17 CFR 240.17i-4 - Internal risk management control system requirements for supervised investment bank holding...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Internal risk management... Supervised Investment Bank Holding Company Rules § 240.17i-4 Internal risk management control system...) As part of its internal risk management control system, a supervised investment bank holding company...

17 CFR 240.17i-4 - Internal risk management control system requirements for supervised investment bank holding...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Internal risk management... Supervised Investment Bank Holding Company Rules § 240.17i-4 Internal risk management control system...) As part of its internal risk management control system, a supervised investment bank holding company...

An Analysis of an Automatic Coolant Bypass in the International Space Station Node 2 Internal Active Thermal Control System

NASA Technical Reports Server (NTRS)

Clanton, Stephen E.; Holt, James M.; Turner, Larry D. (Technical Monitor)

2001-01-01

A challenging part of International Space Station (ISS) thermal control design is the ability to incorporate design changes into an integrated system without negatively impacting performance. The challenge presents itself in that the typical ISS Internal Active Thermal Control System (IATCS) consists of an integrated hardware/software system that provides active coolant resources to a variety of users. Software algorithms control the IATCS to specific temperatures, flow rates, and pressure differentials in order to meet the user-defined requirements. What may seem to be small design changes imposed on the system may in fact result in system instability or the temporary inability to meet user requirements. The purpose of this paper is to provide a brief description of the solution process and analyses used to implement one such design change that required the incorporation of an automatic coolant bypass in the ISS Node 2 element.

75 FR 1003 - Submission for OMB Review; Comment Request;

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

... internal risk management controls to assist it in managing the risks associated with its business... money laundering and terrorist financing as part of its internal risk management control system. Finally, Rule 17i-4 requires that an SIBHC periodically review its internal risk management control system for...

78 FR 77557 - Releasing Information; General Provisions; Accounting and Reporting Requirements; Reports of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

..., including controls for maintaining the confidentiality of borrower information. The system of internal... develop and implement an effective system of internal controls over the central data repository to ensure..., and maintain an effective system of internal controls over the data included in the report of accounts...

Predictive Thermal Control Applied to HabEx

NASA Technical Reports Server (NTRS)

Brooks, Thomas E.

2017-01-01

Exoplanet science can be accomplished with a telescope that has an internal coronagraph or with an external starshade. An internal coronagraph architecture requires extreme wavefront stability (10 pm change/10 minutes for 10(exp -10) contrast), so every source of wavefront error (WFE) must be controlled. Analysis has been done to estimate the thermal stability required to meet the wavefront stability requirement. This paper illustrates the potential of a new thermal control method called predictive thermal control (PTC) to achieve the required thermal stability. A simple development test using PTC indicates that PTC may meet the thermal stability requirements. Further testing of the PTC method in flight-like environments will be conducted in the X-ray and Cryogenic Facility (XRCF) at Marshall Space Flight Center (MSFC).

Predictive thermal control applied to HabEx

NASA Astrophysics Data System (ADS)

Brooks, Thomas E.

2017-09-01

Exoplanet science can be accomplished with a telescope that has an internal coronagraph or with an external starshade. An internal coronagraph architecture requires extreme wavefront stability (10 pm change/10 minutes for 10-10 contrast), so every source of wavefront error (WFE) must be controlled. Analysis has been done to estimate the thermal stability required to meet the wavefront stability requirement. This paper illustrates the potential of a new thermal control method called predictive thermal control (PTC) to achieve the required thermal stability. A simple development test using PTC indicates that PTC may meet the thermal stability requirements. Further testing of the PTC method in flight-like environments will be conducted in the X-ray and Cryogenic Facility (XRCF) at Marshall Space Flight Center (MSFC).

13 CFR 120.460 - What are SBA's additional requirements for SBA Supervised Lenders?

Code of Federal Regulations, 2010 CFR

2010-01-01

... the SBA Supervised Lender regulations that follow. (b) Operations and internal controls. Each SBA... company and does not have its own board of directors) must adopt an internal control policy which provides... operations, programs, and resources. The internal control policy must, at a minimum: (1) Direct management to...

75 FR 1455 - Custody of Funds or Securities of Clients by Investment Advisers

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-11

... the internal controls relating to the custody of those assets from an independent public accountant... must obtain or receive an internal control report within six months of the effective date. Section III... securities (SIFMA(AMG) Letter), requiring an internal control report only instead of both the report and a...

78 FR 53181 - Self-Regulatory Organizations; New York Stock Exchange LLC; Order Approving Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-28

... process of upgrading their accounting systems and internal controls and hiring additional staff to meet... thereunder, that require registered companies to devise and maintain a system of internal accounting controls... company's risk management processes and system of internal control. A listed company may choose to...

75 FR 59331 - Public Company Accounting Oversight Board; Notice of Filing of Proposed Rules on Auditing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... risk is a function of the effectiveness of the design and operation of internal control. 8. Inherent... integrated audit of financial statements and internal control over financial reporting, the requirements in Auditing Standard No. 5, An Audit of Internal Control Over Financial Reporting That Is Integrated with An...

7 CFR 277.17 - Audit requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Purpose of audit. Audits will include, at a minimum, an examination of the systems of internal control...) Include comments on weaknesses in and noncompliance with the systems of internal control, separately... expenditure of Federal funds; (4) Internal procedures have been established to meet the objectives of...

40 CFR Table 2 to Subpart Jjjj of... - Requirements for Performance Tests

Code of Federal Regulations, 2012 CFR

2012-07-01

... requirements 1. Stationary SI internal combustion engine demonstrating compliance according to § 60.4244 a. limit the concentration of NOX in the stationary SI internal combustion engine exhaust i. Select the... the outlet of the control device. ii. Determine the O2 concentration of the stationary internal...

Self-regulating control of parasitic loads in a fuel cell power system

NASA Technical Reports Server (NTRS)

Vasquez, Arturo (Inventor)

2011-01-01

A fuel cell power system comprises an internal or self-regulating control of a system or device requiring a parasitic load. The internal or self-regulating control utilizes certain components and an interconnection scheme to produce a desirable, variable voltage potential (i.e., power) to a system or device requiring parasitic load in response to varying operating conditions or requirements of an external load that is connected to a primary fuel cell stack of the system. Other embodiments comprise a method of designing such a self-regulated control scheme and a method of operating such a fuel cell power system.

17 CFR 240.17i-4 - Internal risk management control system requirements for supervised investment bank holding...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Internal risk management control system requirements for supervised investment bank holding companies. 240.17i-4 Section 240.17i-4 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, SECURITIES EXCHANGE ACT OF 1934...

17 CFR 240.17i-4 - Internal risk management control system requirements for supervised investment bank holding...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Internal risk management control system requirements for supervised investment bank holding companies. 240.17i-4 Section 240.17i-4 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, SECURITIES EXCHANGE ACT OF 1934...

Financial reporting practices: a comprehensive evaluation.

PubMed

Godwin, Norman H; Mueller, Jennifer M

2005-01-01

A distinguishing characteristic of high performance organizations is a strong internal control structure-controls that ensure patient care, compliance with regulations, internal efficiencies, and financial reporting. It is controls on financial reporting that are receiving a great deal of attention under a new law, the Sarbanes-Oxley Act of 2002. Public companies are now required by law to document controls over financial reporting, in order to fully address exposures and the effectiveness of current controls. Though many healthcare organizations are not directly affected by the law, regulatory agencies could follow suit and require similar compliance. In fact, several states have introduced bills that require nonprofit organizations to adhere to portions of the act. This article provides a guide for organizations desiring to stay ahead of the curve.

Globalization, international law, and emerging infectious diseases.

PubMed Central

Fidler, D. P.

1996-01-01

The global nature of the threat posed by new and reemerging infectious diseases will require international cooperation in identifying, controlling, and preventing these diseases. Because of this need for international cooperation, international law will certainly play a role in the global strategy for the control of emerging diseases. Recognizing this fact, the World Health Organization has already proposed revising the International Health Regulations. This article examines some basic problems that the global campaign against emerging infectious diseases might face in applying international law to facilitate international cooperation. The international legal component of the global control strategy for these diseases needs careful attention because of problems inherent in international law, especially as it applies to emerging infections issues. PMID:8903206

77 FR 64150 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-18

...) requires an annual study and evaluation of internal accounting controls under the Securities Exchange Act... an annual report on the adequacy of their internal accounting controls from an independent accountant... service only their own companies' securities. [[Page 64151

75 FR 64773 - Study Required by Section 989G(b) of the Dodd-Frank Act Regarding Compliance With Section 404(b...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

..., which addresses management's responsibility for reporting on the effectiveness of internal control over...) Quantitative and qualitative information about the trends of internal and external costs of having an external... over time; (3) Characteristics of internal controls, management's evaluation process and corporate...

7 CFR 1773.32 - Report on compliance and on internal control over financial reporting.

Code of Federal Regulations, 2010 CFR

2010-01-01

... financial reporting. 1773.32 Section 1773.32 Agriculture Regulations of the Department of Agriculture... RUS Reporting Requirements § 1773.32 Report on compliance and on internal control over financial... control over financial reporting including whether or not the tests performed provided sufficient evidence...

76 FR 10047 - Changes to the Public Housing Assessment System (PHAS): Financial Condition Scoring Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-23

... the Compliance and Other Matters Noted in internal control deficiency an Audit of the Financial... program major federal requirements (regardless of cause). Internal Controls and Compliance: 1. Control... Housing Assessment System (PHAS): Financial Condition Scoring Notice AGENCY: Office of the Assistant...

78 FR 31822 - Unincorporated Business Entities

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-28

... improper ``commingling,'' even though their internal controls maintain appropriate levels of separation... internal controls ensuring that UBE activity remains in compliance with the requirements of this rule... framework for Farm Credit System (System) institutions' use of unincorporated business entities (UBEs...

25 CFR 23.46 - Financial management, internal and external controls and other assurances.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Financial management, internal and external controls and other assurances. 23.46 Section 23.46 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES INDIAN CHILD WELFARE ACT General and Uniform Grant Administration Provisions and Requirements § 23.46 Financial management, internal an...

25 CFR 23.46 - Financial management, internal and external controls and other assurances.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Financial management, internal and external controls and other assurances. 23.46 Section 23.46 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES INDIAN CHILD WELFARE ACT General and Uniform Grant Administration Provisions and Requirements § 23.46 Financial management, internal an...

25 CFR 23.46 - Financial management, internal and external controls and other assurances.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Financial management, internal and external controls and other assurances. 23.46 Section 23.46 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES INDIAN CHILD WELFARE ACT General and Uniform Grant Administration Provisions and Requirements § 23.46 Financial management, internal and...

MODIS. Volume 1: MODIS level 1A software baseline requirements

NASA Technical Reports Server (NTRS)

Masuoka, Edward; Fleig, Albert; Ardanuy, Philip; Goff, Thomas; Carpenter, Lloyd; Solomon, Carl; Storey, James

1994-01-01

This document describes the level 1A software requirements for the moderate resolution imaging spectroradiometer (MODIS) instrument. This includes internal and external requirements. Internal requirements include functional, operational, and data processing as well as performance, quality, safety, and security engineering requirements. External requirements include those imposed by data archive and distribution systems (DADS); scheduling, control, monitoring, and accounting (SCMA); product management (PM) system; MODIS log; and product generation system (PGS). Implementation constraints and requirements for adapting the software to the physical environment are also included.

25 CFR 543.16 - What are the minimum internal controls for information technology?

Code of Federal Regulations, 2012 CFR

2012-04-01

... controls for information technology? (a) Physical security measures restricting access to agents, including... longer required. (2) In the event of remote access, the information technology employees must prepare a... 25 Indians 2 2012-04-01 2012-04-01 false What are the minimum internal controls for information...

25 CFR 543.16 - What are the minimum internal controls for information technology?

Code of Federal Regulations, 2011 CFR

2011-04-01

... controls for information technology? (a) Physical security measures restricting access to agents, including... longer required. (2) In the event of remote access, the information technology employees must prepare a... 25 Indians 2 2011-04-01 2011-04-01 false What are the minimum internal controls for information...

Service to the Nation, Strength for the Future. Fiscal Year 2013 United States Army Annual Financial Report

DTIC Science & Technology

2013-01-01

implementing several internal monthly controls testing initiatives, and other similar accomplishments geared to achieving a full audit-ready financial report...existence and completeness of assets, internal controls, and other critical functions required to meet audit readiness goals. The Army is on-track...ensure the integrity of their reporting systems, programs, and operations. This section focuses on the Army’s system of internal controls to

40 CFR 264.1084 - Standards: Tanks.

Code of Federal Regulations, 2010 CFR

2010-07-01

... internal floating roof in accordance with the requirements specified in paragraph (e) of this section; (2) A tank equipped with an external floating roof in accordance with the requirements specified in... operator who controls air pollutant emissions from a tank using a fixed roof with an internal floating roof...

22 CFR 126.10 - Disclosure of information.

Code of Federal Regulations, 2011 CFR

2011-04-01

....10 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES... Trade Controls. (b) Determinations required by law. Section 38(e) of the Arms Export Control Act (22 U.S... of certain persons, in accordance with Section 38 of the Arms Export Control Act. The requirements...

12 CFR 240.13 - Trading and operational standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... operational standards. (a) Internal rules, procedures, and controls required. A banking institution engaging in retail forex transactions shall establish and implement internal rules, procedures, and controls designed, at a minimum, to: (1) Ensure, to the extent reasonable, that each order received from a retail...

Planar solid oxide fuel cell with staged indirect-internal air and fuel preheating and reformation

DOEpatents

Geisbrecht, Rodney A; Williams, Mark C

2003-10-21

A solid oxide fuel cell arrangement and method of use that provides internal preheating of both fuel and air in order to maintain the optimum operating temperature for the production of energy. The internal preheat passes are created by the addition of two plates, one on either side of the bipolar plate, such that these plates create additional passes through the fuel cell. This internal preheat fuel cell configuration and method reduce the requirements for external heat exchanger units and air compressors. Air or fuel may be added to the fuel cell as required to maintain the optimum operating temperature through a cathode control valve or an anode control valve, respectively. A control loop comprises a temperature sensing means within the preheat air and fuel passes, a means to compare the measured temperature to a set point temperature and a determination based on the comparison as to whether the control valves should allow additional air or fuel into the preheat or bypass manifolds of the fuel cell.

75 FR 9327 - Aircraft Noise Certification Documents for International Operations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... in 14 CFR part 91 Aircraft, Noise control, Reporting and recordkeeping requirements. The Amendment 0...; Amendment No. 91-312] RIN 2120-AJ31 Aircraft Noise Certification Documents for International Operations... operating rules to require U.S. operators flying outside the United States to carry aircraft noise...

77 FR 75679 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

... et seq.). Rule 17Ad-13 requires an annual study and evaluation of internal accounting controls under... transfer agents to obtain an annual report on the adequacy of their internal accounting controls from an... service only their own companies' securities. Approximately 150 independent, professional transfer agents...

13 CFR 107.506 - Safeguarding Licensee's assets/Internal controls.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Safeguarding Licensee's assets/Internal controls. 107.506 Section 107.506 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Managing the Operations of a Licensee General Requirements § 107.506...

13 CFR 107.506 - Safeguarding Licensee's assets/Internal controls.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Safeguarding Licensee's assets/Internal controls. 107.506 Section 107.506 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Managing the Operations of a Licensee General Requirements § 107.506...

13 CFR 107.506 - Safeguarding Licensee's assets/Internal controls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Safeguarding Licensee's assets/Internal controls. 107.506 Section 107.506 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Managing the Operations of a Licensee General Requirements § 107.506...

13 CFR 107.506 - Safeguarding Licensee's assets/Internal controls.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Safeguarding Licensee's assets/Internal controls. 107.506 Section 107.506 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Managing the Operations of a Licensee General Requirements § 107.506...

13 CFR 107.506 - Safeguarding Licensee's assets/Internal controls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Safeguarding Licensee's assets/Internal controls. 107.506 Section 107.506 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Managing the Operations of a Licensee General Requirements § 107.506...

Emission Trade to Meet Reasonably Available Control Technology (RACT) for the State of New York

EPA Pesticide Factsheets

This revision establishes and requires an emission trade between Niagara Mohawk Power Corporation and Champion International Paper Corporation which will result in both sources meeting the requirements of Reasonably Available Control Technology for oxides

40 CFR 265.1085 - Standards: Tanks.

Code of Federal Regulations, 2010 CFR

2010-07-01

... controls shall use one of the following tanks: (1) A fixed-roof tank equipped with an internal floating... equipped with an external floating roof in accordance with the requirements specified in paragraph (f) of... controls air pollutant emissions from a tank using a fixed-roof with an internal floating roof shall meet...

12 CFR 609.940 - Internal systems and controls.

Code of Federal Regulations, 2012 CFR

2012-01-01

... business plan objectives and policies and procedures requirements regarding E-commerce; and (b) Prevent and... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Internal systems and controls. 609.940 Section 609.940 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ELECTRONIC COMMERCE Standards...

12 CFR 609.940 - Internal systems and controls.

Code of Federal Regulations, 2013 CFR

2013-01-01

... business plan objectives and policies and procedures requirements regarding E-commerce; and (b) Prevent and... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Internal systems and controls. 609.940 Section 609.940 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ELECTRONIC COMMERCE Standards...

12 CFR 609.940 - Internal systems and controls.

Code of Federal Regulations, 2011 CFR

2011-01-01

... business plan objectives and policies and procedures requirements regarding E-commerce; and (b) Prevent and... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Internal systems and controls. 609.940 Section 609.940 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ELECTRONIC COMMERCE Standards...

12 CFR 609.940 - Internal systems and controls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... business plan objectives and policies and procedures requirements regarding E-commerce; and (b) Prevent and... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Internal systems and controls. 609.940 Section 609.940 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ELECTRONIC COMMERCE Standards...

12 CFR 609.940 - Internal systems and controls.

Code of Federal Regulations, 2014 CFR

2014-01-01

... business plan objectives and policies and procedures requirements regarding E-commerce; and (b) Prevent and... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Internal systems and controls. 609.940 Section 609.940 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ELECTRONIC COMMERCE Standards...

40 CFR Table 2 to Subpart Jjjj of... - Requirements for Performance Tests

Code of Federal Regulations, 2013 CFR

2013-07-01

... following requirements 1. Stationary SI internal combustion engine demonstrating compliance according to § 60.4244. a. limit the concentration of NOX in the stationary SI internal combustion engine exhaust i... must be located at the outlet of the control device. ii. Determine the O2 concentration of the...

46 CFR 27.205 - What are the requirements for internal communication systems on towing vessels?

Code of Federal Regulations, 2010 CFR

2010-10-01

... systems on towing vessels? 27.205 Section 27.205 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... fitted with a communication system between the engine room and the operating station that— (1) Consists... required to have internal communication systems. (c) When the operating-station's engine controls and the...

International Drug Control Policy

DTIC Science & Technology

2009-02-09

control agreements.1 Narcotic drugs include cannabis, cannabis resin, coca leaf , cocaine, heroin, and opium. Psychotropic substances include ecstasy,2...cocaine is far more difficult to detect than the 300 to 500 kilograms of coca leaf that are required to make that same kilogram. Also, because crops...for legalizing the production and sale of coca leaf , which is currently an internationally controlled narcotic substance? And how can the United

A Message Exchange Protocol in Command and Control Systems Integration, using the JC3IEDM

DTIC Science & Technology

2014-06-01

19TH International Command and Control Research and Technology Symposium C2 Agility: Lessons Learned from Research and Operations. A Message...distribution unlimited 13. SUPPLEMENTARY NOTES Presented at the 18th International Command & Control Research & Technology Symposium (ICCRTS) held 16...presents approaches of integration, compares their technologies , points out their advantages, proposes requirements, and provides the design of a protocol

40 CFR 1042.650 - Exemptions for migratory vessels and auxiliary engines on Category 3 vessels.

Code of Federal Regulations, 2012 CFR

2012-07-01

... PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE... applicable certification requirements for international safety pursuant to the U.S. Coast Guard and the International Convention for the Protection of Life at Sea (SOLAS). The vessel owner must maintain compliance...

40 CFR 1042.650 - Exemptions for migratory vessels and auxiliary engines on Category 3 vessels.

Code of Federal Regulations, 2014 CFR

2014-07-01

... PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE... applicable certification requirements for international safety pursuant to the U.S. Coast Guard and the International Convention for the Protection of Life at Sea (SOLAS). The vessel owner must maintain compliance...

40 CFR 1042.650 - Exemptions for migratory vessels and auxiliary engines on Category 3 vessels.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE... applicable certification requirements for international safety pursuant to the U.S. Coast Guard and the International Convention for the Protection of Life at Sea (SOLAS). The vessel owner must maintain compliance...

40 CFR 1042.650 - Exemptions for migratory vessels and auxiliary engines on Category 3 vessels.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE MARINE... applicable certification requirements for international safety pursuant to the U.S. Coast Guard and the International Convention for the Protection of Life at Sea (SOLAS). The vessel owner must maintain compliance...

Specifications of the International Cooperation Administration for DDT water-dispersible powder for use in malaria control programmes

PubMed Central

Pearce, George W.; Gooden, E. L.; Johnson, Donald R.

1959-01-01

Background information is presented on the development of specifications for 75% DDT water-dispersible powder for use in malaria control programmes supported by the International Cooperation Administration (ICA) of the United States Government. Early difficulties with DDT powders used in these programmes were investigated and it was found that the most critical requirements involved packaging, suspensibility and storage stability. ICA specifications were evolved to meet these requirements. The suspensibility test developed is described, and the importance of inspection of the material procured is discussed. PMID:14431217

Real-Time Operation of the International Space Station

NASA Astrophysics Data System (ADS)

Suffredini, M. T.

2002-01-01

The International Space Station is on orbit and real-time operations are well underway. Along with the assembly challenges of building and operating the International Space Station , scientific activities are also underway. Flight control teams in three countries are working together as a team to plan, coordinate and command the systems on the International Space Station.Preparations are being made to add the additional International Partner elements including their operations teams and facilities. By October 2002, six Expedition crews will have lived on the International Space Station. Management of real-time operations has been key to these achievements. This includes the activities of ground teams in control centers around the world as well as the crew on orbit. Real-time planning is constantly challenged with balancing the requirements and setting the priorities for the assembly, maintenance, science and crew health functions on the International Space Station. It requires integrating the Shuttle, Soyuz and Progress requirements with the Station. It is also necessary to be able to respond in case of on-orbit anomalies and to set plans and commands in place to ensure the continues safe operation of the Station. Bringing together the International Partner operations teams has been challenging and intensely rewarding. Utilization of the assets of each partner has resulted in efficient solutions to problems. This paper will describe the management of the major real-time operations processes, significant achievements, and future challenges.

Neural network-based position synchronised internal force control scheme for cooperative manipulator system

NASA Astrophysics Data System (ADS)

Wang, Jin; Xu, Fan; Lu, GuoDong

2017-09-01

More complex problems of simultaneous position and internal force control occur with cooperative manipulator systems than that of a single one. In the presence of unwanted parametric and modelling uncertainties as well as external disturbances, a decentralised position synchronised force control scheme is proposed. With a feedforward neural network estimating engine, a precise model of the system dynamics is not required. Unlike conventional cooperative or synchronised controllers, virtual position and virtual synchronisation errors are introduced for internal force tracking control and task space position synchronisation. Meanwhile joint space synchronisation and force measurement are unnecessary. Together with simulation studies and analysis, the position and the internal force errors are shown to asymptotically converge to zero. Moreover, the controller exhibits different characteristics with selected synchronisation factors. Under certain settings, it can deal with temporary cooperation by an intelligent retreat mechanism, where less internal force would occur and rigid collision can be avoided. Using a Lyapunov stability approach, the controller is proven to be robust in face of the aforementioned uncertainties.

Compact vibration isolation and suspension for Australian International Gravitational Observatory: Local control system

NASA Astrophysics Data System (ADS)

Dumas, Jean-Charles; Barriga, Pablo; Zhao, Chunnong; Ju, Li; Blair, David G.

2009-11-01

High performance vibration isolators are required for ground based gravitational wave detectors. To attain very high performance at low frequencies we have developed multistage isolators for the proposed Australian International Gravitational Observatory detector in Australia. New concepts in vibration isolation including self-damping, Euler springs, LaCoste springs, Roberts linkages, and double preisolation require novel sensors and actuators. Double preisolation enables internal feedback to be used to suppress low frequency seismic noise. Multidegree of freedom control systems are required to attain high performance. Here we describe the control components and control systems used to control all degrees of freedom. Feedback forces are injected at the preisolation stages and at the penultimate suspension stage. There is no direct actuation on test masses. A digital local control system hosted on a digital signal processor maintains alignment and position, corrects drifts, and damps the low frequency linear and torsional modes without exciting the very high Q-factor test mass suspension. The control system maintains an optical cavity locked to a laser with a high duty cycle even in the absence of an autoalignment system. An accompanying paper presents the mechanics of the system, and the optical cavity used to determine isolation performance. A feedback method is presented, which is expected to improve the residual motion at 1 Hz by more than one order of magnitude.

Compact vibration isolation and suspension for Australian International Gravitational Observatory: local control system.

PubMed

Dumas, Jean-Charles; Barriga, Pablo; Zhao, Chunnong; Ju, Li; Blair, David G

2009-11-01

High performance vibration isolators are required for ground based gravitational wave detectors. To attain very high performance at low frequencies we have developed multistage isolators for the proposed Australian International Gravitational Observatory detector in Australia. New concepts in vibration isolation including self-damping, Euler springs, LaCoste springs, Roberts linkages, and double preisolation require novel sensors and actuators. Double preisolation enables internal feedback to be used to suppress low frequency seismic noise. Multidegree of freedom control systems are required to attain high performance. Here we describe the control components and control systems used to control all degrees of freedom. Feedback forces are injected at the preisolation stages and at the penultimate suspension stage. There is no direct actuation on test masses. A digital local control system hosted on a digital signal processor maintains alignment and position, corrects drifts, and damps the low frequency linear and torsional modes without exciting the very high Q-factor test mass suspension. The control system maintains an optical cavity locked to a laser with a high duty cycle even in the absence of an autoalignment system. An accompanying paper presents the mechanics of the system, and the optical cavity used to determine isolation performance. A feedback method is presented, which is expected to improve the residual motion at 1 Hz by more than one order of magnitude.

Inter-Module Ventilation Changes to the International Space Station Vehicle to Support Integration of the International Docking Adapter and Commercial Crew Vehicles

NASA Technical Reports Server (NTRS)

Link, Dwight E., Jr.; Balistreri, Steven F., Jr.

2015-01-01

The International Space Station (ISS) Environmental Control and Life Support System (ECLSS) is continuing to evolve in the post-Space Shuttle era. The ISS vehicle configuration that is in operation was designed for docking of a Space Shuttle vehicle, and designs currently under development for commercial crew vehicles require different interfaces. The ECLSS Temperature and Humidity Control Subsystem (THC) Inter-Module Ventilation (IMV) must be modified in order to support two docking interfaces at the forward end of ISS, to provide the required air exchange. Development of a new higher-speed IMV fan and extensive ducting modifications are underway to support the new Commercial Crew Vehicle interfaces. This paper will review the new ECLSS IMV development requirements, component design and hardware status, subsystem analysis and testing performed to date, and implementation plan to support Commercial Crew Vehicle docking.

76 FR 53817 - Minimum Internal Control Standards for Class II Gaming

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-30

... Accounting, Gambling, Indians--lands, Reporting and recordkeeping requirements. 25 CFR Part 543 Administrative practice and procedure, Gambling, Indians--lands, Reporting and recordkeeping requirements. For...

Internalizing versus Externalizing Control: Different Ways to Perform a Time-Based Prospective Memory Task

ERIC Educational Resources Information Center

Huang, Tracy; Loft, Shayne; Humphreys, Michael S.

2014-01-01

"Time-based prospective memory" (PM) refers to performing intended actions at a future time. Participants with time-based PM tasks can be slower to perform ongoing tasks (costs) than participants without PM tasks because internal control is required to maintain the PM intention or to make prospective-timing estimates. However, external…

75 FR 57385 - Internal Control Over Financial Reporting in Exchange Act Periodic Reports of Non-Accelerated Filers

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

... attestation report of its registered public accounting firm on internal control over financial reporting in... definition of either an ``accelerated filer'' or a ``large accelerated filer'' under Exchange Act Rule 12b-2..., for both definitions, the issuer needs to have been subject to reporting requirements for at least...

78 FR 14080 - Kolcraft Enterprises, Inc., Provisional Acceptance of a Settlement Agreement and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-04

..., and when a child pushes against the rail, the rail can unlatch unexpectedly, posing a fall hazard to... enforce a system of internal controls and procedures designed to ensure that: (i) Information required to... weaknesses in the design or operation of such internal controls that are reasonably likely to adversely...

40 CFR 63.771 - Control equipment requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... includes openings necessary to equalize or balance the internal pressure of the unit following changes in....g., carbon adsorption system or condenser) or other control device that is designed and operated to... compliance according to the requirements of § 63.772(f) or (g), as applicable. (5) For each carbon adsorption...

40 CFR 63.771 - Control equipment requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... includes openings necessary to equalize or balance the internal pressure of the unit following changes in....g., carbon adsorption system or condenser) or other control device that is designed and operated to... compliance according to the requirements of § 63.772(f) or (g), as applicable. (5) For each carbon adsorption...

40 CFR 63.771 - Control equipment requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... includes openings necessary to equalize or balance the internal pressure of the unit following changes in....g., carbon adsorption system or condenser) or other control device that is designed and operated to... compliance according to the requirements of § 63.772(f) or (g), as applicable. (5) For each carbon adsorption...

46 CFR 113.30-5 - Requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SYSTEMS AND EQUIPMENT Internal Communications § 113.30-5 Requirements. (a) Communication. Each vessel must... engine control room. (6) Control room, if the vessel is a mobile offshore drilling unit. (7) The... or spaces used by the emergency squad are not next to the navigating bridge or, on a mobile offshore...

Single subject controlled experiments in aphasia: The science and the state of the science

PubMed Central

Thompson, Cynthia K.

2007-01-01

This paper discusses the use of single subject controlled experimental designs for investigating the effect of treatment for aphasia. A brief historical perspective is presented, followed by discussions of the advantages and disadvantages of single subject and group approaches, the basic requirements of single subject experimental research, and crucial considerations in design selection. In the final sections, results of reviews of published single subject controlled experiments are discussed, with emphasis on internal validity issues, the number of participants enrolled in published studies, operational specification of the dependent and independent variables, and reliability of measurement. Learning outcomes As a result of reading this paper, the participant will: (1) understand the mechanisms required for demonstration of internal and external validity using single subject controlled experimental designs, (2) become familiar with the basic requirements of single subject controlled experimental research, (3) understand the types of single subject controlled experimental designs that are the most appropriate for studying the effects of treatment for aphasia, and (4) become familiar with trends in the published aphasia treatment literature in which single subject controlled experimental designs have been used. PMID:16635494

Evolution of activities in international biological standardization since the early days of the Health Organisation of the League of Nations.

PubMed

Sizaret, P

1988-01-01

The main activities in international biological standardization during the 18 years that followed the first international biological standardization meeting in London in 1921 were concerned with expressing the potencies of test preparations in comparison with reference materials. After the Second World War, however, it became clear that the testing of biological substances against international reference materials was only one among several measures for obtaining safe and potent products. The activities in international biological standardization were therefore widened so that, by the strict observance of specific manufacturing and control requirements, it was possible to gain further in safety and efficacy. At the end of 1987, 42 international requirements for biological substances were available and were being used as national requirements, sometimes after minor modification, by the majority of WHO's Member States. This is of utmost importance for the worldwide use of safe and potent biological products, including vaccines.

Nuclear materials control and accountability (NMC and A) auditors in the 90's

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barham, M.A.; Abbott, R.R.

1991-01-01

The increase in emphasis on the adequacy of the NMC and A internal control systems requires that management define what type of training and experience is needed by NMC and A Internal Audit Program. At Martin Marietta Energy Systems, inc. (the prime contractor for the Department of Energy at Oak Ridge, Tenn.), the Central NMC and A Manager has developed a comprehensive set of NMC and A Internal Audit policies that defines performance standards, methods of conducting audits, mechanisms for ensuring appropriate independence for NMC and A auditors, structure for standardized audit reports and working papers, and a section thatmore » addresses the development of training plans for individual NMC and A auditors. The training requirements reflect the unique combination of skills necessary to be an effective NMC and A Internal Auditor- a combination of the operational auditing skills of a Certified Internal Auditor, the accounting auditing capabilities of a Certified Public Accountant, and the specific technical knowledge base associated with nuclear materials. This paper presents a mechanism for identifying an individual training program for NMC and A auditors that considers the above requirements and the individual's long-range career goals.« less

Implementation of Energy Code Controls Requirements in New Commercial Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenberg, Michael I.; Hart, Philip R.; Hatten, Mike

Most state energy codes in the United States are based on one of two national model codes; ANSI/ASHRAE/IES 90.1 (Standard 90.1) or the International Code Council (ICC) International Energy Conservation Code (IECC). Since 2004, covering the last four cycles of Standard 90.1 updates, about 30% of all new requirements have been related to building controls. These requirements can be difficult to implement and verification is beyond the expertise of most building code officials, yet the assumption in studies that measure the savings from energy codes is that they are implemented and working correctly. The objective of the current research ismore » to evaluate the degree to which high impact controls requirements included in commercial energy codes are properly designed, commissioned and implemented in new buildings. This study also evaluates the degree to which these control requirements are realizing their savings potential. This was done using a three-step process. The first step involved interviewing commissioning agents to get a better understanding of their activities as they relate to energy code required controls measures. The second involved field audits of a sample of commercial buildings to determine whether the code required control measures are being designed, commissioned and correctly implemented and functioning in new buildings. The third step includes compilation and analysis of the information gather during the first two steps. Information gathered during these activities could be valuable to code developers, energy planners, designers, building owners, and building officials.« less

Analysis of the Parameters Required for Performance Monitoring and Assessment of Military Communications Systems by Military Technical Controller

DTIC Science & Technology

1975-12-01

139 APPENDIX A* BASIC CONCEPT OF MILITARY TECHNICAL CONTROL.142 6 APIENDIX Es TEST EQUIPMENI REQUIRED FOR lEASURF.4ENr OF 1AF’AMETE RS...Control ( SATEC ) Automatic Facilities heport Army Automated Quality Monitoring Reporting System (AQMPS) Army Autcmated Technical Control-Semi (ATC-Semi...technical control then beco.. es equipment status monitoring. All the major equipment in a system wculd have internal sensors with properly selected parameters

Spinal motor control system incorporates an internal model of limb dynamics.

PubMed

Shimansky, Y P

2000-10-01

The existence and utilization of an internal representation of the controlled object is one of the most important features of the functioning of neural motor control systems. This study demonstrates that this property already exists at the level of the spinal motor control system (SMCS), which is capable of generating motor patterns for reflex rhythmic movements, such as locomotion and scratching, without the aid of the peripheral afferent feedback, but substantially modifies the generated activity in response to peripheral afferent stimuli. The SMCS is presented as an optimal control system whose optimality requires that it incorporate an internal model (IM) of the controlled object's dynamics. A novel functional mechanism for the integration of peripheral sensory signals with the corresponding predictive output from the IM, the summation of information precision (SIP) is proposed. In contrast to other models in which the correction of the internal representation of the controlled object's state is based on the calculation of a mismatch between the internal and external information sources, the SIP mechanism merges the information from these sources in order to optimize the precision of the controlled object's state estimate. It is demonstrated, based on scratching in decerebrate cats as an example of the spinal control of goal-directed movements, that the results of computer modeling agree with the experimental observations related to the SMCS's reactions to phasic and tonic peripheral afferent stimuli. It is also shown that the functional requirements imposed by the mathematical model of the SMCS comply with the current knowledge about the related properties of spinal neuronal circuitry. The crucial role of the spinal presynaptic inhibition mechanism in the neuronal implementation of SIP is elucidated. Important differences between the IM and a state predictor employed for compensating for a neural reflex time delay are discussed.

External Contamination Control of Attached Payloads on the International Space Station

NASA Technical Reports Server (NTRS)

Soares, Carlos E.; Mikatarian, Ronald R.; Olsen, Randy L.; Huang, Alvin Y.; Steagall, Courtney A.; Schmidl, William D.; Wright, Bruce D.; Koontz, Steven

2012-01-01

The International Space Station (ISS) is an on-orbit platform for science utilization in low Earth orbit with multiple sites for external payloads with exposure to the natural and induced environments. Contamination is one of the induced environments that can impact performance, mission success and science utilization on the vehicle. This paper describes the external contamination control requirements and integration process for externally mounted payloads on the ISS. The external contamination control requirements are summarized and a description of the integration and verification process is detailed to guide payload developers in the certification process of attached payloads on the vehicle. A description of the required data certification deliverables covers the characterization of contamination sources. Such characterization includes identification, usage and operational data for each class of contamination source. Classes of external contamination sources covered are vacuum exposed materials, sources of leakage, vacuum venting and thrusters. ISS system level analyses are conducted by the ISS Space Environments Team to certify compliance with external contamination control requirements. This paper also addresses the ISS induced contamination environment at attached payload sites, both at the requirements level as well as measurements made on ISS.

12 CFR 217.122 - Qualification requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... related processes; (ii) Have and document a process (which must capture business environment and internal... current business activities, risk profile, technological processes, and risk management processes; and (ii... assessment systems. (D) Business environment and internal control factors. The Board-regulated institution...

12 CFR 3.122 - Qualification requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... related processes; (ii) Have and document a process (which must capture business environment and internal... association's current business activities, risk profile, technological processes, and risk management...) Business environment and internal control factors. The national bank or Federal savings association must...

12 CFR 324.122 - Qualification requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... related processes; (ii) Have and document a process (which must capture business environment and internal... current business activities, risk profile, technological processes, and risk management processes; and (ii... assessment systems. (D) Business environment and internal control factors. The FDIC-supervised institution...

A "Kanes's Dynamics" Model for the Active Rack Isolation System

NASA Technical Reports Server (NTRS)

Hampton, R. David; Beech, Geoffrey

1999-01-01

Many microgravity space-science experiments require vibratory acceleration levels unachievable without active isolation. The Boeing Corporation's Active Rack Isolation System (ARIS) employs a novel combination of magnetic actuation and mechanical linkages, to address these isolation requirements on the International Space Station (ISS). ARIS provides isolation at the rack (international Standard Payload Rack, or ISPR) level. Effective model-based vibration isolation requires (1) an appropriate isolation device, (2) an adequate dynamic (i.e., mathematical) model of that isolator, and (3) a suitable, corresponding controller. ARIS provides the ISS response to the first requirement. This paper presents one response to the second, in a state-space framework intended to facilitate an optimal-controls approach to the third. The authors use "Kane's Dynamics" to develop an state-space, analytical (algebraic) set of linearized equations of motion for ARIS.

A "Kane's Dynamics" Model for the Active Rack Isolation System

NASA Technical Reports Server (NTRS)

Hampton, R. D.; Beech, G. S.; Rao, N. N. S.; Rupert, J. K.; Kim, Y. K.

2001-01-01

Many microgravity space science experiments require vibratory acceleration levels unachievable without active isolation. The Boeing Corporation's Active Rack Isolation System (ARIS) employs a novel combination of magnetic actuation and mechanical linkages to address these isolation requirements on the International Space Station (ISS). ARIS provides isolation at the rack (International Standard Payload Rack (ISPR)) level. Effective model-based vibration isolation requires: (1) an appropriate isolation device, (2) an adequate dynamic (i.e., mathematical) model of that isolator, and (3) a suitable, corresponding controller. ARIS provides the ISS response to the first requirement. This paper presents one response to the second, in a state space framework intended to facilitate an optimal-controls approach to the third. The authors use "Kane's Dynamics" to develop a state-space, analytical (algebraic) set of linearized equations of motion for ARIS.

International Space Station US. GN&C Momentum Manager Controller Design for Shuttle Thermal Protection System Repair

NASA Technical Reports Server (NTRS)

Sims, Christopher R.

2005-01-01

This paper describes the design of the ISS Momentum Manager controllers for the Orbiter Repair Maneuver (ORM) and Orbiter Tile Repair operations. Momentum Manager Controllers provide non-propulsive attitude control via CMGs. Non-propulsive control is required at the beginning and the middle of the ORM and at the tile repair position. This paper first reviews the design issues and requirements, then presents the design methodology, and concludes with analysis results that verify the design.

Unlabeled oligonucleotides as internal temperature controls for genotyping by amplicon melting.

PubMed

Seipp, Michael T; Durtschi, Jacob D; Liew, Michael A; Williams, Jamie; Damjanovich, Kristy; Pont-Kingdon, Genevieve; Lyon, Elaine; Voelkerding, Karl V; Wittwer, Carl T

2007-07-01

Amplicon melting is a closed-tube method for genotyping that does not require probes, real-time analysis, or allele-specific polymerase chain reaction. However, correct differentiation of homozygous mutant and wild-type samples by melting temperature (Tm) requires high-resolution melting and closely controlled reaction conditions. When three different DNA extraction methods were used to isolate DNA from whole blood, amplicon Tm differences of 0.03 to 0.39 degrees C attributable to the extractions were observed. To correct for solution chemistry differences between samples, complementary unlabeled oligonucleotides were included as internal temperature controls to shift and scale the temperature axis of derivative melting plots. This adjustment was applied to a duplex amplicon melting assay for the methylenetetrahydrofolate reductase variants 1298A>C and 677C>T. High- and low-temperature controls bracketing the amplicon melting region decreased the Tm SD within homozygous genotypes by 47 to 82%. The amplicon melting assay was 100% concordant to an adjacent hybridization probe (HybProbe) melting assay when temperature controls were included, whereas a 3% error rate was observed without temperature correction. In conclusion, internal temperature controls increase the accuracy of genotyping by high-resolution amplicon melting and should also improve results on lower resolution instruments.

International Drug Control Policy

DTIC Science & Technology

2008-06-23

domestic law or international drug control agreements. Narcotic drugs include cannabis, cannabis resin, coca leaf , cocaine, heroin, and opium...differently, a kilogram of powder cocaine is far more difficult to detect than the 300 to 500 kilograms of coca leaf that are required to make that same...1961 Convention gave countries practicing coca leaf chewing 25 years following the Convention’s entry into force to abolish coca leaf chewing. 85 See

Strengthening core public health capacity based on the implementation of the International Health Regulations (IHR) (2005): Chinese lessons

PubMed Central

Liu, Bin; Sun, Yan; Dong, Qian; Zhang, Zongjiu; Zhang, Liang

2015-01-01

As an international legal instrument, the International Health Regulations (IHR) is internationally binding in 196 countries, especially in all the member states of the World Health Organization (WHO). The IHR aims to prevent, protect against, control, and respond to the international spread of disease and aims to cut out unnecessary interruptions to traffic and trade. To meet IHR requirements, countries need to improve capacity construction by developing, strengthening, and maintaining core response capacities for public health risk and Public Health Emergency of International Concern (PHEIC). In addition, all the related core capacity requirements should be met before June 15, 2012. If not, then the deadline can be extended until 2016 upon request by countries. China has promoted the implementation of the IHR comprehensively, continuingly strengthening the core public health capacity and advancing in core public health emergency capacity building, points of entry capacity building, as well as risk prevention and control of biological events (infectious diseases, zoonotic diseases, and food safety), radiological, nuclear, and chemical events, and other catastrophic events. With significant progress in core capacity building, China has dealt with many public health emergencies successfully, ensuring that its core public health capacity has met the IHR requirements, which was reported to WHO in June 2014. This article describes the steps, measures, and related experiences in the implementation of IHR in China. PMID:26029897

76 FR 58315 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... internal controls, and do not necessarily require internal auditors to perform the internal audit function... clarify the Exchange's current ability to retain a third party auditor through codification in the By... undertaken by a third-party auditor retained to perform all or a portion of the Exchange's audit function. 2...

76 FR 58317 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... internal controls, and do not necessarily require internal auditors to perform the internal audit function... clarify the Exchange's current ability to retain a third party auditor through codification in the By... undertaken by a third-party auditor retained to perform all or a portion of the Exchange's audit function. 2...

Convention on International Trade in Endangered Species of Wild Fauna and Flora.

ERIC Educational Resources Information Center

Supplement to IUCN Bulletin, 1973

1973-01-01

Concern for the endangered species of wild animals and plants of the world prompted the drafting of this international convention regulating the import, export, and re-export of such species. Nations signing this document are required to impose strict controls on the international trade of these plants and animals or their recognizable parts. The…

A network architecture for International Business Satellite communications

NASA Astrophysics Data System (ADS)

Takahata, Fumio; Nohara, Mitsuo; Takeuchi, Yoshio

Demand Assignment (DA) control is expected to be introduced in the International Business Satellte communications (IBS) network in order to cope with a growing international business traffic. The paper discusses the DA/IBS network from the viewpoints of network configuration, satellite channel configuration and DA control. The network configuration proposed here consists of one Central Station with network management function and several Network Coordination Stations with user management function. A satellite channel configuration is also presented along with a tradeoff study on transmission bit rate, high power amplifier output power requirement, and service quality. The DA control flow and protocol based on CCITT Signalling System No. 7 are also proposed.

40 CFR 1065.630 - 1980 international gravity formula.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false 1980 international gravity formula. 1065.630 Section 1065.630 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Calculations and Data Requirements § 1065.630 1980...

40 CFR 1065.630 - 1980 international gravity formula.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false 1980 international gravity formula. 1065.630 Section 1065.630 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Calculations and Data Requirements § 1065.630 1980...

40 CFR 1065.630 - 1980 international gravity formula.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 34 2012-07-01 2012-07-01 false 1980 international gravity formula. 1065.630 Section 1065.630 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Calculations and Data Requirements § 1065.630 1980...

40 CFR 1065.630 - 1980 international gravity formula.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 34 2013-07-01 2013-07-01 false 1980 international gravity formula. 1065.630 Section 1065.630 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Calculations and Data Requirements § 1065.630 1980...

47 CFR 90.203 - Certification required.

Code of Federal Regulations, 2012 CFR

2012-10-01

... manufacturer, service or maintenance personnel, using the equipment's external operation controls. (f) Except... been approved prior to January 15, 1988, and that permit the operator, by using external controls, to... such that transmitters with external controls normally available to the operator must be internally...

47 CFR 90.203 - Certification required.

Code of Federal Regulations, 2011 CFR

2011-10-01

... manufacturer, service or maintenance personnel, using the equipment's external operation controls. (f) Except... been approved prior to January 15, 1988, and that permit the operator, by using external controls, to... such that transmitters with external controls normally available to the operator must be internally...

17 CFR 240.13a-15 - Controls and procedures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... based must be a suitable, recognized control framework that is established by a body or group that has..., without limitation, controls and procedures designed to ensure that information required to be disclosed... disclosure. (f) The term internal control over financial reporting is defined as a process designed by, or...

17 CFR 240.15d-15 - Controls and procedures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... control framework that is established by a body or group that has followed due-process procedures..., without limitation, controls and procedures designed to ensure that information required to be disclosed... disclosure. (f) The term internal control over financial reporting is defined as a process designed by, or...

17 CFR 240.15d-15 - Controls and procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... control framework that is established by a body or group that has followed due-process procedures..., without limitation, controls and procedures designed to ensure that information required to be disclosed... disclosure. (f) The term internal control over financial reporting is defined as a process designed by, or...

17 CFR 240.13a-15 - Controls and procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... based must be a suitable, recognized control framework that is established by a body or group that has..., without limitation, controls and procedures designed to ensure that information required to be disclosed... disclosure. (f) The term internal control over financial reporting is defined as a process designed by, or...

46 CFR 62.25-15 - Safety control systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... manual safety trip controls must be provided for all main boilers, turbines, and internal combustion... 46 Shipping 2 2012-10-01 2012-10-01 false Safety control systems. 62.25-15 Section 62.25-15... AUTOMATION General Requirements for All Automated Vital Systems § 62.25-15 Safety control systems. (a...

46 CFR 62.25-15 - Safety control systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... manual safety trip controls must be provided for all main boilers, turbines, and internal combustion... 46 Shipping 2 2013-10-01 2013-10-01 false Safety control systems. 62.25-15 Section 62.25-15... AUTOMATION General Requirements for All Automated Vital Systems § 62.25-15 Safety control systems. (a...

46 CFR 62.25-15 - Safety control systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... manual safety trip controls must be provided for all main boilers, turbines, and internal combustion... 46 Shipping 2 2014-10-01 2014-10-01 false Safety control systems. 62.25-15 Section 62.25-15... AUTOMATION General Requirements for All Automated Vital Systems § 62.25-15 Safety control systems. (a...

Revision of Import and Export Requirements for Controlled Substances, Listed Chemicals, and Tableting and Encapsulating Machines, Including Changes To Implement the International Trade Data System (ITDS); Revision of Reporting Requirements for Domestic Transactions in Listed Chemicals and Tableting and Encapsulating Machines; and Technical Amendments. Final rule.

PubMed

2016-12-30

The Drug Enforcement Administration is updating its regulations for the import and export of tableting and encapsulating machines, controlled substances, and listed chemicals, and its regulations relating to reports required for domestic transactions in listed chemicals, gamma-hydroxybutyric acid, and tableting and encapsulating machines. In accordance with Executive Order 13563, the Drug Enforcement Administration has reviewed its import and export regulations and reporting requirements for domestic transactions in listed chemicals (and gamma-hydroxybutyric acid) and tableting and encapsulating machines, and evaluated them for clarity, consistency, continued accuracy, and effectiveness. The amendments clarify certain policies and reflect current procedures and technological advancements. The amendments also allow for the implementation, as applicable to tableting and encapsulating machines, controlled substances, and listed chemicals, of the President's Executive Order 13659 on streamlining the export/import process and requiring the government-wide utilization of the International Trade Data System (ITDS). This rule additionally contains amendments that implement recent changes to the Controlled Substances Import and Export Act (CSIEA) for reexportation of controlled substances among members of the European Economic Area made by the Improving Regulatory Transparency for New Medical Therapies Act. The rule also includes additional substantive and technical and stylistic amendments.

International Space Station (ISS) Node 1 Environmental Control and Life Support (ECLS) System Keep Out Zone On-Orbit Problems

NASA Technical Reports Server (NTRS)

Williams, David E.

2004-01-01

The International Space Station (ISS) Environmental Control and Life Support (ECLS) system performance can be impacted by operations on ISS. This is especially important for the Temperature and Humidity Control (THC) and for the Fire Detection and Suppression (FDS) subsystems. It is also more important for Node 1 since it has become a convenient area for many crew tasks and for stowing hardware prior to Shuttle arrival. This paper will discuss the current requirements for ECLS keep out zones in Node 1; the issues with stowage in Node 1 during Increment 7 and how they impacted the keep out zone requirements; and the solution during Increment 7 and 8 for maintaining the keep out zones in Node 1.

Unlabeled Oligonucleotides as Internal Temperature Controls for Genotyping by Amplicon Melting

PubMed Central

Seipp, Michael T.; Durtschi, Jacob D.; Liew, Michael A.; Williams, Jamie; Damjanovich, Kristy; Pont-Kingdon, Genevieve; Lyon, Elaine; Voelkerding, Karl V.; Wittwer, Carl T.

2007-01-01

Amplicon melting is a closed-tube method for genotyping that does not require probes, real-time analysis, or allele-specific polymerase chain reaction. However, correct differentiation of homozygous mutant and wild-type samples by melting temperature (Tm) requires high-resolution melting and closely controlled reaction conditions. When three different DNA extraction methods were used to isolate DNA from whole blood, amplicon Tm differences of 0.03 to 0.39°C attributable to the extractions were observed. To correct for solution chemistry differences between samples, complementary unlabeled oligonucleotides were included as internal temperature controls to shift and scale the temperature axis of derivative melting plots. This adjustment was applied to a duplex amplicon melting assay for the methylenetetrahydrofolate reductase variants 1298A>C and 677C>T. High- and low-temperature controls bracketing the amplicon melting region decreased the Tm SD within homozygous genotypes by 47 to 82%. The amplicon melting assay was 100% concordant to an adjacent hybridization probe (HybProbe) melting assay when temperature controls were included, whereas a 3% error rate was observed without temperature correction. In conclusion, internal temperature controls increase the accuracy of genotyping by high-resolution amplicon melting and should also improve results on lower resolution instruments. PMID:17591926

Strengthening core public health capacity based on the implementation of the International Health Regulations (IHR) (2005): Chinese lessons.

PubMed

Liu, Bin; Sun, Yan; Dong, Qian; Zhang, Zongjiu; Zhang, Liang

2015-04-17

As an international legal instrument, the International Health Regulations (IHR) is internationally binding in 196 countries, especially in all the member states of the World Health Organization (WHO). The IHR aims to prevent, protect against, control, and respond to the international spread of disease and aims to cut out unnecessary interruptions to traffic and trade. To meet IHR requirements, countries need to improve capacity construction by developing, strengthening, and maintaining core response capacities for public health risk and Public Health Emergency of International Concern (PHEIC). In addition, all the related core capacity requirements should be met before June 15, 2012. If not, then the deadline can be extended until 2016 upon request by countries. China has promoted the implementation of the IHR comprehensively, continuingly strengthening the core public health capacity and advancing in core public health emergency capacity building, points of entry capacity building, as well as risk prevention and control of biological events (infectious diseases, zoonotic diseases, and food safety), radiological, nuclear, and chemical events, and other catastrophic events. With significant progress in core capacity building, China has dealt with many public health emergencies successfully, ensuring that its core public health capacity has met the IHR requirements, which was reported to WHO in June 2014. This article describes the steps, measures, and related experiences in the implementation of IHR in China. © 2015 by Kerman University of Medical Sciences.

17 CFR 240.17i-5 - Record creation, maintenance, and access requirements for supervised investment bank holding...

Code of Federal Regulations, 2010 CFR

2010-04-01

... shall make and keep current the following records: (1) A record reflecting the results of stress tests...; and (5) Records documenting the system of internal risk management controls required to be established...

17 CFR 240.17i-5 - Record creation, maintenance, and access requirements for supervised investment bank holding...

Code of Federal Regulations, 2013 CFR

2013-04-01

... shall make and keep current the following records: (1) A record reflecting the results of stress tests...; and (5) Records documenting the system of internal risk management controls required to be established...

17 CFR 240.17i-5 - Record creation, maintenance, and access requirements for supervised investment bank holding...

Code of Federal Regulations, 2012 CFR

2012-04-01

... shall make and keep current the following records: (1) A record reflecting the results of stress tests...; and (5) Records documenting the system of internal risk management controls required to be established...

17 CFR 240.17i-5 - Record creation, maintenance, and access requirements for supervised investment bank holding...

Code of Federal Regulations, 2011 CFR

2011-04-01

... shall make and keep current the following records: (1) A record reflecting the results of stress tests...; and (5) Records documenting the system of internal risk management controls required to be established...

[Incorporation of the Hazard Analysis and Critical Control Point system (HACCP) in food legislation].

PubMed

Castellanos Rey, Liliana C; Villamil Jiménez, Luis C; Romero Prada, Jaime R

2004-01-01

The Hazard Analysis and Critical Control Point system (HACCP), recommended by different international organizations as the Codex Alimentarius Commission, the World Trade Organization (WTO), the International Office of Epizootics (OIE) and the International Convention for Vegetables Protection (ICPV) amongst others, contributes to ensuring the innocuity of food along the agro-alimentary chain and requires of Good Manufacturing Practices (GMP) for its implementation, GMP's which are legislated in most countries. Since 1997, Colombia has set rules and legislation for application of HACCP system in agreement with international standards. This paper discusses the potential and difficulties of the legislation enforcement and suggests some policy implications towards food safety.

Microscope-Based Fluid Physics Experiments in the Fluids and Combustion Facility on ISS

NASA Technical Reports Server (NTRS)

Doherty, Michael P.; Motil, Susan M.; Snead, John H.; Malarik, Diane C.

2000-01-01

At the NASA Glenn Research Center, the Microgravity Science Program is planning to conduct a large number of experiments on the International Space Station in both the Fluid Physics and Combustion Science disciplines, and is developing flight experiment hardware for use within the International Space Station's Fluids and Combustion Facility. Four fluids physics experiments that require an optical microscope will be sequentially conducted within a subrack payload to the Fluids Integrated Rack of the Fluids and Combustion Facility called the Light Microscopy Module, which will provide the containment, changeout, and diagnostic capabilities to perform the experiments. The Light Microscopy Module is planned as a fully remotely controllable on-orbit microscope facility, allowing flexible scheduling and control of experiments within International Space Station resources. This paper will focus on the four microscope-based experiments, specifically, their objectives and the sample cell and instrument hardware to accommodate their requirements.

Clearing the Air: Applied Linguistic Perspectives on Aviation Communication

ERIC Educational Resources Information Center

Read, John; Knoch, Ute

2009-01-01

As a result of investigations showing that communication problems can be a significant contributing factor to major aviation accidents, the International Civil Aviation Organization (ICAO) has established a set of Language Proficiency Requirements. All pilots and air traffic controllers engaged in international aviation must be certified by their…

Pollutant Emissions and Energy Efficiency under Controlled Conditions for Household Biomass Cookstoves and Implications for Metrics Useful in Setting International Test Standards

EPA Science Inventory

Realistic metrics and methods for testing household biomass cookstoves are required to develop standards needed by international policy makers, donors, and investors. Application of consistent test practices allows emissions and energy efficiency performance to be benchmarked and...

17 CFR 240.17i-6 - Reporting requirements for supervised investment bank holding companies.

Code of Federal Regulations, 2010 CFR

2010-04-01

... condition, risk management system, and transactions and relationships among members of the affiliate group... Oversight Board; and (ii) A supplemental report entitled “Accountant's Report on Internal Risk Management.... 7201(a)(12)) indicating the results of the accountant's review of the internal risk management control...

78 FR 33748 - Diisopropyl Adipate; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

... control. That document referenced a summary of the petition prepared by Technology Sciences Group Inc... the adipic acid treated groups were observed at the same levels as in the control groups... products intended for mosquito control. Wellmark International submitted a petition prepared by Technology...

Linear control of the flywheel inverted pendulum.

PubMed

Olivares, Manuel; Albertos, Pedro

2014-09-01

The flywheel inverted pendulum is an underactuated mechanical system with a nonlinear model but admitting a linear approximation around the unstable equilibrium point in the upper position. Although underactuated systems usually require nonlinear controllers, the easy tuning and understanding of linear controllers make them more attractive for designers and final users. In a recent paper, a simple PID controller was proposed by the authors, leading to an internally unstable controlled plant. To achieve global stability, two options are developed here: first by introducing an internal stabilizing controller and second by replacing the PID controller by an observer-based state feedback control. Simulation and experimental results show the effectiveness of the design. Copyright © 2013 ISA. Published by Elsevier Ltd. All rights reserved.

40 CFR Table 10 to Subpart Uuuu of... - Applicability of General Provisions to Subpart UUUU

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements; internal and external QA procedures for testing No. § 63.7(d) Testing Facilities Requirements for....; must keep quality control plan on record for 5 years; keep old versions for 5 years after revisions No...

7 CFR 272.4 - Program administration and personnel requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Administration offices, community action agencies, planning agencies, migrant service organizations, and school... area. (c) Internal controls—(1) Requirements. In order to safeguard certification and issuance records... unit to another, supervisory controls should be sufficient to assure that the unauthorized creation or...

7 CFR 272.4 - Program administration and personnel requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Administration offices, community action agencies, planning agencies, migrant service organizations, and school... area. (c) Internal controls—(1) Requirements. In order to safeguard certification and issuance records... unit to another, supervisory controls should be sufficient to assure that the unauthorized creation or...

7 CFR 272.4 - Program administration and personnel requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Administration offices, community action agencies, planning agencies, migrant service organizations, and school... area. (c) Internal controls—(1) Requirements. In order to safeguard certification and issuance records... unit to another, supervisory controls should be sufficient to assure that the unauthorized creation or...

7 CFR 272.4 - Program administration and personnel requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Administration offices, community action agencies, planning agencies, migrant service organizations, and school... area. (c) Internal controls—(1) Requirements. In order to safeguard certification and issuance records... unit to another, supervisory controls should be sufficient to assure that the unauthorized creation or...

Command and Telemetry Latency Effects on Operator Performance during International Space Station Robotics Operations

NASA Technical Reports Server (NTRS)

Currie, Nancy J.; Rochlis, Jennifer

2004-01-01

International Space Station (ISS) operations will require the on-board crew to perform numerous robotic-assisted assembly, maintenance, and inspection activities. Current estimates for some robotically performed maintenance timelines are disproportionate and potentially exceed crew availability and duty times. Ground-based control of the ISS robotic manipulators, specifically the Special Purpose Dexterous Manipulator (SPDM), is being examined as one potential solution to alleviate the excessive amounts of crew time required for extravehicular robotic maintenance and inspection tasks.

[Prospects in getting accordance between chemical analytic control means and medical technical requirements to safety system concerning chemical weapons destruction].

PubMed

Rembovskiĭ, V R; Mogilenkova, L A; Savel'eva, E I

2005-01-01

The major unit monitoring chemical weapons destruction objects is a system of chemical analyticcontrol over the technologic process procedures and possibility of environment and workplace pollution withtoxicchemicals and their destruction products. At the same time, physical and chemical control means meet sanitary and hygienic requirements incompletely. To provide efficient control, internationally recognized approaches should be adapted to features of Russian system monitoring pollution of chemical weapons destruction objects with toxic chemicals.

COAL CONVERSION CONTROL TECHNOLOGY. VOLUME I. ENVIRONMENTAL REGULATIONS; LIQUID EFFLUENTS

EPA Science Inventory

This volume is the product of an information-gathering effort relating to coal conversion process streams. Available and developing control technology has been evaluated in view of the requirements of present and proposed federal, state, regional, and international environmental ...

COAL CONVERSION CONTROL TECHNOLOGY. VOLUME II. GASEOUS EMISSIONS; SOLID WASTES

EPA Science Inventory

This volume is the product of an information-gathering effort relating to coal conversion process streams. Available and developing control technology has been evaluated in view of the requirements of present and proposed federal, state, regional, and international environmental ...

Dynamics and Control of Attitude, Power, and Momentum for a Spacecraft Using Flywheels and Control Moment Gyroscopes

NASA Technical Reports Server (NTRS)

Roithmayr, Carlos M.; Karlgaard, Christopher D.; Kumar, Renjith R.; Seywald, Hans; Bose, David M.

2003-01-01

Several laws are designed for simultaneous control of the orientation of an Earth-pointing spacecraft, the energy stored by counter-rotating flywheels, and the angular momentum of the flywheels and control moment gyroscopes used together as an integrated set of actuators for attitude control. General, nonlinear equations of motion are presented in vector-dyadic form, and used to obtain approximate expressions which are then linearized in preparation for design of control laws that include feedback of flywheel kinetic energy error as a means of compensating for damping exerted by rotor bearings. Two flywheel steering laws are developed such that torque commanded by an attitude control law is achieved while energy is stored or discharged at the required rate. Using the International Space Station as an example, numerical simulations are performed to demonstrate control about a torque equilibrium attitude, and illustrate the benefits of kinetic energy error feedback. Control laws for attitude hold are also developed, and used to show the amount of propellant that can be saved when flywheels assist the CMGs. Nonlinear control laws for large-angle slew maneuvers perform well, but excessive momentum is required to reorient a vehicle like the International Space Station.

The Minimal Control Principle Predicts Strategy Shifts in the Abstract Decision Making Task

ERIC Educational Resources Information Center

Taatgen, Niels A.

2011-01-01

The minimal control principle (Taatgen, 2007) predicts that people strive for problem-solving strategies that require as few internal control states as possible. In an experiment with the Abstract Decision Making task (ADM task; Joslyn & Hunt, 1998) the reward structure was manipulated to make either a low-control strategy or a high-strategy…

12 CFR 614.4255 - Independence requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... collateral supporting a loan shall subsequently participate in any decision related to the loan purchase. ... approve a loan decision on which such person performed a collateral evaluation; or (3) As a director... required to make a credit decision. (b) Officers and employees. If the institution's internal control...

75 FR 52625 - Amendment to the International Traffic in Arms Regulations: Export Exemption for Technical Data

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... the provisions of the Department of Defense National Industrial Security Program Operating Manual, an... Department of Defense National Industrial Security Program Operating Manual (unless such requirements are in..., Arms Control and International Security, Department of State. [FR Doc. 2010-21450 Filed 8-26-10; 8:45...

A sustained-arc ignition system for internal combustion engines

NASA Technical Reports Server (NTRS)

Birchenough, A. G.

1977-01-01

A sustained-arc ignition system was developed for internal combustion engines. It produces a very-long-duration ignition pulse with an energy in the order of 100 millijoules. The ignition pulse waveform can be controlled to predetermined actual ignition requirements. The design of the sustained-arc ignition system is presented in the report.

Interface Management for a NASA Flight Project Using Model-Based Systems Engineering (MBSE)

NASA Technical Reports Server (NTRS)

Vipavetz, Kevin; Shull, Thomas A.; Infeld, Samatha; Price, Jim

2016-01-01

The goal of interface management is to identify, define, control, and verify interfaces; ensure compatibility; provide an efficient system development; be on time and within budget; while meeting stakeholder requirements. This paper will present a successful seven-step approach to interface management used in several NASA flight projects. The seven-step approach using Model Based Systems Engineering will be illustrated by interface examples from the Materials International Space Station Experiment-X (MISSE-X) project. The MISSE-X was being developed as an International Space Station (ISS) external platform for space environmental studies, designed to advance the technology readiness of materials and devices critical for future space exploration. Emphasis will be given to best practices covering key areas such as interface definition, writing good interface requirements, utilizing interface working groups, developing and controlling interface documents, handling interface agreements, the use of shadow documents, the importance of interface requirement ownership, interface verification, and product transition.

International training course on nuclear materials accountability for safeguards purposes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-12-01

The two volumes of this report incorporate all lectures and presentations at the International Training Course on Nuclear Materials Accountability and Control for Safeguards Purposes, held May 27-June 6, 1980, at the Bishop's Lodge near Santa Fe, New Mexico. The course, authorized by the US Nuclear Non-Proliferation Act and sponsored by the US Department of Energy in cooperation with the International Atomic Energy Agency, was developed to provide practical training in the design, implementation, and operation of a National system of nuclear materials accountability and control that satisfies both National and IAEA International safeguards objectives. Volume I, covering the firstmore » week of the course, presents the background, requirements, and general features of material accounting and control in modern safeguard systems. Volume II, covering the second week of the course, provides more detailed information on measurement methods and instruments, practical experience at power reactor and research reactor facilities, and examples of operating state systems of accountability and control.« less

[The continuous graphic presentation of interdepartmental results (author's transl)].

PubMed

Berger, J; Hirsch, H

1976-10-01

The results of interdepartmental determinations can be clearly presented in the laboratory in two ways: 1. Entry on a test card, according to Shewhart, as used in internal quality control. 2. Entry on a test card, constructed on the principle of the Cusum test. By the latter procedure, systematic errors are detected sooner than with the usual test card. A graphic variant of the Cusum test is described; a V-mask is not required; the card superficially resembles the usual control card, and the calculation time is minimal. This method may also be used to advantage in internal quality control.

The Politics of Aviation English Testing

ERIC Educational Resources Information Center

Alderson, J. Charles

2011-01-01

The International Civil Aviation Association has developed a set of Language Proficiency Requirements (LPRs) and a Language Proficiency Rating Scale, which seeks to define proficiency in the language needed for aviation purposes at six different levels. Pilots, air traffic controllers and aeronautical station operators are required to achieve at…

12 CFR 652.35 - Liquidity reserve management and requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Liquidity reserve management and requirements... AGRICULTURAL MORTGAGE CORPORATION FUNDING AND FISCAL AFFAIRS § 652.35 Liquidity reserve management and... that management uses adequate internal controls to ensure compliance with the liquidity reserve policy...

78 FR 60099 - Nontank Vessel Response Plans and Other Response Plan Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

... Convention for the Prevention of Pollution From Ships MEPC Marine Environment Protection Committee NAICS... vessels to prepare and submit oil spill response plans. The Federal Water Pollution Control Act defines.... Additionally, this final rule updates the international Shipboard Oil Pollution Emergency Plan requirements...

22 CFR 124.12 - Required information in letters of transmittal.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... 124.12 Section 124.12 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS AGREEMENTS, OFF-SHORE PROCUREMENT AND OTHER DEFENSE SERVICES § 124.12 Required information in letters of... Defense Trade Controls. The explanatory letter shall contain: (1) A statement giving the applicant's...

Facilities for Biological Research Aboard the International Space Station

NASA Technical Reports Server (NTRS)

Souza, Kenneth A.; Yost, Bruce D.; Berry, William E.; Johnson, Catherine C.

1996-01-01

A centrifuge designed as part of an integrated biological facility for installation onboard the International Space Station is presented. The requirements for the 2.5 m diameter centrifuge, which is designed for the support of biological experiments are discussed. The scientific objectives of the facility are to: provide a means of conducting fundamental studies in which gravitational acceleration is a controllable variable; provide a 1g control; determine the threshold acceleration for physiological response, and determine the value of centrifugation as a potential countermeasure for the biomedical problems associated with space flight. The implementation of the facility is reported on, and the following aspects of the facility are described: the host resources systems supply requirements such as power and data control; the habitat holding rack; the life sciences glove box; the centrifuge; the different habitats for cell culture, aquatic studies, plant research and insect research; the egg incubator, and the laboratory support equipment.

Development of homologous viral internal controls for use in RT-PCR assays of waterborne enteric viruses.

PubMed

Parshionikar, Sandhya U; Cashdollar, Jennifer; Fout, G Shay

2004-10-01

Enteric viruses often contaminate water sources causing frequent outbreaks of gastroenteritis. Reverse transcription-polymerase chain reaction (RT-PCR) assays are commonly used for detection of human enteric viruses in environmental and drinking water samples. RT-PCR provides a means to rapidly detect low levels of these viruses, but it is sensitive to inhibitors that are present in water samples. Inhibitors of RT-PCR are concentrated along with viruses during sample processing. While procedures have been developed to remove inhibitors, none of them completely remove all inhibitors from all types of water matrices. This problem requires that adequate controls be used to distinguish true from potentially false-negative results. To address this problem, we have developed homologous viral internal controls for hepatitis A virus (HAV), poliovirus, Norwalk virus and rotavirus. These internal controls can be used in RT-PCR assays for the detection of the above viruses by competitive amplification, thereby allowing the detection of false negatives in processed water samples. The internal controls developed in this study were successfully tested with virus-seeded environmental water sample concentrates.

32 CFR Appendix A to Part 290 - DCAA's Organization and Mission

Code of Federal Regulations, 2010 CFR

2010-07-01

... established audit quality control standards, policies, and procedures and other internal control requirements... Information Service, 5285 Port Royal Road, Springfield, VA 22161. (c) Objective. Assist in achieving the... provides accounting and financial advisory service regarding contracts to all DoD components responsible...

12 CFR 37.8 - Safety and soundness requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... effective risk management and control processes over its debt cancellation contracts and debt suspension... manage the risks associated with debt cancellation contracts and debt suspension agreements in accordance... the products. A bank also should assess the adequacy of its internal control and risk mitigation...

12 CFR 48.13 - Trading and operational standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... controls required. A national bank engaging in retail forex transactions must establish and implement internal policies, procedures, and controls designed, at a minimum, to: (1) Ensure, to the extent... orders, directly or indirectly, with another person in a manner designed to circumvent the provisions of...

12 CFR 48.13 - Trading and operational standards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... controls required. A national bank engaging in retail forex transactions must establish and implement internal policies, procedures, and controls designed, at a minimum, to: (1) Ensure, to the extent... orders, directly or indirectly, with another person in a manner designed to circumvent the provisions of...

12 CFR 48.13 - Trading and operational standards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... controls required. A national bank engaging in retail forex transactions must establish and implement internal policies, procedures, and controls designed, at a minimum, to: (1) Ensure, to the extent... orders, directly or indirectly, with another person in a manner designed to circumvent the provisions of...

12 CFR 37.8 - Safety and soundness requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... effective risk management and control processes over its debt cancellation contracts and debt suspension... manage the risks associated with debt cancellation contracts and debt suspension agreements in accordance... the products. A bank also should assess the adequacy of its internal control and risk mitigation...

A comparison between electromechanical and pneumatic-controlled knee simulators for the investigation of wear of total knee replacements.

PubMed

Abdelgaied, Abdellatif; Fisher, John; Jennings, Louise M

2017-07-01

More robust preclinical experimental wear simulation methods are required in order to simulate a wider range of activities, observed in different patient populations such as younger more active patients, as well as to fully meet and be capable of going well beyond the existing requirements of the relevant international standards. A new six-station electromechanically driven simulator (Simulation Solutions, UK) with five fully independently controlled axes of articulation for each station, capable of replicating deep knee bending as well as other adverse conditions, which can be operated in either force or displacement control with improved input kinematic following, has been developed to meet these requirements. This study investigated the wear of a fixed-bearing total knee replacement using this electromechanically driven fully independent knee simulator and compared it to previous data from a predominantly pneumatically controlled simulator in which each station was not fully independently controlled. In addition, the kinematic performance and the repeatability of the simulators have been investigated and compared to the international standard requirements. The wear rates from the electromechanical and pneumatic knee simulators were not significantly different, with wear rates of 2.6 ± 0.9 and 2.7 ± 0.9 mm 3 /million cycles (MC; mean ± 95% confidence interval, p = 0.99) and 5.4 ± 1.4 and 6.7 ± 1.5 mm 3 /MC (mean ± 95 confidence interval, p = 0.54) from the electromechanical and pneumatic simulators under intermediate levels (maximum 5 mm) and high levels (maximum 10 mm) of anterior-posterior displacements, respectively. However, the output kinematic profiles of the control system, which drive the motion of the simulator, followed the input kinematic profiles more closely on the electromechanical simulator than the pneumatic simulator. In addition, the electromechanical simulator was capable of following kinematic and loading input cycles within the tolerances of the international standard requirements (ISO 14243-3). The new-generation electromechanical knee simulator with fully independent control has the potential to be used for a much wider range of kinematic conditions, including high-flexion and other severe conditions, due to its improved capability and performance in comparison to the previously used pneumatic-controlled simulators.

A comparison between electromechanical and pneumatic-controlled knee simulators for the investigation of wear of total knee replacements

PubMed Central

Abdelgaied, Abdellatif; Fisher, John; Jennings, Louise M

2017-01-01

More robust preclinical experimental wear simulation methods are required in order to simulate a wider range of activities, observed in different patient populations such as younger more active patients, as well as to fully meet and be capable of going well beyond the existing requirements of the relevant international standards. A new six-station electromechanically driven simulator (Simulation Solutions, UK) with five fully independently controlled axes of articulation for each station, capable of replicating deep knee bending as well as other adverse conditions, which can be operated in either force or displacement control with improved input kinematic following, has been developed to meet these requirements. This study investigated the wear of a fixed-bearing total knee replacement using this electromechanically driven fully independent knee simulator and compared it to previous data from a predominantly pneumatically controlled simulator in which each station was not fully independently controlled. In addition, the kinematic performance and the repeatability of the simulators have been investigated and compared to the international standard requirements. The wear rates from the electromechanical and pneumatic knee simulators were not significantly different, with wear rates of 2.6 ± 0.9 and 2.7 ± 0.9 mm3/million cycles (MC; mean ± 95% confidence interval, p = 0.99) and 5.4 ± 1.4 and 6.7 ± 1.5 mm3/MC (mean ± 95 confidence interval, p = 0.54) from the electromechanical and pneumatic simulators under intermediate levels (maximum 5 mm) and high levels (maximum 10 mm) of anterior–posterior displacements, respectively. However, the output kinematic profiles of the control system, which drive the motion of the simulator, followed the input kinematic profiles more closely on the electromechanical simulator than the pneumatic simulator. In addition, the electromechanical simulator was capable of following kinematic and loading input cycles within the tolerances of the international standard requirements (ISO 14243-3). The new-generation electromechanical knee simulator with fully independent control has the potential to be used for a much wider range of kinematic conditions, including high-flexion and other severe conditions, due to its improved capability and performance in comparison to the previously used pneumatic-controlled simulators. PMID:28661228

International Space Station (ISS) Internal Active Thermal Control System (IATCS) New Biocide Selection, Qualification and Implementation

NASA Technical Reports Server (NTRS)

Wilson, Mark E.; Cole, Harold E.; Rector, Tony; Steele, John; Varsik, Jerry

2011-01-01

The Internal Active Thermal Control System (IATCS) aboard the International Space Station (ISS) is primarily responsible for the removal of heat loads from payload and system racks. The IATCS is a water based system which works in conjunction with the EATCS (External ATCS), an ammonia based system, which are interfaced through a heat exchanger to facilitate heat transfer. On-orbit issues associated with the aqueous coolant chemistry began to occur with unexpected increases in CO2 levels in the cabin. This caused an increase in total inorganic carbon (TIC), a reduction in coolant pH, increased corrosion, and precipitation of nickel phosphate. These chemical changes were also accompanied by the growth of heterotrophic bacteria that increased risk to the system and could potentially impact crew health and safety. Studies were conducted to select a biocide to control microbial growth in the system based on requirements for disinfection at low chemical concentration (effectiveness), solubility and stability, material compatibility, low toxicity to humans, compatibility with vehicle environmental control and life support systems (ECLSS), ease of application, rapid on-orbit measurement, and removal capability. Based on these requirements, ortho-phthalaldehyde (OPA), an aromatic dialdehyde compound, was selected for qualification testing. This paper presents the OPA qualification test results, development of hardware and methodology to safely apply OPA to the system, development of a means to remove OPA, development of a rapid colorimetric test for measurement of OPA, and the OPA on-orbit performance for controlling the growth of microorganisms in the ISS IATCS since November 3, 2007.

International Space Station (ISS) Internal Active Thermal Control System (IATCS) New Biocide Selection, Qualification and Implementation

NASA Technical Reports Server (NTRS)

Wilson, Mark E.; Cole, Harold; Rector, Tony; Steele, John; Varsik, Jerry

2010-01-01

The Internal Active Thermal Control System (IATCS) aboard the International Space Station (ISS) is primarily responsible for the removal of heat loads from payload and system racks. The IATCS is a water based system which works in conjunction with the EATCS (External ATCS), an ammonia based system, which are interfaced through a heat exchanger to facilitate heat transfer. On-orbit issues associated with the aqueous coolant chemistry began to occur with unexpected increases in CO2 levels in the cabin. This caused an increase in total inorganic carbon (TIC), a reduction in coolant pH, increased corrosion, and precipitation of nickel phosphate. These chemical changes were also accompanied by the growth of heterotrophic bacteria that increased risk to the system and could potentially impact crew health and safety. Studies were conducted to select a biocide to control microbial growth in the system based on requirements for disinfection at low chemical concentration (effectiveness), solubility and stability, material compatibility, low toxicity to humans, compatibility with vehicle environmental control and life support systems (ECLSS), ease of application, rapid on-orbit measurement, and removal capability. Based on these requirements, ortho-phthalaldehyde (OPA), an aromatic dialdehyde compound, was selected for qualification testing. This paper presents the OPA qualification test results, development of hardware and methodology to safely apply OPA to the system, development of a means to remove OPA, development of a rapid colorimetric test for measurement of OPA, and the OPA on-orbit performance for controlling the growth of microorganisms in the ISS IATCS since November 3, 2007.

Academic Relationships and Teaching Resources. Fogarty International Center Series on the Teaching of Preventive Medicine, Volume 6.

ERIC Educational Resources Information Center

Clark, Duncan W., Ed.

The monograph is one of the Fogarty International Center Series on the Teaching of Preventive Medicine, undertaken to: (1) review and evaluate the state of the art of prevention and control of human diseases; (2) identify deficiences in knowledge requiring further research (including analysis of financial resources, preventive techniques, and…

12 CFR Appendix B to Part 741 - Guidance for an Interest Rate Risk Policy and an Effective Program

Code of Federal Regulations, 2013 CFR

2013-01-01

... Measurement Methods C. Components of IRR Measurement Methods V. Internal Controls VI. Decision-Making Informed... effective IRR management program identifies, measures, monitors, and controls IRR and is central to safe and... critical to the control of IRR exposure. All FICUs required to have an IRR policy and program should...

12 CFR Appendix B to Part 741 - Guidance for an Interest Rate Risk Policy and an Effective Program

Code of Federal Regulations, 2014 CFR

2014-01-01

... Measurement Methods C. Components of IRR Measurement Methods V. Internal Controls VI. Decision-Making Informed... effective IRR management program identifies, measures, monitors, and controls IRR and is central to safe and... critical to the control of IRR exposure. All FICUs required to have an IRR policy and program should...

Analysis of Decision Factors for the Application of Information Access Controls within the Organization

ERIC Educational Resources Information Center

Foerster, Carl A.

2013-01-01

The application of access controls on internal information necessarily impacts the availability of that information for sharing inside the enterprise. The decisions establishing the degree of control are a crucial first step to balance the requirements to protect and share. This research develops a set of basic decision factors and examines other…

12 CFR 349.13 - Trading and operational standards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... controls designed, at a minimum, to: (1) Ensure, to the extent reasonable, that each order received from a...) Internal rules, procedures, and controls required. An FDIC-supervised insured depository institution... related persons from placing orders, directly or indirectly, with another person in a manner designed to...

12 CFR 349.13 - Trading and operational standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... controls designed, at a minimum, to: (1) Ensure, to the extent reasonable, that each order received from a...) Internal rules, procedures, and controls required. An FDIC-supervised insured depository institution... related persons from placing orders, directly or indirectly, with another person in a manner designed to...

12 CFR 349.13 - Trading and operational standards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... controls designed, at a minimum, to: (1) Ensure, to the extent reasonable, that each order received from a...) Internal rules, procedures, and controls required. An FDIC-supervised insured depository institution... related persons from placing orders, directly or indirectly, with another person in a manner designed to...

RCT: Module 2.07, Respiratory Protection, Course 8773

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hillmer, Kurt T.

Internal dosimetry controls require the use of engineering controls to prevent the internal deposition of radioactive and nonradiological contaminants. However, when engineering and administrative controls are not available or feasible, respiratory protection may be necessary. The radiation control technician (RCT) should know and apply the considerations used in determining the respiratory protection equipment that is most appropriate for the job. The inappropriate use of or the use of the wrong respiratory protection equipment may result in undesirable health effects. This course will prepare the student with the skills necessary for RCT qualification by passing quizzes, tests, and the RCT Comprehensivemore » Phase 1, Unit 2 Examination (TEST 27566) and will provide in-the-field skills.« less

Nonlinear dynamics of mini-satellite respinup by weak internal controllable torques

NASA Astrophysics Data System (ADS)

Somov, Yevgeny

2014-12-01

Contemporary space engineering advanced new problem before theoretical mechanics and motion control theory: a spacecraft directed respinup by the weak restricted control internal forces. The paper presents some results on this problem, which is very actual for energy supply of information mini-satellites (for communication, geodesy, radio- and opto-electronic observation of the Earth et al.) with electro-reaction plasma thrusters and gyro moment cluster based on the reaction wheels or the control moment gyros. The solution achieved is based on the methods for synthesis of nonlinear robust control and on rigorous analytical proof for the required spacecraft rotation stability by Lyapunov function method. These results were verified by a computer simulation of strongly nonlinear oscillatory processes at respinuping of a flexible spacecraft.

Educational interventions to improve knowledge and skills of interns towards prevention and control of hospital-associated infections.

PubMed

Dogra, Sandeep; Mahajan, Ruchita; Jad, Beena; Mahajan, Bella

2015-08-01

We believe that there is significant educational deficit amongst interns regarding up-to-date formal knowledge and skills on healthcare-associated infections (HAIs) which might compromise patient safety. This urgently requires curriculum innovations to ensure their formal training on HAIs prevention and control. Education of interns to improve their knowledge and skills toward HAIs prevention and control. This pilot study was conducted in interns using a multimodal approach consisting of a combination of videos, PowerPoint presentation, and hands-on demonstration to provide applied and practical teaching on prevention and control of HAIs. Pre- and post-test assessment of knowledge, attitude, and skills was carried out by multiple choice questions, 5-point Likert scale, and Objective Structured Practical Examination respectively. Paired t-test. A statistically significant improvement in the overall score rates between pre- and post-test of intern's was seen, suggesting that educational programs have a positive effect. Intern's felt benefitted from interventions focused on HAIs prevention and control and hoped that such sessions are integrated in the regular undergraduate curriculum. A majority of the students felt that their learning style assessment matched well with their own perception of learning preference. Assessment drives learning; hence strengthening the contribution of health-care workers to HAIs prevention programs should include measures that enhance knowledge, improve skills and develop appropriate attitudes, resulting in safety and quality of patient care.

Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins*

PubMed Central

Smith, Thomas H.; Coronel, Luisa J.; Li, Julia G.; Dores, Michael R.; Nieman, Marvin T.; Trejo, JoAnn

2016-01-01

Protease-activated receptor-4 (PAR4) is a G protein-coupled receptor (GPCR) for thrombin and is proteolytically activated, similar to the prototypical PAR1. Due to the irreversible activation of PAR1, receptor trafficking is intimately linked to signal regulation. However, unlike PAR1, the mechanisms that control PAR4 trafficking are not known. Here, we sought to define the mechanisms that control PAR4 trafficking and signaling. In HeLa cells depleted of clathrin by siRNA, activated PAR4 failed to internalize. Consistent with clathrin-mediated endocytosis, expression of a dynamin dominant-negative K44A mutant also blocked activated PAR4 internalization. However, unlike most GPCRs, PAR4 internalization occurred independently of β-arrestins and the receptor's C-tail domain. Rather, we discovered a highly conserved tyrosine-based motif in the third intracellular loop of PAR4 and found that the clathrin adaptor protein complex-2 (AP-2) is important for internalization. Depletion of AP-2 inhibited PAR4 internalization induced by agonist. In addition, mutation of the critical residues of the tyrosine-based motif disrupted agonist-induced PAR4 internalization. Using Dami megakaryocytic cells, we confirmed that AP-2 is required for agonist-induced internalization of endogenous PAR4. Moreover, inhibition of activated PAR4 internalization enhanced ERK1/2 signaling, whereas Akt signaling was markedly diminished. These findings indicate that activated PAR4 internalization requires AP-2 and a tyrosine-based motif and occurs independent of β-arrestins, unlike most classical GPCRs. Moreover, these findings are the first to show that internalization of activated PAR4 is linked to proper ERK1/2 and Akt activation. PMID:27402844

10 CFR 1706.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Definitions. 1706.2 Section 1706.2 Energy DEFENSE NUCLEAR... with respect to its internal functions or its oversight of defense nuclear facilities, or otherwise to... party controls or can control both. Board means, as the context requires, the Defense Nuclear Facilities...

10 CFR 1706.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Definitions. 1706.2 Section 1706.2 Energy DEFENSE NUCLEAR... with respect to its internal functions or its oversight of defense nuclear facilities, or otherwise to... party controls or can control both. Board means, as the context requires, the Defense Nuclear Facilities...

10 CFR 1706.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Definitions. 1706.2 Section 1706.2 Energy DEFENSE NUCLEAR... with respect to its internal functions or its oversight of defense nuclear facilities, or otherwise to... party controls or can control both. Board means, as the context requires, the Defense Nuclear Facilities...

25 CFR 543.16 - What are the minimum internal controls for information technology?

Code of Federal Regulations, 2010 CFR

2010-04-01

... technology? 543.16 Section 543.16 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN... controls for information technology? (a) Physical security measures restricting access to agents, including... longer required. (2) In the event of remote access, the information technology employees must prepare a...

Role of the international organisation for animal health (Office International des Epizooties: OIE) in the control of foot and mouth disease.

PubMed

Vallat, B

2002-10-01

The author describes activities conducted by the International Organisation for Animal Health (OIE: Office International des Epizooties) to control foot and mouth disease (FMD) world-wide. These activities fall within the framework of the principal missions of the OIE. The first of these missions is the collection and dissemination of epidemiological information and of scientific knowledge on animal diseases, the socio-economic or disease implications of which can be particularly serious. The implementation of the measures required to control the disease and to protect countries threatened by FMD depends on the quality and rapidity of the transmission of this information. The co-ordination of studies, research and control programmes against FMD is equally important for the OIE. This work is based, in particular, on work conducted by the OlE foot and mouth disease and other epizootics Commission. OIE Member Countries not only have access to the most recent data on the diagnosis, surveillance and control of FMD but also have recourse to the official recognition procedure for disease-free status provided by this Commission. Finally, through the standardisation of health recommendations, diagnostic tests, manufacture protocols and the control of biological products, made available by the OIE International Animal Health Code Commission in regard to the former and by the OIE Standards Commission in regard to the latter, the OIE provides the reference for international trade in animals and animal products, and is recognised in this role by the World Trade Organization.

International Space Station External Contamination Status

NASA Technical Reports Server (NTRS)

Mikatarian, Ron; Soares, Carlos

2000-01-01

PResentation slides examine external contamination requirements; International Space Station (ISS) external contamination sources; ISS external contamination sensitive surfaces; external contamination control; external contamination control for pre-launch verification; flight experiments and observations; the Space Shuttle Orbiter waste water dump, materials outgassing, active vacuum vents; example of molecular column density profile, modeling and analysis tools; sources of outgassing induced contamination analyzed to date, quiescent sources, observations on optical degradation due to induced external contamination in LEO; examples of typical contaminant and depth profiles; and status of the ISS system, material outgassing, thruster plumes, and optical degradation.

Update on antimicrobial resistance.

PubMed

Weber, Carol J

2005-02-01

WHO experts believe that antimicrobial resistance is potentially containable, but the window of opportunity to control and eventually eliminate the most dangerous infectious diseases is closing. If we miss our opportunity, it may become very difficult and expensive--and in some cases impossible--to treat infectious diseases. WHO's global strategy to contain antimicrobial resistance requires a massive effort and an alliance among countries, governments, international organizations, drug manufacturers, and private and public health care sectors. If infectious diseases are fought wisely and widely by the international community, drug resistance can be controlled and lives saved.

40 CFR 63.771 - Control equipment requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... includes openings necessary to equalize or balance the internal pressure of the unit following changes in... flame zone of the boiler or process heater. (ii) A vapor recovery device (e.g., carbon adsorption system... demonstrate compliance according to the requirements of § 63.772(f) or (g), as applicable. (5) For each carbon...

40 CFR 63.771 - Control equipment requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... includes openings necessary to equalize or balance the internal pressure of the unit following changes in... flame zone of the boiler or process heater. (ii) A vapor recovery device (e.g., carbon adsorption system... demonstrate compliance according to the requirements of § 63.772(f) or (g), as applicable. (5) For each carbon...

7 CFR 1773.32 - Report on compliance and on internal control over financial reporting.

Code of Federal Regulations, 2011 CFR

2011-01-01

... reporting. As required by GAGAS, the CPA must prepare a written report describing the auditors testing of... reporting and present the results of those tests. This report must be signed by the CPA and must include, as a minimum: (a) The scope of the CPA's testing of compliance with laws and regulations and internal...

7 CFR 1773.32 - Report on compliance and on internal control over financial reporting.

Code of Federal Regulations, 2014 CFR

2014-01-01

... reporting. As required by GAGAS, the CPA must prepare a written report describing the auditors testing of... reporting and present the results of those tests. This report must be signed by the CPA and must include, as a minimum: (a) The scope of the CPA's testing of compliance with laws and regulations and internal...

7 CFR 1773.32 - Report on compliance and on internal control over financial reporting.

Code of Federal Regulations, 2013 CFR

2013-01-01

... reporting. As required by GAGAS, the CPA must prepare a written report describing the auditors testing of... reporting and present the results of those tests. This report must be signed by the CPA and must include, as a minimum: (a) The scope of the CPA's testing of compliance with laws and regulations and internal...

7 CFR 1773.32 - Report on compliance and on internal control over financial reporting.

Code of Federal Regulations, 2012 CFR

2012-01-01

... reporting. As required by GAGAS, the CPA must prepare a written report describing the auditors testing of... reporting and present the results of those tests. This report must be signed by the CPA and must include, as a minimum: (a) The scope of the CPA's testing of compliance with laws and regulations and internal...

[Implementation of the technical requirements of the UNE-EN-ISO 15189 quality standard in a mycobacterial laboratory].

PubMed

Guna Serrano, M del Remedio; Ocete Mochón, M Dolores; Lahiguera, M José; Bresó, M Carmen; Gimeno Cardona, Concepción

2013-02-01

The UNE-EN-ISO 15189:2007 standard defines the requirements for quality and competence that must be met by medical laboratories. These laboratories should use this international standard to develop their own quality management systems and to evaluate their own competencies; in turn, this standard will be used by accreditation bodies to confirm or recognize the laboratories' competence. In clinical microbiology laboratories, application of the standard implies the implementation of the technical and specific management requirements that must be met to achieve optimal quality when carrying out microbiological tests. In Spain, accreditation is granted by the Spanish Accreditation Body (Entidad Nacional de Acreditación). This review aims to discuss the practical application of the standard's technical requirements in mycobacterial laboratory. Firstly, we define the scope of accreditation. Secondly, we specify how the items of the standard on personnel management, control of equipment, environmental facilities, method validation, internal controls and customer satisfaction surveys were developed and implemented in our laboratory. Copyright © 2013 Elsevier España, S.L. All rights reserved.

Fluxes of Ca2+ and K+ are required for the listeriolysin O-dependent internalization pathway of Listeria monocytogenes.

PubMed

Vadia, Stephen; Seveau, Stephanie

2014-03-01

Listeria monocytogenes is responsible for the life-threatening food-borne disease listeriosis. This disease mainly affects elderly and immunocompromised individuals, causing bacteremia and meningoencephalitis. In pregnant women, L. monocytogenes infection leads to abortion and severe infection of the fetus or newborn. The L. monocytogenes intracellular life cycle is critical for pathogenesis. Previous studies have established that the major virulence factor of L. monocytogenes, the pore-forming toxin listeriolysin O (LLO), is sufficient to induce L. monocytogenes internalization into human epithelial cell lines. This internalization pathway strictly requires the formation of LLO pores in the plasma membrane and can be stimulated by the heterologous pore-forming toxin pneumolysin, suggesting that LLO acts nonspecifically by forming transmembrane pores. The present work tested the hypothesis that Ca2+ and K+ fluxes subsequent to perforation by LLO control L. monocytogenes internalization. We report that L. monocytogenes perforates the host cell plasma membrane in an LLO-dependent fashion at the early stage of invasion. In response to perforation, host cells undergo Ca2+ -dependent but K+ -independent resealing of their plasma membrane. In contrast to the plasma membrane resealing process, LLO-induced L. monocytogenes internalization requires both Ca2+ and K+ fluxes. Further linking ion fluxes to bacterial internalization, treating cells with a combination of Ca2+ and K+ ionophores but not with individual ionophores is sufficient to induce efficient internalization of large cargoes, such as 1-μm polystyrene beads and bacteria. We propose that LLO-induced L. monocytogenes internalization requires a Ca2+ - and K+ -dependent internalization pathway that is mechanistically distinct from the process of plasma membrane resealing.

49 CFR 192.451 - Scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.451 Scope. (a..., internal, and atmospheric corrosion. (b) [Reserved] [Amdt. 192-4, 36 FR 12302, June 30, 1971, as amended by...

49 CFR 192.451 - Scope.

Code of Federal Regulations, 2014 CFR

2014-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.451 Scope. (a..., internal, and atmospheric corrosion. (b) [Reserved] [Amdt. 192-4, 36 FR 12302, June 30, 1971, as amended by...

49 CFR 192.451 - Scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.451 Scope. (a..., internal, and atmospheric corrosion. (b) [Reserved] [Amdt. 192-4, 36 FR 12302, June 30, 1971, as amended by...

49 CFR 192.451 - Scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.451 Scope. (a..., internal, and atmospheric corrosion. (b) [Reserved] [Amdt. 192-4, 36 FR 12302, June 30, 1971, as amended by...

Pointing control for the International Comet Mission

NASA Technical Reports Server (NTRS)

Leblanc, D. R.; Schumacher, L. L.

1980-01-01

The design of the pointing control system for the proposed International Comet Mission, intended to fly by Comet Halley and rendezvous with Comet Tempel-2 is presented. Following a review of mission objectives and the spacecraft configuration, design constraints on the pointing control system controlling the two-axis gimballed scan platform supporting the science instruments are discussed in relation to the scientific requirements of the mission. The primary design options considered for the pointing control system design for the baseline spacecraft are summarized, and the design selected, which employs a target-referenced, inertially stabilized control system, is described in detail. The four basic modes of operation of the pointing control subsystem (target acquisition, inertial hold, target track and slew) are discussed as they relate to operations at Halley and Tempel-2. It is pointed that the pointing control system design represents a significant advance in the state of the art of pointing controls for planetary missions.

Beyond the permissibility of embryonic and stem cell research: substantive requirements and procedural safeguards.

PubMed

Isasi, Rosario M; Knoppers, Bartha M

2006-10-01

This report provides a comparative analysis of the regulation of embryonic stem cells and cloning research in 50 countries. The development of international stem cell consortia involving the exchange of materials, data and knowledge presumes 'policy know-how' on the varying positions and governing regulations of the various partners; knowledge is essential for the feasibility of such international collaborative projects. Across the spectrum of restrictive-to-liberal policies, requirements regarding the justification for or the setting of substantive limits on (i) embryo use and/or (ii) destruction in research are often present. These goals justify the regulation, the control and even the prohibition of embryonic stem cell and cloning research. Moreover, irrespective of whether a country adopts a restrictive or a liberal approach, there is significant symmetry in both the substantive and the procedural requirements. Procedural safeguards provide another layer of protection and control over the research. In reality, such safeguards may have a greater systemic impact than the substantive requirements. They can be subdivided into three broad categories: (i) safeguards relating to the stage of embryonic development, (ii) safeguards relating to the donors of blastocysts, gametes, embryos and somatic cells and (iii) requirements for research governance.

Technical Aspects of Acoustical Engineering for the ISS [International Space Station

NASA Technical Reports Server (NTRS)

Allen, Christopher S.

2009-01-01

It is important to control acoustic levels on manned space flight vehicles and habitats to protect crew-hearing, allow for voice communications, and to ensure a healthy and habitable environment in which to work and live. For the International Space Station (ISS) this is critical because of the long duration crew-stays of approximately 6-months. NASA and the JSC Acoustics Office set acoustic requirements that must be met for hardware to be certified for flight. Modules must meet the NC-50 requirement and other component hardware are given smaller allocations to meet. In order to meet these requirements many aspects of noise generation and control must be considered. This presentation has been developed to give an insight into the various technical activities performed at JSC to ensure that a suitable acoustic environment is provided for the ISS crew. Examples discussed include fan noise, acoustic flight material development, on-orbit acoustic monitoring, and a specific hardware development and acoustical design case, the ISS Crew Quarters.

Report on Quality Control Review of the Raich Ende Malter & Co. LLP FY 2009 Single Audit of the Riverside Research Institute

DTIC Science & Technology

2012-03-07

compliance was based on a determination that 10 of the 14 compliance requirements were applicable to the Institute. However, the audit working papers...for all 14 of the compliance requirements were not adequate to support conclusions on applicability, internal control, and the audit opinion on...compliance with laws, regulations, and award provisions applicable to the R&D cluster program. In addition, the audit firm did not appropriately report an

7 CFR 1773.30 - General.

Code of Federal Regulations, 2014 CFR

2014-01-01

... (CONTINUED) POLICY ON AUDITS OF RUS BORROWERS RUS Reporting Requirements § 1773.30 General. (a) The CPA must... letter. (b) The CPA should deliver the auditor's report, report on compliance and on internal control...

7 CFR 1773.30 - General.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (CONTINUED) POLICY ON AUDITS OF RUS BORROWERS RUS Reporting Requirements § 1773.30 General. (a) The CPA must... letter. (b) The CPA should deliver the auditor's report, report on compliance and on internal control...

7 CFR 1773.30 - General.

Code of Federal Regulations, 2012 CFR

2012-01-01

... (CONTINUED) POLICY ON AUDITS OF RUS BORROWERS RUS Reporting Requirements § 1773.30 General. (a) The CPA must... letter. (b) The CPA should deliver the auditor's report, report on compliance and on internal control...

7 CFR 1773.30 - General.

Code of Federal Regulations, 2013 CFR

2013-01-01

... (CONTINUED) POLICY ON AUDITS OF RUS BORROWERS RUS Reporting Requirements § 1773.30 General. (a) The CPA must... letter. (b) The CPA should deliver the auditor's report, report on compliance and on internal control...

Assessment of the iodine concentration in table salt at the production stage in South Africa.

PubMed Central

Jooste, Pieter L.

2003-01-01

OBJECTIVE: To determine the iodine content of iodized salt at the production stage, to assess the perceptions and knowledge of salt producers about the prevention and control of iodine deficiency, and to examine the internal quality control procedures used during iodization in South Africa. METHOD: Salt samples were collected for iodine analysis by titration from the 12 producers iodizing salt in South Africa. Information on the producers' knowledge of iodine deficiency disorders and on internal quality control was obtained by means of questionnaires. FINDINGS: The legal requirement of 40-60 ppm iodine was met in 30.9% of salt samples; 57.9% contained more than 30 ppm iodine; 34.8% contained under 20 ppm iodine. There were shortcomings in perceptions and knowledge about iodine deficiency disorders and in the internal quality control procedures of a substantial proportion of the producers. CONCLUSION: In order to encourage and support salt producers to achieve optimal iodization there should be an information, education and communication strategy aimed at improving knowledge of iodine deficiency disorders and at raising the standard of internal quality control procedures. External monitoring should continue. PMID:12973644

Nonlinear dynamics of mini-satellite respinup by weak internal controllable torques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Somov, Yevgeny, E-mail: e-somov@mail.ru

Contemporary space engineering advanced new problem before theoretical mechanics and motion control theory: a spacecraft directed respinup by the weak restricted control internal forces. The paper presents some results on this problem, which is very actual for energy supply of information mini-satellites (for communication, geodesy, radio- and opto-electronic observation of the Earth et al.) with electro-reaction plasma thrusters and gyro moment cluster based on the reaction wheels or the control moment gyros. The solution achieved is based on the methods for synthesis of nonlinear robust control and on rigorous analytical proof for the required spacecraft rotation stability by Lyapunov functionmore » method. These results were verified by a computer simulation of strongly nonlinear oscillatory processes at respinuping of a flexible spacecraft.« less

Internal Model-Based Robust Tracking Control Design for the MEMS Electromagnetic Micromirror.

PubMed

Tan, Jiazheng; Sun, Weijie; Yeow, John T W

2017-05-26

The micromirror based on micro-electro-mechanical systems (MEMS) technology is widely employed in different areas, such as scanning, imaging and optical switching. This paper studies the MEMS electromagnetic micromirror for scanning or imaging application. In these application scenarios, the micromirror is required to track the command sinusoidal signal, which can be converted to an output regulation problem theoretically. In this paper, based on the internal model principle, the output regulation problem is solved by designing a robust controller that is able to force the micromirror to track the command signal accurately. The proposed controller relies little on the accuracy of the model. Further, the proposed controller is implemented, and its effectiveness is examined by experiments. The experimental results demonstrate that the performance of the proposed controller is satisfying.

Internal Model-Based Robust Tracking Control Design for the MEMS Electromagnetic Micromirror

PubMed Central

Tan, Jiazheng; Sun, Weijie; Yeow, John T. W.

2017-01-01

The micromirror based on micro-electro-mechanical systems (MEMS) technology is widely employed in different areas, such as scanning, imaging and optical switching. This paper studies the MEMS electromagnetic micromirror for scanning or imaging application. In these application scenarios, the micromirror is required to track the command sinusoidal signal, which can be converted to an output regulation problem theoretically. In this paper, based on the internal model principle, the output regulation problem is solved by designing a robust controller that is able to force the micromirror to track the command signal accurately. The proposed controller relies little on the accuracy of the model. Further, the proposed controller is implemented, and its effectiveness is examined by experiments. The experimental results demonstrate that the performance of the proposed controller is satisfying. PMID:28587105

Control of atomic transition rates via laser-light shaping

NASA Astrophysics Data System (ADS)

Jáuregui, R.

2015-04-01

A modular systematic analysis of the feasibility of modifying atomic transition rates by tailoring the electromagnetic field of an external coherent light source is presented. The formalism considers both the center of mass and internal degrees of freedom of the atom, and all properties of the field: frequency, angular spectrum, and polarization. General features of recoil effects for internal forbidden transitions are discussed. A comparative analysis of different structured light sources is explicitly worked out. It includes spherical waves, Gaussian beams, Laguerre-Gaussian beams, and propagation invariant beams with closed analytical expressions. It is shown that increments in the order of magnitude of the transition rates for Gaussian and Laguerre-Gaussian beams, with respect to those obtained in the paraxial limit, require waists of the order of the wavelength, while propagation invariant modes may considerably enhance transition rates under more favorable conditions. For transitions that can be naturally described as modifications of the atomic angular momentum, this enhancement is maximal (within propagation invariant beams) for Bessel modes, Mathieu modes can be used to entangle the internal and center-of-mass involved states, and Weber beams suppress this kind of transition unless they have a significant component of odd modes. However, if a recoil effect of the transition with an adequate symmetry is allowed, the global transition rate (center of mass and internal motion) can also be enhanced using Weber modes. The global analysis presented reinforces the idea that a better control of the transitions between internal atomic states requires both a proper control of the available states of the atomic center of mass, and shaping of the background electromagnetic field.

17 CFR 1.17 - Minimum financial requirements for futures commission merchants and introducing brokers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... internal risk management control system of the futures commission merchant; a description of how the... section; and (ii)(A) The readily marketable collateral is in the possession or control of the applicant or... accepted accounting principles. For the purposes of computing “net capital”, the term “liabilities”: (i...

Control Requirements to Support Manual Piloting Capability

NASA Technical Reports Server (NTRS)

Merancy, Nujoud; Chevray, Kay; Gonzalez, Rodolfo; Madsen, Jennifer; Spehar, Pete

2013-01-01

The manual piloting requirements specified under the NASA Constellation Program involved Cooper-Harper ratings, which are a qualitative and subjective evaluation from experienced pilots. This type of verification entails a significant investment of resources to assess a completed design and is not one that can easily or meaningfully be applied upfront in the design phase. The evolution of the Multi-Purpose Crew Vehicle Program to include an independently developed propulsion system from an international partner makes application of Cooper-Harper based design requirements inadequate. To mitigate this issue, a novel solution was developed to reformulate the necessary piloting capability into quantifiable requirements. A trio of requirements was designed which specify control authority, precision, and impulse residuals enabling propulsion design within specified guidance and control boundaries. These requirements have been evaluated against both the existing Orion design and the proposed ESA design and have been found to achieve the desired specificity. The requirement set is capable of being applied to the development of other spacecraft in support of manual piloting.

Spacecraft stability and control

NASA Technical Reports Server (NTRS)

Barret, Chris

1992-01-01

The Earth's first artificial satellite, Sputnik 1, slowly tumbled in orbit. The first U.S. satellite, Explorer 1, also tumbled out of control. Today, satellite stability and control has become a higher priority. For a satellite design that is to have a life expectancy of 14 years, appropriate spacecraft flight control systems will be reviewed, stability requirements investigated, and an appropriate flight control system recommended in order to see the design process. Disturbance torques, including aerodynamic, magnetic, gravity gradient, solar, micrometeorite, debris, collision, and internal torques, will be assessed to quantify the disturbance environment so that the required compensating torques can be determined. The control torques, including passive versus active, momentum control, bias momentum, spin stabilization, dual spin, gravity gradient, magnetic, reaction wheels, control moment gyros, inertia augmentation techniques, three-axis control, and reaction control systems (RCSs), will be considered. Conditions for stability will also be considered.

26 CFR 1.6038-3 - Information returns required of certain United States persons with respect to controlled foreign...

Code of Federal Regulations, 2010 CFR

2010-04-01

... relating to such interests during that tax year. (6) Definition of United States person. The term United... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Information Returns § 1.6038-3 Information returns required of certain United States persons with...

Minimal algorithm for running an internal combustion engine

NASA Astrophysics Data System (ADS)

Stoica, V.; Borborean, A.; Ciocan, A.; Manciu, C.

2018-01-01

The internal combustion engine control is a well-known topic within automotive industry and is widely used. However, in research laboratories and universities the use of a control system trading is not the best solution because of predetermined operating algorithms, and calibrations (accessible only by the manufacturer) without allowing massive intervention from outside. Laboratory solutions on the market are very expensive. Consequently, in the paper we present a minimal algorithm required to start-up and run an internal combustion engine. The presented solution can be adapted to function on performance microcontrollers available on the market at the present time and at an affordable price. The presented algorithm was implemented in LabView and runs on a CompactRIO hardware platform.

Respirators, internal dose, and Oyster Creek

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michal, R.

1996-06-01

This article looks at the experience of Oyster Creek in relaxing the requirements for the use of respirators in all facets of plant maintenance, on the overall dose received by plant maintenance personnel. For Roger Shaw, director of radiological controls for three years at GPU Nuclear Corporation`s Oyster Creek nuclear plant the correct dose balance is determined on a job-by-job basis: Does the job require a respirator, which is an effective means of decreasing worker inhalation of airborne radioactive particles? Will wearing a respirator slow down a worker, consequently increasing whole body radiation exposure by prolonging the time spent inmore » fields of high external radiation? How does respiratory protection affect worker safety and to what degree? While changes to the Nuclear Regulatory Commission`s 10CFR20 have updated the radiation protection requirements for the nuclear industry, certain of the revisions have been directed specifically at reducing worker dose, Shaw said. {open_quotes}It basically delineates that dose is dose,{close_quotes} Shaw said, {open_quotes}regardless of whether it is acquired externally or internally.{close_quotes} The revision of Part 20 changed the industry`s attitude toward internal dose, which had always been viewed negatively. {open_quotes}Internal dose was always seen as preventable by wearing respirators and by using engineering techniques such as ventilation control and decontamination,{close_quotes} Shaw said, {open_quotes}whereas external dose, although reduced where practical, was seen as a fact of the job.{close_quotes}« less

Generator voltage stabilisation for series-hybrid electric vehicles.

PubMed

Stewart, P; Gladwin, D; Stewart, J; Cowley, R

2008-04-01

This paper presents a controller for use in speed control of an internal combustion engine for series-hybrid electric vehicle applications. Particular reference is made to the stability of the rectified DC link voltage under load disturbance. In the system under consideration, the primary power source is a four-cylinder normally aspirated gasoline internal combustion engine, which is mechanically coupled to a three-phase permanent magnet AC generator. The generated AC voltage is subsequently rectified to supply a lead-acid battery, and permanent magnet traction motors via three-phase full bridge power electronic inverters. Two complementary performance objectives exist. Firstly to maintain the internal combustion engine at its optimal operating point, and secondly to supply a stable 42 V supply to the traction drive inverters. Achievement of these goals minimises the transient energy storage requirements at the DC link, with a consequent reduction in both weight and cost. These objectives imply constant velocity operation of the internal combustion engine under external load disturbances and changes in both operating conditions and vehicle speed set-points. An electronically operated throttle allows closed loop engine velocity control. System time delays and nonlinearities render closed loop control design extremely problematic. A model-based controller is designed and shown to be effective in controlling the DC link voltage, resulting in the well-conditioned operation of the hybrid vehicle.

A comparative study of RNA and DNA as internal gene expression controls early in the developmental cycle of Chlamydia pneumoniae.

PubMed

Engström, Patrik; Bailey, Leslie; Onskog, Thomas; Bergström, Sven; Johansson, Jörgen

2010-03-01

Many microbial pathogens invade and proliferate within host cells and the molecular mechanism underlying this behavior is currently being revealed for several bacterial species. Testing clinically relevant antibacterial compounds and elucidating their effects on gene expression requires adequate controls, especially when studying genetically intractable organisms such as Chlamydia spp., for which various gene fusions cannot be constructed. Until now, relative mRNA levels in Chlamydia have been measured using different internal gene expression controls, including 16S rRNA, mRNAs, and DNA. Here, we compared the advantages and disadvantages of various internal expression controls during the early phase of Chlamydia pneumoniae development. The relative abundance of target mRNAs varied using the different internal control RNAs. This was partly due to variation in the transcript stability of the RNA species. Also, seven out of nine of the analyzed RNAs increased fivefold or more between 2 and 14 h postinfection, while the amount of DNA and number of cells remained essentially unaltered. Our results suggest that RNA should not be used as a gene expression control during the early phase of Chlamydia development, and that intrinsic bacterial DNA is preferable for that purpose because it is stable, abundant, and its relative amount is generally correlated with bacterial numbers.

Improvement of vertical stabilization on KSTAR

NASA Astrophysics Data System (ADS)

Mueller, D.; Bak, J. G.; Boyer, M. D.; Eideitis, N.; Hahn, S. H.; Humphreys, D. A.; Kim, H. S.; Jeon, Y. M.; Lanctot, M.; Walker, M. L.

2017-10-01

The successful control of strongly shaped plasmas on the Korea Superconducting Tokamak Advanced Research (KSTAR) device requires active feedback of fast motion of the plasma vertical position by the use of internal normal conducting coils (IVC). This has required new electronics to supply relative flux loop differences, for zp, and voltage loop differences, for dzp/dt, as well as a novel technique (Zfast) to use a high-pass filter, typically 1 Hz, on the error in the signal in the feedback loop. Use of Zfast avoids the potential contention encountered when the internal coil attempts to perform control of the plasma shape which should be controlled by the slower and more powerful superconducting coils. A common problem of this contention is saturation of the IVC and loss of fast vertical control. This is eliminated by proper use of the Zfast. A Ziegler-Nichols relay feedback system was used to fine tune the required feedback gains. The selection of the magnetic sensors, filter time constants, control gains and of the Zfast control strategy which allowed vertically stable operation at a plasma elongation, kappa. of up to 2.16 at li = 1.15 and Betap = 2.4 will be discussed which is beyond the design reference of KSTAR of kappa = 2.0 at li = 1.2 and Betap = 1.9. Work Supported by U.S.D.O.E. Contract No. DE-AC02-09CH11466 and DE-SC0010685 and the KSTAR project.

Assuring fish safety and quality in international fish trade.

PubMed

Ababouch, Lahsen

2006-01-01

International trade in fishery commodities reached US 58.2 billion dollars in 2002, a 5% improvement relative to 2000 and a 45% increase over 1992 levels. Within this global trade, developing countries registered a net trade surplus of US 17.4 billion dollars in 2002 and accounted for almost 50% by value and 55% of fish exports by volume. This globalization of fish trade, coupled with technological developments in food production, handling, processing and distribution, and the increasing awareness and demand of consumers for safe and high quality food have put food safety and quality assurance high in public awareness and a priority for many governments. Consequently, many countries have tightened food safety controls, imposing additional costs and requirements on imports. As early as 1980, there was an international drive towards adopting preventative HACCP-based safety and quality systems. More recently, there has been a growing awareness of the importance of an integrated, multidisciplinary approach to food safety and quality throughout the entire food chain. Implementation of this approach requires an enabling policy and regulatory environment at national and international levels with clearly defined rules and standards, establishment of appropriate food control systems and programmes at national and local levels, and provision of appropriate training and capacity building. This paper discusses the international framework for fish safety and quality, with particular emphasis on the United Nation's Food and Agricultural Organization's (FAO) strategy to promote international harmonization and capacity building.

Availability of health data: requirements and solutions.

PubMed

Espinosa, A L

1998-03-01

There is an increasing recognition of the importance of the health data available for the corporate healthcare system model with the electronic patient record as the central unit of the healthcare information systems. There is also increasing recognition of the importance of developing simple international standards for record components, including clinical and administrative requirements. Aspects of security and confidentiality have to be reviewed in detail. The advantages of having health data available when and where it is required will modify healthcare delivery and support cost control with economies of scale and sharing of resources. The infrastructure necessary to make this model a reality is being developed through different international initiatives, which have to be integrated and co-ordinated to have common disaster planning strategies and better funding alternatives.

Unmanned Aircraft System Control and ATC Communications Bandwidth Requirements

NASA Technical Reports Server (NTRS)

Henriksen, Steve

2008-01-01

There are significant activities taking place to establish the procedures and requirements for safe and routine operation of unmanned aircraft systems (UAS) in the National Airspace System (NAS). Among the barriers to overcome in achieving this goal is the lack of sufficient frequency spectrum necessary for the UAS control and air traffic control (ATC) communications links. This shortcoming is compounded by the fact that the UAS control communications links will likely be required to operate in protected frequency spectrum, just as ATC communications links are, because they relate to "safety and regularity of flight." To support future International Telecommunications Union (ITU) World Radio Conference (WRC) agenda items concerning new frequency allocations for UAS communications links, and to augment the Future Communications Study (FCS) Technology Evaluation Group efforts, NASA Glenn Research Center has sponsored a task to estimate the UAS control and ATC communications bandwidth requirements for safe, reliable, and routine operation of UAS in the NAS. This report describes the process and results of that task. The study focused on long-term bandwidth requirements for UAS approximately through 2030.

The internal audit of clinical areas: a pilot of the internal audit methodology in a health service emergency department.

PubMed

Brown, Alison; Santilli, Mario; Scott, Belinda

2015-12-01

Governing bodies of health services need assurance that major risks to achieving the health service objectives are being controlled. Currently, the main assurance mechanisms generated within the organization are through the review of implementation of policies and procedures and review of clinical audits and quality data. The governing bodies of health services need more robust, objective data to inform their understanding of the control of clinical risks. Internal audit provides a methodological framework that provides independent and objective assurance to the governing body on the control of significant risks. The article describes the pilot of the internal audit methodology in an emergency unit in a health service. An internal auditor was partnered with a clinical expert to assess the application of clinical criteria based on best practice guidelines. The pilot of the internal audit of a clinical area was successful in identifying significant clinical risks that required further management. The application of an internal audit methodology to a clinical area is a promising mechanism to gain robust assurance at the governance level regarding the management of significant clinical risks. This approach needs further exploration and trial in a range of health care settings. © The Author 2015. Published by Oxford University Press in association with the International Society for Quality in Health Care; all rights reserved.

Technical skill improvement with surgical preparatory courses: What advantages are reflected in residency?

PubMed

Green, Courtney A; Huang, Emily; Zhao, Nina W; O'Sullivan, Patricia S; Kim, Edward; Chern, Hueylan

2017-11-01

Sustainability of skill acquisition gained from graduating medical student (GMS) preparatory courses remains uncertain. GMS skills were assessed before (T1) and after a preparatory course (T2) and then again 2 (T3) and 4 (T4) months into residency and compared to surgical interns without such a course. In April, GMS took the preparatory course. In July-August all interns participated in a basic skills curriculum. Learners completed four technical exercises pre/post each course. Three surgeons scored performances. GMS scores were compared across the 4 time points. Control interns were compared at T3 and T4. Thirty-two interns completed all pre/post course assessments (T3 and T4); seven of those were GMSs. GMS scores increased from 74.5%(T1) to 94.2%(T2) (p < 0.001), and were maintained into residency. Control interns also improved (65.8%(T3) to 91.8%(T4), p < 0.001). GMS-interns scored higher starting residency compared to control interns (T3, 89.08% vs 65.03%, p < 0.001). These findings support existing literature and demonstrate that students maintain their skills into residency. Preparatory courses provide a head start. Without such course, interns require a steep learning curve. Copyright © 2017 Elsevier Inc. All rights reserved.

29 CFR 95.22 - Payment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ORGANIZATIONS, AND WITH COMMERCIAL ORGANIZATIONS, FOREIGN GOVERNMENTS, ORGANIZATIONS UNDER THE JURISDICTION OF FOREIGN GOVERNMENTS, AND INTERNATIONAL ORGANIZATIONS Post-Award Requirements Financial and Program... recipient, and (2) Financial management systems that meet the standards for fund control and accountability...

29 CFR 95.22 - Payment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ORGANIZATIONS, AND WITH COMMERCIAL ORGANIZATIONS, FOREIGN GOVERNMENTS, ORGANIZATIONS UNDER THE JURISDICTION OF FOREIGN GOVERNMENTS, AND INTERNATIONAL ORGANIZATIONS Post-Award Requirements Financial and Program... recipient, and (2) Financial management systems that meet the standards for fund control and accountability...

Simple, Internally Adjustable Valve

NASA Technical Reports Server (NTRS)

Burley, Richard K.

1990-01-01

Valve containing simple in-line, adjustable, flow-control orifice made from ordinary plumbing fitting and two allen setscrews. Construction of valve requires only simple drilling, tapping, and grinding. Orifice installed in existing fitting, avoiding changes in rest of plumbing.

Spacecraft Thermal Control

NASA Technical Reports Server (NTRS)

Birur, Gajanana C.; Siebes, Georg; Swanson, Theodore D.; Powers, Edward I. (Technical Monitor)

2001-01-01

Thermal control of the spacecraft is typically achieved by removing heat from the spacecraft parts that tend to overheat and adding heat to the parts that tend get too cold. The equipment on the spacecraft can get very hot if it is exposed to the sun or have internal heat generation. The pans also can get very cold if they are exposed to the cold of deep space. The spacecraft and instruments must be designed to achieve proper thermal balance. The combination of the spacecraft's external thermal environment, its internal heat generation (i.e., waste heat from the operation of electrical equipment), and radiative heat rejection will determine this thermal balance. It should also be noted that this is seldom a static situation, external environmental influences and internal heat generation are normally dynamic variables which change with time. Topics discussed include thermal control system components, spacecraft mission categories, spacecraft thermal requirements, space thermal environments, thermal control hardware, launch and flight operations, advanced technologies for future spacecraft,

Accreditation of Individualized Quality Control Plans by the College of American Pathologists.

PubMed

Hoeltge, Gerald A

2017-03-01

The Laboratory Accreditation Program of the College of American Pathologists (CAP) began in 2015 to allow accredited laboratories to devise their own strategies for quality control of laboratory testing. Participants now have the option to implement individualized quality control plans (IQCPs). Only nonwaived testing that features an internal control (built-in, electronic, or procedural) is eligible for IQCP accreditation. The accreditation checklists that detail the requirements have been peer-reviewed by content experts on CAP's scientific resource committees and by a panel of accreditation participants. Training and communication have been key to the successful introduction of the new IQCP requirements. Copyright © 2016 Elsevier Inc. All rights reserved.

Measurement of Epidermal Growth Factor Receptor-Derived Signals Within Plasma Membrane Clathrin Structures.

PubMed

Lucarelli, Stefanie; Delos Santos, Ralph Christian; Antonescu, Costin N

2017-01-01

The epidermal growth factor (EGF) receptor (EGFR) is an important regulator of cell growth, proliferation, survival, migration, and metabolism. EGF binding to EGFR triggers the activation of the receptor's intrinsic kinase activity, in turn eliciting the recruitment of many secondary signaling proteins and activation of downstream signals, such as the activation of phosphatidylinositol-3-kinase (PI3K) and Akt, a process requiring the phosphorylation of Gab1. While the identity of many signals that can be activated by EGFR has been revealed, how the spatiotemporal organization of EGFR signaling within cells controls receptor outcome remains poorly understood. Upon EGF binding at the plasma membrane, EGFR is internalized by clathrin-mediated endocytosis following recruitment to clathrin-coated pits (CCPs). Further, plasma membrane CCPs, but not EGFR internalization, are required for EGF-stimulated Akt phosphorylation. Signaling intermediates such as phosphorylated Gab1, which lead to Akt phosphorylation, are enriched within CCPs upon EGF stimulation. These findings indicate that some plasma membrane CCPs also serve as signaling microdomains required for certain facets of EGFR signaling and are enriched in key EGFR signaling intermediates. Understanding how the spatiotemporal organization of EGFR signals within CCP microdomains controls receptor signaling outcome requires imaging methods that can systematically resolve and analyze the properties of CCPs, EGFR and key signaling intermediates. Here, we describe methods using total internal reflection fluorescence microscopy imaging and analysis to systematically study the enrichment of EGFR and key EGFR-derived signals within CCPs.

47 CFR 90.475 - Operation of internal transmitter control systems in specially equipped systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... systems involving fixed systems whose base stations are controlled by such systems may automatically access these base stations through the microwave or operational fixed systems from positions in the PSTN, so long as the base stations and mobile units meet the requirements of § 90.483 and if a separate...

The Usefulness of Quality Assurance for University Management and Academic Staff: A Case Study of Finland and Iceland

ERIC Educational Resources Information Center

Haapakorpi, Arja; Geirsdóttir, Guðrún; Jóhannsdóttir, Gyða

2013-01-01

With quality assurance related to the Bologna goals, universities are required to fulfil internationally accepted standardized criteria of quality. This tends to reinforce control in assessment. However, control-oriented evaluations seem to lack meaning for academic staff. The article explored the possibilities and space for improvement-oriented…

Estimating the Shadow Economy,

DTIC Science & Technology

1985-01-01

collected through a state franchised monopoly, selling primarily to industrial customers. The other is a sales tax on the purchase of food; S it is... internal control requirements that limit their ability to do so. In light of this, the use of aggregate tax burden as an indicator of the incentive...Economy? An International Cross Section Analysis," Southern Economic Journal, 49 (January 1983a). Frey, Bruno, and Hannelore Weck, "Estimating the

Space station contamination control study: Internal combustion, phase 1

NASA Technical Reports Server (NTRS)

Ruggeri, Robert T.

1987-01-01

Contamination inside Space Station modules was studied to determine the best methods of controlling contamination. The work was conducted in five tasks that identified existing contamination control requirements, analyzed contamination levels, developed outgassing specification for materials, wrote a contamination control plan, and evaluated current materials of offgassing tests used by NASA. It is concluded that current contamination control methods can be made to function on the Space Station for up to 1000 days, but that current methods are deficient for periods longer than about 1000 days.

Mentoring SFRM: A New Approach to International Space Station Flight Control Training

NASA Technical Reports Server (NTRS)

Huning, Therese; Barshi, Immanuel; Schmidt, Lacey

2009-01-01

The Mission Operations Directorate (MOD) of the Johnson Space Center is responsible for providing continuous operations support for the International Space Station (ISS). Operations support requires flight controllers who are skilled in team performance as well as the technical operations of the ISS. Space Flight Resource Management (SFRM), a NASA adapted variant of Crew Resource Management (CRM), is the competency model used in the MOD. ISS flight controller certification has evolved to include a balanced focus on development of SFRM and technical expertise. The latest challenge the MOD faces is how to certify an ISS flight controller (Operator) to a basic level of effectiveness in 1 year. SFRM training uses a twopronged approach to expediting operator certification: 1) imbed SFRM skills training into all Operator technical training and 2) use senior flight controllers as mentors. This paper focuses on how the MOD uses senior flight controllers as mentors to train SFRM skills.

Environmental Law and the Export of Pollution.

ERIC Educational Resources Information Center

Davis, John F.

1984-01-01

Environmental problems do not stop at state boundaries; they reach beyond local or national jurisdictions and require international control. Problems concerning air quality, water pollution, and indirect pollution are discussed. Environmental legislation can have a significant impact. (RM)

15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

Code of Federal Regulations, 2011 CFR

2011-01-01

... Triangular Transactions Involving Commodities Covered by a U.S. Import Certificate § 748.10(e). 0694-0012... Delivery Verification Certificate §§ 748.13 and 762.2(b). 0694-0017 International Import Certificate § 748... Assurance Requirement of License Exception TSR (Technology and Software Under Restriction) §§ 740.3(d) and...

Atmospheric effects on inlets for supersonic cruise aircraft

NASA Technical Reports Server (NTRS)

Cole, G. L.

1977-01-01

Mixed-compression inlet dynamic behavior in the vicinity of unstart, was simulated and analyzed to investigate time response of an inlet's normal shock to independent disturbances in ambient temperature and pressure and relative velocity (longitudinal gust), with and without inlet controls active. The results indicate that atmospheric disturbances may be more important than internal disturbances in setting inlet controls requirements because they are usually not anticipated and because normal shock response to rapid atmospheric disturbances is not attenuated by the inlet, as it is for engine induced disturbances. However, before inlet control requirements can be fully assessed, more statistics on extreme atmospheric disturbances are needed.

A user's guide to the Flexible Spacecraft Dynamics and Control Program

NASA Technical Reports Server (NTRS)

Fedor, J. V.

1984-01-01

A guide to the use of the Flexible Spacecraft Dynamics Program (FSD) is presented covering input requirements, control words, orbit generation, spacecraft description and simulation options, and output definition. The program can be used in dynamics and control analysis as well as in orbit support of deployment and control of spacecraft. The program is applicable to inertially oriented spinning, Earth oriented or gravity gradient stabilized spacecraft. Internal and external environmental effects can be simulated.

Opposing effects of oxytocin on overt compliance and lasting changes to memory.

PubMed

Edelson, Micah G; Shemesh, Maya; Weizman, Abraham; Yariv, Shahak; Sharot, Tali; Dudai, Yadin

2015-03-01

From infancy we learn to comply with societal norms. However, overt compliance is not necessarily accompanied by a change in internal beliefs. The neuromodulatory processes underlying these different phenomena are not yet understood. Here, we test the role of oxytocin in controlling overt compliance versus internalization of information delivered by a social source. After intranasal oxytocin administration, participants showed enhanced compliance to the erroneous opinion of others. However, this expression was coupled with a decrease in the influence of others on long-term memories. Our data suggest that this dissociation may result from reduced conflict in the face of social pressure, which increases immediate conforming behavior, but reduces processing required for deep encoding. These findings reveal a neurobiological control system that oppositely affects internalization and overt compliance.

Laser interferometer space antenna dynamics and controls model

NASA Astrophysics Data System (ADS)

Maghami, Peiman G.; Tupper Hyde, T.

2003-05-01

A 19 degree-of-freedom (DOF) dynamics and controls model of a laser interferometer space antenna (LISA) spacecraft has been developed. This model is used to evaluate the feasibility of the dynamic pointing and positioning requirements of a typical LISA spacecraft. These requirements must be met for LISA to be able to successfully detect gravitational waves in the frequency band of interest (0.1-100 mHz). The 19-DOF model includes all rigid-body degrees of freedom. A number of disturbance sources, both internal and external, are included. Preliminary designs for the four control systems that comprise the LISA disturbance reduction system (DRS) have been completed and are included in the model. Simulation studies are performed to demonstrate that the LISA pointing and positioning requirements are feasible and can be met.

Letter to the Editor: On "Advantages and disadvantages of stiffness instructions when studying postural control" by C.T. Bonnet: You just can't win: Advantages and disadvantages of the postural stability requirement.

PubMed

Lajoie, Y; Richer, N; Jehu, D A; Polskaia, N; Saunders, D

2016-05-01

In the examination of postural control, instructions to stand as still as possible are common and promote a relatively unnatural sway pattern. The validity of the stability requirement is discussed in the present commentary in response to the discussion initiated by Cedrick T. Bonnet. The advantages of using the stability requirement include: evaluating unbiased postural control, reducing variability in postural sway, manipulating focus of attention, examining the ability to maintain an upright stance, and ecological validity of testing. The disadvantages include: constraining natural postural sway, increasing the complexity of the control condition, promoting an internal focus of attention, and reducing the ability to detect exploratory behaviour. After evaluating the aforementioned advantages and disadvantages, the present commentary suggests that researchers should strive to provide specific instructions to maintain feet, arm and eye position without specifically requiring participants to reduce their postural sway. Copyright © 2015 Elsevier B.V. All rights reserved.

48 CFR 2146.201 - General.

Code of Federal Regulations, 2012 CFR

2012-10-01

... LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality... acquired under the FEGLI Program contract conform to the contract's quality requirements. (b) OPM will make an initial evaluation of the Contractor's system of internal controls under the quality assurance...

48 CFR 2146.201 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality... acquired under the FEGLI Program contract conform to the contract's quality requirements. (b) OPM will make an initial evaluation of the Contractor's system of internal controls under the quality assurance...

48 CFR 2146.201 - General.

Code of Federal Regulations, 2013 CFR

2013-10-01

... LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality... acquired under the FEGLI Program contract conform to the contract's quality requirements. (b) OPM will make an initial evaluation of the Contractor's system of internal controls under the quality assurance...

48 CFR 2146.201 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality... acquired under the FEGLI Program contract conform to the contract's quality requirements. (b) OPM will make an initial evaluation of the Contractor's system of internal controls under the quality assurance...

48 CFR 2146.201 - General.

Code of Federal Regulations, 2014 CFR

2014-10-01

... LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality... acquired under the FEGLI Program contract conform to the contract's quality requirements. (b) OPM will make an initial evaluation of the Contractor's system of internal controls under the quality assurance...

Measuring Software Product Quality: The ISO 25000 Series and CMMI

DTIC Science & Technology

2004-06-14

performance objectives” covers objectives and requirements for product quality, service quality , and process performance. Process performance objectives...such that product quality, service quality , and process performance attributes are measurable and controlled throughout the project (internal and

Perceiving pain in others: validation of a dual processing model.

PubMed

McCrystal, Kalie N; Craig, Kenneth D; Versloot, Judith; Fashler, Samantha R; Jones, Daniel N

2011-05-01

Accurate perception of another person's painful distress would appear to be accomplished through sensitivity to both automatic (unintentional, reflexive) and controlled (intentional, purposive) behavioural expression. We examined whether observers would construe diverse behavioural cues as falling within these domains, consistent with cognitive neuroscience findings describing activation of both automatic and controlled neuroregulatory processes. Using online survey methodology, 308 research participants rated behavioural cues as "goal directed vs. non-goal directed," "conscious vs. unconscious," "uncontrolled vs. controlled," "fast vs. slow," "intentional (deliberate) vs. unintentional," "stimulus driven (obligatory) vs. self driven," and "requiring contemplation vs. not requiring contemplation." The behavioural cues were the 39 items provided by the PROMIS pain behaviour bank, constructed to be representative of the diverse possibilities for pain expression. Inter-item correlations among rating scales provided evidence of sufficient internal consistency justifying a single score on an automatic/controlled dimension (excluding the inconsistent fast vs. slow scale). An initial exploratory factor analysis on 151 participant data sets yielded factors consistent with "controlled" and "automatic" actions, as well as behaviours characterized as "ambiguous." A confirmatory factor analysis using the remaining 151 data sets replicated EFA findings, supporting theoretical predictions that observers would distinguish immediate, reflexive, and spontaneous reactions (primarily facial expression and paralinguistic features of speech) from purposeful and controlled expression (verbal behaviour, instrumental behaviour requiring ongoing, integrated responses). There are implicit dispositions to organize cues signaling pain in others into the well-defined categories predicted by dual process theory. Copyright © 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Advantages and disadvantages of stiffness instructions when studying postural control.

PubMed

Bonnet, Cédrick T

2016-05-01

To understand the maintenance of upright stance, researchers try to discover the fundamental mechanisms and attentional resources devoted to postural control and eventually to the performance of other tasks (e.g., counting in the head). During their studies, some researchers require participants to stand as steady as possible and other simply ask participants to stand naturally. Surprisingly, a clear and direct explanation of the usefulness of the steadiness requirement seems to be lacking, both in experimental and methodological discussions. Hence, the objective of the present note was to provide advantages and disadvantages of this steadiness requirement in studies of postural control. The advantages may be to study fundamental postural control, to eliminate useless postural variability, to control spurious body motions and to control the participants' thoughts. As disadvantages, this steadiness requirement only leads to study postural control in unnatural upright stance, it changes the focus of attention (internal vs. external) and the nature of postural control (unconscious vs. conscious), it increases the difficulty of a supposedly easy control task and it eliminates or reduces the opportunity to record exploratory behaviors. When looking carefully at the four advantages of the steadiness requirement, one can believe that they are, in fact, more disadvantageous than advantageous. Overall therefore, this requirement seems illegitimate and it is proposed that researchers should not use it in the study of postural control. They may use this requirement only if they search to know the limit until which participants can consciously reduce their postural sway. Copyright © 2015 Elsevier B.V. All rights reserved.

Copper-Based Aquatic Algaecide Adsorption and Accumulation Kinetics: Influence of Exposure Concentration and Duration for Controlling the Cyanobacterium Lyngbya wollei.

PubMed

Bishop, West M; Lynch, Clayton L; Willis, Ben E; Cope, W Gregory

2017-09-01

Filamentous mat-forming cyanobacteria are increasingly impairing uses of freshwater resources. To effectively manage, a better understanding of control measures is needed. Copper (Cu)-based algaecide formulations are often applied to reactively control nuisance cyanobacterial blooms. This laboratory research assessed typical field exposure scenarios for the ability of Cu to partition to, and accumulate in Lyngbya wollei. Exposure factors (Cu concentration × duration) of 4, 8, 16, 24, 32 h were tested across three aqueous Cu concentrations (1, 2, 4 ppm). Results indicated that internally accumulated copper correlated with control of L. wollei, independent of adsorbed copper. L. wollei control was determined by filament viability and chlorophyll a concentrations. Similar exposure factors elicited similar internalized copper levels and consequent responses of L. wollei. Ultimately, a "concentration-exposure-time" (CET) model was created to assist water resource managers in selecting an appropriate treatment regime for a specific in-water infestation. By assessing the exposure concentration and duration required to achieve the internal threshold of copper (i.e., critical burden) that elicits control, water management objectives can be achieved while simultaneously decreasing the environmental loading of copper and potential for non-target species risks.

Intrinsic Sensing and Evolving Internal Model Control of Compact Elastic Module for a Lower Extremity Exoskeleton

PubMed Central

Wang, Likun; Du, Zhijiang; Dong, Wei; Shen, Yi; Zhao, Guangyu

2018-01-01

To achieve strength augmentation, endurance enhancement, and human assistance in a functional autonomous exoskeleton, control precision, back drivability, low output impedance, and mechanical compactness are desired. In our previous work, two elastic modules were designed for human–robot interaction sensing and compliant control, respectively. According to the intrinsic sensing properties of the elastic module, in this paper, only one compact elastic module is applied to realize both purposes. Thus, the corresponding control strategy is required and evolving internal model control is proposed to address this issue. Moreover, the input signal to the controller is derived from the deflection of the compact elastic module. The human–robot interaction is considered as the disturbance which is approximated by the output error between the exoskeleton control plant and evolving forward learning model. Finally, to verify our proposed control scheme, several experiments are conducted with our robotic exoskeleton system. The experiment shows a satisfying result and promising application feasibility. PMID:29562684

Intrinsic Sensing and Evolving Internal Model Control of Compact Elastic Module for a Lower Extremity Exoskeleton.

PubMed

Wang, Likun; Du, Zhijiang; Dong, Wei; Shen, Yi; Zhao, Guangyu

2018-03-19

To achieve strength augmentation, endurance enhancement, and human assistance in a functional autonomous exoskeleton, control precision, back drivability, low output impedance, and mechanical compactness are desired. In our previous work, two elastic modules were designed for human-robot interaction sensing and compliant control, respectively. According to the intrinsic sensing properties of the elastic module, in this paper, only one compact elastic module is applied to realize both purposes. Thus, the corresponding control strategy is required and evolving internal model control is proposed to address this issue. Moreover, the input signal to the controller is derived from the deflection of the compact elastic module. The human-robot interaction is considered as the disturbance which is approximated by the output error between the exoskeleton control plant and evolving forward learning model. Finally, to verify our proposed control scheme, several experiments are conducted with our robotic exoskeleton system. The experiment shows a satisfying result and promising application feasibility.

Attitude control of an orbiting space vehicle.

NASA Technical Reports Server (NTRS)

Sutherlin, D. W.; Boland, J. S. , III; Borelli, M. T.

1971-01-01

Study of the normal and clamped modes of operation and dynamic response characteristics of the gimbaled control moment gyro (CMG) designed to fulfill the stringent pointing requirements of the Skylab telescope mount when the spacecraft is under the influence of both external and internal torques. The results indicate that the clamped mode of operation provides a feasible approach for significantly improving the system characteristics.

Design and Development of a CPCI-Based Electronics Package for Space Station Experiments

NASA Technical Reports Server (NTRS)

Kolacz, John S.; Clapper, Randy S.; Wade, Raymond P.

2006-01-01

The NASA John H. Glenn Research Center is developing a Compact-PCI (CPCI) based electronics package for controlling space experiment hardware on the International Space Station. Goals of this effort include an easily modified, modular design that allows for changes in experiment requirements. Unique aspects of the experiment package include a flexible circuit used for internal interconnections and a separate enclosure (box in a box) for controlling 1 kW of power for experiment fuel heating requirements. This electronics package was developed as part of the FEANICS (Flow Enclosure Accommodating Novel Investigations in Combustion of Solids) mini-facility which is part of the Fluids and Combustion Facility s Combustion Integrated Rack (CIR). The CIR will be the platform for future microgravity combustion experiments and will reside on the Destiny Module of the International Space Station (ISS). The FEANICS mini-facility will be the primary means for conducting solid fuel combustion experiments in the CIR on ISS. The main focus of many of these solid combustion experiments will be to conduct applied scientific investigations in fire-safety to support NASA s future space missions. A description of the electronics package and the results of functional testing are the subjects of this report. The report concludes that the use of innovative packaging methods combined with readily available COTS hardware can provide a modular electronics package which is easily modified for changing experiment requirements.

Dynamics and control of detumbling a disabled spacecraft during rescue operations

NASA Technical Reports Server (NTRS)

Kaplan, M. H.

1973-01-01

Results of a two-year research effort on dynamics and control of detumbling a disabled spacecraft during rescue operations are summarized. Answers to several basic questions about associated techniques and hardware requirements were obtained. Specifically, efforts have included development of operational procedures, conceptual design of remotely controlled modules, feasibility of internal moving mass for stabilization, and optimal techniques for minimum-time detumbling. Results have been documented in several reports and publications.

Simulation studies of STOL airplane operations in metropolitan downtown and airport air traffic control environments

NASA Technical Reports Server (NTRS)

Sawyer, R. H.; Mclaughlin, M. D.

1974-01-01

The operating problems and equipment requirements for STOL airplanes in terminal area operations in simulated air traffic control (ATC) environments were studied. These studies consisted of Instrument Flight Rules (IFR) arrivals and departures in the New York area to and from a downtown STOL port, STOL runways at John F. Kennedy International Airport, or STOL runways at a hypothetical international airport. The studies were accomplished in real time by using a STOL airplane flight simulator. An experimental powered lift STOL airplane and two in-service airplanes having high aerodynamic lift (i.e., STOL) capability were used in the simulations.

Internal Controls Over the Army Military Equipment Baseline Valuation Effort

DTIC Science & Technology

2008-08-29

Equipment and required thai military equipment assets be capitalized and depreciated . The Under Secretary of Defense (Acquisition, Technology, and...Property, Plant, and Equipment and requires that military equipment assets be capitalized and depreciated . Prior to SFFAS No. 23, DoD expensed military...net book value of military equipment is the total acquisition cost minus the accumulated depreciation . The Army’s financial statements also include

[On the improvement of the legal support of the food safety in the conditions of trade and economic integration of states-members of the Customs union and the Russian Federation's accession to the WTO].

PubMed

Bragina, I V; Aksenova, O I; Bokit'ko, B G; Gorsky, A A

2013-01-01

In the article priority activities of The Federal Service for the Oversight of Consumer Protection and Welfare on improvement of standard legal support of safety of foodstuff and control of compliance of foodstuff to legislation requirements are reported. The main documents directed on harmonization of the international requirements with national ones and requirements of the Customs union on safety of foodstuff are submitted. Work within a framework of Russian Federation's accession to the WTO is described. And data on control of quality and safety of foodstuff are provided also.

KPMG Peat Marwick LLP Corporation of Mercer University Fiscal Year Ended June 30, 1995

DTIC Science & Technology

1997-06-11

The objective of a quality control review is to ensure that the audit was conducted in accordance with applicable standards and meets the auditing...requirements of the OMB Circular A-133. We conducted a quality control review of the audit working papers. We focused our review on the following...qualitative aspects of the audit : due professional care, planning, supervision, independence, quality control, internal controls, substantive testing, general and specific compliance testing, and the Schedule of Federal Awards.

Overview of Carbon Dioxide Control Issues During International Space Station/Space Shuttle Joint Docked Operations

NASA Technical Reports Server (NTRS)

Matty, Christopher M.

2010-01-01

Crewed space vehicles have a common requirement to remove the carbon dioxide (CO2) created by the metabolic processes of the crew. The space shuttle [Space Transportation System (STS)] and International Space Station (ISS) each have systems in place that allow control and removal of CO2 from the habitable cabin environment. During periods in which the space shuttle is docked to the ISS, known as "joint docked operations," the space shuttle and ISS share a common atmosphere environment. During this period, an elevated amount of CO2 is produced through the combined metabolic activity of the STS and ISS crews. This elevated CO2 production, together with the large effective atmosphere created by collective volumes of the docked vehicles, creates a unique set of requirements for CO2 removal. This paper will describe individual CO2 control plans implemented by STS and ISS engineering teams, as well as the integrated plans used when both vehicles are docked. The paper will also discuss some of the issues and anomalies experienced by both engineering teams.

Overview of Carbon Dioxide Control Issues During International Space Station/Space Shuttle Joint Docked Operations

NASA Technical Reports Server (NTRS)

Matty, Christopher M.; Hayley, Elizabeth P.

2009-01-01

Manned space vehicles have a common requirement to remove the Carbon Dioxide (CO2) created by the metabolic processes of the crew. The Space Shuttle and International Space Station (ISS) each have systems in place to allow control and removal of CO2 from the habitable cabin environment. During periods where the Space Shuttle is docked to ISS, known as joint docked operations, the Space Shuttle and ISS share a common atmosphere environment. During this period there is an elevated production of CO2 caused by the combined metabolic activity of the Space Shuttle and ISS crew. This elevated CO2 production, combined with the large effective atmosphere created by the collective volumes of the docked vehicles, creates a unique set of requirements for CO2 removal. This paper will describe the individual CO2 control plans implemented by the Space Shuttle and ISS engineering teams, as well as the integrated plans used when both vehicles are docked. In addition, the paper will discuss some of the issues and anomalies experienced by both engineering teams.

Controls, health assessment, and conditional monitoring for large, reusable, liquid rocket engines

NASA Technical Reports Server (NTRS)

Cikanek, H. A., III

1986-01-01

Past and future progress in the performance of control systems for large, liquid rocket engines typified such as current state-of-the-art, the Shuttle Main Engine (SSME), is discussed. Details of the first decade of efforts, which culminates in the F-1 and J-2 Saturn engines control systems, are traced, noting problem modes and improvements which were implemented to realize the SSME. Future control system designs, to accommodate the requirements of operation of engines for a heavy lift launch vehicle, an orbital transfer vehicle and the aerospace plane, are summarized. Generic design upgrades needed include an expanded range of fault detection, maintenance as-needed instead of as-scheduled, reduced human involvement in engine operations, and increased control of internal engine states. Current NASA technology development programs aimed at meeting the future control system requirements are described.

Evaluation of the Ciba Corning Biotrack 512 coagulation monitor for the control of oral anticoagulation.

PubMed Central

Jennings, I; Luddington, R J; Baglin, T

1991-01-01

The Ciba Corning Biotrack 512 coagulation monitor requires a minimal degree of technical expertise to operate, and is already in use for near-patient testing. This study evaluated the monitor for possible use in decentralised control of oral anticoagulant treatment. The monitor compared well with Manchester Reagent, suggesting that it could be used in areas where this thromboplastin is used for centralised control. The inability of the monitor to allow for locally determined geometric mean normal prothrombin times in the calculation of the International Normalised Ratio (INR), and possibly the high International Sensitivity Index (ISI) of the thromboplastin used with the monitor, resulted in poor comparability with some other thromboplastins, particularly Thrombotest. These problems need to be addressed if the monitor is to be used for decentralised anticoagulant control. PMID:1752987

Modulated solar pressure-based surface shape control of paraboloid space reflectors with an off-axis Sun-line

NASA Astrophysics Data System (ADS)

Liu, Jiafu; McInnes, Colin R.

2018-03-01

This paper considers utilizing solar radiation pressure (SRP) to actively control the surface shape of a reflector consisting of a rigid hoop and slack membrane with embedded reflectivity control devices. The full nonlinear static partial differential governing equations for a reflector with negligible elastic deformations are established for the circumferential, radial and transverse directions respectively, in which the SRP force with ideal/non-perfect models, the centripetal force caused by the rotation of the reflector and the internal stresses are considered. The inverse problem is then formulated by assuming that the required surface shape is known, and then the governing algebraic-differential equations used to determine the required surface reflectivity, together with the internal stresses where are presented accordingly. The validity of the approach is verified by comparing the results in this paper with corresponding published results as benchmarks. The feasible regions of the angular velocity and Sun angle for a paraboloidal reflector with an invariant radius and focal length (case 1), and the achievable focal lengths with a specific angular velocity and Sun angle (case 2) are presented for two SRP models respectively, both by considering the constraints on the reflectivity and internal stresses. It is then found that the feasible region is toward a larger angular velocity and Sun angle when using the non-perfect SRP model, compared with the ideal one in case 1. The angular velocity of the spinning reflector should be within a certain range to make the required reflectivity profiles within a practical range, i.e., [0, 0.88], as indicated from prior NASA solar sail studies. In case 2, it is found that the smallest achievable focal length of the reflector with the non-perfect SRP model is smaller than that with the ideal SRP model. It is also found that the stress level is extremely low for all cases considered and that the typical real material strength available for the reflector is sufficient to withstand these internal stresses.

An Analysis of Internal Controls for DoD Contract Management

DTIC Science & Technology

2015-12-01

61 xiv THIS PAGE INTENTIONALLY LEFT BLANK xv LIST OF ACRONYMS AND ABBREVIATIONS BCA Business Case Analysis BPA ...indefinite quantity (IDIQ) and blanket purchase agreements ( BPA ), which can provide the government flexibility on ordering recurring requirements. Figure 5

40 CFR Table 10 to Subpart Dddd of... - Applicability of General Provisions to Subpart DDDD

Code of Federal Regulations, 2010 CFR

2010-07-01

... plan approval procedures; performance audit requirements; internal and external QA procedures for... control plan on record for 5 years. Keep old versions for 5 years after revisions Yes. § 63.8(e) CMS...

40 CFR Table 10 to Subpart Ddddd... - Applicability of General Provisions to Subpart DDDDD

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements; and internal and external QA procedures for testing Yes. § 63.7(d) Testing Facilities... must keep quality control plan on record for the life of the affected source. Keep old versions for 5...

40 CFR Table 3 to Subpart Cccccc... - Applicability of General Provisions

Code of Federal Regulations, 2010 CFR

2010-07-01

... procedures; performance audit requirements; internal and external QA procedures for testing Yes. § 63.7(d... quality control plan on record for 5 years; keep old versions for 5 years after revisions No. § 63.8(e...

40 CFR Table 7 to Subpart Ppppp of... - Applicability of General Provisions to Subpart PPPPP

Code of Federal Regulations, 2010 CFR

2010-07-01

... Yes. 3. Performance audit requirements Yes. 4. Internal and external QA procedures for testing Yes... keep quality control plan on record for 5 years. Keep old versions for 5 years after revisions Yes...

77 FR 72425 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... with these requirements through an exam-based review of the ETP Holder's internal controls. [[Page...-NYSEARCA-2012-129 on the subject line. Paper Comments Send paper comments in triplicate to Elizabeth M...

A method exploiting direct communication between phasor measurement units for power system wide-area protection and control algorithms.

PubMed

Almas, Muhammad Shoaib; Vanfretti, Luigi

2017-01-01

Synchrophasor measurements from Phasor Measurement Units (PMUs) are the primary sensors used to deploy Wide-Area Monitoring, Protection and Control (WAMPAC) systems. PMUs stream out synchrophasor measurements through the IEEE C37.118.2 protocol using TCP/IP or UDP/IP. The proposed method establishes a direct communication between two PMUs, thus eliminating the requirement of an intermediate phasor data concentrator, data mediator and/or protocol parser and thereby ensuring minimum communication latency without considering communication link delays. This method allows utilizing synchrophasor measurements internally in a PMU to deploy custom protection and control algorithms. These algorithms are deployed using protection logic equations which are supported by all the PMU vendors. Moreover, this method reduces overall equipment cost as the algorithms execute internally in a PMU and therefore does not require any additional controller for their deployment. The proposed method can be utilized for fast prototyping of wide-area measurements based protection and control applications. The proposed method is tested by coupling commercial PMUs as Hardware-in-the-Loop (HIL) with Opal-RT's eMEGAsim Real-Time Simulator (RTS). As illustrative example, anti-islanding protection application is deployed using proposed method and its performance is assessed. The essential points in the method are: •Bypassing intermediate phasor data concentrator or protocol parsers as the synchrophasors are communicated directly between the PMUs (minimizes communication delays).•Wide Area Protection and Control Algorithm is deployed using logic equations in the client PMU, therefore eliminating the requirement for an external hardware controller (cost curtailment)•Effortless means to exploit PMU measurements in an environment familiar to protection engineers.

An Exemplary Case of Promotion Activities and Taste Panels from the Perspective of Tobacco Control

PubMed Central

Mutlu, Erdem İlker; Seydioğulları, Mustafa; Aslan, Dilek

2015-01-01

The Framework Convention on Tobacco Control is a multilateral international agreement which has been generated to protect the health of nationals and nations against the hazards/risks of tobacco and its products. All high contracting parties to the Convention undertake the international responsibility to fulfill all the requirements of the Convention’s articles in national legal systems. The Framework Convention on Tobacco Control has a considerable place among other international conventions on health. Within the self-executing desing/system of the Convention, a vital regulation focuses on banning the advertisement, promotion, and sponsorship of tobacco products. Because they are one of the various components of tobacco advertisement, promotion, and sponsorship, taste panels should be assessed within the content of the Convention. Thus, banning taste panel activities is an important step in tobacco control and it is one of the basic areas where medical and law sciences should collaborate. In this article, a comprehensive frame has been drawn to the issue and recommendations have been developed for the future. PMID:29404102

The influence of motion control shoes on the running gait of mature and young females.

PubMed

Lilley, Kim; Stiles, Vicky; Dixon, Sharon

2013-03-01

This study compared the running gait of mature and young females, and investigated the effect of a motion control shoe. First, it was hypothesised that in a neutral shoe, mature females would display significantly greater rearfoot eversion, knee internal rotation and external adductor moments when compared to a younger group. Secondly, the motion control shoe would reduce rearfoot eversion and knee internal rotation in both groups. Thirdly it was hypothesised that the motion control shoe would increase knee external adductor moment, through an increase in knee varus and moment arm. 15 mature (40-60 years) and 15 young (18-25 years) females performed 10 running trials at 3.5ms(-1)±5% over a force platform. Two shoes were tested, the Adidas Supernova Glide (neutral), and the Adidas Supernova Sequence (motion control). Ankle and knee joint dynamics were analysed for the right leg, and the mean of ten trials was calculated. Joint moments were calculated using inverse dynamics. In the neutral condition, mature females presented greater peak rearfoot eversion, knee internal rotation, and external adductor moments than young females (p<0.05). A motion control shoe significantly reduced peak rearfoot eversion and knee internal rotation among both groups (p<0.05). No between shoe differences in knee external adductor moment were observed. A motion control shoe is recommended to reduce risk of injury associated with rearfoot eversion and knee internal rotation in mature females. However since the knee external adductor moment is a variable commonly associated with medial knee loading it is suggested that alternative design features are required to influence this moment. Copyright © 2012 Elsevier B.V. All rights reserved.

Vertical Position and Current Profile Measurements by Faraday-effect Polarimetry On EAST tokamak

NASA Astrophysics Data System (ADS)

Ding, Weixing; Liu, H. Q.; Jie, Y. X.; Brower, D. L.; Qian, J. P.; Zou, Z. Y.; Lian, H.; Wang, S. X.; Luo, Z. P.; Xiao, B. J.; Ucla Team; Asipp Team

2017-10-01

A primary goal for ITER and prospective fusion power reactors is to achieve controlled long-pulse/steady-state burning plasmas. For elongated divertor plasmas, both the vertical position and current profile have to be precisely controlled to optimize performance and prevent disruptions. An eleven-channel laser-based POlarimeter-INTerferometer (POINT) system has been developed for measuring the internal magnetic field in the EAST tokamak and can be used to obtain the plasma current profile and vertical position. Current profiles are determined from equilibrium reconstruction including internal magnetic field measurements as internal constraints. Horizontally-viewing chords at/near the mid-plane allow us to determine plasma vertical position non-inductively with subcentimeter spatial resolution and time response up to 1 s. The polarimeter-based position measurement, which does not require equilibrium reconstruction, is benchmarked against conventional flux loop measurements and can be exploited for feedback control. Work supported by US DOE through Grants No. DE-FG02-01ER54615 and No. DC-SC0010469.

Four GABAergic interneurons impose feeding restraint in Drosophila

PubMed Central

Pool, Allan-Hermann; Kvello, Pal; Mann, Kevin; Cheung, Samantha K.; Gordon, Michael D.; Wang, Liming; Scott, Kristin

2014-01-01

Summary Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establish a central feeding threshold which is required to inhibit consumption. Inactivation of these cells results in indiscriminate and excessive intake of all compounds, independent of taste quality or nutritional state. Conversely, acute activation of these neurons suppresses consumption of water and nutrients. The output from these neurons is required to gate activity in motor neurons that control meal initiation and consumption. Thus, our study reveals a new layer of inhibitory control in feeding circuits that is required to suppress a latent state of unrestricted and non-selective consumption. PMID:24991960

Optimal Control Design using an H(sub 2) Method for the Glovebox Integrated Microgravity Isolation Technology (G-Limit)

NASA Technical Reports Server (NTRS)

Calhoun, Philip C.; Hampton, R. David

2002-01-01

The acceleration environment on the International Space Station (ISS) will likely exceed the requirements of many micro-gravity experiments. The Glovebox Integrated Microgravity Isolation Technology (g-LIMIT) is being built by the NASA Marshall Space Flight Center to attenuate the nominal acceleration environment and provide some isolation for microgravity science experiments. G-LIMIT uses Lorentz (voice-coil) magnetic actuators to isolate a platform for mounting science payloads from the nominal acceleration environment. The system utilizes payload acceleration, relative position, and relative orientation measurements in a feedback controller to accomplish the vibration isolation task. The controller provides current commands to six magnetic actuators, producing the required experiment isolation from the ISS acceleration environment. This paper presents the development of a candidate control law to meet the acceleration attenuation requirements for the g-LIMIT experiment platform. The controller design is developed using linear optimal control techniques for frequency-weighted H(sub 2) norms. Comparison of the performance and robustness to plant uncertainty for this control design approach is included in the discussion.

Frequency Weighted H2 Control Design for the Glovebox Integrated Microgravity Isolation Technology (g-LIMIT)

NASA Technical Reports Server (NTRS)

Calhoun, Philip C.; Hampton, R. David

2004-01-01

The acceleration environment on the International Space Station (ISS) exceeds the requirements of many microgravity experiments. The Glovebox Integrated Microgravity Isolation Technology (g-LIMIT) has been built by the NASA Marshall Space Flight Center to attenuate the nominal acceleration environment and provide some isolation for microgravity science experiments. The g-LIMIT uses Lorentz (voice-coil) magnetic actuators to isolate a platform, for mounting science payloads, from the nominal acceleration environment. The system utilizes payload-acceleration, relative-position, and relative-orientation measurements in a feedback controller to accomplish the vibration isolation task. The controller provides current commands to six magnetic actuators, producing the required experiment isolation from the ISS acceleration environment. The present work documents the development of a candidate control law to meet the acceleration attenuation requirements for the g-LIMIT experiment platform. The controller design is developed using linear optimal control techniques for frequency-weighted H2 norms. Comparison of performance and robustness to plant uncertainty for this control design approach is included in the discussion. System performance is demonstrated in the presence of plant modeling error.

Optimal Control Design Using an H2 Method for the Glovebox Integrated Microgravity Isolation Technology (g-LIMIT)

NASA Technical Reports Server (NTRS)

Calhoun, Phillip C.; Hampton, R. David; Whorton, Mark S.

2001-01-01

The acceleration environment on the International Space Station (ISS) will likely exceed the requirements of many micro-gravity experiments. The Glovebox Integrated Microgravity Isolation Technology (g-LIMIT) is being built by the NASA Marshall Space Flight Center to attenuate the nominal acceleration environment and provide some isolation for micro-gravity science experiments. G-LIMIT uses Lorentz (voice-coil) magnetic actuators to isolate a platform for mounting science payloads from the nominal acceleration environment. The system utilizes payload acceleration, relative position, and relative orientation measurements in a feedback controller to accomplish the vibration isolation task. The controller provides current command to six magnetic actuators, producing the required experiment isolation from the ISS acceleration environment. This paper presents the development of a candidate control law to meet the acceleration attenuation requirements for the g-LIMIT experiment platform. The controller design is developed using linear optimal control techniques for both frequency-weighted H(sub 2) and H(sub infinity) norms. Comparison of the performance and robustness to plant uncertainty for these two optimal control design approaches are included in the discussion.

Environmental Control Subsystem Development

NASA Technical Reports Server (NTRS)

Laidlaw, Jacob; Zelik, Jonathan

2017-01-01

Kennedy Space Center's Launch Pad 39B, part of Launch Complex 39, is currently undergoing construction to prepare it for NASA's Space Launch System missions. The Environmental Control Subsystem, which provides the vehicle with an air or nitrogen gas environment, required development of its local and remote display screens. The remote displays, developed by NASA contractors and previous interns, were developed without complete functionality; the remote displays were revised, adding functionality to over 90 displays. For the local displays, multiple test procedures were developed to assess the functionality of the screens, as well as verify requirements. One local display screen was also developed.

Framework for establishing records control in hospitals as an ISO 9001 requirement.

PubMed

Al-Qatawneh, Lina

2017-02-13

Purpose The purpose of this paper is to present the process followed to control records in a Jordanian private community hospital as an ISO 9001:2008 standard requirement. Design/methodology/approach Under the hospital quality council's supervision, the quality management and development office staff were responsible for designing, planning and implementing the quality management system (QMS) using the ISO 9001:2008 standard. A policy for records control was established. An action plan for establishing the records control was developed and implemented. On completion, a coding system for records was specified to be used by hospital staff. Finally, an internal audit was performed to verify conformity to the ISO 9001:2008 standard requirements. Findings Successful certification by a neutral body ascertained that the hospital's QMS conformed to the ISO 9001:2008 requirements. A framework was developed that describes the records controlling process, which can be used by staff in any healthcare organization wanting to achieve ISO 9001:2008 accreditation. Originality/value Given the increased interest among healthcare organizations to achieve the ISO 9001 certification, the proposed framework for establishing records control is developed and is expected to be a valuable management tool to improve and sustain healthcare quality.

Development of internal models and predictive abilities for visual tracking during childhood

PubMed Central

Ego, Caroline; Yüksel, Demet

2015-01-01

The prediction of the consequences of our own actions through internal models is an essential component of motor control. Previous studies showed improvement of anticipatory behaviors with age for grasping, drawing, and postural control. Since these actions require visual and proprioceptive feedback, these improvements might reflect both the development of internal models and the feedback control. In contrast, visual tracking of a temporarily invisible target gives specific markers of prediction and internal models for eye movements. Therefore, we recorded eye movements in 50 children (aged 5–19 yr) and in 10 adults, who were asked to pursue a visual target that is temporarily blanked. Results show that the youngest children (5–7 yr) have a general oculomotor behavior in this task, qualitatively similar to the one observed in adults. However, the overall performance of older subjects in terms of accuracy at target reappearance and variability in their behavior was much better than the youngest children. This late maturation of predictive mechanisms with age was reflected into the development of the accuracy of the internal models governing the synergy between the saccadic and pursuit systems with age. Altogether, we hypothesize that the maturation of the interaction between smooth pursuit and saccades that relies on internal models of the eye and target displacement is related to the continuous maturation of the cerebellum. PMID:26510757

Development of internal models and predictive abilities for visual tracking during childhood.

PubMed

Ego, Caroline; Yüksel, Demet; Orban de Xivry, Jean-Jacques; Lefèvre, Philippe

2016-01-01

The prediction of the consequences of our own actions through internal models is an essential component of motor control. Previous studies showed improvement of anticipatory behaviors with age for grasping, drawing, and postural control. Since these actions require visual and proprioceptive feedback, these improvements might reflect both the development of internal models and the feedback control. In contrast, visual tracking of a temporarily invisible target gives specific markers of prediction and internal models for eye movements. Therefore, we recorded eye movements in 50 children (aged 5-19 yr) and in 10 adults, who were asked to pursue a visual target that is temporarily blanked. Results show that the youngest children (5-7 yr) have a general oculomotor behavior in this task, qualitatively similar to the one observed in adults. However, the overall performance of older subjects in terms of accuracy at target reappearance and variability in their behavior was much better than the youngest children. This late maturation of predictive mechanisms with age was reflected into the development of the accuracy of the internal models governing the synergy between the saccadic and pursuit systems with age. Altogether, we hypothesize that the maturation of the interaction between smooth pursuit and saccades that relies on internal models of the eye and target displacement is related to the continuous maturation of the cerebellum. Copyright © 2016 the American Physiological Society.

Minutes - Accredited Standards Committee on Mechanical Shock and Vibration, S2. U.S. Tag for ISO/TC108 Mechanical Vibration and Shock

DTIC Science & Technology

1991-08-02

if required) - Hanning Window - (4) averages (linear, non -overlapping) At the designated measurement positions suitable surfaces shall be provided such...these efforts of particular importance in order to remain competitive in the international arena with respect to noise control technology and noise...Organizational matters and reports on working grouos , including reports on letter ballots and international matters (continued) b) S3/WG39 (2) - Human

KSC-04pd1975

NASA Image and Video Library

2004-09-22

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, workers conduct a post-delivery verification test on a Control Moment Gyro (CMG) that is scheduled to fly on mission STS-114. The CMG will replace another on the International Space Station, which will require a spacewalk.

KSC-04pd1977

NASA Image and Video Library

2004-09-22

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, workers conduct a post-delivery verification test on a Control Moment Gyro (CMG) that is scheduled to fly on mission STS-114. The CMG will replace another on the International Space Station, which will require a spacewalk.

KSC-04pd1976

NASA Image and Video Library

2004-09-22

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, workers conduct a post-delivery verification test on a Control Moment Gyro (CMG) that is scheduled to fly on mission STS-114. The CMG will replace another on the International Space Station, which will require a spacewalk.

KPMG Peat Marwick LLP GreatLakes Composites Consortium, Inc. Fiscal Year Ended December 31, 1995

DTIC Science & Technology

1997-06-25

The objective of a quality control review is to assure that the audit was conducted in accordance with applicable standards and meets the auditing...requirements of the OMB Circular A-133. As the cognizant agency for the Institute, we conducted a quality control review of the audit working papers. We...focused our review on the qualitative aspects of the audit : due professional care, planning, supervision, independence, quality control, internal

Microwave quantum logic gates for trapped ions.

PubMed

Ospelkaus, C; Warring, U; Colombe, Y; Brown, K R; Amini, J M; Leibfried, D; Wineland, D J

2011-08-10

Control over physical systems at the quantum level is important in fields as diverse as metrology, information processing, simulation and chemistry. For trapped atomic ions, the quantized motional and internal degrees of freedom can be coherently manipulated with laser light. Similar control is difficult to achieve with radio-frequency or microwave radiation: the essential coupling between internal degrees of freedom and motion requires significant field changes over the extent of the atoms' motion, but such changes are negligible at these frequencies for freely propagating fields. An exception is in the near field of microwave currents in structures smaller than the free-space wavelength, where stronger gradients can be generated. Here we first manipulate coherently (on timescales of 20 nanoseconds) the internal quantum states of ions held in a microfabricated trap. The controlling magnetic fields are generated by microwave currents in electrodes that are integrated into the trap structure. We also generate entanglement between the internal degrees of freedom of two atoms with a gate operation suitable for general quantum computation; the entangled state has a fidelity of 0.76(3), where the uncertainty denotes standard error of the mean. Our approach, which involves integrating the quantum control mechanism into the trapping device in a scalable manner, could be applied to quantum information processing, simulation and spectroscopy.

Architecture of conference control functions

NASA Astrophysics Data System (ADS)

Kausar, Nadia; Crowcroft, Jon

1999-11-01

Conference control is an integral part in many-to-many communications that is used to manage and co-ordinate multiple users in conferences. There are different types of conferences which require different types of control. Some of the features of conference control may be user invoked while others are for internal management of a conference. In recent years, ITU (International Telecommunication Union) and IETF (Internet Engineering Task Force) have standardized two main models of conferencing, each system providing a set of conference control functionalities that are not easily provided in the other one. This paper analyzes the main activities appropriate for different types of conferences and presents an architecture for conference control called GCCP (Generic Conference Control Protocol). GCCP interworks different types of conferencing and provides a set of conference control functions that can be invoked by users directly. As an example of interworking, interoperation of IETF's SIP and ITU's H.323 call control functions have been examined here. This paper shows that a careful analysis of a conferencing architecture can provide a set of control functions essential for any group communication model that can be extensible if needed.

Senator Doug Jones (D-AL) Tour of MSFC Facilities

NASA Image and Video Library

2018-02-22

Senator Doug Jones (D-AL.) and wife, Louise, tour Marshall Space Flight facilities. Steve Doering, manager, Stages Element, Space Launch System (SLS) program at MSFC, also tour the Payload Operations Integration Center (POIC) where Marshall controllers oversee stowage requirements aboard the International Space Station (ISS) as well as scientific experiments. Different positions in the room are explained to Senator Jones by MSFC controller Beau Simpson.

Enhancing Command and Control (C2) Assessment through Semantic Systems

DTIC Science & Technology

2011-06-01

distribution unlimited 13. SUPPLEMENTARY NOTES Presented at the 16th International Command and Control Research and Technology Symposium (ICCRTS 2011...University Press, Washington, D.C., April 2008) 3 present complex contingencies that will require significant capabilities in which the power of the...cycle elements are not being brought forward and presented in ways that effectively frame and support good decisions that maximize achievement of

Perceived Health Locus of Control, Self-Esteem, and Its Relations to Psychological Well-Being Status in Iranian Students

PubMed Central

Moshki, M; Ashtarian, H

2010-01-01

Background: Health locus of control (HLC) has been associated with a variety of ailments and health outcomes and designed to predict behaviors and cognitive processes relevant to mental and physical health. This study investigated the relationships between perceived health locus of control, self-esteem, and mental health status among Iranian students. Methods: In this analytical study the subjects were recruited from students in Gonabad University of Medical Sciences, Iran, who studied in the first year (N=154). Students completed the questionnaires for assessing demographic, perceived health locus of control, self - esteem and psychological well- being data. Results: The statistical analysis revealed a negative relationship between perceived Internal HLC and self-esteem with psychological well-being. The positive correlation of the perceived Chance HLC with psychological well-being was statistically significant (r= 0.21, P< 0.01) and the positive correlation of the perceived Internal HLC with self-esteem was statistically significant (r= 0.25, P< 0.01). A significantly direct relationship between low perceived Internal HLC, self–esteem and psychological problems was found among these students. Conclusion: The findings will be addressed in relation to their implications for effective mental health education based on health locus of control especially internal and powerful others beliefs associated with self-esteem for students. This will require additional monitoring and uninterrupted trying in order to be effective. PMID:23113040

Guidelines for the detection of Trichinella larvae at the slaughterhouse in a quality assurance system.

PubMed

Rossi, Patrizia; Pozio, Edoardo

2008-01-01

The European Community Regulation (EC) No. 2075/2005 lays down specific rules on official controls for the detection of Trichinella in fresh meat for human consumption, recommending the pooled-sample digestion method as the reference method. The aim of this document is to provide specific guidance to implement an appropriate Trichinella digestion method by a laboratory accredited according to the ISO/IEC 17025:2005 international standard, and performing microbiological testing following the EA-04/10:2002 international guideline. Technical requirements for the correct implementation of the method, such as the personnel competence, specific equipments and reagents, validation of the method, reference materials, sampling, quality assurance of results and quality control of performance are provided, pointing out the critical control points for the correct implementation of the digestion method.

Anticipation from sensation: using anticipating synchronization to stabilize a system with inherent sensory delay.

PubMed

Eberle, Henry; Nasuto, Slawomir J; Hayashi, Yoshikatsu

2018-03-01

We present a novel way of using a dynamical model for predictive tracking control that can adapt to a wide range of delays without parameter update. This is achieved by incorporating the paradigm of anticipating synchronization (AS), where a 'slave' system predicts a 'master' via delayed self-feedback. By treating the delayed output of the plant as one half of a 'sensory' AS coupling, the plant and an internal dynamical model can be synchronized such that the plant consistently leads the target's motion. We use two simulated robotic systems with differing arrangements of the plant and internal model ('parallel' and 'serial') to demonstrate that this form of control adapts to a wide range of delays without requiring the parameters of the controller to be changed.

Translational regulation of sigma 32 synthesis: requirement for an internal control element.

PubMed Central

Kamath-Loeb, A S; Gross, C A

1991-01-01

We have investigated the sequence requirements for the translational regulation of sigma 32 by examining the behavior of a new rpoH-lacZ protein fusion containing a short N-terminal fragment of sigma 32 fused to beta-galactosidase. Although the fusion retains rpoH translational initiation signals, it lacks translational regulation, implicating coding sequences within rpoH in this regulatory process. Images PMID:2050641

Investigation of Inlet Control Parameters for an External-internal-compression Inlet from Mach 2.1 to 3.0

NASA Technical Reports Server (NTRS)

Anderson, B. H.; Bowditch, D. N.

1958-01-01

Investigation of the control parameters of an external-internal compression inlet indicates that the cowl-lip shock provides a signal to position the spike and to start the inlet over a Mach number range from 2.1 to 3.0. Use of a single fixed probe position to control the spike over the range of conditions resulted in a 3.7-count loss in total-pressure recovery at Mach 3.0 and 0 deg angle of attack. Three separate shock-sensing-probe positions were required to set the spike for peak recovery from Mach 2.1 to 3.0 and angles of attack from 0 deg to 6 deg. When the inlet was unstarted, an erroneous signal was obtained from the normal-shock control through most of the starting cycle that prevented the inlet from starting. Therefore, it was necessary to over-ride the normal-shock control signal and not allow the control to position the terminal shock until the spike was positioned.

Political economy of tobacco control in low-income and middle-income countries: lessons from Thailand and Zimbabwe. Global Analysis Project Team.

PubMed Central

Chantornvong, S.; Collin, J.; Dodgson, R.; Lee, K.; McCargo, D.; Seddon, D.; Vaughan, P.; Woelk, G.

2000-01-01

Crucial to the success of the proposed Framework Convention on Tobacco Control will be an understanding of the political and economic context for tobacco control policies, particularly in low-income and middle-income countries. Policy studies in Thailand and Zimbabwe employed the analytical perspective of political economy and a research strategy that used political mapping, a technique for characterizing and evaluating the political environment surrounding a policy issue, and stakeholder analysis, which seeks to identify key actors and to determine their capacity to shape policy outcomes. These policy studies clearly revealed how tobacco control in low-income and middle-income countries is also being shaped by developments in the global and regional political economy. Hence efforts to strengthen national control policies need to be set within the context of globalization and the international context. Besides the transnational tobacco companies, international tobacco groups and foreign governments, international agencies and nongovernmental organizations are also playing influential roles. It cannot be assumed, therefore, that the tobacco control strategies being implemented in industrialized countries will be just as effective and appropriate when implemented in developing countries. There is an urgent need to expand the number of such tobacco policy studies, particularly in low-income and middle-income countries. Comprehensive guidelines for tobacco policy analysis and research are required to support this process, as is a broader international strategy to coordinate further tobacco policy research studies at country, regional and global levels. PMID:10994265

Strengthening radiopharmacy practice in IAEA Member States.

PubMed

Duatti, Adriano; Bhonsle, Uday

2013-05-01

Radiopharmaceuticals are essential components of nuclear medicine procedures. Without radiopharmaceuticals nuclear medicine procedures cannot be performed. Therefore it could be said that 'No radiopharmaceutical-no nuclear medicine.' A good radiopharmacy practice supports nuclear medicine activities by producing radiopharmaceuticals that are safe and are of the required quality in a consistent way. As with any medicinal product, radiopharmaceuticals are required to be produced under carefully controlled conditions and are tested for their quality, prior to the administration to patients, using validated standard operating procedures. These procedures are based on the principles of Good Manufacturing Practice (GMP). The GMP principles are based on scientific knowledge and applicable regulatory requirements and guidance related to radiopharmaceutical productions and use. The International Atomic Energy Agency (IAEA) is committed to promote, in the Member States (MS), a rational and practical approach for the implementation of GMP for compounding or manufacturing of diagnostic or therapeutic radiopharmaceuticals. To pursue this goal the IAEA has developed various mechanisms and collaborations with individual experts in the field and with relevant national and international institutions or organizations. IAEA's activities in promoting radiopharmaceutical science include commissioning expert advice in the form of publications on radiopharmaceutical production, quality control and usage, producing technical guidance on production and regulatory aspects related to new radiopharmaceuticals, creating guidance documentation for self or internal audits of radiopharmaceutical production facilities, producing guidance on implementation of Quality Management System and GMP in radiopharmacy, assisting in creation of specific radiopharmaceutical monographs for the International Pharmacopoeia, and developing radiopharmacy-related human resource capabilities in MS through individual and regional training courses and education programs. IAEA strongly supports development of clinical nuclear medicine services by assisting MS in setting up reliable Radiopharmaceutical production facilities for single photon emission computed tomography, positron emission tomography, and for therapeutic applications. Copyright © 2013 Elsevier Inc. All rights reserved.

[Internal audit in medical laboratory: what means of control for an effective audit process?].

PubMed

Garcia-Hejl, Carine; Chianéa, Denis; Dedome, Emmanuel; Sanmartin, Nancy; Bugier, Sarah; Linard, Cyril; Foissaud, Vincent; Vest, Philippe

2013-01-01

To prepare the French Accreditation Committee (COFRAC) visit for initial certification of our medical laboratory, our direction evaluated its quality management system (QMS) and all its technical activities. This evaluation was performed owing an internal audit. This audit was outsourced. Auditors had an expertise in audit, a whole knowledge of biological standards and were independent. Several nonconformities were identified at that time, including a lack of control of several steps of the internal audit process. Hence, necessary corrective actions were taken in order to meet the requirements of standards, in particular, the formalization of all stages, from the audit program, to the implementation, review and follow-up of the corrective actions taken, and also the implementation of the resources needed to carry out audits in a pre-established timing. To ensure an optimum control of each step, the main concepts of risk management were applied: process approach, root cause analysis, effects and criticality analysis (FMECA). After a critical analysis of our practices, this methodology allowed us to define our "internal audit" process, then to formalize it and to follow it up, with a whole documentary system.

Zero-sum two-player game theoretic formulation of affine nonlinear discrete-time systems using neural networks.

PubMed

Mehraeen, Shahab; Dierks, Travis; Jagannathan, S; Crow, Mariesa L

2013-12-01

In this paper, the nearly optimal solution for discrete-time (DT) affine nonlinear control systems in the presence of partially unknown internal system dynamics and disturbances is considered. The approach is based on successive approximate solution of the Hamilton-Jacobi-Isaacs (HJI) equation, which appears in optimal control. Successive approximation approach for updating control and disturbance inputs for DT nonlinear affine systems are proposed. Moreover, sufficient conditions for the convergence of the approximate HJI solution to the saddle point are derived, and an iterative approach to approximate the HJI equation using a neural network (NN) is presented. Then, the requirement of full knowledge of the internal dynamics of the nonlinear DT system is relaxed by using a second NN online approximator. The result is a closed-loop optimal NN controller via offline learning. A numerical example is provided illustrating the effectiveness of the approach.

Defining contamination control requirements for non-human research on Space Station Freedom

NASA Technical Reports Server (NTRS)

Corbin, Barbara J.; Funk, Glenn A.

1992-01-01

The use of non-human biological specimens for life sciences research on Space Station Freedom has generated concerns about spacecraft internal contamination, crew safety and hardware utility. Various NASA organizations convened to discuss the concerns and determine how they should be addressed. This paper will present the issues raised at this meeting, the process by which safety concerns were identified, and the means by which contamination control requirements for all biological payloads were recommended for incorporation into Space Station Freedom safety requirements. The microbiological, toxicological and particulate contamination criteria for long-term spaceflight will be based on realistic assessment of risk and hardware will be designed to meet established contamination criteria while facilitating crew operations, thereby meeting the needs of the investigator.

MCST Research Operations | NREL

Science.gov Websites

Readiness. Laboratory Utilization. Custom Research Equipment Design-Build Capabilities. Add short description Concept and Design Design Requirements Assessment Controls and Automation Design-Build Services International (SEMI) S2 standard assessment Computer-Aided Design (CAD)/Piping and Instrumentation Diagram (P

13 CFR 130.330 - Operating requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... assessment and evaluation, and internal quality control. (c) The Lead Center shall be open to the public... provide administrative services and coordination for the SBDC network, including program development... Project Officer as soon as is feasible. Other SBDC service providers shall be open during the normal...

48 CFR 1646.201 - Contract Quality Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ensure that services acquired under the FEHB contract conform to the contract's quality and audit requirements. (b) OPM will periodically evaluate the contractor's system of internal controls under the quality... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract Quality Policy...

Proposed English Standards Promote Aviation Safety.

ERIC Educational Resources Information Center

Chatham, Robert L.; Thomas, Shelley

2000-01-01

Discusses the International Civil Aviation Organization's (ICAO) Air Navigation's Commission approval of a task to develop minimum skill level requirements in English for air traffic control. The ICAO collaborated with the Defense Language Institute English Language Center to propose a minimum standard for English proficiency for international…

19 CFR 19.13 - Requirements for establishment of warehouse.

Code of Federal Regulations, 2010 CFR

2010-04-01

...; DEPARTMENT OF THE TREASURY CUSTOMS WAREHOUSES, CONTAINER STATIONS AND CONTROL OF MERCHANDISE THEREIN... secured area separated from the remainder of the premises to be used exclusively for the storage of imported merchandise, domestic spirits, and merchandise subject to internal-revenue tax transferred into...

A Comprehensive Review of Spirit Drink Safety Standards and Regulations from an International Perspective.

PubMed

Pang, Xiao-Na; Li, Zhao-Jie; Chen, Jing-Yu; Gao, Li-Juan; Han, Bei-Zhong

2017-03-01

Standards and regulations related to spirit drinks have been established by different countries and international organizations to ensure the safety and quality of spirits. Here, we introduce the principles of food safety and quality standards for alcoholic beverages and then compare the key indicators used in the distinct standards of the Codex Alimentarius Commission, the European Union, the People's Republic of China, the United States, Canada, and Australia. We also discuss in detail the "maximum level" of the following main contaminants of spirit drinks: methanol, higher alcohols, ethyl carbamate, hydrocyanic acid, heavy metals, mycotoxins, phthalates, and aldehydes. Furthermore, the control measures used for potential hazards are introduced. Harmonization of the current requirements based on comprehensive scope analysis and the risk assessment approach will enhance both the trade and quality of distilled spirits. This review article provides valuable information that will enable producers, traders, governments, and researchers to increase their knowledge of spirit drink safety requirements, control measures, and research trends.

Toward a national health risk management approach in Australia.

PubMed

O'Donnell, Carol

2002-01-01

There has been increasing international consensus about the importance of competition for achieving national growth and community well-being. The Australian government accordingly has introduced policies to promote such competition. Major legislative review and many public inquiries have assisted implementation of national competition policy and the development of national goals and standards related to international agreements to promote health and sustainable development. Since the 1980s, Australia has had legislation that requires the identification and control of health risks arising at work. The management structures necessary for coordinated delivery of national programs designed for effective identification and control of health risks arising in communities to achieve national health and development goals are still being developed, however. Major difficulties related to this development are discussed. National health development programs should be approached primarily through establishment of regional partnerships between bodies responsible for managing community health, local government, and employment placement, in consultation with other relevant organizations and the community. Related research and evaluation programs are required.

Design of an optical lens combined with a total internal reflection (TIR) freeform surface for a LED front fog lamp

NASA Astrophysics Data System (ADS)

Wang, Hong; Li, Xiufeng; Ge, Peng

2017-02-01

We propose a design method of an optical lens combined with a total internal reflection (TIR) freeform surface for a LED front fog lamp. The TIR freeform surface controls the edge rays of the LED source. It totally reflects the edge rays and makes them emit from the top surface of the lens. And the middle rays of the LED source go through the refractive surface and reach the measured plane. We simulate the model by Monte Carlo method. Simulation results show that the front fog lamp system can satisfy the requirement of ECE R19 Rev7. The light control efficiency can reach up to 76%.

Cultural Challenges Faced by American Mission Control Personnel Working with International Partners

NASA Technical Reports Server (NTRS)

Clement, J. L.; Ritsher, J. B.

2006-01-01

Operating the International Space Station (ISS) involves an indefinite, continuous series of long-duration international missions, and this requires an unprecedented degree of cooperation across multiple sites, organizations, and nations. Both junior and senior mission control personnel have had to find ways to address the cultural challenges inherent in such work, but neither have had systematic training in how to do so. The goals of this study were to identify and evaluate the major cultural challenges faced by ISS mission control personnel and to highlight the approaches that they have found most effective to surmount these challenges. We pay particular attention to the approaches successfully employed by the senior personnel and the training needs identified by the junior personnel. We also evaluate the extent to which the identified approaches and needs are consistent across the two samples. METHODS: Participants included a sample of 14 senior ISS flight controllers and a contrasting sample of 12 more junior controllers. All participants were mission operations specialists chosen on the basis of having worked extensively with international partners. Data were collected using a semi-structured qualitative interview and content analyzed using an iterative process with multiple coders and consensus meetings to resolve discrepancies. RESULTS: The senior respondents had substantial consensus on several cultural challenges and on key strategies for dealing with them, and they offered a wide range of specific tactics for implementing these strategies. Data from the junior respondents will be presented for the first time at the meeting. DISCUSSION: Although specific to American ISS personnel, our results are consistent with recent management, cultural, and aerospace research on other populations. We aim to use our results to improve training for current and future mission control personnel working in international or multicultural mission operations teams.

Preparing for Serious Communicable Diseases in the United States: What the Ebola Virus Epidemic Has Taught Us.

PubMed

Varkey, Jay B; Ribner, Bruce S

2016-06-01

Ending the West Africa Ebola virus disease (EVD) outbreak required an unprecedented international response. For the United States, participation in the international response to the West Africa EVD outbreak provided an opportunity to learn important lessons in four key domains critical to preparing for future outbreaks of EVD and other serious communicable diseases: (i) safe and effective patient care, (ii) the role of experimental therapeutics and vaccines, (iii) infection control, and (iv) hospital and community preparedness.

Counterfactual thinking in patients with amnesia

PubMed Central

Mullally, Sinéad L; Maguire, Eleanor A

2014-01-01

We often engage in counterfactual (CF) thinking, which involves reflecting on “what might have been.” Creating alternative versions of reality seems to have parallels with recollecting the past and imagining the future in requiring the simulation of internally generated models of complex events. Given that episodic memory and imagining the future are impaired in patients with hippocampal damage and amnesia, we wondered whether successful CF thinking also depends upon the integrity of the hippocampus. Here using two nonepisodic CF thinking tasks, we found that patients with bilateral hippocampal damage and amnesia performed comparably with matched controls. They could deconstruct reality, add in and recombine elements, change relations between temporal sequences of events, enabling them to determine plausible alternatives of complex episodes. A difference between the patients and control participants was evident, however, in the patients' subtle avoidance of CF simulations that required the construction of an internal spatial representation. Overall, our findings suggest that mental simulation in the form of nonepisodic CF thinking does not seem to depend upon the hippocampus unless there is the added requirement for construction of a coherent spatial scene within which to play out scenarios. © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc. PMID:24978690

Counterfactual thinking in patients with amnesia.

PubMed

Mullally, Sinéad L; Maguire, Eleanor A

2014-11-01

We often engage in counterfactual (CF) thinking, which involves reflecting on "what might have been." Creating alternative versions of reality seems to have parallels with recollecting the past and imagining the future in requiring the simulation of internally generated models of complex events. Given that episodic memory and imagining the future are impaired in patients with hippocampal damage and amnesia, we wondered whether successful CF thinking also depends upon the integrity of the hippocampus. Here using two nonepisodic CF thinking tasks, we found that patients with bilateral hippocampal damage and amnesia performed comparably with matched controls. They could deconstruct reality, add in and recombine elements, change relations between temporal sequences of events, enabling them to determine plausible alternatives of complex episodes. A difference between the patients and control participants was evident, however, in the patients' subtle avoidance of CF simulations that required the construction of an internal spatial representation. Overall, our findings suggest that mental simulation in the form of nonepisodic CF thinking does not seem to depend upon the hippocampus unless there is the added requirement for construction of a coherent spatial scene within which to play out scenarios. Copyright © 2014 THE AUTHORS. HIPPOCAMPUS PUBLISHED BY WILEY PERIODICALS, INC.

International Aerospace and Ground Conference on Lightning and Static Electricity (8th): Lightning Technology Roundup, held at Fort Worth, Texas on 21-23 June 1983.

DTIC Science & Technology

1983-06-01

fighter aircraft. The entire test bed is from testing of a representative digital supported above the ground plane by non - control system(s)l e.g... control and Increased systems Integration a. Raw data must be collected and Introduce new requirements for protection, experimental setups and An accurate...presented, several possible solutions to the grounding prob! - are suggested. All rely on establishing initial ground contact through a controlled non -zero

Is Your Biobank Up to Standards? A Review of the National Canadian Tissue Repository Network Required Operational Practice Standards and the Controlled Documents of a Certified Biobank.

PubMed

Hartman, Victoria; Castillo-Pelayo, Tania; Babinszky, Sindy; Dee, Simon; Leblanc, Jodi; Matzke, Lise; O'Donoghue, Sheila; Carpenter, Jane; Carter, Candace; Rush, Amanda; Byrne, Jennifer; Barnes, Rebecca; Mes-Messons, Anne-Marie; Watson, Peter

2018-02-01

Ongoing quality management is an essential part of biobank operations and the creation of high quality biospecimen resources. Adhering to the standards of a national biobanking network is a way to reduce variability between individual biobank processes, resulting in cross biobank compatibility and more consistent support for health researchers. The Canadian Tissue Repository Network (CTRNet) implemented a set of required operational practices (ROPs) in 2011 and these serve as the standards and basis for the CTRNet biobank certification program. A review of these 13 ROPs covering 314 directives was conducted after 5 years to identify areas for revision and update, leading to changes to 7/314 directives (2.3%). A review of all internal controlled documents (including policies, standard operating procedures and guides, and forms for actions and processes) used by the BC Cancer Agency's Tumor Tissue Repository (BCCA-TTR) to conform to these ROPs was then conducted. Changes were made to 20/106 (19%) of BCCA-TTR documents. We conclude that a substantial fraction of internal controlled documents require updates at regular intervals to accommodate changes in best practices. Reviewing documentation is an essential aspect of keeping up to date with best practices and ensuring the quality of biospecimens and data managed by biobanks.

Evidence of motor-control difficulties in children with attention deficit hyperactivity disorder, explored through a hierarchical motor-systems perspective.

PubMed

Macoun, Sarah J; Kerns, Kimberly A

2016-01-01

Attention deficit hyperactivity disorder (ADHD) may reflect a disorder of neural systems that regulate motor control. The current study investigates motor dysfunction in children with ADHD using a hierarchical motor-systems perspective where frontal-striatal/"medial" brain systems are viewed as regulating parietal/"lateral" brain systems in a top down manner, to inhibit automatic environmentally driven responses in favor of goal-directed behavior. It was hypothesized that due to frontal-striatal hypoactivation, children with ADHD would have difficulty with higher order motor control tasks felt to be dependent on these systems, yet have preserved general motor function. A total of 63 children-ADHD and matched controls-completed experimental motor tasks that required maintenance of internal motor representations and the ability to inhibit visually driven responses. Children also completed a measure of motor inhibition, and a portion of the sample completed general motor function tasks. On motor tasks that required them to maintain internal motor representations and to inhibit automatic motor responses, children with ADHD had significantly greater difficulty than controls, yet on measures of general motor dexterity, their performance was comparable. Children with ADHD displayed significantly greater intraindividual (subject) variability than controls. Intraindividual variability (IIV) contributed to variations in performance across the motor tasks, but did not account for all of the variance on all tasks. These findings suggest that children with ADHD may be more controlled by external stimuli than by internally represented information, possibly due to dysfunction of the medial motor system. However, it is likely that children with ADHD also display general motor-execution problems (as evidenced by IIV findings), suggesting that atypicalities may extend to both medial and lateral motor systems. Findings are interpreted within the context of contemporary theories regarding motor dysfunction in ADHD, and implications for understanding externalizing behaviors in ADHD are discussed.

Improved Controls for Fusion RF Systems. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casey, Jeffrey A.

2011-11-08

We have addressed the specific requirements for the integrated systems controlling an array of klystrons used for Lower Hybrid Current Drive (LHCD). The immediate goal for our design was to modernize the transmitter protection system (TPS) for LHCD on the Alcator C-Mod tokamak at the MIT Plasma Science and Fusion Center (MIT-PSFC). Working with the Alcator C-Mod team, we have upgraded the design of these controls to retrofit for improvements in performance and safety, as well as to facilitate the upcoming expansion from 12 to 16 klystrons. The longer range goals to generalize the designs in such a way thatmore » they will be of benefit to other programs within the international fusion effort was met by designing a system which was flexible enough to address all the MIT system requirements, and modular enough to adapt to a large variety of other requirements with minimal reconfiguration.« less

Noise transmission and reduction in turboprop aircraft

NASA Astrophysics Data System (ADS)

MacMartin, Douglas G.; Basso, Gordon L.; Leigh, Barry

1994-09-01

There is considerable interest in reducing the cabin noise environment in turboprop aircraft. Various approaches have been considered at deHaviland Inc., including passive tuned-vibration absorbers, speaker-based noise cancellation, and structural vibration control of the fuselage. These approaches will be discussed briefly. In addition to controlling the noise, a method of predicting the internal noise is required both to evaluate potential noise reduction approaches, and to validate analytical design models. Instead of costly flight tests, or carrying out a ground simulation of the propeller pressure field, a much simpler reciprocal technique can be used. A capacitive scanner is used to measure the fuselage vibration response on a deHaviland Dash-8 fuselage, due to an internal noise source. The approach is validated by comparing this reciprocal noise transmission measurement with the direct measurement. The fuselage noise transmission information is then combined with computer predictions of the propeller pressure field data to predict the internal noise at two points.

Propellant Savings during Soyuz Undock from the International Space Station

NASA Technical Reports Server (NTRS)

Turett, Fiona

2016-01-01

As a vehicle continuously orbiting Earth for over a decade, the International Space Station (ISS) must be conscious of ways to conserve consumables to maximize the efficiency of cargo flights to ISS. One such consumable is propellant. As part of an ongoing effort to minimize propellant usage onboard ISS and use control moment gyroscopes as much as possible for ISS control, an effort was made in late 2014 to allow Soyuz manned vehicle undockings without requiring the use of thrusters. This method, which has been used for four Soyuz undockings, saves up to 160 kg of propellant each year. Fiona completed a B.S. is Mechanical Engienering at Washington University in St. Louis in 2009, after which she moved to Houston, TX to begin working at NASA Johnson Space Center. She currently works in the Flight Operations Directorate as an ADCO (Attitude Determination and Control Officer) flight controller and MCG (Motion Control Group) instructor. Her responsibilities include operating the motion control systems of the ISS in Mission Control, interfacing with Russian colleagues, mentoring and teaching flight controller trainees, and training astronauts for their missions to ISS.

15 CFR Supplement No. 1 to Part 730 - Information Collection Requirements Under the Paperwork Reduction Act: OMB Control Numbers

Code of Federal Regulations, 2010 CFR

2010-01-01

... Delivery Verification Certificate §§ 748.13 and 762.2(b). 0694-0017 International Import Certificate § 748... Procedure for Voluntary Self-Disclosure of Violations §§ 762.2(b) and 764.5. 0694-0073 Export Controls of... Iraq § 732.3, 738, 744.18, 746.3(b)(1), 747, 750, 758, 762, 772, 774. 0694-0132 Voluntary Self...

Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin.

PubMed

Smith, Thomas H; Li, Julia G; Dores, Michael R; Trejo, JoAnn

2017-08-18

Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4 (PAR4) has been shown to dimerize with the purinergic receptor P2Y12 to coordinate β-arrestin-mediated Akt signaling, an important mediator of integrin activation. However, the mechanism by which the PAR4-P2Y12 dimer controls β-arrestin-dependent Akt signaling is not known. We now report that PAR4 and P2Y12 heterodimer internalization is required for β-arrestin recruitment to endosomes and Akt signaling. Using bioluminescence resonance energy transfer, immunofluorescence microscopy, and co-immunoprecipitation in cells expressing receptors exogenously and endogenously, we demonstrate that PAR4 and P2Y12 specifically interact and form dimers expressed at the cell surface. We also found that activation of PAR4 but not of P2Y12 drives internalization of the PAR4-P2Y12 heterodimer. Remarkably, activated PAR4 internalization was required for recruitment of β-arrestin to endocytic vesicles, which was dependent on co-expression of P2Y12. Interestingly, stimulation of the PAR4-P2Y12 heterodimer promotes β-arrestin and Akt co-localization to intracellular vesicles. Moreover, activated PAR4-P2Y12 internalization is required for sustained Akt activation. Thus, internalization of the PAR4-P2Y12 heterodimer is necessary for β-arrestin recruitment to endosomes and Akt signaling and lays the foundation for examining whether blockade of PAR4 internalization reduces integrin and platelet activation. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Development of a 13 kW Hall Thruster Propulsion System Performance Model for AEPS

NASA Technical Reports Server (NTRS)

Stanley, Steven; Allen, May; Goodfellow, Keith; Chew, Gilbert; Rapetti, Ryan; Tofil, Todd; Herman, Dan; Jackson, Jerry; Myers, Roger

2017-01-01

The Advanced Electric Propulsion System (AEPS) program will develop a flight 13kW Hall thruster propulsion system based on NASA's HERMeS thruster. The AEPS system includes the Hall Thruster, the Power Processing Unit (PPU) and the Xenon Flow Controller (XFC). These three primary components must operate together to ensure that the system generates the required combinations of thrust and specific impulse at the required system efficiencies for the desired system lifetime. At the highest level, the AEPS system will be integrated into the spacecraft and will receive power, propellant, and commands from the spacecraft. Power and propellant flow rates will be determined by the throttle set points commanded by the spacecraft. Within the system, the major control loop is between the mass flow rate and thruster current, with time-dependencies required to handle all expected transients, and additional, much slower interactions between the thruster and cathode temperatures, flow controller and PPU. The internal system interactions generally occur on shorter timescales than the spacecraft interactions, though certain failure modes may require rapid responses from the spacecraft. The AEPS system performance model is designed to account for all these interactions in a way that allows evaluation of the sensitivity of the system to expected changes over the planned mission as well as to assess the impacts of normal component and assembly variability during the production phase of the program. This effort describes the plan for the system performance model development, correlation to NASA test data, and how the model will be used to evaluate the critical internal and external interactions. The results will ensure the component requirements do not unnecessarily drive the system cost or overly constrain the development program. Finally, the model will be available to quickly troubleshoot any future unforeseen development challenges.

U.S. Immigration Policy and the National Interest.

ERIC Educational Resources Information Center

Fauriol, Georges

1984-01-01

The national security of the United States depends upon its domestic strength and international stability. This strength requires an ability to control national borders, the maintenance of an independent foreign policy, a prosperous economy, and a cohesive domestic political environment. Uncontrolled migration is undermining this strength. (RM)

48 CFR 252.215-7002 - Cost estimating system requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... costs and other data included in proposals submitted to customers in the expectation of receiving... lines of authority, duties, and responsibilities; (3) Internal controls and managerial reviews; (4) Flow... Contractor shall, within 30 days, state its rationale for disagreeing. (2) The ACO will evaluate the...

42 CFR 422.4 - Types of MA plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... availability, service area, and quality. (ii) Coordinated care plans may include mechanisms to control... requirements of sections 138 and 220 of the Internal Revenue Code. (3) MA private fee-for-service plan. An MA... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

13 CFR 120.1050 - On-site reviews and examinations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... operations management; (3) Credit administration; and (4) Compliance with Loan Program Requirements. (b) On... reviews. SBA may conduct on-site reviews of the SBA loan operations of SBA Lenders. The on-site review may... losses); (3) Management quality (including internal controls, loan portfolio management, and asset...

48 CFR 17.703 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policy. 17.703 Section 17... Behalf of the Department of Defense 17.703 Policy. (a) A DoD acquisition official may request a... applicable procurement requirements if the procurement policies, procedures, and internal controls of the...

25 CFR 543.18 - What are the minimum internal control standards for the cage, vault, kiosk, cash and cash...

Code of Federal Regulations, 2014 CFR

2014-04-01

... available upon demand for each day, shift, and drop cycle (this is not required if the system does not track..., beverage containers, etc., into and out of the cage. (j) Variances. The operation must establish, as...

25 CFR 543.18 - What are the minimum internal control standards for the cage, vault, kiosk, cash and cash...

Code of Federal Regulations, 2013 CFR

2013-04-01

... available upon demand for each day, shift, and drop cycle (this is not required if the system does not track..., beverage containers, etc., into and out of the cage. (j) Variances. The operation must establish, as...

[Implementation of quality standard UNE-EN ISO/IEC 17043 in the External Quality Control Program of the Spanish Society of Infectious Diseases and Clinical Microbiology].

PubMed

Poveda Gabaldón, Marta; Ovies, María Rosario; Orta Mira, Nieves; Serrano, M del Remedio Guna; Avila, Javier; Giménez, Alicia; Cardona, Concepción Gimeno

2011-12-01

The quality standard "UNE-EN-ISO 17043: 2010. Conformity assessment. General requirements for proficiency testing" applies to centers that organize intercomparisons in all areas. In the case of clinical microbiology laboratories, these intercomparisons must meet the management and technical standards required to achieve maximum quality in the performance of microbiological analysis and the preparation of test items (sample, product, data or other information used in the proficiency test) to enable them to be accredited. Once accredited, these laboratories can operate as a tool for quality control laboratories and competency assessment. In Spain, accreditation is granted by the Spanish Accreditation Body [Entidad Nacional de Acreditación (ENAC)]. The objective of this review is to explain how to apply the requirements of the standard to laboratories providing intercomparisons in the field of clinical microbiology (the organization responsible for all the tasks related to the development and operation of a proficiency testing program). This requires defining the scope and specifying the technical requirements (personnel management, control of equipment, facilities and environment, the design of the proficiency testing and data analysis for performance evaluation, communication with participants and confidentiality) and management requirements (document control, purchasing control, monitoring of complaints / claims, non-compliance, internal audits and management reviews). Copyright © 2011 Elsevier España S.L. All rights reserved.

International Space Station Program Phase 3 Integrated Atmosphere Revitalization Subsystem Test

NASA Technical Reports Server (NTRS)

Perry, J. L.; Franks, G. D.; Knox, J. C.

1997-01-01

Testing of the International Space Station (ISS) U.S. Segment baseline configuration of the Atmosphere Revitalization Subsystem (ARS) by NASA's Marshall Space Flight Center (MSFC) was conducted as part of the Environmental Control and Life Support System (ECLSS) design and development program. This testing was designed to answer specific questions regarding the control and performance of the baseline ARS subassemblies in the ISS U.S. Segment configuration. These questions resulted from the continued maturation of the ISS ECLSS configuration and design requirement changes since 1992. The test used pressurized oxygen injection, a mass spectrometric major constituent analyzer, a Four-Bed Molecular Sieve Carbon Dioxide Removal Assembly, and a Trace Contaminant Control Subassembly to maintain the atmospheric composition in a sealed chamber at ISS specifications for 30 days. Human metabolic processes for a crew of four were simulated according to projected ISS mission time lines. The performance of a static feed water electrolysis Oxygen Generator Assembly was investigated during the test preparation phases; however, technical difficulties prevented its use during the integrated test. The Integrated ARS Test (IART) program built upon previous closed-door and open-door integrated testing conducted at MSFC between 1987 and 1992. It is the most advanced test of an integrated ARS conducted by NASA to demonstrate its end-to-end control and overall performance. IART test objectives, facility design, pretest analyses, test and control requirements, and test results are presented.

Priorities in the prevention and control of multidrug-resistant Enterobacteriaceae in hospitals.

PubMed

Khan, A S; Dancer, S J; Humphreys, H

2012-10-01

Multidrug-resistant Enterobacteriaceae (MDE) are a major public health threat due to international spread and few options for treatment. Furthermore, unlike meticillin-resistant Staphylococcus aureus (MRSA), MDE encompass several genera and multiple resistance mechanisms, including extended-spectrum beta-lactamases and carbapenemases, which complicate detection in the routine diagnostic laboratory. Current measures to contain spread in many hospitals are somewhat ad hoc as there are no formal national or international guidelines. We sought to establish what should be the priorities for the prevention and control of MDE and what is feasible for implementation. We also identify areas for further research. We reviewed the published literature and other sources e.g. national agencies, for measures and interventions used to control MDE. Certain categories of at risk patients should be screened, especially in critical care areas, using appropriate laboratory methods. Standard and contact precautions are essential and hand hygiene compliance requires continued emphasis and high compliance levels. As MDE may persist on environmental surfaces for weeks, environmental decontamination could also be an effective control intervention. There are limited options for decolonisation with inadequate studies to date and antibiotic stewardship within and outside the hospital remains important. As there is a clear deficit in the evidence base to infor guidance on prevention and control, research in key areas, such as rapid detection, is urgently required. Copyright © 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

[Health threats and health system crises. An approach to early warning and response. 2008 SESPAS Report].

PubMed

Simón Soria, Fernando; Guillén Enríquez, Francisco Javier

2008-04-01

The world is changing more and faster than ever before. New diseases are coming to light each year, controlled diseases are reemerging as potential threats, and natural or man-made disasters are increasingly affecting human health. The "International Health Regulations (2005)" reflect the changes in the response of public health to this new situation. Surveillance of specific diseases and predefined control measures have been replaced by surveillance of public health events of international concern and control measures adapted to each situation. The public health events of international interest are characterized by their seriousness, predictability, the risk of international spread and potential for travel or trade restrictions. The development of the European Early Warning and Response System in 1998 and the creation of the European Center for Disease Prevention and Control in 2005 demonstrate political commitment in Europe, with early detection of and response to public health threats. However, timely risk evaluation and response at a national level requires improved data digitalization and accessibility, automatic notification processes, data analysis and dissemination of information, the combination of information from multiple sources and adaptation of public health services. The autonomous regions in Spain are initiating this adaptation process, but interoperability between systems and the development of guidelines for a coordinated response should be steered by the National Interregional Health Council and coordinated by the Ministry of Health. Efficient early warning systems of health threats that allow for a timely response and reduce uncertainty about information would help to minimize the risk of public health crises. The profile of public health threats is nonspecific. Early detection of threats requires access to information from multiple sources and efficient risk assessment. Key factors for improving the response to public health threats are the development of surveillance methods and operational research in public health.

Anticipation from sensation: using anticipating synchronization to stabilize a system with inherent sensory delay

PubMed Central

Nasuto, Slawomir J.; Hayashi, Yoshikatsu

2018-01-01

We present a novel way of using a dynamical model for predictive tracking control that can adapt to a wide range of delays without parameter update. This is achieved by incorporating the paradigm of anticipating synchronization (AS), where a ‘slave’ system predicts a ‘master’ via delayed self-feedback. By treating the delayed output of the plant as one half of a ‘sensory’ AS coupling, the plant and an internal dynamical model can be synchronized such that the plant consistently leads the target’s motion. We use two simulated robotic systems with differing arrangements of the plant and internal model (‘parallel’ and ‘serial’) to demonstrate that this form of control adapts to a wide range of delays without requiring the parameters of the controller to be changed. PMID:29657750

The effect of a clinical medical librarian on in-patient care outcomes.

PubMed

Esparza, Julia M; Shi, Runhua; McLarty, Jerry; Comegys, Marianne; Banks, Daniel E

2013-07-01

The research sought to determine the effect of a clinical medical librarian (CML) on outcomes of in-patients on the internal medicine service. A prospective study was performed with two internal medicine in-patient teams. Team 1 included a CML who accompanied the team on daily rounds. The CML answered questions posed at the point of care immediately or in emails post-rounds. Patients on Team 2, which did not include a CML, as well as patients who did not require consultation by the CML on Team 1, served as the control population. Numerous clinical and library metrics were gathered on each question. Patients on Team 1 who required an answer to a clinical question were more ill and had a longer length of stay, higher costs, and higher readmission rates compared to those in the control group. Using a matched pair analysis, we showed no difference in clinical outcomes between the intervention group and the control group. This study is the largest attempt to prospectively measure changes in patient outcomes when physicians were accompanied by a CML on rounds. This approach may serve as a model for further studies to define when and how CMLs are most effective.

Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1

PubMed Central

Kang, Yuan-Lin; Yochem, John; Bell, Leslie; Sorensen, Erika B.; Chen, Lihsia; Conner, Sean D.

2013-01-01

Low-density lipoprotein receptor (LDLR) internalization clears cholesterol-laden LDL particles from circulation in humans. Defects in clathrin-dependent LDLR endocytosis promote elevated serum cholesterol levels and can lead to atherosclerosis. However, our understanding of the mechanisms that control LDLR uptake remains incomplete. To identify factors critical to LDLR uptake, we pursued a genome-wide RNA interference screen using Caenorhabditis elegans LRP-1/megalin as a model for LDLR transport. In doing so, we discovered an unanticipated requirement for the clathrin-binding endocytic adaptor epsin1 in LDLR endocytosis. Epsin1 depletion reduced LDLR internalization rates in mammalian cells, similar to the reduction observed following clathrin depletion. Genetic and biochemical analyses of epsin in C. elegans and mammalian cells uncovered a requirement for the ubiquitin-interaction motif (UIM) as critical for receptor transport. As the epsin UIM promotes the internalization of some ubiquitinated receptors, we predicted LDLR ubiquitination as necessary for endocytosis. However, engineered ubiquitination-impaired LDLR mutants showed modest internalization defects that were further enhanced with epsin1 depletion, demonstrating epsin1-mediated LDLR endocytosis is independent of receptor ubiquitination. Finally, we provide evidence that epsin1-mediated LDLR uptake occurs independently of either of the two documented internalization motifs (FxNPxY or HIC) encoded within the LDLR cytoplasmic tail, indicating an additional internalization mechanism for LDLR. PMID:23242996

Integrating Space Flight Resource Management Skills into Technical Lessons for International Space Station Flight Controller Training

NASA Technical Reports Server (NTRS)

Baldwin, Evelyn

2008-01-01

The Johnson Space Center s (JSC) International Space Station (ISS) Space Flight Resource Management (SFRM) training program is designed to teach the team skills required to be an effective flight controller. It was adapted from the SFRM training given to Shuttle flight controllers to fit the needs of a "24 hours a day/365 days a year" flight controller. More recently, the length reduction of technical training flows for ISS flight controllers impacted the number of opportunities for fully integrated team scenario based training, where most SFRM training occurred. Thus, the ISS SFRM training program is evolving yet again, using a new approach of teaching and evaluating SFRM alongside of technical materials. Because there are very few models in other industries that have successfully tied team and technical skills together, challenges are arising. Despite this, the Mission Operations Directorate of NASA s JSC is committed to implementing this integrated training approach because of the anticipated benefits.

Meeting the requirements of importing countries: practice and policy for on-farm approaches to food safety.

PubMed

Dagg, P J; Butler, R J; Murray, J G; Biddle, R R

2006-08-01

In light of the increasing consumer demand for safe, high-quality food and recent public health concerns about food-borne illness, governments and agricultural industries are under pressure to provide comprehensive food safety policies and programmes consistent with international best practice. Countries that export food commodities derived from livestock must meet both the requirements of the importing country and domestic standards. It is internationally accepted that end-product quality control, and similar methods aimed at ensuring food safety, cannot adequately ensure the safety of the final product. To achieve an acceptable level of food safety, governments and the agricultural industry must work collaboratively to provide quality assurance systems, based on sound risk management principles, throughout the food supply chain. Quality assurance systems on livestock farms, as in other parts of the food supply chain, should address food safety using hazard analysis critical control point principles. These systems should target areas including biosecurity, disease monitoring and reporting, feedstuff safety, the safe use of agricultural and veterinary chemicals, the control of potential food-borne pathogens and traceability. They should also be supported by accredited training programmes, which award certification on completion, and auditing programmes to ensure that both local and internationally recognised guidelines and standards continue to be met. This paper discusses the development of policies for on-farm food safety measures and their practical implementation in the context of quality assurance programmes, using the Australian beef industry as a case study.

Funding for malaria control 2006-2010: a comprehensive global assessment.

PubMed

Pigott, David M; Atun, Rifat; Moyes, Catherine L; Hay, Simon I; Gething, Peter W

2012-07-28

The last decade has seen a dramatic increase in international and domestic funding for malaria control, coupled with important declines in malaria incidence and mortality in some regions of the world. As the ongoing climate of financial uncertainty places strains on investment in global health, there is an increasing need to audit the origin, recipients and geographical distribution of funding for malaria control relative to populations at risk of the disease. A comprehensive review of malaria control funding from international donors, bilateral sources and national governments was undertaken to reconstruct total funding by country for each year 2006 to 2010. Regions at risk from Plasmodium falciparum and/or Plasmodium vivax transmission were identified using global risk maps for 2010 and funding was assessed relative to populations at risk. Those nations with unequal funding relative to a regional average were identified and potential explanations highlighted, such as differences in national policies, government inaction or donor neglect. US$8.9 billion was disbursed for malaria control and elimination programmes over the study period. Africa had the largest levels of funding per capita-at-risk, with most nations supported primarily by international aid. Countries of the Americas, in contrast, were supported typically through national government funding. Disbursements and government funding in Asia were far lower with a large variation in funding patterns. Nations with relatively high and low levels of funding are discussed. Global funding for malaria control is substantially less than required. Inequity in funding is pronounced in some regions particularly when considering the distinct goals of malaria control and malaria elimination. Efforts to sustain and increase international investment in malaria control should be informed by evidence-based assessment of funding equity.

Funding for malaria control 2006–2010: A comprehensive global assessment

PubMed Central

2012-01-01

Background The last decade has seen a dramatic increase in international and domestic funding for malaria control, coupled with important declines in malaria incidence and mortality in some regions of the world. As the ongoing climate of financial uncertainty places strains on investment in global health, there is an increasing need to audit the origin, recipients and geographical distribution of funding for malaria control relative to populations at risk of the disease. Methods A comprehensive review of malaria control funding from international donors, bilateral sources and national governments was undertaken to reconstruct total funding by country for each year 2006 to 2010. Regions at risk from Plasmodium falciparum and/or Plasmodium vivax transmission were identified using global risk maps for 2010 and funding was assessed relative to populations at risk. Those nations with unequal funding relative to a regional average were identified and potential explanations highlighted, such as differences in national policies, government inaction or donor neglect. Results US$8.9 billion was disbursed for malaria control and elimination programmes over the study period. Africa had the largest levels of funding per capita-at-risk, with most nations supported primarily by international aid. Countries of the Americas, in contrast, were supported typically through national government funding. Disbursements and government funding in Asia were far lower with a large variation in funding patterns. Nations with relatively high and low levels of funding are discussed. Conclusions Global funding for malaria control is substantially less than required. Inequity in funding is pronounced in some regions particularly when considering the distinct goals of malaria control and malaria elimination. Efforts to sustain and increase international investment in malaria control should be informed by evidence-based assessment of funding equity. PMID:22839432

Legal and security requirements for the air transportation of cyanotoxins and toxigenic cyanobacterial cells for legitimate research and analytical purposes.

PubMed

Metcalf, J S; Meriluoto, J A O; Codd, G A

2006-05-25

Cyanotoxins are now recognised by international and national health and environment agencies as significant health hazards. These toxins, and the cells which produce them, are also vulnerable to exploitation for illegitimate purposes. Cyanotoxins are increasingly being subjected to national and international guidelines and regulations governing their production, storage, packaging and transportation. In all of these respects, cyanotoxins are coming under the types of controls imposed on a wide range of chemicals and other biotoxins of microbial, plant and animal origin. These controls apply whether cyanotoxins are supplied on a commercial basis, or stored and transported in non-commercial research collaborations and programmes. Included are requirements concerning the transportation of these toxins as documented by the United Nations, the International Air Transport Association (IATA) and national government regulations. The transportation regulations for "dangerous goods", which by definition include cyanotoxins, cover air mail, air freight, and goods checked in and carried on flights. Substances include those of determined toxicity and others of suspected or undetermined toxicity, covering purified cyanotoxins, cyanotoxin-producing laboratory strains and environmental samples of cyanobacteria. Implications of the regulations for the packaging and air-transport of dangerous goods, as they apply to cyanotoxins and toxigenic cyanobacteria, are discussed.

International Health Regulations (2005) facilitate communication for in-flight contacts of a Middle East respiratory syndrome case, Hong Kong Special Administrative Region, 2014.

PubMed

Kwok-ming, Poon; Miu-ling, Wong; Yiu-hong, Leung; Ka-wai, Sin; Liza, To May-kei; Shuk-kwan, Chuang

2015-01-01

The International Health Regulations (IHR) (2005) require World Health Organization Member States to notify events fulfilling two of four criteria: (1) serious public health impact; (2) unusual or unexpected event; (3) significant risk of international spread; or (4) significant risk of international travel or trade restrictions. (1) In-flight transmission of infections like severe acute respiratory syndrome is well documented. (2) With the enormous amount of air travel today, the risk of increasing in-flight transmission and subsequent international spread of infections are increasing. Prompt notification and information sharing under the IHR mechanism is critical for effective contact tracing and prompt control measures. We report on a case of in-flight exposure to an infection with significant public health risks that was successfully resolved using IHR (2005) guidelines.

Training Manual for Elements of Interface Definition and Control

NASA Technical Reports Server (NTRS)

Lalli, Vincent R. (Editor); Kastner, Robert E. (Editor); Hartt, Henry N. (Editor)

1997-01-01

The primary thrust of this manual is to ensure that the format and information needed to control interfaces between equipment are clear and understandable. The emphasis is on controlling the engineering design of the interface and not on the functional performance requirements of the system or the internal workings of the interfacing equipment. Interface control should take place, with rare exception, at the interfacing elements and no further. There are two essential sections of the manual. Chapter 2, Principles of Interface Control, discusses how interfaces are defined. It describes different types of interfaces to be considered and recommends a format for the documentation necessary for adequate interface control. Chapter 3, The Process: Through the Design Phases, provides tailored guidance for interface definition and control. This manual can be used to improve planned or existing interface control processes during system design and development. It can also be used to refresh and update the corporate knowledge base. The information presented herein will reduce the amount of paper and data required in interface definition and control processes by as much as 50 percent and will shorten the time required to prepare an interface control document. It also highlights the essential technical parameters that ensure that flight subsystems will indeed fit together and function as intended after assembly and checkout.

Pain as an indication for rib fixation: a bi-institutional pilot study.

PubMed

de Moya, Marc; Bramos, Thanos; Agarwal, Suresh; Fikry, Karim; Janjua, Sumbal; King, David R; Alam, Hasan B; Velmahos, George C; Burke, Peter; Tobler, William

2011-12-01

In trauma patients, open reduction and internal fixation of rib fractures remain controversial. We hypothesized that patients who have open reduction and internal fixation of rib fractures would experience less pain compared with controls and thus require fewer opiates. Further, we hypothesized that improved pain control would result in fewer pulmonary complications and decreased length of stay. This is a retrospective bi-institutional matched case-control study. Cases were matched 1:2 by age, injury severity Score, chest abbreviated injury severity score, head abbreviated injury severity score, pulmonary contusion score, and number of fractured ribs. The daily total doses of analgesic drugs were converted to equianalgesic intravenous morphine doses, and the primary outcome was inpatient narcotic administration. Sixteen patients between July 2005 and June 2009 underwent rib fixation in 5 ± 3 days after injury using an average of 3 (1-5) metallic plates. Morphine requirements decreased from 110 mg ± 98 mg preoperatively to 63 ± 57 mg postoperatively (p = 0.01). There were no significant differences between cases and controls in the mean morphine dose (79 ± 63 vs. 76 ± 55 mg, p = 0.65), hospital stay (18 ± 12 vs. 16 ± 11 days, p = 0.67), intensive care unit stay (9 ± 8 vs. 7 ± 10 days, p = 0.75), ventilation days (7 ± 8 vs. 6 ± 10, p = 0.44), and pneumonia rates (31% vs. 38%, p = 0.76). The need for analgesia was significantly reduced after rib fixation in patients with multiple rib fractures. However, no difference in outcomes was observed when these patients were compared with matched controls in this pilot study. Further study is required to investigate these preliminary findings.

The On-Line Audit Revisited: Yale University.

ERIC Educational Resources Information Center

Weldon, Albert R., Jr.; And Others

1984-01-01

Yale University's on-line examination of accounting and administrative systems is discussed. Program goals are to review financial management systems at the university to identify weaknesses in internal controls, and to fulfill all audit requirements of federal grants and contracts. After outlining the quarterly audit cycle, advantages of the…

78 FR 76187 - 30-Day Notice of Proposed Information Collection: Exchange Programs Alumni Web Site Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-16

...: Exchange Programs Alumni Web Site Registration ACTION: Notice of request for public comment and submission... Information Collection: Exchange Programs Alumni Web site Registration. OMB Control Number: 1405-0192. Type of... proposed collection: The International Exchange Alumni Web site requires information to process users...

Technique and interpretation in tree seed radiography

Treesearch

Howard B. Kriebel

1966-01-01

The study of internal seed structure by radiography requires techniques which will give good definition. To establish the best procedures, we conducted a series of experiments in which we manipulated the principal controllable variables affecting the quality of X-radiographs: namely, focus-to-film distance, film speed (grain), exposure time, kilovoltage, and...

78 FR 63219 - International Conference on Harmonisation; Draft Guidance on Elemental Impurities; Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-23

... appropriate limits for impurities, and emphasizes control of supply chains and risk assessments. It is... expectations for test requirements and regulatory filings, and a global policy for limiting elemental... written comments to the Division of Dockets Management (HFA-305), Food and Drug Administration, 5630...

76 FR 59024 - Federal Government Participation in the Automated Clearing House

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-23

... Act of 2008, account-related information could be shared only for certain types of benefit [[Page... international payment transactions using a new Standard Entry Class Code and to include certain information in... Control (OFAC). In addition, the rule requires financial institutions to provide limited account-related...

49 CFR 192.490 - Direct assessment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.490 Direct.... Threat Standard 1 External corrosion § 192.925 2 Internal corrosion in pipelines that transport dry gas § 192.927 Stress corrosion cracking § 192.929 1 For lines not subject to subpart O of this part, the...

49 CFR 192.490 - Direct assessment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.490 Direct.... Threat Standard 1 External corrosion § 192.925 2 Internal corrosion in pipelines that transport dry gas § 192.927 Stress corrosion cracking § 192.929 1 For lines not subject to subpart O of this part, the...

49 CFR 192.490 - Direct assessment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.490 Direct.... Threat Standard 1 External corrosion § 192.925 2 Internal corrosion in pipelines that transport dry gas § 192.927 Stress corrosion cracking § 192.929 1 For lines not subject to subpart O of this part, the...

49 CFR 192.490 - Direct assessment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.490 Direct.... Threat Standard 1 External corrosion § 192.925 2 Internal corrosion in pipelines that transport dry gas § 192.927 Stress corrosion cracking § 192.929 1 For lines not subject to subpart O of this part, the...

40 CFR 124.56 - Fact sheets.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Limitations to control toxic pollutants under § 122.44(e) of this chapter; (ii) Limitations on internal waste... specific effluent limitations and conditions or standards for sewage sludge use or disposal, including a... sludge use or disposal as required by § 122.44 and reasons why they are applicable or an explanation of...

40 CFR 124.56 - Fact sheets.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Limitations to control toxic pollutants under § 122.44(e) of this chapter; (ii) Limitations on internal waste... specific effluent limitations and conditions or standards for sewage sludge use or disposal, including a... sludge use or disposal as required by § 122.44 and reasons why they are applicable or an explanation of...

Report: New Hampshire Clean Water State Revolving Fund Program Financial Statements with Independent Auditor’s Report, June 30, 2002

EPA Pesticide Factsheets

Report #2003-1-00086, March 26, 2003. The audit contains reports on the financial statements, internal controls, and compliance requirements applicable to the Clean Water State Revolving Fund program in New Hampshire for the year ended June 30, 2002.

25 CFR 542.15 - What are the minimum internal control standards for credit?

Code of Federal Regulations, 2014 CFR

2014-04-01

...) Documentation of authorization by a person designated by management to approve credit limits; and (v) Credit... approved by personnel designated by management. (4) Proper approval of credit extensions over ten percent... that require access and are so authorized by management; (ii) Outstanding credit instruments shall be...

25 CFR 542.15 - What are the minimum internal control standards for credit?

Code of Federal Regulations, 2013 CFR

2013-04-01

...) Documentation of authorization by a person designated by management to approve credit limits; and (v) Credit... approved by personnel designated by management. (4) Proper approval of credit extensions over ten percent... that require access and are so authorized by management; (ii) Outstanding credit instruments shall be...

25 CFR 542.15 - What are the minimum internal control standards for credit?

Code of Federal Regulations, 2012 CFR

2012-04-01

...) Documentation of authorization by a person designated by management to approve credit limits; and (v) Credit... approved by personnel designated by management. (4) Proper approval of credit extensions over ten percent... that require access and are so authorized by management; (ii) Outstanding credit instruments shall be...

25 CFR 542.15 - What are the minimum internal control standards for credit?

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Documentation of authorization by a person designated by management to approve credit limits; and (v) Credit... approved by personnel designated by management. (4) Proper approval of credit extensions over ten percent... that require access and are so authorized by management; (ii) Outstanding credit instruments shall be...

25 CFR 542.15 - What are the minimum internal control standards for credit?

Code of Federal Regulations, 2011 CFR

2011-04-01

...) Documentation of authorization by a person designated by management to approve credit limits; and (v) Credit... approved by personnel designated by management. (4) Proper approval of credit extensions over ten percent... that require access and are so authorized by management; (ii) Outstanding credit instruments shall be...

Senator Doug Jones (D-AL) Tour of MSFC Facilities

NASA Image and Video Library

2018-02-22

Senator Doug Jones (D-AL.) and wife, Louise, tour Marshall Space Flight facilities. Steve Doering, manager, Stages Element, Space Launch System (SLS) program at MSFC, also tour the Payload Operations Integration Center (POIC) where Marshall controllers oversee stowage requirements aboard the International Space Station (ISS) as well as scientific experiments.

Salmonella Enteritidis deposition in eggs after experimental infection of laying hens with different oral doses

USDA-ARS?s Scientific Manuscript database

The continuing attribution of human Salmonella Enteritidis (SE) infections to internally contaminated eggs has necessitated the commitment of substantial public and private resources to SE testing and control programs in commercial laying flocks. Cost-effective risk reduction requires a detailed and...

78 FR 73128 - Dividend Equivalents From Sources Within the United States

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-05

... Dividend Equivalents From Sources Within the United States AGENCY: Internal Revenue Service (IRS), Treasury... dividends, and the amount of the dividend equivalents. This information is required to establish whether a... valid control number assigned by the Office of Management and Budget. Books or records relating to a...

49 CFR 192.490 - Direct assessment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Requirements for Corrosion Control § 192.490 Direct.... Threat Standard 1 External corrosion § 192.925 2 Internal corrosion in pipelines that transport dry gas § 192.927 Stress corrosion cracking § 192.929 1 For lines not subject to subpart O of this part, the...

Magnetic Resonance Imaging With Cochlear Implant Magnet in Place: Safety and Imaging Quality.

PubMed

Carlson, Matthew L; Neff, Brian A; Link, Michael J; Lane, John I; Watson, Robert E; McGee, Kiaran P; Bernstein, Matt A; Driscoll, Colin L W

2015-07-01

To evaluate the safety and image quality of 1.5-T MRI in patients with cochlear implants and retained internal magnets. Retrospective case series from 2012 to 2014. Single tertiary academic referral center. All cochlear implant recipients undergoing 1.5-T MRI without internal magnet removal. MRI after tight headwrap application. Patient tolerance, complications, and characteristics of imaging artifact. Nineteen ears underwent a total of 34 MRI scans. Two patients did not tolerate imaging with the headwrap in place and required magnet removal before rescanning. One subject experienced two separate episodes of polarity reversal in the same device from physical realignment (i.e., flipping) of the internal magnet requiring surgical repositioning. Three patients were discovered to have canting of the internal magnet after imaging. In all three cases, the magnet could be reseated by applying gentle firm pressure to the scalp until the magnet "popped" back into place. These patients continue to use their device without difficulty and have not required surgical replacement. In patients receiving head MRI, the ipsilateral internal auditory canal and cerebellopontine angle could be visualized without difficulty in 94% of cases. There were no episodes of cochlear implant device failure or soft tissue complications. Under controlled conditions, 1.5-T MRI can be successfully performed in most patients without the need for cochlear implant magnet removal. In nearly all cases, imaging artifact does not impede evaluation of the ipsilateral skull base. Patients should be counseled regarding the risk of internal magnet movement that may occur in up to 15% of cases, even with tight headwrap application. If internal magnet polarity reversal occurs, a trial of reversing the external magnet can be considered. If canting or mild displacement of the internal magnet occurs, an attempt at reseating can be made by applying gentle firm pressure to the scalp over the internal magnet. If conservative measures fail, the magnet should be surgically repositioned to minimize interruption of device use and to prevent scalp complications.

Variable Speed CMG Control of a Dual-Spin Stabilized Unconventional VTOL Air Vehicle

NASA Technical Reports Server (NTRS)

Lim, Kyong B.; Moerder, Daniel D.; Shin, J-Y.

2004-01-01

This paper describes an approach based on using both bias momentum and multiple control moment gyros for controlling the attitude of statically unstable thrust-levitated vehicles in hover or slow translation. The stabilization approach described in this paper uses these internal angular momentum transfer devices for stability, augmented by thrust vectoring for trim and other outer loop control functions, including CMG stabilization/ desaturation under persistent external disturbances. Simulation results show the feasibility of (1) improved vehicle performance beyond bias momentum assisted vector thrusting control, and (2) using control moment gyros to significantly reduce the external torque required from the vector thrusting machinery.

[Trans-anal disarterization of internal hemorrhoids under Doppler control with mucopexy and lifting in treatment of stage III-IV hemorrhoids].

PubMed

Zagriadskiĭ, E A

2009-01-01

85 patients at age of 27-68 years (44.78+/-9.02) with stage III-IV hemorrhoids were treated. Trans-anal disarterization of internal hemorrhoids under Doppler control with mucopexy and lifting was carried out using modified Moricorn proctoscope. Operation duration amounted 24-45 minutes (32+/-5.21). Postoperative pain syndrome amounted on average 33.2+/-0.52 mm (range 20-50 mm) on the first day and 16.5+/-0.10 (0-40 mm) during 5 days which didn't require usage of narcotic analgesics. Patients returned to labor activity after 2-4 days (2.79+/-0.81). They were investigated after 6 months after operation. Bleeding stopped in 96.5% of patients, prolapsed piles were not observed in 91.8% of patients. Repeated bleedings were not registered. Complications (perianal hematoma-like external node thrombosis) were revealed in 7 (8.2%) patients. Trans-anal disarterization of internal hemorrhoids under Doppler control with mucopexy and lifting is a safe and effective alternative to hemorrhoidectomy. This method is ideal for "one-day" hospital.

Miniaturization and automation of an internally cooled coated fiber device.

PubMed

Chen, Yong; Pawliszyn, Janusz

2006-07-15

The internally cooled coated fiber device was miniaturized to allow its direct introduction into a gas chromatography injector, while maintaining a reasonable lifetime of the septum. The device was robust, and its fiber, which was accommodated in an 18-gauge needle, was reproducibly used for more than 100 injections without any coating failure. The fiber temperature was controlled within 5 degrees C of the preset value by use of a temperature controller, a solenoid valve, and stainless steel tubings with different inner diameter. The device was mounted and used on the CTC CombiPAL autosampler with minor modifications, such as enlarging the hole of the needle guide of the autosampler and coupling the temperature control system of the device to the autosampler through a logic circuit. The device was validated with the back equilibration of hydrocarbons preloaded in the fiber in air. The automation of the internally cooled coated fiber device provided the feasibility of high throughput for the analysis of analytes in complex matrixes that required simultaneous heating of the sample matrixes and cooling of the fiber coating.

From SARS to Avian Influenza: The Role of International Factors in China's Approach to Infectious Disease Control.

PubMed

Goldizen, Fiona C

2016-01-01

Over the past decades global environmental change, globalization, urbanization, and the rise in movement of people have increased the risk for pandemic disease outbreaks. As environmental exposures do not respect state borders, a globalist concept of global health response has developed, which requires transparency and cooperation for coordinated responses to disease outbreaks. Countries that avoid cooperation on health issues for social or political reasons can endanger the global community. The aim of this study was to examine the rapid change in China's infectious disease policy between 2000 and 2013, from actively rejecting the assistance of international health experts during the HIV/AIDS and severe acute respiratory syndrome crises to following best-practice disease response policies and cooperating with international health actors during the 2013 avian influenza outbreak. Using international relations theory, I examined whether international political factors had a major influence on this change. Using the case studies of international reputation, socialization with international organizations, and the securitization of infectious disease, this study examined the influence of international and domestic pressures on Chinese infectious disease policy. Although international relations theory, especially theories popular in global health diplomacy literature, provide valuable insight into the role of international factors and foreign policy interests in China's changing approach to infectious disease control, it cannot provide viable explanations without considering the domestic interests of the Chinese government. Analysis of state responses to infectious disease using international relations theories must consider domestic political factors. Copyright © 2016 The Author. Published by Elsevier Inc. All rights reserved.

Regulatory experience in applying a radiological environmental protection framework for existing and planned nuclear facilities.

PubMed

Mihok, S; Thompson, P

2012-01-01

Frameworks and methods for the radiological protection of non-human biota have been evolving rapidly at the International Commission on Radiological Protection and through various European initiatives. The International Atomic Energy Agency has incorporated a requirement for environmental protection in the latest revision of its Basic Safety Standards. In Canada, the Canadian Nuclear Safety Commission has been legally obligated to prevent unreasonable risk to the environment since 2000. Licensees have therefore been meeting generic legal requirements to demonstrate adequate control of releases of radioactive substances for the protection of both people and biota for many years. In the USA, in addition to the generic requirements of the Environmental Protection Agency and the Nuclear Regulatory Commission, Department of Energy facilities have also had to comply with specific dose limits after a standard assessment methodology was finalised in 2002. Canadian regulators developed a similar framework for biota dose assessment through a regulatory assessment under the Canadian Environmental Protection Act in the late 1990s. Since then, this framework has been applied extensively to satisfy legal requirements under the Canadian Environmental Assessment Act and the Nuclear Safety and Control Act. After approximately a decade of experience in applying these methods, it is clear that simple methods are fit for purpose, and can be used for making regulatory decisions for existing and planned nuclear facilities. Copyright © 2012. Published by Elsevier Ltd.

International Space Station alpha remote manipulator system workstation controls test report

NASA Astrophysics Data System (ADS)

Ehrenstrom, William A.; Swaney, Colin; Forrester, Patrick

1994-05-01

Previous development testing for the space station remote manipulator system workstation controls determined the need for hardware controls for the emergency stop, brakes on/off, and some camera functions. This report documents the results of an evaluation to further determine control implementation requirements, requested by the Canadian Space Agency (CSA), to close outstanding review item discrepancies. This test was conducted at the Johnson Space Center's Space Station Mockup and Trainer Facility in Houston, Texas, with nine NASA astronauts and one CSA astronaut as operators. This test evaluated camera iris and focus, back-up drive, latching end effector release, and autosequence controls using several types of hardware and software implementations. Recommendations resulting from the testing included providing guarded hardware buttons to prevent accidental actuation, providing autosequence controls and back-up drive controls on a dedicated hardware control panel, and that 'latch on/latch off', or on-screen software, controls not be considered. Generally, the operators preferred hardware controls although other control implementations were acceptable. The results of this evaluation will be used along with further testing to define specific requirements for the workstation design.

International Space Station alpha remote manipulator system workstation controls test report

NASA Technical Reports Server (NTRS)

Ehrenstrom, William A.; Swaney, Colin; Forrester, Patrick

1994-01-01

Previous development testing for the space station remote manipulator system workstation controls determined the need for hardware controls for the emergency stop, brakes on/off, and some camera functions. This report documents the results of an evaluation to further determine control implementation requirements, requested by the Canadian Space Agency (CSA), to close outstanding review item discrepancies. This test was conducted at the Johnson Space Center's Space Station Mockup and Trainer Facility in Houston, Texas, with nine NASA astronauts and one CSA astronaut as operators. This test evaluated camera iris and focus, back-up drive, latching end effector release, and autosequence controls using several types of hardware and software implementations. Recommendations resulting from the testing included providing guarded hardware buttons to prevent accidental actuation, providing autosequence controls and back-up drive controls on a dedicated hardware control panel, and that 'latch on/latch off', or on-screen software, controls not be considered. Generally, the operators preferred hardware controls although other control implementations were acceptable. The results of this evaluation will be used along with further testing to define specific requirements for the workstation design.

Improved LED backlight with unique color and intensity control and NVIS capability

NASA Astrophysics Data System (ADS)

Herman, Robert; Zagar, Pete; Ulijasz, Ted; Hansen, Hans C.; Ellner, Fred

2006-05-01

Currently deployed conventional flat panel AMLCD displays employ fluorescent lamp backlights to achieve the required lighting levels for cockpits in high performance aircraft. Advances have been made in backlighting technology by replacing fluorescent lamps with high performance LEDs. However, these new LED-based backlights are lacking in control of color and luminance intensity especially when related to NVIS requirements in a cockpit. This paper describes a unique integration of LED, electronic, and optical components to meet the requirements of high performance aircraft over their extreme range of operating environments. The LED-based backlight utilizes state-of-art components to enable daylight, night, and NVIS requirements to be implemented in a simple cost-effective package. The performance results presented highlight the advantages of this new design when compared to currently available backlighting designs. Techniques as described in section 2 of this paper are covered under patent application to the US and International Patent Offices.

Preliminary design of the Space Station internal thermal control system

NASA Technical Reports Server (NTRS)

Herrin, Mark T.; Patterson, David W.; Turner, Larry D.

1987-01-01

The baseline preliminary design configuration of the Internal Thermal Control system (ITCS) of the U.S. Space Station pressurized elements (i.e., the Habitation and U.S. Laboratory modules, pressurized logistics carrier, and resources nodes) is defined. The ITCS is composed of both active and passive components. The subsystems which comprise the ITCS are identified and their functional descriptions are provided. The significant trades and analyses, which were performed during Phase B (i.e., the preliminary design phase) that resulted in the design described herein, are discussed. The ITCS interfaces with the station's central Heat Rejection and Transport System (HRTS), other systems, and externally attached pressurized payloads are described. Requirements on the ITCS with regard to redundancy and experiment support are also addressed.

De-boned beef - an example of a commodity for which specific standards could be developed to ensure an appropriate level of protection for international trade.

PubMed

Thomson, G R; Leyland, T J; Donaldson, A I

2009-03-01

De-boned beef from which lymph nodes and risk material associated with bovine spongiform encephalopathy have been removed, is a product which can be produced for safe international trade irrespective of whether the locality of production is recognized as free from so-called transboundary diseases or not. Further processing of such beef provides an additional safety factor. However, this approach requires specific control measures being in place, supported by appropriate auditing and certification procedures. This document presents the arguments supporting this concept and details how safety in respect of both animal diseases and human food safety can be achieved using an integrated hazard analysis and critical control points approach.

ESA Human rating Requirements:Status

NASA Astrophysics Data System (ADS)

Trujillo, M.; Sgobba, T.

2012-01-01

The European Space Agency (ESA) human rating safety requirements are based on heritage requirements of the International Space Station as well as the knowledge and experience derived from European participation on international partnerships. This expertise in conjunction with recommendations derived from past accidents (i.e.: Columbia) and lessons learned have led to the identification of m inimum core safety tech nical requirements for hum an rated space syst ems. These requirements apply to th e crewed space vehicle, integrated space system (i.e.: cre wed vehicle on its launcher) and its interfaces with control centres, la unch pad, etc. In 2009, a first draft was issued. Then, in the summer of 2010, ESA established a working group comprised of more than twenty experts (from disciplines including propulsion, pyrotechnics, structures, avionics, human factors and life support among others) across the Agency to review this draft. This paper provides an overview of ESA "Safety technical re quirements for human rated s pace systems" document, its scope a nd structure, as well as the planned steps for verification of these requirements in term s of achieving the identified safety objectives for crew safety in t erms of a quantitative risk evaluation.

Deriving proper measurement uncertainty from Internal Quality Control data: An impossible mission?

PubMed

Ceriotti, Ferruccio

2018-03-30

Measurement uncertainty (MU) is a "non-negative parameter characterizing the dispersion of the quantity values being attributed to a measurand, based on the information used". In the clinical laboratory the most convenient way to calculate MU is the "top down" approach based on the use of Internal Quality Control data. As indicated in the definition, MU depends on the information used for its calculation and so different estimates of MU can be obtained. The most problematic aspect is how to deal with bias. In fact bias is difficult to detect and quantify and it should be corrected including only the uncertainty derived from this correction. Several approaches to calculate MU starting from Internal Quality Control data are presented. The minimum requirement is to use only the intermediate precision data, provided to include 6 months of results obtained with a commutable quality control material at a concentration close to the clinical decision limit. This approach is the minimal requirement and it is convenient for all those measurands that are especially used for monitoring or where a reference measurement system does not exist and so a reference for calculating the bias is lacking. Other formulas including the uncertainty of the value of the calibrator, including the bias from a commutable certified reference material or from a material specifically prepared for trueness verification, including the bias derived from External Quality Assessment schemes or from historical mean of the laboratory are presented and commented. MU is an important parameter, but a single, agreed upon way to calculate it in a clinical laboratory is not yet available. Copyright © 2018 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Approaches to quality management and accreditation in a genetic testing laboratory

PubMed Central

Berwouts, Sarah; Morris, Michael A; Dequeker, Elisabeth

2010-01-01

Medical laboratories, and specifically genetic testing laboratories, provide vital medical services to different clients: clinicians requesting a test, patients from whom the sample was collected, public health and medical-legal instances, referral laboratories and authoritative bodies. All expect results that are accurate and obtained in an efficient and effective manner, within a suitable time frame and at acceptable cost. There are different ways of achieving the end results, but compliance with International Organization for Standardization (ISO) 15189, the international standard for the accreditation of medical laboratories, is becoming progressively accepted as the optimal approach to assuring quality in medical testing. We present recommendations and strategies designed to aid genetic testing laboratories with the implementation of a quality management system, including key aspects such as document control, external quality assessment, internal quality control, internal audit, management review, validation, as well as managing the human side of change. The focus is on pragmatic approaches to attain the levels of quality management and quality assurance required for accreditation according to ISO 15189, within the context of genetic testing. Attention is also given to implementing efficient and effective quality improvement. PMID:20720559

48 CFR 752.7032 - International travel approval and notification requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false International travel... of USAID Contract Clauses 752.7032 International travel approval and notification requirements. For use in any USAID contract requiring international travel. International Travel Approval and...

48 CFR 752.7032 - International travel approval and notification requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false International travel... of USAID Contract Clauses 752.7032 International travel approval and notification requirements. For use in any USAID contract requiring international travel. International Travel Approval and...

48 CFR 752.7032 - International travel approval and notification requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false International travel... of USAID Contract Clauses 752.7032 International travel approval and notification requirements. For use in any USAID contract requiring international travel. International Travel Approval and...

48 CFR 752.7032 - International travel approval and notification requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false International travel... of USAID Contract Clauses 752.7032 International travel approval and notification requirements. For use in any USAID contract requiring international travel. International Travel Approval and...

48 CFR 752.7032 - International travel approval and notification requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false International travel... of USAID Contract Clauses 752.7032 International travel approval and notification requirements. For use in any USAID contract requiring international travel. International Travel Approval and...

Comparison of A-SMGCS Requirements with Observed Performance of an Integrated Airport CNS System

NASA Technical Reports Server (NTRS)

Young, Steven D.

1997-01-01

The International Civil Aviation Organization (ICAO) has recently drafted a reference document describing the operational requirements for Advanced Surface Movement Guidance and Control Systems (A-SMGCS). During the summer of 1997, NASA, the FAA, industry, and academia partners demonstrated a holistic system approach that has the potential to meet many of the proposed A-SMGCS requirements. An assessment of the field tested system and data resulting from the field testing is presented to determine its compliance with A-SMGCS requirements. In those areas where compliance was not demonstrated, a recommendation is presented suggesting further research or a modification of the system architecture.

Hanford Internal Dosimetry Project manual. Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carbaugh, E.H.; Bihl, D.E.; MacLellan, J.A.

1994-07-01

This document describes the Hanford Internal Dosimetry Project, as it is administered by Pacific Northwest Laboratory (PNL) in support of the US Department of Energy and its Hanford contractors. Project services include administrating the bioassay monitoring program, evaluating and documenting assessment of potential intakes and internal dose, ensuring that analytical laboratories conform to requirements, selecting and applying appropriate models and procedures for evaluating radionuclide deposition and the resulting dose, and technically guiding and supporting Hanford contractors in matters regarding internal dosimetry. Specific chapters deal with the following subjects: practices of the project, including interpretation of applicable DOE Orders, regulations, andmore » guidance into criteria for assessment, documentation, and reporting of doses; assessment of internal dose, including summary explanations of when and how assessments are performed; recording and reporting practices for internal dose; selection of workers for bioassay monitoring and establishment of type and frequency of bioassay measurements; capability and scheduling of bioassay monitoring services; recommended dosimetry response to potential internal exposure incidents; quality control and quality assurance provisions of the program.« less

A review of the International Atomic Energy Agency (IAEA) international standards for tissue banks.

PubMed

Morales Pedraza, Jorge; Lobo Gajiwala, Astrid; Martinez Pardo, María Esther

2012-03-01

The IAEA International Standards for Tissue Banks published in 2003 were based on the Standards then currently in use in the USA and the European Union, among others, and reflect the best practices associated with the operation of a tissue bank. They cover legal, ethical and regulatory controls as well as requirements and procedures from donor selection and tissue retrieval to processing and distribution of finished tissue for clinical use. The application of these standards allows tissue banks to operate with the current good tissue practice, thereby providing grafts of high quality that satisfy the national and international demand for safe and biologically useful grafts. The objective of this article is to review the IAEA Standards and recommend new topics that could improve the current version.

Selecting and Improving Quasi-Experimental Designs in Effectiveness and Implementation Research.

PubMed

Handley, Margaret A; Lyles, Courtney R; McCulloch, Charles; Cattamanchi, Adithya

2018-04-01

Interventional researchers face many design challenges when assessing intervention implementation in real-world settings. Intervention implementation requires holding fast on internal validity needs while incorporating external validity considerations (such as uptake by diverse subpopulations, acceptability, cost, and sustainability). Quasi-experimental designs (QEDs) are increasingly employed to achieve a balance between internal and external validity. Although these designs are often referred to and summarized in terms of logistical benefits, there is still uncertainty about (a) selecting from among various QEDs and (b) developing strategies to strengthen the internal and external validity of QEDs. We focus here on commonly used QEDs (prepost designs with nonequivalent control groups, interrupted time series, and stepped-wedge designs) and discuss several variants that maximize internal and external validity at the design, execution and implementation, and analysis stages.

Cold Stowage: An ISS Project

NASA Technical Reports Server (NTRS)

Hartley, Garen

2018-01-01

NASA's vision for humans pursuing deep space flight involves the collection of science in low earth orbit aboard the International Space Station (ISS). As a service to the science community, Johnson Space Center (JSC) has developed hardware and processes to preserve collected science on the ISS and transfer it safely back to the Principal Investigators. This hardware includes an array of freezers, refrigerators, and incubators. The Cold Stowage team is part of the International Space Station (ISS) program. JSC manages the operation, support and integration tasks provided by Jacobs Technology and the University of Alabama Birmingham (UAB). Cold Stowage provides controlled environments to meet temperature requirements during ascent, on-orbit operations and return, in relation to International Space Station Payload Science.

37 CFR 1.433 - Physical requirements of international application.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Physical requirements of... Provisions The International Application § 1.433 Physical requirements of international application. (a) The... must be on A4 size paper (21.0×29.7 cm.). (c) Other physical requirements for international...

37 CFR 1.433 - Physical requirements of international application.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Physical requirements of... Provisions The International Application § 1.433 Physical requirements of international application. (a) The... must be on A4 size paper (21.0 × 29.7 cm.). (c) Other physical requirements for international...

37 CFR 1.433 - Physical requirements of international application.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Physical requirements of... Provisions The International Application § 1.433 Physical requirements of international application. (a) The... must be on A4 size paper (21.0×29.7 cm.). (c) Other physical requirements for international...

37 CFR 1.433 - Physical requirements of international application.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Physical requirements of... Provisions The International Application § 1.433 Physical requirements of international application. (a) The... must be on A4 size paper (21.0 × 29.7 cm.). (c) Other physical requirements for international...

37 CFR 1.433 - Physical requirements of international application.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Physical requirements of... Provisions The International Application § 1.433 Physical requirements of international application. (a) The... must be on A4 size paper (21.0×29.7 cm.). (c) Other physical requirements for international...

Protocol for the validation of microbiological control of cellular products according to German regulators recommendations--Boon and Bane for the manufacturer.

PubMed

Störmer, M; Radojska, S; Hos, N J; Gathof, B S

2015-04-01

In order to generate standardized conditions for the microbiological control of HPCs, the PEI recommended defined steps for validation that will lead to extensive validation as shown in this study, where a possible validation principle for the microbiological control of allogeneic SCPs is presented. Although it could be demonstrated that automated culture improves microbial safety of cellular products, the requirement for extensive validation studies needs to be considered. © 2014 International Society of Blood Transfusion.

Advanced Environmental Monitoring and Control Program: Technology Development Requirements

NASA Technical Reports Server (NTRS)

Jan, Darrell (Editor); Seshan, Panchalam (Editor); Ganapathi, Gani (Editor); Schmidt, Gregory (Editor); Doarn, Charles (Editor)

1996-01-01

Human missions in space, from the International Space Station on towards potential human exploration of the moon, Mars and beyond into the solar system, will require advanced systems to maintain an environment that supports human life. These systems will have to recycle air and water for many months or years at a time, and avoid harmful chemical or microbial contamination. NASA's Advanced Environmental Monitoring and Control program has the mission of providing future spacecraft with advanced, integrated networks of microminiaturized sensors to accurately determine and control the physical, chemical and biological environment of the crew living areas. This document sets out the current state of knowledge for requirements for monitoring the crew environment, based on (1) crew health, and (2) life support monitoring systems. Both areas are updated continuously through research and space mission experience. The technologies developed must meet the needs of future life support systems and of crew health monitoring. These technologies must be inexpensive and lightweight, and use few resources. Using these requirements to continue to push the state of the art in miniaturized sensor and control systems will produce revolutionary technologies to enable detailed knowledge of the crew environment.

Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture.

PubMed

Ayala, Guillermo; Díez, Fernando; Gassó, María T; Jones, Brian E; Martín-Portugués, Rafael; Ramiro-Aparicio, Juan

2016-04-30

The internal lubricant content (ILC) of inhalation grade HPMC capsules is a key factor to ensure good powder release when the patient inhales a medicine from a dry powder inhaler (DPI). Powder release from capsules has been shown to be influenced by the ILC. The characteristics used to measure this are the emitted dose, fine particle fraction and mass median aerodynamic diameter. In addition the ILC level is critical for capsule shell manufacture because it is an essential part of the process that cannot work without it. An experiment has been applied to the manufacture of inhalation capsules with the required ILC. A full factorial model was used to identify the controlling factors and from this a linear model has been proposed to improve control of the process. Copyright © 2016 Elsevier B.V. All rights reserved.

78 FR 22269 - International Conference on Harmonisation; Draft Guidance on M7 Assessment and Control of DNA...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

...The Food and Drug Administration (FDA) is announcing the availability of a draft guidance entitled ``M7 Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk.'' The draft guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The draft guidance emphasizes considerations of both safety and quality risk management in establishing levels of mutagenic impurities that are expected to pose negligible carcinogenic risk. It outlines recommendations for assessment and control of mutagenic impurities that reside or are reasonably expected to reside in a final drug substance or product, taking into consideration the intended conditions of human use. The draft guidance is intended to provide guidance for new drug substances and new drug products during their clinical development and subsequent applications for marketing.

Advanced approach to information security management system model for industrial control system.

PubMed

Park, Sanghyun; Lee, Kyungho

2014-01-01

Organizations make use of important information in day-to-day business. Protecting sensitive information is imperative and must be managed. Companies in many parts of the world protect sensitive information using the international standard known as the information security management system (ISMS). ISO 27000 series is the international standard ISMS used to protect confidentiality, integrity, and availability of sensitive information. While an ISMS based on ISO 27000 series has no particular flaws for general information systems, it is unfit to manage sensitive information for industrial control systems (ICSs) because the first priority of industrial control is safety of the system. Therefore, a new information security management system based on confidentiality, integrity, and availability as well as safety is required for ICSs. This new ISMS must be mutually exclusive of an ICS. This paper provides a new paradigm of ISMS for ICSs, which will be shown to be more suitable than the existing ISMS.

Advanced Approach to Information Security Management System Model for Industrial Control System

PubMed Central

2014-01-01

Organizations make use of important information in day-to-day business. Protecting sensitive information is imperative and must be managed. Companies in many parts of the world protect sensitive information using the international standard known as the information security management system (ISMS). ISO 27000 series is the international standard ISMS used to protect confidentiality, integrity, and availability of sensitive information. While an ISMS based on ISO 27000 series has no particular flaws for general information systems, it is unfit to manage sensitive information for industrial control systems (ICSs) because the first priority of industrial control is safety of the system. Therefore, a new information security management system based on confidentiality, integrity, and availability as well as safety is required for ICSs. This new ISMS must be mutually exclusive of an ICS. This paper provides a new paradigm of ISMS for ICSs, which will be shown to be more suitable than the existing ISMS. PMID:25136659

Feasibility of using piezoelectric actuators to control launch vehicle acoustics and structural vibrations

NASA Astrophysics Data System (ADS)

Niezrecki, Christopher; Cudney, Harley H.

2000-06-01

Future launch vehicle payload fairings will be manufactured form advanced lightweight composite materials. The loss of distributed mass causes a significant increase in the internal acoustic environment, causing a severe threat to the payload. Using piezoelectric actuators to control the fairing vibration and the internal acoustic environment has been proposed. To help determine the acoustic control authority of piezoelectric actuators mounted on a rocket fairing, the internal acoustic response created by the actuators needs to be determined. In this work, the internal acoustic response of a closed simply-supported (SS) cylinder actuated by piezoelectric (PZT) actuators is determined using a n impedance model for the actuator and boundary element analysis. The experimentally validated model is used to extrapolate results for a SS cylinder that emulates a Minotaur payload fairing. The internal cylinder acoustic levels are investigated for PZT actuation between 35 and 400 Hz. Significant reductions in the structural response due to increased damping do not equate to similar reductions in the acoustic SPLs for the cylinder. The sound levels at the acoustic resonant frequencies are essentially unaffected by the significant increase in structural damping while the acoustic level sat the structural resonant frequencies are mildly reduced. The interior acoustic response of the cylinder is dominated by the acoustic modes and therefore significant reductions in the overall interior acoustic levels will not be achieved if only the structural resonances are controlled. As the actuation frequency is reduced, the number of actuators required to generate acoustic levels commensurate to that found in the fairing increases to impractical values. Below approximately 100 Hz, the current demands reach levels that are extremely difficult to achieve with a practical system. The results of this work imply that PZT actuators do not have the authority to control the payload fairing internal acoustics below approximately 100 Hz.

Nonlinear Attitude Control of Planar Structures in Space Using Only Internal Controls

NASA Technical Reports Server (NTRS)

Reyhanoglu, Mahmut; Mcclamroch, N. Harris

1993-01-01

An attitude control strategy for maneuvers of an interconnection of planar bodies in space is developed. It is assumed that there are no exogeneous torques and that torques generated by joint motors are used as means of control so that the total angular momentum of the multibody system is a constant, assumed to be zero. The control strategy utilizes the nonintegrability of the expression for the angular momentum. Large angle maneuvers can be designed to achieve an arbitrary reorientation of the multibody system with respect to an inertial frame. The theoretical background for carrying out the required maneuvers is summarized.

Internal quality control: best practice.

PubMed

Kinns, Helen; Pitkin, Sarah; Housley, David; Freedman, Danielle B

2013-12-01

There is a wide variation in laboratory practice with regard to implementation and review of internal quality control (IQC). A poor approach can lead to a spectrum of scenarios from validation of incorrect patient results to over investigation of falsely rejected analytical runs. This article will provide a practical approach for the routine clinical biochemistry laboratory to introduce an efficient quality control system that will optimise error detection and reduce the rate of false rejection. Each stage of the IQC system is considered, from selection of IQC material to selection of IQC rules, and finally the appropriate action to follow when a rejection signal has been obtained. The main objective of IQC is to ensure day-to-day consistency of an analytical process and thus help to determine whether patient results are reliable enough to be released. The required quality and assay performance varies between analytes as does the definition of a clinically significant error. Unfortunately many laboratories currently decide what is clinically significant at the troubleshooting stage. Assay-specific IQC systems will reduce the number of inappropriate sample-run rejections compared with the blanket use of one IQC rule. In practice, only three or four different IQC rules are required for the whole of the routine biochemistry repertoire as assays are assigned into groups based on performance. The tools to categorise performance and assign IQC rules based on that performance are presented. Although significant investment of time and education is required prior to implementation, laboratories have shown that such systems achieve considerable reductions in cost and labour.

Advanced computer-aided design for bone tissue-engineering scaffolds.

PubMed

Ramin, E; Harris, R A

2009-04-01

The design of scaffolds with an intricate and controlled internal structure represents a challenge for tissue engineering. Several scaffold-manufacturing techniques allow the creation of complex architectures but with little or no control over the main features of the channel network such as the size, shape, and interconnectivity of each individual channel, resulting in intricate but random structures. The combined use of computer-aided design (CAD) systems and layer-manufacturing techniques allows a high degree of control over these parameters with few limitations in terms of achievable complexity. However, the design of complex and intricate networks of channels required in CAD is extremely time-consuming since manually modelling hundreds of different geometrical elements, all with different parameters, may require several days to design individual scaffold structures. An automated design methodology is proposed by this research to overcome these limitations. This approach involves the investigation of novel software algorithms, which are able to interact with a conventional CAD program and permit the automated design of several geometrical elements, each with a different size and shape. In this work, the variability of the parameters required to define each geometry has been set as random, but any other distribution could have been adopted. This methodology has been used to design five cubic scaffolds with interconnected pore channels that range from 200 to 800 microm in diameter, each with an increased complexity of the internal geometrical arrangement. A clinical case study, consisting of an integration of one of these geometries with a craniofacial implant, is then presented.

The politics of space - Who owns what? Earth law for space

NASA Technical Reports Server (NTRS)

Hosenball, S. N.

1983-01-01

Topics of concern in developing space law, i.e., international disagreements, the present status of space law, and requirements for future space activities, are discussed. Factors inhibiting agreements include governments that wish to control specific regions of GEO, the refusal of several countries to permit international DBS television broadcasts over their boundaries, the possibility that weapons may be placed in space, and the lack of international laws governing humans and industries in space. It is noted that any state entering an international agreement has relinquished some of its sovereignty. The Outer Space Treaty has removed celestial bodies from claims of national appropriation. States retain sovereignty over their citizens who travel in space, a problematical concept once internationally-manned settlements in space or on the moon are established. It is recommended that space law develop mainly in reaction to the implementation of new space capabilities in order to avoid hindering space activities.

International Dengue Vaccine Communication and Advocacy: Challenges and Way Forward.

PubMed

Carvalho, Ana; Van Roy, Rebecca; Andrus, Jon

2016-01-01

Dengue vaccine introduction will likely occur soon. However, little has been published on international dengue vaccine communication and advocacy. More effort at the international level is required to review, unify and strategically disseminate dengue vaccine knowledge to endemic countries' decision makers and potential donors. Waiting to plan for the introduction of new vaccines until licensure may delay access in developing countries. Concerted efforts to communicate and advocate for vaccines prior to licensure are likely challenged by unknowns of the use of dengue vaccines and the disease, including uncertainties of vaccine impact, vaccine access and dengue's complex pathogenesis and epidemiology. Nevertheless, the international community has the opportunity to apply previous best practices for vaccine communication and advocacy. The following key strategies will strengthen international dengue vaccine communication and advocacy: consolidating existing coalitions under one strategic umbrella, urgently convening stakeholders to formulate the roadmap for integrated dengue prevention and control, and improving the dissemination of dengue scientific knowledge.

Science observations with the IUE using the one-gyro mode

NASA Technical Reports Server (NTRS)

Imhoff, C.; Pitts, R.; Arquilla, R.; Shrader, Chris R.; Perez, M. R.; Webb, J.

1990-01-01

The International Ultraviolet Explorer (IUE) attitude control system originally included an inertial reference package containing six gyroscopes for three axis stabilization. The science instrument includes a prime and redundant Field Error Sensor (FES) camera for target acquisition and offset guiding. Since launch, four of the six gyroscopes have failed. The current attitude control system utilizes the remaining two gyros and a Fine Sun Sensor (FSS) for three axis stabilization. When the next gyro fails, a new attitude control system will be uplinked which will rely on the remaining gyro and the FSS for general three axis stabilization. In addition to the FSS, the FES cameras will be required to assist in maintaining fine attitude control during target acquisition. This has required thoroughly determining the characteristics of the FES cameras and the spectrograph aperture plate as well as devising new target acquisition procedures. The results of this work are presented.

Science observations with the IUE using the one-gyro mode

NASA Technical Reports Server (NTRS)

Imhoff, C.; Pitts, R.; Arquilla, R.; Shrader, C.; Perez, M.; Webb, J.

1990-01-01

The International Ultraviolet Explorer (IUE) attitude control system originally included an inertial reference package containing six gyroscopes for three axis stabilization. The science instrument includes a prime and redundant Field Error Sensor (FES) camera for target acquisition and offset guiding. Since launch, four of the six gyroscopes have failed. The current attitude control system utilizes the remaining two gyros and a Fine Sun Sensor (FSS) for three axis stabilization. When the next gyro fails, a new attitude control system will be uplinked, which will relay on the remaining gyro and the FSS for general three axis stabilization. In addition to the FSS, the FES cameras will be required to assist in maintaining fine attitude control during target acquisition. This has required thoroughly determining the characteristics of the FES cameras and the spectrograph aperture plate as well as devising new target acquisition procedures. The results of this work are presented.

Advance and Retreat: Tobacco Control Policy in the U.S. Military

PubMed Central

Arvey, Sarah R.; Malone, Ruth E.

2009-01-01

This archival study explored why military tobacco control initiatives have thus far largely failed to meet their goals. We analyzed more than 5,000 previously undisclosed internal tobacco industry documents made public via an online database and additional documents obtained from the U.S. military. In four case studies, we illustrate how pressures exerted by multiple political actors resulted in weakening or rescinding military tobacco control policy initiatives. Our findings suggest that lowering military smoking rates will require health policymakers to better anticipate and counter political opponents. The findings also suggest that effective tobacco control policies may require strong, explicit implementation instructions and high-level Department of Defense support. Finally, policy designers should also consider ways to reduce or eliminate existing perverse incentives to increase tobacco consumption, such as allowing exchange store tobacco sales to fund Morale, Recreation, and Welfare Programs. PMID:19160617

Tackling tuberculosis: Insights from an international TB Summit in London

PubMed Central

Maitra, Arundhati; Danquah, Cynthia A; Scotti, Francesca; Howard, Tracey K; Kamil, Tengku K; Bhakta, Sanjib

2015-01-01

Tuberculosis (TB) poses a grave predicament to the world as it is not merely a scientific challenge but a socio-economic burden as well. A prime cause of mortality in human due to an infectious disease; the malady and its cause, Mycobacterium tuberculosis have remained an enigma with many questions that remain unanswered. The ability of the pathogen to survive and switch between varied physiological states necessitates a protracted therapeutic regimen that exerts an excessive strain on low-resource countries. To complicate things further, there has been a significant rise of antimicrobial resistance. Existing control measures, including treatment regimens have remained fairly uniform globally for at least half a century and require reinvention. Overcoming the societal and scientific challenges requires an increase in dialog to identify key regions that need attention and effective partners with whom successful collaborations can be fostered. In this report, we explore the discussions held at the International TB Summit 2015 hosted by EuroSciCon, which served as an excellent platform for researchers to share their recent findings. Ground-breaking results require outreach to affect policy design, governance and control of the disease. Hence, we feel it is important that meetings such as these reach a wider, global audience. PMID:26151309

Developments in Assisting Countries in Implementing the IAEA Additional Protocol

DOE Office of Scientific and Technical Information (OSTI.GOV)

Killinger, Mark H.; Hansen, Linda H.; Cain, Ronald A.

In 2008, the U.S. Department of Energy (DOE) began assisting selected non-nuclear weapon states in planning and preparing for implementation of the International Atomic Energy Agency’s Additional Protocol (AP). Since then, the AP international implementation program has contributed to the substantial progress made by Vietnam, Thailand, Iraq, and Malaysia in preparing for entry-into-force of the AP. An overall engagement plan has been developed with components designed to train government AP implementing agencies, inform policy makers, conduct outreach to industry and universities, make AP reporting software available and useful, and plan a detailed approach for implementing the declaration and complementary accessmore » provisions of the AP. DOE recently began collaborating with Indonesia, which has already entered the AP into force, requiring a second method of engagement somewhat different from that taken with countries that have not entered the AP into force. The AP international implementation program, administered by the International Nuclear Safeguards and Engagement Program, is working more closely with DOE’s International Nonproliferation Export Control Program to ensure countries are aware of and prepared to implement the export/import provisions of the AP. As the AP implementation program matures and helps move countries closer to entry-into-force or improved AP implementation, it is identifying characteristics of a country’s “end-state” that indicate that DOE assistance is no longer required. The U.S. AP Implementation Act and Senate Resolution of Ratification require the Administration to report annually to Congress on measures taken to achieve the adoption of the AP in non-nuclear weapon states. DOE’s AP international implementation program is a significant part of these measures. This paper describes recent developments to increase the scope and effectiveness of the program.« less

75 FR 37734 - Pasteuria usgae; Exemption from the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

.... Pasteuria, a genus of bacteria, includes a number of species that have shown potential in controlling plant-parasitic nematodes. These bacteria are obligate endoparasites, organisms that grow internally in a limited..., based on the toxicology test on rats presented in Unit III., along with the inability of the bacterium...

Report: Internal Control Weaknesses under EPA Grant Nos. I004802070 and BG96483308, Awarded to the Eastern Band of Cherokee Indians, Cherokee, North Carolina

EPA Pesticide Factsheets

Report #10-4-0001, October 5, 2009. EBCI does not have a conflict of interest and its SF 272s are correct and prepared in compliance with federal requirements, EPA policies, and grant terms and conditions.

Information Security in the Age of Cloud Computing

ERIC Educational Resources Information Center

Sims, J. Eric

2012-01-01

Information security has been a particularly hot topic since the enhanced internal control requirements of Sarbanes-Oxley (SOX) were introduced in 2002. At about this same time, cloud computing started its explosive growth. Outsourcing of mission-critical functions has always been a gamble for managers, but the advantages of cloud computing are…

78 FR 37277 - Proposed Collection: Comment Request for Form 1099-S

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

...: 1099-S. Abstract: Internal Revenue Code section 6045(e) and the regulations there under require persons... displays a valid OMB control number. Books or records relating to a collection of information must be... information technology; and (e) estimates of capital or start-up costs and costs of operation, maintenance...

25 CFR 291.4 - What must a proposal requesting Class III gaming procedures contain?

Code of Federal Regulations, 2011 CFR

2011-04-01

... activities of the Indian tribe's gaming operations; (4) Internal control standards designed to ensure fiscal..., maintenance, and accessibility; (6) Conduct of games, including patron requirements, posting of game rules, and hours of operation; (7) Procedures to protect the integrity of the rules for playing games; (8...

25 CFR 291.4 - What must a proposal requesting Class III gaming procedures contain?

Code of Federal Regulations, 2010 CFR

2010-04-01

... activities of the Indian tribe's gaming operations; (4) Internal control standards designed to ensure fiscal..., maintenance, and accessibility; (6) Conduct of games, including patron requirements, posting of game rules, and hours of operation; (7) Procedures to protect the integrity of the rules for playing games; (8...

25 CFR 291.4 - What must a proposal requesting Class III gaming procedures contain?

Code of Federal Regulations, 2013 CFR

2013-04-01

... activities of the Indian tribe's gaming operations; (4) Internal control standards designed to ensure fiscal..., maintenance, and accessibility; (6) Conduct of games, including patron requirements, posting of game rules, and hours of operation; (7) Procedures to protect the integrity of the rules for playing games; (8...

25 CFR 291.4 - What must a proposal requesting Class III gaming procedures contain?

Code of Federal Regulations, 2014 CFR

2014-04-01

... activities of the Indian tribe's gaming operations; (4) Internal control standards designed to ensure fiscal..., maintenance, and accessibility; (6) Conduct of games, including patron requirements, posting of game rules, and hours of operation; (7) Procedures to protect the integrity of the rules for playing games; (8...

25 CFR 291.4 - What must a proposal requesting Class III gaming procedures contain?

Code of Federal Regulations, 2012 CFR

2012-04-01

... activities of the Indian tribe's gaming operations; (4) Internal control standards designed to ensure fiscal..., maintenance, and accessibility; (6) Conduct of games, including patron requirements, posting of game rules, and hours of operation; (7) Procedures to protect the integrity of the rules for playing games; (8...

76 FR 74117 - Proposed Collection; Comment Request for Form 4810

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-30

..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form... collection of information displays a valid OMB control number. Books or records relating to a collection of... internal revenue law. Generally, tax returns and tax return information are confidential, as required by 26...

17 CFR 1.14 - Risk assessment recordkeeping requirements for futures commission merchants.

Code of Federal Regulations, 2010 CFR

2010-04-01

... alternative funding; (C) Establishing and maintaining internal controls with respect to market risk, credit... market, credit or other risk present in the activities of the affiliated person; and (v) The extent to... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Risk assessment recordkeeping...

77 FR 23305 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... Organizations Report to the Order Audit Trail System Information Barriers Put Into Place by the Member... Rule 5320 to require that member organizations report to the Order Audit Trail System (``OATS... implements and uses an effective system of internal controls--such as appropriate information barriers--that...

Internal Controls and Compliance with Laws and Regulations for the FY 1997 Financial Statements of Other Defense Organizations

DTIC Science & Technology

1998-07-13

requires DoD and other Government agencies to prepare consolidated financial statements for FY 1996 and each succeeding year. The DoD Consolidated ... Financial Statements for FY 1997 include financial statements for a reporting entity entitled Other Defense Organizations. This entity represents a

Introduction to Digital Logic Systems for Energy Monitoring and Control Systems.

DTIC Science & Technology

1985-05-01

computer were first set down by Charles Babbage in 1830. An additional criteria was proposed by Von Neumann in 1947. These criteria state: (1) An input means...criteria requirements as set down by Babbage and Von Neumann. The computer equipment ("hardware") and internal operating system ("software

47 CFR 63.25 - Special provisions relating to temporary or emergency service by international carriers.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., and beyond the control of, the carrier. (b) Applicants seeking immediate authorization to provide... why such immediate authority is required; the nature of the emergency; the type of facilities proposed... were in continuous effect for a period of more than one week, the following information: (1) The type...

40 CFR 63.653 - Monitoring, recordkeeping, and implementation plan for emissions averaging.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) For each emission point included in an emissions average, the owner or operator shall perform testing, monitoring, recordkeeping, and reporting equivalent to that required for Group 1 emission points complying... internal floating roof, external roof, or a closed vent system with a control device, as appropriate to the...

75 FR 32516 - Virginia Electric and Power Company; North Anna Power Station, Unit Nos. 1 and 2; Surry Power...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... Protection Against Radiation'' Subpart H, ``Respiratory Protection and Controls to Restrict Internal Exposure in Restricted Areas,'' establishes the requirements for implementing a respiratory protection program....1703(b) allow a licensee to seek authorization to use respiratory equipment that has not been tested...

40 CFR Appendix A to Part 31 - Audit Requirements for State and Local Government Recipients

Code of Federal Regulations, 2014 CFR

2014-07-01

... operations. A series of audits of individual departments, agencies, and establishments for the same fiscal... assurance the auditor must make a study and evaluation of internal control systems used in administering Federal assistance programs. The study and evaluation must be made whether or not the auditor intends to...

40 CFR Appendix A to Part 31 - Audit Requirements for State and Local Government Recipients

Code of Federal Regulations, 2011 CFR

2011-07-01

... operations. A series of audits of individual departments, agencies, and establishments for the same fiscal... assurance the auditor must make a study and evaluation of internal control systems used in administering Federal assistance programs. The study and evaluation must be made whether or not the auditor intends to...

40 CFR Appendix A to Part 31 - Audit Requirements for State and Local Government Recipients

Code of Federal Regulations, 2010 CFR

2010-07-01

... operations. A series of audits of individual departments, agencies, and establishments for the same fiscal... assurance the auditor must make a study and evaluation of internal control systems used in administering Federal assistance programs. The study and evaluation must be made whether or not the auditor intends to...

40 CFR Appendix A to Part 31 - Audit Requirements for State and Local Government Recipients

Code of Federal Regulations, 2012 CFR

2012-07-01

... operations. A series of audits of individual departments, agencies, and establishments for the same fiscal... assurance the auditor must make a study and evaluation of internal control systems used in administering Federal assistance programs. The study and evaluation must be made whether or not the auditor intends to...

40 CFR Appendix A to Part 31 - Audit Requirements for State and Local Government Recipients

Code of Federal Regulations, 2013 CFR

2013-07-01

... operations. A series of audits of individual departments, agencies, and establishments for the same fiscal... assurance the auditor must make a study and evaluation of internal control systems used in administering Federal assistance programs. The study and evaluation must be made whether or not the auditor intends to...

Database Tool for Master Console Operators

NASA Technical Reports Server (NTRS)

Ferrell, Sean

2018-01-01

The Spaceport Command and Control System (SCCS) is the National Aeronautics and Space Administration's (NASA) launch control system for the Orion capsule and Space Launch System, the next generation manned rocket currently in development. This large system requires highly trained and knowledgeable personnel. Master Console Operators (MCO) are currently working on familiarizing themselves with any possible scenario that they may encounter. An intern was recruited to help assist them with creating a tool to use for the process.

National Aeronautics and Space Administration: Leadership and Systems Needed to Effect Financial Management Improvements

DTIC Science & Technology

2002-03-20

financial reporting requirements-an unqualified opinion on its financial statements, no material internal control weaknesses, and financial management systems that are in substantial compliance the requirements of the Federal Financial Management Improvement Act (FFMIA). This implied that NASA not only could generate reliable information once a year for external financial reporting purposes but also could provide accurate, reliable information for day-today decision-making. In contrast with the unqualified or clean audit opinions of its previous

Adverse Effects in Dual-Star Interferometry

NASA Technical Reports Server (NTRS)

Colavita, M. Mark

2008-01-01

Narrow-angle dual-star interferometric astrometry can provide very high accuracy in the presence of the Earth's turbulent atmosphere. However, to exploit the high atmospherically-limited accuracy requires control of systematic errors in measurement of the interferometer baseline, internal OPDs, and fringe phase. In addition, as high photometric SNR is required, care must be taken to maximize throughput and coherence to obtain high accuracy on faint stars. This article reviews: the keys aspects of the dual-star approach and implementation; the main contributors to the

Design and Testing of Suit Regulator Test Rigs

NASA Technical Reports Server (NTRS)

Campbell, Colin

2010-01-01

The next generation space suit requires additional capabilities for controlling and adjusting internal pressure compared to that of historical designs. Next generation suit pressures will range from slight pressure, for astronaut prebreathe comfort, to hyperbaric pressure levels for emergency medical treatment of decompression sickness. In order to test these regulators through-out their development life cycle, novel automated test rigs are being developed. This paper addresses the design philosophy, performance requirements, physical implementation, and test results with various units under test.

Stereotactic radiation therapy for the treatment of functional pituitary adenomas associated with feline acromegaly.

PubMed

Wormhoudt, Tiffany L; Boss, Mary-Keara; Lunn, Katharine; Griffin, Lynn; Leary, Del; Dowers, Kristy; Rao, Sangeeta; LaRue, Susan M

2018-05-21

Conventional fractionated radiotherapy has been shown to be partially effective for management of pituitary tumors in cats that cause acromegaly and diabetes mellitus (DM), but, the efficacy and safety of stereotactic radiation therapy (SRT) as a treatment for acromegalic cats has not been described. Stereotactic radiation therapy is an effective and safe treatment for controlling acromegaly associated with pituitary adenomas in cats. Additionally, SRT-treated acromegalic cats with DM will experience a decrease in insulin requirements after radiation therapy. Fifty-three client-owned cats referred to Colorado State University for SRT to treat pituitary tumors causing poorly controlled DM secondary to acromegaly. Retrospective study of cats treated for acromegaly with SRT between 2008 and 2016 at Colorado State University. Diagnosis of acromegaly was based on history, physical examination, laboratory results, and cross-sectional imaging of the pituitary. Signalment, radiation protocol, insulin requirements over time, adverse effects, and survival were recorded. Median survival time was 1072 days. Of the 41 cats for which insulin dosage information was available, 95% (39/41) experienced a decrease in required insulin dose, with 32% (13/41) achieving diabetic remission. Remission was permanent in 62% (8/13) and temporary in 38% (5/13) cats. Median duration to lowest insulin dose was 9.5 months. Of the treated cats, 14% developed hypothyroidism and required supplementation after SRT. Stereotactic radiation therapy is safe and effective for treating cats with acromegaly. Cats treated with SRT have improved survival time and control of their DM when compared to previously reported patients treated with non-SRT. Copyright © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Moving beyond too little, too late: managing emerging infectious diseases in wild populations requires international policy and partnerships

USGS Publications Warehouse

Voyles, Jamie; Kilpatrick, A. Marm; Collins, James P.; Fisher, Matthew C.; Frick, Winifred F.; McCallum, Hamish I.; Willis, Craig K.R.; Blehert, David S.; Murray, Kris A.; Puschendorf, Robert; Rosenblum, Erica Bree; Bolker, Benjamin M.; Cheng, Tina L.; Langwig, Kate E.; Linder, Daniel L.; Toothman, Mary; Wilber, Mark Q.; Briggs, Cheryl J.

2015-01-01

Emerging infectious diseases (EIDs) are on the rise due to multiple factors, including human facilitated movement of pathogens, broad-scale landscape changes, and perturbations to ecological systems (Jones et al. 2008; Fisher et al. 2012). Epidemics in wildlife are problematic because they can lead to pathogen spillover to new host organisms, erode biodiversity and threaten ecosystems that sustain human societies (Fisher et al. 2012; Kilpatrick 2011). There have been recent calls for large-scale research approaches to combat threats EIDs pose to wildlife (Sleeman 2013). While it is true that developing new analytical models, diagnostic assays and molecular tools will significantly avance outr abilities to respond to disease threats, we also propose that addressing difficult problems in EIDs will require considerable shofts in international health policy and infrastructure. While there are currently international organizations responsbile for rapidly initiating and coordinating preventative measures to control infectious diseases in human, livestock, and arable systems, there are few comparable instiutions that have the authority to implement transnational responses to EIDs in wildlife. This absence of well-developed infastructure hampers the rapid responses necessary to mitigate international spread of EIDs.

Summarizing the evidence on the international trade in illegal wildlife.

PubMed

Rosen, Gail Emilia; Smith, Katherine F

2010-08-01

The global trade in illegal wildlife is a multi-billion dollar industry that threatens biodiversity and acts as a potential avenue for invasive species and disease spread. Despite the broad-sweeping implications of illegal wildlife sales, scientists have yet to describe the scope and scale of the trade. Here, we provide the most thorough and current description of the illegal wildlife trade using 12 years of seizure records compiled by TRAFFIC, the wildlife trade monitoring network. These records comprise 967 seizures including massive quantities of ivory, tiger skins, live reptiles, and other endangered wildlife and wildlife products. Most seizures originate in Southeast Asia, a recently identified hotspot for future emerging infectious diseases. To date, regulation and enforcement have been insufficient to effectively control the global trade in illegal wildlife at national and international scales. Effective control will require a multi-pronged approach including community-scale education and empowering local people to value wildlife, coordinated international regulation, and a greater allocation of national resources to on-the-ground enforcement.

Stability Control of Grasping Objects with Different Locations of Center of Mass and Rotational Inertia

PubMed Central

Slota, Gregory P.; Suh, Moon Suk; Latash, Mark L.; Zatsiorsky, Vladimir M.

2012-01-01

The objective of this study was to observe how the digits of the hand adjust to varying location of the center of mass (CoM) above/below the grasp and rotational inertia (RI) of a hand held object. Such manipulations do not immediately affect the equilibrium equations while stability control is affected. Participants were instructed to hold a handle, instrumented with five force/torque transducers and a 3-D rotational tilt sensor, while either the location of the CoM or the RI values were adjusted. On the whole, people use two mechanisms to adjust to the changed stability requirements; they increase the grip force and redistribute the total moment between the normal and tangential forces offsetting internal torques. The increase in grip force, an internal force, and offsetting internal torques allows for increases in joint and hand rotational apparent stiffness while not creating external forces/torques which would unbalance the equations of equilibrium. PMID:22456054

Foodborne disease control: a transnational challenge.

PubMed

Käferstein, F K; Motarjemi, Y; Bettcher, D W

1997-01-01

In the globalized political economy of the late 20th century, increasing social, political, and economic interdependence is occurring as a result of the rapid movement of people, images, values, and financial transactions across national borders. Another consequence of the increase in transnational trade, travel, and migration is the greater risk of cross-border transmission of infectious diseases. As the world becomes more interconnected, diseases spread more rapidly and effectively. With more than one million people crossing international borders every day, and with the globalization of food production, manufacturing, and marketing, the risk of infectious disease transmission is greater. Economic globalization has also increased the need for governmental budget austerity, and consequent national preparedness has been eroded. The emergence of new infectious diseases, as well as the reemergence of old ones, thus represents a crucial transnational policy issue. These problems cannot be resolved by national governments alone; they require international cooperation. This article analyzes the role of foodborne disease surveillance programs, nationally and internationally, in the control of foodborne diseases.

Foodborne disease control: a transnational challenge.

PubMed Central

Käferstein, F. K.; Motarjemi, Y.; Bettcher, D. W.

1997-01-01

In the globalized political economy of the late 20th century, increasing social, political, and economic interdependence is occurring as a result of the rapid movement of people, images, values, and financial transactions across national borders. Another consequence of the increase in transnational trade, travel, and migration is the greater risk of cross-border transmission of infectious diseases. As the world becomes more interconnected, diseases spread more rapidly and effectively. With more than one million people crossing international borders every day, and with the globalization of food production, manufacturing, and marketing, the risk of infectious disease transmission is greater. Economic globalization has also increased the need for governmental budget austerity, and consequent national preparedness has been eroded. The emergence of new infectious diseases, as well as the reemergence of old ones, thus represents a crucial transnational policy issue. These problems cannot be resolved by national governments alone; they require international cooperation. This article analyzes the role of foodborne disease surveillance programs, nationally and internationally, in the control of foodborne diseases. PMID:9368787

Control Laws for a Dual-Spin Stabilized Platform

NASA Technical Reports Server (NTRS)

Lim, K. B.; Moerder, D. D.

2008-01-01

This paper describes two attitude control laws suitable for atmospheric flight vehicles with a steady angular momentum bias in the vehicle yaw axis. This bias is assumed to be provided by an internal flywheel, and is introduced to enhance roll and pitch stiffness. The first control law is based on Lyapunov stability theory, and stability proofs are given. The second control law, which assumes that the angular momentum bias is large, is based on a classical PID control. It is shown that the large yaw-axis bias requires that the PI feedback component on the roll and pitch angle errors be cross-fed. Both control laws are applied to a vehicle simulation in the presence of disturbances for several values of yaw-axis angular momentum bias. It is seen that both control laws provide a significant improvement in attitude performance when the bias is sufficiently large, but the nonlinear control law is also able to provide improved performance for a small value of bias. This is important because the smaller bias corresponds to a smaller requirement for mass to be dedicated to the flywheel.

Leadership and Cultural Challenges in Operating the International Space Station

NASA Technical Reports Server (NTRS)

Clement, J. L.; Ritsher, J. B.; Saylor, S. A.; Kanas, N.

2006-01-01

Operating the International Space Station (ISS) involves an indefinite, continuous series of long-duration international missions, and this requires an unprecedented degree of cooperation across multiple sites, organizations, and nations. ISS flight controllers have had to find ways to maintain effective team performance in this challenging new context. The goal of this study was to systematically identify and evaluate the major leadership and cultural challenges faces by ISS flight controllers, and to highlight the approaches that they have found most effective to surmount these challenges. We conducted a qualitative survey using a semi-structured interview. Subjects included 14 senior NASA flight controllers who were chosen on the basis of having had substantial experience working with international partners. Data were content analyzed using an iterative process with multiple coders and consensus meetings to resolve discrepancies. To further explore the meaning of the interview findings, we also conducted some new analyses of data from a previous questionnaire study of Russian and American ISS mission control personnel. The interview data showed that respondents had substantial consensus on several leadership and cultural challenges and on key strategies for dealing with them, and they offered a wide range of specific tactics for implementing these strategies. Surprisingly few respondents offered strategies for addressing the challenge of working with team members whose native language is not American English. The questionnaire data showed that Americans think it is more important than Russians that mission control personnel speak the same dialect of one shared common language. Although specific to the ISS program, our results are consistent with recent management, cultural, and aerospace research. We aim to use our results to improve training for current and future ISS flight controllers.

The effect of a clinical medical librarian on in-patient care outcomes*

PubMed Central

Esparza, Julia M.; Shi, Runhua; McLarty, Jerry; Comegys, Marianne; Banks, Daniel E.

2013-01-01

Objective: The research sought to determine the effect of a clinical medical librarian (CML) on outcomes of in-patients on the internal medicine service. Methods: A prospective study was performed with two internal medicine in-patient teams. Team 1 included a CML who accompanied the team on daily rounds. The CML answered questions posed at the point of care immediately or in emails post-rounds. Patients on Team 2, which did not include a CML, as well as patients who did not require consultation by the CML on Team 1, served as the control population. Numerous clinical and library metrics were gathered on each question. Results: Patients on Team 1 who required an answer to a clinical question were more ill and had a longer length of stay, higher costs, and higher readmission rates compared to those in the control group. Using a matched pair analysis, we showed no difference in clinical outcomes between the intervention group and the control group. Conclusions: This study is the largest attempt to prospectively measure changes in patient outcomes when physicians were accompanied by a CML on rounds. This approach may serve as a model for further studies to define when and how CMLs are most effective. PMID:23930088

Improved vacuum sealing drainage for treatment of surgical site infection following posterior spinal internal fixation

PubMed Central

Zhang, Hengyan; Li, Qiyi

2018-01-01

Abstract Rationale: Surgical site infection (SSI) following spine surgeries involving internal fixation often require removing the instrument; however, this can cause spinal instability. Previous reports have demonstrated the usefulness of vacuum sealing drainage (VSD) therapy, but the cases require wound opening, aseptic condition to replace the VSD device, and a secondary operation to close the wound. Thus, to improve the VSD treatment and develop a maneuverable procedure, make sense in spine surgery. Patients concerns: A 59-year-old male patient with a T12 vertebral fracture was affected by SSIs after spinal osteotomy with internal fixation. Diagnoses: The patient complained of wound exudation and had a fever 3 weeks after posterior spinal surgery. Initial serum investigations showed elevated white blood cell count and bacterial cultures of wound exudate were positive for Enterococcus faecalis. Therefore, SSI is confirmed. Interventions: The infection was not controlled after 2 debridements, so the patient was treated with VSD treatment. The VSD foam dressings containing a drainage tube were placed into the wound from the exudation site of the wound until they contacted the internal fixation devices. After covering external fixation devices, continuous drainage was performed for 24 h. The VSD device was replaced every 4 to 5 days until the wound effusion stopped. All of the operations were performed at the bedside without complex manipulation or secondary closure under harsh aseptic condition. Outcomes: Wound exudation decreased remarkably and the infection was controlled 2 weeks after the application of VSD treatment. After 5 weeks, inflammatory indicators all decreased to normal levels and the exudate of the wound had stopped. The VSD treatment was then terminated and the drainage site of the wound was sutured. After 7 weeks, complete wound healing was achieved and no infection recurred during the 6-month follow-up. Lessons: VSD could be a reliable treatment for SSIs that require preservation of internal fixation. Complete opening of the wound during the VSD treatment and secondary wound closure surgery were avoided. PMID:29443786

Evaluation of the HACCP System in a University Canteen: Microbiological Monitoring and Internal Auditing as Verification Tools

PubMed Central

Osimani, Andrea; Aquilanti, Lucia; Tavoletti, Stefano; Clementi, Francesca

2013-01-01

Food safety is essential in mass catering. In Europe, Regulation (EC) No. 852/2004 requires food business operators to put in place, implement and maintain permanent procedures based on Hazard Analysis and Critical Control Point (HACCP) principles. Each HACCP plan is specifically implemented for the processing plant and processing methods and requires a systematic collection of data on the incidence, elimination, prevention, and reduction of risks. In this five-year-study, the effectiveness of the HACCP plan of a University canteen was verified through periodic internal auditing and microbiological monitoring of meals, small equipment, cooking tools, working surfaces, as well as hands and white coats of the canteen staff. The data obtained revealed no safety risks for the consumers, since Escherichia coli, Salmonella spp. and Listeria monocytogenes were never detected; however, a quite discontinuous microbiological quality of meals was revealed. The fluctuations in the microbial loads of mesophilic aerobes, coliforms, Staphylococcus aureus, Bacillus cereus, and sulphite-reducing clostridia were mainly ascribed to inadequate handling or processing procedures, thus suggesting the need for an enhancement of staff training activities and for a reorganization of tasks. Due to the wide variety of the fields covered by internal auditing, the full conformance to all the requirements was never achieved, though high scores, determined by assigning one point to each answer which matched with the requirements, were achieved in all the years. PMID:23594937

Evaluation of the HACCP system in a university canteen: microbiological monitoring and internal auditing as verification tools.

PubMed

Osimani, Andrea; Aquilanti, Lucia; Tavoletti, Stefano; Clementi, Francesca

2013-04-17

Food safety is essential in mass catering. In Europe, Regulation (EC) No. 852/2004 requires food business operators to put in place, implement and maintain permanent procedures based on Hazard Analysis and Critical Control Point (HACCP) principles. Each HACCP plan is specifically implemented for the processing plant and processing methods and requires a systematic collection of data on the incidence, elimination, prevention, and reduction of risks. In this five-year-study, the effectiveness of the HACCP plan of a University canteen was verified through periodic internal auditing and microbiological monitoring of meals, small equipment, cooking tools, working surfaces, as well as hands and white coats of the canteen staff. The data obtained revealed no safety risks for the consumers, since Escherichia coli, Salmonella spp. and Listeria monocytogenes were never detected; however, a quite discontinuous microbiological quality of meals was revealed. The fluctuations in the microbial loads of mesophilic aerobes, coliforms, Staphylococcus aureus, Bacillus cereus, and sulphite-reducing clostridia were mainly ascribed to inadequate handling or processing procedures, thus suggesting the need for an enhancement of staff training activities and for a reorganization of tasks. Due to the wide variety of the fields covered by internal auditing, the full conformance to all the requirements was never achieved, though high scores, determined by assigning one point to each answer which matched with the requirements, were achieved in all the years.

The importance of selecting the right internal control gene to study the effects of antenatal glucocorticoid administration in human placenta.

PubMed

Gütling, H; Bionaz, M; Sloboda, D M; Ehrlich, L; Braun, F; Gramzow, A K; Henrich, W; Plagemann, A; Braun, T

2016-08-01

RT-qPCR requires a suitable set of internal control genes (ICGs) for an accurate normalization. The usefulness of 7 previously published ICGs in the human placenta was analyzed according to the effects of betamethasone treatment, sex and fetal age. Raw RT-qPCR data of the ICGs were evaluated using published algorithms. The algorithms revealed that a reliable normalization was achieved using the geometrical mean of PPIA, RPL19, HMBS and SDHA. The use of a different subset ICGs out of the 7 investigated, although not statistically affected by the conditions, biased the results, as demonstrated through changes in expression of glucocorticoid receptor (NR3C1) mRNA as a target gene. Copyright © 2016 Elsevier Ltd. All rights reserved.

ASM LabCap's contributions to disease surveillance and the International Health Regulations (2005).

PubMed

Specter, Steven; Schuermann, Lily; Hakiruwizera, Celestin; Sow, Mah-Séré Keita

2010-12-03

The revised International Health Regulations [IHR(2005)], which requires the Member States of the World Health Organization (WHO) to develop core capacities to detect, assess, report, and respond to public health threats, is bringing new challenges for national and international surveillance systems. As more countries move toward implementation and/or strengthening of their infectious disease surveillance programs, the strengthening of clinical microbiology laboratories becomes increasingly important because they serve as the first line responders to detect new and emerging microbial threats, re-emerging infectious diseases, the spread of antibiotic resistance, and the possibility of bioterrorism. In fact, IHR(2005) Core Capacity #8, "Laboratory", requires that laboratory services be a part of every phase of alert and response.Public health laboratories in many resource-constrained countries require financial and technical assistance to build their capacity. In recognition of this, in 2006, the American Society for Microbiology (ASM) established an International Laboratory Capacity Building Program, LabCap, housed under the ASM International Board. ASM LabCap utilizes ASM's vast resources and its membership's expertise-40,000 microbiologists worldwide-to strengthen clinical and public health laboratory systems in low and low-middle income countries. ASM LabCap's program activities align with HR(2005) by building the capability of resource-constrained countries to develop quality-assured, laboratory-based information which is critical to disease surveillance and the rapid detection of disease outbreaks, whether they stem from natural, deliberate or accidental causes.ASM LabCap helps build laboratory capacity under a cooperative agreement with the U.S. Centers for Disease Control and Prevention (CDC) and under a sub-contract with the Program for Appropriate Technology in Health (PATH) funded by the United States Agency for International Development (USAID). Successful activities of ASM LabCap have occurred throughout Africa, Asia, Central America and the Caribbean. In addition, ASM LabCap coordinates efforts with international agencies such as the WHO in order to maximize resources and ensure a unified response, with the intended goal to help build integrated disease surveillance and response capabilities worldwide in compliance with HR(2005)'s requirements.

77 FR 36341 - Control of Air Pollution From Aircraft and Aircraft Engines; Emission Standards and Test Procedures

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-18

...EPA is adopting several new aircraft engine emission standards for oxides of nitrogen (NOX), compliance flexibilities, and other regulatory requirements for aircraft turbofan or turbojet engines with rated thrusts greater than 26.7 kilonewtons (kN). We also are adopting certain other requirements for gas turbine engines that are subject to exhaust emission standards as follows. First, we are clarifying when the emission characteristics of a new turbofan or turbojet engine model have become different enough from its existing parent engine design that it must conform to the most current emission standards. Second, we are establishing a new reporting requirement for manufacturers of gas turbine engines that are subject to any exhaust emission standard to provide us with timely and consistent emission- related information. Third, and finally, we are establishing amendments to aircraft engine test and emissions measurement procedures. EPA actively participated in the United Nations' International Civil Aviation Organization (ICAO) proceedings in which most of these requirements were first developed. These regulatory requirements have largely been adopted or are actively under consideration by its member states. By adopting such similar standards, therefore, the United States maintains consistency with these international efforts.

76 FR 45011 - Control of Air Pollution From Aircraft and Aircraft Engines; Proposed Emission Standards and Test...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-27

...This action proposes several new NOX emission standards, compliance flexibilities, and other regulatory requirements for aircraft turbofan or turbojet engines with rated thrusts greater than 26.7 kilonewtons (kN). We also are proposing certain other requirements for gas turbine engines that are subject to exhaust emission standards. First, we are proposing to clarify when the emission characteristics of a new turbofan or turbojet engine model have become different enough from its existing parent engine design that it must conform to the most current emission standards. Second, we are proposing a new reporting requirement for manufacturers of gas turbine engines that are subject to any exhaust emission standard to provide us with timely and consistent emission-related information. Third, and finally, we are proposing amendments to aircraft engine test and emissions measurement procedures. EPA actively participated in the United Nation's International Civil Aviation Organization (ICAO) proceedings in which most of these proposed requirements were first developed. These proposed regulatory requirements have largely been adopted or are actively under consideration by its member states. By adopting such similar standards, therefore, the United States will maintain consistency with these international efforts.

How to improve the promotion of Korean beef barbecue, bulgogi, for international customers. An application of quality function deployment.

PubMed

Park, So-Hyun; Ham, Sunny; Lee, Min-A

2012-10-01

Quality function deployment (QFD) is a product development technique that translates customer requirements into activities for the development of products and services. This study utilizes QFD to identify American customer's requirements for bulgogi, a popular Korean dish among international customers, and how to fulfill those requirements. A customer survey and an expert opinion survey were conducted for US customers. The top five customer requirements for bulgogi were identified as taste, freshness, flavor, tenderness, and juiciness; ease of purchase was included in the place of tenderness after calculating the weight requirements. Eighteen engineering characteristics were developed, and a 'localization of bulgogi menu' is strongly related to the other characteristics as well. The results from the calculation of relative importance of engineering characteristics identified that the 'control of marinating time', 'localization of bulgogi menu', 'improvement of cooking and serving process', 'development of recipe by parts of beef', and 'use of various seasonings' were the highest contributors to the overall improvement of bulgogi. The relative importance of engineering characteristics, correlation, and technical difficulties are ranked and integrated to develop the most effective strategy. The findings are discussed relative to industry implications. Copyright © 2012 Elsevier Ltd. All rights reserved.

Modern science for better quality control of medicinal products "Towards global harmonization of 3Rs in biologicals": The report of an EPAA workshop.

PubMed

Schutte, Katrin; Szczepanska, Anna; Halder, Marlies; Cussler, Klaus; Sauer, Ursula G; Stirling, Catrina; Uhlrich, Sylvie; Wilk-Zasadna, Iwona; John, David; Bopst, Martin; Garbe, Joerg; Glansbeek, Harrie L; Levis, Robin; Serreyn, Pieter-Jan; Smith, Dean; Stickings, Paul

2017-07-01

This article summarizes the outcome of an international workshop organized by the European Partnership for Alternative Approaches to Animal Testing (EPAA) on Modern science for better quality control of medicinal products: Towards global harmonization of 3Rs in biologicals. As regards the safety testing of biologicals, the workshop participants agreed to actively encourage the deletion of abnormal toxicity tests and target animal batch safety tests from all relevant legal requirements and guidance documents (country-specific guidelines, pharmacopoeia monographs, WHO recommendations). To facilitate the global regulatory acceptance of non-animal methods for the potency testing of, e.g., human diphtheria and tetanus vaccines and veterinary swine erysipelas vaccines, international convergence on the scientific principles of the use of appropriately validated in vitro assays for replacing in vivo methods was identified as an overarching goal. The establishment of scientific requirements for new assays was recognized as a further means to unify regulatory approaches in different jurisdictions. It was recommended to include key regulators and manufacturers early in the corresponding discussions. Manufacturers and responsible expert groups, e.g. at the European Directorate for the Quality of Medicines and Health Care of the Council of Europe or the European Medicines Agency, were invited to consider leadership for international collaboration. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Carbon Dioxide Removal Troubleshooting aboard the International Space Station (ISS) during Space Shuttle (STS) Docked Operations

NASA Technical Reports Server (NTRS)

Matty, Christopher M.; Cover, John M.

2009-01-01

The International Space Station (ISS) represents a largely closed-system habitable volume which requires active control of atmospheric constituents, including removal of exhaled Carbon Dioxide (CO2). The ISS provides a unique opportunity to observe system requirements for (CO2) removal. CO2 removal is managed by the Carbon Dioxide Removal Assembly (CDRA) aboard the US segment of ISS and by Lithium Hydroxide (LiOH) aboard the Space Shuttle (STS). While the ISS and STS are docked, various methods are used to balance the CO2 levels between the two vehicles, including mechanical air handling and management of general crew locations. Over the course of ISS operation, several unexpected anomalies have occurred which have required troubleshooting, including possible compromised performance of the CDRA and LiOH systems, and possible imbalance in CO2 levels between the ISS and STS while docked. This paper will cover efforts to troubleshoot the CO2 removal systems aboard the ISS and docked STS.

International Space Station (ISS) Advanced Recycle Filter Tank Assembly (ARFTA)

NASA Technical Reports Server (NTRS)

Nasrullah, Mohammed K.

2013-01-01

The International Space Station (ISS) Recycle Filter Tank Assembly (RFTA) provides the following three primary functions for the Urine Processor Assembly (UPA): volume for concentrating/filtering pretreated urine, filtration of product distillate, and filtration of the Pressure Control and Pump Assembly (PCPA) effluent. The RFTAs, under nominal operations, are to be replaced every 30 days. This poses a significant logistical resupply problem, as well as cost in upmass and new tanks purchase. In addition, it requires significant amount of crew time. To address and resolve these challenges, NASA required Boeing to develop a design which eliminated the logistics and upmass issues and minimize recurring costs. Boeing developed the Advanced Recycle Filter Tank Assembly (ARFTA) that allowed the tanks to be emptied on-orbit into disposable tanks that eliminated the need for bringing the fully loaded tanks to earth for refurbishment and relaunch, thereby eliminating several hundred pounds of upmass and its associated costs. The ARFTA will replace the RFTA by providing the same functionality, but with reduced resupply requirements

Crew Exploration Vehicle Environmental Control and Life Support Fire Protection Approach

NASA Technical Reports Server (NTRS)

Lewis, John F.; Barido, Richard; Tuan, George C.

2007-01-01

As part of preparing for the Crew Exploration Vehicle (CEV), the National Aeronautics and Space Administration (NASA) worked on developing the requirements to manage the fire risk. The new CEV poses unique challenges to current fire protection systems. The size and configuration of the vehicle resembles the Apollo capsule instead of the current Space Shuttle or the International Space Station. The smaller free air volume and fully cold plated avionic bays of the CEV requires a different approach in fire protection than the ones currently utilized. The fire protection approach discussed in this paper incorporates historical lessons learned and fire detection and suppression system design philosophy spanning from Apollo to the International Space Station. Working with NASA fire and materials experts, this approach outlines the best requirements for both the closed out area of the vehicle, such as the avionics bay, and the crew cabin area to address the unique challenges due to the size and configuration of the CEV.

Development of High Efficiency Clean Combustion Engine Designs for Spark-Ignition and Compression-Ignition Internal Combustion Engines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marriott, Craig; Gonzalez, Manual; Russell, Durrett

2011-06-30

This report summarizes activities related to the revised STATEMENT OF PROJECT OBJECTIVES (SOPO) dated June 2010 for the Development of High-Efficiency Clean Combustion engine Designs for Spark-Ignition and Compression-Ignition Internal Combustion Engines (COOPERATIVE AGREEMENT NUMBER DE-FC26-05NT42415) project. In both the spark- (SI) and compression-ignition (CI) development activities covered in this program, the goal was to develop potential production-viable internal combustion engine system technologies that both reduce fuel consumption and simultaneously met exhaust emission targets. To be production-viable, engine technologies were also evaluated to determine if they would meet customer expectations of refinement in terms of noise, vibration, performance, driveability, etc.more » in addition to having an attractive business case and value. Prior to this activity, only proprietary theoretical / laboratory knowledge existed on the combustion technologies explored The research reported here expands and develops this knowledge to determine series-production viability. Significant SI and CI engine development occurred during this program within General Motors, LLC over more than five years. In the SI program, several engines were designed and developed that used both a relatively simple multi-lift valve train system and a Fully Flexible Valve Actuation (FFVA) system to enable a Homogeneous Charge Compression Ignition (HCCI) combustion process. Many technical challenges, which were unknown at the start of this program, were identified and systematically resolved through analysis, test and development. This report documents the challenges and solutions for each SOPO deliverable. As a result of the project activities, the production viability of the developed clean combustion technologies has been determined. At this time, HCCI combustion for SI engines is not considered production-viable for several reasons. HCCI combustion is excessively sensitive to control variables such as internal dilution level and charge temperature. As a result, HCCI combustion has limited robustness when variables exceed the required narrow ranges determined in this program. HCCI combustion is also not available for the entire range of production engine speeds and loads, (i.e., the dynamic range is limited). Thus, regular SI combustion must be employed for a majority of the full dynamic range of the engine. This degrades the potential fuel economy impact of HCCI combustion. Currently-available combustion control actuators for the simple valve train system engine do not have the authority for continuous air - fuel or torque control for managing the combustion mode transitions between SI and HCCI and thus, require further refinement to meet customer refinement expectations. HCCI combustion control sensors require further development to enable robust long-term HCCI combustion control. Finally, the added technologies required to effectively manage HCCI combustion such as electric cam phasers, central direct fuel injection, cylinder pressure sensing, high-flow exhaust gas recirculation system, etc. add excessive on-engine cost and complexity that erodes the production-viability business« less

Symptom-Based Controller Therapy: A New Paradigm for Asthma Management

PubMed Central

Divekar, Rohit; Ameredes, Bill T.; Calhoun, William J.

2013-01-01

Appropriate management of persistent asthma, according to US and international guidelines, requires daily use of controller medications, most generally, inhaled corticosteroids (ICS). This approach, although effective and well established, imposes burdens of treatment and side effects onto asthma patients. A growing body of evidence suggests that patients with persistent asthma need not be managed with daily ICS, but rather can use them on an intermittent basis, occasioned by the occurrence of symptoms sufficient to warrant treatment with a rescue inhaler. Large, randomized, controlled studies, over a range of asthma severity, and in a range of ages from pediatrics to adults, suggest that in well-selected patients, a symptom based approach to administering controller therapy may produce equivalent outcomes, while reducing exposure to ICS. The concept of providing anti-inflammatory treatment to the patient, at the time inflammation is developing, is termed ‘temporal personalization’. The evidence to date suggests that symptom-based controller therapy is broadly useful in selected asthma patients, and is a management approach that could be incorporated into US and international guidelines for asthma. PMID:23904098

ORION Environmental Control and Life Support Systems Suit Loop and Pressure Control Analysis

NASA Technical Reports Server (NTRS)

Eckhardt, Brad; Conger, Bruce; Stambaugh, Imelda C.

2015-01-01

Under NASA's ORION Multi-Purpose Crew Vehicle (MPCV) Environmental Control and Life Support System (ECLSS) Project at Johnson Space Center's (JSC), the Crew and Thermal Systems Division has developed performance models of the air system using Thermal Desktop/FloCAD. The Thermal Desktop model includes an Air Revitalization System (ARS Loop), a Suit Loop, a Cabin Loop, and Pressure Control System (PCS) for supplying make-up gas (N2 and O2) to the Cabin and Suit Loop. The ARS and PCS are designed to maintain air quality at acceptable O2, CO2 and humidity levels as well as internal pressures in the vehicle Cabin and during suited operations. This effort required development of a suite of Thermal Desktop Orion ECLSS models to address the need for various simulation capabilities regarding ECLSS performance. An initial highly detailed model of the ARS Loop was developed in order to simulate rapid pressure transients (water hammer effects) within the ARS Loop caused by events such as cycling of the Pressurized Swing Adsorption (PSA) Beds and required high temporal resolution (small time steps) in the model during simulation. A second ECLSS model was developed to simulate events which occur over longer periods of time (over 30 minutes) where O2, CO2 and humidity levels, as well as internal pressures needed to be monitored in the cabin and for suited operations. Stand-alone models of the PCS and the Negative Pressure relief Valve (NPRV) were developed to study thermal effects within the PCS during emergency scenarios (Cabin Leak) and cabin pressurization during vehicle re-entry into Earth's atmosphere. Results from the Orion ECLSS models were used during Orion Delta-PDR (July, 2014) to address Key Design Requirements (KDR's) for Suit Loop operations for multiple mission scenarios.

A project of upgrading the operations control system of the Hungarian electric power system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oroszki, L.; Kovacs, G.

About 20 years ago an on-line EMS/SCADA system replaced the previously used off-line control system in the Hungarian power system. The system that has met the technological requirements of that time now became obsolete. A project started in 1995 by the Hungarian Power Companies, Ltd. (MVM Rt.), the regional utility companies and the power plant companies, with funding through a World Bank loan to cover international procurement, aims to upgrade that system into a complex, intelligent and state-of-the-art process control system. The new hierarchical system will rely on a distributed computer network structure, universally accepted hardware/software interface standards and communicationmore » protocols and use hardware platform independent software. The automatic generation control, performed from the National Dispatch Centre, will have expanded functionality, the most important single item of this will be the inclusion of automatic voltage/var control. The upgrading project includes the replacement of the substation and power plant remote terminal units and the installation of a telecommunication network to provide this telecontrol system with the necessary communications links. The supply contracts for both the master station and the remote terminal unit parts were awarded to the winners of open international bidding processes. In the project implementation MVM has the overall responsibility and works with assistance from international and Hungarian engineering firms.« less

Bioassay selection, experimental design and quality control/assurance for use in effluent assessment and control.

PubMed

Johnson, Ian; Hutchings, Matt; Benstead, Rachel; Thain, John; Whitehouse, Paul

2004-07-01

In the UK Direct Toxicity Assessment Programme, carried out in 1998-2000, a series of internationally recognised short-term toxicity test methods for algae, invertebrates and fishes, and rapid methods (ECLOX and Microtox) were used extensively. Abbreviated versions of conventional tests (algal growth inhibition tests, Daphnia magna immobilisation test and the oyster embryo-larval development test) were valuable for toxicity screening of effluent discharges and the identification of causes and sources of toxicity. Rapid methods based on chemiluminescence and bioluminescence were not generally useful in this programme, but may have a role where the rapid test has been shown to be an acceptable surrogate for a standardised test method. A range of quality assurance and control measures were identified. Requirements for quality control/assurance are most stringent when deriving data for characterising the toxic hazards of effluents and monitoring compliance against a toxicity reduction target. Lower quality control/assurance requirements can be applied to discharge screening and the identification of causes and sources of toxicity.

77 FR 12364 - Agency Information Collection; Activity Under OMB Review: Reporting Required for International...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... supplemental data for the International Civil Aviation Organization (ICAO). Comments are requested concerning.... 2138-0039. Title: Reporting Required for International Civil Aviation Organization (ICAO). Form No...-0002] Agency Information Collection; Activity Under OMB Review: Reporting Required for International...

76 FR 42613 - Reporting Requirements for U.S. Providers of International Telecommunications Services

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

...] Reporting Requirements for U.S. Providers of International Telecommunications Services AGENCY: Federal... Commission (Commission) is reviewing its reporting requirements for providers of international telecommunications services. The Commission proposes to amend its reporting requirements for providers of...

How Do Lessons Learned on the International Space Station (ISS) Help Plan Life Support for Mars?

NASA Technical Reports Server (NTRS)

Jones, Harry W.; Hodgson, Edward W.; Gentry, Gregory J.; Kliss, Mark H.

2016-01-01

How can our experience in developing and operating the International Space Station (ISS) guide the design, development, and operation of life support for the journey to Mars? The Mars deep space Environmental Control and Life Support System (ECLSS) must incorporate the knowledge and experience gained in developing ECLSS for low Earth orbit, but it must also meet the challenging new requirements of operation in deep space where there is no possibility of emergency resupply or quick crew return. The understanding gained by developing ISS flight hardware and successfully supporting a crew in orbit for many years is uniquely instructive. Different requirements for Mars life support suggest that different decisions may be made in design, testing, and operations planning, but the lessons learned developing the ECLSS for ISS provide valuable guidance.

Consumer-operated service organizations: organizational characteristics, community relationships, and the potential for citizenship.

PubMed

Tanenbaum, Sandra J

2012-08-01

Consumer-operated service organizations (COSOs) are independent organizations whose administrative and financial control resides with consumers. Based on a 2008 mail survey and followup interviews conducted in 2009, this study depicts the internal characteristics and external relationships, as well as some relationships between the two, of COSOs in one state. Profiles include on the one hand, governance structures, services provided, sources and levels of funding, etc. and on the other, relationships between COSOs and other actors in the mental health system and the local community. COSOs emerge as more self-governing and community-based than required by certification requirements and as developing internally and externally in tandem. COSOs are not only adjunct or alternative service providers, but also civic associations and loci for the expression of citizenship by mentally ill people.

Validation of a "Kane's Dynamics" Model for the Active Rack Isolation System

NASA Technical Reports Server (NTRS)

Beech, Geoffrey S.; Hampton, R. David

2000-01-01

Many microgravity space-science experiments require vibratory acceleration levels unachievable without active isolation. The Boeing Corporation's Active Rack Isolation System (ARIS) employs a novel combination of magnetic actuation and mechanical linkages, to address these isolation requirements on the International Space Station (ISS). ARIS provides isolation at the rack (international Standard Payload Rack, or ISPR) level. Effective model-based vibration isolation requires (1) an isolation device, (2) an adequate dynamic (i.e., mathematical) model of that isolator, and (3) a suitable, corresponding controller, ARIS provides the ISS response to the first requirement. In November 1999, the authors presented a response to the second ("A 'Kane's Dynamics' model for the Active Rack Isolation System", Hampton and Beech) intended to facilitate an optimal-controls approach to the third. This paper documents the validation of that high-fidelity dynamic model of ARIS. As before, this model contains the full actuator dynamics, however, the umbilical models are not included in this presentation. The validation of this dynamics model was achieved by utilizing two Commercial Off the Shelf (COTS) software tools: Deneb's ENVISION, and Online Dynamics' AUTOLEV. ENVISION is a robotics software package developed for the automotive industry that employs 3-dimensional (3-D) Computer Aided Design (CAD) models to facilitate both forward and inverse kinematics analyses. AUTOLEV is a DOS based interpreter that is designed in general to solve vector based mathematical problems and specifically to solve Dynamics problems using Kane's method.

AMO EXPRESS: A Command and Control Experiment for Crew Autonomy Onboard the International Space Station

NASA Technical Reports Server (NTRS)

Cornelius, Randy; Frank, Jeremy; Garner, Larry; Haddock, Angie; Stetson, Howard; Wang, Lui

2015-01-01

The Autonomous Mission Operations project is investigating crew autonomy capabilities and tools for deep space missions. Team members at Ames Research Center, Johnson Space Center and Marshall Space Flight Center are using their experience with ISS Payload operations and TIMELINER to: move earth based command and control assets to on-board for crew access; safely merge core and payload command procedures; give the crew single action intelligent operations; and investigate crew interface requirements.

Advanced Environmental Monitoring and Control Program: Strategic Plan

NASA Technical Reports Server (NTRS)

Schmidt, Gregory

1996-01-01

Human missions in space, from short-duration shuttle missions lasting no more than several days to the medium-to-long-duration missions planned for the International Space Station, face a number of hazards that must be understood and mitigated for the mission to be carried out safely. Among these hazards are those posed by the internal environment of the spacecraft itself; through outgassing of toxic vapors from plastics and other items, failures or off-nominal operations of spacecraft environmental control systems, accidental exposure to hazardous compounds used in experiments: all present potential hazards that while small, may accumulate and pose a danger to crew health. The first step toward mitigating the dangers of these hazards is understanding the internal environment of the spacecraft and the compounds contained within it. Future spacecraft will have integrated networks of redundant sensors which will not only inform the crew of hazards, but will pinpoint the problem location and, through analysis by intelligent systems, recommend and even implement a course of action to stop the problem. This strategic plan details strategies to determine NASA's requirements for environmental monitoring and control systems for future spacecraft, and goals and objectives for a program to answer these needs.

Incidental brain MRI findings in an autism twin study.

PubMed

Monterrey, Julio C; Philips, Jennifer; Cleveland, Sue; Tanaka, Serena; Barnes, Patrick; Hallmayer, Joachim F; Reiss, Alan L; Lazzeroni, Laura C; Hardan, Antonio Y

2017-01-01

Brain magnetic resonance imaging (MRI) studies suggest the prevalence of asymptomatic "incidental" findings (IF) in autism spectrum disorder (ASD) is similar to that of neurotypically developing (NT) controls. However, given the causes of IF may include both genetic and environmental factors, a twin study would facilitate comparing brain IF between ASD and NT subjects. MRI scans were examined to assess the prevalence of brain IF in twin "case pairs" (at least one twin with diagnosis of ASD) and twin "control pairs" (NT). Fifty case pairs and thirty-two control pairs were analyzed. IF were found in 68% of subjects with ASD, 71% of unaffected ASD siblings, and in 58% of control subjects (P = 0.4). IF requiring clinical follow-up occurred more frequently in subjects with ASD compared to NT controls (17% vs. 5%, respectively; P = 0.02). The concordance rate of IF in twins was 83%. A mixed effects model found younger age, male sex, and "family environment" to be significantly associated with IF. There was no difference in the prevalence rate of IF between ASD subjects and NT controls. More IF required clinical follow-up in ASD subjects compared to NT controls. The prevalence rate of IF observed in this twin study was higher than rates previously reported in singleton studies. Our results suggest the shared environment of twins - perhaps in utero - increases the risk of brain IF. Brain MRI in the initial work-up of ASD may be indicated in twins, especially in males. Autism Res 2017, 10: 113-120. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

An experimental toolbox for the generation of cold and ultracold polar molecules

NASA Astrophysics Data System (ADS)

Zeppenfeld, Martin; Gantner, Thomas; Glöckner, Rosa; Ibrügger, Martin; Koller, Manuel; Prehn, Alexander; Wu, Xing; Chervenkov, Sotir; Rempe, Gerhard

2017-01-01

Cold and ultracold molecules enable fascinating applications in quantum science. We present our toolbox of techniques to generate the required molecule ensembles, including buffergas cooling, centrifuge deceleration and optoelectrical Sisyphus cooling. We obtain excellent control over both the motional and internal molecular degrees of freedom, allowing us to aim at various applications.

78 FR 31444 - Amendment to the International Traffic in Arms Regulations: Revision of U.S. Munitions List...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

...) 150 meters from geosynchronous orbit (GEO); or (iv) 225 meters from high earth orbit (HEO); (11) Space... operating frequencies above 10 GHz; (15) ``Space-qualified'' oscillator for radar in paragraph (a) of this... Fiscal Year 1999, required that space-related items, including all satellites, were to be controlled as...

Database Migration for Command and Control

DTIC Science & Technology

2002-11-01

Sql - proprietary JDP Private Area Air defense data Defended asset list Oracle 7.3.2 - Automated process (OLTP...TADIL warnings Oracle 7.3.2 Flat File - Discrete transaction with data upds - NRT response required Pull mission data Std SQL ...level execution data Oracle 7.3 User update External interfaces Auto/manual backup Messaging Proprietary replication (internally) SQL Web server

78 FR 19630 - Interpretation of the Rest Requirements of Nonstop International Supplemental Operations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-02

...'' at 0900 (8 hours of flight time). Assuming that the four pilots evenly divide time at the controls... interpretation because it has come to our attention that supplemental air carriers might be misinterpreting and... hypothetical example of a supplemental air carrier that has scheduled four pilots to conduct a non- [[Page...

Laboratory Test of Reciprocating Internal Combustion Engines

DTIC Science & Technology

2016-02-04

testing require extremely accurate fuel consumption measurement, and the ability to temperature condition the fuel. Most dynamometer manufacturers...include, but are not limited to, differences in fuels, lubrication, temperatures , engine control module parameters, component wear, exhaust, and air...exhaust gas recirculation (EGR) fuel consumption 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR 18. NUMBER OF PAGES 38

The Role of a Mental Model in Learning to Operate a Device.

ERIC Educational Resources Information Center

Kieras, David E.; Bovair, Susan

1984-01-01

Describes three studies concerned with learning to operate a control panel device and how this learning is affected by understanding a device model that describes its internal mechanism. Results indicate benefits of a device model depend on whether it supports direct inference of exact steps required to operate the device. (Author/MBR)

A Pictorial History of the Code 717 Unmanned Systems Group: Air, Land, and Sea. Volume 1: 1970-1999

DTIC Science & Technology

2016-04-28

requirements. 54 a) b) Figure 67. a) Site preparation for Building 585 began with demolition of the foundation for the oil -well derrick...Proceedings of the 9th International Conference on Informatics in Control, Automation and Robotics (ICINCO). 28–31 July, Rome, Italy. Pransky, J. 1997

The Troll HSE Risk Management System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiig, E.; Berthelsen, I.; Donovan, K.

1996-12-31

The Petroleum Act and Internal Control regulations in Norway lay down requirements for how HSE shall be Managed and documented. To comply with the Norwegian legislation the Troll Project has developed an HSE Risk Management System (RMS) structured around Hazards and Effects Management. The resulting quality, technical and operating integrity, and HSE performance are an endorsement of the power of RMS.

Wear of matrix overdenture attachments after one to eight years of clinical use.

PubMed

Fromentin, Olivier; Lassauzay, Claire; Nader, Samer Abi; Feine, Jocelyne; de Albuquerque, Rubens F

2012-03-01

Matrices of unsplinted attachment systems are generally reported to be the weak component of implant overdentures, often requiring frequent maintenance. Clinical wear results in reduced retention of the prosthesis, requiring activation or renewal of the matrix to restore the initial level of retention. The purpose of this retrospective study was to measure the wear of the matrix of a ball attachment after various periods of clinical wear. Seventy specimens of 3 groups of matrices of ball attachments that had been in use for mean periods of 12.3 months (1Y group, n=26), 39.0 months (3Y group, n=28) and 95.6 months (8Y group, n=16) were retrieved from 35 patients (2 specimens per patient) and measured on a coordinate measuring machine equipped with a touch trigger probe. Ten unused matrices were used as controls (CTRL group). The external and internal matrix diameters and deviations from circularity were measured. For the various time periods, the decreases in matrix thickness were calculated and compared with controls. Kruskal-Wallis 1-way ANOVA by ranks, followed by the Mann-Whitney post hoc tests, were conducted to test for differences in median values among groups (α =.05). For the internal upper diameter of the matrices tested, the Kruskal-Wallis and Mann-Whitney tests revealed significant differences for the 3 groups compared to the controls. For group 1Y, a significant difference (P<.001) of the internal upper diameter was found compared to the CTRL group. Compared to the controls, the nonparametric analyses for groups 3Y and 8Y showed significant differences for the internal upper diameter (P<.001) and deviations from circularity (P<.001). For groups 1Y, 3Y and 8Y, matrix thickness losses were 07, 47 and 70 μm, respectively. Within the limitations of this study, it was observed that one year of clinical wear had limited effect on the ball attachment matrices. Three to 8 years of clinical use resulted in a significant decrease of matrix thickness, especially at the tip of the retentive lamellae. Copyright © 2012 The Editorial Council of the Journal of Prosthetic Dentistry. Published by Mosby, Inc. All rights reserved.

Leveraging existing information for use in a National Nuclear Forensics Library (NNFL)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davydov, Jerry; Dion, Heather; LaMont, Stephen

A National Nuclear Forensics Library (NNFL) assists a State to assess whether nuclear material encountered out of regulatory control is of domestic or international origin. And by leveraging nuclear material registries, nuclear enterprise records, and safeguards accountancy information, as well as existing domestic technical capability and subject-matter domain expertise, states can better assess the effort required for setting up an NNFL. For states who are largely recipients of nuclear and radiological materials and have no internal production capabilities may create an NNFL that relies on existing information rather than carry out advanced analyses on domestic materials.

Leveraging existing information for use in a National Nuclear Forensics Library (NNFL)

DOE PAGES

Davydov, Jerry; Dion, Heather; LaMont, Stephen; ...

2015-12-16

A National Nuclear Forensics Library (NNFL) assists a State to assess whether nuclear material encountered out of regulatory control is of domestic or international origin. And by leveraging nuclear material registries, nuclear enterprise records, and safeguards accountancy information, as well as existing domestic technical capability and subject-matter domain expertise, states can better assess the effort required for setting up an NNFL. For states who are largely recipients of nuclear and radiological materials and have no internal production capabilities may create an NNFL that relies on existing information rather than carry out advanced analyses on domestic materials.

Glenn's Telescience Support Center Provided Around-the-Clock Operations Support for Space Experiments on the International Space Station

NASA Technical Reports Server (NTRS)

Malarik, Diane C.

2005-01-01

NASA Glenn Research Center s Telescience Support Center (TSC) allows researchers on Earth to operate experiments onboard the International Space Station (ISS) and the space shuttles. NASA s continuing investment in the required software, systems, and networks provides distributed ISS ground operations that enable payload developers and scientists to monitor and control their experiments from the Glenn TSC. The quality of scientific and engineering data is enhanced while the long-term operational costs of experiments are reduced because principal investigators and engineering teams can operate their payloads from their home institutions.

Spaceport Command and Control System Automated Testing

NASA Technical Reports Server (NTRS)

Stein, Meriel

2017-01-01

The Spaceport Command and Control System (SCCS) is the National Aeronautics and Space Administrations (NASA) launch control system for the Orion capsule and Space Launch System, the next generation manned rocket currently in development. This large system requires high quality testing that will properly measure the capabilities of the system. Automating the test procedures would save the project time and money. Therefore, the Electrical Engineering Division at Kennedy Space Center (KSC) has recruited interns for the past two years to work alongside full-time engineers to develop these automated tests, as well as innovate upon the current automation process.

Spaceport Command and Control System Automation Testing

NASA Technical Reports Server (NTRS)

Hwang, Andrew

2017-01-01

The Spaceport Command and Control System (SCCS) is the National Aeronautics and Space Administrations (NASA) launch control system for the Orion capsule and Space Launch System, the next generation manned rocket currently in development. This large system requires high quality testing that will properly measure the capabilities of the system. Automating the test procedures would save the project time and money. Therefore, the Electrical Engineering Division at Kennedy Space Center (KSC) has recruited interns for the past two years to work alongside full-time engineers to develop these automated tests, as well as innovate upon the current automation process.

Reducing Bolt Preload Variation with Angle-of-Twist Bolt Loading

NASA Technical Reports Server (NTRS)

Thompson, Bryce; Nayate, Pramod; Smith, Doug; McCool, Alex (Technical Monitor)

2001-01-01

Critical high-pressure sealing joints on the Space Shuttle reusable solid rocket motor require precise control of bolt preload to ensure proper joint function. As the reusable solid rocket motor experiences rapid internal pressurization, correct bolt preloads maintain the sealing capability and structural integrity of the hardware. The angle-of-twist process provides the right combination of preload accuracy, reliability, process control, and assembly-friendly design. It improves significantly over previous methods. The sophisticated angle-of-twist process controls have yielded answers to all discrepancies encountered while the simplicity of the root process has assured joint preload reliability.

Material control and accountancy at EDF PWR plants; GCN: Gestion du Combustible Nucleaire

DOE Office of Scientific and Technical Information (OSTI.GOV)

de Cormis, F.

1991-01-01

The paper describes the comprehensive system which is developed and implemented at Electricite de France to provide a single reliable nuclear material control and accounting system for all nuclear plants. This software aims at several objectives among which are: the control and the accountancy of nuclear material at the plant, the optimization of the consistency of data by minimizing the possibility of transcription errors, the fulfillment of the statutory requirements by automatic transfer of reports to national and international safeguards authorities, the servicing of other EDF users of nuclear material data for technical or commercial purposes.

Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKϵ-IRF3 axis activation.

PubMed

Tsukamoto, Hiroki; Takeuchi, Shino; Kubota, Kanae; Kobayashi, Yohei; Kozakai, Sao; Ukai, Ippo; Shichiku, Ayumi; Okubo, Misaki; Numasaki, Muneo; Kanemitsu, Yoshitomi; Matsumoto, Yotaro; Nochi, Tomonori; Watanabe, Kouichi; Aso, Hisashi; Tomioka, Yoshihisa

2018-05-14

Toll-like receptor 4 (TLR4) is an indispensable immune receptor for lipopolysaccharide (LPS), a major component of the Gram-negative bacterial cell wall. Following LPS stimulation, TLR4 transmits the signal from the cell surface and becomes internalized in an endosome. However, the spatial regulation of TLR4 signaling is not fully understood. Here, we investigated the mechanisms of LPS-induced TLR4 internalization and clarified the roles of the extracellular LPS-binding molecules, LPS-binding protein (LBP), and glycerophosphatidylinositol-anchored protein (CD14). LPS stimulation of CD14-expressing cells induced TLR4 internalization in the presence of serum, and an inhibitory anti-LBP mAb blocked its internalization. Addition of LBP to serum-free cultures restored LPS-induced TLR4 internalization to comparable levels of serum. The secretory form of the CD14 (sCD14) induced internalization but required a much higher concentration than LBP. An inhibitory anti-sCD14 mAb was ineffective for serum-mediated internalization. LBP lacking the domain for LPS transfer to CD14 and a CD14 mutant with reduced LPS binding both attenuated TLR4 internalization. Accordingly, LBP is an essential serum molecule for TLR4 internalization, and its LPS transfer to membrane-anchored CD14 (mCD14) is a prerequisite. LBP induced the LPS-stimulated phosphorylation of TBK1, IKKϵ, and IRF3, leading to IFN-β expression. However, LPS-stimulated late activation of NFκB or necroptosis were not affected. Collectively, our results indicate that LBP controls LPS-induced TLR4 internalization, which induces TLR adaptor molecule 1 (TRIF)-dependent activation of the TBK1-IKKϵ-IRF3-IFN-β pathway. In summary, we showed that LBP-mediated LPS transfer to mCD14 is required for serum-dependent TLR4 internalization and activation of the TRIF pathway. Copyright © 2018, The American Society for Biochemistry and Molecular Biology.

Assessment and Accommodation of Thermal Expansion of the Internal Active Thermal Control System Coolant During Launch to On-Orbit Activation of International Space Station Elements

NASA Technical Reports Server (NTRS)

Edwards, Darryl; Ungar, Eugene K.; Holt, James M.

2002-01-01

The International Space Station (ISS) employs an Internal Active Thermal Control System (IATCS) comprised of several single-phase water coolant loops. These coolant loops are distributed throughout the ISS pressurized elements. The primary element coolant loops (i.e. U.S. Laboratory module) contain a fluid accumulator to accomodate thermal expansion of the system. Other element coolant loops are parasitic (i.e. Airlock), have no accumulator, and require an alternative approach to insure that the system maximum design pressure (MDP) is not exceeded during the Launch to Activation (LTA) phase. During this time the element loops is a stand alone closed system. The solution approach for accomodating thermal expansion was affected by interactions of system components and their particular limitations. The mathematical solution approach was challenged by the presence of certain unknown or not readily obtainable physical and thermodynamic characteristics of some system components and processes. The purpose of this paper is to provide a brief description of a few of the solutions that evolved over time, a novel mathematical solution to eliminate some of the unknowns or derive the unknowns experimentally, and the testing and methods undertaken.

Assessment and Accommodation of Thermal Expansion of the Internal Active Thermal Control System Coolant During Launch to On-Orbit Activation of International Space Station Elements

NASA Technical Reports Server (NTRS)

Edwards, J. Darryl; Ungar, Eugene K.; Holt, James M.; Turner, Larry D. (Technical Monitor)

2001-01-01

The International Space Station (ISS) employs an Internal Active Thermal Control System (IATCS) comprised of several single-phase water coolant loops. These coolant loops are distributed throughout the ISS pressurized elements. The primary element coolant loops (i.e., US Laboratory module) contain a fluid accumulator to accommodate thermal expansion of the system. Other element coolant loops are parasitic (i.e., Airlock), have no accumulator, and require an alternative approach to insure that the system Maximum Design Pressure (MDP) is not exceeded during the Launch to Activation phase. During this time the element loop is a stand alone closed individual system. The solution approach for accommodating thermal expansion was affected by interactions of system components and their particular limitations. The mathematical solution approach was challenged by the presence of certain unknown or not readily obtainable physical and thermodynamic characteristics of some system components and processes. The purpose of this paper is to provide a brief description of a few of the solutions that evolved over time, a novel mathematical solution to eliminate some of the unknowns or derive the unknowns experimentally, and the testing and methods undertaken.

Stability analysis of multiple-robot control systems

NASA Technical Reports Server (NTRS)

Wen, John T.; Kreutz, Kenneth

1989-01-01

In a space telerobotic service scenario, cooperative motion and force control of multiple robot arms are of fundamental importance. Three paradigms to study this problem are proposed. They are distinguished by the set of variables used for control design. They are joint torques, arm tip force vectors, and an accelerated generalized coordinate set. Control issues related to each case are discussed. The latter two choices require complete model information, which presents practical modeling, computational, and robustness problems. Therefore, focus is on the joint torque control case to develop relatively model independent motion and internal force control laws. The rigid body assumption allows the motion and force control problems to be independently addressed. By using an energy motivated Lyapunov function, a simple proportional derivative plus gravity compensation type of motion control law is always shown to be stabilizing. The asymptotic convergence of the tracing error to zero requires the use of a generalized coordinate with the contact constraints taken into account. If a non-generalized coordinate is used, only convergence to a steady state manifold can be concluded. For the force control, both feedforward and feedback schemes are analyzed. The feedback control, if proper care has been taken, exhibits better robustness and transient performance.

Space Station needs, attributes and architectural options. Volume 2, book 2, part 1: Mission implementation concepts

NASA Technical Reports Server (NTRS)

1983-01-01

The overall configuration and modules of the initial and evolved space station are described as well as tended industrial and polar platforms. The mass properties that are the basis for costing are summarized. User friendly attributes (interfaces, resources, and facilities) are identified for commercial; science and applications; industrial park; international participation; national security; and the external tank option. Configuration alternates studied to determine a baseline are examined. Commonality for clustered 3-man and 9-man stations are considered as well as the use of tethered platforms. Requirements are indicated for electrical, communication and tracking; data management Subsystem requirements for electrical, data management, communication and tracking, environment control/life support system; and guidance navigation and control subsystems are identified.

Space Station needs, attributes and architectural options. Volume 2, book 2, part 1: Mission implementation concepts

NASA Astrophysics Data System (ADS)

1983-04-01

The overall configuration and modules of the initial and evolved space station are described as well as tended industrial and polar platforms. The mass properties that are the basis for costing are summarized. User friendly attributes (interfaces, resources, and facilities) are identified for commercial; science and applications; industrial park; international participation; national security; and the external tank option. Configuration alternates studied to determine a baseline are examined. Commonality for clustered 3-man and 9-man stations are considered as well as the use of tethered platforms. Requirements are indicated for electrical, communication and tracking; data management Subsystem requirements for electrical, data management, communication and tracking, environment control/life support system; and guidance navigation and control subsystems are identified.

Phytometric intelligence sensors

NASA Technical Reports Server (NTRS)

Seelig, Hans-Dieter (Inventor); Stoner, II, Richard J. (Inventor); Hoehn, Alexander (Inventor); Adams, III, William Walter (Inventor)

2010-01-01

Methods and apparatus for determining when plants require watering, and methods of attending to the watering of plants including signaling the grower that the plants are in need of hydration are provided. The novel methods include real-time measurement of plant metabolics and phytometric physiology changes of intrinsic physical or behavioral traits within the plant such as determining physiological flux measurement of enzyme flux due to environmental changes such as the wind and drought stress, soil and plant mineral deficiencies, or the interaction with a bio-control for organic disease control including, cell movement, signal transduction, internal chemical processes and external environmental processes including when plants require watering, and methods of attending to the watering of plants including signaling the grower that the plants are in need of hydration.

Definition of criteria and indicators for the prevention of Healthcare-Associated Infections (HAIs) in hospitals for the purposes of Italian institutional accreditation and performance monitoring.

PubMed

Tardivo, S; Moretti, F; Nobile, M; Agodi, A; Appignanesi, R; Arrigoni, C; Baldovin, T; Brusaferro, S; Canino, R; Carli, A; Chiesa, R; D'Alessandro, D; D'Errico, M M; Giuliani, G; Montagna, M T; Moro, M; Mura, I I; Novati, R; Orsi, G B; Pasquarella, C; Privitera, G; Ripabelli, G; Rossini, A; Saia, M; Sodano, L; Torregrossa, M V; Torri, E; Zarrilli, R; Auxilia, F; SItI, Gisio

2017-01-01

Healthcare-associated infections (HAIs) are an important issue in terms of quality of care. HAIs impact patient safety by contributing to higher rates of preventable mortality and prolonged hospitalizations. In Italy, analysis of the currently available accreditation systems shows a substantial heterogeneity of approaches for the prevention and surveillance of HAIs in hospitals. The aim of the present study is to develop and propose the use of a synthetic assessment tool that could be implemented homogenously throughout the nation. An analysis of nine international and of the 21 Italian regional accreditation systems was conducted in order to identify requirements and indicators implemented for HAI prevention and control. Two relevant reviews on this topic were further analyzed to identify additional evidence-based criteria. The project team evaluated all the requirements and indicators with consensus meeting methodology, then those applicable to the Italian context were grouped into a set of "focus areas". The analysis of international systems and Italian regional accreditation manuals led to the identification respectively of 19 and 14 main requirements, with relevant heterogeneity in their application. Additional evidence-based criteria were included from the reviews analysis. From the consensus among the project team members all the standards were compared and 20 different thematic areas were identified, with a total of 96 requirements and indicators for preventing and monitoring HAIs. The study reveals a great heterogeneity in the definition of accreditation criteria between the Italian regions. The introduction of a uniform, synthetic assessment instrument, based on the review of national and international standards, may serve as a self-assessment tool to evaluate the achievement of a minimum standards set for HAIs prevention and control in healthcare facilities. This may be used as an assessment tool by the Italian institutional accreditation system, also useful to reduce regional disparities.