Sample records for interface registration required

  1. SU-E-J-92: CERR: New Tools to Analyze Image Registration Precision.

    PubMed

    Apte, A; Wang, Y; Oh, J; Saleh, Z; Deasy, J

    2012-06-01

    To present new tools in CERR (The Computational Environment for Radiotherapy Research) to analyze image registration and other software updates/additions. CERR continues to be a key environment (cited more than 129 times to date) for numerous RT-research studies involving outcomes modeling, prototyping algorithms for segmentation, and registration, experiments with phantom dosimetry, IMRT research, etc. Image registration is one of the key technologies required in many research studies. CERR has been interfaced with popular image registration frameworks like Plastimatch and ITK. Once the images have been autoregistered, CERR provides tools to analyze the accuracy of registration using the following innovative approaches (1)Distance Discordance Histograms (DDH), described in detail in a separate paper and (2)'MirrorScope', explained as follows: for any view plane the 2-d image is broken up into a 2d grid of medium-sized squares. Each square contains a right-half, which is the reference image, and a left-half, which is the mirror flipped version of the overlay image. The user can increase or decrease the size of this grid to control the resolution of the analysis. Other updates to CERR include tools to extract image and dosimetric features programmatically and storage in a central database and tools to interface with Statistical analysis software like SPSS and Matlab Statistics toolbox. MirrorScope was compared on various examples, including 'perfect' registration examples and 'artificially translated' registrations. for 'perfect' registration, the patterns obtained within each circles are symmetric, and are easily, visually recognized as aligned. For registrations that are off, the patterns obtained in the circles located in the regions of imperfections show unsymmetrical patterns that are easily recognized. The new updates to CERR further increase its utility for RT-research. Mirrorscope is a visually intuitive method of monitoring the accuracy of image registration that improves on the visual confusion of standard methods. © 2012 American Association of Physicists in Medicine.

  2. Parallel image registration with a thin client interface

    NASA Astrophysics Data System (ADS)

    Saiprasad, Ganesh; Lo, Yi-Jung; Plishker, William; Lei, Peng; Ahmad, Tabassum; Shekhar, Raj

    2010-03-01

    Despite its high significance, the clinical utilization of image registration remains limited because of its lengthy execution time and a lack of easy access. The focus of this work was twofold. First, we accelerated our course-to-fine, volume subdivision-based image registration algorithm by a novel parallel implementation that maintains the accuracy of our uniprocessor implementation. Second, we developed a thin-client computing model with a user-friendly interface to perform rigid and nonrigid image registration. Our novel parallel computing model uses the message passing interface model on a 32-core cluster. The results show that, compared with the uniprocessor implementation, the parallel implementation of our image registration algorithm is approximately 5 times faster for rigid image registration and approximately 9 times faster for nonrigid registration for the images used. To test the viability of such systems for clinical use, we developed a thin client in the form of a plug-in in OsiriX, a well-known open source PACS workstation and DICOM viewer, and used it for two applications. The first application registered the baseline and follow-up MR brain images, whose subtraction was used to track progression of multiple sclerosis. The second application registered pretreatment PET and intratreatment CT of radiofrequency ablation patients to demonstrate a new capability of multimodality imaging guidance. The registration acceleration coupled with the remote implementation using a thin client should ultimately increase accuracy, speed, and access of image registration-based interpretations in a number of diagnostic and interventional applications.

  3. Reduction of accounts receivable through total quality management.

    PubMed

    LaFleur, N

    1994-01-01

    On October 1, 1990, The Miriam Hospital in Providence, R.I., converted to a new computer system for patient accounting applications and on-line registration functions. The new system automated the hospital's patient accounting, registration, and medical records functions and interfaced registration with patient accounts for billing purposes.

  4. A Matlab user interface for the statistically assisted fluid registration algorithm and tensor-based morphometry

    NASA Astrophysics Data System (ADS)

    Yepes-Calderon, Fernando; Brun, Caroline; Sant, Nishita; Thompson, Paul; Lepore, Natasha

    2015-01-01

    Tensor-Based Morphometry (TBM) is an increasingly popular method for group analysis of brain MRI data. The main steps in the analysis consist of a nonlinear registration to align each individual scan to a common space, and a subsequent statistical analysis to determine morphometric differences, or difference in fiber structure between groups. Recently, we implemented the Statistically-Assisted Fluid Registration Algorithm or SAFIRA,1 which is designed for tracking morphometric differences among populations. To this end, SAFIRA allows the inclusion of statistical priors extracted from the populations being studied as regularizers in the registration. This flexibility and degree of sophistication limit the tool to expert use, even more so considering that SAFIRA was initially implemented in command line mode. Here, we introduce a new, intuitive, easy to use, Matlab-based graphical user interface for SAFIRA's multivariate TBM. The interface also generates different choices for the TBM statistics, including both the traditional univariate statistics on the Jacobian matrix, and comparison of the full deformation tensors.2 This software will be freely disseminated to the neuroimaging research community.

  5. Strengthening of local vital events registration: lessons learnt from a voluntary sector initiative in a district in southern India.

    PubMed

    Mony, Prem; Sankar, Kiruba; Thomas, Tinku; Vaz, Mario

    2011-05-01

    Birth and death registration rates are low in most parts of India. Poor registration rates are due to constraints in both the government system (supply-side) and the general population (demand-side). We strengthened vital event registration at the local level within the existing legal framework by: (i) involving a non-profit organization as an interface between the government and the community; (ii) conducting supply-side interventions such as sensitization workshops for government officials, training for hospital staff and building data-sharing partnerships between stakeholders; (iii) monitoring for vital events by active surveillance through lay-informants; and (iv) conducting demand-side interventions such as publicity campaigns, education of families and assistance with registration. In the government sector, registration is given low priority and there is an attitude of blaming the victim, ascribing low levels of vital event registration to "cultural reasons/ignorance ". In the community, low registration was due to lack of awareness about the importance of and procedures for registration. This initiative helped improve registration of births and deaths at the subdistrict level. Vital event registration was significantly associated with local equity stratifiers such as gender, socioeconomic status and geography. The voluntary sector can interface effectively between the government and the community to strengthen vital registration. With political support from the government, outreach activities can dramatically improve vital event registration rates, especially in disadvantaged populations. The potential relevance of the data and the data collection process to stakeholders at the local level is a critical factor for success.

  6. Incorporating the whole-mount prostate histology reconstruction program Histostitcher into the extensible imaging platform (XIP) framework

    NASA Astrophysics Data System (ADS)

    Toth, Robert; Chappelow, Jonathan; Vetter, Christoph; Kutter, Oliver; Russ, Christoph; Feldman, Michael; Tomaszewski, John; Shih, Natalie; Madabhushi, Anant

    2012-03-01

    There is a need for identifying quantitative imaging (e.g. MRI) signatures for prostate cancer (CaP), so that computer-aided diagnostic methods can be trained to detect disease extent in vivo. Determining CaP extent on in vivo MRI is difficult to do; however, with the availability of ex vivo surgical whole mount histological sections (WMHS) for CaP patients undergoing radical prostatectomy, co-registration methods can be applied to align and map disease extent onto pre-operative MR imaging from the post-operative histology. Yet obtaining digitized images of WHMS for co-registration with the pre-operative MRI is cumbersome since (a) most digital slide scanners are unable to accommodate the entire section, and (b) significant technical expertise is required for whole mount slide preparation. Consequently, most centers opt to construct quartered sections of each histology slice. Prior to co-registration with MRI, however, these quartered sections need to be digitally stitched together to reconstitute a digital, pseudo WMHS. Histostitcheris an interactive software program that uses semi-automatic registration tools to digitally stitch quartered sections into pseudo WMHS. Histostitcherwas originally developed using the GUI tools provided by the Matlab programming interface, but the clinical use was limited due to the inefficiency of the interface. The limitations of the Matlab based GUI include (a) an inability to edit the fiducials, (b) the rendering being extremely slow, and (c) lack of interactive and rapid visualization tools. In this work, Histostitcherhas been integrated into the eXtensible Imaging Platform (XIP TM ) framework (a set of libraries containing functionalities for analyzing and visualizing medical image data). XIP TM lends the stitching tool much greater flexibility and functionality by (a) allowing interactive and seamless navigation through the full resolution histology images, (b) the ability to easily add, edit, or remove fiducials and annotations in order to register the quadrants and map the disease extent. In this work, we showcase examples of digital stitching of quartered histological sections into pseudo-WHMS using Histostitcher via the new XIP TM interface. This tool will be particularly useful in clinical trials and large cohort studies where a quick, interactive way of digitally reconstructing pseudo WMHS is required.

  7. Survey of Non-Rigid Registration Tools in Medicine.

    PubMed

    Keszei, András P; Berkels, Benjamin; Deserno, Thomas M

    2017-02-01

    We catalogue available software solutions for non-rigid image registration to support scientists in selecting suitable tools for specific medical registration purposes. Registration tools were identified using non-systematic search in Pubmed, Web of Science, IEEE Xplore® Digital Library, Google Scholar, and through references in identified sources (n = 22). Exclusions are due to unavailability or inappropriateness. The remaining (n = 18) tools were classified by (i) access and technology, (ii) interfaces and application, (iii) living community, (iv) supported file formats, and (v) types of registration methodologies emphasizing the similarity measures implemented. Out of the 18 tools, (i) 12 are open source, 8 are released under a permissive free license, which imposes the least restrictions on the use and further development of the tool, 8 provide graphical processing unit (GPU) support; (ii) 7 are built on software platforms, 5 were developed for brain image registration; (iii) 6 are under active development but only 3 have had their last update in 2015 or 2016; (iv) 16 support the Analyze format, while 7 file formats can be read with only one of the tools; and (v) 6 provide multiple registration methods and 6 provide landmark-based registration methods. Based on open source, licensing, GPU support, active community, several file formats, algorithms, and similarity measures, the tools Elastics and Plastimatch are chosen for the platform ITK and without platform requirements, respectively. Researchers in medical image analysis already have a large choice of registration tools freely available. However, the most recently published algorithms may not be included in the tools, yet.

  8. A Bayesian nonrigid registration method to enhance intraoperative target definition in image-guided prostate procedures through uncertainty characterization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pursley, Jennifer; Risholm, Petter; Fedorov, Andriy

    2012-11-15

    Purpose: This study introduces a probabilistic nonrigid registration method for use in image-guided prostate brachytherapy. Intraoperative imaging for prostate procedures, usually transrectal ultrasound (TRUS), is typically inferior to diagnostic-quality imaging of the pelvis such as endorectal magnetic resonance imaging (MRI). MR images contain superior detail of the prostate boundaries and provide substructure features not otherwise visible. Previous efforts to register diagnostic prostate images with the intraoperative coordinate system have been deterministic and did not offer a measure of the registration uncertainty. The authors developed a Bayesian registration method to estimate the posterior distribution on deformations and provide a case-specific measuremore » of the associated registration uncertainty. Methods: The authors adapted a biomechanical-based probabilistic nonrigid method to register diagnostic to intraoperative images by aligning a physician's segmentations of the prostate in the two images. The posterior distribution was characterized with a Markov Chain Monte Carlo method; the maximum a posteriori deformation and the associated uncertainty were estimated from the collection of deformation samples drawn from the posterior distribution. The authors validated the registration method using a dataset created from ten patients with MRI-guided prostate biopsies who had both diagnostic and intraprocedural 3 Tesla MRI scans. The accuracy and precision of the estimated posterior distribution on deformations were evaluated from two predictive distance distributions: between the deformed central zone-peripheral zone (CZ-PZ) interface and the physician-labeled interface, and based on physician-defined landmarks. Geometric margins on the registration of the prostate's peripheral zone were determined from the posterior predictive distance to the CZ-PZ interface separately for the base, mid-gland, and apical regions of the prostate. Results: The authors observed variation in the shape and volume of the segmented prostate in diagnostic and intraprocedural images. The probabilistic method allowed us to convey registration results in terms of posterior distributions, with the dispersion providing a patient-specific estimate of the registration uncertainty. The median of the predictive distance distribution between the deformed prostate boundary and the segmented boundary was Less-Than-Or-Slanted-Equal-To 3 mm (95th percentiles within {+-}4 mm) for all ten patients. The accuracy and precision of the internal deformation was evaluated by comparing the posterior predictive distance distribution for the CZ-PZ interface for each patient, with the median distance ranging from -0.6 to 2.4 mm. Posterior predictive distances between naturally occurring landmarks showed registration errors of Less-Than-Or-Slanted-Equal-To 5 mm in any direction. The uncertainty was not a global measure, but instead was local and varied throughout the registration region. Registration uncertainties were largest in the apical region of the prostate. Conclusions: Using a Bayesian nonrigid registration method, the authors determined the posterior distribution on deformations between diagnostic and intraprocedural MR images and quantified the uncertainty in the registration results. The feasibility of this approach was tested and results were positive. The probabilistic framework allows us to evaluate both patient-specific and location-specific estimates of the uncertainty in the registration result. Although the framework was tested on MR-guided procedures, the preliminary results suggest that it may be applied to TRUS-guided procedures as well, where the addition of diagnostic MR information may have a larger impact on target definition and clinical guidance.« less

  9. A Bayesian nonrigid registration method to enhance intraoperative target definition in image-guided prostate procedures through uncertainty characterization

    PubMed Central

    Pursley, Jennifer; Risholm, Petter; Fedorov, Andriy; Tuncali, Kemal; Fennessy, Fiona M.; Wells, William M.; Tempany, Clare M.; Cormack, Robert A.

    2012-01-01

    Purpose: This study introduces a probabilistic nonrigid registration method for use in image-guided prostate brachytherapy. Intraoperative imaging for prostate procedures, usually transrectal ultrasound (TRUS), is typically inferior to diagnostic-quality imaging of the pelvis such as endorectal magnetic resonance imaging (MRI). MR images contain superior detail of the prostate boundaries and provide substructure features not otherwise visible. Previous efforts to register diagnostic prostate images with the intraoperative coordinate system have been deterministic and did not offer a measure of the registration uncertainty. The authors developed a Bayesian registration method to estimate the posterior distribution on deformations and provide a case-specific measure of the associated registration uncertainty. Methods: The authors adapted a biomechanical-based probabilistic nonrigid method to register diagnostic to intraoperative images by aligning a physician's segmentations of the prostate in the two images. The posterior distribution was characterized with a Markov Chain Monte Carlo method; the maximum a posteriori deformation and the associated uncertainty were estimated from the collection of deformation samples drawn from the posterior distribution. The authors validated the registration method using a dataset created from ten patients with MRI-guided prostate biopsies who had both diagnostic and intraprocedural 3 Tesla MRI scans. The accuracy and precision of the estimated posterior distribution on deformations were evaluated from two predictive distance distributions: between the deformed central zone-peripheral zone (CZ-PZ) interface and the physician-labeled interface, and based on physician-defined landmarks. Geometric margins on the registration of the prostate's peripheral zone were determined from the posterior predictive distance to the CZ-PZ interface separately for the base, mid-gland, and apical regions of the prostate. Results: The authors observed variation in the shape and volume of the segmented prostate in diagnostic and intraprocedural images. The probabilistic method allowed us to convey registration results in terms of posterior distributions, with the dispersion providing a patient-specific estimate of the registration uncertainty. The median of the predictive distance distribution between the deformed prostate boundary and the segmented boundary was ⩽3 mm (95th percentiles within ±4 mm) for all ten patients. The accuracy and precision of the internal deformation was evaluated by comparing the posterior predictive distance distribution for the CZ-PZ interface for each patient, with the median distance ranging from −0.6 to 2.4 mm. Posterior predictive distances between naturally occurring landmarks showed registration errors of ⩽5 mm in any direction. The uncertainty was not a global measure, but instead was local and varied throughout the registration region. Registration uncertainties were largest in the apical region of the prostate. Conclusions: Using a Bayesian nonrigid registration method, the authors determined the posterior distribution on deformations between diagnostic and intraprocedural MR images and quantified the uncertainty in the registration results. The feasibility of this approach was tested and results were positive. The probabilistic framework allows us to evaluate both patient-specific and location-specific estimates of the uncertainty in the registration result. Although the framework was tested on MR-guided procedures, the preliminary results suggest that it may be applied to TRUS-guided procedures as well, where the addition of diagnostic MR information may have a larger impact on target definition and clinical guidance. PMID:23127078

  10. 78 FR 12322 - Agency Information Collection Activities: OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... Interchange (EDI) Registration and Electronic Data Interchange (EDI) Enrollment Form; Use: The purpose of this... identification of Medicare providers/suppliers and authorization of requested Electronic Data Interface (EDI) functions. The EDI Enrollment and the Medicare Registration Forms are completed by Medicare providers...

  11. 16 CFR 1130.8 - Requirements for Web site registration or alternative e-mail registration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Requirements for Web site registration or... PRODUCTS § 1130.8 Requirements for Web site registration or alternative e-mail registration. (a) Link to registration page. The manufacturer's Web site, or other Web site established for the purpose of registration...

  12. 16 CFR 1130.8 - Requirements for Web site registration or alternative e-mail registration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Requirements for Web site registration or... PRODUCTS § 1130.8 Requirements for Web site registration or alternative e-mail registration. (a) Link to registration page. The manufacturer's Web site, or other Web site established for the purpose of registration...

  13. 16 CFR 1130.7 - Requirements for Web site registration or alternative e-mail registration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Requirements for Web site registration or... PRODUCTS § 1130.7 Requirements for Web site registration or alternative e-mail registration. (a) Link to registration page. The manufacturer's Web site, or other Web site established for the purpose of registration...

  14. Registration of organs with sliding interfaces and changing topologies

    NASA Astrophysics Data System (ADS)

    Berendsen, Floris F.; Kotte, Alexis N. T. J.; Viergever, Max A.; Pluim, Josien P. W.

    2014-03-01

    Smoothness and continuity assumptions on the deformation field in deformable image registration do not hold for applications where the imaged objects have sliding interfaces. Recent extensions to deformable image registration that accommodate for sliding motion of organs are limited to sliding motion along approximately planar surfaces or cannot model sliding that changes the topological configuration in case of multiple organs. We propose a new extension to free-form image registration that is not limited in this way. Our method uses a transformation model that consists of uniform B-spline transformations for each organ region separately, which is based on segmentation of one image. Since this model can create overlapping regions or gaps between regions, we introduce a penalty term that minimizes this undesired effect. The penalty term acts on the surfaces of the organ regions and is optimized simultaneously with the image similarity. To evaluate our method registrations were performed on publicly available inhale-exhale CT scans for which performances of other methods are known. Target registration errors are computed on dense landmark sets that are available with these datasets. On these data our method outperforms the other methods in terms of target registration error and, where applicable, also in terms of overlap and gap volumes. The approximation of the other methods of sliding motion along planar surfaces is reasonably well suited for the motion present in the lung data. The ability of our method to handle sliding along curved boundaries and for changing region topology configurations was demonstrated on synthetic images.

  15. FZUImageReg: A toolbox for medical image registration and dose fusion in cervical cancer radiotherapy

    PubMed Central

    Bai, Penggang; Du, Min; Ni, Xiaolei; Ke, Dongzhong; Tong, Tong

    2017-01-01

    The combination external-beam radiotherapy and high-dose-rate brachytherapy is a standard form of treatment for patients with locally advanced uterine cervical cancer. Personalized radiotherapy in cervical cancer requires efficient and accurate dose planning and assessment across these types of treatment. To achieve radiation dose assessment, accurate mapping of the dose distribution from HDR-BT onto EBRT is extremely important. However, few systems can achieve robust dose fusion and determine the accumulated dose distribution during the entire course of treatment. We have therefore developed a toolbox (FZUImageReg), which is a user-friendly dose fusion system based on hybrid image registration for radiation dose assessment in cervical cancer radiotherapy. The main part of the software consists of a collection of medical image registration algorithms and a modular design with a user-friendly interface, which allows users to quickly configure, test, monitor, and compare different registration methods for a specific application. Owing to the large deformation, the direct application of conventional state-of-the-art image registration methods is not sufficient for the accurate alignment of EBRT and HDR-BT images. To solve this problem, a multi-phase non-rigid registration method using local landmark-based free-form deformation is proposed for locally large deformation between EBRT and HDR-BT images, followed by intensity-based free-form deformation. With the transformation, the software also provides a dose mapping function according to the deformation field. The total dose distribution during the entire course of treatment can then be presented. Experimental results clearly show that the proposed system can achieve accurate registration between EBRT and HDR-BT images and provide radiation dose warping and fusion results for dose assessment in cervical cancer radiotherapy in terms of high accuracy and efficiency. PMID:28388623

  16. 75 FR 43166 - Information Collection; Central Contractor Registration Requirements for Prime Grant Recipients

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ...] Information Collection; Central Contractor Registration Requirements for Prime Grant Recipients AGENCY: Office... information collection requirement regarding Central Contractor Registration Requirements for Prime Grant... for the proper performance of functions of the Central Contractor Registration Requirements for Prime...

  17. 16 CFR 1130.8 - Requirements for Web site registration or alternative e-mail registration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Requirements for Web site registration or... PRODUCTS (Eff. June 28, 2010) § 1130.8 Requirements for Web site registration or alternative e-mail registration. (a) Link to registration page. The manufacturer's Web site, or other Web site established for the...

  18. 16 CFR § 1130.8 - Requirements for Web site registration or alternative e-mail registration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Requirements for Web site registration or... OR TODDLER PRODUCTS § 1130.8 Requirements for Web site registration or alternative e-mail registration. (a) Link to registration page. The manufacturer's Web site, or other Web site established for the...

  19. The Input-Interface of Webcam Applied in 3D Virtual Reality Systems

    ERIC Educational Resources Information Center

    Sun, Huey-Min; Cheng, Wen-Lin

    2009-01-01

    Our research explores a virtual reality application based on Web camera (Webcam) input-interface. The interface can replace with the mouse to control direction intention of a user by the method of frame difference. We divide a frame into nine grids from Webcam and make use of the background registration to compute the moving object. In order to…

  20. Technical note: DIRART--A software suite for deformable image registration and adaptive radiotherapy research.

    PubMed

    Yang, Deshan; Brame, Scott; El Naqa, Issam; Aditya, Apte; Wu, Yu; Goddu, S Murty; Mutic, Sasa; Deasy, Joseph O; Low, Daniel A

    2011-01-01

    Recent years have witnessed tremendous progress in image guide radiotherapy technology and a growing interest in the possibilities for adapting treatment planning and delivery over the course of treatment. One obstacle faced by the research community has been the lack of a comprehensive open-source software toolkit dedicated for adaptive radiotherapy (ART). To address this need, the authors have developed a software suite called the Deformable Image Registration and Adaptive Radiotherapy Toolkit (DIRART). DIRART is an open-source toolkit developed in MATLAB. It is designed in an object-oriented style with focus on user-friendliness, features, and flexibility. It contains four classes of DIR algorithms, including the newer inverse consistency algorithms to provide consistent displacement vector field in both directions. It also contains common ART functions, an integrated graphical user interface, a variety of visualization and image-processing features, dose metric analysis functions, and interface routines. These interface routines make DIRART a powerful complement to the Computational Environment for Radiotherapy Research (CERR) and popular image-processing toolkits such as ITK. DIRART provides a set of image processing/registration algorithms and postprocessing functions to facilitate the development and testing of DIR algorithms. It also offers a good amount of options for DIR results visualization, evaluation, and validation. By exchanging data with treatment planning systems via DICOM-RT files and CERR, and by bringing image registration algorithms closer to radiotherapy applications, DIRART is potentially a convenient and flexible platform that may facilitate ART and DIR research. 0 2011 Ameri-

  1. The Design of SimpleITK.

    PubMed

    Lowekamp, Bradley C; Chen, David T; Ibáñez, Luis; Blezek, Daniel

    2013-01-01

    SimpleITK is a new interface to the Insight Segmentation and Registration Toolkit (ITK) designed to facilitate rapid prototyping, education and scientific activities via high level programming languages. ITK is a templated C++ library of image processing algorithms and frameworks for biomedical and other applications, and it was designed to be generic, flexible and extensible. Initially, ITK provided a direct wrapping interface to languages such as Python and Tcl through the WrapITK system. Unlike WrapITK, which exposed ITK's complex templated interface, SimpleITK was designed to provide an easy to use and simplified interface to ITK's algorithms. It includes procedural methods, hides ITK's demand driven pipeline, and provides a template-less layer. Also SimpleITK provides practical conveniences such as binary distribution packages and overloaded operators. Our user-friendly design goals dictated a departure from the direct interface wrapping approach of WrapITK, toward a new facade class structure that only exposes the required functionality, hiding ITK's extensive template use. Internally SimpleITK utilizes a manual description of each filter with code-generation and advanced C++ meta-programming to provide the higher-level interface, bringing the capabilities of ITK to a wider audience. SimpleITK is licensed as open source software library under the Apache License Version 2.0 and more information about downloading it can be found at http://www.simpleitk.org.

  2. Pesticide Registration Manual: Chapter 10 - Data Compensation Requirements

    EPA Pesticide Factsheets

    This chapter provides information about data compensation requirements, procedures, and obligations when submitting an application for registration, amended registration, reregistration or registration review.

  3. 14 CFR 47.3 - Registration required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGISTRATION General § 47.3 Registration required. (a) An aircraft may be registered under 49 U.S.C. 44103 only... person may operate an aircraft that is eligible for registration under 49 U.S.C. 44101-44104, unless the... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Registration required. 47.3 Section 47.3...

  4. 14 CFR 47.3 - Registration required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGISTRATION General § 47.3 Registration required. (a) An aircraft may be registered under 49 U.S.C. 44103 only... person may operate an aircraft that is eligible for registration under 49 U.S.C. 44101-44104, unless the... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Registration required. 47.3 Section 47.3...

  5. 14 CFR 47.3 - Registration required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGISTRATION General § 47.3 Registration required. (a) An aircraft may be registered under 49 U.S.C. 44103 only... eligible for registration under 49 U.S.C. 44101-44104, unless the aircraft— (1) Has been registered by its... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Registration required. 47.3 Section 47.3...

  6. 14 CFR 47.3 - Registration required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGISTRATION General § 47.3 Registration required. (a) An aircraft may be registered under 49 U.S.C. 44103 only... person may operate an aircraft that is eligible for registration under 49 U.S.C. 44101-44104, unless the... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Registration required. 47.3 Section 47.3...

  7. 14 CFR 47.3 - Registration required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGISTRATION General § 47.3 Registration required. (a) An aircraft may be registered under 49 U.S.C. 44103 only... person may operate an aircraft that is eligible for registration under 49 U.S.C. 44101-44104, unless the... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Registration required. 47.3 Section 47.3...

  8. 78 FR 44559 - Effective Date of Revised Company Registration Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... are registered to make that type of filing. \\1\\ Revisions to Company Registration and Establishing...; and RM12-3-000] Effective Date of Revised Company Registration Requirements AGENCY: Federal Energy... Revised Company Registration Requirements. The Commission issued a Notice in the Federal Register, 78 FR...

  9. VOMS/VOMRS utilization patterns and convergence plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ceccanti, A.; /INFN, CNAF; Ciaschini, V.

    2010-01-01

    The Grid community uses two well-established registration services, which allow users to be authenticated under the auspices of Virtual Organizations (VOs). The Virtual Organization Membership Service (VOMS), developed in the context of the Enabling Grid for E-sciencE (EGEE) project, is an Attribute Authority service that issues attributes expressing membership information of a subject within a VO. VOMS allows to partition users in groups, assign them roles and free-form attributes which are then used to drive authorization decisions. The VOMS administrative application, VOMS-Admin, manages and populates the VOMS database with membership information. The Virtual Organization Management Registration Service (VOMRS), developed atmore » Fermilab, extends the basic registration and management functionalities present in VOMS-Admin. It implements a registration workflow that requires VO usage policy acceptance and membership approval by administrators. VOMRS supports management of multiple grid certificates, and handling users' request for group and role assignments, and membership status. VOMRS is capable of interfacing to local systems with personnel information (e.g. the CERN Human Resource Database) and of pulling relevant member information from them. VOMRS synchronizes the relevant subset of information with VOMS. The recent development of new features in VOMS-Admin raises the possibility of rationalizing the support and converging on a single solution by continuing and extending existing collaborations between EGEE and OSG. Such strategy is supported by WLCG, OSG, US CMS, US Atlas, and other stakeholders worldwide. In this paper, we will analyze features in use by major experiments and the use cases for registration addressed by the mature single solution.« less

  10. VOMS/VOMRS utilization patterns and convergence plan

    NASA Astrophysics Data System (ADS)

    Ceccanti, A.; Ciaschini, V.; Dimou, M.; Garzoglio, G.; Levshina, T.; Traylen, S.; Venturi, V.

    2010-04-01

    The Grid community uses two well-established registration services, which allow users to be authenticated under the auspices of Virtual Organizations (VOs). The Virtual Organization Membership Service (VOMS), developed in the context of the Enabling Grid for E-sciencE (EGEE) project, is an Attribute Authority service that issues attributes expressing membership information of a subject within a VO. VOMS allows to partition users in groups, assign them roles and free-form attributes which are then used to drive authorization decisions. The VOMS administrative application, VOMS-Admin, manages and populates the VOMS database with membership information. The Virtual Organization Management Registration Service (VOMRS), developed at Fermilab, extends the basic registration and management functionalities present in VOMS-Admin. It implements a registration workflow that requires VO usage policy acceptance and membership approval by administrators. VOMRS supports management of multiple grid certificates, and handling users' request for group and role assignments, and membership status. VOMRS is capable of interfacing to local systems with personnel information (e.g. the CERN Human Resource Database) and of pulling relevant member information from them. VOMRS synchronizes the relevant subset of information with VOMS. The recent development of new features in VOMS-Admin raises the possibility of rationalizing the support and converging on a single solution by continuing and extending existing collaborations between EGEE and OSG. Such strategy is supported by WLCG, OSG, US CMS, US Atlas, and other stakeholders worldwide. In this paper, we will analyze features in use by major experiments and the use cases for registration addressed by the mature single solution.

  11. 31 CFR 359.53 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series I...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (TINs) required for registration of book-entry Series I savings bonds? 359.53 Section 359.53 Money and... Savings Bonds § 359.53 Are taxpayer identification numbers (TINs) required for registration of book-entry Series I savings bonds? The TIN of each person named in the registration is required to purchase a book...

  12. 31 CFR 351.68 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (TINs) required for registration of book-entry Series EE savings bonds? 351.68 Section 351.68 Money and... Savings Bonds § 351.68 Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE savings bonds? The TIN of each person named in the registration is required to purchase a book...

  13. 31 CFR 359.53 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series I...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (TINs) required for registration of book-entry Series I savings bonds? 359.53 Section 359.53 Money and... Savings Bonds § 359.53 Are taxpayer identification numbers (TINs) required for registration of book-entry Series I savings bonds? The TIN of each person named in the registration is required to purchase a book...

  14. 31 CFR 351.68 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (TINs) required for registration of book-entry Series EE savings bonds? 351.68 Section 351.68 Money and... EE Savings Bonds § 351.68 Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE savings bonds? The TIN of each person named in the registration is required to...

  15. 31 CFR 359.53 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series I...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (TINs) required for registration of book-entry Series I savings bonds? 359.53 Section 359.53 Money and... Savings Bonds § 359.53 Are taxpayer identification numbers (TINs) required for registration of book-entry Series I savings bonds? The TIN of each person named in the registration is required to purchase a book...

  16. 31 CFR 351.68 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (TINs) required for registration of book-entry Series EE savings bonds? 351.68 Section 351.68 Money and... Savings Bonds § 351.68 Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE savings bonds? The TIN of each person named in the registration is required to purchase a book...

  17. 31 CFR 359.53 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series I...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (TINs) required for registration of book-entry Series I savings bonds? 359.53 Section 359.53 Money and... Savings Bonds § 359.53 Are taxpayer identification numbers (TINs) required for registration of book-entry Series I savings bonds? The TIN of each person named in the registration is required to purchase a book...

  18. 31 CFR 351.68 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (TINs) required for registration of book-entry Series EE savings bonds? 351.68 Section 351.68 Money and... Savings Bonds § 351.68 Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE savings bonds? The TIN of each person named in the registration is required to purchase a book...

  19. 31 CFR 359.53 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series I...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (TINs) required for registration of book-entry Series I savings bonds? 359.53 Section 359.53 Money and... Savings Bonds § 359.53 Are taxpayer identification numbers (TINs) required for registration of book-entry Series I savings bonds? The TIN of each person named in the registration is required to purchase a book...

  20. 31 CFR 351.68 - Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (TINs) required for registration of book-entry Series EE savings bonds? 351.68 Section 351.68 Money and... Savings Bonds § 351.68 Are taxpayer identification numbers (TINs) required for registration of book-entry Series EE savings bonds? The TIN of each person named in the registration is required to purchase a book...

  1. Technical Note: DIRART – A software suite for deformable image registration and adaptive radiotherapy research

    PubMed Central

    Yang, Deshan; Brame, Scott; El Naqa, Issam; Aditya, Apte; Wu, Yu; Murty Goddu, S.; Mutic, Sasa; Deasy, Joseph O.; Low, Daniel A.

    2011-01-01

    Purpose: Recent years have witnessed tremendous progress in image guide radiotherapy technology and a growing interest in the possibilities for adapting treatment planning and delivery over the course of treatment. One obstacle faced by the research community has been the lack of a comprehensive open-source software toolkit dedicated for adaptive radiotherapy (ART). To address this need, the authors have developed a software suite called the Deformable Image Registration and Adaptive Radiotherapy Toolkit (DIRART). Methods:DIRART is an open-source toolkit developed in MATLAB. It is designed in an object-oriented style with focus on user-friendliness, features, and flexibility. It contains four classes of DIR algorithms, including the newer inverse consistency algorithms to provide consistent displacement vector field in both directions. It also contains common ART functions, an integrated graphical user interface, a variety of visualization and image-processing features, dose metric analysis functions, and interface routines. These interface routines make DIRART a powerful complement to the Computational Environment for Radiotherapy Research (CERR) and popular image-processing toolkits such as ITK. Results: DIRART provides a set of image processing∕registration algorithms and postprocessing functions to facilitate the development and testing of DIR algorithms. It also offers a good amount of options for DIR results visualization, evaluation, and validation. Conclusions: By exchanging data with treatment planning systems via DICOM-RT files and CERR, and by bringing image registration algorithms closer to radiotherapy applications, DIRART is potentially a convenient and flexible platform that may facilitate ART and DIR research. PMID:21361176

  2. Registration and Marking Requirements for UAS. Unmanned Aircraft System (UAS) Registration

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The registration of an aircraft is a prerequisite for issuance of a U.S. certificate of airworthiness by the FAA. The procedures and requirements for aircraft registration, and the subsequent issuance of registration numbers, are contained in FAR Part 47. However, the process/method(s) for applying the requirements of Parts 45 & 47 to Unmanned Aircraft Systems (UAS) has not been defined. This task resolved the application of 14 CFR Parts 45 and 47 to UAS. Key Findings: UAS are aircraft systems and as such the recommended approach to registration is to follow the same process for registration as manned aircraft. This will require manufacturers to comply with the requirements for 14 CFR 47, Aircraft Registration and 14 CFR 45, Identification and Registration Marking. In addition, only the UA should be identified with the N number registration markings. There should also be a documentation link showing the applicability of the control station and communication link to the UA. The documentation link can be in the form of a Type Certificate Data Sheet (TCDS) entry or a UAS logbook entry. The recommended process for the registration of UAS is similar to the manned aircraft process and is outlined in a 6-step process in the paper.

  3. The Design of SimpleITK

    PubMed Central

    Lowekamp, Bradley C.; Chen, David T.; Ibáñez, Luis; Blezek, Daniel

    2013-01-01

    SimpleITK is a new interface to the Insight Segmentation and Registration Toolkit (ITK) designed to facilitate rapid prototyping, education and scientific activities via high level programming languages. ITK is a templated C++ library of image processing algorithms and frameworks for biomedical and other applications, and it was designed to be generic, flexible and extensible. Initially, ITK provided a direct wrapping interface to languages such as Python and Tcl through the WrapITK system. Unlike WrapITK, which exposed ITK's complex templated interface, SimpleITK was designed to provide an easy to use and simplified interface to ITK's algorithms. It includes procedural methods, hides ITK's demand driven pipeline, and provides a template-less layer. Also SimpleITK provides practical conveniences such as binary distribution packages and overloaded operators. Our user-friendly design goals dictated a departure from the direct interface wrapping approach of WrapITK, toward a new facade class structure that only exposes the required functionality, hiding ITK's extensive template use. Internally SimpleITK utilizes a manual description of each filter with code-generation and advanced C++ meta-programming to provide the higher-level interface, bringing the capabilities of ITK to a wider audience. SimpleITK is licensed as open source software library under the Apache License Version 2.0 and more information about downloading it can be found at http://www.simpleitk.org. PMID:24416015

  4. PROFESSIONAL REGISTRATION OF GOVERNMENT ENGINEERS.

    USGS Publications Warehouse

    Buchanan, Thomas J.

    1985-01-01

    The American Society of Civil Engineers views professional registration as an appropriate requirement for engineers, including those in government. The National Society of Professional Engineers makes registration a requirement for the grade of member and full privileges in the society. Some Federal agencies require engineering registration for certain positions in their agencies. Engineers in government service should consider the value of engineering registration to themselves and to their agencies and take pride in their professions and in their own capabilities by becoming registered engineers. They should also take steps to encourage their agencies to give more attention to engineering registration.

  5. 14 CFR 47.15 - Registration number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGISTRATION General § 47.15 Registration number. (a) Number required. An applicant for aircraft registration must place a U.S. registration number (registration mark) on the Aircraft Registration Application, AC... Dealer's Aircraft Registration Certificate, AC Form 8050-6, who applies for a temporary registration...

  6. 14 CFR 47.15 - Registration number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGISTRATION General § 47.15 Registration number. (a) Number required. An applicant for aircraft registration must place a U.S. registration number (registration mark) on the Aircraft Registration Application, AC... Dealer's Aircraft Registration Certificate, AC Form 8050-6, who applies for a temporary registration...

  7. 14 CFR 47.15 - Registration number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGISTRATION General § 47.15 Registration number. (a) Number required. An applicant for aircraft registration must place a U.S. registration number (registration mark) on the Aircraft Registration Application, AC... Dealer's Aircraft Registration Certificate, AC Form 8050-6, who applies for a temporary registration...

  8. 14 CFR 47.15 - Registration number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGISTRATION General § 47.15 Registration number. (a) Number required. An applicant for aircraft registration must place a U.S. registration number (registration mark) on the Aircraft Registration Application, AC... Dealer's Aircraft Registration Certificate, AC Form 8050-6, who applies for a temporary registration...

  9. Optical registration of spaceborne low light remote sensing camera

    NASA Astrophysics Data System (ADS)

    Li, Chong-yang; Hao, Yan-hui; Xu, Peng-mei; Wang, Dong-jie; Ma, Li-na; Zhao, Ying-long

    2018-02-01

    For the high precision requirement of spaceborne low light remote sensing camera optical registration, optical registration of dual channel for CCD and EMCCD is achieved by the high magnification optical registration system. System integration optical registration and accuracy of optical registration scheme for spaceborne low light remote sensing camera with short focal depth and wide field of view is proposed in this paper. It also includes analysis of parallel misalignment of CCD and accuracy of optical registration. Actual registration results show that imaging clearly, MTF and accuracy of optical registration meet requirements, it provide important guarantee to get high quality image data in orbit.

  10. 78 FR 79455 - Information Collection; System for Award Management Registration Requirements for Prime Grant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ...Under the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35), the Regulatory Secretariat Division will be submitting to the Office of Management and Budget (OMB) a request to review and approve a renewal of the currently approved information collection requirement regarding the pre-award registration requirements for Prime Grant Recipients. The title of the approved information collection is Central Contractor Registration Requirements for Prime Grant Recipients (OMB Control Number 3090-0290). The updated information collection title, based on the migration of the Central Contractor Registration system to the System for Award Management in late July 2012, is System for Award Management Registration Requirements for Prime Grant Recipients.

  11. 21 CFR 118.11 - Registration requirements for shell egg producers covered by the requirements of this part.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Registration requirements for shell egg producers..., STORAGE, AND TRANSPORTATION OF SHELL EGGS § 118.11 Registration requirements for shell egg producers covered by the requirements of this part. (a) Shell egg producers covered under § 118.1(a) are required to...

  12. 78 FR 79454 - Information Collection; FSRS Registration Requirements for Prime Grant Awardees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ...Under the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35), the Regulatory Secretariat Division will be submitting to the Office of Management and Budget (OMB) a request to review and approve a renewal of the currently approved information collection requirement regarding FSRS Registration Requirements for Prime Grant Awardees. The title of the approved information collection is FSRS Registration and Prime Awardee Entity- Related Information Reporting Requirements. To clarify the purpose of the information collection, the updated title is FSRS Registration Requirements for Prime Grant Awardees.

  13. Clinical trial registration in oral health journals.

    PubMed

    Smaïl-Faugeron, V; Fron-Chabouis, H; Durieux, P

    2015-03-01

    Prospective registration of randomized controlled trials (RCTs) represents the best solution to reporting bias. The extent to which oral health journals have endorsed and complied with RCT registration is unknown. We identified journals publishing RCTs in dentistry, oral surgery, and medicine in the Journal Citation Reports. We classified journals into 3 groups: journals requiring or recommending trial registration, journals referring indirectly to registration, and journals providing no reference to registration. For the 5 journals with the highest 2012 impact factors in each group, we assessed whether RCTs with results published in 2013 had been registered. Of 78 journals examined, 32 (41%) required or recommended trial registration, 19 (24%) referred indirectly to registration, and 27 (35%) provided no reference to registration. We identified 317 RCTs with results published in the 15 selected journals in 2013. Overall, 73 (23%) were registered in a trial registry. Among those, 91% were registered retrospectively and 32% did not report trial registration in the published article. The proportion of trials registered was not significantly associated with editorial policies: 29% with results in journals that required or recommended registration, 15% in those that referred indirectly to registration, and 21% in those providing no reference to registration (P = 0.05). Less than one-quarter of RCTs with results published in a sample of oral health journals were registered with a public registry. Improvements are needed with respect to how journals inform and require their authors to register their trials. © International & American Associations for Dental Research.

  14. 21 CFR 118.11 - Registration requirements for shell egg producers covered by the requirements of this part.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Registration requirements for shell egg producers..., STORAGE, AND TRANSPORTATION OF SHELL EGGS § 118.11 Registration requirements for shell egg producers covered by the requirements of this part. (a) Shell egg producers covered under § 118.1(a) of this part...

  15. GIFTed Demons: deformable image registration with local structure-preserving regularization using supervoxels for liver applications

    PubMed Central

    Gleeson, Fergus V.; Brady, Michael; Schnabel, Julia A.

    2018-01-01

    Abstract. Deformable image registration, a key component of motion correction in medical imaging, needs to be efficient and provides plausible spatial transformations that reliably approximate biological aspects of complex human organ motion. Standard approaches, such as Demons registration, mostly use Gaussian regularization for organ motion, which, though computationally efficient, rule out their application to intrinsically more complex organ motions, such as sliding interfaces. We propose regularization of motion based on supervoxels, which provides an integrated discontinuity preserving prior for motions, such as sliding. More precisely, we replace Gaussian smoothing by fast, structure-preserving, guided filtering to provide efficient, locally adaptive regularization of the estimated displacement field. We illustrate the approach by applying it to estimate sliding motions at lung and liver interfaces on challenging four-dimensional computed tomography (CT) and dynamic contrast-enhanced magnetic resonance imaging datasets. The results show that guided filter-based regularization improves the accuracy of lung and liver motion correction as compared to Gaussian smoothing. Furthermore, our framework achieves state-of-the-art results on a publicly available CT liver dataset. PMID:29662918

  16. GIFTed Demons: deformable image registration with local structure-preserving regularization using supervoxels for liver applications.

    PubMed

    Papież, Bartłomiej W; Franklin, James M; Heinrich, Mattias P; Gleeson, Fergus V; Brady, Michael; Schnabel, Julia A

    2018-04-01

    Deformable image registration, a key component of motion correction in medical imaging, needs to be efficient and provides plausible spatial transformations that reliably approximate biological aspects of complex human organ motion. Standard approaches, such as Demons registration, mostly use Gaussian regularization for organ motion, which, though computationally efficient, rule out their application to intrinsically more complex organ motions, such as sliding interfaces. We propose regularization of motion based on supervoxels, which provides an integrated discontinuity preserving prior for motions, such as sliding. More precisely, we replace Gaussian smoothing by fast, structure-preserving, guided filtering to provide efficient, locally adaptive regularization of the estimated displacement field. We illustrate the approach by applying it to estimate sliding motions at lung and liver interfaces on challenging four-dimensional computed tomography (CT) and dynamic contrast-enhanced magnetic resonance imaging datasets. The results show that guided filter-based regularization improves the accuracy of lung and liver motion correction as compared to Gaussian smoothing. Furthermore, our framework achieves state-of-the-art results on a publicly available CT liver dataset.

  17. 76 FR 50481 - Announcement of Requirements and Registration for “Lifeline Facebook App Challenge”; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for ``Lifeline Facebook App Challenge''; Correction AGENCY: Office of the Assistant Secretary for Preparedness... Requirements and Registration for ``Lifeline Facebook App Challenge''. DATES: This correction is effective...

  18. 40 CFR 161.100 - How to determine registration data requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false How to determine registration data requirements. 161.100 Section 161.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES How To Use Data Tables...

  19. 75 FR 18505 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-D-0165] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... veterinary use by the International Cooperation on Harmonisation of Technical Requirements for Registration...

  20. The Role of Health Kiosks in 2009: Literature and Informant Review

    PubMed Central

    Jones, Ray

    2009-01-01

    Kiosks can provide patients with access to health systems in public locations, but with increasing home Internet access their usefulness is questioned. A literature and informant review identified kiosks used for taking medical histories, health promotion, self assessment, consumer feedback, patient registration, patient access to records, and remote consultations. Sited correctly with good interfaces, kiosks can be used by all demographics but many ‘projects’ have failed to become routine practice. A role remains for: (a) integrated kiosks as part of patient ‘flow’, (b) opportunistic kiosks to catch people’s attention. Both require clear ‘ownership’ to succeed. PMID:19578463

  1. Review of registration requirements for new part-time doctors in New Zealand, Australia, the United Kingdom, Ireland and Canada.

    PubMed

    Leitch, Sharon; Dovey, Susan M

    2010-12-01

    By the time medical students graduate many wish to work part-time while accommodating other lifestyle interests. To review flexibility of medical registration requirements for provisional registrants in New Zealand, Australia, the United Kingdom, Ireland and Canada. Internet-based review of registration bodies of each country, and each state or province in Australia and Canada, supplemented by emails and phone calls seeking clarification of missing or obscure information. Data from 20 regions were examined. Many similarities were found between study countries in their approaches to the registration of new doctors, although there are some regional differences. Most regions (65%) have a provisional registration period of one year. Extending this period was possible in 91% of regions. Part-time options were possible in 75% of regions. All regions required trainees to work in approved practice settings. Only the UK provided comprehensive documentation of their requirements in an accessible format and clearly explaining the options for part-time work. Australia appeared to be more flexible than other countries with respect to part- and full-time work requirements. All countries need to examine their registration requirements to introduce more flexibility wherever possible, as a strategy for addressing workforce shortages.

  2. 14 CFR 47.15 - Identification number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGISTRATION General § 47.15 Identification number. (a) Number required. An applicant for Aircraft Registration must place a U.S. identification number (registration mark) on his Aircraft Registration Application... holder of a Dealer's Aircraft Registration Certificate who applies for a temporary registration number...

  3. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... registrations in the Central Contractor Registration (http://www.ccr.gov) at all times during which they have... System (DUNS) Number (http://www.dnb.com) is one of the requirements for registration in the Central... Recovery Act using the reporting instructions and data elements that will be provided online at http://www...

  4. Petition for Rulemaking to Evaluate Synergestic Effects of Pesticides during Registration and Registration Review

    EPA Pesticide Factsheets

    This petition from the Center for Biological Diversity asks that the Agency require all applicants and registrants to provide data on the potential synergistic effects of pesticides during the registration and registration review processes.

  5. Public attitudes toward sexual offenders and sex offender registration.

    PubMed

    Kernsmith, Poco D; Craun, Sarah W; Foster, Jonathan

    2009-01-01

    This study explores the relationship between fear of various types of sexual offenders and a belief that those sexual offenders should be subject to sex offender registration. We hypothesized that those who offend against children would elicit the most fear; consequently, the most feared offenders would be rated as most requiring registration. As part of a telephone survey, 733 participants answered questions about fear of sex offenders and agreement with requirements about registration for offenders convicted of incest, statutory rape, marital rape, pedophilia, date rape, and an offense committed more than 10 years prior. Results indicated that all types of sexual offenders elicited some fear from respondents, and fear was related to support of registration requirements.

  6. Developing an integrated electronic nursing record based on standards.

    PubMed

    van Grunsven, Arno; Bindels, Rianne; Coenen, Chel; de Bel, Ernst

    2006-01-01

    The Radboud University Nijmegen Medical Centre in the Netherlands develops a multidisciplinar (Electronic Health Record) based on the latest HL7 v3 (Health Level 7 version 3) D-MIM : Care provision. As part of this process we are trying to establish which nursing diagnoses and activities are minimally required. These NMDS (Nursing Minimal Data Set) are mapped or translated to ICF (for diagnoses) and CEN1828 Structures for (for activities). The mappings will be the foundation for the development of user interfaces for the registration of nursing activities. A homegrown custom-made web based configuration tool is used to exploit the possibilities of HL7 v3. This enables a sparkling launch of user interfaces that can contain the diversity of health care work processes. The first screens will be developed to support history taking for the nursing chart of the Neurology ward. The screens will contain both Dutch NMDS items and ward specific information. This will be configured dynamically per (group of) ward(s).

  7. 76 FR 35266 - Reports, Forms and Record Keeping Requirements; Agency Information Collection Activity Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-16

    ... ``Consolidated Child Restraint System Registration, Labeling and Defect Notification.'' (OMB Control Number: 2127... Traffic Safety Administration. Title: Consolidated Child Restraint System Registration, Labeling and... collection. Abstract: Child restraint manufacturers are required to provide an owner's registration card for...

  8. Irish nursing students' changing levels of assertiveness during their pre-registration programme.

    PubMed

    Begley, Cecily M; Glacken, Michèle

    2004-10-01

    Stress and bullying have been found to be common problems in a number of studies of Irish nursing and midwifery. Victims of bullying need high levels of assertiveness to enable them to withstand the stress of victimization. It was deemed important to measure nursing students' level of assertiveness prior to, and near completion of, their pre-registration education programme. Aim. To ascertain nursing students' perceived levels of assertiveness prior to, and nearing the completion of, their three-year pre-registration programme. Ethical approval was given. The students commencing general nurse education programmes in two schools in Southern Ireland agreed to take part (n=72). A questionnaire adapted from a number of assertiveness scales, and tested for validity and reliability in this population, was used to collect data. In general, students' reported assertiveness levels rose as they approached completion of their three-year education programme. The resource constrained health service of the 21st century requires nurses who are assertive to meet the needs of its users. Nursing students' assertiveness skills could be augmented through concentrated efforts from nurse educationalists and clinicians to reduce the communication theory practice gap in nurse education today. To address the multi-dimensional nature of assertiveness, strategies to increase assertiveness should operate at the individual, interface and organisational level. The students in this study reported an increase in levels of assertiveness as they approached completion of their three-year education programme. To function as effective, safe practitioners registered nurses need to be assertive, therefore education in assertiveness should be an integral part of their preparation. The precise composition and mode of delivery of this education requires exploration and evaluation.

  9. A prospective comparison between auto-registration and manual registration of real-time ultrasound with MR images for percutaneous ablation or biopsy of hepatic lesions.

    PubMed

    Cha, Dong Ik; Lee, Min Woo; Song, Kyoung Doo; Oh, Young-Taek; Jeong, Ja-Yeon; Chang, Jung-Woo; Ryu, Jiwon; Lee, Kyong Joon; Kim, Jaeil; Bang, Won-Chul; Shin, Dong Kuk; Choi, Sung Jin; Koh, Dalkwon; Seo, Bong Koo; Kim, Kyunga

    2017-06-01

    To compare the accuracy and required time for image fusion of real-time ultrasound (US) with pre-procedural magnetic resonance (MR) images between positioning auto-registration and manual registration for percutaneous radiofrequency ablation or biopsy of hepatic lesions. This prospective study was approved by the institutional review board, and all patients gave written informed consent. Twenty-two patients (male/female, n = 18/n = 4; age, 61.0 ± 7.7 years) who were referred for planning US to assess the feasibility of radiofrequency ablation (n = 21) or biopsy (n = 1) for focal hepatic lesions were included. One experienced radiologist performed the two types of image fusion methods in each patient. The performance of auto-registration and manual registration was evaluated. The accuracy of the two methods, based on measuring registration error, and the time required for image fusion for both methods were recorded using in-house software and respectively compared using the Wilcoxon signed rank test. Image fusion was successful in all patients. The registration error was not significantly different between the two methods (auto-registration: median, 3.75 mm; range, 1.0-15.8 mm vs. manual registration: median, 2.95 mm; range, 1.2-12.5 mm, p = 0.242). The time required for image fusion was significantly shorter with auto-registration than with manual registration (median, 28.5 s; range, 18-47 s, vs. median, 36.5 s; range, 14-105 s, p = 0.026). Positioning auto-registration showed promising results compared with manual registration, with similar accuracy and even shorter registration time.

  10. 40 CFR 152.44 - Application for amended registration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... registration. The applicant must submit the information required by § 152.50, as applicable to the change...) Require that the applicant certify to the Agency that he has complied with an Agency directive rather than... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Application for amended registration...

  11. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a) Form...

  12. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a) Form...

  13. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Domestic Blood Product Establishments § 607.25 Information required for establishment registration and blood product listing. (a) Form...

  14. 40 CFR 79.22 - Determination of noncompliance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.22 Determination... fuel additive has failed to submit all of the information required by § 79.21, or determines within the... which is required prior to registration of the fuel additive by any provision of subpart F of this part...

  15. 40 CFR 79.22 - Determination of noncompliance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.22 Determination... fuel additive has failed to submit all of the information required by § 79.21, or determines within the... which is required prior to registration of the fuel additive by any provision of subpart F of this part...

  16. 40 CFR 79.22 - Determination of noncompliance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.22 Determination... fuel additive has failed to submit all of the information required by § 79.21, or determines within the... which is required prior to registration of the fuel additive by any provision of subpart F of this part...

  17. 40 CFR 79.22 - Determination of noncompliance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.22 Determination... fuel additive has failed to submit all of the information required by § 79.21, or determines within the... which is required prior to registration of the fuel additive by any provision of subpart F of this part...

  18. 40 CFR 79.22 - Determination of noncompliance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) REGISTRATION OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.22 Determination... fuel additive has failed to submit all of the information required by § 79.21, or determines within the... which is required prior to registration of the fuel additive by any provision of subpart F of this part...

  19. WeBIAS: a web server for publishing bioinformatics applications.

    PubMed

    Daniluk, Paweł; Wilczyński, Bartek; Lesyng, Bogdan

    2015-11-02

    One of the requirements for a successful scientific tool is its availability. Developing a functional web service, however, is usually considered a mundane and ungratifying task, and quite often neglected. When publishing bioinformatic applications, such attitude puts additional burden on the reviewers who have to cope with poorly designed interfaces in order to assess quality of presented methods, as well as impairs actual usefulness to the scientific community at large. In this note we present WeBIAS-a simple, self-contained solution to make command-line programs accessible through web forms. It comprises a web portal capable of serving several applications and backend schedulers which carry out computations. The server handles user registration and authentication, stores queries and results, and provides a convenient administrator interface. WeBIAS is implemented in Python and available under GNU Affero General Public License. It has been developed and tested on GNU/Linux compatible platforms covering a vast majority of operational WWW servers. Since it is written in pure Python, it should be easy to deploy also on all other platforms supporting Python (e.g. Windows, Mac OS X). Documentation and source code, as well as a demonstration site are available at http://bioinfo.imdik.pan.pl/webias . WeBIAS has been designed specifically with ease of installation and deployment of services in mind. Setting up a simple application requires minimal effort, yet it is possible to create visually appealing, feature-rich interfaces for query submission and presentation of results.

  20. A mobile field-work data collection system for the wireless era of health surveillance.

    PubMed

    Forsell, Marianne; Sjögren, Petteri; Renard, Matthew; Johansson, Olle

    2011-03-01

    In many countries or regions the capacity of health care resources is below the needs of the population and new approaches for health surveillance are needed. Innovative projects, utilizing wireless communication technology, contribute to reliable methods for field-work data collection and reporting to databases. The objective was to describe a new version of a wireless IT-support system for field-work data collection and administration. The system requirements were drawn from the design objective and translated to system functions. The system architecture was based on fieldwork experiences and administrative requirements. The Smartphone devices were HTC Touch Diamond2s, while the system was based on a platform with Microsoft .NET components, and a SQL Server 2005 with Microsoft Windows Server 2003 operating system. The user interfaces were based on .NET programming, and Microsoft Windows Mobile operating system. A synchronization module enabled download of field data to the database, via a General Packet Radio Services (GPRS) to a Local Area Network (LAN) interface. The field-workers considered the here-described applications user-friendly and almost self-instructing. The office administrators considered that the back-office interface facilitated retrieval of health reports and invoice distribution. The current IT-support system facilitates short lead times from fieldwork data registration to analysis, and is suitable for various applications. The advantages of wireless technology, and paper-free data administration need to be increasingly emphasized in development programs, in order to facilitate reliable and transparent use of limited resources.

  1. TH-EF-BRA-03: Assessment of Data-Driven Respiratory Motion-Compensation Methods for 4D-CBCT Image Registration and Reconstruction Using Clinical Datasets

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Riblett, MJ; Weiss, E; Hugo, GD

    Purpose: To evaluate the performance of a 4D-CBCT registration and reconstruction method that corrects for respiratory motion and enhances image quality under clinically relevant conditions. Methods: Building on previous work, which tested feasibility of a motion-compensation workflow using image datasets superior to clinical acquisitions, this study assesses workflow performance under clinical conditions in terms of image quality improvement. Evaluated workflows utilized a combination of groupwise deformable image registration (DIR) and image reconstruction. Four-dimensional cone beam CT (4D-CBCT) FDK reconstructions were registered to either mean or respiratory phase reference frame images to model respiratory motion. The resulting 4D transformation was usedmore » to deform projection data during the FDK backprojection operation to create a motion-compensated reconstruction. To simulate clinically realistic conditions, superior quality projection datasets were sampled using a phase-binned striding method. Tissue interface sharpness (TIS) was defined as the slope of a sigmoid curve fit to the lung-diaphragm boundary or to the carina tissue-airway boundary when no diaphragm was discernable. Image quality improvement was assessed in 19 clinical cases by evaluating mitigation of view-aliasing artifacts, tissue interface sharpness recovery, and noise reduction. Results: For clinical datasets, evaluated average TIS recovery relative to base 4D-CBCT reconstructions was observed to be 87% using fixed-frame registration alone; 87% using fixed-frame with motion-compensated reconstruction; 92% using mean-frame registration alone; and 90% using mean-frame with motion-compensated reconstruction. Soft tissue noise was reduced on average by 43% and 44% for the fixed-frame registration and registration with motion-compensation methods, respectively, and by 40% and 42% for the corresponding mean-frame methods. Considerable reductions in view aliasing artifacts were observed for each method. Conclusion: Data-driven groupwise registration and motion-compensated reconstruction have the potential to improve the quality of 4D-CBCT images acquired under clinical conditions. For clinical image datasets, the addition of motion compensation after groupwise registration visibly reduced artifact impact. This work was supported by the National Cancer Institute of the National Institutes of Health under Award Number R01CA166119. Hugo and Weiss hold a research agreement with Philips Healthcare and license agreement with Varian Medical Systems. Weiss receives royalties from UpToDate. Christensen receives funds from Roger Koch to support research.« less

  2. 17 CFR 240.13p-1 - Requirement of report regarding disclosure of registrant's supply chain information regarding...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Requirement of report regarding disclosure of registrant's supply chain information regarding conflict minerals. 240.13p-1 Section...'s supply chain information regarding conflict minerals. Every registrant that files reports with the...

  3. 17 CFR 240.13p-1 - Requirement of report regarding disclosure of registrant's supply chain information regarding...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Requirement of report regarding disclosure of registrant's supply chain information regarding conflict minerals. 240.13p-1 Section...'s supply chain information regarding conflict minerals. Every registrant that files reports with the...

  4. 17 CFR 230.428 - Documents constituting a section 10(a) prospectus for Form S-8 registration statement...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... employee benefit plan information required by Item 1 of the Form; (ii) The statement of availability of registrant information, employee benefit plan annual reports and other information required by Item 2; and (iii) The documents containing registrant information and employee benefit plan annual reports that are...

  5. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Foreign...

  6. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Foreign...

  7. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Foreign...

  8. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Foreign...

  9. 21 CFR 607.40 - Establishment registration and blood product listing requirements for foreign blood product...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Establishment registration and blood product listing requirements for foreign blood product establishments. 607.40 Section 607.40 Food and Drugs FOOD... REGISTRATION AND PRODUCT LISTING FOR MANUFACTURERS OF HUMAN BLOOD AND BLOOD PRODUCTS Procedures for Foreign...

  10. 17 CFR 210.2-04 - Examination of financial statements of persons other than the registrant.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SECURITIES AND EXCHANGE COMMISSION FORM AND CONTENT OF AND REQUIREMENTS FOR FINANCIAL STATEMENTS, SECURITIES... Qualifications and Reports of Accountants § 210.2-04 Examination of financial statements of persons other than the registrant. If a registrant is required to file financial statements of any other person, such...

  11. 77 FR 17105 - Identification of Interstate Motor Vehicles: City of Chicago, IL Registration Emblem Requirement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ...-0086] Identification of Interstate Motor Vehicles: City of Chicago, IL Registration Emblem Requirement...) requesting a determination that the Commercial Motor Vehicle (CMV) identification requirement imposed by the... categories of excepted requirements. The first includes identification requirements related to motor vehicle...

  12. Pesticide Registration Manual: Chapter 12 - Applying for an Experimental Use Permit

    EPA Pesticide Factsheets

    This chapter of the pesticide registration manual describes the all requirements for Experimental Use Permits (EUP), and includes how to apply for an EUP, labeling requirements, application format, and data reporting requirements.

  13. 76 FR 74841 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ..., page 59185. Aircraft owners are required to complete the Aircraft Registration Renewal to verify the registration information and renew registration triennially. The information collected on an Aircraft Re- Registration Application, AC Form 8050-1A will be used by the FAA to verify and update aircraft registration...

  14. Graphical user interface for intraoperative neuroimage updating

    NASA Astrophysics Data System (ADS)

    Rick, Kyle R.; Hartov, Alex; Roberts, David W.; Lunn, Karen E.; Sun, Hai; Paulsen, Keith D.

    2003-05-01

    Image-guided neurosurgery typically relies on preoperative imaging information that is subject to errors resulting from brain shift and deformation in the OR. A graphical user interface (GUI) has been developed to facilitate the flow of data from OR to image volume in order to provide the neurosurgeon with updated views concurrent with surgery. Upon acquisition of registration data for patient position in the OR (using fiducial markers), the Matlab GUI displays ultrasound image overlays on patient specific, preoperative MR images. Registration matrices are also applied to patient-specific anatomical models used for image updating. After displaying the re-oriented brain model in OR coordinates and digitizing the edge of the craniotomy, gravitational sagging of the brain is simulated using the finite element method. Based on this model, interpolation to the resolution of the preoperative images is performed and re-displayed to the surgeon during the procedure. These steps were completed within reasonable time limits and the interface was relatively easy to use after a brief training period. The techniques described have been developed and used retrospectively prior to this study. Based on the work described here, these steps can now be accomplished in the operating room and provide near real-time feedback to the surgeon.

  15. The GEOSS Component and Service Registry

    NASA Astrophysics Data System (ADS)

    Di, L.; Bai, Y.; Shen, D.; Shao, Y.; Shrestha, R.; Wang, H.; Nebert, D. D.

    2011-12-01

    Petabytes of Earth science data have been accumulated through space- and air-borne Earth observation programs during the last several decades. The data are valuable both scientifically and socioeconomically. The value of these data could be further increased significantly if the data from these programs can be easily discovered, accessed, integrated, and analyzed. The Global Earth Observation System of Systems (GEOSS) is addressing this need. Coordinated by the Group on Earth Observations (or GEO), a voluntary partnership of 86 governments, the European Commission, and 61 intergovernmental, international, and regional organizations has been working on implementing GEOSS for a number of years. After four years of international collaboration, the GEOSS Common Infrastructure (GCI) has been established. GCI consists of the Standards and Interoperability Registry (SIR), the Component and Service Registry (CSR), the GEO clearinghouse, and the GEO Portal. The SIR maintains the list of the public standards recognized by the GEO. CSR provides a centralized registry for available Earth Observation resources. The GEO clearinghouse works as a single search facility for GEOSS-wide resources and the GEO Portal provides an integrated Web-based interfaces for users. Since January 2007, researchers at CSISS, GMU have collaborated with officials from the Federal Geographic Data Committee (FGDC) on designing, implementing, maintaining, and upgrading CSR. Currently CSR provides the following capabilities for data providers: user registration, resource registration, and service interface registration. The CSR clients can discover the resources registered in CSR through OGC Catalog for Web (CSW), UUDI, and other standard interfaces. During the resource registration process, providers may define detailed descriptive information for their resources, in particular, the targeted societal benefit area and sub-areas of focus, and the targeted critical Earth Observations. The service interfaces to these resources can also be registered with CSR, where standards references information may be supplied. Providers may also self nominate their resources to be part of the GEOSS-DataCORE. The GEOSS-DataCORE was initialized early this year for establishing a distributed pool of documented, well-calibrated, and persistently available key Earth observation datasets, contributed by the GEO community on the basis of full and open exchange (at no more than the cost of reproduction and distribution) and unrestricted access. In this presentation, the CSR system architecture, use cases, and implementation details will be presented and the registration processes illustrated. In addition, how these registered resources could be further discovered and accessed by GEOSS human users and machine clients will also be discussed. Such information is valuable for agencies to promote their data products through GEOSS. It could also help scientists to advertise their research products and initialize new integrative and cooperative efforts within the GEOSS community.

  16. 77 FR 43078 - Federal Acquisition Regulation; Information Collection; Central Contractor Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ...; Information Collection; Central Contractor Registration AGENCY: Department of Defense (DOD), General Services... requirement concerning the Central Contractor Registration database. Public comments are particularly invited... Information Collection 9000- 0159, Central Contractor Registration, by any of the following methods...

  17. 78 FR 12316 - Federal Acquisition Regulation; Information Collection; Central Contractor Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ...; Information Collection; Central Contractor Registration AGENCIES: Department of Defense (DOD), General... collection requirement concerning the Central Contractor Registration database. A notice was published in the... Information Collection 9000- 0159, Central Contractor Registration, by any of the following methods...

  18. 21 CFR 1311.45 - Requirements for registrants that allow powers of attorney to obtain CSOS digital certificates...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... attorney to obtain CSOS digital certificates under their DEA registration. 1311.45 Section 1311.45 Food and... PRESCRIPTIONS (Eff. 6-1-10) Obtaining and Using Digital Certificates for Electronic Orders § 1311.45 Requirements for registrants that allow powers of attorney to obtain CSOS digital certificates under their DEA...

  19. Data Requirements for Pesticide Registration

    EPA Pesticide Factsheets

    In evaluating a pesticide registration application, we assess a wide variety of potential human health and environmental effects associated with use of the product. Learn about these data requirements.

  20. 40 CFR 161.150 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements § 161.150 General. (a) Applicability. This subpart describes the product chemistry data that are required to support the registration...

  1. 40 CFR 161.150 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements § 161.150 General. (a) Applicability. This subpart describes the product chemistry data that are required to support the registration...

  2. 21 CFR 1311.45 - Requirements for registrants that allow powers of attorney to obtain CSOS digital certificates...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... attorney to obtain CSOS digital certificates under their DEA registration. 1311.45 Section 1311.45 Food and... registrants that allow powers of attorney to obtain CSOS digital certificates under their DEA registration. (a) A registrant that grants power of attorney must report to the DEA Certification Authority within 6...

  3. 14 CFR 135.25 - Aircraft requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... registration and meets the registration and identification requirements of that country; (2) The aircraft is of... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aircraft requirements. 135.25 Section 135... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT General...

  4. 14 CFR 135.25 - Aircraft requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... registration and meets the registration and identification requirements of that country; (2) The aircraft is of... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Aircraft requirements. 135.25 Section 135... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT General...

  5. 14 CFR 135.25 - Aircraft requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... registration and meets the registration and identification requirements of that country; (2) The aircraft is of... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aircraft requirements. 135.25 Section 135... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT General...

  6. 14 CFR 135.25 - Aircraft requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... registration and meets the registration and identification requirements of that country; (2) The aircraft is of... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aircraft requirements. 135.25 Section 135... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT General...

  7. 14 CFR 135.25 - Aircraft requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... registration and meets the registration and identification requirements of that country; (2) The aircraft is of... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aircraft requirements. 135.25 Section 135... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT General...

  8. Direct endoscopic video registration for sinus surgery

    NASA Astrophysics Data System (ADS)

    Mirota, Daniel; Taylor, Russell H.; Ishii, Masaru; Hager, Gregory D.

    2009-02-01

    Advances in computer vision have made possible robust 3D reconstruction of monocular endoscopic video. These reconstructions accurately represent the visible anatomy and, once registered to pre-operative CT data, enable a navigation system to track directly through video eliminating the need for an external tracking system. Video registration provides the means for a direct interface between an endoscope and a navigation system and allows a shorter chain of rigid-body transformations to be used to solve the patient/navigation-system registration. To solve this registration step we propose a new 3D-3D registration algorithm based on Trimmed Iterative Closest Point (TrICP)1 and the z-buffer algorithm.2 The algorithm takes as input a 3D point cloud of relative scale with the origin at the camera center, an isosurface from the CT, and an initial guess of the scale and location. Our algorithm utilizes only the visible polygons of the isosurface from the current camera location during each iteration to minimize the search area of the target region and robustly reject outliers of the reconstruction. We present example registrations in the sinus passage applicable to both sinus surgery and transnasal surgery. To evaluate our algorithm's performance we compare it to registration via Optotrak and present closest distance point to surface error. We show our algorithm has a mean closest distance error of .2268mm.

  9. 40 CFR 79.23 - Registration.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.23 Registration. (a) If the... additive which includes all of the information and assurances required by § 79.21 and has satisfactorily... the fuel additive and notify the fuel manufacturer of such registration. (b) The Administrator shall...

  10. 40 CFR 79.23 - Registration.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.23 Registration. (a) If the... additive which includes all of the information and assurances required by § 79.21 and has satisfactorily... the fuel additive and notify the fuel manufacturer of such registration. (b) The Administrator shall...

  11. 40 CFR 79.23 - Registration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.23 Registration. (a) If the... additive which includes all of the information and assurances required by § 79.21 and has satisfactorily... the fuel additive and notify the fuel manufacturer of such registration. (b) The Administrator shall...

  12. 40 CFR 79.23 - Registration.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.23 Registration. (a) If the... additive which includes all of the information and assurances required by § 79.21 and has satisfactorily... the fuel additive and notify the fuel manufacturer of such registration. (b) The Administrator shall...

  13. 40 CFR 79.23 - Registration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF FUELS AND FUEL ADDITIVES Additive Registration Procedures § 79.23 Registration. (a) If the... additive which includes all of the information and assurances required by § 79.21 and has satisfactorily... the fuel additive and notify the fuel manufacturer of such registration. (b) The Administrator shall...

  14. 76 FR 73564 - Federal Acquisition Regulation; Updates to Contract Reporting and Central Contractor Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... Federal Acquisition Regulation; Updates to Contract Reporting and Central Contractor Registration AGENCIES... Procurement Data System (FPDS). Additionally, changes are proposed for the clauses requiring contractor registration in the Central Contractor Registration (CCR) database and DUNS number reporting. DATES: Interested...

  15. 14 CFR 47.63 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGISTRATION Dealers' Aircraft Registration Certificate § 47.63 Application. A manufacturer or dealer that wishes to obtain a Dealer's Aircraft Registration Certificate, AC Form 8050-6, must submit— (a) A Dealer's Aircraft Registration Certificate Application, AC Form 8050-5; and (b) The fee required by § 47.17...

  16. 14 CFR 47.63 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGISTRATION Dealers' Aircraft Registration Certificate § 47.63 Application. A manufacturer or dealer that wishes to obtain a Dealer's Aircraft Registration Certificate, AC Form 8050-6, must submit— (a) A Dealer's Aircraft Registration Certificate Application, AC Form 8050-5; and (b) The fee required by § 47.17...

  17. 8 CFR 264.1 - Registration and fingerprinting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Security, providing fingerprints, photographs, or submitting supplemental information or documentation. (ii... may be required and each change of material fact is a registration that is required under sections 262...

  18. 8 CFR 264.1 - Registration and fingerprinting.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Security, providing fingerprints, photographs, or submitting supplemental information or documentation. (ii... may be required and each change of material fact is a registration that is required under sections 262...

  19. 21 CFR 1311.130 - Requirements for establishing logical access control-Institutional practitioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... applicable, individual practitioner's DEA registration expires, unless the registration has been renewed. (3) The institutional practitioner's or, where applicable, individual practitioner's DEA registration is...

  20. Preparing registrants for mentor roles: the chicken or egg conundrum.

    PubMed

    McGuinness, Claire; McCallum, Jacqueline; Duffy, Kathleen

    2016-12-01

    The Nursing and Midwifery Council's (NMC) Standards to Support Learning and Assessment in Practice ( 2008 ) outline requirements for the preparation of those who support nursing and midwifery pre-registration students in practice, formally known as mentors. Pre-registration nursing and midwifery programme providers, and practice learning environments (PLEs), work collaboratively to prepare registrants to undertake this role, and to help them maintain mentor status. An important NMC requirement is that registrants, when undertaking mentor preparation programmes, must be supported by experienced mentors in their workplace. This is challenging for programme providers and PLEs if there is lack of experienced mentors in the area concerned. This article discusses support for registrants when preparing to become mentors, suggests some alternative solutions and makes recommendations for the future of mentor preparation in the UK.

  1. Meta-analysis of aquatic chronic chemical toxicity data

    EPA Science Inventory

    Chronic toxicity data from the open literature and from tests submitted for pesticide registration were extracted and assembled into a database, AquaChronTox, with a flexible search interface. Data were captured at a treatment and, when available, replicate level to support conc...

  2. 8 CFR 264.1 - Registration and finger-printing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Security, providing fingerprints, photographs, or submitting supplemental information or documentation. (ii... may be required and each change of material fact is a registration that is required under sections 262...

  3. DOIDB: Reusing DataCite's search software as metadata portal for GFZ Data Services

    NASA Astrophysics Data System (ADS)

    Elger, K.; Ulbricht, D.; Bertelmann, R.

    2016-12-01

    GFZ Data Services is the central service point for the publication of research data at the Helmholtz Centre Potsdam GFZ German Research Centre for Geosciences (GFZ). It provides data publishing services to scientists of GFZ, associated projects, and associated institutions. The publishing services aim to make research data and physical samples visible and citable, by assigning persistent identifiers (DOI, IGSN) and by complementing existing IT infrastructure. To integrate several research domains a modular software stack that is made of free software components has been created to manage data and metadata as well as register persistent identifiers [1]. Pivotal component for the registration of DOIs is the DOIDB. It has been derived from three software components provided by DataCite [2] that moderate the registration of DOIs and the deposition of metadata, allow the dissemination of metadata, and provide a user interface to navigate and discover datasets. The DOIDB acts as a proxy to the DataCite infrastructure and in addition to the DataCite metadata schema, it allows to deposit and disseminate metadata following the schemas ISO19139 and NASA GCMD DIF. The search component has been modified to meet the requirements of a geosciences metadata portal. In particular, the search component has been altered to make use of Apache SOLRs capability to index and query spatial coordinates. Furthermore, the user interface has been adjusted to provide a first impression of the data by showing a map, summary information and subjects. DOIDB and its components are available on GitHub [3].We present a software solution for registration of DOIs that allows to integrate existing data systems, keeps track of registered DOIs, and provides a metadata portal to discover datasets [4]. [1] Ulbricht, D.; Elger, K.; Bertelmann, R.; Klump, J. panMetaDocs, eSciDoc, and DOIDB—An Infrastructure for the Curation and Publication of File-Based Datasets for GFZ Data Services. ISPRS Int. J. Geo-Inf. 2016, 5, 25. http://doi.org/10.3390/ijgi5030025[2] https://github.com/datacite[3] https://github.com/ulbricht/search/tree/doidb , https://github.com/ulbricht/mds/tree/doidb , https://github.com/ulbricht/oaip/tree/doidb[4] http://doidb.wdc-terra.org

  4. 28 CFR 811.9 - Periodic verification of registration information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.9 Periodic verification of registration information. (a) Sex offenders who are required to register for life must verify registration information quarterly pursuant to the procedures set forth in paragraph (d) of this section. (b) All other sex offenders...

  5. 28 CFR 811.9 - Periodic verification of registration information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.9 Periodic verification of registration information. (a) Sex offenders who are required to register for life must verify registration information quarterly pursuant to the procedures set forth in paragraph (d) of this section. (b) All other sex offenders...

  6. 28 CFR 811.9 - Periodic verification of registration information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.9 Periodic verification of registration information. (a) Sex offenders who are required to register for life must verify registration information quarterly pursuant to the procedures set forth in paragraph (d) of this section. (b) All other sex offenders...

  7. 28 CFR 811.9 - Periodic verification of registration information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.9 Periodic verification of registration information. (a) Sex offenders who are required to register for life must verify registration information quarterly pursuant to the procedures set forth in paragraph (d) of this section. (b) All other sex offenders...

  8. 28 CFR 811.9 - Periodic verification of registration information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.9 Periodic verification of registration information. (a) Sex offenders who are required to register for life must verify registration information quarterly pursuant to the procedures set forth in paragraph (d) of this section. (b) All other sex offenders...

  9. 47 CFR 64.615 - TRS User Registration Database and administrator.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false TRS User Registration Database and... Registration Database and administrator. (a) TRS User Registration Database. (1) VRS providers shall validate... Database on a per-call basis. Emergency 911 calls are excepted from this requirement. (i) Validation shall...

  10. 47 CFR 64.615 - TRS User Registration Database and administrator.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false TRS User Registration Database and... Registration Database and administrator. (a) TRS User Registration Database. (1) VRS providers shall validate... Database on a per-call basis. Emergency 911 calls are excepted from this requirement. (i) Validation shall...

  11. 75 FR 43166 - Information Collection; OMB Control No. 3090-00XX; FSRS Registration and Prime Awardee Entity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... ``Information Collection 3090-XXXX, FSRS Registration and Prime Awardee Entity- Related Information [[Page 43167... ``Submit a Comment'' that corresponds with ``Information Collection 3090-XXXX, FSRS Registration and Prime... 3090-XXXX, FSRS Registration and Prime Awardee Entity- Related Information Reporting Requirements'' on...

  12. 37 CFR 1.293 - Statutory invention registration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the date of publication of the statutory invention registration; (2) The required fee for filing a request for publication of a statutory invention registration as provided for in § 1.17 (n) or (o); (3) A... application. (b) Any request for publication of a statutory invention registration must include the following...

  13. 77 FR 69715 - Federal Acquisition Regulation; Updates to Contract Reporting and Central Contractor Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... Contractor Registration AGENCY: Department of Defense (DoD), General Services Administration (GSA), and... changes the clauses requiring contractor registration in the Central Contractor Registration (CCR... unique identifier for contractors. It is used (1) to uniquely identify a contractor entity, and (2) to...

  14. 14 CFR 103.7 - Certification and registration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... registration. (a) Notwithstanding any other section pertaining to certification of aircraft or their parts or... registration and marking of aircraft, ultralight vehicles are not required to be registered or to bear markings... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Certification and registration. 103.7...

  15. 14 CFR 103.7 - Certification and registration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... registration. (a) Notwithstanding any other section pertaining to certification of aircraft or their parts or... registration and marking of aircraft, ultralight vehicles are not required to be registered or to bear markings... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Certification and registration. 103.7...

  16. 14 CFR 103.7 - Certification and registration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... registration. (a) Notwithstanding any other section pertaining to certification of aircraft or their parts or... registration and marking of aircraft, ultralight vehicles are not required to be registered or to bear markings... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Certification and registration. 103.7...

  17. Technologies and practices for maintaining and publishing earth science vocabularies

    NASA Astrophysics Data System (ADS)

    Cox, Simon; Yu, Jonathan; Williams, Megan; Giabardo, Fabrizio; Lowe, Dominic

    2015-04-01

    Shared vocabularies are a key element in geoscience data interoperability. Many organizations curate vocabularies, with most Geologic Surveys having a long history of development of lexicons and authority tables. However, their mode of publication is heterogeneous, ranging from PDFs and HTML web pages, spreadsheets and CSV, through various user-interfaces, and public and private APIs. Content maintenance ranges from tightly-governed and externally opaque, through various community processes, all the way to crowd-sourcing ('folksonomies'). Meanwhile, there is an increasing expectation of greater harmonization and vocabulary re-use, which create requirements for standardized content formalization and APIs, along with transparent content maintenance and versioning. We have been trialling a combination of processes and software dealing with vocabulary formalization, registration, search and linking. We use the Simplified Knowledge Organization System (SKOS) to provide a generic interface to content. SKOS is an RDF technology for multi-lingual, hierarchical vocabularies, oriented around 'concepts' denoted by URIs, and thus consistent with Linked Open Data. SKOS may be mixed in with classes and properties from specialized ontologies which provide a more specific interface when required. We have developed a suite of practices and techniques for conversion of content from the source technologies and styles into SKOS, largely based on spreadsheet manipulation before RDF conversion, and SPARQL afterwards. The workflow for each vocabulary must be adapted to match the specific inputs. In linked data applications, two requirements are paramount for user confidence: (i) the URI that denotes a vocabulary item is persistent, and should be dereferenceable indefinitely; (ii) the history and status of the resource denoted by a URI must be available. This is implemented by the Linked Data Registry (LDR), originally developed for the World Meteorological Organization and the UK Environment Agency, and now adapted and enhanced for deployment by CSIRO and the Australian Bureau of Meteorology. The LDR applies a standard content registration paradigm to RDF data, also including a delegation mode that enables a system to register (endorse) externally managed content. The locally managed RDF is exposed on a SPARQL endpoint. The registry implementation enables a flexible interaction pattern to support various specific content publication workflows, with the key feature of making the content externally accessible through a standard interface alongside its history, previous versions, and status. SPARQL is the standard low-level API for RDF including SKOS. On top of this we have developed SISSvoc, a SKOS-based RESTful API. This has been used it to deploy a number of vocabularies on behalf of the IUGS, ICS, NERC, OGC, the Australian Government, and CSIRO projects. Applications like SISSvoc Search provide a simple search UI on top of one or more SISSvoc sources. Together, these components provide a powerful and flexible system for providing earth science vocabularies for the community, consistent with semantic web and linked-data principles.

  18. Automatic image fusion of real-time ultrasound with computed tomography images: a prospective comparison between two auto-registration methods.

    PubMed

    Cha, Dong Ik; Lee, Min Woo; Kim, Ah Yeong; Kang, Tae Wook; Oh, Young-Taek; Jeong, Ja-Yeon; Chang, Jung-Woo; Ryu, Jiwon; Lee, Kyong Joon; Kim, Jaeil; Bang, Won-Chul; Shin, Dong Kuk; Choi, Sung Jin; Koh, Dalkwon; Seo, Bong Koo; Kim, Kyunga

    2017-11-01

    Background A major drawback of conventional manual image fusion is that the process may be complex, especially for less-experienced operators. Recently, two automatic image fusion techniques called Positioning and Sweeping auto-registration have been developed. Purpose To compare the accuracy and required time for image fusion of real-time ultrasonography (US) and computed tomography (CT) images between Positioning and Sweeping auto-registration. Material and Methods Eighteen consecutive patients referred for planning US for radiofrequency ablation or biopsy for focal hepatic lesions were enrolled. Image fusion using both auto-registration methods was performed for each patient. Registration error, time required for image fusion, and number of point locks used were compared using the Wilcoxon signed rank test. Results Image fusion was successful in all patients. Positioning auto-registration was significantly faster than Sweeping auto-registration for both initial (median, 11 s [range, 3-16 s] vs. 32 s [range, 21-38 s]; P < 0.001] and complete (median, 34.0 s [range, 26-66 s] vs. 47.5 s [range, 32-90]; P = 0.001] image fusion. Registration error of Positioning auto-registration was significantly higher for initial image fusion (median, 38.8 mm [range, 16.0-84.6 mm] vs. 18.2 mm [6.7-73.4 mm]; P = 0.029), but not for complete image fusion (median, 4.75 mm [range, 1.7-9.9 mm] vs. 5.8 mm [range, 2.0-13.0 mm]; P = 0.338]. Number of point locks required to refine the initially fused images was significantly higher with Positioning auto-registration (median, 2 [range, 2-3] vs. 1 [range, 1-2]; P = 0.012]. Conclusion Positioning auto-registration offers faster image fusion between real-time US and pre-procedural CT images than Sweeping auto-registration. The final registration error is similar between the two methods.

  19. Registration of segmented histological images using thin plate splines and belief propagation

    NASA Astrophysics Data System (ADS)

    Kybic, Jan

    2014-03-01

    We register images based on their multiclass segmentations, for cases when correspondence of local features cannot be established. A discrete mutual information is used as a similarity criterion. It is evaluated at a sparse set of location on the interfaces between classes. A thin-plate spline regularization is approximated by pairwise interactions. The problem is cast into a discrete setting and solved efficiently by belief propagation. Further speedup and robustness is provided by a multiresolution framework. Preliminary experiments suggest that our method can provide similar registration quality to standard methods at a fraction of the computational cost.

  20. 21 CFR 1301.11 - Persons required to register; requirement of modification of registration authorizing activity as...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... modification of registration authorizing activity as an online pharmacy. 1301.11 Section 1301.11 Food and Drugs... modification of registration authorizing activity as an online pharmacy. (a) Every person who manufactures... “online pharmacy” (as set forth in section 102(52) of the Act (21 U.S.C. 802(52)) and § 1300.04(h) of this...

  1. 21 CFR 1301.11 - Persons required to register; requirement of modification of registration authorizing activity as...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... modification of registration authorizing activity as an online pharmacy. 1301.11 Section 1301.11 Food and Drugs... modification of registration authorizing activity as an online pharmacy. (a) Every person who manufactures... “online pharmacy” (as set forth in section 102(52) of the Act (21 U.S.C. 802(52)) and § 1300.04(h) of this...

  2. 21 CFR 1301.11 - Persons required to register; requirement of modification of registration authorizing activity as...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... modification of registration authorizing activity as an online pharmacy. 1301.11 Section 1301.11 Food and Drugs... modification of registration authorizing activity as an online pharmacy. (a) Every person who manufactures... “online pharmacy” (as set forth in section 102(52) of the Act (21 U.S.C. 802(52)) and § 1300.04(h) of this...

  3. 21 CFR 1301.11 - Persons required to register; requirement of modification of registration authorizing activity as...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... modification of registration authorizing activity as an online pharmacy. 1301.11 Section 1301.11 Food and Drugs... modification of registration authorizing activity as an online pharmacy. (a) Every person who manufactures... “online pharmacy” (as set forth in section 102(52) of the Act (21 U.S.C. 802(52)) and § 1300.04(h) of this...

  4. 21 CFR 1301.11 - Persons required to register; requirement of modification of registration authorizing activity as...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... modification of registration authorizing activity as an online pharmacy. 1301.11 Section 1301.11 Food and Drugs... modification of registration authorizing activity as an online pharmacy. (a) Every person who manufactures... “online pharmacy” (as set forth in section 102(52) of the Act (21 U.S.C. 802(52)) and § 1300.04(h) of this...

  5. Symposium Registration | The Metastatic Niche: Models, Mechanisms and Targeting Targets into Therapeutics

    Cancer.gov

    Symposium Registration Register for the meeting and abstract submission. Registration for the meeting is required and registration is free. ONLINE REGISTRATION IS CLOSED. Please contact Julia E. Lam (Julia.Lam@nih.gov) if you want to register to attend this event. Abstracts should be submitted at the time of registration and a limited number will be selected for oral presentation and the remainder for poster presentation.   Abstract Submission Deadline is February 21st 2017.

  6. Supervised local error estimation for nonlinear image registration using convolutional neural networks

    NASA Astrophysics Data System (ADS)

    Eppenhof, Koen A. J.; Pluim, Josien P. W.

    2017-02-01

    Error estimation in medical image registration is valuable when validating, comparing, or combining registration methods. To validate a nonlinear image registration method, ideally the registration error should be known for the entire image domain. We propose a supervised method for the estimation of a registration error map for nonlinear image registration. The method is based on a convolutional neural network that estimates the norm of the residual deformation from patches around each pixel in two registered images. This norm is interpreted as the registration error, and is defined for every pixel in the image domain. The network is trained using a set of artificially deformed images. Each training example is a pair of images: the original image, and a random deformation of that image. No manually labeled ground truth error is required. At test time, only the two registered images are required as input. We train and validate the network on registrations in a set of 2D digital subtraction angiography sequences, such that errors up to eight pixels can be estimated. We show that for this range of errors the convolutional network is able to learn the registration error in pairs of 2D registered images at subpixel precision. Finally, we present a proof of principle for the extension to 3D registration problems in chest CTs, showing that the method has the potential to estimate errors in 3D registration problems.

  7. [Discussion on Technical Evaluation for Medical Device Registration Material].

    PubMed

    Chu, Yungao; Qian, Hong; Zhu, Yingfeng

    2017-07-30

    This article first introduces the main contents of the requirements for medical device registration. Secondly, this article chooses the vertebral forming surgery system as an example to discuss the technical evaluation for the registration research material. The article hopes to provide a reference for the applicant who prepare the registration material and the technical evaluator who make the evaluation for the medical device registration.

  8. 75 FR 76260 - Conforming Changes to Applicant Submission Requirements; Implementing Federal Financial Report...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-08

    ... Report and Central Contractor Registration Requirements AGENCY: Office of the Secretary, HUD. ACTION... that applicants for HUD assistance possess an active Central Contractor Registration (CCR). HUD is...

  9. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... supplemental statement at intervals of 6 months for the duration of the principal-agent relationship requiring registration. (b) The initial statement shall be filed on a form provided by the Registration Unit. (28 U.S.C...

  10. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... supplemental statement at intervals of 6 months for the duration of the principal-agent relationship requiring registration. (b) The initial statement shall be filed on a form provided by the Registration Unit. (28 U.S.C...

  11. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... supplemental statement at intervals of 6 months for the duration of the principal-agent relationship requiring registration. (b) The initial statement shall be filed on a form provided by the Registration Unit. (28 U.S.C...

  12. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... supplemental statement at intervals of 6 months for the duration of the principal-agent relationship requiring registration. (b) The initial statement shall be filed on a form provided by the Registration Unit. (28 U.S.C...

  13. 28 CFR 5.200 - Registration.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... supplemental statement at intervals of 6 months for the duration of the principal-agent relationship requiring registration. (b) The initial statement shall be filed on a form provided by the Registration Unit. (28 U.S.C...

  14. Alternative Fuels Data Center

    Science.gov Websites

    Registration Fee Battery electric vehicle owners are required to pay an additional registration fee registration fee of $50. The Indiana Bureau of Motor Vehicles will determine new fee amounts every five years

  15. Fuels Registration, Reporting, and Compliance Help

    EPA Pesticide Factsheets

    Information about the requirements for registration and health effects testing of new fuels or fuel additives and mandatory registration for fuels reporting and about mandatory reporting forms for parties regulated under EPA fuel programs.

  16. USDA registration and rectification requirements

    NASA Technical Reports Server (NTRS)

    Allen, R.

    1982-01-01

    Some of the requirements of the United States Department of Agriculture for accuracy of aerospace acquired data, and specifically, requirements for registration and rectification of remotely sensed data are discussed. Particular attention is given to foreign and domestic crop estimation and forecasting, forestry information applications, and rangeland condition evaluations.

  17. 28 CFR 72.3 - Applicability of the Sex Offender Registration and Notification Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Applicability of the Sex Offender...) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.3 Applicability of the Sex Offender Registration and Notification Act. The requirements of the Sex Offender Registration and Notification Act apply to all sex...

  18. 28 CFR 72.3 - Applicability of the Sex Offender Registration and Notification Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Applicability of the Sex Offender...) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.3 Applicability of the Sex Offender Registration and Notification Act. The requirements of the Sex Offender Registration and Notification Act apply to all sex...

  19. 28 CFR 72.3 - Applicability of the Sex Offender Registration and Notification Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Applicability of the Sex Offender...) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.3 Applicability of the Sex Offender Registration and Notification Act. The requirements of the Sex Offender Registration and Notification Act apply to all sex...

  20. 28 CFR 72.3 - Applicability of the Sex Offender Registration and Notification Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Applicability of the Sex Offender...) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.3 Applicability of the Sex Offender Registration and Notification Act. The requirements of the Sex Offender Registration and Notification Act apply to all sex...

  1. 28 CFR 72.3 - Applicability of the Sex Offender Registration and Notification Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Applicability of the Sex Offender...) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.3 Applicability of the Sex Offender Registration and Notification Act. The requirements of the Sex Offender Registration and Notification Act apply to all sex...

  2. 28 CFR 5.206 - Language and wording of registration statement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Language and wording of registration... OF FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.206 Language and wording of registration... required to be filed under the Act shall be submitted in the English language. An exhibit may be filed even...

  3. Influence of image registration on ADC images computed from free-breathing diffusion MRIs of the abdomen

    NASA Astrophysics Data System (ADS)

    Guyader, Jean-Marie; Bernardin, Livia; Douglas, Naomi H. M.; Poot, Dirk H. J.; Niessen, Wiro J.; Klein, Stefan

    2014-03-01

    The apparent diffusion coefficient (ADC) is an imaging biomarker providing quantitative information on the diffusion of water in biological tissues. This measurement could be of relevance in oncology drug development, but it suffers from a lack of reliability. ADC images are computed by applying a voxelwise exponential fitting to multiple diffusion-weighted MR images (DW-MRIs) acquired with different diffusion gradients. In the abdomen, respiratory motion induces misalignments in the datasets, creating visible artefacts and inducing errors in the ADC maps. We propose a multistep post-acquisition motion compensation pipeline based on 3D non-rigid registrations. It corrects for motion within each image and brings all DW-MRIs to a common image space. The method is evaluated on 10 datasets of free-breathing abdominal DW-MRIs acquired from healthy volunteers. Regions of interest (ROIs) are segmented in the right part of the abdomen and measurements are compared in the three following cases: no image processing, Gaussian blurring of the raw DW-MRIs and registration. Results show that both blurring and registration improve the visual quality of ADC images, but compared to blurring, registration yields visually sharper images. Measurement uncertainty is reduced both by registration and blurring. For homogeneous ROIs, blurring and registration result in similar median ADCs, which are lower than without processing. In a ROI at the interface between liver and kidney, registration and blurring yield different median ADCs, suggesting that uncorrected motion introduces a bias. Our work indicates that averaging procedures on the scanner should be avoided, as they remove the opportunity to perform motion correction.

  4. Automated Student Aid Processing: The Challenge and Opportunity.

    ERIC Educational Resources Information Center

    St. John, Edward P.

    1985-01-01

    To utilize automated technology for student aid processing, it is necessary to work with multi-institutional offices (student aid, admissions, registration, and business) and to develop automated interfaces with external processing systems at state and federal agencies and perhaps at need-analysis organizations and lenders. (MLW)

  5. 21 CFR 1301.19 - Special requirements for online pharmacies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Special requirements for online pharmacies. 1301... Special requirements for online pharmacies. (a) A pharmacy that has been issued a registration under § 1301.13 may request that the Administrator modify its registration to authorize the pharmacy to...

  6. 21 CFR 1301.19 - Special requirements for online pharmacies.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Special requirements for online pharmacies. 1301... Special requirements for online pharmacies. (a) A pharmacy that has been issued a registration under § 1301.13 may request that the Administrator modify its registration to authorize the pharmacy to...

  7. 21 CFR 1301.19 - Special requirements for online pharmacies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Special requirements for online pharmacies. 1301... Special requirements for online pharmacies. (a) A pharmacy that has been issued a registration under § 1301.13 may request that the Administrator modify its registration to authorize the pharmacy to...

  8. 21 CFR 1301.19 - Special requirements for online pharmacies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Special requirements for online pharmacies. 1301... Special requirements for online pharmacies. (a) A pharmacy that has been issued a registration under § 1301.13 may request that the Administrator modify its registration to authorize the pharmacy to...

  9. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...; (vi) Travel document type (e.g., P = passport; A = alien registration card); (vii) Passport number, if a passport is required; (viii) Passport country of issuance, if a passport is required; (ix) Passport expiration date, if a passport is required; (x) Alien registration number, where applicable; (xi...

  10. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...; (vi) Travel document type (e.g., P = passport; A = alien registration card); (vii) Passport number, if a passport is required; (viii) Passport country of issuance, if a passport is required; (ix) Passport expiration date, if a passport is required; (x) Alien registration number, where applicable; (xi...

  11. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...; (vi) Travel document type (e.g., P = passport; A = alien registration card); (vii) Passport number, if a passport is required; (viii) Passport country of issuance, if a passport is required; (ix) Passport expiration date, if a passport is required; (x) Alien registration number, where applicable; (xi...

  12. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...; (vi) Travel document type (e.g., P = passport; A = alien registration card); (vii) Passport number, if a passport is required; (viii) Passport country of issuance, if a passport is required; (ix) Passport expiration date, if a passport is required; (x) Alien registration number, where applicable; (xi...

  13. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...; (vi) Travel document type (e.g., P = passport; A = alien registration card); (vii) Passport number, if a passport is required; (viii) Passport country of issuance, if a passport is required; (ix) Passport expiration date, if a passport is required; (x) Alien registration number, where applicable; (xi...

  14. 77 FR 1935 - Information Collection Being Reviewed by the Federal Communications Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ...-0645. Title: Sections 17.4, 17.48 and 17.49, Antenna Structure Registration Requirements. Form Number... uniform registration process as well as safe and effective lighting procedures for owners of antenna structures. Section 17.4 requires the owner of any proposed or existing antenna structure that requires...

  15. 40 CFR 161.202 - Purposes of the registration data requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... fate studies are used to: assess the toxicity to man through exposure of humans to pesticide residues... for humans, fish and wildlife, or plants are used to assess the potential hazard of pesticides to...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Data Requirement Tables...

  16. 40 CFR 161.202 - Purposes of the registration data requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fate studies are used to: assess the toxicity to man through exposure of humans to pesticide residues... for humans, fish and wildlife, or plants are used to assess the potential hazard of pesticides to...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Data Requirement Tables...

  17. 40 CFR 161.202 - Purposes of the registration data requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... fate studies are used to: assess the toxicity to man through exposure of humans to pesticide residues... for humans, fish and wildlife, or plants are used to assess the potential hazard of pesticides to...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Data Requirement Tables...

  18. 40 CFR 161.202 - Purposes of the registration data requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... fate studies are used to: assess the toxicity to man through exposure of humans to pesticide residues... for humans, fish and wildlife, or plants are used to assess the potential hazard of pesticides to...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Data Requirement Tables...

  19. A novel graphical user interface for ultrasound-guided shoulder arthroscopic surgery

    NASA Astrophysics Data System (ADS)

    Tyryshkin, K.; Mousavi, P.; Beek, M.; Pichora, D.; Abolmaesumi, P.

    2007-03-01

    This paper presents a novel graphical user interface developed for a navigation system for ultrasound-guided computer-assisted shoulder arthroscopic surgery. The envisioned purpose of the interface is to assist the surgeon in determining the position and orientation of the arthroscopic camera and other surgical tools within the anatomy of the patient. The user interface features real time position tracking of the arthroscopic instruments with an optical tracking system, and visualization of their graphical representations relative to a three-dimensional shoulder surface model of the patient, created from computed tomography images. In addition, the developed graphical interface facilitates fast and user-friendly intra-operative calibration of the arthroscope and the arthroscopic burr, capture and segmentation of ultrasound images, and intra-operative registration. A pilot study simulating the computer-aided shoulder arthroscopic procedure on a shoulder phantom demonstrated the speed, efficiency and ease-of-use of the system.

  20. Local-search based prediction of medical image registration error

    NASA Astrophysics Data System (ADS)

    Saygili, Görkem

    2018-03-01

    Medical image registration is a crucial task in many different medical imaging applications. Hence, considerable amount of work has been published recently that aim to predict the error in a registration without any human effort. If provided, these error predictions can be used as a feedback to the registration algorithm to further improve its performance. Recent methods generally start with extracting image-based and deformation-based features, then apply feature pooling and finally train a Random Forest (RF) regressor to predict the real registration error. Image-based features can be calculated after applying a single registration but provide limited accuracy whereas deformation-based features such as variation of deformation vector field may require up to 20 registrations which is a considerably high time-consuming task. This paper proposes to use extracted features from a local search algorithm as image-based features to estimate the error of a registration. The proposed method comprises a local search algorithm to find corresponding voxels between registered image pairs and based on the amount of shifts and stereo confidence measures, it predicts the amount of registration error in millimetres densely using a RF regressor. Compared to other algorithms in the literature, the proposed algorithm does not require multiple registrations, can be efficiently implemented on a Graphical Processing Unit (GPU) and can still provide highly accurate error predictions in existence of large registration error. Experimental results with real registrations on a public dataset indicate a substantially high accuracy achieved by using features from the local search algorithm.

  1. Standard formatted data units-control authority procedures

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The purpose of this document is to establish a set of minimum and optional requirements for the implementation of Control Authority (CA) organizations within and among the Agencies participating in the Consultative Committee for Space Data Systems (CCSDS). By satisfying these requirements, the resultant cooperating set of CA organizations will produce a global CA service supporting information transfer with digital data under the Standard Formatted Data Unit (SFDU) concept. This service is primarily accomplished through the registration, permanent archiving, and dissemination of metadata in the form of Metadata Objects (MDO) that assist in the interpretation of data objects received in SFDU form. This Recommendation addresses the responsibilities, services, and interface protocols for a hierarchy of CA organizations. The top level, consisting of the CCSDS Secretariat and its operational agent, is unique and primarily provides a global coordination function. The lower levels are Agency CA organizations that have primary responsibility for the registration, archiving, and dissemination of MDOs. As experience is gained and technology evolves, the CA Procedures will be extended to include enhanced services and their supporting protocols. In particular, it is anticipated that eventually CA organizations will be linked via networks on a global basis, and will provide requestors with online automated access to CA services. While this Recommendation does not preclude such operations, it also does not recommend the specific protocols to be used to ensure global compatibility of these services. These recommendations will be generated as experience is gained.

  2. Recommendations for a service framework to access astronomical archives

    NASA Technical Reports Server (NTRS)

    Travisano, J. J.; Pollizzi, J.

    1992-01-01

    There are a large number of astronomical archives and catalogs on-line for network access, with many different user interfaces and features. Some systems are moving towards distributed access, supplying users with client software for their home sites which connects to servers at the archive site. Many of the issues involved in defining a standard framework of services that archive/catalog suppliers can use to achieve a basic level of interoperability are described. Such a framework would simplify the development of client and server programs to access the wide variety of astronomical archive systems. The primary services that are supplied by current systems include: catalog browsing, dataset retrieval, name resolution, and data analysis. The following issues (and probably more) need to be considered in establishing a standard set of client/server interfaces and protocols: Archive Access - dataset retrieval, delivery, file formats, data browsing, analysis, etc.; Catalog Access - database management systems, query languages, data formats, synchronous/asynchronous mode of operation, etc.; Interoperability - transaction/message protocols, distributed processing mechanisms (DCE, ONC/SunRPC, etc), networking protocols, etc.; Security - user registration, authorization/authentication mechanisms, etc.; Service Directory - service registration, lookup, port/task mapping, parameters, etc.; Software - public vs proprietary, client/server software, standard interfaces to client/server functions, software distribution, operating system portability, data portability, etc. Several archive/catalog groups, notably the Astrophysics Data System (ADS), are already working in many of these areas. In the process of developing StarView, which is the user interface to the Space Telescope Data Archive and Distribution Service (ST-DADS), these issues and the work of others were analyzed. A framework of standard interfaces for accessing services on any archive system which would benefit archive user and supplier alike is proposed.

  3. A usability evaluation of a SNOMED CT based compositional interface terminology for intensive care.

    PubMed

    Bakhshi-Raiez, F; de Keizer, N F; Cornet, R; Dorrepaal, M; Dongelmans, D; Jaspers, M W M

    2012-05-01

    To evaluate the usability of a large compositional interface terminology based on SNOMED CT and the terminology application for registration of the reasons for intensive care admission in a Patient Data Management System. Observational study with user-based usability evaluations before and 3 months after the system was implemented and routinely used. Usability was defined by five aspects: effectiveness, efficiency, learnability, overall user satisfaction, and experienced usability problems. Qualitative (the Think-Aloud user testing method) and quantitative (the System Usability Scale questionnaire and Time-on-Task analyses) methods were used to examine these usability aspects. The results of the evaluation study revealed that the usability of the interface terminology fell short (SUS scores before and after implementation of 47.2 out of 100 and 37.5 respectively out of 100). The qualitative measurements revealed a high number (n=35) of distinct usability problems, leading to ineffective and inefficient registration of reasons for admission. The effectiveness and efficiency of the system did not change over time. About 14% (n=5) of the revealed usability problems were related to the terminology content based on SNOMED CT, while the remaining 86% (n=30) was related to the terminology application. The problems related to the terminology content were more severe than the problems related to the terminology application. This study provides a detailed insight into how clinicians interact with a controlled compositional terminology through a terminology application. The extensiveness, complexity of the hierarchy, and the language usage of an interface terminology are defining for its usability. Carefully crafted domain-specific subsets and a well-designed terminology application are needed to facilitate the use of a complex compositional interface terminology based on SNOMED CT. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  4. Towards operational multisensor registration

    NASA Technical Reports Server (NTRS)

    Rignot, Eric J. M.; Kwok, Ronald; Curlander, John C.

    1991-01-01

    To use data from a number of different remote sensors in a synergistic manner, a multidimensional analysis of the data is necessary. However, prior to this analysis, processing to correct for the systematic geometric distortion characteristic of each sensor is required. Furthermore, the registration process must be fully automated to handle a large volume of data and high data rates. A conceptual approach towards an operational multisensor registration algorithm is presented. The performance requirements of the algorithm are first formulated given the spatially, temporally, and spectrally varying factors that influence the image characteristics and the science requirements of various applications. Several registration techniques that fit within the structure of this algorithm are also presented. Their performance was evaluated using a multisensor test data set assembled from LANDSAT TM, SEASAT, SIR-B, Thermal Infrared Multispectral Scanner (TIMS), and SPOT sensors.

  5. Review Process for the Registration and Use Directions for Floor Wipe Towelette Products

    EPA Pesticide Factsheets

    This guidance provides Antimicrobials Division staff with guidance related to the registration requirements and use directions for presaturated/impregnated floor wipe towelette products. This document will be used for new and existing wipe registrations.

  6. Vessel network detection using contour evolution and color components

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ushizima, Daniela; Medeiros, Fatima; Cuadros, Jorge

    2011-06-22

    Automated retinal screening relies on vasculature segmentation before the identification of other anatomical structures of the retina. Vasculature extraction can also be input to image quality ranking, neovascularization detection and image registration, among other applications. There is an extensive literature related to this problem, often excluding the inherent heterogeneity of ophthalmic clinical images. The contribution of this paper relies on an algorithm using front propagation to segment the vessel network. The algorithm includes a penalty in the wait queue on the fast marching heap to minimize leakage of the evolving interface. The method requires no manual labeling, a minimum numbermore » of parameters and it is capable of segmenting color ocular fundus images in real scenarios, where multi-ethnicity and brightness variations are parts of the problem.« less

  7. Do emergency medicine journals promote trial registration and adherence to reporting guidelines? A survey of "Instructions for Authors".

    PubMed

    Sims, Matthew T; Henning, Nolan M; Wayant, C Cole; Vassar, Matt

    2016-11-24

    The aim of this study was to evaluate the current state of two publication practices, reporting guidelines requirements and clinical trial registration requirements, by analyzing the "Instructions for Authors" of emergency medicine journals. We performed a web-based data abstraction from the "Instructions for Authors" of the 27 Emergency Medicine journals catalogued in the Expanded Science Citation Index of the 2014 Journal Citation Reports and Google Scholar Metrics h5-index to identify whether each journal required, recommended, or made no mention of the following reporting guidelines: EQUATOR Network, ICMJE, ARRIVE, CARE, CONSORT, STARD, TRIPOD, CHEERS, MOOSE, STROBE, COREQ, SRQR, SQUIRE, PRISMA-P, SPIRIT, PRISMA, and QUOROM. We also extracted whether journals required or recommended trial registration. Authors were blinded to one another's ratings until completion of the data validation. Cross-tabulations and descriptive statistics were calculated using IBM SPSS 22. Of the 27 emergency medicine journals, 11 (11/27, 40.7%) did not mention a single guideline within their "Instructions for Authors," while the remaining 16 (16/27, 59.3%) mentioned one or more guidelines. The QUOROM statement and SRQR were not mentioned by any journals whereas the ICMJE guidelines (18/27, 66.7%) and CONSORT statement (15/27, 55.6%) were mentioned most often. Of the 27 emergency medicine journals, 15 (15/27, 55.6%) did not mention trial or review registration, while the remaining 12 (12/27, 44.4%) at least mentioned one of the two. Trial registration through ClinicalTrials.gov was mentioned by seven (7/27, 25.9%) journals while the WHO registry was mentioned by four (4/27, 14.8%). Twelve (12/27, 44.4%) journals mentioned trial registration through any registry platform. The aim of this study was to evaluate the current state of two publication practices, reporting guidelines requirements and clinical trial registration requirements, by analyzing the "Instructions for Authors" of emergency medicine journals. In this study, there was not a single reporting guideline mentioned in more than half of the journals. This undermines efforts of other journals to improve the completeness and transparency of research reporting. Reporting guidelines are infrequently required or recommended by emergency medicine journals. Furthermore, few require clinical trial registration. These two mechanisms may limit bias and should be considered for adoption by journal editors in emergency medicine. UMIN000022486.

  8. Relational Information Management Data-Base System

    NASA Technical Reports Server (NTRS)

    Storaasli, O. O.; Erickson, W. J.; Gray, F. P.; Comfort, D. L.; Wahlstrom, S. O.; Von Limbach, G.

    1985-01-01

    DBMS with several features particularly useful to scientists and engineers. RIM5 interfaced with any application program written in language capable of Calling FORTRAN routines. Applications include data management for Space Shuttle Columbia tiles, aircraft flight tests, high-pressure piping, atmospheric chemistry, census, university registration, CAD/CAM Geometry, and civil-engineering dam construction.

  9. 77 FR 19015 - Announcement of Requirements and Registration for Beat Down Blood Pressure Challenge

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... Down Blood Pressure Challenge AGENCY: Office of the National Coordinator for Health Information... Register (77 FR 17060) announcing requirements and registration for a Beat Down Blood Pressure Video... you to visit http://BloodPressure.Challenge.gov for a complete set of rules and requirements for this...

  10. 9 CFR 79.5 - Issuance of certificates.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... GOATS § 79.5 Issuance of certificates. (a) Certificates are required as specified by § 79.3 for certain... registered breed association registration tattoo, individual animal registered breed association registration brand, individual animal registered breed association registration number, and any other official...

  11. 9 CFR 79.5 - Issuance of certificates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... GOATS § 79.5 Issuance of certificates. (a) Certificates are required as specified by § 79.3 for certain... registered breed association registration tattoo, individual animal registered breed association registration brand, individual animal registered breed association registration number, and any other official...

  12. 28 CFR 72.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Administration DEPARTMENT OF JUSTICE (CONTINUED) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.1 Purpose. This part specifies the applicability of the requirements of the Sex Offender Registration and Notification Act to sex offenders convicted prior to the enactment of that Act. These requirements include...

  13. 28 CFR 72.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Administration DEPARTMENT OF JUSTICE (CONTINUED) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.1 Purpose. This part specifies the applicability of the requirements of the Sex Offender Registration and Notification Act to sex offenders convicted prior to the enactment of that Act. These requirements include...

  14. 28 CFR 72.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Administration DEPARTMENT OF JUSTICE (CONTINUED) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.1 Purpose. This part specifies the applicability of the requirements of the Sex Offender Registration and Notification Act to sex offenders convicted prior to the enactment of that Act. These requirements include...

  15. 28 CFR 72.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administration DEPARTMENT OF JUSTICE (CONTINUED) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.1 Purpose. This part specifies the applicability of the requirements of the Sex Offender Registration and Notification Act to sex offenders convicted prior to the enactment of that Act. These requirements include...

  16. 28 CFR 72.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Administration DEPARTMENT OF JUSTICE (CONTINUED) SEX OFFENDER REGISTRATION AND NOTIFICATION § 72.1 Purpose. This part specifies the applicability of the requirements of the Sex Offender Registration and Notification Act to sex offenders convicted prior to the enactment of that Act. These requirements include...

  17. 19 CFR 122.27 - Documents required.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    .../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

  18. 19 CFR 122.27 - Documents required.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    .../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

  19. 19 CFR 122.27 - Documents required.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    .../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

  20. 19 CFR 122.27 - Documents required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

  1. 19 CFR 122.27 - Documents required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .../license, certificate of registration—(1) Pilot certificate/license. A commander of a private aircraft... officer. (2) Certificate of registration. A valid certificate of registration for private aircraft which... AIR COMMERCE REGULATIONS Private Aircraft § 122.27 Documents required. (a) Crewmembers and passengers...

  2. Real-time automatic registration in optical surgical navigation

    NASA Astrophysics Data System (ADS)

    Lin, Qinyong; Yang, Rongqian; Cai, Ken; Si, Xuan; Chen, Xiuwen; Wu, Xiaoming

    2016-05-01

    An image-guided surgical navigation system requires the improvement of the patient-to-image registration time to enhance the convenience of the registration procedure. A critical step in achieving this aim is performing a fully automatic patient-to-image registration. This study reports on a design of custom fiducial markers and the performance of a real-time automatic patient-to-image registration method using these markers on the basis of an optical tracking system for rigid anatomy. The custom fiducial markers are designed to be automatically localized in both patient and image spaces. An automatic localization method is performed by registering a point cloud sampled from the three dimensional (3D) pedestal model surface of a fiducial marker to each pedestal of fiducial markers searched in image space. A head phantom is constructed to estimate the performance of the real-time automatic registration method under four fiducial configurations. The head phantom experimental results demonstrate that the real-time automatic registration method is more convenient, rapid, and accurate than the manual method. The time required for each registration is approximately 0.1 s. The automatic localization method precisely localizes the fiducial markers in image space. The averaged target registration error for the four configurations is approximately 0.7 mm. The automatic registration performance is independent of the positions relative to the tracking system and the movement of the patient during the operation.

  3. Multimodal Image Registration through Simultaneous Segmentation.

    PubMed

    Aganj, Iman; Fischl, Bruce

    2017-11-01

    Multimodal image registration facilitates the combination of complementary information from images acquired with different modalities. Most existing methods require computation of the joint histogram of the images, while some perform joint segmentation and registration in alternate iterations. In this work, we introduce a new non-information-theoretical method for pairwise multimodal image registration, in which the error of segmentation - using both images - is considered as the registration cost function. We empirically evaluate our method via rigid registration of multi-contrast brain magnetic resonance images, and demonstrate an often higher registration accuracy in the results produced by the proposed technique, compared to those by several existing methods.

  4. 78 FR 23835 - Sex Offender Registration Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ... 3225-AA10 Sex Offender Registration Amendments AGENCY: Court Services and Offender Supervision Agency... and requirements relating to periodic verification of registration information for sex offenders. Furthermore, the rule permits CSOSA to verify addresses of sex offenders by conducting home visits on its own...

  5. Software components for medical image visualization and surgical planning

    NASA Astrophysics Data System (ADS)

    Starreveld, Yves P.; Gobbi, David G.; Finnis, Kirk; Peters, Terence M.

    2001-05-01

    Purpose: The development of new applications in medical image visualization and surgical planning requires the completion of many common tasks such as image reading and re-sampling, segmentation, volume rendering, and surface display. Intra-operative use requires an interface to a tracking system and image registration, and the application requires basic, easy to understand user interface components. Rapid changes in computer and end-application hardware, as well as in operating systems and network environments make it desirable to have a hardware and operating system as an independent collection of reusable software components that can be assembled rapidly to prototype new applications. Methods: Using the OpenGL based Visualization Toolkit as a base, we have developed a set of components that implement the above mentioned tasks. The components are written in both C++ and Python, but all are accessible from Python, a byte compiled scripting language. The components have been used on the Red Hat Linux, Silicon Graphics Iris, Microsoft Windows, and Apple OS X platforms. Rigorous object-oriented software design methods have been applied to ensure hardware independence and a standard application programming interface (API). There are components to acquire, display, and register images from MRI, MRA, CT, Computed Rotational Angiography (CRA), Digital Subtraction Angiography (DSA), 2D and 3D ultrasound, video and physiological recordings. Interfaces to various tracking systems for intra-operative use have also been implemented. Results: The described components have been implemented and tested. To date they have been used to create image manipulation and viewing tools, a deep brain functional atlas, a 3D ultrasound acquisition and display platform, a prototype minimally invasive robotic coronary artery bypass graft planning system, a tracked neuro-endoscope guidance system and a frame-based stereotaxy neurosurgery planning tool. The frame-based stereotaxy module has been licensed and certified for use in a commercial image guidance system. Conclusions: It is feasible to encapsulate image manipulation and surgical guidance tasks in individual, reusable software modules. These modules allow for faster development of new applications. The strict application of object oriented software design methods allows individual components of such a system to make the transition from the research environment to a commercial one.

  6. 27 CFR 447.31 - Registration requirement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Registration requirement. 447.31 Section 447.31 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION IMPORTATION OF ARMS, AMMUNITION AND...

  7. 27 CFR 447.31 - Registration requirement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Registration requirement. 447.31 Section 447.31 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION IMPORTATION OF ARMS, AMMUNITION AND...

  8. 27 CFR 447.31 - Registration requirement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Registration requirement. 447.31 Section 447.31 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION IMPORTATION OF ARMS, AMMUNITION AND...

  9. 27 CFR 447.31 - Registration requirement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Registration requirement. 447.31 Section 447.31 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION IMPORTATION OF ARMS, AMMUNITION AND...

  10. 27 CFR 447.31 - Registration requirement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Registration requirement. 447.31 Section 447.31 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION IMPORTATION OF ARMS, AMMUNITION AND...

  11. 14 CFR 103.7 - Certification and registration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Certification and registration. 103.7 Section 103.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... required to meet any aeronautical knowledge, age, or experience requirements to operate those vehicles or...

  12. 14 CFR 103.7 - Certification and registration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Certification and registration. 103.7 Section 103.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... required to meet any aeronautical knowledge, age, or experience requirements to operate those vehicles or...

  13. 75 FR 44655 - Registration of Mortgage Loan Originators

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... requires an employee of a bank, savings association, credit union or Farm Credit System (FCS) institution... (collectively, Agency-regulated institutions) who acts as a residential mortgage loan originator to register... this registration. The final rule further provides that Agency- regulated institutions must: require...

  14. 21 CFR 118.11 - Registration requirements for shell egg producers covered by the requirements of this part.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of this form by writing to the U.S. Food and Drug Administration, 5600 Fishers Lane (HFS-681...) alphabet. (e) Each registrant must submit the following information through one of the methods described in...

  15. 21 CFR 118.11 - Registration requirements for shell egg producers covered by the requirements of this part.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of this form by writing to the U.S. Food and Drug Administration, 5600 Fishers Lane (HFS-681...) alphabet. (e) Each registrant must submit the following information through one of the methods described in...

  16. 21 CFR 118.11 - Registration requirements for shell egg producers covered by the requirements of this part.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of this form by writing to the U.S. Food and Drug Administration, 5600 Fishers Lane (HFS-681...) alphabet. (e) Each registrant must submit the following information through one of the methods described in...

  17. Non-rigid CT/CBCT to CBCT registration for online external beam radiotherapy guidance

    NASA Astrophysics Data System (ADS)

    Zachiu, Cornel; de Senneville, Baudouin Denis; Tijssen, Rob H. N.; Kotte, Alexis N. T. J.; Houweling, Antonetta C.; Kerkmeijer, Linda G. W.; Lagendijk, Jan J. W.; Moonen, Chrit T. W.; Ries, Mario

    2018-01-01

    Image-guided external beam radiotherapy (EBRT) allows radiation dose deposition with a high degree of accuracy and precision. Guidance is usually achieved by estimating the displacements, via image registration, between cone beam computed tomography (CBCT) and computed tomography (CT) images acquired at different stages of the therapy. The resulting displacements are then used to reposition the patient such that the location of the tumor at the time of treatment matches its position during planning. Moreover, ongoing research aims to use CBCT-CT image registration for online plan adaptation. However, CBCT images are usually acquired using a small number of x-ray projections and/or low beam intensities. This often leads to the images being subject to low contrast, low signal-to-noise ratio and artifacts, which ends-up hampering the image registration process. Previous studies addressed this by integrating additional image processing steps into the registration procedure. However, these steps are usually designed for particular image acquisition schemes, therefore limiting their use on a case-by-case basis. In the current study we address CT to CBCT and CBCT to CBCT registration by the means of the recently proposed EVolution registration algorithm. Contrary to previous approaches, EVolution does not require the integration of additional image processing steps in the registration scheme. Moreover, the algorithm requires a low number of input parameters, is easily parallelizable and provides an elastic deformation on a point-by-point basis. Results have shown that relative to a pure CT-based registration, the intrinsic artifacts present in typical CBCT images only have a sub-millimeter impact on the accuracy and precision of the estimated deformation. In addition, the algorithm has low computational requirements, which are compatible with online image-based guidance of EBRT treatments.

  18. Robust multi-site MR data processing: iterative optimization of bias correction, tissue classification, and registration.

    PubMed

    Young Kim, Eun; Johnson, Hans J

    2013-01-01

    A robust multi-modal tool, for automated registration, bias correction, and tissue classification, has been implemented for large-scale heterogeneous multi-site longitudinal MR data analysis. This work focused on improving the an iterative optimization framework between bias-correction, registration, and tissue classification inspired from previous work. The primary contributions are robustness improvements from incorporation of following four elements: (1) utilize multi-modal and repeated scans, (2) incorporate high-deformable registration, (3) use extended set of tissue definitions, and (4) use of multi-modal aware intensity-context priors. The benefits of these enhancements were investigated by a series of experiments with both simulated brain data set (BrainWeb) and by applying to highly-heterogeneous data from a 32 site imaging study with quality assessments through the expert visual inspection. The implementation of this tool is tailored for, but not limited to, large-scale data processing with great data variation with a flexible interface. In this paper, we describe enhancements to a joint registration, bias correction, and the tissue classification, that improve the generalizability and robustness for processing multi-modal longitudinal MR scans collected at multi-sites. The tool was evaluated by using both simulated and simulated and human subject MRI images. With these enhancements, the results showed improved robustness for large-scale heterogeneous MRI processing.

  19. An automated dose tracking system for adaptive radiation therapy.

    PubMed

    Liu, Chang; Kim, Jinkoo; Kumarasiri, Akila; Mayyas, Essa; Brown, Stephen L; Wen, Ning; Siddiqui, Farzan; Chetty, Indrin J

    2018-02-01

    The implementation of adaptive radiation therapy (ART) into routine clinical practice is technically challenging and requires significant resources to perform and validate each process step. The objective of this report is to identify the key components of ART, to illustrate how a specific automated procedure improves efficiency, and to facilitate the routine clinical application of ART. Data was used from patient images, exported from a clinical database and converted to an intermediate format for point-wise dose tracking and accumulation. The process was automated using in-house developed software containing three modularized components: an ART engine, user interactive tools, and integration tools. The ART engine conducts computing tasks using the following modules: data importing, image pre-processing, dose mapping, dose accumulation, and reporting. In addition, custom graphical user interfaces (GUIs) were developed to allow user interaction with select processes such as deformable image registration (DIR). A commercial scripting application programming interface was used to incorporate automated dose calculation for application in routine treatment planning. Each module was considered an independent program, written in C++or C#, running in a distributed Windows environment, scheduled and monitored by integration tools. The automated tracking system was retrospectively evaluated for 20 patients with prostate cancer and 96 patients with head and neck cancer, under institutional review board (IRB) approval. In addition, the system was evaluated prospectively using 4 patients with head and neck cancer. Altogether 780 prostate dose fractions and 2586 head and neck cancer dose fractions went processed, including DIR and dose mapping. On average, daily cumulative dose was computed in 3 h and the manual work was limited to 13 min per case with approximately 10% of cases requiring an additional 10 min for image registration refinement. An efficient and convenient dose tracking system for ART in the clinical setting is presented. The software and automated processes were rigorously evaluated and validated using patient image datasets. Automation of the various procedures has improved efficiency significantly, allowing for the routine clinical application of ART for improving radiation therapy effectiveness. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Deformable image registration with a featurelet algorithm: implementation as a 3D-slicer extension and validation

    NASA Astrophysics Data System (ADS)

    Renner, A.; Furtado, H.; Seppenwoolde, Y.; Birkfellner, W.; Georg, D.

    2016-03-01

    A radiotherapy (RT) treatment can last for several weeks. In that time organ motion and shape changes introduce uncertainty in dose application. Monitoring and quantifying the change can yield a more precise irradiation margin definition and thereby reduce dose delivery to healthy tissue and adjust tumor targeting. Deformable image registration (DIR) has the potential to fulfill this task by calculating a deformation field (DF) between a planning CT and a repeated CT of the altered anatomy. Application of the DF on the original contours yields new contours that can be used for an adapted treatment plan. DIR is a challenging method and therefore needs careful user interaction. Without a proper graphical user interface (GUI) a misregistration cannot be easily detected by visual inspection and the results cannot be fine-tuned by changing registration parameters. To provide a DIR algorithm with such a GUI available for everyone, we created the extension Featurelet-Registration for the open source software platform 3D Slicer. The registration logic is an upgrade of an in-house-developed DIR method, which is a featurelet-based piecewise rigid registration. The so called "featurelets" are equally sized rectangular subvolumes of the moving image which are rigidly registered to rectangular search regions on the fixed image. The output is a deformed image and a deformation field. Both can be visualized directly in 3D Slicer facilitating the interpretation and quantification of the results. For validation of the registration accuracy two deformable phantoms were used. The performance was benchmarked against a demons algorithm with comparable results.

  1. Serial Scanning and Registration of High Resolution Quantitative Computed Tomography Volume Scans for the Determination of Local Bone Density Changes

    NASA Technical Reports Server (NTRS)

    Whalen, Robert T.; Napel, Sandy; Yan, Chye H.

    1996-01-01

    Progress in development of the methods required to study bone remodeling as a function of time is reported. The following topics are presented: 'A New Methodology for Registration Accuracy Evaluation', 'Registration of Serial Skeletal Images for Accurately Measuring Changes in Bone Density', and 'Precise and Accurate Gold Standard for Multimodality and Serial Registration Method Evaluations.'

  2. 21 CFR 1271.25 - What information is required for establishment registration and HCT/P listing?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... registration and HCT/P listing? 1271.25 Section 1271.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... HCT/P listing? (a) Your establishment registration Form FDA 3356 must include: (1) The legal name(s... registration and HCT/P listing form is true and accurate, to the best of his or her knowledge. (b) Your HCT/P...

  3. 21 CFR 1271.25 - What information is required for establishment registration and HCT/P listing?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... registration and HCT/P listing? 1271.25 Section 1271.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... HCT/P listing? (a) Your establishment registration Form FDA 3356 must include: (1) The legal name(s... registration and HCT/P listing form is true and accurate, to the best of his or her knowledge. (b) Your HCT/P...

  4. 28 CFR 3.3 - Registration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Registration. 3.3 Section 3.3 Judicial Administration DEPARTMENT OF JUSTICE GAMBLING DEVICES § 3.3 Registration. Persons required to register pursuant to section 3 of the Act shall register with the Assistant Attorney General, Criminal Division...

  5. 28 CFR 3.3 - Registration.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Registration. 3.3 Section 3.3 Judicial Administration DEPARTMENT OF JUSTICE GAMBLING DEVICES § 3.3 Registration. Persons required to register pursuant to section 3 of the Act shall register with the Assistant Attorney General, Criminal Division...

  6. 28 CFR 3.3 - Registration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Registration. 3.3 Section 3.3 Judicial Administration DEPARTMENT OF JUSTICE GAMBLING DEVICES § 3.3 Registration. Persons required to register pursuant to section 3 of the Act shall register with the Assistant Attorney General, Criminal Division...

  7. 28 CFR 3.3 - Registration.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Registration. 3.3 Section 3.3 Judicial Administration DEPARTMENT OF JUSTICE GAMBLING DEVICES § 3.3 Registration. Persons required to register pursuant to section 3 of the Act shall register with the Assistant Attorney General, Criminal Division...

  8. 28 CFR 3.3 - Registration.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Registration. 3.3 Section 3.3 Judicial Administration DEPARTMENT OF JUSTICE GAMBLING DEVICES § 3.3 Registration. Persons required to register pursuant to section 3 of the Act shall register with the Assistant Attorney General, Criminal Division...

  9. 14 CFR 431.85 - Registration of space objects.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Registration of space objects. 431.85 Section 431.85 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.85 Registration of space...

  10. 14 CFR 431.85 - Registration of space objects.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Registration of space objects. 431.85 Section 431.85 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.85 Registration of space...

  11. 14 CFR 431.85 - Registration of space objects.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Registration of space objects. 431.85 Section 431.85 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.85 Registration of space...

  12. 14 CFR 431.85 - Registration of space objects.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Registration of space objects. 431.85 Section 431.85 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.85 Registration of space...

  13. 14 CFR 431.85 - Registration of space objects.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Registration of space objects. 431.85 Section 431.85 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... Requirements-Reusable Launch Vehicle Mission License Terms and Conditions § 431.85 Registration of space...

  14. 76 FR 5106 - Deposit Requirements for Registration of Automated Databases That Predominantly Consist of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... Registration of Automated Databases That Predominantly Consist of Photographs AGENCY: Copyright Office, Library... regarding electronic registration of automated databases that consist predominantly of photographs and group... applications for automated databases that consist predominantly of photographs. The proposed amendments would...

  15. 76 FR 6185 - Registration of Mortgage Loan Originators

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... UNION ADMINISTRATION Registration of Mortgage Loan Originators AGENCY: Office of the Comptroller of the..., Agency-regulated institutions) who act as a residential mortgage loan originator to register with the... registration system for mortgage loan originators. Specifically, the Act requires: (1) All States to provide...

  16. 7 CFR 1230.627 - Registration form and ballot.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... registration form includes name, address, and telephone number. Form LS-72-2 also contains the certification... required on this combined registration and voting form includes name, address, and telephone number. Form... includes name, address, and telephone number. Form LS-76 also contains the certification statement...

  17. 40 CFR 161.150 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements § 161.150 General. (a) Applicability. This subpart describes the product chemistry data that are required to support the registration... agreeing to abide by the standard limits in § 161.175). (4) Physical and chemical characteristics. (i) Data...

  18. 17 CFR 230.484 - Undertaking required in certain registration statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Undertaking required in certain registration statements. 230.484 Section 230.484 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 Investment Companies; Business...

  19. 17 CFR 210.11-01 - Presentation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... registrant's most recent annual consolidated financial statements filed at or prior to the date of... AND CONTENT OF AND REQUIREMENTS FOR FINANCIAL STATEMENTS, SECURITIES ACT OF 1933, SECURITIES EXCHANGE... fully reflected in the financial statements of the registrant included in the filing; (5) During the...

  20. 76 FR 57060 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-D-0588] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products; Draft Guidance for Industry on Pharmacovigilance of Veterinary Medicinal Products: Electronic...

  1. Web-based interactive 2D/3D medical image processing and visualization software.

    PubMed

    Mahmoudi, Seyyed Ehsan; Akhondi-Asl, Alireza; Rahmani, Roohollah; Faghih-Roohi, Shahrooz; Taimouri, Vahid; Sabouri, Ahmad; Soltanian-Zadeh, Hamid

    2010-05-01

    There are many medical image processing software tools available for research and diagnosis purposes. However, most of these tools are available only as local applications. This limits the accessibility of the software to a specific machine, and thus the data and processing power of that application are not available to other workstations. Further, there are operating system and processing power limitations which prevent such applications from running on every type of workstation. By developing web-based tools, it is possible for users to access the medical image processing functionalities wherever the internet is available. In this paper, we introduce a pure web-based, interactive, extendable, 2D and 3D medical image processing and visualization application that requires no client installation. Our software uses a four-layered design consisting of an algorithm layer, web-user-interface layer, server communication layer, and wrapper layer. To compete with extendibility of the current local medical image processing software, each layer is highly independent of other layers. A wide range of medical image preprocessing, registration, and segmentation methods are implemented using open source libraries. Desktop-like user interaction is provided by using AJAX technology in the web-user-interface. For the visualization functionality of the software, the VRML standard is used to provide 3D features over the web. Integration of these technologies has allowed implementation of our purely web-based software with high functionality without requiring powerful computational resources in the client side. The user-interface is designed such that the users can select appropriate parameters for practical research and clinical studies. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

  2. Improving transparency and reproducibility through registration: The status of intervention trials published in clinical psychology journals.

    PubMed

    Cybulski, Lukasz; Mayo-Wilson, Evan; Grant, Sean

    2016-09-01

    Prospective registration increases the validity of randomized controlled trials (RCTs). In the United States, registration is a legal requirement for drugs and devices regulated by the Food and Drug Administration (FDA), and many biomedical journals refuse to publish trials that are not registered. Trials in clinical psychology have not been subject to these requirements; it is unknown to what extent they are registered. We searched the 25 highest-impact clinical psychology journals that published at least 1 RCT of a health-related psychological intervention in 2013. For included trials, we evaluated their registration status (prospective, retrospective, not registered) and the completeness of their outcome definitions. We identified 163 articles that reported 165 RCTs; 73 (44%) RCTs were registered, of which only 25 (15%) were registered prospectively. Of registered RCTs, only 42 (58%) indicated their registration status in the publication. Only 2 (1% of all trials) were registered prospectively and defined their primary outcomes completely. For the primary outcome(s), 72 (99%) of all registrations defined the domain, 67 (92%) the time frame, and 48 (66%) the specific measurements. Only 19 (26%) and 5 (7%) defined the specific metric and method of aggregation, respectively, for all primary outcomes. Very few reports of RCTs published in clinical psychology journals were registered prospectively and completely. Clinical psychology journals could improve transparency and reproducibility, as well as reduce bias, by requiring complete prospective trial registration for publication and by including trial registration numbers in all reports of RCTs. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  3. 47 CFR 17.4 - Antenna structure registration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Antenna structure registration. 17.4 Section 17... ANTENNA STRUCTURES General Information § 17.4 Antenna structure registration. (a) Effective July 1, 1996, the owner of any proposed or existing antenna structure that requires notice of proposed construction...

  4. 47 CFR 17.4 - Antenna structure registration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Antenna structure registration. 17.4 Section 17... ANTENNA STRUCTURES General Information § 17.4 Antenna structure registration. (a) Effective July 1, 1996, the owner of any proposed or existing antenna structure that requires notice of proposed construction...

  5. 16 CFR 1130.6 - Requirements for format of registration forms.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... manufacturer's name and mailing address where registration information is to be collected. (c) Font size and typeface. The registration form shall use bold black typeface. The size of the type shall be at least 12... information shall be in capital and lower case type. ...

  6. 14 CFR 47.63 - Application.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...'s Aircraft Registration Certificate Application, AC Form 8050-5; and (b) The fee required by § 47.17... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Application. 47.63 Section 47.63... REGISTRATION Dealers' Aircraft Registration Certificate § 47.63 Application. A manufacturer or dealer that...

  7. 14 CFR 47.63 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Application for Dealers' Aircraft Registration Certificates, AC Form 8050-5; and (b) The fee required by § 47... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Application. 47.63 Section 47.63... REGISTRATION Dealers' Aircraft Registration Certificate § 47.63 Application. A manufacturer or dealer that...

  8. 14 CFR 47.63 - Application.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...'s Aircraft Registration Certificate Application, AC Form 8050-5; and (b) The fee required by § 47.17... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Application. 47.63 Section 47.63... REGISTRATION Dealers' Aircraft Registration Certificate § 47.63 Application. A manufacturer or dealer that...

  9. 14 CFR 47.1 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGISTRATION General § 47.1 Applicability. This part prescribes the requirements for registering aircraft under... Aircraft Registration, AC Form8050-3. Subpart C applies to each applicant for, and holder of, a Dealer's Aircraft Registration Certificate, AC Form 8050-6. [Amdt. 47-29, 75 FR 41979, July 20, 2010] ...

  10. 14 CFR 47.1 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGISTRATION General § 47.1 Applicability. This part prescribes the requirements for registering aircraft under... Aircraft Registration, AC Form8050-3. Subpart C applies to each applicant for, and holder of, a Dealer's Aircraft Registration Certificate, AC Form 8050-6. [Amdt. 47-29, 75 FR 41979, July 20, 2010] ...

  11. 14 CFR 47.1 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGISTRATION General § 47.1 Applicability. This part prescribes the requirements for registering aircraft under... Aircraft Registration, AC Form8050-3. Subpart C applies to each applicant for, and holder of, a Dealer's Aircraft Registration Certificate, AC Form 8050-6. [Amdt. 47-29, 75 FR 41979, July 20, 2010] ...

  12. 14 CFR 47.1 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGISTRATION General § 47.1 Applicability. This part prescribes the requirements for registering aircraft under... Aircraft Registration, AC Form8050-3. Subpart C applies to each applicant for, and holder of, a Dealer's Aircraft Registration Certificate, AC Form 8050-6. [Amdt. 47-29, 75 FR 41979, July 20, 2010] ...

  13. Does Wait-List Size at Registration Influence Time to Surgery? Analysis of a Population-Based Cardiac Surgery Registry

    PubMed Central

    Sobolev, Boris; Levy, Adrian; Hayden, Robert; Kuramoto, Lisa

    2006-01-01

    Objective To determine whether the probability of undergoing coronary bypass surgery within a certain time was related to the number of patients on the wait list at registration for the operation in a publicly funded health system. Methods A prospective cohort study comparing waiting times among patients registered on wait lists at the hospitals delivering adult cardiac surgery. For each calendar week, the list size, the number of new registrations, and the number of direct admissions immediately after angiography characterized the demand for surgery. Results The length of delay in undergoing treatment was associated with list size at registration, with shorter times for shorter lists (log-rank test 1,198.3, p<.0001). When the list size at registration required clearance time over 1 week patients had 42 percent lower odds of undergoing surgery compared with lists with clearance time less than 1 week (odds ratio [OR] 0.58 percent, 95 percent, confidence interval [CI] 0.53–0.63), after adjustment for age, sex, comorbidity, period, and hospital. The weekly number of new registrations exceeding weekly service capacity had an independent effect toward longer service delays when the list size at registration required clearance time less than 1 week (OR 0.56 percent, 95 percent CI 0.45–0.71), but not for longer lists. Every time the operation was performed for a patient requiring surgery without registration on wait lists, the odds of surgery for listed patients were reduced by 6 percent (OR 0.94, CI 0.93–0.95). Conclusion For wait-listed patients, time to surgery depends on the list size at registration, the number of new registrations, as well as on the weekly number of patients who move immediately from angiography to coronary bypass surgery without being registered on a wait list. Hospital managers may use these findings to improve resource planning and to reduce uncertainty when providing advice on expected treatment delays. PMID:16430599

  14. Simulation Models Evaluation of Pest Resistance Development to Refuge in the Bag Concepts Related to Pioneer Submission

    EPA Science Inventory

    The USEPA, under its administration of the Federal Insecticide Fungicide and Rodenticide Act (FIFRA), requires the registration of all pesticides and pesticidal materials. The GM crops containing pesticidal traits are subject to FIFRA registration requirements. Concerns relating ...

  15. 42 CFR 493.57 - Requirements for a registration certificate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Requirements for a registration certificate. 493.57 Section 493.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN..., name, location, director, or supervisor (laboratories performing high complexity testing only); (3...

  16. 32 CFR 634.6 - Requirements for driving privileges.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 634.6 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW... in any state or host country. (2) Comply with laws and regulations governing motor vehicle operations... Vehicle Registration System (VRS). Vehicle registration is required on all Air Force and DLA installations...

  17. 32 CFR 634.6 - Requirements for driving privileges.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 634.6 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW... in any state or host country. (2) Comply with laws and regulations governing motor vehicle operations... Vehicle Registration System (VRS). Vehicle registration is required on all Air Force and DLA installations...

  18. 32 CFR 634.6 - Requirements for driving privileges.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 634.6 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW... in any state or host country. (2) Comply with laws and regulations governing motor vehicle operations... Vehicle Registration System (VRS). Vehicle registration is required on all Air Force and DLA installations...

  19. 32 CFR 634.6 - Requirements for driving privileges.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 634.6 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW... in any state or host country. (2) Comply with laws and regulations governing motor vehicle operations... Vehicle Registration System (VRS). Vehicle registration is required on all Air Force and DLA installations...

  20. 77 FR 40268 - Deposit Requirements for Registration of Automated Databases That Predominantly Consist of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... Registration of Automated Databases That Predominantly Consist of Photographs AGENCY: Copyright Office, Library... the deposit requirements for applications for automated databases that consist predominantly of... authorship, the deposits for such databases include the image of each photograph in which copyright is...

  1. 77 FR 20406 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-D-0288] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... been developed for veterinary use by the International Cooperation on Harmonisation of Technical...

  2. 48 CFR 18.102 - Central contractor registration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Central contractor... Central contractor registration. Contractors are not required to be registered in the Central Contractor.... (See 4.1102). However, contractors are required to register with CCR in order to gain access to the...

  3. 77 FR 9522 - Requirements for Consumer Registration of Durable Infant or Toddler Products

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... CONSUMER PRODUCT SAFETY COMMISSION 16 CFR Part 1130 Requirements for Consumer Registration of Durable Infant or Toddler Products AGENCY: Consumer Product Safety Commission. ACTION: Final rule. SUMMARY: In accordance with the Consumer Product Safety Improvement Act of 2008 (``CPSIA''), the Consumer...

  4. 14 CFR 205.3 - Basic requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... classes of aircraft, or the specific aircraft by FAA or foreign government registration number, with... insurance that list aircraft by government registration number, the policy or self-insurance plan shall... REGULATIONS AIRCRAFT ACCIDENT LIABILITY INSURANCE § 205.3 Basic requirements. (a) A U.S. or foreign direct air...

  5. 14 CFR 205.3 - Basic requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... classes of aircraft, or the specific aircraft by FAA or foreign government registration number, with... insurance that list aircraft by government registration number, the policy or self-insurance plan shall... REGULATIONS AIRCRAFT ACCIDENT LIABILITY INSURANCE § 205.3 Basic requirements. (a) A U.S. or foreign direct air...

  6. 14 CFR 205.3 - Basic requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... classes of aircraft, or the specific aircraft by FAA or foreign government registration number, with... insurance that list aircraft by government registration number, the policy or self-insurance plan shall... REGULATIONS AIRCRAFT ACCIDENT LIABILITY INSURANCE § 205.3 Basic requirements. (a) A U.S. or foreign direct air...

  7. 14 CFR 205.3 - Basic requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... classes of aircraft, or the specific aircraft by FAA or foreign government registration number, with... insurance that list aircraft by government registration number, the policy or self-insurance plan shall... REGULATIONS AIRCRAFT ACCIDENT LIABILITY INSURANCE § 205.3 Basic requirements. (a) A U.S. or foreign direct air...

  8. 14 CFR 205.3 - Basic requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... classes of aircraft, or the specific aircraft by FAA or foreign government registration number, with... insurance that list aircraft by government registration number, the policy or self-insurance plan shall... REGULATIONS AIRCRAFT ACCIDENT LIABILITY INSURANCE § 205.3 Basic requirements. (a) A U.S. or foreign direct air...

  9. 31 CFR 351.43 - Are taxpayer identification numbers (TINs) required for the registration of a definitive Series...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (TINs) required for the registration of a definitive Series EE savings bond? 351.43 Section 351.43 Money... Definitive Series EE Savings Bonds § 351.43 Are taxpayer identification numbers (TINs) required for the... must include the TIN of the owner or first-named coowner. The TIN of the second-named coowner or...

  10. 31 CFR 351.43 - Are taxpayer identification numbers (TINs) required for the registration of a definitive Series...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (TINs) required for the registration of a definitive Series EE savings bond? 351.43 Section 351.43 Money... Definitive Series EE Savings Bonds § 351.43 Are taxpayer identification numbers (TINs) required for the... must include the TIN of the owner or first-named coowner. The TIN of the second-named coowner or...

  11. 31 CFR 351.43 - Are taxpayer identification numbers (TINs) required for the registration of a definitive Series...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (TINs) required for the registration of a definitive Series EE savings bond? 351.43 Section 351.43 Money... Definitive Series EE Savings Bonds § 351.43 Are taxpayer identification numbers (TINs) required for the... must include the TIN of the owner or first-named coowner. The TIN of the second-named coowner or...

  12. 31 CFR 351.43 - Are taxpayer identification numbers (TINs) required for the registration of a definitive Series...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (TINs) required for the registration of a definitive Series EE savings bond? 351.43 Section 351.43 Money... Definitive Series EE Savings Bonds § 351.43 Are taxpayer identification numbers (TINs) required for the... must include the TIN of the owner or first-named coowner. The TIN of the second-named coowner or...

  13. 31 CFR 351.43 - Are taxpayer identification numbers (TINs) required for the registration of a definitive Series...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (TINs) required for the registration of a definitive Series EE savings bond? 351.43 Section 351.43 Money... Definitive Series EE Savings Bonds § 351.43 Are taxpayer identification numbers (TINs) required for the... must include the TIN of the owner or first-named coowner. The TIN of the second-named coowner or...

  14. Analyses of Trends in High School Students' Math-Science Course Credit Attainment and Registrations in Texas

    ERIC Educational Resources Information Center

    Zeng, Liang; Poelzer, G. Herold

    2016-01-01

    This study describes the trends in course credit attainment (CCA) of high school students in required and non-required science and math courses and trends in registration in non-required science and math courses in Texas between 1997 and 2009. Using Texas Public Education Information Management System data between 1997 and 2009, it presents…

  15. Critical issues related to registration of space objects and transparency of space activities

    NASA Astrophysics Data System (ADS)

    Jakhu, Ram S.; Jasani, Bhupendra; McDowell, Jonathan C.

    2018-02-01

    The main purpose of the 1975 Registration Convention is to achieve transparency in space activities and this objective is motivated by the belief that a mandatory registration system would assist in the identification of space objects launched into outer space. This would also consequently contribute to the application and development of international law governing the exploration and use of outer space. States Parties to the Convention furnish the required information to the United Nations' Register of Space Objects. However, the furnished information is often so general that it may not be as helpful in creating transparency as had been hoped by the drafters of the Convention. While registration of civil satellites has been furnished with some general details, till today, none of the Parties have described the objects as having military functions despite the fact that a large number of such objects do perform military functions as well. In some cases, the best they have done is to indicate that the space objects are for their defense establishments. Moreover, the number of registrations of space objects is declining. This paper addresses the challenges posed by the non-registration of space objects. Particularly, the paper provides some data about the registration and non-registration of satellites and the States that have and have not complied with their legal obligations. It also analyses the specific requirements of the Convention, the reasons for non-registration, new challenges posed by the registration of small satellites and the on-orbit transfer of satellites. Finally, the paper provides some recommendations on how to enhance the registration of space objects, on the monitoring of the implementation of the Registration Convention and consequently how to achieve maximum transparency in space activities.

  16. 28 CFR 811.1 - Purpose and scope; relation to District of Columbia regulations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and requirements relating to registration, verification, and changes in information for sex offenders... SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.1 Purpose and scope; relation to District of Columbia regulations. (a) In accordance with its sex offender registration functions...

  17. 28 CFR 811.1 - Purpose and scope; relation to District of Columbia regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and requirements relating to registration, verification, and changes in information for sex offenders... SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.1 Purpose and scope; relation to District of Columbia regulations. (a) In accordance with its sex offender registration functions...

  18. 28 CFR 811.1 - Purpose and scope; relation to District of Columbia regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and requirements relating to registration, verification, and changes in information for sex offenders... SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.1 Purpose and scope; relation to District of Columbia regulations. (a) In accordance with its sex offender registration functions...

  19. 28 CFR 811.1 - Purpose and scope; relation to District of Columbia regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and requirements relating to registration, verification, and changes in information for sex offenders... SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.1 Purpose and scope; relation to District of Columbia regulations. (a) In accordance with its sex offender registration functions...

  20. 28 CFR 811.1 - Purpose and scope; relation to District of Columbia regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and requirements relating to registration, verification, and changes in information for sex offenders... SUPERVISION AGENCY FOR THE DISTRICT OF COLUMBIA SEX OFFENDER REGISTRATION § 811.1 Purpose and scope; relation to District of Columbia regulations. (a) In accordance with its sex offender registration functions...

  1. 78 FR 76187 - 30-Day Notice of Proposed Information Collection: Exchange Programs Alumni Web Site Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ...: Exchange Programs Alumni Web Site Registration ACTION: Notice of request for public comment and submission... Information Collection: Exchange Programs Alumni Web site Registration. OMB Control Number: 1405-0192. Type of... proposed collection: The International Exchange Alumni Web site requires information to process users...

  2. 31 CFR 1022.380 - Registration of money services businesses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Registration of money services businesses. 1022.380 Section 1022.380 Money and Finance: Treasury Regulations Relating to Money and Finance... BUSINESSES Reports Required To Be Made By Money Services Businesses § 1022.380 Registration of money services...

  3. 31 CFR 1022.380 - Registration of money services businesses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Registration of money services businesses. 1022.380 Section 1022.380 Money and Finance: Treasury Regulations Relating to Money and Finance... BUSINESSES Reports Required To Be Made By Money Services Businesses § 1022.380 Registration of money services...

  4. 31 CFR 1022.380 - Registration of money services businesses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Registration of money services businesses. 1022.380 Section 1022.380 Money and Finance: Treasury Regulations Relating to Money and Finance... BUSINESSES Reports Required To Be Made By Money Services Businesses § 1022.380 Registration of money services...

  5. 31 CFR 1022.380 - Registration of money services businesses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Registration of money services businesses. 1022.380 Section 1022.380 Money and Finance: Treasury Regulations Relating to Money and Finance... BUSINESSES Reports Required To Be Made By Money Services Businesses § 1022.380 Registration of money services...

  6. 17 CFR 156.2 - Registration of broker association.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Regulation 1.41, that, at a minimum, (1) define the term “broker association” to include the relationships..., and (3) require registration of each relationship defined by its rules as a broker association no later than 10 days after establishment of such relationship. Contract market records of registration...

  7. 17 CFR 156.2 - Registration of broker association.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 1.41, that, at a minimum, (1) define the term “broker association” to include the relationships set...) require registration of each relationship defined by its rules as a broker association no later than 10 days after establishment of such relationship. Contract market records of registration shall include...

  8. 17 CFR 156.2 - Registration of broker association.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 1.41, that, at a minimum, (1) define the term “broker association” to include the relationships set...) require registration of each relationship defined by its rules as a broker association no later than 10 days after establishment of such relationship. Contract market records of registration shall include...

  9. 32 CFR 1627.2 - Registration of volunteers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Registration of volunteers. 1627.2 Section 1627... VOLUNTEERS FOR INDUCTION § 1627.2 Registration of volunteers. (a) If a person who is required to be registered but who has failed to register volunteers for induction, he shall be registered. (b) In...

  10. 32 CFR 1627.2 - Registration of volunteers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Registration of volunteers. 1627.2 Section 1627... VOLUNTEERS FOR INDUCTION § 1627.2 Registration of volunteers. (a) If a person who is required to be registered but who has failed to register volunteers for induction, he shall be registered. (b) In...

  11. 32 CFR 1627.2 - Registration of volunteers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Registration of volunteers. 1627.2 Section 1627... VOLUNTEERS FOR INDUCTION § 1627.2 Registration of volunteers. (a) If a person who is required to be registered but who has failed to register volunteers for induction, he shall be registered. (b) In...

  12. 32 CFR 1627.2 - Registration of volunteers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Registration of volunteers. 1627.2 Section 1627... VOLUNTEERS FOR INDUCTION § 1627.2 Registration of volunteers. (a) If a person who is required to be registered but who has failed to register volunteers for induction, he shall be registered. (b) In...

  13. 32 CFR 1627.2 - Registration of volunteers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Registration of volunteers. 1627.2 Section 1627... VOLUNTEERS FOR INDUCTION § 1627.2 Registration of volunteers. (a) If a person who is required to be registered but who has failed to register volunteers for induction, he shall be registered. (b) In...

  14. 17 CFR 270.8b-16 - Amendments to registration statement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.8b-16 Amendments to registration statement. (a) Every registered management investment company which is required to file a semi-annual report... management investment company whose registration statement was filed on Form N-2; provided that the following...

  15. 27 CFR 31.121 - Sale of business.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Sale of business. 31.121... Requiring Registration As A New Business § 31.121 Sale of business. Under this part, registration is... occurs in the proprietorship of a business for which registration has been completed, the successor must...

  16. Advancements in LiDAR-based registration of FIA field plots

    Treesearch

    Demetrios Gatziolis

    2012-01-01

    Meaningful integration of National Forest Inventory field plot information with spectral imagery acquired from satellite or airborne platforms requires precise plot registration. Global positioning system-based plot registration procedures, such as the one employed by the Forest Inventory and Analysis (FIA) Program, yield plot coordinates that, although adequate for...

  17. 21 CFR 1311.125 - Requirements for establishing logical access control-Individual practitioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... least one of the individuals designated under paragraph (a) of this section must verify that the DEA... authentication credential to satisfy the logical access controls. The second individual must be a DEA registrant... practitioner's DEA registration expires, unless the registration has been renewed. (3) The individual...

  18. 40 CFR 162.153 - State registration procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... registered product, the State must require that at the time of sale to users, labeling from the federally... STATE REGISTRATION OF PESTICIDE PRODUCTS Regulations Pertaining to State Registration of Pesticides To... for use. (2) The name of the pesticide product, and, if the application is for an amendment to a...

  19. 14 CFR 47.11 - Evidence of ownership.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... submits an Aircraft Registration Application, AC Form 8050-1 under this part must also submit the required... administrator. The Certificate of Aircraft Registration, AC Form 8050-3 is issued to the applicant as executor... certified copy of the order of the court appointing him guardian. The Certificate of Aircraft Registration...

  20. 14 CFR 47.11 - Evidence of ownership.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... submits an Aircraft Registration Application, AC Form 8050-1 under this part must also submit the required... administrator. The Certificate of Aircraft Registration, AC Form 8050-3 is issued to the applicant as executor... certified copy of the order of the court appointing him guardian. The Certificate of Aircraft Registration...

  1. [Non-rigid medical image registration based on mutual information and thin-plate spline].

    PubMed

    Cao, Guo-gang; Luo, Li-min

    2009-01-01

    To get precise and complete details, the contrast in different images is needed in medical diagnosis and computer assisted treatment. The image registration is the basis of contrast, but the regular rigid registration does not satisfy the clinic requirements. A non-rigid medical image registration method based on mutual information and thin-plate spline was present. Firstly, registering two images globally based on mutual information; secondly, dividing reference image and global-registered image into blocks and registering them; then getting the thin-plate spline transformation according to the shift of blocks' center; finally, applying the transformation to the global-registered image. The results show that the method is more precise than the global rigid registration based on mutual information and it reduces the complexity of getting control points and satisfy the clinic requirements better by getting control points of the thin-plate transformation automatically.

  2. 17 CFR 30.4 - Registration required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... foreign options customers. (d) To solicit or enter into an agreement to direct, or to guide such customer... Section 30.4 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION FOREIGN FUTURES AND FOREIGN OPTIONS TRANSACTIONS § 30.4 Registration required. Except as provided in § 30.5 of this part, it...

  3. 42 CFR 493.45 - Requirements for a registration certificate.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Requirements for a registration certificate. 493.45 Section 493.45 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... certificate is required—(1) Initially for all laboratories performing test procedures of moderate complexity...

  4. 42 CFR 493.45 - Requirements for a registration certificate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Requirements for a registration certificate. 493.45 Section 493.45 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... certificate is required—(1) Initially for all laboratories performing test procedures of moderate complexity...

  5. 17 CFR 230.403 - Requirements as to paper, printing, language and pagination.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., printing, language and pagination. 230.403 Section 230.403 Commodity and Securities Exchanges SECURITIES... § 230.403 Requirements as to paper, printing, language and pagination. (a) Registration statements... submissions must be in the English language, except as otherwise provided by this section. If a registration...

  6. 78 FR 16498 - Proposed Information Collection Request; Comment Request; Registration of Fuels and Fuel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... fuel or additive, and certain technical, marketing, and health-effects information. The development of... Request; Comment Request; Registration of Fuels and Fuel Additives--Requirements for Manufacturers; EPA... Fuels and Fuel Additives--Requirements for Manufacturers'' (EPA ICR No. 0309.14, OMB Control No. 2060...

  7. 17 CFR 156.2 - Registration of broker association.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Contract market rules required. Each contract market must adopt and maintain in effect rules, which have... 1.41, that, at a minimum, (1) define the term “broker association” to include the relationships set...) require registration of each relationship defined by its rules as a broker association no later than 10...

  8. 27 CFR 31.122 - Incorporation of business.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Incorporation of business... Requiring Registration As A New Business § 31.122 Incorporation of business. Where an individual or a firm engaged in business requiring registration under this part forms a corporation to take over and conduct...

  9. 78 FR 12063 - Announcement of Requirements and Registration for healthfinder.gov Mobile App Challenge; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for..., Office of the Assistant Secretary for Health, Office of the Secretary, Department of Health and Human... subsection of the terms and conditions. FOR FURTHER INFORMATION CONTACT: Silje Lier, MPH, Communication...

  10. 76 FR 57044 - Announcement of Requirements and Registration for “Ensuring Safe Transitions From Hospital to Home”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for... Coordinator for Health Information Technology, HHS. ACTION: Notice. SUMMARY: The ``Ensuring Safe Transitions... discharged patients to take charge of their health care during transitions of places of care. Innovative...

  11. 76 FR 60842 - Announcement of Requirements and Registration for “popHealth Tools Development Challenge”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... selections based upon the following criteria: 1. Ability to integrate with popHealth system and build upon... DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for ``popHealth Tools Development Challenge'' AGENCY: Office of the National Coordinator for Health Information...

  12. 76 FR 57045 - Announcement of Requirements and Registration for “Reporting Device Adverse Events Challenge”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for... Coordinator for Health Information Technology, HHS. ACTION: Notice. SUMMARY: Medical devices will play an increasingly large role in the monitoring and collection of patient data with the spread of electronic health...

  13. 76 FR 44588 - Announcement of Requirements and Registration for “Using Public Data for Cancer Prevention and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for ``Using... Challenge'' is a challenge aimed at encouraging multidisciplinary teams of software developers... Human Services. The statutory authority for this challenge competition is Section 105 of the America...

  14. 76 FR 57058 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2010-D-0165] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products; Guidance for Industry on Studies To Evaluate the Metabolism and Residue Kinetics of Veterinary...

  15. 75 FR 7550 - Requirements for Consumer Registration of Durable Infant or Toddler Products; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... a final rule under section 104(d) of the Consumer Product Safety Improvement Act of 2008 (``CPSIA... CONSUMER PRODUCT SAFETY COMMISSION 16 CFR Part 1130 Requirements for Consumer Registration of Durable Infant or Toddler Products; Correction AGENCY: Consumer Product Safety Commission. ACTION: Final...

  16. A post-processing system for automated rectification and registration of spaceborne SAR imagery

    NASA Technical Reports Server (NTRS)

    Curlander, John C.; Kwok, Ronald; Pang, Shirley S.

    1987-01-01

    An automated post-processing system has been developed that interfaces with the raw image output of the operational digital SAR correlator. This system is designed for optimal efficiency by using advanced signal processing hardware and an algorithm that requires no operator interaction, such as the determination of ground control points. The standard output is a geocoded image product (i.e. resampled to a specified map projection). The system is capable of producing multiframe mosaics for large-scale mapping by combining images in both the along-track direction and adjacent cross-track swaths from ascending and descending passes over the same target area. The output products have absolute location uncertainty of less than 50 m and relative distortion (scale factor and skew) of less than 0.1 per cent relative to local variations from the assumed geoid.

  17. Computer registration of radioactive indicator-dilution curves.

    PubMed

    Shepherd, A P; Perry, M A; Alexander, G M; Granger, D N; Riedel, G L; Kvietys, P R; Franke, C P

    1983-12-01

    A system is described for recording indicator-dilution curves produced by gamma radiation-emitting tracers. The system consists of a flow-through cuvette in a well counter, appropriate commercially available gamma radiation-detecting equipment, an Apple II computer, and a two-channel pulse-counting interface of our own design. With the counting interface and the software described here, an investigator can simultaneously record two indicator-dilution curves produced by gamma emitters. Instead of having to wait hours or days for results, the investigator can watch the data being recorded and display the results in graphic form almost immediately after each injection.

  18. DLSanalysis.org: a web interface for analysis of dynamic light scattering data.

    PubMed

    Hansen, Steen

    2018-03-01

    A web interface ( www.DLSanalysis.org ) for indirect Laplace transformation of dynamic light scattering data is presented. When experimental data are uploaded to the server they are processed in a few seconds, and the result is displayed on the screen in the form of a size distribution together with the experimental data and the fit to the data. No other user input than the experimental data is necessary, but various options for the analysis may be selected. No local installation of software or registration is necessary. The result of the analysis can be downloaded.

  19. Hematology journals do not sufficiently adhere to reporting guidelines: a systematic review.

    PubMed

    Wayant, C; Smith, C; Sims, M; Vassar, M

    2017-04-01

    Essentials Reporting guidelines and trial/review registration aim to limit bias in research. We systematically reviewed hematology journals to examine the use of these policies. Forty-eight percent of journals made no use of these policies. Improving the use of reporting guidelines will improve research for all stakeholders. Background Reporting guidelines and trial/review registration policies have been instituted in order to minimize bias and improve research practices. Objective The objective of this study was to investigate the policies of hematology journals concerning reporting guideline adoption and trial/review registration. Methods We performed a web-based data abstraction from the Instructions for Authors of 67 hematology journals catalogued in the Expanded Science Citation Index of the 2014 Journal Citation Reports to identify whether each journal required, recommended or made no mention of the following reporting guidelines: EQUATOR, ICMJE, CONSORT, MOOSE, QUOROM, PRISMA, STARD, STROBE, ARRIVE and CARE. We also extracted whether journals required or recommended trial or systematic review registration. We e-mailed editors three times to determine which types of studies their journal accepts. Results Forty-eight per cent (32/67) of hematology journals do not adhere to any reporting guidelines. For responding journals, the QUOROM statement, MOOSE, CARE and PROSPERO were the least often mentioned, whereas the ICMJE guidelines, CONSORT statement and general trial registration were most often mentioned. Discussion Reporting guidelines are infrequently required or recommended by hematology journals. Furthermore, few require clinical trial or systematic review database registration. A higher rate of adherence to reporting guidelines can prevent bias from entering the literature. Participation from all stakeholders, including authors and journal editors, to improve reporting guideline and policy practices is required. © 2017 International Society on Thrombosis and Haemostasis.

  20. Challenges for the registration of vaccines in emerging countries: Differences in dossier requirements, application and evaluation processes.

    PubMed

    Dellepiane, Nora; Pagliusi, Sonia

    2018-06-07

    The divergence of regulatory requirements and processes in developing and emerging countries contributes to hamper vaccines' registration, and therefore delay access to high-quality, safe and efficacious vaccines for their respective populations. This report focuses on providing insights on the heterogeneity of registration requirements in terms of numbering structure and overall content of dossiers for marketing authorisation applications for vaccines in different areas of the world. While it also illustrates the divergence of regulatory processes in general, as well as the need to avoid redundant reviews, it does not claim to provide a comprehensive view of all processes nor existing facilitating mechanisms, nor is it intended to touch upon the differences in assessments made by different regulatory authorities. This report describes the work analysed by regulatory experts from vaccine manufacturing companies during a meeting held in Geneva in May 2017, in identifying and quantifying differences in the requirements for vaccine registration in three aspects for comparison: the dossier numbering structure and contents, the application forms, and the evaluation procedures, in different countries and regions. The Module 1 of the Common Technical Document (CTD) of 10 countries were compared. Modules 2-5 of the CTDs of two regions and three countries were compared to the CTD of the US FDA. The application forms of eight countries were compared and the registration procedures of 134 importing countries were compared as well. The analysis indicates a high degree of divergence in numbering structure and content requirements. Possible interventions that would lead to significant improvements in registration efficiency include alignment in CTD numbering structure, a standardised model-application form, and better convergence of evaluation procedures. Copyright © 2018.

  1. Lesson 6: Registration

    EPA Pesticide Factsheets

    Lesson 6 provides CROMERR checklist items grouped under the Registration Process, where users establish their accounts in the system. This process typically requires users to provide information about them.

  2. 31 CFR 359.28 - Are taxpayer identification numbers (TINs) required for the registration of definitive Series I...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (TINs) required for the registration of definitive Series I savings bonds? 359.28 Section 359.28 Money... Definitive Series I Savings Bonds § 359.28 Are taxpayer identification numbers (TINs) required for the... include the TIN of the owner or first-named coowner. If the bond was purchased as a gift or award and the...

  3. 31 CFR 359.28 - Are taxpayer identification numbers (TINs) required for the registration of definitive Series I...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (TINs) required for the registration of definitive Series I savings bonds? 359.28 Section 359.28 Money... Definitive Series I Savings Bonds § 359.28 Are taxpayer identification numbers (TINs) required for the... include the TIN of the owner or first-named coowner. If the bond is being purchased as a gift or award and...

  4. 31 CFR 359.28 - Are taxpayer identification numbers (TINs) required for the registration of definitive Series I...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (TINs) required for the registration of definitive Series I savings bonds? 359.28 Section 359.28 Money... Definitive Series I Savings Bonds § 359.28 Are taxpayer identification numbers (TINs) required for the... include the TIN of the owner or first-named coowner. If the bond was purchased as a gift or award and the...

  5. 31 CFR 359.28 - Are taxpayer identification numbers (TINs) required for the registration of definitive Series I...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (TINs) required for the registration of definitive Series I savings bonds? 359.28 Section 359.28 Money... Definitive Series I Savings Bonds § 359.28 Are taxpayer identification numbers (TINs) required for the... include the TIN of the owner or first-named coowner. If the bond is being purchased as a gift or award and...

  6. 31 CFR 359.28 - Are taxpayer identification numbers (TINs) required for the registration of definitive Series I...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (TINs) required for the registration of definitive Series I savings bonds? 359.28 Section 359.28 Money... Definitive Series I Savings Bonds § 359.28 Are taxpayer identification numbers (TINs) required for the... include the TIN of the owner or first-named coowner. If the bond was purchased as a gift or award and the...

  7. On the benefit of high resolution and low aberrations for in-die mask registration metrology

    NASA Astrophysics Data System (ADS)

    Beyer, Dirk; Seidel, Dirk; Heisig, Sven; Steinert, Steffen; Töpfer, Susanne; Scherübl, Thomas; Hetzler, Jochen

    2014-10-01

    With the introduction of complex lithography schemes like double and multi - patterning and new design principles like gridded designs with cut masks the requirements for mask to mask overlay have increased dramatically. Still, there are some good news too for the mask industry since more mask are needed and qualified. Although always confronted with throughput demands, latest writing tool developments are able to keep pace with ever increasing pattern placement specs not only for global signatures but for in-die features within the active area. Placement specs less than 3nm (max. 3 Sigma) are expected and needed in all cases in order to keep the mask contribution to the overall overlay budget at an accepted level. The qualification of these masks relies on high precision metrology tools which have to fulfill stringent metrology as well as resolution constrains at the same time. Furthermore, multi-patterning and gridded designs with pinhole type cut masks are drivers for a paradigm shift in registration metrology from classical registration crosses to in-die registration metrology on production features. These requirements result in several challenges for registration metrology tools. The resolution of the system must be sufficiently high to resolve small production features. At the same time tighter repeatability is required. Furthermore, tool induced shift (TIS) limit the accuracy of in-die measurements. This paper discusses and demonstrates the importance of low illumination wavelength together with low aberrations for best contrast imaging for in-die registration metrology. Typical effects like tool induced shift are analyzed and evaluated using the ZEISS PROVE® registration metrology tool. Additionally, we will address performance gains when going to higher resolution. The direct impact on repeatability for small features by registration measurements will be discussed as well.

  8. Concepts for on-board satellite image registration, volume 1

    NASA Technical Reports Server (NTRS)

    Ruedger, W. H.; Daluge, D. R.; Aanstoos, J. V.

    1980-01-01

    The NASA-NEEDS program goals present a requirement for on-board signal processing to achieve user-compatible, information-adaptive data acquisition. One very specific area of interest is the preprocessing required to register imaging sensor data which have been distorted by anomalies in subsatellite-point position and/or attitude control. The concepts and considerations involved in using state-of-the-art positioning systems such as the Global Positioning System (GPS) in concert with state-of-the-art attitude stabilization and/or determination systems to provide the required registration accuracy are discussed with emphasis on assessing the accuracy to which a given image picture element can be located and identified, determining those algorithms required to augment the registration procedure and evaluating the technology impact on performing these procedures on-board the satellite.

  9. User Registration Systems for Distributed Systems

    NASA Astrophysics Data System (ADS)

    Murphy, K. J.; Cechini, M.; Pilone, D.; Mitchell, A.

    2010-12-01

    As NASA’s Earth Observing System Data and Information System (EOSDIS) systems have evolved over the years, most of the EOSDIS data are now available to users via anonymous on-line access. Although the changes have improved the dissemination efficiency of earth science data, the anonymous access has made it difficult to characterize users, capture metrics on the value of EOSDIS and provide customized services that benefit users. As the number of web-based applications continues to grow, data centers and application providers have implemented their own user registration systems and provided new tools and interfaces for their registered users. This has led to the creation of independent registration systems for accessing data and interacting with online tools and services. The user profile information maintained at each of these registration systems is not consistent and the registration enforcement varies by system as well. This problem is in no way unique to EOSDIS and represents a general challenge to the distributed computing community. In a study done in 2007(http://www2007.org/papers/paper620.pd), the average user has approximately 7 passwords for about 25 accounts and enters a password 8 times a day. These numbers have only increased in the last three years. To try and address this, a number of solutions have been offered including Single Sign-On solutions using a common backend like Microsoft Active Directory or an LDAP server, trust based identity providers like OpenID, and various forms of authorization delegation like OAuth or SAML/XACML. This talk discusses the differences between authentication and authorization, the state of the more popular user registration solutions available for distributed use, and some of the technical and policy drivers that need to be considered when incorporating a user registration system into your application.

  10. Public Attitudes toward Sexual Offenders and Sex Offender Registration

    ERIC Educational Resources Information Center

    Kernsmith, Poco D.; Craun, Sarah W.; Foster, Jonathan

    2009-01-01

    This study explores the relationship between fear of various types of sexual offenders and a belief that those sexual offenders should be subject to sex offender registration. We hypothesized that those who offend against children would elicit the most fear; consequently, the most feared offenders would be rated as most requiring registration. As…

  11. 27 CFR 20.133 - Registration of persons trafficking in articles.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Registration of persons trafficking in articles. 20.133 Section 20.133 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... Requirements Relating to Articles § 20.133 Registration of persons trafficking in articles. (a) Upon written...

  12. 37 CFR 7.11 - Requirements for international application originating from the United States.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... application and/or registration is depicted in black and white and the basic application or registration does... and white. (ii) If the mark in the basic application or registration is depicted in black and white and includes a color claim, the international application must include both a black and white...

  13. 17 CFR 1.12 - Maintenance of minimum financial requirements by futures commission merchants and introducing...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... commission merchant or who files an application for registration as a futures commission merchant, and each person registered as an introducing broker or who files an application for registration as an introducing... pursuant to, or who has filed concurrently with its application for registration, a guarantee agreement and...

  14. 17 CFR 1.12 - Maintenance of minimum financial requirements by futures commission merchants and introducing...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... commission merchant or who files an application for registration as a futures commission merchant, and each person registered as an introducing broker or who files an application for registration as an introducing... pursuant to, or who has filed concurrently with its application for registration, a guarantee agreement and...

  15. 17 CFR 1.12 - Maintenance of minimum financial requirements by futures commission merchants and introducing...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... commission merchant or who files an application for registration as a futures commission merchant, and each person registered as an introducing broker or who files an application for registration as an introducing... pursuant to, or who has filed concurrently with its application for registration, a guarantee agreement and...

  16. 17 CFR 1.12 - Maintenance of minimum financial requirements by futures commission merchants and introducing...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... commission merchant or who files an application for registration as a futures commission merchant, and each person registered as an introducing broker or who files an application for registration as an introducing... pursuant to, or who has filed concurrently with its application for registration, a guarantee agreement and...

  17. Efficient Method for Scalable Registration of Remote Sensing Images

    NASA Astrophysics Data System (ADS)

    Prouty, R.; LeMoigne, J.; Halem, M.

    2017-12-01

    The goal of this project is to build a prototype of a resource-efficient pipeline that will provide registration within subpixel accuracy of multitemporal Earth science data. Accurate registration of Earth-science data is imperative to proper data integration and seamless mosaicing of data from multiple times, sensors, and/or observation geometries. Modern registration methods make use of many arithmetic operations and sometimes require complete knowledge of the image domain. As such, while sensors become more advanced and are able to provide higher-resolution data, the memory resources required to properly register these data become prohibitive. The proposed pipeline employs a region of interest extraction algorithm in order to extract image subsets with high local feature density. These image subsets are then used to generate local solutions to the global registration problem. The local solutions are then 'globalized' to determine the deformation model that best solves the registration problem. The region of interest extraction and globalization routines are tested for robustness among the variety of scene-types and spectral locations provided by Earth-observing instruments such as Landsat, MODIS, or ASTER.

  18. Interface control document between the NASA Goddard Space Flight Center (GSFC) and Department of Interior EROS Data Center (EDC) for LANDSAT-D. Thematic mapper high resolution 241 mm film

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The 241 mm photographic product produced by the Goddard Space Flight Center Data Management System for LANDSAT-D is described. Film type and format, image dimensions, frame ID, gray scale, resolution patterns, registration marks, etc. are addressed.

  19. 78 FR 56708 - Announcement of Requirements and Registration for Game On!: HIV/STD Prevention Mobile Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... Requirements and Registration for Game On!: HIV/ STD Prevention Mobile Application (App) Video Game Challenge... Services (HHS) announces the launch of the Game On!: HIV/STD Prevention Mobile Application (App) Video Game Challenge. We invite video game developers to create an original, innovative, and highly entertaining game...

  20. 75 FR 66413 - 30-Day Notice of Proposed Information Collection: Exchange Programs Alumni Web Site Registration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ...: Exchange Programs Alumni Web Site Registration, DS-7006 ACTION: Notice of request for public comment and... Collection The Exchange Programs Alumni Web site requires information to process users' voluntary requests for participation in the Web site. Other than contact information, which is required for website...

  1. 17 CFR 37.5 - Procedures for registration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... contract market that it meets: (A) The requirements for trading of section 5a(b) of the Act; and (B) The... demonstrate that it satisfies the requirements for trading and the criteria for registration of sections 5a(b...) A copy of any documents describing the applicant's legal status and governance structure; (D) An...

  2. 17 CFR 37.5 - Procedures for registration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... contract market that it meets: (A) The requirements for trading of section 5a(b) of the Act; and (B) The... demonstrate that it satisfies the requirements for trading and the criteria for registration of sections 5a(b...) A copy of any documents describing the applicant's legal status and governance structure; (D) An...

  3. 78 FR 41800 - Announcement of Requirements and Registration for “I VetoViolence Because . . .”: Teen Dating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-11

    ... Requirements and Registration for ``I VetoViolence Because . . .'': Teen Dating Violence Prevention Public...) located within the Department of Health and Human Services (HHS) launches the ``I VetoViolence Because . . .'': Teen Dating Violence Prevention Public Service Announcement Contest. The purpose of the contest is to...

  4. 49 CFR 368.7 - Requirement to carry certificate of registration in the vehicle.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Requirement to carry certificate of registration in the vehicle. 368.7 Section 368.7 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS APPLICATION FOR A...

  5. 77 FR 40364 - Announcement of Requirements and Registration for Million Hearts TM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... Requirements and Registration for Million Hearts TM Caregiver Video Challenge AGENCY: Centers for Disease... announces the launch of The Million Hearts TM Caregiver Video Challenge. We invite people who play a role in... their stories of caregiving by creating original, compelling videos that are less than 2 minutes long...

  6. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Information required for establishment registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... the manufacturer issued by the Center for Biologics Evaluation and Research, Food and Drug...

  7. 21 CFR 607.25 - Information required for establishment registration and blood product listing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Information required for establishment registration and blood product listing. 607.25 Section 607.25 Food and Drugs FOOD AND DRUG ADMINISTRATION... the manufacturer issued by the Center for Biologics Evaluation and Research, Food and Drug...

  8. Coarse Point Cloud Registration by Egi Matching of Voxel Clusters

    NASA Astrophysics Data System (ADS)

    Wang, Jinhu; Lindenbergh, Roderik; Shen, Yueqian; Menenti, Massimo

    2016-06-01

    Laser scanning samples the surface geometry of objects efficiently and records versatile information as point clouds. However, often more scans are required to fully cover a scene. Therefore, a registration step is required that transforms the different scans into a common coordinate system. The registration of point clouds is usually conducted in two steps, i.e. coarse registration followed by fine registration. In this study an automatic marker-free coarse registration method for pair-wise scans is presented. First the two input point clouds are re-sampled as voxels and dimensionality features of the voxels are determined by principal component analysis (PCA). Then voxel cells with the same dimensionality are clustered. Next, the Extended Gaussian Image (EGI) descriptor of those voxel clusters are constructed using significant eigenvectors of each voxel in the cluster. Correspondences between clusters in source and target data are obtained according to the similarity between their EGI descriptors. The random sampling consensus (RANSAC) algorithm is employed to remove outlying correspondences until a coarse alignment is obtained. If necessary, a fine registration is performed in a final step. This new method is illustrated on scan data sampling two indoor scenarios. The results of the tests are evaluated by computing the point to point distance between the two input point clouds. The presented two tests resulted in mean distances of 7.6 mm and 9.5 mm respectively, which are adequate for fine registration.

  9. 37 CFR 2.161 - Requirements for a complete affidavit or declaration of continued use or excusable nonuse.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the registration number; (d)(1) Include the fee required by § 2.6 for each class of goods or services... period under section 8(a)(3) of the Act, include the grace period surcharge per class required by § 2.6; (3) If at least one fee is submitted for a multi-class registration, but the class(es) to which the...

  10. Antimicrobial Pesticide Use Site Index

    EPA Pesticide Factsheets

    This Use Site Index provides guidance to assist applicants for antimicrobial pesticide registration by helping them identify the data requirements necessary to register a pesticide or support their product registrations.

  11. Increasing the automation of a 2D-3D registration system.

    PubMed

    Varnavas, Andreas; Carrell, Tom; Penney, Graeme

    2013-02-01

    Routine clinical use of 2D-3D registration algorithms for Image Guided Surgery remains limited. A key aspect for routine clinical use of this technology is its degree of automation, i.e., the amount of necessary knowledgeable interaction between the clinicians and the registration system. Current image-based registration approaches usually require knowledgeable manual interaction during two stages: for initial pose estimation and for verification of produced results. We propose four novel techniques, particularly suited to vertebra-based registration systems, which can significantly automate both of the above stages. Two of these techniques are based upon the intraoperative "insertion" of a virtual fiducial marker into the preoperative data. The remaining two techniques use the final registration similarity value between multiple CT vertebrae and a single fluoroscopy vertebra. The proposed methods were evaluated with data from 31 operations (31 CT scans, 419 fluoroscopy images). Results show these methods can remove the need for manual vertebra identification during initial pose estimation, and were also very effective for result verification, producing a combined true positive rate of 100% and false positive rate equal to zero. This large decrease in required knowledgeable interaction is an important contribution aiming to enable more widespread use of 2D-3D registration technology.

  12. Hybrid registration of PET/CT in thoracic region with pre-filtering PET sinogram

    NASA Astrophysics Data System (ADS)

    Mokri, S. S.; Saripan, M. I.; Marhaban, M. H.; Nordin, A. J.; Hashim, S.

    2015-11-01

    The integration of physiological (PET) and anatomical (CT) images in cancer delineation requires an accurate spatial registration technique. Although hybrid PET/CT scanner is used to co-register these images, significant misregistrations exist due to patient and respiratory/cardiac motions. This paper proposes a hybrid feature-intensity based registration technique for hybrid PET/CT scanner. First, simulated PET sinogram was filtered with a 3D hybrid mean-median before reconstructing the image. The features were then derived from the segmented structures (lung, heart and tumor) from both images. The registration was performed based on modified multi-modality demon registration with multiresolution scheme. Apart from visual observations improvements, the proposed registration technique increased the normalized mutual information index (NMI) between the PET/CT images after registration. All nine tested datasets show marked improvements in mutual information (MI) index than free form deformation (FFD) registration technique with the highest MI increase is 25%.

  13. Three-dimensional nonrigid landmark-based magnetic resonance to transrectal ultrasound registration for image-guided prostate biopsy.

    PubMed

    Sun, Yue; Qiu, Wu; Yuan, Jing; Romagnoli, Cesare; Fenster, Aaron

    2015-04-01

    Registration of three-dimensional (3-D) magnetic resonance (MR) to 3-D transrectal ultrasound (TRUS) prostate images is an important step in the planning and guidance of 3-D TRUS guided prostate biopsy. In order to accurately and efficiently perform the registration, a nonrigid landmark-based registration method is required to account for the different deformations of the prostate when using these two modalities. We describe a nonrigid landmark-based method for registration of 3-D TRUS to MR prostate images. The landmark-based registration method first makes use of an initial rigid registration of 3-D MR to 3-D TRUS images using six manually placed approximately corresponding landmarks in each image. Following manual initialization, the two prostate surfaces are segmented from 3-D MR and TRUS images and then nonrigidly registered using the following steps: (1) rotationally reslicing corresponding segmented prostate surfaces from both 3-D MR and TRUS images around a specified axis, (2) an approach to find point correspondences on the surfaces of the segmented surfaces, and (3) deformation of the surface of the prostate in the MR image to match the surface of the prostate in the 3-D TRUS image and the interior using a thin-plate spline algorithm. The registration accuracy was evaluated using 17 patient prostate MR and 3-D TRUS images by measuring the target registration error (TRE). Experimental results showed that the proposed method yielded an overall mean TRE of [Formula: see text] for the rigid registration and [Formula: see text] for the nonrigid registration, which is favorably comparable to a clinical requirement for an error of less than 2.5 mm. A landmark-based nonrigid 3-D MR-TRUS registration approach is proposed, which takes into account the correspondences on the prostate surface, inside the prostate, as well as the centroid of the prostate. Experimental results indicate that the proposed method yields clinically sufficient accuracy.

  14. 49 CFR 107.616 - Payment procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... Box 530273, Atlanta, GA 30353-0273, or submit the statement and payment electronically through the... required fees for up to three registration years by filing one complete and accurate registration statement...

  15. Biomechanical deformable image registration of longitudinal lung CT images using vessel information

    NASA Astrophysics Data System (ADS)

    Cazoulat, Guillaume; Owen, Dawn; Matuszak, Martha M.; Balter, James M.; Brock, Kristy K.

    2016-07-01

    Spatial correlation of lung tissue across longitudinal images, as the patient responds to treatment, is a critical step in adaptive radiotherapy. The goal of this work is to expand a biomechanical model-based deformable registration algorithm (Morfeus) to achieve accurate registration in the presence of significant anatomical changes. Six lung cancer patients previously treated with conventionally fractionated radiotherapy were retrospectively evaluated. Exhale CT scans were obtained at treatment planning and following three weeks of treatment. For each patient, the planning CT was registered to the follow-up CT using Morfeus, a biomechanical model-based deformable registration algorithm. To model the complex response of the lung, an extension to Morfeus has been developed: an initial deformation was estimated with Morfeus consisting of boundary conditions on the chest wall and incorporating a sliding interface with the lungs. It was hypothesized that the addition of boundary conditions based on vessel tree matching would provide a robust reduction of the residual registration error. To achieve this, the vessel trees were segmented on the two images by thresholding a vesselness image based on the Hessian matrix’s eigenvalues. For each point on the reference vessel tree centerline, the displacement vector was estimated by applying a variant of the Demons registration algorithm between the planning CT and the deformed follow-up CT. An expert independently identified corresponding landmarks well distributed in the lung to compute target registration errors (TRE). The TRE was: 5.8+/- 2.9 , 3.4+/- 2.3 and 1.6+/- 1.3 mm after rigid registration, Morfeus and Morfeus with boundary conditions on the vessel tree, respectively. In conclusion, the addition of boundary conditions on the vessels significantly improved the accuracy in modeling the response of the lung and tumor over the course of radiotherapy. Minimizing and modeling these geometrical uncertainties will enable future plan adaptation strategies.

  16. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Award term-Reporting and registration requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE...

  17. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Award term-Reporting and registration requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE...

  18. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Award term-Reporting and registration requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE...

  19. 2 CFR 176.50 - Award term-Reporting and registration requirements under section 1512 of the Recovery Act.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Award term-Reporting and registration requirements under section 1512 of the Recovery Act. 176.50 Section 176.50 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE...

  20. 76 FR 66855 - United States Savings Bonds, Series EE, HH and I

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    .... 351.43 to read as follows: Sec. 351.43 Are Taxpayer Identification Numbers (TINs) required for the... owner's TIN is not known, the TIN of the purchaser must be included in the registration of the bond. 0 6.... 359.28 Are Taxpayer Identification Numbers (TINs) required for the registration of definitive series I...

  1. 17 CFR 270.8b-12 - Requirements as to paper, printing and language.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., printing and language. 270.8b-12 Section 270.8b-12 Commodity and Securities Exchanges SECURITIES AND... Requirements as to paper, printing and language. (a) Registration statements and reports shall be filed on good... as such on photocopies. (d) The body of all printed registration statements and reports and all notes...

  2. 17 CFR 270.8b-12 - Requirements as to paper, printing and language.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., printing and language. 270.8b-12 Section 270.8b-12 Commodity and Securities Exchanges SECURITIES AND... Requirements as to paper, printing and language. (a) Registration statements and reports shall be filed on good.... (d) The body of all printed registration statements and reports and all notes to financial statements...

  3. 17 CFR 270.8b-12 - Requirements as to paper, printing and language.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., printing and language. 270.8b-12 Section 270.8b-12 Commodity and Securities Exchanges SECURITIES AND... Requirements as to paper, printing and language. (a) Registration statements and reports shall be filed on good... as such on photocopies. (d) The body of all printed registration statements and reports and all notes...

  4. 49 CFR 385.605 - New entrant registration driver's license and drug and alcohol testing requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... America-Domiciled Carriers § 385.605 New entrant registration driver's license and drug and alcohol testing requirements. (a) A non-North America-domiciled motor carrier must use only drivers who possess a... Federal de Conductor—to operate its vehicles in the United States. (b) A non-North America-domiciled motor...

  5. 49 CFR 385.605 - New entrant registration driver's license and drug and alcohol testing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... America-Domiciled Carriers § 385.605 New entrant registration driver's license and drug and alcohol testing requirements. (a) A non-North America-domiciled motor carrier must use only drivers who possess a... Federal de Conductor—to operate its vehicles in the United States. (b) A non-North America-domiciled motor...

  6. 49 CFR 385.605 - New entrant registration driver's license and drug and alcohol testing requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... America-Domiciled Carriers § 385.605 New entrant registration driver's license and drug and alcohol testing requirements. (a) A non-North America-domiciled motor carrier must use only drivers who possess a... Federal de Conductor—to operate its vehicles in the United States. (b) A non-North America-domiciled motor...

  7. 49 CFR 385.605 - New entrant registration driver's license and drug and alcohol testing requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... America-Domiciled Carriers § 385.605 New entrant registration driver's license and drug and alcohol testing requirements. (a) A non-North America-domiciled motor carrier must use only drivers who possess a... Federal de Conductor—to operate its vehicles in the United States. (b) A non-North America-domiciled motor...

  8. 49 CFR 385.605 - New entrant registration driver's license and drug and alcohol testing requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... America-Domiciled Carriers § 385.605 New entrant registration driver's license and drug and alcohol testing requirements. (a) A non-North America-domiciled motor carrier must use only drivers who possess a... Federal de Conductor—to operate its vehicles in the United States. (b) A non-North America-domiciled motor...

  9. Research on land registration procedure ontology of China

    NASA Astrophysics Data System (ADS)

    Zhao, Zhongjun; Du, Qingyun; Zhang, Weiwei; Liu, Tao

    2009-10-01

    Land registration is public act which is to record the state-owned land use right, collective land ownership, collective land use right and land mortgage, servitude, as well as other land rights required the registration according to laws and regulations onto land registering books. Land registration is one of the important government affairs , so it is very important to standardize, optimize and humanize the process of land registration. The management works of organization are realized through a variety of workflows. Process knowledge is in essence a kind of methodology knowledge and a system which including the core and the relational knowledge. In this paper, the ontology is introduced into the field of land registration and management, trying to optimize the flow of land registration, to promote the automation-building and intelligent Service of land registration affairs, to provide humanized and intelligent service for multi-types of users . This paper tries to build land registration procedure ontology by defining the land registration procedure ontology's key concepts which represent the kinds of processes of land registration and mapping the kinds of processes to OWL-S. The land registration procedure ontology shall be the start and the basis of the Web service.

  10. [Accurate 3D free-form registration between fan-beam CT and cone-beam CT].

    PubMed

    Liang, Yueqiang; Xu, Hongbing; Li, Baosheng; Li, Hongsheng; Yang, Fujun

    2012-06-01

    Because the X-ray scatters, the CT numbers in cone-beam CT cannot exactly correspond to the electron densities. This, therefore, results in registration error when the intensity-based registration algorithm is used to register planning fan-beam CT and cone-beam CT. In order to reduce the registration error, we have developed an accurate gradient-based registration algorithm. The gradient-based deformable registration problem is described as a minimization of energy functional. Through the calculus of variations and Gauss-Seidel finite difference method, we derived the iterative formula of the deformable registration. The algorithm was implemented by GPU through OpenCL framework, with which the registration time was greatly reduced. Our experimental results showed that the proposed gradient-based registration algorithm could register more accurately the clinical cone-beam CT and fan-beam CT images compared with the intensity-based algorithm. The GPU-accelerated algorithm meets the real-time requirement in the online adaptive radiotherapy.

  11. 'Who does what' in the orthodontic workforce.

    PubMed

    Hodge, T; Parkin, N

    2015-02-16

    The contraction of the economy in the United Kingdom and constraints on the National Health Service (NHS) together with new opportunities for the delivery of orthodontic treatment has resulted in an increasing number of dental personnel across the different registrant groups. This article focuses on the changes that have taken place in the orthodontic workforce over the past decade. Although others help deliver orthodontic services such as material suppliers, treatment coordinators and those involved in marketing, this article will restrict itself to informing the reader specifically about which dental registrants are doing what at the clinical interface. How health professionals have developed their skills to undertake the role they play within the team and possible threats arising because of these changes are also discussed.

  12. Clinical trial registration and reporting: a survey of academic organizations in the United States.

    PubMed

    Mayo-Wilson, Evan; Heyward, James; Keyes, Anthony; Reynolds, Jesse; White, Sarah; Atri, Nidhi; Alexander, G Caleb; Omar, Audrey; Ford, Daniel E

    2018-05-02

    Many clinical trials conducted by academic organizations are not published, or are not published completely. Following the US Food and Drug Administration Amendments Act of 2007, "The Final Rule" (compliance date April 18, 2017) and a National Institutes of Health policy clarified and expanded trial registration and results reporting requirements. We sought to identify policies, procedures, and resources to support trial registration and reporting at academic organizations. We conducted an online survey from November 21, 2016 to March 1, 2017, before organizations were expected to comply with The Final Rule. We included active Protocol Registration and Results System (PRS) accounts classified by ClinicalTrials.gov as a "University/Organization" in the USA. PRS administrators manage information on ClinicalTrials.gov. We invited one PRS administrator to complete the survey for each organization account, which was the unit of analysis. Eligible organization accounts (N = 783) included 47,701 records (e.g., studies) in August 2016. Participating organizations (366/783; 47%) included 40,351/47,701 (85%) records. Compared with other organizations, Clinical and Translational Science Award (CTSA) holders, cancer centers, and large organizations were more likely to participate. A minority of accounts have a registration (156/366; 43%) or results reporting policy (129/366; 35%). Of those with policies, 15/156 (11%) and 49/156 (35%) reported that trials must be registered before institutional review board approval is granted or before beginning enrollment, respectively. Few organizations use computer software to monitor compliance (68/366; 19%). One organization had penalized an investigator for non-compliance. Among the 287/366 (78%) accounts reporting that they allocate staff to fulfill ClinicalTrials.gov registration and reporting requirements, the median number of full-time equivalent staff is 0.08 (interquartile range = 0.02-0.25). Because of non-response and social desirability, this could be a "best case" scenario. Before the compliance date for The Final Rule, some academic organizations had policies and resources that facilitate clinical trial registration and reporting. Most organizations appear to be unprepared to meet the new requirements. Organizations could enact the following: adopt policies that require trial registration and reporting, allocate resources (e.g., staff, software) to support registration and reporting, and ensure there are consequences for investigators who do not follow standards for clinical research.

  13. Analysis of deformable image registration accuracy using computational modeling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhong Hualiang; Kim, Jinkoo; Chetty, Indrin J.

    2010-03-15

    Computer aided modeling of anatomic deformation, allowing various techniques and protocols in radiation therapy to be systematically verified and studied, has become increasingly attractive. In this study the potential issues in deformable image registration (DIR) were analyzed based on two numerical phantoms: One, a synthesized, low intensity gradient prostate image, and the other a lung patient's CT image data set. Each phantom was modeled with region-specific material parameters with its deformation solved using a finite element method. The resultant displacements were used to construct a benchmark to quantify the displacement errors of the Demons and B-Spline-based registrations. The results showmore » that the accuracy of these registration algorithms depends on the chosen parameters, the selection of which is closely associated with the intensity gradients of the underlying images. For the Demons algorithm, both single resolution (SR) and multiresolution (MR) registrations required approximately 300 iterations to reach an accuracy of 1.4 mm mean error in the lung patient's CT image (and 0.7 mm mean error averaged in the lung only). For the low gradient prostate phantom, these algorithms (both SR and MR) required at least 1600 iterations to reduce their mean errors to 2 mm. For the B-Spline algorithms, best performance (mean errors of 1.9 mm for SR and 1.6 mm for MR, respectively) on the low gradient prostate was achieved using five grid nodes in each direction. Adding more grid nodes resulted in larger errors. For the lung patient's CT data set, the B-Spline registrations required ten grid nodes in each direction for highest accuracy (1.4 mm for SR and 1.5 mm for MR). The numbers of iterations or grid nodes required for optimal registrations depended on the intensity gradients of the underlying images. In summary, the performance of the Demons and B-Spline registrations have been quantitatively evaluated using numerical phantoms. The results show that parameter selection for optimal accuracy is closely related to the intensity gradients of the underlying images. Also, the result that the DIR algorithms produce much lower errors in heterogeneous lung regions relative to homogeneous (low intensity gradient) regions, suggests that feature-based evaluation of deformable image registration accuracy must be viewed cautiously.« less

  14. Registration Review Schedules

    EPA Pesticide Factsheets

    This schedule indicates plans for completion of risk assessments, proposed interim decisions and interim decisions for pesticides in the Registration Review program, EPA reviews all registered pesticides at least every 15 years as required by FIFRA.

  15. Data Management Systems (DMS): Complex data types study. Volume 1: Appendices A-B. Volume 2: Appendices C1-C5. Volume 3: Appendices D1-D3 and E

    NASA Technical Reports Server (NTRS)

    Leibfried, T. F., Jr.; Davari, Sadegh; Natarajan, Swami; Zhao, Wei

    1992-01-01

    Two categories were chosen for study: the issue of using a preprocessor on Ada code of Application Programs which would interface with the Run-Time Object Data Base Standard Services (RODB STSV), the intent was to catch and correct any mis-registration errors of the program coder between the user declared Objects, their types, their addresses, and the corresponding RODB definitions; and RODB STSV Performance Issues and Identification of Problems with the planned methods for accessing Primitive Object Attributes, this included the study of an alternate storage scheme to the 'store objects by attribute' scheme in the current design of the RODB. The study resulted in essentially three separate documents, an interpretation of the system requirements, an assessment of the preliminary design, and a detailing of the components of a detailed design.

  16. CSPP CDX Registration Guide

    EPA Pesticide Factsheets

    CDX allows users submitting data to the EPA to register for the specific program of interest. This Guide describes the registration process and information requirements associated with Submissions for the Chemical Safety and Pesticide Programs (CSPP).

  17. 27 CFR 19.151 - General requirements for registration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... law, operations as a distiller, warehouseman, or processor may be conducted only on the bonded... conduct at such plant operations as a distiller, as a warehouseman, or as both. (c) Registration. Each...

  18. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) State whether it believes that additional data are needed and, if so, describe what is needed. A FIFRA 3(c)(2)(B) notice requiring such data may be issued in conjunction with a proposed or final decision... remain open until all actions required in the final decision on the registration review case have been...

  19. 40 CFR 155.58 - Procedures for issuing a decision on a registration review case.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) State whether it believes that additional data are needed and, if so, describe what is needed. A FIFRA 3(c)(2)(B) notice requiring such data may be issued in conjunction with a proposed or final decision... remain open until all actions required in the final decision on the registration review case have been...

  20. 17 CFR 239.37 - Form F-7, for registration under the Securities Act of 1933 of securities of certain Canadian...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... “business combination”), the registrant shall be deemed to meet the 36-month reporting requirement and the... subject to such requirements at the time of the business combination, in each case equals at least 36... reporting history calculation if the reporting histories of predecessors whose assets and gross revenues...

  1. 17 CFR 240.12h-1 - Exemptions from registration under section 12(g) of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Exemptions from registration... optionholder until the issuer becomes subject to the reporting requirements of section 13 or 15(d) of the Act... to the reporting requirements of section 13 or 15(d) of the Act or is no longer relying on the...

  2. A Web interface generator for molecular biology programs in Unix.

    PubMed

    Letondal, C

    2001-01-01

    Almost all users encounter problems using sequence analysis programs. Not only are they difficult to learn because of the parameters, syntax and semantic, but many are different. That is why we have developed a Web interface generator for more than 150 molecular biology command-line driven programs, including: phylogeny, gene prediction, alignment, RNA, DNA and protein analysis, motif discovery, structure analysis and database searching programs. The generator uses XML as a high-level description language of the legacy software parameters. Its aim is to provide users with the equivalent of a basic Unix environment, with program combination, customization and basic scripting through macro registration. The program has been used for three years by about 15000 users throughout the world; it has recently been installed on other sites and evaluated as a standard user interface for EMBOSS programs.

  3. Research competency and specialist registration: Quo vadis ?

    PubMed

    Szabo, C P; Ramlall, S

    2016-12-01

    The requirement of 'research completion' as necessary for specialist registration with the Health Professions Council of South Africa (HPCSA) has recently been subject to legal action, with a court order potentially shifting requirements beyond those envisaged by the HPCSA. The research requirement is congruent with National Department of Health strategy in this regard, i.e. the strengthening of research as a stated priority. While the expectation of research competency is not in itself contentious, the capacity of institutions and the ability of registrars to facilitate and complete, respectively, have brought the issue into focus. Specifically, the apparent discrepancy between a court order and a regulation needs to be resolved to ensure that specialist registration is not unduly hampered, while ensuring that a potentially important contributor to a national priority is not prejudiced.

  4. 17 CFR 1.66 - No-action positions with respect to floor traders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., in light of the Congressional mandate requiring registration of floor traders under the Act, the... granted or denied registration under the Act, or on June 11, 1993, whichever comes earliest: Provided...

  5. 17 CFR 1.66 - No-action positions with respect to floor traders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., in light of the Congressional mandate requiring registration of floor traders under the Act, the... granted or denied registration under the Act, or on June 11, 1993, whichever comes earliest: Provided...

  6. 48 CFR 4.1803 - Verifying CAGE codes prior to award.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... registration in the System for Award Management (SAM). Active registrations in SAM have had the associated CAGE codes verified. (b) For entities not required to be registered in SAM, the contracting officer shall...

  7. 21 CFR 1309.24 - Waiver of registration requirement for certain activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... limited to the distribution of red phosphorus, white phosphorus, or hypophosphorous acid (and its salts... registration is waived for any person whose distribution of red phosphorus or white phosphorus is limited...

  8. 21 CFR 1309.24 - Waiver of registration requirement for certain activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... limited to the distribution of red phosphorus, white phosphorus, or hypophosphorous acid (and its salts... registration is waived for any person whose distribution of red phosphorus or white phosphorus is limited...

  9. Alternative Fuels Data Center

    Science.gov Websites

    Alternative Fuel Vehicle (AFV) Registration A fee of $75 is required for the registration of an AFV state motor fuel tax laws. Compressed natural gas, liquefied natural gas, and propane are not subject to

  10. 40 CFR 164.120 - Notification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS RULES OF PRACTICE... REGISTER, CANCELLATIONS OF REGISTRATIONS, CHANGES OF CLASSIFICATIONS, SUSPENSIONS OF REGISTRATIONS AND... imminent hazard during the time required for cancellation or change in classification proceedings, but that...

  11. 40 CFR 164.120 - Notification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS RULES OF PRACTICE... REGISTER, CANCELLATIONS OF REGISTRATIONS, CHANGES OF CLASSIFICATIONS, SUSPENSIONS OF REGISTRATIONS AND... imminent hazard during the time required for cancellation or change in classification proceedings, but that...

  12. Comparison of manual and automatic MR-CT registration for radiotherapy of prostate cancer.

    PubMed

    Korsager, Anne Sofie; Carl, Jesper; Riis Østergaard, Lasse

    2016-05-08

    In image-guided radiotherapy (IGRT) of prostate cancer, delineation of the clini-cal target volume (CTV) often relies on magnetic resonance (MR) because of its good soft-tissue visualization. Registration of MR and computed tomography (CT) is required in order to add this accurate delineation to the dose planning CT. An automatic approach for local MR-CT registration of the prostate has previously been developed using a voxel property-based registration as an alternative to a manual landmark-based registration. The aim of this study is to compare the two registration approaches and to investigate the clinical potential for replacing the manual registration with the automatic registration. Registrations and analysis were performed for 30 prostate cancer patients treated with IGRT using a Ni-Ti prostate stent as a fiducial marker. The comparison included computing translational and rotational differences between the approaches, visual inspection, and computing the overlap of the CTV. The computed mean translational difference was 1.65, 1.60, and 1.80mm and the computed mean rotational difference was 1.51°, 3.93°, and 2.09° in the superior/inferior, anterior/posterior, and medial/lateral direction, respectively. The sensitivity of overlap was 87%. The results demonstrate that the automatic registration approach performs registrations comparable to the manual registration.

  13. Components for Maintaining and Publishing Earth Science Vocabularies

    NASA Astrophysics Data System (ADS)

    Cox, S. J. D.; Yu, J.

    2014-12-01

    Shared vocabularies are an important aid to geoscience data interoperability. Many organizations maintain useful vocabularies, with Geologic Surveys having a particularly long history of vocabulary and lexicon development. However, the mode of publication is heterogeneous, ranging from PDFs and HTML web pages, spreadsheets and CSV, through various user-interfaces and APIs. Update and maintenance ranges from tightly-governed and externally opaque, through various community processes, all the way to crowd-sourcing ('folksonomies'). A general expectation, however, is for greater harmonization and vocabulary re-use. In order to be successful this requires (a) standardized content formalization and APIs (b) transparent content maintenance and versioning. We have been trialling a combination of software dealing with registration, search and linking. SKOS is designed for formalizing multi-lingual, hierarchical vocabularies, and has been widely adopted in earth and environmental sciences. SKOS is an RDF vocabulary, for which SPARQL is the standard low-level API. However, for interoperability between SKOS vocabulary sources, a SKOS-based API (i.e. based on the SKOS predicates prefLabel, broader, narrower, etc) is required. We have developed SISSvoc for this purpose, and used it to deploy a number of vocabularies on behalf of the IUGS, ICS, NERC, OGC, the Australian Government, and CSIRO projects. SISSvoc Search provides simple search UI on top of one or more SISSvoc sources. Content maintenance is composed of many elements, including content-formalization, definition-update, and mappings to related vocabularies. Typically there is a degree of expert judgement required. In order to provide confidence in users, two requirements are paramount: (i) once published, a URI that denotes a vocabulary item must remain dereferenceable; (ii) the history and status of the content denoted by a URI must be available. These requirements match the standard 'registration' paradigm which is implemented in the Linked Data Registry, which is currently used by WMO and the UK Environment Agency for publication of vocabularies. Together, these components provide a powerful and flexible system for providing earth science vocabularies for the community, consistent with semantic web and linked-data principles.

  14. A Review on Medical Image Registration as an Optimization Problem

    PubMed Central

    Song, Guoli; Han, Jianda; Zhao, Yiwen; Wang, Zheng; Du, Huibin

    2017-01-01

    Objective: In the course of clinical treatment, several medical media are required by a phy-sician in order to provide accurate and complete information about a patient. Medical image registra-tion techniques can provide a richer diagnosis and treatment information to doctors and to provide a comprehensive reference source for the researchers involved in image registration as an optimization problem. Methods: The essence of image registration is associating two or more different images spatial asso-ciation, and getting the translation of their spatial relationship. For medical image registration, its pro-cess is not absolute. Its core purpose is finding the conversion relationship between different images. Result: The major step of image registration includes the change of geometrical dimensions, and change of the image of the combination, image similarity measure, iterative optimization and interpo-lation process. Conclusion: The contribution of this review is sort of related image registration research methods, can provide a brief reference for researchers about image registration. PMID:28845149

  15. Architecture Design of Healthcare Software-as-a-Service Platform for Cloud-Based Clinical Decision Support Service.

    PubMed

    Oh, Sungyoung; Cha, Jieun; Ji, Myungkyu; Kang, Hyekyung; Kim, Seok; Heo, Eunyoung; Han, Jong Soo; Kang, Hyunggoo; Chae, Hoseok; Hwang, Hee; Yoo, Sooyoung

    2015-04-01

    To design a cloud computing-based Healthcare Software-as-a-Service (SaaS) Platform (HSP) for delivering healthcare information services with low cost, high clinical value, and high usability. We analyzed the architecture requirements of an HSP, including the interface, business services, cloud SaaS, quality attributes, privacy and security, and multi-lingual capacity. For cloud-based SaaS services, we focused on Clinical Decision Service (CDS) content services, basic functional services, and mobile services. Microsoft's Azure cloud computing for Infrastructure-as-a-Service (IaaS) and Platform-as-a-Service (PaaS) was used. The functional and software views of an HSP were designed in a layered architecture. External systems can be interfaced with the HSP using SOAP and REST/JSON. The multi-tenancy model of the HSP was designed as a shared database, with a separate schema for each tenant through a single application, although healthcare data can be physically located on a cloud or in a hospital, depending on regulations. The CDS services were categorized into rule-based services for medications, alert registration services, and knowledge services. We expect that cloud-based HSPs will allow small and mid-sized hospitals, in addition to large-sized hospitals, to adopt information infrastructures and health information technology with low system operation and maintenance costs.

  16. A Demons algorithm for image registration with locally adaptive regularization.

    PubMed

    Cahill, Nathan D; Noble, J Alison; Hawkes, David J

    2009-01-01

    Thirion's Demons is a popular algorithm for nonrigid image registration because of its linear computational complexity and ease of implementation. It approximately solves the diffusion registration problem by successively estimating force vectors that drive the deformation toward alignment and smoothing the force vectors by Gaussian convolution. In this article, we show how the Demons algorithm can be generalized to allow image-driven locally adaptive regularization in a manner that preserves both the linear complexity and ease of implementation of the original Demons algorithm. We show that the proposed algorithm exhibits lower target registration error and requires less computational effort than the original Demons algorithm on the registration of serial chest CT scans of patients with lung nodules.

  17. 47 CFR 95.1402 - Special requirements for 406 MHz PLBs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...: SARSAT Beacon Registration, NOAA, NESDIS, E/SP3, Room 3320, FB-4, 5200 Auth Road, Suitland, Maryland... Administration (NOAA) whose address is: SARSAT Beacon Registration, NOAA, NESDIS, E/SP3, Room 3320, FB-4, 5200...

  18. 47 CFR 95.1402 - Special requirements for 406 MHz PLBs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...: SARSAT Beacon Registration, NOAA, NESDIS, E/SP3, Room 3320, FB-4, 5200 Auth Road, Suitland, Maryland... Administration (NOAA) whose address is: SARSAT Beacon Registration, NOAA, NESDIS, E/SP3, Room 3320, FB-4, 5200...

  19. 47 CFR 95.1402 - Special requirements for 406 MHz PLBs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...: SARSAT Beacon Registration, NOAA, NESDIS, E/SP3, Room 3320, FB-4, 5200 Auth Road, Suitland, Maryland... Administration (NOAA) whose address is: SARSAT Beacon Registration, NOAA, NESDIS, E/SP3, Room 3320, FB-4, 5200...

  20. 47 CFR 95.1402 - Special requirements for 406 MHz PLBs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...: SARSAT Beacon Registration, NOAA, NESDIS, E/SP3, Room 3320, FB-4, 5200 Auth Road, Suitland, Maryland... Administration (NOAA) whose address is: SARSAT Beacon Registration, NOAA, NESDIS, E/SP3, Room 3320, FB-4, 5200...

  1. Clinical trial transparency: a reassessment of industry compliance with clinical trial registration and reporting requirements in the United States

    PubMed Central

    Lassman, Scott M; Shopshear, Olivia M; Jazic, Ina; Ulrich, Jocelyn; Francer, Jeffrey

    2017-01-01

    Objective To evaluate the accuracy of a 2015 cross-sectional analysis published in the BMJ Open which reported that pharmaceutical industry compliance with clinical trial registration and results reporting requirements under US law was suboptimal and varied widely among companies. Design We performed a reassessment of the data reported in Miller et al to evaluate whether statutory compliance analyses and conclusions were valid. Data sources Information from the Dryad Digital Repository, ClinicalTrials.gov, Drugs@FDA and direct communications with sponsors. Main outcome measures Compliance with the clinical trial registration and results reporting requirements under the Food and Drug Administration Amendments Act (FDAAA). Results Industry compliance with FDAAA disclosure requirements was notably higher than reported by Miller et al. Among trials subject to FDAAA, Miller et al reported that, per drug, a median of 67% (middle 50% range: 0%–100%) of trials fully complied with registration and results reporting requirements. On reanalysis of the data, we found that a median of 100% (middle 50% range: 93%–100%) of clinical trials for a particular drug fully complied with the law. When looking at overall compliance at the trial level, our reassessment yields 94% timely registration and 90% timely results reporting among the 49 eligible trials, and an overall FDAAA compliance rate of 86%. Conclusions The claim by Miller et al that industry compliance is below legal standards is based on an analysis that relies on an incomplete dataset and an interpretation of FDAAA that requires disclosure of study results for drugs that have not yet been approved for any indication. On reanalysis using a different interpretation of FDAAA that focuses on whether results were disclosed within 30 days of drug approval, we found that industry compliance with US statutory disclosure requirements for the 15 reviewed drugs was consistently high. PMID:28942418

  2. Application of tolerance limits to the characterization of image registration performance.

    PubMed

    Fedorov, Andriy; Wells, William M; Kikinis, Ron; Tempany, Clare M; Vangel, Mark G

    2014-07-01

    Deformable image registration is used increasingly in image-guided interventions and other applications. However, validation and characterization of registration performance remain areas that require further study. We propose an analysis methodology for deriving tolerance limits on the initial conditions for deformable registration that reliably lead to a successful registration. This approach results in a concise summary of the probability of registration failure, while accounting for the variability in the test data. The (β, γ) tolerance limit can be interpreted as a value of the input parameter that leads to successful registration outcome in at least 100β% of cases with the 100γ% confidence. The utility of the methodology is illustrated by summarizing the performance of a deformable registration algorithm evaluated in three different experimental setups of increasing complexity. Our examples are based on clinical data collected during MRI-guided prostate biopsy registered using publicly available deformable registration tool. The results indicate that the proposed methodology can be used to generate concise graphical summaries of the experiments, as well as a probabilistic estimate of the registration outcome for a future sample. Its use may facilitate improved objective assessment, comparison and retrospective stress-testing of deformable.

  3. WE-H-202-04: Advanced Medical Image Registration Techniques

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Christensen, G.

    Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications. The state of the art in image registration will be presented from an engineering perspective. Translational clinical applications will also be discussed tomore » tie these new registration approaches together with imaging and radiation therapy applications in specific diseases such as cervical and lung cancers. Learning Objectives: To understand developing techniques and algorithms in deformable image registration that are likely to translate into clinical tools in the near future. To understand emerging imaging and radiation therapy clinical applications that require such new registration algorithms. Research supported in part by the National Institutes of Health under award numbers P01CA059827, R01CA166119, and R01CA166703. Disclosures: Phillips Medical systems (Hugo), Roger Koch (Christensen) support, Varian Medical Systems (Brock), licensing agreements from Raysearch (Brock) and Varian (Hugo).; K. Brock, Licensing Agreement - RaySearch Laboratories. Research Funding - Varian Medical Systems; G. Hugo, Research grant from National Institutes of Health, award number R01CA166119.; G. Christensen, Research support from NIH grants CA166119 and CA166703 and a gift from Roger Koch. There are no conflicts of interest.« less

  4. A spatiotemporal-based scheme for efficient registration-based segmentation of thoracic 4-D MRI.

    PubMed

    Yang, Y; Van Reeth, E; Poh, C L; Tan, C H; Tham, I W K

    2014-05-01

    Dynamic three-dimensional (3-D) (four-dimensional, 4-D) magnetic resonance (MR) imaging is gaining importance in the study of pulmonary motion for respiratory diseases and pulmonary tumor motion for radiotherapy. To perform quantitative analysis using 4-D MR images, segmentation of anatomical structures such as the lung and pulmonary tumor is required. Manual segmentation of entire thoracic 4-D MRI data that typically contains many 3-D volumes acquired over several breathing cycles is extremely tedious, time consuming, and suffers high user variability. This requires the development of new automated segmentation schemes for 4-D MRI data segmentation. Registration-based segmentation technique that uses automatic registration methods for segmentation has been shown to be an accurate method to segment structures for 4-D data series. However, directly applying registration-based segmentation to segment 4-D MRI series lacks efficiency. Here we propose an automated 4-D registration-based segmentation scheme that is based on spatiotemporal information for the segmentation of thoracic 4-D MR lung images. The proposed scheme saved up to 95% of computation amount while achieving comparable accurate segmentations compared to directly applying registration-based segmentation to 4-D dataset. The scheme facilitates rapid 3-D/4-D visualization of the lung and tumor motion and potentially the tracking of tumor during radiation delivery.

  5. Cortical surface registration using spherical thin-plate spline with sulcal lines and mean curvature as features.

    PubMed

    Park, Hyunjin; Park, Jun-Sung; Seong, Joon-Kyung; Na, Duk L; Lee, Jong-Min

    2012-04-30

    Analysis of cortical patterns requires accurate cortical surface registration. Many researchers map the cortical surface onto a unit sphere and perform registration of two images defined on the unit sphere. Here we have developed a novel registration framework for the cortical surface based on spherical thin-plate splines. Small-scale composition of spherical thin-plate splines was used as the geometric interpolant to avoid folding in the geometric transform. Using an automatic algorithm based on anisotropic skeletons, we extracted seven sulcal lines, which we then incorporated as landmark information. Mean curvature was chosen as an additional feature for matching between spherical maps. We employed a two-term cost function to encourage matching of both sulcal lines and the mean curvature between the spherical maps. Application of our registration framework to fifty pairwise registrations of T1-weighted MRI scans resulted in improved registration accuracy, which was computed from sulcal lines. Our registration approach was tested as an additional procedure to improve an existing surface registration algorithm. Our registration framework maintained an accurate registration over the sulcal lines while significantly increasing the cross-correlation of mean curvature between the spherical maps being registered. Copyright © 2012 Elsevier B.V. All rights reserved.

  6. BrachyView: Combining LDR seed positions with transrectal ultrasound imaging in a prostate gel phantom.

    PubMed

    Alnaghy, S; Cutajar, D L; Bucci, J A; Enari, K; Safavi-Naeini, M; Favoino, M; Tartaglia, M; Carriero, F; Jakubek, J; Pospisil, S; Lerch, M; Rosenfeld, A B; Petasecca, M

    2017-02-01

    BrachyView is a novel in-body imaging system which aims to provide LDR brachytherapy seeds position reconstruction within the prostate in real-time. The first prototype is presented in this study: the probe consists of a gamma camera featuring three single cone pinhole collimators embedded in a tungsten tube, above three, high resolution pixelated detectors (Timepix). The prostate was imaged with a TRUS system using a sagittal crystal with a 2.5mm slice thickness. Eleven needles containing a total of thirty 0.508U 125 I seeds were implanted under ultrasound guidance. A CT scan was used to localise the seed positions, as well as provide a reference when performing the image co-registration between the BrachyView coordinate system and the TRUS coordinate system. An in-house visualisation software interface was developed to provide a quantitative 3D reconstructed prostate based on the TRUS images and co-registered with the LDR seeds in situ. A rigid body image registration was performed between the BrachyView and TRUS systems, with the BrachyView and CT-derived source locations compared. The reconstructed seed positions determined by the BrachyView probe showed a maximum discrepancy of 1.78mm, with 75% of the seeds reconstructed within 1mm of their nominal location. An accurate co-registration between the BrachyView and TRUS coordinate system was established. The BrachyView system has shown its ability to reconstruct all implanted LDR seeds within a tissue equivalent prostate gel phantom, providing both anatomical and seed position information in a single interface. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  7. How to Seek EPA Approval for Pesticide Applicator Soil Fumigation Exams

    EPA Pesticide Factsheets

    Registrants of soil fumigant products offer EPA-approved training for certified pesticide applicators. Although not required, state lead agencies (SLAs) may seek EPA’s approval and provide applicators with an alternative to registrant-sponsored training.

  8. 32 CFR 1288.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... for the registration, inspection, and marking of privately owned vehicles (POV) on Defense Logistics... Defense Logistics Agency, and to all other individuals subject to motor vehicle registration requirements...

  9. 32 CFR 1288.1 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... for the registration, inspection, and marking of privately owned vehicles (POV) on Defense Logistics... Defense Logistics Agency, and to all other individuals subject to motor vehicle registration requirements...

  10. 32 CFR 1288.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... for the registration, inspection, and marking of privately owned vehicles (POV) on Defense Logistics... Defense Logistics Agency, and to all other individuals subject to motor vehicle registration requirements...

  11. 32 CFR 1288.1 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... for the registration, inspection, and marking of privately owned vehicles (POV) on Defense Logistics... Defense Logistics Agency, and to all other individuals subject to motor vehicle registration requirements...

  12. 32 CFR 1288.1 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS... for the registration, inspection, and marking of privately owned vehicles (POV) on Defense Logistics... Defense Logistics Agency, and to all other individuals subject to motor vehicle registration requirements...

  13. 14 CFR 47.1 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION General § 47.1 Applicability. This part prescribes the requirements for registering aircraft under... Aircraft Registration. Subpart C applies to each applicant for and holder of, a Dealers' Aircraft...

  14. Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data.

    PubMed

    Tektonidis, Marco; Kim, Il-Han; Chen, Yi-Chun M; Eils, Roland; Spector, David L; Rohr, Karl

    2015-01-01

    The analysis of the motion of subcellular particles in live cell microscopy images is essential for understanding biological processes within cells. For accurate quantification of the particle motion, compensation of the motion and deformation of the cell nucleus is required. We introduce a non-rigid multi-frame registration approach for live cell fluorescence microscopy image data. Compared to existing approaches using pairwise registration, our approach exploits information from multiple consecutive images simultaneously to improve the registration accuracy. We present three intensity-based variants of the multi-frame registration approach and we investigate two different temporal weighting schemes. The approach has been successfully applied to synthetic and live cell microscopy image sequences, and an experimental comparison with non-rigid pairwise registration has been carried out. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Microfluidic hubs, systems, and methods for interface fluidic modules

    DOEpatents

    Bartsch, Michael S; Claudnic, Mark R; Kim, Hanyoup; Patel, Kamlesh D; Renzi, Ronald F; Van De Vreugde, James L

    2015-01-27

    Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.

  16. Comparison of manual and automatic MR‐CT registration for radiotherapy of prostate cancer

    PubMed Central

    Carl, Jesper; Østergaard, Lasse Riis

    2016-01-01

    In image‐guided radiotherapy (IGRT) of prostate cancer, delineation of the clinical target volume (CTV) often relies on magnetic resonance (MR) because of its good soft‐tissue visualization. Registration of MR and computed tomography (CT) is required in order to add this accurate delineation to the dose planning CT. An automatic approach for local MR‐CT registration of the prostate has previously been developed using a voxel property‐based registration as an alternative to a manual landmark‐based registration. The aim of this study is to compare the two registration approaches and to investigate the clinical potential for replacing the manual registration with the automatic registration. Registrations and analysis were performed for 30 prostate cancer patients treated with IGRT using a Ni‐Ti prostate stent as a fiducial marker. The comparison included computing translational and rotational differences between the approaches, visual inspection, and computing the overlap of the CTV. The computed mean translational difference was 1.65, 1.60, and 1.80 mm and the computed mean rotational difference was 1.51°, 3.93°, and 2.09° in the superior/inferior, anterior/posterior, and medial/lateral direction, respectively. The sensitivity of overlap was 87%. The results demonstrate that the automatic registration approach performs registrations comparable to the manual registration. PACS number(s): 87.57.nj, 87.61.‐c, 87.57.Q‐, 87.56.J‐ PMID:27167285

  17. Introduction to Remote Sensing Image Registration

    NASA Technical Reports Server (NTRS)

    Le Moigne, Jacqueline

    2017-01-01

    For many applications, accurate and fast image registration of large amounts of multi-source data is the first necessary step before subsequent processing and integration. Image registration is defined by several steps and each step can be approached by various methods which all present diverse advantages and drawbacks depending on the type of data, the type of applications, the a prior information known about the data and the type of accuracy that is required. This paper will first present a general overview of remote sensing image registration and then will go over a few specific methods and their applications

  18. Impact of regulatory requirements on medicine registration in African countries – perceptions and experiences of pharmaceutical companies in South Africa

    PubMed Central

    Narsai, Kirti; Williams, Abeda; Mantel-Teeuwisse, Aukje Kaija

    2012-01-01

    Objective: Access to medicines has long been and remains a challenge in African countries. The impact of medicines registration policies in these countries poses a challenge for pharmaceutical companies wanting to register medicines in these countries. The recent AMRHI (African Medicines Registration Harmonisation Initiative) has increased the focus on the need for harmonisation. Medicines registration regulations differ across African countries. Anecdotal evidence, based on the experience of pharmaceutical companies on progress towards harmonisation is somewhat different, i.e. that country specific requirements were a barrier to the registration of medicines. The objective of this study was therefore to determine the nature and extent of regulatory hurdles experienced by pharmaceutical companies who wish to register and supply medicines to African countries. Methods: This cross-sectional descriptive pilot study was conducted across pharmaceutical companies, both local and multinational. These companies were based in South Africa and were also members of Pharmaceutical Industry Association of South Africa (PIASA). The pharmaceutical companies supply both the private and public sectors. An online survey was developed using Survey Monkey. Survey questions focused on the following strands: nature and level of current supply of medicines to African countries by companies, general regulatory requirements, region specific questions and country specific questions across four regional economic communities in Africa, namely; Southern African Development Community (SADC), East African Community (EAC), Economic Community of the West African States (ECOWAS) and Economic Community of Central African States (ECCAS). Results: A total of 33 responses were received to the questionnaire of which 26 respondents were from the PIASA Regulatory working group and 7 were from the PIASA Export working group.It was noted that since most of the regulatory authorities in Africa are resource-constrained, harmonisation of medicine registration policies will contribute positively to ensuring the safety, quality and efficacy of medicines. The experience of pharmaceutical companies indicated that country specific regulatory requirements are a barrier to registering and supplying medicines to African countries. In particular, GMP inspections, GMP inspection fees and country specific labeling were cited as key problems. Conclusion: Pharmaceutical companies operating in African markets are experiencing difficulties in complying with the technical requirements of individual African countries. Further research is required to provide a balanced perspective on the country specific regulatory requirements vs. the African Regulatory Harmonisation Initiative (AMRHI). PMID:23093897

  19. 40 CFR 80.1452 - What are the requirements related to the EPA Moderated Transaction System (EMTS)?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... importer. (2) The EPA company registration number of the renewable fuel or foreign ethanol producer, as... registration number of the renewable fuel or foreign ethanol producer, as applicable. (5) The importer's EPA...

  20. 24 CFR 1710.3 - General applicability.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false General applicability. 1710.3 Section 1710.3 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION General Requirements...

  1. 18 CFR 807.3 - Administrative agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... agreements. 807.3 Section 807.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION WATER WITHDRAWAL REGISTRATION § 807.3 Administrative agreements. The Commission may complete appropriate administrative agreements or arrangements to carry out this registration requirement through the offices of...

  2. 18 CFR 807.3 - Administrative agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... agreements. 807.3 Section 807.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION WATER WITHDRAWAL REGISTRATION § 807.3 Administrative agreements. The Commission may complete appropriate administrative agreements or arrangements to carry out this registration requirement through the offices of...

  3. 18 CFR 807.3 - Administrative agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... agreements. 807.3 Section 807.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION WATER WITHDRAWAL REGISTRATION § 807.3 Administrative agreements. The Commission may complete appropriate administrative agreements or arrangements to carry out this registration requirement through the offices of...

  4. 18 CFR 807.3 - Administrative agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... agreements. 807.3 Section 807.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION WATER WITHDRAWAL REGISTRATION § 807.3 Administrative agreements. The Commission may complete appropriate administrative agreements or arrangements to carry out this registration requirement through the offices of...

  5. 24 CFR 1710.116 - Additional information.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Additional information. 1710.116 Section 1710.116 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  6. 24 CFR 1710.116 - Additional information.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Additional information. 1710.116 Section 1710.116 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  7. 24 CFR 1710.116 - Additional information.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Additional information. 1710.116 Section 1710.116 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  8. 24 CFR 1710.116 - Additional information.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Additional information. 1710.116 Section 1710.116 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  9. The Importance of Soil Protein Fate to PIP Crop Registration

    EPA Science Inventory

    Plant Incorporated Protectant (PIP) crops are registered under the authority of the Federal Insecticide Fungicide and Rodenticide Act (FIFRA) and as part of this registration certain environmental fate information is required to properly judge the environmental compatibility of n...

  10. 47 CFR 17.5 - Commission consideration of applications for station authorization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... station authorization. 17.5 Section 17.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL... of applications for station authorization. (a) Applications for station authorization, excluding... required, the registrant must supply the structure's registration number upon request by the Commission. (c...

  11. 47 CFR 17.5 - Commission consideration of applications for station authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... station authorization. 17.5 Section 17.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL... of applications for station authorization. (a) Applications for station authorization, excluding... required, the registrant must supply the structure's registration number upon request by the Commission. (c...

  12. 47 CFR 17.5 - Commission consideration of applications for station authorization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... station authorization. 17.5 Section 17.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL... of applications for station authorization. (a) Applications for station authorization, excluding... required, the registrant must supply the structure's registration number upon request by the Commission. (c...

  13. 47 CFR 17.5 - Commission consideration of applications for station authorization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... station authorization. 17.5 Section 17.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL... of applications for station authorization. (a) Applications for station authorization, excluding... required, the registrant must supply the structure's registration number upon request by the Commission. (c...

  14. 47 CFR 17.5 - Commission consideration of applications for station authorization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... station authorization. 17.5 Section 17.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL... of applications for station authorization. (a) Applications for station authorization, excluding... required, the registrant must supply the structure's registration number upon request by the Commission. (c...

  15. PRN 83-3: Label Improvement Program - Storage and Disposal Label Statements

    EPA Pesticide Factsheets

    This Notice is to inform all registrants that the label of all pesticide products must include updated storage and disposal statements. No application for amended registration is required if you use the exact wording contained in this Notice.

  16. 14 CFR 45.1 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... and registration marking of U.S. registered aircraft. [Doc. No. 2047, 29 FR 3223, Mar. 11, 1964, as... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT IDENTIFICATION AND REGISTRATION MARKING General § 45.1 Applicability. This part prescribes the requirements for— (a...

  17. 14 CFR 45.1 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and registration marking of U.S. registered aircraft. [Doc. No. 2047, 29 FR 3223, Mar. 11, 1964, as... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT IDENTIFICATION AND REGISTRATION MARKING General § 45.1 Applicability. This part prescribes the requirements for— (a...

  18. 14 CFR 45.1 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and registration marking of U.S. registered aircraft. [Doc. No. 2047, 29 FR 3223, Mar. 11, 1964, as... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT IDENTIFICATION AND REGISTRATION MARKING General § 45.1 Applicability. This part prescribes the requirements for— (a...

  19. Gaussian Process Interpolation for Uncertainty Estimation in Image Registration

    PubMed Central

    Wachinger, Christian; Golland, Polina; Reuter, Martin; Wells, William

    2014-01-01

    Intensity-based image registration requires resampling images on a common grid to evaluate the similarity function. The uncertainty of interpolation varies across the image, depending on the location of resampled points relative to the base grid. We propose to perform Bayesian inference with Gaussian processes, where the covariance matrix of the Gaussian process posterior distribution estimates the uncertainty in interpolation. The Gaussian process replaces a single image with a distribution over images that we integrate into a generative model for registration. Marginalization over resampled images leads to a new similarity measure that includes the uncertainty of the interpolation. We demonstrate that our approach increases the registration accuracy and propose an efficient approximation scheme that enables seamless integration with existing registration methods. PMID:25333127

  20. 3D surface-based registration of ultrasound and histology in prostate cancer imaging.

    PubMed

    Schalk, Stefan G; Postema, Arnoud; Saidov, Tamerlan A; Demi, Libertario; Smeenge, Martijn; de la Rosette, Jean J M C H; Wijkstra, Hessel; Mischi, Massimo

    2016-01-01

    Several transrectal ultrasound (TRUS)-based techniques aiming at accurate localization of prostate cancer are emerging to improve diagnostics or to assist with focal therapy. However, precise validation prior to introduction into clinical practice is required. Histopathology after radical prostatectomy provides an excellent ground truth, but needs accurate registration with imaging. In this work, a 3D, surface-based, elastic registration method was developed to fuse TRUS images with histopathologic results. To maximize the applicability in clinical practice, no auxiliary sensors or dedicated hardware were used for the registration. The mean registration errors, measured in vitro and in vivo, were 1.5±0.2 and 2.1±0.5mm, respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. [Bioequivalence of dermatological topical medicines:the Brazilian scenario and the challenges for health surveillance].

    PubMed

    Soares, Kelen Carine Costa; Moraes, Marcelo Vogler; Gelfuso, Guilherme Martins; Gratieri, Taís

    2015-11-01

    The comparative evaluation required for the registration of generic topical medicines in Brazil is conducted by means of a pharmaceutical equivalence study, which merely assesses the physical/chemical and microbiological parameters of the formulations. At the international level, clinical or pharmacodynamic studies are now being required to prove the efficacy and safety of semisolid topical generic formulations. This work presents a comparison of the different requirements for the registration of topical formulations, taking into consideration the various regulatory authorities, and presents a survey of topical medicines registered in Brazil prior to 2013. The survey revealed that in comparison with the USA there were many more copies of these formulations registered in Brazil. This fact, together with the large number of studies in the literature showing the lack of bioequivalence of topical medication, is clear proof of the major importance of the need to realign Brazilian legislation with respect to the technical requirements for the registration of generic and similar medication for dermatological topical application in Brazil.

  2. Automated replication of cone beam CT-guided treatments in the Pinnacle(3) treatment planning system for adaptive radiotherapy.

    PubMed

    Hargrave, Catriona; Mason, Nicole; Guidi, Robyn; Miller, Julie-Anne; Becker, Jillian; Moores, Matthew; Mengersen, Kerrie; Poulsen, Michael; Harden, Fiona

    2016-03-01

    Time-consuming manual methods have been required to register cone-beam computed tomography (CBCT) images with plans in the Pinnacle(3) treatment planning system in order to replicate delivered treatments for adaptive radiotherapy. These methods rely on fiducial marker (FM) placement during CBCT acquisition or the image mid-point to localise the image isocentre. A quality assurance study was conducted to validate an automated CBCT-plan registration method utilising the Digital Imaging and Communications in Medicine (DICOM) Structure Set (RS) and Spatial Registration (RE) files created during online image-guided radiotherapy (IGRT). CBCTs of a phantom were acquired with FMs and predetermined setup errors using various online IGRT workflows. The CBCTs, DICOM RS and RE files were imported into Pinnacle(3) plans of the phantom and the resulting automated CBCT-plan registrations were compared to existing manual methods. A clinical protocol for the automated method was subsequently developed and tested retrospectively using CBCTs and plans for six bladder patients. The automated CBCT-plan registration method was successfully applied to thirty-four phantom CBCT images acquired with an online 0 mm action level workflow. Ten CBCTs acquired with other IGRT workflows required manual workarounds. This was addressed during the development and testing of the clinical protocol using twenty-eight patient CBCTs. The automated CBCT-plan registrations were instantaneous, replicating delivered treatments in Pinnacle(3) with errors of ±0.5 mm. These errors were comparable to mid-point-dependant manual registrations but superior to FM-dependant manual registrations. The automated CBCT-plan registration method quickly and reliably replicates delivered treatments in Pinnacle(3) for adaptive radiotherapy.

  3. Using manual prostate contours to enhance deformable registration of endorectal MRI.

    PubMed

    Cheung, M R; Krishnan, K

    2012-10-01

    Endorectal MRI provides detailed images of the prostate anatomy and is useful for radiation treatment planning. Here we describe a Demons field-initialized B-spline deformable registration of prostate MRI. T2-weighted endorectal MRIs of five patients were used. The prostate and the tumor of each patient were manually contoured. The planning MRIs and their segmentations were simulated by warping the corresponding endorectal MRIs using thin plate spline (TPS). Deformable registration was initialized using the deformation field generated using Demons algorithm to map the deformed prostate MRI to the non-deformed one. The solution was refined with B-Spline registration. Volume overlap similarity was used to assess the accuracy of registration and to suggest a minimum margin to account for the registration errors. Initialization using Demons algorithm took about 15 min on a computer with 2.8 GHz Intel, 1.3 GB RAM. Refinement B-spline registration (200 iterations) took less than 5 min. Using the synthetic images as the ground truth, at zero margin, the average (S.D.) 98 (±0.4)% for prostate coverage was 97 (±1)% for tumor. The average (±S.D.) treatment margin required to cover the entire prostate was 1.5 (±0.2)mm. The average (± S.D.) treatment margin required to cover the tumor was 0.7 (±0.1)mm. We also demonstrated the challenges in registering an in vivo deformed MRI to an in vivo non-deformed MRI. We here present a deformable registration scheme that can overcome large deformation. This platform is expected to be useful for prostate cancer radiation treatment planning. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  4. A Parallel Nonrigid Registration Algorithm Based on B-Spline for Medical Images.

    PubMed

    Du, Xiaogang; Dang, Jianwu; Wang, Yangping; Wang, Song; Lei, Tao

    2016-01-01

    The nonrigid registration algorithm based on B-spline Free-Form Deformation (FFD) plays a key role and is widely applied in medical image processing due to the good flexibility and robustness. However, it requires a tremendous amount of computing time to obtain more accurate registration results especially for a large amount of medical image data. To address the issue, a parallel nonrigid registration algorithm based on B-spline is proposed in this paper. First, the Logarithm Squared Difference (LSD) is considered as the similarity metric in the B-spline registration algorithm to improve registration precision. After that, we create a parallel computing strategy and lookup tables (LUTs) to reduce the complexity of the B-spline registration algorithm. As a result, the computing time of three time-consuming steps including B-splines interpolation, LSD computation, and the analytic gradient computation of LSD, is efficiently reduced, for the B-spline registration algorithm employs the Nonlinear Conjugate Gradient (NCG) optimization method. Experimental results of registration quality and execution efficiency on the large amount of medical images show that our algorithm achieves a better registration accuracy in terms of the differences between the best deformation fields and ground truth and a speedup of 17 times over the single-threaded CPU implementation due to the powerful parallel computing ability of Graphics Processing Unit (GPU).

  5. Study time within pre-registration nurse education: A critical review of the literature.

    PubMed

    Barker, Caroline; King, Nigel; Snowden, Michael; Ousey, Karen

    2016-06-01

    Pre-registration nursing students throughout the United Kingdom (UK) are required to complete a minimum number of theory hours within the course. Anecdotal evidence suggests that students are required to attend campus for approximately fifty percent of the theory hours. The remaining theory hours are often labelled as 'study time' in which students are not required to attend campus. There is a general assumption amongst many academics that all students are prepared and motivated to direct their learning and therefore use this time to study. However some students chose to work during this time and many have dependents. Considering the increasing cost of nurse education combined with the government cuts to student bursaries in England it is timely to review the literature to determine how study time is used within pre-registration nurse education. To present a critical review of the literature pertaining to study time in pre-registration nurse education. An integrative review of the literature. A search of electronic databases: Cumulative Index to Nursing and Allied Health (CINAHL); Cochrane; Medline; Science Direct; Blackwell Synergy; Electronic Journals Service (EJS); Scopus; Taylor & Francis, Eric and Routledge Wiley was undertaken. The inclusion criteria consisted of peer reviewed primary research, discussion papers, unpublished doctoral theses' and editorial papers directly related to the key words and nurse education published in English. Twelve papers were included in the review. Analysis of the papers led to the development of two themes: orientation to self-directed learning (SDL) and preparation for SDL. The literature demonstrates that pre-registration nursing students lack the necessary skills for SDL. There is a lack of research on how study time is used within pre-registration nurse education. This calls for empirical research to fully explore how nursing students and lecturers perceive study time within pre-registration nursing curricula. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  6. 49 CFR 604.25 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... TRANSPORTATION CHARTER SERVICE Complaints § 604.25 Purpose. This subpart describes the requirements for filing a complaint challenging the registration of a private charter operator or qualified human service organization on the FTA charter registration Web site and filing a complaint regarding the provision of charter...

  7. 29 CFR 29.13 - Recognition of State Apprenticeship Agencies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... its authority to grant recognition to a State Apprenticeship Agency. Recognition confers non-exclusive... carry out the functions of a Registration Agency, including: Outreach and education; registration of... the areas of non-conformity, require corrective action, and offer technical assistance. After the...

  8. 76 FR 46293 - Information Collections Being Submitted for Review and Approval to the Office of Management and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ...-0139. Title: Application for Antenna Structure Registration. Form No.: FCC Form 854. Type of Review... registration number at base of antenna structure. Frequency of Response: On occasion reporting requirement... a reasonable possibility [[Page 46294

  9. Medicine Handbook.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Office of the Professions.

    New York State education law, rules, and regulations concerning the practice of medicine are presented, along with requirements and procedures for obtaining licensure and first registration as a physician. State statutory provisions cover: duration and registration of a license, practice and regulation of the profession, supervision by the Board…

  10. 47 CFR 87.107 - Station identification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... aircraft followed by the characters of the registration marking (“N” number) of the aircraft, omitting the... type of aircraft followed by the last three characters of the registration marking. Notwithstanding any... Operating Requirements and Procedures Operating Procedures § 87.107 Station identification. (a) Aircraft...

  11. 47 CFR 87.107 - Station identification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... aircraft followed by the characters of the registration marking (“N” number) of the aircraft, omitting the... type of aircraft followed by the last three characters of the registration marking. Notwithstanding any... Operating Requirements and Procedures Operating Procedures § 87.107 Station identification. (a) Aircraft...

  12. 47 CFR 87.107 - Station identification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... aircraft followed by the characters of the registration marking (“N” number) of the aircraft, omitting the... type of aircraft followed by the last three characters of the registration marking. Notwithstanding any... Operating Requirements and Procedures Operating Procedures § 87.107 Station identification. (a) Aircraft...

  13. 47 CFR 87.107 - Station identification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... aircraft followed by the characters of the registration marking (“N” number) of the aircraft, omitting the... type of aircraft followed by the last three characters of the registration marking. Notwithstanding any... Operating Requirements and Procedures Operating Procedures § 87.107 Station identification. (a) Aircraft...

  14. 47 CFR 87.107 - Station identification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... aircraft followed by the characters of the registration marking (“N” number) of the aircraft, omitting the... type of aircraft followed by the last three characters of the registration marking. Notwithstanding any... Operating Requirements and Procedures Operating Procedures § 87.107 Station identification. (a) Aircraft...

  15. [Development of an ophthalmological clinical information system for inpatient eye clinics].

    PubMed

    Kortüm, K U; Müller, M; Babenko, A; Kampik, A; Kreutzer, T C

    2015-12-01

    In times of increased digitalization in healthcare, departments of ophthalmology are faced with the challenge of introducing electronic clinical health records (EHR); however, specialized software for ophthalmology is not available with most major EHR sytems. The aim of this project was to create specific ophthalmological user interfaces for large inpatient eye care providers within a hospitalwide EHR. Additionally the integration of ophthalmic imaging systems, scheduling and surgical documentation should be achieved. The existing EHR i.s.h.med (Siemens, Germany) was modified using advanced business application programming (ABAP) language to create specific ophthalmological user interfaces for reproduction and moreover optimization of the clinical workflow. A user interface for documentation of ambulatory patients with eight tabs was designed. From June 2013 to October 2014 a total of 61,551 patient contact details were documented. For surgical documentation a separate user interface was set up. Digital clinical orders for documentation of registration and scheduling of operations user interfaces were also set up. A direct integration of ophthalmic imaging modalities could be established. An ophthalmologist-orientated EHR for outpatient and surgical documentation for inpatient clinics was created and successfully implemented. By incorporation of imaging procedures the foundation of future smart/big data analyses was created.

  16. A study on the theoretical and practical accuracy of conoscopic holography-based surface measurements: toward image registration in minimally invasive surgery†

    PubMed Central

    Burgner, J.; Simpson, A. L.; Fitzpatrick, J. M.; Lathrop, R. A.; Herrell, S. D.; Miga, M. I.; Webster, R. J.

    2013-01-01

    Background Registered medical images can assist with surgical navigation and enable image-guided therapy delivery. In soft tissues, surface-based registration is often used and can be facilitated by laser surface scanning. Tracked conoscopic holography (which provides distance measurements) has been recently proposed as a minimally invasive way to obtain surface scans. Moving this technique from concept to clinical use requires a rigorous accuracy evaluation, which is the purpose of our paper. Methods We adapt recent non-homogeneous and anisotropic point-based registration results to provide a theoretical framework for predicting the accuracy of tracked distance measurement systems. Experiments are conducted a complex objects of defined geometry, an anthropomorphic kidney phantom and a human cadaver kidney. Results Experiments agree with model predictions, producing point RMS errors consistently < 1 mm, surface-based registration with mean closest point error < 1 mm in the phantom and a RMS target registration error of 0.8 mm in the human cadaver kidney. Conclusions Tracked conoscopic holography is clinically viable; it enables minimally invasive surface scan accuracy comparable to current clinical methods that require open surgery. PMID:22761086

  17. Nencki Genomics Database--Ensembl funcgen enhanced with intersections, user data and genome-wide TFBS motifs.

    PubMed

    Krystkowiak, Izabella; Lenart, Jakub; Debski, Konrad; Kuterba, Piotr; Petas, Michal; Kaminska, Bozena; Dabrowski, Michal

    2013-01-01

    We present the Nencki Genomics Database, which extends the functionality of Ensembl Regulatory Build (funcgen) for the three species: human, mouse and rat. The key enhancements over Ensembl funcgen include the following: (i) a user can add private data, analyze them alongside the public data and manage access rights; (ii) inside the database, we provide efficient procedures for computing intersections between regulatory features and for mapping them to the genes. To Ensembl funcgen-derived data, which include data from ENCODE, we add information on conserved non-coding (putative regulatory) sequences, and on genome-wide occurrence of transcription factor binding site motifs from the current versions of two major motif libraries, namely, Jaspar and Transfac. The intersections and mapping to the genes are pre-computed for the public data, and the result of any procedure run on the data added by the users is stored back into the database, thus incrementally increasing the body of pre-computed data. As the Ensembl funcgen schema for the rat is currently not populated, our database is the first database of regulatory features for this frequently used laboratory animal. The database is accessible without registration using the mysql client: mysql -h database.nencki-genomics.org -u public. Registration is required only to add or access private data. A WSDL webservice provides access to the database from any SOAP client, including the Taverna Workbench with a graphical user interface.

  18. Nencki Genomics Database—Ensembl funcgen enhanced with intersections, user data and genome-wide TFBS motifs

    PubMed Central

    Krystkowiak, Izabella; Lenart, Jakub; Debski, Konrad; Kuterba, Piotr; Petas, Michal; Kaminska, Bozena; Dabrowski, Michal

    2013-01-01

    We present the Nencki Genomics Database, which extends the functionality of Ensembl Regulatory Build (funcgen) for the three species: human, mouse and rat. The key enhancements over Ensembl funcgen include the following: (i) a user can add private data, analyze them alongside the public data and manage access rights; (ii) inside the database, we provide efficient procedures for computing intersections between regulatory features and for mapping them to the genes. To Ensembl funcgen-derived data, which include data from ENCODE, we add information on conserved non-coding (putative regulatory) sequences, and on genome-wide occurrence of transcription factor binding site motifs from the current versions of two major motif libraries, namely, Jaspar and Transfac. The intersections and mapping to the genes are pre-computed for the public data, and the result of any procedure run on the data added by the users is stored back into the database, thus incrementally increasing the body of pre-computed data. As the Ensembl funcgen schema for the rat is currently not populated, our database is the first database of regulatory features for this frequently used laboratory animal. The database is accessible without registration using the mysql client: mysql –h database.nencki-genomics.org –u public. Registration is required only to add or access private data. A WSDL webservice provides access to the database from any SOAP client, including the Taverna Workbench with a graphical user interface. Database URL: http://www.nencki-genomics.org. PMID:24089456

  19. 78 FR 29333 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ...: DPMO Family Update Registration; Family Update Registration Form; OMB Control Number 0704- TBD. Needs and Uses: The information collection requirement is necessary to provide information to family members... form is optional and used to keep an accurate record of family members who attend family updates...

  20. 76 FR 66119 - Agency Information Collection Activities; Revision of a Currently-Approved Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... Request: Application for Certificate of Registration for Foreign Motor Carriers and Foreign Motor Private... Certificate of Registration for Foreign Motor Carriers and Foreign Motor Private Carriers,'' that requires... of Information Technology, IT Operations Division, Department of Transportation, Federal Motor...

  1. 78 FR 77554 - Reports, Forms and Record Keeping Requirements; Agency Information Collection Activity Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... information described is the ``Consolidated Child Restraint System Registration, Labeling and Defect...: National Highway Traffic Safety Administration Title: Consolidated Child Restraint System Registration... the Federal motor vehicle safety standard for child restraint systems (CRSs) to expand its...

  2. 24 CFR 1710.209 - Title and land use.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Title and land use. 1710.209 Section 1710.209 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  3. 24 CFR 1710.107 - Risks of buying land.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Risks of buying land. 1710.107 Section 1710.107 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  4. 24 CFR 1710.209 - Title and land use.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Title and land use. 1710.209 Section 1710.209 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  5. 24 CFR 1710.107 - Risks of buying land.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Risks of buying land. 1710.107 Section 1710.107 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  6. 24 CFR 1710.107 - Risks of buying land.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Risks of buying land. 1710.107 Section 1710.107 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  7. 24 CFR 1710.209 - Title and land use.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Title and land use. 1710.209 Section 1710.209 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  8. 24 CFR 1710.209 - Title and land use.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Title and land use. 1710.209 Section 1710.209 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements...

  9. 47 CFR 64.623 - Administrator requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... administrator of the TRS User Registration Database, the administrator of the VRS Access Technology Reference... parties with a vested interest in the outcome of TRS-related numbering administration and activities. (4) None of the administrator of the TRS User Registration Database, the administrator of the VRS Access...

  10. 47 CFR 64.623 - Administrator requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... administrator of the TRS User Registration Database, the administrator of the VRS Access Technology Reference... parties with a vested interest in the outcome of TRS-related numbering administration and activities. (4) None of the administrator of the TRS User Registration Database, the administrator of the VRS Access...

  11. Research Issues in Image Registration for Remote Sensing

    NASA Technical Reports Server (NTRS)

    Eastman, Roger D.; LeMoigne, Jacqueline; Netanyahu, Nathan S.

    2007-01-01

    Image registration is an important element in data processing for remote sensing with many applications and a wide range of solutions. Despite considerable investigation the field has not settled on a definitive solution for most applications and a number of questions remain open. This article looks at selected research issues by surveying the experience of operational satellite teams, application-specific requirements for Earth science, and our experiments in the evaluation of image registration algorithms with emphasis on the comparison of algorithms for subpixel accuracy. We conclude that remote sensing applications put particular demands on image registration algorithms to take into account domain-specific knowledge of geometric transformations and image content.

  12. Future of Land Remote Sensing: What is Needed

    NASA Technical Reports Server (NTRS)

    Goward, Samuel N.

    2007-01-01

    A viewgraph presentation describing the future of land remote sensing and the new technologies needed for clear views of the Earth is shown. The contents include: 1) Viewing the Earth; 2) Multi-Imagery; 3) May Missions and Sensors; 4) What is Needed; 5) Things to Think About; 6) Global Land Remote Sensing in Landsat 7 Era; 7) Seasonality; 8) Cloud Contamination; 9) NRC Decadal Study; 10) Atmospheric Attenuation; 11) Geo-Registration; 12) Orthorectification Required; 13) Band Registration with OLI; and 14) Things to Do. A viewgraph presentation describing the future of land remote sensing and the new technologies needed for clear views of the Earth is shown. The contents include: 1) Viewing the Earth; 2) Multi-Imagery; 3) May Missions and Sensors; 4) What is Needed; 5) Things to Think About; 6) Global Land Remote Sensing in Landsat 7 Era; 7) Seasonality; 8) Cloud Contamination; 9) NRC Decadal Study; 10) Atmospheric Attenuation; 11) Geo-Registration; 12) Orthorectification Required; 13) Band Registration with OLI; and 14) Things to Do.

  13. How to engage in a reflective discussion for revalidation.

    PubMed

    Middleton, Lyn; Llewellyn, Denise

    2016-07-20

    Rationale and key points This is the sixth in a series of eight articles providing information about the Nursing and Midwifery Council (NMC) revalidation process. This article focuses on the requirement for nurses and midwives to engage in a reflective discussion with an NMC registrant. The purpose of the reflective discussion is to encourage a culture of sharing information to support professional development and improve practice. » The reflective discussion must be undertaken with an NMC registrant. » The reflective discussion should cover the five written reflective accounts required to renew registration. Reflective activity 'How to' revalidate articles can help to update your practice and provide information about the revalidation process, including how you can engage in a reflective discussion. Reflect on and write a short account of: 1. How engaging in a reflective discussion with an NMC registrant helps you to view a situation from another person's perspective. 2. How you could use this article to educate your colleagues. Subscribers can upload their reflective accounts at: rcni.com/portfolio.

  14. An Iterative Closest Points Algorithm for Registration of 3D Laser Scanner Point Clouds with Geometric Features.

    PubMed

    He, Ying; Liang, Bin; Yang, Jun; Li, Shunzhi; He, Jin

    2017-08-11

    The Iterative Closest Points (ICP) algorithm is the mainstream algorithm used in the process of accurate registration of 3D point cloud data. The algorithm requires a proper initial value and the approximate registration of two point clouds to prevent the algorithm from falling into local extremes, but in the actual point cloud matching process, it is difficult to ensure compliance with this requirement. In this paper, we proposed the ICP algorithm based on point cloud features (GF-ICP). This method uses the geometrical features of the point cloud to be registered, such as curvature, surface normal and point cloud density, to search for the correspondence relationships between two point clouds and introduces the geometric features into the error function to realize the accurate registration of two point clouds. The experimental results showed that the algorithm can improve the convergence speed and the interval of convergence without setting a proper initial value.

  15. An Iterative Closest Points Algorithm for Registration of 3D Laser Scanner Point Clouds with Geometric Features

    PubMed Central

    Liang, Bin; Yang, Jun; Li, Shunzhi; He, Jin

    2017-01-01

    The Iterative Closest Points (ICP) algorithm is the mainstream algorithm used in the process of accurate registration of 3D point cloud data. The algorithm requires a proper initial value and the approximate registration of two point clouds to prevent the algorithm from falling into local extremes, but in the actual point cloud matching process, it is difficult to ensure compliance with this requirement. In this paper, we proposed the ICP algorithm based on point cloud features (GF-ICP). This method uses the geometrical features of the point cloud to be registered, such as curvature, surface normal and point cloud density, to search for the correspondence relationships between two point clouds and introduces the geometric features into the error function to realize the accurate registration of two point clouds. The experimental results showed that the algorithm can improve the convergence speed and the interval of convergence without setting a proper initial value. PMID:28800096

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications. The state of the art in image registration will be presented from an engineering perspective. Translational clinical applications will also be discussed tomore » tie these new registration approaches together with imaging and radiation therapy applications in specific diseases such as cervical and lung cancers. Learning Objectives: To understand developing techniques and algorithms in deformable image registration that are likely to translate into clinical tools in the near future. To understand emerging imaging and radiation therapy clinical applications that require such new registration algorithms. Research supported in part by the National Institutes of Health under award numbers P01CA059827, R01CA166119, and R01CA166703. Disclosures: Phillips Medical systems (Hugo), Roger Koch (Christensen) support, Varian Medical Systems (Brock), licensing agreements from Raysearch (Brock) and Varian (Hugo).; K. Brock, Licensing Agreement - RaySearch Laboratories. Research Funding - Varian Medical Systems; G. Hugo, Research grant from National Institutes of Health, award number R01CA166119.; G. Christensen, Research support from NIH grants CA166119 and CA166703 and a gift from Roger Koch. There are no conflicts of interest.« less

  17. A novel model-based evolutionary algorithm for multi-objective deformable image registration with content mismatch and large deformations: benchmarking efficiency and quality

    NASA Astrophysics Data System (ADS)

    Bouter, Anton; Alderliesten, Tanja; Bosman, Peter A. N.

    2017-02-01

    Taking a multi-objective optimization approach to deformable image registration has recently gained attention, because such an approach removes the requirement of manually tuning the weights of all the involved objectives. Especially for problems that require large complex deformations, this is a non-trivial task. From the resulting Pareto set of solutions one can then much more insightfully select a registration outcome that is most suitable for the problem at hand. To serve as an internal optimization engine, currently used multi-objective algorithms are competent, but rather inefficient. In this paper we largely improve upon this by introducing a multi-objective real-valued adaptation of the recently introduced Gene-pool Optimal Mixing Evolutionary Algorithm (GOMEA) for discrete optimization. In this work, GOMEA is tailored specifically to the problem of deformable image registration to obtain substantially improved efficiency. This improvement is achieved by exploiting a key strength of GOMEA: iteratively improving small parts of solutions, allowing to faster exploit the impact of such updates on the objectives at hand through partial evaluations. We performed experiments on three registration problems. In particular, an artificial problem containing a disappearing structure, a pair of pre- and post-operative breast CT scans, and a pair of breast MRI scans acquired in prone and supine position were considered. Results show that compared to the previously used evolutionary algorithm, GOMEA obtains a speed-up of up to a factor of 1600 on the tested registration problems while achieving registration outcomes of similar quality.

  18. WE-H-202-03: Accounting for Large Geometric Changes During Radiotherapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hugo, G.

    2016-06-15

    Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications. The state of the art in image registration will be presented from an engineering perspective. Translational clinical applications will also be discussed tomore » tie these new registration approaches together with imaging and radiation therapy applications in specific diseases such as cervical and lung cancers. Learning Objectives: To understand developing techniques and algorithms in deformable image registration that are likely to translate into clinical tools in the near future. To understand emerging imaging and radiation therapy clinical applications that require such new registration algorithms. Research supported in part by the National Institutes of Health under award numbers P01CA059827, R01CA166119, and R01CA166703. Disclosures: Phillips Medical systems (Hugo), Roger Koch (Christensen) support, Varian Medical Systems (Brock), licensing agreements from Raysearch (Brock) and Varian (Hugo).; K. Brock, Licensing Agreement - RaySearch Laboratories. Research Funding - Varian Medical Systems; G. Hugo, Research grant from National Institutes of Health, award number R01CA166119.; G. Christensen, Research support from NIH grants CA166119 and CA166703 and a gift from Roger Koch. There are no conflicts of interest.« less

  19. WE-H-202-02: Biomechanical Modeling of Anatomical Response Over the Course of Therapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brock, K.

    2016-06-15

    Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications. The state of the art in image registration will be presented from an engineering perspective. Translational clinical applications will also be discussed tomore » tie these new registration approaches together with imaging and radiation therapy applications in specific diseases such as cervical and lung cancers. Learning Objectives: To understand developing techniques and algorithms in deformable image registration that are likely to translate into clinical tools in the near future. To understand emerging imaging and radiation therapy clinical applications that require such new registration algorithms. Research supported in part by the National Institutes of Health under award numbers P01CA059827, R01CA166119, and R01CA166703. Disclosures: Phillips Medical systems (Hugo), Roger Koch (Christensen) support, Varian Medical Systems (Brock), licensing agreements from Raysearch (Brock) and Varian (Hugo).; K. Brock, Licensing Agreement - RaySearch Laboratories. Research Funding - Varian Medical Systems; G. Hugo, Research grant from National Institutes of Health, award number R01CA166119.; G. Christensen, Research support from NIH grants CA166119 and CA166703 and a gift from Roger Koch. There are no conflicts of interest.« less

  20. WE-H-202-01: Memorial Introduction

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kirby, N.

    2016-06-15

    Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications. The state of the art in image registration will be presented from an engineering perspective. Translational clinical applications will also be discussed tomore » tie these new registration approaches together with imaging and radiation therapy applications in specific diseases such as cervical and lung cancers. Learning Objectives: To understand developing techniques and algorithms in deformable image registration that are likely to translate into clinical tools in the near future. To understand emerging imaging and radiation therapy clinical applications that require such new registration algorithms. Research supported in part by the National Institutes of Health under award numbers P01CA059827, R01CA166119, and R01CA166703. Disclosures: Phillips Medical systems (Hugo), Roger Koch (Christensen) support, Varian Medical Systems (Brock), licensing agreements from Raysearch (Brock) and Varian (Hugo).; K. Brock, Licensing Agreement - RaySearch Laboratories. Research Funding - Varian Medical Systems; G. Hugo, Research grant from National Institutes of Health, award number R01CA166119.; G. Christensen, Research support from NIH grants CA166119 and CA166703 and a gift from Roger Koch. There are no conflicts of interest.« less

  1. Maintenance of the Maxillomandibular Position with Digital Workflow in Oral Rehabilitation: A Technical Note.

    PubMed

    Li, Zhongjie; Xia, Yingfeng; Chen, Kai; Zhao, Hanchi; Liu, Yang

    Prosthodontic oral rehabilitation procedures are time consuming and require efforts to maintain the confirmed maxillomandibular relationship. Several occlusal registrations and impressions are needed, and cross-mounting is performed to transfer the diagnostic wax-up to master working casts. The introduction of a digital workflow protocol reduces steps in the required process, and occlusal registrations with less deformation are used. The outcome is a maintained maxillomandibular position that is accurately and conveniently transferred.

  2. What are the essential competencies required of a midwife at the point of registration?

    PubMed

    Butler, Michelle M; Fraser, Diane M; Murphy, Roger J L

    2008-09-01

    to identify the essential competencies required of a midwife at the point of registration. qualitative, descriptive, extended case study and depth interviews. pre-registration midwifery education in England. 39 qualifying midwives, their assessors, midwives and midwife teachers across six higher education institutions, and 20 experienced midwives at two sites. essential competencies were identified relating to (1) being a safe practitioner; (2) having the right attitude; and (3) being an effective communicator. In order to be a safe practitioner, it was proposed that a midwife must have a reasonable degree of self-sufficiency, use up-to-date knowledge in practice, and have self and professional awareness. It was suggested that having the right attitude involves being motivated, being committed to midwifery and being caring and kind. Participants highlighted the importance of effective communication so that midwives can relate to and work in partnership with women and provide truly informed choice. Essential communication skills include active listening, providing appropriate information and flexibility. the most important requirement at registration is that a midwife is safe and will practise safely. However, this capability to be safe is further mediated by attitudes and communication skills. models of midwifery competence should always include personal attributes and effective communication in addition to the competencies required to be able to practise safely, and there should be an explicit focus in curriculum content, skills training and assessment on attitudes and communication.

  3. Invasive Intraneural Interfaces: Foreign Body Reaction Issues

    PubMed Central

    Lotti, Fiorenza; Ranieri, Federico; Vadalà, Gianluca; Zollo, Loredana; Di Pino, Giovanni

    2017-01-01

    Intraneural interfaces are stimulation/registration devices designed to couple the peripheral nervous system (PNS) with the environment. Over the last years, their use has increased in a wide range of applications, such as the control of a new generation of neural-interfaced prostheses. At present, the success of this technology is limited by an electrical impedance increase, due to an inflammatory response called foreign body reaction (FBR), which leads to the formation of a fibrotic tissue around the interface, eventually causing an inefficient transduction of the electrical signal. Based on recent developments in biomaterials and inflammatory/fibrotic pathologies, we explore and select the biological solutions that might be adopted in the neural interfaces FBR context: modifications of the interface surface, such as organic and synthetic coatings; the use of specific drugs or molecular biology tools to target the microenvironment around the interface; the development of bio-engineered-scaffold to reduce immune response and promote interface-tissue integration. By linking what we believe are the major crucial steps of the FBR process with related solutions, we point out the main issues that future research has to focus on: biocompatibility without losing signal conduction properties, good reproducible in vitro/in vivo models, drugs exhaustion and undesired side effects. The underlined pros and cons of proposed solutions show clearly the importance of a better understanding of all the molecular and cellular pathways involved and the need of a multi-target action based on a bio-engineered combination approach. PMID:28932181

  4. 77 FR 73558 - Sex Offender Registration Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... 3225-AA10 Sex Offender Registration Amendments AGENCY: Court Services and Offender Supervision Agency... information for sex offenders. The proposed rule, if finalized, would permit CSOSA to verify addresses of sex... those sex offenders who are required to register but are not under CSOSA's supervision. DATES: Submit...

  5. 24 CFR 1710.216 - Additional information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements... of any membership agreement or similar document. (b) Price range, type of sales and marketing. (1) State the price range of lots in the subdivision. (2) State the type of sales to be made, i.e., contract...

  6. 41 CFR 101-25.110 - Tire identification/registration program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Tire identification...-General Policies § 101-25.110 Tire identification/registration program. The regulations issued by the Department of Transportation in 49 CFR part 574, Tire Identification and Recordkeeping, require that tire...

  7. 78 FR 3418 - Pesticides; Draft Guidance for Pesticide Registrants on Web-Distributed Labeling for Pesticide...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... with pesticide labeling requirements and thereby protecting human health and the environment from... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2012-0906; FRL-9374-4] Pesticides; Draft Guidance for Pesticide Registrants on Web- Distributed Labeling for Pesticide Products AGENCY: Environmental Protection...

  8. 49 CFR 107.502 - General registration requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... one or more tanks or cargo tanks on a motor vehicle or to a motor vehicle suspension component; (ii... MATERIALS PROGRAM PROCEDURES Registration of Cargo Tank and Cargo Tank Motor Vehicle Manufacturers... the certification of the cargo tank motor vehicle; or (iii) The installation of linings, coatings, or...

  9. 37 CFR 11.7 - Requirements for registration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... registration examination or continuing legal education; or (B) Represented the Office in patent cases before... whole to see if there is a drug or alcohol abuse issue. An individual appearing to abuse drugs or... issues concerning good moral character and reputation when completing the application or any time...

  10. 37 CFR 11.7 - Requirements for registration.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... registration examination or continuing legal education; or (B) Represented the Office in patent cases before... whole to see if there is a drug or alcohol abuse issue. An individual appearing to abuse drugs or... issues concerning good moral character and reputation when completing the application or any time...

  11. 37 CFR 11.7 - Requirements for registration.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... registration examination or continuing legal education; or (B) Represented the Office in patent cases before... whole to see if there is a drug or alcohol abuse issue. An individual appearing to abuse drugs or... issues concerning good moral character and reputation when completing the application or any time...

  12. 17 CFR 230.437a - Written consents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Are filing a registration statement containing financial statements in which Arthur Andersen LLP (or a foreign affiliate of Arthur Andersen LLP) had been acting as the independent public accountant. (b... dispense with the requirement for the registrant to file the written consent of Arthur Andersen LLP (or a...

  13. 42 CFR 493.639 - Fee for revised certificate.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS General Administration § 493.639 Fee for revised certificate. (a) If, after a laboratory is issued a registration certificate, it changes its name or location, the laboratory must pay a fee to cover the cost of issuing a revised registration...

  14. 42 CFR 493.639 - Fee for revised certificate.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS General Administration § 493.639 Fee for revised certificate. (a) If, after a laboratory is issued a registration certificate, it changes its name or location, the laboratory must pay a fee to cover the cost of issuing a revised registration...

  15. Implementing a Web-Based Registration and Administration System for Credit-by-Examination: Graduate Education Course Test Case.

    ERIC Educational Resources Information Center

    Wang, Lih-Ching Chen

    2002-01-01

    Discusses the problems and successes encountered in implementing a Web-based registration and administration system for credit-by-examination in a required graduate course, detailing the ways in which this system improves upon its paper-based predecessor. (EV)

  16. 19 CFR 122.25 - Exemption from special landing requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) and (c)(6) of this section: (1) Aircraft registration number(s) and manufacturer's serial number(s... other (foreign) registration number for the aircraft; (ii) Notify Customs of the sale, theft...; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Private Aircraft § 122.25 Exemption from special landing...

  17. 19 CFR 122.25 - Exemption from special landing requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) and (c)(6) of this section: (1) Aircraft registration number(s) and manufacturer's serial number(s... other (foreign) registration number for the aircraft; (ii) Notify Customs of the sale, theft...; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Private Aircraft § 122.25 Exemption from special landing...

  18. 19 CFR 122.25 - Exemption from special landing requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) and (c)(6) of this section: (1) Aircraft registration number(s) and manufacturer's serial number(s... other (foreign) registration number for the aircraft; (ii) Notify Customs of the sale, theft...; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Private Aircraft § 122.25 Exemption from special landing...

  19. A Parallel Nonrigid Registration Algorithm Based on B-Spline for Medical Images

    PubMed Central

    Wang, Yangping; Wang, Song

    2016-01-01

    The nonrigid registration algorithm based on B-spline Free-Form Deformation (FFD) plays a key role and is widely applied in medical image processing due to the good flexibility and robustness. However, it requires a tremendous amount of computing time to obtain more accurate registration results especially for a large amount of medical image data. To address the issue, a parallel nonrigid registration algorithm based on B-spline is proposed in this paper. First, the Logarithm Squared Difference (LSD) is considered as the similarity metric in the B-spline registration algorithm to improve registration precision. After that, we create a parallel computing strategy and lookup tables (LUTs) to reduce the complexity of the B-spline registration algorithm. As a result, the computing time of three time-consuming steps including B-splines interpolation, LSD computation, and the analytic gradient computation of LSD, is efficiently reduced, for the B-spline registration algorithm employs the Nonlinear Conjugate Gradient (NCG) optimization method. Experimental results of registration quality and execution efficiency on the large amount of medical images show that our algorithm achieves a better registration accuracy in terms of the differences between the best deformation fields and ground truth and a speedup of 17 times over the single-threaded CPU implementation due to the powerful parallel computing ability of Graphics Processing Unit (GPU). PMID:28053653

  20. Registration performance on EUV masks using high-resolution registration metrology

    NASA Astrophysics Data System (ADS)

    Steinert, Steffen; Solowan, Hans-Michael; Park, Jinback; Han, Hakseung; Beyer, Dirk; Scherübl, Thomas

    2016-10-01

    Next-generation lithography based on EUV continues to move forward to high-volume manufacturing. Given the technical challenges and the throughput concerns a hybrid approach with 193 nm immersion lithography is expected, at least in the initial state. Due to the increasing complexity at smaller nodes a multitude of different masks, both DUV (193 nm) and EUV (13.5 nm) reticles, will then be required in the lithography process-flow. The individual registration of each mask and the resulting overlay error are of crucial importance in order to ensure proper functionality of the chips. While registration and overlay metrology on DUV masks has been the standard for decades, this has yet to be demonstrated on EUV masks. Past generations of mask registration tools were not necessarily limited in their tool stability, but in their resolution capabilities. The scope of this work is an image placement investigation of high-end EUV masks together with a registration and resolution performance qualification. For this we employ a new generation registration metrology system embedded in a production environment for full-spec EUV masks. This paper presents excellent registration performance not only on standard overlay markers but also on more sophisticated e-beam calibration patterns.

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