general relativistic prescription. Entire energy-angular momentum parameter space is investigated in the advective regime to obtain shocked and shock-free accretion solutions. Jet equations of motion are solved along the von Zeipel surfaces computed from the post-shock disc, simultaneously with the equations of accretion disc along the equatorial plane. For a given spin parameter, the mass outflow rate increases as the shock moves closer to the black hole, but eventually decreases, maximizing at some intermediate value of shock location. Interestingly, we obtain all types of possible jet solutions, for example, steady shock solution with multiple critical points, bound solution with two critical points and smooth solution with single critical point. Multiple critical points may exist in jet solution for spin parameter as ≥ 0.5. The jet terminal speed generally increases if the accretion shock forms closer to the horizon and is higher for corotating black hole than the counter-rotating and the non-rotating one. Quantitatively speaking, shocks in jet may form for spin parameter as > 0.6 and jet shocks range between 6rg and 130rg above the equatorial plane, while the jet terminal speed vj∞ > 0.35 c if Bernoulli parameter E≥1.01 for as > 0.99.

  9. Merging physical parameters and laboratory subjective ratings for the soundscape assessment of urban squares.

    PubMed

    Brambilla, Giovanni; Maffei, Luigi; Di Gabriele, Maria; Gallo, Veronica

    2013-07-01

    An experimental study was carried out in 20 squares in the center of Rome, covering a wide range of different uses, sonic environments, geometry, and architectural styles. Soundwalks along the perimeter of each square were performed during daylight and weekdays taking binaural and video recordings, as well as spot measurements of illuminance. The cluster analysis performed on the physical parameters, not only acoustic, provided two clusters that are in satisfactory agreement with the "a priori" classification. Applying the principal component analysis (PCA) to five physical parameters, two main components were obtained which might be associated to two environmental features, namely, "chaotic/calm" and "open/enclosed." On the basis of these two features, six squares were selected for the laboratory audio-video tests where 32 subjects took part filling in a questionnaire. The PCA performed on the subjective ratings on the sonic environment showed two main components which might be associated to two emotional meanings, namely, "calmness" and "vibrancy." The linear regression modeling between five objective parameters and the mean value of subjective ratings on chaotic/calm and enclosed/open attributes showed a good correlation. Notwithstanding these interesting results being limited to the specific data set, it is worth pointing out that the complexity of the soundscape quality assessment can be more comprehensively examined merging the field measurements of physical parameters with the subjective ratings provided by field and/or laboratory tests.

  10. An automatic segmentation method of a parameter-adaptive PCNN for medical images.

    PubMed

    Lian, Jing; Shi, Bin; Li, Mingcong; Nan, Ziwei; Ma, Yide

    2017-09-01

    Since pre-processing and initial segmentation steps in medical images directly affect the final segmentation results of the regions of interesting, an automatic segmentation method of a parameter-adaptive pulse-coupled neural network is proposed to integrate the above-mentioned two segmentation steps into one. This method has a low computational complexity for different kinds of medical images and has a high segmentation precision. The method comprises four steps. Firstly, an optimal histogram threshold is used to determine the parameter [Formula: see text] for different kinds of images. Secondly, we acquire the parameter [Formula: see text] according to a simplified pulse-coupled neural network (SPCNN). Thirdly, we redefine the parameter V of the SPCNN model by sub-intensity distribution range of firing pixels. Fourthly, we add an offset [Formula: see text] to improve initial segmentation precision. Compared with the state-of-the-art algorithms, the new method achieves a comparable performance by the experimental results from ultrasound images of the gallbladder and gallstones, magnetic resonance images of the left ventricle, and mammogram images of the left and the right breast, presenting the overall metric UM of 0.9845, CM of 0.8142, TM of 0.0726. The algorithm has a great potential to achieve the pre-processing and initial segmentation steps in various medical images. This is a premise for assisting physicians to detect and diagnose clinical cases.

  11. Radio sounding of the solar corona during 1995 solar conjunction of the Ulysses spacecraft

    NASA Technical Reports Server (NTRS)

    Bird, M. K.; Paetzold, M.; Karl, J.; Edenhofer, P.; Asmar, S. W.

    1995-01-01

    The Ulysses spacecraft will pass through superior solar conjunction on March 5 1995, a few days before its perihelion and passage through the ecliptic plane. Dual-frequency S/X-band ranging and Doppler observations will be conducted in support of the Ulysses Solar Corona Experiment (SCE) during a three-week interval centered on the conjunction. The occultation geometry is unique in the annals of interplanetary exploration. As viewed from Earth, the spacecraft will appear to cut diagonally through the southwest quadrant of the solar corona from the South Pole to the equator. The minimum proximate distance to the Sun of the radio ray path will be 21.6 solar radius. The entire latitude scan from pole to equator occurs for a limited range of solar offset distances (is less than 30 solar radius thus facilitating the separation of latitudinal from radial variations in the coronal density and associated parameters of interest.

  12. Inland and coastal waters

    NASA Astrophysics Data System (ADS)

    Mouw, Colleen; Greb, Steven

    2012-09-01

    Workshop for Remote Sensing of Coastal and Inland Waters;Madison, Wisconsin, 20-22 June 2012 Coastal and inland water bodies, which have great value for recreation, food supply, commerce, transportation, and human health, have been experiencing external pressure from direct human activities and climate change. Given their societal and economic value, understanding issues of water quality, water quantity, and the impact of environmental change on the ecological and biogeochemical functioning of these water bodies is of interest to a broad range of communities. Remote sensing offers one of the most spatially and temporally comprehensive tools for observing these waters. While there has been some success with remotely observing these water bodies, many challenges still remain, including algorithm performance, atmospheric correction, the relationships between optical properties and biogeochemical parameters, sufficient spatial and spectral resolution, and a lack of uncertainty estimates over the wide range of environmental conditions encountered across these coastal and inland water bodies.

  13. Optimal design of sound absorbing systems with microperforated panels

    NASA Astrophysics Data System (ADS)

    Kim, Nicholas Nakjoo

    As the development of technology makes economic prosperity and life more convenient, people now desire a higher quality of life. This quality of life is based not only on the convenience in their life but also on clean and eco-friendly environments. To meet that requirement, much research is being performed in many areas of eco-friendly technology, such as renewable energy, biodegradable content, and batteries for electronic vehicles. This tendency is also obvious in the acoustics area, where there are continuing attempts to replace fiber-glass sound absorbers with fiber-free materials. The combination of microperfoated panels (MPP) (one of the fiber-free sound absorbing materials), usually in the form of a thin panel with small holes, and an air backing may be one of the preferred solutions. These panels can be designed in many ways, and usually feature many small (sub-millimeter) holes and typically surface porosities on the order of 1 percent. The detailed acoustical properties of MPPs depend on their hole shape, the hole diameter, the thickness of the panel, the overall porosity of the perforated film, the film's mass per unit area, and the depth of the backing air cavity. Together, these parameters control the absorption peak location and the magnitude of the absorption coefficient (and the magnitude of the transmission loss in barrier applications). By an appropriate choice of these parameters good absorption performance can be achieved in a frequency range one or two octaves wide. That kind of solution may be adequate when it is necessary to control sound only in a specified frequency range (in the speech interference range, for example). However, in order to provide appropriate noise control solutions over a broader range of frequencies, it is necessary to design systems featuring multiple-layers of MPPs, thus creating what amounts to a multi-degree-of-freedom system and so expanding the range over which good absorption can be obtained. In this research, three different situations were considered: one was studying the combination of microperforated panels with tapered holes and a specific depth of air backing space with a view to finding the trade-off between hole angle and surface porosity. Secondly, it was of interest to study the use of multiple-layer MPPs as functional absorbers. Finally, there is a study of the optimization of a multi-layer cylindrical duct liner that gives maximum axial attenuation. Note that "Functional Absorber" is the name given to a system that can be hung, in an industrial space, for example, to provide acoustic absorption. The duct applications of interest would be in HVAC systems, whether in buildings, automotive systems or personal ventilators. In both applications, the focus was on obtaining the best possible performance in the full speech interference range, which spans the range from 500 Hz to 4000 kHz. In each case, a transfer matrix method has been developed to calculate the transmission loss and absorption coefficients provided by the systems. Note finally that the design of an N multiple-layer MPP system depends on 5N-1 parameters, and so a general optimization becomes difficult in realistic cases when as many as ten layers might be used. Thus, the use of a genetic algorithm to optimize the system parameters has been adopted, since an algorithm of that sort can efficiently identify good solutions from a very large design space. The results, as presented in this thesis, show that it is possible to identify the best combination of MPP properties that improve the desired acoustic performance, whether absorption or transmission loss, in a prescribed frequency range.

  14. Modeling clear-sky solar radiation across a range of elevations in Hawai‘i: Comparing the use of input parameters at different temporal resolutions

    NASA Astrophysics Data System (ADS)

    Longman, Ryan J.; Giambelluca, Thomas W.; Frazier, Abby G.

    2012-01-01

    Estimates of clear sky global solar irradiance using the parametric model SPCTRAL2 were tested against clear sky radiation observations at four sites in Hawai`i using daily, mean monthly, and 1 year mean model parameter settings. Atmospheric parameters in SPCTRAL2 and similar models are usually set at site-specific values and are not varied to represent the effects of fluctuating humidity, aerosol amount and type, or ozone concentration, because time-dependent atmospheric parameter estimates are not available at most sites of interest. In this study, we sought to determine the added value of using time dependent as opposed to fixed model input parameter settings. At the AERONET site, Mauna Loa Observatory (MLO) on the island of Hawai`i, where daily measurements of atmospheric optical properties and hourly solar radiation observations are available, use of daily rather than 1 year mean aerosol parameter values reduced mean bias error (MBE) from 18 to 10 W m-2 and root mean square error from 25 to 17 W m-2. At three stations in the HaleNet climate network, located at elevations of 960, 1640, and 2590 m on the island of Maui, where aerosol-related parameter settings were interpolated from observed values for AERONET sites at MLO (3397 m) and Lāna`i (20 m), and precipitable water was estimated using radiosonde-derived humidity profiles from nearby Hilo, the model performed best when using constant 1 year mean parameter values. At HaleNet Station 152, for example, MBE was 18, 10, and 8 W m-2 for daily, monthly, and 1 year mean parameters, respectively.

  15. Bayesian inference to identify parameters in viscoelasticity

    NASA Astrophysics Data System (ADS)

    Rappel, Hussein; Beex, Lars A. A.; Bordas, Stéphane P. A.

    2017-08-01

    This contribution discusses Bayesian inference (BI) as an approach to identify parameters in viscoelasticity. The aims are: (i) to show that the prior has a substantial influence for viscoelasticity, (ii) to show that this influence decreases for an increasing number of measurements and (iii) to show how different types of experiments influence the identified parameters and their uncertainties. The standard linear solid model is the material description of interest and a relaxation test, a constant strain-rate test and a creep test are the tensile experiments focused on. The experimental data are artificially created, allowing us to make a one-to-one comparison between the input parameters and the identified parameter values. Besides dealing with the aforementioned issues, we believe that this contribution forms a comprehensible start for those interested in applying BI in viscoelasticity.

  16. Modelling of temperature and perfusion during scalp cooling

    NASA Astrophysics Data System (ADS)

    Janssen, F. E. M.; Van Leeuwen, G. M. J.; Van Steenhoven, A. A.

    2005-09-01

    Hair loss is a feared side effect of chemotherapy treatment. It may be prevented by cooling the scalp during administration of cytostatics. The supposed mechanism is that by cooling the scalp, both temperature and perfusion are diminished, affecting drug supply and drug uptake in the hair follicle. However, the effect of scalp cooling varies strongly. To gain more insight into the effect of cooling, a computer model has been developed that describes heat transfer in the human head during scalp cooling. Of main interest in this study are the mutual influences of scalp temperature and perfusion during cooling. Results of the standard head model show that the temperature of the scalp skin is reduced from 34.4 °C to 18.3 °C, reducing tissue blood flow to 25%. Based upon variations in both thermal properties and head anatomies found in the literature, a parameter study was performed. The results of this parameter study show that the most important parameters affecting both temperature and perfusion are the perfusion coefficient Q10 and the thermal resistances of both the fat and the hair layer. The variations in the parameter study led to skin temperature ranging from 10.1 °C to 21.8 °C, which in turn reduced relative perfusion to 13% and 33%, respectively.

  17. Tracking Multiple Topics for Finding Interesting Articles

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pon, R K; Cardenas, A F; Buttler, D J

    We introduce multiple topic tracking (MTT) for iScore to better recommend news articles for users with multiple interests and to address changes in user interests over time. As an extension of the basic Rocchio algorithm, traditional topic detection and tracking, and single-pass clustering, MTT maintains multiple interest profiles to identify interesting articles for a specific user given user-feedback. Focusing on only interesting topics enables iScore to discard useless profiles to address changes in user interests and to achieve a balance between resource consumption and classification accuracy. iScore is able to achieve higher quality results than traditional methods such as themore » Rocchio algorithm. We identify several operating parameters that work well for MTT. Using the same parameters, we show that MTT alone yields high quality results for recommending interesting articles from several corpora. The inclusion of MTT improves iScore's performance by 25% in recommending news articles from the Yahoo! News RSS feeds and the TREC11 adaptive filter article collection. And through a small user study, we show that iScore can still perform well when only provided with little user feedback.« less

  18. Influence of Time-Pickoff Circuit Parameters on LiDAR Range Precision

    PubMed Central

    Wang, Hongming; Yang, Bingwei; Huyan, Jiayue; Xu, Lijun

    2017-01-01

    A pulsed time-of-flight (TOF) measurement-based Light Detection and Ranging (LiDAR) system is more effective for medium-long range distances. As a key ranging unit, a time-pickoff circuit based on automatic gain control (AGC) and constant fraction discriminator (CFD) is designed to reduce the walk error and the timing jitter for obtaining the accurate time interval. Compared with Cramer–Rao lower bound (CRLB) and the estimation of the timing jitter, four parameters-based Monte Carlo simulations are established to show how the range precision is influenced by the parameters, including pulse amplitude, pulse width, attenuation fraction and delay time of the CFD. Experiments were carried out to verify the relationship between the range precision and three of the parameters, exclusing pulse width. It can be concluded that two parameters of the ranging circuit (attenuation fraction and delay time) were selected according to the ranging performance of the minimum pulse amplitude. The attenuation fraction should be selected in the range from 0.2 to 0.6 to achieve high range precision. The selection criterion of the time-pickoff circuit parameters is helpful for the ranging circuit design of TOF LiDAR system. PMID:29039772

  19. Response to ``Comment on `Adaptive Q-S (lag, anticipated, and complete) time-varying synchronization and parameters identification of uncertain delayed neural networks''' [Chaos 17, 038101 (2007)

    NASA Astrophysics Data System (ADS)

    Yu, Wenwu; Cao, Jinde

    2007-09-01

    Parameter identification of dynamical systems from time series has received increasing interest due to its wide applications in secure communication, pattern recognition, neural networks, and so on. Given the driving system, parameters can be estimated from the time series by using an adaptive control algorithm. Recently, it has been reported that for some stable systems, in which parameters are difficult to be identified [Li et al., Phys Lett. A 333, 269-270 (2004); Remark 5 in Yu and Cao, Physica A 375, 467-482 (2007); and Li et al., Chaos 17, 038101 (2007)], and in this paper, a brief discussion about whether parameters can be identified from time series is investigated. From some detailed analyses, the problem of why parameters of stable systems can be hardly estimated is discussed. Some interesting examples are drawn to verify the proposed analysis.

  20. Experimental study of combustion in hydrogen peroxide hybrid rockets

    NASA Astrophysics Data System (ADS)

    Wernimont, Eric John

    Combustion behavior in a hydrogen peroxide oxidized hybrid rocket motor is investigated with a series of experiments. Hybrid chemical rocket propulsion is presently of interest due to reduced system complexity compared to classical chemical propulsion systems. Reduced system complexity, by use of a storable oxidizer and a hybrid configuration, is expected to reduce propulsive costs. The fuel in this study is polyethylene which has the potential of continuous manufacture leading to further reduced system costs. The study investigated parameters of interest for nominal design of a full scale hydrogen peroxide oxidized hybrid rocket. Amongst these parameters is the influence of chamber pressure, mass flux, fuel molecular weight and fuel density on fuel regression rate. Effects of chamber pressure and aft combustion length on combustion efficiency and non-acoustic combustion oscillations are also examined. The fuel regression behavior is found to be strongly influenced by both chamber pressure and mass flux. Combustion efficiencies in the upper 90% range are attained by simple changes to the aft combustion chamber length as well as increased combustion pressure. Fuel burning surface is found to be influenced by the density of the polyethylene polymer as well as molecular weight. The combustion is observed to be exceptionally smooth (oscillations less than 5% zero-to-peak of mean) in all motors tested in this program. Tests using both a single port fuel gain and a novel radial flow hybrid are also performed.

  1. How to make thermodynamic perturbation theory to be suitable for low temperature?

    NASA Astrophysics Data System (ADS)

    Zhou, Shiqi

    2009-02-01

    Low temperature unsuitability is a problem plaguing thermodynamic perturbation theory (TPT) for years. Present investigation indicates that the low temperature predicament can be overcome by employing as reference system a nonhard sphere potential which incorporates one part of the attractive ingredient in a potential function of interest. In combination with a recently proposed TPT [S. Zhou, J. Chem. Phys. 125, 144518 (2006)] based on a λ expansion (λ being coupling parameter), the new perturbation strategy is employed to predict for several model potentials. It is shown that the new perturbation strategy can very accurately predict various thermodynamic properties even if the potential range is extremely short and hence the temperature of interest is very low and current theoretical formalisms seriously deteriorate or critically fail to predict even the existence of the critical point. Extensive comparison with existing liquid state theories and available computer simulation data discloses a superiority of the present TPT to two Ornstein-Zernike-type integral equation theories, i.e., hierarchical reference theory and self-consistent Ornstein-Zernike approximation.

  2. How to make thermodynamic perturbation theory to be suitable for low temperature?

    PubMed

    Zhou, Shiqi

    2009-02-07

    Low temperature unsuitability is a problem plaguing thermodynamic perturbation theory (TPT) for years. Present investigation indicates that the low temperature predicament can be overcome by employing as reference system a nonhard sphere potential which incorporates one part of the attractive ingredient in a potential function of interest. In combination with a recently proposed TPT [S. Zhou, J. Chem. Phys. 125, 144518 (2006)] based on a lambda expansion (lambda being coupling parameter), the new perturbation strategy is employed to predict for several model potentials. It is shown that the new perturbation strategy can very accurately predict various thermodynamic properties even if the potential range is extremely short and hence the temperature of interest is very low and current theoretical formalisms seriously deteriorate or critically fail to predict even the existence of the critical point. Extensive comparison with existing liquid state theories and available computer simulation data discloses a superiority of the present TPT to two Ornstein-Zernike-type integral equation theories, i.e., hierarchical reference theory and self-consistent Ornstein-Zernike approximation.

  3. Giant current fluctuations in an overheated single-electron transistor

    NASA Astrophysics Data System (ADS)

    Laakso, M. A.; Heikkilä, T. T.; Nazarov, Yuli V.

    2010-11-01

    Interplay of cotunneling and single-electron tunneling in a thermally isolated single-electron transistor leads to peculiar overheating effects. In particular, there is an interesting crossover interval where the competition between cotunneling and single-electron tunneling changes to the dominance of the latter. In this interval, the current exhibits anomalous sensitivity to the effective electron temperature of the transistor island and its fluctuations. We present a detailed study of the current and temperature fluctuations at this interesting point. The methods implemented allow for a complete characterization of the distribution of the fluctuating quantities, well beyond the Gaussian approximation. We reveal and explore the parameter range where, for sufficiently small transistor islands, the current fluctuations become gigantic. In this regime, the optimal value of the current, its expectation value, and its standard deviation differ from each other by parametrically large factors. This situation is unique for transport in nanostructures and for electron transport in general. The origin of this spectacular effect is the exponential sensitivity of the current to the fluctuating effective temperature.

  4. Phenomenological study of exclusive binary light particle production from antiproton-proton annihilation at FAIR/PANDA

    NASA Astrophysics Data System (ADS)

    Ying, Wang

    2016-08-01

    Exclusive binary annihilation reactions induced by antiprotons of momentum from 1.5 to 15 GeV/c can be extensively investigated at FAIR/PANDA [1]. We are especially interested in the channel of charged pion pairs. Whereas this very probable channel constitutes the major background for other processes of interest in the PANDA experiment, it carries unique physical information on the quark content of proton, allowing to test different models (quark counting rules, statistical models,..). To study the binary reactions of light meson formation, we are developing an effective Lagrangian model based on Feynman diagrams which takes into account the virtuality of the exchanged particles. Regge factors [2] and form factors are introduced with parameters which may be adjusted on the existing data. We present preliminary results of our formalism for different reactions of light meson production leading to reliable predictions of cross sections, energy and angular dependencies in the PANDA kinematical range.

  5. Fusion of AIRSAR and TM Data for Parameter Classification and Estimation in Dense and Hilly Forests

    NASA Technical Reports Server (NTRS)

    Moghaddam, Mahta; Dungan, J. L.; Coughlan, J. C.

    2000-01-01

    The expanded remotely sensed data space consisting of coincident radar backscatter and optical reflectance data provides for a more complete description of the Earth surface. This is especially useful where many parameters are needed to describe a certain scene, such as in the presence of dense and complex-structured vegetation or where there is considerable underlying topography. The goal of this paper is to use a combination of radar and optical data to develop a methodology for parameter classification for dense and hilly forests, and further, class-specific parameter estimation. The area to be used in this study is the H. J. Andrews Forest in Oregon, one of the Long-Term Ecological Research (LTER) sites in the US. This area consists of various dense old-growth conifer stands, and contains significant topographic relief. The Andrews forest has been the subject of many ecological studies over several decades, resulting in an abundance of ground measurements. Recently, biomass and leaf-area index (LAI) values for approximately 30 reference stands have also become available which span a large range of those parameters. The remote sensing data types to be used are the C-, L-, and P-band polarimetric radar data from the JPL airborne SAR (AIRSAR), the C-band single-polarization data from the JPL topographic SAR (TOPSAR), and the Thematic Mapper (TM) data from Landsat, all acquired in late April 1998. The total number of useful independent data channels from the AIRSAR is 15 (three frequencies, each with three unique polarizations and amplitude and phase of the like-polarized correlation), from the TOPSAR is 2 (amplitude and phase of the interferometric correlation), and from the TM is 6 (the thermal band is not used). The range pixel spacing of the AIRSAR is 3.3m for C- and L-bands and 6.6m for P-band. The TOPSAR pixel spacing is 10m, and the TM pixel size is 30m. To achieve parameter classification, first a number of parameters are defined which are of interest to ecologists for forest process modeling. These parameters include total biomass, leaf biomass, LAI, and tree height. The remote sensing data from radar and TM are used to formulate a multivariate analysis problem given the ground measurements of the parameters. Each class of each parameter is defined by a probability density function (pdf), the spread of which defines the range of that class. High classification accuracy results from situations in which little overlap occurs between pdfs. Classification results provide the basis for the future work of class-specific parameter estimation using radar and optical data. This work was performed in part by the Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, and in part by the NASA Ames Research Center, Moffett Field, CA, both under contract from the National Aeronautics and Space Administration.

  6. SU-D-12A-06: A Comprehensive Parameter Analysis for Low Dose Cone-Beam CT Reconstruction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lu, W; Southern Medical University, Guangzhou; Yan, H

    Purpose: There is always a parameter in compressive sensing based iterative reconstruction (IR) methods low dose cone-beam CT (CBCT), which controls the weight of regularization relative to data fidelity. A clear understanding of the relationship between image quality and parameter values is important. The purpose of this study is to investigate this subject based on experimental data and a representative advanced IR algorithm using Tight-frame (TF) regularization. Methods: Three data sets of a Catphan phantom acquired at low, regular and high dose levels are used. For each tests, 90 projections covering a 200-degree scan range are used for reconstruction. Threemore » different regions-of-interest (ROIs) of different contrasts are used to calculate contrast-to-noise ratios (CNR) for contrast evaluation. A single point structure is used to measure modulation transfer function (MTF) for spatial-resolution evaluation. Finally, we analyze CNRs and MTFs to study the relationship between image quality and parameter selections. Results: It was found that: 1) there is no universal optimal parameter. The optimal parameter value depends on specific task and dose level. 2) There is a clear trade-off between CNR and resolution. The parameter for the best CNR is always smaller than that for the best resolution. 3) Optimal parameters are also dose-specific. Data acquired under a high dose protocol require less regularization, yielding smaller optimal parameter values. 4) Comparing with conventional FDK images, TF-based CBCT images are better under a certain optimally selected parameters. The advantages are more obvious for low dose data. Conclusion: We have investigated the relationship between image quality and parameter values in the TF-based IR algorithm. Preliminary results indicate optimal parameters are specific to both the task types and dose levels, providing guidance for selecting parameters in advanced IR algorithms. This work is supported in part by NIH (1R01CA154747-01)« less

  7. Locomotor Recovery in Spinal Cord Injury: Insights Beyond Walking Speed and Distance.

    PubMed

    Awai, Lea; Curt, Armin

    2016-08-01

    Recovery of locomotor function after incomplete spinal cord injury (iSCI) is clinically assessed through walking speed and distance, while improvements in these measures might not be in line with a normalization of gait quality and are, on their own, insensitive at revealing potential mechanisms underlying recovery. The objective of this study was to relate changes of gait parameters to the recovery of walking speed while distinguishing between parameters that rather reflect speed improvements from factors contributing to overall recovery. Kinematic data of 16 iSCI subjects were repeatedly recorded during in-patient rehabilitation. The responsiveness of gait parameters to walking speed was assessed by linear regression. Principal component analysis (PCA) was applied on the multivariate data across time to identify factors that contribute to recovery after iSCI. Parameters of gait cycle and movement dynamics were both responsive and closely related to the recovery of walking speed, which increased by 96%. Multivariate analysis revealed specific gait parameters (intralimb shape normality and consistency) that, although less related to speed increments, loaded highly on principal component one (PC1) (58.6%) explaining the highest proportion of variance (i.e., recovery of outcome over time). Interestingly, measures of hip, knee, and ankle range of motion showed varying degrees of responsiveness (from very high to very low) while not contributing to gait recovery as revealed by PCA. The conjunct application of two analysis methods distinguishes gait parameters that simply reflect increased walking speed from parameters that actually contribute to gait recovery in iSCI. This distinction may be of value for the evaluation of interventions for locomotor recovery.

  8. Spectral Induced Polarization monitoring of the groundwater physico-chemical parameters daily variations for stream-groundwater interactions

    NASA Astrophysics Data System (ADS)

    Jougnot, Damien; Camerlynck, Christian; Robain, Henri; Tallec, Gaëlle; Ribolzi, Olivier; Gaillardet, Jérôme

    2017-04-01

    During the last decades, geophysical methods have been attracting an increasing interest in hydrology and environmental sciences given their sensitivity to parameters of interests and their non-intrusive nature. The Spectral Induced Polarization (SIP) is a low frequency electro-magnetic method that allows the characterization of the subsurface through its complex electrical conductivity. It reports the modulus of the conductivity and the phase between an injected current and a measured voltage over a rather large frequency range (from few millihertz to few tens of kilohertz). The real part of the conductivity is sensitive to lithological (porosity, specific surface area) and hydrological (water saturation, water salinity) parameters, while the imaginary part is linked to electrochemical polarizations, that have been shown to be largely influenced by the chemistry of the pore water. In the present contribution, we aim at better characterizing the exchanges between a stream and the surrounding groundwater using the SIP method and its sensitivity to pore water changes over time. Two sites from the OZCAR Research Infrastructure (French Critical Zone observatories) have been chosen for this study: the Houay Pano catchment (Laos) and the Orgeval catchment (France). These two sites have a good existing infrastructure and have been already studied extensively in terms of hydrology, geophysics, and hydrochemistry. They constitute perfect experimental sites to develop novel methodologies for the assessment of stream-groundwater exchanges. We propose to obtain a vertical description of the changes in complex electrical conductivity with depth based on SIP soundings undertaken with the multi-channel system SIP Fuchs III. We conducted a high-frequency monitoring close to a river stream (one vertical profiles every 30 min). In parallel, a high frequency monitoring of the physico-chemical parameters (temperature, conductivity, ionic concentrations) in the river stream has been performed. Relating the daily fluctuations of the groundwater complex conductivity and the river physico-chemical parameters could therefore establish a new proxy to characterize stream-groundwater interactions. In parallel to the field measurements, laboratory experiments have been conducted on soil samples from the two sites. These measurements provide a better understanding of the complex conductivity signature of the samples submitted to saturation and pore water physico-chemical changes. This work is in progress but the first results already show that the method has a real interest for the monitoring of daily variations of the physico-chemistry properties of the groundwater and their relations to those of the stream.

  9. Gravitational lensing and ghost images in the regular Bardeen no-horizon spacetimes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schee, Jan; Stuchlík, Zdeněk, E-mail: jan.schee@fpf.slu.cz, E-mail: zdenek.stuchlik@fpf.slu.cz

    We study deflection of light rays and gravitational lensing in the regular Bardeen no-horizon spacetimes. Flatness of these spacetimes in the central region implies existence of interesting optical effects related to photons crossing the gravitational field of the no-horizon spacetimes with low impact parameters. These effects occur due to existence of a critical impact parameter giving maximal deflection of light rays in the Bardeen no-horizon spacetimes. We give the critical impact parameter in dependence on the specific charge of the spacetimes, and discuss 'ghost' direct and indirect images of Keplerian discs, generated by photons with low impact parameters. The ghostmore » direct images can occur only for large inclination angles of distant observers, while ghost indirect images can occur also for small inclination angles. We determine the range of the frequency shift of photons generating the ghost images and determine distribution of the frequency shift across these images. We compare them to those of the standard direct images of the Keplerian discs. The difference of the ranges of the frequency shift on the ghost and direct images could serve as a quantitative measure of the Bardeen no-horizon spacetimes. The regions of the Keplerian discs giving the ghost images are determined in dependence on the specific charge of the no-horizon spacetimes. For comparison we construct direct and indirect (ordinary and ghost) images of Keplerian discs around Reissner-Nördström naked singularities demonstrating a clear qualitative difference to the ghost direct images in the regular Bardeen no-horizon spacetimes. The optical effects related to the low impact parameter photons thus give clear signature of the regular Bardeen no-horizon spacetimes, as no similar phenomena could occur in the black hole or naked singularity spacetimes. Similar direct ghost images have to occur in any regular no-horizon spacetimes having nearly flat central region.« less

  10. Indexing of exoplanets in search for potential habitability: application to Mars-like worlds

    NASA Astrophysics Data System (ADS)

    Kashyap Jagadeesh, Madhu; Gudennavar, Shivappa B.; Doshi, Urmi; Safonova, Margarita

    2017-08-01

    Study of exoplanets is one of the main goals of present research in planetary sciences and astrobiology. Analysis of huge planetary data from space missions such as CoRoT and Kepler is directed ultimately at finding a planet similar to Earth—the Earth's twin, and answering the question of potential exo-habitability. The Earth Similarity Index (ESI) is a first step in this quest, ranging from 1 (Earth) to 0 (totally dissimilar to Earth). It was defined for the four physical parameters of a planet: radius, density, escape velocity and surface temperature. The ESI is further sub-divided into interior ESI (geometrical mean of radius and density) and surface ESI (geometrical mean of escape velocity and surface temperature). The challenge here is to determine which exoplanet parameter(s) is important in finding this similarity; how exactly the individual parameters entering the interior ESI and surface ESI are contributing to the global ESI. Since the surface temperature entering surface ESI is a non-observable quantity, it is difficult to determine its value. Using the known data for the Solar System objects, we established the calibration relation between surface and equilibrium temperatures to devise an effective way to estimate the value of the surface temperature of exoplanets. ESI is a first step in determining potential exo-habitability that may not be very similar to a terrestrial life. A new approach, called Mars Similarity Index (MSI), is introduced to identify planets that may be habitable to the extreme forms of life. MSI is defined in the range between 1 (present Mars) and 0 (dissimilar to present Mars) and uses the same physical parameters as ESI. We are interested in Mars-like planets to search for planets that may host the extreme life forms, such as the ones living in extreme environments on Earth; for example, methane on Mars may be a product of the methane-specific extremophile life form metabolism.

  11. Controlling chitosan-based encapsulation for protein and vaccine delivery

    PubMed Central

    Koppolu, Bhanu prasanth; Smith, Sean G.; Ravindranathan, Sruthi; Jayanthi, Srinivas; Kumar, Thallapuranam K.S.; Zaharoff, David A.

    2014-01-01

    Chitosan-based nano/microencapsulation is under increasing investigation for the delivery of drugs, biologics and vaccines. Despite widespread interest, the literature lacks a defined methodology to control chitosan particle size and drug/protein release kinetics. In this study, the effects of precipitation-coacervation formulation parameters on chitosan particle size, protein encapsulation efficiency and protein release were investigated. Chitosan particle sizes, which ranged from 300 nm to 3 μm, were influenced by chitosan concentration, chitosan molecular weight and addition rate of precipitant salt. The composition of precipitant salt played a significant role in particle formation with upper Hofmeister series salts containing strongly hydrated anions yielding particles with a low polydispersity index (PDI) while weaker anions resulted in aggregated particles with high PDIs. Sonication power had minimal effect on mean particle size, however, it significantly reduced polydispersity. Protein loading efficiencies in chitosan nano/microparticles, which ranged from 14.3% to 99.2%, was inversely related to the hydration strength of precipitant salts, protein molecular weight and directly related to the concentration and molecular weight of chitosan. Protein release rates increased with particle size and were generally inversely related to protein molecular weight. This study demonstrates that chitosan nano/microparticles with high protein loading efficiencies can be engineered with well-defined sizes and controllable release kinetics through manipulation of specific formulation parameters. PMID:24560459

  12. Isotopic dependence of fusion enhancement of various heavy ion systems using energy dependent Woods-Saxon potential

    NASA Astrophysics Data System (ADS)

    Gautam, Manjeet Singh

    2015-01-01

    In the present work, the fusion of symmetric and asymmetric projectile-target combinations are deeply analyzed within the framework of energy dependent Woods-Saxon potential model (EDWSP model) in conjunction with one dimensional Wong formula and the coupled channel code CCFULL. The neutron transfer channels and the inelastic surface excitations of collision partners are dominating mode of couplings and the coupling of relative motion of colliding nuclei to such relevant internal degrees of freedom produces a significant fusion enhancement at sub-barrier energies. It is quite interesting that the effects of dominant intrinsic degrees of freedom such as multi-phonon vibrational states, neutron transfer channels and proton transfer channels can be simulated by introducing the energy dependence in the nucleus-nucleus potential (EDWSP model). In the EDWSP model calculations, a wide range of diffuseness parameter ranging from a = 0.85 fm to a = 0.97 fm, which is much larger than a value (a = 0.65 fm) extracted from the elastic scattering data, is needed to reproduce sub-barrier fusion data. However, such diffuseness anomaly, which might be an artifact of some dynamical effects, has been resolved by trajectory fluctuation dissipation (TFD) model wherein the resulting nucleus-nucleus potential possesses normal diffuseness parameter.

  13. Toward a Unified View of Black-Hole High-Energy States

    NASA Technical Reports Server (NTRS)

    Nowak, Michael A.

    1995-01-01

    We present here a review of high-energy (greater than 1 keV) observations of seven black-hole candidates, six of which have estimated masses. In this review we focus on two parameters of interest: the ratio of 'nonthermal' to total luminosity as a function of the total luminosity divided by the Eddington luminosity, and the root-mean-square (rms) variability as a function of the nonthermal-to-total luminosity ratio. Below approx. 10% Eddington luminosity, the sources tend to be strictly nonthermal (the so called 'off' and 'low' states). Above this luminosity the sources become mostly thermal (the 'high' state). with the nonthermal component increasing with luminosity (the 'very high' and 'flare' states). There are important exceptions to this behavior, however, and no steady - as opposed to transient - source has been observed over a wide range of parameter space. In addition, the rms variability is positively correlated with the ratio of nonthermal to total luminosity, although there may be a minimum level of variability associated with 'thermal' states. We discuss these results in light of theoretical models and find that currently no single model describes the full range of black-hole high-energy behavior. In fact, the observations are exactly opposite from what one expects based upon simple notions of accretion disk instabilities.

  14. Anisotropy and applied-field effects on the spiral magnetic coexistence state of ferromagnetic superconductors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rose, G.H.

    1988-01-01

    The effect of three types of quartic anisotropy energy on the polarization of the spiral-magnetic state of Blount and Varma is studied near the onset temperature. A quartic anisotropy with uniaxial symmetry and a quartic anisotropy with cubic symmetry are studied, and the anisotropy in primitive tetragonal ErRh{sub 4}B{sub 4} is modeled with a quadratic anisotropy giving a hard c-axis, plus a quartic anisotropy in the basal plane with a square symmetry. Details of the magnetizations, wave vectors, and polarizations are presented. Further, using a variational approach, the author investigates the effects, in a slab geometry, of an infinitesimal andmore » finite magnetic field applied parallel to the slab on the spiral magnetic state. By additionally calculating the effects on the normal ferroparamagnetic state and the uniform superconducting state, he studies applied field vs. temperature phase diagrams. Due to the large experimental uncertainty in the material parameters, an extended range of values is studied, producing a number of interesting and physically unique phase diagrams. A categorization of the types of phase diagrams over the selected range of the material parameters is presented. Finally, the effective superconducting penetration depth in the presence of the spiral magnetic state is calculated.« less

  15. Performance limitations of a white light extrinsic Fabry-Perot interferometric displacement sensor

    NASA Astrophysics Data System (ADS)

    Moro, Erik A.; Todd, Michael D.; Puckett, Anthony D.

    2012-06-01

    Non-contacting interferometric fiber optic sensors offer a minimally invasive, high-accuracy means of measuring a structure's kinematic response to loading. The performance of interferometric sensors is often dictated by the technique employed for demodulating the kinematic measurand of interest from phase in the observed optical signal. In this paper a white-light extrinsic Fabry-Perot interferometer is implemented, offering robust displacement sensing performance. Displacement data is extracted from an estimate of the power spectral density, calculated from the interferometer's received optical power measured as a function of optical transmission frequency, and the sensor's performance is dictated by the details surrounding the implementation of this power spectral density estimation. One advantage of this particular type of interferometric sensor is that many of its control parameters (e.g., frequency range, frequency sampling density, sampling rate, etc.) may be chosen to so that the sensor satisfies application-specific performance needs in metrics such as bandwidth, axial displacement range, displacement resolution, and accuracy. A suite of user-controlled input values is investigated for estimating the spectrum of power versus wavelength data, and the relationships between performance metrics and input parameters are described in an effort to characterize the sensor's operational performance limitations. This work has been approved by Los Alamos National Laboratory for unlimited public release (LA-UR 12-01512).

  16. Model-Assisted Estimation of the Genetic Variability in Physiological Parameters Related to Tomato Fruit Growth under Contrasted Water Conditions

    PubMed Central

    Constantinescu, Dario; Memmah, Mohamed-Mahmoud; Vercambre, Gilles; Génard, Michel; Baldazzi, Valentina; Causse, Mathilde; Albert, Elise; Brunel, Béatrice; Valsesia, Pierre; Bertin, Nadia

    2016-01-01

    Drought stress is a major abiotic stress threatening plant and crop productivity. In case of fleshy fruits, understanding mechanisms governing water and carbon accumulations and identifying genes, QTLs and phenotypes, that will enable trade-offs between fruit growth and quality under Water Deficit (WD) condition is a crucial challenge for breeders and growers. In the present work, 117 recombinant inbred lines of a population of Solanum lycopersicum were phenotyped under control and WD conditions. Plant water status, fruit growth and composition were measured and data were used to calibrate a process-based model describing water and carbon fluxes in a growing fruit as a function of plant and environment. Eight genotype-dependent model parameters were estimated using a multiobjective evolutionary algorithm in order to minimize the prediction errors of fruit dry and fresh mass throughout fruit development. WD increased the fruit dry matter content (up to 85%) and decreased its fresh weight (up to 60%), big fruit size genotypes being the most sensitive. The mean normalized root mean squared errors of the predictions ranged between 16–18% in the population. Variability in model genotypic parameters allowed us to explore diverse genetic strategies in response to WD. An interesting group of genotypes could be discriminated in which (i) the low loss of fresh mass under WD was associated with high active uptake of sugars and low value of the maximum cell wall extensibility, and (ii) the high dry matter content in control treatment (C) was associated with a slow decrease of mass flow. Using 501 SNP markers genotyped across the genome, a QTL analysis of model parameters allowed to detect three main QTLs related to xylem and phloem conductivities, on chromosomes 2, 4, and 8. The model was then applied to design ideotypes with high dry matter content in C condition and low fresh mass loss in WD condition. The ideotypes outperformed the RILs especially for large and medium fruit-size genotypes, by combining high pedicel conductance and high active uptake of sugars. Interestingly, five small fruit-size RILs were close to the selected ideotypes, and likely bear interesting traits and alleles for adaptation to WD. PMID:28018381

  17. Improving phylogenetic analyses by incorporating additional information from genetic sequence databases.

    PubMed

    Liang, Li-Jung; Weiss, Robert E; Redelings, Benjamin; Suchard, Marc A

    2009-10-01

    Statistical analyses of phylogenetic data culminate in uncertain estimates of underlying model parameters. Lack of additional data hinders the ability to reduce this uncertainty, as the original phylogenetic dataset is often complete, containing the entire gene or genome information available for the given set of taxa. Informative priors in a Bayesian analysis can reduce posterior uncertainty; however, publicly available phylogenetic software specifies vague priors for model parameters by default. We build objective and informative priors using hierarchical random effect models that combine additional datasets whose parameters are not of direct interest but are similar to the analysis of interest. We propose principled statistical methods that permit more precise parameter estimates in phylogenetic analyses by creating informative priors for parameters of interest. Using additional sequence datasets from our lab or public databases, we construct a fully Bayesian semiparametric hierarchical model to combine datasets. A dynamic iteratively reweighted Markov chain Monte Carlo algorithm conveniently recycles posterior samples from the individual analyses. We demonstrate the value of our approach by examining the insertion-deletion (indel) process in the enolase gene across the Tree of Life using the phylogenetic software BALI-PHY; we incorporate prior information about indels from 82 curated alignments downloaded from the BAliBASE database.

  18. Ecocultural range-expansion scenarios for the replacement or assimilation of Neanderthals by modern humans.

    PubMed

    Wakano, Joe Yuichiro; Gilpin, William; Kadowaki, Seiji; Feldman, Marcus W; Aoki, Kenichi

    2018-02-01

    Recent archaeological records no longer support a simple dichotomous characterization of the cultures/behaviors of Neanderthals and modern humans, but indicate much cultural/behavioral variability over time and space. Thus, in modeling the replacement or assimilation of Neanderthals by modern humans, it is of interest to consider cultural dynamics and their relation to demographic change. The ecocultural framework for the competition between hominid species allows their carrying capacities to depend on some measure of the levels of culture they possess. In the present study both population densities and the densities of skilled individuals in Neanderthals and modern humans are spatially distributed and subject to change by spatial diffusion, ecological competition, and cultural transmission within each species. We analyze the resulting range expansions in terms of the demographic, ecological and cultural parameters that determine how the carrying capacities relate to the local densities of skilled individuals in each species. Of special interest is the case of cognitive and intrinsic-demographic equivalence of the two species. The range expansion dynamics may consist of multiple wave fronts of different speeds, each of which originates from a traveling wave solution. Properties of these traveling wave solutions are mathematically derived. Depending on the parameters, these traveling waves can result in replacement of Neanderthals by modern humans, or assimilation of the former by the latter. In both the replacement and assimilation scenarios, the first wave of intrusive modern humans is characterized by a low population density and a low density of skilled individuals, with implications for archaeological visibility. The first invasion is due to weak interspecific competition. A second wave of invasion may be induced by cultural differences between moderns and Neanderthals. Spatially and temporally extended coexistence of the two species, which would have facilitated the transfer of genes from Neanderthal into modern humans and vice versa, is observed in the traveling waves, except when niche overlap between the two species is extremely high. Archaeological findings on the spatial and temporal distributions of the Initial Upper Palaeolithic and the Early Upper Palaeolithic and of the coexistence of Neanderthals and modern humans are discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. A manual-based group program to improve mental health: what kind of teachers are interested and who stands to benefit from this program?

    PubMed

    Unterbrink, Thomas; Pfeifer, Ruth; Krippeit, Lorena; Zimmermann, Linda; Rose, Uwe; Joos, Andreas; Hartmann, Armin; Wirsching, Michael; Bauer, Joachim

    2014-01-01

    In order to evaluate a manual-based group program for teachers aiming at strengthening mental health, we examined (1) whether the teachers interested in participating differ from their colleagues without interest and (2) whether there is evidence of subgroups benefiting more than others among those who participated. Out of a basic sample of 949 schoolteachers, 337 teachers declared interest in a group program. All teachers were surveyed with the "General Health Questionnaire", the "Maslach Burnout Inventory" and the "Effort Reward Imbalance Questionnaire". In addition, participating teachers were screened with the "Symptom Checklist 27" T and χ(2)-tests were calculated to detect differences between those interested in the program and the remaining 612 teachers. Six factors were established and used for a regression analysis that identified specific parameters more or less correlating with health benefits of those who participated in the program. Findings showed that those declaring interest in the intervention displayed a higher degree of occupational stress according to all health parameters examined. Teachers interested in the program were significantly younger, more frequently female and single. The regression analysis showed that the baseline scores of the six health parameters were the strongest predictors for improvement. Worse scores before the beginning of the intervention correlated with a more positive effect. Intervention programs aiming at alleviating the mental stress of teachers find the interest of those who need it most. More importantly, the latter are the ones who--at least if our program is applied-benefit best.

  20. Magneto hall effect on unsteady elastico-viscous nanofluid slip flow in a channel in presence of thermal radiation and heat generation with Brownian motion

    NASA Astrophysics Data System (ADS)

    Karim, M. Enamul; Samad, M. Abdus; Ferdows, M.

    2017-06-01

    The present note investigates the magneto hall effect on unsteady flow of elastico-viscous nanofluid in a channel with slip boundary considering the presence of thermal radiation and heat generation with Brownian motion. Numerical results are achieved by solving the governing equations by the implicit Finite Difference Method (FDM) obtaining primary and secondary velocities, temperature, nanoparticles volume fraction and concentration distributions within the boundary layer entering into the problem. The influences of several interesting parameters such as elastico-viscous parameter, magnetic field, hall parameter, heat generation, thermal radiation and Brownian motion parameters on velocity, heat and mass transfer characteristics of the fluid flow are discussed with the help of graphs. Also the effects of the pertinent parameters, which are of physical and engineering interest, such as Skin friction parameter, Nusselt number and Sherwood number are sorted out. It is found that the flow field and other quantities of physical concern are significantly influenced by these parameters.

  1. Modeling pattern in collections of parameters

    USGS Publications Warehouse

    Link, W.A.

    1999-01-01

    Wildlife management is increasingly guided by analyses of large and complex datasets. The description of such datasets often requires a large number of parameters, among which certain patterns might be discernible. For example, one may consider a long-term study producing estimates of annual survival rates; of interest is the question whether these rates have declined through time. Several statistical methods exist for examining pattern in collections of parameters. Here, I argue for the superiority of 'random effects models' in which parameters are regarded as random variables, with distributions governed by 'hyperparameters' describing the patterns of interest. Unfortunately, implementation of random effects models is sometimes difficult. Ultrastructural models, in which the postulated pattern is built into the parameter structure of the original data analysis, are approximations to random effects models. However, this approximation is not completely satisfactory: failure to account for natural variation among parameters can lead to overstatement of the evidence for pattern among parameters. I describe quasi-likelihood methods that can be used to improve the approximation of random effects models by ultrastructural models.

  2. Beyond activity tracking: next-generation wearable and implantable sensor technologies (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Mercier, Patrick

    2017-05-01

    Current-generation wearable devices have had success continuously measuring the activity and heart rate of subjects during exercise and daily life activities, resulting in interesting new data sets that can, though machine learning algorithms, predict a small subset of health conditions. However, this information is only very peripherally related to most health conditions, and thus offers limited utility to a wide range of the population. In this presentation, I will discuss emerging sensor technologies capable of measuring new and interesting parameters that can potentially offer much more meaningful and actionable data sets. Specifically, I will present recent work on wearable chemical sensors that can, for the first time, continuously monitor a suite of parameters like glucose, alcohol, lactate, and electrolytes, all while wirelessly delivering these results to a smart phone in real time. Demonstration platforms featuring patch, temporary tattoo, and mouthguard form factors will be described, in addition to the corresponding electronics necessary to perform sensor conditioning and wireless readout. Beyond chemical sensors, I will also discuss integration strategies with more conventional electrophysiological and physical parameters like ECG and strain gauges for cardiac and respiration rate monitoring, respectively. Finally, I will conclude the talk by introducing a new form of wireless communications in body-area networks that utilize the body itself as a channel for magnetic energy. Since the power consumption of conventional RF circuits often dominates the power of wearable devices, this new magnetic human body communication technique is specifically architected to dramatically reduce the path loss compared to conventional RF and capacitive human body communication techniques, thereby enabling ultra-low-power body area networks for next-generation wearable devices.

  3. CO OBSERVATIONS AND INVESTIGATION OF TRIGGERED STAR FORMATION TOWARD THE N10 INFRARED BUBBLE AND SURROUNDINGS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gama, D. R. G.; Lepine, J. R. D.; Mendoza, E.

    We studied the environment of the dust bubble N10 in molecular emission. Infrared bubbles, first detected by the GLIMPSE survey at 8.0 μ m, are ideal regions to investigate the effect of the expansion of the H ii region on its surroundings and the eventual triggering of star formation at its borders. In this work, we present a multi-wavelength study of N10. This bubble is especially interesting because infrared studies of the young stellar content suggest a scenario of ongoing star formation, possibly triggered on the edge of the H ii region. We carried out observations of {sup 12}CO(1-0) andmore » {sup 13}CO(1-0) emission at PMO 13.7 m toward N10. We also analyzed the IR and sub-millimeter emission on this region and compare those different tracers to obtain a detailed view of the interaction between the expanding H ii region and the molecular gas. We also estimated the parameters of the denser cold dust condensation and the ionized gas inside the shell. Bright CO emission was detected and two molecular clumps were identified from which we have derived physical parameters. We also estimate the parameters for the densest cold dust condensation and for the ionized gas inside the shell. The comparison between the dynamical age of this region and the fragmentation timescale favors the “Radiation-Driven Implosion” mechanism of star formation. N10 is a case of particular interest with gas structures in a narrow frontier between the H ii region and surrounding molecular material, and with a range of ages of YSOs situated in the region, indicating triggered star formation.« less

  4. Assessing Sexual Dicromatism: The Importance of Proper Parameterization in Tetrachromatic Visual Models

    PubMed Central

    Janisse, Kevyn; Doucet, Stéphanie M.

    2017-01-01

    Perceptual models of animal vision have greatly contributed to our understanding of animal-animal and plant-animal communication. The receptor-noise model of color contrasts has been central to this research as it quantifies the difference between two colors for any visual system of interest. However, if the properties of the visual system are unknown, assumptions regarding parameter values must be made, generally with unknown consequences. In this study, we conduct a sensitivity analysis of the receptor-noise model using avian visual system parameters to systematically investigate the influence of variation in light environment, photoreceptor sensitivities, photoreceptor densities, and light transmission properties of the ocular media and the oil droplets. We calculated the chromatic contrast of 15 plumage patches to quantify a dichromatism score for 70 species of Galliformes, a group of birds that display a wide range of sexual dimorphism. We found that the photoreceptor densities and the wavelength of maximum sensitivity of the short-wavelength-sensitive photoreceptor 1 (SWS1) can change dichromatism scores by 50% to 100%. In contrast, the light environment, transmission properties of the oil droplets, transmission properties of the ocular media, and the peak sensitivities of the cone photoreceptors had a smaller impact on the scores. By investigating the effect of varying two or more parameters simultaneously, we further demonstrate that improper parameterization could lead to differences between calculated and actual contrasts of more than 650%. Our findings demonstrate that improper parameterization of tetrachromatic visual models can have very large effects on measures of dichromatism scores, potentially leading to erroneous inferences. We urge more complete characterization of avian retinal properties and recommend that researchers either determine whether their species of interest possess an ultraviolet or near-ultraviolet sensitive SWS1 photoreceptor, or present models for both. PMID:28076391

  5. Sound radiation from a high speed axial flow fan due to the inlet turbulence quadrupole interaction

    NASA Technical Reports Server (NTRS)

    Goldstein, M. E.; Rosenbaum, B. M.; Albers, L. U.

    1974-01-01

    A formula is obtained for the total acoustic power spectra radiated out the front of the fan as a function of frequency. The formula involves the design parameters of the fan as well as the statistical properties of the incident turbulence. Numerical results are calculated for values of the parameters in the range of interest for quiet fans tested at the Lewis Research Center. As in the dipole analysis, when the turbulence correlation lengths become equal to the interblade spacing, the predicted spectra exhibit peaks around the blade passing frequency and its harmonics. There has recently been considerable conjecture about whether the stretching of turbulent eddies as they enter a stationary fan could result in the inlet turbulence being the dominant source of pure tones from nontranslating fans. The results of the current analysis show that, unless the turbulent eddies become quite elongated, this noise source contributes predominantly to the broadband spectrum.

  6. A near-infrared reflectance spectroscopic method for the direct analysis of several fodder-related chemical components in drumstick (Moringa oleifera Lam.) leaves.

    PubMed

    Zhang, Junjie; Li, Shuqi; Lin, Mengfei; Yang, Endian; Chen, Xiaoyang

    2018-05-01

    The drumstick tree has traditionally been used as foodstuff and fodder in several countries. Due to its high nutritional value and good biomass production, interest in this plant has increased in recent years. It has therefore become important to rapidly and accurately evaluate drumstick quality. In this study, we addressed the optimization of Near-infrared spectroscopy (NIRS) to analyze crude protein, crude fat, crude fiber, iron (Fe), and potassium (K) in a variety of drumstick accessions (N = 111) representing different populations, cultivation programs, and climates. Partial least-squares regression with internal cross-validation was used to evaluate the models and identify possible spectral outliers. The calibration statistics for these fodder-related chemical components suggest that NIRS can predict these parameters in a wide range of drumstick types with high accuracy. The NIRS calibration models developed in this study will be useful in predicting drumstick forage quality for these five quality parameters.

  7. Simulation of dendritic growth reveals necessary and sufficient parameters to describe the shapes of dendritic trees

    NASA Astrophysics Data System (ADS)

    Trottier, Olivier; Ganguly, Sujoy; Bowne-Anderson, Hugo; Liang, Xin; Howard, Jonathon

    For the last 120 years, the development of neuronal shapes has been of great interest to the scientific community. Over the last 30 years, significant work has been done on the molecular processes responsible for dendritic development. In our ongoing research, we use the class IV sensory neurons of the Drosophila melanogaster larva as a model system to understand the growth of dendritic arbors. Our main goal is to elucidate the mechanisms that the neuron uses to determine the shape of its dendritic tree. We have observed the development of the class IV neuron's dendritic tree in the larval stage and have concluded that morphogenesis is defined by 3 distinct processes: 1) branch growth, 2) branching and 3) branch retraction. As the first step towards understanding dendritic growth, we have implemented these three processes in a computational model. Our simulations are able to reproduce the branch length distribution, number of branches and fractal dimension of the class IV neurons for a small range of parameters.

  8. Features of the energy structure of acoustic fields in the ocean with two-dimensional random inhomogeneities

    NASA Astrophysics Data System (ADS)

    Gulin, O. E.; Yaroshchuk, I. O.

    2017-03-01

    The paper is devoted to the analytic study and numerical simulation of mid-frequency acoustic signal propagation in a two-dimensional inhomogeneous random shallow-water medium. The study was carried out by the cross section method (local modes). We present original theoretical estimates for the behavior of the average acoustic field intensity and show that at different distances, the features of propagation loss behavior are determined by the intensity of fluctuations and their horizontal scale and depend on the initial regular parameters, such as the emission frequency and size of sound losses in the bottom. We establish analytically that for the considered waveguide and sound frequency parameters, mode coupling effect has a local character and weakly influences the statistics. We establish that the specific form of the spatial spectrum of sound velocity inhomogeneities for the statistical patterns of the field intensity is insignificant during observations in the range of shallow-water distances of practical interest.

  9. Ecotoxicology and spatial modeling in population dynamics: an illustration with brown trout.

    PubMed

    Chaumot, Arnaud; Charles, Sandrine; Flammarion, Patrick; Auger, Pierre

    2003-05-01

    We developed a multiregion matrix population model to explore how the demography of a hypothetical brown trout population living in a river network varies in response to different spatial scenarios of cadmium contamination. Age structure, spatial distribution, and demographic and migration processes are taken into account in the model. Chronic or acute cadmium concentrations affect the demographic parameters at the scale of the river range. The outputs of the model constitute population-level end points (the asymptotic population growth rate, the stable age structure, and the asymptotic spatial distribution) that allow comparing the different spatial scenarios of contamination regarding the demographic response at the scale of the whole river network. An analysis of the sensitivity of these end points to lower order parameters enables us to link the local effects of cadmium to the global demographic behavior of the brown trout population. Such a link is of broad interest in the point of view of ecotoxicological management.

  10. Rapidly rotating neutron stars with a massive scalar field—structure and universal relations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Doneva, Daniela D.; Yazadjiev, Stoytcho S., E-mail: daniela.doneva@uni-tuebingen.de, E-mail: yazad@phys.uni-sofia.bg

    We construct rapidly rotating neutron star models in scalar-tensor theories with a massive scalar field. The fact that the scalar field has nonzero mass leads to very interesting results since the allowed range of values of the coupling parameters is significantly broadened. Deviations from pure general relativity can be very large for values of the parameters that are in agreement with the observations. We found that the rapid rotation can magnify the differences several times compared to the static case. The universal relations between the normalized moment of inertia and quadrupole moment are also investigated both for the slowly andmore » rapidly rotating cases. The results show that these relations are still EOS independent up to a large extend and the deviations from pure general relativity can be large. This places the massive scalar-tensor theories amongst the few alternative theories of gravity that can be tested via the universal I -Love- Q relations.« less

  11. An experimental study of turbine vane heat transfer with leading edge and downstream film cooling

    NASA Astrophysics Data System (ADS)

    Nirmalan, V.; Hylton, L. D.

    1989-06-01

    This paper presents the effects of downstream film cooling, with and without leading edge showerhead film cooling, on turbine-vane external heat transfer. Steady-state experimental measurements were made in a three-vane linear two-dimensional cascade. The principal independent parameters were maintained over ranges consistent with actual engine conditions. The test matrix was structured to provide an assessment of the independent influence of parameters of interest, namely, exit Mach number, exit Reynolds number, coolant-to-gas temperature ratio, and coolant-to-gas pressure ratio. The data obtained indicate that considerable cooling benefits can be achieved by utilizing downstream film cooling. The downstream film cooling process was shown to be a complex interaction of two competing mechanisms. The thermal dilution effect, associated with the injection of relatively cold fluid, results in a decrease in the heat transfer to the airfoil. Conversely, the turbulence augmentation, produced by the injection process, results in increased heat transfer to the airfoil.

  12. Formability of a wrought Mg alloy evaluated by impression testing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mohamed, Walid; Gollapudi, Srikant; Charit, Indrajit

    This study is focused on furthering our understanding of the different factors that influence the formability of Magnesium alloys. Towards this end, formability studies were undertaken on a wrought Mg-2Zn-1Mn (ZM21) alloy. In contrast to conventional formability studies, the impression testing method was adopted here to evaluate the formability parameter, B, at temperatures ranging from 298 to 473 K. The variation of B of ZM21 with temperature and its rather limited values were discussed in the light of different deformation mechanisms such as activation of twinning, slip, grain boundary sliding (GBS) and dynamic recrystallization (DRX). It was found that themore » material characteristics such as grain size, texture and testing conditions such as temperature and strain rate, were key determinants of the mechanism of plastic deformation. A by-product of this analysis was the observation of an interesting correlation between the Zener-Hollomon parameter, Z, and the ability of Mg alloys to undergo DRX.« less

  13. Second and third harmonic generation associated to infrared transitions in a Morse quantum well under applied electric and magnetic fields

    NASA Astrophysics Data System (ADS)

    Restrepo, R. L.; Kasapoglu, E.; Sakiroglu, S.; Ungan, F.; Morales, A. L.; Duque, C. A.

    2017-09-01

    The effects of electric and magnetic fields on the second and third harmonic generation coefficients in a Morse potential quantum well are theoretically studied. The energy levels and corresponding wave functions are obtained by solving the Schrödinger equation for the electron in the parabolic band scheme and effective mass approximations and the envelope function approach. The results show that both the electric and the magnetic fields have significant influence on the magnitudes and resonant peak energy positions of the second and third harmonic generation responses. In general, the Morse potential profile becomes wider and shallower as γ -parameter increases and so the energies of the bound states will be functions of this parameter. Therefore, we can conclude that the effects of the electric and magnetic fields can be used to tune and control the optical properties of interest in the range of the infrared electromagnetic spectrum.

  14. Single- and multiple-pulse noncoherent detection statistics associated with partially developed speckle.

    PubMed

    Osche, G R

    2000-08-20

    Single- and multiple-pulse detection statistics are presented for aperture-averaged direct detection optical receivers operating against partially developed speckle fields. A partially developed speckle field arises when the probability density function of the received intensity does not follow negative exponential statistics. The case of interest here is the target surface that exhibits diffuse as well as specular components in the scattered radiation. An approximate expression is derived for the integrated intensity at the aperture, which leads to single- and multiple-pulse discrete probability density functions for the case of a Poisson signal in Poisson noise with an additive coherent component. In the absence of noise, the single-pulse discrete density function is shown to reduce to a generalized negative binomial distribution. The radar concept of integration loss is discussed in the context of direct detection optical systems where it is shown that, given an appropriate set of system parameters, multiple-pulse processing can be more efficient than single-pulse processing over a finite range of the integration parameter n.

  15. An experimental study of turbine vane heat transfer with leading edge and downstream film cooling

    NASA Technical Reports Server (NTRS)

    Nirmalan, V.; Hylton, L. D.

    1989-01-01

    This paper presents the effects of downstream film cooling, with and without leading edge showerhead film cooling, on turbine-vane external heat transfer. Steady-state experimental measurements were made in a three-vane linear two-dimensional cascade. The principal independent parameters were maintained over ranges consistent with actual engine conditions. The test matrix was structured to provide an assessment of the independent influence of parameters of interest, namely, exit Mach number, exit Reynolds number, coolant-to-gas temperature ratio, and coolant-to-gas pressure ratio. The data obtained indicate that considerable cooling benefits can be achieved by utilizing downstream film cooling. The downstream film cooling process was shown to be a complex interaction of two competing mechanisms. The thermal dilution effect, associated with the injection of relatively cold fluid, results in a decrease in the heat transfer to the airfoil. Conversely, the turbulence augmentation, produced by the injection process, results in increased heat transfer to the airfoil.

  16. The Cardassian expansion revisited: constraints from updated Hubble parameter measurements and type Ia supernova data

    NASA Astrophysics Data System (ADS)

    Magaña, Juan; Amante, Mario H.; Garcia-Aspeitia, Miguel A.; Motta, V.

    2018-05-01

    Motivated by an updated compilation of observational Hubble data (OHD) that consist of 51 points in the redshift range of 0.07 < z < 2.36, we study an interesting model known as Cardassian that drives the late cosmic acceleration without a dark energy component. Our compilation contains 31 data points measured with the differential age method by Jimenez & Loeb (2002), and 20 data points obtained from clustering of galaxies. We focus on two modified Friedmann equations: the original Cardassian (OC) expansion and the modified polytropic Cardassian (MPC). The dimensionless Hubble, E(z), and the deceleration parameter, q(z), are revisited in order to constrain the OC and MPC free parameters, first with the OHD and then contrasted with recent observations of type Ia supernova (SN Ia) using the compressed and full joint-light-analysis (JLA) samples (Betoule et al.). We also perform a joint analysis using the combination OHD plus compressed JLA. Our results show that the OC and MPC models are in agreement with the standard cosmology and naturally introduce a cosmological-constant-like extra term in the canonical Friedmann equation with the capability of accelerating the Universe without dark energy.

  17. Flexible Carbon Nanotube Films for High Performance Strain Sensors

    PubMed Central

    Kanoun, Olfa; Müller, Christian; Benchirouf, Abderahmane; Sanli, Abdulkadir; Dinh, Trong Nghia; Al-Hamry, Ammar; Bu, Lei; Gerlach, Carina; Bouhamed, Ayda

    2014-01-01

    Compared with traditional conductive fillers, carbon nanotubes (CNTs) have unique advantages, i.e., excellent mechanical properties, high electrical conductivity and thermal stability. Nanocomposites as piezoresistive films provide an interesting approach for the realization of large area strain sensors with high sensitivity and low manufacturing costs. A polymer-based nanocomposite with carbon nanomaterials as conductive filler can be deposited on a flexible substrate of choice and this leads to mechanically flexible layers. Such sensors allow the strain measurement for both integral measurement on a certain surface and local measurement at a certain position depending on the sensor geometry. Strain sensors based on carbon nanostructures can overcome several limitations of conventional strain sensors, e.g., sensitivity, adjustable measurement range and integral measurement on big surfaces. The novel technology allows realizing strain sensors which can be easily integrated even as buried layers in material systems. In this review paper, we discuss the dependence of strain sensitivity on different experimental parameters such as composition of the carbon nanomaterial/polymer layer, type of polymer, fabrication process and processing parameters. The insights about the relationship between film parameters and electromechanical properties can be used to improve the design and fabrication of CNT strain sensors. PMID:24915183

  18. Top-philic dark matter within and beyond the WIMP paradigm

    NASA Astrophysics Data System (ADS)

    Garny, Mathias; Heisig, Jan; Hufnagel, Marco; Lülf, Benedikt

    2018-04-01

    We present a comprehensive analysis of top-philic Majorana dark matter that interacts via a colored t -channel mediator. Despite the simplicity of the model—introducing three parameters only—it provides an extremely rich phenomenology allowing us to accommodate the relic density for a large range of coupling strengths spanning over 6 orders of magnitude. This model features all "exceptional" mechanisms for dark matter freeze-out, including the recently discovered conversion-driven freeze-out mode, with interesting signatures of long-lived colored particles at colliders. We constrain the cosmologically allowed parameter space with current experimental limits from direct, indirect and collider searches, with special emphasis on light dark matter below the top mass. In particular, we explore the interplay between limits from Xenon1T, Fermi-LAT and AMS-02 as well as limits from stop, monojet and Higgs invisible decay searches at the LHC. We find that several blind spots for light dark matter evade current constraints. The region in parameter space where the relic density is set by the mechanism of conversion-driven freeze-out can be conclusively tested by R -hadron searches at the LHC with 300 fb-1 .

  19. Multi-dimensional simulation package for ultrashort pulse laser-matter interactions

    NASA Astrophysics Data System (ADS)

    Suslova, Anastassiya; Hassanein, Ahmed

    2017-10-01

    Advanced simulation models recently became a popular tool of investigation of ultrashort pulse lasers (USPLs) to enhance understanding of the physics and allow minimizing the experimental costs for optimization of laser and target parameters for various applications. Our research interest is focused on developing multi-dimensional simulation package FEMTO-2D to investigate the USPL-matter interactions and laser induced effects. The package is based on solution of two heat conduction equations for electron and lattice sub-systems - enhanced two temperature model (TTM). We have implemented theoretical approach based on the collision theory to define the thermal dependence of target material optical properties and thermodynamic parameters. Our approach allowed elimination of fitted parameters commonly used in TTM based simulations. FEMTO-2D is used to simulated the light absorption and interactions for several metallic targets as a function of wavelength and pulse duration for wide range of laser intensity. The package has capability to consider different angles of incidence and polarization. It has also been used to investigate the damage threshold of the gold coated optical components with the focus on the role of the film thickness and substrate heat sink effect. This work was supported by the NSF, PIRE project.

  20. Low-frequency acousto-optic backscattering of Bessel light beams

    NASA Astrophysics Data System (ADS)

    Khilo, Nikolai A.; Belyi, Vladimir N.; Khilo, Petr A.; Kazak, Nikolai S.

    2018-05-01

    The use of Bessel light beams, as well as Bessel acoustic beams, substantially enhances the capabilities of acousto-optic methods for control of optical field. We present a theoretical study of the process of optical Bessel beams conversion by means of backward acousto-optic scattering on a Bessel acoustic field in a transversely isotropic crystal. It is shown that, with an appropriate choice of Bessel beams parameters, the backscattering in visible spectral range can be realized at relatively low acoustic frequencies less than one gigahertz. Under conditions of phase matching and transverse spatial synchronism, the efficiency of backscattering is sufficiently high, which is interesting, for example, for construction of acousto-optic spectral analyzers.

  1. Inertial frictional ratchets and their load bearing efficiencies

    NASA Astrophysics Data System (ADS)

    Kharkongor, D.; Reenbohn, W. L.; Mahato, Mangal C.

    2018-03-01

    We investigate the performance of an inertial frictional ratchet in a sinusoidal potential driven by a sinusoidal external field. The dependence of the performance on the parameters of the sinusoidally varying friction, such as the mean friction coefficient and its phase difference with the potential, is studied in detail. Interestingly, under certain circumstances, the thermodynamic efficiency of the ratchet against an applied load shows a non-monotonic behaviour as a function of the mean friction coefficient. Also, in the large friction ranges, the efficiency is shown to increase with increasing applied load even though the corresponding ratchet current decreases as the applied load increases. These counterintuitive numerical results are explained in the text.

  2. Anisotropic power-law inflation for a conformal-violating Maxwell model

    NASA Astrophysics Data System (ADS)

    Do, Tuan Q.; Kao, W. F.

    2018-05-01

    A set of power-law solutions of a conformal-violating Maxwell model with a non-standard scalar-vector coupling will be shown in this paper. In particular, we are interested in a coupling term of the form X^{2n} F^{μ ν }F_{μ ν } with X denoting the kinetic term of the scalar field. Stability analysis indicates that the new set of anisotropic power-law solutions is unstable during the inflationary phase. The result is consistent with the cosmic no-hair conjecture. We show, however, that a set of stable slowly expanding solutions does exist for a small range of parameters λ and n. Hence a small anisotropy can survive during the slowly expanding phase.

  3. Effective electrostatic interactions among charged thermo-responsive microgels immersed in a simple electrolyte

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    González-Mozuelos, P.

    This work explores the nature and thermodynamic behavior of the effective electrostatic interactions among charged microgels immersed in a simple electrolyte, taking special interest in the effects due to the thermally induced variation of the microgel size while the remaining parameters (microgel charge and concentration, plus the amount of added salt) are kept constant. To this end, the rigorous approach obtained from applying the precise methodology of the dressed ion theory to the proper definition of the effective direct correlation functions, which emerge from tracing-out the degrees of freedom of the microscopic ions, is employed to provide an exact descriptionmore » of the parameters characterizing such interactions: screening length, effective permittivity, and renormalized charges. A model solution with three components is assumed: large permeable anionic spheres for the microgels, plus small charged hard spheres of equal size for the monovalent cations and anions. The two-body correlations among the components of this model suspension, used as the input for the determination of the effective interaction parameters, are here calculated by using the hyper-netted chain approximation. It is then found that at finite microgel concentrations the values of these parameters change as the microgel size increases, even though the ionic strength of the supporting electrolyte and the bare charge of the microgels remain fixed during this process. The variation of the screening length, as well as that of the effective permittivity, is rather small, but still interesting in view of the fact that the corresponding Debye length stays constant. The renormalized charges, in contrast, increase markedly as the microgels swell. The ratio of the renormalized charge to the corresponding analytic result obtained in the context of an extended linear response theory allows us to introduce an effective charge that accounts for the non-linear effects induced by the short-ranged association of microions to the microgels. The behavior of these effective charges as a function of the amount of added salt and the macroion charge, size, and concentration reveals the interplay among all these system parameters.« less

  4. Minimal feedback to a rhythm generator improves the robustness to slope variations of a compass biped.

    PubMed

    Spitz, Jonathan; Evstrachin, Alexandrina; Zacksenhouse, Miriam

    2015-08-20

    In recent years there has been a growing interest in the field of dynamic walking and bio-inspired robots. However, while walking and running on a flat surface have been studied extensively, walking dynamically over terrains with varying slope remains a challenge. Previously we developed an open loop controller based on a central pattern generator (CPG). The controller applied predefined torque patterns to a compass-gait biped, and achieved stable gaits over a limited range of slopes. In this work, this range is greatly extended by applying a once per cycle feedback to the CPG controller. The terrain's slope is measured and used to modify both the CPG frequency and the torque amplitude once per step. A multi-objective optimization algorithm was used to tune the controller parameters for a simulated CB model. The resulting controller successfully traverses terrains with slopes ranging from +7° to -8°, comparable to most slopes found in human constructed environments. Gait stability was verified by computing the linearized Poincaré Map both numerically and analytically.

  5. Real-time Ensemble Forecasting of Coronal Mass Ejections using the WSA-ENLIL+Cone Model

    NASA Astrophysics Data System (ADS)

    Mays, M. L.; Taktakishvili, A.; Pulkkinen, A. A.; MacNeice, P. J.; Rastaetter, L.; Kuznetsova, M. M.; Odstrcil, D.

    2013-12-01

    Ensemble forecasting of coronal mass ejections (CMEs) provides significant information in that it provides an estimation of the spread or uncertainty in CME arrival time predictions due to uncertainties in determining CME input parameters. Ensemble modeling of CME propagation in the heliosphere is performed by forecasters at the Space Weather Research Center (SWRC) using the WSA-ENLIL cone model available at the Community Coordinated Modeling Center (CCMC). SWRC is an in-house research-based operations team at the CCMC which provides interplanetary space weather forecasting for NASA's robotic missions and performs real-time model validation. A distribution of n (routinely n=48) CME input parameters are generated using the CCMC Stereo CME Analysis Tool (StereoCAT) which employs geometrical triangulation techniques. These input parameters are used to perform n different simulations yielding an ensemble of solar wind parameters at various locations of interest (satellites or planets), including a probability distribution of CME shock arrival times (for hits), and geomagnetic storm strength (for Earth-directed hits). Ensemble simulations have been performed experimentally in real-time at the CCMC since January 2013. We present the results of ensemble simulations for a total of 15 CME events, 10 of which were performed in real-time. The observed CME arrival was within the range of ensemble arrival time predictions for 5 out of the 12 ensemble runs containing hits. The average arrival time prediction was computed for each of the twelve ensembles predicting hits and using the actual arrival time an average absolute error of 8.20 hours was found for all twelve ensembles, which is comparable to current forecasting errors. Some considerations for the accuracy of ensemble CME arrival time predictions include the importance of the initial distribution of CME input parameters, particularly the mean and spread. When the observed arrivals are not within the predicted range, this still allows the ruling out of prediction errors caused by tested CME input parameters. Prediction errors can also arise from ambient model parameters such as the accuracy of the solar wind background, and other limitations. Additionally the ensemble modeling setup was used to complete a parametric event case study of the sensitivity of the CME arrival time prediction to free parameters for ambient solar wind model and CME.

  6. Optimized enhancement in helical CT: experiences with a real-time bolus tracking system in 628 patients.

    PubMed

    Kirchner, J; Kickuth, R; Laufer, U; Noack, M; Liermann, D

    2000-05-01

    Ultrafast detector technology enables bolus-triggered application of contrast media. In a prospective study we investigated the benefit of this new method with the intention of optimizing enhancement during examination of the chest and abdomen. In total, we examined 548 patients under standardized conditions. All examinations were performed on a Somatom Plus 4 Power CT system (Siemens Corp., Forchheim, Germany) using the CARE-Bolus software. This produces repetitive low-dose test images (e.g. for the lung: 140 kV, 43 mA, TI 0.5 s) and measures the Hounsfield attenuation in a pre-selected region of interest. After exceeding a defined threshold, a diagnostic spiral CT examination was begun automatically. The data obtained from 321 abdominal CT and 179 lung CT examinations were correlated with different parameters such as age, weight and height of the patients and parameters of vascular access. In a group of 80 patients, the injection of contrast medium was stopped after reaching a pre-defined threshold of an increase of 100 HU over the baseline. Then, we assessed the maximal enhancement of liver, pulmonal artery trunk and aortic arch. There was no correlation between bolus geometry and age, body surface or weight. In helical CT of the abdomen the threshold was reached after a mean trigger time of 27 s (range 13-67 s) and only 65 ml (range 41-105 ml) of contrast medium were administered. In helical CT of the lung the threshold was reached after 21 s (range 12-48 s) and the mean amount of administered contrast medium was 48 ml (range 38-71 ml). Bolus triggering allows optimized enhancement of the organs and reduces the dose of contrast material required compared with standard administration. Copyright 2000 The Royal College of Radiologists.

  7. Application of Adaptive DP-optimality to Design a Pilot Study for a Clotting Time Test for Enoxaparin.

    PubMed

    Gulati, Abhishek; Faed, James M; Isbister, Geoffrey K; Duffull, Stephen B

    2015-10-01

    Dosing of enoxaparin, like other anticoagulants, may result in bleeding following excessive doses and clot formation if the dose is too low. We recently showed that a factor Xa based clotting time test could potentially assess the effect of enoxaparin on the clotting system. However, the test did not perform well in subsequent individuals and effectiveness of an exogenous phospholipid, Actin FS, in reducing the variability in the clotting time was assessed. The aim of this work was to conduct an adaptive pilot study to determine the range of concentrations of Xa and Actin FS to take forward into a proof-of-concept study. A nonlinear parametric function was developed to describe the response surface over the factors of interest. An adaptive method was used to estimate the parameters using a D-optimal design criterion. In order to provide a reasonable probability of observing a success of the clotting time test, a P-optimal design criterion was incorporated using a loss function to describe the hybrid DP-optimality. The use of adaptive DP-optimality method resulted in an efficient estimation of model parameters using data from only 6 healthy volunteers. The use of response surface modelling identified a range of sets of Xa and Actin FS concentrations, any of which could be used for the proof-of-concept study. This study shows that parsimonious adaptive DP-optimal designs may provide both precise parameter estimates for response surface modelling as well as clinical confidence in the potential benefits of the study.

  8. Bayesian parameter estimation in spectral quantitative photoacoustic tomography

    NASA Astrophysics Data System (ADS)

    Pulkkinen, Aki; Cox, Ben T.; Arridge, Simon R.; Kaipio, Jari P.; Tarvainen, Tanja

    2016-03-01

    Photoacoustic tomography (PAT) is an imaging technique combining strong contrast of optical imaging to high spatial resolution of ultrasound imaging. These strengths are achieved via photoacoustic effect, where a spatial absorption of light pulse is converted into a measurable propagating ultrasound wave. The method is seen as a potential tool for small animal imaging, pre-clinical investigations, study of blood vessels and vasculature, as well as for cancer imaging. The goal in PAT is to form an image of the absorbed optical energy density field via acoustic inverse problem approaches from the measured ultrasound data. Quantitative PAT (QPAT) proceeds from these images and forms quantitative estimates of the optical properties of the target. This optical inverse problem of QPAT is illposed. To alleviate the issue, spectral QPAT (SQPAT) utilizes PAT data formed at multiple optical wavelengths simultaneously with optical parameter models of tissue to form quantitative estimates of the parameters of interest. In this work, the inverse problem of SQPAT is investigated. Light propagation is modelled using the diffusion equation. Optical absorption is described with chromophore concentration weighted sum of known chromophore absorption spectra. Scattering is described by Mie scattering theory with an exponential power law. In the inverse problem, the spatially varying unknown parameters of interest are the chromophore concentrations, the Mie scattering parameters (power law factor and the exponent), and Gruneisen parameter. The inverse problem is approached with a Bayesian method. It is numerically demonstrated, that estimation of all parameters of interest is possible with the approach.

  9. Apparatus and method for mapping an area of interest

    DOEpatents

    Staab, Torsten A. Cohen, Daniel L.; Feller, Samuel [Fairfax, VA

    2009-12-01

    An apparatus and method are provided for mapping an area of interest using polar coordinates or Cartesian coordinates. The apparatus includes a range finder, an azimuth angle measuring device to provide a heading and an inclinometer to provide an angle of inclination of the range finder as it relates to primary reference points and points of interest. A computer is provided to receive signals from the range finder, inclinometer and azimuth angle measurer to record location data and calculate relative locations between one or more points of interest and one or more primary reference points. The method includes mapping of an area of interest to locate points of interest relative to one or more primary reference points and to store the information in the desired manner. The device may optionally also include an illuminator which can be utilized to paint the area of interest to indicate both points of interest and primary points of reference during and/or after data acquisition.

  10. Long-range propagation of plasmon and phonon polaritons in hyperbolic-metamaterial waveguides

    NASA Astrophysics Data System (ADS)

    Babicheva, Viktoriia E.

    2017-12-01

    We study photonic multilayer waveguides that include layers of materials and metamaterials with a hyperbolic dispersion (HMM). We consider the long-range propagation of plasmon and phonon polaritons at the dielectric-HMM interface in different waveguide geometries (single boundary or different layers of symmetric cladding). In contrast to the traditional analysis of geometrical parameters, we make an emphasis on the optical properties of constituent materials: solving dispersion equations, we analyze how dielectric and HMM permittivities affect propagation length and mode size of waveguide eigenmodes. We derive figures of merit that should be used for each waveguide in a broad range of permittivity values as well as compare them with plasmonic waveguides. We show that the conventional plasmonic quality factor, which is the ratio of real to imaginary parts of permittivity, is not applicable to the case of waveguides with complex structure. Both telecommunication wavelengths and mid-infrared spectral ranges are of interest considering recent advances in van der Waals materials, such as hexagonal boron nitride. We evaluate the performance of the waveguides with hexagonal boron nitride in the range where it possesses hyperbolic dispersion (wavelength 6.3-7.3 μm), and we show that these waveguides with natural hyperbolic properties have higher propagation lengths than metal-based HMM waveguides.

  11. Tracking Multiple Topics for Finding Interesting Articles

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pon, R K; Cardenas, A F; Buttler, D J

    We introduce multiple topic tracking (MTT) for iScore to better recommend news articles for users with multiple interests and to address changes in user interests over time. As an extension of the basic Rocchio algorithm, traditional topic detection and tracking, and single-pass clustering, MTT maintains multiple interest profiles to identify interesting articles for a specific user given user-feedback. Focusing on only interesting topics enables iScore to discard useless profiles to address changes in user interests and to achieve a balance between resource consumption and classification accuracy. Also by relating a topic's interestingness to an article's interestingness, iScore is able tomore » achieve higher quality results than traditional methods such as the Rocchio algorithm. We identify several operating parameters that work well for MTT. Using the same parameters, we show that MTT alone yields high quality results for recommending interesting articles from several corpora. The inclusion of MTT improves iScore's performance by 9% to 14% in recommending news articles from the Yahoo! News RSS feeds and the TREC11 adaptive filter article collection. And through a small user study, we show that iScore can still perform well when only provided with little user feedback.« less

  12. Utility usage forecasting

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hosking, Jonathan R. M.; Natarajan, Ramesh

    The computer creates a utility demand forecast model for weather parameters by receiving a plurality of utility parameter values, wherein each received utility parameter value corresponds to a weather parameter value. Determining that a range of weather parameter values lacks a sufficient amount of corresponding received utility parameter values. Determining one or more utility parameter values that corresponds to the range of weather parameter values. Creating a model which correlates the received and the determined utility parameter values with the corresponding weather parameters values.

  13. Estimating parameters of hidden Markov models based on marked individuals: use of robust design data

    USGS Publications Warehouse

    Kendall, William L.; White, Gary C.; Hines, James E.; Langtimm, Catherine A.; Yoshizaki, Jun

    2012-01-01

    Development and use of multistate mark-recapture models, which provide estimates of parameters of Markov processes in the face of imperfect detection, have become common over the last twenty years. Recently, estimating parameters of hidden Markov models, where the state of an individual can be uncertain even when it is detected, has received attention. Previous work has shown that ignoring state uncertainty biases estimates of survival and state transition probabilities, thereby reducing the power to detect effects. Efforts to adjust for state uncertainty have included special cases and a general framework for a single sample per period of interest. We provide a flexible framework for adjusting for state uncertainty in multistate models, while utilizing multiple sampling occasions per period of interest to increase precision and remove parameter redundancy. These models also produce direct estimates of state structure for each primary period, even for the case where there is just one sampling occasion. We apply our model to expected value data, and to data from a study of Florida manatees, to provide examples of the improvement in precision due to secondary capture occasions. We also provide user-friendly software to implement these models. This general framework could also be used by practitioners to consider constrained models of particular interest, or model the relationship between within-primary period parameters (e.g., state structure) and between-primary period parameters (e.g., state transition probabilities).

  14. Uncertainty analysis and global sensitivity analysis of techno-economic assessments for biodiesel production.

    PubMed

    Tang, Zhang-Chun; Zhenzhou, Lu; Zhiwen, Liu; Ningcong, Xiao

    2015-01-01

    There are various uncertain parameters in the techno-economic assessments (TEAs) of biodiesel production, including capital cost, interest rate, feedstock price, maintenance rate, biodiesel conversion efficiency, glycerol price and operating cost. However, fewer studies focus on the influence of these parameters on TEAs. This paper investigated the effects of these parameters on the life cycle cost (LCC) and the unit cost (UC) in the TEAs of biodiesel production. The results show that LCC and UC exhibit variations when involving uncertain parameters. Based on the uncertainty analysis, three global sensitivity analysis (GSA) methods are utilized to quantify the contribution of an individual uncertain parameter to LCC and UC. The GSA results reveal that the feedstock price and the interest rate produce considerable effects on the TEAs. These results can provide a useful guide for entrepreneurs when they plan plants. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Identifying sensitive ranges in global warming precipitation change dependence on convective parameters

    DOE PAGES

    Bernstein, Diana N.; Neelin, J. David

    2016-04-28

    A branch-run perturbed-physics ensemble in the Community Earth System Model estimates impacts of parameters in the deep convection scheme on current hydroclimate and on end-of-century precipitation change projections under global warming. Regional precipitation change patterns prove highly sensitive to these parameters, especially in the tropics with local changes exceeding 3mm/d, comparable to the magnitude of the predicted change and to differences in global warming predictions among the Coupled Model Intercomparison Project phase 5 models. This sensitivity is distributed nonlinearly across the feasible parameter range, notably in the low-entrainment range of the parameter for turbulent entrainment in the deep convection scheme.more » This suggests that a useful target for parameter sensitivity studies is to identify such disproportionately sensitive dangerous ranges. Here, the low-entrainment range is used to illustrate the reduction in global warming regional precipitation sensitivity that could occur if this dangerous range can be excluded based on evidence from current climate.« less

  16. Identifying sensitive ranges in global warming precipitation change dependence on convective parameters

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bernstein, Diana N.; Neelin, J. David

    A branch-run perturbed-physics ensemble in the Community Earth System Model estimates impacts of parameters in the deep convection scheme on current hydroclimate and on end-of-century precipitation change projections under global warming. Regional precipitation change patterns prove highly sensitive to these parameters, especially in the tropics with local changes exceeding 3mm/d, comparable to the magnitude of the predicted change and to differences in global warming predictions among the Coupled Model Intercomparison Project phase 5 models. This sensitivity is distributed nonlinearly across the feasible parameter range, notably in the low-entrainment range of the parameter for turbulent entrainment in the deep convection scheme.more » This suggests that a useful target for parameter sensitivity studies is to identify such disproportionately sensitive dangerous ranges. Here, the low-entrainment range is used to illustrate the reduction in global warming regional precipitation sensitivity that could occur if this dangerous range can be excluded based on evidence from current climate.« less

  17. Strain relaxation in the epitaxy of La2/3Sr1/3MnO3 grown by pulsed-laser deposition on SrTiO3(001)

    NASA Astrophysics Data System (ADS)

    Maurice, J.-L.; Pailloux, F.; Barthélémy, A.; Durand, O.; Imhoff, D.; Lyonnet, R.; Rocher, A.; Contour, J.-P.

    2003-10-01

    With a Curie point at 370 K, the half-metal (La0.7Sr0.3)MnO3 (LSMO) is one of the most interesting candidates for electronic devices based on tunnel magnetoresistance. SrTiO3 (STO) is up to now the best substrate for the epitaxy of suitable thin films of LSMO. The pseudocubic unit cell of rhombohedral LSMO has a parameter aLSMO such that (aSTO m aLSMO)/aLSMO = + 0.83% (where aSTO is the parameter of cubic STO) and an angle of 90.26°. As strained growth is tetragonal, relaxation implies recovery of both the pseudocubic parameter and of the original angle. In the LSMO layers that we prepare by pulsed-laser deposition, we show that these two processes are quite independent. The angular distortion is partially recovered by twinning in films 25 nm thick, while recovery of the parameter never occurs in the thickness range that we explored (up to 432 nm). A relaxation, however, takes place above a thickness of 100 nm, associated with a transition from two-dimensional to three-dimensional columnar growth. It is accompanied by chemical fluctuations. Our magnetic measurements exhibit Curie temperatures and magnetic moments very close to the bulk values in those layers where the crystal parameter is strained but the angle partially relaxed.

  18. Fitted hyperelastic parameters for Human brain tissue from reported tension, compression, and shear tests.

    PubMed

    Moran, Richard; Smith, Joshua H; García, José J

    2014-11-28

    The mechanical properties of human brain tissue are the subject of interest because of their use in understanding brain trauma and in developing therapeutic treatments and procedures. To represent the behavior of the tissue, we have developed hyperelastic mechanical models whose parameters are fitted in accordance with experimental test results. However, most studies available in the literature have fitted parameters with data of a single type of loading, such as tension, compression, or shear. Recently, Jin et al. (Journal of Biomechanics 46:2795-2801, 2013) reported data from ex vivo tests of human brain tissue under tension, compression, and shear loading using four strain rates and four different brain regions. However, they do not report parameters of energy functions that can be readily used in finite element simulations. To represent the tissue behavior for the quasi-static loading conditions, we aimed to determine the best fit of the hyperelastic parameters of the hyperfoam, Ogden, and polynomial strain energy functions available in ABAQUS for the low strain rate data, while simultaneously considering all three loading modes. We used an optimization process conducted in MATLAB, calling iteratively three finite element models developed in ABAQUS that represent the three loadings. Results showed a relatively good fit to experimental data in all loading modes using two terms in the energy functions. Values for the shear modulus obtained in this analysis (897-1653Pa) are in the range of those presented in other studies. These energy-function parameters can be used in brain tissue simulations using finite element models. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. A General Approach for Specifying Informative Prior Distributions for PBPK Model Parameters

    EPA Science Inventory

    Characterization of uncertainty in model predictions is receiving more interest as more models are being used in applications that are critical to human health. For models in which parameters reflect biological characteristics, it is often possible to provide estimates of paramet...

  20. Pilot Mental Workload with Predictive System Status Information

    NASA Technical Reports Server (NTRS)

    Trujillo, Anna C.

    1998-01-01

    Research has shown a strong pilot preference for predictive information of aircraft system status in the flight deck. However, the mental workload associated with using this predictive information has not been ascertained. The study described here attempted to measure mental workload. In this simulator experiment, three types of predictive information (none, whether a parameter was changing abnormally, and the time for a parameter to reach an alert range) and four initial times to a parameter alert range (1 minute, 5 minutes, 15 minutes, and ETA+45 minutes) were tested to determine their effects on subjects mental workload. Subjective workload ratings increased with increasing predictive information (whether a parameter was changing abnormally or the time for a parameter to reach an alert range). Subjective situation awareness decreased with more predictive information but it became greater with increasing initial times to a parameter alert range. Also, subjective focus changed depending on the type of predictive information. Lastly, skin temperature fluctuated less as the initial time to a parameter alert range increased.

  1. Effects of expected-value information and display format on recognition of aircraft subsystem abnormalities

    NASA Technical Reports Server (NTRS)

    Palmer, Michael T.; Abbott, Kathy H.

    1994-01-01

    This study identifies improved methods to present system parameter information for detecting abnormal conditions and to identify system status. Two workstation experiments were conducted. The first experiment determined if including expected-value-range information in traditional parameter display formats affected subject performance. The second experiment determined if using a nontraditional parameter display format, which presented relative deviation from expected value, was better than traditional formats with expected-value ranges included. The inclusion of expected-value-range information onto traditional parameter formats was found to have essentially no effect. However, subjective results indicated support for including this information. The nontraditional column deviation parameter display format resulted in significantly fewer errors compared with traditional formats with expected-value-ranges included. In addition, error rates for the column deviation parameter display format remained stable as the scenario complexity increased, whereas error rates for the traditional parameter display formats with expected-value ranges increased. Subjective results also indicated that the subjects preferred this new format and thought that their performance was better with it. The column deviation parameter display format is recommended for display applications that require rapid recognition of out-of-tolerance conditions, especially for a large number of parameters.

  2. Automated Selection of Regions of Interest for Intensity-based FRET Analysis of Transferrin Endocytic Trafficking in Normal vs. Cancer Cells

    PubMed Central

    Talati, Ronak; Vanderpoel, Andrew; Eladdadi, Amina; Anderson, Kate; Abe, Ken; Barroso, Margarida

    2013-01-01

    The overexpression of certain membrane-bound receptors is a hallmark of cancer progression and it has been suggested to affect the organization, activation, recycling and down-regulation of receptor-ligand complexes in human cancer cells. Thus, comparing receptor trafficking pathways in normal vs. cancer cells requires the ability to image cells expressing dramatically different receptor expression levels. Here, we have presented a significant technical advance to the analysis and processing of images collected using intensity based Förster resonance energy transfer (FRET) confocal microscopy. An automated Image J macro was developed to select region of interests (ROI) based on intensity and statistical-based thresholds within cellular images with reduced FRET signal. Furthermore, SSMD (strictly standardized mean differences), a statistical signal-to-noise ratio (SNR) evaluation parameter, was used to validate the quality of FRET analysis, in particular of ROI database selection. The Image J ROI selection macro together with SSMD as an evaluation parameter of SNR levels, were used to investigate the endocytic recycling of Tfn-TFR complexes at nanometer range resolution in human normal vs. breast cancer cells expressing significantly different levels of endogenous TFR. Here, the FRET-based assay demonstrates that Tfn-TFR complexes in normal epithelial vs. breast cancer cells show a significantly different E% behavior during their endocytic recycling pathway. Since E% is a relative measure of distance, we propose that these changes in E% levels represent conformational changes in Tfn-TFR complexes during endocytic pathway. Thus, our results indicate that Tfn-TFR complexes undergo different conformational changes in normal vs. cancer cells, indicating that the organization of Tfn-TFR complexes at the nanometer range is significantly altered during the endocytic recycling pathway in cancer cells. In summary, improvements in the automated selection of FRET ROI datasets allowed us to detect significant changes in E% with potential biological significance in human normal vs. cancer cells. PMID:23994873

  3. Factorial experimental design for the culture of human embryonic stem cells as aggregates in stirred suspension bioreactors reveals the potential for interaction effects between bioprocess parameters.

    PubMed

    Hunt, Megan M; Meng, Guoliang; Rancourt, Derrick E; Gates, Ian D; Kallos, Michael S

    2014-01-01

    Traditional optimization of culture parameters for the large-scale culture of human embryonic stem cells (ESCs) as aggregates is carried out in a stepwise manner whereby the effect of varying each culture parameter is investigated individually. However, as evidenced by the wide range of published protocols and culture performance indicators (growth rates, pluripotency marker expression, etc.), there is a lack of systematic investigation into the true effect of varying culture parameters especially with respect to potential interactions between culture variables. Here we describe the design and execution of a two-parameter, three-level (3(2)) factorial experiment resulting in nine conditions that were run in duplicate 125-mL stirred suspension bioreactors. The two parameters investigated here were inoculation density and agitation rate, which are easily controlled, but currently, poorly characterized. Cell readouts analyzed included fold expansion, maximum density, and exponential growth rate. Our results reveal that the choice of best case culture parameters was dependent on which cell property was chosen as the primary output variable. Subsequent statistical analyses via two-way analysis of variance indicated significant interaction effects between inoculation density and agitation rate specifically in the case of exponential growth rates. Results indicate that stepwise optimization has the potential to miss out on the true optimal case. In addition, choosing an optimum condition for a culture output of interest from the factorial design yielded similar results when repeated with the same cell line indicating reproducibility. We finally validated that human ESCs remain pluripotent in suspension culture as aggregates under our optimal conditions and maintain their differentiation capabilities as well as a stable karyotype and strong expression levels of specific human ESC markers over several passages in suspension bioreactors.

  4. A new approach to modeling aerosol effects on East Asian climate: Parametric uncertainties associated with emissions, cloud microphysics, and their interactions: AEROSOL EFFECTS ON EAST ASIAN CLIMATE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yan, Huiping; Qian, Yun; Zhao, Chun

    2015-09-09

    In this study, we adopt a parametric sensitivity analysis framework that integrates the quasi-Monte Carlo parameter sampling approach and a surrogate model to examine aerosol effects on the East Asian Monsoon climate simulated in the Community Atmosphere Model (CAM5). A total number of 256 CAM5 simulations are conducted to quantify the model responses to the uncertain parameters associated with cloud microphysics parameterizations and aerosol (e.g., sulfate, black carbon (BC), and dust) emission factors and their interactions. Results show that the interaction terms among parameters are important for quantifying the sensitivity of fields of interest, especially precipitation, to the parameters. Themore » relative importance of cloud-microphysics parameters and emission factors (strength) depends on evaluation metrics or the model fields we focused on, and the presence of uncertainty in cloud microphysics imposes an additional challenge in quantifying the impact of aerosols on cloud and climate. Due to their different optical and microphysical properties and spatial distributions, sulfate, BC, and dust aerosols have very different impacts on East Asian Monsoon through aerosol-cloud-radiation interactions. The climatic effects of aerosol do not always have a monotonic response to the change of emission factors. The spatial patterns of both sign and magnitude of aerosol-induced changes in radiative fluxes, cloud, and precipitation could be different, depending on the aerosol types, when parameters are sampled in different ranges of values. We also identify the different cloud microphysical parameters that show the most significant impact on climatic effect induced by sulfate, BC and dust, respectively, in East Asia.« less

  5. Excitation of higher radial modes of azimuthal surface waves in the electron cyclotron frequency range by rotating relativistic flow of electrons in cylindrical waveguides partially filled by plasmas

    NASA Astrophysics Data System (ADS)

    Girka, Igor O.; Pavlenko, Ivan V.; Thumm, Manfred

    2018-05-01

    Azimuthal surface waves are electromagnetic eigenwaves of cylindrical plasma-dielectric waveguides which propagate azimuthally nearby the plasma-dielectric interface across an axial external stationary magnetic field. Their eigenfrequency in particular can belong to the electron cyclotron frequency range. Excitation of azimuthal surface waves by rotating relativistic electron flows was studied in detail recently in the case of the zeroth radial mode for which the waves' radial phase change within the layer where the electrons gyrate is small. In this case, just the plasma parameters cause the main influence on the waves' dispersion properties. In the case of the first and higher radial modes, the wave eigenfrequency is higher and the wavelength is shorter than in the case of the zeroth radial mode. This gain being of interest for practical applications can be achieved without any change in the device design. The possibility of effective excitation of the higher order radial modes of azimuthal surface waves is demonstrated here. Getting shorter wavelengths of the excited waves in the case of higher radial modes is shown to be accompanied by decreasing growth rates of the waves. The results obtained here are of interest for developing new sources of electromagnetic radiation, in nano-physics and in medical physics.

  6. An observational program to search for radio signals from extraterrestrial intelligence through the use of existing facilities

    NASA Technical Reports Server (NTRS)

    Edelson, R. E.

    1976-01-01

    It is argued that a substantial portion of the capability for detecting microwave signals from extraterrestrial civilizations lies not in the application of ever larger antenna collecting areas but rather in the application of millions or billions of simultaneous frequency-channel observations combined with rapid and powerful data processing techniques. The application of these methods to existing facilities is discussed in terms of a program of modest expense and duration which will seek to discover certain classes of extraterrestrial signals of intelligent origin while defining boundaries to the search problem throughout the range of interest. This program will investigate radio-astronomical phenomena of interest and simultaneously define the background of environmental radiation in order to determine physical limitations on both the search strategies and the potential for deep-space communications. Signal parameters that must be determined are examined along with the potential of existing radio-astronomical facilities for detecting narrow-band signals. A seven-year program is described which will carry out a search for extraterrestrial intelligence over 80% of the sky and over the entire frequency range from 1 to 25 GHz with a sensitivity limit varying from 10 to the -21st power W/sq cm at the lowest frequencies to 10 to the -19th power W/sq cm at the higher frequencies.

  7. Tuned dynamics stabilizes an idealized regenerative axial-torsional model of rotary drilling

    NASA Astrophysics Data System (ADS)

    Gupta, Sunit K.; Wahi, Pankaj

    2018-01-01

    We present an exact stability analysis of a dynamical system idealizing rotary drilling. This system comprises lumped parameter axial-torsional modes of the drill-string coupled via the cutting forces and torques. The kinematics of cutting is modeled through a functional description of the cut surface which evolves as per a partial differential equation (PDE). Linearization of this model is straightforward as opposed to the traditional state-dependent delay (SDDE) model and both the approaches result in the same characteristic equation. A systematic study on the key system parameters influencing the stability characteristics reveals that torsional damping is very critical and stable drilling is, in general, not possible in its absence. The stable regime increases as the natural frequency of the axial mode approaches that of the torsional mode and a 1:1 internal resonance leads to a significant improvement in the system stability. Hence, from a practical point of view, a drill-string with 1:1 internal resonance is desirable to avoid vibrations during rotary drilling. For the non-resonant case, axial damping reduces the stable range of operating parameters while for the resonant case, an optimum value of axial damping (equal to the torsional damping) results in the largest stable regime. Interestingly, the resonant (tuned) system has a significant parameter regime corresponding to stable operation even in the absence of damping.

  8. Renormalized Two-Fluid Hydrodynamics of Cosmic-Ray--modified Shocks

    NASA Astrophysics Data System (ADS)

    Malkov, M. A.; Voelk, H. J.

    1996-12-01

    A simple two-fluid model of diffusive shock acceleration, introduced by Axford, Leer, & Skadron and Drury & Völk, is revisited. This theory became a chief instrument in the studies of shock modification due to particle acceleration. Unfortunately its most intriguing steady state prediction about a significant enhancement of the shock compression and a corresponding increase of the cosmic-ray production violates assumptions which are critical for the derivation of this theory. In particular, for strong shocks the spectral flattening makes a cutoff-independent definition of pressure and energy density impossible and therefore causes an additional closure problem. Confining ourselves for simplicity to the case of plane shocks, assuming reacceleration of a preexisting cosmic-ray population, we argue that also under these circumstances the kinetic solution has a rather simple form. It can be characterized by only a few parameters, in the simplest case by the slope and the magnitude of the momentum distribution at the upper momentum cutoff. We relate these parameters to standard hydrodynamic quantities like the overall shock compression ratio and the downstream cosmic-ray pressure. The two-fluid theory produced in this way has the traditional form but renormalized closure parameters. By solving the renormalized Rankine-Hugoniot equations, we show that for the efficient stationary solution, most significant for cosmic-ray acceleration, the renormalization is needed in the whole parameter range of astrophysical interest.

  9. A Gaussian Approximation Approach for Value of Information Analysis.

    PubMed

    Jalal, Hawre; Alarid-Escudero, Fernando

    2018-02-01

    Most decisions are associated with uncertainty. Value of information (VOI) analysis quantifies the opportunity loss associated with choosing a suboptimal intervention based on current imperfect information. VOI can inform the value of collecting additional information, resource allocation, research prioritization, and future research designs. However, in practice, VOI remains underused due to many conceptual and computational challenges associated with its application. Expected value of sample information (EVSI) is rooted in Bayesian statistical decision theory and measures the value of information from a finite sample. The past few years have witnessed a dramatic growth in computationally efficient methods to calculate EVSI, including metamodeling. However, little research has been done to simplify the experimental data collection step inherent to all EVSI computations, especially for correlated model parameters. This article proposes a general Gaussian approximation (GA) of the traditional Bayesian updating approach based on the original work by Raiffa and Schlaifer to compute EVSI. The proposed approach uses a single probabilistic sensitivity analysis (PSA) data set and involves 2 steps: 1) a linear metamodel step to compute the EVSI on the preposterior distributions and 2) a GA step to compute the preposterior distribution of the parameters of interest. The proposed approach is efficient and can be applied for a wide range of data collection designs involving multiple non-Gaussian parameters and unbalanced study designs. Our approach is particularly useful when the parameters of an economic evaluation are correlated or interact.

  10. Imaging the effect of hemoglobin on properties of RBCs using common-path digital holographic microscope

    NASA Astrophysics Data System (ADS)

    Joglekar, M.; Shah, H.; Trivedi, V.; Mahajan, S.; Chhaniwal, V.; Leitgeb, R.; Javidi, B.; Anand, A.

    2017-07-01

    Adequate supply of oxygen to the body is the most essential requirement. In vertebrate species this function is performed by Hemoglobin contained in red blood cells. The mass concentration of the Hb determines the oxygen carrying capacity of the blood. Thus it becomes necessary to determine its concentration in the blood, which helps in monitoring the health of a person. If the amount of Hb crosses certain range, then it is considered critical. As the Hb constitutes upto 96% of red blood cells dry content, it would be interesting to examine various physical and mechanical parameters of RBCs which depends upon its concentration. Various diseases bring about significant variation in the amount of hemoglobin which may alter certain parameters of the RBC such as surface area, volume, membrane fluctuation etc. The study of the variations of these parameters may be helpful in determining Hb content which will reflect the state of health of a human body leading to disease diagnosis. Any increase or decrease in the amount of Hb will change the density and hence the optical thickness of the RBCs, which affects the cell membrane and thereby changing its mechanical and physical properties. Here we describe the use of lateral shearing digital holographic microscope for quantifying the cell parameters for studying the change in biophysical properties of cells due to variation in hemoglobin concentration.

  11. Activity monitoring reflects cardiovascular and metabolic variations in COPD patients across GOLD stages II to IV.

    PubMed

    Kortianou, E A; Louvaris, Z; Vasilopoulou, M; Nasis, I; Kaltsakas, G; Koulouris, N G; Vogiatzis, I

    2013-12-01

    We investigated whether activity monitoring reliably reflects variations in oxygen transport and utilization during walking in COPD patients. Forty-two patients (14 in each GOLD stage II, III and IV) performed an incremental treadmill protocol to the limit of tolerance. Breath-by-breath gas exchange, central hemodynamic variables and activity monitoring were simultaneously recorded. Physiological variables and accelerometer outputs rose linearly with walking speeds. Strong correlations (r[interquartile range, IQR]) were found between treadmill walking intensity (WI: range 0.8-2.0 ms(-2)) and oxygen consumption (0.95 [IQR 0.87-0.97]), (range 7.6-15.5 ml kg(-1)min(-1)); minute ventilation (0.95 [IQR 0.86-0.98]), (range 20-37 l min(-1)); cardiac output (0.89 [IQR 0.73-0.94]), (range 6.8-11.5 l min(-1)) and arteriovenous oxygen concentration difference (0.84 [IQR 0.76-0.90]), (range 7.7-12.1 ml O2100 ml(-1)). Correlations between WI and gas exchange or central hemodynamic parameters were not different across GOLD stages. In conclusion, central hemodynamic, respiratory and muscle metabolic variations during incremental treadmill exercise are tightly associated to changes in walking intensity as recorded by accelerometry across GOLD stages II to IV. Interestingly, the magnitude of these associations is not different across GOLD stages. Copyright © 2013 Elsevier B.V. All rights reserved.

  12. SUITABILITY OF USING IN VITRO AND COMPUTATIONALLY ESTIMATED PARAMETERS IN SIMPLIFIED PHARMACOKINETIC MODELS

    EPA Science Inventory

    A challenge in PBPK model development is estimating the parameters for absorption, distribution, metabolism, and excretion of the parent compound and metabolites of interest. One approach to reduce the number of parameters has been to simplify pharmacokinetic models by lumping p...

  13. Accelerated Brain DCE-MRI Using Iterative Reconstruction With Total Generalized Variation Penalty for Quantitative Pharmacokinetic Analysis: A Feasibility Study.

    PubMed

    Wang, Chunhao; Yin, Fang-Fang; Kirkpatrick, John P; Chang, Zheng

    2017-08-01

    To investigate the feasibility of using undersampled k-space data and an iterative image reconstruction method with total generalized variation penalty in the quantitative pharmacokinetic analysis for clinical brain dynamic contrast-enhanced magnetic resonance imaging. Eight brain dynamic contrast-enhanced magnetic resonance imaging scans were retrospectively studied. Two k-space sparse sampling strategies were designed to achieve a simulated image acquisition acceleration factor of 4. They are (1) a golden ratio-optimized 32-ray radial sampling profile and (2) a Cartesian-based random sampling profile with spatiotemporal-regularized sampling density constraints. The undersampled data were reconstructed to yield images using the investigated reconstruction technique. In quantitative pharmacokinetic analysis on a voxel-by-voxel basis, the rate constant K trans in the extended Tofts model and blood flow F B and blood volume V B from the 2-compartment exchange model were analyzed. Finally, the quantitative pharmacokinetic parameters calculated from the undersampled data were compared with the corresponding calculated values from the fully sampled data. To quantify each parameter's accuracy calculated using the undersampled data, error in volume mean, total relative error, and cross-correlation were calculated. The pharmacokinetic parameter maps generated from the undersampled data appeared comparable to the ones generated from the original full sampling data. Within the region of interest, most derived error in volume mean values in the region of interest was about 5% or lower, and the average error in volume mean of all parameter maps generated through either sampling strategy was about 3.54%. The average total relative error value of all parameter maps in region of interest was about 0.115, and the average cross-correlation of all parameter maps in region of interest was about 0.962. All investigated pharmacokinetic parameters had no significant differences between the result from original data and the reduced sampling data. With sparsely sampled k-space data in simulation of accelerated acquisition by a factor of 4, the investigated dynamic contrast-enhanced magnetic resonance imaging pharmacokinetic parameters can accurately estimate the total generalized variation-based iterative image reconstruction method for reliable clinical application.

  14. Dissolution of Uranium(IV) Oxide in Solutions of Ammonium Carbonate and Hydrogen Peroxide

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, Steven C.; Peper, Shane M.; Douglas, Matthew

    2009-09-12

    Understanding the dissolution characteristics of uranium oxides is of fundamental scientific interest. Bench scale experiments were conducted to determine the optimal dissolution parameters of uranium(IV) oxide (UO2) powder in solutions of ammonium carbonate [(NH4)2CO3] and hydrogen peroxide (H2O2). Experimental parameters included variable peroxide and carbonate concentrations, and temperature. Results indicate the dissolution rate of UO2 in 1 M (NH4)2CO3 increases linearly with peroxide concentration ranging from 0.05 – 2 M (1:1 to 40:1 mol ratio H2O2:U), with no apparent maximum rate reached under the limited conditions used in our study. Temperature ranging studies show the dissolution rate of UO2 inmore » 1 M (NH4)2CO3 and 0.1 M H2O2 (2:1 mol ratio H2O2:U) increases linearly from 15 °C to 60 °C, again with no apparent maximum rate reached. Dissolution of UO2 in solutions with constant [H2O2] and [(NH4)2CO3] ranging from 0.5 to 2 M showed no difference in rate; however dissolution was significantly reduced in 0.05 M (NH4)2CO3 solution. The results of this study demonstrate the influence of [H2O2], [(NH4)2CO3], and temperature on the dissolution of UO2 in peroxide-containing (NH4)2CO3 solutions. Future studies are planned to elucidate the solution and solid state complexes in these systems.« less

  15. Evaluating Uncertainty of Runoff Simulation using SWAT model of the Feilaixia Watershed in China Based on the GLUE Method

    NASA Astrophysics Data System (ADS)

    Chen, X.; Huang, G.

    2017-12-01

    In recent years, distributed hydrological models have been widely used in storm water management, water resources protection and so on. Therefore, how to evaluate the uncertainty of the model reasonably and efficiently becomes a hot topic today. In this paper, the soil and water assessment tool (SWAT) model is constructed for the study area of China's Feilaixia watershed, and the uncertainty of the runoff simulation is analyzed by GLUE method deeply. Taking the initial parameter range of GLUE method as the research core, the influence of different initial parameter ranges on model uncertainty is studied. In this paper, two sets of parameter ranges are chosen as the object of study, the first one (range 1) is recommended by SWAT-CUP and the second one (range 2) is calibrated by SUFI-2. The results showed that under the same number of simulations (10,000 times), the overall uncertainty obtained by the range 2 is less than the range 1. Specifically, the "behavioral" parameter sets for the range 2 is 10000 and for the range 1 is 4448. In the calibration and the validation, the ratio of P-factor to R-factor for range 1 is 1.387 and 1.391, and for range 2 is 1.405 and 1.462 respectively. In addition, the simulation result of range 2 is better with the NS and R2 slightly higher than range 1. Therefore, it can be concluded that using the parameter range calibrated by SUFI-2 as the initial parameter range for the GLUE is a way to effectively capture and evaluate the simulation uncertainty.

  16. Effectiveness of the 3D Monitor System for Medical Education During Neurosurgical Operation.

    PubMed

    Wanibuchi, Masahiko; Komatsu, Katsuya; Akiyama, Yukinori; Mikami, Takeshi; Mikuni, Nobuhiro

    2018-01-01

    Three-dimensional (3D) graphics are used in the medical field, especially during surgery. Although 3D monitoring is useful for medical education, its effectiveness needs to be objectively evaluated. The aim of this study was to investigate the efficacy of 3D monitoring in the surgical education of medical students. A questionnaire on high-definition 3D monitoring was given to fifth-year medical students in a 6-year program. Sixty-four students wore polarized glasses and observed a microsurgical operation through a 3D monitor. The questionnaire contained questions on stereopsis, neurosurgical interest, visual impact, comprehension of surgical anatomy and procedures, optical sharpness, active learning enhancement, and eye exhaustion. These parameters were evaluated on a 5-point scale that spanned negative and positive scores. The average score of each parameter ranged from 3.13 to 3.78, except for eye exhaustion, which was 0.88. The items for which the students reported positive perceptions (scores of 4 or 5) were stereopsis (67.2% of students), neurosurgical interest (62.5%), visual impact and optical sharpness (60.9% for both), active learning enhancement (57.8%), and comprehension of surgical anatomy (50.0%) and procedures (42.2%). By contrast, only eye exhaustion was evaluated negatively (26.6%). The use of 3D monitoring systems in medical education offers the advantage of stereopsis and contributes to surgical training. However, improvements are required to decrease eye exhaustion. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Quantity and distribution of plaque in orthodontic patients treated with molar bands.

    PubMed

    Erbe, Christina; Hornikel, Sandra; Schmidtmann, Irene; Wehrbein, Heiner

    2011-03-01

    The placement of orthodontic bands usually increases plaque accumulation due to numerous mechanical retention sites. The purpose of this investigation was to evaluate the amount and distribution pattern of biofilm in the oral (palatal and lingual) and interproximal regions surrounding orthodontic bands. We evaluated the formation of biofilm on 32 orthodontic bands which had been placed intraorally for 6-37 months. Two parameters were measured: the percentage of surface covered by biofilm (quantity) and the biofilm distribution pattern of accumulation. We measured these two parameters in four regions of interest: the mesial and distal interproximal regions, as well as the mesial and distal regions of the oral attachment. The quantity of biofilm formation was similar in all four regions of interest, ranging from 13.3% to 16.8%. In contrast to biofilm quantity, distribution patterns differed in the four regions. In the mesial and distal interproximal regions it appeared as extensive insular areas in 87.5% and 71.9%, respectively, whereas it appeared more often supragingival and linear in nature in regions adjacent to the oral attachment, i.e. in 65.6% and 68.8%, respectively. Our results indicate that firstly, oral hygiene in the palatal and lingual regions of orthodontic bands seems as difficult as it is in the interproximal areas, thus requiring thorough hygiene in both areas. Secondly, orthodontic patients with a history of periodontal disease require special attention regarding the use of orthodontic bands.

  18. Motor unit recruitment by size does not provide functional advantages for motor performance

    PubMed Central

    Dideriksen, Jakob L; Farina, Dario

    2013-01-01

    It is commonly assumed that the orderly recruitment of motor units by size provides a functional advantage for the performance of movements compared with a random recruitment order. On the other hand, the excitability of a motor neuron depends on its size and this is intrinsically linked to its innervation number. A range of innervation numbers among motor neurons corresponds to a range of sizes and thus to a range of excitabilities ordered by size. Therefore, if the excitation drive is similar among motor neurons, the recruitment by size is inevitably due to the intrinsic properties of motor neurons and may not have arisen to meet functional demands. In this view, we tested the assumption that orderly recruitment is necessarily beneficial by determining if this type of recruitment produces optimal motor output. Using evolutionary algorithms and without any a priori assumptions, the parameters of neuromuscular models were optimized with respect to several criteria for motor performance. Interestingly, the optimized model parameters matched well known neuromuscular properties, but none of the optimization criteria determined a consistent recruitment order by size unless this was imposed by an association between motor neuron size and excitability. Further, when the association between size and excitability was imposed, the resultant model of recruitment did not improve the motor performance with respect to the absence of orderly recruitment. A consistent observation was that optimal solutions for a variety of criteria of motor performance always required a broad range of innervation numbers in the population of motor neurons, skewed towards the small values. These results indicate that orderly recruitment of motor units in itself does not provide substantial functional advantages for motor control. Rather, the reason for its near-universal presence in human movements is that motor functions are optimized by a broad range of innervation numbers. PMID:24144879

  19. Motor unit recruitment by size does not provide functional advantages for motor performance.

    PubMed

    Dideriksen, Jakob L; Farina, Dario

    2013-12-15

    It is commonly assumed that the orderly recruitment of motor units by size provides a functional advantage for the performance of movements compared with a random recruitment order. On the other hand, the excitability of a motor neuron depends on its size and this is intrinsically linked to its innervation number. A range of innervation numbers among motor neurons corresponds to a range of sizes and thus to a range of excitabilities ordered by size. Therefore, if the excitation drive is similar among motor neurons, the recruitment by size is inevitably due to the intrinsic properties of motor neurons and may not have arisen to meet functional demands. In this view, we tested the assumption that orderly recruitment is necessarily beneficial by determining if this type of recruitment produces optimal motor output. Using evolutionary algorithms and without any a priori assumptions, the parameters of neuromuscular models were optimized with respect to several criteria for motor performance. Interestingly, the optimized model parameters matched well known neuromuscular properties, but none of the optimization criteria determined a consistent recruitment order by size unless this was imposed by an association between motor neuron size and excitability. Further, when the association between size and excitability was imposed, the resultant model of recruitment did not improve the motor performance with respect to the absence of orderly recruitment. A consistent observation was that optimal solutions for a variety of criteria of motor performance always required a broad range of innervation numbers in the population of motor neurons, skewed towards the small values. These results indicate that orderly recruitment of motor units in itself does not provide substantial functional advantages for motor control. Rather, the reason for its near-universal presence in human movements is that motor functions are optimized by a broad range of innervation numbers.

  20. Collision cross sections and diffusion parameters for H and D in atomic oxygen. [in upper earth and Venus atmospheres

    NASA Technical Reports Server (NTRS)

    Hodges, R. R., Jr.

    1993-01-01

    Modeling the behavior of H and D in planetary exospheres requires detailed knowledge of the differential scattering cross sections for all of the important neutral-neutral and ion-neutral collision processes affecting these species over their entire ranges of interaction energies. In the upper atmospheres of Earth, Venus, and other planets as well, the interactions of H and D with atomic oxygen determine the rates of diffusion of escaping hydrogen isotopes through the thermosphere, the velocity distributions of exospheric atoms that encounter the upper thermosphere, the lifetimes of exospheric orbiters with periapsides near the exobase, and the transfer of momentum in collisions with hot O. The nature of H-O and D-O collisions and the derivation of a data base consisting of phase shifts and the differential, total, and momentum transfer cross sections for these interactions in the energy range 0.001 - 10 eV are discussed. Coefficients of mutual diffusion and thermal diffusion factors are calculated for temperatures of planetary interest.

  1. Large-eddy simulation of the passage of a shock wave through homogeneous turbulence

    NASA Astrophysics Data System (ADS)

    Braun, N. O.; Pullin, D. I.; Meiron, D. I.

    2017-11-01

    The passage of a nominally plane shockwave through homogeneous, compressible turbulence is a canonical problem representative of flows seen in supernovae, supersonic combustion engines, and inertial confinement fusion. The interaction of isotropic turbulence with a stationary normal shockwave is considered at inertial range Taylor Reynolds numbers, Reλ = 100 - 2500 , using Large Eddy Simulation (LES). The unresolved, subgrid terms are approximated by the stretched-vortex model (Kosovic et al., 2002), which allows self-consistent reconstruction of the subgrid contributions to the turbulent statistics of interest. The mesh is adaptively refined in the vicinity of the shock to resolve small amplitude shock oscillations, and the implications of mesh refinement on the subgrid modeling are considered. Simulations are performed at a range of shock Mach numbers, Ms = 1.2 - 3.0 , and turbulent Mach numbers, Mt = 0.06 - 0.18 , to explore the parameter space of the interaction at high Reynolds number. The LES shows reasonable agreement with linear analysis and lower Reynolds number direct numerical simulations. LANL Subcontract 305963.

  2. ABCluster: the artificial bee colony algorithm for cluster global optimization.

    PubMed

    Zhang, Jun; Dolg, Michael

    2015-10-07

    Global optimization of cluster geometries is of fundamental importance in chemistry and an interesting problem in applied mathematics. In this work, we introduce a relatively new swarm intelligence algorithm, i.e. the artificial bee colony (ABC) algorithm proposed in 2005, to this field. It is inspired by the foraging behavior of a bee colony, and only three parameters are needed to control it. We applied it to several potential functions of quite different nature, i.e., the Coulomb-Born-Mayer, Lennard-Jones, Morse, Z and Gupta potentials. The benchmarks reveal that for long-ranged potentials the ABC algorithm is very efficient in locating the global minimum, while for short-ranged ones it is sometimes trapped into a local minimum funnel on a potential energy surface of large clusters. We have released an efficient, user-friendly, and free program "ABCluster" to realize the ABC algorithm. It is a black-box program for non-experts as well as experts and might become a useful tool for chemists to study clusters.

  3. Aerodynamic resistance reduction of electric and hybrid vehicles

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The generation of an EHV aerodynamic data base was initiated by conducting full-scale wind tunnel tests on 16 vehicles. Zero-yaw drag coefficients ranged from a high of 0.58 for a boxey delivery van and an open roadster to a low of about 0.34 for a current 4-passenger prototype automobile which was designed with aerodynamics as an integrated parameter. Characteristic effects of aspect ratio or fineness ratio which might appear if electric vehicle shape proportions were to vary significantly from current automobiles were identified. Some preliminary results indicate a 5 to 10% variation in drag over the range of interest. Effective drag coefficient wind-weighting factors over J227a driving cycles in the presence of annual mean wind fields were identified. Such coefficients, when properly weighted, were found to be from 5 to 65% greater than the zero-yaw drag coefficient in the cases presented. A vehicle aerodynamics bibliography of over 160 entries, in six general categories is included.

  4. Winglet effectiveness on low aspect ratio wings at supersonic Mach numbers

    NASA Technical Reports Server (NTRS)

    Keenan, J. A.; Kuhlman, J. M.

    1991-01-01

    A computational study has been conducted on two wings of aspect ratios 1.244 and 1.865, each having 65-deg leading edge sweep angles, to determine the effects of nonplanar winglets at supersonic Mach numbers. A design Mach number of 1.62 was selected. The winglets studied were parametrically varied in alignment, length, sweep, camber, and thickness to determine the effects of winglet geometry on predicted performance. For the computational analysis, an existing Euler code that employed a marching technique was used. The results indicated that the possibility existed for wing-winglet geometries to equal the performance of wing-alone bodies in supersonic flows with both bodies having the same semispan length. The performance parameters of main interest were the lift-to-pressure drag ratio and the pressure drag coefficient as functions of lift coefficient. The lift coefficient range for this study was from -0.20 to 0.70 with emphasis on the range of 0.10 to 0.22.

  5. Isothermal decay studies of intermediate energy levels in quartz.

    PubMed

    Veronese, I; Giussani, A; Göksu, H Y; Martini, M

    2004-05-01

    The recent interest in the thermoluminescence of quartz extracted from unfired building materials, such as mortar and concrete for dose reconstruction applications, led to the requirement of an accurate determination of the lifetime of the intermediate glow peaks in this mineral. The prediction of the lifetimes of these peaks is helpful in establishing the likely time range within which retrospective measurements can be carried out. These peaks, corresponding to intermediate energy levels, occur in the glow curve in the temperature range 150-250 degrees C (heating rate 2 degrees C/s). Lifetimes of 720+/-70 days and 580+/-70 years (at a temperature of 15 degrees C) were derived for the two main peaks placed in the glow curve at approximately 150 degrees C and 200 degrees C, respectively, using the isothermal decay technique. These results as well as the estimated values of the trap parameters (thermal activation energy and frequency factor) have been compared with the data already available in the literature.

  6. Regional regression models of watershed suspended-sediment discharge for the eastern United States

    NASA Astrophysics Data System (ADS)

    Roman, David C.; Vogel, Richard M.; Schwarz, Gregory E.

    2012-11-01

    SummaryEstimates of mean annual watershed sediment discharge, derived from long-term measurements of suspended-sediment concentration and streamflow, often are not available at locations of interest. The goal of this study was to develop multivariate regression models to enable prediction of mean annual suspended-sediment discharge from available basin characteristics useful for most ungaged river locations in the eastern United States. The models are based on long-term mean sediment discharge estimates and explanatory variables obtained from a combined dataset of 1201 US Geological Survey (USGS) stations derived from a SPAtially Referenced Regression on Watershed attributes (SPARROW) study and the Geospatial Attributes of Gages for Evaluating Streamflow (GAGES) database. The resulting regional regression models summarized for major US water resources regions 1-8, exhibited prediction R2 values ranging from 76.9% to 92.7% and corresponding average model prediction errors ranging from 56.5% to 124.3%. Results from cross-validation experiments suggest that a majority of the models will perform similarly to calibration runs. The 36-parameter regional regression models also outperformed a 16-parameter national SPARROW model of suspended-sediment discharge and indicate that mean annual sediment loads in the eastern United States generally correlates with a combination of basin area, land use patterns, seasonal precipitation, soil composition, hydrologic modification, and to a lesser extent, topography.

  7. Regional regression models of watershed suspended-sediment discharge for the eastern United States

    USGS Publications Warehouse

    Roman, David C.; Vogel, Richard M.; Schwarz, Gregory E.

    2012-01-01

    Estimates of mean annual watershed sediment discharge, derived from long-term measurements of suspended-sediment concentration and streamflow, often are not available at locations of interest. The goal of this study was to develop multivariate regression models to enable prediction of mean annual suspended-sediment discharge from available basin characteristics useful for most ungaged river locations in the eastern United States. The models are based on long-term mean sediment discharge estimates and explanatory variables obtained from a combined dataset of 1201 US Geological Survey (USGS) stations derived from a SPAtially Referenced Regression on Watershed attributes (SPARROW) study and the Geospatial Attributes of Gages for Evaluating Streamflow (GAGES) database. The resulting regional regression models summarized for major US water resources regions 1–8, exhibited prediction R2 values ranging from 76.9% to 92.7% and corresponding average model prediction errors ranging from 56.5% to 124.3%. Results from cross-validation experiments suggest that a majority of the models will perform similarly to calibration runs. The 36-parameter regional regression models also outperformed a 16-parameter national SPARROW model of suspended-sediment discharge and indicate that mean annual sediment loads in the eastern United States generally correlates with a combination of basin area, land use patterns, seasonal precipitation, soil composition, hydrologic modification, and to a lesser extent, topography.

  8. Modeling the Effect of Modified Atmospheres on Conidial Germination of Fungi from Dairy Foods

    PubMed Central

    Nguyen Van Long, Nicolas; Vasseur, Valérie; Couvert, Olivier; Coroller, Louis; Burlot, Marion; Rigalma, Karim; Mounier, Jérôme

    2017-01-01

    Modified atmosphere packaging (MAP) is commonly applied to extend food shelf-life. Despite growth of a wide variety of fungal contaminants has been previously studied in relation to modified-atmospheres, few studies aimed at quantifying the effects of dioxygen (O2) and carbon dioxide (CO2) partial pressures on conidial germination in solid agar medium. In the present study, an original culture method was developed, allowing microscopic monitoring of conidial germination under modified-atmospheres in static conditions. An asymmetric model was utilized to describe germination kinetics of Paecilomyces niveus, Mucor lanceolatus, Penicillium brevicompactum, Penicillium expansum, and Penicillium roquefoti, using two main parameters, i.e., median germination time (τ) and maximum germination percentage (Pmax). These two parameters were subsequently modeled as a function of O2 partial pressure ranging from 0 to 21% and CO2 partial pressure ranging from 0.03 to 70% (8 tested levels for both O2 and CO2). Modified atmospheres with residual O2 or CO2 partial pressures below 1% and up to 70%, respectively, were not sufficient to totally inhibit conidial germination,. However, O2 levels < 1% or CO2 levels > 20% significantly increased τ and/or reduced Pmax, depending on the fungal species. Overall, the present method and results are of interest for predictive mycology applied to fungal spoilage of MAP food products. PMID:29163403

  9. Retention and Migration of Chlorpyrifos in Aquatic Sediments and Soils

    NASA Astrophysics Data System (ADS)

    Gebremariam, S. Y.; Beutel, M.; Yonge, D.; Flury, M.; Harsh, J. B.

    2010-12-01

    The accurate description of the fate and transport of potentially toxic agricultural pesticides in sediments and soils is of great interest to environmental scientists and regulators. Of particular concern is the widely documented detection of agricultural pesticides and their byproducts in drinking water wells. This presentation discusses results of a study of the fate and transport of chlorpyrifos, a strongly hydrophobic organophosphate-pesticide, in sediments and soils collected from a range of aquatic environments. Using radio-labeled chlorpyrifos, this study is unique in its comprehensive nature and focus on aquatic sediments, for which studies involving pesticide fate and transport are limited. Study components include: (1) batch equilibrium experiments to evaluate sorption/desorption parameters; (2) kinetic and non-equilibrium sorption experiments using miniaturized flow-cells; (3) column experiments to understand patterns of pesticide break through; and (4) numerical modeling of chlorpyrifos transport through aquatic sediments and soils. Initial results show that chlorpyrifos sorption, when corrected for reversible sorption to container walls, exhibited two component sorption, a large irreversible fraction and a smaller reversible fraction that can act as a secondary source. In addition, of a wide range of soil parameters measured, organic carbon content exhibited the highest correlation with chlorpyrifos retention in cranberry field soils. Simulation models developed in this study, which account for hysteretic and nonlinear sorption, will help to better predict the fate of chlorpyrifos and other hydrophobic chemicals in sediments and soils.

  10. Method and apparatus for transfer function simulator for testing complex systems

    NASA Technical Reports Server (NTRS)

    Kavaya, M. J. (Inventor)

    1985-01-01

    A method and apparatus for testing the operation of a complex stabilization circuit in a closed loop system is presented. The method is comprised of a programmed analog or digital computing system for implementing the transfer function of a load thereby providing a predictable load. The digital computing system employs a table stored in a microprocessor in which precomputed values of the load transfer function are stored for values of input signal from the stabilization circuit over the range of interest. This technique may be used not only for isolating faults in the stabilization circuit, but also for analyzing a fault in a faulty load by so varying parameters of the computing system as to simulate operation of the actual load with the fault.

  11. Quantitative fluorescence and elastic scattering tissue polarimetry using an Eigenvalue calibrated spectroscopic Mueller matrix system.

    PubMed

    Soni, Jalpa; Purwar, Harsh; Lakhotia, Harshit; Chandel, Shubham; Banerjee, Chitram; Kumar, Uday; Ghosh, Nirmalya

    2013-07-01

    A novel spectroscopic Mueller matrix system has been developed and explored for both fluorescence and elastic scattering polarimetric measurements from biological tissues. The 4 × 4 Mueller matrix measurement strategy is based on sixteen spectrally resolved (λ = 400 - 800 nm) measurements performed by sequentially generating and analyzing four elliptical polarization states. Eigenvalue calibration of the system ensured high accuracy of Mueller matrix measurement over a broad wavelength range, either for forward or backscattering geometry. The system was explored for quantitative fluorescence and elastic scattering spectroscopic polarimetric studies on normal and precancerous tissue sections from human uterine cervix. The fluorescence spectroscopic Mueller matrices yielded an interesting diattenuation parameter, exhibiting differences between normal and precancerous tissues.

  12. Consideration of probability of bacterial growth for Jovian planets and their satellites

    NASA Technical Reports Server (NTRS)

    Taylor, D. M.; Berkman, R. M.; Divine, N.

    1974-01-01

    Environmental parameters affecting growth of bacteria are compared with current atmospheric models for Jupiter and Saturn, and with the available physical data for their satellites. Different zones of relative probability of growth are identified for Jupiter and Saturn. Of the more than two dozen satellites, only the largest (Io, Europa, Ganymede, Callisto, and Titan) are found to be interesting biologically. Titan's atmosphere may produce a substantial greenhouse effect providing increased surface temperatures. Models predicting a dense atmosphere are compatible with microbial growth for a range of pressures at Titan's surface. For Titan's surface the probability of growth would be enhanced if: (1) the surface is entirely or partially liquid; (2) volcanism is present; or (3) access to internal heat sources is significant.

  13. Born iterative reconstruction using perturbed-phase field estimates.

    PubMed

    Astheimer, Jeffrey P; Waag, Robert C

    2008-10-01

    A method of image reconstruction from scattering measurements for use in ultrasonic imaging is presented. The method employs distorted-wave Born iteration but does not require using a forward-problem solver or solving large systems of equations. These calculations are avoided by limiting intermediate estimates of medium variations to smooth functions in which the propagated fields can be approximated by phase perturbations derived from variations in a geometric path along rays. The reconstruction itself is formed by a modification of the filtered-backpropagation formula that includes correction terms to account for propagation through an estimated background. Numerical studies that validate the method for parameter ranges of interest in medical applications are presented. The efficiency of this method offers the possibility of real-time imaging from scattering measurements.

  14. Mining the Internet for Intro Physics Data: Sports Equipment

    NASA Astrophysics Data System (ADS)

    Pawl, Andrew; Pritchard, David; Barrantes, Analia

    2008-10-01

    Problems using typical numbers for sports equipment parameters such as: ``A 0.285 kg tennis racket strikes a 0.058 kg tennis ball'' are common in introductory physics. The numbers are usually reasonable, but often do not tell the whole story. Continuing with the example above, tennis ball masses are tightly constrained by the International Tennis Federation (ITF) to range between 56.0 g and 59.4 g, but the rules do not restrict the mass of tennis rackets. Instead, physics plays an important role in fixing the preferred tennis racket mass. In this presentation, we give an example of how internet research using the readily available commercial websites of sports equipment manufacturers can enrich introductory physics problems and spark interesting follow-up questions.

  15. Generation of Requirements for Simulant Measurements. Revised, May 30, 2010

    NASA Technical Reports Server (NTRS)

    Rickman, Doug; Edmunson, Jennifer

    2010-01-01

    This document provides a formal, logical explanation of the parameters selected for the Figure of Merit algorithm used to evaluate lunar regolith simulant. The objectives, requirements, assumptions and analysis behind the parameters is provided. From NASA's objectives for lunar simulants a requirement is derived to verify and validate simulant performance versus lunar regolith. This requirement leads to a specification that comparative measurements be taken the same way on the regolith and the simulant. In turn this leads to a set of 9 criteria with which to evaluate comparative measurement. Many of the potential measurements of interest are not defensible under these criteria, for example many geotechnical properties of interest were not explicitly measured during Apollo and they can only be measured in situ on the Moon. A 2005 workshop identified 32 properties of major interest to users (Sibille Carpenter Schlagheck, and French, 2006). Virtually all of the properties are tightly constrained, though not predictable, if just four parameters are controlled. Three: composition, size and shape, are recognized as being definable at the particle level. The fourth, density, is a bulk property. In recent work a fifth parameter has been identified, which will need to be added to future releases of the Figure of Merit: spectroscopy.

  16. Bayesian analysis of caustic-crossing microlensing events

    NASA Astrophysics Data System (ADS)

    Cassan, A.; Horne, K.; Kains, N.; Tsapras, Y.; Browne, P.

    2010-06-01

    Aims: Caustic-crossing binary-lens microlensing events are important anomalous events because they are capable of detecting an extrasolar planet companion orbiting the lens star. Fast and robust modelling methods are thus of prime interest in helping to decide whether a planet is detected by an event. Cassan introduced a new set of parameters to model binary-lens events, which are closely related to properties of the light curve. In this work, we explain how Bayesian priors can be added to this framework, and investigate on interesting options. Methods: We develop a mathematical formulation that allows us to compute analytically the priors on the new parameters, given some previous knowledge about other physical quantities. We explicitly compute the priors for a number of interesting cases, and show how this can be implemented in a fully Bayesian, Markov chain Monte Carlo algorithm. Results: Using Bayesian priors can accelerate microlens fitting codes by reducing the time spent considering physically implausible models, and helps us to discriminate between alternative models based on the physical plausibility of their parameters.

  17. Combined experiment Phase 2 data characterization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, M.S.; Shipley, D.E.; Young, T.S.

    1995-11-01

    The National Renewable Energy Laboratory`s ``Combined Experiment`` has yielded a large quantity of experimental data on the operation of a downwind horizontal axis wind turbine under field conditions. To fully utilize this valuable resource and identify particular episodes of interest, a number of databases were created that characterize individual data events and rotational cycles over a wide range of parameters. Each of the 59 five-minute data episodes collected during Phase 11 of the Combined Experiment have been characterized by the mean, minimum, maximum, and standard deviation of all data channels, except the blade surface pressures. Inflow condition, aerodynamic force coefficient,more » and minimum leading edge pressure coefficient databases have also been established, characterizing each of nearly 21,000 blade rotational cycles. In addition, a number of tools have been developed for searching these databases for particular episodes of interest. Due to their extensive size, only a portion of the episode characterization databases are included in an appendix, and examples of the cycle characterization databases are given. The search tools are discussed and the FORTRAN or C code for each is included in appendices.« less

  18. A unified genetic association test robust to latent population structure for a count phenotype.

    PubMed

    Song, Minsun

    2018-06-04

    Confounding caused by latent population structure in genome-wide association studies has been a big concern despite the success of genome-wide association studies at identifying genetic variants associated with complex diseases. In particular, because of the growing interest in association mapping using count phenotype data, it would be interesting to develop a testing framework for genetic associations that is immune to population structure when phenotype data consist of count measurements. Here, I propose a solution for testing associations between single nucleotide polymorphisms and a count phenotype in the presence of an arbitrary population structure. I consider a classical range of models for count phenotype data. Under these models, a unified test for genetic associations that protects against confounding was derived. An algorithm was developed to efficiently estimate the parameters that are required to fit the proposed model. I illustrate the proposed approach using simulation studies and an empirical study. Both simulated and real-data examples suggest that the proposed method successfully corrects population structure. Copyright © 2018 John Wiley & Sons, Ltd.

  19. Career Self-Efficacy Expectations and Perceived Range of Career Options in Community College Students.

    ERIC Educational Resources Information Center

    Rotberg, Heidi L.; And Others

    1987-01-01

    Explored the relation of socioeconomic status (SES), race, gender, career self-efficacy, career interests, and sex role orientation to career-choice range in female-male and non-gender-dominated careers and career self-efficacy. Career interest and career self-efficacy expectations significantly predicted range of perceived career options. Career…

  20. A quantitative survey of gravity receptor function in mutant mouse strains.

    PubMed

    Jones, Sherri M; Johnson, Kenneth R; Yu, Heping; Erway, Lawrence C; Alagramam, Kumar N; Pollak, Natasha; Jones, Timothy A

    2005-12-01

    The purpose of this research was to identify vestibular deficits in mice using linear vestibular evoked potentials (VsEPs). VsEP thresholds, peak latencies, and peak amplitudes from 24 strains with known genetic mutations and 6 inbred background strains were analyzed and descriptive statistics generated for each strain. Response parameters from mutant homozygotes were compared with heterozygote and/or background controls and all strain averages were contrasted to normative ranges. Homozygotes of the following recessive mutations had absent VsEPs at the ages tested: Espn(je), Atp2b2dfw-2J, Spnb4qv-lnd2J, Spnb4qv-3J, Myo7ash1, Tmie(sr), Myo6sv, jc, Pcdh15av-J, Pcdh15av-2J, Pcdh15av-3J, Cdh23v-2J, Sans(js), hr, Kcne1pkr and Pou3f4del. These results suggest profound gravity receptor deficits for these homozygotes, which is consistent with the structural deficits that have been documented for many of these strains. Homozygotes of Catna2cdf, Grid2ho4J, Wnt1sw, qk, and Mbpshi strains and heterozygotes of Grid2lc had measurable VsEPs but one or more response parameters differed from the respective control group (heterozygote or background strain) or were outside normal ranges. For example, qk and Mbpshi homozygotes showed significantly prolonged latencies consistent with the abnormal myelin that has been described for these strains. Prolonged latencies may suggest deficits in neural conduction; elevated thresholds suggest reduced sensitivity, and reduced amplitudes may be suggestive for reduced neural synchrony. One mutation, Otx1jv, had all VsEP response parameters within normal limits--an expected finding because the abnormality in Otxljv is presumably restricted to the lateral semicircular canal. Interestingly, some heterozygote groups also showed abnormalities in one or more VsEP response parameters, suggesting that vestibular dysfunction, although less severe, may be present in some heterozygous animals.

  1. Does probability of occurrence relate to population dynamics?

    USGS Publications Warehouse

    Thuiller, Wilfried; Münkemüller, Tamara; Schiffers, Katja H.; Georges, Damien; Dullinger, Stefan; Eckhart, Vincent M.; Edwards, Thomas C.; Gravel, Dominique; Kunstler, Georges; Merow, Cory; Moore, Kara; Piedallu, Christian; Vissault, Steve; Zimmermann, Niklaus E.; Zurell, Damaris; Schurr, Frank M.

    2014-01-01

    Hutchinson defined species' realized niche as the set of environmental conditions in which populations can persist in the presence of competitors. In terms of demography, the realized niche corresponds to the environments where the intrinsic growth rate (r) of populations is positive. Observed species occurrences should reflect the realized niche when additional processes like dispersal and local extinction lags do not have overwhelming effects. Despite the foundational nature of these ideas, quantitative assessments of the relationship between range-wide demographic performance and occurrence probability have not been made. This assessment is needed both to improve our conceptual understanding of species' niches and ranges and to develop reliable mechanistic models of species geographic distributions that incorporate demography and species interactions.The objective of this study is to analyse how demographic parameters (intrinsic growth rate r and carrying capacity K ) and population density (N ) relate to occurrence probability (Pocc ). We hypothesized that these relationships vary with species' competitive ability. Demographic parameters, density, and occurrence probability were estimated for 108 tree species from four temperate forest inventory surveys (Québec, western USA, France and Switzerland). We used published information of shade tolerance as indicators of light competition strategy, assuming that high tolerance denotes high competitive capacity in stable forest environments.Interestingly, relationships between demographic parameters and occurrence probability did not vary substantially across degrees of shade tolerance and regions. Although they were influenced by the uncertainty in the estimation of the demographic parameters, we found that r was generally negatively correlated with Pocc, while N, and for most regions K, was generally positively correlated with Pocc. Thus, in temperate forest trees the regions of highest occurrence probability are those with high densities but slow intrinsic population growth rates. The uncertain relationships between demography and occurrence probability suggests caution when linking species distribution and demographic models.

  2. Precipitable water vapour content from ESR/SKYNET sun-sky radiometers: validation against GNSS/GPS and AERONET over three different sites in Europe

    NASA Astrophysics Data System (ADS)

    Campanelli, Monica; Mascitelli, Alessandra; Sanò, Paolo; Diémoz, Henri; Estellés, Victor; Federico, Stefano; Iannarelli, Anna Maria; Fratarcangeli, Francesca; Mazzoni, Augusto; Realini, Eugenio; Crespi, Mattia; Bock, Olivier; Martínez-Lozano, Jose A.; Dietrich, Stefano

    2018-01-01

    The estimation of the precipitable water vapour content (W) with high temporal and spatial resolution is of great interest to both meteorological and climatological studies. Several methodologies based on remote sensing techniques have been recently developed in order to obtain accurate and frequent measurements of this atmospheric parameter. Among them, the relative low cost and easy deployment of sun-sky radiometers, or sun photometers, operating in several international networks, allowed the development of automatic estimations of W from these instruments with high temporal resolution. However, the great problem of this methodology is the estimation of the sun-photometric calibration parameters. The objective of this paper is to validate a new methodology based on the hypothesis that the calibration parameters characterizing the atmospheric transmittance at 940 nm are dependent on vertical profiles of temperature, air pressure and moisture typical of each measurement site. To obtain the calibration parameters some simultaneously seasonal measurements of W, from independent sources, taken over a large range of solar zenith angle and covering a wide range of W, are needed. In this work yearly GNSS/GPS datasets were used for obtaining a table of photometric calibration constants and the methodology was applied and validated in three European ESR-SKYNET network sites, characterized by different atmospheric and climatic conditions: Rome, Valencia and Aosta. Results were validated against the GNSS/GPS and AErosol RObotic NETwork (AERONET) W estimations. In both the validations the agreement was very high, with a percentage RMSD of about 6, 13 and 8 % in the case of GPS intercomparison at Rome, Aosta and Valencia, respectively, and of 8 % in the case of AERONET comparison in Valencia. Analysing the results by W classes, the present methodology was found to clearly improve W estimation at low W content when compared against AERONET in terms of % bias, bringing the agreement with the GPS (considered the reference one) from a % bias of 5.76 to 0.52.

  3. Planes, Trains, Automobiles--and Tea Sets: Extremely Intense Interests in Very Young Children

    ERIC Educational Resources Information Center

    DeLoache, Judy S.; Simcock, Gabrielle; Macari, Suzanne

    2007-01-01

    Some normally developing young children show an intense, passionate interest in a particular category of objects or activities. The present article documents the existence of extremely intense interests that emerge very early in life and establishes some of the basic parameters of the phenomenon. Surveys and interviews with 177 parents revealed…

  4. On Markov parameters in system identification

    NASA Technical Reports Server (NTRS)

    Phan, Minh; Juang, Jer-Nan; Longman, Richard W.

    1991-01-01

    A detailed discussion of Markov parameters in system identification is given. Different forms of input-output representation of linear discrete-time systems are reviewed and discussed. Interpretation of sampled response data as Markov parameters is presented. Relations between the state-space model and particular linear difference models via the Markov parameters are formulated. A generalization of Markov parameters to observer and Kalman filter Markov parameters for system identification is explained. These extended Markov parameters play an important role in providing not only a state-space realization, but also an observer/Kalman filter for the system of interest.

  5. Histogram analysis of diffusion kurtosis imaging estimates for in vivo assessment of 2016 WHO glioma grades: A cross-sectional observational study.

    PubMed

    Hempel, Johann-Martin; Schittenhelm, Jens; Brendle, Cornelia; Bender, Benjamin; Bier, Georg; Skardelly, Marco; Tabatabai, Ghazaleh; Castaneda Vega, Salvador; Ernemann, Ulrike; Klose, Uwe

    2017-10-01

    To assess the diagnostic performance of histogram analysis of diffusion kurtosis imaging (DKI) maps for in vivo assessment of the 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 CNS WHO) integrated glioma grades. Seventy-seven patients with histopathologically-confirmed glioma who provided written informed consent were retrospectively assessed between 01/2014 and 03/2017 from a prospective trial approved by the local institutional review board. Ten histogram parameters of mean kurtosis (MK) and mean diffusivity (MD) metrics from DKI were independently assessed by two blinded physicians from a volume of interest around the entire solid tumor. One-way ANOVA was used to compare MK and MD histogram parameter values between 2016 CNS WHO-based tumor grades. Receiver operating characteristic analysis was performed on MK and MD histogram parameters for significant results. The 25th, 50th, 75th, and 90th percentiles of MK and average MK showed significant differences between IDH1/2 wild-type gliomas, IDH1/2 mutated gliomas, and oligodendrogliomas with chromosome 1p/19q loss of heterozygosity and IDH1/2 mutation (p<0.001). The 50th, 75th, and 90th percentiles showed a slightly higher diagnostic performance (area under the curve (AUC) range; 0.868-0.991) than average MK (AUC range; 0.855-0.988) in classifying glioma according to the integrated approach of 2016 CNS WHO. Histogram analysis of DKI can stratify gliomas according to the integrated approach of 2016 CNS WHO. The 50th (median), 75th , and the 90th percentiles showed the highest diagnostic performance. However, the average MK is also robust and feasible in routine clinical practice. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Implementation of smart phone video plethysmography and dependence on lighting parameters.

    PubMed

    Fletcher, Richard Ribón; Chamberlain, Daniel; Paggi, Nicholas; Deng, Xinyue

    2015-08-01

    The remote measurement of heart rate (HR) and heart rate variability (HRV) via a digital camera (video plethysmography) has emerged as an area of great interest for biomedical and health applications. While a few implementations of video plethysmography have been demonstrated on smart phones under controlled lighting conditions, it has been challenging to create a general scalable solution due to the large variability in smart phone hardware performance, software architecture, and the variable response to lighting parameters. In this context, we present a selfcontained smart phone implementation of video plethysmography for Android OS, which employs both stochastic and deterministic algorithms, and we use this to study the effect of lighting parameters (illuminance, color spectrum) on the accuracy of the remote HR measurement. Using two different phone models, we present the median HR error for five different video plethysmography algorithms under three different types of lighting (natural sunlight, compact fluorescent, and halogen incandescent) and variations in brightness. For most algorithms, we found the optimum light brightness to be in the range 1000-4000 lux and the optimum lighting types to be compact fluorescent and natural light. Moderate errors were found for most algorithms with some devices under conditions of low-brightness (<;500 lux) and highbrightness (>4000 lux). Our analysis also identified camera frame rate jitter as a major source of variability and error across different phone models, but this can be largely corrected through non-linear resampling. Based on testing with six human subjects, our real-time Android implementation successfully predicted the measured HR with a median error of -0.31 bpm, and an inter-quartile range of 2.1bpm.

  7. Weakening iliopsoas muscle in healthy adults may induce stiff knee pattern.

    PubMed

    Akalan, N Ekin; Kuchimov, Shavkat; Apti, Adnan; Temelli, Yener; Nene, Anand

    2016-12-01

    The goal of the present study was to investigate the relationship between iliopsoas muscle group weakness and related hip joint velocity reduction and stiff-knee gait (SKG) during walking in healthy individuals. A load of 5% of each individual's body weight was placed on non-dominant thigh of 15 neurologically intact, able-bodied participants (average age: 22.4 ± 0.81 years). For 33 min (135 s × 13 repetitions × 5 s rest), a passive stretch (PS) was applied with the load in place until hip flexor muscle strength dropped from 5/5 to 3+/5 according to manual muscle test. All participants underwent gait analysis before and after PS to compare sagittal plane hip, knee, and ankle kinematics and kinetics and temporo-spatial parameters. Paired t-test was used to compare pre- and post-stretch findings and Pearson correlation coefficient (r) was calculated to determine strength of correlation between SKG parameters and gait parameters of interest (p < 0.05). Reduced hip flexion velocity (mean: 21.5%; p = 0.005) was a contributor to SKG, decreasing peak knee flexion (PKF) (-20%; p = 0.0008), total knee range (-18.9%; p = 0.003), and range of knee flexion between toe-off and PKF (-26.7%; p = 0.001), and shortening duration between toe-off to PKF (-16.3%; p = 0.0005). These findings verify that any treatment protocol that slows hip flexion during gait by weakening iliopsoas muscle may have great potential to produce SKG pattern combined with reduced gait velocity. Copyright © 2016 Turkish Association of Orthopaedics and Traumatology. Production and hosting by Elsevier B.V. All rights reserved.

  8. Estimating the frequency interval of a regularly spaced multicomponent harmonic line signal in colored noise

    NASA Astrophysics Data System (ADS)

    Frazer, Gordon J.; Anderson, Stuart J.

    1997-10-01

    The radar returns from some classes of time-varying point targets can be represented by the discrete-time signal plus noise model: xt equals st plus [vt plus (eta) t] equals (summation)i equals o P minus 1 Aiej2(pi f(i)/f(s)t) plus vt plus (eta) t, t (epsilon) 0, . . ., N minus 1, fi equals kfI plus fo where the received signal xt corresponds to the radar return from the target of interest from one azimuth-range cell. The signal has an unknown number of components, P, unknown complex amplitudes Ai and frequencies fi. The frequency parameters fo and fI are unknown, although constrained such that fo less than fI/2 and parameter k (epsilon) {minus u, . . ., minus 2, minus 1, 0, 1, 2, . . ., v} is constrained such that the component frequencies fi are bound by (minus fs/2, fs/2). The noise term vt, is typically colored, and represents clutter, interference and various noise sources. It is unknown, except that (summation)tvt2 less than infinity; in general, vt is not well modelled as an auto-regressive process of known order. The additional noise term (eta) t represents time-invariant point targets in the same azimuth-range cell. An important characteristic of the target is the unknown parameter, fI, representing the frequency interval between harmonic lines. It is desired to determine an estimate of fI from N samples of xt. We propose an algorithm to estimate fI based on Thomson's harmonic line F-Test, which is part of the multi-window spectrum estimation method and demonstrate the proposed estimator applied to target echo time series collected using an experimental HF skywave radar.

  9. Prediction of Rate Constant for Supramolecular Systems with Multiconfigurations.

    PubMed

    Guo, Tao; Li, Haiyan; Wu, Li; Guo, Zhen; Yin, Xianzhen; Wang, Caifen; Sun, Lixin; Shao, Qun; Gu, Jingkai; York, Peter; Zhang, Jiwen

    2016-02-25

    The control of supramolecular systems requires a thorough understanding of their dynamics, especially on a molecular level. It is extremely difficult to determine the thermokinetic parameters of supramolecular systems, such as drug-cyclodextrin complexes with fast association/dissociation processes by experimental techniques. In this paper, molecular modeling combined with novel mathematical relationships integrating the thermodynamic/thermokinetic parameters of a series of isomeric multiconfigurations to predict the overall parameters in a range of pH values have been employed to study supramolecular dynamics at the molecular level. A suitable form of Eyring's equation was derived and a two-stage model was introduced. The new approach enabled accurate prediction of the apparent dissociation/association (k(off)/k(on)) and unbinding/binding (k-r/kr) rate constants of the ubiquitous multiconfiguration complexes of the supramolecular system. The pyronine Y (PY) was used as a model system for the validation of the presented method. Interestingly, the predicted k(off) value ((40 ± 1) × 10(5) s(-1), 298 K) of PY is largely in agreement with that previously determined by fluorescence correlation spectroscopy ((5 ± 3) × 10(5) s(-1), 298 K). Moreover, the k(off)/k(on) and k-r/kr for flurbiprofen-β-cylcodextrin and ibuprofen-β-cyclodextrin systems were also predicted and suggested that the association processes are diffusion-controlled. The methodology is considered to be especially useful in the design and selection of excipients for a supramolecular system with preferred association and dissociation rate constants and understanding their mechanisms. It is believed that this new approach could be applicable to a wide range of ligand-receptor supramolecular systems and will surely help in understanding their complex mechanism.

  10. Nonlinear dynamics of solitary and optically injected two-element laser arrays with four different waveguide structures: a numerical study.

    PubMed

    Li, Nianqiang; Susanto, H; Cemlyn, B R; Henning, I D; Adams, M J

    2018-02-19

    We study the nonlinear dynamics of solitary and optically injected two-element laser arrays with a range of waveguide structures. The analysis is performed with a detailed direct numerical simulation, where high-resolution dynamic maps are generated to identify regions of dynamic instability in the parameter space of interest. Our combined one- and two-parameter bifurcation analysis uncovers globally diverse dynamical regimes (steady-state, oscillation, and chaos) in the solitary laser arrays, which are greatly influenced by static design waveguiding structures, the amplitude-phase coupling factor of the electric field, i.e. the linewidth-enhancement factor, as well as the control parameter, e.g. the pump rate. When external optical injection is introduced to one element of the arrays, we show that the whole system can be either injection-locked simultaneously or display rich, different dynamics outside the locking region. The effect of optical injection is to significantly modify the nature and the regions of nonlinear dynamics from those found in the solitary case. We also show similarities and differences (asymmetry) between the oscillation amplitude of the two elements of the array in specific well-defined regions, which hold for all the waveguiding structures considered. Our findings pave the way to a better understanding of dynamic instability in large arrays of lasers.

  11. Peristaltic flow of Powell-Eyring fluid in curved channel with heat transfer: A useful application in biomedicine.

    PubMed

    Hina, S; Mustafa, M; Hayat, T; Alsaedi, A

    2016-10-01

    In this work, we explore the heat transfer characteristics in the peristaltic transport of Powell-Eyring fluid inside a curved channel with complaint walls. The study has motivation toward the understanding of blood flow in microcirculatory system. Formulation is developed in the existence of velocity slip and temperature jump conditions. Perturbation approach has been utilized to present series expressions of axial velocity and temperature distributions. Streamlines are prepared to analyze the interesting phenomenon of trapping. Moreover, the plots of heat transfer coefficient for a broad range of embedded parameters are presented and discussed. The results indicate that slip effects substantially influence the velocity and temperature distributions. Axial flow accelerates when slip parameter is incremented. Temperature rises and wall heat flux grows when viscous dissipation effect is strengthened. In contrast to the planar channels, here velocity and temperature functions do not exhibit symmetry with respect to the central line. In addition, bolus size and its shape are different in upper and lower portions of the channel. Heat transfer coefficient enlarges when the curvature effects are reduced. The behaviors of wall tension and wall mass parameters on the profiles are qualitatively similar. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  12. Solid-state NMR calculations for metal oxides and gallates: Shielding and quadrupolar parameters for perovskites and related phases

    NASA Astrophysics Data System (ADS)

    Middlemiss, Derek S.; Blanc, Frédéric; Pickard, Chris J.; Grey, Clare P.

    2010-05-01

    The NMR parameters obtained from solid-state DFT calculations within the GIPAW approach for 17O- and 69/71Ga-sites in a range of predominantly oxide-based (group II monoxides, SrTiO 3, BaZrO 3, BaSnO 3, BaTiO 3, LaAlO 3, LaGaO 3, SrZrO 3, MgSiO 3 and Ba 2In 2O 5), and gallate (α- and β-Ga 2O 3, LiGaO 2, NaGaO 2, GaPO 4 and LaGaO 3) materials are compared with experimental values, with a view to the future application of a similar approach to doped phases of interest as candidate intermediate temperature solid oxide fuel cell (ITSOFC) electrolytes. Isotropic and anisotropic chemical shift parameters, quadrupolar coupling constants, and associated asymmetries are presented and analyzed. The unusual GaO 5 site occurring in LaGaGe 2O 7 is also fully characterised. In general, it is found that the theoretical results closely track the experimental trends, though some deviations are identified and discussed, particularly in regard to quadrupolar ηQ-values. The high quality of the computed results suggests that this approach can be extended to study more complex and disordered phases.

  13. Tokunaga river networks: New empirical evidence and applications to transport problems

    NASA Astrophysics Data System (ADS)

    Tejedor, A.; Zaliapin, I. V.

    2013-12-01

    The Tokunaga self-similarity has proven to be an important constraint for the observed river networks. Notably, various Horton laws are naturally satisfied by the Tokunaga networks, which makes this model of considerable interest for theoretical analysis and modeling of environmental transport. Recall that Horton self-similarity is a weaker property of a tree graph that addresses its principal branching; it is a counterpart of the power-law size distribution for system's elements. The stronger Tokunaga self-similarity addresses so-called side branching; it ensures that different levels of a hierarchy have the same probabilistic structure (in a sense that can be rigorously defined). We describe an improved statistical framework for testing self-similarity in a finite tree and estimating the related parameters. The developed inference is applied to the major river basins in continental United States and Iberian Peninsula. The results demonstrate the validity of the Tokunaga model for the majority of the examined networks with very narrow (universal) range of parameter values. Next, we explore possible relationships between the Tokunaga parameter anomalies (deviations from the universal values) and climatic and geomorphologic characteristics of a region. Finally, we apply the Tokunaga model to explore vulnerability of river networks, defined via reaction of the river discharge to a storm.

  14. Physical Parameters of the Pre-WN Candidate HD326823

    NASA Astrophysics Data System (ADS)

    de Araujo, F. X.; Marcolino, W. L. F.; Borges Fernándes, M.

    2006-06-01

    HD326823 is a massive and luminous star characterized mainly by the presence of very intense HeI emission lines. From qualitative spectroscopic studies it was proposed by Lopes et al. (1992, A&A, 261, 482) and Borges Fernándes et al. (2001, ApJS, 136, 747) that this interesting object is in a pre-WN stage of evolution. In the present work we reinforce this conclusion, thanks to the estimate of its physical parameters like mass loss rate and especially chemical abundances. The data analysed by us were obtained at ESO 2.2-m telescope, with the spectrograph FEROS (R=48000) on April, 2005. The method employed to obtain the parameters is the fitting of HI, HeI and NII emission lines. In order to do this we have used the CMFGEN code, developed by J. Hilliers and colaborators (see, for instance, Hiller & Miller 1998, ApJ, 496, 407). This code is adequate for the modelling of lines produced in an expanding atmosphere and it includes important effects like line-blanketting and clumping. Preliminary results indicate a mass loss rate in the range and a clear overabundance of helium. As nitrogen abundance is concerned, it also indicates a tendency of increased abundance, but the result is not so firm in this case.

  15. The effect of charge transfer fluctuation on superconductivity in high temperature superconductors

    NASA Astrophysics Data System (ADS)

    Liu, Yihsuan; Wu, Huan-Kuang; Lee, Ting-Kuo

    H i g h - Tc Cuprates have been studied quite often as an effective one band t - J model that neglects charge fluctuation between oxygen 2p6 band and copper 3d10 band, and Zhang-Rice singlet is just a hole in the model. However, recent Scanning Tunneling Spectra(STS) measurement on underdoped Cuprate shows that charge transfer gap is only of order 12 eV. This small gap necessitates a re-examination of the charge transfer fluctuation. Here we modify the t-J model by including charge transfer fluctuation allowing the formation of doubly occupied sites. For certain parameters it is similar with the t-J-U model. This model is studied via variational Monte Carlo method(VMC). Our result shows that this model can give a unified behavior of superconducting dome with different long rang hopping parameters. The anti-correlation between charge transfer gap and pairing is also confirmed. More interestingly the charge fluctuation is found to affect pairing order parameter in different ways in underdoped and overdoped regions. This work is partially supported by Taiwan Ministry of Science and Technology with Grant. MOST 105-2112-M-001-008 and calculation was supported by a National Center of High Performance Computing in Taiwan.

  16. Optimization of Parameter Ranges for Composite Tape Winding Process Based on Sensitivity Analysis

    NASA Astrophysics Data System (ADS)

    Yu, Tao; Shi, Yaoyao; He, Xiaodong; Kang, Chao; Deng, Bo; Song, Shibo

    2017-08-01

    This study is focus on the parameters sensitivity of winding process for composite prepreg tape. The methods of multi-parameter relative sensitivity analysis and single-parameter sensitivity analysis are proposed. The polynomial empirical model of interlaminar shear strength is established by response surface experimental method. Using this model, the relative sensitivity of key process parameters including temperature, tension, pressure and velocity is calculated, while the single-parameter sensitivity curves are obtained. According to the analysis of sensitivity curves, the stability and instability range of each parameter are recognized. Finally, the optimization method of winding process parameters is developed. The analysis results show that the optimized ranges of the process parameters for interlaminar shear strength are: temperature within [100 °C, 150 °C], tension within [275 N, 387 N], pressure within [800 N, 1500 N], and velocity within [0.2 m/s, 0.4 m/s], respectively.

  17. Comparison of free-breathing with navigator-controlled acquisition regimes in abdominal diffusion-weighted magnetic resonance images: Effect on ADC and IVIM statistics.

    PubMed

    Jerome, Neil P; Orton, Matthew R; d'Arcy, James A; Collins, David J; Koh, Dow-Mu; Leach, Martin O

    2014-01-01

    To evaluate the effect on diffusion-weighted image-derived parameters in the apparent diffusion coefficient (ADC) and intra-voxel incoherent motion (IVIM) models from choice of either free-breathing or navigator-controlled acquisition. Imaging was performed with consent from healthy volunteers (n = 10) on a 1.5T Siemens Avanto scanner. Parameter-matched free-breathing and navigator-controlled diffusion-weighted images were acquired, without averaging in the console, for a total scan time of ∼10 minutes. Regions of interest were drawn for renal cortex, renal pyramid, whole kidney, liver, spleen, and paraspinal muscle. An ADC diffusion model for these regions was fitted for b-values ≥ 250 s/mm(2) , using a Levenberg-Marquardt algorithm, and an IVIM model was fitted for all images using a Bayesian method. ADC and IVIM parameters from the two acquisition regimes show no significant differences for the cohort; individual cases show occasional discrepancies, with outliers in parameter estimates arising more commonly from navigator-controlled scans. The navigator-controlled acquisitions showed, on average, a smaller range of movement for the kidneys (6.0 ± 1.4 vs. 10.0 ± 1.7 mm, P = 0.03), but also a smaller number of averages collected (3.9 ± 0.1 vs. 5.5 ± 0.2, P < 0.01) in the allocated time. Navigator triggering offers no advantage in fitted diffusion parameters, whereas free-breathing appears to offer greater confidence in fitted diffusion parameters, with fewer outliers, for matched acquisition periods. Copyright © 2013 Wiley Periodicals, Inc.

  18. Bottled SAFT: A Web App Providing SAFT-γ Mie Force Field Parameters for Thousands of Molecular Fluids.

    PubMed

    Ervik, Åsmund; Mejía, Andrés; Müller, Erich A

    2016-09-26

    Coarse-grained molecular simulation has become a popular tool for modeling simple and complex fluids alike. The defining aspects of a coarse grained model are the force field parameters, which must be determined for each particular fluid. Because the number of molecular fluids of interest in nature and in engineering processes is immense, constructing force field parameter tables by individually fitting to experimental data is a futile task. A step toward solving this challenge was taken recently by Mejía et al., who proposed a correlation that provides SAFT-γ Mie force field parameters for a fluid provided one knows the critical temperature, the acentric factor and a liquid density, all relatively accessible properties. Building on this, we have applied the correlation to more than 6000 fluids, and constructed a web application, called "Bottled SAFT", which makes this data set easily searchable by CAS number, name or chemical formula. Alternatively, the application allows the user to calculate parameters for components not present in the database. Once the intermolecular potential has been found through Bottled SAFT, code snippets are provided for simulating the desired substance using the "raaSAFT" framework, which leverages established molecular dynamics codes to run the simulations. The code underlying the web application is written in Python using the Flask microframework; this allows us to provide a modern high-performance web app while also making use of the scientific libraries available in Python. Bottled SAFT aims at taking the complexity out of obtaining force field parameters for a wide range of molecular fluids, and facilitates setting up and running coarse-grained molecular simulations. The web application is freely available at http://www.bottledsaft.org . The underlying source code is available on Bitbucket under a permissive license.

  19. TU-FG-209-04: Testing of Digital Image Receptors Using AAPM TG-150’s Draft Recommendations - Investigating the Impact of Different Processing Parameters

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Finley, C; Dave, J

    Purpose: To evaluate implementation of AAPM TG-150’s draft recommendations via a parameter study for testing the performance of digital image receptors. Methods: Flat field images were acquired from 9 calibrated digital image receptors associated with 9 new portable digital radiography systems (Carestream Health, Inc.) based on the draft recommendations and manufacturer-specified calibration conditions (set of 4 images at input detector air kerma ranging from 1 to 25 µGy). Effects of exposure response function (linearized and logarithmic), ‘Presentation Intent Type’ (‘For Processing’ and ‘For Presentation’), detector orientation with respect to the anode-cathode axis (4 orientations; 900 rotations per iteration), different ROImore » sizes (5×5–40×40 mm{sup 2}) and elimination of varying dimensions of image border (0 mm i.e., without boundary elimination to 150 mm) on signal, noise, signal-to-noise ratio (SNR) and the associated nonuniformities were evaluated. Images were analyzed in Matlab and quantities were compared using ANOVA. Results: Signal, noise and SNR values averaged over 9 systems with default parameter values in draft recommendations were 4837.2±139.4, 19.7±0.9 and 246.4±10.1 (mean ± standard deviation), respectively (at input detector air kerma: 12.5 µGy). Signal, noise and SNR showed characteristic dependency on exposure response function and on ‘Presentation Intent Type’. These values were not affected by ROI size and detector orientation, but analysis showed that eliminating the edge pixels along the boundary was required for the noise parameter (coefficient of variation range for noise: 72%–106% and 3%–4% without and with boundary elimination; respectively). Local and global nonuniformities showed a similar dependence on the need for boundary elimination. Interestingly, computed non-uniformities showed agreement with manufacturer-reported values except for noise non-uniformities in two units; artifacts were seen in images from these two units highlighting the importance of independent evaluations. Conclusion: The effect of different parameters on performance characterization of digital image receptors was evaluated based on TG-150’s draft recommendations.« less

  20. Order parameters from image analysis: a honeycomb example

    NASA Astrophysics Data System (ADS)

    Kaatz, Forrest H.; Bultheel, Adhemar; Egami, Takeshi

    2008-11-01

    Honeybee combs have aroused interest in the ability of honeybees to form regular hexagonal geometric constructs since ancient times. Here we use a real space technique based on the pair distribution function (PDF) and radial distribution function (RDF), and a reciprocal space method utilizing the Debye-Waller Factor (DWF) to quantify the order for a range of honeycombs made by Apis mellifera ligustica. The PDFs and RDFs are fit with a series of Gaussian curves. We characterize the order in the honeycomb using a real space order parameter, OP 3 , to describe the order in the combs and a two-dimensional Fourier transform from which a Debye-Waller order parameter, u, is derived. Both OP 3 and u take values from [0, 1] where the value one represents perfect order. The analyzed combs have values of OP 3 from 0.33 to 0.60 and values of u from 0.59 to 0.69. RDF fits of honeycomb histograms show that naturally made comb can be crystalline in a 2D ordered structural sense, yet is more ‘liquid-like’ than cells made on ‘foundation’ wax. We show that with the assistance of man-made foundation wax, honeybees can manufacture highly ordered arrays of hexagonal cells. This is the first description of honeycomb utilizing the Debye-Waller Factor, and provides a complete analysis of the order in comb from a real-space order parameter and a reciprocal space order parameter. It is noted that the techniques used are general in nature and could be applied to any digital photograph of an ordered array.

  1. Scalable Online Network Modeling and Simulation

    DTIC Science & Technology

    2005-08-01

    ONLINE NETWORK MODELING AND SIMULATION 6. AUTHOR(S) Boleslaw Szymanski , Shivkumar Kalyanaraman, Biplab Sikdar and Christopher Carothers 5...performance for a wide range of parameter values (parameter sensitivity), understanding of protocol stability and dynamics, and studying feature ...a wide range of parameter values (parameter sensitivity), understanding of protocol stability and dynamics, and studying feature interactions

  2. Low-frequency source parameters of twelve large earthquakes. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Harabaglia, Paolo

    1993-01-01

    A global survey of the low-frequency (1-21 mHz) source characteristics of large events are studied. We are particularly interested in events unusually enriched in low-frequency and in events with a short-term precursor. We model the source time function of 12 large earthquakes using teleseismic data at low frequency. For each event we retrieve the source amplitude spectrum in the frequency range between 1 and 21 mHz with the Silver and Jordan method and the phase-shift spectrum in the frequency range between 1 and 11 mHz with the Riedesel and Jordan method. We then model the source time function by fitting the two spectra. Two of these events, the 1980 Irpinia, Italy, and the 1983 Akita-Oki, Japan, are shallow-depth complex events that took place on multiple faults. In both cases the source time function has a length of about 100 seconds. By comparison Westaway and Jackson find 45 seconds for the Irpinia event and Houston and Kanamori about 50 seconds for the Akita-Oki earthquake. The three deep events and four of the seven intermediate-depth events are fast rupturing earthquakes. A single pulse is sufficient to model the source spectra in the frequency range of our interest. Two other intermediate-depth events have slower rupturing processes, characterized by a continuous energy release lasting for about 40 seconds. The last event is the intermediate-depth 1983 Peru-Ecuador earthquake. It was first recognized as a precursive event by Jordan. We model it with a smooth rupturing process starting about 2 minutes before the high frequency origin time superimposed to an impulsive source.

  3. Comparison of thermal properties of fish collagen and bovine collagen in the temperature range 298-670K.

    PubMed

    Gauza-Włodarczyk, Marlena; Kubisz, Leszek; Mielcarek, Sławomir; Włodarczyk, Dariusz

    2017-11-01

    The increased interest in fish collagen is a consequence of the risk of exposure to Creutzfeld-Jacob disease (CJD) and the bovine spongiform encephalopathy (BSE), whose occurrence is associated with prions carried by bovine collagen. Collagen is the main biopolymer in living organisms and the main component of the skin and bones. Until the discovery of the BSE, bovine collagen had been widely used. The BSE epidemic increased the interest in new sources of collagen such as fish skin collagen (FSC) and its properties. Although the thermal properties of collagen originating from mammals have been well described, less attention has been paid to the thermal properties of FSC. Denaturation temperature is a particularly important parameter, depending on the collagen origin and hydration level. In the reported experiment, the free water and bound water release processes along with thermal denaturation process were studied by means of the differential scanning calorimetry (DSC). Measurements were carried out using a DSC 7 instrument (Elmer-Perkin), in the temperature range 298-670K. The study material was FSC derived by acidic hydration method. The bovine Achilles tendon (BAT) collagen type I was used as the control material. The thermograms recorded revealed both, exothermic and endothermic peaks. For both materials, the peaks in the temperature range of 330-360K were assigned to the release of free water and bound water. The denaturation temperatures of FSC and BAT collagen were determined as 420K and 493K, respectively. Thermal decomposition process was observed at about 500K for FSC and at about 510K for BAT collagen. These results show that FSC is less resistant to high temperature than BAT collagen. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Flow cytometric analysis of extracellular vesicle subsets in plasma: impact of swarm by particles of non-interest.

    PubMed

    Libregts, S F W M; Arkesteijn, G J A; Németh, A; Nolte-'t Hoen, E N M; Wauben, M H M

    2018-05-20

    Essentials Extracellular vesicles (EVs) in biological fluids are promising biomarkers for disease. Fluorescence-based flow cytometric analysis is suitable to detect low abundant EV subsets. Particles of non-interest can induce false-positive light scatter and fluorescent signals. Interference of particles of non-interest can be monitored by analyzing serial dilutions. Background Extracellular vesicles (EVs) in plasma are increasingly being recognized as potential biomarkers. EV analysis for diagnostic purposes should be robust and should allow analysis of EV subsets with a wide range of abundance and in a large number of patient samples. Flow cytometry offers possibilities to meet these criteria, as it allows multiparameter analysis of individual EVs. However, analysis of plasma EVs is challenging, because of their size and heterogeneity, and the presence of other submicrometer-sized particles in plasma that could interfere with EV analysis. Objectives To explore whether fluorescence-based flow cytometric analysis of EV subsets is suitable when the EVs of interest are present in low abundance in a background of non-labeled or differently labeled EVs and particles. Methods Fluorescently labeled EVs of interest were spiked at different ratios in full plasma, purified plasma components, or (non-)fluorescent polystyrene beads, and subsequently analyzed by flow cytometry with fluorescence threshold triggering. Results We found that light scatter detection of low-abundance or rare EV subsets during fluorescence threshold triggering was severely affected by particles of non-interest, owing to coincidence and swarming. Importantly, we show that interfering particles labeled with different fluorophores induced false-positive fluorescent signals on the particles of interest. These unwanted effects could only be discerned and controlled by performing serial dilutions and analyzing light scatter and fluorescence parameters. Conclusions We demonstrate how particles of non-interest in plasma can impact on the light scatter and fluorescence detection of low-abundance EVs of interest during fluorescence-based flow cytometric analysis, and provide a means to prevent erroneous data interpretation. © 2018 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

  5. Patients and medical statistics. Interest, confidence, and ability.

    PubMed

    Woloshin, Steven; Schwartz, Lisa M; Welch, H Gilbert

    2005-11-01

    People are increasingly presented with medical statistics. There are no existing measures to assess their level of interest or confidence in using medical statistics. To develop 2 new measures, the STAT-interest and STAT-confidence scales, and assess their reliability and validity. Survey with retest after approximately 2 weeks. Two hundred and twenty-four people were recruited from advertisements in local newspapers, an outpatient clinic waiting area, and a hospital open house. We developed and revised 5 items on interest in medical statistics and 3 on confidence understanding statistics. Study participants were mostly college graduates (52%); 25% had a high school education or less. The mean age was 53 (range 20 to 84) years. Most paid attention to medical statistics (6% paid no attention). The mean (SD) STAT-interest score was 68 (17) and ranged from 15 to 100. Confidence in using statistics was also high: the mean (SD) STAT-confidence score was 65 (19) and ranged from 11 to 100. STAT-interest and STAT-confidence scores were moderately correlated (r=.36, P<.001). Both scales demonstrated good test-retest repeatability (r=.60, .62, respectively), internal consistency reliability (Cronbach's alpha=0.70 and 0.78), and usability (individual item nonresponse ranged from 0% to 1.3%). Scale scores correlated only weakly with scores on a medical data interpretation test (r=.15 and .26, respectively). The STAT-interest and STAT-confidence scales are usable and reliable. Interest and confidence were only weakly related to the ability to actually use data.

  6. Kerr Reservoir LANDSAT experiment analysis for November 1980

    NASA Technical Reports Server (NTRS)

    Lecroy, S. R.

    1982-01-01

    An experiment was conducted on the waters of Kerr Reservoir to determine if reliable algorithms could be developed that relate water quality parameters to remotely sensed data. LANDSAT radiance data was used in the analysis since it is readily available and covers the area of interest on a regular basis. By properly designing the experiment, many of the unwanted variations due to atmosphere, solar, and hydraulic changes were minimized. The algorithms developed were constrained to satisfy rigorous statistical criteria before they could be considered dependable in predicting water quality parameters. A complete mix of different types of algorithms using the LANDSAT bands was generated to provide a thorough understanding of the relationships among the data involved. The study demonstrated that for the ranges measured, the algorithms that satisfactorily represented the data are mostly linear and only require a maximum of one or two LANDSAT bands. Rationing techniques did not improve the results since the initial design of the experiment minimized the errors that this procedure is effective against. Good correlations were established for inorganic suspended solids, iron, turbidity, and secchi depth.

  7. Photopolarimetric Retrievals of Snow Properties

    NASA Technical Reports Server (NTRS)

    Ottaviani, M.; van Diedenhoven, B.; Cairns, B.

    2015-01-01

    Polarimetric observations of snow surfaces, obtained in the 410-2264 nm range with the Research Scanning Polarimeter onboard the NASA ER-2 high-altitude aircraft, are analyzed and presented. These novel measurements are of interest to the remote sensing community because the overwhelming brightness of snow plagues aerosol and cloud retrievals based on airborne and spaceborne total reflection measurements. The spectral signatures of the polarized reflectance of snow are therefore worthwhile investigating in order to provide guidance for the adaptation of algorithms currently employed for the retrieval of aerosol properties over soil and vegetated surfaces. At the same time, the increased information content of polarimetric measurements allows for a meaningful characterization of the snow medium. In our case, the grains are modeled as hexagonal prisms of variable aspect ratios and microscale roughness, yielding retrievals of the grains' scattering asymmetry parameter, shape and size. The results agree with our previous findings based on a more limited data set, with the majority of retrievals leading to moderately rough crystals of extreme aspect ratios, for each scene corresponding to a single value of the asymmetry parameter.

  8. SAPO-34/AlMCM-41, as a novel hierarchical nanocomposite: preparation, characterization and investigation of synthesis factors using response surface methodology

    NASA Astrophysics Data System (ADS)

    Roohollahi, Hossein; Halladj, Rouein; Askari, Sima; Yaripour, Fereydoon

    2018-06-01

    SAPO-34/AlMCM-41, as a new hierarchical nanocomposite was successfully synthesized via hydrothermal and dry-gel conversion. In an experimental and statistical study, effect of five input parameters including synthesis period, drying temperature, NaOH/Si, water/dried-gel and SAPO% were investigated on range-order degree of mesochannels and the relative crystallinity. X-ray diffraction (XRD) patterns were recorded to characterize the ordered AlMCM-41 and crystalline SAPO-34 structures. Nitrogen adsorption-desorption technique, scanning electron microscopy (SEM), field-emission SEM (FESEM) equipped with an energy-dispersive X-ray spectroscopy (EDS-Map) and transmission electron microscopy (TEM) were used to study the textural properties, morphology and surface elemental composition. Two reduced polynomials were fitted to the responses with good precision. Further, based on analysis of variances, SAPO% and time duration of dry-gel conversion were observed as the most effective parameters on the composite structure. The hierarchical porosity, narrow pore size distribution, high external surface area and large specific pore volume were of interesting characteristics for this novel nanocomposite.

  9. First Volcanological-Probabilistic Pyroclastic Density Current and Fallout Hazard Map for Campi Flegrei and Somma Vesuvius Volcanoes.

    NASA Astrophysics Data System (ADS)

    Mastrolorenzo, G.; Pappalardo, L.; Troise, C.; Panizza, A.; de Natale, G.

    2005-05-01

    Integrated volcanological-probabilistic approaches has been used in order to simulate pyroclastic density currents and fallout and produce hazard maps for Campi Flegrei and Somma Vesuvius areas. On the basis of the analyses of all types of pyroclastic flows, surges, secondary pyroclastic density currents and fallout events occurred in the volcanological history of the two volcanic areas and the evaluation of probability for each type of events, matrixs of input parameters for a numerical simulation have been performed. The multi-dimensional input matrixs include the main controlling parameters of the pyroclasts transport and deposition dispersion, as well as the set of possible eruptive vents used in the simulation program. Probabilistic hazard maps provide of each points of campanian area, the yearly probability to be interested by a given event with a given intensity and resulting demage. Probability of a few events in one thousand years are typical of most areas around the volcanoes whitin a range of ca 10 km, including Neaples. Results provide constrains for the emergency plans in Neapolitan area.

  10. The Efficiency of Split Panel Designs in an Analysis of Variance Model

    PubMed Central

    Wang, Wei-Guo; Liu, Hai-Jun

    2016-01-01

    We consider split panel design efficiency in analysis of variance models, that is, the determination of the cross-sections series optimal proportion in all samples, to minimize parametric best linear unbiased estimators of linear combination variances. An orthogonal matrix is constructed to obtain manageable expression of variances. On this basis, we derive a theorem for analyzing split panel design efficiency irrespective of interest and budget parameters. Additionally, relative estimator efficiency based on the split panel to an estimator based on a pure panel or a pure cross-section is present. The analysis shows that the gains from split panel can be quite substantial. We further consider the efficiency of split panel design, given a budget, and transform it to a constrained nonlinear integer programming. Specifically, an efficient algorithm is designed to solve the constrained nonlinear integer programming. Moreover, we combine one at time designs and factorial designs to illustrate the algorithm’s efficiency with an empirical example concerning monthly consumer expenditure on food in 1985, in the Netherlands, and the efficient ranges of the algorithm parameters are given to ensure a good solution. PMID:27163447

  11. Fractional time-dependent apparent viscosity model for semisolid foodstuffs

    NASA Astrophysics Data System (ADS)

    Yang, Xu; Chen, Wen; Sun, HongGuang

    2017-10-01

    The difficulty in the description of thixotropic behaviors in semisolid foodstuffs is the time dependent nature of apparent viscosity under constant shear rate. In this study, we propose a novel theoretical model via fractional derivative to address the high demand by industries. The present model adopts the critical parameter of fractional derivative order α to describe the corresponding time-dependent thixotropic behavior. More interestingly, the parameter α provides a quantitative insight into discriminating foodstuffs. With the re-exploration of three groups of experimental data (tehineh, balangu, and natillas), the proposed methodology is validated in good applicability and efficiency. The results show that the present fractional apparent viscosity model performs successfully for tested foodstuffs in the shear rate range of 50-150 s^{ - 1}. The fractional order α decreases with the increase of temperature at low temperature, below 50 °C, but increases with growing shear rate. While the ideal initial viscosity k decreases with the increase of temperature, shear rate, and ingredient content. It is observed that the magnitude of α is capable of characterizing the thixotropy of semisolid foodstuffs.

  12. Short-term scheduling of an open-pit mine with multiple objectives

    NASA Astrophysics Data System (ADS)

    Blom, Michelle; Pearce, Adrian R.; Stuckey, Peter J.

    2017-05-01

    This article presents a novel algorithm for the generation of multiple short-term production schedules for an open-pit mine, in which several objectives, of varying priority, characterize the quality of each solution. A short-term schedule selects regions of a mine site, known as 'blocks', to be extracted in each week of a planning horizon (typically spanning 13 weeks). Existing tools for constructing these schedules use greedy heuristics, with little optimization. To construct a single schedule in which infrastructure is sufficiently utilized, with production grades consistently close to a desired target, a planner must often run these heuristics many times, adjusting parameters after each iteration. A planner's intuition and experience can evaluate the relative quality and mineability of different schedules in a way that is difficult to automate. Of interest to a short-term planner is the generation of multiple schedules, extracting available ore and waste in varying sequences, which can then be manually compared. This article presents a tool in which multiple, diverse, short-term schedules are constructed, meeting a range of common objectives without the need for iterative parameter adjustment.

  13. Applying transfer matrix method to the estimation of the modal characteristics of the NASA Mini-Mass Truss

    NASA Technical Reports Server (NTRS)

    Shen, Ji-Yao; Taylor, Lawrence W., Jr.

    1994-01-01

    It is beneficial to use a distributed parameter model for large space structures because the approach minimizes the number of model parameters. Holzer's transfer matrix method provides a useful means to simplify and standardize the procedure for solving the system of partial differential equations. Any large space structures can be broken down into sub-structures with simple elastic and dynamical properties. For each single element, such as beam, tether, or rigid body, we can derive the corresponding transfer matrix. Combining these elements' matrices enables the solution of the global system equations. The characteristics equation can then be formed by satisfying the appropriate boundary conditions. Then natural frequencies and mode shapes can be determined by searching the roots of the characteristic equation at frequencies within the range of interest. This paper applies this methodology, and the maximum likelihood estimation method, to refine the modal characteristics of the NASA Mini-Mast Truss by successively matching the theoretical response to the test data of the truss. The method is being applied to more complex configurations.

  14. Design of a C- Band Circular Polarization Microstrip Antenna

    NASA Astrophysics Data System (ADS)

    Yohandri; Jumiah, Yusna; Tetuko Sri Sumantyo, Josaphat

    2018-04-01

    The development of circularly polarized microstrip antenna is an interesting topic in current research, due to its superiority in various applications. In this work, the design of a circular polarization antenna that will be operated in the C-band range will be described. The developed antenna is intended to be used for Synthetic Aperture Radar (SAR) applications. Through this application, various targets or areas on the surface of the earth, such as buildings, soil and land can be observed. To get the ideal antenna characteristic, in this research the various parameters in antenna design will be simulated. A software CST Studio will be operated in this simulation. Based on the simulation results, the optimum parameters are obtained in term of reflection coefficient, VSWR, axial ratio, and gain. The reflection coefficient of the antenna (S11) is obtained at -19.75 dB and VSWR of 1.23. Meanwhile, the axial ratio and gain of the antenna were obtained at 2.66 dB and 2.1 dBi, respectively. Based on this simulated results, antenna design is potential to be developed and fabricated for SAR sensor applications.

  15. Intelligent Systems for Stabilizing Mode-Locked Lasers and Frequency Combs: Machine Learning and Equation-Free Control Paradigms for Self-Tuning Optics

    NASA Astrophysics Data System (ADS)

    Kutz, J. Nathan; Brunton, Steven L.

    2015-12-01

    We demonstrate that a software architecture using innovations in machine learning and adaptive control provides an ideal integration platform for self-tuning optics. For mode-locked lasers, commercially available optical telecom components can be integrated with servocontrollers to enact a training and execution software module capable of self-tuning the laser cavity even in the presence of mechanical and/or environmental perturbations, thus potentially stabilizing a frequency comb. The algorithm training stage uses an exhaustive search of parameter space to discover best regions of performance for one or more objective functions of interest. The execution stage first uses a sparse sensing procedure to recognize the parameter space before quickly moving to the near optimal solution and maintaining it using the extremum seeking control protocol. The method is robust and equationfree, thus requiring no detailed or quantitatively accurate model of the physics. It can also be executed on a broad range of problems provided only that suitable objective functions can be found and experimentally measured.

  16. Analysis of network motifs in cellular regulation: Structural similarities, input-output relations and signal integration.

    PubMed

    Straube, Ronny

    2017-12-01

    Much of the complexity of regulatory networks derives from the necessity to integrate multiple signals and to avoid malfunction due to cross-talk or harmful perturbations. Hence, one may expect that the input-output behavior of larger networks is not necessarily more complex than that of smaller network motifs which suggests that both can, under certain conditions, be described by similar equations. In this review, we illustrate this approach by discussing the similarities that exist in the steady state descriptions of a simple bimolecular reaction, covalent modification cycles and bacterial two-component systems. Interestingly, in all three systems fundamental input-output characteristics such as thresholds, ultrasensitivity or concentration robustness are described by structurally similar equations. Depending on the system the meaning of the parameters can differ ranging from protein concentrations and affinity constants to complex parameter combinations which allows for a quantitative understanding of signal integration in these systems. We argue that this approach may also be extended to larger regulatory networks. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Characterization of Musa sp. fruits and plantain banana ripening stages according to their physicochemical attributes.

    PubMed

    Valérie Passo Tsamo, Claudine; Andre, Christelle M; Ritter, Christian; Tomekpe, Kodjo; Ngoh Newilah, Gérard; Rogez, Hervé; Larondelle, Yvan

    2014-08-27

    This study aimed at understanding the contribution of the fruit physicochemical parameters to Musa sp. diversity and plantain ripening stages. A discriminant analysis was first performed on a collection of 35 Musa sp. cultivars, organized in six groups based on the consumption mode (dessert or cooking banana) and the genomic constitution. A principal component analysis reinforced by a logistic regression on plantain cultivars was proposed as an analytical approach to describe the plantain ripening stages. The results of the discriminant analysis showed that edible fraction, peel pH, pulp water content, and pulp total phenolics were among the most contributing attributes for the discrimination of the cultivar groups. With mean values ranging from 65.4 to 247.3 mg of gallic acid equivalents/100 g of fresh weight, the pulp total phenolics strongly differed between interspecific and monospecific cultivars within dessert and nonplantain cooking bananas. The results of the logistic regression revealed that the best models according to fitting parameters involved more than one physicochemical attribute. Interestingly, pulp and peel total phenolic contents contributed in the building up of these models.

  18. A Software Toolkit to Study Systematic Uncertainties of the Physics Models of the Geant4 Simulation Package

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Genser, Krzysztof; Hatcher, Robert; Kelsey, Michael

    The Geant4 simulation toolkit is used to model interactions between particles and matter. Geant4 employs a set of validated physics models that span a wide range of interaction energies. These models rely on measured cross-sections and phenomenological models with the physically motivated parameters that are tuned to cover many application domains. To study what uncertainties are associated with the Geant4 physics models we have designed and implemented a comprehensive, modular, user-friendly software toolkit that allows the variation of one or more parameters of one or more Geant4 physics models involved in simulation studies. It also enables analysis of multiple variantsmore » of the resulting physics observables of interest in order to estimate the uncertainties associated with the simulation model choices. Based on modern event-processing infrastructure software, the toolkit offers a variety of attractive features, e.g. exible run-time con gurable work ow, comprehensive bookkeeping, easy to expand collection of analytical components. Design, implementation technology, and key functionalities of the toolkit are presented in this paper and illustrated with selected results.« less

  19. Modeling viscous dissipation during vocal fold contact: the influence of tissue viscosity and thickness with implications for hydration.

    PubMed

    Erath, Byron D; Zañartu, Matías; Peterson, Sean D

    2017-06-01

    The mechanics of vocal fold contact during phonation is known to play a crucial role in both normal and pathological speech production, though the underlying physics is not well understood. Herein, a viscoelastic model of the stresses during vocal fold contact is developed. This model assumes the cover to be a poroelastic structure wherein interstitial fluid translocates in response to mechanical squeezing. The maximum interstitial fluid pressure is found to generally increase with decreasing viscous dissipation and/or decreasing tissue elasticity. A global minimum in the total contact stress, comprising interstitial fluid pressure and elastic stress in the tissue, is observed over the studied dimensionless parameter range. Interestingly, physiologically reasonable estimates for the governing parameters fall within this global minimum region. The model is validated against prior experimental and computational work, wherein the predicted contact stress magnitude and impact duration agree well with published results. Lastly, observations of the potential relationship between vocal fold hydration and increased risk of tissue damage are discussed based upon model predictions of stress as functions of cover layer thickness and viscosity.

  20. Effect of Torsion on the Friction Factor of Helical Pipe Flow

    NASA Astrophysics Data System (ADS)

    Kumer Datta, Anup; Yanase, Shinichiro; Hayamizu, Yasutaka; Kouchi, Toshinori; Nagata, Yasunori; Yamamoto, Kyoji

    2017-06-01

    Three-dimensional direct numerical simulations of a viscous incompressible fluid flow through a helical pipe with a circular cross section were conducted for three Reynolds numbers, Re (= 80, 300, and 1000), and two nondimensional curvatures, δ (= 0.1 and 0.05), over a wide range of torsion parameters, β (= nondimensional torsion/√{2δ } ), from 0.02 to 2.8. Well-developed axially invariant regions were obtained where the friction factors were calculated, in good agreement with the experimental data obtained by Yamamoto et al. [https://doi.org/10.1016/0169-5983(95)00022-6, Fluid Dyn. Res. 16, 237 (1995)]. It was found that the friction factor sharply increases as β increases from zero, then decreases after taking a maximum, and finally slowly approaches that of a straight pipe when β tends to infinity. It is interesting that a peak of the friction factor exists in the region 0.2 ≤ β ≤ 0.3 for all the Reynolds numbers and curvatures studied in the present paper, which manifests the importance of the torsion parameter in helical pipe flow.

  1. SERS activity of silver and gold nanostructured thin films deposited by pulsed laser ablation

    NASA Astrophysics Data System (ADS)

    Agarwal, N. R.; Tommasini, M.; Fazio, E.; Neri, F.; Ponterio, R. C.; Trusso, S.; Ossi, P. M.

    2014-10-01

    Nanostructured Au and Ag thin films were obtained by nanosecond pulsed laser ablation in presence of a controlled Ar atmosphere. Keeping constant other deposition parameters such as target-to-substrate distance, incidence angle, laser wavelength and laser fluence, the film morphology, revealed by SEM, ranges from isolated NPs to island structures and sensibly depends on gas pressure (10-100 Pa) and on the laser pulse number (500-3 × 10). The control of these two parameters allows tailoring the morphology and correspondingly the optical properties of the films. The position and width of the surface plasmon resonance peak, in fact, can be varied with continuity. The films showed remarkable surface-enhanced Raman activity (SERS) that depends on the adopted deposition conditions. Raman maps were acquired on micrometer-sized areas of both silver and gold substrates selected among those with the strongest SERS activity. Organic dyes of interest in cultural heritage studies (alizarin, purpurin) have been also considered for bench marking the substrates produced in this work. Also the ability to detect the presence of biomolecules was tested using lysozyme in a label free configuration.

  2. Mathematical properties and parameter estimation for transit compartment pharmacodynamic models.

    PubMed

    Yates, James W T

    2008-07-03

    One feature of recent research in pharmacodynamic modelling has been the move towards more mechanistically based model structures. However, in all of these models there are common sub-systems, such as feedback loops and time-delays, whose properties and contribution to the model behaviour merit some mathematical analysis. In this paper a common pharmacodynamic model sub-structure is considered: the linear transit compartment. These models have a number of interesting properties as the length of the cascade chain is increased. In the limiting case a pure time-delay is achieved [Milsum, J.H., 1966. Biological Control Systems Analysis. McGraw-Hill Book Company, New York] and the initial behaviour becoming increasingly sensitive to parameter value perturbation. It is also shown that the modelled drug effect is attenuated, though the duration of action is longer. Through this analysis the range of behaviours that such models are capable of reproducing are characterised. The properties of these models and the experimental requirements are discussed in order to highlight how mathematical analysis prior to experimentation can enhance the utility of mathematical modelling.

  3. Weyl semimetals in optical lattices: moving and merging of Weyl points, and hidden symmetry at Weyl points

    PubMed Central

    Hou, Jing-Min; Chen, Wei

    2016-01-01

    We propose to realize Weyl semimetals in a cubic optical lattice. We find that there exist three distinct Weyl semimetal phases in the cubic optical lattice for different parameter ranges. One of them has two pairs of Weyl points and the other two have one pair of Weyl points in the Brillouin zone. For a slab geometry with (010) surfaces, the Fermi arcs connecting the projections of Weyl points with opposite topological charges on the surface Brillouin zone is presented. By adjusting the parameters, the Weyl points can move in the Brillouin zone. Interestingly, for two pairs of Weyl points, as one pair of them meet and annihilate, the originial two Fermi arcs coneect into one. As the remaining Weyl points annihilate further, the Fermi arc vanishes and a gap is opened. Furthermore, we find that there always exists a hidden symmetry at Weyl points, regardless of anywhere they located in the Brillouin zone. The hidden symmetry has an antiunitary operator with its square being −1. PMID:27644114

  4. Inert gas thrusters

    NASA Technical Reports Server (NTRS)

    Kaufman, H. R.

    1976-01-01

    Inert gases are of interest as possible alternatives to the usual electric thruster propellants of mercury and cesium. The multipole discharge chamber investigated was shown capable of low discharge chamber losses and flat ion beam profiles with a minimum of optimization. Minimum discharge losses were 200 to 250 eV/ion for xenon and 300 to 350 eV/ion for argon, while flatness parameters in the plane of the accelerator grid were 0.85 to 0.95. The design used employs low magnetic field strengths, which permits the use of sheet-metal parts. The corner problem of the discharge chamber was resolved with recessed corner anodes, which approximately equalized both the magnetic field above the anodes and the electron currents to these anodes. Argon hollow cathodes were investigated at currents up to about 5 amperes using internal thermionic emitters. Cathode chamber diameter optimized in the 1.0 to 2.5 cm range, while orifices diameter optimized in the 0.5 to 5 mm range. The use of a bias voltage for the internal emitter extended the operating range and facilitated starting. The masses of 15 and 30 cm flight type thrusters were estimated at about 4.2 and 10.8 kg.

  5. Effect of Elevated Free Stream Turbulence on the Hydrodynamic Performance of a Tidal Turbine Blade Section

    NASA Astrophysics Data System (ADS)

    Vinod, Ashwin; Lawrence, Angela; Banerjee, Arindam

    2016-11-01

    The effects of elevated freestream turbulence (FST) on the performance of a tidal turbine blade is studied using laboratory experiments. Of interest for the current investigation is elevated levels of FST in the range of 6-24% that is prevalent in deployment sites of tidal turbines. A constant chord, no twist blade section (SG6043) is tested at an operating Reynolds number of 1.5x105 and at angles of attack ranging from -90o to +90o. The parameter space encompasses the entire operational range of a tidal turbine that includes flow reversal. Multiple levels of controlled FST are achieved using an active grid type turbulence generator placed at the entrance to the water tunnel test section. The hydrodynamic loads experienced by the blade section are measured using a 3-axis load cell; a Stereo-PIV technique is used to analyze the flow field around the blade. The results indicate that elevated levels of FST cause a delay in flow separation when compared to the case of a laminar freestream. Furthermore, the lift to drag ratio of the blade is considerably altered depending on the level of FST and angle of attack tested.

  6. Soviet Interests in Afghanistan and Implications upon Withdrawal

    DTIC Science & Technology

    1990-06-01

    Causes of the Invasion ................ 87 Protection of Long -Standing Soviet Investments in Afghanistan .......... 88 Security Concerns...its denial to the West, if necessary, have always remained a priority long -range economic interest.L0 SECURITY OF FRONTIERS From Czarist times, the...territory, perhaps with a long -range goal of securing a warm water port. With the passage of time, Russian interests additionally included balancing

  7. Dynamic Contrast-Enhanced MRI in Head-and-Neck Cancer: The Impact of Region of Interest Selection on the Intra- and Interpatient Variability of Pharmacokinetic Parameters

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Craciunescu, Oana I., E-mail: oana.craciunescu@duke.edu; Yoo, David S.; Cleland, Esi

    2012-03-01

    Purpose: Dynamic contrast-enhanced (DCE) MRI-extracted parameters measure tumor microvascular physiology and are usually calculated from an intratumor region of interest (ROI). Optimal ROI delineation is not established. The valid clinical use of DCE-MRI requires that the variation for any given parameter measured within a tumor be less than that observed between tumors in different patients. This work evaluates the impact of tumor ROI selection on the assessment of intra- and interpatient variability. Method and Materials: Head and neck cancer patients received initial targeted therapy (TT) treatment with erlotinib and/or bevacizumab, followed by radiotherapy and concurrent cisplatin with synchronous TT. DCE-MRImore » data from Baseline and the end of the TT regimen (Lead-In) were analyzed to generate the vascular transfer function (K{sup trans}), the extracellular volume fraction (v{sub e}), and the initial area under the concentration time curve (iAUC{sub 1min}). Four ROI sampling strategies were used: whole tumor or lymph node (Whole), the slice containing the most enhancing voxels (SliceMax), three slices centered in SliceMax (Partial), and the 5% most enhancing contiguous voxels within SliceMax (95Max). The average coefficient of variation (aCV) was calculated to establish intrapatient variability among ROI sets and interpatient variability for each ROI type. The average ratio between each intrapatient CV and the interpatient CV was calculated (aRCV). Results: Baseline primary/nodes aRCVs for different ROIs not including 95Max were, for all three MR parameters, in the range of 0.14-0.24, with Lead-In values between 0.09 and 0.2, meaning a low intrapatient vs. interpatient variation. For 95Max, intrapatient CVs approximated interpatient CVs, meaning similar data dispersion and higher aRCVs (0.6-1.27 for baseline) and 0.54-0.95 for Lead-In. Conclusion: Distinction between different patient's primary tumors and/or nodes cannot be made using 95Max ROIs. The other three strategies are viable and equivalent for using DCE-MRI to measure head and neck cancer physiology.« less

  8. Performance of medical students on a virtual reality simulator for knee arthroscopy: an analysis of learning curves and predictors of performance.

    PubMed

    Rahm, Stefan; Wieser, Karl; Wicki, Ilhui; Holenstein, Livia; Fucentese, Sandro F; Gerber, Christian

    2016-03-25

    Ethical concerns for surgical training on patients, limited working hours with fewer cases per trainee and the potential to better select talented persons for arthroscopic surgery raise the interest in simulator training for arthroscopic surgery. It was the purpose of this study to analyze learning curves of novices using a knee arthroscopy simulator and to correlate their performance with potentially predictive factors. Twenty medical students completed visuospatial tests and were then subjected to a simulator training program of eight 30 min sessions. Their test results were quantitatively correlated with their simulator performance at initiation, during and at the end of the program. The mean arthroscopic performance score (z-score in points) at the eight test sessions were 1. -35 (range, -126 to -5) points, 2. -16 (range, -30 to -2), 3. -11 (range, -35 to 4), 4. -3 (range, -16 to 5), 5. -2 (range, -28 to 7), 6. 1 (range, -18 to 8), 7. 2 (range, -9 to 8), 8. 2 (range, -4 to 7). Scores improved significantly from sessions 1 to 2 (p = 0.001), 2 to 3 (p = 0.052) and 3 to 4 (p = 0.001) but not thereafter. None of the investigated parameters predicted performance or development of arthroscopic performance. Novices improve significantly within four 30 min test virtual arthroscopy knee simulator training but not thereafter within the setting studied. No factors, predicting talent or speed and magnitude of improvement of skills could be identified.

  9. Roaming behaviour and home range estimation of domestic dogs in Aboriginal and Torres Strait Islander communities in northern Australia using four different methods.

    PubMed

    Dürr, Salome; Ward, Michael P

    2014-11-15

    Disease transmission parameters are the core of epidemic models, but are difficult to estimate, especially in the absence of outbreak data. Investigation of the roaming behaviour, home range (HR) and utilization distribution (UD) can provide the foundation for such parameter estimation in free-ranging animals. The objectives of this study were to estimate HR and UD of 69 domestic dogs in six Aboriginal and Torres Strait Islander communities in northern Australia and to compare four different methods (the minimum convex polygon, MCP; the location-based kernel density estimation, LKDE; the biased random bridge, BRB; and Time Local Convex Hull, T-LoCoH) for investigation of UD and estimating HR sizes. Global positioning system (GPS) collars were attached to community dogs for a period of 1-3 days and positions (fixes) were recorded every minute. Median core HRs (50% isopleth) of the 69 dogs were estimated to range from 0.2 to 0.4 ha and the more extended HR (95% isopleth) to range from 2.5 to 5.3 ha, depending on the method used. The HR and UD shapes were found to be generally circular around the dog owner's house. However, some individuals were found to roam much more with a HR size of 40-104 ha and cover large areas of their community or occasionally beyond. These far roaming dogs are of particular interest for infectious disease transmission. Occasionally, dogs were taken between communities and out of communities for hunting, which enables the contact of dogs between communities and with wildlife (such as dingoes). The BRB and T-LoCoH are the only two methods applied here which integrate the consecutiveness of GPS locations into the analysis, a substantial advantage. The recently developed BRB method produced significantly larger HR estimates than the other two methods; however, the variability of HR sizes was lower compared to the other methods. Advantages of the BRB method include a more realistic analytical approach (kernel density estimation based on movements rather than on locations), possibilities to deal with irregular time periods between consecutive GPS fixes and parameter specification which respects the characteristics of the GPS unit used to collect the data. The BRB method was therefore the most suitable method for UD estimation in this dataset. The results of this study can further be used to contact rates between the dogs within and between communities, a foundation for estimating transmission parameters for canine infectious disease models, such as a rabies spread model in Australia. Crown Copyright © 2014. Published by Elsevier B.V. All rights reserved.

  10. Modeling, Dynamics, Bifurcation Behavior and Stability Analysis of a DC-DC Boost Converter in Photovoltaic Systems

    NASA Astrophysics Data System (ADS)

    Zhioua, M.; El Aroudi, A.; Belghith, S.; Bosque-Moncusí, J. M.; Giral, R.; Al Hosani, K.; Al-Numay, M.

    A study of a DC-DC boost converter fed by a photovoltaic (PV) generator and supplying a constant voltage load is presented. The input port of the converter is controlled using fixed frequency pulse width modulation (PWM) based on the loss-free resistor (LFR) concept whose parameter is selected with the aim to force the PV generator to work at its maximum power point. Under this control strategy, it is shown that the system can exhibit complex nonlinear behaviors for certain ranges of parameter values. First, using the nonlinear models of the converter and the PV source, the dynamics of the system are explored in terms of some of its parameters such as the proportional gain of the controller and the output DC bus voltage. To present a comprehensive approach to the overall system behavior under parameter changes, a series of bifurcation diagrams are computed from the circuit-level switched model and from a simplified model both implemented in PSIM© software showing a remarkable agreement. These diagrams show that the first instability that takes place in the system period-1 orbit when a primary parameter is varied is a smooth period-doubling bifurcation and that the nonlinearity of the PV generator is irrelevant for predicting this phenomenon. Different bifurcation scenarios can take place for the resulting period-2 subharmonic regime depending on a secondary bifurcation parameter. The boundary between the desired period-1 orbit and subharmonic oscillation resulting from period-doubling in the parameter space is obtained by calculating the eigenvalues of the monodromy matrix of the simplified model. The results from this model have been validated with time-domain numerical simulation using the circuit-level switched model and also experimentally from a laboratory prototype. This study can help in selecting the parameter values of the circuit in order to delimit the region of period-1 operation of the converter which is of practical interest in PV systems.

  11. Swiss Atlas of PHYsical properties of Rocks (SAPHYR)

    NASA Astrophysics Data System (ADS)

    Zappone, Alba; Kissling, Eduard

    2015-04-01

    The Swiss Atlas of PHYsical properties of Rocks (SAPHYR), is a multi-year project, funded entirely by Swiss Commission for Geophysics (SGPK), with the aim to compile a comprehensive data set in digital form on physical properties of rocks exposed in Switzerland and surrounding regions. The ultimate goal of SAPHYR is to make these data accessible to an open and wide public including industrial, engineering, land and resource planning companies, as well as academic institutions, or simply people interested in geology. Since the early sixties worldwide many scientists, i.e. geophysicists, petrologists, and engineers, focused their work on laboratory measurements of rocks physical properties, and their relations with microstructures, mineralogical compositions and other rock parameters, in the effort to constrain the geological interpretation of geophysical surveys. Particularly in the years in which seismic reflection and refraction crustal scale projects were investigating the deep structures of the Alps, laboratories capable to reproduce the pressure and temperature ranges of the continental crust were collecting measurements of various rock parameters on a wide variety of lithologies, developing in the meantime more and more sophisticated experimental methodologies. In recent years, the increasing interest of European Countries on non-traditional energy supply, (i.e. Deep Geothermal Energy and shale gas) and CO2 storage renovated the interests in physical characterization of the deep underground. SAPHYR aims to organize all those laboratory data into a geographically referenced database (GIS). The data refer to density, porosity, permeability, and seismic, magnetic, thermal and electric properties. In the past years, effort has been placed on collecting samples and measuring the physical properties of lithologies that were poorly documented in literature. The phase of laboratory measurements is still in progress. Recently, SAPHYR project focused towards developing a 3-D physical properties model of the Swiss subsurface, using the structure of the exposed geology and data from boreholes and seismic surveys, combined with empirically determined pressure and temperature derivatives. The product is now almost ready for publication and an early version is presented here.

  12. Seismic hazard estimation of northern Iran using smoothed seismicity

    NASA Astrophysics Data System (ADS)

    Khoshnevis, Naeem; Taborda, Ricardo; Azizzadeh-Roodpish, Shima; Cramer, Chris H.

    2017-07-01

    This article presents a seismic hazard assessment for northern Iran, where a smoothed seismicity approach has been used in combination with an updated seismic catalog and a ground motion prediction equation recently found to yield good fit with data. We evaluate the hazard over a geographical area including the seismic zones of Azerbaijan, the Alborz Mountain Range, and Kopeh-Dagh, as well as parts of other neighboring seismic zones that fall within our region of interest. In the chosen approach, seismic events are not assigned to specific faults but assumed to be potential seismogenic sources distributed within regular grid cells. After performing the corresponding magnitude conversions, we decluster both historical and instrumental seismicity catalogs to obtain earthquake rates based on the number of events within each cell, and smooth the results to account for the uncertainty in the spatial distribution of future earthquakes. Seismicity parameters are computed for each seismic zone separately, and for the entire region of interest as a single uniform seismotectonic region. In the analysis, we consider uncertainties in the ground motion prediction equation, the seismicity parameters, and combine the resulting models using a logic tree. The results are presented in terms of expected peak ground acceleration (PGA) maps and hazard curves at selected locations, considering exceedance probabilities of 2 and 10% in 50 years for rock site conditions. According to our results, the highest levels of hazard are observed west of the North Tabriz and east of the North Alborz faults, where expected PGA values are between about 0.5 and 1 g for 10 and 2% probability of exceedance in 50 years, respectively. We analyze our results in light of similar estimates available in the literature and offer our perspective on the differences observed. We find our results to be helpful in understanding seismic hazard for northern Iran, but recognize that additional efforts are necessary to obtain more robust estimates at specific areas of interest and different site conditions.

  13. Exploiting active subspaces to quantify uncertainty in the numerical simulation of the HyShot II scramjet

    NASA Astrophysics Data System (ADS)

    Constantine, P. G.; Emory, M.; Larsson, J.; Iaccarino, G.

    2015-12-01

    We present a computational analysis of the reactive flow in a hypersonic scramjet engine with focus on effects of uncertainties in the operating conditions. We employ a novel methodology based on active subspaces to characterize the effects of the input uncertainty on the scramjet performance. The active subspace identifies one-dimensional structure in the map from simulation inputs to quantity of interest that allows us to reparameterize the operating conditions; instead of seven physical parameters, we can use a single derived active variable. This dimension reduction enables otherwise infeasible uncertainty quantification, considering the simulation cost of roughly 9500 CPU-hours per run. For two values of the fuel injection rate, we use a total of 68 simulations to (i) identify the parameters that contribute the most to the variation in the output quantity of interest, (ii) estimate upper and lower bounds on the quantity of interest, (iii) classify sets of operating conditions as safe or unsafe corresponding to a threshold on the output quantity of interest, and (iv) estimate a cumulative distribution function for the quantity of interest.

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ashraf, M. Bilal, E-mail: bilalashraf-qau@yahoo.com; Hayat, T.; Department of Mathematics, Faculty of Science, King Abdulaziz University, P. O. Box 80257, Jeddah 21589

    Three dimensional radiative flow of Maxwell fluid over an inclined stretching surface with convective boundary condition is investigated. Heat and mass transfer analysis is taken into account with thermophoresis effects. Similarity transformations are utilized to reduce the partial differential equations into ordinary differential equations. Series solutions of velocity, temperature and concentration are developed. Influence of different parameters Biot number, therrmophoretic parameter, Deborah number, ratio parameter, inclined stretching angle, radiation parameter, mixed convection parameter and concentration buoyancy parameter on the non-dimensional velocity components, temperature and concentration are plotted and discussed in detail. Physical quantities of interests are tabulated and examined.

  15. Process and apparatus for measuring degree of polarization and angle of major axis of polarized beam of light

    DOEpatents

    Decker, Derek E.; Toeppen, John S.

    1994-01-01

    Apparatus and process are disclosed for calibrating measurements of the phase of the polarization of a polarized beam and the angle of the polarized optical beam's major axis of polarization at a diagnostic point with measurements of the same parameters at a point of interest along the polarized beam path prior to the diagnostic point. The process is carried out by measuring the phase angle of the polarization of the beam and angle of the major axis at the point of interest, using a rotatable polarizer and a detector, and then measuring these parameters again at a diagnostic point where a compensation apparatus, including a partial polarizer, which may comprise a stack of glass plates, is disposed normal to the beam path between a rotatable polarizer and a detector. The partial polarizer is then rotated both normal to the beam path and around the axis of the beam path until the detected phase of the beam polarization equals the phase measured at the point of interest. The rotatable polarizer at the diagnostic point may then be rotated manually to determine the angle of the major axis of the beam and this is compared with the measured angle of the major axis of the beam at the point of interest during calibration. Thereafter, changes in the polarization phase, and in the angle of the major axis, at the point of interest can be monitored by measuring the changes in these same parameters at the diagnostic point.

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Isa, Sharena Mohamad; Ali, Anati

    In this paper, the hydromagnetic flow of dusty fluid over a vertical stretching sheet with thermal radiation is investigated. The governing partial differential equations are reduced to nonlinear ordinary differential equations using similarity transformation. These nonlinear ordinary differential equations are solved numerically using Runge-Kutta Fehlberg fourth-fifth order method (RKF45 Method). The behavior of velocity and temperature profiles of hydromagnetic fluid flow of dusty fluid is analyzed and discussed for different parameters of interest such as unsteady parameter, fluid-particle interaction parameter, the magnetic parameter, radiation parameter and Prandtl number on the flow.

  17. Efficient Bayesian inference for natural time series using ARFIMA processes

    NASA Astrophysics Data System (ADS)

    Graves, Timothy; Gramacy, Robert; Franzke, Christian; Watkins, Nicholas

    2016-04-01

    Many geophysical quantities, such as atmospheric temperature, water levels in rivers, and wind speeds, have shown evidence of long memory (LM). LM implies that these quantities experience non-trivial temporal memory, which potentially not only enhances their predictability, but also hampers the detection of externally forced trends. Thus, it is important to reliably identify whether or not a system exhibits LM. We present a modern and systematic approach to the inference of LM. We use the flexible autoregressive fractional integrated moving average (ARFIMA) model, which is widely used in time series analysis, and of increasing interest in climate science. Unlike most previous work on the inference of LM, which is frequentist in nature, we provide a systematic treatment of Bayesian inference. In particular, we provide a new approximate likelihood for efficient parameter inference, and show how nuisance parameters (e.g., short-memory effects) can be integrated over in order to focus on long-memory parameters and hypothesis testing more directly. We illustrate our new methodology on the Nile water level data and the central England temperature (CET) time series, with favorable comparison to the standard estimators [1]. In addition we show how the method can be used to perform joint inference of the stability exponent and the memory parameter when ARFIMA is extended to allow for alpha-stable innovations. Such models can be used to study systems where heavy tails and long range memory coexist. [1] Graves et al, Nonlin. Processes Geophys., 22, 679-700, 2015; doi:10.5194/npg-22-679-2015.

  18. Influence of meteorological parameters on air quality

    NASA Astrophysics Data System (ADS)

    Gioda, Adriana; Ventura, Luciana; Lima, Igor; Luna, Aderval

    2013-04-01

    The physical characterization representative of ambient air particle concentrations is becoming a topic of great interest for urban air quality monitoring and human exposure assessment. Human exposure to particulate matter of less than 2.5 µm in diameter (PM2.5) can result in a variety of adverse health impacts, including reduced lung function and premature mortality. Numerous studies have shown that fine airborne inhalable particulate matter particles (PM2.5) are more dangerous to human health than coarse particles, e.g. PM10. This study investigates meteorological parameter impacts on PM2.5 concentrations in the atmosphere of Rio de Janeiro, Brazil. Samples were collected during 24 h every six days using a high-volume sampler from six sites in the metropolitan area of Rio de Janeiro from January to December 2011. The particles mass was determined by Gravimetry. Meteorological parameters were obtained from automatic stations near the sampling sites. The average PM2.5 concentrations ranged from 9 to 32 µg/m3 for all sites, exceeding the suggested annual limit of WHO (10 µg/m3). The relationship between the effects of temperature, relative humidity, wind speed and direction and particle concentration was examined using a Principal Component Analysis (PCA) for the different sites and seasons. The results for each sampling point and season presented different principal component numbers, varying from 2 to 4, and extremely different relationships with the parameters. This clearly shows that changes in meteorological conditions exert a marked influence on air quality.

  19. On the predictiveness of single-field inflationary models

    NASA Astrophysics Data System (ADS)

    Burgess, C. P.; Patil, Subodh P.; Trott, Michael

    2014-06-01

    We re-examine the predictiveness of single-field inflationary models and discuss how an unknown UV completion can complicate determining inflationary model parameters from observations, even from precision measurements. Besides the usual naturalness issues associated with having a shallow inflationary potential, we describe another issue for inflation, namely, unknown UV physics modifies the running of Standard Model (SM) parameters and thereby introduces uncertainty into the potential inflationary predictions. We illustrate this point using the minimal Higgs Inflationary scenario, which is arguably the most predictive single-field model on the market, because its predictions for A S , r and n s are made using only one new free parameter beyond those measured in particle physics experiments, and run up to the inflationary regime. We find that this issue can already have observable effects. At the same time, this UV-parameter dependence in the Renormalization Group allows Higgs Inflation to occur (in principle) for a slightly larger range of Higgs masses. We comment on the origin of the various UV scales that arise at large field values for the SM Higgs, clarifying cut off scale arguments by further developing the formalism of a non-linear realization of SU L (2) × U(1) in curved space. We discuss the interesting fact that, outside of Higgs Inflation, the effect of a non-minimal coupling to gravity, even in the SM, results in a non-linear EFT for the Higgs sector. Finally, we briefly comment on post BICEP2 attempts to modify the Higgs Inflation scenario.

  20. Correlation effects in focused transmission through disordered media (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Hsu, Chia Wei; Liew, Seng Fatt; Goetschy, Arthur; Cao, Hui; Stone, A. Douglas

    2017-02-01

    By controlling the many degrees of freedom in the incident wavefront, one can manipulate wave propagation in complex structures. Such wavefront-shaping methods have been used extensively for controlling light transmitted into wavelength-scale regions (speckles), a property that is insensitive to correlations in the speckle pattern. Extending coherent control to larger regions is of great interest both scientifically and for applications such as optical communications, photothermal therapy, and the imaging of large objects within or behind a diffusive medium. However, waves diffusing through a disordered medium are known to exhibit non-local intensity correlations, and their effect on coherent control has not been fully understood. Here, we demonstrate the effects of correlations with wavefront-shaping experiments on a scattering sample of zinc oxide microparticles. Long-range correlations substantially increase the dynamic range of coherent control over light transmitted onto larger target regions, far beyond what would be achievable if correlations were negligible. This and other effects of correlations emerge when the number of speckles targeted, M2, exceeds the dimensionless conductance g. Using a filtered random matrix ensemble appropriate for describing coherent diffusion and the lateral spreading in an open geometry, we show analytically that M2/g appears as the controlling parameter in universal scaling laws for several statistical properties of interest--predictions that we quantitatively confirm with experimental data. Our work elucidates the roles of speckle correlations and provides a general theoretical framework for modeling open systems in wavefront-shaping experiments.

  1. Diagnostic criteria of chronic inflammatory demyelinating polyneuropathy in diabetes mellitus.

    PubMed

    Lotan, I; Hellman, M A; Steiner, I

    2015-10-01

    The possibility of co-association between diabetes mellitus (DM) and chronic inflammatory demyelinating polyneuropathy (CIDP) has long been a focus of interest as well as of clinical significance. As CIDP is a potentially treatable condition, it is diagnosis in the context of DM is of great importance. However, diagnostic criteria to identify CIDP in patients with diabetes are not available. We propose a diagnostic tool that should help clinicians to decide what is the probability that a patient with diabetes might have CIDP. We list several clinical, electrophysiological, and laboratory parameters that, when combined, have the power of discriminating an immune-mediated neuropathy in patients with DM. By summing the points assigned to each of these parameters, we define four levels of probability for a patient with diabetes to have CIDP. To analyze the validity of the diagnostic toll, we applied it in three different patient populations: (i) Patients with diabetes with peripheral neuropathy, (ii) Patients with CIDP without DM, and (iii) Patients with diabetes with CIDP. The scores of patients with diabetes without CIDP ranged from -7 to 2, while those of patients with DM-CIDP ranged from 2 to 20. The scores of non-diabetic patients with CIDP were similar to those of patients with DM-CIDP and ranged from 6 to 16. The mean score of patients with DM-CIDP was 9.083, while the score of patients with CIDP was 11.16 and that of patients with diabetic polyneuropathy was -3.59. These results show that this diagnostic tool is able to identify patients with diabetes with overlapping CIDP. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  2. Simple and ultra-fast recognition and quantitation of compounded monoclonal antibodies: Application to flow injection analysis combined to UV spectroscopy and matching method.

    PubMed

    Jaccoulet, E; Schweitzer-Chaput, A; Toussaint, B; Prognon, P; Caudron, E

    2018-09-01

    Compounding of monoclonal antibody (mAbs) constantly increases in hospital. Quality control (QC) of the compounded mAbs based on quantification and identification is required to prevent potential errors and fast method is needed to manage outpatient chemotherapy administration. A simple and ultra-fast (less than 30 s) method using flow injection analysis associated to least square matching method issued from the analyzer software was performed and evaluated for the routine hospital QC of three compounded mAbs: bevacizumab, infliximab and rituximab. The method was evaluated through qualitative and quantitative parameters. Preliminary analysis of the UV absorption and second derivative spectra of the mAbs allowed us to adapt analytical conditions according to the therapeutic range of the mAbs. In terms of quantitative QC, linearity, accuracy and precision were assessed as specified in ICH guidelines. Very satisfactory recovery was achieved and the RSD (%) of the intermediate precision were less than 1.1%. Qualitative analytical parameters were also evaluated in terms of specificity, sensitivity and global precision through a matrix of confusion. Results showed to be concentration and mAbs dependant and excellent (100%) specificity and sensitivity were reached within specific concentration range. Finally, routine application on "real life" samples (n = 209) from different batch of the three mAbs complied with the specifications of the quality control i.e. excellent identification (100%) and ± 15% of targeting concentration belonging to the calibration range. The successful use of the combination of second derivative spectroscopy and partial least square matching method demonstrated the interest of FIA for the ultra-fast QC of mAbs after compounding using matching method. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. Physicochemical and Functional Properties of Vegetable and Cereal Proteins as Potential Sources of Novel Food Ingredients

    PubMed Central

    Soria-Hernández, Cintya; Serna-Saldívar, Sergio

    2015-01-01

    Summary Proteins from vegetable and cereal sources are an excellent alternative to substitute animal-based counterparts because of their reduced cost, abundant supply and good nutritional value. The objective of this investigation is to study a set of vegetable and cereal proteins in terms of physicochemical and functional properties. Twenty protein sources were studied: five soya bean flour samples, one pea flour and fourteen newly developed blends of soya bean and maize germ (five concentrates and nine hydrolysates). The physicochemical characterization included pH (5.63 to 7.57), electrical conductivity (1.32 to 4.32 mS/cm), protein content (20.78 to 94.24% on dry mass basis), free amino nitrogen (0.54 to 2.87 mg/g) and urease activity (0.08 to 2.20). The functional properties showed interesting differences among proteins: water absorption index ranged from 0.41 to 18.52, the highest being of soya and maize concentrates. Nitrogen and water solubility ranged from 10.14 to 74.89% and from 20.42 to 95.65%, respectively. Fat absorption and emulsification activity indices ranged from 2.59 to 4.72 and from 3936.6 to 52 399.2 m2/g respectively, the highest being of pea flour. Foam activity (66.7 to 475.0%) of the soya and maize hydrolysates was the best. Correlation analyses showed that hydrolysis affected solubility-related parameters whereas fat-associated indices were inversely correlated with water-linked parameters. Foam properties were better of proteins treated with low heat, which also had high urease activity. Physicochemical and functional characterization of the soya and maize protein concentrates and hydrolysates allowed the identification of differences regarding other vegetable and cereal protein sources such as pea or soya bean. PMID:27904358

  4. Interest focuses on exploratory areas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stremel, K.

    1984-10-01

    Speculative geophysical programs are underway in sparsely drilled areas throughout the southern Rocky Mountain region. Responding to significant operator interest generated by new production in Nevada, a few contractors are designing programs to establish optimum recording parameters. Geophysical exploration activities in Colorado and Utah are discussed.

  5. Interactive model evaluation tool based on IPython notebook

    NASA Astrophysics Data System (ADS)

    Balemans, Sophie; Van Hoey, Stijn; Nopens, Ingmar; Seuntjes, Piet

    2015-04-01

    In hydrological modelling, some kind of parameter optimization is mostly performed. This can be the selection of a single best parameter set, a split in behavioural and non-behavioural parameter sets based on a selected threshold or a posterior parameter distribution derived with a formal Bayesian approach. The selection of the criterion to measure the goodness of fit (likelihood or any objective function) is an essential step in all of these methodologies and will affect the final selected parameter subset. Moreover, the discriminative power of the objective function is also dependent from the time period used. In practice, the optimization process is an iterative procedure. As such, in the course of the modelling process, an increasing amount of simulations is performed. However, the information carried by these simulation outputs is not always fully exploited. In this respect, we developed and present an interactive environment that enables the user to intuitively evaluate the model performance. The aim is to explore the parameter space graphically and to visualize the impact of the selected objective function on model behaviour. First, a set of model simulation results is loaded along with the corresponding parameter sets and a data set of the same variable as the model outcome (mostly discharge). The ranges of the loaded parameter sets define the parameter space. A selection of the two parameters visualised can be made by the user. Furthermore, an objective function and a time period of interest need to be selected. Based on this information, a two-dimensional parameter response surface is created, which actually just shows a scatter plot of the parameter combinations and assigns a color scale corresponding with the goodness of fit of each parameter combination. Finally, a slider is available to change the color mapping of the points. Actually, the slider provides a threshold to exclude non behaviour parameter sets and the color scale is only attributed to the remaining parameter sets. As such, by interactively changing the settings and interpreting the graph, the user gains insight in the model structural behaviour. Moreover, a more deliberate choice of objective function and periods of high information content can be identified. The environment is written in an IPython notebook and uses the available interactive functions provided by the IPython community. As such, the power of the IPython notebook as a development environment for scientific computing is illustrated (Shen, 2014).

  6. Microwave Moisture Sensing of Seedcotton: Part 1: Seedcotton Microwave Material Properties.

    PubMed

    Pelletier, Mathew G; Wanjura, John D; Holt, Greg A

    2016-11-02

    Moisture content at harvest is a key parameter that impacts quality and how well the cotton crop can be stored without degrading before processing. It is also a key parameter of interest for harvest time field trials as it can directly influence the quality of the harvested crop as well as skew the results of in-field yield and quality assessments. Microwave sensing of moisture has several unique advantages over lower frequency sensing approaches. The first is that microwaves are insensitive to variations in conductivity, due to presence of salts or minerals. The second advantage is that microwaves can peer deep inside large bulk packaging to assess the internal moisture content without performing a destructive tear down of the package. To help facilitate the development of a microwave moisture sensor for seedcotton; research was performed to determine the basic microwave properties of seedcotton. The research was performed on 110 kg micro-modules, which are of direct interest to research teams for use in ongoing field-based research projects. It should also prove useful for the enhancement of existing and future yield monitor designs. Experimental data was gathered on the basic relations between microwave material properties and seedcotton over the range from 1.0 GHz to 2.5 GHz and is reported on herein. This research is part one of a two-part series that reports on the fundamental microwave properties of seedcotton as moisture and density vary naturally during the course of typical harvesting operations; part two will utilize this data to formulate a prediction algorithm to form the basis for a prototype microwave moisture sensor.

  7. Microwave Moisture Sensing of Seedcotton: Part 1: Seedcotton Microwave Material Properties

    PubMed Central

    Pelletier, Mathew G.; Wanjura, John D.; Holt, Greg A.

    2016-01-01

    Moisture content at harvest is a key parameter that impacts quality and how well the cotton crop can be stored without degrading before processing. It is also a key parameter of interest for harvest time field trials as it can directly influence the quality of the harvested crop as well as skew the results of in-field yield and quality assessments. Microwave sensing of moisture has several unique advantages over lower frequency sensing approaches. The first is that microwaves are insensitive to variations in conductivity, due to presence of salts or minerals. The second advantage is that microwaves can peer deep inside large bulk packaging to assess the internal moisture content without performing a destructive tear down of the package. To help facilitate the development of a microwave moisture sensor for seedcotton; research was performed to determine the basic microwave properties of seedcotton. The research was performed on 110 kg micro-modules, which are of direct interest to research teams for use in ongoing field-based research projects. It should also prove useful for the enhancement of existing and future yield monitor designs. Experimental data was gathered on the basic relations between microwave material properties and seedcotton over the range from 1.0 GHz to 2.5 GHz and is reported on herein. This research is part one of a two-part series that reports on the fundamental microwave properties of seedcotton as moisture and density vary naturally during the course of typical harvesting operations; part two will utilize this data to formulate a prediction algorithm to form the basis for a prototype microwave moisture sensor. PMID:27827857

  8. Native characterization of nucleic acid motif thermodynamics via non-covalent catalysis

    PubMed Central

    Wang, Chunyan; Bae, Jin H.; Zhang, David Yu

    2016-01-01

    DNA hybridization thermodynamics is critical for accurate design of oligonucleotides for biotechnology and nanotechnology applications, but parameters currently in use are inaccurately extrapolated based on limited quantitative understanding of thermal behaviours. Here, we present a method to measure the ΔG° of DNA motifs at temperatures and buffer conditions of interest, with significantly better accuracy (6- to 14-fold lower s.e.) than prior methods. The equilibrium constant of a reaction with thermodynamics closely approximating that of a desired motif is numerically calculated from directly observed reactant and product equilibrium concentrations; a DNA catalyst is designed to accelerate equilibration. We measured the ΔG° of terminal fluorophores, single-nucleotide dangles and multinucleotide dangles, in temperatures ranging from 10 to 45 °C. PMID:26782977

  9. Testing and evaluation of the LES-6 pulsed plasma thruster by means of a torsion pendulum system

    NASA Technical Reports Server (NTRS)

    Hamidian, J. P.; Dahlgren, J. B.

    1973-01-01

    Performance characteristics of the LES-6 pulsed plasma thruster over a range of input conditions were investigated by means of a torsion pendulum system. Parameters of particular interest included the impulse bit and time average thrust (and their repeatability), specific impulse, mass ablated per discharge, specific thrust, energy per unit area, efficiency, and variation of performance with ignition command rate. Intermittency of the thruster as affected by input energy and igniter resistance were also investigated. Comparative experimental data correlation with the data presented. The results of these tests indicate that the LES-6 thruster, with some identifiable design improvements, represents an attractive reaction control thruster for attitude contol applications on long-life spacecraft requiring small metered impulse bits for precise pointing control of science instruments.

  10. Forecasting turning trends in knowledge networks

    NASA Astrophysics Data System (ADS)

    Szántó-Várnagy, Ádám; Farkas, Illés J.

    2018-10-01

    A large portion of our collective human knowledge is in electronic repositories. These repositories range from "hard fact" databases (e.g., scientific publications and patents) to "soft" knowledge such as news portals. The common denominator between them all is that they can be thought of in terms of topics/keywords. The interest in these topics is constantly changing over time. Their frequency occurrence diagrams can be used for effective prediction by the most straightforward simplification. In this paper, we use these diagrams to produce simple and human-readable rules that are able to predict the future trends of the most important keywords in 5 data sets of different types. A thorough analysis of the necessary input variables and parameters and their relation to the success rate is presented, as well.

  11. Biocompatible Polymer Nanoformulation To Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS.

    PubMed

    Ferrari, Raffaele; Talamini, Laura; Violatto, Martina Bruna; Giangregorio, Paola; Sponchioni, Mattia; Morbidelli, Massimo; Salmona, Mario; Bigini, Paolo; Moscatelli, Davide

    2017-01-03

    Fluorescent poly(ε-caprolactone)-based nanoparticles (NPs) have been synthesized and successfully loaded with a titanium organometallic compound as a mimic of a water-insoluble drug. The nature of this nanovector enabled us to combine the quantification of the metal in tissues after systemic administration in healthy immunocompetent mice by inductively coupled plasma mass spectroscopy (ICP-MS) followed by the visualization of NPs in organ sections by confocal microscopy. This innovative method of nanodrug screening has enabled us to elucidate the crucial parameters of their kinetics. The organometallic compound is a good mimic of most anticancer drugs, and this approach is an interesting starting point to design the relevance of a broad range of nanoformulations in terms of safety and targeted delivery of the cargoes.

  12. Small particle transport across turbulent nonisothermal boundary layers

    NASA Technical Reports Server (NTRS)

    Rosner, D. E.; Fernandez De La Mora, J.

    1982-01-01

    The interaction between turbulent diffusion, Brownian diffusion, and particle thermophoresis in the limit of vanishing particle inertial effects is quantitatively modeled for applications in gas turbines. The model is initiated with consideration of the particle phase mass conservation equation for a two-dimensional boundary layer, including the thermophoretic flux term directed toward the cold wall. A formalism of a turbulent flow near a flat plate in a heat transfer problem is adopted, and variable property effects are neglected. Attention is given to the limit of very large Schmidt numbers and the particle concentration depletion outside of the Brownian sublayer. It is concluded that, in the parameter range of interest, thermophoresis augments the high Schmidt number mass-transfer coefficient by a factor equal to the product of the outer sink and the thermophoretic suction.

  13. Generative Models of Segregation: Investigating Model-Generated Patterns of Residential Segregation by Ethnicity and Socioeconomic Status

    PubMed Central

    Fossett, Mark

    2011-01-01

    This paper considers the potential for using agent models to explore theories of residential segregation in urban areas. Results of generative experiments conducted using an agent-based simulation of segregation dynamics document that varying a small number of model parameters representing constructs from urban-ecological theories of segregation can generate a wide range of qualitatively distinct and substantively interesting segregation patterns. The results suggest how complex, macro-level patterns of residential segregation can arise from a small set of simple micro-level social dynamics operating within particular urban-demographic contexts. The promise and current limitations of agent simulation studies are noted and optimism is expressed regarding the potential for such studies to engage and contribute to the broader research literature on residential segregation. PMID:21379372

  14. Finite size scaling analysis on Nagel-Schreckenberg model for traffic flow

    NASA Astrophysics Data System (ADS)

    Balouchi, Ashkan; Browne, Dana

    2015-03-01

    The traffic flow problem as a many-particle non-equilibrium system has caught the interest of physicists for decades. Understanding the traffic flow properties and though obtaining the ability to control the transition from the free-flow phase to the jammed phase plays a critical role in the future world of urging self-driven cars technology. We have studied phase transitions in one-lane traffic flow through the mean velocity, distributions of car spacing, dynamic susceptibility and jam persistence -as candidates for an order parameter- using the Nagel-Schreckenberg model to simulate traffic flow. The length dependent transition has been observed for a range of maximum velocities greater than a certain value. Finite size scaling analysis indicates power-law scaling of these quantities at the onset of the jammed phase.

  15. Phase Separation of Superconducting Phases in the Penson-Kolb-Hubbard Model

    NASA Astrophysics Data System (ADS)

    Jerzy Kapcia, Konrad; Czart, Wojciech Robert; Ptok, Andrzej

    2016-04-01

    In this paper, we determine the phase diagrams (for T = 0 as well as T > 0) of the Penson-Kolb-Hubbard model for two dimensional square lattice within Hartree-Fock mean-field theory focusing on an investigation of superconducting phases and on a possibility of the occurrence of the phase separation. We obtain that the phase separation, which is a state of coexistence of two different superconducting phases (with s- and η-wave symmetries), occurs in definite ranges of the electron concentration. In addition, increasing temperature can change the symmetry of the superconducting order parameter (from η-wave into s-wave). The system considered exhibits also an interesting multicritical behaviour including bicritical points. The relevance of the results to experiments for real materials is also discussed.

  16. Hybrid Defect Phase Transition: Renormalization Group and Monte Carlo Analysis

    NASA Astrophysics Data System (ADS)

    Kaufman, Miron; Diep, H. T.

    2010-03-01

    For the q-state Potts model with 2 < q <= 4 on the square lattice with a defect line, the order parameter on the defect line jumps discontinuously from zero to a nonzero value while the defect energy varies continuously with the temperature at the critical temperature. Monte-Carlo simulations (H. T. Diep, M. Kaufman, Phys Rev E 2009) of the q-state Potts model on a square lattice with a line of defects verify the renormalization group prediction (M. Kaufman, R. B. Griffiths, Phys Rev B 1982) on the occurrence of the hybrid transition on the defect line. This is interesting since for those q values the bulk transition is continuous. This hybrid (continuous - discontinuous) defect transition is induced by the infinite range correlations at the bulk critical point.

  17. Born iterative reconstruction using perturbed-phase field estimates

    PubMed Central

    Astheimer, Jeffrey P.; Waag, Robert C.

    2008-01-01

    A method of image reconstruction from scattering measurements for use in ultrasonic imaging is presented. The method employs distorted-wave Born iteration but does not require using a forward-problem solver or solving large systems of equations. These calculations are avoided by limiting intermediate estimates of medium variations to smooth functions in which the propagated fields can be approximated by phase perturbations derived from variations in a geometric path along rays. The reconstruction itself is formed by a modification of the filtered-backpropagation formula that includes correction terms to account for propagation through an estimated background. Numerical studies that validate the method for parameter ranges of interest in medical applications are presented. The efficiency of this method offers the possibility of real-time imaging from scattering measurements. PMID:19062873

  18. HIS Design: Big Data that Supports Hydrologic Modeling from Continental to Hillslope Scales

    NASA Astrophysics Data System (ADS)

    Rasmussen, T. C.; Deemy, J. B.; Younger, S. E.; Kirk, S. E.; Brockman, L. E.

    2016-12-01

    Analogous to Google Maps, hydrologic data, information, and knowledge resolve differently depending upon the spatial and temporal scales of interest. We show how a multi-scale hydrologic information system (HIS) can be designed and populated for a broad range of spatial (e.g., hillslope, local, regional, continental) and temporal (e.g., current, recent, historic, geologic) scales. Surface and subsurface hydrologic and transport processes are assumed to be scale-dependent, requiring unique governing equations and parameters at each scale. This robust and flexible framework is designed to meet the inventory, monitoring, and management needs of multiple federal agencies (i.e., Forest Service, National Park Service, Fish and Wildlife Service, National Wildlife Reserves). Multi-scale HIS examples are provided using Geographic Information Systems (GIS) for the Southeastern US.

  19. Inexpensive, Open-Source, Internet of Things-Enabled Sensing Stations for Environmental Parameter Measurements

    NASA Astrophysics Data System (ADS)

    Marchetto, P. M.; Hofmeister, K.; Walter, M. T.

    2015-12-01

    In the age of the Internet, data is inherently portable. Given the shrinking numbers of stream gauges in the US under the banner of the USGS and the lack of collocation of sensors for environmental parameters, it is clear the only way to collect these data is with near real-time, multi-parameters sensing stations. We are designing a system that can be built and deployed for under $300 by community groups interested in learning more about the land that they are protecting, such as conservation groups, or groups interested in the basic science behind sensing and ecology, such as makerspaces. Sensing stations like these will enable a greater diversity of data collection while increasing public awareness of environmental issues and the research process.

  20. Closed-Loop Process Control for Electron Beam Freeform Fabrication and Deposition Processes

    NASA Technical Reports Server (NTRS)

    Taminger, Karen M. (Inventor); Hofmeister, William H. (Inventor); Martin, Richard E. (Inventor); Hafley, Robert A. (Inventor)

    2013-01-01

    A closed-loop control method for an electron beam freeform fabrication (EBF(sup 3)) process includes detecting a feature of interest during the process using a sensor(s), continuously evaluating the feature of interest to determine, in real time, a change occurring therein, and automatically modifying control parameters to control the EBF(sup 3) process. An apparatus provides closed-loop control method of the process, and includes an electron gun for generating an electron beam, a wire feeder for feeding a wire toward a substrate, wherein the wire is melted and progressively deposited in layers onto the substrate, a sensor(s), and a host machine. The sensor(s) measure the feature of interest during the process, and the host machine continuously evaluates the feature of interest to determine, in real time, a change occurring therein. The host machine automatically modifies control parameters to the EBF(sup 3) apparatus to control the EBF(sup 3) process in a closed-loop manner.

  1. Vision System for Coarsely Estimating Motion Parameters for Unknown Fast Moving Objects in Space

    PubMed Central

    Chen, Min; Hashimoto, Koichi

    2017-01-01

    Motivated by biological interests in analyzing navigation behaviors of flying animals, we attempt to build a system measuring their motion states. To do this, in this paper, we build a vision system to detect unknown fast moving objects within a given space, calculating their motion parameters represented by positions and poses. We proposed a novel method to detect reliable interest points from images of moving objects, which can be hardly detected by general purpose interest point detectors. 3D points reconstructed using these interest points are then grouped and maintained for detected objects, according to a careful schedule, considering appearance and perspective changes. In the estimation step, a method is introduced to adapt the robust estimation procedure used for dense point set to the case for sparse set, reducing the potential risk of greatly biased estimation. Experiments are conducted against real scenes, showing the capability of the system of detecting multiple unknown moving objects and estimating their positions and poses. PMID:29206189

  2. Towards Quantum Simulation with Circular Rydberg Atoms

    NASA Astrophysics Data System (ADS)

    Nguyen, T. L.; Raimond, J. M.; Sayrin, C.; Cortiñas, R.; Cantat-Moltrecht, T.; Assemat, F.; Dotsenko, I.; Gleyzes, S.; Haroche, S.; Roux, G.; Jolicoeur, Th.; Brune, M.

    2018-01-01

    The main objective of quantum simulation is an in-depth understanding of many-body physics, which is important for fundamental issues (quantum phase transitions, transport, …) and for the development of innovative materials. Analytic approaches to many-body systems are limited, and the huge size of their Hilbert space makes numerical simulations on classical computers intractable. A quantum simulator avoids these limitations by transcribing the system of interest into another, with the same dynamics but with interaction parameters under control and with experimental access to all relevant observables. Quantum simulation of spin systems is being explored with trapped ions, neutral atoms, and superconducting devices. We propose here a new paradigm for quantum simulation of spin-1 /2 arrays, providing unprecedented flexibility and allowing one to explore domains beyond the reach of other platforms. It is based on laser-trapped circular Rydberg atoms. Their long intrinsic lifetimes, combined with the inhibition of their microwave spontaneous emission and their low sensitivity to collisions and photoionization, make trapping lifetimes in the minute range realistic with state-of-the-art techniques. Ultracold defect-free circular atom chains can be prepared by a variant of the evaporative cooling method. This method also leads to the detection of arbitrary spin observables with single-site resolution. The proposed simulator realizes an X X Z spin-1 /2 Hamiltonian with nearest-neighbor couplings ranging from a few to tens of kilohertz. All the model parameters can be dynamically tuned at will, making a large range of simulations accessible. The system evolution can be followed over times in the range of seconds, long enough to be relevant for ground-state adiabatic preparation and for the study of thermalization, disorder, or Floquet time crystals. The proposed platform already presents unrivaled features for quantum simulation of regular spin chains. We discuss extensions towards more general quantum simulations of interacting spin systems with full control on individual interactions.

  3. The effect of heart motion on parameter bias in dynamic cardiac SPECT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ross, S.G.; Gullberg, G.T.; Huesman, R.H.

    1996-12-31

    Dynamic cardiac SPECT can be used to estimate kinetic rate parameters which describe the wash-in and wash-out of tracer activity between the blood and the myocardial tissue. These kinetic parameters can in turn be correlated to myocardial perfusion. There are, however, many physical aspects associated with dynamic SPECT which can introduce errors into the estimates. This paper describes a study which investigates the effect of heart motion on kinetic parameter estimates. Dynamic SPECT simulations are performed using a beating version of the MCAT phantom. The results demonstrate that cardiac motion has a significant effect on the blood, tissue, and backgroundmore » content of regions of interest. This in turn affects estimates of wash-in, while it has very little effect on estimates of wash-out. The effect of cardiac motion on parameter estimates appears not to be as great as effects introduced by photon noise and geometric collimator response. It is also shown that cardiac motion results in little extravascular contamination of the left ventricle blood region of interest.« less

  4. Bone texture analysis on dental radiographic images: results with several angulated radiographs on the same region of interest

    NASA Astrophysics Data System (ADS)

    Amouriq, Yves; Guedon, Jeanpierre; Normand, Nicolas; Arlicot, Aurore; Benhdech, Yassine; Weiss, Pierre

    2011-03-01

    Bone microarchitecture is the predictor of bone quality or bone disease. It can only be measured on a bone biopsy, which is invasive and not available for all clinical situations. Texture analysis on radiographs is a common way to investigate bone microarchitecture. But relationship between three-dimension histomorphometric parameters and two-dimension texture parameters is not always well known, with poor results. The aim of this study is to performed angulated radiographs of the same region of interest and see if a better relationship between texture analysis on several radiographs and histomorphometric parameters can be developed. Computed radiography images of dog (Beagle) mandible section in molar regions were compared with high-resolution micro-CT (Computed-Tomograph) volumes. Four radiographs with 27° angle (up, down, left, right, using Rinn ring and customized arm positioning system) were performed from initial radiograph position. Bone texture parameters were calculated on all images. Texture parameters were also computed from new images obtained by difference between angulated images. Results of fractal values in different trabecular areas give some caracterisation of bone microarchitecture.

  5. Multi-Response Parameter Interval Sensitivity and Optimization for the Composite Tape Winding Process.

    PubMed

    Deng, Bo; Shi, Yaoyao; Yu, Tao; Kang, Chao; Zhao, Pan

    2018-01-31

    The composite tape winding process, which utilizes a tape winding machine and prepreg tapes, provides a promising way to improve the quality of composite products. Nevertheless, the process parameters of composite tape winding have crucial effects on the tensile strength and void content, which are closely related to the performances of the winding products. In this article, two different object values of winding products, including mechanical performance (tensile strength) and a physical property (void content), were respectively calculated. Thereafter, the paper presents an integrated methodology by combining multi-parameter relative sensitivity analysis and single-parameter sensitivity analysis to obtain the optimal intervals of the composite tape winding process. First, the global multi-parameter sensitivity analysis method was applied to investigate the sensitivity of each parameter in the tape winding processing. Then, the local single-parameter sensitivity analysis method was employed to calculate the sensitivity of a single parameter within the corresponding range. Finally, the stability and instability ranges of each parameter were distinguished. Meanwhile, the authors optimized the process parameter ranges and provided comprehensive optimized intervals of the winding parameters. The verification test validated that the optimized intervals of the process parameters were reliable and stable for winding products manufacturing.

  6. Multi-Response Parameter Interval Sensitivity and Optimization for the Composite Tape Winding Process

    PubMed Central

    Yu, Tao; Kang, Chao; Zhao, Pan

    2018-01-01

    The composite tape winding process, which utilizes a tape winding machine and prepreg tapes, provides a promising way to improve the quality of composite products. Nevertheless, the process parameters of composite tape winding have crucial effects on the tensile strength and void content, which are closely related to the performances of the winding products. In this article, two different object values of winding products, including mechanical performance (tensile strength) and a physical property (void content), were respectively calculated. Thereafter, the paper presents an integrated methodology by combining multi-parameter relative sensitivity analysis and single-parameter sensitivity analysis to obtain the optimal intervals of the composite tape winding process. First, the global multi-parameter sensitivity analysis method was applied to investigate the sensitivity of each parameter in the tape winding processing. Then, the local single-parameter sensitivity analysis method was employed to calculate the sensitivity of a single parameter within the corresponding range. Finally, the stability and instability ranges of each parameter were distinguished. Meanwhile, the authors optimized the process parameter ranges and provided comprehensive optimized intervals of the winding parameters. The verification test validated that the optimized intervals of the process parameters were reliable and stable for winding products manufacturing. PMID:29385048

  7. Patients and Medical Statistics

    PubMed Central

    Woloshin, Steven; Schwartz, Lisa M; Welch, H Gilbert

    2005-01-01

    BACKGROUND People are increasingly presented with medical statistics. There are no existing measures to assess their level of interest or confidence in using medical statistics. OBJECTIVE To develop 2 new measures, the STAT-interest and STAT-confidence scales, and assess their reliability and validity. DESIGN Survey with retest after approximately 2 weeks. SUBJECTS Two hundred and twenty-four people were recruited from advertisements in local newspapers, an outpatient clinic waiting area, and a hospital open house. MEASURES We developed and revised 5 items on interest in medical statistics and 3 on confidence understanding statistics. RESULTS Study participants were mostly college graduates (52%); 25% had a high school education or less. The mean age was 53 (range 20 to 84) years. Most paid attention to medical statistics (6% paid no attention). The mean (SD) STAT-interest score was 68 (17) and ranged from 15 to 100. Confidence in using statistics was also high: the mean (SD) STAT-confidence score was 65 (19) and ranged from 11 to 100. STAT-interest and STAT-confidence scores were moderately correlated (r=.36, P<.001). Both scales demonstrated good test–retest repeatability (r=.60, .62, respectively), internal consistency reliability (Cronbach's α=0.70 and 0.78), and usability (individual item nonresponse ranged from 0% to 1.3%). Scale scores correlated only weakly with scores on a medical data interpretation test (r=.15 and .26, respectively). CONCLUSION The STAT-interest and STAT-confidence scales are usable and reliable. Interest and confidence were only weakly related to the ability to actually use data. PMID:16307623

  8. Theoretical and experimental studies in support of the geophysical fluid flow experiment

    NASA Technical Reports Server (NTRS)

    Hart, J.; Toomre, J.

    1985-01-01

    Meteorologists and astrophysicists interested in large scale planetary and solar circulations have come to recognize the importance of rotation and stratification in determining the character of these flows. In particular, the effect of latitude-dependent Coriolis force on nonlinear convection is thought to play a crucial role in such phenomena as differential rotation on the Sun, cloud band orientation on Jupiter, and the generation of magnetic fields in thermally driven dynamos. The continuous low-gravity environment of the orbiting space shuttle offers a unique opportunity to make laboratory studies of such large-scale thermally driven flows under the constraint imposed by rotation and sphericity. This is possible because polarization forces in a dielectric liquid, which are linearly dependent on fluid temperature, give rise to an effectively radial buoyancy force when a radial electrostatic field is imposed. The Geophysical Fluid Flow Cell (GFFC) is an implementation of this ideal in which fluid is contained between two rotating hemispheres that are differentially heated and stressed with a large a-c voltage. The experiment, to be flown on Spacelab III (currently set for launch April 29, 1985), will explore non-linear mode selection and high Rayleigh number turbulence in a rotating convecting spherical shell of liquid. Experiments will be carried out in a low driving parameter range where some limited numerical experimentation is currently feasible, as well as in a parameter range significantly beyond numerical computation for many years.

  9. An experimental investigation of the flap-lag-torsion aeroelastic stability of a small-scale hingeless helicopter rotor in hover

    NASA Technical Reports Server (NTRS)

    Sharpe, David L.

    1986-01-01

    A small scale, 1.92 m diam, torsionally soft, hingeless helicopter rotor was investigated in hover to determine isolated rotor stability characteristics. The two-bladed, untwisted rotor was tested on a rigid test stand at tip speeds up to 101 m/sec. The rotor mode of interest is the lightly damped lead-lag mode. The dimensionless lead-lag frequency of the mode is approximately 1.5 at the highest tip speed. The hub was designed to allow variation in precone, blade droop, pitch control stiffness, and blade pitch angle. Measurements of modal frequency and damping were obtained for several combinations of these hub parameters at several values of rotor speed. Steady blade bending moments were also measured. The lead-lag damping measurements were found to agree well with theoretical predictions for low values of blade pitch angle. The test data confirmed the predicted effects of precone, droop, and pitch control stiffness parameters on lead-lag damping. The correlation between theory and experiment was found to be poor for the mid-to-high range of pitch angles where the theory substantially overpredicted the experimental lead-lag damping. The poor correlation in the mid-to-high blade pitch angle range is attributed to low Reynolds number nonlinear aerodynamics effects not included in the theory. The experimental results also revealed an asymmetry in lead-lag damping between positive and negative thrust conditions.

  10. A Probabilistic Asteroid Impact Risk Model

    NASA Technical Reports Server (NTRS)

    Mathias, Donovan L.; Wheeler, Lorien F.; Dotson, Jessie L.

    2016-01-01

    Asteroid threat assessment requires the quantification of both the impact likelihood and resulting consequence across the range of possible events. This paper presents a probabilistic asteroid impact risk (PAIR) assessment model developed for this purpose. The model incorporates published impact frequency rates with state-of-the-art consequence assessment tools, applied within a Monte Carlo framework that generates sets of impact scenarios from uncertain parameter distributions. Explicit treatment of atmospheric entry is included to produce energy deposition rates that account for the effects of thermal ablation and object fragmentation. These energy deposition rates are used to model the resulting ground damage, and affected populations are computed for the sampled impact locations. The results for each scenario are aggregated into a distribution of potential outcomes that reflect the range of uncertain impact parameters, population densities, and strike probabilities. As an illustration of the utility of the PAIR model, the results are used to address the question of what minimum size asteroid constitutes a threat to the population. To answer this question, complete distributions of results are combined with a hypothetical risk tolerance posture to provide the minimum size, given sets of initial assumptions. Model outputs demonstrate how such questions can be answered and provide a means for interpreting the effect that input assumptions and uncertainty can have on final risk-based decisions. Model results can be used to prioritize investments to gain knowledge in critical areas or, conversely, to identify areas where additional data has little effect on the metrics of interest.

  11. 40 CFR 60.4410 - How do I establish a valid parameter range if I have chosen to continuously monitor parameters?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false How do I establish a valid parameter range if I have chosen to continuously monitor parameters? 60.4410 Section 60.4410 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of...

  12. [Impact of various millimeter-range electromagnetic radiation schedules on immunological parameters in patients with respiratory sarcoidosis].

    PubMed

    Borisov, S B; Shpykov, A S; Terent'eva, N A

    2007-01-01

    The paper analyzes the impact of various millimeter-range electromagnetic radiation schedules on immunological parameters in 152 patients with new-onset respiratory sarcoidosis. It shows that the immunomodulatory effect of millimeter-range therapy depends on the treatment regimen chosen. There is evidence for the advantages of millimeter-range noise electromagnetic radiation.

  13. Deriving amplification factors from simple site parameters using generalized regression neural networks: implications for relevant site proxies

    NASA Astrophysics Data System (ADS)

    Boudghene Stambouli, Ahmed; Zendagui, Djawad; Bard, Pierre-Yves; Derras, Boumédiène

    2017-07-01

    Most modern seismic codes account for site effects using an amplification factor (AF) that modifies the rock acceleration response spectra in relation to a "site condition proxy," i.e., a parameter related to the velocity profile at the site under consideration. Therefore, for practical purposes, it is interesting to identify the site parameters that best control the frequency-dependent shape of the AF. The goal of the present study is to provide a quantitative assessment of the performance of various site condition proxies to predict the main AF features, including the often used short- and mid-period amplification factors, Fa and Fv, proposed by Borcherdt (in Earthq Spectra 10:617-653, 1994). In this context, the linear, viscoelastic responses of a set of 858 actual soil columns from Japan, the USA, and Europe are computed for a set of 14 real accelerograms with varying frequency contents. The correlation between the corresponding site-specific average amplification factors and several site proxies (considered alone or as multiple combinations) is analyzed using the generalized regression neural network (GRNN). The performance of each site proxy combination is assessed through the variance reduction with respect to the initial amplification factor variability of the 858 profiles. Both the whole period range and specific short- and mid-period ranges associated with the Borcherdt factors Fa and Fv are considered. The actual amplification factor of an arbitrary soil profile is found to be satisfactorily approximated with a limited number of site proxies (4-6). As the usual code practice implies a lower number of site proxies (generally one, sometimes two), a sensitivity analysis is conducted to identify the "best performing" site parameters. The best one is the overall velocity contrast between underlying bedrock and minimum velocity in the soil column. Because these are the most difficult and expensive parameters to measure, especially for thick deposits, other more convenient parameters are preferred, especially the couple ( {V_{{{s}30}} ,f0 } ) that leads to a variance reduction in at least 60%. From a code perspective, equations and plots are provided describing the dependence of the short- and mid-period amplification factors Fa and Fv on these two parameters. The robustness of the results is analyzed by performing a similar analysis for two alternative sets of velocity profiles, for which the bedrock velocity is constrained to have the same value for all velocity profiles, which is not the case in the original set.[Figure not available: see fulltext.

  14. Semiparametric Estimation of the Impacts of Longitudinal Interventions on Adolescent Obesity using Targeted Maximum-Likelihood: Accessible Estimation with the ltmle Package

    PubMed Central

    Decker, Anna L.; Hubbard, Alan; Crespi, Catherine M.; Seto, Edmund Y.W.; Wang, May C.

    2015-01-01

    While child and adolescent obesity is a serious public health concern, few studies have utilized parameters based on the causal inference literature to examine the potential impacts of early intervention. The purpose of this analysis was to estimate the causal effects of early interventions to improve physical activity and diet during adolescence on body mass index (BMI), a measure of adiposity, using improved techniques. The most widespread statistical method in studies of child and adolescent obesity is multi-variable regression, with the parameter of interest being the coefficient on the variable of interest. This approach does not appropriately adjust for time-dependent confounding, and the modeling assumptions may not always be met. An alternative parameter to estimate is one motivated by the causal inference literature, which can be interpreted as the mean change in the outcome under interventions to set the exposure of interest. The underlying data-generating distribution, upon which the estimator is based, can be estimated via a parametric or semi-parametric approach. Using data from the National Heart, Lung, and Blood Institute Growth and Health Study, a 10-year prospective cohort study of adolescent girls, we estimated the longitudinal impact of physical activity and diet interventions on 10-year BMI z-scores via a parameter motivated by the causal inference literature, using both parametric and semi-parametric estimation approaches. The parameters of interest were estimated with a recently released R package, ltmle, for estimating means based upon general longitudinal treatment regimes. We found that early, sustained intervention on total calories had a greater impact than a physical activity intervention or non-sustained interventions. Multivariable linear regression yielded inflated effect estimates compared to estimates based on targeted maximum-likelihood estimation and data-adaptive super learning. Our analysis demonstrates that sophisticated, optimal semiparametric estimation of longitudinal treatment-specific means via ltmle provides an incredibly powerful, yet easy-to-use tool, removing impediments for putting theory into practice. PMID:26046009

  15. Range parameters of slow gold ions implanted into light targets

    NASA Astrophysics Data System (ADS)

    Kuzmin, V.

    2009-08-01

    Interatomic potentials for Au-C, Au-B, Au-N and Au-Si systems, calculated with density-functional theory (DFT) methods, have been used to evaluate the range parameters of gold in B, Si, BN and SiC films at energies of about 10-400 keV. The potentials have been employed to describe scattering angles of a projectile and to calculate the nuclear stopping powers and the higher moments of the energy, transferred in single collisions. Utilizing these findings the range parameters have been obtained by the standard transport theory and by Monte-Carlo simulations. A velocity proportional electronic stopping was included into the consideration. The approach developed corresponds completely to the standard classical scheme of the calculation of range parameters. Good agreement between the computed range parameters and available experimental data allow us to conclude that correlation effects between the nuclear and electronic stopping can be neglected in the energy range in question. Moreover, it is proven for the first time that the model by Grande, et al. [P.L. Grande, F.C. Zawislak, D. Fink, M. Behar, Nucl. Instr. and Meth. B 61 (1991) 282], which relies on the importance of correlation effects, contains inherent contradictions.

  16. Geoelectrohydraulic investigation of the surficial aquifer units and corrosivity in parts of Uyo L. G. A., Akwa Ibom State, Southern Nigeria

    NASA Astrophysics Data System (ADS)

    Ibuot, Johnson C.; Obiora, Daniel N.; Ekpa, Moses M. M.; Okoroh, Doris O.

    2017-12-01

    This study was carried out employing vertical electrical sounding (VES) with Schlumberger electrode configuration. The objectives were to investigate the distribution of the geohydraulic parameters and the corrosivity of the aquifer layer within the study area. The sand-to-coarse grain sands aquifer have resistivity ranging from 8.1 to 2204 Ωm, while the thickness ranged from 7.4 to 55.3 m. These parameters were used in computing the geohydraulic parameters. Hydraulic conductivity was estimated using the Heigold equation, and its values ranged from 1.42 to 54.90 m/day. Estimated hydraulic conductivity values were employed in determining the aquifer transmissivity which ranged from 11.28 to 812.00 m2/day, fractional porosities ranged from 0.0351 to 0.0598. The longitudinarl conductance also varies from 0.01 to 1.83 Ω-1. The contour plots generated from the SURFER software package show the variation of these parameters. The ranges of these estimated parameters indicate variation in grain sizes, magnitude of pore sizes and facies changes. The corrosivity rating indicates that most of the VES points were practically non-corrosive.

  17. Universal relations for range corrections to Efimov features

    DOE PAGES

    Ji, Chen; Braaten, Eric; Phillips, Daniel R.; ...

    2015-09-09

    In a three-body system of identical bosons interacting through a large S-wave scattering length a, there are several sets of features related to the Efimov effect that are characterized by discrete scale invariance. Effective field theory was recently used to derive universal relations between these Efimov features that include the first-order correction due to a nonzero effective range r s. We reveal a simple pattern in these range corrections that had not been previously identified. The pattern is explained by the renormalization group for the effective field theory, which implies that the Efimov three-body parameter runs logarithmically with the momentummore » scale at a rate proportional to r s/a. The running Efimov parameter also explains the empirical observation that range corrections can be largely taken into account by shifting the Efimov parameter by an adjustable parameter divided by a. Furthermore, the accuracy of universal relations that include first-order range corrections is verified by comparing them with various theoretical calculations using models with nonzero range.« less

  18. Optimal trace inequality constants for interior penalty discontinuous Galerkin discretisations of elliptic operators using arbitrary elements with non-constant Jacobians

    NASA Astrophysics Data System (ADS)

    Owens, A. R.; Kópházi, J.; Eaton, M. D.

    2017-12-01

    In this paper, a new method to numerically calculate the trace inequality constants, which arise in the calculation of penalty parameters for interior penalty discretisations of elliptic operators, is presented. These constants are provably optimal for the inequality of interest. As their calculation is based on the solution of a generalised eigenvalue problem involving the volumetric and face stiffness matrices, the method is applicable to any element type for which these matrices can be calculated, including standard finite elements and the non-uniform rational B-splines of isogeometric analysis. In particular, the presented method does not require the Jacobian of the element to be constant, and so can be applied to a much wider variety of element shapes than are currently available in the literature. Numerical results are presented for a variety of finite element and isogeometric cases. When the Jacobian is constant, it is demonstrated that the new method produces lower penalty parameters than existing methods in the literature in all cases, which translates directly into savings in the solution time of the resulting linear system. When the Jacobian is not constant, it is shown that the naive application of existing approaches can result in penalty parameters that do not guarantee coercivity of the bilinear form, and by extension, the stability of the solution. The method of manufactured solutions is applied to a model reaction-diffusion equation with a range of parameters, and it is found that using penalty parameters based on the new trace inequality constants result in better conditioned linear systems, which can be solved approximately 11% faster than those produced by the methods from the literature.

  19. Diurnal variation of oxygen and carbonate system parameters in Tampa Bay and Florida Bay

    USGS Publications Warehouse

    Yates, K.K.; Dufore, C.; Smiley, N.; Jackson, C.; Halley, R.B.

    2007-01-01

    Oxygen and carbonate system parameters were measured, in situ, over diurnal cycles in Tampa Bay and Florida Bay, Florida. All system parameters showed distinct diurnal trends in Tampa Bay with an average range of diurnal variation of 39.1 μmol kg− 1 for total alkalinity, 165.1 μmol kg− 1 for total CO2, 0.22 for pH, 0.093 mmol L− 1 for dissolved oxygen, and 218.1 μatm for pCO2. Average range of diurnal variation for system parameters in Tampa Bay was 73% to 93% of the seasonal range of variability for dissolved oxygen and pH. All system parameters measured in Florida Bay showed distinct variation over diurnal time-scales. However, clear diurnal trends were less evident. The average range of diurnal variability in Florida Bay was 62.8 μmol kg− 1 for total alkalinity, 130.4 μmol kg− 1 for total CO2, 0.13 for pH, 0.053 mmol L− 1 for dissolved oxygen, and 139.8 μatm for pCO2. The average range of diurnal variation was 14% to 102% of the seasonal ranges for these parameters. Diurnal variability in system parameters was most influenced by primary productivity and respiration of benthic communities in Tampa Bay, and by precipitation and dissolution of calcium carbonate in Florida Bay. Our data indicate that use of seasonal data sets without careful consideration of diurnal variability may impart significant error in calculations of annual carbon and oxygen budgets. These observations reinforce the need for higher temporal resolution measurements of oxygen and carbon system parameters in coastal ecosystems.

  20. NMR scalar couplings across Watson–Crick base pair hydrogen bonds in DNA observed by transverse relaxation-optimized spectroscopy

    PubMed Central

    Pervushin, Konstantin; Ono, Akira; Fernández, César; Szyperski, Thomas; Kainosho, Masatsune; Wüthrich, Kurt

    1998-01-01

    This paper describes the NMR observation of 15N—15N and 1H—15N scalar couplings across the hydrogen bonds in Watson–Crick base pairs in a DNA duplex, hJNN and hJHN. These couplings represent new parameters of interest for both structural studies of DNA and theoretical investigations into the nature of the hydrogen bonds. Two dimensional [15N,1H]-transverse relaxation-optimized spectroscopy (TROSY) with a 15N-labeled 14-mer DNA duplex was used to measure hJNN, which is in the range 6–7 Hz, and the two-dimensional hJNN-correlation-[15N,1H]-TROSY experiment was used to correlate the chemical shifts of pairs of hydrogen bond-related 15N spins and to observe, for the first time, hJHN scalar couplings, with values in the range 2–3.6 Hz. TROSY-based studies of scalar couplings across hydrogen bonds should be applicable for large molecular sizes, including protein-bound nucleic acids. PMID:9826668

  1. Frequency analysis of DC tolerant current transformers

    NASA Astrophysics Data System (ADS)

    Mlejnek, P.; Kaspar, P.

    2013-09-01

    This article deals with wide frequency range behaviour of DC tolerant current transformers that are usually used in modern static energy meters. In this application current transformers must comply with European and International Standards in their accuracy and DC tolerance. Therefore, the linear DC tolerant current transformers and double core current transformers are used in this field. More details about the problems of these particular types of transformers can be found in our previous works. Although these transformers are designed mainly for power distribution network frequency (50/60 Hz), it can be interesting to understand their behaviour in wider frequency range. Based on this knowledge the new generations of energy meters with measuring quality of electric energy will be produced. This solution brings better measurement of consumption of nonlinear loads or measurement of non-sinusoidal voltage and current sources such as solar cells or fuel cells. The determination of actual power consumption in such energy meters is done using particular harmonics component of current and voltage. We measured the phase and ratio errors that are the most important parameters of current transformers, to characterize several samples of current transformers of both types.

  2. Preparation of cellulose nanocrystals from asparagus (Asparagus officinalis L.) and their applications to palm oil/water Pickering emulsion.

    PubMed

    Wang, Wenhang; Du, Guanhua; Li, Cong; Zhang, Hongjie; Long, Yunduo; Ni, Yonghao

    2016-10-20

    Nano cellulosic materials as promising emulsion stabilizers have attracted great interest in food industry. In this paper, five different sized cellulose nanocrystals (CNC) samples were prepared from stem of Asparagus officinalis L. using the same sulfuric acid hydrolysis conditions but different times (1.5, 2, 2.5, 3.0, and 3.5h). The sizes of these CNC ranged from 178.2 to 261.8nm, with their crystallinity of 72.4-77.2%. The CNC aqueous dispersions showed a typical shear thinning behavior. In a palm oil/water (30/70, v/v) model solution, stable Pickering emulsions were formed with the addition of CNC, and their sizes are in the range of 1-10μm based on the optical and confocal laser scanning microscopy (CLSM) observation. The CNC sample prepared at 3h hydrolysis time, showed a relative efficient emulsion capacity for palm oil droplets, among these CNCs. Other parameters including the CNC, salt, and casein concentrations on the emulsion stability were studied. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Perspective: THz-driven nuclear dynamics from solids to molecules

    PubMed Central

    Hamm, Peter; Meuwly, Markus; Johnson, Steve L.; Beaud, Paul; Staub, Urs

    2017-01-01

    Recent years have seen dramatic developments in the technology of intense pulsed light sources in the THz frequency range. Since many dipole-active excitations in solids and molecules also lie in this range, there is now a tremendous potential to use these light sources to study linear and nonlinear dynamics in such systems. While several experimental investigations of THz-driven dynamics in solid-state systems have demonstrated a variety of interesting linear and nonlinear phenomena, comparatively few efforts have been made to drive analogous dynamics in molecular systems. In the present Perspective article, we discuss the similarities and differences between THz-driven dynamics in solid-state and molecular systems on both conceptual and practical levels. We also discuss the experimental parameters needed for these types of experiments and thereby provide design criteria for a further development of this new research branch. Finally, we present a few recent examples to illustrate the rich physics that may be learned from nonlinear THz excitations of phonons in solids as well as inter-molecular vibrations in liquid and gas-phase systems. PMID:29308420

  4. A lithium-ion capacitor model working on a wide temperature range

    NASA Astrophysics Data System (ADS)

    Barcellona, S.; Piegari, L.

    2017-02-01

    Energy storage systems are spreading both in stationary and transport applications. Among innovative storage devices, lithium ion capacitors (LiCs) are very interesting. They combine the advantages of both traditional electric double layer capacitors (EDLCs) and lithium ion batteries (LiBs). The behavior of this device is much more similar to ELDCs than to batteries. For this reason, several models developed for traditional ELDCs were extended to LiCs. Anyway, at low temperatures LiCs behavior is quite different from ELDCs and it is more similar to a LiB. Consequently, EDLC models works fine at room temperature but give worse results at low temperatures. This paper proposes a new electric model that, overcoming this issue, is a valid solution in a wide temperature range. Based on only five parameters, depending on polarization voltage and temperature, the proposed model is very simple to be implemented. Its accuracy is verified through experimental tests. From the reported results, it is also shown that, at very low temperatures, the dependence of the resistance from the current has to be taken into account.

  5. Perspective: THz-driven nuclear dynamics from solids to molecules.

    PubMed

    Hamm, Peter; Meuwly, Markus; Johnson, Steve L; Beaud, Paul; Staub, Urs

    2017-11-01

    Recent years have seen dramatic developments in the technology of intense pulsed light sources in the THz frequency range. Since many dipole-active excitations in solids and molecules also lie in this range, there is now a tremendous potential to use these light sources to study linear and nonlinear dynamics in such systems. While several experimental investigations of THz-driven dynamics in solid-state systems have demonstrated a variety of interesting linear and nonlinear phenomena, comparatively few efforts have been made to drive analogous dynamics in molecular systems. In the present Perspective article, we discuss the similarities and differences between THz-driven dynamics in solid-state and molecular systems on both conceptual and practical levels. We also discuss the experimental parameters needed for these types of experiments and thereby provide design criteria for a further development of this new research branch. Finally, we present a few recent examples to illustrate the rich physics that may be learned from nonlinear THz excitations of phonons in solids as well as inter-molecular vibrations in liquid and gas-phase systems.

  6. Fuel Cell Propulsion Systems for an All-electric Personal Air Vehicle

    NASA Technical Reports Server (NTRS)

    Kohout, Lisa L.; Schmitz, Paul C.

    2003-01-01

    There is a growing interest in the use of fuel cells as a power source for all-electric aircraft propulsion as a means to substantially reduce or eliminate environmentally harmful emissions. Among the technologies under consideration for these concepts are advanced proton exchange membrane and solid oxide fuel cells, alternative fuels and fuel processing, and fuel storage. This paper summarizes the results of a first-order feasibility study for an all-electric personal air vehicle utilizing a fuel cell-powered propulsion system. A representative aircraft with an internal combustion engine was chosen as a baseline to provide key parameters to the study, including engine power and subsystem mass, fuel storage volume and mass, and aircraft range. The engine, fuel tank, and associated ancillaries were then replaced with a fuel cell subsystem. Various configurations were considered including: a proton exchange membrane (PEM) fuel cell with liquid hydrogen storage; a direct methanol PEM fuel cell; and a direct internal reforming solid oxide fuel cell (SOFC)/turbine hybrid system using liquid methane fuel. Each configuration was compared to the baseline case on a mass and range basis.

  7. Fuel Cell Propulsion Systems for an All-Electric Personal Air Vehicle

    NASA Technical Reports Server (NTRS)

    Kohout, Lisa L.

    2003-01-01

    There is a growing interest in the use of fuel cells as a power source for all-electric aircraft propulsion as a means to substantially reduce or eliminate environmentally harmful emissions. Among the technologies under consideration for these concepts are advanced proton exchange membrane and solid oxide fuel cells, alternative fuels and fuel processing, and fuel storage. This paper summarizes the results of a first-order feasibility study for an all-electric personal air vehicle utilizing a fuel cell-powered propulsion system. A representative aircraft with an internal combustion engine was chosen as a baseline to provide key parameters to the study, including engine power and subsystem mass, fuel storage volume and mass, and aircraft range. The engine, fuel tank, and associated ancillaries were then replaced with a fuel cell subsystem. Various configurations were considered including: a proton exchange membrane (PEM) fuel cell with liquid hydrogen storage; a direct methanol PEM fuel cell; and a direct internal reforming solid oxide fuel cell (SOFC)/turbine hybrid system using liquid methane fuel. Each configuration was compared to the baseline case on a mass and range basis.

  8. Critical and post-critical behaviour of two-degree-of-freedom flutter-based generators

    NASA Astrophysics Data System (ADS)

    Pigolotti, Luca; Mannini, Claudio; Bartoli, Gianni; Thiele, Klaus

    2017-09-01

    Energy harvesting from flow-induced vibrations is a recent research field, which considers a diverse range of systems, among which two-degree-of-freedom flutter-based solutions were individuated as good candidates to obtain high energy performance. In the present work, numerical linear analyses and wind-tunnel tests were conducted on a flat-plate sectional model. The aim is to identify some design guidelines for generators exploiting the classical-flutter instability, through the investigation of the critical condition and the response during the post-critical regime. Many sets of governing parameters of interest from the energy-harvesting point of view were considered, including high levels of heaving damping to simulate the operation of a conversion apparatus. In particular, eccentricity of the elastic centre and small downstream mass unbalance can be introduced as solutions aiming at optimal operative ranges. The collected results suggest the high potentiality of flutter-based generators, and a significant enhancement of performance can be envisaged. Moreover, they contribute to improve the knowledge of the flutter excitation mechanism and to widen the dataset of measurements in the post-critical regime.

  9. Frame error rate for single-hop and dual-hop transmissions in 802.15.4 LoWPANs

    NASA Astrophysics Data System (ADS)

    Biswas, Sankalita; Ghosh, Biswajit; Chandra, Aniruddha; Dhar Roy, Sanjay

    2017-08-01

    IEEE 802.15.4 is a popular standard for personal area networks used in different low-rate short-range applications. This paper examines the error rate performance of 802.15.4 in fading wireless channel. An analytical model is formulated for evaluating frame error rate (FER); first, for direct single-hop transmission between two sensor nodes, and second, for dual-hop (DH) transmission using an in-between relay node. During modeling the transceiver design parameters are chosen according to the specifications set for both the 2.45 GHz and 868/915 MHz bands. We have also developed a simulation test bed for evaluating FER. Some results showed expected trends, such as FER is higher for larger payloads. Other observations are not that intuitive. It is interesting to note that the error rates are significantly higher for the DH case and demands a signal-to-noise ratio (SNR) penalty of about 7 dB. Also, the FER shoots from zero to one within a very small range of SNR.

  10. Quantitative tomographic imaging of intermolecular FRET in small animals

    PubMed Central

    Venugopal, Vivek; Chen, Jin; Barroso, Margarida; Intes, Xavier

    2012-01-01

    Forster resonance energy transfer (FRET) is a nonradiative transfer of energy between two fluorescent molecules (a donor and an acceptor) in nanometer range proximity. FRET imaging methods have been applied to proteomic studies and drug discovery applications based on intermolecular FRET efficiency measurements and stoichiometric measurements of FRET interaction as quantitative parameters of interest. Importantly, FRET provides information about biomolecular interactions at a molecular level, well beyond the diffraction limits of standard microscopy techniques. The application of FRET to small animal imaging will allow biomedical researchers to investigate physiological processes occurring at nanometer range in vivo as well as in situ. In this work a new method for the quantitative reconstruction of FRET measurements in small animals, incorporating a full-field tomographic acquisition system with a Monte Carlo based hierarchical reconstruction scheme, is described and validated in murine models. Our main objective is to estimate the relative concentration of two forms of donor species, i.e., a donor molecule involved in FRETing to an acceptor close by and a nonFRETing donor molecule. PMID:23243567

  11. Prediction of Welded Joint Strength in Plasma Arc Welding: A Comparative Study Using Back-Propagation and Radial Basis Neural Networks

    NASA Astrophysics Data System (ADS)

    Srinivas, Kadivendi; Vundavilli, Pandu R.; Manzoor Hussain, M.; Saiteja, M.

    2016-09-01

    Welding input parameters such as current, gas flow rate and torch angle play a significant role in determination of qualitative mechanical properties of weld joint. Traditionally, it is necessary to determine the weld input parameters for every new welded product to obtain a quality weld joint which is time consuming. In the present work, the effect of plasma arc welding parameters on mild steel was studied using a neural network approach. To obtain a response equation that governs the input-output relationships, conventional regression analysis was also performed. The experimental data was constructed based on Taguchi design and the training data required for neural networks were randomly generated, by varying the input variables within their respective ranges. The responses were calculated for each combination of input variables by using the response equations obtained through the conventional regression analysis. The performances in Levenberg-Marquardt back propagation neural network and radial basis neural network (RBNN) were compared on various randomly generated test cases, which are different from the training cases. From the results, it is interesting to note that for the above said test cases RBNN analysis gave improved training results compared to that of feed forward back propagation neural network analysis. Also, RBNN analysis proved a pattern of increasing performance as the data points moved away from the initial input values.

  12. Effect of rotation on fingering convection in stellar and planetary interiors

    NASA Astrophysics Data System (ADS)

    Sengupta, Sutirtha; Garaud, Pascale

    2018-01-01

    We study the effects of global rotation on the growth and saturation of the fingering (double-diffusive) instability at low Prandtl numbers and estimate the compositional transport rates as a function of the relevant non-dimensional parameters - the Taylor number, Ta^* (defined in terms of the rotation rate, Ω, thermal diffusivity κ_T and associated finger length scale d) and density ratio through direct numerical simulations. Within our explored range of parameters, we find rotation to have very little effect on vertical transport apart for an exceptional case where a cyclonic large scale vortex (LSV) is observed at low density ratio and fairly high Taylor number. The LSV leads to significant enhancement in the fingering transport rates by concentrating high composition fluid at its core which moves downward. The formation of such LSVs is of particular interest for solving the missing mixing problem in the astrophysical context of RGB stars though the parameter regime in which we observe the emergence of this LSV seems to be quite far from the stellar scenario. However, understanding the basic mechanism driving such large scale structures as observed frequently in polar regions of planets (e.g. those seen by Juno near the poles of Jupiter) is important in general for studies of rotating turbulence and its applications to stellar and planetary interior studies, and will be investigated in further detail in a forthcoming work.

  13. Neuropsychology, autobiographical memory, and hippocampal volume in "younger" and "older" patients with chronic schizophrenia.

    PubMed

    Herold, Christina Josefa; Lässer, Marc Montgomery; Schmid, Lena Anna; Seidl, Ulrich; Kong, Li; Fellhauer, Iven; Thomann, Philipp Arthur; Essig, Marco; Schröder, Johannes

    2015-01-01

    Despite a wide range of studies on neuropsychology in schizophrenia, autobiographical memory (AM) has been scarcely investigated in these patients. Hence, less is known about AM in older patients and hippocampal contribution to autobiographical memories of varying remoteness. Therefore, we investigated hippocampal volume and AM along with important neuropsychological domains in patients with chronic schizophrenia and the respective relationships between these parameters. We compared 25 older patients with chronic schizophrenia to 23 younger patients and an older healthy control group (N = 21) with respect to AM, additional neuropsychological parameters, and hippocampal volume. Personal episodic and semantic memory was investigated using a semi-structured interview. Additional neuropsychological parameters were assessed by using a battery of standard neuropsychological tests. Structural magnetic resonance imaging data were analyzed with an automated region-of-interest procedure. While hippocampal volume reduction and neuropsychological impairment were more pronounced in the older than in the younger patients, both groups showed equivalent reduced AM performance for recent personal episodes. In the patient group, significant correlations between left hippocampal volume and recent autobiographical episodes as well as personal semantic memories arose. Verbal memory and working memory were significantly correlated with right hippocampal volume; executive functions, however, were associated with bilateral hippocampal volumes. These findings underline the complexity of AM and its impairments in the course of schizophrenia in comparison to rather progressive neuropsychological deficits and address the importance of hippocampal contribution.

  14. Charge Density Waves and the Hidden Nesting of Purple Bronze KMo6O17

    NASA Astrophysics Data System (ADS)

    Su, Lei; Pereira, Vitor

    The layered purple bronze KMo6O17, with its robust triple CDW phase up to high temperatures, became the emblematic example of the ''hidden nesting'' concept. Recent experiments suggest that, on the surface layers, its CDW phase can be stabilized at much higher temperatures, and with a tenfold increase in the electronic gap in comparison with the bulk. Despite such interesting fermiology and properties, the K and Na purple bronzes remain largely unexplored systems, most particularly so at the theoretical level. We introduce the first multi-orbital effective tight-binding model to describe the effect of electron-electron interactions in this system. Upon fixing all the effective hopping parameters in the normal state against an ab-initio band structure, and with only the overall scale of the interactions as sole adjustable parameter, we find that a self-consistent Hartree-Fock solution reproduces extremely well the experimental behavior of the charge density wave (CDW) order parameter in the full range 0 < T < Tc , as well as the precise reciprocal space locations of the partial gap opening and Fermi arc development. The interaction strengths extracted from fitting to the experimental CDW gap are consistent with those derived from an independent Stoner-type analysis This work was supported by the Singapore National Research Foundation under Grant NRF-CRP6-2010-05.

  15. Solid-state NMR calculations for metal oxides and gallates: shielding and quadrupolar parameters for perovskites and related phases.

    PubMed

    Middlemiss, Derek S; Blanc, Frédéric; Pickard, Chris J; Grey, Clare P

    2010-05-01

    The NMR parameters obtained from solid-state DFT calculations within the GIPAW approach for (17)O- and (69/71)Ga-sites in a range of predominantly oxide-based (group II monoxides, SrTiO(3), BaZrO(3), BaSnO(3), BaTiO(3), LaAlO(3), LaGaO(3), SrZrO(3), MgSiO(3) and Ba(2)In(2)O(5)), and gallate (alpha- and beta-Ga(2)O(3), LiGaO(2), NaGaO(2), GaPO(4) and LaGaO(3)) materials are compared with experimental values, with a view to the future application of a similar approach to doped phases of interest as candidate intermediate temperature solid oxide fuel cell (ITSOFC) electrolytes. Isotropic and anisotropic chemical shift parameters, quadrupolar coupling constants, and associated asymmetries are presented and analyzed. The unusual GaO(5) site occurring in LaGaGe(2)O(7) is also fully characterised. In general, it is found that the theoretical results closely track the experimental trends, though some deviations are identified and discussed, particularly in regard to quadrupolar eta(Q)-values. The high quality of the computed results suggests that this approach can be extended to study more complex and disordered phases. Copyright 2010 Elsevier Inc. All rights reserved.

  16. Power law versus exponential state transition dynamics: application to sleep-wake architecture.

    PubMed

    Chu-Shore, Jesse; Westover, M Brandon; Bianchi, Matt T

    2010-12-02

    Despite the common experience that interrupted sleep has a negative impact on waking function, the features of human sleep-wake architecture that best distinguish sleep continuity versus fragmentation remain elusive. In this regard, there is growing interest in characterizing sleep architecture using models of the temporal dynamics of sleep-wake stage transitions. In humans and other mammals, the state transitions defining sleep and wake bout durations have been described with exponential and power law models, respectively. However, sleep-wake stage distributions are often complex, and distinguishing between exponential and power law processes is not always straightforward. Although mono-exponential distributions are distinct from power law distributions, multi-exponential distributions may in fact resemble power laws by appearing linear on a log-log plot. To characterize the parameters that may allow these distributions to mimic one another, we systematically fitted multi-exponential-generated distributions with a power law model, and power law-generated distributions with multi-exponential models. We used the Kolmogorov-Smirnov method to investigate goodness of fit for the "incorrect" model over a range of parameters. The "zone of mimicry" of parameters that increased the risk of mistakenly accepting power law fitting resembled empiric time constants obtained in human sleep and wake bout distributions. Recognizing this uncertainty in model distinction impacts interpretation of transition dynamics (self-organizing versus probabilistic), and the generation of predictive models for clinical classification of normal and pathological sleep architecture.

  17. Planes, trains, automobiles--and tea sets: extremely intense interests in very young children.

    PubMed

    DeLoache, Judy S; Simcock, Gabrielle; Macari, Suzanne

    2007-11-01

    Some normally developing young children show an intense, passionate interest in a particular category of objects or activities. The present article documents the existence of extremely intense interests that emerge very early in life and establishes some of the basic parameters of the phenomenon. Surveys and interviews with 177 parents revealed that nearly one third of young children have extremely intense interests. The nature of these intense interests is described, with particular focus on their emergence, commonalities in the content of the interests, and the reactions of other people to them. One of the most striking findings is a large gender difference: Extremely intense interests are much more common for young boys than for girls. (c) 2007 APA.

  18. Nonlinear information fusion algorithms for data-efficient multi-fidelity modelling.

    PubMed

    Perdikaris, P; Raissi, M; Damianou, A; Lawrence, N D; Karniadakis, G E

    2017-02-01

    Multi-fidelity modelling enables accurate inference of quantities of interest by synergistically combining realizations of low-cost/low-fidelity models with a small set of high-fidelity observations. This is particularly effective when the low- and high-fidelity models exhibit strong correlations, and can lead to significant computational gains over approaches that solely rely on high-fidelity models. However, in many cases of practical interest, low-fidelity models can only be well correlated to their high-fidelity counterparts for a specific range of input parameters, and potentially return wrong trends and erroneous predictions if probed outside of their validity regime. Here we put forth a probabilistic framework based on Gaussian process regression and nonlinear autoregressive schemes that is capable of learning complex nonlinear and space-dependent cross-correlations between models of variable fidelity, and can effectively safeguard against low-fidelity models that provide wrong trends. This introduces a new class of multi-fidelity information fusion algorithms that provide a fundamental extension to the existing linear autoregressive methodologies, while still maintaining the same algorithmic complexity and overall computational cost. The performance of the proposed methods is tested in several benchmark problems involving both synthetic and real multi-fidelity datasets from computational fluid dynamics simulations.

  19. Emotion Discrimination Using Spatially Compact Regions of Interest Extracted from Imaging EEG Activity

    PubMed Central

    Padilla-Buritica, Jorge I.; Martinez-Vargas, Juan D.; Castellanos-Dominguez, German

    2016-01-01

    Lately, research on computational models of emotion had been getting much attention due to their potential for understanding the mechanisms of emotions and their promising broad range of applications that potentially bridge the gap between human and machine interactions. We propose a new method for emotion classification that relies on features extracted from those active brain areas that are most likely related to emotions. To this end, we carry out the selection of spatially compact regions of interest that are computed using the brain neural activity reconstructed from Electroencephalography data. Throughout this study, we consider three representative feature extraction methods widely applied to emotion detection tasks, including Power spectral density, Wavelet, and Hjorth parameters. Further feature selection is carried out using principal component analysis. For validation purpose, these features are used to feed a support vector machine classifier that is trained under the leave-one-out cross-validation strategy. Obtained results on real affective data show that incorporation of the proposed training method in combination with the enhanced spatial resolution provided by the source estimation allows improving the performed accuracy of discrimination in most of the considered emotions, namely: dominance, valence, and liking. PMID:27489541

  20. Study of Pulsed vs. RF Plasma Properties for Surface Processing Applications

    NASA Astrophysics Data System (ADS)

    Tang, Ricky; Hopkins, Matthew; Barnat, Edward; Miller, Paul

    2015-09-01

    The ability to manipulate the plasma parameters (density, E/N) was previously demonstrated using a double-pulsed column discharge. Experiments extending this to large-surface plasmas of interest to the plasma processing community were conducted. Differences between an audio-frequency pulsed plasma and a radio-frequency (rf) discharge, both prevalent in plasma processing applications, were studied. Optical emission spectroscopy shows higher-intensity emission in the UV/visible range for the pulsed plasma comparing to the rf plasma at comparable powers. Data suggest that the electron energy is higher for the pulsed plasma leading to higher ionization, resulting in increased ion density and ion flux. Diode laser absorption measurements of the concentration of the 1S5 metastable and 1S4 resonance states of argon (correlated with the plasma E/N) provide comparisons between the excitation/ionization states of the two plasmas. Preliminary modeling efforts suggest that the low-frequency polarity switch causes a much more abrupt potential variation to support interesting transport phenomena, generating a ``wave'' of higher temperature electrons leading to more ionization, as well as ``sheath capture'' of a higher density bolus of ions that are then accelerated during polarity switch.

  1. Fresh-Cut Pineapple as a New Carrier of Probiotic Lactic Acid Bacteria

    PubMed Central

    Russo, Pasquale; de Chiara, Maria Lucia Valeria; Vernile, Anna; Amodio, Maria Luisa; Arena, Mattia Pia; Capozzi, Vittorio; Massa, Salvatore; Spano, Giuseppe

    2014-01-01

    Due to the increasing interest for healthy foods, the feasibility of using fresh-cut fruits to vehicle probiotic microorganisms is arising scientific interest. With this aim, the survival of probiotic lactic acid bacteria, belonging to Lactobacillus plantarum and Lactobacillus fermentum species, was monitored on artificially inoculated pineapple pieces throughout storage. The main nutritional, physicochemical, and sensorial parameters of minimally processed pineapples were monitored. Finally, probiotic Lactobacillus were further investigated for their antagonistic effect against Listeria monocytogenes and Escherichia coli O157:H7 on pineapple plugs. Our results show that at eight days of storage, the concentration of L. plantarum and L. fermentum on pineapples pieces ranged between 7.3 and 6.3 log cfu g−1, respectively, without affecting the final quality of the fresh-cut pineapple. The antagonistic assays indicated that L. plantarum was able to inhibit the growth of both pathogens, while L. fermentum was effective only against L. monocytogenes. This study suggests that both L. plantarum and L. fermentum could be successfully applied during processing of fresh-cut pineapples, contributing at the same time to inducing a protective effect against relevant foodborne pathogens. PMID:25093163

  2. Fast and effective characterization of 3D region of interest in medical image data

    NASA Astrophysics Data System (ADS)

    Kontos, Despina; Megalooikonomou, Vasileios

    2004-05-01

    We propose a framework for detecting, characterizing and classifying spatial Regions of Interest (ROIs) in medical images, such as tumors and lesions in MRI or activation regions in fMRI. A necessary step prior to classification is efficient extraction of discriminative features. For this purpose, we apply a characterization technique especially designed for spatial ROIs. The main idea of this technique is to extract a k-dimensional feature vector using concentric spheres in 3D (or circles in 2D) radiating out of the ROI's center of mass. These vectors form characterization signatures that can be used to represent the initial ROIs. We focus on classifying fMRI ROIs obtained from a study that explores neuroanatomical correlates of semantic processing in Alzheimer's disease (AD). We detect a ROI highly associated with AD and apply the feature extraction technique with different experimental settings. We seek to distinguish control from patient samples. We study how classification can be performed using the extracted signatures as well as how different experimental parameters affect classification accuracy. The obtained classification accuracy ranged from 82% to 87% (based on the selected ROI) suggesting that the proposed classification framework can be potentially useful in supporting medical decision-making.

  3. Near infrared (NIR) spectroscopy for in-line monitoring of polymer extrusion processes.

    PubMed

    Rohe, T; Becker, W; Kölle, S; Eisenreich, N; Eyerer, P

    1999-09-13

    In recent years, near infrared (NIR) spectroscopy has become an analytical tool frequently used in many chemical production processes. In particular, on-line measurements are of interest to increase process stability and to document constant product quality. Application to polymer processing e.g. polymer extrusion, could even increase product quality. Interesting parameters are composition of the processed polymer, moisture, or reaction status in reactive extrusion. For this issue a transmission sensor was developed for application of NIR spectroscopy to extrusion processes. This sensor includes fibre optic probes and a measuring cell to be adapted to various extruders for in-line measurements. In contrast to infrared sensors, it only uses optical quartz components. Extrusion processes at temperatures up to 300 degrees C and pressures up to 37 MPa have been investigated. Application of multivariate data analysis (e.g. partial least squares, PLS) demonstrated the performance of the system with respect to process monitoring: in the case of polymer blending, deviations between predicted and actual polymer composition were quite low (in the range of +/-0.25%). So the complete system is suitable for harsh industrial environments and could lead to improved polymer extrusion processes.

  4. Process-based soil erodibility estimation for empirical water erosion models

    USDA-ARS?s Scientific Manuscript database

    A variety of modeling technologies exist for water erosion prediction each with specific parameters. It is of interest to scrutinize parameters of a particular model from the point of their compatibility with dataset of other models. In this research, functional relationships between soil erodibilit...

  5. SDMProjectBuilder: SWAT Simulation and Calibration for Nutrient Fate and Transport

    EPA Science Inventory

    This tutorial reviews screens, icons, and basic functions for downloading flow, sediment, and nutrient observations for a watershed of interest; how to prepare SWAT-CUP input files for SWAT parameter calibration; and how to perform SWAT parameter calibration with SWAT-CUP. It dem...

  6. Swift Foxes and Ideal Free Distribution: Relative Influence of Vegetation and Rodent Prey Base on Swift Fox Survival, Density, and Home Range Size

    DTIC Science & Technology

    2012-01-01

    of exploiting a wide range of habitats, reported population parameters such as density and survival vary widely indicating variation in habitat quality...more strongly influenced by the “riskiness” of the habitat than by resource availability [8]. Swift fox population parameters in different landscapes...we explored the effects of landscape heterogeneity on population parameters likely to reflect habitat quality, such as population density, home range

  7. Scaling methane oxidation: From laboratory incubation experiments to landfill cover field conditions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abichou, Tarek, E-mail: abichou@eng.fsu.edu; Mahieu, Koenraad; Chanton, Jeff

    2011-05-15

    Evaluating field-scale methane oxidation in landfill cover soils using numerical models is gaining interest in the solid waste industry as research has made it clear that methane oxidation in the field is a complex function of climatic conditions, soil type, cover design, and incoming flux of landfill gas from the waste mass. Numerical models can account for these parameters as they change with time and space under field conditions. In this study, we developed temperature, and water content correction factors for methane oxidation parameters. We also introduced a possible correction to account for the different soil structure under field conditions.more » These parameters were defined in laboratory incubation experiments performed on homogenized soil specimens and were used to predict the actual methane oxidation rates to be expected under field conditions. Water content and temperature corrections factors were obtained for the methane oxidation rate parameter to be used when modeling methane oxidation in the field. To predict in situ measured rates of methane with the model it was necessary to set the half saturation constant of methane and oxygen, K{sub m}, to 5%, approximately five times larger than laboratory measured values. We hypothesize that this discrepancy reflects differences in soil structure between homogenized soil conditions in the lab and actual aggregated soil structure in the field. When all of these correction factors were re-introduced into the oxidation module of our model, it was able to reproduce surface emissions (as measured by static flux chambers) and percent oxidation (as measured by stable isotope techniques) within the range measured in the field.« less

  8. Uncertainty analysis of gross primary production partitioned from net ecosystem exchange measurements

    NASA Astrophysics Data System (ADS)

    Raj, Rahul; Hamm, Nicholas Alexander Samuel; van der Tol, Christiaan; Stein, Alfred

    2016-03-01

    Gross primary production (GPP) can be separated from flux tower measurements of net ecosystem exchange (NEE) of CO2. This is used increasingly to validate process-based simulators and remote-sensing-derived estimates of simulated GPP at various time steps. Proper validation includes the uncertainty associated with this separation. In this study, uncertainty assessment was done in a Bayesian framework. It was applied to data from the Speulderbos forest site, The Netherlands. We estimated the uncertainty in GPP at half-hourly time steps, using a non-rectangular hyperbola (NRH) model for its separation from the flux tower measurements. The NRH model provides a robust empirical relationship between radiation and GPP. It includes the degree of curvature of the light response curve, radiation and temperature. Parameters of the NRH model were fitted to the measured NEE data for every 10-day period during the growing season (April to October) in 2009. We defined the prior distribution of each NRH parameter and used Markov chain Monte Carlo (MCMC) simulation to estimate the uncertainty in the separated GPP from the posterior distribution at half-hourly time steps. This time series also allowed us to estimate the uncertainty at daily time steps. We compared the informative with the non-informative prior distributions of the NRH parameters and found that both choices produced similar posterior distributions of GPP. This will provide relevant and important information for the validation of process-based simulators in the future. Furthermore, the obtained posterior distributions of NEE and the NRH parameters are of interest for a range of applications.

  9. Evaluating Gaia performances on eclipsing binaries. IV. Orbits and stellar parameters for SV Cam, BS Dra and HP Dra

    NASA Astrophysics Data System (ADS)

    Milone, E. F.; Munari, U.; Marrese, P. M.; Williams, M. D.; Zwitter, T.; Kallrath, J.; Tomov, T.

    2005-10-01

    This is the fourth in a series of papers that aim both to provide reasonable orbits for a number of eclipsing binaries and to evaluate the expected performance of Gaia of these objects and the accuracy that is achievable in the determination of such fundamental stellar parameters as mass and radius. In this paper, we attempt to derive the orbits and physical parameters for three eclipsing binaries in the mid-F to mid-G spectral range. As for previous papers, only the H_P, V_T, BT photometry from the Hipparcos/Tycho mission and ground-based radial velocities from spectroscopy in the region 8480-8740 Å are used in the analyses. These data sets simulate the photometric and spectroscopic data that are expected to be obtained by Gaia, the approved ESA Cornerstone mission to be launched in 2011. The systems targeted in this paper are SV Cam, BS Dra and HP Dra. SV Cam and BS Dra have been studied previously, allowing comparisons of the derived parameters with those from full scale and devoted ground-based investigations. HP Dra has no published orbital solution. SV Cam has a β Lyrae type light curve and the others have Algol-like light curves. SV Cam has the complication of light curve anomalies, usually attributed to spots; BS Dra has non-solar metallicity, and HP Dra appears to have a small eccentricity and a sizeable time derivative in the argument of the periastron. Thus all three provide interesting and different test cases.

  10. The ecological niche of Dermacentor marginatus in Germany.

    PubMed

    Walter, Melanie; Brugger, Katharina; Rubel, Franz

    2016-06-01

    The ixodid tick Dermacentor marginatus (Sulzer, 1776) is endemic throughout southern Europe in the range of 33-51 (°) N latitude. In Germany, however, D. marginatus was exclusively reported in the Rhine valley and adjacent areas. Its northern distribution limit near Giessen is located at the coordinates 8.32 (°) E/50.65 (°) N. Particularly with regard to the causative agents of rickettsioses, tularemia, and Q fever, the observed locations as well as the potential distribution of the vector D. marginatus in Germany are of special interest. Applying a dataset of 118 georeferenced tick locations, the ecological niche for D. marginatus was calculated. It is described by six climate parameters based on temperature and relative humidity and another six environmental parameters including land cover classes and altitude. The final ecological niche is determined by the frequency distributions of these 12 parameters at the tick locations. Main parameters are the mean annual temperature (frequency distribution characterized by the minimum, median, and maximum of 6.1, 9.9, and 12.2 (°)C), the mean annual relative humidity (73.7, 76.7, and 80.9 %), as well as the altitude (87, 240, 1108 m). The climate and environmental niche is used to estimate the habitat suitability of D. marginatus in Germany by applying the BIOCLIM model. Finally, the potential spatial distribution of D. marginatus was calculated and mapped by determining an optimal threshold value of the suitability index, i.e., the maximum of sensitivity and specificity (Youden index). The model performance is expressed by AUC = 0.91.

  11. Beta Function Quintessence Cosmological Parameters and Fundamental Constants I: Power and Inverse Power Law Dark Energy Potentials

    NASA Astrophysics Data System (ADS)

    Thompson, Rodger I.

    2018-04-01

    This investigation explores using the beta function formalism to calculate analytic solutions for the observable parameters in rolling scalar field cosmologies. The beta function in this case is the derivative of the scalar ϕ with respect to the natural log of the scale factor a, β (φ )=d φ /d ln (a). Once the beta function is specified, modulo a boundary condition, the evolution of the scalar ϕ as a function of the scale factor is completely determined. A rolling scalar field cosmology is defined by its action which can contain a range of physically motivated dark energy potentials. The beta function is chosen so that the associated "beta potential" is an accurate, but not exact, representation of the appropriate dark energy model potential. The basic concept is that the action with the beta potential is so similar to the action with the model potential that solutions using the beta action are accurate representations of solutions using the model action. The beta function provides an extra equation to calculate analytic functions of the cosmologies parameters as a function of the scale factor that are that are not calculable using only the model action. As an example this investigation uses a quintessence cosmology to demonstrate the method for power and inverse power law dark energy potentials. An interesting result of the investigation is that the Hubble parameter H is almost completely insensitive to the power of the potentials and that ΛCDM is part of the family of quintessence cosmology power law potentials with a power of zero.

  12. Multicentre imaging measurements for oncology and in the brain

    PubMed Central

    Tofts, P S; Collins, D J

    2011-01-01

    Multicentre imaging studies of brain tumours (and other tumour and brain studies) can enable a large group of patients to be studied, yet they present challenging technical problems. Differences between centres can be characterised, understood and minimised by use of phantoms (test objects) and normal control subjects. Normal white matter forms an excellent standard for some MRI parameters (e.g. diffusion or magnetisation transfer) because the normal biological range is low (<2–3%) and the measurements will reflect this, provided the acquisition sequence is controlled. MR phantoms have benefits and they are necessary for some parameters (e.g. tumour volume). Techniques for temperature monitoring and control are given. In a multicentre study or treatment trial, between-centre variation should be minimised. In a cross-sectional study, all groups should be represented at each centre and the effect of centre added as a covariate in the statistical analysis. In a serial study of disease progression or treatment effect, individual patients should receive all of their scans at the same centre; the power is then limited by the within-subject reproducibility. Sources of variation that are generic to any imaging method and analysis parameters include MR sequence mismatch, B1 errors, CT effective tube potential, region of interest generation and segmentation procedure. Specific tissue parameters are analysed in detail to identify the major sources of variation and the most appropriate phantoms or normal studies. These include dynamic contrast-enhanced and dynamic susceptibility contrast gadolinium imaging, T1, diffusion, magnetisation transfer, spectroscopy, tumour volume, arterial spin labelling and CT perfusion. PMID:22433831

  13. Beta function quintessence cosmological parameters and fundamental constants - I. Power and inverse power law dark energy potentials

    NASA Astrophysics Data System (ADS)

    Thompson, Rodger I.

    2018-07-01

    This investigation explores using the beta function formalism to calculate analytic solutions for the observable parameters in rolling scalar field cosmologies. The beta function in this case is the derivative of the scalar φ with respect to the natural log of the scale factor a, β (φ)=d φ/d ln (a). Once the beta function is specified, modulo a boundary condition, the evolution of the scalar φ as a function of the scale factor is completely determined. A rolling scalar field cosmology is defined by its action which can contain a range of physically motivated dark energy potentials. The beta function is chosen so that the associated `beta potential' is an accurate, but not exact, representation of the appropriate dark energy model potential. The basic concept is that the action with the beta potential is so similar to the action with the model potential that solutions using the beta action are accurate representations of solutions using the model action. The beta function provides an extra equation to calculate analytic functions of the cosmologies parameters as a function of the scale factor that are not calculable using only the model action. As an example, this investigation uses a quintessence cosmology to demonstrate the method for power and inverse power law dark energy potentials. An interesting result of the investigation is that the Hubble parameter H is almost completely insensitive to the power of the potentials and that Λ cold dark matter is part of the family of quintessence cosmology power-law potentials with a power of zero.

  14. The relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions.

    PubMed

    Keppler, H; Degeest, S; Dhooge, I

    2017-11-01

    Chronic tinnitus is associated with reduced auditory input, which results in changes in the central auditory system. This study aimed to examine the relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. For audiometry, the parameters represented the edge frequency of hearing loss, the frequency of maximum hearing loss and the frequency range of hearing loss. For distortion product otoacoustic emissions, the parameters were the frequency of lowest distortion product otoacoustic emission amplitudes and the frequency range of reduced distortion product otoacoustic emissions. Sixty-seven patients (45 males, 22 females) with subjective chronic tinnitus, aged 18 to 73 years, were included. No correlation was found between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. However, tinnitus pitch fell mostly within the frequency range of hearing loss. The current study seems to confirm the relationship between tinnitus pitch and the frequency range of hearing loss, thus supporting the homeostatic plasticity model.

  15. Rapid Debris Analysis Project Task 3 Final Report - Sensitivity of Fallout to Source Parameters, Near-Detonation Environment Material Properties, Topography, and Meteorology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goldstein, Peter

    2014-01-24

    This report describes the sensitivity of predicted nuclear fallout to a variety of model input parameters, including yield, height of burst, particle and activity size distribution parameters, wind speed, wind direction, topography, and precipitation. We investigate sensitivity over a wide but plausible range of model input parameters. In addition, we investigate a specific example with a relatively narrow range to illustrate the potential for evaluating uncertainties in predictions when there are more precise constraints on model parameters.

  16. Global Sensitivity Applied to Dynamic Combined Finite Discrete Element Methods for Fracture Simulation

    NASA Astrophysics Data System (ADS)

    Godinez, H. C.; Rougier, E.; Osthus, D.; Srinivasan, G.

    2017-12-01

    Fracture propagation play a key role for a number of application of interest to the scientific community. From dynamic fracture processes like spall and fragmentation in metals and detection of gas flow in static fractures in rock and the subsurface, the dynamics of fracture propagation is important to various engineering and scientific disciplines. In this work we implement a global sensitivity analysis test to the Hybrid Optimization Software Suite (HOSS), a multi-physics software tool based on the combined finite-discrete element method, that is used to describe material deformation and failure (i.e., fracture and fragmentation) under a number of user-prescribed boundary conditions. We explore the sensitivity of HOSS for various model parameters that influence how fracture are propagated through a material of interest. The parameters control the softening curve that the model relies to determine fractures within each element in the mesh, as well a other internal parameters which influence fracture behavior. The sensitivity method we apply is the Fourier Amplitude Sensitivity Test (FAST), which is a global sensitivity method to explore how each parameter influence the model fracture and to determine the key model parameters that have the most impact on the model. We present several sensitivity experiments for different combination of model parameters and compare against experimental data for verification.

  17. Punctuation, Prosody, and Discourse: Afterthought Vs. Right Dislocation

    PubMed Central

    Kalbertodt, Janina; Primus, Beatrice; Schumacher, Petra B.

    2015-01-01

    In a reading production experiment we investigate the impact of punctuation and discourse structure on the prosodic differentiation of right dislocation (RD) and afterthought (AT). Both discourse structure and punctuation are likely to affect the prosodic marking of these right-peripheral constructions, as certain prosodic markings are appropriate only in certain discourse structures, and punctuation is said to correlate with prosodic phrasing. With RD and AT clearly differing in discourse function (comment-topic structuring vs. disambiguation) and punctuation (comma vs. full stop), critical items in this study were manipulated with regard to the (mis-)match of these parameters. Since RD and AT are said to prosodically differ in pitch range, phrasing, and accentuation patterns, we measured the reduction of pitch range, boundary strength and prominence level. Results show an effect of both punctuation and discourse context (mediated by syntax) on phrasing and accentuation. Interestingly, for pitch range reduction no difference between RDs and ATs could be observed. Our results corroborate a language architecture model in which punctuation, prosody, syntax, and discourse-semantics are independent but interacting domains with correspondence constraints between them. Our findings suggest there are tight correspondence constraints between (i) punctuation (full stop and comma in particular) and syntax, (ii) prosody and syntax as well as (iii) prosody and discourse-semantics. PMID:26648883

  18. Cd and proton adsorption onto bacterial consortia grown from industrial wastes and contaminated geologic settings.

    PubMed

    Borrok, David M; Fein, Jeremy B; Kulpa, Charles F

    2004-11-01

    To model the effects of bacterial metal adsorption in contaminated environments, results from metal adsorption experiments involving individual pure stains of bacteria must be extrapolated to systems in which potentially dozens of bacterial species are present. This extrapolation may be made easier because bacterial consortia from natural environments appear to exhibit similar metal binding properties. However, bacteria that thrive in highly perturbed contaminated environments may exhibit significantly different adsorptive behavior. Here we measure proton and Cd adsorption onto a range of bacterial consortia grown from heavily contaminated industrial wastes, groundwater, and soils. We model the results using a discrete site surface complexation approach to determine binding constants and site densities for each consortium. The results demonstrate that bacterial consortia from different contaminated environments exhibit a range of total site densities (approximately a 3-fold difference) and Cd-binding constants (approximately a 10-fold difference). These ranges for Cd binding constants may be small enough to suggest that bacteria-metal adsorption in contaminated environments can be described using relatively few "averaged" bacteria-metal binding constants (in conjunction with the necessary binding constants for competing surfaces and ligands). However, if additional precision is necessary, modeling parameters must be developed separately for each contaminated environment of interest.

  19. Dynamic alignment, tolerances, and metrology fundamentals at the nano and micro scales

    NASA Astrophysics Data System (ADS)

    Silberman, Donn M.

    2015-09-01

    Although the terms "micropositioning" and "nanopositioning" refer to different classes of positioning systems, "nanopositioning" is often used mistakenly to describe micropositioning systems. Micropositioning systems are typically motor-driven stages with travel ranges of a few millimeters up to a few hundred millimeters. Because the guiding systems in such stages — usually bearings of some kind — generate frictional forces, their resolution and repeatability are typically limited to 0.1 μm. The guiding system working principle also adds errors that are typically in the micrometer range. Nanopositioning systems are typically based on frictionless drives and guiding systems such as piezo actuators and flexures. These systems can achieve resolutions and guiding accuracies down to the sub-nanometer level. Both of these classes of precision positioning and motion systems are used extensively in precision optical and photonic systems to achieve desired performance specifications of instruments and experimental research projects. Currently, many precision positioning and motion systems have been design and implemented to cross over from the micro to the nano ranges with excellent results. This paper will describe some of the fundamental performance parameters and tolerances typical of these systems, some of the metrology used to confirm specifications and a few high end applications of general interest.

  20. A study on the effects of temperature and substrate structure on the templated two-phase film growth via a hybrid model

    NASA Astrophysics Data System (ADS)

    Lu, Xiao; Li, Jia; Zhu, Jian-Gang; Laughlin, David E.; Zhu, Jingxi

    2018-06-01

    Templated growth of two-phase thin films can achieve desirably ordered microstructures. In such cases, the microstructure of the growing films follows the topography of the template. By combining the Potts model Monte Carlo simulation and the "level set" method, an attempt was previously made to understand the physical mechanism behind the templated growth process. In the current work, this model is further used to study the effect of two parameters within the templated growth scenario, namely, the temperature and the geometric features of the template. The microstructure of the thin film grown with different lattice temperatures and domes is analyzed. It is found that within a moderate temperature range, the effect of geometric features took control of the ordering of the microstructure by its influence on the surface energy gradient. Interestingly, within this temperature range, as the temperature is increased, an ordered microstructure forms on a template without the optimal geometric features, which seems to be a result of competition between the kinetics and the thermodynamics during deposition. However, when the temperature was either above or below this temperature range, the template provided no guide to the whole deposition so that no ordered microstructure formed.

  1. A general framework for updating belief distributions.

    PubMed

    Bissiri, P G; Holmes, C C; Walker, S G

    2016-11-01

    We propose a framework for general Bayesian inference. We argue that a valid update of a prior belief distribution to a posterior can be made for parameters which are connected to observations through a loss function rather than the traditional likelihood function, which is recovered as a special case. Modern application areas make it increasingly challenging for Bayesians to attempt to model the true data-generating mechanism. For instance, when the object of interest is low dimensional, such as a mean or median, it is cumbersome to have to achieve this via a complete model for the whole data distribution. More importantly, there are settings where the parameter of interest does not directly index a family of density functions and thus the Bayesian approach to learning about such parameters is currently regarded as problematic. Our framework uses loss functions to connect information in the data to functionals of interest. The updating of beliefs then follows from a decision theoretic approach involving cumulative loss functions. Importantly, the procedure coincides with Bayesian updating when a true likelihood is known yet provides coherent subjective inference in much more general settings. Connections to other inference frameworks are highlighted.

  2. Meteorological Decision Assistance.

    DTIC Science & Technology

    1981-08-01

    500 for labor and materials. The most economical course of action can be determined by computing the cost/loss ratio (C/L) and comparing it to the...interest, a clima - tology of these parameters, the impact of these parameters on the customer’s mission, and the techniques for assessing the probability of

  3. Toward a Micro-Scale Acoustic Direction-Finding Sensor with Integrated Electronic Readout

    DTIC Science & Technology

    2013-06-01

    measurements with curve fits . . . . . . . . . . . . . . . 20 Figure 2.10 Failure testing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22...2.1 Sensor parameters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Table 2.2 Curve fit parameters...elastic, the quantity of interest is the elastic stiffness. In a typical nanoindentation test, the loading curve is nonlinear due to combined plastic

  4. USE OF CONTINUOUS MEASUREMENTS OF INTEGRAL AEROSOL PARAMETERS TO ESTIMATE PARTICLE SURFACE AREA

    EPA Science Inventory

    This study was undertaken because of interest in using particle surface area as an indicator for studies of the health effects of particulate matter. First, we wished to determine the integral parameter of the size distribution measured by the electrical aerosol detector. Secon...

  5. Associating an ionospheric parameter with major earthquake occurrence throughout the world

    NASA Astrophysics Data System (ADS)

    Ghosh, D.; Midya, S. K.

    2014-02-01

    With time, ionospheric variation analysis is gaining over lithospheric monitoring in serving precursors for earthquake forecast. The current paper highlights the association of major (Ms ≥ 6.0) and medium (4.0 ≤ Ms < 6.0) earthquake occurrences throughout the world in different ranges of the Ionospheric Earthquake Parameter (IEP) where `Ms' is earthquake magnitude on the Richter scale. From statistical and graphical analyses, it is concluded that the probability of earthquake occurrence is maximum when the defined parameter lies within the range of 0-75 (lower range). In the higher ranges, earthquake occurrence probability gradually decreases. A probable explanation is also suggested.

  6. Parameter Estimation for GRACE-FO Geometric Ranging Errors

    NASA Astrophysics Data System (ADS)

    Wegener, H.; Mueller, V.; Darbeheshti, N.; Naeimi, M.; Heinzel, G.

    2017-12-01

    Onboard GRACE-FO, the novel Laser Ranging Instrument (LRI) serves as a technology demonstrator, but it is a fully functional instrument to provide an additional high-precision measurement of the primary mission observable: the biased range between the two spacecraft. Its (expectedly) two largest error sources are laser frequency noise and tilt-to-length (TTL) coupling. While not much can be done about laser frequency noise, the mechanics of the TTL error are widely understood. They depend, however, on unknown parameters. In order to improve the quality of the ranging data, it is hence essential to accurately estimate these parameters and remove the resulting TTL error from the data.Means to do so will be discussed. In particular, the possibility of using calibration maneuvers, the utility of the attitude information provided by the LRI via Differential Wavefront Sensing (DWS), and the benefit from combining ranging data from LRI with ranging data from the established microwave ranging, will be mentioned.

  7. 77 FR 20399 - Notice of Interest Rate on Overdue Debts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Notice of Interest Rate on Overdue... CFR part 30) provides that the Secretary shall charge an annual rate of interest, which is [[Page... applicable rate determined from the ``Schedule of Certified Interest Rates with Range of Maturities'' unless...

  8. Sensitivity study for a remotely piloted microwave-powered sailplane used as a high-altitude observation

    NASA Technical Reports Server (NTRS)

    Turriziani, R. V.

    1979-01-01

    The sensitivity of several performance characteristics of a proposed design for a microwave-powered, remotely piloted, high-altitude sailplane to changes in independently varied design parameters was investigated. Results were expressed as variations from baseline values of range, final climb altitude and onboard storage of radiated energy. Calculated range decreased with increases in either gross weight or parasite drag coefficient; it also decreased with decreases in lift coefficient, propeller efficiency, or microwave beam density. The sensitivity trends for range and final climb altitude were very similar. The sensitivity trends for stored energy were reversed from those for range, except for decreasing microwave beam density. Some study results for single parameter variations were combined to estimate the effect of the simultaneous variation of several parameters: for two parameters, this appeared to give reasonably accurate results.

  9. Extensibility and limitations of FDDI

    NASA Technical Reports Server (NTRS)

    Game, David; Maly, Kurt J.

    1990-01-01

    Recently two standards for Metropolitan Area Networks (MANs), Fiber Distributed Data Interface (FDDI) and Distributed Queue Dual Bus (DQDB), have emerged as the primary competitors for the MAN arena. Great interest exists in building higher speed networks which support large numbers of node and greater distance, and it is not clear what types of protocols are needed for this type of environment. There is some question as to whether or not these MAN standards can be extended to such environments. The extensibility of FDDI to the Gbps range and a long distance environment is investigated. Specification parameters which affect performance are shown and a measure is provided for predicting utilization of FDDI. A comparison of FDDI at 100 Mbps and 1 Gbps is presented. Some specific problems with FDDI are addressed and modifications which improve the viability of FDDI in such high speed networks are investigated.

  10. Shape Memory Micro- and Nanowire Libraries for the High-Throughput Investigation of Scaling Effects.

    PubMed

    Oellers, Tobias; König, Dennis; Kostka, Aleksander; Xie, Shenqie; Brugger, Jürgen; Ludwig, Alfred

    2017-09-11

    The scaling behavior of Ti-Ni-Cu shape memory thin-film micro- and nanowires of different geometry is investigated with respect to its influence on the martensitic transformation properties. Two processes for the high-throughput fabrication of Ti-Ni-Cu micro- to nanoscale thin film wire libraries and the subsequent investigation of the transformation properties are reported. The libraries are fabricated with compositional and geometrical (wire width) variations to investigate the influence of these parameters on the transformation properties. Interesting behaviors were observed: Phase transformation temperatures change in the range from 1 to 72 °C (austenite finish, (A f ), 13 to 66 °C (martensite start, M s ) and the thermal hysteresis from -3.5 to 20 K. It is shown that a vanishing hysteresis can be achieved for special combinations of sample geometry and composition.

  11. The measurement of upward going muons using the MACRO detector.

    NASA Astrophysics Data System (ADS)

    Montaruli, T.

    1999-01-01

    The upward-going muon flux (Eμ > 1 GeV) has been measured with the underground detector MACRO at LNGS. The total number of measured events is compatible at the 8% c.l. with the expected one. Moreover, the zenith angular distribution of the measured flux does not match the expectation showing a deficit in the vertical direction where the apparatus performance is best known. Assuming an oscillation hypothesis with parameters in the range recently suggested to solve the atmospheric neutrino problem, the agreement increases, but not significantly. The results of an indirect dark matter search for a signal of WIMPs from the core of the Sun and of the Earth are given. Neutrino astronomy with MACRO is giving interesting results regarding possible high energy neutrino emission from pointlike sources and coincidences of neutrino events with γ-ray bursts.

  12. Fluorescent Dendritic Micro-Hydrogels: Synthesis, Analysis and Use in Single-Cell Detection.

    PubMed

    Christadore, Lisa; Grinstaff, Mark W; Schaus, Scott E

    2018-04-18

    Hydrogels are of keen interest for a wide range of medical and biotechnological applications including as 3D substrate structures for the detection of proteins, nucleic acids, and cells. Hydrogel parameters such as polymer wt % and crosslink density are typically altered for a specific application; now, fluorescence can be incorporated into such criteria by specific macromonomer selection. Intrinsic fluorescence was observed at λ max 445 nm from hydrogels polymerized from lysine and aldehyde- terminated poly(ethylene glycol) macromonomers upon excitation with visible light. The hydrogel’s photochemical properties are consistent with formation of a nitrone functionality. Printed hydrogels of 150 μm were used to detect individual cell adherence via a decreased in fluorescence. The use of such intrinsically fluorescent hydrogels as a platform for cell sorting and detection expands the current repertoire of tools available.

  13. Pair plasma relaxation time scales.

    PubMed

    Aksenov, A G; Ruffini, R; Vereshchagin, G V

    2010-04-01

    By numerically solving the relativistic Boltzmann equations, we compute the time scale for relaxation to thermal equilibrium for an optically thick electron-positron plasma with baryon loading. We focus on the time scales of electromagnetic interactions. The collisional integrals are obtained directly from the corresponding QED matrix elements. Thermalization time scales are computed for a wide range of values of both the total-energy density (over 10 orders of magnitude) and of the baryonic loading parameter (over 6 orders of magnitude). This also allows us to study such interesting limiting cases as the almost purely electron-positron plasma or electron-proton plasma as well as intermediate cases. These results appear to be important both for laboratory experiments aimed at generating optically thick pair plasmas as well as for astrophysical models in which electron-positron pair plasmas play a relevant role.

  14. Instability and dynamics of volatile thin films

    NASA Astrophysics Data System (ADS)

    Ji, Hangjie; Witelski, Thomas P.

    2018-02-01

    Volatile viscous fluids on partially wetting solid substrates can exhibit interesting interfacial instabilities and pattern formation. We study the dynamics of vapor condensation and fluid evaporation governed by a one-sided model in a low-Reynolds-number lubrication approximation incorporating surface tension, intermolecular effects, and evaporative fluxes. Parameter ranges for evaporation-dominated and condensation-dominated regimes and a critical case are identified. Interfacial instabilities driven by the competition between the disjoining pressure and evaporative effects are studied via linear stability analysis. Transient pattern formation in nearly flat evolving films in the critical case is investigated. In the weak evaporation limit unstable modes of finite-amplitude nonuniform steady states lead to rich droplet dynamics, including flattening, symmetry breaking, and droplet merging. Numerical simulations show that long-time behaviors leading to evaporation or condensation are sensitive to transitions between filmwise and dropwise dynamics.

  15. Laser induced nanostructures created from Au layer on polyhydroxybutyrate

    NASA Astrophysics Data System (ADS)

    Michaljaničová, I.; Slepička, P.; Juřík, P.; Švorčík, V.

    2017-11-01

    Nanostructures as well as composite materials expand the range of materials properties and allow use of these materials in new and highly specific applications. In this paper, we described laser modification of polyhydroxybutyrate films covered with thin gold layer, which led to the formation of various composite structures. The crucial for the composite structures creation was setting of appropriate laser parameters; 15 mJ cm-2 laser fluence and 6 000 pulses were recognized as the best. The morphology of structures was determined by the thickness of the Au layer. The most interesting formations, very porous with the biggest roughness, were observed after treatment of foils covered with 10 nm of Au. The morphology was observed by atomic force microscopy. The influence on roughness and the difference between projected area and surface area was also determined.

  16. Numerical difficulties associated with using equality constraints to achieve multi-level decomposition in structural optimization

    NASA Technical Reports Server (NTRS)

    Thareja, R.; Haftka, R. T.

    1986-01-01

    There has been recent interest in multidisciplinary multilevel optimization applied to large engineering systems. The usual approach is to divide the system into a hierarchy of subsystems with ever increasing detail in the analysis focus. Equality constraints are usually placed on various design quantities at every successive level to ensure consistency between levels. In many previous applications these equality constraints were eliminated by reducing the number of design variables. In complex systems this may not be possible and these equality constraints may have to be retained in the optimization process. In this paper the impact of such a retention is examined for a simple portal frame problem. It is shown that the equality constraints introduce numerical difficulties, and that the numerical solution becomes very sensitive to optimization parameters for a wide range of optimization algorithms.

  17. The Evolution of Latent Genes in Subdivided Populations

    PubMed Central

    Moody, M. E.; Basten, C. J.

    1990-01-01

    We define latent genes as phenotypically silent DNA sequences which may be reactivated by various genetic mechanisms. Of interest is how they and their functional counterparts can be maintained at high frequency in the face of mutation and selection pressure. We propose a two-deme, three-allele model incorporating viability selection, mutation and migration in haploid populations. It is shown that polymorphism for the three alleles can be easily maintained for a wide range of biologically meaningful parameter values. Computer simulations were employed to gain qualitative insight into the global dynamics of the system. It was found that the dynamics of the latent allele is closely correlated with that of the functional allele. In addition, bias in the migration rates can strengthen or weaken selective conditions for preservation of the functional and latent alleles. PMID:2307354

  18. Statistical Detection of Atypical Aircraft Flights

    NASA Technical Reports Server (NTRS)

    Statler, Irving; Chidester, Thomas; Shafto, Michael; Ferryman, Thomas; Amidan, Brett; Whitney, Paul; White, Amanda; Willse, Alan; Cooley, Scott; Jay, Joseph; hide

    2006-01-01

    A computational method and software to implement the method have been developed to sift through vast quantities of digital flight data to alert human analysts to aircraft flights that are statistically atypical in ways that signify that safety may be adversely affected. On a typical day, there are tens of thousands of flights in the United States and several times that number throughout the world. Depending on the specific aircraft design, the volume of data collected by sensors and flight recorders can range from a few dozen to several thousand parameters per second during a flight. Whereas these data have long been utilized in investigating crashes, the present method is oriented toward helping to prevent crashes by enabling routine monitoring of flight operations to identify portions of flights that may be of interest with respect to safety issues.

  19. Synchronous acceleration with tapered dielectric-lined waveguides

    NASA Astrophysics Data System (ADS)

    Lemery, F.; Floettmann, K.; Piot, P.; Kärtner, F. X.; Aßmann, R.

    2018-05-01

    We present a general concept to accelerate nonrelativistic charged particles. Our concept employs an adiabatically-tapered dielectric-lined waveguide which supports accelerating phase velocities for synchronous acceleration. We propose an ansatz for the transient field equations, show it satisfies Maxwell's equations under an adiabatic approximation and find excellent agreement with a finite-difference time-domain computer simulation. The fields were implemented into the particle-tracking program astra and we present beam dynamics results for an accelerating field with a 1-mm-wavelength and peak electric field of 100 MV /m . Numerical simulations indicate that a ˜200 -keV electron beam can be accelerated to an energy of ˜10 MeV over ˜10 cm with parameters of interest to a wide range of applications including, e.g., future advanced accelerators, and ultra-fast electron diffraction.

  20. Spin entanglement in elastic electron scattering from quasi-one electron atoms

    NASA Astrophysics Data System (ADS)

    Fonseca Dos Santos, Samantha; Bartschat, Klaus

    2017-04-01

    We have extended our work on e-Li collisions to investigate low-energy elastic electron collisions with atomic hydrogen and other alkali targets (Na,K,Rb). These systems have been suggested for the possibility of continuously varying the degree of entanglement between the elastically scattered projectile and the valence electron. In order to estimate how well such a scheme may work in practice, we carried out overview calculations for energies between 0 and 10 eV and the full range of scattering angles 0° -180° . In addition to the relative exchange asymmetry parameter that characterizes the entanglement, we present the differential cross section in order to estimate whether the count rates in the most interesting energy-angle regimes are sufficient to make such experiments feasible in practice. Work supported by the NSF under PHY-1403245.

  1. Effects of model definitions and parameter values in finite element modeling of human middle ear mechanics.

    PubMed

    De Greef, Daniel; Pires, Felipe; Dirckx, Joris J J

    2017-02-01

    Despite continuing advances in finite element software, the realistic simulation of middle ear response under acoustic stimulation continues to be challenging. One reason for this is the wide range of possible choices that can be made during the definition of a model. Therefore, an explorative study of the relative influences of some of these choices is potentially very helpful. Three finite element models of the human middle ear were constructed, based on high-resolution micro-computed tomography scans from three different human temporal bones. Interesting variations in modeling definitions and parameter values were selected and their influences on middle ear transmission were evaluated. The models were compared against different experimental validation criteria, both from the literature and from our own measurements. Simulation conditions were restricted to the frequency range 0.1-10 kHz. Modeling the three geometries with the same modeling definitions and parameters produces stapes footplate response curves that exhibit similar shapes, but quantitative differences of 4 dB in the lower frequencies and up to 6 dB around the resonance peaks. The model properties with the largest influences on our model outcomes are the tympanic membrane (TM) damping and stiffness and the cochlear load. Model changes with a small to negligible influence include the isotropy or orthotropy of the TM, the geometry of the connection between the TM and the malleus, the microstructure of the incudostapedial joint, and the length of the tensor tympani tendon. The presented results provide insights into the importance of different features in middle ear finite element modeling. The application of three different individual middle ear geometries in a single study reduces the possibility that the conclusions are strongly affected by geometrical abnormalities. Some modeling variations that were hypothesized to be influential turned out to be of minor importance. Furthermore, it could be confirmed that different geometries, simulated using the same parameters and definitions, can produce significantly different responses. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Demographic estimation methods for plants with unobservable life-states

    USGS Publications Warehouse

    Kery, M.; Gregg, K.B.; Schaub, M.

    2005-01-01

    Demographic estimation of vital parameters in plants with an unobservable dormant state is complicated, because time of death is not known. Conventional methods assume that death occurs at a particular time after a plant has last been seen aboveground but the consequences of assuming a particular duration of dormancy have never been tested. Capture-recapture methods do not make assumptions about time of death; however, problems with parameter estimability have not yet been resolved. To date, a critical comparative assessment of these methods is lacking. We analysed data from a 10 year study of Cleistes bifaria, a terrestrial orchid with frequent dormancy, and compared demographic estimates obtained by five varieties of the conventional methods, and two capture-recapture methods. All conventional methods produced spurious unity survival estimates for some years or for some states, and estimates of demographic rates sensitive to the time of death assumption. In contrast, capture-recapture methods are more parsimonious in terms of assumptions, are based on well founded theory and did not produce spurious estimates. In Cleistes, dormant episodes lasted for 1-4 years (mean 1.4, SD 0.74). The capture-recapture models estimated ramet survival rate at 0.86 (SE~ 0.01), ranging from 0.77-0.94 (SEs # 0.1) in anyone year. The average fraction dormant was estimated at 30% (SE 1.5), ranging 16 -47% (SEs # 5.1) in anyone year. Multistate capture-recapture models showed that survival rates were positively related to precipitation in the current year, but transition rates were more strongly related to precipitation in the previous than in the current year, with more ramets going dormant following dry years. Not all capture-recapture models of interest have estimable parameters; for instance, without excavating plants in years when they do not appear aboveground, it is not possible to obtain independent timespecific survival estimates for dormant plants. We introduce rigorous computer algebra methods to identify the parameters that are estimable in principle. As life-states are a prominent feature in plant life cycles, multi state capture-recapture models are a natural framework for analysing population dynamics of plants with dormancy.

  3. Free Energies of Quantum Particles: The Coupled-Perturbed Quantum Umbrella Sampling Method.

    PubMed

    Glover, William J; Casey, Jennifer R; Schwartz, Benjamin J

    2014-10-14

    We introduce a new simulation method called Coupled-Perturbed Quantum Umbrella Sampling that extends the classical umbrella sampling approach to reaction coordinates involving quantum mechanical degrees of freedom. The central idea in our method is to solve coupled-perturbed equations to find the response of the quantum system's wave function along a reaction coordinate of interest. This allows for propagation of the system's dynamics under the influence of a quantum biasing umbrella potential and provides a method to rigorously undo the effects of the bias to compute equilibrium ensemble averages. In this way, one can drag electrons into regions of high free energy where they would otherwise not go, thus enabling chemistry by fiat. We demonstrate the applicability of our method for two condensed-phase systems of interest. First, we consider the interaction of a hydrated electron with an aqueous sodium cation, and we calculate a potential of mean force that shows that an e(-):Na(+) contact pair is the thermodynamically favored product starting from either a neutral sodium atom or the separate cation and electron species. Second, we present the first determination of a hydrated electron's free-energy profile relative to an air/water interface. For the particular model parameters used, we find that the hydrated electron is more thermodynamically stable in the bulk rather than at the interface. Our analysis suggests that the primary driving force keeping the electron away from the interface is the long-range electron-solvent polarization interaction rather than the short-range details of the chosen pseudopotential.

  4. Inferring metabolic networks using the Bayesian adaptive graphical lasso with informative priors.

    PubMed

    Peterson, Christine; Vannucci, Marina; Karakas, Cemal; Choi, William; Ma, Lihua; Maletić-Savatić, Mirjana

    2013-10-01

    Metabolic processes are essential for cellular function and survival. We are interested in inferring a metabolic network in activated microglia, a major neuroimmune cell in the brain responsible for the neuroinflammation associated with neurological diseases, based on a set of quantified metabolites. To achieve this, we apply the Bayesian adaptive graphical lasso with informative priors that incorporate known relationships between covariates. To encourage sparsity, the Bayesian graphical lasso places double exponential priors on the off-diagonal entries of the precision matrix. The Bayesian adaptive graphical lasso allows each double exponential prior to have a unique shrinkage parameter. These shrinkage parameters share a common gamma hyperprior. We extend this model to create an informative prior structure by formulating tailored hyperpriors on the shrinkage parameters. By choosing parameter values for each hyperprior that shift probability mass toward zero for nodes that are close together in a reference network, we encourage edges between covariates with known relationships. This approach can improve the reliability of network inference when the sample size is small relative to the number of parameters to be estimated. When applied to the data on activated microglia, the inferred network includes both known relationships and associations of potential interest for further investigation.

  5. Inferring metabolic networks using the Bayesian adaptive graphical lasso with informative priors

    PubMed Central

    PETERSON, CHRISTINE; VANNUCCI, MARINA; KARAKAS, CEMAL; CHOI, WILLIAM; MA, LIHUA; MALETIĆ-SAVATIĆ, MIRJANA

    2014-01-01

    Metabolic processes are essential for cellular function and survival. We are interested in inferring a metabolic network in activated microglia, a major neuroimmune cell in the brain responsible for the neuroinflammation associated with neurological diseases, based on a set of quantified metabolites. To achieve this, we apply the Bayesian adaptive graphical lasso with informative priors that incorporate known relationships between covariates. To encourage sparsity, the Bayesian graphical lasso places double exponential priors on the off-diagonal entries of the precision matrix. The Bayesian adaptive graphical lasso allows each double exponential prior to have a unique shrinkage parameter. These shrinkage parameters share a common gamma hyperprior. We extend this model to create an informative prior structure by formulating tailored hyperpriors on the shrinkage parameters. By choosing parameter values for each hyperprior that shift probability mass toward zero for nodes that are close together in a reference network, we encourage edges between covariates with known relationships. This approach can improve the reliability of network inference when the sample size is small relative to the number of parameters to be estimated. When applied to the data on activated microglia, the inferred network includes both known relationships and associations of potential interest for further investigation. PMID:24533172

  6. Structural Physics of Bee Honeycomb

    NASA Astrophysics Data System (ADS)

    Kaatz, Forrest; Bultheel, Adhemar; Egami, Takeshi

    2008-03-01

    Honeybee combs have aroused interest in the ability of honeybees to form regular hexagonal geometric constructs since ancient times. Here we use a real space technique based on the pair distribution function (PDF) and radial distribution function (RDF), and a reciprocal space method utilizing the Debye-Waller Factor (DWF) to quantify the order for a range of honeycombs made by Apis mellifera. The PDFs and RDFs are fit with a series of Gaussian curves. We characterize the order in the honeycomb using a real space order parameter, OP3, to describe the order in the combs and a two-dimensional Fourier transform from which a Debye-Waller order parameter, u, is derived. Both OP3 and u take values from [0, 1] where the value one represents perfect order. The analyzed combs have values of OP3 from 0.33 to 0.60 and values of u from 0.83 to 0.98. RDF fits of honeycomb histograms show that naturally made comb can be crystalline in a 2D ordered structural sense, yet is more `liquid-like' than cells made on `foundation' wax. We show that with the assistance of man-made foundation wax, honeybees can manufacture highly ordered arrays of hexagonal cells.

  7. Infrared thermography quantitative image processing

    NASA Astrophysics Data System (ADS)

    Skouroliakou, A.; Kalatzis, I.; Kalyvas, N.; Grivas, TB

    2017-11-01

    Infrared thermography is an imaging technique that has the ability to provide a map of temperature distribution of an object’s surface. It is considered for a wide range of applications in medicine as well as in non-destructive testing procedures. One of its promising medical applications is in orthopaedics and diseases of the musculoskeletal system where temperature distribution of the body’s surface can contribute to the diagnosis and follow up of certain disorders. Although the thermographic image can give a fairly good visual estimation of distribution homogeneity and temperature pattern differences between two symmetric body parts, it is important to extract a quantitative measurement characterising temperature. Certain approaches use temperature of enantiomorphic anatomical points, or parameters extracted from a Region of Interest (ROI). A number of indices have been developed by researchers to that end. In this study a quantitative approach in thermographic image processing is attempted based on extracting different indices for symmetric ROIs on thermograms of the lower back area of scoliotic patients. The indices are based on first order statistical parameters describing temperature distribution. Analysis and comparison of these indices result in evaluating the temperature distribution pattern of the back trunk expected in healthy, regarding spinal problems, subjects.

  8. Simulated Wake Characteristics Data for Closely Spaced Parallel Runway Operations Analysis

    NASA Technical Reports Server (NTRS)

    Guerreiro, Nelson M.; Neitzke, Kurt W.

    2012-01-01

    A simulation experiment was performed to generate and compile wake characteristics data relevant to the evaluation and feasibility analysis of closely spaced parallel runway (CSPR) operational concepts. While the experiment in this work is not tailored to any particular operational concept, the generated data applies to the broader class of CSPR concepts, where a trailing aircraft on a CSPR approach is required to stay ahead of the wake vortices generated by a lead aircraft on an adjacent CSPR. Data for wake age, circulation strength, and wake altitude change, at various lateral offset distances from the wake-generating lead aircraft approach path were compiled for a set of nine aircraft spanning the full range of FAA and ICAO wake classifications. A total of 54 scenarios were simulated to generate data related to key parameters that determine wake behavior. Of particular interest are wake age characteristics that can be used to evaluate both time- and distance- based in-trail separation concepts for all aircraft wake-class combinations. A simple first-order difference model was developed to enable the computation of wake parameter estimates for aircraft models having weight, wingspan and speed characteristics similar to those of the nine aircraft modeled in this work.

  9. Emergence of jams in the generalized totally asymmetric simple exclusion process

    NASA Astrophysics Data System (ADS)

    Derbyshev, A. E.; Povolotsky, A. M.; Priezzhev, V. B.

    2015-02-01

    The generalized totally asymmetric exclusion process (TASEP) [J. Stat. Mech. (2012) P05014, 10.1088/1742-5468/2012/05/P05014] is an integrable generalization of the TASEP equipped with an interaction, which enhances the clustering of particles. The process interpolates between two extremal cases: the TASEP with parallel update and the process with all particles irreversibly merging into a single cluster moving as an isolated particle. We are interested in the large time behavior of this process on a ring in the whole range of the parameter λ controlling the interaction. We study the stationary state correlations, the cluster size distribution, and the large-time fluctuations of integrated particle current. When λ is finite, we find the usual TASEP-like behavior: The correlation length is finite; there are only clusters of finite size in the stationary state and current fluctuations belong to the Kardar-Parisi-Zhang universality class. When λ grows with the system size, so does the correlation length. We find a nontrivial transition regime with clusters of all sizes on the lattice. We identify a crossover parameter and derive the large deviation function for particle current, which interpolates between the case considered by Derrida-Lebowitz and a single-particle diffusion.

  10. Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets.

    PubMed

    Fonteyne, Margot; Wickström, Henrika; Peeters, Elisabeth; Vercruysse, Jurgen; Ehlers, Henrik; Peters, Björn-Hendrik; Remon, Jean Paul; Vervaet, Chris; Ketolainen, Jarkko; Sandler, Niklas; Rantanen, Jukka; Naelapää, Kaisa; De Beer, Thomas

    2014-07-01

    Continuous manufacturing gains more and more interest within the pharmaceutical industry. The International Conference of Harmonisation (ICH) states in its Q8 'Pharmaceutical Development' guideline that the manufacturer of pharmaceuticals should have an enhanced knowledge of the product performance over a range of raw material attributes, manufacturing process options and process parameters. This fits further into the Process Analytical Technology (PAT) and Quality by Design (QbD) framework. The present study evaluates the effect of variation in critical raw material properties on the critical quality attributes of granules and tablets, produced by a continuous from-powder-to-tablet wet granulation line. The granulation process parameters were kept constant to examine the differences in the end product quality caused by the variability of the raw materials properties only. Theophylline-Lactose-PVP (30-67.5-2.5%) was used as model formulation. Seven different grades of theophylline were granulated. Afterward, the obtained granules were tableted. Both the characteristics of granules and tablets were determined. The results show that differences in raw material properties both affect their processability and several critical quality attributes of the resulting granules and tablets. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. Using Satellite Data in Weather Forecasting: I

    NASA Technical Reports Server (NTRS)

    Jedlovec, Gary J.; Suggs, Ronnie J.; Lecue, Juan M.

    2006-01-01

    The GOES Product Generation System (GPGS) is a set of computer codes and scripts that enable the assimilation of real-time Geostationary Operational Environmental Satellite (GOES) data into regional-weather-forecasting mathematical models. The GPGS can be used to derive such geophysical parameters as land surface temperature, the amount of precipitable water, the degree of cloud cover, the surface albedo, and the amount of insolation from satellite measurements of radiant energy emitted by the Earth and its atmosphere. GPGS incorporates a priori information (initial guesses of thermodynamic parameters of the atmosphere) and radiometric measurements from the geostationary operational environmental satellites along with mathematical models of physical principles that govern the transfer of energy in the atmosphere. GPGS solves the radiative-transfer equation and provides the resulting data products in formats suitable for use by weather-forecasting computer programs. The data-assimilation capability afforded by GPGS offers the potential to improve local weather forecasts ranging from 3 hours to 2 days - especially with respect to temperature, humidity, cloud cover, and the probability of precipitation. The improvements afforded by GPGS could be of interest to news media, utility companies, and other organizations that utilize regional weather forecasts.

  12. Charge and current orders in the spin-fermion model with overlapping hot spots

    NASA Astrophysics Data System (ADS)

    Volkov, Pavel A.; Efetov, Konstantin B.

    2018-04-01

    Experiments carried over the last years on the underdoped cuprates have revealed a variety of symmetry-breaking phenomena in the pseudogap state. Charge-density waves, breaking of C4 rotational symmetry as well as time-reversal symmetry breaking have all been observed in several cuprate families. In this regard, theoretical models where multiple nonsuperconducting orders emerge are of particular interest. We consider the recently introduced [Volkov and Efetov, Phys. Rev. B 93, 085131 (2016), 10.1103/PhysRevB.93.085131] spin-fermion model with overlapping `hot spots' on the Fermi surface. Focusing on the particle-hole instabilities we obtain a rich phase diagram with the chemical potential relative to the dispersion at (0 ,π );(π ,0 ) and the Fermi surface curvature in the antinodal regions being the control parameters. We find evidence for d-wave Pomeranchuk instability, d-form factor charge density waves, as well as commensurate and incommensurate staggered bond current phases similar to the d-density wave state. The current orders are found to be promoted by the curvature. Considering the appropriate parameter range for the hole-doped cuprates, we discuss the relation of our results to the pseudogap state and incommensurate magnetic phases of the cuprates.

  13. Numerical study of heat transfer and fluid flow for steady crystal growth in a vertical Bridgman device

    NASA Astrophysics Data System (ADS)

    Pohlman, Matthew Michael

    The study of heat transfer and fluid flow in a vertical Bridgman device is motivated by current industrial difficulties in growing crystals with as few defects as possible. For example, Gallium Arsenide (GaAs) is of great interest to the semiconductor industry but remains an uneconomical alternative to silicon because of the manufacturing problems. This dissertation is a two dimensional study of the fluid in an idealized Bridgman device. The model nonlinear PDEs are discretized using second order finite differencing. Newton's method solves the resulting nonlinear discrete equations. The large sparse linear systems involving the Jacobian are solved iteratively using the Generalized Minimum Residual method (GMRES). By adapting fast direct solvers for elliptic equations with simple boundary conditions, a good preconditioner is developed which is essential for GMRES to converge quickly. Trends of the fluid flow and heat transfer for typical ranges of the physical parameters are determined. Also, the size of the terms in the mathematical model are found by numerical investigation, in order to find what terms are in balance as the physical parameters vary. The results suggest the plausibility of simpler asymptotic solutions.

  14. Automated Design Space Exploration with Aspen

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spafford, Kyle L.; Vetter, Jeffrey S.

    Architects and applications scientists often use performance models to explore a multidimensional design space of architectural characteristics, algorithm designs, and application parameters. With traditional performance modeling tools, these explorations forced users to first develop a performance model and then repeatedly evaluate and analyze the model manually. These manual investigations proved laborious and error prone. More importantly, the complexity of this traditional process often forced users to simplify their investigations. To address this challenge of design space exploration, we extend our Aspen (Abstract Scalable Performance Engineering Notation) language with three new language constructs: user-defined resources, parameter ranges, and a collection ofmore » costs in the abstract machine model. Then, we use these constructs to enable automated design space exploration via a nonlinear optimization solver. We show how four interesting classes of design space exploration scenarios can be derived from Aspen models and formulated as pure nonlinear programs. The analysis tools are demonstrated using examples based on Aspen models for a three-dimensional Fast Fourier Transform, the CoMD molecular dynamics proxy application, and the DARPA Streaming Sensor Challenge Problem. Our results show that this approach can compose and solve arbitrary performance modeling questions quickly and rigorously when compared to the traditional manual approach.« less

  15. Oscillatory slip flow past a spherical inclusion embedded in a Brinkman medium

    NASA Astrophysics Data System (ADS)

    Palaniappan, D.

    2016-11-01

    Non-steady flow past an impermeable sphere embedded in a porous medium is investigated based on Brinkman model with Navier slip conditions. Exact analytic solution for the stream-function - involving modified Bessel function of the second kind - describing the slow oscillatory flow around a rigid spherical inclusion is obtained in the limit of low-Reynolds-number. The key parameters such as the frequency of oscillation λ, the permeability constant δ, and the slip coefficient ξ control the flow fields and physical quantities in the entire flow domain. Local streamlines for fixed times demonstrate the variations in flow patterns. Closed form expressions for the tangential velocity profile, wall shear stress, and the force acting on the sphere are computed and compared with the existing results. It is noted that the slip parameter in the range 0 <= ξ <= 0 . 5 has a significant effect in reducing the stress and force. The steady-state velocity overshoot behavior in the vicinity of the sphere is re-iterated. In the limit of large permeability, Darcy (potential) flow is recovered outside a boundary layer. The results are of some interest in predicting maximum wall stress and pressure drop associated with biological models in fibrous media.

  16. A simplified lumped model for the optimization of post-buckled beam architecture wideband generator

    NASA Astrophysics Data System (ADS)

    Liu, Weiqun; Formosa, Fabien; Badel, Adrien; Hu, Guangdi

    2017-11-01

    Buckled beams structures are a classical kind of bistable energy harvesters which attract more and more interests because of their capability to scavenge energy over a large frequency band in comparison with linear generator. The usual modeling approach uses the Galerkin mode discretization method with relatively high complexity, while the simplification with a single-mode solution lacks accuracy. It stems on the optimization of the energy potential features to finally define the physical and geometrical parameters. Therefore, in this paper, a simple lumped model is proposed with explicit relationship between the potential shape and parameters to allow efficient design of bistable beams based generator. The accuracy of the approximation model is studied with the effectiveness of application analyzed. Moreover, an important fact, that the bending stiffness has little influence on the potential shape with low buckling level and the sectional area determined, is found. This feature extends the applicable range of the model by utilizing the design of high moment of inertia. Numerical investigations demonstrate that the proposed model is a simple and reliable tool for design. An optimization example of using the proposed model is demonstrated with satisfactory performance.

  17. Automated Design Space Exploration with Aspen

    DOE PAGES

    Spafford, Kyle L.; Vetter, Jeffrey S.

    2015-01-01

    Architects and applications scientists often use performance models to explore a multidimensional design space of architectural characteristics, algorithm designs, and application parameters. With traditional performance modeling tools, these explorations forced users to first develop a performance model and then repeatedly evaluate and analyze the model manually. These manual investigations proved laborious and error prone. More importantly, the complexity of this traditional process often forced users to simplify their investigations. To address this challenge of design space exploration, we extend our Aspen (Abstract Scalable Performance Engineering Notation) language with three new language constructs: user-defined resources, parameter ranges, and a collection ofmore » costs in the abstract machine model. Then, we use these constructs to enable automated design space exploration via a nonlinear optimization solver. We show how four interesting classes of design space exploration scenarios can be derived from Aspen models and formulated as pure nonlinear programs. The analysis tools are demonstrated using examples based on Aspen models for a three-dimensional Fast Fourier Transform, the CoMD molecular dynamics proxy application, and the DARPA Streaming Sensor Challenge Problem. Our results show that this approach can compose and solve arbitrary performance modeling questions quickly and rigorously when compared to the traditional manual approach.« less

  18. Insight in schizophrenia: a review.

    PubMed

    Dam, Jesper

    2006-01-01

    The issue of insight in schizophrenia must be assumed to be one of the most important aspects of the clinical examination. Comprehensive studies have shown that between 50% and 80% of all patients suffering from schizophrenia do not believe that they have a disorder. In recent years, poor insight in schizophrenia has been the subject of increasing interest, as manifested in a number of studies discussed in the present review. Some of these studies focus on insight correlated to various parameters such as psychopathology, neuropsychology, clinical relevance and compliance. Other studies refer to more theoretical implications, among these the issue of defining the concept of insight: whether insight can be seen as a "primary" phenomenon in schizophrenia, and whether insight may be graduated, dimensioned or increased. Several authors have developed rating scales in an attempt to obtain a measure for the degree or dimension of insight. Here, the range of parameters employed gives an excellent impression of the complexity of the concept of insight. In the concluding discussion, a phenomenological aspect is brought in, in an attempt to place the concept of insight in relation to disturbances of the self in schizophrenia and to primary symptoms in schizophrenia, amongst these autism.

  19. Sensor performance and weather effects modeling for intelligent transportation systems (ITS) applications

    NASA Astrophysics Data System (ADS)

    Everson, Jeffrey H.; Kopala, Edward W.; Lazofson, Laurence E.; Choe, Howard C.; Pomerleau, Dean A.

    1995-01-01

    Optical sensors are used for several ITS applications, including lateral control of vehicles, traffic sign recognition, car following, autonomous vehicle navigation, and obstacle detection. This paper treats the performance assessment of a sensor/image processor used as part of an on-board countermeasure system to prevent single vehicle roadway departure crashes. Sufficient image contrast between objects of interest and backgrounds is an essential factor influencing overall system performance. Contrast is determined by material properties affecting reflected/radiated intensities, as well as weather and visibility conditions. This paper discusses the modeling of these parameters and characterizes the contrast performance effects due to reduced visibility. The analysis process first involves generation of inherent road/off- road contrasts, followed by weather effects as a contrast modification. The sensor is modeled as a charge coupled device (CCD), with variable parameters. The results of the sensor/weather modeling are used to predict the performance on an in-vehicle warning system under various levels of adverse weather. Software employed in this effort was previously developed for the U.S. Air Force Wright Laboratory to determine target/background detection and recognition ranges for different sensor systems operating under various mission scenarios.

  20. An accurate potential model for the a3Σu+ state of the alkali dimers Na2, K2, Rb2, and Cs2

    NASA Astrophysics Data System (ADS)

    Lau, Jascha A.; Toennies, J. Peter; Tang, K. T.

    2016-11-01

    A modified semi-empirical Tang-Toennies potential model is used to describe the a3Σu+ potentials of the alkali dimers. These potentials are currently of interest in connection with the laser manipulation of the ultracold alkali gases. The fully analytical model is based on three experimental parameters, the well depth De, well location Re, and the harmonic vibrational frequency ωe of which the latter is only slightly optimized within the range of the literature values. Comparison with the latest spectroscopic data shows good agreement for Na2, K2, Rb2, and Cs2, comparable to that found with published potential models with up to 55 parameters. The differences between the reduced potential of Li2 and the conformal reduced potentials of the heavier dimers are analyzed together with why the model describes Li2 less accurately. The new model potential provides a test of the principle of corresponding states and an excellent first order approximation for further optimization to improve the fits to the spectroscopic data and describe the scattering lengths and Feshbach resonances at ultra-low temperatures.

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