Sample records for interim technical progress

  1. Jet Crackle

    DTIC Science & Technology

    2015-06-23

    DISTRIBUTION/AVAILABILITY STATEMENT DISTRIBUTION A 13. SUPPLEMENTARY NOTES 14. ABSTRACT Fighter jets and other aircraft with high specific thrust engines...interim, memorandum, master’s thesis , progress, quarterly, research, special, group study, etc. 3. DATES COVERED. Indicate the time during which the...State the type of report, such as final, technical, interim, memorandum, master’s thesis , progress, quarterly, research, special, group study, etc

  2. Progress and future direction for the interim safe storage and disposal of Hanford high-level waste

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kinzer, J.E.; Wodrich, D.D.; Bacon, R.F.

    This paper describes the progress made at the largest environmental cleanup program in the United States. Substantial advances in methods to start interim safe storage of Hanford Site high-level wastes, waste characterization to support both safety- and disposal-related information needs, and proceeding with cost-effective disposal by the U.S. Department of Energy (DOE) and its Hanford Site contractors, have been realized. Challenges facing the Tank Waste Remediation System (TWRS) Program, which is charged with the dual and parallel missions of interim safe storage and disposal of the high-level tank waste stored at the Hanford Site, are described. In these times ofmore » budget austerity, implementing an ongoing program that combines technical excellence and cost effectiveness is the near-term challenge. The technical initiatives and progress described in this paper are made more cost effective by DOE`s focus on work force productivity improvement, reduction of overhead costs, and reduction, integration and simplification of DOE regulations and operations requirements to more closely model those used in the private sector.« less

  3. Quantum Manybody Physics with Rydberg Polaritons

    DTIC Science & Technology

    2016-06-22

    report, such as final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED...for public release. Over the course of this grant, we have seen tremendous progress, both theoretically and experimentally , in our control of photonic...shown in multiple stages of construction at left and below, spans three optical tables in two rooms: One for the experimental control system

  4. Parameter identification for nonlinear aerodynamic systems

    NASA Technical Reports Server (NTRS)

    Pearson, Allan E.

    1993-01-01

    This final technical report covers a three and one-half year period preceding February 28, 1993 during which support was provided under NASA Grant NAG-1-1065. Following a general description of the system identification problem and a brief survey of methods to attack it, the basic ideas behind the approach taken in this research effort are presented. The results obtained are described with reference to the published work, including the five semiannual progress reports previously submitted and two interim technical reports.

  5. LINER FOR EXTRUSION BILLET CONTAINERS. Interim Technical Documentary Progress Report, June 5, 1962-September 5, 1962

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spachner, S.A.

    1962-10-31

    A container-sleeve-liner assembly was designed which will provide adequate support for ceramic, ceramic coated metal, or metal liners. The design minimizes mechanical property requirements of liner materials, and permits rapid removal of worn or damaged liners. A high-strength stem was designed and fabricated. Technical literature on high-strength materials was reviewed, and high-strength materials producers were contacted to locate sources and assess applicability of existing materials for refractory metal extrusion liner use. (auth)

  6. Cyberspace, the 7th Joint Function for 21st Century Warfare

    DTIC Science & Technology

    2017-03-31

    such as final, technical, interim, memorandum, master’s thesis, progress, quarterly, research, special, group study, etc . 3. DATE COVERED...procedures, e.g. RD/FRD, PROPIN, ITAR, etc . Include copyright information. 13. SUPPLEMENTARY NOTES. Enter information not included...elsewhere such as: prepared in cooperation with; translation of; report supersedes; old edition number, etc . 14. ABSTRACT. A brief (approximately

  7. SUSTAINABLE ALLOY DESIGN: SEARCHING FOR RARE EARTH ELEMENT ALTERNATIVES THROUGH CRYSTAL ENGINEERING

    DTIC Science & Technology

    2016-02-26

    Property Maps to Guide Materials Design via Statistical Learning Summer Research Group Meeting – Materials by Design Los Alamos National Laboratory, July...Informatics, Rational design , Quantitative correlative spectroscopy and imaging, DFT, In situ high pressure mechanical property measurements, Superalloy...final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED. Indicate the

  8. 78 FR 20503 - Energy Conservation Program: Availability of the Interim Technical Support Document for High...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... Conservation Program: Availability of the Interim Technical Support Document for High-Intensity Discharge Lamps... high-intensity discharge (HID) lamps energy conservation standards in the Federal Register. This... interim analysis for high- intensity discharge lamps energy conservation standards. The notice provided...

  9. Combinational Optimal Stopping Problems

    DTIC Science & Technology

    2016-04-01

    such as final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED...Vinel, A. and P. Krokhmal (2015) Certainty equivalent measures of risk, Annals of Operations Research , DOI:10.1007/s10479-015-1801-0. [3] Chernikov...Operations Research , 50(3):415–423, 2002. [16] I. Ljubi, P. Mutzel, and B. Zey. Stochastic survivable network design problems. Electronic Notes in Discrete

  10. Development of Career Opportunities for Technicians in the Nuclear Medicine Field, Phase I. Interim Report Number 1: Survey of Job Characteristics, Manpower Needs and Training Resources, July 1969.

    ERIC Educational Resources Information Center

    Technical Education Research Center, Cambridge, MA.

    Phase I of a multiphase research program in progress at the Technical Education Research Center, Inc., was conducted to analyze needs and resources in terms of job performance tasks, career opportunities, and training requirements for nuclear medical technicians. Data were gathered through personal interviews with 203 persons, mostly physicians,…

  11. Field Demonstration of Light Obscuration Particle Counting Technologies to Detect Fuel Contaminates

    DTIC Science & Technology

    2016-12-01

    to detect fuel contamiation including particulates and free water 15. SUBJECT TERMS fuel, JP-8, aviation fuel, contamination, free water ...undissolved water , F24 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT none 18. NUMBER OF PAGES 12 19a. NAME OF RESPONSIBLE PERSON Joel...technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED. Indicate the time during

  12. The New Guard: A Service-Equivalent Force

    DTIC Science & Technology

    2012-06-07

    quartermas ter , medical , ordinance and inspector general. The bureaus were designed to be more efficient and deliver cost aving; but. onl y created...2. REPORT TYPE. State the type of report, such as final , technical, interim, memorandum, master’s thesis , progress, quarterly, research ...the report, performing the research , or credited with the content of the report. The form of entry is the last name, first name, middle initial, and

  13. Cellular Mechanisms of Transcranial Direct Current Stimulation

    DTIC Science & Technology

    2016-07-14

    REPORT TYPE. State the type of report, such as final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group ...in fEPSP timing was not resolved. Importantly, grouping across all pathways (e.g. not controlling pathway selectivity), 8 V/m radial positive fields...each signal group during DCS and in control conditions (no electrical stimulation). F) Changes in synaptic strength for each signal group under all

  14. United States Air Force F-35A Operational Basing Environmental Impact Statement. Appendix E: Comments

    DTIC Science & Technology

    2013-09-01

    such as final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED...appear in the report, e.g. 001; AFAPL30480105. 6. AUTHOR(S). Enter name(s) of person(s) responsible for writing the report, performing the research ...negatively impacted by the noise] SAFTY ALL NEW military aircraft designs suffer crashes during their initial development peri~ Bringing the F-35

  15. An Approach for Evaluating the Technical Quality of Interim Assessments

    ERIC Educational Resources Information Center

    Li, Ying; Marion, Scott; Perie, Marianne; Gong, Brian

    2010-01-01

    Increasing numbers of schools and districts have expressed interest in interim assessment systems to prepare for summative assessments and to improve teaching and learning. However, with so many commercial interim assessments available, schools and districts are struggling to determine which interim assessment is most appropriate to their needs.…

  16. United States Air Force F-35A Operational Basing Environmental Impact Statement. Appendix E: Comments

    DTIC Science & Technology

    2013-09-01

    studies such as this one, and other research conducted in most recent decade. Of course, the housing designation ("not compatible with residential...such as final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED...appear in the report, e.g. 001; AFAPL30480105. 6. AUTHOR(S). Enter name(s) of person(s) responsible for writing the report, performing the research

  17. EPA Interim Evaluation of 2016-2017 Milestone Progress in the Chesapeake Bay Watershed

    EPA Pesticide Factsheets

    This page provides the EPA interim evaluations of the 2016-2017 milestones for the Chesapeake Bay TMDL. These interim assessments provide a mid-point check on the progress made on the 2016-2017 milestones, recognizing the achievements made in 2016.

  18. EPA Interim Evaluation of 2012-2013 Milestone Progress in the Chesapeake Bay Watershed

    EPA Pesticide Factsheets

    This page provides the EPA interim evaluations of the 2012-2013 milestones for the Chesapeake Bay TMDL. These interim assessments provide a mid-point check on the progress made on the 2012-2013 milestones, recognizing the achievements made in 2012.

  19. EPA Interim Evaluation of 2014-2015 Milestone Progress in the Chesapeake Bay Watershed

    EPA Pesticide Factsheets

    This page provides the EPA interim evaluations of the 2014-2015 milestones for the Chesapeake Bay TMDL. These interim assessments provide a mid-point check on the progress made on the 2014-2015 milestones, recognizing the achievements made in 2014.

  20. DEVELOPMENT OF IMPROVED FABRICATION METHODS, PROCESS AND TECHNIQUES FOR PRODUCING TYPICAL AIRCRAFT SHAPES FROM BERYLLIUM. Interim Technical Documentary Progress Report for the Period ending October 31, 1962

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jenkins, R.G.; Siergiej, J.M.

    1962-12-28

    In a program to develop a complete manufacturing process for ihe production of beryllium channels, techniques are being sought for drawing to obtain a flnal product meeting specifications more rigorous than are obtainable by direct extrusion. Progress in designing and procuring the special tooling required to draw complex shapes at elevated temperature is described, and the flrst set of draw dies is evaluated with respect to design and quality. Three experimental draw attempts have been made on U-channels, in addition to draw tests on flats. (auth)

  1. United States Air Force F-35A Operational Basing Environmental Impact Statement. Appendix E: Comments

    DTIC Science & Technology

    2013-09-01

    hreatens the well being of our community, whether through noi se and emissions or the risk of accidents from an under- test ed and flawed design . The...such as final, technical, interim, memorandum, master’s thesis, progress, quarterly, research , special, group study, etc. 3. DATES COVERED...appear in the report, e.g. 001; AFAPL30480105. 6. AUTHOR(S). Enter name(s) of person(s) responsible for writing the report, performing the research

  2. Functions and requirements document for interim store solidified high-level and transuranic waste

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith-Fewell, M.A., Westinghouse Hanford

    1996-05-17

    The functions, requirements, interfaces, and architectures contained within the Functions and Requirements (F{ampersand}R) Document are based on the information currently contained within the TWRS Functions and Requirements database. The database also documents the set of technically defensible functions and requirements associated with the solidified waste interim storage mission.The F{ampersand}R Document provides a snapshot in time of the technical baseline for the project. The F{ampersand}R document is the product of functional analysis, requirements allocation and architectural structure definition. The technical baseline described in this document is traceable to the TWRS function 4.2.4.1, Interim Store Solidified Waste, and its related requirements, architecture,more » and interfaces.« less

  3. Progress report on CCIR studies for guaranteeing access to the geostationary satellite orbit

    NASA Astrophysics Data System (ADS)

    Reinhart, E. E.

    Overall responsibility for preparing a report on the technical information necessary for the World Administrative Radio Conference to be held in the spring of 1984 is vested in the Interim Working Party (IWP) 4/1. The various approaches being considered by the IWP 4/1 to guarantee orbital access are described, along with the criteria that the party has proposed for evaluating and comparing the approaches. These approaches include the following: a regional detailed long-term (10-20 years) a priori allotment plan, a periodically revised (3-5 years) regional detailed allotment plan, a regional or subregional allotment plan with guaranteed access, guaranteed access by means of multilateral coordination, and coordination procedures and technical factors that are revised periodically.

  4. Sb-Based Double Heterojunction Bipolar Transistors (DHBTs) With Fmax 650GHz for 340GHz Transmitter

    DTIC Science & Technology

    2008-12-01

    PROPER IDENTIFICATION . NOT TO BE USED FOR INTERIM PROGRESS REPORTS SEE PAGE 2 FOR INTERIM PROGRESS REPORT INSTRUCTIONS MEMORANDUM OF TRANSMITTAL...conduction band lineup . These advantages have led to rapid progress in increasing device bandwidths, allowing competitive RF performance with established

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Balkwill, D.L.; Reeves, R.H.

    The present document is an interim technical report in which we describe the research which has been completed during the seven-month period since the start of the grant. Progress is summarized in two main areas. The first is microbiological characterization of subsurface materials from the Hanford reservation and the Idaho National Engineering Laboratory, and the second is phylogenetic characterization of these microorganisms. The major tools used for phylogenetic characterization are RFLP analysis of PCR derived material and 16S rRNA sequencing. A description of manuscripts ready for publication is also provided. 4 refs. (MHB)

  6. Autonomy Level Specification for Intelligent Autonomous Vehicles

    DTIC Science & Technology

    2003-09-01

    Autonomy Level Specification for Intelligent Autonomous Vehicles : Interim Progress Report Hui-Min Huang, Elena Messina, James Albus...Level Specification for Intelligent Autonomous Vehicles : Interim Progress Report 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  7. Plutonium storage criteria

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chung, D.; Ascanio, X.

    1996-05-01

    The Department of Energy has issued a technical standard for long-term (>50 years) storage and will soon issue a criteria document for interim (<20 years) storage of plutonium materials. The long-term technical standard, {open_quotes}Criteria for Safe Storage of Plutonium Metals and Oxides,{close_quotes} addresses the requirements for storing metals and oxides with greater than 50 wt % plutonium. It calls for a standardized package that meets both off-site transportation requirements, as well as remote handling requirements from future storage facilities. The interim criteria document, {open_quotes}Criteria for Interim Safe Storage of Plutonium-Bearing Solid Materials{close_quotes}, addresses requirements for storing materials with less thanmore » 50 wt% plutonium. The interim criteria document assumes the materials will be stored on existing sites, and existing facilities and equipment will be used for repackaging to improve the margin of safety.« less

  8. 75 FR 13680 - Commutation of Sentence: Technical Change

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... Sentence: Technical Change AGENCY: Bureau of Prisons, Justice. ACTION: Interim rule. SUMMARY: This document makes a minor technical change to the Bureau of Prisons (Bureau) regulations on sentence commutation to.... Commutation of Sentence: Technical Change This document makes a minor technical change to the Bureau...

  9. The Predictive Validity of Interim Assessment Scores Based on the Full-Information Bifactor Model for the Prediction of End-of-Grade Test Performance

    ERIC Educational Resources Information Center

    Immekus, Jason C.; Atitya, Ben

    2016-01-01

    Interim tests are a central component of district-wide assessment systems, yet their technical quality to guide decisions (e.g., instructional) has been repeatedly questioned. In response, the study purpose was to investigate the validity of a series of English Language Arts (ELA) interim assessments in terms of dimensionality and prediction of…

  10. 33 CFR 385.9 - Implementation principles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of the Plan at specific time intervals during implementation. Interim targets to evaluate progress on... accordance with § 385.39. Interim goals and interim targets shall be consistent with each other. (c... ensure that new information resulting from changed or unforeseen circumstances, new scientific and...

  11. 33 CFR 385.9 - Implementation principles.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of the Plan at specific time intervals during implementation. Interim targets to evaluate progress on... accordance with § 385.39. Interim goals and interim targets shall be consistent with each other. (c... ensure that new information resulting from changed or unforeseen circumstances, new scientific and...

  12. 33 CFR 385.9 - Implementation principles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of the Plan at specific time intervals during implementation. Interim targets to evaluate progress on... accordance with § 385.39. Interim goals and interim targets shall be consistent with each other. (c... ensure that new information resulting from changed or unforeseen circumstances, new scientific and...

  13. 33 CFR 385.9 - Implementation principles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of the Plan at specific time intervals during implementation. Interim targets to evaluate progress on... accordance with § 385.39. Interim goals and interim targets shall be consistent with each other. (c... ensure that new information resulting from changed or unforeseen circumstances, new scientific and...

  14. Remediation management of complex sites using an adaptive site management approach.

    PubMed

    Price, John; Spreng, Carl; Hawley, Elisabeth L; Deeb, Rula

    2017-12-15

    Complex sites require a disproportionate amount of resources for environmental remediation and long timeframes to achieve remediation objectives, due to their complex geologic conditions, hydrogeologic conditions, geochemical conditions, contaminant-related conditions, large scale of contamination, and/or non-technical challenges. A recent team of state and federal environmental regulators, federal agency representatives, industry experts, community stakeholders, and academia worked together as an Interstate Technology & Regulatory Council (ITRC) team to compile resources and create new guidance on the remediation management of complex sites. This article summarizes the ITRC team's recommended process for addressing complex sites through an adaptive site management approach. The team provided guidance for site managers and other stakeholders to evaluate site complexities and determine site remediation potential, i.e., whether an adaptive site management approach is warranted. Adaptive site management was described as a comprehensive, flexible approach to iteratively evaluate and adjust the remedial strategy in response to remedy performance. Key aspects of adaptive site management were described, including tools for revising and updating the conceptual site model (CSM), the importance of setting interim objectives to define short-term milestones on the journey to achieving site objectives, establishing a performance model and metrics to evaluate progress towards meeting interim objectives, and comparing actual with predicted progress during scheduled periodic evaluations, and establishing decision criteria for when and how to adapt/modify/revise the remedial strategy in response to remedy performance. Key findings will be published in an ITRC Technical and Regulatory guidance document in 2017 and free training webinars will be conducted. More information is available at www.itrc-web.org. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. 24 CFR 115.209 - Technical assistance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Technical assistance. 115.209... Substantially Equivalent Agencies § 115.209 Technical assistance. (a) The Assistant Secretary, through the FHEO regional office, may provide technical assistance to the interim and certified agencies at any time. The...

  16. Interim Performance Objectives. Progress Report, 3rd Quarter Fiscal Year 1999.

    ERIC Educational Resources Information Center

    Office of Student Financial Assistance (ED), Washington, DC.

    This document contains a progress report on three categories of interim performance objectives outlined by the Office of Student Financial Assistance (OSFA) in winter 1999. These objectives were to: (1) improve customer service; (2) reduce the overall cost of delivering student aid; and (3) transform the OSFA into a performance-based organization.…

  17. 7 CFR 652.4 - Technical service standards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... must approve all new technologies and innovative practices, including interim standards and specifications, prior to a TSP initiating technical services for those technologies and practices. (c) A TSP must...

  18. 75 FR 77721 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-47; Introduction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ...-019 Morgan. Self-Certification (Interim). V Uniform Suspension and 2009-036 Gary. Debarment Requirement (Interim). VI Limitation on Pass-Through 2008-031 Chambers. Charges. VII Technical Amendments....104-1, 5.601, 7.105, and 10.002. Dated: November 24, 2010. Millisa Gary, Acting Director, Acquisition...

  19. 75 FR 77745 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-47; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... Business 2009-019 Morgan. Self-Certification (Interim). V Uniform Suspension and 2009-036 Gary. Debarment Requirement (Interim). VI Limitation on Pass-Through 2008-031 Chambers. Charges. VII Technical Amendments... 10.002. Dated: November 24, 2010. Millisa Gary, Acting Director, Acquisition Policy Division. [FR Doc...

  20. 5 CFR 308.101 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Definitions. In this part: Student is an individual who is enrolled not less than half-time in a high school, trade school, technical or vocational institute, junior college, college, university or other accredited... interim between school years if the interim is not more than 5 months and if such individual shows to the...

  1. 5 CFR 308.101 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Definitions. In this part: Student is an individual who is enrolled not less than half-time in a high school, trade school, technical or vocational institute, junior college, college, university or other accredited... interim between school years if the interim is not more than 5 months and if such individual shows to the...

  2. 5 CFR 308.101 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Definitions. In this part: Student is an individual who is enrolled not less than half-time in a high school, trade school, technical or vocational institute, junior college, college, university or other accredited... interim between school years if the interim is not more than 5 months and if such individual shows to the...

  3. 5 CFR 308.101 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Definitions. In this part: Student is an individual who is enrolled not less than half-time in a high school, trade school, technical or vocational institute, junior college, college, university or other accredited... interim between school years if the interim is not more than 5 months and if such individual shows to the...

  4. Nutrition and Child Growth and Development in Tunisia. Interim Progress Report, (September 1, 1972--February 28, 1973).

    ERIC Educational Resources Information Center

    Young, Harben Boutourline

    This interim report of the Yale Project describes the progress made on the nutrition and growth study of Tunisian children from September 1, 1972 through February 28, 1973. A major part of the report is devoted to the organizational and data collection problems of the longitudinal study, discussed under the following categories: biomedics,…

  5. A Case Study of Technical Assistance to Demonstration Programs for Young Handicapped Children. Part I.

    ERIC Educational Resources Information Center

    Behr, Shirley K.; And Others

    The interim report presents an evaluation of TADS (Technical Assistance Development System) through case studies of TADS technical assistance to the staffs of two demonstration programs for preschool handicapped children and their families. Purposes of the study included obtaining indepth descriptions of the technical assistance process to…

  6. Flammability, Offgassing, and Compatibility Requirements and Test Procedures. Interim NASA Technical Standard

    NASA Technical Reports Server (NTRS)

    2009-01-01

    This Interim Standard establishes requirements for evaluation, testing, and selection of materials that are intended for use in space vehicles, associated Ground Support Equipment (GSE), and facilities used during assembly, test, and flight operations. Included are requirements, criteria, and test methods for evaluating the flammability, offgassing, and compatibility of materials.

  7. 76 FR 8366 - Science Advisory Board Staff Office; Request for Nominations; SAB Environmental Justice Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... Nominations; SAB Environmental Justice Technical Panel AGENCY: Environmental Protection Agency (EPA). ACTION... experts to serve on the SAB Environmental Justice Technical (EJT) Panel. DATES: Nominations should be...) released the Interim Guidance on Considering Environmental Justice During the Development of an Action...

  8. Education and career progression of imaging administrators.

    PubMed

    South-Winter, Carole

    2014-01-01

    The advancement into leadership positions for many administrators began as staff technologists moving up via interim management opportunities. New managers must develop supervisory skills while simultaneously assuming responsibility for the operation of the department. Mobility today is based primarily on a formal educational background. A transferable set of skills must be augmented with higher education. Those in the imaging sciences realize that an administrative position requires business and management acumen as well as technical skills. A shortage of imaging administrators is predicted due to an aging population and the rapid advancement of technology in healthcare. Institutes of higher education need to address and support the curricula and programs needed, which includes the CRA credential, for this growing field.

  9. Publications of the Jet Propulsion Laboratory, January - December 1973. [bibliography

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Five classes of publications are included in this bibliography: (1) Technical Reports in which the information is complete for a specific accomplishment and is intended for a wide audience. (2) Articles from the bimonthly Deep Space Network Progress Report. Each volume's collection of articles presents a periodical survey of current accomplishments by the Deep Space Network. (3) Technical Memorandums, in which the information is complete for a specific accomplishment but is intended for a limited audience to satisfy unique requirements. (4) Articles from the JPL Quarterly Technical Review. Each article summarizes a recent important development, interim or final results, or an advancement in the state of the art in a scientific or engineering endeavor, This publication has been discontinued, and the issues indexed in this bibliography are the last to be published. (5) Articles published in the open literature. The publications are indexed by: (1) author, (2) subject, and (3) publication type and number. A descriptive entry appears under the name of each author of each publication; an abstract is included with the entry for the primary (first-listed) author.

  10. PROJECT W-551 INTERIM PRETREATMENT SYSTEM PRECONCEPTUAL CANDIDATE TECHNOLOGY DESCRIPTIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    MAY TH

    The Office of River Protection (ORP) has authorized a study to recommend and select options for interim pretreatment of tank waste and support Waste Treatment Plant (WTP) low activity waste (LAW) operations prior to startup of all the WTP facilities. The Interim Pretreatment System (IPS) is to be a moderately sized system which separates entrained solids and 137Cs from tank waste for an interim time period while WTP high level waste vitrification and pretreatment facilities are completed. This study's objective is to prepare pre-conceptual technology descriptions that expand the technical detail for selected solid and cesium separation technologies. This revisionmore » includes information on additional feed tanks.« less

  11. Online Monitoring Technical Basis and Analysis Framework for Emergency Diesel Generators - Interim Report for FY 2013

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Binh T. Pham; Nancy J. Lybeck; Vivek Agarwal

    The Light Water Reactor Sustainability program at Idaho National Laboratory is actively conducting research to develop and demonstrate online monitoring capabilities for active components in existing nuclear power plants. Idaho National Laboratory and the Electric Power Research Institute are working jointly to implement a pilot project to apply these capabilities to emergency diesel generators and generator step-up transformers. The Electric Power Research Institute Fleet-Wide Prognostic and Health Management Software Suite will be used to implement monitoring in conjunction with utility partners: Braidwood Generating Station (owned by Exelon Corporation) for emergency diesel generators, and Shearon Harris Nuclear Generating Station (owned bymore » Duke Energy Progress) for generator step-up transformers. This report presents monitoring techniques, fault signatures, and diagnostic and prognostic models for emergency diesel generators. Emergency diesel generators provide backup power to the nuclear power plant, allowing operation of essential equipment such as pumps in the emergency core coolant system during catastrophic events, including loss of offsite power. Technical experts from Braidwood are assisting Idaho National Laboratory and Electric Power Research Institute in identifying critical faults and defining fault signatures associated with each fault. The resulting diagnostic models will be implemented in the Fleet-Wide Prognostic and Health Management Software Suite and tested using data from Braidwood. Parallel research on generator step-up transformers was summarized in an interim report during the fourth quarter of fiscal year 2012.« less

  12. Report: EPA’s Management of Interim Status Permitting Needs Improvement to Ensure Continued Progress

    EPA Pesticide Factsheets

    Report #2007-P-00005, December 4, 2006. Interim status is a temporary designation, but some units have existed for as many as 25 years without formal issuance or denial of a permit, or other regulatory controls.

  13. Interim report to the U.S. Congress on the Nonmotorized Transportation Pilot Program, SAFETEA-LU Section 1807

    DOT National Transportation Integrated Search

    2007-11-01

    This interim report to Congress summarizes the progress and initial results of the Federal Highway Administrations (FHWA) and the four pilot communities participation in the Nonmotorized Transportation Pilot Program (NTPP) from its inception th...

  14. The use of robotics for nondestructive inspection of steel highway bridges and structures: interim report.

    DOT National Transportation Integrated Search

    1998-01-01

    This interim report describes the progress during the first year of a project to develop robotics hardware for nondestructive evaluation of steel structures. The project objectives are to (1) develop and test an improved prototype (POLECAT-II) crawli...

  15. Different predictive values of interim 18F-FDG PET/CT in germinal center like and non-germinal center like diffuse large B-cell lymphoma.

    PubMed

    Kim, Jihyun; Lee, Jeong-Ok; Paik, Jin Ho; Lee, Won Woo; Kim, Sang Eun; Song, Yoo Sung

    2017-01-01

    Diffuse large B-cell lymphoma (DLBCL) is a pathologically heterogeneous disease with different prognoses according to its molecular profiles. Despite the broad usage of 18 F-fluoro-2-dexoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT), previous studies that have investigated the value of interim 18 F-FDG PET/CT in DLBCL have given the controversial results. The purpose of this study was to evaluate the prognostic value of interim 18 F-FDG PET/CT in DLBCL according to germinal center B cell-like (GCB) and non-GCB molecular profiling. We enrolled 118 newly diagnosed DLBCL patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). Interim 18 F-FDG PET/CT scans performed after 2 or 3 cycles of R-CHOP treatment were evaluated based on the Lugano response criteria. Patients were grouped as GCB or non-GCB molecular subtypes according to immunohistochemistry results of CD10, BCL6, and MUM1, based on Hans' algorithm. In total 118 DLBCL patients, 35 % were classified as GCB, and 65 % were classified as non-GCB. Interim PET/CT was negative in 70 %, and positive in 30 %. During the median follow-up period of 23 months, the positive interim 18 F-FDG PET/CT group showed significantly inferior progression free survival (PFS) compared to the negative interim 18 F-FDG PET/CT group (P = 0.0004) in entire patients. A subgroup analysis according to molecular profiling demonstrated significant difference of PFS between the positive and negative interim 18 F-FDG PET groups in GCB subtype of DLBCL (P = 0.0001), but there was no significant difference of PFS between the positive and negative interim 18 F-FDG PET groups in non-GCB subtype of DLBCL. Interim 18 F-FDG PET/CT scanning had a significant predictive value for disease progression in patients with the GCB subtype of DLBCL treated with R-CHOP, but not in those with the non-GCB subtype. Therefore, molecular profiles of DLBCL should be considered for interim 18 F-FDG PET/CT practice.

  16. Making the Most of Interim Assessment Data. Lessons from Philadelphia

    ERIC Educational Resources Information Center

    Christman, Jolley Bruce; Neild, Ruth Curran; Bulkley, Katrina; Blanc, Suzanne; Liu, Roseann; Mitchell, Cecily; Travers, Eva

    2009-01-01

    Under No Child Left Behind, urban school districts have increasingly turned to interim assessments, administered at regular intervals, to help gauge student progress in advance of annual state exams. These assessments have spawned growing debate among educators, assessment experts, and the testing industry: are they worth the significant…

  17. THE EDUCATION AND EMPLOYMENT OF TECHNICIANS. INTERIM REPORT.

    ERIC Educational Resources Information Center

    BJORKQUIST, DAVID C., ED.

    THE TECHNICAL MANPOWER CONFERENCE, HELD AT THE PENNSYLVANIA STATE UNIVERSITY CAMPUS ON JANUARY 24 AND 25, 1968, WAS THE FIRST PHASE IN THE DISSEMINATION OF THE RESEARCH PROJECT, "EFFECTS OF FIELD AND JOB ORIENTED TECHNICAL RETRAINING ON MANPOWER UTILIZATION OF THE UNEMPLOYED." THE PRESENTATIONS IN PART I, INTENDED TO PROVIDE BACKGROUND…

  18. Radon Reduction Techniques in Schools: Interim Technical Guidance.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC.

    This technical document is intended to assist school facilities maintenance personnel in the selection, design, and operation of radon reduction systems in schools. The guidance contained in this document is based largely on research conducted in 1987 and 1988 in schools located in Maryland and Virginia. Researchers from the United States…

  19. A Summary on Progress in Materials Development for Advanced Lithium-ion Cells for NASA's Exploration Missions

    NASA Technical Reports Server (NTRS)

    Reid, Concha M.

    2011-01-01

    Vehicles and stand-alone power systems that enable the next generation of human missions to the moon will require energy storage systems that are safer, lighter, and more compact than current state-of-the-art (SOA) aerospace quality lithium-ion (Li-ion) batteries. NASA is developing advanced Li-ion cells to enable or enhance future human missions to Near Earth Objects, such as asteroids, planets, moons, libration points, and orbiting structures. Advanced, high-performing materials are required to provide component-level performance that can offer the required gains at the integrated cell level. Although there is still a significant amount of work yet to be done, the present state of development activities has resulted in the synthesis of promising materials that approach the ultimate performance goals. This paper on interim progress of the development efforts will present performance of materials and cell components and will elaborate on the challenges of the development activities and proposed strategies to overcome technical issues.

  20. Progress in Materials and Component Development for Advanced Lithium-ion Cells for NASA's Exploration Missions

    NASA Technical Reports Server (NTRS)

    Reid, Concha, M.; Reid, Concha M.

    2011-01-01

    Vehicles and stand-alone power systems that enable the next generation of human missions to the Moon will require energy storage systems that are safer, lighter, and more compact than current state-of-the- art (SOA) aerospace quality lithium-ion (Li-ion) batteries. NASA is developing advanced Li-ion cells to enable or enhance the power systems for the Altair Lunar Lander, Extravehicular Activities spacesuit, and rovers and portable utility pallets for Lunar Surface Systems. Advanced, high-performing materials are required to provide component-level performance that can offer the required gains at the integrated cell level. Although there is still a significant amount of work yet to be done, the present state of development activities has resulted in the synthesis of promising materials that approach the ultimate performance goals. This report on interim progress of the development efforts will elaborate on the challenges of the development activities, proposed strategies to overcome technical issues, and present performance of materials and cell components.

  1. Pupil Inquiry Behavior Analysis and Change Activity. Interim Project Report.

    ERIC Educational Resources Information Center

    Manion, Raymond C.

    This interim report discusses progress toward three major goals of the Pupil Inquiry Behavior Analysis and Change Activity: increased pupil inquiry, changed teacher behavior to facilitate pupil inquiry, and the development of a 32-week course of instruction to provide for these behavioral changes. Data currently available deals with the emotional…

  2. User Selection of Purchased Information Services. Interim Technical Report (June 1975-January 1976).

    ERIC Educational Resources Information Center

    Hall, Homer J.

    Interviews conducted in the first phase of a project to develop a method for user selection of purchased scientific and technical information services identified a number of relationship among different populations of users. Research scientists, engineers, and patent attorneys want convenient access to original data identified in the search.…

  3. Grant Closeout Requirements and Reports

    Cancer.gov

    Requirements and reports to comply with grant closeout, including Final Federal Financial Report (FFR, SF425); Final Research Performance Progress Report (FRPPR); Interim Research Performance Progress Report (IRPPR); Final Invention Statement (FIS, HHS

  4. Evaluation of Searching and Rescue (SAR) Method For Determining Local Wind Current

    DTIC Science & Technology

    1991-07-01

    JUL 10 1992 ("= Research ajJ Development Centerto 1082 Shennecossett Road . - Groton, CT 06340-6096 INTERIM REPORT July 1991 This document is...United States Coast Guard Research and Development Center 1082 Shennecossett Road Groton, CT 06340-6096 V ’C . l •• mU. Technical Report Documentation...Grant No. 1082 Shennecossett Road Groton, Connecticut 06340-6096 13. Type of Report and Period Covered 12. Sponsoring Agency Name and Address INTERIM

  5. 33 CFR 385.39 - Evaluating progress towards other water-related needs of the region provided for in the Plan.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROGRAMMATIC REGULATIONS... other. (3) The Department of the Army shall include these interim targets in appropriate Corps of... provided for in the Plan. These interim targets shall reflect the incremental accomplishment of the...

  6. 33 CFR 385.39 - Evaluating progress towards other water-related needs of the region provided for in the Plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROGRAMMATIC REGULATIONS... other. (3) The Department of the Army shall include these interim targets in appropriate Corps of... provided for in the Plan. These interim targets shall reflect the incremental accomplishment of the...

  7. 33 CFR 385.39 - Evaluating progress towards other water-related needs of the region provided for in the Plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROGRAMMATIC REGULATIONS... other. (3) The Department of the Army shall include these interim targets in appropriate Corps of... provided for in the Plan. These interim targets shall reflect the incremental accomplishment of the...

  8. 33 CFR 385.39 - Evaluating progress towards other water-related needs of the region provided for in the Plan.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROGRAMMATIC REGULATIONS... other. (3) The Department of the Army shall include these interim targets in appropriate Corps of... provided for in the Plan. These interim targets shall reflect the incremental accomplishment of the...

  9. 33 CFR 385.39 - Evaluating progress towards other water-related needs of the region provided for in the Plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROGRAMMATIC REGULATIONS... other. (3) The Department of the Army shall include these interim targets in appropriate Corps of... provided for in the Plan. These interim targets shall reflect the incremental accomplishment of the...

  10. Interim Status Closure Plan Open Burning Treatment Unit Technical Area 16-399 Burn Tray

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vigil-Holterman, Luciana R.

    2012-05-07

    This closure plan describes the activities necessary to close one of the interim status hazardous waste open burning treatment units at Technical Area (TA) 16 at the Los Alamos National Laboratory (LANL or the Facility), hereinafter referred to as the 'TA-16-399 Burn Tray' or 'the unit'. The information provided in this closure plan addresses the closure requirements specified in the Code of Federal Regulations (CFR), Title 40, Part 265, Subparts G and P for the thermal treatment units operated at the Facility under the Resource Conservation and Recovery Act (RCRA) and the New Mexico Hazardous Waste Act. Closure of themore » open burning treatment unit will be completed in accordance with Section 4.1 of this closure plan.« less

  11. Proceedings of the Lake Wilderness Attention Conference. Interim Technical Report, August 1, 1980 through September 30, 1980.

    ERIC Educational Resources Information Center

    Lansman, Marcy, Ed.; Hunt, Earl, Ed.

    This technical report contains papers prepared by the 11 speakers at the 1980 Lake Wilderness (Seattle, Washington) Conference on Attention. The papers are divided into general models, physiological evidence, and visual attention categories. Topics of the papers include the following: (1) willed versus automatic control of behavior; (2) multiple…

  12. Interim Joint Technical Assessment Report: Light-Duty Vehicle Greenhouse Gas Emission Standards and Corporate Average Fuel Economy Standards for Model Years 2017-2025

    EPA Pesticide Factsheets

    EPA and the NHTSA collaborated with CARB on this joint Technical Assessment Report to build on the success of the first phase of the National Program to regulate fuel economy and greenhouse gas (GHG) emissions from U.S. light-duty vehicles.

  13. Performance of Retrained Airmen in Air Force Technical Schools (Revised). Interim Report for Period January 1981-August 1982.

    ERIC Educational Resources Information Center

    Skinner, Mary J.; Alley, William E.

    Research was conducted to determine the effect of changing occupational specialties on the performance of Air Force retrained enlistees attending basic technical schools. The academic performance and attrition rates of approximately 20,000 retrainees and 230,000 nonprior-service enlistees (nonretrainees) attending 272 schools were compared.…

  14. 78 FR 67442 - Congestion Mitigation and Air Quality Improvement Program Interim Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... the CMAQ Program as a result of the enactment of the Moving Ahead for Progress in the 21st Century Act (MAP-21). The Interim Guidance also contains changes to clarify the 2008 CMAQ Program Guidance. Because... Act for the 21st Century (TEA-21) (Pub. L. 105-178; Oct. 1998) and the Safe, Accountable, Flexible...

  15. Liner for extrusion billet containers. Interim Technical Documentary Progress Report, February 1--April 30, 1963

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spachner, S. A.

    1963-05-01

    A shrink-fit assembly device for buildup of ceramiccoated liner and sleeve assemblies was tested and modified to develop desired temperatures and suitable heat distribution in sleeves, which were heated. Nine different compositions of fiber metal reinforced ceramic compacts were produced for preliminary evaluation of suitability for extrusion liner use. Procedures were developed for welding short, hollow ceramic cylinders of high-strength metal carbides and borides to form a ceramic extrusion liner of suitable length. Dissassembly tooling for rapid separation of shrink-fitted sleeves from a worn liner was designed, fabricated, and tested. Preliminary extrusion testing of an alumina-coated liner was carried out,more » using SAE 4340 steel billets extruded to rod at 12 : 1 and 16 : 1 ratios. No coating wear was noted after extrusion of 3 billets. (auth)« less

  16. Applied Reading Test--Forms A and B, Interim Manual, and Answer Sheets.

    ERIC Educational Resources Information Center

    Australian Council for Educational Research, Hawthorn.

    Designed for use in the selection of apprentices, trainees, technical and trade personnel, and any other persons who need to read and understand text of a technical nature, this Applied Reading Test specimen set contains six passages and 32 items, has a 30-minute time limit, and is presented in a reusable multiple choice test booklet. The specimen…

  17. Interim Exceptional Events Rule Frequently Asked Questions

    EPA Pesticide Factsheets

    Air agencies and other stakeholders have raised technical questions and issues related to implementation since the EPA promulgated the EER. This Question and Answer (Q&A) document is intended to respond to some of these frequently asked questions.

  18. DEVELOPMENT OF DIES FOR EXTRUSION OF COMPLEX SHAPES OF STEEL AND REFRACTORY ALLOYS. Interim Technical Documentary Progress Report to Aeronautical Systems Division for the Period September 16,1962 through December 31, 1962

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hunt, J.G.; Jenkins, R.G.; White, A.M.

    1963-03-01

    A number of ceramics, metallic compounds, and ceramic-metal composites were successfully hot pressed into the shape of die inserts. Steels were extruded through several of these for the purpose of evaluating the materials or to study methods of supporting the die inserts. Refractory metal inserts were also used in similar tests. Hot pressed inserts consisting of 80 vo1% Al/sub 2/O/ sub 3/--10 vol% W and 80 vol% ThO/sub 2/--10 vol% W cracked but did not erode. Sintered molybdenum inserts flowed excessively, whereas sintered tungsten inserts flowed to a lesser degree. A hard die casing with a slight shrink fit appearsmore » to be the most satisfactory method of support. (auth)« less

  19. Northeast Artificial Intelligence Consortium annual report. Volume 2. 1988. Discussing, using, and recognizing plans (NLP). Interim report, January-December 1988

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shapiro, S.C.; Woolf, B.

    The Northeast Artificial Intelligence Consortium (NAIC) was created by the Air Force Systems Command, Rome Air Development Center, and the Office of Scientific Research. Its purpose is to conduct pertinent research in artificial intelligence and to perform activities ancillary to this research. This report describes progress that has been made in the fourth year of the existence of the NAIC on the technical research tasks undertaken at the member universities. The topics covered in general are: versatile expert system for equipment maintenance, distributed AI for communications system control, automatic photointerpretation, time-oriented problem solving, speech understanding systems, knowledge base maintenance, hardwaremore » architectures for very large systems, knowledge-based reasoning and planning, and a knowledge acquisition, assistance, and explanation system. The specific topic for this volume is the recognition of plans expressed in natural language, followed by their discussion and use.« less

  20. Dip-coating process: Silicon sheet growth development for the large-area silicon sheet task of the low-cost silicon solar array project

    NASA Technical Reports Server (NTRS)

    Zook, J. D.; Heaps, J. D.; Maciolek, R. B.; Koepke, B. G.; Gutter, C. D.; Schuldt, S. B.

    1977-01-01

    The objective of this research program is to investigate the technical and economic feasibility of producing solar-cell-quality sheet silicon by coating one surface of carbonized ceramic substrates with a thin layer of large-grain polycrystalline silicon from the melt. The past quarter demonstrated significant progress in several areas. Seeded growth of silicon-on-ceramic (SOC) with an EFG ribbon seed was demonstrated. Different types of mullite were successfully coated with silicon. A new method of deriving minority carrier diffusion length, L sub n from spectral response measurements was evaluated. ECOMOD cost projections were found to be in good agreement with the interim SAMIS method proposed by JPL. On the less positive side, there was a decrease in cell performance which we believe to be due to an unidentified source of impurities.

  1. Geographic patterns of at-risk species: A technical document supporting the USDA Forest Service Interim Update of the 2000 RPA Assessment

    Treesearch

    Curtis H. Flather; Michael S. Knowles; Jason McNees

    2008-01-01

    This technical document supports the Forest Service's requirement to assess the status of renewable natural resources as mandated by the Forest and Rangeland Renewable Resources Planning Act of 1974. It updates past reports on the trends and geographic patterns of species formally listed as threatened or endangered under the Endangered Species Act of 1973. We...

  2. 2015 NWEA Measures of Academic Progress Normative Data

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2015

    2015-01-01

    By using carefully constructed measurement scales that span grades, Measures of Academic Progress (MAP) interim assessments from Northwest Evaluation Association™ (NWEA™) offer educators efficient and very accurate estimates of student achievement status within a subject. Before achievement test scores can be useful to educators, however, they…

  3. Results from the interim salt disposition program macrobatch 10 tank 21H qualification samples

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peters, T. B.; Bannochie, C. J.

    2017-02-23

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 10 for the Interim Salt Disposition Program (ISDP). This document reports characterization data on the samples of Tank 21H and fulfills the requirements of Deliverable 3 of the Technical Task Request (TTR). Further work will report the results of the Extraction-Scrub-Strip (ESS) testing (Task 5 of the TTR) using the Tank 21H material. Task 4 of the TTR (MST Strike) will not be completed for Salt Batch 10.

  4. Prognostic Value of Quantitative Metabolic Metrics on Baseline Pre-Sunitinib FDG PET/CT in Advanced Renal Cell Carcinoma

    PubMed Central

    Minamimoto, Ryogo; Barkhodari, Amir; Harshman, Lauren; Srinivas, Sandy; Quon, Andrew

    2016-01-01

    Purpose The objective of this study was to prospectively evaluate various quantitative metrics on FDG PET/CT for monitoring sunitinib therapy and predicting prognosis in patients with metastatic renal cell cancer (mRCC). Methods Seventeen patients (mean age: 59.0 ± 11.6) prospectively underwent a baseline FDG PET/CT and interim PET/CT after 2 cycles (12 weeks) of sunitinib therapy. We measured the highest maximum standardized uptake value (SUVmax) of all identified lesions (highest SUVmax), sum of SUVmax with maximum six lesions (sum of SUVmax), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) from baseline PET/CT and interim PET/CT, and the % decrease in highest SUVmax of lesion (%Δ highest SUVmax), the % decrease in sum of SUVmax, the % decrease in TLG (%ΔTLG) and the % decrease in MTV (%ΔMTV) between baseline and interim PET/CT, and the imaging results were validated by clinical follow-up at 12 months after completion of therapy for progression free survival (PFS). Results At 12 month follow-up, 6/17 (35.3%) patients achieved PFS, while 11/17 (64.7%) patients were deemed to have progression of disease or recurrence within the previous 12 months. At baseline, PET/CT demonstrated metabolically active cancer in all cases. Using baseline PET/CT alone, all of the quantitative imaging metrics were predictive of PFS. Using interim PET/CT, the %Δ highest SUVmax, %Δ sum of SUVmax, and %ΔTLG were also predictive of PFS. Otherwise, interim PET/CT showed no significant difference between the two survival groups regardless of the quantitative metric utilized including MTV and TLG. Conclusions Quantitative metabolic measurements on baseline PET/CT appears to be predictive of PFS at 12 months post-therapy in patients scheduled to undergo sunitinib therapy for mRCC. Change between baseline and interim PET/CT also appeared to have prognostic value but otherwise interim PET/CT after 12 weeks of sunitinib did not appear to be predictive of PFS. PMID:27123976

  5. Population and harvest trends of big game and small game species: a technical document supporting the USDA Forest Service Interim Update of the 2000 RPA Assessment

    Treesearch

    Curtis H. Flather; Michael S. Knowles; Stephen J. Brady

    2009-01-01

    This technical document supports the Forest Service's requirement to assess the status of renewable natural resources as mandated by the Forest and Rangeland Renewable Resources Planning Act of 1974 (RPA). It updates past reports on national and regional trends in population and harvest estimates for species classified as big game and small game. The trends...

  6. INTERIM METHOD FOR THE DETERMINATION OF ASBESTOS IN BULK INSULATION SAMPLES

    EPA Science Inventory

    The U.S. Environmental Protection Agency Asbestos-in-Schools Program was established in March, 1979 to provide information and technical assistance to the public for addressing problems presented by asbestos-containing insulation materials in school buildings. Because there were ...

  7. 75 FR 35672 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ...This interim rule lists communities where modification of the Base (1% annual-chance) Flood Elevations (BFEs) is appropriate because of new scientific or technical data. New flood insurance premium rates will be calculated from the modified BFEs for new buildings and their contents.

  8. 75 FR 25110 - Inmate Communication With News Media: Removal of Byline Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... DEPARTMENT OF JUSTICE Bureau of Prisons 28 CFR Part 540 [BOP-1149] RIN 1120-AB49 Inmate Communication With News Media: Removal of Byline Regulations AGENCY: Bureau of Prisons, Justice Department. ACTION: Interim final rule; technical correction. [[Page 25111

  9. Institutional Effectiveness Summary Report, 2001.

    ERIC Educational Resources Information Center

    Burless, Bridget

    This document discusses institutional effectiveness at Florence-Darlington Technical College (FDTC) (South Carolina) for the 2000-2001 academic year. Full and/or interim report summaries are provided for advising procedures, library resources, and for the following departments: Accounting, Automated Office, Office Systems Technology, Health Care…

  10. 40 CFR 265.1059 - Standards: Delay of repair.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 265.1059 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... technically infeasible without a hazardous waste management unit shutdown. In such a case, repair of this...

  11. The DENALI Trial: an interim analysis of a prospective, multicenter study of the Denali retrievable inferior vena cava filter.

    PubMed

    Stavropoulos, S William; Sing, Ronald F; Elmasri, Fakhir; Silver, Mitchell J; Powell, Alex; Lynch, Frank C; Aal, Ahmed Kamel Abdel; Lansky, Alexandra J; Settlage, Richard A; Muhs, Bart E

    2014-10-01

    To assess safety and effectiveness of a nitinol retrievable inferior vena cava (IVC) filter in patients who require caval interruption to protect against pulmonary embolism (PE). Two hundred patients with temporary indications for an IVC filter were enrolled in this prospective, multicenter clinical study. Patients undergoing filter implantation were to be followed for 2 years or for 30 days after filter retrieval. At the time of the present interim report, all 200 patients had been enrolled in the study, and 160 had undergone a retrieval attempt or been followed to 6 months with their filter in place. Primary study endpoints included technical and clinical success of filter placement and retrieval. Patients were also evaluated for recurrent PE, new or worsening deep vein thrombosis, and filter migration, fracture, penetration, and tilt. Clinical success of placement was achieved in 94.5% of patients (172 of 182), with a one-sided lower limit of the 95% confidence interval of 90.1%. Technical success rate of filter placement was 99.5%. Technical success rate of retrieval was 97.3%; 108 filters were retrieved in 111 attempts. In two cases, the filter apex could not be engaged with a snare, and one device was engaged but could not be removed. Filter retrievals occurred at a mean indwell time of 165 days (range, 5-632 d). There were no instances of filter fracture, migration, or tilt greater than 15° at the time of retrieval or 6-month follow-up. In this interim report, the nitinol retrievable IVC filter provided protection against pulmonary embolism, and the device could be retrieved with a low rate of complications. Copyright © 2014 SIR. Published by Elsevier Inc. All rights reserved.

  12. Technical support documentation for the Automated Residential Energy Standard (ARES) in support of proposed interim energy conservation voluntary performance standards for new non-federal residential buildings: Volume 2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    The Automated Residential Energy Standard (ARES) program is designed to identify levels of thermal integrity (e.g., insulation levels, glazing layers, equipment efficiencies, etc.) that are cost effective for typical residential structures and to create a residential energy standard based on these levels. This document contains technical background the explains the data and the algorithms used by the program.

  13. Global Spent Fuel Logistics Systems Study (GSFLS). Volume 3A. GSFLS technical analysis (appendix). Interim report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kriger, A.

    1978-01-31

    This report is a part of the interim report documentation for the Global Spent Fuel Logistics System (GSFLS) study. The technical and financial considerations underlying a global spent fuel logistics systems have been studied and are reported. The Pacific Basin is used as a model throughout this report; however the stated methodology and, in many cases, considerations and conclusions are applicable to other global regions. Spent fuel discharge profiles for Pacific Basin Countries were used to determine the technical systems requirements for alternative concepts. Functional analyses and flows were generated to define both system design requirements and logistics parameters. Amore » technology review was made to ascertain the state-of-the-art of relevant GSFLS technical systems. Modular GSFLS facility designs were developed using the information generated from the functional analysis and technology review. The modular facility designs were used as a basis for siting and cost estimates for various GSFLS alternatives. Various GSFLS concepts were analyzed from a financial and economic perspective in order to provide total concepts costs and ascertain financial and economic sensitivities to key GSFLS variations. Results of the study include quantification of GSFLS facility and hardware requirements; drawings of relevant GSFLS facility designs; system cost estimates; financial reports - including user service charges; and comparative analyses of various GSFLS alternatives.« less

  14. 75 FR 6839 - Technical Service Provider Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-12

    ... Executive Order 12866, the Office of Management and Budget determined that this final rule is not a... or are eligible to participate in conservation programs to help them make land management decisions...: Covered Programs. The interim final rule incorporated reference to the Agricultural Management Assistance...

  15. Ecological Risk Assessment Guidance for Superfund: Process for Designing and Conducting Ecological Risk Assessments - Interim Final

    EPA Pesticide Factsheets

    This document provides guidance to site managers and Remedial Project Managers who are legally responsible for the management of a site on how to design and conduct technically defensible ecological risk assessments for the Superfund program.

  16. High performance concrete in Washington state SR 18/SR 516 overcrossing : interim report on girder monitoring

    DOT National Transportation Integrated Search

    1999-04-30

    This report documents a sample of heavy-duty truck activity. This research effort was originated by the Planning and Technical Support Division of the California Air Resources Board (CARB) and jointly supported by the Federal Highway Administration (...

  17. Baltimore Community Schools: Promise & Progress

    ERIC Educational Resources Information Center

    Durham, Rachel E.; Connolly, Faith

    2016-01-01

    This report documents the interim progress of the Baltimore Community School (CommSch) strategy by examining outcomes for the 2014-15 school year. Results show that CommSch parents more often reported being connected with community resources by school staff compared to parents at other schools. They also were more likely to report that school…

  18. Pewaukee School District, Wisconsin. Case Study: Measures of Academic Progress

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2015

    2015-01-01

    For more than a decade, Pewaukee School District Superintendent JoAnn Sternke has watched her district get better and better at its mission: opening the door to each student's future. The Wisconsin district began using Measures of Academic Progress® (MAP®) computer adaptive interim assessments from Northwest Evaluation Association™ (NWEA™) in 2004…

  19. Progress Report 2013. Turnaround Arts Initiative

    ERIC Educational Resources Information Center

    Stoelinga, Sara Ray; Joyce, Katie; Silk, Yael

    2013-01-01

    This interim progress report provides a look at Turnaround Arts schools in their first year, including: (1) a summary of the evaluation design and research questions; (2) a preliminary description of strategies used to introduce the arts in Turnaround Arts schools; and (3) a summary of school reform indicators and student achievement data at…

  20. ISO Guest Observer Data Analysis and LWS Instrument Team Activities

    NASA Technical Reports Server (NTRS)

    Smith, Howard

    2001-01-01

    The following is an interim annual report. Dr. Smith is currently on an extended TDY to the Istituto di Fisica dello Spazio Interplanetario (IFSI) at the Consilio Nazionale delle Richerche (CNR) in Rome, Italy, where he has been working on a related NASA grant in support of analysis of Infrared Space Observatory (ISO) data on star formation in Ultra Luminous Infrared Galaxies and our galaxy. Work emphasizes development of metal mesh grids for use in spacecraft, and the design and fabrication of test elements by the Naval Research Laboratory, Washington D.C. Work has progressed well, but slowly, on that program due to the departure of a key engineer. NASA has been advised of the delay, and granted a no-cost extension, whereby SAO has authorized a delay in the final report from NRL. Nevertheless NRL has continued to make progress. Two papers have been submitted to refereed journals related to this program, and a new design for mesh operating in the 20-40 micron region has been developed. Meetings continue through the summer on these items. A new technical scientist has been made a job offer and hopefully will be on board NRL shortly, although most of the present grant work is already completed. A more complete report, with copies of the submitted papers, designs, and other measures of progress, will be submitted to NASA in September when Dr. Smith returns from his current TDY.

  1. Transportation Systems Center Bibliography of Technical Reports, July 1970 - December 1976,

    DTIC Science & Technology

    1977-04-01

    Systems Center. AD-733-763 Judith Gertler, Herbert Glynn, Vivian Hobbs, Frederick Interim Report. June 1971. 16p. Woolfall. AD-733-764 Air Traffic Control...of Deployment Cost Analysis .. .......... FAA-76-20 Airspace Control Environmnent Simulator - Final Report.... ............ .. TSC-131.3 *All- Wether

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peters, T. B.; Bannochie, C. J.

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of verification of Macrobatch (Salt Batch) 11 for the Interim Salt Disposition Program (ISDP) for processing. This document reports characterization data on the samples of Tank 21H and fulfills the requirements of Deliverable 3 of the Technical Task Request (TTR).

  3. In-place cement stabilized base reconstruction techniques interim report, "construction and two year evaluation" : technical summary.

    DOT National Transportation Integrated Search

    2002-08-01

    The purpose of this research is to evaluate the effectiveness of soil cement shrinkage crack mitigation techniques. Ten test sections, 1000 feet long, were constructed on LA 89 in Vermilion Parish. The shrinkage crack mitigation methods being evaluat...

  4. 48 CFR 2052.211-71 - Technical progress report.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Technical progress report... Technical progress report. As prescribed at 2011.104-70(b), the contracting officer shall insert the... solicitation. Technical Progress Report (JAN 1993) The contractor shall provide a monthly Technical Progress...

  5. 48 CFR 2052.211-71 - Technical progress report.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Technical progress report... Technical progress report. As prescribed at 2011.104-70(b), the contracting officer shall insert the... solicitation. Technical Progress Report (JAN 1993) The contractor shall provide a monthly Technical Progress...

  6. 48 CFR 2052.211-71 - Technical progress report.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Technical progress report... Technical progress report. As prescribed at 2011.104-70(b), the contracting officer shall insert the... solicitation. Technical Progress Report (JAN 1993) The contractor shall provide a monthly Technical Progress...

  7. 48 CFR 2052.211-71 - Technical progress report.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Technical progress report... Technical progress report. As prescribed at 2011.104-70(b), the contracting officer shall insert the... solicitation. Technical Progress Report (JAN 1993) The contractor shall provide a monthly Technical Progress...

  8. 78 FR 13478 - Compassionate Release; Technical Changes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... (Bureau) makes a minor change to remove an administrative level of review from the processing of a... interim rule, the Bureau of Prisons (Bureau) makes a minor change to remove an administrative level of review from the processing of a Compassionate Release request packet. DATES: This rule is effective April...

  9. Emulytics for Cyber-Enabled Physical Attack Scenarios: Interim LDRD Report of Year One Results.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Clem, John; Urias, Vincent; Atkins, William Dee

    Sandia National Laboratories has funded the research and development of a new capability to interactively explore the effects of cyber exploits on the performance of physical protection systems. This informal, interim report of progress summarizes the project’s basis and year one (of two) accomplishments. It includes descriptions of confirmed cyber exploits against a representative testbed protection system and details the development of an emulytics capability to support live, virtual, and constructive experiments. This work will support stakeholders to better engineer, operate, and maintain reliable protection systems.

  10. Pembrolizumab for Ipilimumab-Resistant Melanoma

    Cancer.gov

    KEYNOTE-002 was designed to test the safety and efficacy of two doses of pembrolizumab compared with chemotherapy in patients with ipilimumab-resistant melanoma; interim results show that pembrolizumab improves progression-free survival for these patients

  11. CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkin's and aggressive non-hodgkin's lymphomas.

    PubMed

    Ganeshan, B; Miles, K A; Babikir, S; Shortman, R; Afaq, A; Ardeshna, K M; Groves, A M; Kayani, I

    2017-03-01

    The purpose of this study was to investigate the ability of computed tomography texture analysis (CTTA) to provide additional prognostic information in patients with Hodgkin's lymphoma (HL) and high-grade non-Hodgkin's lymphoma (NHL). This retrospective, pilot-study approved by the IRB comprised 45 lymphoma patients undergoing routine 18F-FDG-PET-CT. Progression-free survival (PFS) was determined from clinical follow-up (mean-duration: 40 months; range: 10-62 months). Non-contrast-enhanced low-dose CT images were submitted to CTTA comprising image filtration to highlight features of different sizes followed by histogram-analysis using kurtosis. Prognostic value of CTTA was compared to PET FDG-uptake value, tumour-stage, tumour-bulk, lymphoma-type, treatment-regime, and interim FDG-PET (iPET) status using Kaplan-Meier analysis. Cox regression analysis determined the independence of significantly prognostic imaging and clinical features. A total of 27 patients had aggressive NHL and 18 had HL. Mean PFS was 48.5 months. There was no significant difference in pre-treatment CTTA between the lymphoma sub-types. Kaplan-Meier analysis found pre-treatment CTTA (medium feature scale, p=0.010) and iPET status (p<0.001) to be significant predictors of PFS. Cox analysis revealed that an interaction between pre-treatment CTTA and iPET status was the only independent predictor of PFS (HR: 25.5, 95% CI: 5.4-120, p<0.001). Specifically, pre-treatment CTTA risk stratified patients with negative iPET. CTTA can potentially provide prognostic information complementary to iPET for patients with HL and aggressive NHL. • CT texture-analysis (CTTA) provides prognostic information complementary to interim FDG-PET in Lymphoma. • Pre-treatment CTTA and interim PET status were significant predictors of progression-free survival. • Patients with negative interim PET could be further stratified by pre-treatment CTTA. • Provide precision surveillance where additional imaging reserved for patients at greatest recurrence-risk. • Assists in risk-adapted treatment strategy based on interim PET and CTTA.

  12. LINER FOR EXTRUSION BILLET CONTAINERS. Interim Technical Documentary Progress Report, May 4-August 4, 1963

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spachner, S.A.

    1964-10-31

    Rokide-process alumina and zirconia coatings and a Udimet 700 superalloy liner were evaluated by extrusion of 31/2-in. billets of Inconel 713C, Udimet 700, SAE 4340, PH15--7Mo, and TZM alloys, using rod extrusion dies of temperatures were in the 1900 to 2250 deg F and 2900 to 3600 deg F ranges. Both alumina and zirconia coatings provided adequate protection to the support tooling at temperatures to 3450 deg F. Alumina coatings showed wear at temperatures over 2900 deg F, but may be serviceable to 3450 deg F. Zirconia coatings showed erratic results. One coating did withstand extrusion at 3450 deg Fmore » without apparent wear. The Udimet 700 liner did not show wear at 2000 deg F, but did react with the TZM billet at 3600 deg F. T-section die design was modified to prevent die cracking during extrusion and reduce coating grinding costs. (auth)« less

  13. Interim analysis of STR effectiveness

    DOT National Transportation Integrated Search

    1978-01-01

    The present report describes the status of the NHTSA Short Term Rehabilitation Study (STR) as of December, 1977, and summarizes the progress of data collection efforts by the eleven participating ASAP projects. Outcome measures considered as indicati...

  14. Palbociclib for Advanced Breast Cancer

    Cancer.gov

    An interim analysis of the PALOMA3 trial shows that women with hormone receptor-positive metastatic breast cancer who received palbociclib plus fulvestrant had longer progression-free survival rates than women who received a placebo plus fulvestrant.

  15. Visions for Natural Resource Education and Ecosystem Science for the 21st Century. An Interim Report.

    ERIC Educational Resources Information Center

    Cudmore, Wynn, Ed.; Kelly, Susie, Ed.

    The Northwest Center for Sustainable Resources (NCSR) is a partnership of educators and numerous agencies dealing with natural resource management. NCSR emphasizes the ecosystem as a central theme in natural resource technical education. This booklet explains NCSR's relationship to secondary and higher education, describes NCSR programs and…

  16. FY 1987 current fiscal year work plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This Current Year Work Plan presents a detailed description of the activities to be performed by the Joint Integration Office during FY87. It breaks down the activities into two major work areas: Program Management and Program Analysis. Program Management is performed by the JIO by providing technical planning and guidance for the development of advanced TRU waste management capabilities. This includes equipment/facility design, engineering, construction, and operations. These functions are integrated to allow transition from interim storage to final disposition. JIO tasks include program requirements identification, long-range technical planning, budget development, program planning document preparation, task guidance, task monitoring, informationmore » gathering and task reporting to DOE, interfacing with other agencies and DOE lead programs, integrating public involvement with program efforts, and preparation of program status reports for DOE. Program Analysis is performed by the JIO to support identification and assessment of alternatives, and development of long-term TRU waste program capabilities. This work plan includes: system analyses, requirements analyses, interim and procedure development, legislative and regulatory analyses, dispatch and traffic analyses, and data bases.« less

  17. FOD Prevention at NASA-Marshall Space Flight Center

    NASA Technical Reports Server (NTRS)

    Lowrey, Nikki M.

    2011-01-01

    NASA now requires all flight hardware projects to develop and implement a Foreign Object Damage (FOD) Prevention Program. With the increasing use of composite and bonded structures, NASA now also requires an Impact Damage Protection Plan for these items. In 2009, Marshall Space Flight Center released an interim directive that required all Center organizations to comply with FOD protocols established by on-site Projects, to include prevention of impact damage. The MSFC Technical Standards Control Board authorized the development of a new MSFC technical standard for FOD Prevention.

  18. Tribal child welfare. Interim final rule.

    PubMed

    2012-01-06

    The Administration for Children and Families (ACF) is issuing this interim final rule to implement statutory provisions related to the Tribal title IV-E program. Effective October 1, 2009, section 479B(b) of the Social Security Act (the Act) authorizes direct Federal funding of Indian Tribes, Tribal organizations, and Tribal consortia that choose to operate a foster care, adoption assistance and, at Tribal option, a kinship guardianship assistance program under title IV-E of the Act. The Fostering Connections to Success and Increasing Adoptions Act of 2008 requires that ACF issue interim final regulations which address procedures to ensure that a transfer of responsibility for the placement and care of a child under a State title IV-E plan to a Tribal title IV-E plan occurs in a manner that does not affect the child's eligibility for title IV-E benefits or medical assistance under title XIX of the Act (Medicaid) and such services or payments; in-kind expenditures from third-party sources for the Tribal share of administration and training expenditures under title IV-E; and other provisions to carry out the Tribal-related amendments to title IV-E. This interim final rule includes these provisions and technical amendments necessary to implement a Tribal title IV-E program.

  19. Contractors Road Heavy Equipment Area SWMU 055 Corrective Measures Implementation Progress Report Kennedy Space Center, Florida

    NASA Technical Reports Server (NTRS)

    Johnson, Jill W. (Compiler)

    2015-01-01

    This Corrective Measures Implementation (CMI) Progress Report documents: (i) activities conducted as part of supplemental assessment activities completed from June 2009 through November 2014; (ii) Engineering Evaluation (EE) Advanced Data Packages (ADPs); and (iii) recommendations for future activities related to corrective measures at the Site. Applicable meeting minutes are provided as Appendix A. The following EE ADPs for CRHE are included with this CMI Progress Report: center dot Supplemental Site Characterization ADP (Step 1 EE) (Appendix B) center dot Site Characterization ADP (Step 1 EE) for Hot Spot 1 (HS1) (Appendix C) center dot Remedial Alternatives Evaluation (Step 2 EE) ADP for HS1 (Appendix D) center dot Interim Measures Work Plan (Step 3 EE) ADP for HS1 (Appendix E) center dot Site Characterization ADP (Step 1 EE) ADP for Hot Spot 2 (HS2), High Concentration Plume (HCP), and Low Concentration Plume (LCP) (Appendix F) A summary of direct-push technology (DPT) and groundwater monitoring well sampling results are provided in Appendices G and H, respectively. The Interim Land Use Control Implementation Plan (LUCIP) is provided as Appendix I. Monitoring well completion reports, other applicable field forms, survey data, and analytical laboratory reports are provided as Appendices J through M, respectively, in the electronic copy of this document. Selected Site photographs are provided in Appendix N. The interim groundwater monitoring plan and document revision log are included as Appendices O and P, respectively. KSC Electronic Data Deliverable (KEDD) files are provided on the attached compact disk.

  20. Comparative risk assessments for the production and interim storage of glass and ceramic waste forms: Defense waste processing facility

    NASA Astrophysics Data System (ADS)

    Huang, J. C.; Wright, W. V.

    1982-04-01

    The Defense Waste Processing Facility (DWPF) for immobilizing nuclear high level waste (HLW) is scheduled to be built. High level waste is produced when reactor components are subjected to chemical separation operations. Two candidates for immobilizing this HLW are borosilicate glass and crystalline ceramic, either being contained in weld sealed stainless steel canisters. A number of technical analyses are being conducted to support a selection between these two waste forms. The risks associated with the manufacture and interim storage of these two forms in the DWPF are compared. Process information used in the risk analysis was taken primarily from a DWPF processibility analysis. The DWPF environmental analysis provided much of the necessary environmental information.

  1. A pavement management research program for Oregon highways : interim report.

    DOT National Transportation Integrated Search

    1985-03-01

    This is the first in a series of reports documenting progress on a statewide pavement management research project. The overall project is conducting research into pavement life cycles of different rehabilitation treatment; the cost-effectiveness of e...

  2. Shale embankment construction criteria : experimental feature interim report.

    DOT National Transportation Integrated Search

    1985-06-01

    The research was conducted in the summer of 1983 during the realignment construction of the Mystic Creek - Camas Valley section on the Coos Bay - Roseburg Highway. Construction is still in progress. As outlined in the experimental features work plan ...

  3. A quality assurance audit: phase III trial of maximal androgen deprivation in prostate cancer (TROG 96.01).

    PubMed

    Steigler, A; Mameghan, H; Lamb, D; Joseph, D; Matthews, J; Franklin, I; Turner, S; Spry, N; Poulsen, M; North, J; Kovacev, O; Denham, J

    2000-02-01

    In 1997 the Trans-Tasman Radiation Oncology Group (TROG) performed a quality assurance (QA) audit of its phase III randomized clinical trial investigating the effectiveness of different durations of maximal androgen deprivation prior to and during definitive radiation therapy for locally advanced carcinoma of the prostate (TROG 96.01). The audit reviewed a total of 60 cases from 15 centres across Australia and New Zealand. In addition to verification of technical adherence to the protocol, the audit also incorporated a survey of centre planning techniques and a QA time/cost analysis. The present report builds on TROG's first technical audit conducted in 1996 for the phase III accelerated head and neck trial (TROG 91.01) and highlights the significant progress TROG has made in the interim period. The audit provides a strong validation of the results of the 96.01 trial, as well as valuable budgeting and treatment planning information for future trials. Overall improvements were detected in data quality and quantity, and in protocol compliance, with a reduction in the rate of unacceptable protocol violations from 10 to 4%. Audit design, staff education and increased data management resources were identified as the main contributing factors to these improvements. In addition, a budget estimate of $100 per patient has been proposed for conducting similar technical audits. The next major QA project to be undertaken by TROG during the period 1998-1999 is an intercentre dosimetry study. Trial funding and staff education have been targeted as the key major issues essential to the continued success and expansion of TROG's QA programme.

  4. A SUGGESTED CURRICULUM GUIDE FOR ELECTRO-MECHANICAL TECHNOLOGY ORIENTED SPECIFICALLY TO THE COMPUTER AND BUSINESS MACHINE FIELDS. INTERIM REPORT.

    ERIC Educational Resources Information Center

    LESCARBEAU, ROLAND F.; AND OTHERS

    A SUGGESTED POST-SECONDARY CURRICULUM GUIDE FOR ELECTRO-MECHANICAL TECHNOLOGY ORIENTED SPECIFICALLY TO THE COMPUTER AND BUSINESS MACHINE FIELDS WAS DEVELOPED BY A GROUP OF COOPERATING INSTITUTIONS, NOW INCORPORATED AS TECHNICAL EDUCATION CONSORTIUM, INCORPORATED. SPECIFIC NEEDS OF THE COMPUTER AND BUSINESS MACHINE INDUSTRY WERE DETERMINED FROM…

  5. 75 FR 14323 - Requirements for Implementing Sections 1512, 1605, and 1606 of the American Recovery and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... sections of the interim final guidance at 2 CFR part 176 that pertain to international agreements. These amendments reflect changes with respect to U.S. international obligations since the publication of the... international agreements. First, it makes a technical correction to section 176.90(a). Second, it changes the...

  6. A Comparison of Learning Environments: All That Glitters... Interim Technical Paper for Period January 1990-July 1991.

    ERIC Educational Resources Information Center

    Shute, Valerie J.

    Aptitude-treatment interactions (ATIs) refer to the covariation between learner characteristic and instructional treatment in relation to some outcome measure. To systematically test for ATI, an intelligent tutoring system instructing in basic principles of electricity was chosen as a complex but controlled learning task. Two learning environments…

  7. Polyphosphazene Solid Electrolytes.

    DTIC Science & Technology

    1984-10-01

    soL..I’IIN ’ . LAV A - .:.u.s 009 ’-" 4. T .. T. edSutoe .TVCO EO T EI O Polyphosphazene Solid Electrolytes Interim Technical Repor 6. PEAFORMING RG ...Y. T.; Whitmore , D. H. Solid State Ionics 1982, 7, 129. (10) Bauerle, J. E. J. Phys. Chem. Solids 1969, 30, 2657. (11) MacDonald, J. R. J. Chem. Phys

  8. 75 FR 81843 - Amendments to Regulations Regarding Eligibility for a Medicare Prescription Drug Subsidy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ..., during regular business hours, by arranging with the contact person identified below. FOR FURTHER... interim final rule, we invite your comments on how to make rules easier to understand. For example: [[Page... diagrams? What else could we do to make the rule easier to understand? Does the rule contain technical...

  9. A Guide for Planning Facilities for Occupational Preparation Programs in Metallurgy Technology. Interim Report. Research 28.

    ERIC Educational Resources Information Center

    German, Carl, Jr.

    The major purpose of this guide is to elicit the information necessary for writing educational specifications for facilities to house technical education programs in metallurgy. It is organized in these parts: (1) Part I discusses the major purpose, underlying assumptions, recent instructional trends, and guiding principles utilized in the…

  10. Human-Machine Teams: The Social Frontier

    DTIC Science & Technology

    2015-12-01

    Trust & Interaction Branch December 2015 Interim Report Distribution A. Approved for public release AIR FORCE RESEARCH LABORATORY 711TH HUMAN...711th Human Performance Wing Air Force Research Laboratory This report is published in the interest of scientific and technical information exchange... Research Laboratory 711th Human Performance Wing Human Effectiveness Directorate Human Centered ISR Division Human Trust & Interaction Branch Wright

  11. Investigation of Electronic Generation of Visual Images for Air Force Technical Training. Interim Report for Period May 1974-October 1975.

    ERIC Educational Resources Information Center

    Filinger, Ronald H.; Hall, Paul W.

    Because large scale individualized learning systems place excessive demands on conventional means of producing audiovisual software, electronic image generation has been investigated as an alternative. A prototype, experimental device, Scanimate-500, was designed and built by the Computer Image Corporation. It uses photographic, television, and…

  12. Accidental Government Documents Librarian: A Review of Experiences and Training Needs of Interim Documents Librarians

    ERIC Educational Resources Information Center

    Yelinek, Kathryn; Hinchcliff, Marilou

    2009-01-01

    The results of a survey to determine the training needs and normative experiences of temporary government documents librarians are presented. The results indicate that temporary librarians tend to work in academia, have been in librarianship for a shorter time period, and have fewer technical processing skills than permanent documents librarians.…

  13. Taxonomy of Learning Skills. Interim Technical Report for the Period February 1986-1987.

    ERIC Educational Resources Information Center

    Kyllonen, Patrick C.; Shute, Valerie J.

    Questions concerning individual differences in learning ability may be more precisely addressed in light of an agreed-upon taxonomy of learning skills. Existing taxonomies are reviewed, and their shortcomings are described. A taxonomy is then proposed based on a synthesis of current thought consisting of four dimensions: the forms of knowledge;…

  14. TRU Waste Management Program. Cost/schedule optimization analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Detamore, J.A.; Raudenbush, M.H.; Wolaver, R.W.

    This Current Year Work Plan presents in detail a description of the activities to be performed by the Joint Integration Office Rockwell International (JIO/RI) during FY86. It breaks down the activities into two major work areas: Program Management and Program Analysis. Program Management is performed by the JIO/RI by providing technical planning and guidance for the development of advanced TRU waste management capabilities. This includes equipment/facility design, engineering, construction, and operations. These functions are integrated to allow transition from interim storage to final disposition. JIO/RI tasks include program requirements identification, long-range technical planning, budget development, program planning document preparation, taskmore » guidance development, task monitoring, task progress information gathering and reporting to DOE, interfacing with other agencies and DOE lead programs, integrating public involvement with program efforts, and preparation of reports for DOE detailing program status. Program Analysis is performed by the JIO/RI to support identification and assessment of alternatives, and development of long-term TRU waste program capabilities. These analyses include short-term analyses in response to DOE information requests, along with performing an RH Cost/Schedule Optimization report. Systems models will be developed, updated, and upgraded as needed to enhance JIO/RI's capability to evaluate the adequacy of program efforts in various fields. A TRU program data base will be maintained and updated to provide DOE with timely responses to inventory related questions.« less

  15. FY 1986 current fiscal year work plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This Current Year Work Plan presents in detail a description of the activities to be performed by the Joint Integration Office/RI during FY86. It breaks down the activities into two major work areas: Program Management and Program Analysis. Program Management is performed by the JIO/RI by providing technical planning and guidance for the development of advanced TRU waste management capabilities. This includes equipment/facility design, engineering, construction, and operations. These functions are integrated to allow transition from interim storage to final disposition. JIO/RI tasks include program requirements identification, long-range technical planning, budget development, program planning document preparation, task guidance development, taskmore » monitoring, task progress information gathering and reporting to DOE, interfacing with other agencies and DOE lead programs, integrating public involvement with program efforts, and preparation of reports for DOE detailing program status. Program Analysis is performed by the JIO/RI to support identification and assessment of alternatives, and development of long-term TRU waste program capabilities. These analyses include short term analyses in response to DOE information requests, along with performing an RH Cost/Schedule Optimization report. System models will be developed, updated, and upgraded as needed to enhance JIO/RI's capability to evaluate the adequacy of program efforts in various fields. A TRU program data base will be maintained and updated to provide DOE with timely responses to inventory related questions.« less

  16. Region 5: Ohio Canton - Massilon Adequate Letter (2/10/2010)

    EPA Pesticide Factsheets

    This is a letter from John Mooney, Chief, to Jenifer Hunter regarding Ohio's SIP for the Establishment of Interim Progress for the Fine Particle National Ambient Air Quality and early fine particulate (PM2.5) transportation conformity emission budgets.

  17. 77 FR 24952 - Agency Information Collection Activities; Proposed Collection; Comment Request; Regional Haze...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ....regulations.gov Web site is an ``anonymous access'' system, which means the EPA will not know your identity or... and the states will be shifting their focus to development of interim progress reports required by the...

  18. Vibratory roller evaluation study : interim report No. 1.

    DOT National Transportation Integrated Search

    1974-08-01

    The Louisiana Department of Highways has in progress a two phase program to evaluate the use of vibratory rollers in the compaction of asphaltic concrete pavements. Phase one on the first construction project is now complete with eight different vibr...

  19. Health care fraud and abuse data collection program: technical revisions to healthcare integrity and protection data bank data collection activities. Interim final rule with comment period.

    PubMed

    2004-06-17

    The rule makes technical changes to the Healthcare Integrity and Protection Data Bank (HIPDB) data collection reporting requirements set forth in 45 CFR part 61 by clarifying the types of personal numeric identifiers that may be reported to the data bank in connection with adverse actions. Specifically, the rule clarifies that in lieu of a Social Security Number (SSN), an individual taxpayer identification number (ITIN) may be reported to the data bank when, in those limited situations, an individual does not have an SSN.

  20. Improved survival with vemurafenib in melanoma with BRAF V600E mutation.

    PubMed

    Chapman, Paul B; Hauschild, Axel; Robert, Caroline; Haanen, John B; Ascierto, Paolo; Larkin, James; Dummer, Reinhard; Garbe, Claus; Testori, Alessandro; Maio, Michele; Hogg, David; Lorigan, Paul; Lebbe, Celeste; Jouary, Thomas; Schadendorf, Dirk; Ribas, Antoni; O'Day, Steven J; Sosman, Jeffrey A; Kirkwood, John M; Eggermont, Alexander M M; Dreno, Brigitte; Nolop, Keith; Li, Jiang; Nelson, Betty; Hou, Jeannie; Lee, Richard J; Flaherty, Keith T; McArthur, Grant A

    2011-06-30

    Phase 1 and 2 clinical trials of the BRAF kinase inhibitor vemurafenib (PLX4032) have shown response rates of more than 50% in patients with metastatic melanoma with the BRAF V600E mutation. We conducted a phase 3 randomized clinical trial comparing vemurafenib with dacarbazine in 675 patients with previously untreated, metastatic melanoma with the BRAF V600E mutation. Patients were randomly assigned to receive either vemurafenib (960 mg orally twice daily) or dacarbazine (1000 mg per square meter of body-surface area intravenously every 3 weeks). Coprimary end points were rates of overall and progression-free survival. Secondary end points included the response rate, response duration, and safety. A final analysis was planned after 196 deaths and an interim analysis after 98 deaths. At 6 months, overall survival was 84% (95% confidence interval [CI], 78 to 89) in the vemurafenib group and 64% (95% CI, 56 to 73) in the dacarbazine group. In the interim analysis for overall survival and final analysis for progression-free survival, vemurafenib was associated with a relative reduction of 63% in the risk of death and of 74% in the risk of either death or disease progression, as compared with dacarbazine (P<0.001 for both comparisons). After review of the interim analysis by an independent data and safety monitoring board, crossover from dacarbazine to vemurafenib was recommended. Response rates were 48% for vemurafenib and 5% for dacarbazine. Common adverse events associated with vemurafenib were arthralgia, rash, fatigue, alopecia, keratoacanthoma or squamous-cell carcinoma, photosensitivity, nausea, and diarrhea; 38% of patients required dose modification because of toxic effects. Vemurafenib produced improved rates of overall and progression-free survival in patients with previously untreated melanoma with the BRAF V600E mutation. (Funded by Hoffmann-La Roche; BRIM-3 ClinicalTrials.gov number, NCT01006980.).

  1. Global Spent Fuel Logistics Systems Study (GSFLS). Volume 2. GSFLS visit findings and evaluations. Interim report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1978-01-31

    This report is a part of the interim report documentation for the Global Spent Fuel Logistics System (GSFLS) study. This report describes a global framework that evaluates spent fuel disposition requirements, influencing factors and strategies. A broad sampling of foreign governmental officials, electric utility spokesmen and nuclear power industry officials responsible for GSFLS policies, plans and programs were surveyed as to their views with respect to national and international GSFLS related considerations. The results of these GSFLS visit findings are presented herein. These findings were then evaluated in terms of technical, institutional and legal/regulatory implications. The GSFLS evaluations, in conjunctionmore » with perceived US spent fuel objectives, formed the basis for selecting a set of GSFLS strategies which are reported herein.« less

  2. Multifunctional Nanotechnology Research

    DTIC Science & Technology

    2016-03-01

    MULTIFUNCTIONAL NANOTECHNOLOGY RESEARCH MARCH 2016 INTERIM TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED STINFO COPY AIR...REPORT 3. DATES COVERED (From - To) JAN 2015 – JAN 2016 4. TITLE AND SUBTITLE MULTIFUNCTIONAL NANOTECHNOLOGY RESEARCH 5a. CONTRACT NUMBER IN-HOUSE...H. Yoon, and C. S. Hwang, “Electrically configurable electroforming and bipolar resistive switching in Pt/TiO2/Pt structures.,” Nanotechnology , vol

  3. A Real-Time Systems Symposium Preprint.

    DTIC Science & Technology

    1983-09-01

    Real - Time Systems Symposium Preprint Interim Tech...estimate of the occurence of the error. Unclassii ledSECUqITY CLASSIF’ICA T" NO MI*IA If’ inDI /’rrd erter for~~ble. ’Corrputnqg A REAL - TIME SYSTEMS SYMPOSIUM...ABSTRACT This technical report contains a preprint of a paper accepted for presentation at the REAL - TIME SYSTEMS SYMPOSIUM, Arlington,

  4. Technical Operations (TOPS) IV Task Order 0003: Responsive Interface for Transport Tuning (RITT)

    DTIC Science & Technology

    2016-05-29

    on the further development of artificial hair sensors (AHS) featuring a responsive carbon nanotube (CNT) array to serve as a piezoresistive element...under separate cover, as AFRL Interim Report AFRL-RX-WP-TR-2016-0071 dated 30 October 2015. 15. SUBJECT TERMS artificial hair sensor, carbon... Hair Sensors: Fabrication and Model Parameterization .......................... 4 3.1.1 Introduction

  5. Examination of Multi-Core Architectures

    DTIC Science & Technology

    2010-11-01

    NOVEMBER 2010 2. REPORT TYPE Interim Technical Report 3. DATES COVERED (From - To) February 2010 – July 2010 4 . TITLE AND SUBTITLE EXAMINATION OF...STATEMENT 1 2.0 BACKGROUND 1 3.0 ARCHITECTURE CHARACTERISTICS 3 3.1 NVIDIA Tesla 3 3.2 TILE64 4 ...1 Tesla Architecture 3 2 TILE64 Architecture 4 3 Single Tile Architecture 4 4 STI Cell Broadband Engine

  6. General Cognitive Ability Predicts Job Performance. Interim Technical Paper for Period November 1990 - November 1991.

    ERIC Educational Resources Information Center

    Ree, Malcolm James; And Others

    A study investigated the roles of general ability and specific abilities as predictors of several job performance criteria for Air Force enlistees in eight jobs. Subjects were 1,545 Air Force enlistees entering from 1984 through 1988 who had tested with the Armed Services Vocational Aptitude Battery (ASVAB) parallel forms 11, 12, or 13. Subjects…

  7. Development of a Curriculum to Meet Changing Manpower Needs of the Computer and Business Machine Industries; Interim Developments. Final Report.

    ERIC Educational Resources Information Center

    Lescarbeau, Roland F.; And Others

    This suggested curriculum guide represents the consensus of opinion by the representatives of seven schools comprising the Technical Education Consortium, with advice of industrial experts concerning the essential educational needs of the technicians they would employ. It will serve as a guide to schools planning to institute a program applicable…

  8. 2016 Lake Michigan Lake Trout Working Group Report

    USGS Publications Warehouse

    Madenjian, Charles P.; Breidert, Brian; Boyarski, David; Bronte, Charles R.; Dickinson, Ben; Donner, Kevin; Ebener, Mark P.; Gordon, Roger; Hanson, Dale; Holey, Mark; Janssen, John; Jonas, Jory; Kornis, Matthew; Olsen, Erik; Robillard, Steve; Treska, Ted; Weldon, Barry; Wright, Greg D.

    2017-01-01

    This report provides a review on the progression of lake trout rehabilitation towards meeting the Salmonine Fish Community Objectives (FCOs) for Lake Michigan (Eshenroder et. al. 1995) and the interim goal and evaluation objectives articulated in A Fisheries Management Implementation Strategy for the Rehabilitation of Lake Trout in Lake Michigan (Dexter et al. 2011); we also include data describing lake trout stocking and mortality to portray the present state of progress towards lake trout rehabilitation.

  9. National Assessment of Title I: Interim Report. Volume II: Closing the Reading Gap: First Year Findings from a Randomized Trial of Four Reading Interventions for Striving Readers

    ERIC Educational Resources Information Center

    Torgesen, Joseph; Myers, David; Schirm, Allen; Stuart, Elizabeth; Vartivarian, Sonya; Mansfield, Wendy; Stancavage, Fran; Durno, Donna; Javorsky, Rosanne; Haan, Cinthia

    2006-01-01

    According to the National Assessment of Educational Progress, nearly 4 in 10 fourth graders read below the basic level. These literacy problems get worse as students advance through school and are exposed to progressively more complex concepts and courses. The purpose of this study was to assess the effectiveness of four remedial reading programs…

  10. Progression-free survival of early interim PET-positive patients with advanced stage Hodgkin's lymphoma treated with BEACOPPescalated alone or in combination with rituximab (HD18): an open-label, international, randomised phase 3 study by the German Hodgkin Study Group.

    PubMed

    Borchmann, Peter; Haverkamp, Heinz; Lohri, Andreas; Mey, Ulrich; Kreissl, Stefanie; Greil, Richard; Markova, Jana; Feuring-Buske, Michaela; Meissner, Julia; Dührsen, Ulrich; Ostermann, Helmut; Keller, Ulrich; Maschmeyer, Georg; Kuhnert, Georg; Dietlein, Markus; Kobe, Carsten; Eich, Hans; Baues, Christian; Stein, Harald; Fuchs, Michael; Diehl, Volker; Engert, Andreas

    2017-04-01

    Advanced stage Hodgkin's lymphoma represents a heterogeneous group of patients with different risk profiles. Data suggests that interim PET assessment during chemotherapy is superior to baseline international prognostic scoring in terms of predicting long-term treatment outcome in patients with Hodgkin's lymphoma. We therefore hypothesised that early interim PET-imaging after two courses of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) might be suitable for guiding treatment in patients with advanced stage Hodgkin's lymphoma. We aimed to assess whether intensifying standard chemotherapy (BEACOPP escalated ) by adding rituximab would improve progression-free survival in patients with positive PET after two courses of chemotherapy. In this open-label, international, randomised, phase 3 study, we recruited patients aged 18-60 years with newly diagnosed, advanced stage Hodgkin's lymphoma from 160 hospitals and 77 private practices in Germany, Switzerland, Austria, the Netherlands, and the Czech Republic. Interim PET-imaging was done after two cycles of BEACOPP escalated and centrally assessed by an expert panel. Patients with a positive PET after 2 cycles of BEACOPP escalated chemotherapy (PET-2) were randomly assigned (1:1) to receive six additional courses of either BEACOPP escalated (BEACOPP escalated group) or BEACOPP escalated plus rituximab (R-BEACOPP escalated group). PET-2 was assessed using a 5-point scale with 18 FDG uptake higher than the mediastinal blood pool (corresponding to Deauville scale 3) defined as positive. BEACOPP escalated was given as previously described; rituximab was given intravenously at a dose of 375 mg/m 2 (maximum total dose 700 mg), the first administration starting 24 h before starting the fourth cycle of BEACOPP escalated (day 0 and day 3 in cycle 4, day 1 in cycles 5-8). Randomisation was done centrally and used the minimisation method including a random component, stratified according to centre, age, stage, international prognostic score, and sex. The primary efficacy endpoint was 5 year progression-free survival, analysed in the intention-to-treat population. We are reporting this second planned interim analysis as the final report of the trial. The trial is registered with ClinicalTrials.gov, number NCT00515554. Between May 14, 2008, and May 31, 2011, we enrolled 1100 patients. 440 patients had a positive PET-2 and were randomly assigned to either the BEACOPP escalated group (n=220) or the R-BEACOPP escalated group (n=220). With a median follow-up of 33 months (IQR 25-42) for progression-free survival, estimated 3 year progression-free survival was 91·4% (95% CI 87·0-95·7) for patients in the BEACOPP escalated group and 93·0% (89·4-96·6) for those in the R-BEACOPP escalated group (difference 1·6%, 95% CI -4·0 to 7·3; log rank p=0·99). Common grade 3-4 adverse events were leucopenia (207 [95%] of 218 patients in the BEACOPP escalated group vs 211 [96%] of 220 patients in the R-BEACOPP escalated group), and severe infections (51 [23%] vs 43 [20%] patients). Based on a futility analysis, the independent data monitoring committee recommended publication of this second planned interim analysis as the final result. Six (3%) of 219 patients in the BEACOPP escalated group and ten (5%) of 220 in the R-BEACOPP escalated group died; fatal treatment-related toxic effects occurred in one (<1%) patient in the BEACOPP escalated group and three (1%) in the R-BEACOPP escalated group, all of them due to infection. The addition of rituximab to BEACOPP escalated did not improve the progression-free survival of PET-2 positive patients with advanced stage Hodgkin's lymphoma. However, progression-free survival for PET-2 positive patients was much better than expected, exceeding even the outcome of PET-2-unselected patients in the previous HD15 trial. Thus, PET-2 cannot identify patients at high-risk for treatment failure in the context of the very effective German Hodgkin Study Group standard treatment for advanced stage Hodgkin's lymphoma. Deutsche Krebshilfe; Swiss State Secretariat for Education, Research and Innovation (SERI); and Roche Pharma. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Proficiency Guidance on New State Summative Assessments from NWEA

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2015

    2015-01-01

    Measures of Academic Progress® (MAP®) computer adaptive interim assessments serve many purposes, from informing instruction to identifying students for intervention to projecting proficiency on state accountability assessments. To make sure its flagship product does the latter, Northwest Evaluation Association™ (NWEA™) routinely conducts studies…

  12. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

  13. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

  14. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

  15. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

  16. 40 CFR 52.134 - Compliance schedules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... beyond July 31, 1975, shall apply any reasonable interim measures of control designed to reduce the... progress shall include, but not be limited to: Submittal of the final control plan to the Administrator... of component parts to accomplish emission control equipment or process modification; completion of...

  17. Evaluation of the healthy schools program: Part I. Interim progress.

    PubMed

    Beam, Margaret; Ehrlich, Ginny; Donze Black, Jessica; Block, Audrey; Leviton, Laura C

    2012-01-01

    Federal and state policies identify schools as a setting to prevent childhood obesity, but schools need better health-promoting strategies. The objective of this study was to evaluate interim progress in schools receiving hands-on training from the Healthy Schools Program, the nation's largest school-based program aimed at preventing childhood obesity. The 4-year program targets schools with predominantly low-income, African American, or Hispanic students. In 2010 we assessed schools that enrolled in the 2007-2008 and 2008-2009 school years. School representatives completed an inventory of 8 content areas: policy and systems, school meals, competitive foods and beverages, health education, physical education, physical activity outside of physical education, before- and after-school programs, and school employee wellness. Schools' baseline inventory was compared by t test with the most recent inventory available. Schools made significant changes in all content areas, and effect sizes were moderate to large. Participating schools improved environmental policies and practices to prevent childhood obesity. The program is a resource to implement recent federal and state policies.

  18. The 5 Habits of Effective PLCs

    ERIC Educational Resources Information Center

    Easton, Lois Brown

    2015-01-01

    This article describes the knowledge and skills that professional learning community members need to create a habit out of their desire. Habits serve educators as signposts of progress toward achieving their desires. They are interim indicators of a professional learning community's success. Ultimately, of course, professional learning communities…

  19. Predicting analysis time in events-driven clinical trials using accumulating time-to-event surrogate information.

    PubMed

    Wang, Jianming; Ke, Chunlei; Yu, Zhinuan; Fu, Lei; Dornseif, Bruce

    2016-05-01

    For clinical trials with time-to-event endpoints, predicting the accrual of the events of interest with precision is critical in determining the timing of interim and final analyses. For example, overall survival (OS) is often chosen as the primary efficacy endpoint in oncology studies, with planned interim and final analyses at a pre-specified number of deaths. Often, correlated surrogate information, such as time-to-progression (TTP) and progression-free survival, are also collected as secondary efficacy endpoints. It would be appealing to borrow strength from the surrogate information to improve the precision of the analysis time prediction. Currently available methods in the literature for predicting analysis timings do not consider utilizing the surrogate information. In this article, using OS and TTP as an example, a general parametric model for OS and TTP is proposed, with the assumption that disease progression could change the course of the overall survival. Progression-free survival, related both to OS and TTP, will be handled separately, as it can be derived from OS and TTP. The authors seek to develop a prediction procedure using a Bayesian method and provide detailed implementation strategies under certain assumptions. Simulations are performed to evaluate the performance of the proposed method. An application to a real study is also provided. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  20. Instructional System Design for Executive Orientation and Project Management Training Packages, Technical Memorandum No. 3. Interim Report. RF Project No. 3131-A1.

    ERIC Educational Resources Information Center

    Cook, Desmond L.; And Others

    This memorandum reports on the third phase, the design, of a four-phase project to design project management training materials for local educational agencies. The first section of the memorandum explains some considerations regarding management education and the organization of the report. Section 2 presents the design specifications for the…

  1. Army Systems Engineering Career Development Model

    DTIC Science & Technology

    2014-01-30

    Army Systems Engineering Career Development Model Interim Technical Report SERC -2014-TR-042-1 January 30, 2014 Principal Investigators Dr. Val...Gavito, Stevens Institute of Technology Dr. Michael Pennotti, Stevens Institute of Technology Task Order 004, RT 104 Report No. SERC -2014-TR-042-1...Institute of Technology 8. PERFORMING ORGANIZATION REPORT NUMBER SERC -2014-TR-042-1 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) DASD

  2. The Analytic Onion: Examining Training Issues from Different Levels of Analysis. Interim Technical Paper for Period July 1989-June 1991.

    ERIC Educational Resources Information Center

    Lamb, Theodore A.; Chin, Keric B. O.

    This paper proposes a conceptual framework based on different levels of analysis using the metaphor of the layers of an onion to help organize and structure thinking on research issues concerning training. It discusses the core of the "analytic onion," the biological level, and seven levels of analysis that surround that core: the individual, the…

  3. The variable polarity plasma arc welding process: Its application to the Space Shuttle external tank

    NASA Technical Reports Server (NTRS)

    Nunes, A. C., Jr.; Bayless, O. E., Jr.; Jones, C. S., III; Munafo, A. P.; Wilson, W. A.

    1983-01-01

    The technical history of the variable polarity plasma arc (VPPA) welding process being introduced as a partial replacement for the gas shielded tungsten arc process in assembly welding of the space shuttle external tank is described. Interim results of the weld strength qualification studies, and plans for further work on the implementation of the VPPA process are included.

  4. Long-term storage facility for reactor compartments in Sayda Bay - German support for utilization of nuclear submarines in Russia

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wolff, Dietmar; Voelzke, Holger; Weber, Wolfgang

    2007-07-01

    The German-Russian project that is part of the G8 initiative on Global Partnership Against the Spread of Weapons and Materials of Mass Destruction focuses on the speedy construction of a land-based interim storage facility for nuclear submarine reactor compartments at Sayda Bay near Murmansk. This project includes the required infrastructure facilities for long-term storage of about 150 reactor compartments for a period of about 70 years. The interim storage facility is a precondition for effective activities of decommissioning and dismantlement of almost all nuclear-powered submarines of the Russian Northern Fleet. The project also includes the establishment of a computer-assisted wastemore » monitoring system. In addition, the project involves clearing Sayda Bay of other shipwrecks of the Russian navy. On the German side the project is carried out by the Energiewerke Nord GmbH (EWN) on behalf of the Federal Ministry of Economics and Labour (BMWi). On the Russian side the Kurchatov Institute holds the project management of the long-term interim storage facility in Sayda Bay, whilst the Nerpa Shipyard, which is about 25 km away from the storage facility, is dismantling the submarines and preparing the reactor compartments for long-term interim storage. The technical monitoring of the German part of this project, being implemented by BMWi, is the responsibility of the Federal Institute for Materials Research and Testing (BAM). This paper gives an overview of the German-Russian project and a brief description of solutions for nuclear submarine disposal in other countries. At Nerpa shipyard, being refurbished with logistic and technical support from Germany, the reactor compartments are sealed by welding, provided with biological shielding, subjected to surface treatment and conservation measures. Using floating docks, a tugboat tows the reactor compartments from Nerpa shipyard to the interim storage facility at Sayda Bay where they will be left on the on-shore concrete storage space to allow the radioactivity to decay. For transport of reactor compartments at the shipyard, at the dock and at the storage facility, hydraulic keel blocks, developed and supplied by German subcontractors, are used. In July 2006 the first stage of the reactor compartment storage facility was commissioned and the first seven reactor compartments have been delivered from Nerpa shipyard. Following transports of reactor compartments to the storage facility are expected in 2007. (authors)« less

  5. Corrective Action Glossary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-07-01

    The glossary of technical terms was prepared to facilitate the use of the Corrective Action Plan (CAP) issued by OSWER on November 14, 1986. The CAP presents model scopes of work for all phases of a corrective action program, including the RCRA Facility Investigation (RFI), Corrective Measures Study (CMS), Corrective Measures Implementation (CMI), and interim measures. The Corrective Action Glossary includes brief definitions of the technical terms used in the CAP and explains how they are used. In addition, expected ranges (where applicable) are provided. Parameters or terms not discussed in the CAP, but commonly associated with site investigations ormore » remediations are also included.« less

  6. Characterization of Atmospheric Aerosol Behavior and Climatic Effects by Analysis of SAGE 2 and Other Space, Air, and Ground Measurements

    NASA Technical Reports Server (NTRS)

    Livingston, John M.

    1999-01-01

    This report documents the research performed under NASA Ames Cooperative Agreement NCC 2-991, which covered the period 1 April 1997 through 31 March 1999. Previously, an interim technical report (Technical Report No. 1, 20 March 1998) summarized the work completed during the period 1 April 1997 through 31 March 1998. The objective of the proposed research was to advance our understanding of atmospheric aerosol behavior, aerosol-induced climatic effects, and the remote measurement and retrieval capabilities of spaceborne sensors such as SAGE II by combining and comparing data from these instruments and from airborne and ground-based instruments.

  7. Linking the ACT ASPIRE Assessments to NWEA MAP Assessments

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

  8. School, Work and Family Planning. Interim Impacts in Project Redirection.

    ERIC Educational Resources Information Center

    Polit, Denise F.; And Others

    Project Redirection was designed to help pregnant and parenting adolescents progress toward eventual self-sufficiency by linking them with community agencies and volunteers at four geographically and ethnically diverse sites in the United States. Distinctive features of the program include: (1) a broad scope of services including employability…

  9. Capabilities Roadmap Briefings to the National Research Council

    NASA Technical Reports Server (NTRS)

    2005-01-01

    High energy power and propulsion capability roadmap - general background and introduction. Advanced telescopes and observatories and scientific instruments and sensors capability roadmaps - general background and introduction. Space communications capability roadmap interim review. Robotic access to planetary surface capability roadmap. Human health and support systems capability roadmap progress review.

  10. Air traffic control : good progress on interim replacement for outage-plagued system, but risks can be further reduced

    DOT National Transportation Integrated Search

    1996-10-01

    Certain air traffic control(ATC) centers experienced a series of major outages, : some of which were caused by the Display Channel Complex or DCC-a mainframe : computer system that processes radar and other data into displayable images on : controlle...

  11. Consumption Taxes and Economic Efficiency with Idiosyncratic Wage Shocks

    ERIC Educational Resources Information Center

    Nishiyama, Shinichi; Smetters, Kent

    2005-01-01

    Fundamental tax reform is examined in an overlapping-generations model in which heterogeneous agents face idiosyncratic wage shocks and longevity uncertainty. A progressive income tax is replaced with a flat consumption tax. If idiosyncratic wage shocks are insurable (i.e., no risk), this reform improves (interim) efficiency, a result consistent…

  12. NASA Multidisciplinary Design and Analysis Fellowship Program

    NASA Technical Reports Server (NTRS)

    1995-01-01

    This report is a Year 1 interim report of the progress on the NASA multidisciplinary Design and Analysis Fellowship Program covering the period, January 1, 1995 through September 30, 1995. It summarizes progress in establishing the MDA Fellowship Program at Georgia Tech during the initial year. Progress in the advertisement of the program, recruiting results for the 1995-96 academic year, placement of the Fellows in industry during Summer 1995, program development at the M.S. and Ph.D. levels, and collaboration and dissemination of results are summarized in this report. Further details of the first year's progress will be included in the report from the Year 1 Workshop to be held at NASA Langley on December 7-8, 1995.

  13. Refractometry and Extinguishment/Burnback Testing of Pacific Air Forces AFFF

    DTIC Science & Technology

    2006-04-01

    AFRL-ML-TY-TR-2006-4536 REFRACTOMETRY AND EXTINGUISHMENT/ BURNBACK TESTING OF PACIFIC AIR FORCES AFFF Jennifer L. Kalberer...NAME OF RESPONSIBLE PERSON 19b. TELEPHONE NUMBER (Include area code) 31-04-2006 Interim Technical Report 01-08-2005 -- 30-09-2005 Refractometry and...AFRL) performed refractometry and extinguishment/burnback tests on samples of Ansulite and 3M aqueous film forming foam (AFFF) from an overseas air

  14. Electrical and Thermal Transport Property Studies of High-Temperature Thermoelectric Materials.

    DTIC Science & Technology

    1985-06-01

    THERMAL TRANSPORT PROPERTY STUDIES OF HIGH-TEMPERATURE THERMOELECTRIC MATERIALS: INTERIM TECHNICAL REPORT FOR THE PERIOD MAY 15, 1984 TO MAY 15, 1985 J. L...transport property data base has been expanded oy continued measurements in several systems under study, and a theoretical model for thermoelectric ...6.0 REFERENCES . . . . . . . . . . . . 6.1 APPENDIX A - THERMOELECTRIC PROPERTY DATA . . . . . . . A. I 1l FIGURES 3.1 Dimensionless Figure of Merit

  15. The role of interim 18F-FDG PET/CT in prediction of response to ipilimumab treatment in metastatic melanoma.

    PubMed

    Sachpekidis, Christos; Anwar, Hoda; Winkler, Julia; Kopp-Schneider, Annette; Larribere, Lionel; Haberkorn, Uwe; Hassel, Jessica C; Dimitrakopoulou-Strauss, Antonia

    2018-07-01

    The aim of the present study was to assess the value of interim 18 F-FDG PET/CT performed after the first two cycles of ipilimumab treatment in the prediction of the final clinical response to this type of immunotherapy. The study group comprised 41 patients with unresectable metastatic melanoma scheduled for ipilimumab therapy. Whole-body 18 F-FDG PET/CT was performed before the start of ipilimumab treatment (baseline PET/CT) and after the initial two cycles of ipilimumab treatment (interim PET/CT). Evaluation of patient response to treatment was based on the European Organization for Research and Treatment of Cancer (EORTC) 1999 criteria for PET as well as the recently proposed PET Response Evaluation Criteria for Immunotherapy (PERCIMT). The patients' best clinical response, assessed at a median of 21.4 months (range 6.3-41.9 months) was used as reference. According to their best clinical response, the patients were divided into two groups: those showing clinical benefit (CB) including stable disease, partial response and complete response (31 patients), and those showing no clinical benefit (no-CB including progressive disease (10 patients). According to the EORTC criteria, interim PET/CT demonstrated progressive metabolic disease (PMD) in 20 patients, stable metabolic disease (SMD) in 11 patients, partial metabolic response (PMR) in 8 patients, and complete metabolic response (CMR) in 2 patients. According to the PERCIMT, interim PET/CT demonstrated PMD in 9 patients, SMD in 24 patients, PMR in 6 patients and CMR in 2 patients. On the basis of the interim PET, the patients were divided in a similar manner to the division according to clinical response into those showing metabolic benefit (MB) including SMD, PMR and CMR, and those showing no metabolic benefit (no-MB) including PMD. According to this dichotomization, the EORTC criteria showed a sensitivity (correctly predicting CB) of 64.5%, a specificity (correctly predicting no-CB) of 90.0%, a positive predictive value (PPV) of 95.2%, a negative predictive value (NPV) of 45.0% and an accuracy of 70.7% in predicting best clinical response. The PERCIMT showed a sensitivity of 93.6%, a specificity of 70.0%, a PPV of 90.6%, a NPV of 77.8% and an accuracy of 87.8%. The McNemar test showed that the PERCIMT had a significantly higher sensitivity than EORTC criteria (p = 0.004), while there was no significant difference in specificity (p = 0.5). The agreement between the two sets of criteria was poor (McNemar test p = 0.001, and accordingly kappa = 0.46). The application of the recently proposed PERCIMT to interim 18 F-FDG PET/CT provides a more sensitive predictor of final clinical response to immunotherapy than the application of the EORTC criteria in patients with metastatic melanoma.

  16. 48 CFR 742.1170-4 - Progress reporting requirements and contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... progress. (b) Because the cognizant technical officer is the individual most familiar with the contractor's performance, the contractor must submit the progress reports directly to the cognizant technical officer. The cognizant technical officer must review the reports and advise the contracting officer, in writing, of any...

  17. Linking the Pennsylvania PSSA Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. Recently, NWEA completed a concordance study to connect the scales of the Pennsylvania System of School Assessment (PSSA) reading and math with those of the…

  18. Linking the Kentucky K-PREP Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

  19. Linking the Kansas KAP Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

  20. Linking the North Carolina EOG Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. Recently, NWEA completed a concordance study to connect the scales of the North Carolina End-of-Grade (EOG) English language arts (ELA) and math with those…

  1. Linking the PARCC Assessments to NWEA MAP Tests for Illinois

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

  2. Linking the Texas STAAR Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

  3. Linking the Nebraska NeSA Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

  4. Linking the Alaska AMP Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

  5. Linking the PARCC Assessments to NWEA MAP Tests for New Mexico

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

  6. Linking the Arizona AZMERIT Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. One important tool is the concordance table between MAP and state summative assessments. Concordance tables have been used for decades to relate scores on…

  7. The Responsiveness of Public Schools to Their Clientele. Milestone 1: Report of Progress.

    ERIC Educational Resources Information Center

    Zeigler, L. Harmon; And Others

    An analysis of the literature dealing with the responsiveness of public institutions to their clientele constitutes the main body of this interim project report. The analysts adopted Dahl and Lindblom's classification of political decision-making processes for summarizing the range of governing systems possible in public education. These four…

  8. Psychological and Educational Sequelae of Prematurity. Interim Report No. 11.

    ERIC Educational Resources Information Center

    Rubin, Rosalyn; And Others

    The longitudinal study assessed the psychological and educational sequelae of premature birth through the early elementary school years, to determine whether children born prematurely constitute a high risk population in terms of regular school progress. Subjects included 78 children with birth weights of 2500 grams or less, 78 children of normal…

  9. Linking the Virginia SOL Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. Recently, NWEA completed a concordance study to connect the scales of the Virginia Standards of Learning (SOL) reading and math tests with those of the MAP…

  10. Interim Service ISDN Satellite (ISIS) simulator development for advanced satellite designs and experiments

    NASA Technical Reports Server (NTRS)

    Pepin, Gerard R.

    1992-01-01

    The simulation development associated with the network models of both the Interim Service Integrated Services Digital Network (ISDN) Satellite (ISIS) and the Full Service ISDN Satellite (FSIS) architectures is documented. The ISIS Network Model design represents satellite systems like the Advanced Communications Technology Satellite (ACTS) orbiting switch. The FSIS architecture, the ultimate aim of this element of the Satellite Communications Applications Research (SCAR) Program, moves all control and switching functions on-board the next generation ISDN communications satellite. The technical and operational parameters for the advanced ISDN communications satellite design will be obtained from the simulation of ISIS and FSIS engineering software models for their major subsystems. Discrete event simulation experiments will be performed with these models using various traffic scenarios, design parameters, and operational procedures. The data from these simulations will be used to determine the engineering parameters for the advanced ISDN communications satellite.

  11. NASA/Navy Benchmarking Exchange (NNBE). Volume 1. Interim Report. Navy Submarine Program Safety Assurance

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The NASA/Navy Benchmarking Exchange (NNBE) was undertaken to identify practices and procedures and to share lessons learned in the Navy's submarine and NASA's human space flight programs. The NNBE focus is on safety and mission assurance policies, processes, accountability, and control measures. This report is an interim summary of activity conducted through October 2002, and it coincides with completion of the first phase of a two-phase fact-finding effort.In August 2002, a team was formed, co-chaired by senior representatives from the NASA Office of Safety and Mission Assurance and the NAVSEA 92Q Submarine Safety and Quality Assurance Division. The team closely examined the two elements of submarine safety (SUBSAFE) certification: (1) new design/construction (initial certification) and (2) maintenance and modernization (sustaining certification), with a focus on: (1) Management and Organization, (2) Safety Requirements (technical and administrative), (3) Implementation Processes, (4) Compliance Verification Processes, and (5) Certification Processes.

  12. 76 FR 78977 - Real Estate Settlement Procedures Act (Regulation X)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ...Title X of the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd-Frank Act) transferred rulemaking authority for a number of consumer financial protection laws from seven Federal agencies to the Bureau of Consumer Financial Protection (Bureau) as of July 21, 2011. The Bureau is in the process of republishing the regulations implementing those laws with technical and conforming changes to reflect the transfer of authority and certain other changes made by the Dodd-Frank Act. In light of the transfer of the Department of Housing and Urban Development's (HUD's) rulemaking authority for the Real Estate Settlement Procedures Act (RESPA) to the Bureau, the Bureau is publishing for public comment an interim final rule establishing a new Regulation X (Real Estate Settlement Procedures Act). This interim final rule does not impose any new substantive obligations on persons subject to the existing Regulation X, previously published by HUD.

  13. Combined Modality Treatment for PET-Positive Non-Hodgkin Lymphoma: Favorable Outcomes of Combined Modality Treatment for Patients With Non-Hodgkin Lymphoma and Positive Interim or Postchemotherapy FDG-PET

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Halasz, Lia M.; Jacene, Heather A.; Catalano, Paul J.

    2012-08-01

    Purpose: To evaluate outcomes of patients treated for aggressive non-Hodgkin lymphoma (NHL) with combined modality therapy based on [{sup 18}F]fluoro-2-deoxy-2-D-glucose positron emission tomography (FDG-PET) response. Methods and Materials: We studied 59 patients with aggressive NHL, who received chemotherapy and radiation therapy (RT) from 2001 to 2008. Among them, 83% of patients had stage I/II disease. Patients with B-cell lymphoma received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)-based chemotherapy, and 1 patient with anaplastic lymphoma kinase-negative anaplastic T-cell lymphoma received CHOP therapy. Interim and postchemotherapy FDG-PET or FDG-PET/computed tomography (CT) scans were performed for restaging. All patients received consolidated involved-field RT.more » Median RT dose was 36 Gy (range, 28.8-50 Gy). Progression-free survival (PFS) and local control (LC) rates were calculated with and without a negative interim or postchemotherapy FDG-PET scan. Results: Median follow-up was 46.5 months. Thirty-nine patients had negative FDG-PET results by the end of chemotherapy, including 12 patients who had a negative interim FDG-PET scan and no postchemotherapy PET. Twenty patients were FDG-PET-positive, including 7 patients with positive interim FDG-PET and no postchemotherapy FDG-PET scans. The 3-year actuarial PFS rates for patients with negative versus positive FDG-PET scans were 97% and 90%, respectively. The 3-year actuarial LC rates for patients with negative versus positive FDG-PET scans were 100% and 90%, respectively. Conclusions: Patients who had a positive interim or postchemotherapy FDG-PET had a PFS rate of 90% at 3 years after combined modality treatment, suggesting that a large proportion of these patients can be cured with consolidated RT.« less

  14. Data Analysis of GPM Constellation Satellites-IMERG and ERA-Interim precipitation products over West of Iran

    NASA Astrophysics Data System (ADS)

    Sharifi, Ehsan; Steinacker, Reinhold; Saghafian, Bahram

    2016-04-01

    Precipitation is a critical component of the Earth's hydrological cycle. The primary requirement in precipitation measurement is to know where and how much precipitation is falling at any given time. Especially in data sparse regions with insufficient radar coverage, satellite information can provide a spatial and temporal context. Nonetheless, evaluation of satellite precipitation is essential prior to operational use. This is why many previous studies are devoted to the validation of satellite estimation. Accurate quantitative precipitation estimation over mountainous basins is of great importance because of their susceptibility to hazards. In situ observations over mountainous areas are mostly limited, but currently available satellite precipitation products can potentially provide the precipitation estimation needed for meteorological and hydrological applications. One of the newest and blended methods that use multi-satellites and multi-sensors has been developed for estimating global precipitation. The considered data set known as Integrated Multi-satellitE Retrievals (IMERG) for GPM (Global Precipitation Measurement) is routinely produced by the GPM constellation satellites. Moreover, recent efforts have been put into the improvement of the precipitation products derived from reanalysis systems, which has led to significant progress. One of the best and a worldwide used model is developed by the European Centre for Medium Range Weather Forecasts (ECMWF). They have produced global reanalysis daily precipitation, known as ERA-Interim. This study has evaluated one year of precipitation data from the GPM-IMERG and ERA-Interim reanalysis daily time series over West of Iran. IMERG and ERA-Interim yield underestimate the observed values while IMERG underestimated slightly and performed better when precipitation is greater than 10mm. Furthermore, with respect to evaluation of probability of detection (POD), threat score (TS), false alarm ratio (FAR) and probability of false detection (POFD) IMERG yields a better value of POD, TS, FAR and POFD in comparison to era-Interim. Overall, ERA-Interim product produced fewer robust results when compared to IMERG.

  15. Education, Technical Progress, and Economic Growth: The Case of Taiwan.

    ERIC Educational Resources Information Center

    Lin, T.-C.

    2003-01-01

    Investigates the effect of education and the role of technical progress on economic growth in Taiwan from 1965-2000. Finds that education has a positive and significant effect on growth, but the role of technical progress does not appear to be extraordinarily important. Furthermore, no markedly significant relationships exist between capital and…

  16. FAA (Federal Aviation Administration) Aviation Forecasts: Fiscal Years 1989-2000

    DTIC Science & Technology

    1989-03-01

    predict interim business cycles. FAA FORECAST ECONOMIC ASSUMPTIONS FISCAL YEARS 1989 - 2000 HISTORICAL FORECAST PERCENT AVERAGE ANNUAL GROWTH ECONOMIC ...During previous economic cycles, changes in the general aviation industry have generally paralleled changes in business activity. Empirical results have...FiFAA-APO 89- MARCH 198 US eat e T of 0rrs orci Fedra Aviatio Ad instato 0 NA II I1 Technical Report Documentation Page 1 ReotN.2. Government

  17. Development of Titanium Alloy Casting Technology

    DTIC Science & Technology

    1976-08-01

    reduction in melting temperatures (Table 8). (3 0 )Smeltzer, C.E., and Compton, W.A., "Titanium Braze System for High Temperature Applications", First...Compton, W. A., "Titanium Braze System for High Temperature Applications," First Interim Technical Report, Solar Division of International Harvester Co...Microstructures of the Phase 1I Ti-13Cu Alloy (Meat 2LO56) Showing the Effect of Various Aging Treatments After High Temperature Annealing 113 xi

  18. Analysis of Commercially Available Firefighting Helmet and Boot Options for the Joint Firefighter Integrated Response Ensemble (JFIRE)

    DTIC Science & Technology

    2012-02-01

    AFRL-RX-TY-TR-2012-0022 ANALYSIS OF COMMERCIALLY AVAILABLE HELMET AND BOOT OPTIONS FOR THE JOINT FIREFIGHTER INTEGRATED RESPONSE ENSEMBLE...Interim Technical Report 01-SEP-2010 -- 31-JAN-2011 Analysis of Commercially Available Firefighting Helmet and Boot Options for the Joint Firefighter...ensemble. A requirements correlation matrix was generated and sent to industry detailing objective and threshold measurements for both the helmet

  19. Final Report: Characterization of Canister Mockup Weld Residual Stresses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Enos, David; Bryan, Charles R.

    2016-12-01

    Stress corrosion cracking (SCC) of interim storage containers has been indicated as a high priority data gap by the Department of Energy (DOE) (Hanson et al., 2012), the Electric Power Research Institute (EPRI, 2011), the Nuclear Waste Technical Review Board (NWTRB, 2010a), and the Nuclear Regulatory Commission (NRC, 2012a, 2012b). Uncertainties exist in terms of the environmental conditions that prevail on the surface of the storage containers, the stress state within the container walls associated both with weldments as well as within the base metal itself, and the electrochemical properties of the storage containers themselves. The goal of the workmore » described in this document is to determine the stress states that exists at various locations within a typical storage canister by evaluating the properties of a full-diameter cylindrical mockup of an interim storage canister. This mockup has been produced using the same manufacturing procedures as the majority of the fielded spent nuclear fuel interim storage canisters. This document describes the design and procurement of the mockup and the characterization of the stress state associated with various portions of the container. It also describes the cutting of the mockup into sections for further analyses, and a discussion of the potential impact of the results from the stress characterization effort.« less

  20. Webinar May 17: Fuel Cell Electric Bus Progress Toward Meeting Technical

    Science.gov Websites

    Targets | News | NREL Webinar May 17: Fuel Cell Electric Bus Progress toward Meeting Technical Targets Webinar May 17: Fuel Cell Electric Bus Progress toward Meeting Technical Targets May 14, 2018 The U.S. Department of Energy's (DOE's) Fuel Cell Technologies Office will present a live webinar titled

  1. Linking the New York State NYSTP Assessments to NWEA MAP Tests

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. Recently, NWEA completed a concordance study to connect the scales of the New York State Testing Program (NYSTP) reading and math with those of the MAP…

  2. Job Training for the Homeless: Report on Demonstration's First Year. Research and Evaluation Report Series 91-F.

    ERIC Educational Resources Information Center

    Bailis, Lawrence N.; And Others

    An interim evaluation analyzed the first year of operation of the Job Training for the Homeless Demonstration Program (JTHDP). Data were collected from quarterly progress reports and evaluation reports submitted by 32 local JTHDP projects. The projects exceeded planned levels of clients served and achieved other positive outcomes, including…

  3. An Evaluation of ESEA Title III Projects, Fiscal Year 1972. Interim Report.

    ERIC Educational Resources Information Center

    Wilson, Jerusa; And Others

    This report contains descriptions and progress of five projects in the District of Columbia partially or wholly funded by ESEA Title III: (1) The Columbia Road Preschool Pilot Project, a second-year experimental effort designed to serve as a model school providing an experimental setting for early childhood educational programs; (2) The Montessori…

  4. A Computerized Classroom Language Management and Recording System for Deaf and Hard of Hearing Children.

    ERIC Educational Resources Information Center

    Bornstein, Harry; Casella, Vicki

    This interim report describes the development of a networked computerized classroom language management and recording system to assist teachers of children who are deaf or hard-of-hearing. The system will provide storage and access capability for such information as changes in instruction, language learning progress, modifications in communication…

  5. DEBLICOM: Deaf-Blind Communication and Control Systems. Interim Progress Report, August 1974-August 1975.

    ERIC Educational Resources Information Center

    Kafafian, Haig

    Presented is a report on the work of Cybernetics Research Institute (CRI) investigators on the development of deaf-blind communication and control systems (DEBLICOM). Described in Part One is one embodiment of DEBLICOM designed and built by CRI engineers. Reported in Part Two are experimental procedures and human factors considerations of…

  6. Institute for Developmental Studies Interim Progress Report. Part II: Research and Evaluation.

    ERIC Educational Resources Information Center

    Deutsch, Martin; And Others

    The Institute for Developmental Studies (IDS) is engaged in research aimed at specifying what the academic handicaps of deprived children are, what causes these handicaps, and what can be done to overcome them. This IDS report on their research and evaluation program is divided into two sections. The first, "Summaries of Basic Research, Applied…

  7. 78 FR 37698 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-67; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ............ Contracting with 2013-010 Morgan. Women-owned Small Business Concerns (Interim). VIII Deletion of Report 2013... panel, consists of senior-level DoD officials from across DoD working to review progress made by DoD to... ensure that CORs understand their duties and responsibilities to survey contractor performance. This...

  8. Review of the transport of selected radionuclides in the interim risk assessment for the Radioactive Waste Management Complex, Waste Area Group 7 Operable Unit 7-13/14, Idaho National Engineering and Environmental Laboratory, Idaho

    USGS Publications Warehouse

    Rousseau, Joseph P.; Landa, Edward R.; Nimmo, John R.; Cecil, L. DeWayne; Knobel, LeRoy L.; Glynn, Pierre D.; Kwicklis, Edward M.; Curtis, Gary P.; Stollenwerk, Kenneth G.; Anderson, Steven R.; Bartholomay, Roy C.; Bossong, Clifford R.; Orr, Brennon R.

    2005-01-01

    The U.S. Department of Energy (DOE) requested that the U.S. Geological Survey conduct an independent technical review of the Interim Risk Assessment (IRA) and Contaminant Screening for the Waste Area Group 7 (WAG-7) Remedial Investigation, the draft Addendum to the Work Plan for Operable Unit 7-13/14 WAG-7 comprehensive Remedial Investigation and Feasibility Study (RI/FS), and supporting documents that were prepared by Lockheed Martin Idaho Technologies, Inc. The purpose of the technical review was to assess the data and geotechnical approaches that were used to estimate future risks associated with the release of the actinides americium, uranium, neptunium, and plutonium to the Snake River Plain aquifer from wastes buried in pits and trenches at the Subsurface Disposal Area (SDA). The SDA is located at the Radioactive Waste Management Complex in southeastern Idaho within the boundaries of the Idaho National Engineering and Environmental Laboratory. Radionuclides have been buried in pits and trenches at the SDA since 1957 and 1952, respectively. Burial of transuranic wastes was discontinued in 1982. The five specific tasks associated with this review were defined in a ?Proposed Scope of Work? prepared by the DOE, and a follow-up workshop held in June 1998. The specific tasks were (1) to review the radionuclide sampling data to determine how reliable and significant are the reported radionuclide detections and how reliable is the ongoing sampling program, (2) to assess the physical and chemical processes that logically can be invoked to explain true detections, (3) to determine if distribution coefficients that were used in the IRA are reliable and if they have been applied properly, (4) to determine if transport model predictions are technically sound, and (5) to identify issues needing resolution to determine technical adequacy of the risk assessment analysis, and what additional work is required to resolve those issues.

  9. SNF Interim Storage Canister Corrosion and Surface Environment Investigations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bryan, Charles R.; Enos, David G.

    2015-09-01

    This progress report describes work being done at Sandia National Laboratories (SNL) to assess the localized corrosion performance of container/cask materials used in the interim storage of spent nuclear fuel (SNF). Of particular concern is stress corrosion cracking (SCC), by which a through-wall crack could potentially form in a canister outer wall over time intervals that are shorter than possible dry storage times. In order for SCC to occur, three criteria must be met. A corrosive environment must be present on the canister surface, the metal must susceptible to SCC, and sufficient tensile stress to support SCC must be presentmore » through the entire thickness of the canister wall. SNL is currently evaluating the potential for each of these criteria to be met.« less

  10. 25 CFR 30.111 - When should the tribal governing body or school board request technical assistance?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... request technical assistance? 30.111 Section 30.111 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Technical Assistance § 30.111 When should the tribal governing body or school board request technical assistance? In order to...

  11. Manufacturing Technology for Apparel Automation. Phases 1 and 2.

    DTIC Science & Technology

    1987-07-15

    Modularized Work Unit Groups . . . . . . . 12 i +,. :.Aooesston For :".. NTIS GR.AA1 ’- " "D T I C T A B Unannounced [] ~Justification i Availability...The monthly interim reports are summarized in this semiannual report. Activity to date has included work performed by Ms. Carol Carrere Dr. T. G. Clapp...Management. Provide, in accordance with paragraph 3.1 of the Statement of Work (SOW), North Carolina State University’s Technical Proposal, Manufacturing

  12. Summary of Federal Aviation Administration Responses to National Transportation Safety Board Safety Recommendations.

    DTIC Science & Technology

    1981-01-01

    NASA was already being incorporated by several equipment manufacturers in their own development plans. A-78-29. In the interim, amend 14 CFR to...not necessary. Research and development previously accomplished by the U.S. Army and by NASA was already being incorporated by several equipment...by industry., On July 12, our Bureau of Technology hosted a U.S. Army/FAA/ NASA meeting to brief FAA and NASA representatives, at the technical level

  13. Online Monitoring Technical Basis and Analysis Framework for Large Power Transformers; Interim Report for FY 2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nancy J. Lybeck; Vivek Agarwal; Binh T. Pham

    The Light Water Reactor Sustainability program at Idaho National Laboratory (INL) is actively conducting research to develop and demonstrate online monitoring (OLM) capabilities for active components in existing Nuclear Power Plants. A pilot project is currently underway to apply OLM to Generator Step-Up Transformers (GSUs) and Emergency Diesel Generators (EDGs). INL and the Electric Power Research Institute (EPRI) are working jointly to implement the pilot project. The EPRI Fleet-Wide Prognostic and Health Management (FW-PHM) Software Suite will be used to implement monitoring in conjunction with utility partners: the Shearon Harris Nuclear Generating Station (owned by Duke Energy for GSUs, andmore » Braidwood Generating Station (owned by Exelon Corporation) for EDGs. This report presents monitoring techniques, fault signatures, and diagnostic and prognostic models for GSUs. GSUs are main transformers that are directly connected to generators, stepping up the voltage from the generator output voltage to the highest transmission voltages for supplying electricity to the transmission grid. Technical experts from Shearon Harris are assisting INL and EPRI in identifying critical faults and defining fault signatures associated with each fault. The resulting diagnostic models will be implemented in the FW-PHM Software Suite and tested using data from Shearon-Harris. Parallel research on EDGs is being conducted, and will be reported in an interim report during the first quarter of fiscal year 2013.« less

  14. 25 CFR 30.110 - What is the process for requesting technical assistance to develop an alternative definition of AYP?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF THE INTERIOR EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Technical Assistance § 30.110 What is the process for requesting technical assistance to develop an alternative... 25 Indians 1 2011-04-01 2011-04-01 false What is the process for requesting technical assistance...

  15. 25 CFR 30.110 - What is the process for requesting technical assistance to develop an alternative definition of AYP?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the process for requesting technical assistance..., DEPARTMENT OF THE INTERIOR EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Technical Assistance § 30.110 What is the process for requesting technical assistance to develop an alternative...

  16. Annual Summary Report Calendar Year 2000 for the 100-HR-3, 100-KR-4, and 100-NR-2 Operable Units and Pump-and-Treat Operations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    G. B. Mitchem

    2001-08-22

    This annual progress and performance evaluation report discusses the groundwater remedial actions in the 100 Area, including the interim actions at the 100-HR-3 and 100-KR-4 Operable Units, and also discusses the expedited response action in the 100-NR-2 operable unit.

  17. National Home Start Evaluation Interim Report VI. Twelve-Month Program Issues, Outcomes and Costs.

    ERIC Educational Resources Information Center

    Goodrich, Nancy; And Others

    This report assesses the progress of the six summative Home Start projects as evaluation families completed their first twelve months of enrollment. Home Start, a federally-funded 3-year (1972-1975) home-based demonstration program for low-income families with 3- to 5-year-old children was designed to enhance a mother's skills in dealing with her…

  18. ABE Phase III: Progress and Problems. September 1, 1969-April 1, 1970.

    ERIC Educational Resources Information Center

    Southwestern Cooperative Educational Lab., Albuquerque, NM.

    Interim information concerning the ABE III grants is provided in the three parts of this report. Part 1 (outline) describes the goals and objectives of each component; Part 2 describes accomplishments and problems to date; and Part 3 deals with coordination and supervision activities undertaken by the Lab. The components of the program are: (1)…

  19. Some Specifications for an Undergraduate Course in Digital Subsystems. An Interim Report of the Cosine Committee.

    ERIC Educational Resources Information Center

    Commission on Engineering Education, Washington, DC.

    This report describes an undergraduate course in digital subsystems. The course is divided into two major parts. Part I is entitled Electronic Circuits and Functional Units. The material in this part of the course proceeds from simple understandings of circuits to the progressively more complex functional units. Early emphasis is placed on basic…

  20. MFTF-. cap alpha. + T progress report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nelson, W.D.

    1985-04-01

    Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-..cap alpha..+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; theymore » will be supplied as the design study proceeds. As described in this report, MFTF-..cap alpha..+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m/sup 2/ (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components.« less

  1. Parallelization of Rocket Engine Simulator Software (P.R.E.S.S.)

    NASA Technical Reports Server (NTRS)

    Cezzar, Ruknet

    1999-01-01

    Parallelization of Rocket Engine System Software (PRESS) project is part of a collaborative effort with Southern University at Baton Rouge (SUBR), University of West Florida (UWF), and Jackson State University (JSU). The project has started on October 19, 1995, and after a three-year period corresponding to project phases and fiscal-year funding by NASA Lewis Research Center (now Glenn Research Center), has ended on October 18, 1998. The one-year no-cost extension period was granted on June 7, 1998, until October 19, 1999. The aim of this one year no-cost extension period was to carry out further research to complete the work and lay the groundwork for subsequent research in the area of aerospace engine design optimization software tools. The previous progress for the research has been reported in great detail in respective interim and final research progress reports, seven of them, in all. While the purpose of this report is to be a final summary and an valuative view of the entire work since the first year funding, the following is a quick recap of the most important sections of the interim report dated April 30, 1999.

  2. A two-stage patient enrichment adaptive design in phase II oncology trials.

    PubMed

    Song, James X

    2014-01-01

    Illustrated is the use of a patient enrichment adaptive design in a randomized phase II trial which allows the evaluation of treatment benefits by the biomarker expression level and makes interim adjustment according to the pre-specified rules. The design was applied to an actual phase II metastatic hepatocellular carcinoma (HCC) trial in which progression-free survival (PFS) in two biomarker-defined populations is evaluated at both interim and final analyses. As an extension, a short-term biomarker is used to predict the long-term PFS in a Bayesian model in order to improve the precision of hazard ratio (HR) estimate at the interim analysis. The characteristics of the extended design are examined in a number of scenarios via simulations. The recommended adaptive design is shown to be useful in a phase II setting. When a short-term maker which correlates with the long-term PFS is available, the design can be applied in smaller early phase trials in which PFS requires longer follow-up. In summary, the adaptive design offers flexibility in randomized phase II patient enrichment trials and should be considered in an overall personalized healthcare (PHC) strategy. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors.

    PubMed

    Strosberg, Jonathan; El-Haddad, Ghassan; Wolin, Edward; Hendifar, Andrew; Yao, James; Chasen, Beth; Mittra, Erik; Kunz, Pamela L; Kulke, Matthew H; Jacene, Heather; Bushnell, David; O'Dorisio, Thomas M; Baum, Richard P; Kulkarni, Harshad R; Caplin, Martyn; Lebtahi, Rachida; Hobday, Timothy; Delpassand, Ebrahim; Van Cutsem, Eric; Benson, Al; Srirajaskanthan, Rajaventhan; Pavel, Marianne; Mora, Jaime; Berlin, Jordan; Grande, Enrique; Reed, Nicholas; Seregni, Ettore; Öberg, Kjell; Lopera Sierra, Maribel; Santoro, Paola; Thevenet, Thomas; Erion, Jack L; Ruszniewski, Philippe; Kwekkeboom, Dik; Krenning, Eric

    2017-01-12

    Patients with advanced midgut neuroendocrine tumors who have had disease progression during first-line somatostatin analogue therapy have limited therapeutic options. This randomized, controlled trial evaluated the efficacy and safety of lutetium-177 ( 177 Lu)-Dotatate in patients with advanced, progressive, somatostatin-receptor-positive midgut neuroendocrine tumors. We randomly assigned 229 patients who had well-differentiated, metastatic midgut neuroendocrine tumors to receive either 177 Lu-Dotatate (116 patients) at a dose of 7.4 GBq every 8 weeks (four intravenous infusions, plus best supportive care including octreotide long-acting repeatable [LAR] administered intramuscularly at a dose of 30 mg) ( 177 Lu-Dotatate group) or octreotide LAR alone (113 patients) administered intramuscularly at a dose of 60 mg every 4 weeks (control group). The primary end point was progression-free survival. Secondary end points included the objective response rate, overall survival, safety, and the side-effect profile. The final analysis of overall survival will be conducted in the future as specified in the protocol; a prespecified interim analysis of overall survival was conducted and is reported here. At the data-cutoff date for the primary analysis, the estimated rate of progression-free survival at month 20 was 65.2% (95% confidence interval [CI], 50.0 to 76.8) in the 177 Lu-Dotatate group and 10.8% (95% CI, 3.5 to 23.0) in the control group. The response rate was 18% in the 177 Lu-Dotatate group versus 3% in the control group (P<0.001). In the planned interim analysis of overall survival, 14 deaths occurred in the 177 Lu-Dotatate group and 26 in the control group (P=0.004). Grade 3 or 4 neutropenia, thrombocytopenia, and lymphopenia occurred in 1%, 2%, and 9%, respectively, of patients in the 177 Lu-Dotatate group as compared with no patients in the control group, with no evidence of renal toxic effects during the observed time frame. Treatment with 177 Lu-Dotatate resulted in markedly longer progression-free survival and a significantly higher response rate than high-dose octreotide LAR among patients with advanced midgut neuroendocrine tumors. Preliminary evidence of an overall survival benefit was seen in an interim analysis; confirmation will be required in the planned final analysis. Clinically significant myelosuppression occurred in less than 10% of patients in the 177 Lu-Dotatate group. (Funded by Advanced Accelerator Applications; NETTER-1 ClinicalTrials.gov number, NCT01578239 ; EudraCT number 2011-005049-11 .).

  4. Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma.

    PubMed

    Choueiri, Toni K; Escudier, Bernard; Powles, Thomas; Mainwaring, Paul N; Rini, Brian I; Donskov, Frede; Hammers, Hans; Hutson, Thomas E; Lee, Jae-Lyun; Peltola, Katriina; Roth, Bruce J; Bjarnason, Georg A; Géczi, Lajos; Keam, Bhumsuk; Maroto, Pablo; Heng, Daniel Y C; Schmidinger, Manuela; Kantoff, Philip W; Borgman-Hagey, Anne; Hessel, Colin; Scheffold, Christian; Schwab, Gisela M; Tannir, Nizar M; Motzer, Robert J

    2015-11-05

    Cabozantinib is an oral, small-molecule tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR) as well as MET and AXL, each of which has been implicated in the pathobiology of metastatic renal-cell carcinoma or in the development of resistance to antiangiogenic drugs. This randomized, open-label, phase 3 trial evaluated the efficacy of cabozantinib, as compared with everolimus, in patients with renal-cell carcinoma that had progressed after VEGFR-targeted therapy. We randomly assigned 658 patients to receive cabozantinib at a dose of 60 mg daily or everolimus at a dose of 10 mg daily. The primary end point was progression-free survival. Secondary efficacy end points were overall survival and objective response rate. Median progression-free survival was 7.4 months with cabozantinib and 3.8 months with everolimus. The rate of progression or death was 42% lower with cabozantinib than with everolimus (hazard ratio, 0.58; 95% confidence interval [CI] 0.45 to 0.75; P<0.001). The objective response rate was 21% with cabozantinib and 5% with everolimus (P<0.001). A planned interim analysis showed that overall survival was longer with cabozantinib than with everolimus (hazard ratio for death, 0.67; 95% CI, 0.51 to 0.89; P=0.005) but did not cross the significance boundary for the interim analysis. Adverse events were managed with dose reductions; doses were reduced in 60% of the patients who received cabozantinib and in 25% of those who received everolimus. Discontinuation of study treatment owing to adverse events occurred in 9% of the patients who received cabozantinib and in 10% of those who received everolimus. Progression-free survival was longer with cabozantinib than with everolimus among patients with renal-cell carcinoma that had progressed after VEGFR-targeted therapy. (Funded by Exelixis; METEOR ClinicalTrials.gov number, NCT01865747.).

  5. 14 CFR 1274.701 - Suspension or termination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agreement if the recipient is not making anticipated technical progress, if the recipient materially changes...) Similarly, the recipient may terminate the agreement if, for example, technical progress is not being made, if the commercial recipient shifts its technical emphasis, or if other technological advances have...

  6. 14 CFR 1274.701 - Suspension or termination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agreement if the recipient is not making anticipated technical progress, if the recipient materially changes...) Similarly, the recipient may terminate the agreement if, for example, technical progress is not being made, if the commercial recipient shifts its technical emphasis, or if other technological advances have...

  7. Applications of Piezoelectric and Pyroelectric Thin Films: Opportunities for Langmuir-Blodgett Technology.

    DTIC Science & Technology

    1984-12-31

    LII IH"L 5 B 1.4 1111.6 MICROCOPY RESOLUTION TEST CHART SECURITY CLASSIFICATION OF THIS PAGE (MS’ien Dare Itere d) RED DSTUC ONS REPORT ...DOCUMENTATION PAGE BEFORE COMPLETIG FORM R NUMER . GOVT ACCESSION NO 5. RECIPIENT’S CATALOG iUMBER • TR-09 4. TITLE ( nd Subttle) S. TYPE OF REPORT A PERIOD...COVERELs Applications of Piezoelectric and Pyroelectric Technical Report -Interim Thin Films: Opportunities for Langmuir-Blodgett Technology 6. PERFORMING

  8. Tribology of Langmuir-Blodgett Films

    DTIC Science & Technology

    1992-03-01

    poly - meric systems and the use of Langmuir - Blodgett films as lubricants. An, 1473 ESWnoW’oP’-oVsS osOLe UNCLASSIFIED SECUlRTV CLASSIFICATIONi O r ThIS...N/A N/A 4. TITLE (and Subtitle) S. TyPE OF REPORT & PERIOD COVERED Tribology of Langmuir - Blodgett Films Interim Technical Report 6. PERFORMING ORO...Co . - e o If neceesea mnd Identily by block number) Tribology, Langmuir - Blodgett Films 2 AerNACT t 44 Pem.e s* I peminp and tdolvart by block niber

  9. COCHISE Observations of Argon Rydberg Emission from 2 to 16 Micrometers.

    DTIC Science & Technology

    1983-08-05

    8217natu 5 I RNDALL E. M YJOHN S . GARIG Branch Cief Division Director Qualified requestors may obtain additional copies from the Defense Technical... S . TYPE or REPORT a PERIOD COVERED COCHISE OBSERVATIONS OF ARGON Scientific. Interim. RYDBERG EMISSION FROM 2 TO 16 6. PERFORMING 0140. REPORT NUMMER...Comparisons of obd~erved and simulated spectra sliow that s i.ntial ",WIR emission (- 1~gmm Arises from Rydberg states ert~ DO .W-1473 fDITION OF I NOV 65

  10. Interim Report on Feasibility of Improving Recreation Access and Related Water and Land Management in the Buffalo Metropolitan Area, New York.

    DTIC Science & Technology

    1979-04-01

    Buffalo Metropolitan Study Area. One of these is the Lake Plain, a relatively flat and fertile agricultural belt which is wide in the northern portion of...events. Evidence of this can be seen in numerous highway relocations where secondary roads follow stream courses closely. A field reconnaissance was made...shrub and tree growth encroaching on the high water stream channel can be seen immediately upstream of the eroding area. The SCS has provided technical

  11. Impact of Learning Styles on Air Force Technical Training: Multiple and Linear Imagery in the Presentation of a Comparative Visual Location Task to Visual and Haptic Subjects. Interim Report for Period January 1977-January 1978.

    ERIC Educational Resources Information Center

    Ausburn, Floyd B.

    A U.S. Air Force study was designed to develop instruction based on the supplantation theory, in which tasks are performed (supplanted) for individuals who are unable to perform them due to their cognitive style. The study examined the effects of linear and multiple imagery in presenting a task requiring visual comparison and location to…

  12. The role and challenges of the food industry in addressing chronic disease

    PubMed Central

    2010-01-01

    Summary Increasingly, food companies play an important role in stemming the rising burden of nutrition-related chronic diseases. Concrete actions taken by these companies include global public commitments to address food reformulation, consumer information, responsible marketing, promotion of healthy lifestyles, and public-private partnerships. These actions are reviewed together with eleven specific PepsiCo goals and commitments that address products, the marketplace, and communities at large. Interim progress on these goals and commitments are discussed as well as constraints hampering faster progress. Further disease prevention depends on increasing implementation of private-public initiatives. PMID:20509876

  13. Progress in Scientific and Technical Communications, 1968 Annual Report.

    ERIC Educational Resources Information Center

    Federal Council for Science and Technology, Washington, DC. Committee on Scientific and Technical Information.

    This sixth annual report describes progress achieved by the Federal Government in improving the communication of scientific and technical information to support and enhance national science and technology. Included in the report are details regarding the scientific and technical activities of individual Federal Agencies, such as the Atomic Energy…

  14. Data Use "Multi-State" Spotlight: Using Data Fidelity Tools to Improve Data Quality. Transforming State Systems to Improve Outcomes for Children with Disabilities

    ERIC Educational Resources Information Center

    Ruedel, Kristin; Nelson, Gena; Bailey, Tessie

    2018-01-01

    To evaluate interim progress toward the State-identified Measurable Result (SIMR), states require access to high-quality data from local education agencies (LEAs) and early intervention service providers. In a review of 2017 Phase III State Systemic Improvement Plans (SSIP), 43 Part C states noted limitations or concerns related to data and…

  15. Randomized Clinical Trial Comparing Proton Beam Radiation Therapy with Transarterial Chemoembolization for Hepatocellular Carcinoma: Results of an Interim Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bush, David A., E-mail: dbush@llu.edu; Smith, Jason C.; Slater, Jerry D.

    2016-05-01

    Purpose: To describe results of a planned interim analysis of a prospective, randomized clinical trial developed to compare treatment outcomes among patients with newly diagnosed hepatocellular carcinoma (HCC). Methods and Materials: Eligible subjects had either clinical or pathologic diagnosis of HCC and met either Milan or San Francisco transplant criteria. Patients were randomly assigned to transarterial chemoembolization (TACE) or to proton beam radiation therapy. Patients randomized to TACE received at least 1 TACE with additional TACE for persistent disease. Proton beam radiation therapy was delivered to all areas of gross disease to a total dose of 70.2 Gy in 15 daily fractionsmore » over 3 weeks. The primary endpoint was progression-free survival, with secondary endpoints of overall survival, local tumor control, and treatment-related toxicities as represented by posttreatment days of hospitalization. Results: At the time of this analysis 69 subjects were available for analysis. Of these, 36 were randomized to TACE and 33 to proton. Total days of hospitalization within 30 days of TACE/proton was 166 and 24 days, respectively (P<.001). Ten TACE and 12 proton patients underwent liver transplantation after treatment. Viable tumor identified in the explanted livers after TACE/proton averaged 2.4 and 0.9 cm, respectively. Pathologic complete response after TACE/proton was 10%/25% (P=.38). The 2-year overall survival for all patients was 59%, with no difference between treatment groups. Median survival time was 30 months (95% confidence interval 20.7-39.3 months). There was a trend toward improved 2-year local tumor control (88% vs 45%, P=.06) and progression-free survival (48% vs 31%, P=.06) favoring the proton beam treatment group. Conclusions: This interim analysis indicates similar overall survival rates for proton beam radiation therapy and TACE. There is a trend toward improved local tumor control and progression-free survival with proton beam. There are significantly fewer hospitalization days after proton treatment, which may indicate reduced toxicity with proton beam therapy.« less

  16. 48 CFR 2452.242-71 - Contract management system.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., concise summary of technical progress made and the costs incurred for each task during the reporting... technical progress made for each task during the reporting period; and (B) Identifies problems, or potential... and progress reporting as described herein. (b) The contract management system shall consist of two...

  17. Evaluation of Hose in Hose Transfer Line Service Life for Hanfords Interim Stabilization Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    TORRES, T.D.

    RPP-6153, Engineering Task Plan for Hose-in-Hose Transfer System for the Interim Stabilization Program (Torres, 2000a), defines the programmatic goals, functional requirements, and technical criteria for the development and subsequent installation of waste transfer line equipment to support Hanford's Interim Stabilization Program. RPP-6028, Specification for Hose in Hose Transfer Lines for Hanford's Interim Stabilization Program (Torres, 2000b), has been issued to define the specific requirements for the design, manufacture, and verification of transfer line assemblies for specific waste transfer applications associated with Interim Stabilization. Included in RPP-6028 are tables defining the chemical constituents of concern to which transfer lines will bemore » exposed. Current Interim Stabilization Program planning forecasts that the at-grade transfer lines will be required to convey pumpable waste for as much as three years after commissioning, RPP-6028 Section 3.2.7. Performance Incentive Number ORP-05 requires that all the Single Shell Tanks be Interim Stabilized by September 30, 2003. The Tri-Party Agreement (TPA) milestone M-41-00, enforced by a federal consent decree, requires all the Single Shell Tanks to be Interim stabilized by September 30, 2004. By meeting the Performance Incentive the TPA milestone is met. Prudent engineering dictates that the equipment used to transfer waste have a life in excess of the forecasted operational time period, with some margin to allow for future adjustments to the planned schedule. This document evaluates the effective service life of the Hose-in-Hose Transfer Lines, based on information submitted by the manufacturer, published literature and calculations. The effective service life of transfer line assemblies is a function of several factors. Foremost among these are the hose material's resistance to the harmful effects of process fluid characteristics, ambient environmental conditions, exposure to ionizing radiation and the manufacturer's stated shelf life. In order to determine the transfer line service life this evaluation examines the certification of shelf life, the certification of chemical compatibility with waste, catalog information of ambient ratings and published literature on the effects of exposure to ionizing radiation on the mechanical properties of elastomeric materials. During initial hose procurements, the hose-in-hose transfer line vendor River Bend Hose Specialty (RBHS) submitted a letter, dated 6/8/00, which recommended the service and shelf life of the hose to be seven years. In submittals for later hose procurements, RBHS submitted a letter, dated 11/6/00, which recommended the service life of the hose to be three years. This submittal was followed by documentation, on 2/14/01, which submitted new storage requirements and restated the seven year shelf life. RBHS revised their original hose service life estimate to a more conservative three years due to concerns over the effects of chemicals in transferred waste. The above mentioned submittals from RBHS are the primary drivers of the three year service life limit established by this document.« less

  18. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma.

    PubMed

    Stewart, A Keith; Rajkumar, S Vincent; Dimopoulos, Meletios A; Masszi, Tamás; Špička, Ivan; Oriol, Albert; Hájek, Roman; Rosiñol, Laura; Siegel, David S; Mihaylov, Georgi G; Goranova-Marinova, Vesselina; Rajnics, Péter; Suvorov, Aleksandr; Niesvizky, Ruben; Jakubowiak, Andrzej J; San-Miguel, Jesus F; Ludwig, Heinz; Wang, Michael; Maisnar, Vladimír; Minarik, Jiri; Bensinger, William I; Mateos, Maria-Victoria; Ben-Yehuda, Dina; Kukreti, Vishal; Zojwalla, Naseem; Tonda, Margaret E; Yang, Xinqun; Xing, Biao; Moreau, Philippe; Palumbo, Antonio

    2015-01-08

    Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma. The combination of the proteasome inhibitor carfilzomib with lenalidomide and dexamethasone has shown efficacy in a phase 1 and 2 study in relapsed multiple myeloma. We randomly assigned 792 patients with relapsed multiple myeloma to carfilzomib with lenalidomide and dexamethasone (carfilzomib group) or lenalidomide and dexamethasone alone (control group). The primary end point was progression-free survival. Progression-free survival was significantly improved with carfilzomib (median, 26.3 months, vs. 17.6 months in the control group; hazard ratio for progression or death, 0.69; 95% confidence interval [CI], 0.57 to 0.83; P=0.0001). The median overall survival was not reached in either group at the interim analysis. The Kaplan-Meier 24-month overall survival rates were 73.3% and 65.0% in the carfilzomib and control groups, respectively (hazard ratio for death, 0.79; 95% CI, 0.63 to 0.99; P=0.04). The rates of overall response (partial response or better) were 87.1% and 66.7% in the carfilzomib and control groups, respectively (P<0.001; 31.8% and 9.3% of patients in the respective groups had a complete response or better; 14.1% and 4.3% had a stringent complete response). Adverse events of grade 3 or higher were reported in 83.7% and 80.7% of patients in the carfilzomib and control groups, respectively; 15.3% and 17.7% of patients discontinued treatment owing to adverse events. Patients in the carfilzomib group reported superior health-related quality of life. In patients with relapsed multiple myeloma, the addition of carfilzomib to lenalidomide and dexamethasone resulted in significantly improved progression-free survival at the interim analysis and had a favorable risk-benefit profile. (Funded by Onyx Pharmaceuticals; ClinicalTrials.gov number, NCT01080391.).

  19. ANNUAL REPORT, JULY 1, 1957

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1958-10-31

    The progress and trends of research are presented along with a description of operational, service, end administrative activities. Some scientific and technical details are given on research programs in the physical sciences, life sciences, and engineering, however, more complete technical information is available in quarterly progress reports, BNL technical reports, and scientific and technical periodicals. A bibliography of these publications is appended. (For preceding period see BNL-426.) (D.E.B.)

  20. An Interim Report on NASA's Draft Space Technology Roadmaps

    NASA Technical Reports Server (NTRS)

    2011-01-01

    NASA has developed a set of 14 draft roadmaps to guide the development of space technologies under the leadership of the NASA Office of the Chief Technologist (OCT). Each of these roadmaps focuses on a particular technology area (TA). The roadmaps are intended to foster the development of advanced technologies and concepts that address NASA's needs and contribute to other aerospace and national needs. OCT requested that the National Research Council conduct a study to review the draft roadmaps, gather and assess relevant community input, and make recommendations and suggest priorities to inform NASA's decisions as it finalizes its roadmaps. The statement of task states that "based on the results of the community input and its own deliberations, the steering committee will prepare a brief interim report that addresses high-level issues associated with the roadmaps, such as the advisability of modifying the number or technical focus of the draft NASA roadmaps." This interim report, which does not include formal recommendations, addresses that one element of the study charge. NASA requested this interim report so that it would have the opportunity to make an early start in modifying the draft roadmaps based on feedback from the panels and steering committee. The final report will address all other tasks in the statement of task. In particular, the final report will include a prioritization of technologies, will describe in detail the prioritization process and criteria, and will include specific recommendations on a variety of topics, including many of the topics mentioned in this interim report. In developing both this interim report and the final report to come, the steering committee draws on the work of six study panels organized by technical area, loosely following the organization of the 14 roadmaps, as follows: A Panel 1: Propulsion and Power TA01 Launch Propulsion Systems TA02 In-Space Propulsion Technologies TA03 Space Power and Energy Storage Systems TA13 Ground and Launch Systems Processing B Panel 2: Robotics, Communications, and Navigation TA04 Robotics, TeleRobotics, and Autonomous Systems TA05 Communication and Navigation Systems C Panel 3: Instruments and Computing TA08 Science Instruments, Observatories, and Sensor Systems TA11 Modeling, Simulation, Information Technology, and Data Processing D Panel 4: Human Health and Surface Exploration TA06 Human Health, Life Support, and Habitation Systems TA07 Human Exploration Destination Systems E Panel 5: Materials Panel TA10 Nanotechnology TA12 Materials, Structures, Mechanical Systems, and Manufacturing TA14 Thermal Management Systems F Panel 6: Entry, Descent, and Landing Panel TA09 Entry, Descent, and Landing Systems In addition to drawing on the expertise represented on the steering committee and panels, the committee obtained input from each of 14 public workshops held on each of the 14 roadmaps. At these 1-day workshops, invited speakers, guests, and members of the public engaged in discussions on the different technology areas and their value to NASA. Broad community input was also solicited from a public website, where more than 240 public comments were received on the draft roadmaps in response to application of criteria (such as benefit, risk and reasonableness, and alignment with NASA and national goals) that the steering committee established. This interim report reflects the results of deliberations by the steering committee in light of these public inputs as well as additional inputs from the six panels. The steering committee's final report will be completed early in 2012. That report will prioritize the technologies that span the entire scope of the 14 roadmaps and provide additional guidance on crosscutting themes and other relevant topics.

  1. 20 CFR 411.180 - What is timely progress toward self-supporting employment?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... certificate or vocational or technical training that will enhance your ability to return to work. In addition...-secondary education requirement or vocational or technical training requirement in the applicable progress... this 12-month period; or (iv) You must have been enrolled in a vocational or technical training program...

  2. Status of NASA's Space Launch System

    NASA Technical Reports Server (NTRS)

    Honeycutt, John; Lyles, Garry

    2016-01-01

    NASA's Space Launch System (SLS) continued to make significant progress in 2015 and 2016, completing hardware and testing that brings NASA closer to a new era of deep space exploration. Programmatically, SLS completed Critical Design Review (CDR) in 2015. A team of independent reviewers concluded that the vehicle design is technically and programmatically ready to move to Design Certification Review (DCR) and launch readiness in 2018. Just five years after program start, every major element has amassed development and flight hardware and completed key tests that will lead to an accelerated pace of manufacturing and testing in 2016 and 2017. Key to SLS' rapid progress has been the use of existing technologies adapted to the new launch vehicle. The existing fleet of RS-25 engines is undergoing adaptation tests to prove it can meet SLS requirements and environments with minimal change. The four-segment shuttle-era booster has been modified and updated with a fifth propellant segment, new insulation, and new avionics. The Interim Cryogenic Upper Stage is a modified version of an existing upper stage. The first Block I SLS configuration will launch a minimum of 70 metric tons (t) of payload to low Earth orbit (LEO). The vehicle architecture has a clear evolutionary path to more than 100t and, ultimately, to 130t. Among the program's major 2015-2016 accomplishments were two booster qualification hotfire tests, a series of RS-25 adaptation hotfire tests, manufacturing of most of the major components for both core stage test articles and first flight tank, delivery of the Pegasus core stage barge, and the upper stage simulator. Renovations to the B-2 test stand for stage green run testing was completed at NASA Stennis Space Center. This year will see the completion of welding for all qualification and flight EM-1 core stage components and testing of flight avionics, completion of core stage structural test stands, casting of the EM-1 solid rocket motors, additional testing of RS-25 engines and flight engine controllers This paper will discuss these and other technical and programmatic successes and challenges over the past year and provide a preview of work ahead before the first flight of this new capability.

  3. Status of NASA's Space Launch System

    NASA Technical Reports Server (NTRS)

    Honeycutt, John; Cook, Jerry; Lyles, Garry

    2016-01-01

    NASA's Space Launch System (SLS) continued to make significant progress in 2015, completing hardware and testing that brings NASA closer to a new era of deep space exploration. The most significant program milestone of the year was completion of Critical Design Review (CDR). A team of independent reviewers concluded that the vehicle design is technically and programmatically ready to move to Design Certification Review (DCR) and launch readiness in 2018. Just four years after program start, every major element has amassed development and flight hardware and completed key tests that will set the stage for a growing schedule of manufacturing and testing in 2016. Key to SLS' rapid progress has been the use of existing technologies adapted to the new launch vehicle. The space shuttle-heritage RS-25 engine is undergoing adaptation tests to prove it can meet SLS requirements and environments with minimal change. The four-segment shuttle-era booster has been modified and updated with an additional propellant segment, new insulation, and new avionics. The Interim Cryogenic Upper Stage is a modified version of an existing upper stage. The first Block I SLS configuration will launch a minimum of 70 metric tons of payload to low Earth orbit (LEO). The vehicle architecture has a clear evolutionary path to more than 100 metric tons and, ultimately, to 130 metric tons. Among the program's major accomplishments in 2015 were the first booster qualification hotfire test, a series of seven RS-25 adaptation hotfire tests, manufacturing of most of the major components for both core stage test articles and first flight tank, delivery of the Pegasus core stage barge, and the upper stage simulator. Renovations to the B-2 test stand for stage green run testing was completed at NASA Stennis Space Center. This year will see the second booster qualification motor hotfire, flight and additional development RS-25 engine tests, and completion of core stage test articles and test stands and several flight article sections. This paper will discuss these and other technical and programmatic successes and challenges over the past year and provide a preview of work ahead before the first flight of this new capability.

  4. Status of NASA's Space Launch System

    NASA Technical Reports Server (NTRS)

    Lyles, Garry

    2016-01-01

    NASA's Space Launch System (SLS) continued to make significant progress in 2015, completing hardware and testing that brings NASA closer to a new era of deep space exploration. The most significant program milestone of the year was completion of Critical Design Review (CDR). A team of independent reviewers concluded that the vehicle design is technically and programmatically ready to move to Design Certification Review (DCR) and launch readiness in 2018. Just four years after program start, every major element has amassed development and flight hardware and completed key tests that will set the stage for a growing schedule of manufacturing and testing in 2016. Key to SLS' rapid progress has been the use of existing technologies adapted to the new launch vehicle. The space shuttle-heritage RS-25 engine is undergoing adaptation tests to prove it can meet SLS requirements and environments with minimal change. The four-segment shuttle-era booster has been modified and updated with an additional propellant segment, new insulation, and new avionics. The Interim Cryogenic Upper Stage is a modified version of an existing upper stage. The first Block I SLS configuration will launch a minimum of 70 metric tons (t) of payload to low Earth orbit (LEO). The vehicle architecture has a clear evolutionary path to more than 100t and, ultimately, to 130t. Among the program's major accomplishments in 2015 were the first booster qualification hotfire test, a series of seven RS-25 adaptation hotfire tests, manufacturing of most of the major components for both core stage test articles and first flight tank, delivery of the Pegasus core stage barge, and the upper stage simulator. Renovations to the B-2 test stand for stage green run testing was completed at NASA Stennis Space Center. This year will see the second booster qualification motor hotfire, flight and additional development RS-25 engine tests, and completion of core stage test articles and test stands and several flight article sections. This paper will discuss these and other technical and programmatic successes and challenges over the past year and provide a preview of work ahead before the first flight of this new capability.

  5. Editing Tips for Technical Publications in the Joint Nuclear Weapons Publication System (JNWPS)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    ALLEN, TARA S.

    2002-12-01

    These editing tips contain helpful suggestions to assist writers who are writing, editing, and publishing technical publications in the JNWPS. The suggestions clarify some of the most common writing problems and requirements of two publications used in the JNWPS: ''DOE-DTRA TP 1-1, Joint Nuclear Weapons Publications System Operating Procedures, Specifications, and Standards, and United States Government Printing Office Style Manual''. Topics include requirements for abbreviations, formats for drafts, layouts of illustrations and tables, appropriate wording for interim changes, guidance for creating a list of effective pages, how to insert and delete pages and paragraphs, referencing other technical publications, use ofmore » revision bars, requirements for safety precautions, use of hyphens, and how to place warnings, cautions, and notes. Also included are a writer's checklist, samples of draft title pages, and a section of helpful tips for the writers who use the department's desktop publishing software program, Adobe{reg_sign} FrameMaker{reg_sign}.« less

  6. Cybersecurity vulnerabilities in medical devices: a complex environment and multifaceted problem

    PubMed Central

    Williams, Patricia AH; Woodward, Andrew J

    2015-01-01

    The increased connectivity to existing computer networks has exposed medical devices to cybersecurity vulnerabilities from which they were previously shielded. For the prevention of cybersecurity incidents, it is important to recognize the complexity of the operational environment as well as to catalog the technical vulnerabilities. Cybersecurity protection is not just a technical issue; it is a richer and more intricate problem to solve. A review of the factors that contribute to such a potentially insecure environment, together with the identification of the vulnerabilities, is important for understanding why these vulnerabilities persist and what the solution space should look like. This multifaceted problem must be viewed from a systemic perspective if adequate protection is to be put in place and patient safety concerns addressed. This requires technical controls, governance, resilience measures, consolidated reporting, context expertise, regulation, and standards. It is evident that a coordinated, proactive approach to address this complex challenge is essential. In the interim, patient safety is under threat. PMID:26229513

  7. Cybersecurity vulnerabilities in medical devices: a complex environment and multifaceted problem.

    PubMed

    Williams, Patricia Ah; Woodward, Andrew J

    2015-01-01

    The increased connectivity to existing computer networks has exposed medical devices to cybersecurity vulnerabilities from which they were previously shielded. For the prevention of cybersecurity incidents, it is important to recognize the complexity of the operational environment as well as to catalog the technical vulnerabilities. Cybersecurity protection is not just a technical issue; it is a richer and more intricate problem to solve. A review of the factors that contribute to such a potentially insecure environment, together with the identification of the vulnerabilities, is important for understanding why these vulnerabilities persist and what the solution space should look like. This multifaceted problem must be viewed from a systemic perspective if adequate protection is to be put in place and patient safety concerns addressed. This requires technical controls, governance, resilience measures, consolidated reporting, context expertise, regulation, and standards. It is evident that a coordinated, proactive approach to address this complex challenge is essential. In the interim, patient safety is under threat.

  8. Planning for progress, productivity, and performance.

    PubMed

    Benedict, J M

    1983-10-01

    A project is described for the interim renovation of a labor intensive existing foodservice facility. The renovated area will provide effective food management during the hospital's redevelopment period, including a new foodservice. Objectives of the interim project were to conserve labor while emphasizing control and centralization, provide economic foodservices with improved quality, and incorporate one tray distribution system throughout the hospital complex. Immediate measures were necessary in order to generate funds to proceed. Renovations had to occur without disrupting food-service to patients. The project was planned over a three year period and included an ingredient control area, two patient tray service centres, a renewed production kitchen and test kitchen facility. Each phase has been financed on the understanding that the costs of construction and equipment will be repaid within one fiscal year of operating the renovated facility. Positive results are being achieved, attributable to the support and encouragement received from staff during the change process.

  9. Out Brief for the Structural Reliability Partnership Workshop

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boyce, Brad; Fang, Eliot; Kolski, Alyssa

    The Structural Reliability Partnership Workshop was held in Albuquerque, NM on August 29-30, 2017 and was hosted by Sandia National Laboratories. Attendees were present from academia, industry and several other national laboratories. The workshop kicked off with an introduction to the SRP to familiarize potential members with what the purpose, structure and benefits would be to their organization. Technical overviews were given on several topics by attendees from each sector – national labs, universities and industry – to provide a snapshot of the type of work that is currently being conducted on structural reliability. Attendees were then given the opportunitymore » to suggest and discuss potential Challenge Scenario topics. Three were ultimately decided upon as being the most important: Additive Manufacturing, Hydrogen Pipeline Steels, and Bolted Joined Structures. These were then analyzed using Quad Charts to determine What, How, Who, and Why these areas would be further investigated. Rather than restricting future research to only one area, the option was left open to investigate both the top two, depending on interest and cost associated with hosting such an event. More informal collaboration may be undertaken for the third topic if members have time and interest. Other items discussed pertained to the organization, structure and policies of the Partnership. Topics including Data Management, IP, and mechanisms of partnering/information sharing were touched upon but final decisions were not made. Further action is needed before this can be done. Action items were outlined and assigned, where possible. The next workshop is to be held in early August 2018 in Boulder, CO and is to be hosted by NIST. In the interim, quarterly updates are to take place via WebEx to maintain a line of communication and to ensure progress on both the administrative and technical tasks.« less

  10. Effect of Alcohol on the Spreading Ability of Sodium Hypochlorite Endodontic Irrigant

    DTIC Science & Technology

    1982-09-01

    Research Progress Sodium Hypochlorite Endodontic Irrigant Report (Interim) 6. PERFORMING ORG. REPORT NUMBER 7. AU THOR(s) 8. CONTRACT OR GRANT NUMBER(s...neceewary and Identify by block nam.ber) Alcohol Sodium hypochlorite Endodontics Root canal 20, ABSTRACT (Continue on reveree side If neceeseay and...depressant significantly increased the ability of the sodium hypochlorite endodontic irrigant to penetrate in vitro. A freshly mixed solution containing 30

  11. An Advanced Approach to Simultaneous Monitoring of Multiple Bacteria in Space

    NASA Technical Reports Server (NTRS)

    Eggers, Mitch

    1998-01-01

    This interim report describes progress on the development of spacecraft-compatible methods of nucleic acid preparation and cleanup. Grantee found that performance of a widely-known protocol could be greatly enhanced by the addition of a sizing step to eliminate acids. Testing of alternative adsorptive methods is underway. Grantee also confirmed and extended observation of precipitation of DNA by condensing agents such a spermine at low ionic strength.

  12. Fundamental Understanding of Propellant/Nozzle Interaction for Rocket Nozzle Erosion Minimization Under Very High Pressure Conditions

    DTIC Science & Technology

    2005-08-31

    conditions; with X-ray radiography for erosion rate measurements. A vortex combustor was also designed to simulate propellant product species and to...DATES COVERED Interim Progress Report, August 1, 2004 to July 31, 2005 4. TITLE AND SUBTITLE Fundamental Understanding of Propellant /Nozzle...nozzle erosion by solid- propellant combustion products. Several processes can affect the nozzle erosion rate at high pressure and temperature

  13. BWR Spent Nuclear Fuel Integrity Research and Development Survey for UKABWR Spent Fuel Interim Storage

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bevard, Bruce Balkcom; Mertyurek, Ugur; Belles, Randy

    The objective of this report is to identify issues and support documentation and identify and detail existing research on spent fuel dry storage; provide information to support potential R&D for the UKABWR (United Kingdom Advanced Boiling Water Reactor) Spent Fuel Interim Storage (SFIS) Pre-Construction Safety Report; and support development of answers to questions developed by the regulator. Where there are gaps or insufficient data, Oak Ridge National Laboratory (ORNL) has summarized the research planned to provide the necessary data along with the schedule for the research, if known. Spent nuclear fuel (SNF) from nuclear power plants has historically been storedmore » on site (wet) in spent fuel pools pending ultimate disposition. Nuclear power users (countries, utilities, vendors) are developing a suite of options and set of supporting analyses that will enable future informed choices about how best to manage these materials. As part of that effort, they are beginning to lay the groundwork for implementing longer-term interim storage of the SNF and the Greater Than Class C (CTCC) waste (dry). Deploying dry storage will require a number of technical issues to be addressed. For the past 4-5 years, ORNL has been supporting the U.S. Department of Energy (DOE) in identifying these key technical issues, managing the collection of data to be used in issue resolution, and identifying gaps in the needed data. During this effort, ORNL subject matter experts (SMEs) have become expert in understanding what information is publicly available and what gaps in data remain. To ensure the safety of the spent fuel under normal and frequent conditions of wet and subsequent dry storage, intact fuel must be shown to: 1.Maintain fuel cladding integrity; 2.Maintain its geometry for cooling, shielding, and subcriticality; 3.Maintain retrievability, and damaged fuel with pinhole or hairline cracks must be shown not to degrade further. Where PWR (pressurized water reactor) information is utilized or referenced, justification has been provided as to why the data can be utilized for BWR fuel.« less

  14. Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.

    PubMed

    Aggarwal, Swati P; Zinman, Lorne; Simpson, Elizabeth; McKinley, Jane; Jackson, Katherine E; Pinto, Hanika; Kaufman, Petra; Conwit, Robin A; Schoenfeld, David; Shefner, Jeremy; Cudkowicz, Merit

    2010-05-01

    In a pilot study, lithium treatment slowed progression of amyotrophic lateral sclerosis (ALS). We aimed to confirm or disprove these findings by assessing the safety and efficacy of lithium in combination with riluzole in patients with ALS. We did a double-blind, placebo-controlled trial with a time-to-event design. Between January and June, 2009, patients with ALS who were taking a stable dose of riluzole for at least 30 days were randomly assigned (1:1) by a centralised computer to receive either lithium or placebo. Patients, caregivers, investigators, and all site study staff with the exception of site pharmacists were masked to treatment assignment. The primary endpoint was the time to an event, defined as a decrease of at least six points on the revised ALS functional rating scale score or death. Interim analyses were planned for when 84 patients had been allocated treatment, 6 months later or after 55 events, and after 100 events. Analysis was by intention to treat. The stopping boundary for futility at the first interim analysis was a p value of at least 0.68. We used a log-rank test to compare the distributions of the time to an event between the lithium and placebo groups. This trial is registered with ClinicalTrials.gov, NCT00818389. At the first interim analysis, 22 of 40 patients in the lithium group had an event compared with 20 of 44 patients in the placebo group (log rank p=0.51). The hazard ratio of reaching the primary endpoint was 1.13 (95% CI 0.61-2.07). The study was stopped at the first interim analysis because criterion for futility was met (p=0.78). The difference in mean decline in the ALS functional rating scale score between the lithium group and the placebo group was 0.15 (95% CI -0.43 to 0.73, p=0.61). There were no major safety concerns. Falls (p=0.04) and back pain (p=0.05) were more common in the lithium group than in the placebo group. We found no evidence that lithium in combination with riluzole slows progression of ALS more than riluzole alone. The time-to-event endpoint and use of prespecified interim analyses enabled a clear result to be obtained rapidly. This design should be considered for future trials testing the therapeutic efficacy of drugs that are easily accessible to people with ALS. National Institute of Neurological Disorders and Stroke, ALS Association, and ALS Society of Canada. Copyright 2010 Elsevier Ltd. All rights reserved.

  15. R&D on Composition and Processing of Titanium Aluminide Alloys for Turbine Engines

    DTIC Science & Technology

    1982-07-01

    45433. AUTHORITY AFWAL ltr, 6 Feb 1987 THIS PAGE IS UNCLASSIFIED AFWAL-TR-82-4086 R&D ON COMPOSITION AND PROCESSING4 OF TITANIUM ALUMINIDE ALLOYS FOR...TR-82-4086- 4. TITLE (and Subitfle) S TYPE OF REPORT I PERIOO COVEREO R&D ON COMPOSITION AND PROCESSING OF Interim Technical Report TITANIUM ALUMINIDE ...ILLUSTRATIONS FICURE PACE 1 As-received titanium aluminide ingots supplied 9 by RMI. (a) S/N 20007; (b) left to right, S/N 20008, S/N 20009, S/N 20010

  16. Analysis of Multiple-Impact Ballistic Performance of a Tempered Glass Laminate with a Strike Face Film

    DTIC Science & Technology

    2014-02-01

    a 0.18 in thick polymer interlayer between two layers of 0.5 in tempered silica based “ soda lime ” glass . A 0.08 in shatter resistant film was...AFCEC-CX-TY-TR-2014-0005 ANALYSIS OF MULTIPLE-IMPACT BALLISTIC PERFORMANCE OF A TEMPERED GLASS LAMINATE WITH A STRIKE FACE FILM Michael A. Magrini...Interim Technical Report 3 JAN 2012 to 2 JAN 2013 Analysis of Multiple-Impact Ballistic Performance of A Tempered Glass Laminate with a Strike Face Film

  17. Role Perceptions of Hispanic and Mainstream Navy Recruits.

    DTIC Science & Technology

    1982-12-01

    ACCESSION NO- 3. R9C’PI’NT’S CATALOG NUMBER 4. TITLE (and Subttl.e) S . TYPE of REPORT & PERIOO COVERED Role Perceptions of Hispanic and M4ainstream Interim...Technical Report Navy Recruits *. PERFORMING ORG. REPORT NUMBER 7. AUTHOR( s ) 6. CONTRACT OR GRANT NUMUER(a) Harry C. Triandis Judith Li3ansky Gerardo...T NU M E R S A Department of Psycholog~y University of Illinois NR 170-906 603 E. Daniel, Chamva.;vn, IL 6182__ II. CONTROLLING OFFICE NAME AND

  18. Evaporation by mechanical vapor recompression. Technical progress report, September 1-December 31, 1979

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Iverson, C.H.; Coury, G.E.

    1979-01-01

    Progress to date in the development of a study of the application of the technologies of mechanical vapor recompression and falling film evaporators as applied to the beet sugar industry is reported. Progress is reported in the following areas: technical literature search and plant visitations of existing applications of VR/FFE.

  19. MODTRAN: a moderate resolution model for LOWTRAN. Technical report, 12 May 1986-11 May 1987

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Berk, A.; Bernstein, L.S.; Robertson, D.C.

    1987-07-08

    This interim technical report describes a new band-model formulation for the LOWTRAN 6 atmospheric transmittance/radiation computer code. Band-model parameters for H/sub 2/O, CO/sub 2/, O/sub 3/, CO, CH/sub 4/, O/sub 2/, and N/sub 2/ were calculated using the 1986 HITRAN line atlas. They were calculated for 1 /cm bins from 0 - 17,900/cm and at five temperatures from 200 to 300K. This transmittance model and associated subroutines were integrated into LOWTRAN 6. The spectral resolution of this new option is better than 5/cm (FWHM). A preliminary version of the code was delivered to AFGL for testing. Validation against FASCOD2 calculationsmore » will be the emphasis for the remainder of this effort.« less

  20. Nondestructive Assay Data Integration with the SKB-50 Assemblies - FY16 Update

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tobin, Stephen Joseph; Fugate, Michael Lynn; Trellue, Holly Renee

    2016-10-28

    A project to research the application of non-destructive assay (NDA) techniques for spent fuel assemblies is underway at the Central Interim Storage Facility for Spent Nuclear Fuel (for which the Swedish acronym is Clab) in Oskarshamn, Sweden. The research goals of this project contain both safeguards and non-safeguards interests. These nondestructive assay (NDA) technologies are designed to strengthen the technical toolkit of safeguard inspectors and others to determine the following technical goals more accurately; Verify initial enrichment, burnup, and cooling time of facility declaration for spent fuel assemblies; Detect replaced or missing pins from a given spent fuel assembly tomore » confirm its integrity; and Estimate plutonium mass and related plutonium and uranium fissile mass parameters in spent fuel assemblies. Estimate heat content, and measure reactivity (multiplication).« less

  1. 25 CFR 30.109 - Will the Secretary provide assistance in developing an alternative AYP definition?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Technical Assistance § 30.109 Will the... Bureau, shall provide technical assistance either directly or through contract to the tribal governing...

  2. 25 CFR 30.109 - Will the Secretary provide assistance in developing an alternative AYP definition?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Technical Assistance § 30.109 Will the... Bureau, shall provide technical assistance either directly or through contract to the tribal governing...

  3. Medicare Program; Cancellation of Advancing Care Coordination Through Episode Payment and Cardiac Rehabilitation Incentive Payment Models; Changes to Comprehensive Care for Joint Replacement Payment Model: Extreme and Uncontrollable Circumstances Policy for the Comprehensive Care for Joint Replacement Payment Model. Final rule; interim final rule with comment period.

    PubMed

    2017-12-01

    This final rule cancels the Episode Payment Models (EPMs) and Cardiac Rehabilitation (CR) Incentive Payment Model and rescinds the regulations governing these models. It also implements certain revisions to the Comprehensive Care for Joint Replacement (CJR) model, including: Giving certain hospitals selected for participation in the CJR model a one-time option to choose whether to continue their participation in the model; technical refinements and clarifications for certain payment, reconciliation and quality provisions; and a change to increase the pool of eligible clinicians that qualify as affiliated practitioners under the Advanced Alternative Payment Model (Advanced APM) track. An interim final rule with comment period is being issued in conjunction with this final rule in order to address the need for a policy to provide some flexibility in the determination of episode costs for providers located in areas impacted by extreme and uncontrollable circumstances.

  4. Monitoring the Durability Performance of Concrete in Nuclear Waste Containment. Technical Progress Report No. 3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ulm, Franz-Josef

    2000-03-31

    OAK-B135 Monitoring the Durability Performance of Concrete in Nuclear Waste Containment. Technical Progress Report No. 3(NOTE: Part II A item 1 indicates ''PAPER'', but a report is attached electronically)

  5. Our Lady of Hungary Catholic School, Indiana. School Achieves Double-Digit Growth with the Help of Interim and Classroom Formative Assessment Data. Case Study: Measures of Academic Progress & Professional Development.

    ERIC Educational Resources Information Center

    Northwest Evaluation Association, 2015

    2015-01-01

    In 2014, South Bend's Our Lady of Hungary Catholic School welcomed its third principal in four years: Kevin Goralczyk, an Indiana native and seasoned educator. Together with the parish's pastor, Reverend Kevin Bauman, Principal Goralczyk began exploring how OLH could raise its pre-K-8 student achievement and better support teachers and staff…

  6. Draft report: Results of stainless steel canister corrosion studies and environmental sample investigations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bryan, Charles R.; Enos, David

    2014-09-01

    This progress report describes work being done at Sandia National Laboratories (SNL) to assess the localized corrosion performance of container/cask materials used in the interim storage of used nuclear fuel. The work involves both characterization of the potential physical and chemical environment on the surface of the storage canisters and how it might evolve through time, and testing to evaluate performance of the canister materials under anticipated storage conditions.

  7. Crosscutting Technology Development at the Center for Advanced Separation Technologies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Christopher E. Hull

    2006-09-30

    This Technical Progress Report describes progress made on the twenty nine subprojects awarded in the second year of Cooperative Agreement DE-FC26-02NT41607: Crosscutting Technology Development at the Center for Advanced Separation Technologies. This work is summarized in the body of the main report: the individual sub-project Technical Progress Reports are attached as Appendices.

  8. CROSSCUTTING TECHNOLOGY DEVELOPMENT AT THE CENTER FOR ADVANCED SEPARATION TECHNOLOGIES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Christopher E. Hull

    2006-05-15

    This Technical Progress Report describes progress made on the twenty nine subprojects awarded in the second year of Cooperative Agreement DE-FC26-02NT41607: Crosscutting Technology Development at the Center for Advanced Separation Technologies. This work is summarized in the body of the main report: the individual sub-project Technical Progress Reports are attached as Appendices.

  9. The Development and Technical Adequacy of Seventh-Grade Reading Comprehension Measures in a Progress Monitoring Assessment System. Technical Report #1102

    ERIC Educational Resources Information Center

    Park, Bitnara Jasmine; Alonzo, Julie; Tindal, Gerald

    2011-01-01

    This technical report describes the process of development and piloting of reading comprehension measures that are appropriate for seventh-grade students as part of an online progress screening and monitoring assessment system, http://easycbm.com. Each measure consists of an original fictional story of approximately 1,600 to 1,900 words with 20…

  10. Generation and focusing of pulsed intense ion beams. Technical progress report, 1 October 1982 - 30 September, 1983

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hammer, D.A.; Kusse, B.R.; Sudan, R.N.

    1983-07-01

    The progress on this contract is described in three parts. The first deals with the technical operation of the LION accelerator. The second and third parts are concerned with the experimental results.

  11. Analysis of Transportation Options for Commercial Spent Fuel in the U.S.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kalinina, Elena; Busch, Ingrid Karin

    The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S.more » Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage The U.S. Department of Energy (DOE) is laying the groundwork for implementing interim storage and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF) and high and associated transportation of spent nuclear fuel (SNF) high and associated transportation of spent nuclear fuel (SNF) highand associated transportation of spent nuclear fuel (SNF)...« less

  12. The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Kindergarten. Technical Report # 0921

    ERIC Educational Resources Information Center

    Alonzo, Julie; Tindal, Gerald

    2009-01-01

    In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in kindergarten. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2008 and administered to approximately 2800 students from…

  13. Modified Interim Mandibular Advancement (MIMA) Appliance for Symptomatic Correction of Obstructive Sleep Apnea

    PubMed Central

    Singh, Harpreet; Mishra, Harsh Ashok; Gupta, Ankur

    2016-01-01

    Obstructive Sleep Apnea (OSA) is a chronic, progressive, multifactorial, life-threatening disorder that causes significant impact on patient’s life. Patients with OSA [Apnea/Hypopnea Index (AHI)>30] who cannot tolerate Continuous Positive Airway Pressure (CPAP) therapy or are not surgical candidates may benefit from oral appliances. This paper describes interim appliance devised from existing Hawley’s retainer in patients with OSA. A 38-year-old man of athletic built with history of orthodontic treatment six months back due to esthetic concerns and wearing upper Hawley’s retainer, reported with chief complaint of frequent nocturnal awakening along with excessive daytime somnolence. Based on diagnostic aids, he was diagnosed with Class II Division 1 malocclusion with severe mandibular retrusion. Sleep test revealed AHI score of 34, suggestive of severe OSA. With ENT and Oral surgeon concurrence, mandibular advancement of 7mm with Bilateral Sagital Split Osteotomy (BSSO) with distraction was contemplated as a viable functional and curative stable treatment plan. Because of non-adherence and non-compliance with CPAP therapy and on request of patient, an interim anterior positioning appliance was devised to facilitate comfortable sound sleep till the time surgery is impending. After three months of wearing this customized appliance, improved quality of sleep was discernible; both subjectively as reported by patient and objectively using sleep test (AHI=9.8). PMID:27656589

  14. Assessment Program Technical Progress Report, 1996-1997.

    ERIC Educational Resources Information Center

    McCown, Laurie; Fanning, Erin; Eickmeyer, Barbara

    Coconino Community College (CCC) annually assesses its institutional effectiveness to demonstrate its commitment to improving programs and services to students. The 1996-97 Assessment Program Technical Progress Report records the assessment and institutional activities enacted during the academic year, detailing the assessment model, timelines,…

  15. Usefulness of Interim FDG-PET After Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Sequential Induction Chemotherapy Followed by Concurrent Chemoradiotherapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yoon, Dok Hyun; Cho, Yoojin; Kim, Sang Yoon

    2011-09-01

    Purpose: Induction chemotherapy (ICT) has been used to select patients for organ preservation and determine subsequent treatments in patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN). Still, the clinical outcomes of LASCCHN patients who showed response to ICT are heterogeneous. We evaluated the efficacy of interim 18-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) after ICT in this specific subgroup of LASCCHN patients who achieved partial response (PR) after ICT to predict clinical outcomes after concurrent chemoradiotherapy (CCRT). Methods and Materials: Twenty-one patients with LASCCHN who showed PR to ICT by Response Evaluation Criteria In Solid Tumors beforemore » definitive CCRT were chosen in this retrospective analysis. FDG-PET was performed before and 2-4 weeks after ICT to assess the extent of disease at baseline and the metabolic response to ICT, respectively. We examined the correlation of the metabolic response by the percentage decrease of maximum standardized uptake value (SUVmax) on the primary tumor or lymph node after ICT or a specific threshold of SUVmax on interim FDG-PET with clinical outcomes including complete response (CR) rate to CCRT, progression-free survival (PFS), and overall survival (OS). Results: A SUVmax of 4.8 on interim FDG-PET could predict clinical CR after CCRT (100% vs. 20%, p = 0.001), PFS (median, not reached vs. 8.5 mo, p < 0.001), and OS (median, not reached vs. 12.0 months, p = 0.001) with a median follow-up of 20.3 months in surviving patients. A 65% decrease in SUVmax after ICT from baseline also could predict clinical CR after CCRT (100% vs. 33.3%, p = 0.003), PFS (median, not reached vs. 8.9 months, p < 0.001) and OS (median, not reached vs. 24.4 months, p = 0.001) of the patients. Conclusion: These data suggest that interim FDG-PET after ICT might be a useful determinant to predict clinical outcomes in patients with LASCCHN receiving sequential ICT followed by CCRT.« less

  16. Progress on plutonium stabilization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hurt, D.

    1996-05-01

    The Defense Nuclear Facilities Safety Board has safety oversight responsibility for most of the facilities where unstable forms of plutonium are being processed and packaged for interim storage. The Board has issued recommendations on plutonium stabilization and has has a considerable influence on DOE`s stabilization schedules and priorities. The Board has not made any recommendations on long-term plutonium disposition, although it may get more involved in the future if DOE develops plans to use defense nuclear facilities for disposition activities.

  17. CIM's bridge from CADD to CAM: Data management requirements for manufacturing engineering

    NASA Technical Reports Server (NTRS)

    Ford, S. J.

    1984-01-01

    Manufacturing engineering represents the crossroads of technical data management in a Computer Integrated Manufacturing (CIM) environment. Process planning, numerical control programming and tool design are the key functions which translate information from as engineered to as assembled. In order to transition data from engineering to manufacturing, it is necessary to introduce a series of product interpretations which contain an interim introduction of technical parameters. The current automation of the product definition and the production process places manufacturing engineering in the center of CAD/CAM with the responsibility of communicating design data to the factory floor via a manufacturing model of the data. A close look at data management requirements for manufacturing engineering is necessary in order to establish the overall specifications for CADD output, CAM input, and CIM integration. The functions and issues associated with the orderly evolution of computer aided engineering and manufacturing are examined.

  18. The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 1. Technical Report # 0919

    ERIC Educational Resources Information Center

    Alonzo, Julie; Tindal, Gerald

    2009-01-01

    In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grade 1. These measures, available as part of easyCBM [TM], an online progress monitoring assessment system, were developed in 2008 and administered to approximately 2800 students from schools…

  19. The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 3. Technical Report # 09-02

    ERIC Educational Resources Information Center

    Alonzo, Julie; Lai, Cheng Fei; Tindal, Gerald

    2009-01-01

    In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

  20. The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 2. Technical Report # 0920

    ERIC Educational Resources Information Center

    Alonzo, Julie; Lai, Cheng Fei; Tindal, Gerald

    2009-01-01

    In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

  1. The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 5. Technical Report # 09-01

    ERIC Educational Resources Information Center

    Lai, Cheng Fei; Alonzo, Julie; Tindal, Gerald

    2009-01-01

    In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

  2. The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 4. Technical Report # 09-03

    ERIC Educational Resources Information Center

    Alonzo, Julie; Lai, Cheng Fei; Tindal, Gerald

    2009-01-01

    In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

  3. The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 7. Technical Report 0908

    ERIC Educational Resources Information Center

    Lai, Cheng Fei; Alonzo, Julie; Tindal, Gerald

    2009-01-01

    In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

  4. The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 8. Technical Report # 09-04

    ERIC Educational Resources Information Center

    Lai, Cheng Fei; Alonzo, Julie; Tindal, Gerald

    2009-01-01

    In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

  5. Northeast Artificial Intelligence Consortium Annual Report 1986. Volume 4. Part A. Hierarchical Region-Based Approach to Automatic Photointerpretation. Part B. Application of AI Techniques to Image Segmentation and Region Identification

    DTIC Science & Technology

    1988-01-01

    MONITORING ORGANIZATION Northeast Artificial (If applicaole)nelincCostum(AcRome Air Development Center (COCU) Inteligence Consortium (NAIC)I 6c. ADDRESS...f, Offell RADC-TR-88-1 1, Vol IV (of eight) Interim Technical ReportS June 1988 NORTHEAST ARTIFICIAL INTELLIGENCE CONSORTIUM ANNUAL REPORT 1986...13441-5700 EMENT NO NO NO ACCESSION NO62702F 5 8 71 " " over) I 58 27 13 " ൓ TITLE (Include Security Classification) NORTHEAST ARTIFICIAL INTELLIGENCE

  6. FY17 Status Report: Research on Stress Corrosion Cracking of SNF Interim Storage Canisters.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schindelholz, Eric John; Bryan, Charles R.; Alexander, Christopher L.

    This progress report describes work done in FY17 at Sandia National Laboratories (SNL) to assess the localized corrosion performance of container/cask materials used in the interim storage of spent nuclear fuel (SNF). Of particular concern is stress corrosion cracking (SCC), by which a through-wall crack could potentially form in a canister outer wall over time intervals that are shorter than possible dry storage times. Work in FY17 refined our understanding of the chemical and physical environment on canister surfaces, and evaluated the relationship between chemical and physical environment and the form and extent of corrosion that occurs. The SNL corrosionmore » work focused predominantly on pitting corrosion, a necessary precursor for SCC, and process of pit-to-crack transition; it has been carried out in collaboration with university partners. SNL is collaborating with several university partners to investigate SCC crack growth experimentally, providing guidance for design and interpretation of experiments.« less

  7. Storage for greater-than-Class C low-level radioactive waste

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Beitel, G.A.

    1991-12-31

    EG and G Idaho, Inc., at the Idaho National Engineering Laboratory (INEL) is actively pursuing technical storage alternatives for greater-than-Class C low-level radioactive waste (GTCC LLW) until a suitable licensed disposal facility is operating. A recently completed study projects that between 2200 and 6000 m{sup 3} of GTCC LLW will be generated by the year 2035; the base case estimate is 3250 m{sup 3}. The current plan envisions a disposal facility available as early as the year 2010. A long-term dedicated storage facility could be available in 1997. In the meantime, it is anticipated that a limited number of sealedmore » sources that are no longer useful and have GTCC concentrations of radionuclides will require storage. Arrangements are being made to provide this interim storage at an existing DOE waste management facility. All interim stored waste will subsequently be moved to the dedicated storage facility once it is operating. Negotiations are under way to establish a host site for interim storage, which may be operational, at the earliest, by the second quarter of 1993. Two major activities toward developing a long-term dedicated storage facility are ongoing. (a) An engineering study, which explores costs for alternatives to provide environmentally safe storage and satisfy all regulations, is being prepared. Details of some of the findings of that study will be presented. (b) There is also an effort under way to seek the assistance of one or more private companies in providing dedicated storage. Alternatives and options will be discussed.« less

  8. Development and Validation of a Novel Scoring System for Predicting Technical Success of Chronic Total Occlusion Percutaneous Coronary Interventions: The PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) Score.

    PubMed

    Christopoulos, Georgios; Kandzari, David E; Yeh, Robert W; Jaffer, Farouc A; Karmpaliotis, Dimitri; Wyman, Michael R; Alaswad, Khaldoon; Lombardi, William; Grantham, J Aaron; Moses, Jeffrey; Christakopoulos, Georgios; Tarar, Muhammad Nauman J; Rangan, Bavana V; Lembo, Nicholas; Garcia, Santiago; Cipher, Daisha; Thompson, Craig A; Banerjee, Subhash; Brilakis, Emmanouil S

    2016-01-11

    This study sought to develop a novel parsimonious score for predicting technical success of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) performed using the hybrid approach. Predicting technical success of CTO PCI can facilitate clinical decision making and procedural planning. We analyzed clinical and angiographic parameters from 781 CTO PCIs included in PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) using a derivation and validation cohort (2:1 sampling ratio). Variables with strong association with technical success in multivariable analysis were assigned 1 point, and a 4-point score was developed from summing all points. The PROGRESS CTO score was subsequently compared with the J-CTO (Multicenter Chronic Total Occlusion Registry in Japan) score in the validation cohort. Technical success was 92.9%. On multivariable analysis, factors associated with technical success included proximal cap ambiguity (beta coefficient [b] = 0.88), moderate/severe tortuosity (b = 1.18), circumflex artery CTO (b = 0.99), and absence of "interventional" collaterals (b = 0.88). The resulting score demonstrated good calibration and discriminatory capacity in the derivation (Hosmer-Lemeshow chi-square = 2.633; p = 0.268, and receiver-operator characteristic [ROC] area = 0.778) and validation (Hosmer-Lemeshow chi-square = 5.333; p = 0.070, and ROC area = 0.720) subset. In the validation cohort, the PROGRESS CTO and J-CTO scores performed similarly in predicting technical success (ROC area 0.720 vs. 0.746, area under the curve difference = 0.026, 95% confidence interval = -0.093 to 0.144). The PROGRESS CTO score is a novel useful tool for estimating technical success in CTO PCI performed using the hybrid approach. Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  9. The Time Needed to Implement the Blue Ribbon Commission Recommendation on Interim Storage - 13124

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Voegele, Michael D.; Vieth, Donald

    2013-07-01

    The report of the Blue Ribbon Commission on America's Nuclear Future [1] makes a number of important recommendations to be considered if Congress elects to redirect U.S. high-level radioactive waste disposal policy. Setting aside for the purposes of this discussion any issues related to political forces leading to stopping progress on the Yucca Mountain project and driving the creation of the Commission, an important recommendation of the Commission was to institute prompt efforts to develop one or more consolidated storage facilities. The Blue Ribbon Commission noted that this recommended strategy for future storage and disposal facilities and operations should bemore » implemented regardless of what happens with Yucca Mountain. It is too easy, however, to focus on interim storage as an alternative to geologic disposal. The Blue Ribbon Commission report does not go far enough in addressing the magnitude of the contentious problems associated with reopening the issues of relative authorities of the states and federal government with which Congress wrestled in crafting the Nuclear Waste Policy Act [2]. The Blue Ribbon Commission recommendation for prompt adoption of an interim storage program does not appear to be fully informed about the actions that must be taken, the relative cost of the effort, or the realistic time line that would be involved. In essence, the recommendation leaves to others the details of the systems engineering analyses needed to understand the nature and details of all the operations required to reach an operational interim storage facility without derailing forever the true end goal of geologic disposal. The material presented identifies a number of impediments that must be overcome before the country could develop a centralized federal interim storage facility. In summary, and in the order presented, they are: 1. Change the law, HJR 87, PL 107-200, designating Yucca Mountain for the development of a repository. 2. Bring new nuclear waste legislation to the floor of the Senate, overcoming existing House support for Yucca Mountain; 3. Change the longstanding focus of Congress from disposal to storage; 4. Change the funding concepts embodied in the Nuclear Waste Policy Act to allow the Nuclear Waste fund to be used to pay for interim storage; 5. Reverse the Congressional policy not to give states or tribes veto or consent authority, and to reserve to Congress the authority to override a state or tribal disapproval; 6. Promulgate interim storage facility siting regulations to reflect the new policies after such changes to policy and law; 7. Complete already underway changes to storage and transportation regulations, possibly incorporating changes to reflect changes to waste disposal law; 8. Promulgate new repository siting regulations if the interim storage facility is to support repository development; 9. Identify volunteer sites, negotiate agreements, and get Congressional approval for negotiated benefits packages; 10. Design, License and develop the interim storage facility. The time required to accomplish these ten items depends on many factors. The estimate developed assumes that certain of the items must be completed before other items are started; given past criticisms of the current program, such an assumption appears appropriate. Estimated times for completion of individual items are based on historical precedent. (authors)« less

  10. Performance and technical feasibility comparison of reusable launch systems: A synthesis of the ESA winged launcher studies

    NASA Astrophysics Data System (ADS)

    Berry, W.; Grallert, H.

    1996-02-01

    The paper presents a synthesis of the performance and technical feasibility assessment of 7 reusable launcher types, comprising 13 different vehicles, studied by European Industry for ESA in the ESA Winged Launcher Study in the period January 1988 to May 1994. The vehicles comprised single-stage-to-orbit (SSTO) and two-stage-to-orbit (TSTO) vehicles, propelled by either air-breathing/rocket propulsion or entirely by rocket propulsion. The results showed that an SSTO vehicle of the HOTOL-type, propelled by subsonic combustion air-breathing/rocket engines could barely deliver the specified payload mass and was aerodynamically unstable; that a TSTO vehicle of the Saenger type, employing subsonic combustion airbreathing propulsion in its first stage and rocket propulsion in its second stage, could readily deliver the specified payload mass and was found to be technically feasible and versatile; that an SSTO vehicle of the NASP type, propelled by supersonic combustion airbreathing/rocket propulsion was able to deliver a reduced payload mass, was very complex and required very advanced technologies; that an air-launched rocket propelled vehicle of the Interim HOTOL type, although technically feasible, could deliver only a reduced payload mass, being constrained by the lifting capability of the carrier airplane; that three different, entirely rocket-propelled vehicles could deliver the specified payload mass, were technically feasible but required relatively advanced technologies.

  11. Randomized, placebo-controlled, phase III trial of sunitinib plus prednisone versus prednisone alone in progressive, metastatic, castration-resistant prostate cancer.

    PubMed

    Michaelson, M Dror; Oudard, Stephane; Ou, Yen-Chuan; Sengeløv, Lisa; Saad, Fred; Houede, Nadine; Ostler, Peter; Stenzl, Arnulf; Daugaard, Gedske; Jones, Robert; Laestadius, Fredrik; Ullèn, Anders; Bahl, Amit; Castellano, Daniel; Gschwend, Juergen; Maurina, Tristan; Chow Maneval, Edna; Wang, Shaw-Ling; Lechuga, Maria Jose; Paolini, Jolanda; Chen, Isan

    2014-01-10

    We evaluated angiogenesis-targeted sunitinib therapy in a randomized, double-blind trial of metastatic castration-resistant prostate cancer (mCRPC). Men with progressive mCRPC after docetaxel-based chemotherapy were randomly assigned 2:1 to receive sunitinib 37.5 mg/d continuously or placebo. Patients also received oral prednisone 5 mg twice daily. The primary end point was overall survival (OS); secondary end points included progression-free survival (PFS). Two interim analyses were planned. Overall, 873 patients were randomly assigned to receive sunitinib (n = 584) or placebo (n = 289). The independent data monitoring committee stopped the study for futility after the second interim analysis. After a median overall follow-up of 8.7 months, median OS was 13.1 months and 11.8 months for sunitinib and placebo, respectively (hazard ratio [HR], 0.914; 95% CI, 0.762 to 1.097; stratified log-rank test, P = .168). PFS was significantly improved in the sunitinib arm (median 5.6 v 4.1 months; HR, 0.725; 95% CI, 0.591 to 0.890; stratified log-rank test, P < .001). Toxicity and rates of discontinuations because of adverse events (AEs; 27% v 7%) were greater with sunitinib than placebo. The most common treatment-related grade 3/4 AEs were fatigue (9% v 1%), asthenia (8% v 2%), and hand-foot syndrome (7% v 0%). Frequent treatment-emergent grade 3/4 hematologic abnormalities were lymphopenia (20% v 11%), anemia (9% v 8%), and neutropenia (6% v < 1%). The addition of sunitinib to prednisone did not improve OS compared with placebo in docetaxel-refractory mCRPC. The role of antiangiogenic therapy in mCRPC remains investigational.

  12. Venetoclax for chronic lymphocytic leukaemia progressing after ibrutinib: an interim analysis of a multicentre, open-label, phase 2 trial.

    PubMed

    Jones, Jeffrey A; Mato, Anthony R; Wierda, William G; Davids, Matthew S; Choi, Michael; Cheson, Bruce D; Furman, Richard R; Lamanna, Nicole; Barr, Paul M; Zhou, Lang; Chyla, Brenda; Salem, Ahmed Hamed; Verdugo, Maria; Humerickhouse, Rod A; Potluri, Jalaja; Coutre, Steven; Woyach, Jennifer; Byrd, John C

    2018-01-01

    Therapy targeting Bruton's tyrosine kinase (BTK) with ibrutinib has transformed the treatment of chronic lymphocytic leukaemia. However, patients who are refractory to or relapse after ibrutinib therapy have poor outcomes. Venetoclax is a selective, orally bioavailable inhibitor of BCL-2 active in previously treated patients with relapsed or refractory chronic lymphocytic leukaemia. In this study, we assessed the activity and safety of venetoclax in patients with chronic lymphocytic leukaemia who are refractory to or relapse during or after ibrutinib therapy. In this interim analysis of a multicentre, open-label, non-randomised, phase 2 trial, we enrolled patients aged 18 years or older with a documented diagnosis of chronic lymphocytic leukaemia according to the 2008 International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria and an Eastern Cooperative Oncology Group performance score of 2 or lower. All patients had relapsed or refractory disease after previous treatment with a BCR signalling pathway inhibitor. All patients were screened for Richter's transformation and cases confirmed by biopsy were excluded. Eligible patients received oral venetoclax, starting at 20 mg per day with stepwise dose ramp-up over 5 weeks to 400 mg per day. Patients with rapidly progressing disease received an accelerated dosing schedule (to 400 mg per day by week 3). The primary endpoint was overall response, defined as the proportion of patients with an overall response per investigator's assessment according to IWCLL criteria. All patients who received at least one dose of venetoclax were included in the activity and safety analyses. This study is ongoing; data for this interim analysis were collected per regulatory agencies' request as of June 30, 2017. This trial is registered with ClinicalTrials.gov, number NCT02141282. Between September, 2014, and November, 2016, 127 previously treated patients with relapsed or refractory chronic lymphocytic leukaemia were enrolled from 15 sites across the USA. 91 patients had received ibrutinib as the last BCR inhibitor therapy before enrolment, 43 of whom were enrolled in the main cohort and 48 in the expansion cohort recruited later after a protocol amendment. At the time of analysis, the median follow-up was 14 months (IQR 8-18) for all 91 patients, 19 months (9-27) for the main cohort, and 12 months (8-15) for the expansion cohort. 59 (65%, 95% CI 53-74) of 91 patients had an overall response, including 30 (70%, 54-83) of 43 patients in the main cohort and 29 (60%, 43-72) of 48 patients in the expansion cohort. The most common treatment-emergent grade 3 or 4 adverse events were neutropenia (46 [51%] of 91 patients), thrombocytopenia (26 [29%]), anaemia (26 [29%]), decreased white blood cell count (17 [19%]), and decreased lymphocyte count (14 [15%]). 17 (19%) of 91 patients died, including seven because of disease progression. No treatment-related deaths occurred. The results of this interim analysis show that venetoclax has durable clinical activity and favourable tolerability in patients with relapsed or refractory chronic lymphocytic leukaemia whose disease progressed during or after discontinutation of ibrutinib therapy. The durability of response to venetoclax will be assessed in the final analysis in 2019. AbbVie, Genentech. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. Final report : for the period of December 1999 through November 30, 2000 : Florida Transit Training Program (1999/2000) : Florida Technical Assistance Program (1999/2000)

    DOT National Transportation Integrated Search

    2000-01-01

    The following progress report is intended to highlight the significant activities of the Florida Transit Training Program and Florida Technical Assistant Program. The following progress report is intended to highlight the significant activities of th...

  14. Annual progress report : for the period of January 2001 through December 2001 : Florida Transit Training Program (2001) : Florida Technical Assistance Program (2001)

    DOT National Transportation Integrated Search

    2001-01-01

    The following progress report is intended to highlight the significant activities of the Florida Transit Training Program and Florida Technical Assistant Program for the 2001 year. Activities of the Florida Statewide Transit Training Program are pres...

  15. 76 FR 4369 - Interim Deputation Agreements; Interim BIA Adult Detention Facility Guidelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Adult Detention Facility Guidelines AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice. SUMMARY: This notice announces the online publication of the Interim BIA Adult Detention Facility Guidelines and... Indian Affairs Web site. DATES: These Interim BIA Adult Detention Facility Guidelines and Interim Model...

  16. 24 CFR 35.820 - Interim controls.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Interim controls. 35.820 Section 35...-Possession Multifamily Property § 35.820 Interim controls. HUD shall conduct interim controls in accordance... accordance with § 35.815. Interim controls are considered completed when clearance is achieved in accordance...

  17. 24 CFR 35.820 - Interim controls.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Interim controls. 35.820 Section 35...-Possession Multifamily Property § 35.820 Interim controls. HUD shall conduct interim controls in accordance... accordance with § 35.815. Interim controls are considered completed when clearance is achieved in accordance...

  18. 76 FR 64083 - Reliability Technical Conference; Notice of Technical Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, November 29, 2011, from 1 p.m. to 5 p.m. and... System. The conference will explore the progress made on the priorities for addressing risks to...

  19. 48 CFR 2052.211-70 - Preparation of technical reports.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ....211-70 Preparation of technical reports. As prescribed at 2011.104-70(a), the contracting officer... Reports (JAN 1993) All technical reports required by Section C and all Technical Progress Reports required... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Preparation of technical...

  20. 48 CFR 2052.211-70 - Preparation of technical reports.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....211-70 Preparation of technical reports. As prescribed at 2011.104-70(a), the contracting officer... Reports (JAN 1993) All technical reports required by Section C and all Technical Progress Reports required... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Preparation of technical...

  1. 48 CFR 2052.211-70 - Preparation of technical reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....211-70 Preparation of technical reports. As prescribed at 2011.104-70(a), the contracting officer... Reports (JAN 1993) All technical reports required by Section C and all Technical Progress Reports required... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Preparation of technical...

  2. 48 CFR 2052.211-70 - Preparation of technical reports.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ....211-70 Preparation of technical reports. As prescribed at 2011.104-70(a), the contracting officer... Reports (JAN 1993) All technical reports required by Section C and all Technical Progress Reports required... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Preparation of technical...

  3. 48 CFR 2052.211-70 - Preparation of technical reports.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ....211-70 Preparation of technical reports. As prescribed at 2011.104-70(a), the contracting officer... Reports (JAN 1993) All technical reports required by Section C and all Technical Progress Reports required... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Preparation of technical...

  4. Environmental effects of ozone depletion and its interactions with climate change: progress report, 2015.

    PubMed

    2016-02-01

    The Environmental Effects Assessment Panel (EEAP) is one of three Panels that regularly informs the Parties (countries) to the Montreal Protocol on the effects of ozone depletion and the consequences of climate change interactions with respect to human health, animals, plants, biogeochemistry, air quality, and materials. The Panels provide a detailed assessment report every four years. The most recent 2014 Quadrennial Assessment by the EEAP was published as a special issue of seven papers in 2015 (Photochem. Photobiol. Sci., 2015, 14, 1-184). The next Quadrennial Assessment will be published in 2018/2019. In the interim, the EEAP generally produces an annual update or progress report of the relevant scientific findings. The present progress report for 2015 assesses some of the highlights and new insights with regard to the interactive nature of the effects of UV radiation, atmospheric processes, and climate change.

  5. Toward Active Control of Noise from Hot Supersonic Jets

    DTIC Science & Technology

    2012-05-14

    was developed that would allow for easy data sharing among the research teams. This format includes the acoustic data along with all calibration ...SUPERSONIC | QUARTERLY RPT. 3 ■ 1 i; ’XZ. "• Tff . w w i — r i (a) Far-Field Array Calibration (b) MHz Rate PIV Camera Setup Figure... Plenoptic camera is a similar setup to determine 3-D motion of the flow using a thick light sheet. 2.3 Update on CFD Progress In the previous interim

  6. Implementing Program Integrity from an HBCU Perspective: Progress, Problems, and Prospects. An Analysis of Part H, Program Integrity - TRIAD of the Higher Education Act and the Final Rules and Related Interim Final Regulations Published in the "Federal Register" on April 29, 1994.

    ERIC Educational Resources Information Center

    Blakely, William A.

    This paper examines the impact and implications for the nation's 104 historically black colleges and universities (HBCUs) of the final regulations published in the April 29, 1994 "Federal Register" and traces both the legislative and regulatory history of Part H of the Higher Education Act provisions. The analysis addresses specific…

  7. NRL EIGHTH CARD Program Interim Progress Report, 1 March 1969 to 30 September 1969

    DTIC Science & Technology

    1969-12-31

    methods to measure the water vapor content of the atmosphere have been inves- tigated. One is based on the psychrometer method of measuring wet and dry bulb...over and under configuration. A shipboard psychrometer consisting of the sensors and blower and an 18.5-foot-high intake stack has been mounted on a...small boat. The intake stack may be partially dismounted to pro- vide a 9-foot intake level. The readout for the psychrometer is a multipoint Leeds and

  8. 75 FR 984 - Draft Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at CERCLA and RCRA Sites

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-07

    ... Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at CERCLA and RCRA Sites AGENCY... Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at Comprehensive Environmental Response... interim PRGs for dioxin in soil. These draft recommended interim PRGs were calculated using existing, peer...

  9. Laser ablation/ionization characterization of solids: Second interim progress report of the strategic environmental research development program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hess, W.P.; Bushaw, B.A.; McCarthy, M.I.

    1996-10-01

    The Department of Energy is undertaking the enormous task of remediating defense wastes and environmental insults which have occurred over 50 years of nuclear weapons production. It is abundantly clear that significant technology advances are needed to characterize, process, and store highly radioactive waste and to remediate contaminated zones. In addition to the processing and waste form issues, analytical technologies needed for the characterization of solids, and for monitoring storage tanks and contaminated sites do not exist or are currently expensive labor-intensive tasks. This report describes progress in developing sensitive, rapid, and widely applicable laser-based mass spectrometry techniques for analysismore » of mixed chemical wastes and contaminated soils.« less

  10. Establishing a Quality Control System for Stem Cell-Based Medicinal Products in China

    PubMed Central

    2015-01-01

    Stem cell-based medicinal products (SCMPs) are emerging as novel therapeutic products. The success of its development depends on the existence of an effective quality control system, which is constituted by quality control technologies, standards, reference materials, guidelines, and the associated management system in accordance with regulatory requirements along product lifespan. However, a worldwide, effective quality control system specific for SCMPs is still far from established partially due to the limited understanding of stem cell sciences and lack of quality control technologies for accurately assessing the safety and biological effectiveness of SCMPs before clinical use. Even though, based on the existing regulations and current stem cell sciences and technologies, initial actions toward the goal of establishing such a system have been taken as exemplified by recent development of new “interim guidelines” for governing quality control along development of SCMPs and new development of the associated quality control technologies in China. In this review, we first briefly introduced the major institutions involved in the regulation of cell substrates and therapeutic cell products in China and the existing regulatory documents and technical guidelines used as critical references for developing the new interim guidelines. With focus only on nonhematopoietic stem cells, we then discussed the principal quality attributes of SCMPs as well as our thinking of proper testing approaches to be established with relevant evaluation technologies to ensure all quality requirements of SCMPs along different manufacturing processes and development stages. At the end, some regulatory and technical challenges were also discussed with the conclusion that combined efforts should be taken to promote stem cell regulatory sciences to establish the effective quality control system for SCMPs. PMID:25471126

  11. Determining initial enrichment, burnup, and cooling time of pressurized-water reactor spent fuel assemblies by analyzing passive gamma spectra measured at the Clab interim-fuel storage facility in Sweden

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Favalli, Andrea; Vo, D.; Grogan, Brandon R.

    The purpose of the Next Generation Safeguards Initiative (NGSI)–Spent Fuel (SF) project is to strengthen the technical toolkit of safeguards inspectors and/or other interested parties. The NGSI–SF team is working to achieve the following technical goals more easily and efficiently than in the past using nondestructive assay measurements of spent fuel assemblies: (1) verify the initial enrichment, burnup, and cooling time of facility declaration; (2) detect the diversion or replacement of pins; (3) estimate the plutonium mass [which is also a function of the variables in (1)]; (4) estimate the decay heat; and (5) determine the reactivity of spent fuelmore » assemblies. Since August 2013, a set of measurement campaigns has been conducted at the Central Interim Storage Facility for Spent Nuclear Fuel (Clab), in collaboration with Swedish Nuclear Fuel and Waste Management Company (SKB). One purpose of the measurement campaigns was to acquire passive gamma spectra with high-purity germanium and lanthanum bromide scintillation detectors from Pressurized Water Reactor and Boiling Water Reactor spent fuel assemblies. The absolute 137Cs count rate and the 154Eu/ 137Cs, 134Cs/ 137Cs, 106Ru/ 137Cs, and 144Ce/ 137Cs isotopic ratios were extracted; these values were used to construct corresponding model functions (which describe each measured quantity’s behavior over various combinations of burnup, cooling time, and initial enrichment) and then were used to determine those same quantities in each measured spent fuel assembly. Furthermore, the results obtained in comparison with the operator declared values, as well as the methodology developed, are discussed in detail in the paper.« less

  12. Determining initial enrichment, burnup, and cooling time of pressurized-water reactor spent fuel assemblies by analyzing passive gamma spectra measured at the Clab interim-fuel storage facility in Sweden

    DOE PAGES

    Favalli, Andrea; Vo, D.; Grogan, Brandon R.; ...

    2016-02-26

    The purpose of the Next Generation Safeguards Initiative (NGSI)–Spent Fuel (SF) project is to strengthen the technical toolkit of safeguards inspectors and/or other interested parties. The NGSI–SF team is working to achieve the following technical goals more easily and efficiently than in the past using nondestructive assay measurements of spent fuel assemblies: (1) verify the initial enrichment, burnup, and cooling time of facility declaration; (2) detect the diversion or replacement of pins; (3) estimate the plutonium mass [which is also a function of the variables in (1)]; (4) estimate the decay heat; and (5) determine the reactivity of spent fuelmore » assemblies. Since August 2013, a set of measurement campaigns has been conducted at the Central Interim Storage Facility for Spent Nuclear Fuel (Clab), in collaboration with Swedish Nuclear Fuel and Waste Management Company (SKB). One purpose of the measurement campaigns was to acquire passive gamma spectra with high-purity germanium and lanthanum bromide scintillation detectors from Pressurized Water Reactor and Boiling Water Reactor spent fuel assemblies. The absolute 137Cs count rate and the 154Eu/ 137Cs, 134Cs/ 137Cs, 106Ru/ 137Cs, and 144Ce/ 137Cs isotopic ratios were extracted; these values were used to construct corresponding model functions (which describe each measured quantity’s behavior over various combinations of burnup, cooling time, and initial enrichment) and then were used to determine those same quantities in each measured spent fuel assembly. Furthermore, the results obtained in comparison with the operator declared values, as well as the methodology developed, are discussed in detail in the paper.« less

  13. REACTOR PHYSICS QUARTERLY REPORT JANUARY, FEBRUARY, MARCH 1970

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schmid, L. C.; Clayton, E. D.; Heineman, R. E.

    1970-05-01

    The objective of the Reactor Physics Quarterly Report is to inform the scientific community in a timely manner of the technical progress made on the many phases of reactor physics work within the laboratory. The report contains brief technical discussions of accomplishments in all areas where significant progress has been made during the quarter.

  14. George A. Olah, Carbocation and Hydrocarbon Chemistry

    Science.gov Websites

    . Final Technical Report. [HF:BF{sub 2}/H{sub 2}] , DOE Technical Report, 1980 Superacid Catalyzed Coal Conversion Chemistry. 1st and 2nd Quarterly Technical Progress Reports, September 1, 1983-March 30, 1984 , DOE Technical Report, 1984 Superacid Catalyzed Coal Conversion Chemistry. Final Technical Report

  15. HKHC Community Dashboard: design, development, and function of a Web-based performance monitoring system.

    PubMed

    Bors, Philip A; Kemner, Allison; Fulton, John; Stachecki, Jessica; Brennan, Laura K

    2015-01-01

    As part of Robert Wood Johnson Foundation's Healthy Kids, Healthy Communities (HKHC) national grant program, a technical assistance team designed the HKHC Community Dashboard, an online progress documentation and networking system. The Dashboard was central to HKHC's multimethod program evaluation and became a communication interface for grantees and technical assistance providers. The Dashboard was designed through an iterative process of identifying needs and priorities; designing the user experience, technical development, and usability testing; and applying visual design. The system was created with an open-source content management system and support for building an online community of users. The site developer trained technical assistance providers at the national program office and evaluators, who subsequently trained all 49 grantees. Evaluators provided support for Dashboard users and populated the site with the bulk of its uploaded tools and resource documents. The system tracked progress through an interactive work plan template, regular documentation by local staff and partners, and data coding and analysis by the evaluation team. Other features included the ability to broadcast information to Dashboard users via e-mail, event calendars, discussion forums, private messaging, a resource clearinghouse, a technical assistance diary, and real-time progress reports. The average number of Dashboard posts was 694 per grantee during the grant period. Technical assistance providers and grantees uploaded a total of 1304 resource documents. The Dashboard functions with the highest grantee satisfaction were its interfaces for sharing and progress documentation. A majority of Dashboard users (69%) indicated a preference for continued access to the Dashboard's uploaded resource documents. The Dashboard was a useful and innovative tool for participatory evaluation of a large national grant program. While progress documentation added some burden to local project staff, the system proved to be a useful resource-sharing technology.

  16. Modeling the impacts of climate change and technical progress on the wheat yield in inland China: An autoregressive distributed lag approach.

    PubMed

    Zhai, Shiyan; Song, Genxin; Qin, Yaochen; Ye, Xinyue; Lee, Jay

    2017-01-01

    This study aims to evaluate the impacts of climate change and technical progress on the wheat yield per unit area from 1970 to 2014 in Henan, the largest agricultural province in China, using an autoregressive distributed lag approach. The bounded F-test for cointegration among the model variables yielded evidence of a long-run relationship among climate change, technical progress, and the wheat yield per unit area. In the long run, agricultural machinery and fertilizer use both had significantly positive impacts on the per unit area wheat yield. A 1% increase in the aggregate quantity of fertilizer use increased the wheat yield by 0.19%. Additionally, a 1% increase in machine use increased the wheat yield by 0.21%. In contrast, precipitation during the wheat growth period (from emergence to maturity, consisting of the period from last October to June) led to a decrease in the wheat yield per unit area. In the short run, the coefficient of the aggregate quantity of fertilizer used was negative. Land size had a significantly positive impact on the per unit area wheat yield in the short run. There was no significant short-run or long-run impact of temperature on the wheat yield per unit area in Henan Province. The results of our analysis suggest that climate change had a weak impact on the wheat yield, while technical progress played an important role in increasing the wheat yield per unit area. The results of this study have implications for national and local agriculture policies under climate change. To design well-targeted agriculture adaptation policies for the future and to reduce the adverse effects of climate change on the wheat yield, climate change and technical progress factors should be considered simultaneously. In addition, adaptive measures associated with technical progress should be given more attention.

  17. Modeling the impacts of climate change and technical progress on the wheat yield in inland China: An autoregressive distributed lag approach

    PubMed Central

    Qin, Yaochen; Lee, Jay

    2017-01-01

    This study aims to evaluate the impacts of climate change and technical progress on the wheat yield per unit area from 1970 to 2014 in Henan, the largest agricultural province in China, using an autoregressive distributed lag approach. The bounded F-test for cointegration among the model variables yielded evidence of a long-run relationship among climate change, technical progress, and the wheat yield per unit area. In the long run, agricultural machinery and fertilizer use both had significantly positive impacts on the per unit area wheat yield. A 1% increase in the aggregate quantity of fertilizer use increased the wheat yield by 0.19%. Additionally, a 1% increase in machine use increased the wheat yield by 0.21%. In contrast, precipitation during the wheat growth period (from emergence to maturity, consisting of the period from last October to June) led to a decrease in the wheat yield per unit area. In the short run, the coefficient of the aggregate quantity of fertilizer used was negative. Land size had a significantly positive impact on the per unit area wheat yield in the short run. There was no significant short-run or long-run impact of temperature on the wheat yield per unit area in Henan Province. The results of our analysis suggest that climate change had a weak impact on the wheat yield, while technical progress played an important role in increasing the wheat yield per unit area. The results of this study have implications for national and local agriculture policies under climate change. To design well-targeted agriculture adaptation policies for the future and to reduce the adverse effects of climate change on the wheat yield, climate change and technical progress factors should be considered simultaneously. In addition, adaptive measures associated with technical progress should be given more attention. PMID:28950027

  18. Supply Chain Sustainability Analysis of Whole Algae Hydrothermal Liquefaction and Upgrading

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pegallapati, Ambica Koushik; Dunn, Jennifer B.; Frank, Edward D.

    2015-04-01

    The Department of Energy's Bioenergy Technology Office (BETO) collaborates with a wide range of institutions towards the development and deployment of biofuels and bioproducts. To facilitate this effort, BETO and its partner national laboratories develop detailed techno-economic assessments (TEA) of biofuel production technologies as part of the development of design cases and state of technology (SOT) analyses. A design case is a TEA that outlines a target case for a particular biofuel pathway. It enables preliminary identification of data gaps and research and development needs and provides goals and targets against which technology progress is assessed. On the other hand,more » an SOT analysis assesses progress within and across relevant technology areas based on actual experimental results relative to technical targets and cost goals from design cases and includes technical, economic, and environmental criteria as available. (SOT) analyses. A design case is a TEA that outlines a target case for a particular biofuel pathway. It enables preliminary identification of data gaps and research and development needs and provides goals and targets against which technology progress is assessed. On the other hand, an SOT analysis assesses progress within and across relevant technology areas based on actual experimental results relative to technical targets and cost goals from design cases and includes technical, economic, and environmental criteria as available. (SOT) analyses. A design case is a TEA that outlines a target case for a particular biofuel pathway. It enables preliminary identification of data gaps and research and development needs and provides goals and targets against which technology progress is assessed. On the other hand, an SOT analysis assesses progress within and across relevant technology areas based on actual experimental results relative to technical targets and cost goals from design cases and includes technical, economic, and environmental criteria as available.« less

  19. Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients

    PubMed Central

    2013-01-01

    Background This study is to evaluate the predictive value of FDG-PET (PET) in pediatric and adolescent patients suffering from non-Hodgkin lymphoma (pNHL) in comparison to information provided by conventional imaging methods (CIM). Methods Imaging was performed at baseline and at interim (after 2 cycles of chemotherapy). The response assessment in PET was carried out visually and semi-quantitatively, the latter one by use of percentage decrease in SUVmax from baseline to interim (ΔSUVmax). The PET-based results were compared to the findings by CIM. Progression-free survival (PFS) was analyzed using Kaplan-Meier curves (KM) and log-rank test. Results The final study included 16 patients (mean follow-up time, 60.2 months (range, 4.0 to 85.7 months)). Relapse occurred in four patients. Visual PET compared to CIM revealed higher sensitivity (3/4 vs 1/4) and NPV (6/7 vs 10/13), and equal PPV (3/9 vs 1/3), but lower specificity (6/12 vs 10/12) and accuracy (9/16 vs 11/16). False-positive findings in PET at interim were predominantly observed in patients presenting bulky disease (5/6), whereas CIM was true-negative in all of these cases. KM analyses revealed no significant differences in 5-year PFS neither for CIM (76.9% vs 66.7%; p = 0.67) nor for visual PET (85.7% vs 66.7%; p = 0.34) nor for ΔSUVmax (88.9% vs 57.1%; p = 0.12). Conclusions The predictive value of iPET in pediatric patients suffering from NHL was limited due to considerably high amount of false-positive findings, especially in patients suffering from bulky disease. However, due to our limited sample size, final conclusions cannot be drawn and, thus, call for further evaluation of PET in pNHL in larger and more homogenous patient series. PMID:24139528

  20. Technical Adequacy of Growth Estimates from a Computer Adaptive Test: Implications for Progress Monitoring

    ERIC Educational Resources Information Center

    Van Norman, Ethan R.; Nelson, Peter M.; Parker, David C.

    2017-01-01

    Computer adaptive tests (CATs) hold promise to monitor student progress within multitiered systems of support. However, the relationship between how long and how often data are collected and the technical adequacy of growth estimates from CATs has not been explored. Given CAT administration times, it is important to identify optimal data…

  1. Education, Industrialization and Technical Progress in Mexico. IIEP Research Report No. 6.

    ERIC Educational Resources Information Center

    Padua, Jorge

    This report attempts to analyze the contributions of the educational system and job training programs to industrialization and technical progress in the Conubal zone of the Lower Balsas River of Mexico. The first of the study's three sections consists of two chapters that provide general background. Chapter 1, "Theories of Development and the…

  2. Technical Adequacy and Acceptability of Curriculum-Based Measurement and the Measures of Academic Progress

    ERIC Educational Resources Information Center

    January, Stacy-Ann A.; Ardoin, Scott P.

    2015-01-01

    Curriculum-based measurement in reading (CBM-R) and the Measures of Academic Progress (MAP) are assessment tools widely employed for universal screening in schools. Although a large body of research supports the validity of CBM-R, limited empirical evidence exists supporting the technical adequacy of MAP or the acceptability of either measure for…

  3. Annual Technical Progress Report for Emergency School Assistance Program, Title 45, 1970-71.

    ERIC Educational Resources Information Center

    Lindsey, Randall B.

    This paper presents a technical progress report of two programs conducted with funds provided under the Emergency School Assistance Program. One, the Mobile Learning Unit, said to have been designed to measure changes in fourth and fifth grade students' self-concept in a reorganized desegregated school environment, focuses on whether a positive…

  4. Third Progress and Information Report of the Vocational-Technical Education Consortium of States.

    ERIC Educational Resources Information Center

    Lee, Connie W.; And Others

    This description of major activities and accomplishments of the Vocational-Technical Education Consortium of the States (V-TECS) since the second progress report of May, 1975, is designed to provide the reader with a basic understanding of the processes and procedures used by the consortium in achieving its major goal: The production of catalogs…

  5. A PSFI-based analysis on the energy efficiency potential of China’s domestic passenger vehicles

    NASA Astrophysics Data System (ADS)

    Chen, Chuan; Ren, Huanhuan; Zhao, Dongchang

    2017-01-01

    In this article, China’s domestic passenger vehicles (excluding new energy vehicles) are categorized into two groups: local brand vehicles and vehicles manufactured by joint ventures. Performance-Size-Fuel economy Index (PSFI) will be applied to analyse the speed of technical progress and the future trends of these vehicles. In addition, a forecast on energy efficiency potential of domestic passenger vehicles from 2016 to 2020 will be made based on different Emphasis on Reducing Fuel Consumption (ERFC) scenarios. According to the study, if the process of technical progress continues at its current speed, domestic ICE passenger vehicles will hardly meet Phase IV requirements by 2020 even though companies contribute as much technical progress to fuel consumption reduction as possible.

  6. Advanced Thermal Emission Imaging Systems Definition and Development

    NASA Technical Reports Server (NTRS)

    Blasius, Karl; Nava, David (Technical Monitor)

    2002-01-01

    Santa Barbara Remote Sensing (SBRS), Raytheon Company, is pleased to submit this quarterly progress report of the work performed in the third quarter of Year 2 of the Advanced THEMIS Project, July through September 2002. We review here progress in the proposed tasks. During July through September 2002 progress was made in two major tasks, Spectral Response Characterization and Flight Instrument Definition. Because of staffing problems and technical problems earlier in the program we have refocused the remaining time and budget on the key technical tasks. Current technical problems with a central piece of test equipment has lead us to request a 1 quarter extension to the period of performance. This request is being made through a separate letter independent of this report.

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stout, D.K.

    Flaws are noted in equilibrium growth models which ignore the facts that labor is no longer homogeneous, national governments can no longer guarantee a managed demand, and technical progress is not an independent force. The pace of technical progress is the major variable and increases with competition and certainty in the growth of demand. The outlook for technical progress is examined in the context of productivity, using microprocessor development for illustration. The author takes an optimistic view of new developments in that they do not bring the self-destructive possibility of overpopulation, irreversible damage to the environment, or nuclear war anymore » closer, while having a positive chance to promote a more rewarding relationship between education, work, and life style. The opportunities for positive humanistic changes through microprocessing are confirmed. (DCK)« less

  8. Environmental DNA calibration study. Interim technical review report

    USGS Publications Warehouse

    Baerwaldt, K.; Bartron, Meredith L.; Schilling, K.; Lee, Debbie; Russo, Edmond; Estes, Trudy; Fischer, Richard; Fleming, Beth; Guilfoyle, Michael P.; Kilgore, K. Jack; Lance, Richard; Perkins, Edward; Schultz, Martin; Smith, David; Amberg, Jon J.; Chapman, Duane C.; Gaikowski, Mark P.; Klymus, Katy E.; Richter, Catherine A.

    2014-01-01

    Should a sustainable Asian carp population become established in the Great Lakes, native fish populations, as well as many threatened or endangered plant/animal species populations, could be impacted. In response to this threat, the Asian Carp Regional Control Committee (ACRCC) was formed in part to coordinate efforts to understand and organize against the Asian carp threat. The Asian Carp Control Strategy Framework (2012a) outlined major tasks to be completed for a better understanding of factors related to the advance of Asian carp populations towards the Great Lakes. In addition, the ACRCC formed the Monitoring and Rapid Response Workgroup to address Asian carp monitoring and removal (ACRCC 2012b).

  9. Scientific and Technical Information Policy of the Federal Republic of Germany

    NASA Astrophysics Data System (ADS)

    Tamura, Koji

    The gist and the background of “Specialized Information Program 1985-1988”, which was decided by the Federal government of Germany in June 1985, were outlined in comparison with the interim report of the fiscal year 1986. In the previous program “I & D” from 1974 to 1977, the establishment of GID (Association for Information and Documentation) and the consolidation of Specialized Information Centers (FIZ) were main object. However, in the new program, the role sharing between government and private enterprises was emphasized with a view to stimulate information demand in the circumstance of cooperation and competition of the world market.

  10. Index to Nuclear Safety. A technical progress review by chronology, permuted title, and author. Vol. 11, No. 1--Vol. 17, No. 6

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cottrell, W.B.; Klein, A.

    1977-02-23

    This index to Nuclear Safety covers articles in Nuclear Safety Vol. 11, No. 1 (Jan.-Feb. 1970), through Vol. 17, No. 6 (Nov.-Dec. 1976). The index includes a chronological list of articles (including abstract) followed by KWIC and Author Indexes. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. The index lists over 350 technical articles in the last six years of publication.

  11. A web-based endpoint adjudication system for interim analyses in clinical trials.

    PubMed

    Nolen, Tracy L; Dimmick, Bill F; Ostrosky-Zeichner, Luis; Kendrick, Amy S; Sable, Carole; Ngai, Angela; Wallace, Dennis

    2009-02-01

    A data monitoring committee (DMC) is often employed to assess trial progress and review safety data and efficacy endpoints throughout a trail. Interim analyses performed for the DMC should use data that are as complete and verified as possible. Such analyses are complicated when data verification involves subjective study endpoints or requires clinical expertise to determine each subject's status with respect to the study endpoint. Therefore, procedures are needed to obtain adjudicated data for interim analyses in an efficient manner. In the past, methods for handling such data included using locally reported results as surrogate endpoints, adjusting analysis methods for unadjudicated data, or simply performing the adjudication as rapidly as possible. These methods all have inadequacies that make their sole usage suboptimal. For a study of prophylaxis for invasive candidiasis, adjudication of both study eligibility criteria and clinical endpoints prior to two interim analyses was required. Because the study was expected to enroll at a moderate rate and the sponsor required adjudicated endpoints to be used for interim analyses, an efficient process for adjudication was required. We created a web-based endpoint adjudication system (WebEAS) that allows for expedited review by the endpoint adjudication committee (EAC). This system automatically identifies when a subject's data are complete, creates a subject profile from the study data, and assigns EAC reviewers. The reviewers use the WebEAS to review the subject profile and submit their completed review form. The WebEAS then compares the reviews, assigns an additional review as a tiebreaker if needed, and stores the adjudicated data. The study for which this system was originally built was administratively closed after 10 months with only 38 subjects enrolled. The adjudication process was finalized and the WebEAS system activated prior to study closure. Some website accessibility issues presented initially. However, once these issues were resolved, the reviewers found the system user-friendly and easy to navigate. Web-based data adjudication depends upon expeditious data collection and verification. Further, ability to use web-based technologies, in addition to clinical expertise, must be considered in selecting EAC members. The automated nature of this system makes it a practical mechanism for ensuring timely endpoint adjudication. The authors believe a similar approach could be useful for handling endpoint adjudication for future clinical trials.

  12. Modeling and simulation of maintenance treatment in first-line non-small cell lung cancer with external validation.

    PubMed

    Han, Kelong; Claret, Laurent; Sandler, Alan; Das, Asha; Jin, Jin; Bruno, Rene

    2016-07-13

    Maintenance treatment (MTx) in responders following first-line treatment has been investigated and practiced for many cancers. Modeling and simulation may support interpretation of interim data and development decisions. We aimed to develop a modeling framework to simulate overall survival (OS) for MTx in NSCLC using tumor growth inhibition (TGI) data. TGI metrics were estimated using longitudinal tumor size data from two Phase III first-line NSCLC studies evaluating bevacizumab and erlotinib as MTx in 1632 patients. Baseline prognostic factors and TGI metric estimates were assessed in multivariate parametric models to predict OS. The OS model was externally validated by simulating a third independent NSCLC study (n = 253) based on interim TGI data (up to progression-free survival database lock). The third study evaluated pemetrexed + bevacizumab vs. bevacizumab alone as MTx. Time-to-tumor-growth (TTG) was the best TGI metric to predict OS. TTG, baseline tumor size, ECOG score, Asian ethnicity, age, and gender were significant covariates in the final OS model. The OS model was qualified by simulating OS distributions and hazard ratios (HR) in the two studies used for model-building. Simulations of the third independent study based on interim TGI data showed that pemetrexed + bevacizumab MTx was unlikely to significantly prolong OS vs. bevacizumab alone given the current sample size (predicted HR: 0.81; 95 % prediction interval: 0.59-1.09). Predicted median OS was 17.3 months and 14.7 months in both arms, respectively. These simulations are consistent with the results of the final OS analysis published 2 years later (observed HR: 0.87; 95 % confidence interval: 0.63-1.21). Final observed median OS was 17.1 months and 13.2 months in both arms, respectively, consistent with our predictions. A robust TGI-OS model was developed for MTx in NSCLC. TTG captures treatment effect. The model successfully predicted the OS outcomes of an independent study based on interim TGI data and thus may facilitate trial simulation and interpretation of interim data. The model was built based on erlotinib data and externally validated using pemetrexed data, suggesting that TGI-OS models may be treatment-independent. The results supported the use of longitudinal tumor size and TTG as endpoints in early clinical oncology studies.

  13. 5 CFR 772.102 - Interim personnel actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Interim personnel actions. 772.102 Section 772.102 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) INTERIM RELIEF General § 772.102 Interim personnel actions. When an employee or...

  14. 5 CFR 772.102 - Interim personnel actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Interim personnel actions. 772.102 Section 772.102 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) INTERIM RELIEF General § 772.102 Interim personnel actions. When an employee or...

  15. [Address Given at the Regional Junior College Recreation Education Institute, American River College, September 25, 1969.

    ERIC Educational Resources Information Center

    Lutzin, Sidney G.

    The United States has made striking technical advances in recent years, but there has not been comparable progress in social services. Greater affluence and leisure for some have been one result of technical progress, but problems of poverty and urban development are more pressing. New developments to improve the condition of society can be…

  16. THE DEVELOPMENT OF PRE-VOCATIONAL EDUCATION LITERACY COURSES FOR USE WITH COMPUTER ASSISTED INSTRUCTION OF DISADVANTAGED YOUTH AND ADULTS. TECHNICAL PROGRESS REPORT.

    ERIC Educational Resources Information Center

    HANKIN, EDWARD K.; AND OTHERS

    THIS TECHNICAL PROGRESS REPORT COVERS THE FIRST THREE MONTHS OF A PROJECT TO DEVELOP COMPUTER ASSISTED PREVOCATIONAL READING AND ARITHMETIC COURSES FOR DISADVANTAGED YOUTHS AND ADULTS. DURING THE FIRST MONTH OF OPERATION, PROJECT PERSONNEL CONCENTRATED ON SUCH ADMINISTRATIVE MATTERS AS TRAINING STAFF AND PREPARING FACILITIES. AN ARITHMETIC PROGRAM…

  17. Generation and focusing of pulsed intense ion beams. Technical progress report, 20 August 1981-30 September 1982

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hammer, D.A.; Kusse, B.R.; Sudan, R.N.

    1983-07-01

    The progress on this contract is described in two parts. The first deals with the technical operation of the LION accelerator which is the exact equivalent to one line of PBFA-I. The second part is concerned with the experimental results on the ion diode mounted at the front end of the LION accelerator.

  18. Project LIFE--Language Improvement to Facilitate Education. (Technical Progress Report; Third Quarter; March 1, 1974-May 31, 1974).

    ERIC Educational Resources Information Center

    National Foundation for the Improvement of Education, Washington, DC.

    Reported is the third quarter, fiscal year 1974 (March 1, 1974-May 31, 1974) technical progress of Project LIFE (Language Improvement to Facilitate Education), toward developing an instructional system in which filmstrips in the areas of perceptual training, perceptual thinking, and language/reading are used to assist hearing impaired children in…

  19. Interim Expertise

    ERIC Educational Resources Information Center

    Anyaso, Hilary Hurd

    2009-01-01

    The Registry for College and University Presidents places former executives in interim presidential and other senior-level posts and is familiar with the challenges interim executives and institutions encounter in times of leadership transitions. However, the one big advantage interims bring to institutions, says Registry Vice President Kevin J.…

  20. 40 CFR 155.56 - Interim registration review decision.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Interim registration review decision... PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures § 155.56 Interim registration review decision. The Agency may issue, when it determines it to be appropriate, an interim...

  1. Monitoring the Durability Performance of Concrete in Nuclear Waste Containment. Technical Progress Report No. 4

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ulm, Franz-Josef

    2000-06-30

    OAK-B135 Monitoring the Durability Performance of Concrete in Nuclear Waste Containment. Technical Progress Report No. 4. The analysis of the effect of cracks on the acceleration of the calcium leaching process of cement-based materials has been pursued. During the last period (Technical Progress Report No 3), we have introduced a modeling accounting for the high diffusivity of fractures in comparison with the weak solid material diffusivity. It has been shown through dimensional and asymptotic analysis that small fractures do not significantly accelerate the material aging process. This important result for the overall structural aging kinetics of containment structure has beenmore » developed in a paper submitted to the international journal ''Transport in Porous Media''.« less

  2. 17 CFR 210.8-03 - Interim financial statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (§ 249.308(a) of this chapter) must be reviewed by an independent public accountant using professional... interim financial statements have been reviewed by an independent public accountant, a report of the accountant on the review must be filed with the interim financial statements. Interim financial statements...

  3. 24 CFR 35.1330 - Interim controls.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Interim controls. 35.1330 Section... Lead-Paint Hazard Evaluation and Hazard Reduction Activities § 35.1330 Interim controls. Interim controls of lead-based paint hazards identified in a risk assessment shall be conducted in accordance with...

  4. 7 CFR 1738.21 - Interim financing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Interim financing. 1738.21 Section 1738.21... Interim financing. (a) Upon notification by RUS that an applicant's application is considered complete, the applicant may enter into an interim financing agreement with a lender other than RUS or use its...

  5. Application of the ALE and MBE Methods to the Growth of Layered Hg sub x Cd sub 1-x Te Films.

    DTIC Science & Technology

    1986-09-26

    films / We have studied the applicability of the Atomic Layer Epitaxy (ALE, vee Ref. -1pand Molecular Beam Epitaxy (MBE) ito growth of Hg2 Cdi- ,Te...thin- films throughout the composition range 0 x $ 0.8. The progress of the Contract has been reported periodically in five interim reports. This final...I separate sources) yielded films with high x values. On the grounds of these observations we do not find ALE suitable for growth of HgCdTe. 2) ALE

  6. Radioactive Wastes.

    PubMed

    Choudri, B S; Charabi, Yassine; Baawain, Mahad; Ahmed, Mushtaque

    2017-10-01

    Papers reviewed herein present a general overview of radioactive waste related activities around the world in 2016. The current reveiw include studies related to safety assessments, decommission and decontamination of nuclear facilities, fusion facilities, transportation. Further, the review highlights on management solutions for the final disposal of low and high level radioactive wastes (LLW and HLW), interim storage and final disposal options for spent fuel (SF), and tritiated wastes, with a focus on environmental impacts due to the mobility of radionuclides in ecosystem, water and soil alongwith other progress made in the management of radioactive wastes.

  7. 47 CFR 51.611 - Interim wholesale rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... selecting a particular discount rate. The same discount percentage rate shall be used to establish interim... 47 Telecommunication 3 2010-10-01 2010-10-01 false Interim wholesale rates. 51.611 Section 51.611... Resale § 51.611 Interim wholesale rates. (a) If a state commission cannot, based on the information...

  8. 7 CFR 15a.71 - Interim procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Interim procedures. 15a.71 Section 15a.71 Agriculture Office of the Secretary of Agriculture EDUCATION PROGRAMS OR ACTIVITIES RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Procedures (Interim) § 15a.71 Interim procedures. For the purposes of...

  9. 77 FR 55230 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-01; Compliance With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0068] Japan Lessons-Learned Project Directorate Interim... Commission (NRC). ACTION: Japan Lessons-Learned Project Directorate interim staff guidance; issuance. SUMMARY...-Learned Project Directorate Interim Staff Guidance (JLD-ISG), JLD-ISG-2012-01, ``Compliance with Order EA...

  10. 77 FR 55231 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-02; Compliance With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0069] Japan Lessons-Learned Project Directorate Interim...-Learned Project Directorate interim staff guidance; issuance. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the Commission) is issuing the Final Japan Lessons-Learned Project Directorate Interim...

  11. 7 CFR 1735.75 - Interim financing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Interim financing. 1735.75 Section 1735.75... Involving Loan Funds § 1735.75 Interim financing. (a) A borrower may submit a written request for RUS approval of interim financing if it is necessary to close an acquisition before the loan to finance the...

  12. 13 CFR 120.890 - Source of interim financing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

  13. 13 CFR 120.890 - Source of interim financing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

  14. 13 CFR 120.890 - Source of interim financing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

  15. 13 CFR 120.890 - Source of interim financing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

  16. 13 CFR 120.890 - Source of interim financing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Interim Financing § 120.890 Source of interim financing. A Project may... experience or qualifications, SBA may require the interim loan to be managed by a third party such as a bank...

  17. Department of Clinical Investigation Annual Research Progress Report, Fiscal Year 1984. Volume 1,

    DTIC Science & Technology

    1984-10-01

    on a low dosage of medication . Technical Approach: None. Progress: The placebo has not been received from the company. Since the drug company...determine the effect of high dose Ar-C intensification therapy on the -. incidence of CNS relapse. - Technical Approach: All patients with a new...Enrolled to Date: 7 Date of Periodic Review Results Objective(s): To determine the incidence of

  18. Total Factor Productivity Growth, Technical Progress & Efficiency Change in Vietnam Coal Industry - Nonparametric Approach

    NASA Astrophysics Data System (ADS)

    Phuong, Vu Hung

    2018-03-01

    This research applies Data Envelopment Analysis (DEA) approach to analyze Total Factor Productivity (TFP) and efficiency changes in Vietnam coal mining industry from 2007 to 2013. The TFP of Vietnam coal mining companies decreased due to slow technological progress and unimproved efficiency. The decadence of technical efficiency in many enterprises proved that the coal mining industry has a large potential to increase productivity through technical efficiency improvement. Enhancing human resource training, technology and research & development investment could help the industry to improve efficiency and productivity in Vietnam coal mining industry.

  19. 12 CFR 552.2-2 - Procedures for organization of interim Federal stock association.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Procedures for organization of interim Federal stock association. (a) Applications for permission to organize... chapter or § 552.2-1(b)(3) of this part. (b) Approval of an application for permission to organize an... the interim was chartered to facilitate. Applications for permission to organize an interim Federal...

  20. DOUBLE TRACKS Test Site interim corrective action plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    The DOUBLE TRACKS site is located on Range 71 north of the Nellis Air Force Range, northwest of the Nevada Test Site (NTS). DOUBLE TRACKS was the first of four experiments that constituted Operation ROLLER COASTER. On May 15, 1963, weapons-grade plutonium and depleted uranium were dispersed using 54 kilograms of trinitrotoluene (TNT) explosive. The explosion occurred in the open, 0.3 m above the steel plate. No fission yield was detected from the test, and the total amount of plutonium deposited on the ground surface was estimated to be between 980 and 1,600 grams. The test device was composed primarilymore » of uranium-238 and plutonium-239. The mass ratio of uranium to plutonium was 4.35. The objective of the corrective action is to reduce the potential risk to human health and the environment and to demonstrate technically viable and cost-effective excavation, transportation, and disposal. To achieve these objectives, Bechtel Nevada (BN) will remove soil with a total transuranic activity greater then 200 pCI/g, containerize the soil in ``supersacks,`` transport the filled ``supersacks`` to the NTS, and dispose of them in the Area 3 Radioactive Waste Management Site. During this interim corrective action, BN will also conduct a limited demonstration of an alternative method for excavation of radioactive near-surface soil contamination.« less

  1. 48 CFR 2011.104-70 - NRC Clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

  2. 48 CFR 2011.104-70 - NRC Clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

  3. 48 CFR 2011.104-70 - NRC Clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

  4. 48 CFR 2011.104-70 - NRC Clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

  5. 48 CFR 2011.104-70 - NRC Clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

  6. 32 CFR 203.17 - Technical assistance provider reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

  7. 32 CFR 203.17 - Technical assistance provider reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

  8. 32 CFR 203.17 - Technical assistance provider reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

  9. 32 CFR 203.17 - Technical assistance provider reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

  10. 32 CFR 203.17 - Technical assistance provider reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Technical assistance provider reporting requirements. 203.17 Section 203.17 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY... technical assistance provider shall submit progress reports, financial status reports, materials prepared...

  11. 76 FR 14559 - Federal Acquisition Regulation; Justification and Approval of Sole-Source 8(a) Contracts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... Space Administration (NASA). ACTION: Interim rule. SUMMARY: DoD, GSA, and NASA are issuing an interim..., and NASA are issuing an interim rule amending the FAR, to implement section 811 of the National... meetings, DoD, GSA, and NASA weighed the costs and benefits of publishing this rule as proposed or interim...

  12. Interim Administrators in Higher Education: A National Study

    ERIC Educational Resources Information Center

    Huff, Marie Thielke; Neubrander, Judy

    2015-01-01

    The focus of this paper is on the roles and experiences of interim administrators in higher education. A survey was given to current and recent interim administrators in four-year public universities and colleges across the United States. The goals were to identify the advantages and disadvantages of using and serving as interims, and to solicit…

  13. ISABELLE: a progress report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hahn, H

    This paper discusses the ISABELLE project, which has the objective of constructing a high-energy proton colliding beam facility at Brookhaven National Laboratory. The major technical features of the intersecting storage accelerators with their projected performance are described. Application of over 1000 superconducting magnets in the two rings represents the salient characteristic of the machine. The status of the entire project, the technical progress made so far, and difficulties encountered are reviewed.

  14. Final Technical Progress Report: Development of Low-Cost Suspension Heliostat; December 7, 2011 - December 6, 2012

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bender, W.

    2013-01-01

    Final technical progress report of SunShot Incubator Solaflect Energy. The project succeeded in demonstrating that the Solaflect Suspension Heliostat design is viable for large-scale CSP installations. Canting accuracy is acceptable and is continually improving as Solaflect improves its understanding of this design. Cost reduction initiatives were successful, and there are still many opportunities for further development and further cost reduction.

  15. 78 FR 52680 - Amendment to the International Traffic in Arms Regulations: Registration and Licensing of Brokers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ...The Department of State is issuing this interim final rule amending the International Traffic in Arms Regulations (ITAR) relating to brokers and brokering activities and to related provisions of the ITAR. These amendments clarify registration requirements, the scope of brokering activities, prior approval requirements and exemptions, procedures for obtaining prior approval and guidance, and reporting and recordkeeping of such activities. Conforming and technical changes are made to other parts of the ITAR that affect export as well as brokering activities. The revisions contained in this rule are part of the Department of State's retrospective plan under E.O. 13563 completed on August 17, 2011.

  16. Measurement of solids motion in gas-fluidized beds. Technical progress report, 1 October 1982-31 December 1982

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, M.M.; Chao, B.T.

    This technical progress report covers the progress made during the fifth quarter of the project entitled Measurements of Solids Motion in Gas Fluidized Beds under Grant No. DOE-F22-81PC40804 during the period 1 October through 31 December 1982. The research concerns the measurement of solids particle velocity distribution and residence time distribution using the Computer-Aided Particle Tracking Facility (CAPTF) at the University of Illinois at Urbana-Champaign. The experimental equipment and measuring methods used to determine particle size distribution and particle motion and the results obtained are presented.

  17. The 1996 NAEP Technical Report.

    ERIC Educational Resources Information Center

    Allen, Nancy L.; Carlson, James E.; Zelenak, Christine A.

    This report documents the design, administration, and data analysis procedure of the National Assessment of Education Progress (NAEP) for 1996. It indicates the technical decisions that were made and the rationale behind them. Detailed substantive findings are not presented in this report. These chapters provide technical information about the…

  18. Lincoln County nuclear waste project. Quarterly progress report, October 1, 1991--December 31, 1991

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-03-01

    This document included the following three progress reports to the Yucca Mountain Project Office on radioactive waste storage in Lincoln County, Nevada: financial status report; federal cash transactions report; and technical progress report.

  19. Lincoln County nuclear waste project. Quarterly progress report, January 1, 1992--March 31, 1992

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-03-01

    This document included the following three progress reports to the Yucca Mountain Project Office on radioactive waste storage in Lincoln County, Nevada: financial status report; federal cash transactions report; and technical progress report.

  20. Lincoln County nuclear waste project quarterly progress report, April 1, 1992--June 30, 1992

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-03-01

    This document included the following three progress reports to the Yucca Mountain Project Office on radioactive waste storage in Lincoln County, Nevada: financial status report; federal cash transactions report; and technical progress report.

  1. Index to Nuclear Safety: a technical progress review by chronology, permuted title, and author, Volume 18 (1) through Volume 22 (6)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cottrell, W.B.; Passiakos, M.

    This index to Nuclear Safety covers articles published in Nuclear Safety, Volume 18, Number 1 (January-February 1977) through Volume 22, Number 6 (November-December 1981). The index is divided into three section: a chronological list of articles (including abstracts), a permuted-title (KWIC) index, and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. Over 300 technical articles published in Nuclear Safety in the last 5 years are listed in this index.

  2. 77 FR 16250 - Notice of Proposed Information Collection for Public Comment; Office of Native American Programs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... Information Collection for Public Comment; Office of Native American Programs (ONAP) Training and Technical... subject proposal. The data required by Office of Native American Programs Training and Technical... progress. The data identifies needs, outputs and outcomes of the training and technical assistance. DATES...

  3. Social inequalities in the face of scientific and technological development: an antinomy or an historic problem?

    PubMed

    Delgado, Guilherme Costa

    2017-07-01

    This paper aims to conduct a conceptual analysis of the relationship between scientific and technical progress and social equality, or the reduction of inequalities. We examine this relationship by drawing on three theoretical perspectives: 1) ethical economics, championed by classical economic thinkers and centered on utilitarian self-interest, 2) Mainstream theories of economic development espousing the endogenous link between labor productivity growth and technical progress, 3) the critique of theories of economic development that emerged in the second half of the twentieth century, including Celso Furtado's critique of the theory of underdevelopment, emphasizing the prevalence of egalitarian tendencies, and ecological economics, which suggest alternative paths to those set by "classical" theories of development. The fundamental antinomy posed by the title of this article, characterized by an intrinsic contradiction between technical progress and social equality, strictly presupposes the ethical economics perspective, dominated by the social relations that constitute the "social order".

  4. 42 CFR 418.307 - Periodic interim payments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (CONTINUED) MEDICARE PROGRAM HOSPICE CARE Payment for Hospice Care § 418.307 Periodic interim payments... payments. The biweekly interim payment amount is based on the total estimated Medicare payments for the...

  5. Summary of a Gas Transport Tracer Test in the Deep Cerros Del Rio Basalts, Mesita del Buey, Los Alamos NM.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stauffer, Philip H.; Rahn, Thomas A.; Ortiz, John Philip

    Here we describe results from a tracer test in the Cerros del Rio basalt beneath Mesita del Buey, Technical Area 54 (TA-54) at Los Alamos National Laboratory (LANL or the Laboratory). This report follows from plans outlined in our previous Tracer Test Work Plan (LANL 2016). These activities were conducted by LANL to further characterize subsurface properties of the Cerros del Rio basalts at Material Disposal Area (MDA) L (Figure 1.1-1). The work presented follows from the “Interim Measures Work Plan for Soil-Vapor Extraction of Volatile Organic Compounds from Material Disposal Area L, Technical Area 54, Revision 1,” submitted tomore » the New Mexico Environment Department (NMED) in September 2014 (LANL 2014). Remediation of the MDA L vapor plume by soil-vapor extraction (SVE) is recommended as part of the final remedy in the “Corrective Measures Evaluation Report for Material Disposal Area L, Solid Waste Management Unit 54-006, at Technical Area 54, Revision 2” to meet a remedial action objective of preventing groundwater from being impacted above a regulatory standard by the transport of volatile organic compounds (VOCs) to groundwater through soil vapor (LANL 2011).« less

  6. NASA Electronic Library System (NELS) optimization

    NASA Technical Reports Server (NTRS)

    Pribyl, William L.

    1993-01-01

    This is a compilation of NELS (NASA Electronic Library System) Optimization progress/problem, interim, and final reports for all phases. The NELS database was examined, particularly in the memory, disk contention, and CPU, to discover bottlenecks. Methods to increase the speed of NELS code were investigated. The tasks included restructuring the existing code to interact with others more effectively. An error reporting code to help detect and remove bugs in the NELS was added. Report writing tools were recommended to integrate with the ASV3 system. The Oracle database management system and tools were to be installed on a Sun workstation, intended for demonstration purposes.

  7. Software Safety Progress in NASA

    NASA Technical Reports Server (NTRS)

    Radley, Charles F.

    1995-01-01

    NASA has developed guidelines for development and analysis of safety-critical software. These guidelines have been documented in a Guidebook for Safety Critical Software Development and Analysis. The guidelines represent a practical 'how to' approach, to assist software developers and safety analysts in cost effective methods for software safety. They provide guidance in the implementation of the recent NASA Software Safety Standard NSS-1740.13 which was released as 'Interim' version in June 1994, scheduled for formal adoption late 1995. This paper is a survey of the methods in general use, resulting in the NASA guidelines for safety critical software development and analysis.

  8. Structural Tailoring of Advanced Turboprops (STAT)

    NASA Technical Reports Server (NTRS)

    Brown, Kenneth W.

    1988-01-01

    This interim report describes the progress achieved in the structural Tailoring of Advanced Turboprops (STAT) program which was developed to perform numerical optimizations on highly swept propfan blades. The optimization procedure seeks to minimize an objective function, defined as either direct operating cost or aeroelastic differences between a blade and its scaled model, by tuning internal and external geometry variables that must satisfy realistic blade design constraints. This report provides a detailed description of the input, optimization procedures, approximate analyses and refined analyses, as well as validation test cases for the STAT program. In addition, conclusions and recommendations are summarized.

  9. Hybrid Wing-Body (HWB) Pressurized Fuselage Modeling, Analysis, and Design for Weight Reduction

    NASA Technical Reports Server (NTRS)

    Mukhopadhyay, Vivek

    2012-01-01

    This paper describes the interim progress for an in-house study that is directed toward innovative structural analysis and design of next-generation advanced aircraft concepts, such as the Hybrid Wing-Body (HWB) and the Advanced Mobility Concept-X flight vehicles, for structural weight reduction and associated performance enhancement. Unlike the conventional, skin-stringer-frame construction for a cylindrical fuselage, the box-type pressurized fuselage panels in the HWB undergo significant deformation of the outer aerodynamic surfaces, which must be minimized without significant structural weight penalty. Simple beam and orthotropic plate theory is first considered for sizing, analytical verification, and possible equivalent-plate analysis with appropriate simplification. By designing advanced composite stiffened-shell configurations, significant weight reduction may be possible compared with the sandwich and ribbed-shell structural concepts that have been studied previously. The study involves independent analysis of the advanced composite structural concepts that are presently being developed by The Boeing Company for pressurized HWB flight vehicles. High-fidelity parametric finite-element models of test coupons, panels, and multibay fuselage sections, were developed for conducting design studies and identifying critical areas of potential failure. Interim results are discussed to assess the overall weight/strength advantages.

  10. Interim Report: 100-NR-2 Apatite Treatability Test: Low Concentration Calcium Citrate-Phosphate Solution Injection for In Situ Strontium-90 Immobilization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Williams, Mark D.; Fritz, Brad G.; Mendoza, Donaldo P.

    2008-07-11

    Following an evaluation of potential Sr-90 treatment technologies and their applicability under 100-NR-2 hydrogeologic conditions, U.S. Department of Energy, Fluor Hanford, Inc., Pacific Northwest National Laboratory, and the Washington Department of Ecology agreed that the long-term strategy for groundwater remediation at 100-N Area will include apatite sequestration as the primary treatment, followed by a secondary treatment if necessary (most likely phytoremediation). Since then, the agencies have worked together to agree on which apatite sequestration technology has the greatest chance of reducing Sr-90 flux to the river at a reasonable cost. In July 2005, aqueous injection, (i.e., the introduction of apatite-formingmore » chemicals into the subsurface) was endorsed as the interim remedy and selected for field testing. Studies are in progress to assess the efficacy of in situ apatite formation by aqueous solution injection to address both the vadose zone and the shallow aquifer along the 300 ft of shoreline where Sr-90 concentrations are highest. This report describes the field testing of the shallow aquifer treatment.« less

  11. Developments in Technical Education in the British Caribbean, 1940-60.

    ERIC Educational Resources Information Center

    Pemberton, S. Macpherson

    The paper discusses developments in technical education in the British West Indies from 1940-1960 emphasizing the relation between education and economic development. The objective is to analyze the economic basis of progress in technical education. The document is presented in four chapters. Chapter I summarizes historical background prior to…

  12. Programs of Study: Year 2 Joint Technical Report. Research Snapshot

    ERIC Educational Resources Information Center

    National Research Center for Career and Technical Education, 2010

    2010-01-01

    In January 2010, the National Research Center for Career and Technical Education (NRCCTE) issued a progress report on three studies being conducted by the Center that examine the implementation and outcomes of Programs of Study (POS), which were required in the 2006 reauthorization of the federal legislation for career and technical education…

  13. Replacement of a hopeless maxillary central incisor: a technique for the fabrication of an immediate implant-supported interim restoration.

    PubMed

    Graiff, Lorenzo; Vigolo, Paolo

    2012-04-01

    Placement of a dental implant and an interim restoration in the esthetic zone immediately following tooth extraction is now a common procedure. However, in such clinical situations, the fabrication of an appropriate interim restoration may be challenging. The aim of this article is to present a technique for modifying the extracted tooth so it can be used as an implant-supported interim restoration.

  14. Recruitment failure and futility were the most common reasons for discontinuation of clinical drug trials. Results of a nationwide inception cohort study in the Netherlands.

    PubMed

    van den Bogert, Cornelis A; Souverein, Patrick C; Brekelmans, Cecile T M; Janssen, Susan W J; Koëter, Gerard H; Leufkens, Hubert G M; Bouter, Lex M

    2017-08-01

    The objective of the study was to identify the reasons for discontinuation of clinical drug trials and to evaluate whether efficacy-related discontinuations were adequately planned in the trial protocol. All clinical drug trials in the Netherlands, reviewed by institutional review boards in 2007, were followed until December 2015. Data were obtained through the database of the Dutch competent authority (Central Committee on Research Involving Human Subjects [CCMO]) and a questionnaire to the principal investigators. Reasons for trial discontinuation were the primary outcome of the study. Three reasons for discontinuation were analyzed separately: all cause, recruitment failure, and efficacy related (when an interim analysis had demonstrated futility or superiority). Among the efficacy-related discontinuations, we examined whether the data monitoring committee, the stopping rule, and the moment of the interim analysis in the trial progress were specified in the trial protocol. Of the 574 trials, 102 (17.8%) were discontinued. The most common reasons were recruitment failure (33 of 574; 5.7%) and solely efficacy related (30 of 574; 5.2%). Of the efficacy-related discontinuations, 10 of 30 (33.3%) of the trial protocols reported all three aspects in the trial protocol, and 20 of 30 (66.7%) reported at least one aspect in the trial protocol. One out of five clinical drug trials is discontinued before the planned trial end, with recruitment failure and futility as the most common reasons. The target sample size of trials should be feasible, and interim analyses should be adequately described in trial protocols. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. International validation study for interim PET in ABVD-treated, advanced-stage hodgkin lymphoma: interpretation criteria and concordance rate among reviewers.

    PubMed

    Biggi, Alberto; Gallamini, Andrea; Chauvie, Stephane; Hutchings, Martin; Kostakoglu, Lale; Gregianin, Michele; Meignan, Michel; Malkowski, Bogdan; Hofman, Michael S; Barrington, Sally F

    2013-05-01

    At present, there are no standard criteria that have been validated for interim PET reporting in lymphoma. In 2009, an international workshop attended by hematologists and nuclear medicine experts in Deauville, France, proposed to develop simple and reproducible rules for interim PET reporting in lymphoma. Accordingly, an international validation study was undertaken with the primary aim of validating the prognostic role of interim PET using the Deauville 5-point score to evaluate images and with the secondary aim of measuring concordance rates among reviewers using the same 5-point score. This paper focuses on the criteria for interpretation of interim PET and on concordance rates. A cohort of advanced-stage Hodgkin lymphoma patients treated with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) were enrolled retrospectively from centers worldwide. Baseline and interim scans were reviewed by an international panel of 6 nuclear medicine experts using the 5-point score. Complete scan datasets of acceptable diagnostic quality were available for 260 of 440 (59%) enrolled patients. Independent agreement among reviewers was reached on 252 of 260 patients (97%), for whom at least 4 reviewers agreed the findings were negative (score of 1-3) or positive (score of 4-5). After discussion, consensus was reached in all cases. There were 45 of 260 patients (17%) with positive interim PET findings and 215 of 260 patients (83%) with negative interim PET findings. Thirty-three interim PET-positive scans were true-positive, and 12 were false-positive. Two hundred three interim PET-negative scans were true-negative, and 12 were false-negative. Sensitivity, specificity, and accuracy were 0.73, 0.94, and 0.91, respectively. Negative predictive value and positive predictive value were 0.94 and 0.73, respectively. The 3-y failure-free survival was 83%, 28%, and 95% for the entire population and for interim PET-positive and -negative patients, respectively (P < 0.0001). The agreement between pairs of reviewers was good or very good, ranging from 0.69 to 0.84 as measured with the Cohen kappa. Overall agreement was good at 0.76 as measured with the Krippendorf α. The 5-point score proposed at Deauville for reviewing interim PET scans in advanced Hodgkin lymphoma is accurate and reproducible enough to be accepted as a standard reporting criterion in clinical practice and for clinical trials.

  16. Publishing interim results of randomised clinical trials in peer-reviewed journals.

    PubMed

    Counsell, Nicholas; Biri, Despina; Fraczek, Joanna; Hackshaw, Allan

    2017-02-01

    Interim analyses of randomised controlled trials are sometimes published before the final results are available. In several cases, the treatment effects were noticeably different after patient recruitment and follow-up completed. We therefore conducted a literature review of peer-reviewed journals to compare the reported treatment effects between interim and final publications and to examine the magnitude of the difference. We performed an electronic search of MEDLINE from 1990 to 2014 (keywords: 'clinical trial' OR 'clinical study' AND 'random*' AND 'interim' OR 'preliminary'), and we manually identified the corresponding final publication. Where the electronic search produced a final report in which the abstract cited interim results, we found the interim publication. We also manually searched every randomised controlled trial in eight journals, covering a range of impact factors and general medical and specialist publications (1996-2014). All paired articles were checked to ensure that the same comparison between interventions was available in both. In all, 63 studies are included in our review, and the same quantitative comparison was available in 58 of these. The final treatment effects were smaller than the interim ones in 39 (67%) trials and the same size or larger in 19 (33%). There was a marked reduction, defined as a ≥20% decrease in the size of the treatment effect from interim to final analysis, in 11 (19%) trials compared to a marked increase in 3 (5%), p = 0.057. The magnitude of percentage change was larger in trials where commercial support was reported, and increased as the proportion of final events at the interim report decreased in trials where commercial support was reported (interaction p = 0.023). There was no evidence of a difference between trials that stopped recruitment at the interim analysis where this was reported as being pre-specified versus those that were not pre-specified (interaction p = 0.87). Published interim trial results were more likely to be associated with larger treatment effects than those based on the final report. Publishing interim results should be discouraged, in order to have reliable estimates of treatment effects for clinical decision-making, regulatory authority reviews and health economic analyses. Our work should be expanded to include conference publications and manual searches of additional journal publications.

  17. Proceedings: Computer Science and Data Systems Technical Symposium, volume 1

    NASA Technical Reports Server (NTRS)

    Larsen, Ronald L.; Wallgren, Kenneth

    1985-01-01

    Progress reports and technical updates of programs being performed by NASA centers are covered. Presentations in viewgraph form are included for topics in three categories: computer science, data systems and space station applications.

  18. Technical and economic assessment of different options for minor actinide transmutation: the French case

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chabert, C.; Coquelet-Pascal, C.; Saturnin, A.

    Studies have been performed to assess the industrial perspectives of partitioning and transmutation of long-lived elements. These studies were carried out in tight connection with GEN-IV systems development. The results include the technical and economic evaluation of fuel cycle scenarios along with different options for optimizing the processes between the minor actinide transmutation in fast neutron reactors, their interim storage and geological disposal of ultimate waste. The results are analysed through several criteria (impacts on waste, on waste repository, on fuel cycle plants, on radiological exposure of workers, on costs and on industrial risks). These scenario evaluations take place inmore » the French context which considers the deployment of the first Sodium-cooled Fast Reactor (SFR) in 2040. 3 management options of minor actinides have been studied: no transmutation, transmutation in SFR and transmutation in an accelerator-driven system (ADS). Concerning economics the study shows that the cost overrun related to the transmutation process could vary between 5 to 9% in SFR and 26 % in the case of ADS.« less

  19. Magnetic Nanofluid Rare Earth Element Extraction Process Report, Techno Economic Analysis, and Results for Geothermal Fluids

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pete McGrail

    This GDR submission is an interim technical report and raw data files from the first year of testing on functionalized nanoparticles for rare earth element extraction from geothermal fluids. The report contains Rare Earth Element uptake results (percent removal, mg Rare Earth Element/gram of sorbent, distribution coefficient) for the elements of Neodymium, Europium, Yttrium, Dysprosium, and Cesium. A detailed techno economic analysis is also presented in the report for a scaled up geothermal rare earth element extraction process. All rare earth element uptake testing was done on simulated geothermal brines with one rare earth element in each brine. The raremore » earth element uptake testing was conducted at room temperature.« less

  20. Nanomechanics of Actively Controlled Deployable Optics

    NASA Technical Reports Server (NTRS)

    Peterson, Lee D.

    2000-01-01

    This document is the interim, annual report for the research grant entitled "Nanomechanics of Actively Controlled Deployed Optics." It is supported by NASA Langley Research Center Cooperative Agreement NCC-1 -281. Dr. Mark S. Lake is the technical monitor of the research program. This document reports activities for the year 1998, beginning 3/11/1998, and for the year 1999. The objective of this report is to summarize the results and the status of this research. This summary appears in Section 2.0. Complete details of the results of this research have been reported in several papers, publications and theses. Section 3.0 lists these publications and, when available, presents their abstracts. Each publication is available in electronic form from a web site identified in Section 3.0.

  1. Production of aluminum-silicon alloy and ferrosilicon and commercial purity aluminum by the direct reduction process. Second interim technical report, Phase C for the period 1980 April 1-1980 June 30

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bruno, M.J.

    1980-10-01

    Beneficiation of bauxite by high intensity wet magnetic separation to remove Fe and Ti was not successful. Pilot reactor VSR-3 was modified and operated to evaluate the blast-arc reduction process concept. Modifications included a tapered upper shaft section, vertical stroke ram, and CO preheater system. The taper/ram revisions were successful in maintaining bed movement, resulting in several continuous runs in which large quantities of burden were fed and metal product was recovered. Pilot VSR samples were also analyzed. The major phases contained Si and FeSi/sub 2/Al/sub 4/ intermetallics in a matrix of eutectic Al-Si.

  2. Production of aluminum-silicon alloy and ferrosilicon and commercial purity aluminum by the direct reduction process. Third interim technical report, Phase C for the period 1980 July 1-1980 September 30

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bruno, M.J.

    1980-10-01

    Pilot reactor VSR-3 operation in the third quarter was directed to tapping molten alloy product. Modifications to the hearth region included a tapping furnace to maintain taphole temperature, a graphite ring filter to separate carbides from matal and an alumina liner to eliminate carbiding from reaction of alloy with the graphite hearth walls. Tapping was not successful, however, due to high alloy viscosity from a large concentration of carbides. Three runs were made on the pilot crystallizer to determine the effects of alloy composition, cooling rate, tamping rate, remelt temperature and rate on eutectic Al-Si yield.

  3. Orbit Transfer Systems with Emphasis on Shuttle Applications, 1986-1991

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A systems study is presented for a transportation system which will follow the interim upper stage and spinning solid upper stage. Included are concepts, concept comparisons, trends, parametric data, etc. associated with the future system. Relevant technical and programmatic information is developed. This information is intended to focus future activity to identify attractive options and to summarize the major issues associated with the future development of the system. To establish a common basis for identifying current transportation concepts, an orbit transfer vehicle (OTV) is defined as a propulsive (velocity producing) rocket or stage. When used with a crew transfer module, a manned sortie module or other payloads, the combination becomes an orbit transfer system (OTS). Standardization of OTV's and OTS's is required.

  4. Guidance: Interim Municipal Settlement Policy

    EPA Pesticide Factsheets

    Interim guidance and fact sheets regarding settlements involving municipalities or municipal waste under Section 122 CERCLA as amended by SARA. Interim policy sets forth the criteria by which EPA generally determines whether to exercise enforcement discretion to pursue MSW generators and transporters as PRPs.

  5. Technical progress in silicon sheet growth under DOE/JPL FSA program, 1975-1986

    NASA Technical Reports Server (NTRS)

    Kalejs, J. P.

    1986-01-01

    The technical progress made in the Silicon Sheet Growth Program during its 11 years was reviewed. At present, in 1986, only two of the original 9 techniques have survived to the start-up, pilot-plant stage in industry. These two techniques are the edge-defined, film-fed growth (EFG) technique that produces closed shape polygons, and the WEB dendritic technique that produces single ribbons. Both the status and future concerns of the EFG and WEB techniques were discussed.

  6. Annual Progress Report (17th) and 1992-97 Renewal Proposal Interactive Graphics for Molecular Studies

    DTIC Science & Technology

    1991-01-24

    Molecular Graphics, vol. 6, No. 4 (Dec. 1988), p. 223. Turk, Greg, "Interactive Collision Detection for Molecular Graphics," M.S. thesis , UNC-Chapel Hill...Problem," Master’s thesis , UNC Department of Computer Science Technical Report #TR87-013, May 1987. Pique, ME., "Technical Trends in Molecular Graphics...AD-A236 598 Seventeenth Annual Progress Report and 1992-97 Renewal Proposal Interactive Graphics for Molecular Studies TR91-020 January 24, 1991 red

  7. Enhanced oil recovery utilizing high-angle wells in the Frontier Formation, Badger Basin Field, Park County, Wyoming. Quarterly technical progress report, 1 March 1993--30 June 1993

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fortmann, R.G.; Walker, J.P.

    1993-07-10

    Sierra Energy Company`s targeted goals during the third quarter of this Cooperative Agreement included the following objectives from the Statement of Work: in Phase 2A, completion of subtask 2.1.2--acquire best possible field data in the 3-D seismic program; and initiation of Subtask 2.1.3--process acquired 3-D seismic data. Technical progress is described for these tasks.

  8. 10 CFR 603.1100 - Contracting officer's post-award responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... technical progress, financial status, and future program plans. (b) Tracking and processing of reports... progress reports, and patent reports. (c) Handling payment requests and related matters. For a TIA using advance payments, that includes reviews of progress to verify that there is continued justification for...

  9. 7 CFR 3402.23 - Documentation of progress on funded projects.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the academic program due to unsatisfactory academic progress; or voluntarily withdraws from the Fellowship or the academic program. If a Fellow has not completed all degree requirements at the end of the... database contains narrative project information, progress/impact statements, and final technical reports...

  10. 7 CFR 3402.23 - Documentation of progress on funded projects.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the academic program due to unsatisfactory academic progress; or voluntarily withdraws from the Fellowship or the academic program. If a Fellow has not completed all degree requirements at the end of the... database contains narrative project information, progress/impact statements, and final technical reports...

  11. 7 CFR 3402.23 - Documentation of progress on funded projects.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the academic program due to unsatisfactory academic progress; or voluntarily withdraws from the Fellowship or the academic program. If a Fellow has not completed all degree requirements at the end of the... database contains narrative project information, progress/impact statements, and final technical reports...

  12. 7 CFR 3402.23 - Documentation of progress on funded projects.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the academic program due to unsatisfactory academic progress; or voluntarily withdraws from the Fellowship or the academic program. If a Fellow has not completed all degree requirements at the end of the... database contains narrative project information, progress/impact statements, and final technical reports...

  13. Efficacy and safety of cisplatin, dexamethasone, gemcitabine and pegaspargase (DDGP) regimen in newly diagnosed, advanced-stage extranodal natural killer/T-cell lymphoma: interim analysis of a phase 4 study NCT01501149

    PubMed Central

    Li, Ling; Li, Xin; Wang, Xinhua; Fu, Xiaorui; Ma, Wang; Qin, Yanru; Li, Wencai; Wu, Jingjing; Sun, Zhenchang; Zhang, Xudong; Nan, Feifei; Chang, Yu; Li, Zhaoming; Zhang, Dandan; Wang, Guannan; Yan, Jiaqin; Su, Liping; Wang, Jinghua; Xue, Hongwei; Young, Ken H.; Zhang, Mingzhi

    2016-01-01

    To explore a more effective treatment for newly diagnosed, advanced-stage extranodal natural killer/T-cell lymphoma, nasal type (ENKTL), we conducted a phase 4 study of the cisplatin, dexamethasone, gemcitabine, pegaspargase (DDGP) regimen. The primary end point was the 2-year progression-free survival (PFS) after the protocol treatment. Secondary endpoints included response rate (RR), overall survival (OS) and median survival time (MST). The interim analysis included data only from March 2011 to September 2013, who received six cycles of DDGP chemotherapy. A total of 25 eligible patients were enrolled. Seventeen patients (17/24, 70.83%) achieved complete response (CR) and four (4/24, 16.67%) achieved partial response (PR), three (3/24, 12.50%) had progressive disease (PD). The RR after treatment was 87.50%. After a median follow-up duration of 24.67 months (range 4-48 months). The 2-year PFS and OS rate were 61.80% (95% CI, 42.00% to 81.60%) and 68.50 % (95% CI, 48.70% to 88.30%), respectively. The MST was 36.55 months (95% CI, 29.41 months to 43.70 months). Grade 3/4 leukopenia occurred in fourteen patients (58.33%) and grade 3/4 thrombocytopenia occurred in eleven patients (45.83%). Twelve patients (50.00%) experienced Activated Partial Phromboplastin Ptime (APTT) elongation and fourteen patients (58.33%) experienced hypofibrinogenemia. In conclusion, DDGP regimen is an effective and tolerated treatment for newly diagnosed, advanced-stage ENKTL. This trial was registered at www.ClinicalTrials.gov as #NCT01501149. PMID:27384676

  14. NAEP 1999 Long-Term Trend Technical Analysis Report: Three Decades of Student Performance. NCES 2005-484

    ERIC Educational Resources Information Center

    Allen, Nancy L.; McClellan, Catherine A.; Stoeckel, Joan J.

    2005-01-01

    This report provides an update to the technical analysis procedures documenting the 1996 National Assessment of Educational Progress (NAEP) as presented in "The NAEP 1996 Technical Report" (Allen, Carlson, and Zelenak, 1999). It describes how the 1999 long-term trend data were incorporated into the trend analyses. Since no national main…

  15. Accounting for interim safety monitoring of an adverse event upon termination of a clinical trial.

    PubMed

    Dallas, Michael J

    2008-01-01

    Upon termination of a clinical trial that uses interim evaluations to determine whether the trial can be stopped, a proper statistical analysis must account for the interim evaluations. For example, in a group-sequential design where the efficacy of a treatment regimen is evaluated at interim stages, and the opportunity to stop the trial based on positive efficacy findings exists, the terminal p-value, point estimate, and confidence limits of the outcome of interest must be adjusted to eliminate bias. While it is standard practice to adjust terminal statistical analyses due to opportunities to stop for "positive" findings, adjusting due to opportunities to stop for "negative" findings is also important. Stopping rules for negative findings are particularly useful when monitoring a specific rare serious adverse event in trials designed to show safety with respect to the event. In these settings, establishing conservative stopping rules are appropriate, and therefore accounting for the interim monitoring can have a substantial effect on the final results. Here I present a method to account for interim safety monitoring and illustrate its usefulness. The method is demonstrated to have advantages over methodology that does not account for interim monitoring.

  16. 28 CFR 94.41 - Interim emergency payment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

  17. 28 CFR 94.41 - Interim emergency payment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

  18. 28 CFR 94.41 - Interim emergency payment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

  19. 28 CFR 94.41 - Interim emergency payment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

  20. 28 CFR 94.41 - Interim emergency payment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Interim emergency payment. 94.41 Section 94.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Payment of Claims § 94.41 Interim emergency payment...

  1. 76 FR 4369 - Special Law Enforcement Commissions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Special Law Enforcement Commissions AGENCY... of the Interim Special Law Enforcement Commission Policy, Rules and Procedures, the Interim Special Law Enforcement Commission Protocols and the Interim Domestic Violence Waiver that will be used by the...

  2. 47 CFR 51.715 - Interim transport and termination pricing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Interim transport and termination pricing. 51... SERVICES (CONTINUED) INTERCONNECTION Reciprocal Compensation for Transport and Termination of Telecommunications Traffic § 51.715 Interim transport and termination pricing. (a) Upon request from a...

  3. 47 CFR 51.715 - Interim transport and termination pricing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Interim transport and termination pricing. 51... SERVICES (CONTINUED) INTERCONNECTION Reciprocal Compensation for Transport and Termination of Telecommunications Traffic § 51.715 Interim transport and termination pricing. (a) Upon request from a...

  4. A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials

    PubMed Central

    2009-01-01

    Background Decisions about interim analysis and early stopping of clinical trials, as based on recommendations of Data Monitoring Committees (DMCs), have far reaching consequences for the scientific validity and clinical impact of a trial. Our aim was to evaluate the frequency and quality of the reporting on DMC composition and roles, interim analysis and early termination in pediatric trials. Methods We conducted a systematic review of randomized controlled clinical trials published from 2005 to 2007 in a sample of four general and four pediatric journals. We used full-text databases to identify trials which reported on DMCs, interim analysis or early termination, and included children or adolescents. Information was extracted on general trial characteristics, risk of bias, and a set of parameters regarding DMC composition and roles, interim analysis and early termination. Results 110 of the 648 pediatric trials in this sample (17%) reported on DMC or interim analysis or early stopping, and were included; 68 from general and 42 from pediatric journals. The presence of DMCs was reported in 89 of the 110 included trials (81%); 62 papers, including 46 of the 89 that reported on DMCs (52%), also presented information about interim analysis. No paper adequately reported all DMC parameters, and nine (15%) reported all interim analysis details. Of 32 trials which terminated early, 22 (69%) did not report predefined stopping guidelines and 15 (47%) did not provide information on statistical monitoring methods. Conclusions Reporting on DMC composition and roles, on interim analysis results and on early termination of pediatric trials is incomplete and heterogeneous. We propose a minimal set of reporting parameters that will allow the reader to assess the validity of trial results. PMID:20003383

  5. 78 FR 55339 - Regulatory Capital Rules: Regulatory Capital, Implementation of Basel III, Capital Adequacy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ...The Federal Deposit Insurance Corporation (FDIC) is adopting an interim final rule that revises its risk-based and leverage capital requirements for FDIC-supervised institutions. This interim final rule is substantially identical to a joint final rule issued by the Office of the Comptroller of the Currency (OCC) and the Board of Governors of the Federal Reserve System (Federal Reserve) (together, with the FDIC, the agencies). The interim final rule consolidates three separate notices of proposed rulemaking that the agencies jointly published in the Federal Register on August 30, 2012, with selected changes. The interim final rule implements a revised definition of regulatory capital, a new common equity tier 1 minimum capital requirement, a higher minimum tier 1 capital requirement, and, for FDIC-supervised institutions subject to the advanced approaches risk-based capital rules, a supplementary leverage ratio that incorporates a broader set of exposures in the denominator. The interim final rule incorporates these new requirements into the FDIC's prompt corrective action (PCA) framework. In addition, the interim final rule establishes limits on FDIC-supervised institutions' capital distributions and certain discretionary bonus payments if the FDIC-supervised institution does not hold a specified amount of common equity tier 1 capital in addition to the amount necessary to meet its minimum risk-based capital requirements. The interim final rule amends the methodologies for determining risk-weighted assets for all FDIC-supervised institutions. The interim final rule also adopts changes to the FDIC's regulatory capital requirements that meet the requirements of section 171 and section 939A of the Dodd-Frank Wall Street Reform and Consumer Protection Act. The interim final rule also codifies the FDIC's regulatory capital rules, which have previously resided in various appendices to their respective regulations, into a harmonized integrated regulatory framework. In addition, the FDIC is amending the market risk capital rule (market risk rule) to apply to state savings associations. The FDIC is issuing these revisions to its capital regulations as an interim final rule. The FDIC invites comments on the interaction of this rule with other proposed leverage ratio requirements applicable to large, systemically important banking organizations. This interim final rule otherwise contains regulatory text that is identical to the common rule text adopted as a final rule by the Federal Reserve and the OCC. This interim final rule enables the FDIC to proceed on a unified, expedited basis with the other federal banking agencies pending consideration of other issues. Specifically, the FDIC intends to evaluate this interim final rule in the context of the proposed well- capitalized and buffer levels of the supplementary leverage ratio applicable to large, systemically important banking organizations, as described in a separate Notice of Proposed Rulemaking (NPR) published in the Federal Register August 20, 2013. The FDIC is seeking commenters' views on the interaction of this interim final rule with the proposed rule regarding the supplementary leverage ratio for large, systemically important banking organizations.

  6. Technologies for diagnosis and treatment of acute stroke

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fitch, J.P.

    1998-02-09

    From October 1994 to June 1997, a multidisciplinary team of scientists and engineers at Lawrence Livermore National Laboratory were funded through LDRD to develop and integrate technologies for diagnosis and treatment of acute stroke. The project was summarized in a Science and Technology Review article `Brain Attack` that appeared in June 1997 and again in the Center for Healthcare Technologies Report (UCRL-LR-124761). This article is the best overview of the project, epidemiology of stroke and technical progress. Most of the technical progress has been documented in conference papers and presentations and refereed journal articles. Additional technical publication can be expectedmore » as our remaining patent applications progress through the US Patent and Trademark Office. The purpose of this report is to provide an appropriate introduction and organization to the numerous publications so that interested readers can quickly find information. Because there is no documentation for the history of this project, this report provides a summary. It also provides the final status report for the LDRD funding.« less

  7. 42 CFR 417.574 - Interim settlement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Interim settlement. 417.574 Section 417.574 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... PLANS Medicare Payment: Cost Basis § 417.574 Interim settlement. (a) Determination. Within 30 days...

  8. 14 CFR 136.41 - Interim operating authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Interim operating authority. 136.41 Section 136.41 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... technology, as appropriate, and (9) Shall allow for modifications of the interim operating authority based on...

  9. 14 CFR 136.41 - Interim operating authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Interim operating authority. 136.41 Section 136.41 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... technology, as appropriate, and (9) Shall allow for modifications of the interim operating authority based on...

  10. 47 CFR 73.404 - Interim hybrid IBOC DAB operation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Interim hybrid IBOC DAB operation. 73.404 Section 73.404 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The...

  11. 47 CFR 73.404 - Interim hybrid IBOC DAB operation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Interim hybrid IBOC DAB operation. 73.404 Section 73.404 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The...

  12. 47 CFR 73.404 - Interim hybrid IBOC DAB operation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Interim hybrid IBOC DAB operation. 73.404 Section 73.404 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The...

  13. 47 CFR 73.404 - Interim hybrid IBOC DAB operation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Interim hybrid IBOC DAB operation. 73.404 Section 73.404 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The...

  14. 10 CFR 590.403 - Emergency interim orders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DEPARTMENT OF ENERGY (CONTINUED) NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION) ADMINISTRATIVE PROCEDURES WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS Opinions and Orders § 590.403 Emergency interim... and issue an emergency interim order authorizing the import or export of natural gas. After issuance...

  15. 49 CFR 37.193 - Interim service requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Interim service requirements. 37.193 Section 37.193 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.193 Interim service requirements. (a) Until...

  16. 76 FR 57657 - Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ...] Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation establishes an extension of time-limited interim..., and Cosmetic Act (FFDCA). The time-limited tolerances expire on March 18, 2013. DATES: This regulation...

  17. 45 CFR 1623.6 - Interim funding.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

  18. 45 CFR 1623.6 - Interim funding.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

  19. 45 CFR 1623.6 - Interim funding.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

  20. 45 CFR 1623.6 - Interim funding.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

  1. 45 CFR 1623.6 - Interim funding.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Interim funding. 1623.6 Section 1623.6 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION SUSPENSION PROCEDURES § 1623.6 Interim funding. (a) Pending the completion of suspension proceedings under this part...

  2. An interim prosthesis program for lower limb amputees: comparison of public and private models of service.

    PubMed

    Gordon, Robert; Magee, Christopher; Frazer, Anna; Evans, Craig; McCosker, Kathryn

    2010-06-01

    This study compared the outcomes of an interim mechanical prosthesis program for lower limb amputees operated under a public and private model of service. Over a two-year period, 60 transtibial amputees were fitted with an interim prosthesis as part of their early amputee care. Thirty-four patients received early amputee care under a public model of service, whereby a prosthetist was employed to provide the interim mechanical prosthesis service. The remaining 26 patients received early amputee care under a private model of service, where an external company was contracted to provide the interim mechanical prosthesis service. The results suggested comparable clinical outcomes between the two patient groups. However, the public model appeared to be less expensive with the average labour cost per patient being 29.0% lower compared with the private model. The results suggest that a public model of service may provide a more comprehensive and less expensive interim prosthesis program for lower limb amputees.

  3. Proceedings: Computer Science and Data Systems Technical Symposium, volume 2

    NASA Technical Reports Server (NTRS)

    Larsen, Ronald L.; Wallgren, Kenneth

    1985-01-01

    Progress reports and technical updates of programs being performed by NASA centers are covered. Presentations in viewgraph form, along with abstracts, are included for topics in three catagories: computer science, data systems, and space station applications.

  4. A study on operation efficiency evaluation based on firm's financial index and benchmark selection: take China Unicom as an example

    NASA Astrophysics Data System (ADS)

    Wu, Zu-guang; Tian, Zhan-jun; Liu, Hui; Huang, Rui; Zhu, Guo-hua

    2009-07-01

    Being the only listed telecom operators of A share market, China Unicom has always been attracted many institutional investors under the concept of 3G recent years,which itself is a great technical progress expectation.Do the institutional investors or the concept of technical progress have signficant effect on the improving of firm's operating efficiency?Though reviewing the documentary about operating efficiency we find that schoolars study this problem useing the regress analyzing based on traditional production function and data envelopment analysis(DEA) and financial index anayzing and marginal function and capital labor ratio coefficient etc. All the methods mainly based on macrodata. This paper we use the micro-data of company to evaluate the operating efficiency.Using factor analyzing based on financial index and comparing the factor score of three years from 2005 to 2007, we find that China Unicom's operating efficiency is under the averge level of benchmark corporates and has't improved under the concept of 3G from 2005 to 2007.In other words,institutional investor or the conception of technical progress expectation have faint effect on the changes of China Unicom's operating efficiency. Selecting benchmark corporates as post to evaluate the operating efficiency is a characteristic of this method ,which is basicallly sipmly and direct.This method is suit for the operation efficiency evaluation of agriculture listed companies because agriculture listed also face technical progress and marketing concept such as tax-free etc.

  5. Decontamination Systems Information and Research Program. Quarterly technical progress report, January 1--March 31, 1994

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1994-05-01

    West Virginia University (WVU) and the US DOE Morgantown Energy Technology Center (METC) entered into a Cooperative Agreement on August 29, 1992 entitled ``Decontamination Systems Information and Research Programs.`` Stipulated within the Agreement is the requirement that WVU submit to METC a series of Technical Progress Reports on a quarterly basis. This report comprises the first Quarterly Technical Progress Report for Year 2 of the Agreement. This report reflects the progress and/or efforts performed on the sixteen (16) technical projects encompassed by the Year 2 Agreement for the period of January 1 through March 31, 1994. In situ bioremediation ofmore » chlorinated organic solvents; Microbial enrichment for enhancing in-situ biodegradation of hazardous organic wastes; Treatment of volatile organic compounds (VOCs) using biofilters; Drain-enhanced soil flushing (DESF) for organic contaminants removal; Chemical destruction of chlorinated organic compounds; Remediation of hazardous sites with steam reforming; Soil decontamination with a packed flotation column; Use of granular activated carbon columns for the simultaneous removal of organics, heavy metals, and radionuclides; Monolayer and multilayer self-assembled polyion films for gas-phase chemical sensors; Compact mercuric iodide detector technology development; Evaluation of IR and mass spectrometric techniques for on-site monitoring of volatile organic compounds; A systematic database of the state of hazardous waste clean-up technologies; Dust control methods for insitu nuclear and hazardous waste handling; Winfield Lock and Dam remediation; and Socio-economic assessment of alternative environmental restoration technologies.« less

  6. 78 FR 14487 - Tetrachlorvinphos; Proposed Extension of Time-Limited Interim Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ...] Tetrachlorvinphos; Proposed Extension of Time-Limited Interim Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. SUMMARY: This regulation proposes the extension of the time-limited... related to EPA's extension of the time-limited interim tolerances for the combined residues of the...

  7. 78 FR 15880 - Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation extends the time-limited interim tolerances for the... . II. Background A detailed summary of the background related to EPA's extension of the time-limited...

  8. 24 CFR 115.207 - Consequences of interim certification and certification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Consequences of interim certification and certification. 115.207 Section 115.207 Housing and Urban Development Regulations Relating to... ENFORCEMENT AGENCIES Certification of Substantially Equivalent Agencies § 115.207 Consequences of interim...

  9. 46 CFR 308.203 - Amount insured under interim binder.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

  10. 46 CFR 308.203 - Amount insured under interim binder.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

  11. 46 CFR 308.203 - Amount insured under interim binder.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

  12. 46 CFR 308.203 - Amount insured under interim binder.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

  13. 46 CFR 308.203 - Amount insured under interim binder.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

  14. 76 FR 74834 - Interim Staff Guidance on Aging Management Program for Steam Generators

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... NRC staff's evaluation of the suitability of using Revision 3 of the Nuclear Energy Institute's (NEI... NUCLEAR REGULATORY COMMISSION [NRC-2011-0228] Interim Staff Guidance on Aging Management Program for Steam Generators AGENCY: Nuclear Regulatory Commission. ACTION: Interim staff guidance; issuance...

  15. Seizing the Future: How Ohio's Career-Technical Education Programs Fuse Academic Rigor and Real-World Experiences to Prepare Students for College and Careers

    ERIC Educational Resources Information Center

    Guarino, Heidi; Yoder, Shaun

    2015-01-01

    "Seizing the Future: How Ohio's Career and Technical Education Programs Fuse Academic Rigor and Real-World Experiences to Prepare Students for College and Work," demonstrates Ohio's progress in developing strong policies for career and technical education (CTE) programs to promote rigor, including college- and career-ready graduation…

  16. Case Study on Technical and Vocational Education in Japan. Case Studies on Technical and Vocational Education in Asia and the Pacific.

    ERIC Educational Resources Information Center

    Iwamoto, Muneharu

    In the course of Japan's economic progress, remarkable changes have occurred in the structure of industry and employment. Workers are in extremely short supply in such occupations as mining, manufacturing and construction, services, transportation and communication, sales, and professional and technical. On the basis of recommendations of the…

  17. 25 CFR 30.104 - What is the Secretary's definition of AYP?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... PROGRESS Defining Adequate Yearly Progress § 30.104 What is the Secretary's definition of AYP? The... accepted by the Department of Education. The Secretary is committed to providing technical assistance to a...

  18. 25 CFR 30.104 - What is the Secretary's definition of AYP?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PROGRESS Defining Adequate Yearly Progress § 30.104 What is the Secretary's definition of AYP? The... accepted by the Department of Education. The Secretary is committed to providing technical assistance to a...

  19. 30 CFR 827.13 - Coal preparation plants: Interim performance standards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

  20. 30 CFR 827.13 - Coal preparation plants: Interim performance standards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

  1. 30 CFR 827.13 - Coal preparation plants: Interim performance standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

  2. 30 CFR 827.13 - Coal preparation plants: Interim performance standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

  3. 30 CFR 827.13 - Coal preparation plants: Interim performance standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Coal preparation plants: Interim performance...-COAL PREPARATION PLANTS NOT LOCATED WITHIN THE PERMIT AREA OF A MINE § 827.13 Coal preparation plants: Interim performance standards. (a) Persons operating or who have operated coal preparation plants after...

  4. 75 FR 13484 - Foreign-Trade Zone 22; Temporary/Interim Manufacturing Authority; LG Electronics Mobilecomm USA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... DEPARTMENT OF COMMERCE [Docket T-1-2010] Foreign-Trade Zones Board Foreign-Trade Zone 22; Temporary/Interim Manufacturing Authority; LG Electronics Mobilecomm USA, Inc. (Cell Phones); Notice of.../ interim manufacturing (T/IM) authority, on behalf of LG Electronics Mobilecomm USA, Inc. (LGEMU), to...

  5. 76 FR 37781 - Foreign-Trade Zone 26; Atlanta, GA; Application for Temporary/Interim Manufacturing Authority...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ..., GA; Application for Temporary/ Interim Manufacturing Authority; Makita Corporation of America; (Hand- Held Power Tool and Gasoline/Electric-Powered Garden Product Manufacturing); Buford, GA An application... Georgia Foreign-Trade Zone, Inc., grantee of FTZ 26, requesting temporary/interim manufacturing (T/IM...

  6. Interim Action Proposed Plan for the Chemicals, Metals, and Pesticides (CMP) Pits Operable Unit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bradley, J.

    2002-06-18

    The purpose of this Interim Action Proposed Plan (IAPP) is to describe the preferred interim remedial action for addressing the Chemicals, Metals, and Pesticides (CMP) Pits Operable Unit and to provide an opportunity for public input into the remedial action selection process.

  7. The Intentional Interim

    ERIC Educational Resources Information Center

    Nugent, Patricia A.

    2011-01-01

    The author spent years in central-office administration, most recently in an interim position. Some interim administrators simply see themselves as placeholders until the real deal is hired, giving the organization the opportunity to coast. There are others who see themselves as change agents and cannot wait to undo or redo what their predecessor…

  8. Presidential Transition: The Experience of Two Community College Interim Presidents

    ERIC Educational Resources Information Center

    Thompson, Matthew D.

    2010-01-01

    The purpose of this qualitative case study was to understand the experiences of two community college interim presidents, their characteristics, and how they led institutions following an abrupt presidential departure. There were two fundamental questions framing this research study, 1. How do two interim community college presidents lead…

  9. 47 CFR 73.404 - Interim hybrid IBOC DAB operation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... RADIO BROADCAST SERVICES Digital Audio Broadcasting § 73.404 Interim hybrid IBOC DAB operation. (a) The... test operation pursuant to § 73.1620, may commence interim hybrid IBOC DAB operation with digital... No. 99-325. FM stations are permitted to operate with hybrid digital effective radiated power equal...

  10. 17 CFR 210.10-01 - Interim financial statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... accountant on the review must be filed with the interim financial statements. (e) Filing of other interim... sheets shall include only major captions (i.e., numbered captions) prescribed by the applicable sections... the date of any material accounting change and the reasons for making it. In addition, for filings on...

  11. 77 FR 55232 - Japan Lessons-Learned Project Directorate Interim Staff Guidance JLD-ISG-2012-03; Compliance With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... NUCLEAR REGULATORY COMMISSION [NRC-2012-0067] Japan Lessons-Learned Project Directorate Interim...-Learned Project Directorate Interim Staff Guidance; issuance. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC or the Commission) is issuing the Final Japan Lessons-Learned Project Directorate (JLD...

  12. 78 FR 40199 - Draft Spent Fuel Storage and Transportation Interim Staff Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0140] Draft Spent Fuel Storage and Transportation Interim... Spent Fuel Storage and Transportation Interim Staff Guidance No. 24 (SFST-ISG-24), Revision 0, ``The Use of a Demonstration Program as Confirmation of Integrity for Continued Storage of High Burnup Fuel...

  13. 75 FR 66553 - Truth in Lending

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... AGENCY: Board of Governors of the Federal Reserve System. ACTION: Interim final rule; request for public comment. SUMMARY: The Board is publishing for public comment an interim final rule amending Regulation Z (Truth in Lending). The interim rule implements Section 129E of the Truth in Lending Act (TILA), which...

  14. Staff Reactions to Interim Leadership in a Student Affairs Organization

    ERIC Educational Resources Information Center

    Jones, Robin D.

    2011-01-01

    Interim leadership appointments in higher education are a common strategy used to fill leadership gaps in executive positions. Because student affairs executives are particularly vulnerable to high turnover rates, interim appointments are becoming more widespread. Even with the prevalence of this trend, little attention has been given to the…

  15. Faculty and Student Views of the Interim Term

    ERIC Educational Resources Information Center

    Centra, John A.; Sobol, Marion G.

    1974-01-01

    Evaluations of the interim term or 4-1-4 program at various colleges have been generally favorable. A detailed evaluation of the Rider College interim study program based on faculty and student reports indicated that the more nontraditionally oriented courses were rated higher than the more traditional offerings. (Editor/PG)

  16. 12 CFR 541.18 - Interim Federal savings association.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... an existing savings and loan holding company or to facilitate any other transaction the Office may... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Interim Federal savings association. 541.18... REGULATIONS AFFECTING FEDERAL SAVINGS ASSOCIATIONS § 541.18 Interim Federal savings association. The term...

  17. 15 CFR 904.322 - Interim action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Interim action. 904.322 Section 904... Sanctions and Denials Permit Sanction for Violations § 904.322 Interim action. (a) To protect marine resources during the pendency of an action under this subpart, in cases of willfulness, or as otherwise...

  18. 15 CFR 904.322 - Interim action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Interim action. 904.322 Section 904... Sanctions and Denials Permit Sanction for Violations § 904.322 Interim action. (a) To protect marine resources during the pendency of an action under this subpart, in cases of willfulness, or as otherwise...

  19. Into the Sunset: Reflections of an Interim Administrator.

    ERIC Educational Resources Information Center

    Marlowe, John

    2000-01-01

    One advantage to an interim administrative position is that the public cuts short-timers a little slack. Temporary administrators can learn on the job and become experts on specialized subjects. Personnel issues demand more time than interims possess. Such positions usually do not turn into long-term contracts. (MLH)

  20. PCoD Lite - Using an Interim PCoD Protocol to Assess the Effects of Disturbance Associated with US Navy Exercises on Marine Mammal Populations

    DTIC Science & Technology

    2015-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. PCoD Lite - Using an Interim PCoD Protocol to Assess...US National Research Council (NRC 2005). Here, we provide an insight into how the Interim PCoD approach (Harwood et al. 2014, King et al. 2015...illustrate how the interim PCoD protocol can be used to inform the process of determining whether or not Navy activities are likely to have an impact on

  1. KDHE Project Code: C6-074-00002: Progress and Monitoring Report for the LDB/SVE/AS System at the Former CCC/USDA Grain Storage Facility, Agra, Kansas, in January-June 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    LaFreniere, Lorraine M.

    In 2008-2009, to address the carbon tetrachloride contamination detected on its former property, the CCC/USDA implemented a source area cleanup in accord with the document Interim Measure Work Plan/Design for Agra, Kansas (IMWP/D; Argonne 2008). The cleanup involves five large-diameter boreholes (LDBs) coupled with soil vapor extraction (SVE) and air sparge (AS) systems. The work plan was approved by the Kansas Department of Health and Environment (KDHE) in November 2008 (KDHE 2008b), and operation began in May 2009.

  2. KDHE Project Code: C6-074-00002: Progress and Monitoring Report for the LDB/SVE/AS System at the Former CCC/USDA Grain Storage Facility, Agra, Kansas, in January-June 2013

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    LaFreniere, Lorraine

    In 2008-2009, to address the carbon tetrachloride contamination detected on its former property, the CCC/USDA implemented a source area cleanup in accord with the document Interim Measure Work Plan/Design for Agra, Kansas (IMWP/D; Argonne 2008). The cleanup involves five large-diameter boreholes (LDBs) coupled with soil vapor extraction (SVE) and air sparging (AS). The work plan was approved by the Kansas Department of Health and Environment (KDHE) in November 2008 (KDHE 2008b), and operation began in May 2009.

  3. KDHE POroject Code: C6-074-00002: Progress and Monitoring Report for the LBD/SVE/AS System at the Former CCC/USDA Grain Storage Facility, Agra, Kansas, in January-June 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    LaFreniere, Lorraine M.

    In 2008-2009, to address the carbon tetrachloride contamination detected on its former property, the CCC/USDA implemented a source area cleanup in accord with the document Interim Measure Work Plan/Design for Agra, Kansas (IMWP/D; Argonne 2008). The cleanup involves five large-diameter boreholes (LDBs) coupled with soil vapor extraction (SVE) and air sparge (AS) systems. The work plan was approved by the Kansas Department of Health and Environment (KDHE) in November 2008 (KDHE 2008b), and operation began in May 2009.

  4. ANNUAL REPORT, JULY 1, 1958

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1959-02-01

    This annual report of Brookhaven National Laboratory describes its program and activities for the fiscal year 1958. The progress and trends of the research program are presented along with a description of the operational, service, and administrative activities of the Laboratory. The scientific and technical details of the many research and development activities are covered more fully in scientific and technical periodicals and in the quarterly scientific progress reports and other scientiflc reports of the Laboratory. A list of all publications for July 1, 1957 to June 30, 1958, is given. Status and progress are given in fields of physics,more » accelerator development, instrumentation, applied mathematics, chemistry, nuclear engineering, biology, and medical research. (For preceding period see BNL-462.) (W.D.M.)« less

  5. Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy.

    PubMed

    Eichler, Florian; Duncan, Christine; Musolino, Patricia L; Orchard, Paul J; De Oliveira, Satiro; Thrasher, Adrian J; Armant, Myriam; Dansereau, Colleen; Lund, Troy C; Miller, Weston P; Raymond, Gerald V; Sankar, Raman; Shah, Ami J; Sevin, Caroline; Gaspar, H Bobby; Gissen, Paul; Amartino, Hernan; Bratkovic, Drago; Smith, Nicholas J C; Paker, Asif M; Shamir, Esther; O'Meara, Tara; Davidson, David; Aubourg, Patrick; Williams, David A

    2017-10-26

    In X-linked adrenoleukodystrophy, mutations in ABCD1 lead to loss of function of the ALD protein. Cerebral adrenoleukodystrophy is characterized by demyelination and neurodegeneration. Disease progression, which leads to loss of neurologic function and death, can be halted only with allogeneic hematopoietic stem-cell transplantation. We enrolled boys with cerebral adrenoleukodystrophy in a single-group, open-label, phase 2-3 safety and efficacy study. Patients were required to have early-stage disease and gadolinium enhancement on magnetic resonance imaging (MRI) at screening. The investigational therapy involved infusion of autologous CD34+ cells transduced with the elivaldogene tavalentivec (Lenti-D) lentiviral vector. In this interim analysis, patients were assessed for the occurrence of graft-versus-host disease, death, and major functional disabilities, as well as changes in neurologic function and in the extent of lesions on MRI. The primary end point was being alive and having no major functional disability at 24 months after infusion. A total of 17 boys received Lenti-D gene therapy. At the time of the interim analysis, the median follow-up was 29.4 months (range, 21.6 to 42.0). All the patients had gene-marked cells after engraftment, with no evidence of preferential integration near known oncogenes or clonal outgrowth. Measurable ALD protein was observed in all the patients. No treatment-related death or graft-versus-host disease had been reported; 15 of the 17 patients (88%) were alive and free of major functional disability, with minimal clinical symptoms. One patient, who had had rapid neurologic deterioration, had died from disease progression. Another patient, who had had evidence of disease progression on MRI, had withdrawn from the study to undergo allogeneic stem-cell transplantation and later died from transplantation-related complications. Early results of this study suggest that Lenti-D gene therapy may be a safe and effective alternative to allogeneic stem-cell transplantation in boys with early-stage cerebral adrenoleukodystrophy. Additional follow-up is needed to fully assess the duration of response and long-term safety. (Funded by Bluebird Bio and others; STARBEAM ClinicalTrials.gov number, NCT01896102 ; ClinicalTrialsRegister.eu number, 2011-001953-10 .).

  6. Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.

    PubMed

    Soria, Jean-Charles; Ohe, Yuichiro; Vansteenkiste, Johan; Reungwetwattana, Thanyanan; Chewaskulyong, Busyamas; Lee, Ki Hyeong; Dechaphunkul, Arunee; Imamura, Fumio; Nogami, Naoyuki; Kurata, Takayasu; Okamoto, Isamu; Zhou, Caicun; Cho, Byoung Chul; Cheng, Ying; Cho, Eun Kyung; Voon, Pei Jye; Planchard, David; Su, Wu-Chou; Gray, Jhanelle E; Lee, Siow-Ming; Hodge, Rachel; Marotti, Marcelo; Rukazenkov, Yuri; Ramalingam, Suresh S

    2018-01-11

    Osimertinib is an oral, third-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that selectively inhibits both EGFR-TKI-sensitizing and EGFR T790M resistance mutations. We compared osimertinib with standard EGFR-TKIs in patients with previously untreated, EGFR mutation-positive advanced non-small-cell lung cancer (NSCLC). In this double-blind, phase 3 trial, we randomly assigned 556 patients with previously untreated, EGFR mutation-positive (exon 19 deletion or L858R) advanced NSCLC in a 1:1 ratio to receive either osimertinib (at a dose of 80 mg once daily) or a standard EGFR-TKI (gefitinib at a dose of 250 mg once daily or erlotinib at a dose of 150 mg once daily). The primary end point was investigator-assessed progression-free survival. The median progression-free survival was significantly longer with osimertinib than with standard EGFR-TKIs (18.9 months vs. 10.2 months; hazard ratio for disease progression or death, 0.46; 95% confidence interval [CI], 0.37 to 0.57; P<0.001). The objective response rate was similar in the two groups: 80% with osimertinib and 76% with standard EGFR-TKIs (odds ratio, 1.27; 95% CI, 0.85 to 1.90; P=0.24). The median duration of response was 17.2 months (95% CI, 13.8 to 22.0) with osimertinib versus 8.5 months (95% CI, 7.3 to 9.8) with standard EGFR-TKIs. Data on overall survival were immature at the interim analysis (25% maturity). The survival rate at 18 months was 83% (95% CI, 78 to 87) with osimertinib and 71% (95% CI, 65 to 76) with standard EGFR-TKIs (hazard ratio for death, 0.63; 95% CI, 0.45 to 0.88; P=0.007 [nonsignificant in the interim analysis]). Adverse events of grade 3 or higher were less frequent with osimertinib than with standard EGFR-TKIs (34% vs. 45%). Osimertinib showed efficacy superior to that of standard EGFR-TKIs in the first-line treatment of EGFR mutation-positive advanced NSCLC, with a similar safety profile and lower rates of serious adverse events. (Funded by AstraZeneca; FLAURA ClinicalTrials.gov number, NCT02296125 .).

  7. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer.

    PubMed

    Swain, Sandra M; Baselga, José; Kim, Sung-Bae; Ro, Jungsil; Semiglazov, Vladimir; Campone, Mario; Ciruelos, Eva; Ferrero, Jean-Marc; Schneeweiss, Andreas; Heeson, Sarah; Clark, Emma; Ross, Graham; Benyunes, Mark C; Cortés, Javier

    2015-02-19

    In patients with metastatic breast cancer that is positive for human epidermal growth factor receptor 2 (HER2), progression-free survival was significantly improved after first-line therapy with pertuzumab, trastuzumab, and docetaxel, as compared with placebo, trastuzumab, and docetaxel. Overall survival was significantly improved with pertuzumab in an interim analysis without the median being reached. We report final prespecified overall survival results with a median follow-up of 50 months. We randomly assigned patients with metastatic breast cancer who had not received previous chemotherapy or anti-HER2 therapy for their metastatic disease to receive the pertuzumab combination or the placebo combination. The secondary end points of overall survival, investigator-assessed progression-free survival, independently assessed duration of response, and safety are reported. Sensitivity analyses were adjusted for patients who crossed over from placebo to pertuzumab after the interim analysis. The median overall survival was 56.5 months (95% confidence interval [CI], 49.3 to not reached) in the group receiving the pertuzumab combination, as compared with 40.8 months (95% CI, 35.8 to 48.3) in the group receiving the placebo combination (hazard ratio favoring the pertuzumab group, 0.68; 95% CI, 0.56 to 0.84; P<0.001), a difference of 15.7 months. This analysis was not adjusted for crossover to the pertuzumab group and is therefore conservative. Results of sensitivity analyses after adjustment for crossover were consistent. Median progression-free survival as assessed by investigators improved by 6.3 months in the pertuzumab group (hazard ratio, 0.68; 95% CI, 0.58 to 0.80). Pertuzumab extended the median duration of response by 7.7 months, as independently assessed. Most adverse events occurred during the administration of docetaxel in the two groups, with long-term cardiac safety maintained. In patients with HER2-positive metastatic breast cancer, the addition of pertuzumab to trastuzumab and docetaxel, as compared with the addition of placebo, significantly improved the median overall survival to 56.5 months and extended the results of previous analyses showing the efficacy of this drug combination. (Funded by F. Hoffmann-La Roche and Genentech; CLEOPATRA ClinicalTrials.gov number, NCT00567190.).

  8. Towards a space-borne quantum gravity gradiometer: progress in laboratory demonstration

    NASA Technical Reports Server (NTRS)

    Yu, Nan; Kohel, James M.; Kellogg, James R.; Maleki, Lute

    2005-01-01

    This paper describes the working principles and technical benefits of atom-wave interferometer-based inertial sensors, and gives a progress report on the development of a quantum gravity gradiometer for space applications at JPL.

  9. Technical Progress of the New Worlds Observer Mission

    NASA Astrophysics Data System (ADS)

    Lo, Amy; Noecker, C.; Cash, W.; NWO Study Team

    2009-01-01

    We report on the technical progress of the New Worlds Observer (NWO) mission concept. NWO is a two spacecraft mission that is capable of detecting and characterizing extra-solar, terrestrial planets and planetary systems. NWO consists of an external starshade and an UV-optical space telescope, flying in tandem. The starshade is a petal-shaped, opaque screen that creates an extremely dark shadow large enough to shade the telescope aperture from the target star. The NWO team has been addressing the top technology challenges of the concept, and report here our progress. We will present the current mission configuration best suited to address Terrestrial Planet Finding requirements, and highlight the technological breakthroughs that we have achieved this year. In particular, we will report on progress made in precision deployables for the large starshade, and the trajectory & alignment control system for NWO. We will also briefly highlight advances in understanding the starshade optical performance.

  10. 75 FR 7591 - Guidance on Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at CERCLA and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-SFUND-2009-0907; FRL-9114-6] RIN 2050-ZA05 Guidance on Recommended Interim Preliminary Remediation Goals for Dioxin in Soil at CERCLA and RCRA Sites; Extension of... Interim Preliminary Remediation Goals for Dioxin in Soil at Comprehensive Environmental Response...

  11. Do Interim Assessments Reduce the Race and SES Achievement Gaps?

    ERIC Educational Resources Information Center

    Konstantopoulos, Spyros; Li, Wei; Miller, Shazia R.; van der Ploeg, Arie

    2017-01-01

    The authors examined differential effects of interim assessments on minority and low socioeconomic status students' achievement in Grades K-6. They conducted a large-scale cluster randomized experiment in 2009-2010 to evaluate the impact of Indiana's policy initiative introducing interim assessments statewide. The authors used 2-level models to…

  12. 31 CFR 50.7 - Special Rules for Interim Guidance Safe Harbors.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Special Rules for Interim Guidance Safe Harbors. 50.7 Section 50.7 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.7 Special Rules for Interim Guidance Safe Harbors...

  13. 31 CFR 50.7 - Special Rules for Interim Guidance Safe Harbors.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Special Rules for Interim Guidance Safe Harbors. 50.7 Section 50.7 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.7 Special Rules for Interim Guidance Safe Harbors...

  14. 31 CFR 50.7 - Special Rules for Interim Guidance Safe Harbors.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Special Rules for Interim Guidance Safe Harbors. 50.7 Section 50.7 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.7 Special Rules for Interim Guidance Safe Harbors...

  15. 31 CFR 50.7 - Special Rules for Interim Guidance Safe Harbors.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Special Rules for Interim Guidance Safe Harbors. 50.7 Section 50.7 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.7 Special Rules for Interim Guidance Safe Harbors...

  16. 75 FR 54526 - Defense Federal Acquisition Regulation Supplement; Payment of Costs Prior to Definitization...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... in 48 CFR Part 217 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations...). ACTION: Final rule. SUMMARY: DoD is adopting as final, without change, an interim rule amending the... interim rule. Therefore, DoD is finalizing the interim rule without change. This rule was not subject to...

  17. 76 FR 43260 - Foreign-Trade Zone 72-Indianapolis, IN; Application for Temporary/Interim Manufacturing Authority...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ...--Indianapolis, IN; Application for Temporary/Interim Manufacturing Authority; Brevini Wind USA, Inc. (Wind... temporary/interim manufacturing (T/IM) authority within FTZ 72 at the Brevini Wind USA, Inc. (Brevini... requested authority to produce wind turbine gear boxes (HTSUS 8483.40, duty rate: 2.5%). Foreign components...

  18. 75 FR 60436 - Interim Change to the Military Freight Traffic Unified Rules Publication (MFTURP) No. 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... DEPARTMENT OF DEFENSE Department of the Army Interim Change to the Military Freight Traffic Unified Rules Publication (MFTURP) No. 1 AGENCY: Department of the Army, DoD. SUMMARY: The Military Surface Deployment and Distribution Command (SDDC) is providing notice that it is releasing an interim...

  19. 75 FR 24667 - Interim Change to the Military Freight Traffic Unified Rules Publication (MFTURP) No. 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... DEPARTMENT OF DEFENSE Department of the Army Interim Change to the Military Freight Traffic Unified Rules Publication (MFTURP) No. 1 AGENCY: Department of the Army, DoD. SUMMARY: The Military Surface Deployment and Distribution Command (SDDC) is providing notice that it released an interim change...

  20. 75 FR 10476 - Interim Change to the Military Freight Traffic Unified Rules Publication (MFTURP) No. 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... DEPARTMENT OF DEFENSE Department of the Army Interim Change to the Military Freight Traffic Unified Rules Publication (MFTURP) No. 1 AGENCY: Department of the Army, DoD. SUMMARY: The Military Surface Deployment and Distribution Command (SDDC) is providing notice that it released an interim change...

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